TY - JOUR AU - Beutler, J.A. AU - Shoemaker, R.H. AU - Johnson, T. AU - Boyd, M.R. TI - Cytotoxic geranyl stilbenes from Macaranga schweinfurthii [Language: en] JO - Journal of Natural Products PY - 1998/12/01/ VL - 61 IS - 12 SP - 1509 SN - 01633864 AV - Location: *US (DNAL 442.8 L77); Number: 1999005614 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE; AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; AGRIS; COMPOSITE RECORD. Database Contributor ID: 9868152; ALNAP-013764; US1999005614. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 9868152. Author Affiliation: Beutler, J.A. : National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 1; Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA 2; AB - ALNAP Abstract: Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity KW - Maryland KW - Maryland KW - cancer KW - cytotoxic KW - cytotoxicity KW - development KW - drug KW - drug discovery KW - Euphorbiaceae KW - geranyl KW - geranyl stilbene KW - Isolated KW - laboratory KW - Macaranga schweinfurthii KW - mass spectral KW - mechanism KW - Methods KW - Natural Product KW - natural products KW - NCI KW - NMR KW - Novel KW - plant KW - products KW - research KW - spectral methods KW - stilbene KW - stilbenes KW - structure KW - structures KW - therapeutic KW - therapeutics KW - Three KW - cameroon KW - drug plants KW - leaves KW - chemical composition KW - aromatic compounds KW - spectrometry KW - chemical structure KW - toxic substances KW - antineoplastic agents KW - mankind KW - cell culture KW - cameroun KW - plante medicinale KW - feuille KW - composition chimique KW - compose aromatique KW - spectrometrie KW - structure chimique KW - substance toxique KW - medicament cytostatique KW - genre humain KW - culture de cellule KW - camerun KW - plantas medicinales KW - hojas KW - composicion quimica KW - compuestos aromaticos KW - espectrometria KW - estructura quimica KW - sustancias toxicas KW - agentes antineoplasticos KW - genero humano KW - cultivo de celulas KW - schweinfurthins KW - stelletins KW - cephalostatins KW - cns tumor-derived lines sf-295 and sf-539 KW - spectral analysis KW - cytotoxic compounds KW - cell lines UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9868152&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Naficy, A.B. AU - Abu-Elyazeed, R. AU - Holmes, J.L. AU - Rao, M.R. AU - Savarino, S.J. AU - Kim, Y. AU - Wierzba, T.F. AU - Peruski, L. AU - Lee, Y.J. AU - Gentsch, J.R. AU - Glass, R.I. AU - Clemens, J.D. TI - Epidemiology of rotavirus diarrhea in Egyptian children and implications for disease control JO - American Journal of Epidemiology PY - 1999/01/01/ VL - 150 IS - 7 SP - 770 SN - 00029262 N1 - Note: HEALTHLIT Location: University of Pretoria; Contract Number: Y1-HD-0026-01/HD/NICHD NIH HHS. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 0225249X; 10512431. Database Subset: AFRICAN HEALTHLINE. Corporate Author: National Institute of Child Health and Human Development. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 0225249X. Author Affiliation: Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20852, USA 1; AB - MEDLINE Abstract: Reliable epidemiologic data are essential for formulating effective policy to control rotavirus disease through immunization. The objective of this study was to describe the epidemiology of rotavirus diarrhea in a population-based cohort of children under 3 years of age residing in Abu Homos, Egypt, in 1995-1996. Rotavirus diarrhea incidence rates (episodes per person-year) were 0.13 for infants aged <6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months, and 0.15 for those aged 24-35 months. Fifty-six percent of children with rotavirus diarrhea had clinical dehydration; 90% of rotavirus diarrheal episodes occurred between July and November. In infants under 1 year of age, receipt of breast milk was associated with a lower incidence of rotavirus diarrhea. No other sociodemographic or environmental factor was found to be significantly associated with rotavirus diarrhea. Of 46 rotavirus isolates with strains identified, 41 (89%) were G serotypes 1 and 2. Rotavirus diarrhea was a major cause of morbidity in this cohort. Promotion of breastfeeding may exert a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures. The use of effective immunization against rotavirus in early infancy should be considered a public health priority.; This study describes the epidemiology of rotavirus diarrhea in a population-based cohort of children under 3 years of age residing in Abu Homos, Egypt, during 1995-96. Samples consisted of a cohort of children under the age of 24 months assembled from two villages in the vicinity of Abu Homos. The age-specific incidence rates of rotavirus diarrheal episodes per person-year were 0.13 for infants aged 6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months, and 0.15 for those aged 24-35 months. No rotavirus diarrheal incidence occurred in infants under 20 weeks of age. The monthly incidence rates of rotavirus diarrhea demonstrate that 90% of the disease episodes occurred during the warmer months of July-November, with a peak incidence in August. In infants under 1 year of age, breast-feeding was associated with a lower incidence of rotavirus diarrhea. Promotion of breast-feeding may employ a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures KW - Public health and Epidemiology (G600) KW - Public health and Epidemiology (G600) KW - North Africa KW - Egypt KW - Breast feeding KW - Waterborne diseases KW - Diarrhoea KW - Pathogenic viruses KW - Rotaviruses KW - Epidemiology KW - Children KW - Developing countries KW - Seasonal variations KW - Disease control KW - Future possibilities KW - Vaccines UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=0225249X&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - BONKOVSKY, Frederick O TI - Ethical issues in perinatal HIV JO - Clinics in Perinatology PY - 1994/01/01/ VL - 21 IS - 1 SP - 15 EP - 28 SN - 00955108 N1 - Note: AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; CHILDREN; HEALTHLINK Location: CA/HC4.424. Database Contributor: HEALTHLINK WORLDWIDE; MEDLINE; AIDS CONSORTIUM RESOURCE CENTRE DATABASE; COMPOSITE RECORD. Database Contributor ID: HEALTHLINK-017852; 8013183; Legal-199500188. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: HEALTHLINK-017852. Author Affiliation: National Institutes of Health, Bethesda, Maryland 1; AB - MEDLINE Abstract: Perinatal HIV raises difficult ethical issues and value conflicts for practitioners, patients, and the public. Part I gives an overview of US infant HIV realities and the devastating worldwide HIV and tuberculosis pandemics. In part II, the major ethical issues regarding perinatal HIV including confidentiality, advance directives, US rights, and right to medical care where HIV exists. Also reviewed are quality of life and death, consideration of selective and more general problems associated with prenatal and neonatal screening, and pregnancy termination and postponement where perinatal HIV is likely KW - CHILDREN KW - diseases and disease control KW - hiv [aids] KW - CHILDREN KW - diseases and disease control KW - hiv [aids] KW - INFANTS KW - CHILDREN KW - ETHICS, MEDICAL KW - QUALITY OF LIFE KW - ABORTION KW - PAEDIATRIC AIDS KW - STATISTICS KW - TRANSMISSION, MOTHER TO CHILD KW - abortion KW - children KW - counselling KW - ethical issues KW - HIV infection KW - resource allocation KW - transmission - maternal KW - women UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=HEALTHLINK-017852&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Quinn, T C TI - Global burden of the HIV pandemic JO - Lancet PY - 1996/01/01/ VL - 348 IS - 9025 | 9020 SP - 99 EP - 106 N1 - Note: AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; HIV EPIDEMIC. Database Contributor: AIDS CONSORTIUM RESOURCE CENTRE DATABASE; MEDLINE; COMPOSITE RECORD. Database Contributor ID: Legal-199700570; 8676726. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: Legal-199700570. Author Affiliation: National Institute of Allergy and Infectious Diseases, Baltimore, Maryland, USA 1; AB - MEDLINE Abstract: Within the global pandemic of HIV infection there are many different epidemics, each with its own dynamics and each influenced by many factors including time of introduction of the virus, population density, and cultural and social issues. Effective management strategies depend on knowledge of all these factors. By the year 2000, WHO projections are that 26 million persons will be infected with HIV, more than 90% of whom will be in developing countries. To control AIDS, countries must not only promote changes in individual behaviour but also address social issues such as unemployment, rapid urbanisation, migration, and the status of women.; The world is currently experiencing a global pandemic of HIV infection. There are, however, many different epidemics within the global pandemic of HIV, each with its own dynamics and each influenced by many factors, including the time of introduction of the virus, population density, and cultural and social issues. Effective management strategies depend upon knowledge of all these factors. By the year 2000, the World Health Organization projects that 26 million people will be infected with HIV, more than 90% of whom will be in developing countries. The author stresses that to control AIDS, countries must not only promote changes in individual behavior, but also address social issues such as unemployment, rapid urbanization, migration, and women's status. This paper describes the epidemiological features of the HIV pandemic, including its evolution, economic and demographic impacts, unique characteristics in different regions of the world, and projections for the next four years KW - HIV EPIDEMIC KW - International KW - HIV EPIDEMIC KW - International KW - HIV EPIDEMIC KW - PLANNING KW - DEVELOPING COUNTRIES KW - SEXUAL BEHAVIOUR CHANGE KW - SOCIOECONOMIC ASPECTS UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=Legal-199700570&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Grady, C TI - Grappling with global concerns in the search for an HIV vaccine JO - Association of Nurses in AIDS Care. Journal PY - 1999/01/01/ VL - 10 IS - 1 SP - 17 EP - 20 PB - Elsevier Inc.: 625 Walnut St, Curtis Ctr, Philadelphia, PA 19106 United States SN - 10553290 N1 - Database Contributor: AFRICAN DEVELOPMENT DATABASE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: AFD-1060720; 1060720. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: AFD-1060720. Author Affiliation: [1999-2007] - Human Subjects Research, Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892-1156, USA 1; AB - AFRICAN DEVELOPMENT Abstract: There is a need for increasing international collaboration in the search for a safe and effective HIV vaccine. In addition to the ethical issues that must be considered in conducting any clinical research, unique issues arise in vaccine research and in international research. Careful deliberation and guideline development regarding the ethics of international vaccine research was the focus of a series of recent consultations sponsored by Joint United Nations Programme on HIV/AIDS (UNAIDS) around the world KW - Microbiology / Biotechnology KW - Bacteria / Fungi / Viruses KW - Diseases / Pathogens KW - Experimental research KW - Health / Public health KW - Medical Science KW - Biochemistry / Molecular biology KW - World KW - Microbiology / Biotechnology KW - Bacteria / Fungi / Viruses KW - Diseases / Pathogens KW - Experimental research KW - Health / Public health KW - Medical Science KW - Biochemistry / Molecular biology KW - World KW - hiv [human immunodeficiency virus] KW - hiv vaccine KW - hiv vaccine development KW - biochemical research KW - antiviral activities KW - vaccine research KW - hiv prevention KW - hiv transmission UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=AFD-1060720&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Fuller, R.W. AU - Blunt, J.W. AU - Boswell, J.L. AU - Cardellina, J.H. II. AU - Boyd, M.R. AU - Cardellina II JH TI - Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii [Language: en] JO - Journal of Natural Products PY - 1999/01/01/ VL - 62 IS - 1 SP - 130 EP - 132 SN - 01633864 AV - Location: *US (DNAL 442.8 L77); Number: 1999004127 N1 - Database Contributor: AGRIS; AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; COMPOSITE RECORD. Database Contributor ID: US1999004127; ALNAP-008457. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US1999004127. Author Affiliation: Fuller, R.W. : National Cancer Institute, Frederick, MD 1; AB - ALNAP Abstract: The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F(1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin (4). This is the first report of this compound type in the genus Allanblackia KW - Africa KW - Tanzania KW - Africa KW - Tanzania KW - tanzania KW - guttiferae KW - drug plants KW - roots KW - wood KW - chemical composition KW - benzoic acid KW - spectrometry KW - chemical structure KW - mankind KW - herpetoviridae KW - antimicrobial properties KW - tanzanie KW - plante medicinale KW - racine KW - bois KW - composition chimique KW - acide benzoique KW - spectrometrie KW - structure chimique KW - genre humain KW - propriete antimicrobienne KW - plantas medicinales KW - raices KW - madera KW - composicion quimica KW - acido benzoico KW - espectrometria KW - estructura quimica KW - genero humano KW - propiedades antimicrobianas KW - clusiaceae KW - derivatives KW - spectral analysis KW - human immunodeficiency virus KW - antiviral properties KW - activity KW - Africa KW - benzophenone KW - bioassay-guided KW - compound KW - extract KW - extracts KW - Fractionation KW - Genus KW - new KW - NMR KW - NMR analysis KW - report KW - structure KW - via UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US1999004127&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Quinn, T C TI - Population migration and the spread of types 1 and 2 human immunodeficiency viruses JO - National Academy of Sciences of the United States of America. Proceedings PY - 1994/01/01/ VL - 91 IS - 7 SP - 2407 EP - 2414 SN - 00278424 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; AIDS CONSORTIUM Location: AIDS Consortium Resource Centre; DEMOGRAPHY. Database Contributor: MEDLINE; AIDS CONSORTIUM RESOURCE CENTRE DATABASE; COMPOSITE RECORD. Database Contributor ID: 8146131; Legal-199600944. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 8146131. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 1; AB - MEDLINE Abstract: Over 14 million people are estimated to be infected with the human immunodeficiency viruses (HIV), with nearly three-fourths of the infected persons residing in developing countries. One factor responsible for dissemination of both HIV-1 and HIV-2 worldwide was the intense migration of individuals, from rural to urban centers with subsequent return migration and internationally due to civil wars, tourism, business purposes, and the drug trade. In sub-Saharan Africa, between 1960 and 1980, urban centers with more than 500,000 inhabitants increased from 3 to 28, and more than 75 military coups occurred in 30 countries. The result was a massive migration of rural inhabitants to urban centers concomitant with the spread of HIV-1 to large population centers. With the associated demographic, economic, and social changes, an epidemic of sexually transmitted diseases and HIV-1 was ignited. Migratory patterns were also responsible for the spread of endemic HIV-2 to neighboring West African countries and eventually to Europe, the Americans, and India. Although Southeast Asia was the last region in which HIV-1 was introduced, it has the greatest potential for rapid spread due to population density and inherent risk behaviors. Thus, the migration of poor, rural, and young sexually active individuals to urban centers coupled with large international movements of HIV-infected individuals played a prominent role in the dissemination of HIV globally. The economic recession has aggravated the transmission of HIV by directly increasing the population at risk through increased urban migration, disruption of rural families and cultural values, poverty, and prostitution and indirectly through a decrease in health care provision. Consequently, social and economic reform as well as sexual behavior education need to be intensified if HIV transmission is to be controlled KW - DEMOGRAPHY KW - AFRICA KW - UNITED STATES OF AMERICA KW - ASIA KW - DEMOGRAPHY KW - AFRICA KW - UNITED STATES OF AMERICA KW - ASIA KW - DEMOGRAPHY KW - EPIDEMIOLOGY KW - MIGRANT WORKERS KW - IMMIGRANTS KW - REFUGEES KW - TRAVEL AND TRAVELLERS KW - HIV-1 KW - HIV-2 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8146131&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Cardellina, J H., 2nd AU - Beutler, J.A. AU - Kashman, Y. AU - Tischler, M. AU - Cardellina, J.H. II. AU - Gray, G.N. AU - Currens, M.J. AU - Wall, M.E. AU - Wani, M.C. AU - Boyd, M.R. TI - A reinvestigation of Maprounea triterpenes [Language: en] JO - Journal of Natural Products PY - 1995/07/01/ VL - 58 IS - 7 SP - 1039 EP - 1046 SN - 01633864 AV - Location: *US (DNAL 442.8 L77); Number: 9559717 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 37558-16-0. Database Contributor: MEDLINE; AGRIS; COMPOSITE RECORD. Database Contributor ID: 7561897; US9559717. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: 7561897. Author Affiliation: Beutler, J.A. : National Cancer Institute, Frederick, MD 1; Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA 2; AB - MEDLINE Abstract: Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group KW - drug plants KW - central african republic KW - euphorbiaceae KW - spectrometry KW - chemical composition KW - triterpenoids KW - mankind KW - herpetoviridae KW - antiviral agents KW - esters KW - reverse transcriptase KW - enzyme inhibitors KW - plante medicinale KW - republique centrafricaine KW - spectrometrie KW - composition chimique KW - triterpenoide KW - genre humain KW - antiviral KW - ester KW - transcriptase inverse KW - inhibiteur d'enzyme KW - plantas medicinales KW - republica centroafricana KW - espectrometria KW - composicion quimica KW - triterpenoidos KW - genero humano KW - viricidas KW - esteres KW - transcriptasa inversa KW - inhibidores de enzimas KW - phorbol KW - maprounea membranaceae KW - maprounea africana KW - molecular structure KW - medicinal plants KW - spectral analysis KW - molecular conformation KW - human immunodeficiency virus KW - binding site UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7561897&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Blasco, R. AU - Lopez-Otin, C. AU - Munoz, M. AU - Bockamp, E.O. AU - Simon-Mateo, C. AU - Vinuela, E. AU - López-Otín, C AU - Muñóz, M AU - Simón-Mateo, C AU - Viñuela, E TI - Sequence and evolutionary relationships of African swine fever virus thymidine kinase [Language: en] JO - Virology PY - 1990/09/01/ VL - 178 IS - 1 SP - 301 EP - 304 SN - 00426822 AV - Location: US; Number: 9112435 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; EC Number: 2.7.1.21; Molecular Sequence: GENBANK/M31715. Database Contributor: AGRIS; MEDLINE; COMPOSITE RECORD. Database Contributor ID: US9112435; 2389555. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9112435. Author Affiliation: Blasco, R. : National Institute of Allergy and Infectious Diseases, NIH 1; Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Canto Blanco, Madrid, Spain 2; AB - MEDLINE Abstract: The thymidine kinase gene of African swine fever virus was mapped in a 1.4-kb EcoRI-PstI fragment located in the left half of the Eco RI K fragment of African swine fever virus DNA by using degenerate oligonucleotide probes derived from regions of the thymidine kinase sequence conserved in several poxviruses, man, mouse, and chicken. The nucleotide sequence of this region revealed an open reading frame of 196 codons, whose translated amino acid sequence showed significant similarity to the thymidine kinases of vaccinia virus, variola virus, monkeypox virus, shope fibroma virus, fowlpox virus, capripox virus, man, mouse, and chicken. The similarity scores obtained after comparison of known thymidine kinase sequences indicated that the African swine fever virus thymidine kinase is more distantly related than the poxvirus thymidine kinases to their cellular homologs. The evolutionary implications of these findings are discussed KW - african swine fever virus KW - transferases KW - nucleotides KW - dna KW - nucleotide sequence KW - genes KW - phylogeny KW - virus peste porcine africaine KW - transferase KW - nucleotide KW - adn KW - sequence nucleique KW - gene KW - phylogenie KW - virus de la peste porcina africana KW - transferasas KW - nucleotidos KW - secuencia nucleica KW - filogenia KW - amino acid sequences KW - dna sequencing KW - gene mapping UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US9112435&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Schwan, T.G. TI - Sex ratio and phoretic mites of fleas [Siphonaptera: Pulicidae and Hystrichopsyllidae] on the Nile grass rat [Arvicanthis niloticus] in Kenya [Language: en] JO - Journal of Medical Entomology PY - 1993/01/01/ VL - 30 IS - 1 SP - 122 EP - 135 SN - 00222585 AV - Location: *US (DNAL 421 J828); Number: 9409687 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: AGRIS; MEDLINE; COMPOSITE RECORD. Database Contributor ID: US9409687; 8433319. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9409687. Author Affiliation: Schwan, T.G. : National Institute of Allergy and Infectious Diseases, Hamilton, MT 1; Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840 2; AB - The sex ratio of fleas and their phoretic mites associated with the Nile grass rat, Arvicanthis niloticus (Desmarest), were studied during 14 mo in a grassland community of Lake Nakuru National Park, Kenya. Females of the fleas Dinopsyllus lypusus jordan and Rothschild, Ctenophthalmus calceatus cabirus Jordan and Rothschild, and Xenopsylla cheopis bantorum Jordan infested more grass rats and in greater numbers than did males. Phoretic hypopi (heteromorphic deutonymphs) of two species of mites, Psylloglyphus uilenbergi Fain and Paraceroglyphus xenopsylla Fain and Schwan, varied seasonally in their abundance on fleas and utilized female fleas over male fleas for their major source of transport. Additionally, the mites were very host specific with nearly 100% of those identified on D. lypusus and C. calceatus cabirus being P. uilenbergi and 89% of the mites identified on X. cheopis bantorum being P. xenopsylla. This level of specificity suggests that these mite-flea associations are highly evolved. The importance of female fleas as hosts for transporting mites also suggests that female-biased sex ratios of fleas on their hosts may be caused, in part, by females being more important as dispersers within flea populations KW - kenya KW - acarina KW - pulicidae KW - hystrichopsyllidae KW - insecte nuisible KW - sex ratio KW - rodentia KW - relation hote parasite KW - kenia KW - insectos daninos KW - proporcion de los sexos KW - relaciones huesped parasito UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US9409687&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - MOFENSON, Lynne M TI - Short-course zidovudine for prevention of perinatal infection JO - Lancet PY - 1999/01/01/ VL - 353 IS - 9155 SP - 766 EP - 767 N1 - Note: CAS Registry Number: 4B9XT59T7S. Database Contributor: HEALTHLINK WORLDWIDE; MEDLINE; COMPOSITE RECORD. Database Contributor ID: HEALTHLINK-023537; 10459952. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: HEALTHLINK-023537. Author Affiliation: Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA 1; AB - MEDLINE Abstract: In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) protocol 076 showed that a 6-week course of zidovudine, given to the mother during pregnancy and labor, and then to the neonate for 6 weeks, reduced HIV transmission rates by almost 70%. The adoption of this regimen in the US and Europe has caused perinatal HIV transmission rates to decline to 6% or less, while transmission rates of 2% have been reported when zidovudine prophylaxis is combined with elective cesarean delivery. However, in absolute terms, the impact of perinatal HIV transmission prevention measures will be greater in developing than in industrialized countries, in part because the overall level of HIV infection among pregnant women in developing countries is far higher than the overall level in industrialized countries. While trials must continue to identify simpler and more cost-effective HIV prevention measures, effort must still be given to implementing the already proven effective regimens in developing countries. To implement short-course HIV prophylactic regimens requires available and accessible antenatal care, HIV testing and follow-up for pregnant women, available and affordable zidovudine, and patient compliance with the drug regimen. To ensure intrapartum zidovudine administration, deliveries must be attended by professional birth attendants. Then, to prevent postpartum HIV transmission, there must be a safe and effective strategy for reducing the risk of HIV-1 transmission through breast milk KW - diseases and disease control KW - hiv [aids] KW - diseases and disease control KW - hiv [aids] KW - antenatal care KW - breastfeeding KW - drug research KW - drug treatment KW - health costs KW - HIV KW - HIV prevention KW - transmission KW - transmission - maternal KW - zidovudine UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=HEALTHLINK-023537&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Daly JW TI - Thirty Years of Discovering Arthropod Alkaloids in Amphibian Skin JO - Journal of Natural Products PY - 1998/01/01/ VL - 61 IS - 1 SP - 162 EP - 172 SN - 01633864 N1 - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]; COMPOSITE RECORD. Database Contributor ID: ALNAP-013492; ALNAP-013601. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-013492. Author Affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 (John William Daly) 1; AB - ALNAP Abstract: Amphibian skin has provided a wide range of biologically active alkaloids. During the past 30 years, over 400 alkaloids of over 20 structural classes have been detected. These include the batrachotoxins, which are potent and selective activators of sodium channels, the histrionic- otoxins, which are potent noncompetitive blockers of nicotinic receptor-gated channels, the pumiliotoxins and related allo- and homo-pumiliotoxins, which have myotonic and cardiotonic activity due to effects on sodium channels, and epibatidine, which has potent antinociceptive activity due to agonist activity at nicotinic receptors. Further classes of alkaloids from amphibian skin include pyrrolidines and piperidines, decahydroquinolines, pyrrolizidines, various indolizidines, quinolizidines, and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines, and cyclopentaquinolizidines. Most alkaloids of amphibian skin appear to be sequestered from dietary arthropods. The source of the batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, and certain izidines are unknown.; Amphibian skin has provided a wide range of biologically active alkaloids. During the past 30 years, over 400 alkaloids of over 20 structural classes have been detected. These include the batrachotoxins, which are potent and selective activators of sodium channels, the histrionicotoxins, which are potent knoncompetitive blockers of nicotinic receptor-gated channels, the pumiliotoxins and related allo-and homo-pumiliotoxins, which have myotonic and carodiotonic activity due to effects on sodium channels, and epibatidine, which hs potent antinociceptive activity due to agonist activity at nicotinic receptors. Furhter classes of alkaloids from amphibian skin include pyrrolidines and piperidines, decahydroquinlines, pyrrolizidines, various indloizidines, quinolizidines, and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines, and cyclopentaquinolizidines. Most alkaloids of amphibian skin appear to be sequestered from dietary arthropods. The source of the batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, and certain izidines are unknown KW - Maryland KW - England KW - Maryland KW - England KW - activity KW - alkaloid KW - Alkaloids KW - Antinociceptive KW - Antinociceptive activity KW - Arthropod KW - Batrachotoxin KW - Biologically KW - cardiotonic KW - chemistry KW - diabetes KW - diseases KW - effect KW - health KW - Histrionicotoxin KW - indolizidine KW - Indolizidines KW - kidney KW - laboratory KW - Nicotinic receptor KW - Oxime KW - piperidine KW - Piperidines KW - Pyrrolidines KW - pyrrolizidine KW - pyrrolizidines KW - quinolizidine KW - related KW - Selective KW - skin KW - sodium UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=ALNAP-013492&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Tsai, W-P AU - Kung, H-F. AU - Nara, PL. TI - The presence and absence of histocompatibility antigens in HIV Type 1 produced by autologous blood-derived macrophages and peripheral blood lymphoblasts JO - AIDS Research and Human Retroviruses PY - 1999/01/01/ VL - 15 IS - 1 SP - 33 EP - 41 PB - Mary Ann Liebert, Inc. Publishers: 140 Huguenot Street, 3rd Floor, New Rochelle, New York, 10801-5215, USA SN - 08892229 N1 - Note: HEALTHLIT Location: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. Database Contributor: HEALTHLIT; AFRICAN DEVELOPMENT DATABASE; COMPOSITE RECORD. Database Contributor ID: 923405. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 923405. Author Affiliation: [1999] - Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA 1; Locations: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. AB - AFRICAN DEVELOPMENT Abstract: Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic isolate, HIV-1ADA, grown from autologous monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs). A virus precipitation assay (VPA) demonstrated that HIV-1ADA grown from PBMCs incorporated substantial amounts of HLA class I (alpha chain and beta2m) and DR antigens, comparable with a laboratory strain, HIV-1MN, grown from the same host cells. HIV-1ADA, however, grown from MDMs incorporated significantly lower amounts of HLAI and-II antigens despite the fact that the infected MDMs were found to express significant amounts of HLA antigens. The lack of incorporation of these important immunomodulatory cell surface proteins may be yet another unique characteristic of macrophage-tropic isolates and suggests a possible role in their biology and or immunology KW - Bacteria / Fungi / Viruses KW - Laboratory experiments KW - Biochemistry / Molecular biology KW - Microbiology / Biotechnology KW - Genetics / Strains / Stock identification KW - North America KW - United States KW - Maryland KW - Bacteria / Fungi / Viruses KW - Laboratory experiments KW - Biochemistry / Molecular biology KW - Microbiology / Biotechnology KW - Genetics / Strains / Stock identification KW - North America KW - United States KW - Maryland KW - hiv-1 antigens KW - blood-derived macrophages KW - antigens KW - immunology KW - host cells KW - virus physiology KW - autogolous macrophages KW - t cells KW - cellular proteins KW - blood lymphoblasts KW - hiv-1 [human immunodeficiency virus type 1] KW - hiv-1 virions KW - histocompatibility UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=923405&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Jain, P. AU - Garraffo, H.M. AU - Yeh, H.J.C. AU - Spande, T.F. AU - Daly, J.W. AU - Andriamaharavo, N.R. AU - Andriantsiferana, M. TI - A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog [Mantella] [Language: en] JO - Journal of Natural Products PY - 1996/12/01/ VL - 59 IS - 12 SP - 1174 EP - 1178 SN - 01633864 AV - Location: *US (DNAL 442.8 L77); Number: 9706599 N1 - Database Contributor: AGRIS. Database Contributor ID: US9706599. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9706599. Author Affiliation: Jain, P. : National Institutes of Health, Bethesda, MD 1; KW - madagascar KW - frogs KW - skin KW - chemical composition KW - alkaloids KW - spectrometry KW - chemical structure KW - chemistry KW - grenouille KW - peau KW - composition chimique KW - alcaloide KW - spectrometrie KW - structure chimique KW - chimie KW - rana KW - piel [animal] KW - composicion quimica KW - alcaloides KW - espectrometria KW - estructura quimica KW - quimica KW - quinolizidine alkaloids KW - spectral analysis KW - stereochemistry UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US9706599&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Rockey, D.D. AU - Chesebro, B.B. AU - Heinzen, R.A. AU - Hackstadt, T. TI - A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. and Chlamydia trachomatis - cloning and characterization of the C. psittaci mip-like gene [Language: en] JO - Microbiology PY - 1996/01/01/ VL - 142 IS - 4 SP - 945 EP - 953 AV - Location: GB; Number: 9625179 N1 - Database Contributor: AGRIS. Database Contributor ID: GB9625179. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB9625179. Author Affiliation: Hackstadt, T. : Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840 USA 1; KW - guinea pigs KW - conjunctivitis KW - gene expression KW - nucleotide sequence KW - chlamydia psittaci KW - viruses KW - proteins KW - cobaye KW - conjonctivite KW - expression des genes KW - sequence nucleotidique KW - virus KW - proteine KW - cobaya KW - conjuntivitis KW - expresion genica KW - secuencia nucleotidica KW - proteinas KW - epitopes UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=GB9625179&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Magrath, I T TI - African Burkitt's lymphoma. History, biology, clinical features, and treatment JO - The American journal of pediatric hematology/oncology PY - 1991/01/01/ VL - 13 IS - 2 SP - 222 EP - 246 SN - 01928562 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2069232. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2069232. Author Affiliation: Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Dennis Burkitt's first description of the African tumor that is now known by his name appeared in 1958. In the brief intervening span of 32 years, this lymphoma has provided an extraordinarily valuable paradigm that has afforded insights into topics that encompass the entire discipline of oncology. These include the origins of lymphoid neoplasms at epidemiological, cellular, and molecular levels, and the efficacy of chemotherapy in rapidly progressive, widely disseminated lymphomas. In addition, epidemiological considerations led to the discovery of a new virus, the Epstein-Barr virus, which has proved to be an important human pathogen. This virus probably plays a pathogenetic role in several neoplastic diseases, including the lymphoproliferative syndromes associated with inherited and acquired immunodeficiency. Small, noncleaved cell lymphoma is the latest histological designation of the category of lymphomas that includes Burkitt's lymphoma. This tumor, which is biologically heterogeneous, has become notorious because of its high incidence in individuals infected with the human immunodeficiency virus, which is providing a second, potentially fertile model for the exploration of the pathogenesis of lymphoid neoplasms. Already, enough is known of the pathogenesis of Burkitt's lymphoma to permit the first tentative steps toward the development of novel therapeutic approaches directed toward the molecular genetic abnormalities associated with the neoplasm. In this article, the history, biology, clinical features, and treatment of African Burkitt's lymphoma are reviewed UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2069232&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Williams, J K TI - Afro-American women living with HIV infection: special therapeutic interventions for a growing population JO - Social Work in Health Care PY - 1995/01/01/ VL - 21 IS - 2 SP - 41 EP - 53 SN - 00981389 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8553198. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8553198. Author Affiliation: HIV Counseling Program, National Institutes of Health, Bethesda, MD, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8553198&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Biggar, R J TI - AIDS and HIV infection: estimates of the magnitude of the problem worldwide in 1985/1986 JO - Clinical Immunology and Immunopathology PY - 1987/01/01/ VL - 45 IS - 3 SP - 297 EP - 309 SN - 00901229 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3677488. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3677488. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: This review summarizes observations about the distribution of AIDS and HIV infection throughout the world. The United States has reported the greatest number of cases to the World Health Organization (WHO), but data from many areas are lacking or incomplete, making comparisons between different areas unreliable. Even within the United States, data are difficult to interpret and require careful consideration of the size of the various HIV-risk groups in the population and the degree to which results of studies of selected cohorts within a risk group can be extrapolated to the whole of that population. Outside of the United States, Europe, and Australia, less information is available. Almost every country in South America has reported cases of AIDS, although in most reports the number is small. In Asia, many countries have not yet reported cases or have had only a small number of cases. By the end of 1986, many countries in Africa had not yet reported any AIDS cases to the WHO, even from areas where AIDS is known to occur (i.e., Zaire). However, there is ample evidence from regional studies in Africa that AIDS and HIV infection are a major public health problem. Using admittedly questionable information for estimating the size of the problem worldwide, I project that between two and three million persons worldwide were infected with HIV by 1985/1986. Despite the lack of an effective therapy or vaccine, much can be and is being done to limit the global spread of HIV infection and AIDS UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3677488&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Biggar, R J TI - AIDS in subsaharan Africa JO - Cancer detection and prevention. Supplement: official publication of the International Society for Preventive Oncology, Inc PY - 1987/01/01/ VL - 1 SP - 487 EP - 491 SN - 10436995 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3480062. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3480062. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205 1; AB - MEDLINE Abstract: AIDS has existed in subsaharan Africa at least since 1980. However, the genesis of this condition and its emergence as a health problem remain obscured by lack of data and by antibody data that are now questionable. In Africa, as elsewhere, AIDS is associated with an immunodeficiency associated with the LAV/HTLV-III retrovirus. The clinical manifestations vary somewhat because of the different range of opportunistic pathogens in that environment. Although the "classical," more indolent, endemic form of African Kaposi sarcoma is not associated with this virus or with immunodeficiency, a new, aggressive variety of Kaposi sarcoma in Africa appears to be. The origin of LAV/HTLV-III remains unclear, but the clinical syndrome of AIDS has emerged in Africa only in the past decade. A pattern of geographic spread can be recognized, in which AIDS was seen earliest in Kinshasa, Zaïre, and then emerged in Zambia, Rwanda, and Uganda. Recently, reports indicate spread into Tanzania and Kenya. Transmission appears to be primarily heterosexual, but the factors enhancing heterosexual spread in Africa to a greater extent than in the U.S. and Europe need to be further studied UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3480062&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Willoughby, A TI - AIDS in women: epidemiology JO - Clinical Obstetrics and Gynecology PY - 1989/01/01/ VL - 32 IS - 3 SP - 429 EP - 436 SN - 00099201 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2776374. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2776374. Author Affiliation: National Institute of Child Health and Human Development, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Several facts concerning the distribution of AIDS in U.S. female populations are clear. This disease has made significant inroads, in a quantitative sense, into the female segment of our society as documented by AIDS surveillance data, information on pregnant women and parturients, and by screening data from the military. The impact on women in the reproductive years, on the reproductive health of these women, and on the reproductive outcome of their pregnancies is of substantial concern. Monitoring epidemiologic trends in certain groups will require clever and creative strategies like those of Hoff and colleagues. Additional data may be derived from the CDC's Family of Surveys that will examine HIV prevalence in five groups (in addition to the newborn infant survey described above): intravenous drug users, patients admitted to hospitals, sexually transmitted disease clinic patients, women's health and reproductive health clinics, and tuberculosis clinics. It is hoped that the data obtained from these studies, as well as data gathered on college students and Job Corps applicants, will contribute additional information on HIV infection in women. Monitoring the progress of the AIDS epidemic in women will be difficult. Even more difficult will be the effort to respond to the epidemic in the women it most frequently affects: the poor, minority, disenfranchised women who may be involved in illegal activities (drug use, prostitution, illegal immigration) who are not well networked into the medical and social services of our society UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2776374&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Cohen, S G TI - Al-Afdal [1169-1225] Arab Sultan of Damascus and Egypt JO - Allergy proceedings: the official journal of regional and state allergy societies PY - 1995/01/01/ VL - 16 IS - 4 SP - 214 EP - 215 SN - 10469354 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Named Person: Al-Afdal. Database Contributor: MEDLINE. Database Contributor ID: 8566731. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8566731. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8566731&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Bokesch HR AU - Blunt JW AU - Westergaard CK AU - Cardellina II JH AU - Johnson TR AU - Michael JA AU - Mckee TC AU - Hollingshead MG AU - Boyd MR TI - Alertenone, a Dimer of Suberosenone from Alertigorgia sp JO - Journal of Natural Products PY - 1999/01/01/ VL - 62 IS - 4 SP - 633 EP - 635 SN - 01633864 N1 - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-013929. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-013929. Author Affiliation: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederrick, Maryland 21702-1201 (Michael R. Boyd) 1; AB - ALNAP Abstract: Bioassay-guided fractionation of organic extracts of the gorgonian Alertigorgia sp. has yielded the previously known suberosenone (1), a cytotoxic tricyclic sesquiterpene of the quadrone class, and alertenone (2), a climer of suberosenone. The structure of 2 was determined by spectral analysis; the 1D TOCSY experiment was particularly useful in the structure elucidation. Comparison of the in vitro cytotoxicity of alertenone and suberosenone revealed that the dimeric alertenone was devoid of cytotoxicity below 35 mg/mL. In a hollow-fiber assay model of in vivo activity, suberosenone eXhibited some growth inhibition of two of six tumor cell lines tested KW - Australia KW - Australia KW - activity KW - analysis KW - Australia KW - bioassay-guided KW - cancer KW - cancer treatment KW - cell KW - cell line KW - cytotoxic KW - cytotoxicity KW - development KW - dimer KW - Division KW - drug KW - drug discovery KW - elucidation KW - experiment KW - extract KW - extracts KW - Fractionation KW - Gorgonian KW - growth KW - growth inhibition KW - in vitro KW - in vitro cytotoxicity KW - in vivo KW - inhibition KW - laboratory KW - organic KW - organic extract KW - Organic extracts KW - research KW - Sesquiterpene KW - SP KW - spectral analysis KW - structure KW - structure elucidation KW - therapeutic KW - therapeutics KW - treatment KW - vivo UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=ALNAP-013929&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Berzofsky, J A TI - Antigenic peptide interaction with MHC molecules: implications for the design of artificial vaccines JO - Seminars in Immunology PY - 1991/01/01/ VL - 3 IS - 4 SP - 203 EP - 216 SN - 10445323 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1932704. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1932704. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814 1; AB - MEDLINE Abstract: Both helper and cytotoxic T cells see primarily a limited number of immunodominant sites on a protein. The reasons for immunodominance are many. We have explored primarily the roles of antigen processing and binding to histocompatibility molecules, as well as the structural features of the antigenic peptide. This information has led to the identification and characterization of sites stimulating helper or cytotoxic T cells specific for antigens from malaria or HIV, and ways to couple and immunize with these, that may be useful for vaccine development. We also observed a striking concordance between helper and cytotoxic T cell sites UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1932704&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rabkin, C S TI - Association of non-acquired immunodeficiency syndrome-defining cancers with human immunodeficiency virus infection JO - National Cancer Institute. Journal. Monographs PY - 1998/01/01/ IS - 23 SP - 23 EP - 25 SN - 10526773 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9709298. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9709298. Author Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA 1; AB - MEDLINE Abstract: Kaposi's sarcoma and non-Hodgkin's lymphoma were among the earliest recognized manifestations of the acquired immunodeficiency syndrome (AIDS) epidemic. Excluding these two tumors, the overall risk of all other cancers in human immunodeficiency virus (HIV)-infected individuals is similar to that of the general population. However, varying levels of evidence link several additional neoplasms to HIV infection. The evidence is strongest for an association with Hodgkin's disease, with lower relative and absolute risks than for non-Hodgkin's lymphoma. Anogenital intraepithelial neoplasia also appears to be HIV associated, but increases of invasive disease are still uncertain for both cervical and anal cancers. Various studies have suggested associations with testicular seminoma, multiple myeloma, oral cancer, and melanoma, but the data are inconsistent. Leiomyosarcoma and benign leiomyomas have increased in incidence in HIV-infected children but are unusual in HIV-infected adults. Conjunctival carcinoma is seen in HIV-infected individuals in sub-Saharan Africa but it is uncommon in Western countries. Most other cancers do not seem to have increased incidences in HIV infection. The etiologic mechanisms of HIV-related cancer likely differ among these diverse cancers and do not globally increase cancer risk UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9709298&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Cohen, S G TI - Asthma among the famous. Adb el-Kader [1808-1883], founder of the Algerian state JO - Allergy and Asthma Proceedings PY - 1997/01/01/ VL - 18 IS - 1 SP - 50 EP - 52 SN - 10885412 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Named Person: el-Kader. Database Contributor: MEDLINE. Database Contributor ID: 9162573. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9162573. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9162573&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Stevens, J TI - Brief psychoses: do they contribute to the good prognosis and equal prevalence of schizophrenia in developing countries JO - British Journal of Psychiatry PY - 1987/01/01/ VL - 151 SP - 393 EP - 396 SN - 00071250 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3427295. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3427295. Author Affiliation: National Institute of Mental Health, St Elizabeth's Hospital, Washington D.C. 20032 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3427295&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Tawfik, H N TI - Carcinoma of the urinary bladder associated with schistosomiasis in Egypt: the possible causal relationship JO - Princess Takamatsu symposia PY - 1987/01/01/ VL - 18 SP - 197 EP - 209 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3147281. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3147281. Author Affiliation: Department of Pathology, National Cancer Institute, Cairo University, Egypt 1; AB - MEDLINE Abstract: Carcinoma of the urinary bladder is the most common malignancy in Egyptians. At the National Cancer Institute in Cairo, it accounts for 27.6% of all cancers--38.5% of cancers in the male and 11.3% in the female. This very high frequency is attributed to underlying schistosomiasis. The infection can lead to malignancy through local tissue damage, mechanical irritation, bilharzial toxins or through secondary bacterial infection. Bacterial products include nitrate reductase capable of synthesizing nitrosoamines and beta glucuronidase enzymes, active at pH 7. Through liver involvement and dysfunction, tryptophan metabolism is disturbed, with the excretion of carcinogenic metabolites. Vitamin A deficiency is responsible for the squamous metaplasia and the high frequency of squamous cell carcinoma observed in the bladder. The characteristic clinico-pathological features of cancer of the urinary bladder are outlined, mainly the occurrence at a young age, the male predominance, especially farmers, and the high association with schistosomiasis. The tumors are often first seen in an advanced stage, arising from the posterior bladder wall and vault. The trigone is only affected in 8.5% of the cases. Histologically, squamous cell carcinomas of low grade are the most frequent cell type. Lymph node involvement is low in spite of the advanced stage of the tumor. Therefore, the results of radical surgery are encouraging. The results of a special study correlating the above parameters with the intensity of ova deposition are presented. Patients with heavy infection at a slightly earlier age but other tumor parameters the same are similar to those of egg-negative cases. This study indicates that other factors also play a role in the induction of tumors that are enhanced by the schistosomal infection. In Fayoum Province, schistosomiasis is decreasing while bladder cancer is increasing. Urine cytology as a screening tool is effective in detecting early bladder cancer. Studies are now in progress to detect tumor associated antigens in sera and urine of patients UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3147281&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Miller, L H TI - The challenge of malaria JO - Science PY - 1992/01/01/ VL - 257 IS - 5066 SP - 36 EP - 37 SN - 00368075 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1621092. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1621092. Author Affiliation: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1621092&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Harris, C C TI - Chemical and physical carcinogenesis: advances and perspectives for the 1990s JO - Cancer Research PY - 1991/01/01/ VL - 51 IS - 18 Suppl SP - 5023s EP - 5044s SN - 00085472 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; Genome Sequence: Ha-ras; Ki-ras; Rb; aprt; dhfr; ras. Database Contributor: MEDLINE. Database Contributor ID: 1884379. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1884379. Author Affiliation: Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal expansion as the result of activation of protooncogenes and/or inactivation of tumor suppressor genes. Therefore, the mutational spectra of chemical and physical carcinogens in these critical genes are of interest to define endogenous and exogenous mutational mechanisms. The p53 tumor suppressor gene is ideally suited for analysis of the mutational spectrum. Such an analysis has revealed evidence for both exogenous and endogenous molecular mechanisms of carcinogenesis. For example, an informative p53 mutational spectrum of frequent G----T transversions in codon 249 is found in hepatocellular carcinomas from either Qidong, People's Republic of China, or southern Africa. This observation links exposure to aflatoxin B1, a known cancer risk factor in these geographic regions, with a specific mutation in a cancer-related gene. Other studies indicate that abnormalities in genes controlling the cell cycle may cause genomic instability and increase the probability of neoplastic transformation. Finally, mechanistic understanding of carcinogenesis is leading to improved cancer risk assessment and to the identification of individuals at high cancer risk UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1884379&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Murphy, P M TI - Chemokine receptors: structure, function and role in microbial pathogenesis JO - Cytokine and Growth Factor Reviews PY - 1996/01/01/ VL - 7 IS - 1 SP - 47 EP - 64 SN - 13596101 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 8864354. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8864354. Author Affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; AB - MEDLINE Abstract: The chemokine superfamily is composed of at least 20 different leukocyte chemoattractants that act by binding to a family of G protein-coupled receptors. Leukocyte subtypes respond preferentially to unique but overlapping subsets of chemokines as determined by the receptor distribution, yet the receptors appear to signal through a common Gi-type G protein. Since chemokines appear to play major roles in inflammatory pathology, their receptors may be good targets for developing leukocyte selective anti-inflammatory drugs. Two chemokine receptors, CC CKRS and ONCC, function pathologically as cell entry factors respectively for human immunodeficiency virus 1, the cause of AIDS, and Plasmodium vivax, the major cause of malaria UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8864354&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Nussenblatt, R B TI - Clinical studies of Vogt-Koyanagi-Harada's disease at the National Eye Institute, NIH, USA JO - Japanese Journal of Ophthalmology PY - 1988/01/01/ VL - 32 IS - 3 SP - 330 EP - 333 SN - 00215155 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3230719. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3230719. Author Affiliation: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: We have, in the recent past, seen 46 Vogt-Koyanagi-Harada's disease patients at the National Eye Institute. Most of these patients have been women, and a high percentage were Black-American or Hispanic. However, an interesting observation has been American Indian antecedents for a large number of these patients, whether they considered themselves Black or Caucasian. The visual acuities tended to be at the extremes of the vision chart. Patients with this disorder appear to have circulating autoantibodies to the retinal photoreceptor region, and these autoantibodies do not appear to be directed against the retinal S-antigen UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3230719&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Harrington, M G AU - Kennedy, P G TI - The clinical use of cerebrospinal fluid studies in demyelinating neurological diseases JO - Postgraduate Medical Journal PY - 1987/01/01/ VL - 63 IS - 743 SP - 735 EP - 740 PB - BMJ Publishing Group LTD SN - 00325473 N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 1197997. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1197997. Author Affiliation: 1987 Year - Biochemical Genetics Section, National Institute of Mental Health, Bethesda, MD 20892, USA 1; AB - HEALTHLIT Abstract: The clinical diagnosis of definite multiple sclerosis is supported by abnormalities in the cerebrospinal fluid: variable mild pleocytosis and elevation of total protein, moderately elevated total IgG in most patients, and the almost invariable presence of discrete immunoglobulins after electrophoresis, the oligoclonal bands. The oligoclonal bands are non-specific, and are seen in most diseases of the nervous system, but their temporal uniformity in each patient with multiple sclerosis is characteristic. Prognostically, patients with a single episode of optic neuritis or paraesthesia who have oligoclonal bands are more likely to develop multiple sclerosis than if the spinal fluid were normal. In the Guillain-Barré syndrome, the spinal fluid total protein is transiently elevated, with no pleocytosis. Oligoclonal bands are usually found in the acute phase and only persist in those patients with chronic or relapsing polyneuropathy KW - Diseases / Pathogens KW - Medical Science KW - Humans KW - Diseases / Pathogens KW - Medical Science KW - Humans KW - multiple sclerosis KW - cerebrospinal fluid KW - pleocytosis KW - oligoclonal bands KW - optic neuritis KW - paraesthesia KW - guillain-barre syndrome KW - polyneuropathy UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1197997&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Alter, H J TI - Clinical, virological and epidemiological basis for the treatment of chronic non-A, non-B hepatitis JO - Journal of Hepatology PY - 1990/01/01/ VL - 11 Su IS - 1 SP - S19 EP - S25 SN - 01688278 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1964164. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1964164. Author Affiliation: Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Non-A, non-B hepatitis is the most common serious complication of blood transfusion and also occurs in a sporadic form whose routes of transmission are currently unknown. While generally mild in its acute presentation, non-A, non-B hepatitis frequently progresses to chronic hepatitis which may eventuate in cirrhosis and hepatocellular carcinoma. The disease is caused by a small, enveloped RNA virus now designated hepatitis C virus, which has similarities to the flaviviruses. Studies using the recently developed antibody assay have indicated that hepatitis C virus is the predominant agent of both transfusion-associated and sporadic non-A, non-B hepatitis. In 50-85% of transfusion-associated cases, a donor can be found who is positive for antibodies to the hepatitis C virus. Current data indicate that these antibodies are present in approx. 0.5% of blood donors in the United States and Europe, 1.5% in Japan and 6% in Africa, as well as in 60-80% of haemophiliacs and intravenous drug abusers and approx. 20% of dialysis patients. With changes in donor selection and transfusion practices, the incidence of transfusion-associated non-A, non-B hepatitis has declined from rates of 5-10% prior to 1985 to estimated current rates of 2-4%. The introduction of the anti-HCV test should effect an additional 50% reduction in transfusion-associated non-A, non-B hepatitis. In addition to these preventive measures, effective therapy now appears at hand in the form of alpha-interferon. The efficacy of other antiviral agents and the potential for combination therapies also need to be explored UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1964164&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Komatsu, K. AU - Oeda, T. AU - Strott, C.A. TI - Cloning and sequence analysis of the 5'-flanking region of the estrogen sulfotransferase gene: steroid response elements and cell-specific nuclear DNA-binding proteins [Language: en] JO - Biochemical and Biophysical Research Communications PY - 1993/01/01/ VL - 194 IS - 3 SP - 1297 EP - 1304 SN - 0006291X AV - Location: GB; Number: 9515839 N1 - Database Contributor: AGRIS. Database Contributor ID: GB9515839. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB9515839. Author Affiliation: Strott, C.A. : Section on Adrenal Cell Biology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA 1; KW - guinea pigs KW - nucleotide sequence KW - enzymes KW - dna KW - proteins KW - oestrogens/ glucocorticoids KW - cobaye KW - sequence nucleique KW - enzyme KW - adn KW - proteine KW - oestrogene/ glucocorticoide KW - cobaya KW - secuencia nucleica KW - enzimas KW - proteinas KW - estrogenos/ glucocorticoides UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=GB9515839&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Knutsen, T TI - Cytogenetic changes in the progression of lymphoma JO - Leukemia and Lymphoma PY - 1998/01/01/ VL - 31 IS - 1-2 SP - 1 EP - 19 SN - 10428194 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: turidk@Box-t.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9720711. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9720711. Author Affiliation: Cytogenetics Laboratory, Experimental Therapeutics Section Medicine Branch, NCI National Institutes of Health, Bethesda, MD, USA 1; AB - MEDLINE Abstract: The study of chromosomal changes related to tumor progression in NHL is complicated by the various histologic classification systems and the lack of large serial studies comparing abnormalities at different disease stages. The T-cell lymphomas frequently involve rearrangements of the T-cell receptors and tumor progression is marked by a change from single cell aberrations and polyclonality in low grade disease to monoclonal formation, complex clones, polyploidy, and abnormalities of 1p, 6q, 7, and 13 in high grade T-NHL. In B-cell NHL, specific translocations and oncogene rearrangements are associated with specific NHL subtypes de novo; many of these translocations involve immunoglobulin genes, such as t(14;18) in follicular lymphoma, t(11;14) in MCL, t(3;14) in DLLC, and t(8;14) in Burkitt's lymphoma. Tumor progression is associated with secondary abnormalities which are generally not confined to a particular NHL subtype. Some abnormalities, such as those involving chromosomes 1, 6, and 17, >4-6 clonal markers/cell, and rearrangements of c-MYC and TP53, have prognostic significance while others, such as trisomies 7, 12, 18, and X, are associated with tumor progression but their influence on overall survival is uncertain UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9720711&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Wynn, T A TI - The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12 JO - Instituto Oswaldo Cruz, Rio de Janeiro. Memorias PY - 1997/01/01/ VL - 92 Su IS - 2 SP - 105 EP - 108 SN - 00740276 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 187348-17-0. Database Contributor: MEDLINE. Database Contributor ID: 9698921. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9698921. Author Affiliation: Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: The production of Th1-type cytokines is associated with strong cell-mediated immunity while Th2-type cytokines are typically involved in the generation of humoral immune responses. In mice vaccinated a single time (1X) with attenuated cercariae of Schistosoma mansoni, the immunity induced is highly dependent on CD4+ T cells and IFN-gamma. In contrast, mice vaccinated multiple times (3X) have decreased IFN-gamma expression, develop a more dominant Th2-type cytokine response as well as protective antibodies which can passively transfer immunity to naive recipients. Previously, we demonstrated the ability of IL-12, a potent IFN-gamma-inducing cytokine to enhance (1X) schistosome cell-mediated saline-treated mice demonstrated a 70 immunity when administered during the period of immunization. More recently, we asked what effects IL-12 would have on the development humoral-based immunity. While multiply-immunized/ saline-treated mice demonstrated a 70-80% reduction in parasite burden, 3X/IL-12-vaccinated animals displayed an even more striking > 90% reduction in challenge infection, with many mice in the later group demonstrating complete protection. Analysis of pulmonary cytokine mRNA responses demonstrated that control challenged mice elicited a dominant Th2-type response, 3X/saline-vaccinated produced a mixed Th1/Th2-type cytokine response, while 3X/IL-12-immunized animals displayed a dominant Th1-type response. The IL-12-treated group also showed a marked reduction in total serum IgE and tissue eosinophilia while SWAP-specific IgG2a and IgG2b Abs were elevated. Interestingly, animals vaccinated with IL-12 also showed a highly significant increase in total Ig titers specific for IrV, a known protective antigen. More importantly, 3X/IL-12 serum transferred significantly less protection. Nevertheless, animals vaccinated in the presence of IL-12 also develop macrophages with enhanced nitric oxide dependent killing activity against the parasites. Together, these observation suggest that IL-12, initially described as an adjuvant for cell-mediated immunity, may also be used as an adjuvant for promoting both humoral and cell-mediated protective responses UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9698921&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Wynn, T A TI - Development of an antipathology vaccine for schistosomiasis JO - New York Academy of Sciences. Annals PY - 1996/01/01/ VL - 797 SP - 191 EP - 195 SN - 00778923 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 187348-17-0; 82115-62-6. Database Contributor: MEDLINE. Database Contributor ID: 8993362. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8993362. Author Affiliation: Immunobiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: The data presented here clearly demonstrate that IL-12 can act as an adjuvant, suppressing both granuloma formation and fibrosis induced after natural schistosome infection. Recently, we showed that IL-12 can increase protective immunity provided by an attenuated larval schistosome vaccine as well. In both cases the vaccines appear to suppress in large part the parasite-induced Th2 responses. Thus, the use of cytokines as adjuvants offers a rational approach for immunomodulation when the effector mechanism of a particular vaccine is known. Clearly, IL-12 has enormous potential for modulating the outcome of immunization and may have broad application in preventing a variety of different infectious diseases UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8993362&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Zaghloul, M S TI - Distant metastasis from bilharzial bladder cancer JO - Cancer PY - 1996/01/01/ VL - 77 IS - 4 SP - 743 EP - 749 SN - 0008543X N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8616767. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8616767. Author Affiliation: Radiotherapy Department, National Cancer Institute, Cairo, Egypt 1; AB - MEDLINE Abstract: BACKGROUND: Distant metastasis is rarely described among bilharzial bladder cancer patients. However, with improved 5-year survival rates following adjuvant local therapy, distant metastasis is now reported with increasing frequency. METHODS: Three-hundred-fifty-seven bilharzial bladder cancer patients were treated at the National Cancer Institute in Cairo, Egypt, during the period 1981-1990. They were treated with either cystectomy alone, cystectomy preceded by a short course of preoperative radiotherapy (2000 cGy/5 fractions/1 week), or cystectomy followed by postoperative irradiation (5000 cGy/25 fractions/5 weeks or 3750 cGy/30 fractions/2 weeks). These patients were retrospectively analyzed. RESULTS: The overall 5-year actuarial rate of distant metastasis was 23% (95% confidence interval, 21-25%), which was essentially the same in the 3 therapeutic groups. Both univariate and multivariate analyses revealed that the independent risk factors for distant metastasis were pelvic lymph node involvement (P = 0.005), pathologic stage (P = 0.004), and histopathologic grade (P = 0.05). Histologic type and local pelvic recurrence appeared in the univariate analysis as working risk factors; however, they were proven by multivariate analysis to be dependent on other risk factors. Patients who had none of the independent risk factors had a lower rate of distant metastasis (II%) and a high local control rate (88%). Those who had more than one risk factor had high distant metastasis rate (51%) and low local control rate (41%), regardless of the therapeutic modality used. The identified independent risk factors determined both the distant metastasis and the local control rates. CONCLUSIONS: Unlike previous reports, this rigorous study of distant metastasis in bilharzial bladder cancer revealed an occurrence rate of 23%. This high rate was associated with pelvic lymph node involvement, pathologic stage, and histopathologic grade. Histologic type, local pelvic recurrence, or the addition of pre- or post-operative radiotherapy proved not to be independent risk factors UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8616767&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Sheu, Y TI - Drug abuse and acquired immune deficiency syndrome JO - Psychiatry and Clinical Neurosciences PY - 1998/01/01/ VL - 52 Su EP - 74 SN - 13231316 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9895137. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9895137. Author Affiliation: Medical Affairs, Division of Clinical Research and Services, National Institute on Drug Abuse, Rockville, Maryland 20857, USA 1; AB - MEDLINE Abstract: Acquired immune deficiency syndrome (AIDS) is a modern plague. The first sign of the disease was the appearance of Pneumocystis carinii and Kaposi's sarcoma among young homosexual patients. The virus transmission is from an infected individual to a susceptible host through blood-related, sexual, and perinatal routes. Exchange of body fluid occurs when sharing syringes, drugs, and drug paraphernalia. Although the largest number of people infected with human immunodeficiency virus (HIV) is in subSaharan Africa, the most rapid growth of HIV infection during the 1990s was seen in South-East Asia. Asia showed a steep increase from 1992. Given the experiences in Thailand, India and China, a similar spread of AIDS in other parts of Asia is possible. The risk behaviors that enable the spread of HIV are present in all Pacific Asian countries. Risk behaviors are considered to be the injection of illicit drugs, male patronage of prostitutes, high rates of sexually transmitted diseases, and low condom use UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9895137&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Tawfik, M O TI - Egypt: status of cancer pain and palliative care JO - Journal of Pain and Symptom Management PY - 1993/01/01/ VL - 8 IS - 6 SP - 409 EP - 411 SN - 08853924 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7525763. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7525763. Author Affiliation: Department of Algology, National Cancer Institute, Cairo University, Egypt 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7525763&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Blot, W J TI - Esophageal cancer trends and risk factors JO - Seminars in Oncology PY - 1994/01/01/ VL - 21 IS - 4 SP - 403 EP - 410 SN - 00937754 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8042037. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8042037. Author Affiliation: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Esophageal cancer displays unique epidemiologic features that distinguish it from all other malignancies. It shows marked geographic variation both internationally, with exceptionally high rates (some of the world's highest for any cancer) in limited areas of Asia, and nationally, with clustering of increased rates within the United States as well. However, the patterns are changing with rates of squamous cell carcinomas decreasing and adenocarcinomas increasing rapidly in several western countries. The causes of the clusters of squamous cell carcinomas in parts of Asia and Africa are not well known, but within the United States and other western countries, tobacco and alcohol consumption are the major determinants. Nutritional factors also may play a major role, with diets high in fresh fruits and vegetables consistently associated with reduced risks. The causes of the rapidly increasing rates of adenocarcinomas of the esophagus, and reasons or its occurrence primarily among white men, are enigmatic. Additional research on the etiology of this emerging cell type is warranted, and may provide information crucial to the development of readily implementable preventive strategies UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8042037&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Miller, L H TI - Evolution of the human genome under selective pressure from malaria: applications for control JO - Parassitologia PY - 1999/01/01/ VL - 41 IS - 1-3 SP - 77 EP - 82 SN - 00482951 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: lmiller@niaid.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 10697836. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10697836. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA 1; AB - MEDLINE Abstract: Research on the molecular basis for resistance of humans to malaria has been vigorous during the last 10 years, with new discoveries and extension of work from previous decades. Much of the work has important implications both for understanding pathogenesis and for applications for control of disease UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10697836&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Nutman, T B TI - Experimental infection of humans with filariae JO - Reviews of Infectious Diseases PY - 1991/01/01/ VL - 13 IS - 5 SP - 1018 EP - 1022 SN - 01620886 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1962076. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1962076. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: This report summarizes the findings of the 17 published studies involving humans who have been experimentally infected with filarial parasites. Over the past 60 years, 45 individuals have been deliberately infected with Wuchereria bancrofti, Brugia malayi, Brugia pahangi, Loa loa, Mansonella perstans, Mansonella ozzardi, and/or Onchocerca volvulus. The findings from these experimental infections of humans have helped define microfilarial survival and periodicity within human hosts, the prepatent period for the causative agents of lymphatic filariasis, etiologic agents for particular clinical syndromes, immunologic and hematologic consequences of filarial infection, and the role of chemotherapeutic agents in the prevention and treatment of filarial infections UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1962076&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - James, S L TI - Experimental models of immunization against schistosomes: lessons for vaccine development JO - Immunological Investigations PY - 1992/01/01/ VL - 21 IS - 5 SP - 477 EP - 493 SN - 08820139 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1428021. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1428021. Author Affiliation: Immunology and Cell Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Schistosomiasis is a debilitating, and sometimes deadly, parasitic infection that afflicts hundreds of millions of people living in developing countries. One of the best hopes for control of this disease is vaccine development. Studies on experimental models of attenuated vaccines have proven that high levels of protective immunity can be achieved. In these systems, resistance has been shown to be directed against the migrating larval stages of the parasite and to have both cellular and humoral components. Several candidate vaccine immunogens have been identified on the basis of antibody reactivity. However, the level of protection induced by immunization with nonliving vaccines has at yet not approached the level observed with attenuated infection. Current challenges to vaccine development include identification of protective T cell immunogens, determination of ways to strengthen the immunogenicity of isolated parasite antigens, and development of methodologies to selectively stimulate protective, as opposed to ineffective or even detrimental, immune responses UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1428021&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Berzofsky, J A TI - Features of T-cell recognition and antigen structure useful in the design of vaccines to elicit T-cell immunity JO - Vaccine PY - 1988/01/01/ VL - 6 IS - 2 SP - 89 EP - 93 SN - 0264410X N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2455388. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2455388. Author Affiliation: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: In contrast to antibodies, T lymphocytes tend to recognize a limited number of immunodominant antigenic sites on a protein antigen. Therefore, the effective design of synthetic or recombinant fragment vaccines would be better approached if these sites could be identified. From studies of the processing and genetically restricted presentation of the model protein antigen myoglobin to murine T cells, certain general principles have emerged which should be useful in this endeavour. The immunodominant sites for helper T cells in model proteins tend to be regions which can fold as alpha-helices and, in particular, helices which are amphipathic, i.e. which have a hydrophobic side and a hydrophilic side separated in space. These two sides may serve to interact with the major histocompatibility molecule on the antigen-presenting cell and with the T-cell receptor, respectively. A computer algorithm has been developed to search for such sites in protein sequences and it has been applied to two proteins of interest for vaccine development, the circumsporozoite protein of Plasmodium falciparum malaria and the envelope protein of the AIDS virus (HIV). Corresponding peptides were synthesized and shown to induce helper and/or proliferative T-cell immunity UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2455388&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Ottesen, E A TI - Filarial infections JO - Infectious Disease Clinics of North America PY - 1993/01/01/ VL - 7 IS - 3 SP - 619 EP - 633 SN - 08915520 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 70288-86-7; V867Q8X3ZD. Database Contributor: MEDLINE. Database Contributor ID: 8254163. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8254163. Author Affiliation: Clinical Parasitology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; AB - MEDLINE Abstract: The seven filarial parasites of humans infect over 100 million people worldwide. These parasites are long lived, with adults living an average of 10 to 15 years and the microfilaria, probably 6 to 12 months. Importantly, as with most other helminth parasites, there is no replication of the adult parasite within the human host so that the extent of infection (that is, the number of adult worms one has) never increases after one leaves an endemic region and ceases to be exposed to the insect-borne infective larvae. This article will discuss the diagnosis and treatment of filarial infections, as well as some recent clinical advances UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8254163&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Ottesen, E A TI - Filariasis now JO - American Journal of Tropical Medicine and Hygiene PY - 1989/01/01/ VL - 41 IS - 3 Suppl SP - 9 EP - 17 SN - 00029637 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2679166. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2679166. Author Affiliation: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2679166&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Gwadz, R W TI - Genetic approaches to malaria control: how long the road JO - American Journal of Tropical Medicine and Hygiene PY - 1994/01/01/ VL - 50 IS - 6 Suppl SP - 116 EP - 125 SN - 00029637 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7912907. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7912907. Author Affiliation: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; AB - MEDLINE Abstract: Malaria control schemes based on the yet untested concept of replacing vector populations with mosquitoes of the same species unable to transmit the parasite offer one more means of attacking this important public health problem. Research is underway in several laboratories aimed at defining factors that can act to interrupt the development of the malaria parasite in the mosquito host, the genetic basis for such refractory mechanisms, methods for introducing genes coding for refractory mechanisms into the mosquito genome, and methods for replacing vector populations in the field. The complexities of such an undertaking are many and varied, but the potential impact of a successful replacement strategy on the epidemiology of malaria in the target area could be significant UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7912907&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Yanagihara, R TI - Hantavirus infection in the United States: epizootiology and epidemiology JO - Reviews of Infectious Diseases PY - 1990/01/01/ VL - 12 IS - 3 SP - 449 EP - 457 SN - 01620886 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1972804. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1972804. Author Affiliation: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Multiple species of murid and arvicolid (microtine) rodents serve as the reservoir hosts of hantaviruses, the etiologic agents of hemorrhagic fever with renal syndrome. Three antigenically distinct hantaviruses have been isolated from Rattus norvegicus, Mus musculus, and Microtus pennsylvanicus captured in the United States, and serologic evidence of a hantavirus enzootic has been found in several other indigenous rodent species. In residential districts of port cities such as Baltimore, nearly 50% of Norway rats are infected with viruses that are serologically indistinguishable from disease-causing Hantavirus strains isolated from rats in the Far East. Despite the widespread distribution of Hantavirus-infected rodents, confirmed cases of hemorrhagic fever with renal syndrome have not been recognized in the United States. Moreover, the overall risk of hantavirus infection in humans in the United States is low, even among individuals who have frequent exposure to commensal and wild rodents. Studies are needed to define the clinical spectrum of hantavirus infection in humans in the United States UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1972804&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Tabor, E TI - Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection JO - Journal of Medical Virology PY - 1989/01/01/ VL - 27 IS - 1 SP - 1 EP - 6 SN - 01466615 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9N2N2Y55MH. Database Contributor: MEDLINE. Database Contributor ID: 2537873. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2537873. Author Affiliation: Biological Carcinogenesis Program, National Cancer Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Although hepatitis B virus (HBV) has been closely associated with the development of hepatocellular carcinoma (HCC), no serologic markers of HBV can be found in up to 11% of HCC patients in developing countries and up to 68% of HCC patients in industrialized countries. Despite the absence of HBV serologic markers in these HCC patients, HBV DNA sequences have been found to be integrated into HCC DNA in 13-100% of these patients, indicating a possible role of HBV in the etiology of their HCC. Although six patients with chronic non-A, non-B hepatitis virus infection who were followed have been documented to develop HCC, it is not known whether the non-A, non-B hepatitis viruses cause or contribute to the development of HCC in some HCC patients without HBV serologic markers. Ethanol, cigarette smoking, oral contraceptives, and aflatoxin also have been suggested as possible etiologies and should be studied further. Suggested etiologies that are not supported by the published data include alpha-1-antitrypsin deficiency and schistosomiasis UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2537873&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Arya, S K TI - Human and simian immunodeficiency retroviruses: activation and differential transactivation of gene expression JO - AIDS Research and Human Retroviruses PY - 1988/01/01/ VL - 4 IS - 3 SP - 175 EP - 186 SN - 08892229 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; NI40JAQ945. Database Contributor: MEDLINE. Database Contributor ID: 2840105. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2840105. Author Affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: New West African human immunodeficiency viruses (HIV-2s) and simian immunodeficiency virus (SIV) contain functional transactivator (tat) gene and tat response elements. Their long terminal repeats (LTR) and tat genes are more related among themselves than to HIV-1 LTR and tat gene. The viral gene expression of HIV-2 as well as SIV can be stimulated by T cell activators, such as mitogens and phorbol esters. HIV-2 and SIV display a much broader transactivation response specificity than does HIV-1. The LTR-directed gene expression of HIV-2/SIV is not only transactivated by their own tat gene and by HIV-1 tat gene but also by factors in human T cell leukemia/lymphoma virus type I (HTLV-I) and simian virus 40 (SV40) infected cells, involving HTLV-I tat gene and SV40 T antigens, respectively. HIV-1 LTR-directed gene expression is much less transactivated by HIV-2/SIV tat genes and by factors in HTLV-I- and SV40-infected cells. Immune activation and heterologous transactivation of the LTR-directed gene expression may be relevant to the latency of virus infection and progression toward the acquired immunodeficiency syndrome (AIDS) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2840105&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Yanagihara, R TI - Human T-cell lymphotropic virus type I infection and disease in the Pacific basin JO - Human Biology PY - 1992/01/01/ VL - 64 IS - 6 SP - 843 EP - 854 SN - 00187143 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1427742. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1427742. Author Affiliation: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Human T-cell lymphotropic virus type I (HTLV-I), the cause of adult T-cell leukemia/lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), is widespread in the Pacific basin. Modes of virus transmission include blood transfusion (and intravenous drug use), breast milk, and sexual intercourse. High prevalences of HTLV-I infection and disease occur among the inhabitants of southwestern Japan and among first- and second-generation (issei and nisei) Japanese-Americans in the Hawaiian Islands. Other Pacific populations with high prevalences of HTLV-I infection include several remote groups in West New Guinea, Papua New Guinea, the Solomon Islands, and Vanuatu, which have had no contact with Japanese or Africans. By contrast, Micronesian and Polynesian populations, even those with prolonged contact with Japanese, exhibit low prevalences or no evidence of HTLV-I infection. Low prevalences of infection are also found in Australia, except among some aboriginal populations. Changing patterns of HTLV-I infection and disease are no better exemplified than in Japan, where striking reductions in transfusion-acquired infection and subsequent development of HAM/TSP have followed the institution of nationwide screening of blood donors for HTLV-I infection. Furthermore, virus transmission from mother to infant by means of infected breast milk has been markedly curtailed in HTLV-I-hyperendemic regions in Japan by interrupting the practice of breast feeding by HTLV-I-infected mothers. The next frontier of HTLV-I research is in Melanesia, where highly divergent sequence variants of HTLV-I have been discovered UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1427742&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Wynn, T A TI - Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology JO - Microbes and Infection PY - 1999/01/01/ VL - 1 IS - 7 SP - 525 EP - 534 SN - 12864579 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 10603569. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10603569. Author Affiliation: The Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10603569&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Kaslow, D C TI - Immunogenicity of Plasmodium falciparum sexual stage antigens: implications for the design of a transmission blocking vaccine JO - Immunology Letters PY - 1990/01/01/ VL - 25 IS - 1-3 SP - 83 EP - 86 SN - 01652478 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1704352. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1704352. Author Affiliation: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Immunogenicity of sexual stage antigens and boosting of transmission blocking antibodies following a natural infection are two critical factors in the design of an effective, subunit vaccine to block the transmission of malaria from man to mosquito. Immunogenicity and boosting are both T cell-dependent. Antigens, such as the 230-kDa, the 48/45-kDa, and the 40/10-kDa, expressed early in the extracellular forms of the sexual stage of Plasmodium falciparum, have limited immunogenicity in humans and in mice. In contrast, Pfs25, expressed predominantly in zygotes and ookinetes, has widespread immunogenicity in mice. Pfs25 expressed by a recombinant vaccinia virus (vSIDK) is also widely immunogenic in mice, and induces transmission blocking antibodies following multiple inoculations with vSIDK. The implications of these immunogenicity data are discussed relative to the design of an effective transmission blocking vaccine UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1704352&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Levine, P H TI - Immunologic markers for Epstein-Barr virus in the control of nasopharyngeal carcinoma and Burkitt lymphoma JO - Cancer detection and prevention. Supplement: official publication of the International Society for Preventive Oncology, Inc PY - 1987/01/01/ VL - 1 SP - 217 EP - 223 SN - 10436995 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2826001. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2826001. Author Affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Immunologic assays have been instrumental in implicating the Epstein-Barr virus (EBV) as an etiologic factor in nasopharyngeal carcinoma (NPC) and Burkitt lymphoma (BL). In this report, the importance of a variety of specific assays to detect EBV in tumor biopsies and antibodies to EBV antigens in serum from patients with NPC and BL is reviewed. In both NPC and BL, the involvement of EBV appears to differ in various geographic locations. Therefore, it is necessary to be able to interpret the available immunologic laboratory tests to know if a specific patient has "EBV-associated" or "non-EBV-associated" cancer. Such information is not only relevant to etiologic studies in different populations but to identifying individuals at high risk for NPC and BL, to monitoring their response to therapy, and to determining the most appropriate forms of therapy UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2826001&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Jordan, W S., Jr TI - Impediments to the development of additional vaccines: vaccines against important diseases that will not be available in the next decade JO - Reviews of Infectious Diseases PY - 1989/01/01/ VL - 11 Su IS - 3 EP - 1495 SN - 01620886 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2669104. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2669104. Author Affiliation: National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: The availability of new biotechnologies has led to the prediction that new or improved vaccines can be developed for 27 diseases within the next decade. The reasons why such optimism cannot be extended to the availability of vaccines for many other infectious diseases are considered by reviewing the steps in vaccine development, from identification of the etiologic agent to construction of attenuated or inactivated vaccines. Impediments to development may exist or arise at any point in this pathway (e.g., multiplicity of serotypes, inability to cultivate the pathogen, multistage life cycles with multiple antigens, unpredictability of epidemics, inadequate knowledge of pathogenesis and immunity, fear of gene splicing, need for an adjuvant, and lack of profitability). Diseases for which vaccines are not likely to be available in the next decade include trachoma, onchocerciasis, pneumonia due to Legionella and to mycoplasmas, amebiasis and giardiasis, schistosomiasis, syphilis, chlamydial urethritis, trypanosomiasis, leishmaniasis, and filariasis, and non-A, non-B hepatitis UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2669104&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Haverkos, H W TI - Infectious diseases and drug abuse. Prevention and treatment in the drug abuse treatment system JO - Journal of Substance Abuse Treatment PY - 1991/01/01/ VL - 8 IS - 4 SP - 269 EP - 275 SN - 07405472 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1787552. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1787552. Author Affiliation: Division of Clinical Research, National Institute on Drug Abuse, United States Public Health Service, Rockville, Maryland 20857 1; AB - MEDLINE Abstract: Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epidemiology of those infections among drug abusers in the USA, presents rudimentary aspects of medical management of selected infectious diseases, and discusses the need to integrate infectious diseases, drug abuse treatment, and public health approaches if we are to reverse, or at least stabilize, the trends of those diseases UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1787552&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Quinn, T C TI - Interactions of the human immunodeficiency virus and tuberculosis and the implications for BCG vaccination JO - Reviews of Infectious Diseases PY - 1989/01/01/ VL - 11 Su IS - 2 EP - 17 SN - 01620886 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2652254. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2652254. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 1; AB - MEDLINE Abstract: AIDS has become a global epidemic, with greater than 100,000 cases officially reported in 140 countries and an estimated 5-10 million asymptomatic carriers of the human immunodeficiency virus (HIV), the etiologic agent of AIDS. With an increase in HIV infection in some developing countries, there has been a resurgence in tuberculosis, and concern has been raised about the indications, efficacy, and safety of bacille Calmette-Guérin (BCG) vaccination. Anecdotal reports of local reactions and disseminated disease have been described in HIV-infected children and adults. Ten HIV-infected infants, who received BCG vaccination within 2 months of birth, developed local lymphadenitis at 4-15 months. However, in one preliminary survey in Zaire, the rates of local lymphadenitis were equal in HIV-infected and HIV-uninfected children, and no dissemination has been observed to date. Until further information is known, BCG vaccinations should not be given to symptomatic HIV-infected individuals and should only be given to HIV-infected children who are asymptomatic and who reside in areas where tuberculosis is highly endemic and where the risk of tuberculosis may outweigh the potential complications of BCG immunization UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2652254&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Seidman, M M TI - Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative JO - Molecular and Cellular Biology PY - 1987/01/01/ VL - 7 IS - 10 SP - 3561 EP - 3565 SN - 02707306 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3683393. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3683393. Author Affiliation: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Intermolecular recombination in mammalian cells was studied by coinfecting African green monkey cells in culture with two shuttle vector plasmids, each carrying an incomplete but overlapping portion of the gene for neomycin resistance. The region of homology between the two plasmids was about 0.6 kilobases. Recombination between the homology regions could reconstruct the neomycin resistance gene, which was monitored by analysis of progeny plasmids in bacteria. The individual plasmids carried additional markers which, in combination with restriction analysis, allowed the determination of the frequency of formation of the heterodimeric plasmid which would be formed in a conservative recombination reaction between the homologous sequences. Reconstruction of the neomycin resistance gene was readily observed, but only 1 to 2% of the neomycin resistance plasmids had the structure of the conservative heterodimer. Treatment of the plasmids which enhanced the frequency of the neomycin resistance gene reconstruction reaction did not significantly increase the relative frequency of conservative product plasmids. The results support nonconservative models for recombination of these sequences UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3683393&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Cohen, L K TI - Leadership role of dental associations: oral health promotion JO - International Dental Journal PY - 1990/01/01/ VL - 40 IS - 1 SP - 48 EP - 53 SN - 00206539 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2407662. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2407662. Author Affiliation: Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: 'Promoting Oral Health: Guidelines for Dental Associations' is the product of Working Group 3 on Oral Health Promotion of the Commission on Oral Health, Research and Epidemiology of the FDI. This paper describes the guidelines document, its rationale and its potential utility. An organized planned sequence of activities, including policy formation and dissemination, planning group structure and function, information gathering, goal setting, strategic planning of objectives and interventions, implementation as well as monitoring and evaluation, are reviewed. Relevant to both industrialized and developing countries, these oral health promotion guidelines can be used to develop programmes to demonstrate the benefit of self-care and appropriate demand for dental services UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2407662&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Magrath, I T TI - Malignant non-Hodgkin's lymphomas in children JO - Hematology - Oncology Clinics of North America PY - 1987/01/01/ VL - 1 IS - 4 SP - 577 EP - 602 SN - 08898588 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3323174. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3323174. Author Affiliation: Pediatric Branch, National Cancer Institute, Bethesda, Maryland 1; AB - MEDLINE Abstract: The spectrum of non-Hodgkin's lymphomas (NHL) that occurs in children differs markedly from that in adults. This is probably a consequence of differences in the proportions of precursor and mature lymphoid cells in the immune systems of children and adults, and the greater emphasis on the development of an immunologic repertoire in the child. Childhood NHL can be classified into three main types based on histology, all of them diffuse: lymphoblastic, small noncleaved cell, and large cell. The majority of lymphoblastic lymphomas are of immature T cell (thymocyte) origin, although a few have a B cell precursor phenotype. All express the enzyme terminal transferase. Small noncleaved lymphomas express B cell characteristics, as do the majority do the majority of large cell lymphomas, although a small proportion of the latter express T cell characteristics. Very few are of true histiocytic origin. Little is known of the epidemiology of lymphoblastic and large cell lymphomas. However, using histology as a diagnostic criterion, both occur throughout the world and occur primarily, as do all childhood NHL, in the first two decades of life. There appear to be at least two types of small noncleaved cell lymphomas, both of which are associated with specific chromosomal translocations. An endemic form occurs at high frequency in equatorial Africa, and a sporadic form occurs at low frequency throughout the world. The endemic tumor is associated with the Epstein-Barr virus, it has a high incidence of jaw tumors, and has a breakpoint on chromosome 8 that is usually some distance upstream of the c-myc oncogene. The sporadic tumor is only occasionally associated with EBV, it often involves the bone marrow, particularly at relapse, and has a breakpoint on chromosome 8 that is usually very close to or within the c-myc oncogene. Childhood NHL is rarely truly localized, and treatment regimens are always based on chemotherapy. There is no evidence that radiation is beneficial when modern combination drug regimens are employed as the primary therapeutic modality. Prophylactic treatment to the central nervous system is recommended in nearly all patients, and intrathecal drugs, usually supplemented by some form of high-dose or intermediate-dose methotrexate, appear to represent adequate prophylaxis to the CNS. The most effective regimens result in cure in almost all patients who have limited overt disease, and in a high proportion (50 to 75 per cent) of patients w... UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3323174&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Brossi A TI - Mammalian Alkaloids: Conversions of Tetrahydroisoquinoline-1-carboxylic Acids Derived from Dopamine JO - Planta Medica PY - 1991/01/01/ VL - 57 IS - 7 SP - 100 EP - 193 SN - 00320943 N1 - Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-017369. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-017369. Author Affiliation: Natural products Section, Laboratory of structural Biology, NIDDK, National Institutes of Health, Bethesda. Maryland 20392, U.S.A. 9Arnold Brossi) 1; AB - ALNAP Abstract: Racemic and optically active mammalian 6,7-dihydroxy-l,2,3.4-tetrahydroisoquinoline-l-carb- oxylic acids derived from dopamine, and quinonemeth- ides obtained from them by oxidative decarboxylation at physiological pH 7-9, are methylated by S-adenosyl-L- methionine in the presence of catechol-O-methyl-trans- ferase in vitro exclusively at the OH-group at C- 7. It can, therefore, be stated that these acids are unlikely inter- mediates in the biosynthesis ofisoquinolines en route to morphine. Enantiospecific and regioselective O-methy- lations observed with (S)- and (R)-norcoclaurines, lead- ing in the (S)-series predominantly to compounds methylated at the hydroxy group at C-6, and in the (R)- series to isomers methylated at the hydroxy group at C- 7, respectively, are in full accord with similar reactions oc- curring in the plant biosynthesis of morphine. Since the same methylation pattern is ascertained in reactions catalyzed by mammalian enzymes, it is suggested that mammals might be capable of synthesizing morphine from the same isoquinoline precursors KW - USA KW - USA KW - acid KW - alkaloid KW - Alkaloids KW - biology KW - biosynthesis KW - compound KW - compounds KW - dopamine KW - enzyme KW - enzymes KW - health KW - in vitro KW - isomer KW - isomers KW - isoquinoline KW - laboratory KW - Lead KW - mammalian KW - Mammals KW - methionine KW - methylation KW - morphine KW - Natural Product KW - natural products KW - Obtained KW - PH KW - physiological KW - plant KW - Precursor KW - precursors KW - products KW - regioselective KW - USA UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=ALNAP-017369&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Magrath, I T TI - Management of high-grade lymphomas JO - Oncology PY - 1998/01/01/ VL - 12 IS - 10 Suppl 8 SP - 40 EP - 48 SN - 08909091 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9830632. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9830632. Author Affiliation: Lymphoma Biology Section, National Cancer Institute, Bethesda, Maryland, USA 1; AB - MEDLINE Abstract: High-grade non-Hodgkin's lymphomas generally refer to immunoblastic lymphoma, lymphoblastic lymphoma, and small-noncleaved-cell lymphoma, three histological subtypes that were associated with the worst prognosis at the time of categorization 16 years ago in the Working Formulation for Clinical Usage. Small-noncleaved-cell lymphoma was classified further into Burkitt's lymphoma and non-Burkitt's lymphoma. The treatment of high-grade lymphomas in adults remains somewhat unfavorable today. In children, however, survival rates of 80% to 90% are being achieved with intensive short duration protocols. In this article, the management of Burkitt, Burkitt-like, and lymphoblastic lymphomas is discussed as is the possibility of improved survival in adults using treatment strategies developed for pediatric patients UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9830632&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Berzofsky, J A TI - Mechanisms of immunodominance in T-cell recognition, with applications to vaccine design JO - Princess Takamatsu symposia PY - 1988/01/01/ VL - 19 SP - 161 EP - 177 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2479631. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2479631. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Immunodominant T-cell antigenic sites can so dominate a response that their presence leads to high responsiveness and their absence to low responsiveness. Therefore, it is important to locate such sites for vaccine development. Factors that lead to immunodominance include features extrinsic to the structure of the site itself, such as the major histocompatibility complex (MHC) molecules of the host and the types of fragments produced by processing of the protein antigen before the T cell sees it. They also include factors intrinsic to the structure of the T-cell site, that determine a repertoire of potential immunodominant sites from which the extrinsic factors select a subset that will be immunodominant in a given individual. We have focused on one of these intrinsic factors, helical amphipathicity, that we have found to be a common feature among both helper and cytotoxic T-cell antigenic sites, suggesting that the same physical principles apply to sites seen in association with class I and class II MHC molecules. We have used this feature to locate immunodominant epitopes on the circumsporozoite protein of the Plasmodium falciparum malaria parasite and the envelope protein of the AIDS virus. Both helper and cytotoxic T-cell epitopes were identified. At least in the case of the helper T-cell sites, it was striking that the same sites in both the malaria and AIDS proteins studied that were immunodominant in the mouse were also immunodominant in the human, an indication that the same principles apply across species, and that the animal model will be useful for identifying sites to be used in vaccines for humans. These sites have been coupled with neutralizing antibody sites to produce artificial constructs that can elicit antibodies. It is hoped that the rational design of more complex versions of these artificial constructs will produce vaccines that are more effective than the natural pathogen proteins used in subunit vaccines, since such pathogen protein antigens have been selected through evolution to evade the immune system, not to optimize immunogenicity UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2479631&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Berzofsky, J A TI - Mechanisms of T cell recognition with application to vaccine design JO - Molecular Immunology PY - 1991/01/01/ VL - 28 IS - 3 SP - 217 EP - 223 SN - 01615890 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1708102. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1708102. Author Affiliation: Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Both helper and cytotoxic T lymphocytes generally recognize protein antigens not in their intact form, as antibodies do, but on the surface of another cell, after "processing" by that cell to unfold or cleave the protein into fragments and after association of the processed antigen with major histocompatibility complex (MHC) molecules on that cell. This complex process leads to immunodominance of certain segments from the protein, which depends not only on structural features intrinsic to the antigenic segment itself, but also on antigen processing and on the structure of the MHC molecules of the responding individual. We have explored all three of these factors, including the enzymes involved in processing, the way peptides bind to MHC molecules, and structural features such as helical amphipathicity that seem to favour T cell recognition. We have used this information to locate and characterize antigenic sites of proteins of interest for vaccine development, including proteins from the malaria parasite and the AIDS virus, HIV. For HIV, we have identified both helper and cytotoxic T cell sites, coupled a helper site to a B cell site to produce a synthetic immunogen that elicits neutralizing antibodies, and studied the effect of viral sequence variation on cytotoxic T cell recognition and binding of the immunodominant peptide to MHC molecules. This information suggests strategies for the rational design of synthetic or recombinant vaccines UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1708102&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Hallock, Y.F. AU - Manfredi, K.P. AU - Dai, J.R. AU - Cardellina, J.H. II. AU - Gulakowski, R.J. AU - McMahon, J.B. AU - Schaffer, M. AU - Stahl, M. AU - Gulden, K.P. AU - Bringmann, G. TI - Michellamines D-F, new HIV inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupenis [Language: en] JO - Journal of Natural Products PY - 1997/07/01/ VL - 60 IS - 7 SP - 677 EP - 683 SN - 01633864 AV - Location: *US (DNAL 442.8 L77); Number: 9741396 N1 - Database Contributor: AGRIS. Database Contributor ID: US9741396. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9741396. Author Affiliation: Hallock, Y.F. : National Cancer Institute, Frederick, MD 1; KW - cameroon KW - drug plants KW - leaves KW - chemical composition KW - quinoline alkaloids KW - spectrometry KW - chemical structure KW - chemistry KW - antiviral agents KW - mankind KW - herpetoviridae KW - antiprotozoal agents KW - cameroun KW - plante medicinale KW - feuille KW - composition chimique KW - alcaloide quinolique KW - spectrometrie KW - structure chimique KW - chimie KW - antiviral KW - genre humain KW - antiprotozoaire KW - camerun KW - plantas medicinales KW - hojas KW - composicion quimica KW - alcaloides de la quinolina KW - espectrometria KW - estructura quimica KW - quimica KW - viricidas KW - genero humano KW - medicamentos contra protozoarios KW - spectral analysis KW - stereochemistry KW - human immunodeficiency virus UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US9741396&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Murphy, P M TI - The molecular biology of leukocyte chemoattractant receptors JO - Annual Review of Immunology PY - 1994/01/01/ VL - 12 SP - 593 EP - 633 SN - 07320582 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; EC Number: 3.6.1.-. Database Contributor: MEDLINE. Database Contributor ID: 8011292. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8011292. Author Affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Leukocytes migrate from the blood to sites of inflammation in response to locally produced chemoattractants that activate specific cell surface receptors. The primary structures of leukocyte receptors for N-formyl peptides, C5a, platelet-activating factor, and 8 of the 18 known human chemokines (interleukin-8 and related molecules) have been deduced from cloned cDNAs. All of these are seven-transmembrane-domain rhodopsin-like G protein-coupled receptors. Biochemical and molecular genetic analysis of the chemoattractant receptors indicates that the chemoattractants may have both broadly overlapping as well as specialized roles in the regulation of acute and chronic inflammation. Interestingly, the chemokine receptors have functional homologues in human cytomegalovirus and Herpesvirus saimiri. Moreover, the Duffy antigen, which mediates invasion of erythrocytes by Plasmodium vivax, a major cause of malaria, is also a chemokine binding protein. These surprising developments suggest that in addition to leukocyte-mediated inflammation, the chemokines may also be involved in erythrocyte function and, through molecular mimicry, in microbial pathogenesis UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8011292&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Wellems, T E TI - Molecular genetics of drug resistance in Plasmodium falciparum malaria JO - Parasitology Today PY - 1991/01/01/ VL - 7 IS - 5 SP - 110 EP - 112 SN - 01694758 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 15463460. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15463460. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 1; AB - MEDLINE Abstract: Resistance to dihydro folate reductase inhibitors and resistance to chloroquine have been mapped to single genetic loci in Plasmodium falciparum. Specific point mutations in the dihydro folate reductase gene confer different degrees of resistance to two dihydro folate inhibitors, cycloguanil and pyrimethamine, depending on the positions of the mutations and the residues involved. The chloroquine resistance locus has been mapped to a 400 kilobase (kb) segment of chromosome 7 in a P. falciparum cross. Identification and characterization of genes within this segment should lead to an understanding of the rapid drug efflux mechanism responsible for chloroquine resistance UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=15463460&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Quinn, T C TI - Molecular variants of HIV-1 and their impact on vaccine development JO - International Journal of S T D & AIDS PY - 1998/01/01/ VL - 9 Su IS - 1 SP - 2 EP - 2 SN - 09564624 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 9874106. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9874106. Author Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA 1; AB - MEDLINE Abstract: The global HIV pandemic is heterogenous and dynamic, and comprised of many subepidemics in different geographic locations and populations, each with distinctive features such as risk factors for transmission, clinical presentation of disease, and viral subtypes in circulation. The genetic sequencing of HIV isolates has identified 2 major groups of HIV-1 designated group M (main) and group O (outlier). 10 different subtypes have been documented within the M group, subtypes A through J, comprising more than 95% of all HIV infections worldwide. Group O viruses have not been subtyped and are of limited distribution, found mainly in west Africa and with sporadic reports in Europe and the US. HIV-1 group M viruses have been the most intensely studied due to their global prevalence, with the best characterized subtype being subtype B, the predominant subtype in Europe and North America. The capacity of HIV subtypes to recombine allows rapid and marked genetic change. The greatest genetic variation in HIV-1 has been detected in central Africa, the area with the greatest density and duration of infection. Subtype C has the greatest frequency of any subtype globally, with epidemics in South Africa, East Africa, and India. The diverse molecular variation in the HIV genome among viral subtypes presents an obstacle to the development of an effective vaccine. The need to explore the development of both envelope-based and multi-gene-based vaccines is noted UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9874106&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Hayunga, E G TI - Morphological adaptations of intestinal helminths JO - Journal of Parasitology PY - 1991/01/01/ VL - 77 IS - 6 SP - 865 EP - 873 SN - 00223395 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1779289. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1779289. Author Affiliation: Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Nematodes, trematodes, cestodes, and acanthocephalans each have become adapted in different ways to the microenvironment of the vertebrate intestine. Life in this specialized habitat affords parasites a reliable source of nutrients, a relatively homeostatic environment, and protection from predators but, in exchange for these advantages, presents the special challenges of exposure to digestive enzymes, normal peristalsis, and host immune response to infection. Logically, the surface of the parasite should be the first part of the organism to encounter such challenges, and, for this reason, any response or reaction by the parasite is expected to be manifested at the parasite-host interface. Morphological adaptations of intestinal helminths to their microenvironment include modification of the tegumental surface that affords protection and increases absorptive surface area, development of specialized attachment organs, and, in some cases, complete loss of their own internal digestive system. Representative examples of such adaptations by helminths are described and discussed in terms of the parasite's nutritional requirements, site selection, and host specificity, and the possibility is suggested that some helminths may have adapted in ways that exploit host defensive mechanisms for their own benefit UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1779289&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rigau-Pérez, J G TI - Mosquito caused death: the yellow fever epidemics in San Juan of Puerto Rico 1804-1805 T2 - Muerte por mosquito: la epidemia de fiebre amarilla en San Juan de Puerto Rico 1804-1805 JO - Asociacion Medica de Puerto Rico. Boletin PY - 1991/01/01/ VL - 83 IS - 2 SP - 58 EP - 60 SN - 00044849 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2043230. Database Subset: AFRICAN HEALTHLINE. Language: Spanish. Accession Number: 2043230. Author Affiliation: Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: At the end of the eighteenth and beginning of the nineteenth centuries, yellow fever epidemics occurred frequently in America and Europe, in the vicinity of the Mediterranean, Atlantic, and Caribbean coasts. There is only brief information available on the 1804-5 epidemic in San Juan, but it shows that mortality in the city was inordinate. Nevertheless, the minutes of the meetings of the Municipal Assembly in this period make no mention of the epidemic, and allude to it only in veiled fashion. In spite of the accumulation of individual tragedies (for example, it is likely that the two daughters of governor Ramón de Castro were among the victims), the documents show little evidence of community reaction to the epidemic, which apparently ceased in mid-1805 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2043230&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Nussenblatt, R B TI - The natural history of uveitis JO - International Ophthalmology PY - 1990/01/01/ VL - 14 IS - 5-6 SP - 303 EP - 308 SN - 01655701 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2249907. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2249907. Author Affiliation: National Eye Institute, National Institutes of Health, Bethesda, Maryland 1; AB - MEDLINE Abstract: Inflammatory diseases of the eye were known to the ancients, but only recently have the underlying mechanisms to this problem become better defined. During the middle portion of this century, most cases of uveitis thought to be caused by infectious agents, such as those responsible for syphilis and tuberculosis. Since then, it has become clear that endogenous mechanisms of immunomodulation play an important role in these disorders, which along with environmental and genetic factors make up an important triad. Animals studies have indicated the pivotal role of the T-cell in many of these disorders. The development of T-cell lines has helped to further delineate cell to cell interactions that occur during an ocular inflammatory event. The presence in the eye of uveitogenic antigens raises the strong possibility of autoimmune driven processes as well, similar to what is seen in the animal models. The better understanding of ocular inflammatory mechanisms has led to improved therapeutic strategies, including Sandimmune, and more recently Cyclosporine G, a related compound that may be less nephrotoxic. Newer therapeutic strategies will focus on even more novel modes of immunomodulation, probably without the use of medications UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2249907&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR AU - Mauger AB TI - Naturally Occurring Proline Analogues JO - Journal of Natural Products PY - 1996/01/01/ VL - 59 IS - 12 SP - 1205 EP - 1211 SN - 01633864 N1 - Note: E-mail: mauger@dtpax2.ncifcrf.gov. Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-021977. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-021977. Author Affiliation: Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program National Cancer Institute, Bethesda, Maryland 20892 (Anthony B. Mauger) 1; AB - ALNAP Abstract: Introduction: Two earlier reviews (in 1966 and 1977) were published on the subject of proline analogs, 1,2 including bothe natural and synthetic compounds. The present review is restricted to naturally occurring compounds based upon t he pyrrolidine-2-carboxylic acid structure, both as the free amino acids and embedded in larger structures, usually peptides (however, analogues incorporated by 'directed biosynthesis' are not covered) Unlike the earlier reviews, 1,2 the present compilation does not include the compounds with other ring sizes such as azetidine-2-carboxylic acid and pipecolic acid. N-Substituted derivatives of proline itself are not included, but those of proline analogs are. The compounds reviewed are discussed in terms of source, structure, and biological activity ( where relevant), but not synsins inhibit the polymerization of tubulin and depolymerize preformed microtubules. 10 KW - Senait KW - Senait KW - acid KW - activity KW - amino acid KW - Amino acids KW - Analogs KW - analogues KW - azetidine-2-carboxylic acid KW - biological KW - Biological activities KW - biological activity KW - cancer KW - chemistry KW - compound KW - compounds KW - Derivatives KW - drug KW - free amino acid KW - naturally occurring KW - Occurring KW - Peptide KW - Peptides KW - pipecolic acid KW - review KW - Reviews KW - Ring KW - structure KW - structures KW - synthesis KW - synthetic KW - synthetic compound KW - therapeutic KW - therapeutics KW - Tubulin UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=ALNAP-021977&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Harris, M I TI - Noninsulin-dependent diabetes mellitus in black and white Americans JO - Diabetes - Metabolism Reviews PY - 1990/01/01/ VL - 6 IS - 2 SP - 71 EP - 90 SN - 07424221 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2198151. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2198151. Author Affiliation: National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: This report presents an overview of the prevalence, characteristics, morbidity, mortality, and risk factors for noninsulin-dependent diabetes (NIDDM) in Blacks and Whites in the United States. Data are drawn primarily from national surveys, but the report also includes the few clinical studies that have differentiated the two races. NIDDM constitutes 90-95% of all diabetes in the United States and is more prevalent in Black Americans than in Whites. Diabetes prevalence increases with age for both races and reaches 26% among Blacks aged 65-74 years compared with 18% among Whites. Rates of diabetes among persons aged 20-74 years are 30% higher in White women, 70% higher in Black men, and 100% higher in Black women, compared with White men. Approximately half of diabetes is undiagnosed in both races. White and Black diabetics are similar with regard to age, duration of diabetes, and diabetes therapies, although Blacks of both sexes are more obese than their White counterparts. Rates of vision loss, amputations, and renal disease are 1.5-4 times higher in Blacks than in Whites, although prevalence of hypertension is about equal in the two races. Blacks and Whites see the same physician specialists for their diabetes, but Whites have approximately 40% more visits to office-based physicians each year. Diabetes-specific mortality has declined significantly in the past decade and may now be lower in Black than in White diabetics. Risk factors for diabetes, including age, sex, obesity, and family history of diabetes, all operate within both race groups and probably interact with each other. The effect of gender and family history on rates of diabetes is similar in Blacks and Whites. Blacks have higher rates of diabetes at each obesity level, indicating that obesity alone cannot explain the differential in prevalence between the races. Impaired glucose tolerance (IGT), a strong risk factor for development of diabetes, increases with age in all race/sex groups except for Black women older than 54 years in whom rates of IGT, decline, possibly because of conversion of IGT to diabetes UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2198151&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - GEN AU - Murthy, P AU - Jayakumar, P N AU - Sampat, S TI - Of insects and eggs: a case report JO - Journal of Neurology, Neurosurgery and Psychiatry PY - 1997/01/01/ VL - 63 IS - 4 SP - 522 EP - 523 PB - BMJ Publishing Group LTD: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom SN - 00223050 N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 789492. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Other. Publication Type: Short Communication. Accession Number: 789492. Author Affiliation: 1997-1997 Year - Bangalore, 560 029, India, National Institute of Mental Health, Department of Psychiatry 1; AB - HEALTHLIT Abstract:
A middle aged woman presented with delusions of infestation and multimodal hallucinations due to an underlying glioma of the corpus callosum. After surgery, the phenomena in question changed and finally disappeared. A recurrence of the tumour caused dementia.
KW - Medical Science KW - Health / Public health KW - Medical Science KW - Health / Public health KW - delusions KW - hallucinations KW - glioma KW - dementia UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=789492&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Krause, R M TI - The origin of plagues: old and new JO - Science PY - 1992/01/01/ VL - 257 IS - 5073 SP - 1073 EP - 1078 SN - 00368075 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; Molecular Sequence: GENBANK/M95929. Database Contributor: MEDLINE. Database Contributor ID: 1509258. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1509258. Author Affiliation: Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Viruses and bacteria emerge in new and old forms to cause disease epidemics. Some microorganisms recur when changing life-styles (including increased international travel) offer new opportunities; others arise from new genetic variations. These various epidemics connect the future with the past, offering lessons for guarding the health of generations to come--lessons learned from diseases such as tuberculosis, toxic shock syndrome, Lyme disease, streptococcal infection, influenza, and acquired immunodeficiency syndrome (AIDS). The public must be vigilant to the possibility of new epidemics, learn more about the biology and epidemiology of microbes, and strengthen systems of surveillance and detection UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1509258&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Malik, I A TI - Out-patient management of febrile neutropenia in indigent paediatric patients JO - Academy of Medicine, Singapore. Annals PY - 1997/01/01/ VL - 26 IS - 6 SP - 742 EP - 746 SN - 03044602 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; A4P49JAZ9H. Database Contributor: MEDLINE. Database Contributor ID: 9522971. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9522971. Author Affiliation: Department of Medical Oncology, National Cancer Institute, Clifton, Karachi, Pakistan 1; AB - MEDLINE Abstract: Affordability of costly in-patient medical care and accessibility to the few cancer centres are serious problems faced by cancer patients in developing countries. Febrile neutropenia in particular is a major problem because delay in institution of antibiotic therapy can be rapidly fatal. We conducted a prospective non-randomised trial to evaluate the efficacy of administration of oral ofloxacin by caregivers to paediatric cancer patients with fever and neutropenia. Patients receiving chemotherapy who resided for away and were unable to reach the oncology ward within 12 hours of onset of fever or were unable to afford the expensive in-patient care were eligible for inclusion in the study. Requirements for enrollment included an absolute neutrophil count of < or = 0.5 x 10(9)/L, a temperature of > or = 38 degrees C, and ability to take oral medications. Caregivers were instructed to immediately administer oral ofloxacin on recognition of fever and to maintain constant contact with the oncology staff. Eighty-five of the 91 episodes were evaluable. These were most patients with solid tumours or non-Hodgkin's lymphoma (79%). Duration of neutropenia and fever was short and majority had pyrexia of undetermined origin (84%). Seventy-seven (91%) of the febrile episodes responded to ofloxacin with resolution of fever and neutropenia and hospitalisation was never required. Eight (9%) patients required hospitalisation. Most of them had prolonged neutropenia. They all responded to parenteral antibiotic therapy. No toxicity was observed and the cost of therapy was negligible. Out-patient therapy with oral ofloxacin may be an alternative to hospitalisation for those paediatric patients who are unable to afford or do not have access to in-patient care UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9522971&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rodgers, G P TI - Overview of pathophysiology and rationale for treatment of sickle cell anemia JO - Seminars in Hematology PY - 1997/01/01/ VL - 34 IS - 3 Suppl 3 SP - 2 EP - 7 SN - 00371963 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9004-22-2; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 9317195. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9317195. Author Affiliation: Hematology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1822, USA 1; AB - MEDLINE Abstract: Sickle cell anemia occurs in individuals who are homozygous for a single nucleotide substitution in codon 6 of the beta-globin gene. This single mutation leads to the formation of abnormal hemoglobin, HbS (alpha2betas[s]2), which is much less soluble when deoxygenated than hemoglobin A (HbA) (alpha2beta2). This insolubility causes aggregates of HbS to form inside sickle erythrocytes as they traverse the circulation. With full deoxygenation, polymer becomes so extensive that the cells become sickled in shape. Yet, even with high oxygen saturation values, quantities of HbS polymer may be sufficient to alter the rheologic properties of sickle erythrocytes in the absence of morphologic changes, and cells can occlude end arterioles, leading to chronic hemolysis and microinfarction of diverse tissues. Ultimately, this process leads to vaso-occlusive crises and irreversible tissue damage. Nonetheless, the spectrum of disease severity even among patients with grossly equivalent hematologic indices suggests that many other factors-including genetic, cellular, physiologic, and psychosocial-play a substantial role in determining the course of this disorder. Of the genetic factors, the level of fetal hemoglobin in particular has been established to favorably modify the clinical manifestations of patients with sickle cell disease and related conditions. Recent advances in the understanding of the molecular and cellular pathophysiology of sickle cell disease, coupled with new insights into the developmental regulation of human globin gene expression, have provided the scientific impetus and clinical rationale to attempt to augment the postnatal production of fetal hemoglobin. Furthermore, contemporary understanding of the quantitative relationship between the extent of HbS polymerization within the red cells and the degree of red blood cell and/or organ pathology has now enabled investigators to predict to what extent this intracellular pathogenic process must be inhibited to achieve clinically significant amelioration of disease manifestation. These areas will be covered in this overview. This is a US government work. There are no restrictions on its use UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9317195&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Kapikian, A Z TI - Overview of viral gastroenteritis JO - Archives of Virology. Supplementum PY - 1996/01/01/ VL - 12 SP - 7 EP - 19 SN - 09391983 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9015097. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9015097. Author Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 1; AB - MEDLINE Abstract: Diarrheal illnesses in humans have been recognized since antiquity. Such illnesses continue to take a great toll of lives, with a disproportionately high mortality in infants and young children in developing countries. Bacteriologic and parasitologic advances made during the past century led to the discovery of the etiology of some of the diarrheal illnesses, but the etiology of the major portion remained unknown. It was assumed that viruses caused most of these illnesses because: (i) bacteria were recovered from only a small proportion of episodes, and (ii) bacteria-free filtrates were found to induce gastroenteritis in adult volunteer studies. However, an etiologic agent could not be recovered despite the "golden age" of virology in the 1950's and 1960's when tissue culture technology enabled the discovery of numerous cultivatable enteric viruses, none of which emerged as an important etiologic agent of gastroenteritis. The discoveries of the Norwalk virus in 1972, and of rotaviruses in 1973, both without the benefit of in vitro tissue culture systems, ushered in a new era in the study of the etiology of viral gastroenteritis. The Norwalk virus was found to be an important cause of non-bacterial epidemic gastroenteritis in adults and older children, and rotaviruses were shown to be the single most important etiologic agents of severe diarrheal illnesses of infants and young children in both developed and developing countries. With the major advances in the study of rotaviruses, there is a high degree of optimism that in the not-too-distant future, a rotavirus vaccine will be available. In addition, the recent molecular biologic advances in the study of the Norwalk and Norwalk-like viruses, now firmly established as caliviviruses, represent a major new horizon in the study of these viruses UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9015097&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Georgiev, V S TI - Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis JO - Current Pharmaceutical Design PY - 1999/01/01/ VL - 5 IS - 7 SP - 545 EP - 554 SN - 13816128 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 81G6I5V05I; F4216019LN. Database Contributor: MEDLINE. Database Contributor ID: 10438896. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10438896. Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: Necator americanus is a nematode hookworm of the family Ancylostomatidae, subfamily Necatorinae. This nematode parasite, which is distinguished by two chitinous cutting plates in the buccal cavity and fused male copulatory spicules, is the causative agent of necatoriasis, a hookworm disease prevalent in the Americas as well as in the tropical regions of Africa, southern Asia, and Polynesia. The adult parasites attached to the villi of the small intestines will suck blood causing abdominal discomfort, diarrhea and cramps, anorexia, wight loss, and in advanced disease, hypochromic microcytic anemia. Hookworm infections in man, especially in children, are one of the leading causes of iron-deficiency anemia resulting directly from intestinal capillary blood loss following the feeding activities of fourth-stage (L4) larva and adult worms. Another clinical manifestation often associated with hookworm infections is cutaneous larva migrans (CLM). It is a well recognized, usually self-limiting condition caused by the infectious larvae of nematodes. CLM is characterized by skin eruption and represents a clinical description rather than a definitive diagnosis. Of the hookworm parasites, the dog and cat worm Ancylostoma braziliense is the most common causing CLM, although many other species have been implicated. The major subject of this review article will be discussion of the evolution of therapies and treatment of human necatoriasis and the development of experimental infections with N. americanus. Difference in the clinical efficacies of mebendazole and albendazole will be discussed along with drug resistance of N. americanus UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10438896&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Magrath, I TI - The pathogenesis of Burkitt's lymphoma JO - Advances in Cancer Research PY - 1990/01/01/ VL - 55 SP - 133 EP - 270 SN - 0065230X N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2166998. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2166998. Author Affiliation: Lymphoma Biology Section, National Cancer Institute, Bethesda, Maryland 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2166998&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Israel, M A TI - Pediatric oncology: model tumors of unparalleled import JO - National Cancer Institute. Journal PY - 1989/01/01/ VL - 81 IS - 6 SP - 404 EP - 408 SN - 00278874 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 2645407. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2645407. Author Affiliation: Molecular Genetics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Molecular studies of tumors arising during childhood have provided insights important for our understanding of the genetic and cellular events that now seem likely to mediate the development of many different malignancies. Of particular interest have been recent studies using recombinant DNA technology to study the pressure genetic alterations now thought to be central features of oncogenesis. Oncogenes and recessive cancer genes, first recognized to be of clinical importance during the study of Burkitt's lymphoma and retinoblastoma, are now thought to play a role in the development of most, if not all, tumors. Studies to identify more effective approaches to cancer prevention, detection, staging, and treatment are now seeking to build upon an understanding of those genetic alterations. It can be expected that pediatric oncology will once again play a pivotal role as these studies mature into clinical trials UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2645407&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Mulatu, M S TI - Perceptions of Mental and Physical Illnesses in North-western Ethiopia: Causes, Treatments, and Attitudes JO - Journal of Health Psychology PY - 1999/01/01/ VL - 4 IS - 4 SP - 531 EP - 549 SN - 13591053 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 22021645. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 22021645. Author Affiliation: National Institute of Mental Health, Bethesda, Maryland, USA 1; AB - MEDLINE Abstract: Four hundred and fifty adults (mean age 34 years; 55 percent males) from northwestern Ethiopia were interviewed to explore their causal beliefs about, perceived importance of various treatments for, and attitudes towards, six mental and three physical illnesses. Principal components analysis identified four meaningful illness causal belief dimensions: Psychosocial Stressors, Supernatural Retribution, Biomedical Defects, and Socio-Environmental Deprivation. Psychosocial Stressors and Supernatural Retribution were rated more important causes of mental than physical illnesses. Prayer and home/family care were suggested more strongly for treating mental than physical illnesses. Systematic associations were found between causal beliefs, treatment beliefs, and attitudes towards patients. Respondents' educational level was negatively related with traditional beliefs and positively related with favorable attitudes towards patients. It is concluded that causal beliefs, perceived importance of treatments, and attitude towards patients among northwestern Ethiopians are meaningfully interrelated. Implications for health services and research are discussed UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=22021645&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rodgers, G P TI - Pharmacological therapy JO - Bailliere's Clinical Haematology PY - 1998/01/01/ VL - 11 IS - 1 SP - 239 EP - 255 SN - 09503536 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 10872480. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10872480. Author Affiliation: Molecular and Clinical Hematology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1822, USA 1; AB - MEDLINE Abstract: Collectively sickle cell disease and beta-thalassaemia are the most commonly inherited single-gene defects world-wide and were the first group of diseases for which DNA-based detection strategies were utilized. Although genotypically distinct, these two groups of diseases exhibit several common clinical features: moderate-to-severe haemolytic anaemia, acute and progressive tissue damage, disease- or treatment-related organ failure and premature death. Within the last two decades, a striking improvement in life expectancy in the two patient populations has been observed, by dint of primary and secondary prevention strategies. However, apart from bone marrow transplantation, a generally applicable, specific and non-toxic form of treatment remains unavailable for these disorders. Nonetheless, a greater appreciation of the developmental control of human globin gene expression coupled with observations of the effects of certain classes of agents to 'reverse' erythroid cellular phenotype in in vitro and animal models have led to pharmacological trials to obtain meaningful increases in haemoglobin F production in patients affected by these two severe beta-globin disorders. Contemporary understanding of the quantitative relationship between the abnormal molecules in the red cells (aggregates of sickle haemoglobin) in the sickle cell syndromes and aggregated alpha-globin polypeptides in the beta-thalassemia syndromes, and the extent of the red cell and/or organ involvement, has now enabled investigators to predict how much inhibition of these intracellular pathogenic processes might be necessary to achieve partial or total abrogation of disease manifestations. The results of the Multicenter Study of Hydroxyurea and other controlled trials now bear out these predictions UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10872480&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Shahabuddin, M TI - Plasmodium ookinete development in the mosquito midgut: a case of reciprocal manipulation JO - Parasitology PY - 1998/01/01/ VL - 116 Su SP - S83 EP - S93 SN - 00311820 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9695113. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9695113. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA 1; AB - MEDLINE Abstract: The ookinete is one of the most important stages of Plasmodium development in the mosquito. It is morphologically and biochemically distinct from the earlier sexual stages--gametocytes and zygote, and from the later stages--oocyst and sporozoites. Development to ookinete allows the parasite to escape from the tightly packed blood bolus, to cross the sturdy peritrophic matrix (PM), to be protected from the digestive environment of the midgut lumen, and to invade the gut epithelium. The success of each of these activities may depend on the degree of the biochemical and physical barriers in the mosquito (such as density of blood bolus, thickness of peritrophic matrix, proteolytic activities in the gut lumen etc.) and the ability of the ookinete to overcome these barriers. Ookinete motility, secretion of chitinase, resistance to the digestive enzymes, and recognition/invasion of the midgut epithelium all may play crucial roles in the transformation to oocyst. The overall sporogonic development of Plasmodium, therefore, depends on the results of the two-way manipulations between the parasite and the vector mosquito. Study of ookinete development and of the cellular and biochemical complexities of the mosquito gut may therefore lead to the design of novel strategies to block the transmission of malaria. This article reviews the intricate interactions between the parasite and the mosquito midgut in the context of development and transmission of Plasmodium parasites UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9695113&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Brining, S K TI - Predicting the in vitro toxicity of synthetic beta-amyloid [1-40] JO - Neurobiology of Aging PY - 1997/01/01/ VL - 18 IS - 6 SP - 581 EP - 589 SN - 01974580 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 3U05FHG59S; E-mail: skb@helix.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9461056. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9461056. Author Affiliation: The National Institutes of Health, The National Institute on Aging, Bethesda, MD 20892-1582, USA 1; AB - MEDLINE Abstract: The in vitro toxicity of synthetic beta-amyloid (betaA4) is variable and unpredictable, limiting its use as a research tool. This study describes a method using Congo red (CR) to predict the in vitro toxicity of betaA4 solutions. Histopathologically, CR is used to stain the neuritic, betaA4-containing plaques, one of the hallmarks of Alzheimer's disease. In this study, synthetic betaA4 solutions were incubated with CR at a molar ratio of 1.0:2.5. The solutions were centrifuged and the absorbance of the supernatants were measured. Predictions of nontoxicity correlated with absorbance readings near zero. Toxicity was evaluated relative to control cells (vehicle only), using a hemocytometer to count PC-12 cells that excluded trypan blue. The positive predictive value of the test was 78% and the negative predictive value was 100%. To use this test, the toxic concentration(s) of betaA4 must first be established empirically. Then, the CR test can be used to evaluate the potential toxicity of betaA4 solutions at similar concentrations. Thus, this test can be used under a variety of laboratory circumstances UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9461056&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Puribhat, S TI - Present status of cancer treatment in several Asian countries JO - Gan To Kagaku Ryoho PY - 1992/01/01/ VL - 19 IS - 8 Suppl SP - 1153 EP - 1159 SN - 03850684 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1514828. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1514828. Author Affiliation: National Cancer Institute, Phayathai Bangkok, Thailand 1; AB - MEDLINE Abstract: Most of Asian Countries are still developing. Hence there are constraints in cancer treatment. There are those countries with fully equipped and fully distributed like western world such as Japan, Korea and Singapore. Other with some comprehensive cancer centers but confine to only big cities with poor coverage of the population resulting in a lot of late cases of cancer patients seen. Such countries are Bangladesh, China, India, Indonesia, Malaysia, Sri-Lanka, Thailand and etc. Still a lot of countries have no facilities to cope with cancer patients such as Brunei, Kampuchea, Laos, Nepal, Vietnam and etc. International collaboration and supports are needed UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1514828&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Contacos, P G TI - Primate malarias: man and monkeys JO - Journal of Wildlife Diseases PY - 1970/01/01/ VL - 6 IS - 4 SP - 323 EP - 328 SN - 00903558 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 16512134. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 16512134. Author Affiliation: Section on Primate Malaria Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health, Chamblee, Georgia 30341, USA 1; AB - MEDLINE Abstract: The question whether malarias of animals could be considered true zoonoses was examined. The research in this connection for the past decade or so was reviewed. That simian malarias are true zoonoses has been adequately demonstrated. In addition, there is great potential for human malarias being true anthroponoses. The author considers, therefore, that the significance of non-human reservoirs of human malaria in the control or eradication of malaria should be reconsidered UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=16512134&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Goedert, J J TI - Prognostic markers for AIDS JO - Annals of Epidemiology PY - 1990/01/01/ VL - 1 IS - 2 SP - 129 EP - 139 SN - 10472797 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 1669494. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1669494. Author Affiliation: Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Human immunodeficiency virus (HIV) infection causes a number of clinical syndromes and many laboratory abnormalities, often heralding the development of the life-threatening opportunistic infections or malignancies that are known as the acquired immunodeficiency syndrome (AIDS). Drawing heavily on the results of prospective cohort studies, particularly those that my colleagues at the National Cancer Institute and I have conducted, this paper reviews the relationship of AIDS to clinical signs and symptoms, immunologic measures, and viral assays. The risk of AIDS in the next 3 years is at least 25 to 50% for HIV-infected subjects who have oral candidiasis, unexplained fever, unexplained weight loss, a CD4+ lymphocyte count below 200 cells/microliter, or combinations of these. Elevated serum levels of beta 2 microglobulin and neopterin also appear to be strong predictive markers of AIDS, but further work is needed in diverse HIV-infected populations, such as intravenous drug users and persons in pattern II countries, such as Haiti and central Africa. Elevated levels of interferon or HIV-p24 antigen in the serum are insensitive but highly specific AIDS markers that may have predictive value independent of CD4 lymphocyte levels. Several potentially valuable immunologic (immunoglobulin levels, tumor necrosis factor, soluble interleukin 2) and virologic (HIV viremia) assays remain to be thoroughly evaluated or technically simplified. Data from prospective cohort studies have provided clinical and laboratory markers of AIDS risk that have proved essential for therapeutic trials and other clinical decisions. As effective treatments for HIV infection and its complications begin to emerge, these marker data will also prove invaluable for mathematic modeling of the scope, course, and public health response to the epidemic UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1669494&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Blaese, R M TI - Progress toward gene therapy JO - Clinical Immunology and Immunopathology PY - 1991/01/01/ VL - 61 IS - 2 Pt 2 SP - S47 EP - S55 SN - 00901229 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; EC Number: 3.5.4.4. Database Contributor: MEDLINE. Database Contributor ID: 1934613. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1934613. Author Affiliation: Cellular Immunology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: The prospect of treating human disease at its most fundamental (i.e., genetic) level has been the dream of clinicians for decades. There are over 4000 distinct genetic diseases, many of which are debilitating or fatal and most of which are incurable by standard medical approaches. Initial research was directed toward gene replacement treatment of genetic diseases involving the bone marrow, such as sickle cell anemia. Efficient methods for gene transfer were developed, but as this research progressed it became apparent that the biology of the bone marrow stem cell and the regulation of hemoglobin synthesis were not understood well enough to realistically permit an attempt at gene therapy for these diseases. These difficulties spurred research on alternative approaches which has unexpectedly led to the development of techniques to use gene therapy for the treatment of both rare genetic disorders as well as more common "nongenetic" diseases such as cancer. Our research has focused on one of the most promising cellular alternatives to the bone marrow stem cell, the T lymphocyte. This paper summarizes the historical background and evolution of thinking which led to the initial clinical applications of gene transfer and gene therapy in man UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1934613&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Nutman, T B TI - Protective immunity in lymphatic filariasis JO - Experimental Parasitology PY - 1989/01/01/ VL - 68 IS - 2 SP - 248 EP - 252 SN - 00144894 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2647512. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2647512. Author Affiliation: Clinical Parasitology Section, National Institutes of Health, Bethesda, Maryland 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2647512&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Sriram, T G TI - Psychotherapy in developing countries: a public health perspective JO - Indian Journal of Psychiatry PY - 1990/01/01/ VL - 32 IS - 2 SP - 138 EP - 144 SN - 00195545 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 21927442. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 21927442. Author Affiliation: Lecturer in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029 1; AB - MEDLINE Abstract: Psychotherapy is being increasingly recognised as an important treatment modality for various mental health problems. However, minimal efforts have been made to examine the utility of psychotherapy from the public health perspective, especially for developing countries. This paper outlines the present situation in developing countries with respect to the magnitude of mental health and related problems requiring psychotherapeutic help, the existing health and mental health facilities, the current training in psychiatry and psychotherapy in different training programmes, and the current state of mental health knowledge and skills of primary care personnel. A number of strategies for public health action are delineated to enhance the availability of this form of treatment to the large number of people requiring psychotherapeutic help. The needs for systematic research in this area are highlighted UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=21927442&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Lodmell, D L TI - Rabies DNA vaccines for protection and therapeutic treatment JO - Expert opinion on investigational drugs PY - 1999/01/01/ VL - 8 IS - 2 SP - 115 EP - 122 SN - 17447658 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: Dlodmell@atlas.niaid.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 15992067. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15992067. Author Affiliation: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA 1; AB - MEDLINE Abstract: Rabies is a successful zoonotic disease that has persisted over time, achieving worldwide distribution in a variety of species. Annually, in developing countries with limited access to high-quality antirabies biologics, approximately 50,000 individuals and millions of animals die of rabies. Many of these countries continue to use vaccines produced in sheep, goat or suckling mouse brain, with ultraviolet light or phenol inactivation of the virus. Although there are several efficacious rabies vaccines derived from cultured cells, such as the human diploid cell vaccine, they are costly to produce and prohibitively expensive for developing countries. DNA vaccines offer a new and powerful approach for the generation of needed vaccines. They are stable, inexpensive to produce, easy to construct and induce a full spectrum of long-lasting humoral and cellular immune responses. This review concerns the present state of rabies DNA vaccines, and addresses the technology that may enhance their therapeutic efficacy UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=15992067&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Harris, M I TI - Racial and ethnic differences in health insurance coverage for adults with diabetes JO - Diabetes Care PY - 1999/01/01/ VL - 22 IS - 10 SP - 1679 EP - 1682 SN - 01495992 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: harrism@ep.niddk.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 10526734. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10526734. Author Affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: OBJECTIVE: To evaluate the extent and types of health insurance coverage in a representative sample of adults with diabetes in the U.S. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans aged > or = 20 years. Information on medical history and treatment of diabetes was obtained to determine subjects who had been diagnosed with diabetes by a physician before the survey (n = 1,503) and subjects without diagnosed diabetes (n = 17,319). Information on health insurance coverage was obtained via a structured questionnaire for 96% of participants. RESULTS: A total of 93% of all adults with diabetes had some form of health insurance. Of these subjects, 73% had private insurance, 48% had Medicare coverage, 15% had Medicaid coverage, and 5% had Champus/Veterans Affairs coverage. Approximately 52% of adults with diabetes had multiple types of health insurance, and 54% had health care coverage through one or more government-sponsored programs. A greater proportion of non-Hispanic whites (91%) and non-Hispanic blacks (89%) than Mexican-Americans (66%) had health insurance among subjects aged 20-64 years. For those aged > or = 65 years, coverage was virtually 100% for all racial and ethnic groups. Non-Hispanic whites had the highest rate of coverage through private insurance (81%), with non-Hispanic blacks having an intermediate rate (56%) and Mexican-Americans having the lowest rate (45%). Rates of coverage were similar for adults with and without diabetes in each racial and ethnic group for any type of insurance and for private insurance. CONCLUSIONS: There are marked racial and ethnic differences in health insurance coverage for adults with diabetes, although these differences are similar to those for adults without diabetes. Whether these racial and ethnic disparities influence access to care, quality of care, or health outcomes for people with diabetes remains to be determined UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10526734&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rodgers, G P TI - Recent approaches to the treatment of sickle cell anemia JO - J A M A: The Journal of the American Medical Association PY - 1991/01/01/ VL - 265 IS - 16 SP - 2097 EP - 2101 SN - 00987484 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 1707463. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1707463. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1707463&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - O'Brien, S J TI - A role for molecular genetics in biological conservation JO - National Academy of Sciences of the United States of America. Proceedings PY - 1994/01/01/ VL - 91 IS - 13 SP - 5748 EP - 5755 SN - 00278424 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 7912434. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7912434. Author Affiliation: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201 1; AB - MEDLINE Abstract: The recognition of recent accelerated depletion of species as a consequence of human industrial development has spawned a wide interest in identifying threats to endangered species. In addition to ecological and demographic perils, it has become clear that small populations that narrowly survive demographic contraction may undergo close inbreeding, genetic drift, and loss of overall genomic variation due to allelic loss or reduction to homozygosity. I review here the consequences of such genetic depletion revealed by applying molecular population genetic analysis to four endangered mammals: African cheetah, lion, Florida panther, and humpback whale. The accumulated genetic results, combined with physiological, ecological, and ethological data, provide a multifaceted perspective of the process of species diminution. An emerging role of population genetics, phylogenetics, and phylogeography as indicators of a population's natural history and its future prognosis provides valuable data of use in the development of conservation management plans for endangered species UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7912434&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - James, S L TI - Role of nitric oxide in parasitic infections JO - Microbiological Reviews PY - 1995/01/01/ VL - 59 IS - 4 SP - 533 EP - 547 SN - 01460749 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 31C4KY9ESH. Database Contributor: MEDLINE. Database Contributor ID: 8531884. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8531884. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: Nitric oxide is produced by a number of different cell types in response to cytokine stimulation and thus has been found to play a role in immunologically mediated protection against a growing list of protozoan and helminth parasites in vitro and in animal models. The biochemical basis of its effects on the parasite targets appears to involve primarily inactivation of enzymes crucial to energy metabolism and growth, although it has other biologic activities as well. NO is produced not only by macrophages and macrophage-like cells commonly associated with the effector arm of cell-mediated immune reactivity but also by cells commonly considered to lie outside the immunologic network, such as hepatocytes and endothelial cells, which are intimately involved in the life cycle of a number of parasites. NO production is stimulated by gamma interferon in combination with tumor necrosis factor alpha or other secondary activation signals and is regulated by a number of cytokines (especially interleukin-4, interleukin-10, and transforming growth factor beta) and other mediators, as well as through its own inherent inhibitory activity. The potential for design of prevention and/or intervention approaches against parasitic infection (e.g., vaccination or combination chemo- and immunotherapy strategies) on the basis of induction of cell-mediated immunity and NO production appears to be great, but the possible pathogenic consequences of overproduction of NO must be taken into account. Moreover, more research on the role and regulation of NO in human parasitic infection is needed before its possible clinical relevance can be determined UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8531884&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Murthy, R S TI - Rural psychiatry in developing countries JO - Psychiatric Services PY - 1998/01/01/ VL - 49 IS - 7 SP - 967 EP - 969 SN - 10752730 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: rsm@nimhans.ren.nic.in. Database Contributor: MEDLINE. Database Contributor ID: 9661237. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9661237. Author Affiliation: National Institute of Mental Health and Neuro Sciences, India 1; AB - MEDLINE Abstract: During the last two decades several initiatives have been taken to improve psychiatric services in low-income rural areas in developing countries. They have included the formulation of national mental health programs and establishment of pilot programs for integration of mental health care with primary health care in India, Iran, and other countries in Asia, Africa, and South America. The psychiatrist has multiple roles to play in meeting the many challenges of providing mental health care in rural areas in developing countries UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9661237&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Cheever, A W TI - Schistosomiasis. Infection versus disease and hypersensitivity versus immunity JO - American Journal of Pathology PY - 1993/01/01/ VL - 142 IS - 3 SP - 699 EP - 702 SN - 00029440 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 8456933. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8456933. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8456933&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Mahmoud, H K TI - Schistosomiasis as a predisposing factor to veno-occlusive disease of the liver following allogeneic bone marrow transplantation JO - Bone Marrow Transplantation PY - 1996/01/01/ VL - 17 IS - 3 SP - 401 EP - 403 SN - 02683369 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8704694. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8704694. Author Affiliation: BMT Unit, National Cancer Institute, Cairo University, Egypt 1; AB - MEDLINE Abstract: Among 89 allogeneic bone marrow transplant recipients, veno-occlusive disease of the liver (VOD) was diagnosed in 10 patients (11.2%). All cases (n = 5) with schistosomal hepatic periportal fibrosis detected by pretransplant ultrasonography, developed severe fatal VOD in spite of normal initial liver functions and absence of portal hypertension. The incidence of VOD among patients without previous schistosomal contact was 5.95% (5/84). The relative risk to develop VOD was calculated to be 16.8-fold higher in patients with previous schistosomiasis. Schistosomal hepatic periportal fibrosis may thus be added to the known risk factors predisposing to the development of VOD in allogeneic transplant recipients UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8704694&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Caughey, B TI - Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues JO - Royal Society of London. Philosophical Transactions. Biological Sciences PY - 1994/01/01/ VL - 343 IS - 1306 SP - 399 EP - 404 SN - 09628436 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 3U05FHG59S; 64082-61-7; EC Number: 3.4.-. Database Contributor: MEDLINE. Database Contributor ID: 7913757. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7913757. Author Affiliation: Laboratory of Persistent Viral Diseases, NIH Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, Hamilton, Montana 59840 1; AB - MEDLINE Abstract: An abnormally protease-resistant and apparently neuropathogenic form of PrP accumulates in the brains of hosts with scrapie and related transmissible spongiform encephalopathies. Studies with scrapie-infected neuroblastoma cells have highlighted dramatic differences in the metabolism of the normal (protease-sensitive) and scrapie-associated (protease-resistant) isoforms of PrP. Furthermore, this model has been useful in identifying inhibitors of protease-resistant PrP accumulation and scrapie agent replication which are valuable as potential therapeutic agents and as probes of the mechanism of protease-resistant PrP formation. These inhibitors include the amyloid stain Congo red and certain sulphated glycans which are glycosaminoglycans themselves or glycosaminoglycan analogues. The relative potencies of various sulphated glycans correlate with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulphated polyanions is due to inhibition of protease-resistant PrP accumulation. These and other observations suggest that an interaction of PrP with endogenous sulphated glycosaminoglycans or proteoglycans is important in protease-resistant PrP accumulation, and raise the possibility that therapies for transmissible spongiform encephalopathies and other amyloidoses could be based on blocking (pre)amyloid-glycosaminoglycan interactions UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7913757&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Caughey, B TI - Scrapie associated PrP accumulation and its prevention: insights from cell culture JO - British Medical Bulletin PY - 1993/01/01/ VL - 49 IS - 4 SP - 860 EP - 872 SN - 00071420 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 8137133. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8137133. Author Affiliation: Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, Hamilton, Montana 59840 1; AB - MEDLINE Abstract: Transmissible spongiform encephalopathies (TSEs), Alzheimer's disease and other amyloidoses result in the accumulation of abnormally stable, potentially amyloidogenic proteins that appear to play central roles in disease pathogenesis. Scrapie-infected tissue culture cells have become well-developed models for studying how the TSE-specific protein, protease-resistant PrP, is made from its apparently normal precursor. The conversion of PrP to the protease-resistant state occurs on the plasma membrane or along an endocytic pathway to the lysosomes. The protease-resistant PrP has a much longer half-life than normal PrP and its accumulation in lysosomes may feature in TSE pathogenesis. Congo red and certain sulfated glycans potently inhibit protease-resistant PrP formation or stabilization in cell culture. These and other observations suggest that an interaction of PrP with glycosaminoglycans is critical in protease-resistant PrP accumulation and raises the possibility that therapeutic strategies for TSEs and other amyloidoses could be based on blocking (pre)amyloid-glycosaminoglycan interactions UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8137133&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Schechter, A N TI - Sickle cell disease expenditures and outcomes JO - Public Health Reports PY - 1997/01/01/ VL - 112 IS - 1 SP - 38 EP - 39 SN - 00333549 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: aschecht@helix.nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9018286. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9018286. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1822, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9018286&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Gaston, M H TI - Sickle cell disease: an overview JO - Seminars in Roentgenology PY - 1987/01/01/ VL - 22 IS - 3 SP - 150 EP - 159 SN - 0037198X N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3310245. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3310245. Author Affiliation: Sickle Cell Disease Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3310245&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rodgers, G P TI - Sickle-cell trait and physical training. Evidence for improved fitness JO - Archives of Internal Medicine PY - 1988/01/01/ VL - 148 IS - 5 SP - 1019 EP - 1020 SN - 00039926 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3365071. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3365071. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes and Diseases of the Kidney, National Institutes of Health, Bethesda, Md 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3365071&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Minton, A P TI - Solubility relationships in binary mixtures of hemoglobin variants Application to the "gelationrd of sickle-cell hemoglobin JO - Biophysical Chemistry PY - 1974/01/01/ VL - 1 IS - 5 SP - 387 EP - 395 SN - 03014622 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 23260428. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 23260428. Author Affiliation: Laboratory of Biophysical Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA 1; AB - MEDLINE Abstract: A thermodynamic treatment of solubility in binary mixtures of hemoglobin variants is presented. It is shown that the reported dependence of the minimum gelling concentration in five binary mixtures of the variants S, C(Harlem') Korle-Bu and A may be satisfactorily accounted for using the derived solubility relations together with simple models relating structure to interaction energies in the condensed phase.; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=23260428&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rodgers, G P TI - Spectrum of fetal hemoglobin responses in sickle cell patients treated with hydroxyurea: the National Institutes of Health experience JO - Seminars in Oncology PY - 1992/01/01/ VL - 19 IS - 3 Suppl 9 SP - 67 EP - 73 SN - 00937754 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 9034-63-3; X6Q56QN5QC. Database Contributor: MEDLINE. Database Contributor ID: 1379375. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1379375. Author Affiliation: Laboratory of Chemical Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: Hydroxyurea is one of several cytostatic agents that increase fetal hemoglobin (HbF) production in some patients with sickle-cell disease, although their mechanisms of action remain to be defined. We have studied the effects of hydroxyurea in several hospitalized patients with sickle-cell disease treated for 3 months, who were then maintained on outpatient therapy. Among hydroxyurea-treated patients, we found that about 75% respond with at least a twofold increase in the percentages of F reticulocytes and HbF. Among the responders, HbF levels increased twofold to 10-fold, with three patients achieving levels of 10% to 15%. Statistical analysis of the three cellular variables that determine HbF levels in patients with sickle-cell disease--namely, increased F-cell production, F-cell survival, and HbF/F cells--disclosed that HbF production, as measured by an increase in F reticulocytes, accounted for about 70% of the HbF elevation, with smaller contributions coming from augmentation of HbF/F cells and preferential survival of F cells. Four responders were re-treated with their optimal weekly hydroxyurea dose, given either in daily fractions or over 4 consecutive days, after a 1- to 3-month washout period. Greater HbF responses were attained with the optimal hydroxyurea dose than with the dose-regimen escalation, and usually occurred after a lag period. Furthermore, increases in HbF and F-cell levels were more rapid in patients receiving therapy on 4 out of 7 days rather than on a daily schedule. Our calculations show that the increases in HbF/F and F cells and the decrease in the fraction of dense cells during limited hydroxyurea administration should cause a significant improvement in intracellular sickle hemoglobin polymerization tendency. Controlled prospective trials are necessary to establish whether these effects lead to clinical benefit. Alternate schedules of hydroxyurea administration, or its use in conjunction with other means to elevate HbF or reduce mean cell hemoglobin concentration, may achieve greater inhibition of polymerization and thus be more likely to result in unequivocal amelioration of disease manifestations UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1379375&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Miller, L H TI - Strategies for malaria control: realities, magic, and science JO - New York Academy of Sciences. Annals PY - 1989/01/01/ VL - 569 SP - 118 EP - 126 SN - 00778923 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2698081. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2698081. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2698081&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Thom, T J TI - Stroke mortality trends. An international perspective JO - Annals of Epidemiology PY - 1993/01/01/ VL - 3 IS - 5 SP - 509 EP - 518 SN - 10472797 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7513238. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7513238. Author Affiliation: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1; AB - MEDLINE Abstract: This article presents death rates for cerebrovascular disease (stroke) by sex for ages 35 to 74 years in 1990 for 52 countries, and trends in rates from 1950 to 1990 for 30 countries. Rates are high in Asia and eastern Europe. In most industrialized countries, large declines occurred, particularly over the last 2 decades. The United States and Canada have low rates. Portugal, Trinidad, Paraguay, Mauritius, China, Korea, and most eastern European countries have the highest rates. Japan, with very high stroke mortality in the 1950s, experienced the largest absolute and percent decline and now ranks above western Europe and North America but below most other countries. In most industrialized countries, except in eastern Europe, stroke death rates declined more than 50% since 1970, somewhat more in women than in men. There is more uniformity in trends since 1970 than in earlier years. In several countries, either a downward slope accelerated in the 1970s, or a rising trend was reversed UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7513238&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Berzofsky, J A TI - Structural features of T-cell recognition: applications to vaccine design JO - Royal Society of London. Philosophical Transactions. Biological Sciences PY - 1989/01/01/ VL - 323 IS - 1217 SP - 535 EP - 544 SN - 09628436 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 2474171. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2474171. Author Affiliation: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: T lymphocytes, in contrast to antibodies, appear to recognize primarily a limited number of antigenic sites on any given antigenic protein. We find that a single site can so dominate the T-cell repertoire that the presence or absence of a response to one immunodominant site can make the difference between a high responder and a low responder, even though low responders respond to other sites almost as well as high responders. Besides interaction with major histocompatibility complex (MHC) molecules, the mode by which the antigen is processed into fragments for T-cell recognition also determines which sites are seen. The products of natural processing of the protein appear to be larger than the synthetic peptides and contain structures which hinder binding to certain MHC molecules or to the T-cell receptor. A third factor in immunodominance is the intrinsic structure of the antigenic site. We have shown that amphipathic helices have a higher than random chance of being immunodominant, and have developed a computer program to locate such structures in protein amino acid sequences. We prospectively predicted sites in the malaria circumsporozoite protein and found that the four most widely recognized sites in an endemic area of West Africa were all predicted. Similarly, we identified two helper T-cell sites from the HIV (AIDS virus) envelope, and have now shown that immunization with these elicits enhanced antibody responses to the whole envelope when injected into monkeys. These sites are also recognized by human T cells from volunteers who had been immunized with a recombinant vaccinia virus expressing the HIV envelope. Also, because cytotoxic T lymphocytes (CTLS) may play a critical role in defence against AIDS, we have used a recombinant vaccinia virus and transfectants expressing the HIV envelope gene to induce specific CTLS against the HIV envelope. Using synthetic peptides, we were able to identify the first CTL recognition site in the AIDS virus. These results may contribute to the rational design of vaccines UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=2474171&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Ugel, A R TI - Studies on isolated aggregating oligoribonucleoproteins of the epidermis with histochemical and morphological characteristics of keratohyalin JO - Journal of Cell Biology PY - 1971/01/01/ VL - 49 IS - 2 SP - 405 EP - 422 SN - 00219525 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 19866768. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 19866768. Author Affiliation: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 1; AB - MEDLINE Abstract: Histochemical and ultrastructural studies demonstrate that keratohyalin can be mobilized from fresh specimens of cattle hoof epidermis by 1.0 M potassium phosphate buffer (pH 7.0). Macroaggregates with histochemical characteristics identical to those of in situ keratohyalin granules (staining by Harris' hematoxylin, Congo red, diazotized sulfanilic acid, sodium alizarin sulfonate, toluidine blue, methyl green-pyronin, and acridine orange) and with similar morphological characteristics at the ultrastructural level are formed upon dialyzing the extracted keratohyalin against distilled water. Staining by basic dyes (toluidine blue, methyl green-pyronin, and acridine orange) is abolished by treating either in situ keratohyalin granules or isolated macroaggregates with ribonuclease. Electrophoresis of isolated macroaggregates on polyacrylamide gels in the presence of sodium decylsulfate results in the fractionation of a 13 member oligomeric series of ribonucleoproteins and two non-homologous species of ribonucleoproteins. The oligomeric series can be purified by isolating "stacked" oligomers on low concentration (3%) polyacrylamide gels. Fractionated oligomers on polyacrylamide gels and aggregates formed from purified ribonucleoproteins demonstrate histochemical characteristics identical to those of in situ keratohyalin granules. Aggregates formed from denatured ribonucleoproteins are highly disordered and are markedly different from in situ keratohyalin granules or nondenatured isolated macroaggregates at the ultrastructural level, possibly due to irreversible denaturation of the oligomers by sodium decylsulfate UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=19866768&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Brawley, O W TI - The study of untreated syphilis in the negro male JO - International Journal of Radiation: Oncology - Biology - Physics PY - 1998/01/01/ VL - 40 IS - 1 SP - 5 EP - 8 SN - 03603016 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 9422551. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9422551. Author Affiliation: Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892, USA 1; AB - MEDLINE Abstract: PURPOSE: The participation of minorities in clinical studies is the subject of much discussion and has even become the subject of Federal law. The project known as the Tuskegee Syphilis Study and officially titled "The Tuskegee Study of Untreated Syphilis in the Negro Male," is one of the great debacles of American medicine and a national shame. Despite the fact that its existence is well known, many do not know the historical facts of the study nor the context of the study. My purpose here is to recount the facts of the study and its historical context. METHODS: The history recounted here is taken from documents gathered during a U.S. Senate investigation of the study, original papers located in National Library of Medicine, and books about the trial. RESULTS: The trial began in 1931 as a survey of the natural history of untreated tertiary syphilis in Black men. This study enrolled 399 men with syphilis and 201 uninfected men to serve as controls. All were at least 25 years old at enrollment. The men were told they were in a study, but never educated about the implications. Later, men were not informed that there was a treatment for effective treatment for their disease--a treatment that was being withheld from them. This trial continued till 1972. CONCLUSION: Many of the issues that led to the study and caused it to continue for 40 years still exist. The lessons of the Public Health Study of Untreated Syphilis in the Untreated Negro include the dangers of paternalism, arrogance, blind loyalty, and misuse of science. "Those who do not appreciate history are condemned to repeat it" (Alfred North Whitehead) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9422551&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Rosner, J L TI - Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid JO - Antimicrobial Agents and Chemotherapy PY - 1993/01/01/ VL - 37 IS - 10 SP - 2251 EP - 2253 SN - 00664804 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; V83O1VOZ8L; EC Number: 1.-; 1.11.1.-; 1.11.1.15; 1.11.1.6; Genome Sequence: ahpC; ahpF; katG; oxyR. Database Contributor: MEDLINE. Database Contributor ID: 8257155. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8257155. Author Affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8257155&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Good, M F TI - T cells, T sites, and malaria immunity: further optimism for vaccine development JO - Journal of Immunology PY - 1988/01/01/ VL - 140 IS - 6 SP - 1715 EP - 1716 SN - 00221767 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 3279122. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3279122. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=3279122&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Kaslow, D C TI - Transmission-blocking immunity against malaria and other vector-borne diseases JO - Current Opinion in Immunology PY - 1993/01/01/ VL - 5 IS - 4 SP - 557 EP - 565 SN - 09527915 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 8216932. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8216932. Author Affiliation: Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1; AB - MEDLINE Abstract: Antibodies to sexual stage malaria parasites block transmission of Plasmodium by female mosquitoes. With the recent isolation of genes encoding several of the target antigens of transmission-blocking antibodies, the development of a subunit transmission-blocking vaccine against malaria is now a realistic goal UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8216932&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - St Georgiev, V TI - Treatment and developmental therapeutics of Mycobacterium tuberculosis infections JO - International Journal of Antimicrobial Agents PY - 1994/01/01/ VL - 4 IS - 3 SP - 157 EP - 173 SN - 09248579 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 18611607. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 18611607. Author Affiliation: National Institute of Allergy and Infectious Diseases, NIH, Solar Building, Room 4C-04, Bethesda, MD 20892, USA 1; AB - MEDLINE Abstract: Tuberculosis still remains a serious health problem in many regions of the world, especially in developing nations. With the spread of AIDS and the increase in the number of immunocompromised patients, the problem of tuberculosis has been greatly exacerbated because of the susceptibility of such patients to mycobacteria. Currently, chemotherapy using multiple drug regimens with isoniazid, rifampin, streptomycin, pyrazinamide, and ethambutol is the recommended treatment for tuberculosis. The presence of drug resistance is still a major concern and new generations of more effective antimycobacterial agents (antibiotics, fluoroquinolone derivatives) are the subject of active investigation. The search for novel strategies to cure tuberculosis led to studies exploring the role of cytokines in host defenses and the application of adoptive immunotherapy. New and improved methodology for in vitro and in vivo screening of antimycobacterial activity has also been reported UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=18611607&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - LeMasters, C Z TI - Treatment of pulmonary tuberculosis JO - Lippincott's Primary Care Practice PY - 1999/01/01/ VL - 3 IS - 1 SP - 55 EP - 58 SN - 10885471 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 10214202. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10214202. Author Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 1; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10214202&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Ginsberg, A M TI - The tuberculosis epidemic. Scientific challenges and opportunities JO - Public Health Reports PY - 1998/01/01/ VL - 113 IS - 2 SP - 128 EP - 136 SN - 00333549 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; E-mail: ag73i@nih.gov. Database Contributor: MEDLINE. Database Contributor ID: 9719813. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9719813. Author Affiliation: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA 1; AB - MEDLINE Abstract: One in every three people on Earth is believed to be infected with Mycobacterium tuberculosis, leading to seven to eight million cases of active tuberculosis (TB) per year and approximately three million deaths annually. this epidemic, like those of most infectious diseases, creates scientific challenges and opportunities as it raises the demand for public health solutions. The currently available weapons for fighting TB are inadequate. The ultimate goal of biomedical TB research is to lessen the public health burden of this disease by developing improved diagnostic, therapeutic, and intervention strategies. Achieving this goal requires a base of knowledge about the biology of M. tuberculosis and related mycobacteria, their interactions with human and animal hosts, and the nature of an effective host-protective immune response. TB researchers are applying this accumulating base of knowledge to developing rapid, easy-to-use diagnostic assays appropriate for low-as well as high-income countries, improving the current complicated therapeutic regimen, identifying potential new drugs to combat multidrug-resistant TB, and creating more effective vaccines UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=9719813&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Novakovic, B TI - U.S. childhood cancer survival, 1973-1987 JO - Medical and Pediatric Oncology PY - 1994/01/01/ VL - 23 IS - 6 SP - 480 EP - 486 SN - 00981532 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 7935174. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7935174. Author Affiliation: Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 1; AB - MEDLINE Abstract: The surveillance, epidemiology, and end-results (SEER) data on 5-year relative survival rates (1973-1987) for the most common pediatric tumors (ages 0-14) were analyzed. The SEER data are population based, so the observed progress in survival from childhood cancer represents the real impact that development in cancer treatment had on the population followed by the registry. The greatest increase in survival rate from 1973 until 1987 has been achieved in hematopoietic tumors such as acute lymphocytic leukemia (ALL), in which survival increased from 47.6% (1973-1977) to 60.8% (1983-1987), and Burkitt's lymphoma in which survival increased from 27.6% (1973-1977) to 68.7% (1983-1987). Solid tumors showed a less steep, but steady increase in survival rates. Flattening in the survival rates since 1978-1982 has been observed for acute leukemia, astrocytoma, medulloblastoma, and osteosarcoma. Females have better survival rates for most pediatric tumors, except Hodgkin's disease. Analysis of race of childhood leukemia confirmed that black children have worse survival than white. When solid tumors were analyzed by stage at presentation, there was no indication that diagnosis in earlier stages of disease accounted for the improved survival. Observed flattening in the survival rates since 1978-1982 of leukemia and some solid tumors warrants further follow-up UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7935174&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Gad-el-Mawla, N TI - Use of ifosfamide in the management of breast cancer JO - Annals of Oncology PY - 1992/01/01/ VL - 3 Su IS - 3 SP - 21 EP - 23 SN - 09237534 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: UM20QQM95Y. Database Contributor: MEDLINE. Database Contributor ID: 1390313. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1390313. Author Affiliation: National Cancer Institute, Fom-El-Khalig, Cairo, Egypt 1; AB - MEDLINE Abstract: Ifosfamide, a cytostatic drug highly active in vivo, has slight superiority over cyclophosphamide. It proved effective in experimental tumor systems including the C3H mammary carcinoma. Clinical studies of ifosfamide as monotherapy in breast cancer, begun in 1974 by Ahmann et al., reported a 20% objective response. Subsequent trials were conducted from 1974 through 1977 using ifosfamide as monotherapy, and ifosfamide was also combined with other chemotherapeutic agents. In 1975, Hartwich and coworkers used the combination ifosfamide/vincristine with a 25% overall response. With the introduction of the uroprotector mesna, more studies were instituted. In 1984, using the IMF combination (ifosfamide/methotrexate/5-fluorouracil), we reported a 25% overall response. Other groups also reported good results for ifosfamide-containing combinations, with overall responses ranging from 25% to 79%. Recently, Sanchiz and Milla used high-dose ifosfamide to treat metastatic breast cancer, with a 40% overall response. In conclusion, ifosfamide's efficacy in breast cancer has been confirmed and the drug is highly recommended in combination chemotherapy as a first-line treatment UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1390313&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - de The, G TI - Viruses and human cancers: challenges for preventive strategies JO - Environmental Health Perspectives PY - 1995/01/01/ VL - 103 Su IS - 8 SP - 269 EP - 273 SN - 00916765 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: dethe@pasteur.fr. Database Contributor: MEDLINE. Database Contributor ID: 8741797. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8741797. Author Affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland and Institut Pasteur, Unit of Epidemiology of Oncogenic Viruses, Paris, France 1; AB - MEDLINE Abstract: Virus-associated human cancers provide unique opportunities for preventive strategies. The role of human papilloma viruses (HPV 16 and 18), hepatitis B virus (HBV), Epstein-Barr herpes virus (EBV), and retroviruses (human immunodeficiency virus [HIV] and human T-cell leukemia/lymphoma virus [HTLV]) in the development of common carcinomas and lymphomas represents a major cancer threat, particularly among individuals residing in developing countries, which account for 80% of the world's population. Even though these viruses are not the sole etiological agents of these cancers (as would be the case for infectious diseases), different approaches can be implemented to significantly decrease the incidence of virus-associated malignancies. The first approach is vaccination, which is available for HBV and possibly soon for EBV. The long delay between primary viral infection and development of associated tumors as well as the cost involved with administering vaccinations detracts from the feasibility of such an approach within developing countries. The second approach is to increase efforts to detect pre-cancerous lesions or early tumors using immunovirological means. This would allow early diagnosis and better treatment. The third strategy is linked to the existence of disease susceptibility genes, and suggests that counseling be provided for individuals carrying these genes to encourage them to modify their lifestyles and other conditions associated with increased cancer risks (predictive oncology). Specific recommendations include: a) increase international studies that explore the causes of the large variations in prevalence of common cancers throughout the world; b) conduct interdisciplinary studies involving laboratory investigation and social sciences, which may suggest hypotheses that may then be tested experimentally; and c) promote more preventive and health enhancement strategies in addition to curative and replacement therapies UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=8741797&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Ottesen, E A TI - The Wellcome Trust Lecture. Infection and disease in lymphatic filariasis: an immunological perspective JO - Parasitology PY - 1992/01/01/ VL - 104 Su EP - 58 SN - 00311820 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1589302. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1589302. Author Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892 1; AB - MEDLINE Abstract: The basic tenet of the immunological perspective of filarial disease is that differential immune responsiveness among individuals exposed to infection results in the different clinical manifestations that develop. The mechanisms involved in this differential responsiveness appear to reflect different T-cell cytokine response patterns. Asymptomatic patients with the clinically silent presentation of 'asymptomatic microfilaraemia', who have been previously described as being 'immunosuppressed' with respect to their generating pro-inflammatory (Th1-type) immune responses to parasite antigen, are now recognized to be fully responsive to parasite antigen but to produce cytokines and mediators that have primarily anti-inflammatory (Th2-like) effects. Studies with immunodeficient mice have indicated the existence of two alternative pathways to the development of lymphatic pathology: one dependent on the induction of inflammatory reactions by the host immune response, the other entirely independent of the immune system and reflecting the direct actions of the parasite or its products on the lymphatics. As histopathology of affected human lymphatics is consistent with this hypothesis, it may be that the lymphatic pathology seen normally in the amicrofilaraemic, highly immunoresponsive infected patients derives from inflammation induced by immune responses to parasite antigen, whereas the lymphatic pathology sometimes seen coexisting with the 'immunosuppressed' state of asymptomatic microfilaraemia actually reflects lymphatic damage that is not immunologically mediated. Though little information exists about the 'natural history' of lymphatic filariasis, there is no evidence for an inevitable progression from one clinical form to another.(ABSTRACT TRUNCATED AT 250 WORDS) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1589302&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Schwan, T G TI - Xenopsylla bantorum is an east African subspecies of X. cheopis [Siphonaptera: Pulicidae] JO - Journal of Medical Entomology PY - 1992/01/01/ VL - 29 IS - 6 SP - 927 EP - 933 SN - 00222585 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1460630. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1460630. Author Affiliation: Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840 1; AB - MEDLINE Abstract: The geographic distribution, host association, and male genital morphology of Xenopsylla bantorum Jordan were examined and compared with the Nilotic and Oriental "strains" of Xenopsylla cheopis (Rothschild). The more acute shape of the ninth sternite separates X. bantorum from all types of X. cheopis; however, the length of the first process of the male's clasper and the number of setae on this process are significantly different among all three groups; the Nilotic strain of X. cheopis is intermediate to the others. Specimens collected from both wild and commensal rodents in Nakuru, Kenya, were all X. bantorum, suggesting that X. cheopis present early in the century that resulted from introductions on Rattus rattus had been absorbed by the native X. bantorum population. These factors and a review of opinions by others concerning the status of X. bantorum demonstrate that this flea is not specifically distinct from X. cheopis. The trinomial X. cheopis bantorum is erected. Furthermore, the Nilotic and Oriental "strains" of X. cheopis are distinguishable morphologically solely by the length of the male's first process UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1460630&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Srivastava, M TI - Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane JO - Journal of Biological Chemistry PY - 1995/01/01/ VL - 270 IS - 39 SP - 22714 EP - 22720 SN - 00219258 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 11130-51-1; Molecular Sequence: GENBANK/U29460; GENBANK/U29461; GENBANK/U29462; GENBANK/U29463; GENBANK/U29464; GENBANK/U29469. Database Contributor: MEDLINE. Database Contributor ID: 7559396. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 7559396. Author Affiliation: Laboratory of Cell Biology and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA 1; AB - MEDLINE Abstract: Cytochrome b561 is an electron transfer protein unique to neuroendocrine secretory vesicles. The Southern blot hybridization shows that it is a single copy gene highly conserved throughout phylogeny. The transcription unit spans approximately 11 kilobases, and heterologous transcription sites are located 404 bases 5' to the translation initiation codon. The sequence of the 5'-flanking region is GC-rich and lacks a typical TATA box at the usual position. However, it has a CAAT sequence at -132 and potential recognition sequences for several transcription factors including SP1, GR-PR-MMTV, AP4, gERE, JCV repeat, AP2, and NF-kappa B. Each of the five transmembrane segments are encoded by five consecutive exons. This corroborates the five-transmembrane model proposed for human, mouse, and Xenopus rather than six proposed for bovine. The cytochrome was found to be highly expressed in colon cancer cell lines, T cell lymphomas, and K-562 cell lines. However, in B-cell lymphomas such as Burkitt's and Daudi, the cytochrome b561 expression was completely shut down. The results in this report are the first to demonstrate the structural organization and regulatory sequences of the cytochrome b561 gene encoding an integral membrane protein of neuroendocrine storage vesicles of neurotransmitters and peptide hormones. Unexpected results on cytochrome b561 expression in cells of lymphocytic origin and its complex regulation in tumor cells provide new insights into cytochrome b561 gene regulation UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=7559396&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - AU - Desai, S A TI - A nutrient-permeable channel on the intraerythrocytic malaria parasite JO - Novartis Foundation Symposium PY - 1999/01/01/ VL - 226 SP - 89 SN - 15282511 N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; Contract Number: Z01 AI000882-07/AI/NIAID NIH HHS. Database Contributor: MEDLINE. Database Contributor ID: 10645540. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10645540. Author Affiliation: National Institutes of Health/National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, MD 20814, USA 1; AB - MEDLINE Abstract: The intraerythrocytic malaria parasite Plasmodium falciparum faces at least three membranous barriers to acquisition of nutrients from serum: the human erythrocyte membrane, the parasitophorous vacuole membrane (PVM) and the parasite plasma membrane. The PVM is a specialized parasite-derived membrane that separates the parasite from erythrocyte cytosol. I used the patch clamp method to identify and characterize the main transport pathway on the PVM. Gigaohm seals, formed on mature freed trophozoites, revealed a 140 pS channel permeable to both cations and anions on the PVM. This channel is present at high density, is open more than 95% of the time at the PVM resting potential, and is capable of transporting amino acids and monosaccharides across the PVM. This nutrient-permeable channel was then reconstituted into artificial lipid bilayers, where it exhibited similar slope conductances, gating, voltage dependence and permeability to soluble nutrients. In bilayers, the channel was found to have non-saturating kinetics and an effective pore diameter of 23 A. These experiments, together with the patch clamp findings, suggest a high capacity molecular sieve that allows the parasite to acquire soluble nutrients from erythrocyte cytosol UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10645540&site=ehost-live&scope=site DP - EBSCOhost DB - awn ER - TY - JOUR T1 - The National Filaria Control Program (NFCP) of India: investigative challenges. AU - BEYE, H. K. AU - WRIGHT, W. H. JO - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases JF - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases Y1 - 1959/// VL - 7 IS - 2 SP - 45 EP - 52 AD - BEYE, H. K.: U.S. Department of Health, Education & Welfare, Public Health Service, National Institutes of Health, Bethesda 14, Maryland, U.S.A. N1 - Accession Number: 19610801377. Publication Type: Journal Article. Language: not specified. N2 - Beye & Wright outline a variety of research projects that might be undertaken by the National Filaria Control Programme of India in its efforts to control, and ultimately eradicate, infections due to Wuchereria bancrofti and W. malayi. J. W. Smith. KW - control programmes KW - infections KW - India KW - Brugia malayi KW - Onchocercidae KW - Wuchereria KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Wuchereria KW - South Asia KW - Asia KW - Developing Countries KW - Commonwealth of Nations KW - control programs KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610801377&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - The prophylactic activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine(Hoechst S 688) in experimental schistosome infections. AU - LUTTERMOSER, G. W. AU - BRUCE, J. I. AU - MCMULLEN, D. B. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1959/// VL - 45 IS - 4, Sect. 2 SP - 54 EP - 55 SN - 0022-3395 AD - LUTTERMOSER, G. W.: National Institutes of Health, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610802749. Publication Type: Journal Article. Language: not specified. N2 - For abstract of full account of this work see No. 2750 below.]. KW - infections KW - prophylaxis KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802749&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - [English title not available] / Neuere Untersuchungen aus dem Gebiet der Parasitenphytiologie. AU - VON BRAND, T. JO - Zeitschrift fur Tropenmedizin und Parasitologie JF - Zeitschrift fur Tropenmedizin und Parasitologie Y1 - 1959/// VL - 10 IS - 2 SP - 123 EP - 134 AD - VON BRAND, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland, U.S.A. N1 - Accession Number: 19600802213. Publication Type: Journal Article. Language: not specified. N2 - Von Brand reviews recent work on the physiology of parasites. He also discusses the factors that have influenced the development of work in this field and the way the problems are approached. The value of work in which an over-all view of metabolism is sought is discussed in relation to studies in which one particular enzyme or group of enzymes is examined in detail. W. P. Rogers. KW - parasites KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19600802213&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Development in vitro of some parasitic nematodes of vertebrates. AU - WEINSTEIN, P. P. AU - JONES, M. F. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1959/// VL - 77 IS - 2 SP - 137 EP - 162 SN - 0077-8923 AD - WEINSTEIN, P. P.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610800260. Publication Type: Journal Article. Language: not specified. N2 - Weinstein & Jones describe some recent investigations on the growth and maintenance of nematode larvae in vitro. A basal medium of serum-chick embryo homogenate was used. In relatively high concentrations of these materials filariform larvae of Nippostrongylus muris were capable of reaching the fifth stage. Human serum was compared directly with rat serum and found to be superior. However, considerable variations in the yield of fifth-stage worms occurred with different samples of the same basal medium. Supplements such as a vitamin mixture, Eagles' medium and liver concentrate increased the fifth-stage worm yield. The worms did not mate in culture but infertile eggs were deposited by the females. In chemically defined media alone, or with supplements added, survival but no growth occurred. Under strict axenic conditions, development from egg to mature adult was obtained without the use of antibiotics. Worms which were removed from the intestine of the rat did not mate during in vitro culture. Third-stage larvae of Necator americanus showed some development when cultured by similar techniques. J. E. D. Keeling. KW - antibiotics KW - blood serum KW - culture media KW - embryos KW - in vitro KW - in vitro culture KW - larvae KW - liver KW - nematode larvae KW - supplements KW - survival KW - techniques KW - Ancylostomatidae KW - man KW - Necator KW - Necator americanus KW - Nematoda KW - Nippostrongylus KW - rats KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Ancylostomatidae KW - Necator KW - Heligmonellidae KW - Muridae KW - rodents KW - small mammals KW - chemically defined media KW - Secernentea KW - Strongylida KW - third stage larvae KW - Pesticides and Drugs (General) (HH400) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610800260&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - A comparison of the development of some rat and mouse helminths in germfree and conventional guinea pigs. AU - NEWTON, W. L. AU - WEINSTEIN, P. P. AU - JONES, M. F. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1959/// VL - 78 IS - 1 SP - 290 EP - 306 SN - 0077-8923 AD - NEWTON, W. L.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610800093. Publication Type: Journal Article. Language: not specified. N2 - guineapigs which had been delivered and maintained germ-free were compared with conventional guineapigs as hosts for a number of helminths normally parasitic in rats and mice. In conventional animals Nippostrongylus muris failed to develop but fourth-stage larvae and adults were recovered from two of six germ-free guineapigs which received similar infections. Germ-free animals proved more satisfactory hosts for Nematospiroides dubius than did conventional animals. It was demonstrated that the method of delivery and type of diet were not the underlying reason for this difference. Both species produced fertile eggs in germ-free animals. Hymenolepis nana developed successfully in both types of host. J. E. D. Keeling. KW - helminths KW - infections KW - methodology KW - small mammals KW - techniques KW - guineapigs KW - Heligmosomoides KW - Heligmosomoides polygyrus KW - Hymenolepididae KW - Hymenolepis KW - mice KW - Nippostrongylus KW - rats KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Heligmosomidae KW - Nematoda KW - invertebrates KW - Heligmosomoides KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - Hymenolepididae KW - Muridae KW - small mammals KW - Heligmonellidae KW - Cyclophyllidea KW - guinea pigs KW - methods KW - parasitic worms KW - Secernentea KW - Strongylida KW - Vampirolepis KW - Vampirolepis nana KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610800093&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Studies on chemotherapy of experimental schistosomiasis. V. Enhancement of the schistosomacidal activity of tartar emetic and stibophen by glycerin. AU - LUTTERMOSER, G. W. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1959/// VL - 45 IS - 3 SP - 301 EP - 309 SN - 0022-3395 AD - LUTTERMOSER, G. W.: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610802748. Publication Type: Journal Article. Language: not specified. Registry Number: 15489-16-4, 28300-74-5. N2 - Luttermoser has attempted to increase the schistosomicidal activity of tartar emetic and stibophen by the addition of one of several possible organic adjuvants; only glycerin, of 32 compounds tested, was successful. 50 mg. or 75 mg. of tartar emetic per kg. body-weight given orally twice a day for five days or 160 mg. of stibophen per kg. given intraperitoneally six times in five days reduced Schistosoma mansoni infection in mice by about 50%. The same regimen of tartar emetic given in a 50% aqueous solution of glycerin reduced the infection by about 74%; the same regimen of stibophen given in a 25% aqueous solution of glycerin reduced the infection by about 79%. Glycerin given alone either orally or parenterally did not kill any schistosomes. Multiple injections of 25% glycerin solutions of tartar emetic or stibophen into the tail vein of mice usually resulted in haematoma and leakage of the drug into the tissues. The acute toxicity of both tartar emetic and stibophen for uninfected mice was similar irrespective of whether the drugs were given in aqueous or in glycerin solution or as single or multiple doses; similar results were obtained with uninfected dogs. Luttermoser discusses the possible ways in which glycerin might enhance the activity of these drugs; the stability of tartar emetic in vitro was increased by the addition of glycerin, which suggests that in vivo this adjuvant could maintain the level of the drug in the blood for a longer period of time so enhancing its activity. J. W. Smith. KW - adjuvants KW - drug therapy KW - emetics KW - in vitro KW - infections KW - regimens KW - schistosomiasis KW - snail-borne diseases KW - stibophen KW - toxicity KW - toxicology KW - trematode infections KW - dogs KW - mice KW - Schistosoma KW - Schistosoma mansoni KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - small mammals KW - eukaryotes KW - Muridae KW - rodents KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Schistosoma KW - antimonials KW - antimonyl potassium tartrate KW - bilharzia KW - bilharziasis KW - chemotherapy KW - fluke infections KW - in vivo KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802748&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Hepato-splenic schistosomiasis in mice. AU - DEWITT, W. B. AU - WARREN, K. S. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1959/// VL - 8 IS - 4 SP - 440 EP - 446 SN - 0002-9637 AD - DEWITT, W. B.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19600800950. Publication Type: Journal Article. Language: not specified. N2 - Mice infected with approximately 125 cercariae of Schistosoma mansoni harboured an average burden of 24 worms per animal. In the liver maximum egg density was reached at eight weeks after infection (1, 765 per gm.). At ten weeks the mice showed symptoms which are normally associated with the syndrome designated hepato-splenic schistosomiasis, namely, liver enlargement with granulomatous lesions or scar tissue around deposited eggs, splenomegaly, oesophageal varices and ascites. Some mice also developed a severe anaemia. Histológical examination revealed little damage to liver parenchyma. Liver function test results could be attributed to abnormal conditions produced by portal hypertension. These observations suggested that the pathogenesis of the syndrome was directly related to mechanical obstruction of the portal blood flow produced by tissue reaction associated with schistosome eggs. J. E. D. Keeling. KW - anaemia KW - ascites KW - cercariae KW - granuloma KW - hepatomegaly KW - hypertension KW - infections KW - liver KW - liver cells KW - liver function KW - oesophagus KW - parenchyma KW - pathogenesis KW - portal hypertension KW - schistosomiasis KW - snail-borne diseases KW - spleen KW - splenomegaly KW - symptoms KW - trematode infections KW - mice KW - Schistosoma KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - small mammals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Schistosoma KW - anemia KW - bilharzia KW - bilharziasis KW - esophagus KW - fluke infections KW - hepatocytes KW - high blood pressure KW - liver enlargement KW - schistosomosis KW - Strigeida KW - syndromes KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19600800950&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Recent advances in carbohydrate biochemistry of helminths. AU - Brand, T. von JO - Helminthological Abstracts JF - Helminthological Abstracts Y1 - 1960/// VL - 29 IS - 2 SP - 97 EP - 111 CY - Wallingford; UK PB - CABI Publishing AD - Brand, T. von: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, USA. N1 - Accession Number: 20063028328. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Helminthology; Veterinary Science KW - biochemistry KW - biosynthesis KW - carbohydrate metabolism KW - carbohydrates KW - helminths KW - polysaccharides KW - reviews KW - complex carbohydrates KW - parasitic worms KW - saccharides KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000) KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) KW - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000) KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063028328&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A three-year epidemiologic study of intestinal parasites in a selected group of mental patients. AU - JEFFERY, G. M. JO - American Journal of Hygiene JF - American Journal of Hygiene Y1 - 1960/// VL - 71 IS - 1 SP - 1 EP - 8 AD - JEFFERY, G. M.: Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, P.O. Box 717, Columbia, South Carolina, U.S.A. N1 - Accession Number: 19600800985. Publication Type: Journal Article. Language: not specified. N2 - Incidence of parasites was studied over a three-year period in mental patients, 110 for the total duration with nine examinations, and 199 for varying duration with one to eight examinations. The incidence and persistence of hookworms, Strongyloides stercoralis and Trichuris trichiura are tabulated and discussed. During the early stages of the survey the patients were housed in an old dilapidated hospital; they were then transferred to a new modern building and the implication of improved sanitation studied. Transmission of hookworm ceased and that of S. stercoralis and T. trichiura was greatly reduced. Hookworm and T. trichiura persisted for the three-year period in most cases. [No mention is made of treatment.] N. A. Hancock. KW - animal parasitic nematodes KW - developmental stages KW - helminths KW - hookworms KW - human diseases KW - incidence KW - mental retardation KW - nematode infections KW - parasites KW - sanitation KW - Ancylostomatidae KW - man KW - Strongyloides KW - Strongyloides stercoralis KW - Trichuris KW - Trichuris trichiura KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Strongyloididae KW - Strongyloides KW - Trichuridae KW - Trichuris KW - Adenophorea KW - Enoplida KW - growth phase KW - intestinal parasites KW - mental deficiency KW - mentally handicapped KW - parasitic worms KW - Rhabditida KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Reproduction and Development (LL210) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19600800985&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - The prophylactic and curative activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine (Hoechst S 688)in experimental schistosome infections. AU - LUTTERMOSER, G. W. AU - BRUCE, J. I. AU - MCMULLEN, D. B. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1960/// VL - 9 IS - 1 SP - 39 EP - 45 SN - 0002-9637 AD - LUTTERMOSER, G. W.: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, N.I.H., P.H.S., U.S. Department of Health, Education & Welfare, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610802750. Publication Type: Journal Article. Language: not specified. N2 - Luttermoser et al. have tested the prophylactic and curative activity of 1-maleinyl-4-(3'-chloro-4'-methyl-phenyl)-piperazine sodium salt (Hoechst S 688) against experimental infections of Schistosoma mansoni in mice and monkeys and S. japonicum in dogs. Treatment of S. mansoni in monkeys with 240 mg. per kg. body-weight of S 688 for two days was successful but approached toxic levels. 10 mg. per kg. of the drug given once daily for five days did not affect S. japonicum in a dog. 72 mg. per kg. or 120 mg. per kg. of S 688 given to mice up to 72 hours after exposure to S. mansoni cercariae brought about a significant reduction in worm burdens compared with those of control mice; this was not observed for monkeys. Slight prophylactic activity of the drug was observed in preventing the development of S. japonicwn in dogs given the drug for three days following exposure to cercariae. These findings are in agreement with those of Lámmler [for abstract see Helm. Abs., 27, No. 317a]. J. W. Smith. KW - cercariae KW - control KW - experimental infections KW - infections KW - prophylaxis KW - rodent control KW - dogs KW - mice KW - monkeys KW - Schistosoma KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - small mammals KW - eukaryotes KW - Muridae KW - rodents KW - Primates KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Schistosoma KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802750&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Unsaponifiable lipids of Taenia taeniaeformis and Moniezia sp. AU - THOMPSON, M. J. AU - MOSETTIG, E. AU - VON BRAND, T. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1960/// VL - 9 IS - 2 SP - 127 EP - 130 PB - New York SN - 0014-4894 AD - THOMPSON, M. J.: Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610800396. Publication Type: Journal Article. Language: not specified. Registry Number: 57-88-5. N2 - Thompson et al. found that cholesterol formed 98% and 85% of the unsaponifiable material from Taenia taeniaeformis and Moniezia sp. respectively. Friedelin was not found. 7-ketocholesterol which was formed during the isolation and storage of the unsaponifiable material, was obtained from Moniezia, but was absent from unsaponifiable material from T. taeniaeformis. W. P. Rogers. KW - cholesterol KW - storage KW - Anoplocephalidae KW - Moniezia KW - Taenia KW - Taenia taeniaeformis KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Anoplocephalidae KW - Taeniidae KW - Taenia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610800396&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - The effects of low concentrations of sodium pentachlorophenate on the fecundity and egg viability of Australorbis glabratus. AU - OLIVIER, L. AU - HASKINS, W. T. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1960/// VL - 9 IS - 2 SP - 199 EP - 205 SN - 0002-9637 AD - OLIVIER, L.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19600802032. Publication Type: Journal Article. Language: not specified. Registry Number: 131-52-2. N2 - Tests of the effect of sodium pentachlorophenate in concentrations of 0.05 and 0.1 p.p.m. on egg-laying and the viability of the eggs of Australorbis glabratus were performed in the laboratory. The tests lasted for seven to eight days after which the water was changed and replaced with untreated water to show possible recovery of egg production and viability. Withdrawal of the chemical was followed by greater egg-laying activity and increased viability. The lower concentration was found to be rather too low, the effect of 0.1 p.p.m. being very much better. W. K. Dunscombe. KW - aquatic animals KW - egg production KW - fecundity KW - freshwater molluscs KW - sodium pentachlorophenoxide KW - Biomphalaria KW - Biomphalaria glabrata KW - Mollusca KW - snails KW - Planorbidae KW - Gastropoda KW - Mollusca KW - invertebrates KW - animals KW - snails KW - aquatic animals KW - aquatic organisms KW - eukaryotes KW - Biomphalaria KW - PCP-Na KW - sodium pentachlorophenate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19600802032&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Observations on function, composition, and structure of cestode calcareous corpuscles. AU - ON BRAND, T. AU - MERCADO, T. I. AU - NYLEN, M. U. AU - SCOTT, D. B. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1960/// VL - 9 IS - 3 SP - 205 EP - 14 PB - New York SN - 0014-4894 AD - ON BRAND, T.: U.S. Depart ment of Health, Education and Welfare, PHS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19610802674. Publication Type: Journal Article. Language: not specified. Registry Number: 124-38-9, 7439-95-4. N2 - Von Brand et al. found that the calcareous corpuscles in Taenia taeniaeformis (3.1% of the fresh weight) and Cysticercus fasciolaris (6.9%) yielded on analysis, calcium, magnesium, phosphorus and carbon dioxide. Only small amounts of nitrogen were present (0.3% in corpuscles of T. taeniaeformis) and it is possible that 15% of the weight of the corpuscles was due to a rather easily volatilized inorganic compound. Crystalline material could not be detected by X-ray diffraction or by electron microscopy. The lamellae in the corpuscles seem to be made up of paired membranous rings. Histochemical tests, in addition to revealing the inorganic material, showed that the corpuscles contained polysaccharide, a muco-polysaccharide and proteins. Metabolic experiments indicated that the corpuscles serve to buffer acids entering from the medium and also, possibly, to protect the parasites against acids produced within their own tissues. W. P. Rogers. KW - carbon dioxide KW - magnesium KW - parasites KW - polysaccharides KW - X ray diffraction KW - Cestoda KW - Taenia KW - Taenia taeniaeformis KW - Taeniidae KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Taenia KW - complex carbohydrates KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802674&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - GEN T1 - Catalogue of arthropod-borne viruses of the world. A collection of data on registered arthropod-borne animal viruses. AU - TAYLOR, Richard M. T2 - Catalogue of arthropod-borne viruses of the world. A collection of data on registered arthropod-borne animal viruses. Y1 - 1967/// PB - U.S. Government Printing Office, Washington, D.C. 20402. AD - TAYLOR, Richard M.: Bethesda: National Institutes of Health, Maryland 20014, U.S.A. N1 - Accession Number: 19692900279. Publication Type: Book. Language: not specified. N2 - See Abstr. Hyg., 1968, v. 43, p. 1397. KW - animal diseases KW - animal viruses KW - human diseases KW - vector-borne diseases KW - viral diseases KW - arthropods KW - man KW - viruses KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19692900279&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - GEN T1 - Some observations on the transmission of simian malaria. AU - COLLINS, W. E. T2 - Proceedings. New Jersey Mosquito Extermination Association, 1969 JO - Proceedings. New Jersey Mosquito Extermination Association, 1969 JF - Proceedings. New Jersey Mosquito Extermination Association, 1969 Y1 - 1969/// SP - 152 EP - 158 AD - COLLINS, W. E.: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Chamblee, Georgia 30341, USA. N1 - Accession Number: 19721000443. Publication Type: Conference paper. Language: not specified. N2 - Malaria parasites from non-human primates can serve as laboratory models for the study of human parasites. P. knowlesi and P. coatneyi are in some respects biologically similar to P. falciparum, P. cynomolgi bastianellii to P. vivax, P. fieldi to P. ovale and P. inui to P. malariae. Results are given of studies on the infection of five species of Anopheles with the five simian parasites [cf. 55 565; 58 6, 338, 1139, etc.]. A. balabacensis balabacensis Baisas and A. maculatus Theo, transmitted P. cynomolgi by bite. A. b. balabacensis was the only Anopheline tested that could transmit all five species of Plasmodium. KW - infections KW - malaria KW - parasites KW - Anopheles KW - Anopheles balabacensis KW - Anopheles maculatus KW - Culicidae KW - man KW - monkeys KW - Plasmodium KW - Plasmodium cynomolgi KW - Plasmodium falciparum KW - Plasmodium knowlesi KW - Plasmodium malariae KW - Plasmodium ovale KW - Plasmodium vivax KW - Primates KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000443&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Observations on the development of Trypanosoma rangeliin the hemocoel of Rhodnius prolixus. AU - TOBIE, E. J. JO - Journal of Invertebrate Pathology JF - Journal of Invertebrate Pathology Y1 - 1970/// VL - 15 IS - 1 SP - 118 EP - 125 SN - 0022-2011 AD - TOBIE, E. J.: Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721000980. Publication Type: Journal Article. Language: English. Number of References: 14 ref. KW - Rhodnius KW - Rhodnius prolixus KW - Trypanosoma KW - Triatominae KW - Reduviidae KW - Heteroptera KW - Hemiptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Rhodnius KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000980&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Plants used against cancer. A survey [continued]. AU - Hartwell, J. L. JO - Lloydia JF - Lloydia Y1 - 1971/// VL - 34 IS - 4 SP - 386 EP - 438 AD - Hartwell, J. L.: National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19720301713. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Horticultural Science N2 - This final part of the series covers members of the Verbenaceae to the Zygophyllaceae, in alphabetical order, and also mosses, liverworts, algae, lichens, fungi and bacteria. [For previous part see HcA 42, 6720.]. KW - lichens KW - medicinal plants KW - medicinal properties KW - surveys KW - USA KW - algae KW - bacteria KW - fungi KW - liverworts KW - mosses KW - plants KW - aquatic plants KW - aquatic organisms KW - eukaryotes KW - prokaryotes KW - Bryophyta KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - drug plants KW - medicinal herbs KW - officinal plants KW - United States of America KW - Plant Science (General) (FF000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720301713&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of ageing on amino acid turnover and rate of protein synthesis in the blowfly Phormia regina. AU - LEVENBOOK, L. AU - KRISHNA, I. JO - Journal of Insect Physiology JF - Journal of Insect Physiology Y1 - 1971/// VL - 17 IS - 1 SP - 9 EP - 12 SN - 0022-1910 AD - LEVENBOOK, L.: Laboratory of Physical Biology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721001322. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 57-50-1. N2 - Larvae of Phormia regina (Mg.) were reared on horsemeat and adults fed on sucrose and water in an insectary at 24°C, 70-75% R.H. and 14 h of illumination of about 10 ft-candles per day. Young adults 5 to 6 days old and aged flies 37 to 40 days old were selected for comparative study. Groups of four young flies and four aged flies from three consecutive generations were injected with alanine labelled with 14C, and comparable groups from two of the three generations were injected with lysine labelled with 14C. Each insect was injected with the same amount of one or the other of the labelled amino acids in neutral, aqueous solution, and after intervals of 30, 60, 90 or 120 min individual flies were analysed for total free pool of the injected amino acid, total counts in this pool, total protein, and counts in the entire protein alanine or lysine, according to which was injected. The results showed no significant difference between young and old flies in the size of their respective free alanine and lysine pools. The turnover rates of both free alanine and lysine were lower in aged as compared with young flies. The protein content of aged flies was about 86% of that of young flies. The protein lysine content remained constant with age (1.40 µmoles/fly), but the protein alanine content of young flies (1.45 µmoles/fly) was higher than that of old flies (1.21 µmoles/fly). The rates of incorporation of both alanine and lysine into protein were significantly lower in old flies than in young ones. KW - larvae KW - protein content KW - protein synthesis KW - sucrose KW - Phormia KW - Phormia regina KW - Calliphoridae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Phormia KW - protein biosynthesis KW - saccharose KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001322&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - The use of hypodermic needles as scalpels for insect micro-dissection. AU - BURTON, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1971/// VL - 31 IS - 1 SP - 113 EP - 114 AD - BURTON, G. J.: National Cancer Institute Building 37, National Institute of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721000050. Publication Type: Journal Article. Language: English. KW - entomology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000050&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Insect aspirators made from plastic or glass serological pipettes. AU - BURTON, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1971/// VL - 31 IS - 2 SP - 220 EP - 220 AD - BURTON, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721000590. Publication Type: Journal Article. Language: not specified. Language of Summary: English. KW - entomology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000590&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - A simple inexpensive styrofoam chamber for long-term holding of adult mosquitoes. AU - BURTON, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1971/// VL - 31 IS - 2 SP - 220 EP - 221 AD - BURTON, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721000591. Publication Type: Journal Article. Language: English. N2 - If an insectary with controlled temperature and humidity is not available, mosquitos can be kept alive for up to 1-2 months, depending on the species, in humidity chambers constructed from styrofoam insulated boxes. The method, which is described, has been used successfully for the maintenance of adults of Anopheles quadrimaculatus Say, A. stephensi List., Aedes aegypti (L.) and Culex pipiens pipiens L. infected with murine leukaemia virus for long periods. KW - humidity KW - leukaemia KW - methodology KW - techniques KW - temperature KW - Aedes KW - Aedes aegypti KW - Anopheles KW - Anopheles quadrimaculatus KW - Anopheles stephensi KW - Culex KW - Culex pipiens KW - Culex pipiens pipiens KW - Culicidae KW - viruses KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Aedes KW - Anopheles KW - Culex KW - Culex pipiens KW - blood cancer KW - leucaemia KW - leukemia KW - methods KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000591&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Primary cultures of tick hemocytes as systems for arbovirus growth. AU - CORY, J. AU - YUNKER, C. E. JO - Annals of the Entomological Society of America JF - Annals of the Entomological Society of America Y1 - 1971/// VL - 64 IS - 6 SP - 1249 EP - 1254 SN - 0013-8746 AD - CORY, J.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19721001156. Publication Type: Journal Article. Language: English. Number of References: 13 ref. N2 - The following is virtually the authors' abstract. Primary cultures of haemocytes of Dermacentor andersoni Stiles were maintained in viable condition for 72-74 days as judged by their ability to support the growth of Colorado tick fever virus [cf. RAE B 59 306]. Virus-growth curves for these cultures were similar to those for primary tissue cultures of viscera of D. andersoni except that peak virus proliferation and the duration of the infection were not as pronounced. Cultures of tick haemocytes offer a relatively simple and rapid alternative to tissue cultures prepared from tick viscera. KW - growth KW - haemocytes KW - infections KW - Colorado tick fever virus KW - Dermacentor KW - Dermacentor andersoni KW - Ixodidae KW - viruses KW - Orbivirus KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dermacentor KW - hemocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001156&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Observations on Trichopteran predators of aquatic stages of Simulium damnosum and other Simulium species in Ghana. AU - Burton, G. J. AU - McRae, T. M. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1972/// VL - 9 IS - 4 SP - 289 EP - 294 SN - 0022-2585 AD - Burton, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19720500885. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Eggs, larvae and pupae of Sumulium damnosum Theo. from breeding sites in the Red Volta, White Volta and Volta rivers in Ghana were kept in the laboratory with larvae of Hydropsyche, Cheumatopsyche and Chimarra, the commonest Trichopteran larvae found in the breeding sites. No ingestion of eggs, pupae or attached larvae of Simulium was observed, but motile larvae were attacked and eaten when they touched the nets constructed by the larvae of Hydropsyche and Cheumatopsyche. Only one such attack by larvae of Chimarra was observed. The remains of Simuliid larvae were found in 5 of 50 larvae of Hydropsyche taken from the Volta rivers, in 3 of 25 larvae of Cheumatopsyche and none of 15 larvae of Chimarra. In the Dayi river in eastern Ghana, a larva of Orthotrichia was seen feeding on a pupa of S. garmsi brosskey (alcocki occidentale Freeman & De Meillon) and one of S. schoutedeni Wns. A summary of reported predation of Simuliids by Trichopteran larvae is included. KW - natural enemies KW - predators KW - prey KW - Ghana KW - Diptera KW - Hydropsyche KW - Simuliidae KW - Simulium damnosum KW - Simulium schoutedeni KW - Trichoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Hydropsychidae KW - Trichoptera KW - Diptera KW - Simulium KW - Simuliidae KW - aquatic animals KW - aquatic organisms KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - blackflies KW - buffalo gnats KW - Cheumatopsyche KW - Chimarra KW - Orthotrichia KW - Philopotamidae KW - Simulium garmsi KW - Animal Behaviour (LL300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720500885&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phoretic attachment of Simulium larvae and pupae to mayfly and dragonfly nymphs. AU - Burton, G. J. AU - McRae, T. M. JO - Mosquito News JF - Mosquito News Y1 - 1972/// VL - 32 IS - 3 SP - 436 EP - 443 AD - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19720501182. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Medical & Veterinary Entomology N2 - In the Red Volta River near Bolgalanga, Ghana, a complete pupa of Simulium adersi Pomeroy was found attached to the wing pad of a nymph of the dragonfly Zygonyx torrida (Kby.) and an empty cocoon of the same Simuliid was found attached to the head of another nymph; on a dam spillway east of Gambaga, a deteriorated pupa of S. hargreavesi Gibbins was found attached to the wing pad of a third nymph. The literature on the phoretic attachment of larvae and pupae of Simuliids to the nymphs of Odonata and Ephemeroptera is reviewed. KW - pupae KW - Ghana KW - Diptera KW - Simuliidae KW - Simulium adersi KW - Simulium hargreavesi KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Diptera KW - Simulium KW - Simuliidae KW - Aeshnidae KW - Odonata KW - aquatic animals KW - aquatic organisms KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - attached to nymphs of Zygonyx torrida in Ghana KW - blackflies KW - buffalo gnats KW - Simulium bargreavesi KW - Simulium pupae attached to numphs of, in Ghana KW - Zygonyx KW - Zygonyx torrida KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720501182&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental transmission of Toxoplasma gondii by cockroaches. AU - Wallace, G. D. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1972/// VL - 126 IS - 5 SP - 545 EP - 547 SN - 0022-1899 AD - Wallace, G. D.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Honolulu, Hawaii. N1 - Accession Number: 19730510192. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Leucophaea maderae (F.) and Periplaneta americana (l.) were evaluated as transport hosts of Toxoplasma gondii. After starved cockroaches were allowed access to feline faeces containing infective oocysts of Toxoplasma, their faeces and digestive tracts were tested for infectivity in mice. T. gondii was isolated from the digestive tract of cockroaches for up to 7 days after they had contact with feline faeces and from cockroach faeces for up to 9 to 10 days after contact. Cockroach faeces that were stored at room temperature (about 25 deg C) and humidity (66-78% R.H.) remained infective for mice for up to 17 days. KW - disease transmission KW - transmission KW - Blattaria KW - Periplaneta americana KW - Pycnoscelus KW - RHYPAROBIA MADERAE KW - Toxoplasma gondii KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Periplaneta KW - Blattidae KW - Oxyhaloidae KW - Rhyparobia KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - Pycnoscelus KW - American cockroach KW - Blattodea KW - Leucophaea KW - Leucophaea maderae KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730510192&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epizootiology of Venezuelan equine encephalomyelitis in the Americas. AU - Walton, T. E. AU - Johnson, K. M. JO - Journal of the American Veterinary Medical Association JF - Journal of the American Veterinary Medical Association Y1 - 1972/// VL - 161 IS - 11 SP - 1509 EP - 1515 SN - 0003-1488 AD - Walton, T. E.: Middle America Research Unit, National Institute of Allergy and Infectious Diseases, Balboa Heights, Panama Canal Zone. N1 - Accession Number: 19730505452. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science N2 - This review includes published and unpublished information up to 1972. KW - America KW - Central America KW - North America KW - South America KW - USA KW - Culicidae KW - Diptera KW - equine encephalomyelitis virus KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Alphavirus KW - Togaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - mosquitoes KW - United States of America KW - Venezuelan equine encephalitis KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730505452&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A simple tissue press for initiating cell cultures from mosquito eggs, larvae, pupae, or adults or their organs. AU - BURTON, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1972/// VL - 32 IS - 1 SP - 112 EP - 113 AD - BURTON, G. J.: National Cancer Institute, National Institutes of Health. Bethesda, Maryland 20014, USA. N1 - Accession Number: 19721001658. Publication Type: Journal Article. Language: English. Number of References: 12 ref. KW - cell cultures KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001658&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Transmission of Plasmodium falciparum from monkey to monkey by the bite of infected Anopheles free borni mosquitoes. AU - COLLINS, W. E. AU - CONTACOS, P. G. JO - Transactions of the Royal Society of Tropical Medicine and Hygiene JF - Transactions of the Royal Society of Tropical Medicine and Hygiene Y1 - 1972/// VL - 66 IS - 2 SP - 371 EP - 372 AD - COLLINS, W. E.: Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Chamblee, Georgia 30341, USA. N1 - Accession Number: 19721001316. Publication Type: Journal Article. Language: English. Number of References: 5 ref. KW - bites KW - Anopheles KW - Culicidae KW - monkeys KW - Plasmodium KW - Plasmodium falciparum KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001316&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - Feeding of Simulium hargreavesi Gibbins larvae on Oedegonium algal filaments in Ghana. AU - Burton, G. J. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1973/// VL - 10 IS - 1 SP - 101 EP - 106 SN - 0022-2585 AD - Burton, G. J.: National Cancer Institute, Landlow Building, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19730505519. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology N2 - On a dam spillway of earth and rocks at Nalerigu, in the Northern Region of Ghana, huge numbers of larvae of Simulium hargreavesi Gibbins were found feeding exclusively by grazing on filaments of the green algae Oedogonium inconspicuum and O. moniliforme and on organic debris trapped among the filaments. More than 200 larvae were dissected and the contents of the mid-gut examined. The narrower species, O. inconspicuum (3.4-5 mu m in diameter), was found in the gut in pieces 100-1500 mu m long, mostly in the 165-500 mu m range. The pieces of the wider species, O. moniliforme (8.5-10 mu m in diameter), in the gut ranged in length from 65-1000 mu m, but those over 500 mu m were few. The findings by other investigators of Simuliid larvae feeding on filamentous algae are reviewed, together with reported deterrent effects of such algae. The possibilities of control of grazing species through absorption, adsorption and residual retention of insecticides by the filaments are also discussed. The appearance of the masses of larvae on the filaments and the two species of Oedogonium from dissected larvae are illustrated by photographs. KW - Ghana KW - Diptera KW - Simuliidae KW - Simulium hargreavesi KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Diptera KW - Simulium KW - Simuliidae KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - blackflies KW - buffalo gnats KW - Oedogonium KW - Oedogonium inconspicuum KW - Oedogonium moniliforme KW - Simulium hargreavesi feeding KW - Animal Behaviour (LL300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730505519&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intermediate and transport hosts in the natural history of Toxoplasma gondii. AU - Wallace, G. D. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1973/// VL - 22 IS - 4 SP - 456 EP - 464 SN - 0002-9637 AD - Wallace, G. D.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii. N1 - Accession Number: 19730586080. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Studies were carried out on rodents, birds, geckos and a cockroach as intermediate or transport hosts of Toxoplasma gondii, a protozoan parasite, the only definitive hosts of which appear to be Felids as this is the only group of animals in which the resistant oocyte stage develops. In experiments with Leucophaea maderae (F.), the starved cockroaches were given access to cat faeces known to contain sporulated oocysts for 5 days. Viable oocysts were found to be harboured in the digestive tract of the cockroaches, when they were starved, for up to 20 days, but not for 27 or 34 days, after the infective feed. KW - persistence KW - Blattaria KW - Pycnoscelus KW - RHYPAROBIA MADERAE KW - Toxoplasma gondii KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Oxyhaloidae KW - Rhyparobia KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - Pycnoscelus KW - Blattodea KW - Leucophaea KW - Leucophaea maderae KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730586080&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A potential antileukemic substance present in Allium ascalonicum. AU - Caldes, G. AU - Prescott, B. JO - Planta Medica JF - Planta Medica Y1 - 1973/// VL - 23 IS - 1 SP - 99 EP - 100 SN - 0032-0943 AD - Caldes, G.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19730307359. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Horticultural Science N2 - Aqueous extracts of shallot bulbs, having antileukemic activity, had a high concentration of carbohydrates and a full spectrum of amino acids on hydrolysis. KW - amino acids KW - bulbs KW - carbohydrates KW - composition KW - medicinal plants KW - shallots KW - vegetables KW - Alliaceae KW - Allium ascalonicum KW - Allium cepa var. aggregatum KW - Liliales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Allium KW - Alliaceae KW - Liliaceae KW - Allium cepa KW - drug plants KW - medicinal herbs KW - officinal plants KW - saccharides KW - vegetable crops KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730307359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mosquito rearing and sorting chambers made from eggshells and egg containers. AU - Burton, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1973/// VL - 33 IS - 1 SP - 108 EP - 110 AD - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19730507950. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology N2 - Methods of adapting egg-shells and egg containers for use as rearing units for mosquito larvae are described. The top of the egg is cut off, and a miniature emergence cage is fixed over the opening by means of an expanded key ring. The lids of egg containers can be used to sort mosquito catches. KW - apparatus KW - rearing techniques KW - Culicidae KW - Diptera KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - mosquitoes KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730507950&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aerobic bacteria in the midgut of Simulium damnosum larvae. AU - Burton, G. J. AU - Perkins, I. V. AU - Sodhi, H. S. JO - Mosquito News JF - Mosquito News Y1 - 1973/// VL - 33 IS - 1 SP - 115 EP - 117 AD - Burton, G. J.: National Cancer Institute, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19730507954. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Animal Nutrition; Medical & Veterinary Entomology N2 - The mid-gut contents of 20 mature larvae of Simulium damnosum Theo. collected in the Upper Region of Ghana were cultured in simple media to determine the numbers and kinds of aerobic bacteria present. Species of Azotobacteraceae were present in all larvae, those of Bacillaceae in 7 and those of Micococcaceae and Pseudomoadaceae in 1 each. The numbers of colonies of aerobic bacteria after incubation for 2 days at 25 deg C ranged from 89 000 to 4 million in cultures from 10 other larvae. Fungi were also present. KW - Ghana KW - Diptera KW - Simuliidae KW - Simulium damnosum KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Diptera KW - Simulium KW - Simuliidae KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - aerobic bacteria KW - blackflies KW - buffalo gnats KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730507954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The hypothesis of extrahuman reservoirs of Rickettsia prowazekii. AU - Ormsbee, R. A. JO - Scientific Publication, Pan American Health Organization JF - Scientific Publication, Pan American Health Organization Y1 - 1973/// IS - 263 SP - 104 EP - 109 AD - Ormsbee, R. A.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19740514125. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology KW - reservoirs KW - Anoplura KW - Rickettsia prowazekii KW - Phthiraptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - water reservoirs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740514125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Possible extrahuman reservoirs of Rickettsia prowazekii: ticks [including species of Amblyomma, Hyalomma, Dermacentor and Ornithodoros]. AU - Burgdorfer, W. JO - Scientific Publication, Pan American Health Organization JF - Scientific Publication, Pan American Health Organization Y1 - 1973/// IS - 263 SP - 109 EP - 113 AD - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19740514126. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology KW - reservoirs KW - Acari KW - Amblyomma KW - Dermacentor KW - Hyalomma KW - Ornithodoros KW - Rickettsia prowazekii KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodidae KW - Metastigmata KW - Acari KW - Argasidae KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - water reservoirs KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740514126&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rickettsial plaques in mosquito cell monolayers. AU - Cory, J. AU - Yunker, C. E. JO - Acta Virologica JF - Acta Virologica Y1 - 1974/// VL - 18 IS - 6 SP - 512 EP - 513 SN - 0001-723X AD - Cory, J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 50840, USA. N1 - Accession Number: 19750526130. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science N2 - Well defined plaques were obtained from two spotted fever group rickettsiae, Rickettsia rickettsi and R. conori, in Singh's lines of cells of Aedes albopictus (Skuse). KW - cell lines KW - mosquito nets KW - Tissue culture KW - Aedes KW - Aedes albopictus KW - Culicidae KW - Diptera KW - Rickettsia conorii KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Aedes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Asian tiger mosquito KW - bacterium KW - mosquitoes KW - plaque formation KW - Rickettsia conori KW - Rickettsia conoriin KW - Rickettsia rickettsi KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750526130&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Scorpion toxin-induced catecholamine release from synaptosomes. AU - Moss, J. AU - Colburn, R. W. AU - Kopin, I. J. JO - Journal of Neurochemistry JF - Journal of Neurochemistry Y1 - 1974/// VL - 22 IS - 2 SP - 217 EP - 221 SN - 0022-3042 AD - Moss, J.: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19750526117. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 51-40-1, 51-41-2, 69815-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - A toxin purified from crude venom of the scorpion L[eiurus] quinquestriatus (Hemprich & Ehrenberg) released norepinephrine from synaptosomes prepared from rat brain. The toxin-induced release was dependent on duration of exposure and concentration of toxin in the medium. KW - norepinephrine KW - venoms KW - Arachnida KW - Leiurus quinquestriatus KW - RATS KW - Scorpiones KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leiurus KW - Buthidae KW - Scorpiones KW - Arachnida KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - inducing release of catecholamines from synaptosomes KW - noradrenaline KW - rat brain synaptosomes KW - venom KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750526117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Zoonotic potential (Rocky Mountain spotted fever and tularemia) in the Tennessee Valley region. II. Prevalence of Rickettsia rickettsi and Francisella tularensis in mammals and ticks from Land Between the Lakes. AU - Burgdorfer, W. AU - Cooney, J. C. AU - Thomas, L. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1974/// VL - 23 IS - 1 SP - 109 EP - 117 SN - 0002-9637 AD - Burgdorfer, W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19740514055. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science N2 - A survey was conducted from July 1969 to January 1972 in Land Between the Lakes, an outdoor recreation and conservation education area in the Tennessee Valley region, to determine the occurrence of Rickettsia rickettsi and Pasteurella (Francisella) tularensis, the agents of spotted fever and tularaemia, respectively, in wild mammals and their ticks (cf. preceeding abstract]. Serological evidence suggested that both pathogens are widely distributed among a large variety of medium-sized mammals throughout the area. Fifty-five of 666 sera (from 8 of the 22 species of mammals sampled had complement-fixing antibodies to spotted fever antigens, with sera from cottontail rabbits (32 of 66 examples), raccoons (8 of 163) and woodchucks (6 of 49) giving the largest number of positive reactions. Antibodies to tularaemia were detected in 117 of 620 sera, with the highest prevalence among striped skunks (11 of 16), grey foxes (37 of 72), raccoons (73 of 161) and woodchucks (17 of 48).Dermacentor variabilis (Say) was the only species of tick from which R. rickettsi and P. tularensis were isolated. Of 931 adults collected off host animals or by dragging, 51 were infected with R. rickettsi; 39 of these yielded strains pathogenic for laboratory animals. Seven ticks, two of them also infected with R. rickettsi, contained P. tularensis. An unidentified bacterium-like micro-organism was detected in the haemolymph of 80 examples of D. variabilis. This organism appeared unrelated to rickettsiae and proved non-pathogenic for meadow voles. A rickettsia-like organism antigenically related to the spotted fever group was noted in 64 of 545 examples of Amblyomma americanum (L.); it also failed to produce detectable infection or antibodies to spotted fever group antigens in meadow voles. KW - animal diseases KW - infections KW - rickettsial diseases KW - Rocky Mountain spotted fever KW - tularaemia KW - wild animals KW - wildlife KW - Zoonoses KW - Kentucky KW - Tennessee KW - USA KW - Acari KW - Amblyomma americanum KW - canidae KW - dermacentor KW - Dermacentor variabilis KW - FRANCISELLA TULARENSIS KW - lagomorpha KW - mammals KW - Marmota monax KW - Mephitis mephitis KW - METASTIGMATA KW - Procyon lotor KW - Rickettsia rickettsii KW - Rickettsiales KW - Sylvilagus floridanus KW - Urocyon KW - Urocyon cinereoargenteus KW - Vulpes KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Amblyomma KW - Ixodidae KW - Metastigmata KW - Acari KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - Dermacentor KW - Francisella KW - Francisellaceae KW - Thiotrichales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Marmota KW - Sciuridae KW - rodents KW - Mephitis KW - Mustelidae KW - Procyon KW - Procyonidae KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Sylvilagus KW - Leporidae KW - Lagomorpha KW - Canidae KW - Urocyon KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Appalachian States of USA KW - Southern States of USA KW - USA KW - East South Central States of USA KW - bacterium KW - Ixodoidea KW - lone star tick KW - Pasteurella tularensis KW - Rickettsia rickettsi KW - ticks KW - tularemia KW - United States of America KW - variabilis KW - VULPES CINEREOARGENTEUS KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biological Resources (Animal) (PP710) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740514055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of Plasmodium vivax in chemosterilized Anopheline mosquitoes. AU - Omar, M. S. AU - Collins, W. E. AU - Gwadz, R. W. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1974/// VL - 23 IS - 3 SP - 334 EP - 338 SN - 0002-9637 AD - Omar, M. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341, USA. N1 - Accession Number: 19740517359. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Studies were carried out to determine the effect of pupal chemosterilisation on the susceptibility of the resulting adults of Anopheles albimanus Wied. and A. freeborni Aitken to infection with Plasmodium vivax. The mosquitos were sterilised by exposing pupae for 1, 2 or 4 h in 1% aqueous solution of ENT-61585 (P,P-bis(1-aziridinyl)-N-methylphosphinothioic amide). Complete sterility resulted from treatment for 1 h in the case of males and females of A. albimanus and males of A. freeborni, but virtually complete sterility was only achieved after exposure for 4 h in the case of females of A. freeborni. The difference in susceptibilty to P. vivax between sterilised and normal mosquitos was more pronounced in A. albimanus than in A. freeborni. The over-all infection rate of sterile females of A. albimanus was significantly less (26%) than that of untreated ones (69%). In the case of A. freeborni, however, a less marked effect was noticed, the corresponding figures being 56 and 75%. Sporogony was completed in sterilised mosquitos, motile sporozoites being found in the salivary glands. KW - chemosterilants KW - infectivity KW - mosquito nets KW - sterilants KW - Anopheles albimanus KW - Anopheles freeborni KW - Culicidae KW - Diptera KW - Plasmodium vivax KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - phosphinothioic amide, P,P-bis(1-aziridinyl)-N-methyl- KW - Plasmodium susceptibility KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740517359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Studies on the antimalarial effects of RC-12 and WR 14,977 on the development of Plasmodium cynomolgi in mosquitoes and rhesus monkeys. AU - Omar, M. S. AU - Collins, W. E. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1974/// VL - 23 IS - 3 SP - 339 EP - 349 SN - 0002-9637 AD - Omar, M. S.: National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341, USA. N1 - Accession Number: 19740517360. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The activity of RC-12 (1,2-dimethoxy-4-(bis(2-(diethylamino)-ethyl)amino)-5-bromobenzene) and WR 14997 (1-aminocyclopentanecarboxylic acid) against gametocytes and the sporogonic cycle of Plasmodium cynomolgi was studied in Macaca mulatta and Anopheles maculatus Theo. The effect of the drugs on the mosquito stages of the parasite was assessed both after treatment by gavage of infected monkeys, on which the mosquitos were fed, and direct administration in sugar solution to infected mosquitos. Single or multiple doses of RC-12 at 25 mg/kg a day administered to the monkeys were equally effective against gametocytes and the sporogonic cycle of the parasite. Mosquito infection was interrupted within 8 to 24 h following initial treatment. The feeding of RC-12 at 0.1-1.0% in 10% sugar solution to infected mosquitos resulted in no discernible effects on oocyst development or sporozoite formation in the mosquito. The salivary glands of treated mosquitos displayed marked morpho-pathological alterations as a result of drug ingestion. Repeated daily doses of WR 14997 at 60 mg/kg or 100 mg/kg administered to the monkeys had no significant gametocidal, sporontocidal or prophylactic activity against P. cynomolgi after being administered to the monkey host. In contrast, WR 14997 exhibited a marked sporontocidal action against the parasite when the drug was administered directly to the mosquitos.These results do not support the assumption that there is a correlation in drug response between the sporogonic cycle of the malaria parasite in the invertebrate host and the tissue stages of the same parasite in the vertebrate host when the drug is fed directly to the mosquito [cf. RAE/B 59, 445]. However, there apears to be a direct relationship between the effect of the drug on the gametocyte and tissue stages when it is administered to the vertebrate host prior to mosquito feeding. KW - antimalarials KW - mosquito nets KW - Anopheles maculatus KW - Culicidae KW - Diptera KW - Macaca mulatta KW - Plasmodium KW - Plasmodium cynomolgi KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - 1,2-ethanediamine, N-(2-bromo-4,5-dimethoxyphenyl)-N-[2-(diethylamino)ethyl]-N',N'-diethyl- KW - cyclopentanecarboxylic acid, 1-amino- KW - Haemosporida KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740517360&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential uptake of tritiated thymidine and adenine by the mosquito Aedes aegypti infected with the filarial nematode Brugia pahangi. AU - Omar, M. S. AU - Gwadz, R. W. JO - Tropenmedizin und Parasitologie JF - Tropenmedizin und Parasitologie Y1 - 1974/// VL - 25 IS - 2 SP - 167 EP - 174 AD - Omar, M. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Chamblee, Georgia, USA. N1 - Accession Number: 19740517896. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 16 ref. Registry Number: 50-89-5. Subject Subsets: Medical & Veterinary Entomology; Helminthology N2 - Little is known about the biochemical requirements of filarial nematodes developing in a mosquito host. An account is given of a study by means of autoradiography on tissue sections of the uptake and distribution of thymidine and adenine labelled with tritium fed to females of Aedes aegypti (L.) infected with Brugia pahangi. Massive incorporation of labelled thymidine was seen, primarily in the nuclei of dividing issues (ovary) as well as in non-dividing tissues (mid-gut) of the mosquito. Labelled adenine was homogeneously distributed over both cytoplasmic and nuclear regions of the ovary and mid-gut cells. Thymidine incorporation into nuclei of parasitised muscle fibres was not observed during the early stages of filarial development but coincided with the maturation and subsequent escape of filarial larvae from the muscles into the haemocoel. No thymidine was incorporated into developing individuals of B. pahangi, but a slight uptake of adenine was noted. KW - biochemistry KW - helminths KW - mosquito nets KW - nucleosides KW - parasites KW - thymidine KW - Aedes aegypti KW - Brugia KW - Brugia pahangi KW - Culicidae KW - Diptera KW - Insects KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Brugia KW - 1H-Purin-6-amine KW - adenine & thymidine uptake KW - mosquitoes KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740517896&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phlebotomine sandflies in Montana: first report. AU - Chaniotis, B. N. JO - Mosquito News JF - Mosquito News Y1 - 1974/// VL - 34 IS - 3 SP - 334 EP - 335 AD - Chaniotis, B. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19740519952. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A male and 2 females of Lutzomyia vexator occidentis (Fairchild & Hertig) and a male and 3 females of L. oppidana (Dampf) were collected near Hamilton, Montana, in 1973. These are the first records of Phlebotomines from Montana. KW - Montana KW - USA KW - Diptera KW - Lutzomyia vexator KW - Phlebotominae KW - Psychodidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Lutzomyia KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Western States of USA KW - Lutzomyia oppidana KW - Lutzomyia vexator occidentis KW - United States of America KW - Taxonomy and Evolution (ZZ380) KW - Biological Resources (Animal) (PP710) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740519952&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - National and regional health planning in Sweden. AU - NAVARRO, V. T2 - DHEW Publication Y1 - 1974/// IS - (N1H) 74-240 AD - NAVARRO, V.: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, U.S.A. N1 - Accession Number: 19762702928. Publication Type: Book. Language: not specified. N2 - This monograph is recommended to anyone who is interested in studying the Swedish health system. The author provides a comprehensive account of health care planning and services in Sweden, beginning with an explanation of the Swedish governmental process at both national and local levels. In order to correct some of the damaging myths existing about Sweden's particular problems, such as suicide, Navarro concentrates on identifying some of the common health experiences shared by industrialized societies. For example, the cost of medical and hospital care has increased in most industrialized societies owing to technological innovation in the health sector and growing demands for services. Sweden's response to these rising costs in the 1960's was to regionalize hospital services and to promote " voluntarism " in health planning-that is, the principle of bringing together different groups and institutions on a voluntary basis to reach common objectives. By the 1970's, however, the emphasis in Sweden had moved towards strengthening the planning machinery at national level and integrating hospital services and general medical care with social services. Indeed, comparisons can be drawn between the recent British reorganization of health services, aimed at removing the tripartite structure, and the Swedish experience. The author touches on this comparison but, at the time his book was published, it would have been premature to engage in lengthier comparisons on this issue. Nevertheless, a little more depth analysis and less factual description would have enlivened this text. Even so, it gives an accurate and extremely useful picture of health care planning and services in Sweden, set clearly in the framework of the country's geographical, political and socio-economic characteristics. Rosamund M. Thomas. KW - comparisons KW - government KW - health services KW - medical services KW - monographs KW - planning KW - prematurity KW - social services KW - Sweden KW - Scandinavia KW - Northern Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19762702928&site=ehost-live&scope=site DP - EBSCOhost DB - gha ER - TY - JOUR T1 - In vitro biosynthesis of oothecal sclerotization agents from tyrosine by haemolymph of Periplaneta americana. AU - Lake, C. R. AU - Mills, R. R. JO - Insect Biochemistry JF - Insect Biochemistry Y1 - 1975/// VL - 5 IS - 5 SP - 659 EP - 669 AD - Lake, C. R.: Laboratory of Clinical Science, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19750530426. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 51-67-2, 60-18-4. Subject Subsets: Medical & Veterinary Entomology N2 - Whole haemolymph of adult females of Periplaneta americana (L.) was homogenised in distilled water and the extract subjected to column chromatography on Sepharose-6B. The partially purified enzyme, when incubated with the appropriate cofactors, was capable of catalysing several reactions. With pyridoxal-phosphate and NAD but without the addition of copper, L-tyrosine labelled with 14C was metabolised to tyramine, octopamine, p-hydroxymandelic acid, p-hydroxybenzaldehyde, p-hydroxybenzyl alcohol, p-hydroxybenzoic acid, p-hydroxyphenylpyruvic acid, p-hydroxyphenylacetic acid, p-hydroxyphenyllactic acid and p-hydroxyphenylpropionic acid. The major metabolites of L-tyramine labelled with 14C were octopamine, p-hydroxymandelic acid and p-hydroxybenzoic acid. Further experiments using the crude homogenate and unlabelled substrates showed that octopamine was metabolised to p-hydroxymandelic acid and that it produced p-hydroxybenzaldehyde, p-hydroxybenzoic acid and 3,4-dihydroxybenzoic acid (protocatechuic acid). The results suggest the following pathway exists for the synthesis of protocatechuic acid: tyrosine 'right arrow' tyramine 'right arrow' octopamine 'right arrow' p-hydroxymandelic acid 'right arrow' p-hydroxyphenylglyoxylic acid or p-hydroxybenzyl alcohol, or both, 'right arrow' p-hydroxybenzaldehyde 'right arrow' p-hydroxybenzoic acid 'right arrow' protocatechuic acid. Hydroxylation of the p-hydroxy compounds occurred in the presence of copper but at different rates. The initial transamination or deamination, or both, of tyrosine to the p-hydroxypyruvate is apparently not instrumental in the synthesis of protocatechuic acid although the results of this investigation do not offer conclusive evidence concerning this question. KW - metabolism KW - synthesis KW - tyramine KW - tyrosine KW - Blattaria KW - Periplaneta americana KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Periplaneta KW - Blattidae KW - American cockroach KW - benzaldehyde, 4-hydroxy- KW - benzeneacetic acid, 4-hydroxy- KW - benzeneacetic acid, 4-hydroxy-alpha-oxo- KW - benzeneacetic acid,alpha,4-dihydroxy- KW - benzenemethanol, 4-hydroxy- KW - benzenemethanol, alpha-(aminomethyl)-4-hydroxy- KW - benzenepropanoic acid, 4-hydroxy-alpha-oxo- KW - benzenepropanoic acid,alpha,4-dihydroxy- KW - benzenepropanoic aicd, 4-hydroxy- KW - benzoic acid, 3,4-dihydroxy- KW - benzoic acid, 4-hydroxy- KW - Blattodea KW - sclerotising agents KW - synthesis from tyrosine KW - synthesis of sclerotising agents KW - tyrosine metabolite KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Animal Reproduction and Development (LL210) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750530426&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Failure of rubella virus to replicate in mosquitoes. AU - Tesh, R. B. AU - Rosen, L. JO - Intervirology JF - Intervirology Y1 - 1975/// VL - 5 IS - 3/4 SP - 216 EP - 219 SN - 0300-5526 AD - Tesh, R. B.: Pacific Research Station, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii, USA. N1 - Accession Number: 19760534119. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Rubella virus failed to replicate in females of Aedes albopictus (Skuse) and Culex pipiens fatigans Wied. (C. fatigans) following parenteral inoculation. The virus was demonstrated in females tested immediately after inoculation but was not detected in those sampled 7, 14 and 21 days after inoculation. This experiment provides further evidence that rubella is not an arbovirus but does not invalidate its classification as a togavirus. KW - mosquito nets KW - Aedes albopictus KW - Culex pipiens KW - CULEX QUINQUEFASCIATUS KW - Culicidae KW - Diptera KW - rubella virus KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Culex KW - Rubivirus KW - Togaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Culex pipiens KW - Asian tiger mosquito KW - Culex pipiens fatigans KW - mosquitoes KW - not replicating KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760534119&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiplication of Phlebotomus fever group arboviruses in mosquitoes after intrathoracic inoculation. AU - Tesh, R. B. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1975/// VL - 12 IS - 1 SP - 1 EP - 4 SN - 0022-2585 AD - Tesh, R. B.: National Institute of Allergy and Infectious Diseases, P.O. Box 1680, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19750527447. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Twenty-two arboviruses of the Phlebotomus fever group were inoculated intrathoracically into males and females of Aedes albopictus (Skuse) and Culex pipiens fatigans Wied. (C. fatigans). Eight of the viruses (Itaporanga, Arumowot, Bujarn, Karimabad, Salehabad, Pacui, Chilibre and BeAn 100049) multiplied in one or both mosquito species when these were maintained at 32 deg C for 10 days. Icoaraci virus was detected in mosquitos after the 10-day incubation period but did not increase in titre. The remaining 13 agents tested did not survive following inoculation. The results of these experiments indicate that the mosquito-inoculation technique is less effective for the propagation of Phlebotomus fever group viruses than culture in Vero cells of newborn mice. Attempts to demonstrate transovarial transmission of Itaporanga and Arumowot viruses by infected females of A. albopictus and C. p. fatigans were unsuccessful, no virus being detected in the F1 adults. KW - mosquito nets KW - persistence KW - replication KW - Aedes albopictus KW - Chilibre virus KW - CULEX QUINQUEFASCIATUS KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Culex KW - Phlebovirus KW - Bunyaviridae KW - negative-sense ssRNA Viruses KW - ssRNA Viruses KW - RNA Viruses KW - viruses KW - Culex pipiens KW - Arumowot virus KW - Asian tiger mosquito KW - BeAn 100049 virus KW - Bujarn virus KW - Culex pipiens fatigans KW - Icoaraci virus KW - Itaporanga virus KW - Karimabad virus KW - mosquitoes KW - Pacui virus KW - Phlebotomus fever viruses KW - Salehabad virus KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750527447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Records of phoretic attachment of Mallophaga (Insecta: Phthiraptera) on insects other than Hippoboscidae. AU - Keirans, J. E. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1975/// VL - 12 IS - 4 SP - 476 EP - 476 SN - 0022-2585 AD - Keirans, J. E.: US Department of Health, Education, and Welfare, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19760531465. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A few records of the occurrence of Mallophaga on Siphonaptera, Diptera (including mosquitos), Odonata, Hymenoptera and Lepidoptera are presented. Nearly all records are of Mallophaga that are normally ectoparasites of mammals. KW - Culicidae KW - Diptera KW - Hymenoptera KW - Lepidoptera KW - Mallophaga KW - Odonata KW - Siphonaptera KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Phthiraptera KW - mosquitoes KW - Siponaptera KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760531465&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of spotted fever group and Wolbachia-like agents from field-collected materials by means of plaque formation in mammalian and mosquito cells. AU - Cory, J. AU - Yunker, C. E. AU - Howarth, J. A. AU - Hokama, Y. AU - Hughes, L. E. AU - Thomas, L. A. AU - Clifford, C. M. JO - Acta Virologica JF - Acta Virologica Y1 - 1975/// VL - 19 IS - 5 SP - 443 EP - 445 SN - 0001-723X AD - Cory, J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19760537456. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Three isolations in California from Dermacentor occidentalis Marx of a rickettsia of the spotted fever group and 5 isolations from chipmunks (Eutamias ruficaudus) of a Wolbachia-like agent were obtained from plaques formed in Singh's cultures of cells of Aedes albopictus (Skuse) and Vero cell cultures. These organisms could not be isolated by injection of the infected ticks or blood into embryonated chicken eggs, guineapigs or voles (Microtus pennsylvanicus), but fluid cultures of Grace's cultures of cells of Antheraea eucalypti Scott and Singh's cultures of cells of Aedes albopictus inoculated with the blood yielded the Wolbachia-like agent. KW - cell lines KW - introduced species KW - isolation KW - mosquito nets KW - California KW - USA KW - Acari KW - Aedes albopictus KW - Culicidae KW - Dermacentor occidentalis KW - Diptera KW - Rickettsiales KW - Wolbachia KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Anaplasmataceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Antheraea KW - Saturniidae KW - Lepidoptera KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Antheraea eucalypti KW - Asian tiger mosquito KW - bacterium KW - Caligula KW - Eutamias ruficaudus KW - exotic organisms KW - exotic species KW - introduced organisms KW - mosquitoes KW - naturalized species KW - non-indigenous organisms KW - non-indigenous species KW - non-native organisms KW - non-native species KW - nonindigenous organisms KW - nonindigenous species KW - occidentalis, Dermacentor KW - Opodiphthera KW - Opodiphthera eucalypti KW - Opodipthera eucalypti KW - spotted-fever rickettsiae KW - United States of America KW - Wolbachia-like organism KW - Wolbachia-like organisms KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760537456&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rocky Mountain spotted fever (tick-borne typhus) in South Carolina: an educational program and tick/rickettsial survey in 1973 and 1974. AU - Burgdorfer, W. AU - Adkins, T. R., Jr. AU - Priester, L. E. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1975/// VL - 24 IS - 5 SP - 866 EP - 872 SN - 0002-9637 AD - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19750530471. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Because the incidence of spotted fever is increasing in South Carolina, campaigns were carried out in 1973 and 1974 to provide the public and medical practitioners, through pamphlets and news media, with information about spotted fever and the ticks that transmit the causative agent (Rickettsia rickettsi). People were also invited to save and submit live ticks removed from vegetation, animals and man for examination by the haemolymph test. A total of 1186 ticks comprising 987 examples of Dermacentor variabilis (Say), 103 of Rhipicephalus sanguineus (Latr.), and 96 of Amblyomma americanum (L.) were examined. Rickettsiae identified by direct immunofluorescence as members of the spotted fever group were detected in 49 (4.9%) of the examples of D. variabilis, and 16 (16.6%) of those of A. americanum. Two hundred and twenty of the ticks (199 of D. variabilis, 17 of A. americanum and 4 of H. sanguineus) were recorded as having been attached to 199 persons. Nine of these ticks (8 of D. variabilis and 1 of A. americanum) were positive by the haemolymph test for rickettsiae of the spotted fever group. Infected ticks were collected from each of the three major South Carolina biogeographical regions: piedmont, sandhill and coastal plain. Since education is the first and most important step in preventing spotted fever, educational programmes and tick examination services similar to those described are suggested for other states that have a high incidence of spotted fever. KW - detection KW - IMMUNOFLUORESCENCE KW - Rocky Mountain spotted fever KW - South Carolina KW - USA KW - Acari KW - Amblyomma americanum KW - Dermacentor variabilis KW - man KW - Metastigmata KW - Rhipicephalus sanguineus KW - Rickettsia rickettsii KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Amblyomma KW - Ixodidae KW - Metastigmata KW - Acari KW - Dermacentor KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Rhipicephalus KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southeastern States of USA KW - bacterium KW - fluorescent antibody technique KW - IFAT KW - lone star tick KW - Rickettsia rickettsi KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750530471&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Laboratory studies of transovarial transmission of La Crosse and other arboviruses by Aedes albopictus and Culex fatigans. AU - Tesh, R. B. AU - Gubler, D. J. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1975/// VL - 24 IS - 5 SP - 876 EP - 880 SN - 0002-9637 AD - Tesh, R. B.: Pacific Research Station, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19750530472. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology N2 - La Crosse virus was transovarially transmitted by experimentally infected females of Aedes albopictus (Skuse), which is not a natural vector of the virus, to 2.7% of their offspring in the F1 generation. Progeny of both sexes were infected. Mean virus titres were 104.6 plaque forming units/insect in parent mosquitos and 103.4 in infected F1 generation adults. The infected offspring were randomly distributed among the female parents. After two serial passages in A. albopictus, a marked change occurred in the plaque morphology of the virus but this had no apparent effect on the subsequent vertical transmission rate. In contrast, transovarial transmission did not occur in Culex pipiens fatigans Wied. (C. fatigans) infected with La Crosse virus or in A. albopictus or C. p. fatigans infected with vesicular stomatitis-Indiana, Cache Valley, Batai, Arumowot, and Itaporanga viruses. KW - mosquito nets KW - transovarial transmission KW - vesicular stomatitis viruses KW - Aedes albopictus KW - Batai virus KW - Cache Valley virus KW - Culex pipiens KW - CULEX QUINQUEFASCIATUS KW - Culicidae KW - Diptera KW - La Crosse virus KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Bunyamwera virus KW - Orthobunyavirus KW - Bunyaviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Culex KW - California encephalitis virus KW - Vesiculovirus KW - Rhabdoviridae KW - Mononegavirales KW - Culex pipiens KW - Arumowot virus KW - Asian tiger mosquito KW - Culex pipiens fatigans KW - Itaporanga virus KW - mosquitoes KW - not transmitted transovarially KW - vesicular stomatitis virus KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750530472&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A potential antileukemic substance present in Globularia alypum. AU - Caldes, G. AU - Prescott, B. AU - King, J. R. JO - Planta Medica JF - Planta Medica Y1 - 1975/// VL - 27 IS - 1 SP - 72 EP - 76 SN - 0032-0943 AD - Caldes, G.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19750328888. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Horticultural Science N2 - In a survey of medicinal plants from Greece antileukemic extracts of G. alypum were shown to contain high concentrations of carbohydrates, sugar alcohols and phenolic compounds. KW - medicinal plants KW - medicinal properties KW - Globularia alypum KW - Globularia KW - Globulariaceae KW - Scrophulariales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - drug plants KW - medicinal herbs KW - officinal plants KW - Plant Science (General) (FF000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750328888&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plaque production by arboviruses in Singh's Aedes albopictus cells. AU - Yunker, C. E. AU - Cory, J. JO - Applied Microbiology JF - Applied Microbiology Y1 - 1975/// VL - 29 IS - 1 SP - 81 EP - 89 AD - Yunker, C. E.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19750526821. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Plaquing tests are reported of 124 virus strains, mostly arboviruses of 21 serological groups, in Singh's line of cells of Aedes albopictus (Skuse). The 30 of these that plaqued were arboviruses of six groups and were known or presumed to be mosquito-borne. Those failing to plaque were 86 strains of arboviruses, mostly tick-borne, 2 strains of insect pathogens and 6 animal viruses not classified as arboviruses. Among mosquito-borne agents, plaquing ability appeared to be related to serological classification. Viruses of the California group and most of those of group A failed to plaque but nearly all members of the B and Bunyamwera groups readily plaqued. Within group B, 14 of 16 mosquito-borne agents plaqued, but none of 13 tick-borne viruses or viruses that arthropods are not known to transmit did so. Some implications of these results for the recognition and classification of arboviruses are discussed. KW - arboviruses KW - cell lines KW - mosquito nets KW - Aedes albopictus KW - Bunyamwera virus KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Orthobunyavirus KW - Bunyaviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - Asian tiger mosquito KW - California viruses KW - mosquitoes KW - not producing plaques KW - plaque production KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750526821&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Uses of the ring-tab of cans in the entomology laboratory. AU - Burton, G. J. JO - Mosquito News JF - Mosquito News Y1 - 1975/// VL - 35 IS - 3 SP - 411 EP - 412 AD - Burton, G. J.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19750530662. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology KW - apparatus KW - mosquito nets KW - Culicidae KW - Diptera KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - made from ring-tab of cans KW - mosquitoes KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750530662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of beta -(2-furoyl)-L-alanine from the hydrolyzed extracts of Koelreuteria paniculata (golden rain tree) seeds. AU - Irreverre, F. AU - Wilson, E. AU - Fales, H. M. AU - Sun, T. AU - Sokoloski, E. JO - Lloydia JF - Lloydia Y1 - 1975/// VL - 38 IS - 2 SP - 178 EP - 180 AD - Irreverre, F.: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19750331473. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Horticultural Science N2 - The structure and properties of this amino acid are described. KW - amino acids KW - composition KW - medicinal plants KW - medicinal properties KW - ornamental plants KW - ornamental woody plants KW - seeds KW - woody plants KW - Koelreuteria paniculata KW - plants KW - Koelreuteria KW - Sapindaceae KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - drug plants KW - Koelreuteria paniculata B-(2-furoyl)-1-alanine KW - medicinal herbs KW - officinal plants KW - ornamentals KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750331473&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pesticide toxicity and potential for cancer: a proper perspective. AU - Kraybill, H. F. JO - Pest Control JF - Pest Control Y1 - 1975/// VL - 43 IS - 12 SP - 10 EP - 16 SN - 0031-6121 AD - Kraybill, H. F.: National Cancer Institute, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19760532652. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 50-29-3. Subject Subsets: Agricultural Entomology N2 - In this review of studies on the possible relation between chemical pesticides and cancer, and of the means by which this may be assessed, the author discusses the significance of toxicity and the principles employed in the calculation of risk (body retention and burden of the pesticide, the possibility of a threshold, the degree of added risk, the safety margin for susceptible members of the population, the time required for tumour formation, metabolic overloading, and epidemiological verification of experimental studies). No chemicals used as pesticides have so far been conclusively proved carcinogenic to man, or to more than two species of other animals. A distinction is made between carcinogens and cocarcinogens, which operate synergistically to produce cancer in an organism already exposed to cancer risk from environmental factors or from some individual physiological weakness or injury. The possibility that DDT may be a cocarcinogen is discussed. KW - agricultural entomology KW - carcinogens KW - DDT KW - neoplasms KW - nontarget effects KW - pesticides KW - toxicity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cocarcinogenicity KW - cocarcinogens KW - dicophane KW - relation of chemical pesticides KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760532652&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Organisms mimicking Pneumocystis carinii. AU - Young, R. C. AU - Bennett, J. E. AU - Chu, E. W. T2 - Lancet JO - Lancet JF - Lancet Y1 - 1976/// VL - 2 IS - 7994 SP - 1082 EP - 1083 AD - Young, R. C.: Medicine Branch, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19772503985. Publication Type: Correspondence. Language: English. Subject Subsets: Protozoology; Medical & Veterinary Mycology N2 - Pitfalls in the diagnosis of Pneumocystis carinii are briefly discussed. The case of a patient with preleucaemia and peripheral pancytopenia is described. Organisms were seen in material obtained from bronchial brushing which seemed typical of Pneumocystis when stained with Gomovi/methamine-silver. Fungal cultures of sputum obtained after bronchoscopy grew the yeast Torulopsis glabrata. It is considered that the organism in the bronchial brushing material was probably T. glabrata and not Pneumocystis. It is thought that, normally, budding should distinguish the 2 organisms. KW - diagnosis KW - differential diagnosis KW - parasites KW - Candida KW - Candida glabrata KW - Cryptococcus (Fungi) KW - Histoplasma KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - invertebrates KW - Torulopsis KW - Candida KW - Cryptococcus (Deuteromycotina) KW - fungus KW - Hyphomycetes KW - mimicking Pneumocystis carinii KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19772503985&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Animal disease agents transmitted by horse flies and deer flies (Diptera: Tabanidae). AU - Krinsky, W. L. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1976/// VL - 13 IS - 3 SP - 225 EP - 275 SN - 0022-2585 AD - Krinsky, W. L.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19770542791. Publication Type: Journal Article. Language: English. Number of References: 7 pp. ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science; Protozoology N2 - Published reports of tabanid transmission of pathogenic agents of animals (including man) are reviewed. Experimental evidence is discussed for tabanid transmission of viruses, bacteria, Protozoa and helminths. The results of laboratory and field tests indicate that tabanids are essential to the biological transmission of the Protozoa Haemoproteus metchnikovi and Trypanosoma theileri and of the helminths Loa loa, Dirofilaria roemeri and Elaeophora schneideri, and that tabanids are mechanical vectors of the viruses of equine infections anaemia, vesicular stomatitis, hog cholera and rinderpest, the bacteria Anaplasma marginale, Bacillus anthracis, Clostridium chauvoei, Pasteurella multocida, P. tularensis (Francisella tularensis), Brucella spp., Listeria monocytogenes and Erysipelothrix rhusiopathae, the Protozoa Besnoitia besnoiti, T. evansi, T. equiperdum, T. congolense, T. brucei brucei and T. rhodesiense. The extent of the importance of tabanids in the natural mechanical transmission of most of these agents is not known. Indirect modes of transmission, involving secondary blood-feeding insects at the sites of tabanid bites or contamination by means of agents adhering to external tabanid structures are briefly discussed.<new para>ADDITIONAL ABSTRACT:<new para>The transmission by tabanids of pathogens to man and animals is comprehensively reviewed, with special emphasis on the experimental evidence. Viruses, bacteria, protozoa and helminths are dealt with separately. The species of Tabanidae recorded as hosts of specific organisms are tabulated. Laboratory and field studies indicate that tabanids are essential for the development and transmission of Haemoproteus metchnikovi and Trypanosoma theileri and that they act as mechanical vectors of Besnoitia besnoiti, T. evansi, T. equiperdum, T. congolense, T. brucei brucei and T.b. gambiense (rhodesiense). Each of these species is discussed, as well as Anaplasma marginale and Leptospira spp. KW - disease transmission KW - disease vectors KW - Epidemiology KW - equine infectious anaemia KW - Helminths KW - insect pests KW - parasites KW - reviews KW - rinderpest KW - swine fever KW - transmission KW - vesicular stomatitis viruses KW - Anaplasma marginale KW - Apicomplexa KW - Bacillus anthracis KW - Bacteria KW - Besnoitia besnoiti KW - Brucella KW - Classical swine fever virus KW - Clostridium chauvoei KW - Diptera KW - Elaeophora schneideri KW - FRANCISELLA TULARENSIS KW - insects KW - Listeria monocytogenes KW - Loa loa KW - Nematoda KW - Pasteurella multocida KW - Pelecitus KW - Pelecitus roemeri KW - Protozoa KW - SARCOMASTIGOPHORA KW - Tabanidae KW - Trypanosoma brucei KW - Trypanosoma congolense KW - Trypanosoma equiperdum KW - Trypanosoma evansi KW - Trypanosoma rhodesiense KW - Trypanosoma theileri KW - viruses KW - Anaplasma KW - Anaplasmataceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Bacillus (Bacteria) KW - Bacillaceae KW - Bacillales KW - Bacilli KW - Firmicutes KW - Besnoitia KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Brucellaceae KW - Rhizobiales KW - Pestivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - insects KW - Hexapoda KW - arthropods KW - Elaeophora KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Francisella KW - Francisellaceae KW - Thiotrichales KW - Gammaproteobacteria KW - Listeria KW - Listeriaceae KW - Loa KW - Pasteurella KW - Pasteurellaceae KW - Pasteurellales KW - Diptera KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Haemoproteus KW - Plasmodiidae KW - Haemospororida KW - Pelecitus KW - Vesiculovirus KW - Rhabdoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - African eyeworm KW - bacterium KW - cattle plague KW - Dirofilaria roemeri KW - equine infectious anemia KW - Erysipelothrix rhusiopathae KW - Haemoproteus metchnikovi KW - hog cholera KW - Mastigophora KW - nematodes KW - parasitic worms KW - Pasteurella tularensis KW - pest insects KW - Secernentea KW - Simondia KW - Simondia metchnikovi KW - Spirurida KW - Swine fever virus KW - Tabanid transmission of animal disease agents KW - Trypansoma equiperdum KW - vectors of animal disease agents KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770542791&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of different strains of Plasmodium vivax in two species of Anopheles. AU - Collins, W. E. AU - Contacos, P. G. AU - Richardson, B. B. AU - Skinner, J. C. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1976/// VL - 25 IS - 3 SP - 372 EP - 375 SN - 0002-9637 AD - Collins, W. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19760537126. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Females of Anopheles freeborni Aitken were fed on monkeys (Aotus trivirgatus) or men infected with various strains of Plasmodium vivax. Of those females that had oocysts on the gut wall, a higher proportion of those infected with New World strains of P. vivax had infections in the salivary glands than those infected with Asian, particularly South Vietnamese, strains. Females of A. maculatus Theo. supported development of all strains of P. vivax from oocysts to heavily infected salivary glands. The results suggest that strains of P. vivax that were introduced into the United States from Vietnam would be less likely to be transmitted by the native species A. freeborni than would malaria from some other areas.<new para>ADDITIONAL ABSTRACT:<new para>Anopheles freeborni with oocyst infections had salivary gland infections at a higher rate with strains of Plasmodium vivax from the New World than with strains from Asia, particularly those from South Viet Nam. A. maculatus supported development from oocysts to heavily infected salivary glands for all the strains of P. vivax tested. The results suggest that P. vivax introduced into the USA from Viet Nam would be less likely to be transmitted by native A. freeborni mosquitoes than would malaria from some other areas. [AS]. KW - development KW - insect pests KW - life history KW - mosquito nets KW - parasites KW - strains KW - Anopheles freeborni KW - Anopheles maculatus KW - Apicomplexa KW - Culicidae KW - Diptera KW - insects KW - Plasmodium vivax KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - mosquitoes KW - pest insects KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760537126&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A field trial of competitive displacement of Aedes polynesiensis by Aedes albopictus on a Pacific atoll. AU - Rosen, L. AU - Rozeboom, L. E. AU - Reeves, W. C. AU - Saugrain, J. AU - Gubler, D. J. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1976/// VL - 25 IS - 6 SP - 906 EP - 913 SN - 0002-9637 AD - Rosen, L.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, PO Box 1680, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19770540098. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Helminthology N2 - Earlier laboratory studies and field observations had suggested that it might be possible to reduce the size of populations of, or to eliminate, Aedes polynesiensis Marks by the introduction of A. albopictus (Skuse). The former species is the principal vector of non-periodic filariasis caused by Wuchereria bancrofti and the latter is a closely related species refractory to infection with human filariae. The practicability of such competitive displacement was studied in a field test on a remote coral atoll, Taiaro, in the Pacific Ocean, where there was an established population of A. polynesiensis. Three strains of A. albopictus were liberated at separate localities on the atoll, which is approximately circular and about 5 km in diameter. The fate of the released species was followed for 4 years. One strain disappeared within 12 months of release and the other two disappeared within 48 months. It was not clear whether establishment failed to occur because the strains were unsuitable, the general environment was inappropriate or A. polynesiensis was present in such numbers that A. albopictus rarely succeeded in mating with its own species. KW - biological control KW - control KW - disease transmission KW - disease vectors KW - filariids KW - helminths KW - insect control KW - mosquito nets KW - natural enemies KW - parasites KW - transmission KW - French Polynesia KW - Aedes albopictus KW - Aedes polynesiensis KW - Culicidae KW - Diptera KW - Insects KW - Nematoda KW - Wuchereria bancrofti KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - France overseas KW - Polynesia KW - Oceania KW - Pacific Islands KW - Asian tiger mosquito KW - biocontrol KW - competition KW - competitive displacement KW - displacement by non-vector KW - human filariae KW - mosquitoes KW - nematodes KW - not infective KW - parasitic worms KW - Secernentea KW - Spirurida KW - Taiaro KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Biological Control (HH100) KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Behaviour (LL300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770540098&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serological studies on the epidemiology of sandfly fever in the Old World. AU - Tesh, R. B. AU - Saidi, S. AU - Gajdamovic, S. Ja. AU - Rodhain, F. AU - Vesenjak-Hirjan, J. JO - Bulletin of the World Health Organization JF - Bulletin of the World Health Organization Y1 - 1976/// VL - 54 IS - 6 SP - 663 EP - 674 SN - 0042-9686 AD - Tesh, R. B.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, PO Box 1680, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19770547071. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Selected human sera from 59 different localities in Africa, the Mediterranean littoral, eastern Europe and Asia were examined by plaque reduction neutralisation test against 8 sandfly fever serotypes (Sicilian, Naples, Arumowot, Sudan 754-61, Karimabad, Salehabad, Gordil and Saint Floris) known to occur in the Old World. Results of these studies provide new information on the geographical distribution and prevalence of human infection with each of the viruses. Specific neutralising antibodies were detected against all of the agents except Salehabad. Antibodies to Naples and Sicilian serotypes were encountered most frequently and had the widest geographical range; moreover, they were found only in areas where Phlebotomus papatasi (Scop.) occurs. Age-specific antibody rates for several of the viruses are presented. These data and the epidemiology of sandfly fever are discussed. KW - antibodies KW - disease transmission KW - transmission KW - Diptera KW - man KW - Phlebotominae KW - Phlebotomus papatasi KW - Psychodidae KW - Sandfly fever Naples virus KW - viruses KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - Phlebovirus KW - Bunyaviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Old World KW - sandfly fever viruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770547071&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An in vitro assay for T cell immunity to malaria in mice. AU - Weinbaum, F. I. AU - Evans, C. B. AU - Tigelaar, R. E. JO - Journal of Immunology JF - Journal of Immunology Y1 - 1976/// VL - 116 IS - 5 SP - 1280 EP - 1283 AD - Weinbaum, F. I.: Lab. of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19762500813. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology N2 - After infection with a nonlethal strain of murine malaria (17 XNL Plasmodium berghei yoelii), BALB/c mice are then resistant to a lethal strain (17XL P. b. yoelii). BALB/c mice were infected with 17 XNL, and challenged 3 weeks later, after clearing their parasitaemias, with 17XL. 3 weeks thereafter, spleen cells from such immune animals were used to define an early-peaking T-dependent (anti-thymus sensitive) antigen-specific proliferative response when incubated in vitro with 17XL-infected red blood cells, or a saline-soluble 17XL antigen preparation. T-dependent responsiveness of spleen cells from uninoculated controls to the 17XL antigen preparation was also observed, but demonstrated a much different (delayed) kinetics from that observed with immune cells. [AS] KW - immunology KW - parasites KW - MICE KW - Plasmodium berghei KW - protozoa KW - Rodents KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - T cell immunity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500813&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Atypical radiographic features in Pneumocystis carinii pneumonia. AU - Doppman, J. L. JO - National Cancer Institute Monograph JF - National Cancer Institute Monograph Y1 - 1976/// IS - 43 SP - 89 EP - 95 AD - Doppman, J. L.: National Institutes of Health, Public Health Service, Dep. of Health, Education, and Welfare, Bethesda, Md. 20014, USA. N1 - Accession Number: 19780848061. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology N2 - In 30 patients with confirmed Pneumocystis pneumonia the typical radiographic picture was one of acute bilateral perihilar and basilar infiltrate progressing to diffuse alveolar consolidation within 3 to 5 days, unassociated with adenopathy or pleural changes. In some patients however various atypical findings were present on some occasions. KW - diagnosis KW - parasites KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - diagnosis by X-rays KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780848061&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The epidemiology of the relapsing fevers. AU - Burgdorfer, W. T2 - R.C.Johnson (Editor). The biology of parasitic spirochetes. JO - R.C.Johnson (Editor). The biology of parasitic spirochetes. JF - R.C.Johnson (Editor). The biology of parasitic spirochetes. Y1 - 1976/// SP - 191 EP - 200 CY - New York; USA PB - Academic Press, Inc. AD - Burgdorfer, W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, USA. N1 - Accession Number: 19770545646. Publication Type: Miscellaneous. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology N2 - An outline is presented of the epidemiological characteristics of louse-borne (epidemic) relapsing fever, caused by Borrelia recurrentis, which is transmitted by Pediculus humanus humanus L. and of tick-borne (endemic) relapsing fevers caused by spirochaetes transmitted by Ornithodoros spp. The current world distribution and status of these diseases is reviewed and discussed, and information on vectors, aetiological agents, animal hosts and distribution is summarised in a table. KW - disease transmission KW - epidemiology KW - relapsing fever KW - transmission KW - Acari KW - Anoplura KW - Borrelia recurrentis KW - Ornithodoros KW - Pediculus humanus KW - Spirochaetales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Phthiraptera KW - insects KW - Hexapoda KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Argasidae KW - Metastigmata KW - Acari KW - Pediculus KW - Pediculidae KW - Anoplura KW - Pediculus humanus KW - bacterium KW - body louse KW - Pediculus humanus humanus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770545646&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A simple technique for the detection of dengue antigen in mosquitoes by immunofluorescence. AU - Kuberski, T. T. AU - Rosen, L. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1977/// VL - 26 IS - 3 SP - 533 EP - 537 SN - 0002-9637 AD - Kuberski, T. T.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19770547170. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Dengue antigen was demonstrated by a direct fluorescent antibody technique in simple head squashes of both males and females of Aedes albopictus (Skuse) infected with any of the 4 dengue serotypes. Dengue viruses can be isolated rapidly and simply by combining this technique with that of parenteral inoculation of mosquitoes with test material. KW - detection KW - IMMUNOFLUORESCENCE KW - mosquito nets KW - Aedes albopictus KW - Culicidae KW - dengue virus KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Asian tiger mosquito KW - fluorescent antibody technique KW - IFAT KW - mosquitoes KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770547170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of dengue viruses using complement fixing antigen produced in mosquitoes. AU - Kuberski, T. T. AU - Rosen, L. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1977/// VL - 26 IS - 3 SP - 538 EP - 543 SN - 0002-9637 AD - Kuberski, T. T.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institutes of Health, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19770547171. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Complement fixing antigen produced in males of Aedes albopictus (Skuse) infected with dengue viruses was used in conjunction with prototype immune mouse ascitic fluids to identify these viruses as to serotype. KW - complement fixation tests KW - detection KW - mosquito nets KW - Aedes albopictus KW - Culicidae KW - dengue virus KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Asian tiger mosquito KW - mosquitoes KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770547171&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Control of antennal hair erection in male mosquitoes. AU - Nijhout, H. F. JO - Biological Bulletin JF - Biological Bulletin Y1 - 1977/// VL - 153 IS - 3 SP - 591 EP - 603 SN - 0006-3185 AD - Nijhout, H. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19780551124. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The long fibrillae, or hairs, on the antennae of male mosquitoes play an essential role in the detection of female flight sound, the sole sexual attractant. In Anopheles stephensi List., as in many other genera and species, these long hairs are recumbent on the shaft of the antenna during the daytime and become briefly erect at dusk, at the time when swarming and mating activity occurs. Evidence is presented from studies in the USA that the erection of the antennal hairs is under direct nervous control. Isolated antennae can be induced to erect their hairs only in the presence of alpha -adrenergic agonists and this response is blocked in the presence of the alpha -adrenergic blocking drug phentolamine. Thus, a cell surface receptor, resembling the vertebrate alpha -adrenergic receptor probably mediates the response to the natural neurotransmitter. The action of alpha -adrenergic drugs is mimicked by cyclic nucleotides and also by theophylline. KW - antennae KW - mosquito nets KW - Anopheles stephensi KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - blocking erection of antennal hairs KW - mosquitoes KW - nervous control of erection of hairs KW - phentolamine KW - Other Control Measures (HH700) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780551124&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - A critique of merozoite and sporozoite vaccines in malaria. AU - Miller, L. H. A2 - Miller, L.H. A2 - Pino, J.A. A2 - McKelvey, J.J., Jr. T2 - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93). JO - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93). JF - Immunity to blood parasites of animals and man. (Advances in experimental medicine and biology, Volume 93). Y1 - 1977/// SP - 113 EP - 120 CY - New York, USA & London; UK PB - Plenum Press. AD - Miller, L. H.: Lab. of Parasit. Dis., National Inst. of Allergy & Infectious Dis., National Institutes of Health, Bethesda, MD 20014, USA. N1 - Accession Number: 19780847790. Publication Type: Miscellaneous. Language: English. Subject Subsets: Protozoology N2 - The relative merits of sporozoite and merozoite vaccines against malaria are discussed. Merozoite vaccine has been studied only for a short while, only in relation to Plasmodium knowlesi in monkeys, and challenge has been by blood forms only. Sporozoite vaccine has been successful after sporozoite challenge in avian, rodent, monkey and human malaria. The development of a merozoite vaccine seems the more attainable goal but this should not deter research on sporozoite immunity and other approaches. KW - immunology KW - parasites KW - monkeys KW - Plasmodium KW - Plasmodium knowlesi KW - Primates KW - protozoa KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium KW - Haemosporida KW - immunization with merozoites KW - immunization with sporozoites immunology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780847790&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical differences between serotypes of Cryptococcus neoformans. AU - Bennett, J. E. AU - Kwon-Chung, K. J. AU - Theodore, T. S. JO - Sabouraudia JF - Sabouraudia Y1 - 1978/// VL - 16 IS - 3 SP - 167 EP - 174 AD - Bennett, J. E.: Nat. Inst. Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20014, USA. N1 - Accession Number: 19781348932. Publication Type: Journal Article. Language: English. Language of Summary: Spanish. Number of References: 15 ref. Registry Number: 60-72-5, 110-17-8, 6915-15-7, 110-15-6. Subject Subsets: Medical & Veterinary Mycology; Veterinary Science N2 - Uptake of radiolabelled l-malic acid was approximately tenfold greater in serotype B and C than in A and D isolates. Assimilation of l-malic, fumaric and succinic acids also distinguished serotypes B and C from A and D. Greening of Guizotia seed agar occurred with 18 of 32 serotype B and C but in none of 91 serotype A or D isolates. The one property not following the same line of division was relatively slow creatinine assimilation, which distinguished type A alone. KW - biochemistry KW - Creatinine KW - Fumaric acid KW - Malic acid KW - poultry KW - poultry diseases KW - Succinic acid KW - Cryptococcus (Fungi) KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - assimilation of Krebs cycle intermediates KW - Cryptococcus (Deuteromycotina) KW - differences between serotypes KW - domesticated birds KW - fungus KW - malate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781348932&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diuresis after a bloodmeal in female Anopheles freeborni. AU - Nijhout, H. F. AU - Carrow, G. M. JO - Journal of Insect Physiology JF - Journal of Insect Physiology Y1 - 1978/// VL - 24 IS - 4 SP - 293 EP - 298 SN - 0022-1910 AD - Nijhout, H. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19780556494. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Females of Anopheles freeborni Aitken discharged urine rapidly and copiously for a brief time after taking a meal of blood. This diuresis began immediately on cessation of feeding and continued for about 30 min at a constant rate. A decline in this rate followed, and diuresis was completed 50 min after feeding. This time-course of diuresis was independent of the size of the meal; diuresis after large meals occurred at a higher rate, not over a longer time, than diuresis after small meals. Heat-stable and saline-soluble substances that induce rapid excretion by isolated Malpighian tubules can be extracted from the head and thoracic nervous system, suggesting the presence of a neurosecretory diuretic hormone similar to that found in other blood-sucking insects. Decapitation or section of the ventral nerve cord abolished the rapid phase of diuresis after a blood-meal. Therefore, in analogy to the situation in Glossina, the head is required either as the source of a diuretic hormone or as link in the pathway that stimulates its release. KW - diuresis KW - mosquito nets KW - Anopheles freeborni KW - Culicidae KW - Diptera KW - Glossina KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Glossinidae KW - blood-feeding KW - mosquitoes KW - Other Control Measures (HH700) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780556494&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clonal growth of Entamoeba histolytica and other species of Entamoeba in agar. AU - Gillin, F. D. AU - Diamond, L. S. JO - Journal of Protozoology JF - Journal of Protozoology Y1 - 1978/// VL - 25 IS - 4 SP - 539 EP - 543 SN - 0022-3921 AD - Gillin, F. D.: National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19780859070. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology N2 - This is the first description of a method for growing axenized Entamoeba histolytica as colonies from single cells in agar suspension. Factors affecting the efficiency of colony formation included unknown characteristics of the amoebal strain, age of cells used, and the type and concentration of agar employed. Colony formation was dependent upon filling deep vessels (culture tubes or tissue culture flasks) with agar, probably to maintain reduced oxygen tension, and upon solidifying the agar rapidly at 0 deg C. In a study with the drug metronidazole, the agar colony method was useful for quantifying cell viability. 11 of 12 E. histolytica strains tested, as well as one E. terrapinae, one E. barreti and 3 E. invadens strains formed colonies in agar suspension. E. histolytica-like amoebae (Laredo type) and E. moshkovskii formed only tiny colonies in agar. [AS] KW - parasites KW - Entamoeba KW - Entamoeba histolytica KW - protozoa KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - clonal culture KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780859070&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Membrane potential dependent binding of scorpion toxin to the action potential sodium ionophore. Studies with a 3-(4-hydroxy 3-[125I] iodophenyl) propionyl derivative. AU - Ray, R. AU - Catterall, W. A. JO - Journal of Neurochemistry JF - Journal of Neurochemistry Y1 - 1978/// VL - 31 SP - 397 EP - 407 SN - 0022-3042 AD - Ray, R.: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19790566964. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A polypeptide toxin purified 80-fold from the venom of the scorpion Leiurus quinquestriatus (Hemprich & Ehrenberg) enhanced activation of the action potential Na+ ionophore by the alkaloid neurotoxins veratridine, batrachotoxin and aconitine in electrically excitable neuroblastoma cells. Studies suggested that scorpion toxin binds specificially to a regulatory component (gate) of the Na+ ionophore, the conformation of which is dependent on membrane potential. KW - peptides KW - toxins KW - venoms KW - Arachnida KW - Leiurus quinquestriatus KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leiurus KW - Buthidae KW - Scorpiones KW - Arachnida KW - venom KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790566964&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. AU - Diamond, L. S. AU - Harlow, D. R. AU - Cunnick, C. C. JO - Transactions of the Royal Society of Tropical Medicine and Hygiene JF - Transactions of the Royal Society of Tropical Medicine and Hygiene Y1 - 1978/// VL - 72 IS - 4 SP - 431 EP - 432 SN - 0035-9203 AD - Diamond, L. S.: National Institutes of Health, Bethesda, MD, 20014, USA. N1 - Accession Number: 19780849994. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology N2 - The preparation of a new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba spp. is described. TYI-S-33 (Trypticase, yeast extract, iron-serum) consists of a nutrient broth (TYI), a vitamin-Tween 80 mixture, and bovine serum. The medium is sensitive to light and is used within 96 hours after preparation for growth assays and within 10 days for maintenance of stock cultures. Biosate, a peptone mixture consisting of 2 parts Trypticase:one part yeast extract (by weight) can be substituted for the peptone components of TYI-S-33. The medium is then designated BI-S-33. The 2 forms of the medium can be used interchangeably. A few E. histolytica strains grew poorly, if at all, in the presence of 10% serum; 15% serum was necessary to culture these strains. Compared with TP-S-1 the new medium requires smaller inocula to maintain the cultures, the resulting yields are greater, growth is more uniform, and in the case of E. histolytica, the generation time has been reduced approximately one third. KW - culture KW - parasites KW - Entamoeba KW - Entamoeba histolytica KW - protozoa KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780849994&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transovarial transmission of Japanese encephalitis virus by mosquitoes. AU - Rosen, L. AU - Tesh, R. B. AU - Lien, J. C. AU - Cross, J. H. JO - Science, USA JF - Science, USA Y1 - 1978/// VL - 199 IS - 4331 SP - 909 EP - 911 AD - Rosen, L.: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19780554691. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science N2 - Females of Aedes albopictus (Skuse) and A. togoi (Theo.) infected with Japanese encephalitis virus either by intrathoracic inoculation or by ingestion of a virus-sucrose-erythrocyte mixture transmitted the virus to a small percentage of their F1 progeny. Adult F1 females of A. albopictus thus infected transmitted the virus in turn to newly hatched chickens by feeding on them. KW - chicks KW - Disease transmission KW - Japanese encephalitis KW - mosquito nets KW - poultry KW - transovarial transmission KW - vectors KW - Zoonoses KW - Aedes KW - Aedes albopictus KW - Aedes togoi KW - Culicidae KW - Diptera KW - fowls KW - Japanese encephalitis virus KW - Man KW - viruses KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Aedes KW - Gallus gallus KW - Gallus KW - Phasianidae KW - Galliformes KW - birds KW - vertebrates KW - Chordata KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - Asian tiger mosquito KW - chickens KW - domesticated birds KW - mosquitoes KW - Ochlerotatus KW - Ochlerotatus togoi KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780554691&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Observations on the subgenus Argas (Ixodoidea: Argasidae: Argas). 16. Argas (A.) moreli, new species, and keys to Neotropical species of the subgenus. AU - Keirans, J. E. AU - Hoogstraal, H. AU - Clifford, C. M. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1979/// VL - 15 IS - 3 SP - 246 EP - 252 SN - 0022-2585 AD - Keirans, J. E.: USDHEW, PHS, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA. N1 - Accession Number: 19790563593. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Argas moreli sp. n., is described from males, females, and nymphs from a house, and from unknown situations, in Junin and Arequipa Provinces, at 4150 and 2329 m in altitude, in Peru. Probable hosts are wild birds, domestic fowls and man. The peripheral integument of this distinctive species lacks the cells similar to those of A. persicus (Oken) seen in several other Neotropical species of the subgenus Argas, but regularly spaced, deep sutures bounding a broad peripheral area with a small setiferous pit form 'pseudo persicus-like cells'. This species may represent a phylogenetic gradient between Argas species lacking persicus-like cells (all faunal regions, including Neotropical) and those having these cells (Neotropical only). Ticks identified as A. persicus, but likely to represent A. moreli, have been reported to bite man in Arequipa and to cause a severe pruritus. KW - descriptions KW - dwellings KW - hosts KW - integument KW - new species KW - pruritus KW - Peru KW - Acari KW - Argas persicus KW - man KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Argas KW - Argasidae KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Andean Group KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - South America KW - Argas moreli KW - fowl tick KW - itchiness KW - itching KW - moreli, Argas KW - pruritus caused KW - tegument KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790563593&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fluorescent antibody studies on the development of dengue-2 virus in Aedes albopictus (Diptera: Culicidae). AU - Kuberski, T. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1979/// VL - 16 IS - 4 SP - 343 EP - 349 SN - 0022-2585 AD - Kuberski, T.: Pacific Research Station, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806, USA. N1 - Accession Number: 19800569862. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - In the laboratory in Honolulu, Hawaii, females of Aedes albopictus (Skuse) were fed with a suspension of sucrose, human blood cells and dengue-2 virus; groups of these mosquitoes were collected on alternate days for 3 weeks and tested by the fluorescent-antibody technique with a view to demonstrating the development of dengue virus. Dengue virus antigen was found to be limited to the cells of the posterior mid-gut 2 days after the infective blood-meal, but the proventriculus, fat-body, nervous system, ovariole sheath and portions of the salivary glands displayed fluorescence 6 days after infection. From the sixth day onwards, dengue antigen was found disseminated in numerous tissues, but the amount of demonstrable antigen and the intensity of fluorescence was most marked in structures of the nervous system. Viral antigen was not consistently or uniformly demonstrated in the salivary glands, and the type of fluorescence was qualitatively different from that of other infected tissues. Dengue antigen was not demonstrated in the eggs or spermathecae. KW - detection KW - IMMUNOFLUORESCENCE KW - mosquito nets KW - Aedes albopictus KW - Culicidae KW - dengue virus KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Asian tiger mosquito KW - fluorescent antibody technique KW - IFAT KW - localisation KW - mosquitoes KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800569862&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Screening system for Egyptian plants with potential anti-tumour activity. AU - El-Merzabani, M. M. AU - El-Aaser, A. A. AU - Attia, M. A. AU - El-Duweini, A. K. AU - Ghazal, A. M. JO - Planta Medica JF - Planta Medica Y1 - 1979/// VL - 36 IS - 2 SP - 150 EP - 155 SN - 0032-0943 AD - El-Merzabani, M. M.: National Cancer Institute, Cairo, Egypt. N1 - Accession Number: 19800381235. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Horticultural Science N2 - Eight species representing 8 genera from 8 families were screened. Hedera helix, Prosopis juliflora and Catharanthus roseus showed cytotoxic effects. KW - medicinal plants KW - medicinal properties KW - surveys KW - Egypt KW - Catharanthus roseus KW - Hedera helix KW - Prosopis juliflora KW - Catharanthus KW - Apocynaceae KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Hedera KW - Araliaceae KW - Apiales KW - Prosopis KW - Mimosoideae KW - Fabaceae KW - Fabales KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - Araliales KW - drug plants KW - ivy KW - medicinal herbs KW - Misr KW - officinal plants KW - Plant Science (General) (FF000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800381235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Screening system for Egyptian plants with potential anti-tumour activity. AU - Merzabani, M. M. El- AU - Aaser, A. A. El- AU - Attia, M. A. AU - Duweini, A. K. El- AU - Ghazal, A. M. JO - Planta Medica JF - Planta Medica Y1 - 1979/// VL - 36 IS - 2 SP - 150 EP - 155 SN - 0032-0943 AD - Merzabani, M. M. El-: National Cancer Institute, Cairo, Egypt. N1 - Accession Number: 19802605105. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - Eight species representing 8 genera from 8 families were screened. Hedera helix, Prosopis juliflora and Catharanthus roseus showed cytotoxic effects. KW - arid zones KW - medicinal plants KW - surveys KW - Egypt KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - arid regions KW - drug plants KW - medicinal herbs KW - Misr KW - officinal plants KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Other Sciences (ZZ000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19802605105&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Entamoeba histolytica: genetic control of susceptibility in chicken eggs. AU - Jaoum, K. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1979/// VL - 47 IS - 1 SP - 54 EP - 64 SN - 0014-4894 AD - Jaoum, K. C.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19790143864. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Animal Breeding N2 - Five strains of axenised Entamoeba histolytica were established in eggs from White Leghorn fowls of several strains. The eggs of outbred and inbred fowls differed in the proportion of embryos from which the E. histolytica strains were recovered, and there were variations in the number of trophozoites recovered from individual positive eggs. It was possible to find individual, single-mated hens that laid only uniformly susceptible or resistant eggs. Susceptibility and resistance to E. histolytica could be demonstrated in embryonated eggs derived from outbred heterogeneous and highly inbred fowls, but eggs from a genetically stable source were relatively constant in the distribution of susceptible and resistant embryos. The results obtained suggested that susceptibility is a dominant trait, and may be linked with resistance to subgroup A avian leucosis viruses. KW - disease resistance KW - embryos KW - genetic control KW - genotypes KW - Entamoeba histolytica KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - resistance to disease KW - resistance to Entamoeba histolytica KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790143864&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: exflagellation stimulated by a mosquito factor. AU - Nijhout, M. M. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1979/// VL - 48 IS - 1 SP - 75 EP - 80 SN - 0014-4894 AD - Nijhout, M. M.: National Institutes of Health, Bethesda, Maryland 20014, USA. N1 - Accession Number: 19790862222. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology; Veterinary Science N2 - Midgut tissue from Aedes aegypti stimulated exflagellation of gametocytes of Plasmodium gallinaceum in the absence of bicarbonate, a factor necessary for in vitro exflagellation. Exflagellation was also stimulated when washed infected red cells in a buffered saline (pH 7.4) not containing bicarbonate were introduced into the midgut by enema. The exflagellation-stimulating activity was neither sex nor species specific. Preparations of a mosquito exflagellation factor (MEF) were obtained without tisse disruption by collecting the fluid excreted by Anopheles stephensi females while they were feeding on warm saline. MEF was dialyzable and stable to boiling and decarbonation. Thus, MEF is not bicarbonate. [AS] KW - Gametes KW - in vitro KW - parasites KW - physiology KW - Aedes KW - Culicidae KW - Plasmodium KW - Plasmodium gallinaceum KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - exflagellation & mosquito extract KW - Haemosporida KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790862222&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The ultrastructural aspects of Giardia. AU - Sheffield, H. G. A2 - : Jakubowski, W. A2 - Hoff, J.C. T2 - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA). JO - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA). JF - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA). Y1 - 1979/// SP - 9 EP - 20 CY - Cincinnati, Ohio; USA PB - US Environmental Protection Agency. AD - Sheffield, H. G.: National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19790863699. Publication Type: Miscellaneous. Language: English. Subject Subsets: Protozoology N2 - The morphology of the trophozoite and cyst of Giardia lamblia as determined by transmission and scanning electron microscopy is reviewed. KW - parasites KW - reviews KW - ultrastructure KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Giardia lamblia KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790863699&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Extensive myiasis from tumbu fly larvae in Ghana, West Africa. AU - Biggar, R. J. AU - Morrow, H. AU - Morrow, R. H. JO - Clinical Pediatrics JF - Clinical Pediatrics Y1 - 1980/// VL - 19 IS - 3 SP - 231 EP - 232 SN - 0009-9228 AD - Biggar, R. J.: National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19800579125. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The infestation of a previously healthy 14-month-old girl with 94 larvae of Cordylobia anthropophaga (blanch. & Berenger-Feraud) is described. Treatment involved application of an occlusive ointment over the hole in each lesion and extrusion of the larva by gentle pressure. KW - control KW - myiasis KW - removal KW - Ghana KW - Cordylobia anthropophaga KW - Diptera KW - man KW - Cordylobia KW - Calliphoridae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800579125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Physiological changes governing the onset of sexual receptivity in male mosquitoes. AU - Beach, R. JO - Journal of Insect Physiology JF - Journal of Insect Physiology Y1 - 1980/// VL - 26 IS - 4 SP - 245 EP - 252 SN - 0022-1910 AD - Beach, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19800574803. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 5289-74-7. Subject Subsets: Medical & Veterinary Entomology N2 - The effectors that erect antennal hairs in males of Aedes aegypti (L.) and Anopheles freeborni Aitken are shown to be unresponsive to the neurotransmitter that triggers antennal hair erection until 12-24 h after emergence. The unresponsive period can be prolonged by transfusion of haemolymph from newly-emerged males, or by injection of 20-hydroxyecdysone. This suggests that the hormone persisting after the metamorphosis from pupa to adult affects the duration of the post-emergence delay in antennal hair erection and is indirectly responsible for timing the onset of sexual receptivity in male mosquitoes. KW - ecdysterone KW - mosquito nets KW - Aedes aegypti KW - Anopheles freeborni KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - delaying onset of male sexual receptivity KW - factors governing onset KW - mosquitoes KW - sexual receptivity KW - Other Control Measures (HH700) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800574803&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ovarian control of blood meal retention in the mosquito Anopheles freeborni. AU - Rosenberg, R. JO - Journal of Insect Physiology JF - Journal of Insect Physiology Y1 - 1980/// VL - 26 IS - 7 SP - 477 EP - 480 SN - 0022-1910 AD - Rosenberg, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19800577901. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 5289-74-7. Subject Subsets: Medical & Veterinary Entomology N2 - Females of Anopheles freeborni Aitken began to excrete the haem-containing residue of a blood-meal about the time their eggs matured, 40-45 h after feeding. Ovariectomised females began to defaecate 15 h prematurely, while ovariectomised females treated with 20-hydroxyecdysone retained blood-meals longer, proportional to dose, than did untreated females. It is concluded that the production of ecdysteroids by the ovary initiates a mechanism for retention of the blood-meal in the mosquito. KW - blood-meals KW - ecdysterone KW - mosquito nets KW - Anopheles freeborni KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - mosquitoes KW - ovarian regulation of retention KW - retention of blood-meal KW - Other Control Measures (HH700) KW - Animal Reproduction and Development (LL210) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800577901&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sexual transmission of spotted fever group rickettsiae by infected male ticks: detection of rickettsiae in immature spermatozoa of Ixodes ricinus. AU - Hayes, S. F. AU - Burgdorfer, W. AU - Aeschlimann, A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1980/// VL - 27 IS - 2 SP - 638 EP - 642 SN - 0019-9567 AD - Hayes, S. F.: National Institute of Allergy and Infectious Diseases, Epidemology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19810582502. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Evidence from electron microscopy showed that the newly described 'Swiss agent', a spotted-fever group rickettsia, is incorporated into the reproductive cells of its male tick vector, Ixodes ricinus (L.). Rickettsiae were found in spermotogonia, spermatocytes, and maturing spermatids. The potential significance of these observations is briefly discussed in relation to published data on sexual transmission of rickettsiae by ticks. KW - sexual transmission KW - Acari KW - Ixodes ricinus KW - viruses KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Microtabiotes KW - spotted-fever rickettsiae KW - venereal transmission KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810582502&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission of Plasmodium vivax from Vietnam by four different anophelines. AU - Collins, W. E. AU - Contacos, P. G. AU - Chin, W. AU - Jeter, M. H. AU - Briesch, P. E. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1980/// VL - 29 IS - 3 SP - 473 EP - 475 SN - 0002-9637 AD - Collins, W. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19800574758. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Infections of the SV-I strain of Plasmodium vivax from Vietnam were transmitted via the bites of infected Anopheles stephensi List., A. maculatus Theo. and A. balabacensis balabacensis Baisas. Infected salivary glands were also found in A. freeborni Aitken. In 18 successful transmissions, prepatent periods ranged from 10-17 days. Four black volunteers failed to develop infections even though they were fed upon by heavily infected A. maculatus and A. b. balabacensis.<new para>ADDITIONAL ABSTRACT:<new para>Plasmodium vivax strain SV-1 from Vietnam was transmitted experimentally by Anopheles stephensi, A. maculatus and A. balabacensis balabacensis. Infected salivary glands were also found in A. freeborni mosquitoes. Prepatent periods in 18 transmissions ranged from 10 to 17 days. 4 Black volunteers resisted infection. KW - disease transmission KW - epidemiology KW - experimental infection KW - infectivity KW - mosquito nets KW - parasites KW - transmission KW - Anopheles balabacensis KW - Anopheles freeborni KW - Anopheles maculatus KW - Anopheles stephensi KW - Apicomplexa KW - Culicidae KW - Diptera KW - insects KW - Plasmodium vivax KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Anopheles balabacensis KW - Anopheles balabacensis balabacensis KW - experimental transmission KW - mosquitoes KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800574758&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ornithodoros (Alectorobius) amblus (Acarina: Ixodoidea: Argasidae): identity, marine bird and human hosts, virus infections, and distribution in Peru. AU - Clifford, C. M. AU - Hoogstraal, H. AU - Radovsky, F. J. AU - Stiller, D. AU - Keirans, J. E. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1980/// VL - 66 IS - 2 SP - 312 EP - 323 SN - 0022-3395 AD - Clifford, C. M.: National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19800574985. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Ornithodoros amblus Chamberlain was inadequately described from an adult of unstated sex from Peru. As part of a continuing attempt to stabilise species concepts in the group of O. capensis Neum., the adults of both sexes are here described, together with the nymph and larva, and criteria are presented for differentiating these stages from those of other members of the group in the Western Hemisphere. Examples were collected from 13 localities on the Pacific coast and on offshore islands of Peru. The bird hosts were species that do not migrate over long distances. The life-cycle of the tick was found to be typical of the O. capensis group; nymphs in the first instar did not necessarily feed. Man is eagerly attacked by O. amblus, and the consequences are severe inflammation and extremely intense pruritus; it is possible that more severe illness may also be caused by the attack. The viruses isolated from the ticks were Punta Salinas (Hughes serogroup) and Huacho (of the genus Orbivirus, Kemerovo subgroup, of the Reoviridae). Dense tick populations cause breeding birds to desert numerous nests, and the tick is thus economically important to the Peruvian guano industry. Spiders and lizards are thought to afford a considerable degree of control of O. amblus. KW - biology KW - bites KW - descriptions KW - groups KW - inflammation KW - natural enemies KW - predators KW - prey KW - pruritus KW - Peru KW - Acari KW - Araneae KW - arthropods KW - birds KW - Carios capensis KW - lizards KW - man KW - viruses KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - vertebrates KW - Chordata KW - Carios KW - Argasidae KW - Metastigmata KW - Acari KW - Sauria KW - reptiles KW - Homo KW - Hominidae KW - Primates KW - mammals KW - Ornithodoros KW - Andean Group KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - South America KW - cape tampan KW - Huacho virus KW - itchiness KW - itching KW - Ornithodoros amblus KW - Ornithodoros capensis KW - Punta Salinas virus KW - seabird soft tick KW - spiders KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800574985&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Tularemia. AU - Bell, J. F. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 161 EP - 193 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Bell, J. F.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590100. Publication Type: Miscellaneous. Language: English. Number of References: 188 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science N2 - The author reviews the isolation and identification of the causal agent (Francisella tularensis) of tularaemia; the classification, morphology, culture and virulence of the organism; the clinical characteristics of the disease it causes in man and other animals; its epidemiology (including a list of mammal species known to be susceptible to infection); and transmission. Transmission is effected in various ways and the confirmed or assumed involvement of various groups of arthropods (including Diptera, Siphonaptera and Anoplura, but especially ticks) is discussed. KW - disease transmission KW - disease vectors KW - hosts KW - reviews KW - transmission KW - tularaemia KW - vectors KW - Wild animals KW - Zoonoses KW - Anoplura KW - Diptera KW - Francisella KW - Francisella tularensis KW - METASTIGMATA KW - Siphonaptera KW - Phthiraptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Francisellaceae KW - Thiotrichales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Francisella KW - Acari KW - Arachnida KW - bacterium KW - Ixodoidea KW - Schizomycetes KW - tularemia KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biological Resources (Animal) (PP710) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The spotted fever-group diseases. AU - Burgdorfer, W. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 279 EP - 300 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Burgdorfer, W.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590101. Publication Type: Miscellaneous. Language: English. Number of References: 119 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Information is given on the causal agent, epidemiology, transmission, occurrence in man or other animals or both, clinical manifestations and world distribution of diseases of the spotted-fever group, caused by Rickettsia spp. These diseases include Rocky Mountain spotted fever, North Asian tick typhus, boutonneuse fever and Queensland tick typhus, all of which are transmitted by ticks, and rickettsial pox, which is transmitted by the mite Liponyssoides sanguineus (Hirst). The diagnosis, treatment, prevention and control of the diseases (including control of the arthropod vectors) are also briefly discussed. KW - disease transmission KW - Mediterranean spotted fever KW - reviews KW - Rocky Mountain spotted fever KW - transmission KW - man KW - METASTIGMATA KW - Rickettsia KW - Rickettsiales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Liponyssoides KW - Dermanyssidae KW - Mesostigmata KW - mites KW - bacterium KW - boutonneuse fever KW - Ixodoidea KW - Liponyssoides sanguineus KW - Rickettsiaceae infections KW - rickettsial pox KW - tick typhus, North Asian KW - tick typhus, Queensland KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590101&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Scrub typhus. AU - Philip, R. N. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 303 EP - 315 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Philip, R. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590102. Publication Type: Miscellaneous. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology N2 - In this review of scrub typhus, caused by Rickettsia tsutsugamushi, the topics dealt with include the morphology and life-cycle of R. tsutsugamushi, its hosts (mites of the genus Leptotrombidium and vertebrates, especially small mammals), the spread and epidemiology of the disease, its diagnosis and its prevention and control, particularly the use of repellents to provide protection from the mites and of chemical compounds to kill the mites. KW - disease transmission KW - disease vectors KW - hosts KW - reviews KW - scrub typhus KW - small mammals KW - transmission KW - vectors KW - Leptotrombidium KW - Orientia tsutsugamushi KW - Rickettsiales KW - Trombiculidae KW - Prostigmata KW - mites KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Orientia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - tsutsugamushi disease KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590102&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Typhus-group rickettsiae. AU - Philip, R. N. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 317 EP - 335 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Philip, R. N.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590103. Publication Type: Miscellaneous. Language: English. Number of References: 111 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Information is presented on the 3 species of Rickettsia that comprise the typhus group: R. prowazekii, the agent of epidemic typhus, which is transmitted from man to man by Pediculus humanus humanus L.; R. typhi, the agent of murine typhus, the main vector of which is Xenopsylla cheopis (Roths.); and R. canada, which has been isolated from Haemaphysalis leporispalustris (Pack.) and is related to rickettsiae of the typhus group but has not yet been confirmed as pathogenic to man. KW - disease transmission KW - murine typhus KW - reviews KW - transmission KW - Haemaphysalis leporispalustris KW - man KW - Pediculus humanus KW - Rickettsia canadensis KW - Rickettsia prowazekii KW - Rickettsia typhi KW - Rickettsiales KW - Xenopsylla cheopis KW - Haemaphysalis KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Pediculus KW - Pediculidae KW - Anoplura KW - Phthiraptera KW - insects KW - Hexapoda KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Xenopsylla KW - Pulicidae KW - Siphonaptera KW - bacterium KW - body louse KW - flea-borne typhus KW - Oriental rat flea KW - Rickettsia canada KW - typhus, epidemic louse-borne KW - typhus-group rickettsiae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590103&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Q fever. AU - Stoenner, H. G. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 337 EP - 352 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Stoenner, H. G.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590104. Publication Type: Miscellaneous. Language: English. Number of References: 89 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science N2 - Coxiella burnetii, the causal agent of Q fever was originally isolated from Dermacentor andersoni Stiles but has since been found naturally infecting 9 species of Dermacentor, 9 of Rhipicephalus, 10 of Haemaphysalis, 10 of Ixodes, 15 of Hyalomma, 4 of Amblyomma, 7 of Ornithodoros, 2 of Argas, 2 of Boophilus and Otobius megnini (Duges). Its presence has also been demonstrated in 12 species of mites and at least 3 species of fleas. The precise role of these arthropods in the epizootiology of Q fever among wildlife has not been clarified. The epidemiology of the disease, the species in which it occurs, its distribution, diagnosis, treatment prevention are reviewed. KW - disease transmission KW - disease vectors KW - hosts KW - Q fever KW - reviews KW - transmission KW - vectors KW - Amblyomma KW - Argas KW - Coxiella KW - Coxiella burnetii KW - Dermacentor KW - Dermacentor andersoni KW - Haemaphysalis KW - Hyalomma KW - Ixodes KW - mites KW - Ornithodoros KW - Otobius megnini KW - Rhipicephalus KW - Rickettsiales KW - Siphonaptera KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Argasidae KW - Coxiellaceae KW - Legionellales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Coxiella KW - Dermacentor KW - Otobius KW - Alphaproteobacteria KW - insects KW - Hexapoda KW - abattoir fever KW - bacterium KW - Balkan grippe KW - Boophilus KW - Derrick-Burnet disease KW - ear tick KW - Nine Mile fever KW - pneumorickettsiosis KW - quadrilateral fever KW - query fever KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590104&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Rickettsioses of domestic animals not transmissible to man. AU - Stoenner, H. G. T2 - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JO - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. JF - Steele, J. H. (Editor-in-Chief): CRC handbook series in zoonoses. Section A: bacterial, rickettsial, and mycotic diseases. Volume II. Y1 - 1980/// SP - 353 EP - 355 CY - Boca Raton, Florida; USA PB - Chemical Rubber Co. Press. AD - Stoenner, H. G.: Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA. N1 - Accession Number: 19820590105. Publication Type: Miscellaneous. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Brief mention is made of a number of diseases of animals caused by rickettsial agents that do not affect man. These include heartwater (caused by Cowdria ruminantium and transmitted by Amblyomma spp.) affecting cattle, sheep and goats; tick-borne fever (caused by Ehrlichia phagocytophila and transmitted by Ixodes ricinus (L.)) affecting sheep and cattle; benign bovine rickettsiosis (caused by E. bovis and transmitted by Hyalomma spp.) affecting cattle; benign bovine rickettsiosis (caused by E. ovina and transmitted by Rhipicephalus bursa C. & F.) affecting sheep; and canine ehrlichiosis (caused by E. canis and transmitted by R. sanguineus (Latr.)), affecting dogs. KW - disease transmission KW - transmission KW - Amblyomma KW - Anaplasma bovis KW - Anaplasma phagocytophilum KW - cattle KW - DOGS KW - Ehrlichia canis KW - Ehrlichia ruminantium KW - GOATS KW - Hyalomma KW - Ixodes ricinus KW - Rhipicephalus bursa KW - Rhipicephalus sanguineus KW - Rickettsiales KW - sheep KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - Ehrlichia KW - Anaplasmataceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - Capra KW - Ixodes KW - Rhipicephalus KW - Ovis KW - Anaplasma KW - bacterium KW - Cowdria ruminantium KW - Ehrlichia bovis KW - Ehrlichia ovina KW - Ehrlichia phagocytophila KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590105&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The burrow ink test and the scabies mite. AU - Woodley, D. AU - Saurat, J. H. JO - Journal of the American Academy of Dermatology JF - Journal of the American Academy of Dermatology Y1 - 1981/// VL - 4 IS - 6 SP - 715 EP - 722 SN - 0190-9622 AD - Woodley, D.: Dermatology Branch, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19820595379. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The burrow ink test (BIT) has been routinely used to diagnose scabies [caused by Sarcoptes scabiei (L.)] at Hopital Saint-Louis, Paris, France. The diagnostic validity of the test was studied by performing a superficial shave biopsy on 25 BIT-positive and 30 BIT-negative scabietic papules from 17 scabies patients and examining the tissue with a light microscope. Microscopic evidence for scabies was found in 100% of BIT-positive lesions and in 36.6% of BIT-negative lesions. The BIT appears to be a valid diagnostic tool. KW - diagnosis KW - ectoparasitoses KW - scabies KW - France KW - Acari KW - man KW - mites KW - Sarcoptes scabiei KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Acari KW - Sarcoptes KW - Sarcoptidae KW - Astigmata KW - mites KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Western Europe KW - Europe KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820595379&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serotypes of tick-borne spotted fever group rickettsiae from western California. AU - Philip, R. N. AU - Lane, R. S. AU - Casper, E. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1981/// VL - 30 IS - 3 SP - 722 EP - 727 SN - 0002-9637 AD - Philip, R. N.: Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19810585678. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A rickettsial survey of ixodid ticks known to bite man was conducted in 1979 in 4 coastal counties of California to obtain isolates from tick species that might be involved in the transmission of spotted fever-like illnesses, and to examine serological characteristics of the rickettsiae relative to defined members of the spotted fever group (SFG). One hundred and seventy (19.4%) of 877 ticks comprising 3 species were shown by the haemolymph test to harbour rickettsia-like organisms. A total of 85 SFG rickettsial isolates was obtained by Vero cell culture; 82 were from Dermacentor occidentalis Marx, 2 from D. variabilis (Say), and 1 from Ixodes pacificus Cooley & Kohls. As determined by microimmunofluorescence, the isolates comprised 4 distinct serotypes. Two serotypes were obtained only from D. occidentalis, and 1 each only from D. variabilis and I. pacificus. Most D. occidentalis isolates possessed the serological characteristics of Rickettsia rhipicephali, but 3 were similar to, yet distinguishable from, R. rickettsii and are members of an unclassified serotype referred to as 364D. The 2 isolates from D. variabilis resembled the unclassified 369C serotype previously shown to be associated with this species and D. andersoni Stiles elsewhere in the USA. The I. pacificus isolate was similar to strains of the unclassified Tillamook serotype isolated from this tick in several localities in western Oregon. Representative strains of the 4 serotypes could be distinguished on the basis of pathogenicity for Vero cells, chick embryos, guinea-pigs and/or meadow voles. The significance of these findings relative to the occurrence of tick-associated illnesses in western California is briefly discussed. KW - California KW - USA KW - Acari KW - Dermacentor occidentalis KW - Dermacentor variabilis KW - Ixodes pacificus KW - Rickettsia rhipicephali KW - Rickettsiales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Ixodes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - spotted-fever rickettsiae KW - United States of America KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helical mycoplasmas (spiroplasmas) from Ixodes ticks. AU - Tully, J. G. AU - Rose, D. L. AU - Yunker, C. E. AU - Cory, J. AU - Whitcomb, R. F. AU - Williamson, D. L. JO - Science, USA JF - Science, USA Y1 - 1981/// VL - 212 IS - 4498 SP - 1043 EP - 1045 AD - Tully, J. G.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19810584288. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A new spiroplasma isolated from examples of Ixodes pacificus Cooley & Kohls collected in Oregon was found to be serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could also be isolated in tick cell cultures. This discovery of a new fastidious mycoplasma in ticks presents opportunities to explore the possible role of these agents in human and animal diseases. KW - Oregon KW - USA KW - Acari KW - Ixodes pacificus KW - Mollicutes KW - Spiroplasmataceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Entomoplasmatales KW - Mollicutes KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - spiroplasmas KW - United States of America KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of an isolate of Rickettsia canada from California. AU - Philip, R. N. AU - Casper, E. A. AU - Anacker, R. L. AU - Peacock, M. G. AU - Hayes, S. F. AU - Lane, R. S. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1982/// VL - 31 IS - 6 SP - 1216 EP - 1221 SN - 0002-9637 AD - Philip, R. N.: Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19830599631. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 57-92-1. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - A strain of Rickettsia canada was recovered in 1980 from an adult of Haemaphysalis leporispalustris (Pack.) taken from a black-tailed jack rabbit (Lepus californicus) in Mendocino County, California. In all biological characteristics examined, this isolate, CA410, was indistinguishable from the prototype, strain 2678, isolated in Ontario, Canada, in 1963. These similarities include serological and immunological reactivity in laboratory mice and guinea-pigs, cultural characteristics in Vero cells, chick embryo cells and embryonated eggs, low pathogenicity for mice, meadow voles (Microtus pennsylvanicus) and guinea-pigs, unusual resistance to streptomycin, morphology by electron microscopy, and molar percentages of guanine plus cytosine of the deoxyribonucleic acids. Recovery of this 2nd strain in the same species of tick, but far removed in time and place from the origin of the prototype, provides evidence that R. canada is an established, ecologically stable, rickettsia in North America. KW - disease vectors KW - distribution KW - hosts KW - pathogenicity KW - resistance KW - rickettsial diseases KW - streptomycin KW - vectors KW - California KW - North America KW - USA KW - Acari KW - bacteria KW - guineapigs KW - Haemaphysalis leporispalustris KW - Lepus californicus KW - Metastigmata KW - mice KW - Microtus pennsylvanicus KW - Rickettsia canadensis KW - Rickettsiales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - prokaryotes KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Haemaphysalis KW - Ixodidae KW - Metastigmata KW - Acari KW - Lepus KW - Leporidae KW - Lagomorpha KW - Muridae KW - Microtus KW - Arvicolinae KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - guinea pigs KW - Rickettsia canada KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830599631&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of Aedes aegypti with zygotes of Plasmodium gallinaceum fertilized in vitro. AU - Rosenberg, R. AU - Koontz, L. C. AU - Carter, R. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1982/// VL - 68 IS - 4 SP - 653 EP - 656 SN - 0022-3395 AD - Rosenberg, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19820597709. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology N2 - In studies in the USA, it was found that female gametes of Plasmodium gallinaceum that had been fertilised in vitro, cleaned of all blood constituents, resuspended in blood and fed to females of Aedes aegypti (L.) through a membrane remained infective. At the lowest zygote concentration (104/ml), almost every ingested parasite produced an oocyst. As the concentration ingested increased, the efficiency diminished, and above 107 zygotes/ml, the number of oocysts produced was constant. This method should be of value to determine the nutrient requirements of the ookinete and early oocyst and to study the effect of immune sera on these stages in vitro. KW - disease vectors KW - in vitro fertilization KW - infection KW - infectivity KW - mosquito nets KW - parasites KW - techniques KW - vectors KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - insects KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - infection techniques KW - mosquitoes KW - Plasmodium gallinaceum zygotes KW - sporogony in Aedes aegypti KW - Techniques and Methodology (ZZ900) KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820597709&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Altered expression of Plasmodium knowlesi variant antigen on the erythrocyte membrane in splenectomized rhesus monkeys. AU - Barnwell, J. W. AU - Howard, R. J. AU - Miller, L. H. JO - Journal of Immunology JF - Journal of Immunology Y1 - 1982/// VL - 128 IS - 1 SP - 224 EP - 226 AD - Barnwell, J. W.: National Inst. of Allergy, National Institutes of Health, Bethesda, MD 10105, USA. N1 - Accession Number: 19820894077. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology N2 - Variant antigens are present on the surface of Plasmodium knowlesi infected erythrocytes as detected by the schizont-infected cell agglutination (SICA) assay. Parasitized erythrocytes passaged in splenectomized monkeys did not agglutinate with immune sera. On the first passage from intact to splenectomized monkeys, the SICA titres decreased 4- to 16-fold; after the 2nd and subsequent passages in splenectomized monkeys, the infected cells became non-agglutinable to all sera tested, including sera from animals infected with the non-agglutinating parasites. This loss of agglutinability could have resulted from selection of a genetically distinct subpopulation of the original parasites or the ability of the original parasites to alter their phenotypic expression. The new nonagglutinable phenotype is designated SICA [-], and the agglutinable phenotype, SICA [+]. The loss of agglutinability indicates that the variant antigen normally expressed on the erythrocyte membrane of infected cells is altered or absent. Because SICA [-] parasites developed in the absence of the spleen, the major organ of host defence against malaria, then this organ may in some manner influence or modulate antigenic expression in P. knowlesi and possibly other malaria parasites. [AS] KW - immunology KW - parasites KW - spleen KW - Macaca mulatta KW - Plasmodium knowlesi KW - Primates KW - protozoa KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - antigenic expression KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820894077&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lyme disease - a tick-borne spirochetosis?. AU - Burgdorfer, W. AU - Barbour, A. G. AU - Hayes, S. F. AU - Benach, J. L. AU - Grunwaldt, E. AU - Davis, J. P. JO - Science, USA JF - Science, USA Y1 - 1982/// VL - 216 IS - 4552 SP - 1317 EP - 1319 AD - Burgdorfer, W.: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19820595479. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology N2 - During a laboratory study carried out in the USA, a Treponema-like spirochaete was detected in and isolated from adults of Ixodes dammini Spielman, Clifford, Piesman & Corwin, the incriminated vector of Lyme disease, collected by flagging in New York State. Long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10-12 weeks after infected ticks had fed on them may have been causally related to the spirochaetes. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to the spirochaete. The results suggested that the newly discovered spirochaete may be involved in the aetiology of Lyme disease. KW - aetiology KW - arthritis KW - New York KW - USA KW - Acari KW - bacteria KW - Ixodes scapularis KW - man KW - Spirochaetales KW - Treponema KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Spirochaetes KW - Bacteria KW - Spirochaetaceae KW - Spirochaetales KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - causal agents KW - etiology KW - Ixodes dammini KW - possibly causing Lyme disease KW - Schizomycetes KW - spirochaete implicated KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820595479&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of antigens on mosquito midgut stages of Plasmodium gallinaceum. I. Zygote surface antigens. AU - Kaushal, D. C. AU - Carter, R. AU - Howard, R. J. AU - McAuliffe, F. M. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1983/// VL - 8 IS - 1 SP - 53 EP - 69 SN - 0166-6851 AD - Kaushal, D. C.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19840517842. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - The surface protein antigens on zygotes of Plasmodium gallinaceum were defined using radioiodination methods and rabbit anti-zygote serum, which blocks transmission of the parasite to Aedes aegypti (L.). KW - Antigens KW - disease vectors KW - Immunology KW - mosquito nets KW - parasites KW - Proteins KW - surface antigens KW - vectors KW - zygotes KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenicity KW - immunogens KW - mosquitoes KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840517842&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of a cultivable spirochete from Ixodes ricinus ticks of Switzerland. AU - Barbour, A. G. AU - Burgdorfer, W. AU - Hayes, S. F. AU - Péter, O. AU - Aeschlimann, A. JO - Current Microbiology JF - Current Microbiology Y1 - 1983/// VL - 8 IS - 2 SP - 123 EP - 126 SN - 0343-8651 AD - Barbour, A. G.: Laboratory of Microbial Structure and Function, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19840515889. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A cultivable spirochaete was isolated from adults of Ixodes ricinus (L.) collected from an area of Switzerland where erythema chronicum migrans, a tick-borne inflammatory disorder, is endemic. The spirochaete was very similar in its morphology, polyacrylamide-gel-electrophoresis profile and antigenic determinants to one previously isolated from I. dammini Spielman, Clifford, Piesman & Corwin in the USA. KW - disease vectors KW - distribution KW - vectors KW - Switzerland KW - Acari KW - bacteria KW - Ixodes ricinus KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - Developed Countries KW - EFTA KW - OECD Countries KW - Western Europe KW - Europe KW - bacterium KW - Schizomycetes KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840515889&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Erythema chronicum migrans -- a tickborne spirochetosis. AU - Burgdorfer, W. AU - Barbour, A. G. AU - Hayes, S. F. AU - Peter, O. AU - Aeschlimann, A. JO - Acta Tropica JF - Acta Tropica Y1 - 1983/// VL - 40 IS - 1 SP - 79 EP - 83 SN - 0001-706X AD - Burgdorfer, W.: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19830501546. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Erythema chronicum migrans (ECM) in man is characterised by the formation of a small annular papule that expands centrifugally with an indurated border 0.5-2 cm wide and central clearing. It has been reported throughout Europe, Ixodes ricinus (L.) being the suspected vector of a presumed pathogen. A condition indistinguishable from ECM was first observed in the USA (Wisconsin) in 1970. Clinical and epidemiological investigations at Lyme, Connecticut, led to the description of Lyme disease, an epidemic inflammatory disorder that usually begins with ECM and may be followed months later with severe neurological, cardiac or arthritic syndromes. I. dammini Spielman, Clifford, Piesman & Corwin is thought to be vector of the presumed pathogen in the north-eastern and mid-western USA and I. pacificus Cooley & Kohls in the west. A cultivable spirochaete recently isolated from I. dammini from Shelter I., New York (an area known for the occurrence of Lyme disease), produced symptoms resembling ECM in rabbits, and a morphologically indistinguishable spirochaete was subsequently recovered from the blood of 2 patients with Lyme disease. The authors report that 73 of 201 examples of I. ricinus collected in spring 1982 on the east shore of Lake Neuchatel, Bern, Switzerland (where ECM has occurred sporadically), were found to be infected with a spirochaete morphologically and immunologically indistinguisable from that isolated from I. dammini. It appears that the spirochaete is the aetiological agent both of Lyme disease in the USA and of ECM in Europe. Studies are in progress to determine the development of the pathogen in Ixodes and to clarify the transmission mechanism(s). KW - arthritis KW - disease vectors KW - distribution KW - erythema chronicum migrans KW - hosts KW - Lyme disease KW - vectors KW - New York KW - Switzerland KW - USA KW - Acari KW - bacteria KW - Ixodes pacificus KW - Ixodes ricinus KW - Ixodes scapularis KW - man KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - EFTA KW - Western Europe KW - Europe KW - bacterium KW - Ixodes dammini KW - lyme borreliosis KW - Schizomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830501546&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. AU - Barbour, A. G. AU - Tessier, S. L. AU - Todd, W. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1983/// VL - 41 IS - 2 SP - 795 EP - 804 SN - 0019-9567 AD - Barbour, A. G.: Laboratory of Microbial Structure & Function, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana 59840, USA. N1 - Accession Number: 19842011158. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - Ixodid tick-associated spirochetes have been implicated as the etiological agents of Lyme disease. We raised a murine monoclonal antibody (H5332) against a spirochete, strain B31, isolated from Ixodes dammini ticks. In indirect immunofluorescence assays and western blot analyses, H5332 reacted with whole cells or isolated components of not only strain B31 but also spirochetes isolated from Ixodes ricinus ticks, a field mouse, a raccoon, and patients with Lyme disease. In contrast, H5332 did not bind to representative borreliae, treponemes, and leptospires. Using indirect immunofluorescence assays and immune electron microscopy, we found the H5332 determinant to be diffusely distributed over the surface of prefixed spirochetes but to be aggregated in patches when the organisms were incubated with H5332 and a second ligand before fixation. Radioimmunoprecipitation and western blot studies revealed the H5332 determinant to be either on or tightly associated with an abundant outer membrane protein with an apparent subunit molecular weight of 31 000.AS<new para>ADDITIONAL ABSTRACT:<new para>Spirochaetes associated with ixodid ticks have been implicated as the aetiological agents of Lyme disease. The murine monoclonal antibody H5332 against the spirochaete strain B31 was isolated from Ixodes dammini Spielman, Clifford, Piesman & Corwin. The antibody reacted with whole cells or isolated components of B31 and with spirochaetes isolated from I. ricinus (L.), a white-footed mouse [Peromyscus leucopus], a raccoon and patients with Lyme disease. The H5332 determinant was found to be diffusely distributed over the surface of prefixed spirochaetes, but to be aggregated in patches when the organisms were incubated with H5332 and a second ligand before fixation. The H5332 determinant was either on or tightly associated with an abundant outer membrane protein with an apparent subunit molecular weight of 31 000. KW - aetiology KW - antigens KW - disease vectors KW - Lyme disease KW - surface antigens KW - surfaces KW - vectors KW - Acari KW - Ixodes scapularis KW - Metastigmata KW - Spirochaetaceae KW - Spirochaetales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - causal agents KW - due to spirochaete from Ixodes dammini KW - etiology KW - immunogens KW - Infectious arthritis KW - Ixodes dammini KW - lyme borreliosis KW - Schizomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842011158&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that anti-idiotype induced immunity to experimental African trypanosomiasis is genetically restricted and requires recognition of combining site-related idiotypes. AU - Sacks, D. L. AU - Sher, A. JO - Journal of Immunology JF - Journal of Immunology Y1 - 1983/// VL - 131 IS - 3 SP - 1511 EP - 1515 AD - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19840176219. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 308067-57-4. Subject Subsets: Animal Breeding; Tropical Diseases N2 - Of 3 allogeneic anti-idiotype antibodies raised against 3 protective monoclonal antibodies, each with specificity for the variant surface antigen of a clone of Trypanosoma rhodesiense, only 1 (anti-7H11 Id) was effective in immunizing BALB/c mice against homologous challenge. The immunity was restricted to mice bearing genes linked to Igh-Ca, which appeared to control expression of this idiotype, both in response to infection and anti-idiotype treatment. Another idiotype, 11D5, appeared to be under similar genetic control. KW - antibodies KW - Disease resistance KW - experimental infections KW - genes KW - idiotypes KW - Immunogenetics KW - immunoglobulins KW - immunology KW - mice KW - Trypanosoma KW - Trypanosoma brucei KW - Trypanosoma rhodesiense KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - Trypanosoma KW - gamma-globulins KW - Igh-Ca restriction KW - immune globulins KW - resistance to disease KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840176219&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease. AU - Hayes, S. F. AU - Burgdorfer, W. AU - Barbour, A. G. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1983/// VL - 154 SP - 1436 EP - 1439 SN - 0021-9193 AD - Hayes, S. F.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19840515016. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The authors describe a bacteriophage detected by electron microscopy in the USA in a spirochaete isolated from the tick Ixodes dammini Spielman, Clifford, Piesman & Corwin. The spirochaete is the causal agent of Lyme disease. KW - bacteriophages KW - disease vectors KW - Lyme disease KW - vectors KW - USA KW - Acari KW - Ixodes scapularis KW - Spirochaetaceae KW - viruses KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - infectious arthritis KW - Ixodes dammini KW - lyme borreliosis KW - phages KW - Schizomycetes KW - United States of America KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840515016&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Derivatizing reagents for high-performance liquid chromatography detection of peptides at the picomole level. AU - Meek, J. L. JO - Journal of Chromatography JF - Journal of Chromatography Y1 - 1983/// VL - 266 SP - 401 EP - 408 SN - 0021-9673 AD - Meek, J. L.: Lab. Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC 20032, USA. N1 - Accession Number: 19841451696. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition KW - Peptides KW - separation KW - separating KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841451696&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vertical transmission of spotted fever group and scrub typhus rickettsiae. AU - Burgdorfer, W. JO - Current Topics in Vector Research JF - Current Topics in Vector Research Y1 - 1984/// VL - 2 SP - 77 EP - 92 CY - New York; USA PB - Praeger Publishers SN - 003071611X AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19920512059. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology N2 - This review examines transovarian transmission of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae, venereal transmission of SFG rickettsiae, and transovarian transmission of R. tsutsugamushi. KW - disease vectors KW - Reviews KW - Sexual transmission KW - Transovarial transmission KW - vertical transmission KW - Acari KW - Ixodidae KW - Orientia tsutsugamushi KW - Rickettsia KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Trombiculidae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Metastigmata KW - Acari KW - Orientia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Prostigmata KW - mites KW - bacterium KW - Rickettsia tsutsugamushi KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920512059&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-lymphotropic retroviruses in adult T-cell leukemia-lymphoma and acquired immune deficiency syndrome. AU - Sarin, P. S. AU - Gallo, R. C. JO - Journal of Clinical Immunology JF - Journal of Clinical Immunology Y1 - 1984/// VL - 4 IS - 6 SP - 415 EP - 423 SN - 0271-9142 AD - Sarin, P. S.: Lab. of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19862029136. Publication Type: Journal Article. Language: English. Number of References: 69 ref. KW - AIDS HTLV clinical KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029136&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Simplified estimation technique for organic contaminant transport in groundwater. AU - Piver, W. T. AU - Lindstrom, F. T. JO - Journal of Hazardous Materials JF - Journal of Hazardous Materials Y1 - 1984/// VL - 8 IS - 4 SP - 331 EP - 339 SN - 0304-3894 AD - Piver, W. T.: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19851994719. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7732-18-5. Subject Subsets: Soils & Fertilizers N2 - The analytical solution for one-dimensional dispersive-advective transport of a single solute in a saturated soil accompanied by adsorption onto soil surfaces and first-order reaction rate kinetics for degradation can be used to evaluate the suitability of potential sites for burial of organic chemicals. The technique can be used to the greatest advantage with organic chemicals that are present in groundwaters in small amounts. The steady-state solution provides a rapid method for chemical landfill site evaluation because it contains the important variables that describe interactions between hydrodynamics and chemical transformation. With this solution, solute concentration, at a specified distance from the landfill site, is a function of the initial concentration and two dimensionless groups. In the first group, the relative weights of advective and dispersive variables are compared, and in the second group the relative weights of hydrodynamic and degradation variables are compared. The ratio of hydrodynamic to degradation variables can be rearranged and written as (aL.λ)/(q/ε), where aL is the dispersivity of the soil, λ is the reaction rate constant, q is groundwater flow velocity, and ε is the soil porosity. When this term has a value less than 0.01, the degradation process is occurring at such a slow rate relative to the hydrodynamics that it can be neglected. Under these conditions the site is unsuitable because the chemicals are unreactive, and concentrations in groundwaters will change very slowly with distance away from the landfill site. KW - hydrodynamic dispersion KW - landfills KW - models KW - organic compounds KW - POLLUTION KW - soil KW - transport processes KW - water KW - environmental pollution KW - organic chemicals KW - soil transport processes KW - transport processes in soil systems KW - Pollution and Degradation (PP600) KW - Engineering and Equipment (General) (NN000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Soil Chemistry and Mineralogy (JJ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851994719&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A checklist of types of Ixodoidea (Acari) in the collection of the Rocky Mountain Laboratories. AU - Keirans, J. E. AU - Clifford, C. M. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1984/// VL - 21 IS - 3 SP - 310 EP - 320 SN - 0022-2585 AD - Keirans, J. E.: National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19840517820. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - The Rocky Mountain tick collection contains over 160 000 separate collections, including about 740 of the 850 described species worldwide and about 300 types. A checklist of the types is presented. KW - taxonomy KW - type specimens KW - North America KW - USA KW - Acari KW - Argasidae KW - Ixodidae KW - Metastigmata KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Metastigmata KW - Acari KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Rocky Mountain Laboratories KW - systematics KW - type collection KW - United States of America KW - Taxonomy and Evolution (ZZ380) KW - Biological Resources (Animal) (PP710) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840517820&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The constancy of parent-offspring similarity of total cholesterol throughout childhood and early adult life. The Lipid Research Clinics Program Prevalence Study. AU - Greenberg, R. A. AU - Green, P. P. AU - Roggenkamp, K. J. AU - Barrett-Connor, E. AU - Tyroler, H. A. AU - Heiss, G. JO - Journal of Chronic Diseases JF - Journal of Chronic Diseases Y1 - 1984/// VL - 37 IS - 11 SP - 833 EP - 838 AD - Greenberg, R. A.: Lipid Metabolism - Atherogenesis Branch, National Heart, Lung and Blood Institute, NIH, Federal Building, Room 402, Bethesda, MD 20205, USA. N1 - Accession Number: 19851469596. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - In a cross-sectional study of 11 409 white parent-offspring pairs in 5 North American populations, the effect of age of the offspring on parent-offspring total cholesterol correlations was examined. In general there was no difference in correlations by age of the offspring for the 4 types (by gender) of parent-offspring pairs. That was true within each of the 5 populations and for the average of all populations combined. For offspring from less than 2 to 29 years old, those average age-specific correlations ranged from 0.17 to 0.42. Despite the considerable physiological and environmental changes which influence cholesterol values from birth to early adulthood, the strength of parent-offspring similarity shows no consistent pattern of change. KW - blood KW - cholesterol KW - correlation KW - Parents KW - progeny KW - North America KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851469596&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rickettsia conorii isolated from Rhipicephalus sanguineus introduced into Switzerland on a pet dog. AU - Péter, O. AU - Burgdorfer, W. AU - Aeschlimann, A. AU - Chatelanat, P. JO - Zeitschrift für Parasitenkunde JF - Zeitschrift für Parasitenkunde Y1 - 1984/// VL - 70 IS - 2 SP - 265 EP - 270 AD - Péter, O.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19842011036. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Veterinary Science N2 - Four people near Geneva, Switzerland, developed a febrile illness during 1980 and 1981 that was diagnosed clinically as boutonneuse fever; all the patients had been in contact with a pet dog which is thought to have introduced the brown dog tick, Rhipicephalus sanguineus into the area from either southern France or Italy in 1976. All the rooms of the house in which the dog lived were infested with ticks and 40% of 75 nymphs and adults examined were infected with a rickettsial agent "biologically and antigenically indistinguishable from Rickettsia conorii".Carolyn A. Brown<new para>ADDITIONAL ABSTRACT:<new para>A survey in a household near Geneva, Switzerland, revealed that 30 (40%) of 75 nymphs and adults of Rhipicephalus sanguineus were infected with a rickettsial agent biologically and antigenically indistinguishable from Rickettsia conorii, the causal agent of boutonneuse fever. Introduced in 1976 from either southern France or Italy by the family's pet dog, the tick infestation had increased steadily until 1981, when control measures were initiated. During 1980-81, 4 persons associated with the dog contracted a febrile illness diagnosed as boutonneuse fever. KW - disease vectors KW - distribution KW - dog diseases KW - hosts KW - Mediterranean spotted fever KW - pets KW - rickettsial diseases KW - Tick infestations KW - tickborne diseases KW - typhus fevers KW - vectors KW - Europe KW - Switzerland KW - Acari KW - dogs KW - man KW - Metastigmata KW - Rhipicephalus KW - Rhipicephalus sanguineus KW - Rickettsia KW - Rickettsia conorii KW - Rickettsiaceae KW - Rickettsiales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - Homo KW - Hominidae KW - Primates KW - Acari KW - Ixodidae KW - Metastigmata KW - Rhipicephalus KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Developed Countries KW - EFTA KW - OECD Countries KW - Western Europe KW - Europe KW - bacterium KW - boutonneuse fever KW - conorii KW - pet animals KW - Rickettsia vector KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842011036&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ticks. An ever increasing public health menace. AU - Burgdorfer, W. JO - Bulletin, Connecticut Agricultural Experiment Station JF - Bulletin, Connecticut Agricultural Experiment Station Y1 - 1984/// IS - 822 SP - 6 EP - 6 AD - Burgdorfer, W.: Department of Health & Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. N1 - Accession Number: 19850525857. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The importance of ticks as vectors of disease pathogens is reviewed and discussed with particular reference to diseases affecting man in the USA. They include babesiosis (caused by Babesia microti, which is transmitted by Ixodes dammini), Lyme disease (caused by a spirochaete, which is also transmitted by I. dammini), erythema chronicum migrans, which is caused by the bite of Ixodes ricinus, and Rocky Mountain spotted fever (caused by Rickettsia rickettsii, which is transmitted by Dermacentor andersoni). KW - bites KW - disease transmission KW - disease vectors KW - hosts KW - human diseases KW - Lyme disease KW - reviews KW - transmission KW - vectors KW - USA KW - Acari KW - Apicomplexa KW - Babesia microti KW - Dermacentor andersoni KW - Ixodes ricinus KW - Ixodes scapularis KW - man KW - METASTIGMATA KW - Rickettsia rickettsii KW - Rickettsiales KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Babesia KW - Babesiidae KW - Piroplasmorida KW - Apicomplexa KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Ixodes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - Ixodes dammini KW - Ixodoidea KW - lyme borreliosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850525857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of ATP analogues on the gorging response of Aedes aegypti. AU - Galun, R. AU - Koontz, L. C. AU - Gwadz, R. W. AU - Ribeiro, J. M. C. JO - Physiological Entomology JF - Physiological Entomology Y1 - 1985/// VL - 10 IS - 3 SP - 275 EP - 281 SN - 0307-6962 AD - Galun, R.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, USA. N1 - Accession Number: 19850529624. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 303-81-1. Subject Subsets: Medical & Veterinary Entomology N2 - The ATP analogues adenylylimidodiphosphate and adenylylmethylenediphosphate were 3-5 times as effective as ATP as gorging stimulants for Aedes aegypti. This increased potency was not due to the fact that the 2 analogues are not hydrolysed by the mosquito salivary apyrase, but most likely to their greater affinity to the mosquito gustatory receptor protein. The analogues 2′d ATP and 3′d ATP were about half as potent as ATP, while 2′,3′-dideoxyadenosine triphosphate was 10 times as potent as ATP in evoking the gorging response. It is proposed that removal of both hydroxyl groups eliminates binding of the stimulant at the ribose moeity, thus allowing the molecule greater freedom to rotate and bind more effectively to its other 2 binding sites at the amino group on the purine and at the terminal phosphate. The data demonstrate that ATP activates the gorging response of A. aegypti merely by binding to its receptor protein and is not required as an exogenous source of energy. The gorging response to ATP is competitively inhibited by novobiocin. KW - effects KW - feeding KW - mosquito nets KW - Novobiocin KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Adenosine 5'-(tetrahydrogen triphosphate) KW - ATP analogues KW - inhibiting gorging response to ATP KW - mosquitoes KW - Other Control Measures (HH700) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850529624&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polymorphism of the 3′ open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III. AU - Ratner, L. AU - Starcich, B. AU - et al. AU - Josephs, S. F. ( JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1985/// VL - 13 IS - 22 SP - 8219 EP - 8229 SN - 0305-1048 AD - Ratner, L.: Lab. of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026840. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Public Health KW - human immunodeficiency viruses KW - open reading frames KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - 3' polymorphism KW - human immunodeficiency virus KW - ORFs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026840&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Laboratory assessment of a species-specific radioimmunoassay for the detection of malaria sporozoites in mosquitoes (Diptera: Culicidae). AU - Collins, F. H. AU - Gwadz, R. W. AU - Koontz, L. C. AU - Zavala, F. AU - Nussenzweig, R. S. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1985/// VL - 22 IS - 2 SP - 121 EP - 129 SN - 0022-2585 AD - Collins, F. H.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19850529414. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology N2 - A radioimmunoassay using monoclonal antibodies (Mabs) specific for the dominant surface antigens of malaria sporozoites was used in the laboratory in the USA to evaluate various factors that might influence the use of similar tests for epidemiological studies. Mabs specific for sporozoites of 2 causal agents of simian malaria, Plasmodium knowlesi and P. cynomolgi, were used to determine the time of antigen appearance and persistence in Anopheles dirus, the conditions under which infected mosquitoes could be stored before processing, and methods of detecting infected mosquitoes in pools or of identifying pools including mosquitoes with more than 1 species of malaria pathogen.<new para>ADDITIONAL ABSTRACT:<new para>A radioimmunoassay (RIA) using monoclonal antibodies (Mabs) specific for the dominant surface antigens of malaria sporozoites was used to evaluate various factors that might influence the use of this or similar tests for epidemiological studies. Mabs specific for sporozoites of 2 simian malaria organisms, Plasmodium knowlesi and P. cynomolgi, were used to determine the time of antigen appearance and persistence in mosquitoes, conditions under which infected mosquitoes can be stored prior to processing, and methods for detecting infected mosquitoes in pools or for identifying pools including mosquitoes carrying more than 1 species of malaria.AS KW - detection KW - disease vectors KW - immunodiagnosis KW - infection KW - monoclonal antibodies KW - mosquito nets KW - parasites KW - radioimmunoassay KW - sporozoites KW - Techniques KW - vectors KW - USA KW - Anopheles KW - Anopheles dirus KW - Apicomplexa KW - Culicidae KW - Diptera KW - Insects KW - Plasmodium KW - Plasmodium cynomolgi KW - Plasmodium knowlesi KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Protozoa KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Haemosporida KW - immunoradiometric assay KW - mosquitoes KW - radioimmunosorbent assay KW - recovery from infected mosquitoes KW - serological diagnosis KW - sporozoite detection KW - United States of America KW - Techniques and Methodology (ZZ900) KW - Other Control Measures (HH700) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850529414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of lysis-centrifugation (Isolator) and radiometric (BACTEC) blood culture systems for the detection of mycobacteremia. AU - Gill, V. J. AU - Park, C. H. AU - Stock, F. AU - Gosey, L. L. AU - Witebsky, F. G. AU - Masur, H. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1985/// VL - 22 IS - 4 SP - 543 EP - 546 SN - 0095-1137 AD - Gill, V. J.: Microbiology Service, Dept of Clinical Pathology, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19862027265. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors compared the sensitivity of a radiometric (BACTEC system) liquid medium culture system with that of conventional solid mycobacterial culture media for cultures of blood from these patients. Both systems were inoculated with blood concentrate prepared by lysis-centrifugation (Isolator). Of 46 AIDS patients whose blood was cultured, 28% had cultures positive for Mycobacterium avium-intracellulare (MAI). Patients had from <1 to >100 MAI colonies/ml of blood. Lowenstein-Jensen and Middlebrook 7H11 agars were comparable for recovery of MAI. BACTEC 12A vials containing double the standard volume of medium (4 ml) were more sensitive and were positive slightly earlier than vials containing the standard volume (2 ml). Conventional media detected 98% of positive cultures; BACTEC vials containing double volumes of medium detected 94% of positive cultures, whereas single-volume vials detected 77%. BACTEC vials were positive about 5-6 days sooner than slants or plates containing conventional media. For a few cultures, the authors compared the use of unconcentrated blood with Isolator-concentrated blood with each of these as inocula for BACTEC vials. Results for these cultures suggested that, although the use of Isolator-concentrated blood resulted in greater sensitivity than the use of unconcentrated blood would, the use of unconcentrated blood would still result in the detection of at least 78% of positive cultures.J.K. Schönfeld KW - acquired immune deficiency syndrome KW - blood KW - culture techniques KW - detection KW - infections KW - mycobacterial diseases KW - systems KW - USA KW - Mycobacterium KW - Mycobacterium avium complex KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterium KW - mycobacterial infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027265&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Brunfelsamidine: a novel convulsant from the medicinal plant Brunfelsia grandiflora. AU - Lloyd, H. A. AU - Fales, H. M. AU - Goldman, M. E. AU - Jerina, D. M. AU - Plowman, T. AU - Schultes, R. E. JO - Tetrahedron Letters JF - Tetrahedron Letters Y1 - 1985/// VL - 26 IS - 22 SP - 2623 EP - 2624 SN - 0040-4039 AD - Lloyd, H. A.: National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19850330387. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Horticultural Science N2 - The convulsant, isolated from root bark collected in Peru, was characterized as pyrrole-3-carboxamidine. KW - medicinal plants KW - plant composition KW - Peru KW - Brunfelsia KW - Solanaceae KW - Solanales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Andean Group KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - South America KW - Brunfelsia grandiflora KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - Plant Science (General) (FF000) KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850330387&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence of HTLV-I an arctic regions. AU - Robert-Guroff, M. AU - Clark, J. AU - et al. AU - Lanier, A. P. ( JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1985/// VL - 36 IS - 6 SP - 651 EP - 655 SN - 0020-7136 AD - Robert-Guroff, M.: National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026910. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Sera of native inhabitants of Arctic regions were assayed for antibodies to HTLV-I by the ELISA technique followed by competition experiments to confirm antibody specificity. Residents of 7 widely separated Alaskan villages exhibited prevalence rates of 0 to 12% for HTLV-I antibodies. Less than 1% of Greenland Eskimos were HTLV-I antibody-positive. Residents of 3 northern Swedish regions ranged in HTLV-I antibody prevalence from 0 to 5%. Sera of healthy native inhabitants of Alaska and northern Sweden were similarly assayed for antibodies to HTLV-II. No additional sera were shown to be positive for HTLV-II antibodies. While some of the HTLV-I antibody-positive sera exhibited cross-reactivity with HTLV-II antigens, competition experiments using disrupted HTLV-II or purified HTLV-I p24 as test antigens indicated that the primary antibody response in all cases tested was elicited by HTLV-I. [The authors'] results show that HTLV-I distribution is not restricted to endemic areas in warm, humid climates, but extends to Arctic regions. Within these regions, HTLV-I exhibits the same restricted distribution seen in other areas where virus infection is prevalent. The Arctic does not seem to be a reservoir for HTLV-II infection. The origin of HTLV-I in Arctic areas is not known. One may speculate that foreign visitors introduced the virus into Aleut and Lapp populations, and that it has been maintained there and restricted in its distribution as a result of close familial relationships.AS KW - HTLV infections KW - Alaska KW - Europe KW - Greenland KW - North America KW - Sweden KW - USA KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - European Union Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Arctic populations KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026910&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clonal analysis of T lymphocytes in the acquired immunodeficiency syndrome: evidence for an abnormality affecting individual helper and suppressor T cells. AU - Margolick, J. B. AU - Volkman, D. J. AU - Lane, H. C. AU - Fauci, A. S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1985/// VL - 76 IS - 2 SP - 709 EP - 715 SN - 0021-9738 AD - Margolick, J. B.: National Institutes of Health, Bldg 10, Rm 11B-13, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026294. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Studies on peripheral blood mononuclear cells from patients with AIDS have only just begun to resolve the question of whether the immune abnormalities are secondary to abnormal proportions or numbers of cells or intrinsic functional defects. This study examines the function of cloned rather than heterogeneous T-cell populations in 8 patients with AIDS compared to 8 healthy heterosexual control subjects. Purified T4 and T8 cells from patients with AIDS gave rise to about 85% fewer clones, compared to the controls. This abnormality could not be attributed to variability in circulating numbers. This suggests an intrinsic defect in their ability to proliferate and expand clonally. However, the cloned T-cells from AIDS patients demonstrated normal proliferative responses to phytohaemagglutinin and alloantigen and normal help and suppression in a pokeweed mitogen-driven IgG synthesis assay. This functional abnormality, since it affects both T4 and T8 cells is unlikely to be due to a direct infection with HTLV-III. The possible roles of other infectious agents, activation states and depletion of more clonable T-cell subpopulations are discussed.I.V.D. Weller KW - acquired immune deficiency syndrome KW - immunology KW - AIDS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026294&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-III in homosexual men: selective loss of an influenza-specific, human leukocyte antigen-restricted cytotoxic T lymphocyte response in human T lymphotropic virus-III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome. AU - Shearer, G. M. AU - Salahuddin, S. Z. AU - et al. AU - Markham, P. D. ( JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1985/// VL - 76 IS - 4 SP - 1699 EP - 1704 SN - 0021-9738 AD - Shearer, G. M.: Immunology Branch and Laboratory of Tumor Cell Biology of the National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026962. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Peripheral blood leucocytes from 18 homosexual men and 9 heterosexual male control subjects repeatedly tested over a 2-year period for the presence of cytotoxic T-lymphocyte (CTL) responses to influenza virus recognized in association with self HLA antigens for the presence of HTLV-III antibodies. Homosexual donors who were CTL responders retained their respective CTL profile for up to 2 years. Peripheral leucocytes from patients with AIDS generated no CTL activity to influenza virus but there was commonly CTL responses to HLA alloantigens. The selective loss of an HLA-restricted cytotoxic T-lymphocyte response without loss of HLA alloantigenic cytotoxic T-lymphocyte activity may be an important characteristic in the development of AIDS and may be used in therapeutic protocols at early stages of the disease. This mechanism may provide T-cell help by alloantigen-induced interleukin-2 production which may be of value in surveillance against opportunistic infection. However, it is also possible that elevated T-cell function results in increased immune destruction of HTLV-III-infected lymphocytes and would thus lead to a further decline of the immune system.G.W. Csonka KW - Acquired immune deficiency syndrome KW - HIV infections KW - homosexuality KW - human immunodeficiency viruses KW - immunology KW - influenza viruses KW - men KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthomyxoviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cytotoxic T lymphocyte response to influenza virus KW - HLA self-restricted cytotoxic T lymphocyte response KW - homosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Influenzavirus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. AU - Folks, T. AU - Benn, S. AU - et al. AU - Rabson, A. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1985/// VL - 82 IS - 13 SP - 4539 EP - 4543 SN - 0027-8424 AD - Folks, T.: Office of the Scientific Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19852025793. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A cell line, originally isolated from a child with acute lymphocytic leukaemia, was cultured in the presence of 8-azaguanine to produce a clone hypoxanthine/aminopterin/thymine (HAT)-sensitive continuous cell line. These cultured T cells were sensitive to infection with HTLV-III virus which produced a cytopathic effect, infected cells dying over a period of 3-5 days which coincided with the peak of reverse transcriptase activity. Some preliminary studies, using restriction endonuclease analysis, showed that there were no changes on adaptation of HTLV-III to these cells, designated A3.01 cells.[See also abstract above.]R.N.P. Sutton KW - cell cultures KW - human immunodeficiency viruses KW - USA KW - man KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - A3.01 continuous line KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025793&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. AU - Hahn, B. H. AU - Gonda, M. A. AU - et al. AU - Shaw, G. M. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1985/// VL - 82 IS - 14 SP - 4813 EP - 4817 SN - 0027-8424 AD - Hahn, B. H.: Lab. of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19862026122. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - ... [The authors] compared the molecularly cloned genomes of two variant HTLV-III isolates by extensive restriction enzyme mapping and heteroduplex thermal melt analysis. Both viral isolates were found to be highly related to each other throughout their entire genomic complement, yet they differed markedly in their restriction enzyme maps. Electron microscopic heteroduplex analysis revealed several distinct regions of divergence located almost exclusively in the part of the genome that encodes the viral envelope gene. In vitro culture of one of these viruses over a period of 3 months did not result in any genomic changes as determined by restriction analysis of viral DNA. These results, as well as the recently published nucleotide sequences of other HTLV-III isolates, indicate that the most substantial variaton among HTLV-III isolates is located in the envelope. ...AS KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - human immunodeficiency viruses KW - USA KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - genomic diversity KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026122&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of infectious T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources. AU - Salahuddin, S. Z. AU - Markham, P. D. AU - et al. AU - Popovic, M. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1985/// VL - 82 IS - 16 SP - 5530 EP - 5534 SN - 0027-8424 AD - Salahuddin, S. Z.: Lab. of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19862026123. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Since late 1982 the authors have isolated infectious virus from 47 AIDS patients (out of 93 attempted), 35 of 41 patients with "AIDS-related complex" and 19 of 67 clinically healthy donors at risk for AIDS. Virus was isolated mostly from peripheral blood lymphocytes but also from bone marrow, lymph nodes, brain tissue, cell-free plasma, and from cells associated with saliva, cerebrospinal fluid and semen. The risk groups included homosexuals, promiscuous heterosexuals, intravenous drug users, recipients of blood or blood products, and spouses and offspring of AIDS patients and others at risk for AIDS. "A high correlation was seen between persistent levels of serum antibody and the ability to isolate virus from patient or donor leukocytes. Immunologic and nucleic acid analysis demonstrated that the virus isolates were highly related, although substantial diversity was observed in the restriction enzyme cleavage patterns of those studied in detail. Biological analysis of cells from infected patients and donors as well as from normal peripheral blood mononuclear cells exposed to virus in vitro demonstrated that OKT4/Leu3a+ (helper/inducer) lymphocytes were preferentially infected and were subjected to a characteristic cytopathic effect."D.W. FitzSimons KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - human immunodeficiency viruses KW - USA KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - United States of America KW - various tissues of risk groups KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. AU - Mitsuya, H. AU - Weinhold, K. J. AU - et al. AU - Furman, P. A. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1985/// VL - 82 IS - 20 SP - 7096 EP - 7100 SN - 0027-8424 AD - Mitsuya, H.: The Clinical Oncology Program, National Cancer Institute, Bethesda, MA 20205, USA. N1 - Accession Number: 19862027103. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Azidodeoxythymidine blocks expression of the p24 gag protein at 5-10 µmol/l and protects target T cells against the cytopathic effects of strains of HTLV-III that differ by about 20% in their env gene amino acid sequence. At ≥0.5 µmol/l it also blocks viral replication in normal human peripheral blood mononuclear cells exposed to HTLV-III, as measured by reverse transcriptase activity. Concentrations up to 50 µmol/l only slightly inhibit some immunological reactivities of normal T cells, and when given in high doses (85-150 mg/kg body weight) to rats and dogs for up to 4 weeks it caused little or no toxicity. The authors note that the compound is a competitive inhibitor of the reverse transcriptase of HTLV-III as the triphosphate but that the unphosphorylated parent does not inhibit the enzyme per se.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - inhibition KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - Azidothymidine KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027103&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell growth factor (interleukin 2) and γ-interferon genes: expression in human T-lymphotropic virus type III- and type I-infected cells. AU - Arya, S. K. AU - Gallo, R. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1985/// VL - 82 IS - 24 SP - 8691 EP - 8695 SN - 0027-8424 AD - Arya, S. K.: Lab of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862027454. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors postulated that T-cell depletion in AIDS was due to impaired synthesis of T-cell growth factor (TCGF, interleukin-2) and that adult T-cell leukaemia was due to unregulated production of the latter. "The results reported here show that the transcription of the TCGF gene was not impaired in cultured HTLV-III-infected cells. Paradoxically, the TCGF gene in HTLV-I-infected cells was transcriptionally inactive. The reverse was the case for the γ-interferon gene-it was actively transcribed in HTLV-I-infected cells but not in the HTLV-III-infected and virus-producing H9 and H4 cell line. No evidence was obtained suggesting abnormal regulation of the TCGF or of the IFN-γ gene consequent to HTLV-III infection. It thus appears that in both HTLV-III and HTLV-I infection, growth control and immune regulatory mechanisms may bypass a modulatory role of TCGF or of IFN-γ."AS/D.W. FitzSimons KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Human T-cell lymphotropic virus KW - AIDS KW - gene induction KW - HTLV-BLV group KW - human immunodeficiency virus KW - human innunodeficiency virus KW - interleukin 2 and gamma-interferon genes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027454&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Importance of western blot analysis in predicting infectivity of anti-HTLV-III/LAV positive blood. AU - Esteban, J. I. AU - Shih, J. W. K. AU - Tai, C. C. AU - Bodner, A. J. AU - Kay, J. W. D. AU - Alter, H. J. JO - Lancet JF - Lancet Y1 - 1985/// VL - ii SP - 1083 EP - 1086 AD - Esteban, J. I.: Dept of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19852025748. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Stored donor and recipient sera from prospective studies of post-transfusion hepatitis were analysed for the presence of human T-cell lymphotropic virus type-III/lymphadenopathy associated virus (HTLV-III/LAV) antibodies as determined by enzyme-linked immunosorbent assays (ELISA). Of 3961 donors samples given to 461 patients, only 2 (0.05%) contained specific HTLV-III/LAV antibodies as determined by an avidin-biotin-enhanced western blot technique. Anti-HTLV-III/LAV was measured before and 3 and 6 months after transfusion in 295 recipients of anti-HTLV-III-negative blood, 7 recipients of ELISA-positive blood which was western blot negative, and 2 recipients of ELISA-positive blood confirmed as specific by western blot. Only the last 2 recipients became infected with HTLV-III/LAV, as assessed by antibody seroconversion (P <0.0001). Seroconverion occurred early (6 and 8 weeks after transfusion) and was characterised first by antibody to p24 and later by antibody to p41. AIDS has not developed in either patient, but one has a T4/T8 ratio of 0.4 and impaired mitogen responses; the second patient has no evidence of immune dysfunction 4 years after exposure. This study confirms that HTLV-III/LAV infection can be transmitted by blood transfusion and supports the advisability of anti-HTLV-III/LAV testing of all blood donors. It also confirms the validity of western blot testing for HTLV-III/LAV specificity and suggests that ELISA-positive, western-blot-negative blood may not be infectious.AS KW - human immunodeficiency viruses KW - infections KW - prevention KW - transfusion KW - transmission KW - viral diseases KW - western blotting KW - USA KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025748&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HTLV-I and HTLV-III antibodies and tropical spastic paraparesis. AU - Rodgers-Johnson, P. AU - Gajdusek, D. C. AU - Morgan, O. St C. AU - Zaninovic, V. AU - Sarin, P. S. AU - Graham, D. S. T2 - Lancet JO - Lancet JF - Lancet Y1 - 1985/// VL - ii SP - 1247 EP - 1248 AD - Rodgers-Johnson, P.: Lab. of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19862029024. Publication Type: Correspondence. Language: English. Subject Subsets: Tropical Diseases N2 - Antibodies to HTLV-I and to HTLV-III were estimated in sera and cerebrospinal fluid (CSF) from patients with tropical spastic paraparesis in Jamaica and in Colombia. Few possessed HTLV-III antibodies but the proportion with HTLV-I antibodies ranged from 55% in Jamaican CSF to 100% in Colombian sera. These results confirm similar findings in patients with the same condition in Martinique and suggest that further epidemiological and other studies are indicated.[These reports of the association of retrovirus infection with neurological disease add a further dimension to the possible role of this group of viruses.]R.N.P. Sutton KW - acquired immune deficiency syndrome KW - HTLV infections KW - patients KW - serological surveys KW - tropical spastic paraparesis KW - Caribbean KW - Colombia KW - Jamaica KW - South America KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Andean Group KW - Latin America KW - South America KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - seroepidemiology KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029024&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cryptococcosis in the acquired immunodeficiency syndrome. AU - Kovacs, J. A. AU - Kovacs, A. A. AU - et al. AU - Polis, M. ( AU - Gelmann, E. P.\Lane, H. C.\Longfield, R.\Overturf, G.\Macher, A. M.\Fauci, A. S.\Porrillo, J. E.\Bennett, J. E.\Masur, H. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1985/// VL - 103 IS - 4 SP - 533 EP - 538 SN - 0003-4819 AD - Kovacs, J. A.: Critical Care Medical Dept, Clinical Center, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026274. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - Clinical aspects of disease in patients with AIDS and Cryptococcus neoformans infection from 6 medical centres in the USA are reviewed retrospectively. In 7 cryptococcosis was the initial feature and in a further 7 (who presented with Kaposi's sarcoma) the earliest opportunistic infection; 25 patients had at least one other opportunistic process at some time during their clinical course. The most common clinical manifestation of cryptococcal infection was meningitis plus encephalitis (in 18); culture (100%), cryptococcal antigen (100%) and Indian ink test (82%) on cerebrospinal fluid were of great value in diagnosis in those tested. In those without meningitis blood cultures and serum cryptococcal antigen were sometimes positive. After a course of treatment (amphotericin B plus flucytosine, or amphotericin B alone) only 10 of 24 had no evidence of continuing infection and of these 6 had clinical relapses, leading to death in at least 2 of them. Orthodox management of cryptococcosis is thus extremely unsatisfactory in AIDS sufferers; this might be improved by earlier diagnosis or long-term therapy. Overall, cryptococcosis seemed to play a major part in 9 deaths.(At the National Institutes of Health C. neoformans ranks fourth, after cytomegalovirus, Pneumocystis carinii and Mycobacterium avium-intracellulare, as a life-threatening infection in AIDS patients.)G.C. Cook<new para>ADDITIONAL ABSTRACT:<new para>The clinical course and response to therapy of 27 patients with Cryptococcus neoformans and acquired immune deficiency syndrome (AIDS) were reviewed. Cryptococcosis was the initial manifestation of the syndrome in 7 patients and the initial opportunistic infection in an additional 7. Meningitis was the commonest clinical feature (18 patients). Blood cultures and serum cryptococcal antigen were frequently positive. In patients with meningitis, leukocyte count, protein level and glucose level in cerebrospinal fluid were frequently normal; cerebrospinal fluid India ink test (82%), culture (100%) and cryptococcal antigen (100%) were usually positive. Of 24 patients treated with amphotericin B alone or in combination with flucytosine [5-fluorocytosine], only 10 had no evidence of infection after completion of therapy; 6 of these 10 had relapses shown by clinical findings or at autopsy. KW - acquired immune deficiency syndrome KW - cryptococcosis KW - hosts KW - infection KW - predisposition KW - USA KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - european blastomycosis KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026274&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genomic diversity of human T-lymphotropic virus type III (HTLV-III). AU - Wong-Staal, F. AU - Shaw, G. M. AU - et al. AU - Hahn, B. H. ( JO - Science, USA JF - Science, USA Y1 - 1985/// VL - 229 IS - Aug. 23 SP - 759 EP - 762 AD - Wong-Staal, F.: Lab. of Tumour Cell Biology, National Cancer Institute, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19852025795. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2. Subject Subsets: Public Health N2 - Eighteen HTLV-III isolates were subjected to restriction endonuclease analysis. All were different and the number of restriction-site differences ranged from 1 to at least 16. There was no relationship to clinical features but isolates recovered at about the same time from patients in similar areas had close restriction patterns; isolates from Californian and Haitian patient differed considerably. In most patients only one predominant form of virus was identified, suggesting either selective pressures during cultivation in vitro or that some kind of interference may occur as these patients were probably subjected to repeated exposure to different viruses.[Further studies with HTLV-III clearly demonstrate that fresh problems are arising.]R.N.P. Sutton KW - DNA KW - human immunodeficiency viruses KW - nucleic acids KW - USA KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - deoxyribonucleic acid KW - genomic diversity KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025795&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genomic heterogeneity of AIDS retroviral isolates from North America and Zaïre. AU - Benn, S. AU - Rutledge, R. AU - et al. AU - Folks, T. ( JO - Science, USA JF - Science, USA Y1 - 1985/// VL - 230 SP - 949 EP - 951 AD - Benn, S.: Lab. of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19862027931. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - HTLV-III strains were recovered from patients in New York and Alabama, USA, and Zaïre (plus a prototype LAV strain). DNA was extracted and subjected to restriction endonuclease analysis, using 7 enzymes. Some sites of restriction were present in every strain and could be considered a signature of the AIDS virus. The one French (LAV) and 8 North American isolates (including ARV-2) contained 20-24 of the 24 conserved restriction sites; by contrast, the 3 Zaïrean strains retained only 14 or 15 of these sites. The African isolates contained a greater number of distinctive restriction enzyme sites than the French or American ones, but the difference was not as striking as the loss of conserved sites. The authors clearly demonstrate the heterogeneity of AIDS retrovirus genomes.R.N.P. Sutton KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - strains KW - Africa KW - Congo Democratic Republic KW - North America KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - American and Zairean KW - genomic heterogeneity KW - human immunodeficiency virus KW - United States of America KW - Zaire KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027931&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HTLV-III infection among health care workers: association with needle-stick injuries. AU - Weiss, S. H. AU - Saxinger, C. AU - et al. AU - Rechtman, D. ( AU - Grouse, L. D.\Stricof, R. L.\Morse, D. L. JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1985/// VL - 254 IS - 15 SP - 2089 EP - 2093 AD - Weiss, S. H.: Environmental Epidemiology Branch, National Cancer Institute, Landow Bldg, Rm 3C29, Bethesda, MD 20205, USA. N1 - Accession Number: 19862029093. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Some 361 health-care personnel at medical centres in several metropolitan areas of the USA volunteered for HTLV-III testing and provided background information about risk factors. Sera were tested by ELISA and borderline or positive samples were retested by Western blot. Six (26%) of 23 such personnel with recognized risk factors for AIDS were seropositive. Three health-care workers and a clinical laboratory worker, who did not belong to recognized AIDS risk groups, were seropositive, although one has not volunteered for further epidemiological investigation. Case reports of the other 3 are given. All reported possible parenteral exposure (to an AIDS patient or pooled platelets). In one, blood was not available before the needle-stick exposures but other evidence is consistent with occupational exposure. The second is ambiguous because her partner became seropositive but no serum samples for him soon after her exposure were available. The third case represents probable occupational transmission but awaits further investigation [and has subsequently been confirmed, see McGray et al. below. See also an editorial by L.D. Grouse, pp. 2130-2131.]D.W. FitzSimons KW - acquired immune deficiency syndrome KW - disease transmission KW - health care workers KW - HIV infections KW - human immunodeficiency viruses KW - needlestick injuries KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) KW - Human Injuries (VV610) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029093&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterosexually acquired HTLV-III/LAV disease (AIDS-related complex and AIDS): epidemiologic evidence for female-to-male transmission. AU - Redfield, R. R. AU - Markham, P. D. AU - Salahuddin, S. Z. AU - Wright, D. C. AU - Sarngadharan, M. G. AU - Gallo, R. C. AU - Echenberg, D. F. JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1985/// VL - 254 IS - 15 SP - 2094 EP - 2096 AD - Redfield, R. R.: National Cancer Institute, Laboratory of Tumor Cell Biology, Bldg 37, Rm 6A09, Bethesda, MD 20205, USA (Gallo). N1 - Accession Number: 19862029094. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Fifteen of 41 patients with diseases associated with HTLV-III (10 men and 5 women) seen in Washington DC acquired their infections from spouses with AIDS or partners who were at risk for AIDS in 6 cases or from prostitutes (8 cases) or multiple sexual partners (1 case). The contacts with prostitutes were in the USA (New York City and Dallas), Korea and Germany. Receptive anal intercourse is shown not to be a requirement for infection in this group.In an editorial D.F. Echenberg (pp. 2129-2130) proposes that all AIDS patients be interviewed to obtain their heterosexual contacts who should be traced, tested and counselled. He argues that educational campaigns will be more difficult among heterosexual groups than among homosexual ones.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - heterosexual transmission KW - heterosexuality KW - HIV infections KW - human immunodeficiency viruses KW - transmission KW - North America KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - heterosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029094&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variation in human T lymphotropic virus III (HTLV-III) antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS). AU - Biggar, R. J. AU - Melbye, M. AU - et al. AU - Ebbesen, P. ( JO - British Medical Journal JF - British Medical Journal Y1 - 1985/// VL - 291 IS - Oct. 12 SP - 997 EP - 998 AD - Biggar, R. J.: Environmental Epidemiology Branch and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda 20205, Maryland, USA. N1 - Accession Number: 19852025971. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Western blot analysis was used to document the development and changes in human T lymphotropic virus III (HTLV-III) antibody among [250] Danish homosexual men followed longitudinally over three years. Reactivity against p15, p24, and p55 appeared earliest. After seroconversion the antibody concentration fluctuated, but in one instance a steady decline in banding intensity was seen during the 18 months before onset of the acquired immune deficiency syndrome (AIDS) and throughout the remaining eight months of his life.AS KW - acquired immune deficiency syndrome KW - antibodies KW - homosexuality KW - human immunodeficiency viruses KW - infections KW - men KW - viral diseases KW - Denmark KW - man KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - AIDS KW - homosexuals KW - human immunodeficiency virus KW - reductions KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852025971&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Effects of a novel compound (AL 721) on HTLV-III infectivity in vitro. AU - Sarin, P. S. AU - Gallo, R. C. AU - Scheer, D. I. AU - Crews, F. AU - Lippa, A. S. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1985/// VL - 313 IS - 20 SP - 1289 EP - 1290 SN - 0028-4793 AD - Sarin, P. S.: National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862026531. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health N2 - The authors report the results of a preliminary investigation in vitro of a novel compound that appears to restrict the infectivity of HTLV-III for human peripheral blood lymphocytes and helper T cells. The compound (AL 721) is a mixture (7:2:1) of neutral glycerides, phosphatidylcholine and phosphatidylethanolamine; it has previously been shown to extract cholesterol from cellular membranes in vitro and to restore lymphocyte proliferation in healthy, elderly volunteers without adverse effects.AL 721 does not directly inhibit reverse transcriptase and is thought to act by its effect on the retrovirus envelope or on the host-cell membrane.David Greenwood KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - human immunodeficiency viruses KW - inhibition KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - AL 721 KW - AL 721 antiviral agent KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Inactivation of human T-cell lymphotropic retrovirus (HTLV-III) by LDtm. AU - Sarin, P. S. AU - Scheer, D. I. AU - Kross, R. D. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1985/// VL - 313 IS - 22 SP - 1416 EP - 1416 SN - 0028-4793 AD - Sarin, P. S.: National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862027692. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health N2 - The authors produce evidence based on inhibition of replication in H9 cells to show that the laboratory disinfectant LDtm (Alcide, Norwalk, Connecticut, USA) is an effective inactivator of HTLV-III/LAV. The product releases chlorous acid and subsequently chlorine dioxide. The results based on the average of 4 experiments indicate complete inactivation of the virus when used at a dilution of 1 in 200 of its standard-use dilution. The authors suggest the product would be useful in hospitals and clinical laboratories.A.E. Wright KW - acquired immune deficiency syndrome KW - Disinfectants KW - human immunodeficiency viruses KW - inactivation KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - HTLV-III inactivation KW - human immunodeficiency virus KW - laboratory disinfectant KW - LDtm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027692&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex. AU - Resnick, L. AU - DiMarzo Veronese, F. AU - et al. AU - Schüpbach, J. ( AU - Gallo, R. C. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1985/// VL - 313 IS - 24 SP - 1498 EP - 1504 SN - 0028-4793 AD - Resnick, L.: (R.C. Gallo) Bldg 37, Rm 6A09, National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862029641. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors examined the cerebrospinal fluid (CSF) and serum of patients with AIDS-related neurological syndromes for the presence of specific anti-HTLV-III/LAV antibodies by fixed-cell immunofluorescence, ELISA, immunoblot and radioimmunoprecipitation. 22 of 23 had specific antibodies in the CSF and unique oligoclonal bands were demonstrated. Furthermore, the percentage of HTLV-III/LAV-specific IgG in CSF was higher than in serum and the rate of IgG synthesis within the blood-brain barrier was elevated. [See abstracts above and below.]I.V.D. Weller KW - acquired immune deficiency syndrome KW - brain KW - clinical aspects KW - human immunodeficiency viruses KW - nervous system KW - patients KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cerebrum KW - clinical picture KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029641&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The AIDS problem in Africa. AU - Biggar, R. J. JO - Lancet JF - Lancet Y1 - 1986/// VL - i SP - 79 EP - 83 AD - Biggar, R. J.: International AIDS Epidemiology, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MA 20205, USA. N1 - Accession Number: 19862027259. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Public Health; Tropical Diseases N2 - A valuable review of existing knowledge and of the relevance of studies of AIDS in Africa to the disease elsewhere. KW - acquired immune deficiency syndrome KW - epidemiology KW - Africa KW - AIDS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027259&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treponematoses and tropical spastic paraparesis. AU - Rodgers-Johnson, P. AU - Morgan, O. St. C. AU - et al. AU - Zaninovic, V. ( JO - Lancet JF - Lancet Y1 - 1986/// VL - i IS - Apr. 5 SP - 809 EP - 809 AD - Rodgers-Johnson, P.: Laboratory of Central Nervous System Studies, NINCDS, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862028674. Publication Type: Journal Article. Subject Subsets: Tropical Diseases N2 - It is unfortunate that the authors of this letter decided to dispense with a control population when presenting data of antibodies against treponemes and borrelia in sera taken from cases of tropical spastic paraparesis seen in Jamaica and Colombia. A high incidence (11 of 24 Jamaican samples) of positive syphilitic tests in this condition has been previously recorded. The presence of Lyme antibodies detected by an IFA-ABS test in 6 of 24 Jamaican samples is not surprising as the significant titre was taken as 1 in 5 which in my experience would include a large segment of the normal population. The most surprising finding is the presence of HTLV-I antibodies in serum and cerebrospinal fluid detected by enzyme-linked immunosorbent assay in both groups of patients. The relationship between these antibody findings and the clinical disease remains speculative.D.J.M. Wright KW - acquired immune deficiency syndrome KW - antibodies KW - HTLV infections KW - Lyme disease KW - patients KW - treponematosis KW - Tropical spastic paraparesis KW - Caribbean KW - Colombia KW - Jamaica KW - South America KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Andean Group KW - Latin America KW - South America KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - AIDS HTLV-I serology KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - lyme borreliosis KW - treponemes and HTLV-I KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028674&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term use of oral contraceptives and risk of invasive cervical cancer. AU - Brinton, L. A. AU - Huggins, G. R. AU - et al. AU - Lehman, H. F. ( JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1986/// VL - 38 IS - 3 SP - 339 EP - 344 SN - 0020-7136 AD - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm. 3C06, Bethesda, MD 20892, USA. N1 - Accession Number: 19862034114. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A study in 5 regions of the USA revealed, after control for interval since last Pap smear, an increased risk of invasive cervical cancer among long-term users of oral contraceptives.D.W. FitzSimons KW - cervix KW - contraceptives KW - Family planning KW - female genitalia KW - genitalia KW - mouth KW - neoplasms KW - oral contraceptives KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - female genital system KW - long-term use KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Fertility (UU250) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862034114&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mosses, liverworts, and hornworts screened for antitumor agents. AU - Spjut, R. W. AU - Suffness, M. AU - Cragg, G. M. AU - Norris, D. H. JO - Economic Botany JF - Economic Botany Y1 - 1986/// VL - 40 IS - 3 SP - 310 EP - 338 SN - 0013-0001 AD - Spjut, R. W.: Natural Products Branch, National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19860340790. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Horticultural Science; Weeds N2 - The methods used by the National Cancer Institute in collecting and prescreening bryophytes are reviewed, and screening data are discussed for species that showed significant biological activity in bioassays. Results are summarized in a table listing species alphabetically by family and by genus. Extracts of 75 species were cytotoxic and those of 43 (mostly different) species showed antitumour activity. KW - composition KW - medicinal plants KW - Medicinal properties KW - utilization KW - Weeds KW - USA KW - Bryophyta KW - plants KW - plants KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - drug plants KW - medicinal herbs KW - officinal plants KW - United States of America KW - Plant Composition (FF040) KW - Weeds and Noxious Plants (FF500) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19860340790&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS. AU - Starcich, B. R. AU - Hahn, B. H. AU - et al. AU - Shaw, G. M. ( JO - Cell JF - Cell Y1 - 1986/// VL - 45 IS - 5 SP - 637 EP - 648 AD - Starcich, B. R.: Laboratory of Tumor Cell Biology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205, USA. N1 - Accession Number: 19862031999. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors analysed the nucleotide and deduced amino acid sequences of the complete envelope genes and part of the gag and pol genes for HTLV-III isolates from 2 Haitian patients with AIDS. Comparison with published sequences for 3 other isolates revealed extensive variation throughout the genome, in particular in the envelope gene. Interspersed within the variable regions were highly conserved areas. Hypervariable regions appear to represent potential antigenic sites. Types of mutation differed in the env and gag genes. The rate of genetic change for the env gene is at least 10-3 nucleotide substitutions per site per year, similar to that of influenza A virus.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - analysis KW - Evolution KW - genomes KW - human immunodeficiency viruses KW - Structure KW - Virology KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - envelope genes KW - HTLV-BLV group KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031999&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. AU - Harper, M. E. AU - Marselle, L. M. AU - Gallo, R. C. AU - Wong-Staal, F. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1986/// VL - 83 IS - 3 SP - 772 EP - 776 SN - 0027-8424 AD - Harper, M. E.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862029162. Publication Type: Journal Article. Subject Subsets: Public Health N2 - The authors used in situ hybridization to examine directly primary lymph node and peripheral blood from patients with AIDS and AIDS-related complex for the presence of HTLV-III RNA. Mononuclear cell preparations were hybridized with a 35S-labelled HTLV-III-specific RNA probe and exposed to autoradiographic emulsion for 2 days. HTLV-III-infected cells expressing viral RNA were detected in 6 of 7 lymph node and 7 of 14 peripheral blood samples studied, but in all samples examined labelled cells were observed at very low frequency (<0.01% of total mononuclear cells). Viral RNA was expressed at relatively low abundance (20-300 copies per cell). The morphology of infected cells was consistent with that of lymphocytes. "These results demonstrate that HTLV-III expression in lymph node and peripheral blood is very low in vivo. Furthermore, the lymph node hyperplasia observed in HTLV-III-associated lymphadenopathy is not directly due to proliferation of HTLV-III-infected lymphocytes."D.W. FitzSimons KW - Acquired immune deficiency syndrome KW - detection KW - human immunodeficiency viruses KW - in situ hybridization KW - pathology KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - lymphocyte detection KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029162&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. AU - Mitsuya, H. AU - Broder, S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1986/// VL - 83 IS - 6 SP - 1911 EP - 1915 SN - 0027-8424 AD - Mitsuya, H.: Clinical Oncology Program, Building 10, Room 6B15, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862030690. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors investigated the activity of 9 purine and pyrimidine nucleoside analogues using HTLV-IIIB in an OKT4+ T-cell clone. Five 2′,3′-dideoxy compounds protected the T-cells against the cytopathic effect of the virus at 0.5-10 µmol/l (although the thymidine derivative was less active). These concentrations were 10-20 times lower than those that inhibited growth of cells in the absence of virus. The adenosine, guanosine, inosine and cytidine analogues all inhibited expression of the p24 gag protein at 10 µmol/l; the thymidine compound needed higher concentrations and allowed a resumption of viral replication after 10 days. Taking adenosine, the authors then investigated 5 derivatives that varied in the sugar group; only the 2′,3′-dideoxy compound completely protected the target cells against lysis by the virus and even the 2′,3′,5′-trideoxy compound failed to inhibit the cytopathic effect (presumably because of its inability to undergo phosphorylation). These 2′,3′-dideoxy compounds left the in vitro immune reactivity of normal T cells basically intact. Their mechanism of action is not known.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - Antiviral agents KW - dideoxynucleosides KW - human immunodeficiency viruses KW - inhibition KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862030690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Three novel genes of human T-lymphotropic virus type III: immune reactivity of their products with sera from acquired immune deficiency syndrome patients. AU - Arya, S. K. AU - Gallo, R. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1986/// VL - 83 IS - 7 SP - 2209 EP - 2213 SN - 0027-8424 AD - Arya, S. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862031662. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The open reading frames sor, tat and 3′ orf were characterized. The genes synthesize polypeptides with apparent mobilities of Mr 23-24 000, 14-15 000 and 26-28 000, respectively all of which are immunogenic in vivo. Sera from AIDS and ARC patients immune precipitated the 3 gene products, particularly that of the 3′ orf gene. Some normal human sera reacted weakly with the sor gene product.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - Genetics KW - human immunodeficiency viruses KW - Molecular biology KW - open reading frames KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - ORFs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy. AU - Stoner, G. L. AU - Ryschkewitsch, C. F. AU - Walker, D. L. AU - Webster, H. de F. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1986/// VL - 83 IS - 7 SP - 2271 EP - 2275 SN - 0027-8424 AD - Stoner, G. L.: Laboratory of Experimental Neuropathology, National Institute of Neurological and Communicative Disorders and Stroke, Building 9, Room 1E-127, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862031664. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Progressive multifocal leukoencephalopathy (PML) is a JC papovavirus infection of the central nervous system in immunocompromised patients. It is well established that demyelination in PML is caused by JC virus infection of oligodendroglia, but whether the nonstructural regulatory protein, large tumor (T) antigen, is detectable in infected human tissue was not known. Using a modification of the peroxidase-antiperoxidase technique, [the authors] found T antigen expressed in the nuclei of cells in virus-infected sites in five cases of PML studied, including two with acquired immune deficiency syndrome (AIDS). PML occurs in AIDS at a much higher frequency than in other immunosuppressive disorders, and PML in AIDS may represent a more severe form of JC virus infection of the central nervous system.AS KW - acquired immune deficiency syndrome KW - antigens KW - patients KW - progressive multifocal leukoencephalopathy KW - JC polyomavirus KW - Polyomavirus KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - AIDS KW - antigenicity KW - brain tissue KW - immunogens KW - JC polyomaviruses KW - JC virus KW - leukoencephalopathy KW - T KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031664&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I. AU - Matsushita, S. AU - Robert-Guroff, M. AU - Trepel, J. AU - Cossman, J. AU - Mitsuya, H. AU - Broder, S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1986/// VL - 83 IS - 8 SP - 2672 EP - 2676 SN - 0027-8424 AD - Matsushita, S.: Clinical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862031235. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors report the production of monoclonal antibody to an envelope glycoprotein of HTLV-I by B cells removed from the lymph node of a patient with adult T-cell leukaemia, transformed by Epstein-Barr virus and cloned by limiting dilution. The clones obtained were expanded and screened for anti-HTLV-I activity to enable an anti-HTLV-I env monoclonal antibody producing clone (designated 0.5 α) to be identified.[The production of immune monoclonal anti-HTLV-I env has proved difficult and for this and other reasons this work is notable. It also suggests a strategy for preparing human monoclonal antibodies that may have wider diagnostic and therapeutic applications.]P. Mortimer KW - acquired immune deficiency syndrome KW - glycoproteins KW - monoclonal antibodies KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - envelope KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia. AU - Kovacs, J. A. AU - Gill, V. AU - Swan, J. C. JO - Lancet JF - Lancet Y1 - 1986/// VL - ii IS - July 5 SP - 1 EP - 3 AD - Kovacs, J. A.: Depts of Critical Care Medicine and Microbiology, Clinical Center, National Institutes of Health, Bethesda, MA, USA. N1 - Accession Number: 19862031255. Publication Type: Journal Article. Subject Subsets: Public Health N2 - The authors used a mouse monoclonal antibody 2G2 directed against human Pneumocystis carinii in an indirect immunofluorescent assay to evaluate its diagnostic potential in clinical specimens. Of 25 bronchoscopy specimens obtained from AIDS patients over a 3-month period, 14 were positive for P. carinii by toluidine-blue-O stain. 13 of these were positive by immunofluorescence, with more than one clump of organisms being seen usually within the first minute. In the one false-negative case the organism was seen only rarely by staining and the specimen had been taken from a patient after 5 weeks of treatment for P. carinii pneumonia. None of the 11 stain-negative specimens was positive by immunofluorescence. Two impression smears of histologically negative open-lung biopsy specimens were also negative but both of two impression smears of histologically positive necropsy specimens were positive. "Immunofluorescence with monoclonal antibody 2G2 is a rapid, simple, and specific technique for detection of P. carinii in clinical specimens."D.W. FitzSimons KW - acquired immune deficiency syndrome KW - clinical aspects KW - Diagnosis KW - Immunodiagnosis KW - immunofluorescence KW - monoclonal antibodies KW - Opportunistic infections KW - Pneumocystis carinii pneumonia KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis KW - Pneumocystis carinii KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Pneumocystis KW - AIDS KW - clinical picture KW - fluorescent antibody technique KW - fungus KW - IFAT KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031255&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men. AU - Masur, H. AU - Lane, C. AU - et al. AU - Palestine, A. ( JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1986/// VL - 104 IS - 1 SP - 41 EP - 44 SN - 0003-4819 AD - Masur, H.: Clinical Center, Building 10, Rm 10D-48, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862027835. Publication Type: Journal Article. Language: English. Registry Number: 82410-32-0. Subject Subsets: Public Health N2 - This important paper reports a pilot study of the treatment of serious cytomegalovirus (CMV) infection in 8 patients with AIDS-7 with retinitis (1 with colitis as well) and 1 with pneumonitis alone. All 8 patients responded partially or completely but all relapsed within 30 days of cessation of treatment. Six surviving patients were then treated and 5 showed a clinical response to the second course. Maintenance regimens using 2.5 mg/kg for 3 to 5 doses a week had to be stopped because of leukopenia. This small series seems to establish, as appears generally acknowleged in the USA, that relapse of CMV infection in AIDS after treatment with dihydroxypropoxymethylguanine (DHPG) is almost inevitable unless maintenance regimens are used. [Too few patients, however, were tried on maintenance in this series to evaluate it as a reasonable therapeutic manoeuvre. (Syntex, a manufacturer of DHPG, reports that 5 doses per week are necessary for successful maintenance and not all patients become leukopenic on this dose.)]Charles Farthing KW - acquired immune deficiency syndrome KW - ganciclovir KW - infections KW - medical treatment KW - treatment KW - viral diseases KW - USA KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cytomegalovirus infection with AIDS KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862027835&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Suramin and function of the adrenal cortex. AU - Stein, C. A. AU - Saville, W. AU - Yarchoan, R. AU - Broder, S. AU - Gelmann, E. P. T2 - Annals of Internal Medicine JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1986/// VL - 104 IS - 2 SP - 286 EP - 287 SN - 0003-4819 AD - Stein, C. A.: National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862028935. Publication Type: Correspondence. Language: English. Registry Number: 145-63-1. Subject Subsets: Public Health N2 - A patient with AIDS and Kaposi's sarcoma was treated with suramin, eventually at a maintenance dose of 1100 mg/m² (12.4 g) every 2 weeks whereupon he developed profound hyproadrenalism. (The authors do not exclude other possible causes such as overwhelming cytomegalovirus infection.)D.W. FitzSimons KW - acquired immune deficiency syndrome KW - Kaposi's sarcoma KW - medical treatment KW - suramin KW - treatment KW - AIDS KW - hypoadrenalism KW - Kaposi's sacoma KW - reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities. AU - Melbye, M. AU - Biggar, R. J. AU - et al. AU - Ebbesen, P. ( JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1986/// VL - 104 IS - 4 SP - 496 EP - 500 SN - 0003-4819 AD - Melbye, M.: Environmental Epidemiology Branch, National Cancer Institute, Landow Building 3C19; Bethesda, MD 20892, USA. N1 - Accession Number: 19862030056. Publication Type: Journal Article. Subject Subsets: Public Health N2 - The natural history of HIV infection in 250 homosexual men in Denmark was studied by repeated serological testing since 1981. Serum samples were taken initially, then in 1982, 1983 and in 1984, when 134 individuals could be re-tested for HIV antibody and T-lymphocyte subsets studies. Initially 8.8% were HIV antibody positive. Seroconversion rate was 0.53% per month and by 1984 26.1% of those tested were HIV antibody positive. The presence of HIV antibody was associated with the number of sexual partners, increased frequency of receptive anal intercourse and use of nitrite inhalants. T-lymphocyte subsets were determined in 50 individuals, 19 of whom were HIV antibody positive. Sixteen of these 19 men had inverted T4/T8 ratios compared with 4 of the 31 seronegative men. Subjects who had been seropositive for the longest period of time had the lowest ratios. Clinically, lymphadenopathy was significantly associated with seropositivity both short- and long-term, whereas diarrhoea, oral thrush and herpes zoster were associated with long-term seropositivity only. Half the long-term seropositive men developed symptoms compared with 29% of the short-term and 16% of the seronegative group. Lymphadenopathy developed relatively early but persistent constitutional symptoms appeared later. It is as yet not known whether the patients with symptoms will develop AIDS or return to normal but the number of T-helper cells is considered to be a valuable predictor of the future development of AIDS.G.W. Csonka KW - acquired immune deficiency syndrome KW - antibodies KW - clinical aspects KW - HIV infections KW - homosexuality KW - HTLV infections KW - human immunodeficiency viruses KW - Immunology KW - men KW - Serology KW - Denmark KW - Europe KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - AIDS KW - clinical picture KW - homosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - long-term seropositivity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862030056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV. AU - Folks, T. AU - Kelly, J. AU - et al. AU - Benn, S. ( JO - Journal of Immunology JF - Journal of Immunology Y1 - 1986/// VL - 136 IS - 11 SP - 4049 EP - 4053 AD - Folks, T.: National Institutes of Health, Building 10, Room, 11B-13, Bethesda, MD 20892, USA. N1 - Accession Number: 19862033738. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Peripheral blood lymphocytes from all 10 healthy volunteers tested became infected and produced virus (as detected by reverse transcriptase activity) after pretreatment with phytohaemagglutinin (PHA) and incubation with HIV. The donors could be grouped into consistently high (3 individuals) or low producers of reverse transcriptase activity. The kinetics of virus production was similar for the 2 groups. Mitogen (PHA)-activated lymphocytes showed signs of infection earlier than untreated cells, and untreated cells did not show detectable reverse transcriptase activity. Reverse transcriptase activity correlated positively with the proportion of Leu 3+ cells in the lymphocyte sample. Addition of anti-human interferon-α to the cells did not affect virus production.The authors comment that the opportunistic infections in AIDS patients could result in activated T cells which would then accelerate the progress of the disease by allowing greater production of HIV.Carolyn A. Brown KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - Immunology KW - infections KW - lymphocytes KW - Opportunistic infections KW - Susceptibility KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862033738&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serological characterization of human T-cell leukemia (lymphotropic) virus, type I (HTLV-I) small envelope protein. AU - Newman, M. J. AU - Baker, I. T. AU - et al. AU - Reitz, M. S. ( AU - Mann, D. L. JO - Virology JF - Virology Y1 - 1986/// VL - 150 IS - 1 SP - 106 EP - 116 AD - Newman, M. J.: (D.L. Mann) Lab. of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA. N1 - Accession Number: 19862030116. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - acquired immune deficiency syndrome KW - characterization KW - envelope proteins KW - Virology KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862030116&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enzyme immunoassay detection of immunoglobulin M and G antibodies to Cryptosporidium in immunocompetent and immunocompromised persons. AU - Ungar, B. L. P. AU - Soave, R. AU - Fayer, R. AU - Nash, T. E. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1986/// VL - 153 IS - 3 SP - 570 EP - 578 SN - 0022-1899 AD - Ungar, B. L. P.: Building 5, Rm 112, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA. N1 - Accession Number: 19862031280. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 308067-57-4. Subject Subsets: Protozoology; Public Health N2 - The authors developed a sensitive, reproducible, enzyme-linked immunoassay (ELISA) for the detection of Cryptosporidium spp. IgG and IgM, using oocysts from experimentally infected calves as the antigen source. Sensitivity and specificity were 95% both in patients with and those without underlying AIDS. Thirteen of 15 immunocompetent people with cryptosporidiosis and all 26 AIDS sufferers with cryptosporidiosis were positive for IgG; 57 of 60 (18 with AIDS) who were not infected with Cryptosporidium were negative for IgG and the 3 who were positive might well have been exposed previously to infection (details given in text). All patients with AIDS produced IgG and some produced IgM; those without AIDS showed an early rise and fall in IgM and a later elevation of IgG. Nine (21%) of 44 Ecuadorian children with diarrhoea had a positive serological response for both IgM and IgG antibodies; serum samples from 106 people with other parasitic diseases (details given in text) gave a normal distribution for IgG antibody. [The authors consider that this will form a useful adjunct in the clinical diagnosis of cryptosporidiosis, in epidemiological screening, in a research setting and also in defining the humoral immune response to this infection.]G.C. Cook<new para>ADDITIONAL ABSTRACT:<new para>A sensitive and reproducible enzyme immunoassay for detection of serum IgG or IgM to Cryptosporidium was developed. For IgG, 13 of 15 patients with cryptosporidiosis and 26 of 26 patients with cryptosporidiosis and AIDS were positive, whereas 57 of 60 presumably uninfected individuals were negative. All 3 IgG-positive presumably uninfected individuals had been potentially exposed. Sensitivity and specificity of this assay were 95%. Patients without AIDS showed an early rise and fall of IgM and later elevation of IgG; some patients with AIDS produced IgM, and all produced IgG. Sera from 9 of 44 Ecuadorian children which diarrhoea were positive for both IgM and IgG antibodies; 106 sera from persons with other parasitic illnesses showed a normal distribution for IgG antibody. These ELISA data show that patients without and with AIDS have serum antibody response to Cryptosporidium and suggest that exposure to or infection with Cryptosporidium is common. KW - acquired immune deficiency syndrome KW - Cryptosporidiosis KW - Diagnosis KW - ELISA KW - Immunodiagnosis KW - Immunoglobulins KW - Immunology KW - Opportunistic infections KW - parasites KW - Serology KW - Ecuador KW - Cryptosporidium KW - man KW - protozoa KW - Cryptosporidiidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - AIDS KW - enzyme linked immunosorbent assay KW - gamma-globulins KW - immune globulins KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031280&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The slow, insidious natures of the HTLV's. AU - Marx, J. L. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 231 SP - 450 EP - 451 AD - Marx, J. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862028459. Publication Type: Journal Article. Subject Subsets: Public Health N2 - Cells of the human T-cell line A3.O1 consist of 2 populations, one with the Leu-3 surface marker (Leu+) and the other without (Leu-). This report describes the persistence of HTLV-III in the Leu- cells and the subsequent induction of infectious virus by treatment with 5-iodo-2′-deoxyuridine.R.N.P. Sutton KW - acquired immune deficiency syndrome KW - chronic infections KW - culture techniques KW - human immunodeficiency viruses KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - Leu cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028459&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera. AU - Kan, N. C. AU - Franchini, G. AU - et al. AU - Wong-Staal, F. ( AU - Papas, T. S. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 231 IS - Mar. 28 SP - 1553 EP - 1555 AD - Kan, N. C.: (T.S. Papas) Lab. of Molecular Oncology, National Cancer Institute, National Institutes of Health, Frederick, MD 21701-1013, USA. N1 - Accession Number: 19862029523. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Escherichia coli synthesized a protein of Mr 23 000 (p23, see above) from DNA containing 82% of the sor region of HTLV-III inserted into an expression vector. Sera from some (32-54%) AIDS and ARC patients and healthy subjects at risk of AIDS as well as some healthy donors (25%) reacted with the purified protein, believed to be the sor gene product.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - genomes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus KW - sor gene product KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029523&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression. AU - Green, W. C. AU - Leonard, W. J. AU - et al. AU - Wano, Y. ( JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 232 IS - May 16 SP - 877 EP - 880 AD - Green, W. C.: Metabolism Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862031963. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line resulted in the induction of both interleukin-2 receptor and interleukin-2 gene expression. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Genetics KW - Immunology KW - Deltaretrovirus KW - Human T-cell lymphotropic virus KW - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE II KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - HTLV-BLV group KW - trans-activator gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neutralization of HTLV-III/LAV replication by antiserum to thymosin α1. AU - Sarin, P. S. AU - Sun, D. K. AU - Thornton, A. H. AU - Naylor, P. H. AU - Goldstein, A. L. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 232 IS - May 30 SP - 1135 EP - 1137 AD - Sarin, P. S.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862031974. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - An antiserum prepared against thymosin α1, a hormone secreted by the thymus gland, effectively neutralized the AIDS-associated virus [HTLV-III/LAV(clone BH-10)] and blocked its replication in H9 cells. Reverse transcriptase activity and expression of the HTLV-III/LAV antigens p15 and p24 were inhibited by purified immunoglobulin G preparations of antisera to thymosin α1. The antiviral activity of the antiserum was found to be due to a region of homology between thymosin α1 and p17, a product of the gag gene of HTLV-III/LAV. Comparison of the primary sequences of thymosin α1 and the gag protein revealed a 44% to 50% homology in an 18-amino acid region, between positions 11 and 28 on thymosin α1 and 92 and 109 on the gag protein. The effectiveness of the thymosin α1 antiserum and of immunoglobulin G-enriched preparations in blocking replication of HTLV-III(BH-10) in H9 cells suggests a novel approach to the development of an AIDS vaccine. A vaccine directed against the gag protein might overcome the problem of genetic drift in the envelope region of the virus and be useful against all genetic variants of HTLV-III/LAV.AS KW - acquired immune deficiency syndrome KW - Control KW - human immunodeficiency viruses KW - Molecular biology KW - neutralization KW - Replication KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - thymosin alpha1 antiserum KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes. AU - Waldmann, T. A. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 232 IS - May 9 SP - 727 EP - 732 AD - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862031959. Publication Type: Journal Article. Language: English. Registry Number: 102524-44-7, 85898-30-2. Subject Subsets: Public Health N2 - Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33 000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55 000-dalton form. In contrast to resting T cells, human T-cell lymphotropic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.AS KW - acquired immune deficiency syndrome KW - Immunology KW - interleukin 2 KW - medical treatment KW - receptors KW - treatment KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031959&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Replication of the B19 parvovirus in human bone marrow cell cultures. AU - Ozawa, K. AU - Kurtzman, G. AU - Young. N. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 233 IS - Aug. 22 SP - 883 EP - 886 AD - Ozawa, K.: ACRF 7C108, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862034105. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - culture techniques KW - Parvoviridae KW - parvovirus B19 KW - ssDNA viruses KW - DNA viruses KW - viruses KW - Parvovirus KW - Parvoviridae KW - human bone marrow cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862034105&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of mononuclear phagocytes in HTLV-III/LAV infection. AU - Gartner, S. AU - Markovits, P. AU - Markovitz, D. M. AU - Kaplan, M. H. AU - Gallo, R. C. AU - Popovic, M. JO - Science, USA JF - Science, USA Y1 - 1986/// VL - 233 IS - July 11 SP - 215 EP - 219 AD - Gartner, S.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862032032. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - "Cells with properties characteristic of mononuclear phagocytes were evaluated for infectivity with five different isolates of the AIDS virus, HTLV-III/LAV. Mononuclear phagocytes cultured from brain and lung tissues of AIDS patients harbored the virus. In vitro-infected macrophages from the peripheral blood, bone marrow, or cord blood of healthy donors produced large quantities of virus. Virus production persisted for at least 40 days and was not dependent on host cell proliferation. Giant multinucleated cells were frequently observed in the macrophage cultures and numerous virus particles, often located within vacuole-like structures, were present in infected cells. The different virus isolates were compared for their ability to infect macrophages and T cells. Isolates from lung- and brain-derived macrophages had a significantly higher ability to infect macrophages than T cells. In contrast, the prototype HTLV-IIIB showed a 10 000-fold lower ability to infect macrophages than T cells and virus production was one-tenth that in macrophage cultures infected with other isolates, indicating that a particular variant of HTLV-III/LAV may have a preferential tropism for macrophages or T cells. These results suggest that mononuclear phagocytes may serve as primary targets for infection and agents for virus dissemination and that these virus-infected cells may play a role in the pathogenesis of the disease."[This report and an earlier one (see Lifson et al. above) emphasize the importance of the CD4 antigen in the infection of cells by HIV. Further, it is evident that the characteristic giant cell (syncytium) formation in some tissues in AIDS patients could arise from fusion of either T cells or macrophages.]S.B. Lucas KW - acquired immune deficiency syndrome KW - CD4 antigens KW - cells KW - HIV infections KW - human immunodeficiency viruses KW - infection KW - Macrophages KW - receptors KW - T lymphocytes KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - CD4 KW - Cytopathology KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862032032&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence of antibodies to HTLV-I, -II, and -III in intravenous drug abusers from an AIDS endemic region. AU - Robert-Guroff, M. AU - Weiss, S. H. AU - et al. AU - Giron, J. A. ( JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1986/// VL - 255 IS - 22 SP - 3133 EP - 3137 AD - Robert-Guroff, M.: National Cancer Institute, National Institutes of Health, Bldg 37, Room 6A09, Bethesda, MD 20892, USA. N1 - Accession Number: 19862031920. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Antibody prevalences for human T-cell lymphotropic virus (HTLV) types I, II, and III were determined for 56 intravenous drug abusers from Queens, NY. While control serum samples lacked antibodies to all HTLV subgroups, seropositivity among drug users was 41% for HTLV-III, 18% for HTLV-II, and 9% for HTLV-I. Infection by HTLV-I and -II occurred independently of HTLV-III infection. Blacks had greater HTLV-III antibody prevalence than whites (54% vs 16%) and were more likely than whites to be seropositive for HTLV-I or -II (46% vs 11%). They exhibited a greater incidence than whites of double infection with HTLV-I or -II and HTLV-III (27% vs 0%), and 73% were seropositive for at least one of the viruses, compared with only 26% of the whites. The increased HTLV-I and -II infection seen in intravenous drug users suggests that once introduced into a population, these viruses may be transmitted by the same routes as HTLV-III. Transmission may have been restricted mainly to blacks in this study because of local drug use practices.[The subjects consisted of 2 groups: 25 drug users with various soft-tissue infections and 31 individuals undergoing drug detoxification without such infections. Samples of sera from the latter were collected in 1981 and 1982 and frozen until assay. Sera that were positive by ELISA were confirmed in competition assays or a modified Western blot for HTLV-III. With regard to the prevalence of HTLV-I infection the authors note a recent report of a cluster of cases of adult T-cell leukaemia in Brooklyn, N.Y., and point out the longer latency period for that disease than for AIDS and HTLV-III infections.]AS/D. W. FitzSimons KW - acquired immune deficiency syndrome KW - Drug abuse KW - drug users KW - HTLV infections KW - human immunodeficiency viruses KW - serological surveys KW - New York KW - North America KW - USA KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - human T-cell lymphotropic virus type II KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Human T-cell lymphotropic virus KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - drug abusers KW - drug use KW - HTLV-BLV group KW - HTLV-II and HTLV-III KW - human immunodeficiency virus KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - seroepidemiology KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862031920&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The natural history of human T lymphotropic virus-III infection: the cause of AIDS. AU - Melbye, M. JO - British Medical Journal JF - British Medical Journal Y1 - 1986/// VL - 292 SP - 5 EP - 12 AD - Melbye, M.: Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Landow Building 3C19, Bethesda, MD 20892, USA. N1 - Accession Number: 19862026964. Publication Type: Journal Article. Language: English. Number of References: 134 ref. Subject Subsets: Public Health KW - HIV infections KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026964&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnosis of Creutzfeldt-Jakob disease by Western blot identification of marker protein in human brain tissue. AU - Brown, P. AU - Coker-Vann, M. AU - et al. AU - Pomeroy, K. ( JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1986/// VL - 314 IS - 9 SP - 547 EP - 551 SN - 0028-4793 AD - Brown, P.: Bldg 36, Rm 5B05, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862029049. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The discovery of a fibrillary structure that contains a characteristic group of protease-resistant proteins in brain-tissue preparations from animals with scrapie and humans with Creutzfeldt-Jakob disease (CJD) has, as the authors state, "opened the door to an immunologic approach to the diagnosis of these diseases". Using the Western blot technique (details given), 75% of (4) kuru specimens were positive, as were 81% of those from 31 patients with CJD and 75% of brain specimens from 4 patients with the Gerstmann-Sträussler-Scheinker syndrome (which clinically may resemble CJD). Control specimens included brains from patients with a range of other conditions (Alzheimer's disease, AIDS encephalopathy, and other dementias) which clinically resembled CJD and where tissue had been submitted for a full range of investigation, including primate inoculation; all were negative.[This important paper indicates that Alzheimer's disease is, in all probability, not associated with infection by an agent similar to that responsible for CJD, a finding consistent with the unsuccessful attempts to transmit Alzheimer's disease to primates by inoculation.]R.N.P. Sutton KW - diagnosis KW - Immunodiagnosis KW - Kuru KW - AIDS encephalopathy pathology KW - Creuzfeld-Jakob disease KW - serological diagnosis KW - Western blot technique KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862029049&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. AU - Chakrabarti, S. AU - Robert-Guroff, M. AU - Wong-Staal, F. AU - Gallo, R. C. AU - Moss, B. JO - Nature, UK JF - Nature, UK Y1 - 1986/// VL - 320 IS - Apr. 10 SP - 535 EP - 537 AD - Chakrabarti, S.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19862028917. Publication Type: Journal Article. Subject Subsets: Public Health N2 - The env protein of HTLV-III can induce protective immunity in mice and is therefore of potential value in the construction of a vaccine against this virus. This report describes the preparation of an infectious recombinant vaccinia virus which contained this gene. Full details are given which show that this recombinant effectively synthesized the env protein without any other HTLV-III functions and that it was immunogenic in mice. (An addendum notes that 7 of 8 primates (Macaca fascicularis) immunized with the recombinant developed antibodies to the env protein.)[Clearly this is an important step forward in the control of AIDS.]R.N.P. Sutton KW - acquired immune deficiency syndrome KW - HTLV infections KW - human immunodeficiency viruses KW - immunization KW - recombination KW - mice KW - Vaccinia virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - AIDS KW - AIDS vaccine animal KW - genetic recombination KW - HTLV-III envelope gene KW - human immunodeficiency virus KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - immune sensitization KW - recombinant vaccinia virus with HTLV-III gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028917&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The trans-activator gene of HTLV-III is essential for virus replication. AU - Fisher, A. G. AU - Feinberg, M. B. AU - et al. AU - Josephs, S. F. ( JO - Nature, UK JF - Nature, UK Y1 - 1986/// VL - 320 IS - Mar. 27 SP - 367 EP - 371 AD - Fisher, A. G.: Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20205, USA. N1 - Accession Number: 19862028719. Publication Type: Journal Article. Subject Subsets: Public Health N2 - Trans-activator genes have been found in human and animal retroviruses; these specifically augment expression of viral genes. Structural studies of HTLV-III have identified a trans-activated gene (tat-III) in addition to 5 previously known genes (gag, pol, sor, env and 3′orf). In this report derivatives of an HTLV-III clone in which tat-III had been deleted failed to produce the usual levels of virus when transfected into T-cell cultures. This observation that the tat-III gene is critical for HTLV-III replication suggests that the development of inhibitors that could specifically block the activity of these trans-acting factors may provide a new approach to the treatment of AIDS patients.[Further complex analysis of the HTLV-III genome may lead to effective therapy.]R.N.P. Sutton KW - acquired immune deficiency syndrome KW - genes KW - Genetics KW - human immunodeficiency viruses KW - replication KW - transactivation KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - AIDS KW - HTLV-BLV group KW - human immunodeficiency virus KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028719&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - First isolation of HTLV-III. AU - Gallo, R. C. AU - Sarin, P. S. AU - Kramarsky, B. AU - Salahuddin, Z. AU - Markham, P. AU - Popovic, M. T2 - Nature, UK JO - Nature, UK JF - Nature, UK Y1 - 1986/// VL - 321 IS - May 8 SP - 119 EP - 119 AD - Gallo, R. C.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19862030709. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health N2 - The history of the early studies on transmission of HTLV-III/LAV is explained and the chronology of isolations of the virus from 10 patients with AIDS or ARC (including 3 French patients) from December 1982 to April 1984 is summarized. [This strengthens Gallo's argument for prior discovery, an important issue in view of the patent rights (see p. 102).]D.W. FitzSimons KW - acquired immune deficiency syndrome KW - history KW - HTLV infections KW - human immunodeficiency viruses KW - transmission KW - France KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Western Europe KW - Europe KW - APEC countries KW - North America KW - America KW - AIDS KW - human immunodeficiency virus KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - History and Biography (BB500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862030709&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine. AU - Good, M. F. AU - Berzofsky, J. A. AU - Maloy, W. L. AU - Hayashi, Y. AU - Fujii, N. AU - Hockmeyer, W. T. AU - Miller, L. H. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1986/// VL - l64 IS - 2 SP - 655 EP - 660 SN - 0022-1007 AD - Good, M. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19860199422. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Animal Breeding; Protozoology N2 - H-2-congenic strains of mice were immunized with a Plasmodium falciparum sporozoite vaccine, or with different segments of the vaccine molecule. Specific IgG production or lymph node cell proliferation in response to different antigens was then determined. Only 4 of 7 strains (representing 3 of 8 possible MHC class-II restriction molecules) responded to the vaccine. Of the restriction molecules, only one (I-Ab) was associated with a response to Plasmodium-encoded T epitope, while the other 2 molecules (EαdEβd and EαkEβs) were associated with a T-cell response to a non-malarial epitope(s) carboxyterminal to the Plasmodium sequence, and encoded by a tetracycline resistance gene, read out of frame. The immune response to the T-cell epitopes was under Ir gene control, and mapped to the I-A and I-G regions of the H-2 complex. KW - Genes KW - genetics KW - histocompatibility KW - hosts KW - immune response KW - immunization KW - Immunogenetics KW - immunology KW - Laboratory animals KW - molecular genetics KW - parasites KW - mice KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - biochemical genetics KW - H-2 complex KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - Plasmodium falciparum vaccine KW - sporozoite vaccine KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19860199422&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antigenic variation and antigenic diversity in malaria. AU - Howard, R. J. JO - Contributions to Microbiology and Immunology JF - Contributions to Microbiology and Immunology Y1 - 1987/// VL - 8 SP - 176 EP - 218 AD - Howard, R. J.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861695. Publication Type: Journal Article. Language: English. Number of References: 101 ref. Subject Subsets: Protozoology N2 - Recent studies on antigenic diversity on infected erythrocytes (Plasmodium knowlesi variant or SICA antigen, P. falciparum, P. chabaudi), and merozoites (P. knowlesi merozoite surface antigen, antigenic diversity of the major surface glycoprotein on merozoites) are reviewed. Other aspects of phenotypic diversity, and genetic and phenotypic lability in Plasmodium are also briefly considered. KW - antigens KW - Human diseases KW - parasites KW - variation KW - Apicomplexa KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenicity KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861695&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanisms of immune evasion in schistosomiasis. AU - Pearce, E. J. AU - Sher, A. JO - Contributions to Microbiology and Immunology JF - Contributions to Microbiology and Immunology Y1 - 1987/// VL - 8 SP - 219 EP - 232 AD - Pearce, E. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861696. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Helminthology N2 - Mechanisms by which older schistosome larvae (>24 h) and adults evade the immune system are discussed with regard to low surface antigenicity (disguise, host molecule mimicry, surface antigen sequestration and shedding), the role of reduced surface antigenicity as a defence against immune attack, the nature of intrinsic mechanisms of immune evasion, other evasion mechanisms and the consequences of immune evasion in relation to vaccine development. KW - helminths KW - Human diseases KW - immune evasion KW - immunity KW - parasites KW - Digenea KW - man KW - Schistosoma KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosomatidae KW - Digenea KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861696&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of pathologic changes in mammalian hosts infected with Schistosoma mansoni, S. japonicum and S. haematobium. AU - Cheever, A. W. JO - Memórias do Instituto Oswaldo Cruz JF - Memórias do Instituto Oswaldo Cruz Y1 - 1987/// VL - 82 IS - Suppl. 4 SP - 39 EP - 45 SN - 0074-0276 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA. N1 - Accession Number: 19900868756. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 44 ref. Subject Subsets: Helminthology N2 - The differences and similarities of the hepatic, intestinal and cardiopulmonary lesions produced by S. mansoni, S. haematobium and S. japonicum in humans and animals are reviewed and discussed. KW - helminths KW - Human diseases KW - Laboratory animals KW - lesions KW - parasites KW - pathology KW - Schistosomiasis KW - Brazil KW - Digenea KW - man KW - rodents KW - Schistosoma haematobium KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - bilharzia KW - bilharziasis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900868756&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel. AU - Brindley, P. J. AU - Sher, A. JO - Memórias do Instituto Oswaldo Cruz JF - Memórias do Instituto Oswaldo Cruz Y1 - 1987/// VL - 82 IS - Suppl. 4 SP - 157 EP - 161 SN - 0074-0276 AD - Brindley, P. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19910868810. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 24 ref. Registry Number: 3105-97-3, 55268-74-1. Subject Subsets: Helminthology N2 - Recent observations on hycanthone (HC) and praziquantel (PZA) are reported. A laboratory model of drug resistance to hycanthone in Schistosoma mansoni is discussed and it is demonstrated that drug sensitive and resistant lines of the parasite can be differentiated on the basis of restriction fragment length polymorphisms using homologous ribosomal gene probes. Data are summarized demonstrating that effective chemotherapy of S. mansoni infection with praziquantel in mice requires the presence of host anti-parasite antibodies. These antibodies bind to praziquantel-treated worms and may be involved in antibody-dependent cellular cytotoxicity reactions which result in the clearance of worms from the blood vessels of the liver. KW - Anthelmintics KW - Antibodies KW - drug resistance KW - helminths KW - Human diseases KW - hycanthone KW - mode of action KW - parasites KW - praziquantel KW - resistance mechanisms KW - Schistosomiasis KW - Brazil KW - Digenea KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - bilharzia KW - bilharziasis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910868810&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Receptor-mediated clearance of Aspergillus galactomannan. AU - Bennett, J. E. AU - Friedman, M. M. AU - Dupont, B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1987/// VL - 155 IS - 5 SP - 1005 EP - 1010 SN - 0022-1899 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901207476. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The fate of radiolabelled A. fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 h the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 h. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, α-methylmannoside and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabelled galactomannan to be concentrated in Kupffer cells, which express the mannosyl receptor for glycoproteins. It is suggested that macrophage mannosyl receptors may constitute a general mechanism for clearing fungal mannans from the bloodstream. KW - antigens KW - galactomannans KW - immunology KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - antigenicity KW - fungus KW - Hyphomycetes KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207476&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Description, mechanisms and control of reactions to treatment in the human filariases. AU - Ottesen, E. A. A2 - Evered, D. A2 - Clark, S. T2 - Filariasis. Y1 - 1987/// CY - Chichester; UK PB - John Wiley and Sons Ltd. SN - 0471910937 AD - Ottesen, E. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864639. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 41 ref. Registry Number: 90-89-1, 1642-54-2. Subject Subsets: Helminthology N2 - The host reactions to the chemotherapy of the human filariases are discussed. The first section describes the reactions (the clinical manifestations and histopathology of the Mazzotti reaction in onchocerciasis, and the similar reactions associated with diethylcarbamazine (DEC) treatment in lymphatic filariasis, loiasis, streptocerciasis, and Mansonella perstans and M. ozzardi infections). The 2nd section explains the mechanisms underlying these adverse reactions (using data from studies in humans and animals), and the 3rd section advises on the control of the reactions (decreasing or spacing initial DEC doses, topical routes of administering DEC in onchocerciasis, the use of anti-inflammatory drugs, and the use of antifilarial drugs other than DEC). KW - Anthelmintics KW - diethylcarbamazine KW - DRUG THERAPY KW - Filariasis KW - filariids KW - helminths KW - Human diseases KW - parasites KW - Toxicity KW - man KW - Nematoda KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - chemotherapy KW - discussion KW - nematodes KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864639&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Iron status and cellular immune competence. AU - Good, M. F. AU - Powell, L. W. AU - Halliday, J. W. JO - Blood Reviews JF - Blood Reviews Y1 - 1988/// VL - 2 IS - 1 SP - 43 EP - 49 SN - 0268-960X AD - Good, M. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418827. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - From this review it is concluded that iron overload and Fe deficiency are associated with significant abnormalities of immune function. In diseases associated with Fe overload there is increased susceptibility to infection and neoplasia. The precise mechanisms are still not clear but Fe overload has been shown to impair antigen-specific immune responses and to reduce the number of functional helper precursor cells. Similarly, Fe in vitro in concentrations reported to be present in the serum of patients with Fe overload impairs the generation of cytotoxic T-cells, increases suppressor T-cell activity and reduces the proliferative capacity of helper T-cells. The predominant tumour seen in Fe overload is primary hepatocellular carcinoma, but other aetiological factors seem to be involved in addition to Fe overload, especially hepatic cirrhosis. Nevertheless, primary liver cancer occurs much more frequently in haemochromatosis than in other forms of cirrhosis. Fe deficiency is associated with an altered response to infection but the relation is complex. The cellular mechanisms involved have yet to be clearly defined, although impaired T and B cell function have been demonstrated. KW - immunity KW - Iron KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418827&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A method for determining the magnesium concentration of mononuclear blood cells. AU - Hosseini, J. AU - Elin, R. J. JO - Trace Elements in Medicine JF - Trace Elements in Medicine Y1 - 1988/// VL - 5 IS - 2 SP - 47 EP - 51 AD - Hosseini, J.: Clinical Pathology Department, Building 10, Room 2C-306, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419945. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7439-95-4. Subject Subsets: Human Nutrition N2 - Mononuclear blood cell (MBC) magnesium may provide a better index of intracellular Mg or total body Mg status than plasma or red blood cell (RBC) Mg. A method is described for the estimation of the Mg concentration of MBC, and results are reported with this method using blood from 20 normal persons. The method employs a Ficoll-Hypaque gradient for separation of cells, count and volume measurement with a particle analyser, and estimation of Mg by atomic absorption spectroscopy. The results (mean ± s.d.) show a MBC Mg concentration of 10.47 ± 2.01 mmol/litre and a MBC Mg content of 3.23 ± 0.67 fmol/cell. The results of Mg concentration and content were correlated significantly. There were no other significant correlations among plasma Mg concentration, RBC Mg concentration, MBC Mg concentration, MBC Mg content and age. Using Student's t-test, no differences were found between sex or race in any of the values measured. MBC Mg expressed as concentration is the preferred measurement as it is independent of the size of the cells in the population, and gives comparable units to other body tissues for Mg. KW - blood KW - estimation KW - Magnesium KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419945&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Deviations in brain development of F2 generational calorie undernutrition and scope of their prevention by rehabilitation: imbalances in the levels of noradrenaline, dopamine and serotonin in different brain regions. AU - Annamma, C. AU - Desiraju, T. JO - Biogenic Amines JF - Biogenic Amines Y1 - 1988/// VL - 5 IS - 5 SP - 323 EP - 337 SN - 0168-8561 AD - Annamma, C.: T. Desiraju, Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. N1 - Accession Number: 19901450761. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - The effects of chronic energy undernutrition on ontogenetic imbalances in norepinephrine (NE), dopamine (DA) and serotonin (5HT) were assessed in different regions of F2 generation rat brain, and also the extent of protection possible by postweaning rehabilitatory nutrition. Whole-brain estimations revealed that NE and 5HT concentrations, but not DA, were significantly increased in the undernourished. Analysis of regions revealed that the increase of NE was significant in the olfactory bulb, ventral brainstem, hippocampus, cingulate-medial frontal region and motor cortex, while no such increase occurred in the visual cortex. DA increases were significant in the olfactory bulb and the cingulate region, but not in the other areas. 5HT increases were significant in all those areas, but in visual cortex the change was opposite. Postweaning nutritional rehabilitation has prevented some of these changes only, and significant abnormalities continued to persist in adult rats (150 days old). The NE aberrations were significantly prevented in the cingulate only. The DA aberration was significantly prevented in both olfactory bulb and cingulate. The 5HT aberration recovered in cingulate and motor cortex, but not in other regions. KW - brain KW - Malnutrition KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic control of vaccine-induced immunity against a parasitic helminth, Schistosoma mansoni. AU - Sher, A. AU - James, S. JO - BioEssays JF - BioEssays Y1 - 1988/// VL - 9 IS - 5 SP - 163 EP - 166 SN - 0265-9247 AD - Sher, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900865534. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Helminthology N2 - Approaches to vaccination against S. mansoni in mice, the most commonly used experimental model for schistosomiasis, congenital immunodeficiencies influencing the resistance induced by an attenuated vaccine, genetic analysis of P-mouse vaccine defects, gene loci influencing vaccine-induced immunity, and genetic control of immunity induced by a non-living vaccine are discussed. KW - genetic control KW - helminths KW - Human diseases KW - immunization KW - Laboratory animals KW - parasites KW - Vaccines KW - Digenea KW - mice KW - Rodents KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - discussion KW - immune sensitization KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calcium and colon cancer: a review. AU - Sorenson, A. W. AU - Slattery, M. L. AU - Ford, M. H. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1988/// VL - 11 IS - 3 SP - 135 EP - 145 SN - 0163-5581 AD - Sorenson, A. W.: National Institutes of Health, National Institute on Aging, Geriatrics Branch, Bethesda, MD 20892, USA. N1 - Accession Number: 19911436889. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition N2 - Epidemiological data are reviewed to evaluate the role of dietary calcium as a protective factor in the aetiology of colon cancer; ecological and analytical epidemiological studies are examined. Biological evidence explaining mechanisms whereby Ca intake could alter risk of developing colon cancer is also presented. The data reviewed generally support the hypothesis that dietary Ca is linked to colon cancer in a protective manner. It may be one component in the aetiology of colon cancer which alters an individual's risk of developing the disease. KW - calcium KW - Carcinoma KW - colon KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911436889&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality among agricultural extension agents. AU - Alavanja, M. C. R. AU - Blair, A. AU - Merkle, S. AU - Teske, J. AU - Eaton, B. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1988/// VL - 14 IS - 2 SP - 167 EP - 176 SN - 0271-3586 AD - Alavanja, M. C. R.: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health and Human Services, Executive Plaza North, Room 543, Bethesda, MD 20892, USA. N1 - Accession Number: 19900501643. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology N2 - The death of agricultural extension agents employed by the Cooperative Extension Service (CES) of the US Department of Agriculture, who died between 1 January 1970 and 31 December 1979 (n = 1495 white males), was evaluated in proportionate-mortality and case-control studies. Proportionate-mortality analysis was used to identify cancers in this occupational group which could be compared with the US white male population as a whole. All cancers with a significantly elevated proportionate-mortality ratio were more thoroughly evaluated in the case-control study, where there is presumably less of a selection bias in the comparison. In the case-control study, cases of leukaemia were linearly correlated with duration of employment as an extension agent. Smaller, but non-significant, trends were seen for non-Hodgkin's lymphoma, multiple myeloma and brain cancer. The odds ratio for Hodgkin's disease and cancers of the colon, prostate and kidney did not vary with the number of years employed. The cancer distribution patterns resembled those seen among farmers, suggesting that agricultural factors may also play a role in the origin of cancerous tumours among extension agents. KW - agricultural entomology KW - Agriculture KW - Death KW - Disease surveys KW - effects KW - Epidemiology KW - extension agents KW - Farm workers KW - Health KW - Leukaemia KW - mortality KW - Neoplasms KW - Nontarget effects KW - Occupational hazards KW - pesticides KW - North America KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - blood cancer KW - cancers KW - death rate KW - disease surveillance KW - leucaemia KW - leukemia KW - United States of America KW - Occupational Health and Safety (VV900) KW - Pesticides and Drugs (General) (HH400) KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900501643&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemotaxonomic implications of the venom chemistry of some Monomorium "antarcticum" populations. AU - Jones, T. H. AU - Stahly, S. M. AU - Don, A. W. AU - Blum, M. S. JO - Journal of Chemical Ecology JF - Journal of Chemical Ecology Y1 - 1988/// VL - 14 IS - 12 SP - 2197 EP - 2212 SN - 0098-0331 AD - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19900597308. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A comparative analysis of the venom alkaloids produced by ants in the genus Monomorium collected from 28 locations on North Island and South Island, New Zealand, was undertaken. All of the ants produce trans-2,5-dialkylpyrrolidines along with 3,5-dialkylpyrrolizidines. The structures and sterochemistry of the novel alkaloids trans-2-butyl-5-(8-nonenyl)pyrrolidine, (5E,8Z)-3,5-di(5-hexenyl)pyrrolizidine and (5Z,8E)-3-methyl-5-(8-nonenyl)pyrrolizidine were established by unambiguous synthesis. The geographic distribution and the chemotaxonomic significance of the alkaloids produced by these ants are discussed. The M. antarcticum complex in New Zealand is thought to contain 4-7 species, based on this biochemical analysis. KW - Alkaloids KW - biochemistry KW - Chemotaxonomy KW - Sibling species KW - Taxonomy KW - venoms KW - New Zealand KW - Oceania KW - Formicidae KW - Hymenoptera KW - Monomorium KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Formicidae KW - Monomorium KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - biochemical taxonomy KW - Monomorium antarcticum KW - systematics KW - venom KW - Plant Composition (FF040) KW - Taxonomy and Evolution (ZZ380) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597308&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. AU - Khillan, J. S. AU - Deen, K. C. AU - Yu, S. AU - Sweet, R. W. AU - Rosenberg, M. AU - Westphal, H. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1988/// VL - 16 IS - 4 SP - 1423 EP - 1430 SN - 0305-1048 AD - Khillan, J. S.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19890168593. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology N2 - Transgenic mice were generated carrying either the long terminal repeat of human immunodeficiency virus fused to the bacterial chloramphenicol acetyltransferase reporter gene, or a control element of the mouse αA crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing the 2 transgenic strains, progeny were obtained which carried both transgenes. The bacterial reporter gene was specifically transactivated in the eyes of these animals. KW - Biotechnology KW - crystallins KW - experiments KW - Eyes KW - gene expression KW - Genes KW - Genetic engineering KW - germ line KW - HIV infections KW - Molecular biology KW - Transactivation KW - transgenics KW - tropisms KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic manipulation KW - human immunodeficiency virus infections KW - insertion KW - mouse KW - transcriptional activation KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890168593&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mung bean nuclease exhibits a generalized gene-excision activity upon purified Plasmodium falciparum genomic DNA. AU - Vernick, K. D. AU - Imberski, R. B. AU - McCutchan, T. F. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1988/// VL - 16 IS - 14 SP - 6883 EP - 6896 SN - 0305-1048 AD - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19890859864. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology N2 - A novel set of reaction conditions for mung bean nuclease was previously described in which Plasmodium genes were specifically excised as intact fragments from purified DNA. Under the new conditions mung bean nuclease cleaves precisely at sites outside of the coding region of every P. falciparum gene for which the extent of the protein coding region in genomic DNA is known, suggesting that this enzyme activity is probably a general one for P. falciparum genes. Introns were not specifically cleaved, although one gene contained a cleavage site within an intron. There was no direct relationship between dA.dT-richness and sites of cleavage under these conditions. Also contrary to the expectations of a model based on cleavage at denaturation bubbles, there was no general relationship between the concentration of the DNA denaturant, formamide, and the size of the resulting gene-containing fragments. Thus, the data strongly suggest the involvement of an altered DNA structure near gene boundaries in determining the recognition sites for this enzyme activity. KW - Human diseases KW - molecular genetics KW - parasites KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - genomic DNA KW - mung bean nuclease cleavage KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859864&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Receptors for gut hormones. AU - Gardner, J. AU - Jensen, R. JO - Italian Journal of Gastroenterology JF - Italian Journal of Gastroenterology Y1 - 1988/// VL - 20 IS - 5 SP - 281 EP - 286 SN - 0392-0623 AD - Gardner, J.: National Institutes of Health Building 10, Room 9C-103 Bethesda, MD 20892, USA. N1 - Accession Number: 19901416969. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition N2 - This lecture discusses the receptors within the gastrointestinal endocrine system for the gut hormones cholecystokinin, secretin and gastrin. KW - Gastrointestinal hormones KW - receptors KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gastric hormones KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901416969&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The genetics and expression of an esterase locus in Anopheles gambiae. AU - Vernick, K. D. AU - Collins, F. H. AU - Seeley, D. C. AU - Gwadz, R. W. AU - Miller, L. H. JO - Biochemical Genetics JF - Biochemical Genetics Y1 - 1988/// VL - 26 IS - 5/6 SP - 367 EP - 379 SN - 0006-2928 AD - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900598475. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The main polymorphic esterase isoenzymes in adults of the G3 laboratory strain of A. gambiae consists of 2-5 major bands of activity per individual. The bands are designated 5S, 5F, 13, 14 and 15. In genetic crosses, the genes which coded for the bands assorted as 3 codominant alleles, Est A, Est B and Est C, at a single autosomal locus. Homozygotes for the Est C allele were significantly underrepresented among backcross progeny. The developmental pattern of esterase expression was examined. Esterase gene expression in embryos was first detectable between 2 and 12 h after oviposition. The initiation or termination of expression of some of the bands corresponded to boundaries between developmental stages. Most of the esterase fractions were not specifically localized within the tissues tested, with the exception of a series of bands which were restricted largely to adult male testes. KW - Development KW - Enzymes KW - esterases KW - gene expression KW - genetics KW - Isoenzymes KW - molecular genetics KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - isozymes KW - mosquitoes KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Aquatic Biology and Ecology (MM300) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900598475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Influences of aging and dietary restriction on serum thymosinα1 levels in mice. AU - Weindruch, R. AU - Naylor, P. H. AU - Goldstein, A. L. AU - Walford, R. L. JO - Journal of Gerontology JF - Journal of Gerontology Y1 - 1988/// VL - 43 IS - 2 SP - B40 EP - B42 SN - 0022-1422 AD - Weindruch, R.: Biomedical Research and Clinical Medicine Program, National Institute on Aging, Bethesda, MD 20892, USA. N1 - Accession Number: 19901416981. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - Influences of age (3 weeks, 2, 7, 19 or 26 months old), long-term dietary restriction (DR) started at 3 weeks old and acute starvation on serum thymosinα1 (Tα1) values were measured by radioimmunoassay in female mice from a long-lived strain. Average Tα1 value was highest (about 60 ng/ml) at 3 weeks and fell sharply such that mice 2 months old fed on normal (N, about 80% of free intake) or restricted (R, about 50% of free intake) diets averaged about 20 ng/ml. Any age-related decreases after 2 months old were mild and significant only for R mice bled 2 to 4 h (but not 24 to 48 h) after feeding. Tα1 values were lower in group R than in group N mice in one experiment at 19 months old but not in another at 26 months old. The decline with age in serum Tα1 is mainly a very early life event for mice of this hybrid strain and seems uninfluenced by DR. Tα1 values are variably reduced by DR later in life. KW - age KW - blood KW - food intake KW - Thymus hormones KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901416981&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antigenic variation of Giardia lamblia in vivo. AU - Aggarwal, A. AU - Nash, T. E. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1988/// VL - 56 IS - 6 SP - 1420 EP - 1423 SN - 0019-9567 AD - Aggarwal, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862609. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology N2 - Gerbils were inoculated with defined G. lamblia clones and the surface antigens of the intestinal trophozoites were studied at different times during the infection. The proportion of MAb 6E7-reacting trophozoites from WB C1-6E7S-inoculated gerbils had decreased significantly by day 3 postinoculation, indicating the presence of a heterogeneous population. On day 7, the 170 000 MW antigen was no longer present and was replaced by a variety of antigens, including a major protein of 92 000 MW. With the exception of isolates from gerbils inoculated with WB A6-6E7S, the banding patterns of G. lamblia isolated from gerbils on day 7 or later were the same regardless of the clones used for inoculation. These studies show that G. lamblia changes its surface antigen(s) in vivo within 7 days following inoculation and appears to maintain the same set of surface antigens during the course of infection. KW - antigenic variation KW - Antigens KW - Human diseases KW - immunology KW - Laboratory animals KW - parasites KW - Giardia duodenalis KW - Meriones unguiculatus KW - protozoa KW - Rodents KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Meriones KW - Gerbillinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - antigenic polymorphism KW - antigenicity KW - Giardia lamblia KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862609&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aspartame intolerance. AU - Garriga, M. M. AU - Metcalfe, D. D. JO - Annals of Allergy JF - Annals of Allergy Y1 - 1988/// VL - 61 IS - 6,II SP - 63 EP - 69 SN - 0003-4738 AD - Garriga, M. M.: D.D. Metcalfe, Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 11C210, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419312. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 22839-47-0. Subject Subsets: Human Nutrition N2 - From a review of research on aspartame it is concluded that although concern has been expressed over its widespread use analysis of adverse reaction reports and available clinical data suggests that it is remarkably safe. Reports documenting allergic reactions are rare. KW - Aspartame KW - safety KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419312&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structure-function studies on Acanthamoeba myosins IA, IB and II. AU - Korn, E. D. AU - Atkinson, M. A. L. AU - Brzeska, H. AU - Hammer, J. A., III AU - Jung, G. AU - Lynch, T. J. JO - UCLA Symposia on Molecular and Cellular Biology, New Series JF - UCLA Symposia on Molecular and Cellular Biology, New Series Y1 - 1988/// VL - 77 SP - 69 EP - 82 AD - Korn, E. D.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861018. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Protozoology N2 - This paper was originally published in Journal of Cellular Biochemistry (1988) 36 (1), 37-50 and has been abstracted (see Protozoological Abstracts (1988) 12, No 2353). KW - biochemistry KW - Human diseases KW - myosins KW - parasites KW - proteins KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861018&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food choices and the cancer guidelines. AU - Patterson, B. H. AU - Block, G. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1988/// VL - 78 IS - 3 SP - 282 EP - 286 SN - 0090-0036 AD - Patterson, B. H.: Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417827. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - Diet of a representative sample of 11 658 non-institutionalized civilian adults 19 to 74 years old in the USA included in the second National Health and Nutrition Examination Survey of 1976-80 was studied by 24-h recall in relation to subsequent cancer guidelines of the US National Research Council and the American Cancer Society. Cruciferous vegetables, fruits and vegetables rich in vitamin A and high-fibre breads and cereals were consumed by only 18, 21 and 16% of the population sample, compared with 55% for red meat and 43% for bacon and luncheon meats. Numbers using fruit and vegetables increased with income. Diets of women, black persons and older age groups came closest to the guidelines. KW - Carcinogenesis KW - diets KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417827&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calories, fat and cholesterol: intake patterns in the US population by race, sex and age. AU - Block, G. AU - Rosenberger, W. F. AU - Patterson, B. H. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1988/// VL - 78 IS - 9 SP - 1150 EP - 1155 SN - 0090-0036 AD - Block, G.: Surveillance and Operations Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza No., Room 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19901450913. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition N2 - Nutrient intakes were investigated for black and white subjects using 24-h dietary recall data from the Second National Health and Nutrition Examination Survey (NHANES II, 1976-80). The study included a total of 10 322 white and 1336 black adults 19 to 74 years old. Intake of energy, total fat, saturated fat, dietary cholesterol, ratio of polyunsaturated fats to saturated fats (P:S) and percentage of energy derived from total and saturated fat were examined by sex and age. Black subjects had a lower intake of energy and fats than white persons and a consistently higher intake of dietary cholesterol. The P:S ratio was higher in women than in men, but all groupings by sex and age were substantially below recommended amounts. Percentage of energy from total and saturated fat was similar in most age and sex groupings. Possible explanations of the patterns to include activity level and metabolic differences are suggested. KW - age KW - ethnic groups KW - intake KW - Nutrients KW - sex differences KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450913&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors in oral and pharyngeal cancer. AU - McLaughlin, J. K. AU - Gridley, G. AU - Block, G. AU - Winn, D. M. AU - Preston-Martin, S. AU - Schoenberg, J. B. AU - Greenberg, R. S. AU - Stemhagen, A. AU - Austin, D. F. AU - Ershow, A. G. AU - Blot, W. J. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1988/// VL - 80 IS - 15 SP - 1237 EP - 1243 SN - 0027-8874 AD - McLaughlin, J. K.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Room 415, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418840. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - A population-based case-control study of oral and pharyngeal cancer in 4 areas of the USA provided information on a number of risk factors, including diet. Interviews were obtained from 871 oral cancer patients and 979 controls among white persons, frequency-matched for age and sex. Consumption frequency of 61 food items was assessed in the questionnaire; attention was given to foods that are sources of vitamins A and C and carotene. The major finding was an inverse relation between fruit intake and risk of oral and pharyngeal cancer; persons in the highest quartile of intake had about half the risk of those in the lowest quartile. Vitamin C, carotene or fibre in fruit did not seem to account completely for this relation as these nutrients in vegetables did not provide similar protection. This finding suggests the influence of other constituents in fruits, although it is possible that cooking vegetables may have a nutrient-diminishing effect. Dietary intake of other nutrients, such as the B vitamins, vitamin E, folate and iron, showed no consistent relation to risk of oral and pharyngeal cancer. Coffee or other hot beverage consumption did not increase risk; intake of nitrite-containing meats or cooking practices, such as smoking, pickling or charcoal grilling, also did not increase risk. All analyses were adjusted for the effects of tobacco and alcohol, strong risk factors for oral and pharyngeal cancer. Dietary findings among the few subjects who did not use tobacco or alcohol were similar to those for all subjects. KW - Carcinoma KW - diets KW - mouth KW - pharynx KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418840&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breast-feeding incidence and duration in black and white women. AU - Kurinij, N. AU - Shiono, P. H. AU - Rhoads, G. G. JO - Pediatrics JF - Pediatrics Y1 - 1988/// VL - 81 IS - 3 SP - 365 EP - 371 SN - 0031-4005 AD - Kurinij, N.: Epidemiology Branch, Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900441288. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science; Human Nutrition N2 - The influence of socio-demographic factors on the incidence and duration of breast-feeding was evaluated in 668 black and 511 white women delivering their first child in the metropolitan Washington, DC, USA, area. Breast-feeding rates were 84% among white and 49% among black women. Maternal educational level was strongly associated with breast-feeding, whereas the effect of ethnicity was moderate. Women with some college or some graduate school education had adjusted odds of breast-feeding that were 2.6 (95% confidence limit 1.9 to 3.7) and 5.2 (95% confidence limit 2.7 to 10.2) times higher than women with a high school education or less. In contrast, the adjusted odds of breast-feeding were 2.0 (95% confidence limit 1.4 to 3.1) times higher for white women compared with black women. The odds of breast-feeding increased among black women if they attended childbirth classes, were married or were older. Among black women, the frequency of breast-feeding decreased sharply by 1 month post partum. Breast-feeding duration for black vs. white women was 74 vs. 90% at 1 month, 44 vs. 72% at 4 months and 26 vs. 50% at 7 months post partum. The majority of black women (53%) used formula supplements in the hospital, which was the only factor significantly related to a shortened duration in this group (P<0.01). The high rate of formula supplementation among black women and its strong association with shortened duration of breast-feeding indicate a need for more advice and support, and less reliance on formula during the hospital stay. KW - Breast feeding KW - duration KW - education KW - ethnic groups KW - incidence KW - infants KW - District of Columbia KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Education, Extension, Information and Training (General) (CC000) KW - Milk and Dairy Produce (QQ010) KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900441288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The contribution of enrichment and fortification to nutrient intake of women. AU - Subar, A. F. AU - Bowering, J. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1988/// VL - 88 IS - 10 SP - 1237 EP - 1242, 1245 SN - 0002-8223 AD - Subar, A. F.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-4200, USA. N1 - Accession Number: 19911453553. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - A group of 162 women, 25 to 49 years old was recruited from 3 suburban supermarkets in central New York State, USA. The women completed 3-day food records, which were analysed for total nutrient intake and contribution of 8 nutrients from 3 sources: nutrients naturally present in food, enriched/fortified foods with a standard of identity (FF + SI), and fortified foods without standards of identity (FF - SI). Subjects were placed into study groups of high-, moderate- and low-fortifiers on the basis of frequency of intake of highly fortified foods (FF - SI). For all groups, mean intakes of riboflavin, niacin and vitamins A and C were greater than 100% of the recommended daily allowances (RDA) without nutrient addition. Mean thiamin intake met the RDA only when the nutrient addition from FF + SI was included. Mean intakes of iron, calcium and vitamin D were all below the RDA even when all sources of intake were included. No significant differences between study groups were found for total nutrient intake. With the exceptions of vitamin C, vitamin D and Ca, high- and moderate-fortifiers had significantly greater nutrient intake from fortification. Low-fortifiers had greater intake from naturally occurring vitamins A and C than had high-fortifiers. KW - diet studies KW - Women KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453553&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The National Cholesterol Education Program: implications for dietetic practitioners from the Adult Treatment Panel Recommendations. AU - Ernst, N. D. AU - Cleeman, J. AU - Mullis, R. AU - Sooter-Bochenek, J. AU - Horn, L. van JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1988/// VL - 88 IS - 11 SP - 1401 EP - 1408 SN - 0002-8223 AD - Ernst, N. D.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911453571. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition N2 - Background information on the organization and objectives of the USA National Cholesterol Education Programme are discussed, focusing on the recommendations of the Adult Treatment Panel, e.g., classification of risk for developing coronary heart disease based on total and low-density-lipoprotein cholesterol concentrations and recommendations for treatment of patients with high blood cholesterol. The emphasis of the discussion is on dietary treatment. The implications of the recommendations for the dietetic practitioner are discussed. These include an expanded leadership role to meet the education needs of health professionals and patients. KW - Nutrition education KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453571&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Erythrocyte lipids in alcohol dependence. AU - Sanjeev Jain AU - Shetty, K. T. AU - Rajat Ray AU - Janakiramaiah, N. JO - Indian Journal of Medical Research JF - Indian Journal of Medical Research Y1 - 1988/// VL - 88 IS - December SP - 530 EP - 535 AD - Sanjeev Jain: K. T. Shetty, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. N1 - Accession Number: 19911432693. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - Erythrocyte lipid content, particularly cholesterol (CHL) and phospholipids (PL), was studied in 30 alcoholics and 26 age-matched controls. Haematological and liver function tests in the alcoholics indicated the onset of complications associated with alcoholism. Although alcoholism did not affect plasma CHL and PL values it caused an increase in CHL in erythrocytes and decreases in PL in erythrocytes and in erythrocyte number. KW - Alcoholism KW - erythrocytes KW - lipids KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood red cells KW - lipins KW - red blood cells KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911432693&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Caffeinated beverages and decreased fertility. AU - Wilcox, A. AU - Weinberg, C. AU - Baird, D. JO - Lancet JF - Lancet Y1 - 1988/// VL - ii IS - 8626-8627 SP - 1453 EP - 1456 AD - Wilcox, A.: Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NG 27709, USA. N1 - Accession Number: 19921445362. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 58-08-2. Subject Subsets: Human Nutrition N2 - A total 104 healthy women who had been attempting to become pregnant for 3 months were interviewed about their use of caffeinated beverages, alcohol and cigarettes. In their subsequent cycles, women who consumed more than the equivalent of one cup of coffee per day were half as likely to become pregnant, per cycle, as women who drank less. A dose-response effect was present. KW - Caffeine KW - Fertility KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - T cells, T sites, and malaria immunity - further optimism for vaccine development. AU - Good, M. F. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1988/// VL - 140 IS - 6 SP - 1715 EP - 1716 SN - 0022-1767 AD - Good, M. F.: The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900865425. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology N2 - Recent work on the role of T lymphocytes in immunity to malaria, and T-cell epitopes in malaria antigens is discussed with reference to malaria vaccine development. KW - epitopes KW - Human diseases KW - immune response KW - parasites KW - T lymphocytes KW - vaccines KW - Apicomplexa KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenic determinants KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865425&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of antigens and antibodies specific for Pneumocystis carinii. AU - Kovacs, J. A. AU - Halpern, J. L. AU - Swan, J. C. AU - Moss, J. AU - Parrillo, J. E. AU - Masur, H. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1988/// VL - 140 IS - 6 SP - 2023 EP - 2031 SN - 0022-1767 AD - Kovacs, J. A.: Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861598. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology N2 - To increase understanding of P. carinii and its interaction with its hosts, antigens specific for rodent and human P. carinii were identified by the immunoblot method after PAGE of P. carinii extracts. The MWs of the major antigens of rat P. carinii were 45 000, 110 000, and a broad band of 49 000 to 64 000, and of human P. carinii were 22 000, 24 000, and a broad band of 35 000 to 45 000. Human and rat Pneumocystis were not antigenically identical. Specific antibodies against rat P. carinii antigen were found in 18 of 79 rats by the immunoblot method. Specific antibodies against human P. carinii antigen were found in 32 of 33 adult human sera, but in only 1 of 8 sera from infants and children. Specific antibodies were found in sera of 13 of the 14 adults with no history of P. carinii pneumonia, and all 19 patients with recently diagnosed P. carinii pneumonia, including 9 patients with P. carinii pneumonia associated with AIDS. The results of this study support previous suggestions that a large proportion of adults have been exposed to P. carinii and provide a basis for the further investigations of host-P. carinii interactions. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antigens KW - Human diseases KW - immune response KW - Immunocompromised hosts KW - Laboratory animals KW - Opportunistic infections KW - parasites KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - rats KW - Rodents KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - Muridae KW - rodents KW - AIDS KW - antigenicity KW - fungus KW - immunity reactions KW - immunogens KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861598&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii pneumonia: therapy and prophylaxis. AU - Kovacs, J. A. AU - Masur, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1988/// VL - 158 IS - 1 SP - 254 EP - 259 SN - 0022-1899 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910880511. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Protozoology N2 - The current status of drugs available for therapy and prevention of P. carinii pneumonia in AIDS patients is assessed. The drugs considered include trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine and sulfadiazine in combination, dapsone, trimetrexate, difluoromethylornithine, clindamycin-primaquine and zidovudine (for prophylaxis). Treatment regimens, mode of administration, efficacies and toxicity are discussed KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiinfective agents KW - antiprotozoal agents KW - clinical aspects KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - Prophylaxis KW - reviews KW - Treatment KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - antimicrobials KW - chemotherapy KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910880511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enhanced diagnostic specificity in human filariasis by IgG4 antibody assessment. AU - Lal, R. B. AU - Ottesen, E. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1988/// VL - 158 IS - 5 SP - 1034 EP - 1037 SN - 0022-1899 AD - Lal, R. B.: E.A. Ottesen, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900865828. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases N2 - By configuring an enzyme immunoassay (ELISA) to assess antibodies of the IgG4 subclass only (because patients with filariasis usually generate a vigorous IgG4 antibody response to the infection, as well as because humans do not usually mount an IgG4 response to phosphocholine epitopes, a common cross-reactive determinant) serological false-positive results were eliminated in 32 of 34 cross-reactive sera from patients with non-filarial parasitic infections. Specificity was thus greatly enhanced with minimal loss of sensitivity. Because preadsorption of these cross-reactive sera to remove antibodies to PC eliminated only ~50% of the original cross-reactivity, it is suggested that other shared epitopes (perhaps similar to phosphocholine) are also likely to be restricted by IgG subclass. KW - antibodies KW - ELISA KW - Filariasis KW - Filariids KW - helminths KW - Human diseases KW - IgG KW - immunodiagnosis KW - Immunoglobulins KW - parasites KW - man KW - Nematoda KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - enzyme linked immunosorbent assay KW - gamma-globulins KW - IgG4 KW - immune globulins KW - nematodes KW - parasitic worms KW - serological diagnosis KW - specificity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865828&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular basis for mutation in a surface protein expressed by malaria parasites. AU - Hudson, D. E. AU - Wellems, T. E. AU - Miller, L. H. JO - Journal of Molecular Biology JF - Journal of Molecular Biology Y1 - 1988/// VL - 203 IS - 3 SP - 707 EP - 714 SN - 0022-2836 AD - Hudson, D. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869175. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - Plasmodium knowlesi parasites isolated from a rhesus monkey vaccinated with a 143 000/140 000 MW merozoite surface protein no longer expressed this protein. To study the molecular basis for the mutations, a λgt11 cDNA expression library constructed from the original parasite clone was screened with rabbit antiserum specific for the 143 000/140 000 MW protein. Two cDNA clones that mapped to the 5′ and 3′ ends of the gene hybridized to 2 chromosomes of 3.6×106 kb and 1.8×106 kb. The gene on the 3.6×106 base chromosome was identified as the gene expressing the 143 000/140 000 MW protein. Since the 2 cDNA clones also hybridized at high stringency with the 1.8×106 base chromosome, it appeared that the 143 000/140 000 MW gene was involved in an ancestral duplication and interchromosomal transposition. Mutant parasites were analysed using the cDNA clones and a 7000 base fragment of genomic DNA that contained the 143 000/140 000 MW gene. In one type of mutation, the 143 000/140 000 MW protein was replaced by a 76 000/72 000 MW protein. The identical restriction sites and the identical size of the mRNA indicated that a point mutation resulted in premature interruption of translation. Sequence analysis revealed an AT substitution for a C in the middle of the coding region of the gene that created a frameshift and a stop codon. In a 2nd type of mutation, no protein was expressed; a 4000 base deletion encompassed the transcriptional unit of the gene. The rapid mutation under vaccine pressure of an otherwise stable parasite protein emphasizes the need to identify vaccine candidates in which mutations would be lethal. KW - Biotechnology KW - DNA libraries KW - genes KW - Merozoites KW - mutations KW - parasites KW - surface proteins KW - Vaccines KW - Apicomplexa KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - membrane proteins KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869175&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunogenicity and epitope mapping of foreign sequences via genetically engineered filamentous phage. AU - Cruz, V. F. de la AU - Lal, A. A. AU - McCutchan, T. F. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1988/// VL - 263 IS - 9 SP - 4318 EP - 4322 SN - 0021-9258 AD - Cruz, V. F. de la: Malaria Division, Laboratory for Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19890165678. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Animal Breeding; Protozoology N2 - Repeat regions of the circumsporozoite protein gene of Plasmodium falciparum were cloned into the pIII gene of a filamentous phage, which displayed the recombinant proteins on its surface. Injection of recombinant phages produced an antibody response in C57BL/10 mice, but not in BALB/c mice. The antibody response appeared to be controlled by Ir genes. KW - antigens KW - Disease models KW - Human diseases KW - immune response KW - immunization KW - Immunogenetics KW - Laboratory animals KW - major histocompatibility complex KW - molecular genetics KW - parasites KW - Vaccines KW - Apicomplexa KW - mice KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenicity KW - biochemical genetics KW - histocompatibility complex KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - recombinant circumsporozoite protein gene KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890165678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transient impaired glucose tolerance in Pima Indians: is it important? AU - Saad, M. F. AU - Knowler, W. C. AU - Pettitt, D. J. AU - Nelson, R. G. AU - Bennett, P. H. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1988/// VL - 297 IS - 6661 SP - 1438 EP - 1441 SN - 0959-8138 AD - Saad, M. F.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA. N1 - Accession Number: 19901418751. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - As part of a continuing epidemiological study of noninsulin-dependent diabetes among Pima Indians in Arizona, USA, 154 subjects who had had a transient impairment of glucose tolerance were followed-up for 1.2 to 16.9, median 5.8 years after their glucose tolerance had returned to normal. Of these, 49 subsequently developed diabetes, 26 subsequently developed impaired glucose tolerance and 79 had normal glucose tolerance at the last examination. The cumulative incidence of diabetes was 16 and 48% at 5 and 10 years of follow-up, respectively, compared with 3 and 8% for a control group of 1245 members of the same population. After adjustment for age, sex, body mass index and plasma glucose concentration 2 h after glucose loading the incidence of diabetes among the subjects who had had transient impaired glucose tolerance was 3.0 times that among the controls (95% confidence interval 2.1 to 4.3). Proportional hazards function analysis indicated that obesity was the most important predictor of subsequent development of diabetes. The results suggest that transient impairment of glucose tolerance indicates, at least in some subjects a predisposition to diabetes and should not be considered clinically unimportant. KW - ethnic groups KW - Glucose tolerance KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood sugar tolerance KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418751&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies. AU - Kovacs, J. A. AU - Ng, V. L. AU - Masur, H. AU - Leoung, G. AU - Hadley, W. K. AU - Evans, G. AU - Lane, C. AU - Ognibene, F. P. AU - Shelhamer, J. AU - Parrillo, J. E. AU - Gill, V. J. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1988/// VL - 318 IS - 10 SP - 589 EP - 593 SN - 0028-4793 AD - Kovacs, J. A.: Bld. 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862799. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health; Protozoology N2 - Two prospective studies were carried out to assess whether an indirect immunofluorescent stain using MAbs was more sensitive than Giemsa or toluidine blue O staining for detecting P. carinii in sputum samples. Of 63 patients at one institution from whom sputum specimens were obtained, 49 were ultimately given a diagnosis of P. carinii pneumonia, 46 of them by staining of sputum. The sensitivity of the 3 stains in detecting P. carinii was 45 of 49 (92%) for immunofluorescence, 37 of 49 (76%) for Diff-Quik (a Giemsa-type stain), and 39 of 49 (80%) for toluidine blue O. There were no false positive immunofluorescent stains. In a similar study of a series of 225 patients at another institution, a diagnosis of P. carinii pneumonia was made in 23 of 25 patients by staining of induced sputum. Examination of induced sputum is considered a rapid, sensitive and inexpensive method for the diagnosis of P. carinii pneumonia; indirect immunofluorescence was a practical and highly sensitive staining technique.<new para>ADDITIONAL ABSTRACT:<new para>The authors evaluated the examination of induced sputum for Pneumocystis carinii using 3 staining methods and compared it with bronchoalveolar lavage. Of 63 patients, 49 were diagnosed as having P. carinii pneumonia. 46 were positive on stained sputum that was obtained after the patient inhaled a nebulized mist of 3% saline for 5-15 minutes which induced coughing. The stains compared were toluidine blue O, Giemsa and immunofluorescence with monoclonal antibodies that react with P. carinii. The sensitivity of the stains were 92% for immunofluorescence, 80% for toluidine blue O and 76% for Giemsa. They conclude that examination of induced sputum is an acceptable alternative method for the diagnosis of P. carinii to bronchoalveolar lavage and that indirect immunofluorescence is the staining method of choice.G.W. Csonka<new para>ADDITIONAL ABSTRACT:<new para>The authors evaluated the examination of induced sputum for Pneumocystis carinii using 3 staining methods and compared it with bronchoalveolar lavage. Of 63 patients, 49 were diagnosed as having P. carinii pneumonia. 46 were positive on stained sputum that was obtained after the patient inhaled a nebulized mist of 3% saline for 5-15 minutes which induced coughing. The stains compared were toluidine blue O, Giemsa and immunofluorescence with monoclonal antibodies that react with P. carinii. The sensitivity of the stains were 92% for immunofluorescence, 80% for toluidine blue O and 76% for Giemsa. They conclude that examination of induced sputum is an acceptable alternative method for the diagnosis of P. carinii to bronchoalveolar lavage and that indirect immunofluorescence is the staining method of choice.G.W. Csonka KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - clinical aspects KW - detection KW - Diagnosis KW - HIV infections KW - Human diseases KW - immunodiagnosis KW - Monoclonal antibodies KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - sputum KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - clinical picture KW - fungus KW - human immunodeficiency virus infections KW - indirect immunofluorescent stain KW - induced sputum KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862799&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. AU - Vogel, J. AU - Hinrichs, S. H. AU - Reynolds, R. K. AU - Luciw, P. A. AU - Jay, G. JO - Nature (London) JF - Nature (London) Y1 - 1988/// VL - 335 IS - 6191 SP - 606 EP - 611 SN - 0028-0836 AD - Vogel, J.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19890173661. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology N2 - When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region was introduced into the germ line of mice, skin lesions were induced that resemble Kaposi's sarcoma. KW - Biotechnology KW - genes KW - Genetic engineering KW - germ line KW - human immunodeficiency viruses KW - neoplasms KW - Sarcoma KW - transgenics KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - genetic manipulation KW - HUMAN IMMUNODEFICIENCY VIRUS KW - insertion KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890173661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Human nutrition. AU - Burton, B. T. AU - Foster, W. R. T2 - Human nutrition. Y1 - 1988/// IS - Ed. 4 CY - New York; USA PB - McGraw-Hill Book Company AD - Burton, B. T.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19901418562. Publication Type: Book. Language: English. Subject Subsets: Human Nutrition N2 - This is the fourth edition of the book formerly titled 'The Heinz Handbook of Nutrition', and includes sections covering utilization of foods, the food elements, nutrition in health and disease, and the role of nutrition in modern life. There are major additions in the areas of disease prevention, cancer, cardiovascular diseases, calcium, osteoporosis, obesity, anorexia nervosa and bulimia, alcoholism, total parenteral nutrition, and food allergy and toxicology. There are no references but 2 appendices cover the composition and nutritive value of foods (including food composition tables) and there is a subject index. KW - nutrition KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418562&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Long-range restriction studies of Plasmodium falciparum chromosomes. AU - Wellems, T. E. A2 - Turner, M. J. A2 - Arnot, D. T2 - Molecular genetics of parasitic protozoa. JO - Molecular genetics of parasitic protozoa. JF - Molecular genetics of parasitic protozoa. Y1 - 1988/// SP - 30 EP - 32 CY - Cold Spring Harbor, New York; USA PB - Cold Spring Harbor Laboratory SN - 0879693134 AD - Wellems, T. E.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874687. Publication Type: Conference paper. Language: English. Number of References: 9 ref. Subject Subsets: Protozoology KW - Chromosomes KW - molecular genetics KW - parasites KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - Human diseses KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874687&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Ecological and epidemiological considerations of Rocky Mountain spotted fever and scrub typhus. AU - Burgdorfer, W. A2 - Walker, D.H. T2 - Biology of rickettsial diseases. Volume I. JO - Biology of rickettsial diseases. Volume I. JF - Biology of rickettsial diseases. Volume I. Y1 - 1988/// SP - 33 EP - 50 CY - Boca Raton, Florida; USA PB - CRC Press, Inc. SN - 0849343828 AD - Burgdorfer, W.: National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA. N1 - Accession Number: 19900599139. Publication Type: Miscellaneous. Language: English. Number of References: 116 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The ecology and epidemiology of the zoonotic diseases caused by Rickettsia rickettsii and R. tsutsugamushi are discussed, with emphasis on tick and trombiculid vectors and animal hosts. KW - disease transmission KW - disease vectors KW - epidemiology KW - Human diseases KW - reviews KW - Tickborne diseases KW - transmission KW - Vectors KW - Zoonoses KW - Japan KW - USA KW - Acari KW - Arachnida KW - Ixodidae KW - Orientia tsutsugamushi KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Trombiculidae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Metastigmata KW - Acari KW - Orientia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Prostigmata KW - mites KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - North America KW - America KW - bacterium KW - Rickettsia tsutsugamushi KW - United States of America KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900599139&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antigenic variation in Giardia lamblia. AU - Nash, T. E. A2 - Turner, M.J. A2 - Arnot, D. T2 - Molecular genetics of parasitic protozoa. JO - Molecular genetics of parasitic protozoa. JF - Molecular genetics of parasitic protozoa. Y1 - 1988/// SP - 164 EP - 166 CY - Cold Spring Harbor, New York; USA PB - Cold Spring Harbor Laboratory SN - 0879693134 AD - Nash, T. E.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874710. Publication Type: Conference paper. Language: English. Number of References: 2 ref. Subject Subsets: Protozoology KW - antigenic variation KW - antigens KW - molecular genetics KW - parasites KW - Giardia duodenalis KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - biochemical genetics KW - Giardia lamblia KW - immunogens KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Carcinoma of the urinary bladder associated with schistosomiasis in Egypt: the possible causal relationship. AU - Tawfik, H. N. A2 - Miller, R. W. A2 - Watanabe, S. A2 - Fraumeni, J. F., Jr. A2 - Sugimura, T. A2 - Takayama, S. A2 - Sugano, H. T2 - Unusual occurrences as clues to cancer etiology. JO - Unusual occurrences as clues to cancer etiology. JF - Unusual occurrences as clues to cancer etiology. Y1 - 1988/// SP - 197 EP - 209 CY - Tokyo, Japan; Scientific Societies Press: London, UK; Japan PB - Taylor & Francis Ltd SN - 4762215562\0850664594 AD - Tawfik, H. N.: Department of Pathology, National Cancer Institute, Cairo University, Egypt. N1 - Accession Number: 19900863036. Publication Type: Conference paper. Language: English. Number of References: 57 ref. Subject Subsets: Helminthology N2 - The epidemiology of Schistosoma haematobium infection in Africa and Egypt in particular, and the factors that suggest a causal relationship between schistosomiasis and bladder cancer are outlined. The results of a study carried out in Egypt between 1982 and 1986, on the relationship between the intensity of schistosome egg deposition and various clinicopathological features of 264 cases of carcinoma of the bladder are presented. There was no significant correlation between age, sex, the involved trigone of the bladder, or type of carcinoma and the intensity of egg deposition. Early detection of schistosomal bladder cancer, the immunopathology of Schistosoma-associated bladder cancer, the possible role of schistosomiasis as a vesical carcinogen and factors against this theory are discussed. KW - Aetiology KW - bladder KW - carcinoma KW - helminths KW - Human diseases KW - neoplasms KW - parasites KW - Pathology KW - Africa KW - Egypt KW - Digenea KW - man KW - Schistosoma haematobium KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - cancers KW - causal agents KW - etiology KW - Misr KW - parasitic worms KW - Strigeida KW - urinary bladder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863036&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immunological consequences of polymorphism in circumsporozoite proteins. AU - Cruz, V. F. de la AU - Maloy, W. L. AU - Miller, L. H. AU - Lal, A. A. AU - Good, M. F. AU - McCutchan, T. F. A2 - Lasky, L. T2 - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA). JO - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA). JF - Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA). Y1 - 1988/// SP - 615 EP - 624 CY - New York; USA PB - Alan R. Liss, Inc. SN - 0845126830 AD - Cruz, V. F. de la: Malaria Division, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869088. Publication Type: Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - The discovery of polymorphism in T cell determinants of the circumsporozoite protein of Plasmodium falciparum may have a profound effect on the development of a sporozoite derived anti-malaria vaccine. The effects of polymorphism on T cell activity were tested in mice and a general lack of cross-reactivity was found. Polymorphism in T cell determinants may thus indicate that infection with sporozoites will not necessarily boost immune (antibody and/or cytotoxic) responses stimulated by prior infections or by a subunit vaccine. KW - circumsporozoite protein KW - Human diseases KW - immune response KW - Laboratory animals KW - parasites KW - polymorphism KW - T lymphocytes KW - Vaccines KW - Apicomplexa KW - mice KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - immunity reactions KW - immunological reactions KW - T cells KW - technological advances in vaccine development KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869088&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Conserved sequences of the HSP gene family in Giardia lamblia. AU - Aggarwal, A. AU - Romans, P. AU - Cruz, V. F. de la AU - Nash, T. E. A2 - Wallis, P. M. A2 - Hammond, B. R. T2 - Advances in Giardia research. Y1 - 1988/// CY - Alberta; Canada PB - University of Calgary Press SN - 0919813860 AD - Aggarwal, A.: NIAD, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879381. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology N2 - Transformation of G. lamblia [G. duodenalis] from trophic form to the cystic form is thought to be induced by a heat shock response. A factor was found in nuclear extract of Giardia trophozoites bound to heat shock element of Drosophila hsp 70. The sequence analysis of the 5′ flanking area showed a TATAA box at position -28 to -33 upstream to the initiation site and consensus promoter region at -56 to -69. The level of this factor was significantly increased after heat shock. KW - Biotechnology KW - genes KW - heat shock proteins KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - Giardia KW - GIARDIA DUODENALIS KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Giardia KW - biochemical genetics KW - DNA sequences KW - Hsp 70 KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879381&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Biological differences in Giardia lamblia. AU - Nash, T. E. AU - Aggarwal, A. A2 - Wallis, P. M. A2 - Hammond, B. R. T2 - Advances in Giardia research. Y1 - 1988/// CY - Alberta; Canada PB - University of Calgary Press SN - 0919813860 AD - Nash, T. E.: National Institutes of Health, NIAIB, LPD, Building 5, Rm 118 Bethesda, MD 20205, USA. N1 - Accession Number: 19920879359. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology N2 - Six-week-old Mongolian gerbils were infected with 2 unique human isolates of Giardia, GS/E and WB. All WB inoculated gerbils became infected and were able to self-cure by day 28 pi. In contrast, GS/E infected gerbils tended to remain infected. After treatment, previously WB infected gerbils resisted infection after re-challenge with WB and GS/E, while GS/E infected gerbils partially resisted re-challenge with GS/E. All were infected with WB. Resistance to infection correlated with the development of cytotoxic antibodies which reacted with the surface of the Giardia. Experimental infections in humans confirmed that Giardia isolates differed biologically. In the first study, 5 volunteers were enterally inoculated with 50 000 trophozoites of isolates GS/M or Isr, followed serially and treated on day 15 post inoculation. In the 2nd study, 2 of the previously inoculated, infected and treated volunteers were re-challenged along with 5 new volunteers as controls. All 10 of the GS/M inoculated volunteers became infected compared to none of the 5 inoculated with Isr. Both re-challenged individuals became infected although one only transiently shed cysts. Of the 10 infected, 5 became ill, 4 with diarrhoea and typical symptoms of giardiasis. Humoral immune responses to Giardia occurred in all infected volunteers. It is concluded that these experiments give credence to the idea that Giardia are not only biochemically different, but also differ in their biological behaviour. KW - Experimental infections KW - Giardiasis KW - Human diseases KW - Immunology KW - infectivity KW - Laboratory animals KW - parasites KW - strains KW - Giardia KW - GIARDIA DUODENALIS KW - Hexamitidae KW - man KW - Meriones unguiculatus KW - Muridae KW - protozoa KW - Rodents KW - Sarcomastigophora KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Giardia KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Meriones KW - Gerbillinae KW - Muridae KW - rodents KW - Biological differences KW - giardiosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Malarial proteins at the membrane of Plasmodium falciparum-infected erythrocytes and their involvement in cytoadherence to endothelial cells. AU - Howard, R. J. A2 - Perlmann, P. A2 - Wigzell, H. T2 - Malaria Immunology. Y1 - 1988/// CY - Basel; Switzerland PB - S. Karger AG SN - 3805546726 AD - Howard, R. J.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861845. Publication Type: Book chapter. Language: English. Number of References: 118 ref. Subject Subsets: Protozoology N2 - This review covers cytoadherence and knobs, receptors for infected erythrocytes on endothelial cells, properties of the cytoadherent moiety on infected cells, malarial proteins at the infected erythrocyte membrane, malarial transferrin receptor, Pf 11.1, other P. falciparum proteins and changes at the erythrocyte membrane, experiments to define the cytoadherent moiety, and clinical applications. KW - cytoadherence KW - host parasite relationships KW - Human diseases KW - immunology KW - parasites KW - Apicomplexa KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - cell adhesion KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861845&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antigenic diversity in Plasmodium falciparum. AU - McCutchan, T. F. AU - Cruz, V. F. de la AU - Good, M. F. AU - Wellems, T. E. A2 - Perlmann, P. A2 - Wigzell, H. T2 - Malaria Immunology. Y1 - 1988/// CY - Basel; Switzerland PB - S. Karger AG SN - 3805546726 AD - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861847. Publication Type: Book chapter. Language: English. Number of References: 56 ref. Subject Subsets: Protozoology N2 - This review focuses on the possible effects of both T and B epitope variations on developing immunity to P. falciparum, and the occurrence of antigenic variation in Plasmodium. The circumsporozoite protein, the S antigen and histidine-rich proteins are discussed. KW - antigens KW - Human diseases KW - immunology KW - parasites KW - Apicomplexa KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - antigenic diversity KW - antigenicity KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861847&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Genetically determined human resistance factors. AU - Miller, L. H. A2 - Wernsdorfer, W.H. A2 - McGregor, I. T2 - Malaria: principles and practice of malariology. Volume 1. Y1 - 1988/// CY - Edinburgh; UK PB - Churchill Livingstone SN - 0443024170 AD - Miller, L. H.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19900861481. Publication Type: Book chapter. Language: English. Number of References: 102 ref. Subject Subsets: Protozoology N2 - Factors influencing sporozoite infectivity and exoerythrocytic development, erythrocytic factors influencing the asexual erythrocytic parasite, the genetics of immune responsiveness and the genetic control of resistance to Plasmodium berghei are discussed. KW - Human diseases KW - malaria KW - parasites KW - resistance KW - Apicomplexa KW - man KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - host genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861481&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Advances in the biology and immunology of Pneumocystis carinii. AU - Kovacs, J. A. AU - Masur, H. A2 - Leech, J.H. A2 - Sande, M.A. A2 - Root, R.K. T2 - Parasitic infections. Y1 - 1988/// CY - New York; USA PB - Churchill Livingstone SN - 0443085617 AD - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910871891. Publication Type: Book chapter. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology N2 - Advances in the biology and immunology of P. carinii are discussed under several headings including: morphology, histopathology, and life cycle; biochemical studies; immunofluorescence and ELISA studies; immunoblot results; application of monoclonal antibodies. The studies performed and results in relation to AIDS patients are discussed. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Antibodies KW - ELISA KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - immunology KW - Opportunistic infections KW - parasites KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - enzyme linked immunosorbent assay KW - fungus KW - general account KW - human immunodeficiency virus KW - parasitic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871891&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Biologic differences among isolates of Giardia lamblia. AU - Nash, T. E. A2 - Leech, J.H. A2 - Sande, M.A. A2 - Root, R.K. T2 - Parasitic infections. Y1 - 1988/// CY - New York; USA PB - Churchill Livingstone SN - 0443085617 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910871888. Publication Type: Book chapter. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - Biological differences among isolates of G. lamblia are discussed with reference to studies on endonuclease restriction analysis of DNA, surface antigens, and evaluation of biological differences. Evidence gained through these studies is presented. KW - Biotechnology KW - Human diseases KW - Molecular genetics KW - parasites KW - strain differences KW - Trophozoites KW - Giardia duodenalis KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - Giardia lamblia KW - parasitic infections KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871888&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Recent advances in the diagnosis and management of leishmaniasis and American trypanosomiasis. AU - Neva, F. A. A2 - Leech, J.H. A2 - Sande, M.A. A2 - Root, R.K. T2 - Parasitic infections. Y1 - 1988/// CY - New York; USA PB - Churchill Livingstone SN - 0443085617 AD - Neva, F. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910871894. Publication Type: Book chapter. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology N2 - This chapter gives an insight into recent advances in the diagnosis and management of leishmaniasis and American trypanosomiasis. The diagnosis of Leishmania is discussed under the headings: specimen collection in cutaneous and mucocutaneous leishmaniasis; leishmanial culture for cutaneous and mucocutaneous disease; new technology for detection and speciation of Leishmania; serology in diagnosis; special considerations in diagnosis of kala-azar; new use of old drugs in treatment; local treatment of cutaneous leishmaniasis. Trypanosoma cruzi infection is discussed under the headings: serodiagnosis; is chronic Chagas' disease caused by certain varieties of T. cruzi?; antigen detection as an aid to diagnosis; chemotherapy of Chagas' disease. KW - Antiprotozoal agents KW - Chagas' disease KW - Cutaneous leishmaniasis KW - diagnosis KW - drug therapy KW - Human diseases KW - Mucocutaneous leishmaniasis KW - parasites KW - reviews KW - Trypanocides KW - Visceral leishmaniasis KW - Leishmania KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Trypanosoma KW - chemotherapy KW - espundia KW - parasitic infections KW - trypanocidal drugs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871894&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The statistical analysis of a carcinogen mixture experiment. III. Carcinogens with different target systems, aflatoxin B1, N-butyl-N-(4-hydroxybutyl)nitrosamine, lead acetate, and thiouracil. AU - Fears, T. R. AU - Elashoff, R. M. AU - Schneiderman, M. A. JO - Toxicology and Industrial Health JF - Toxicology and Industrial Health Y1 - 1989/// VL - 5 IS - 1 SP - 1 EP - 23 SN - 0748-2337 AD - Fears, T. R.: Biostatistics Branch, National Cancer Institute, Washington, DC, USA. N1 - Accession Number: 19901205748. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Factorial experiments designed to determine whether 2 carcinogens that lead to cancers in different organ systems act synergistically to produce cancers in Fisher 344 rats are described. Four carcinogens, aflatoxin B1, N-butyl-N-(4-hydroxybutyl)nitrosamine, lead acetate and thiouracil were studied in paired combinations. Each of the 6 possible pairs were studied by means of a 4×4 factorial experiment, each agent being fed at zero and at 3 non-zero doses. Methods of analysis designed explicitly for this study were derived to study interaction. These methods were supplemented by standard statistical methods appropriate for single agent studies. Neither synergism nor antagonism was demonstrated in these combined exposure studies. Findings for male and female animals were consistent. KW - Aflatoxins KW - carcinogenesis KW - Mycotoxins KW - poisoning KW - toxicity KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fungal toxins KW - toxicosis KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205748&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lysosomal membrane transport in cellular nutrition. AU - Gahl, W. A. JO - Annual Review of Nutrition JF - Annual Review of Nutrition Y1 - 1989/// VL - 9 SP - 39 EP - 61 SN - 0199-9885 AD - Gahl, W. A.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419333. Publication Type: Journal Article. Language: English. Number of References: 122 ref. Subject Subsets: Human Nutrition N2 - A host of cellular nutrients are synthesized within the cell itself or enter directly via transport across the plasma membrane, but a significant portion of the small molecules necessary for a cell's growth and metabolism require passage through the lysosome or a similar acidic vesicular compartment. These nutrients arrive in the lysosome by hydrolysis of macromolecules or by receptor-mediated endocytosis. They leave by carrier-mediated transport or, it is speculated, by intermembrane transfer in the case of lipophilic substances. In either case, a vesicular membrane provides the key to communication between the lysosome and the cytosol, and that membrane now requires intensive study. The success of future pursuits in this area will be aided by an increased recognition of the importance of the lysosome-to-cytosol step in cellular metabolism. For example, investigators might ask how iron gets out of endosomes, or how thyroxine gets out of lysosomes. In addition, naturally occurring mutations, or inborn errors of metabolism, provide invaluable opportunities to delineate a normal pathway, using the mutant for comparison. Physicians and scientists alike can advance our knowledge of lysosomal membrane transport by increasing their collective index of suspicion that unknown lysosomal storage disorders might represent transport defects, rather than strictly enzymic defects. KW - Cells KW - lysosomes KW - nutrition KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419333&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selenium metabolism and selenium-dependent enzymes in microorganisms. AU - Axley, M. J. AU - Stadtman, T. C. JO - Annual Review of Nutrition JF - Annual Review of Nutrition Y1 - 1989/// VL - 9 SP - 127 EP - 137 SN - 0199-9885 AD - Axley, M. J.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419342. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition KW - metabolism KW - Selenium KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419342&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The influence of zinc supplementation on glucose homeostasis in NIDDM. AU - Raz, I. AU - Karsai, D. AU - Katz, M. JO - Diabetes Research JF - Diabetes Research Y1 - 1989/// VL - 11 IS - 2 SP - 73 EP - 79 SN - 0265-5985 AD - Raz, I.: I. Raz, National Institutes of Health, 4212 North 16th Street, Room 5441-A, Phoenix, AZ 85016, USA. N1 - Accession Number: 19921444963. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 50-99-7, 7440-66-6. Subject Subsets: Human Nutrition N2 - Serum zinc and 24-h urine in 97 patients with non-insulin-dependent diabetes mellitus (NIDDM) were compared with values in 62 age- and sex-matched healthy persons. Urine Zn was significantly increased in the diabetic group. For 7 to 8 weeks 13 diabetics with high urine Zn and low serum Zn were given zinc sulphate 220 mg, 3 times daily. Glucose disposal decreased significantly whereas values for fasting glucose increased significantly from 177 ± 10 to 207 ± 15 mg/100 ml and those for fructosamine from 2.7 ±0.2 to 3.2 ± 0.28%. T-lymphocyte response to phytohaemagglutinin increased significantly. It is concluded that Zn supplements may aggravate the glucose intolerance of NIDDM patients with high serum Zn and low urine Zn. Zn supplements are not recommended for such patients until more accurate methods are available to assess Zn deficiency. KW - Diabetes KW - Glucose KW - Metabolism KW - Supplements KW - Zinc KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dextrose KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of vitamin-A status on hamster tracheal epithelium in vivo and in vitro. AU - Luca, L. M. de AU - McDowell, E. M. JO - Food and Nutrition Bulletin JF - Food and Nutrition Bulletin Y1 - 1989/// VL - 11 IS - 3 SP - 20 EP - 24 SN - 0379-5721 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MS, USA. N1 - Accession Number: 19901425378. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - How vitamin A and the retinoids control epithelial morphology and function is reviewed particularly in regard to the tracheal epithelium of the Syrian golden hamster. The new concept of extrophic cells, i.e., cells that have conditionally escaped the need for an essential nutrient, such as vitamin A, is suggested. These exotrophs might become fixed by a mutation and eventually contribute to the tumorigenic phenotype. KW - epithelium KW - morphology KW - Retinoids KW - Retinol KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - vitamin A KW - vitamin A alcohol KW - vitamin A compounds KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425378&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Research priorities and strategies for investigation of the influence of vitamin-A supplementation on morbidity. AU - Forman, M. R. JO - Food and Nutrition Bulletin JF - Food and Nutrition Bulletin Y1 - 1989/// VL - 11 IS - 3 SP - 25 EP - 35 SN - 0379-5721 AD - Forman, M. R.: Cancer Prevention Studies Branch, National Cancer Institute, Rockville, MD, USA. N1 - Accession Number: 19901425379. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Recent clinical and field research in vitamin A and morbidity is reviewed and the epidemiologic evidence for the association between vitamin A deficiency and morbidity is examined. KW - epidemiology KW - morbidity KW - Retinol KW - reviews KW - Vitamin A deficiency KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - hypovitaminosis A KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425379&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ethical issues related to nutrition field trials. AU - Porter, J. P. JO - Food and Nutrition Bulletin JF - Food and Nutrition Bulletin Y1 - 1989/// VL - 11 IS - 3 SP - 36 EP - 40 SN - 0379-5721 AD - Porter, J. P.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19901425380. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Fundamental ethical principles related to nutrition field trials, provisions of the USA federal regulations for the protection of human subjects, and deliberations of the Subcommittee on Vitamin A Deficiency Prevention and Control regarding ethical concerns in studies on vitamin A are reviewed. KW - ethics KW - research KW - Retinol KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - studies KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425380&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Underpinning vitamin-A deficiency prevention and control programmes. AU - Underwood, B. A. JO - Food and Nutrition Bulletin JF - Food and Nutrition Bulletin Y1 - 1989/// VL - 11 IS - 3 SP - 41 EP - 42 SN - 0379-5721 AD - Underwood, B. A.: National Eye Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19901425381. Publication Type: Journal Article. Language: English. Number of References: 1 ref. Subject Subsets: Human Nutrition N2 - From a discussion of vitamin A deficiency prevention and control programmes it is concluded that until a demand for a programme or a product is created, i.e. convert programme recipients into programme consumers, whether for a high-dose capsule, lower-cost green leafy vegetables or better means of preparing and preserving foods rich in vitamin A for young children, it is difficult to conceive of achieving the effective sustained behavioural change that must occur to eradicate and control vitamin A deficiency. KW - prevention KW - treatment KW - Vitamin A deficiency KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypovitaminosis A KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425381&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical and biophysical studies on schistosomal liver of mice. AU - El-Aaser, A. AU - El-Merzabani, M. M. AU - Zakhary, N. I. AU - Farag, H. I. AU - Abdeen, A. M. AU - El-Salam, I. A. AU - Mokhtar, N. M. JO - Egyptian Journal of Bilharziasis JF - Egyptian Journal of Bilharziasis Y1 - 1989/// VL - 11 IS - 1-2 SP - 19 EP - 33 AD - El-Aaser, A.: Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 19930807782. Publication Type: Journal Article. Language: English. Language of Summary: Arabic. Number of References: 35 ref. Subject Subsets: Helminthology N2 - The quantity and rates of synthesis of nucleic acids, lipids, proteins and carbohydrates in liver homogenates of 60 Swiss albino mice infected sc with 70-100 Schistosoma mansoni cercariae and 60 uninfected controls, were determined. In infected mice there was a significant increase in DNA content and synthesis, determined by ³H-thymidine incorporation, whereas RNA levels and rate of synthesis were unchanged. Significant changes were also observed in the enzymes (5′ nucleotidase, alkaline phosphatase, acid phosphatase, acid ribonuclease) involved in nucleic acid metabolism. There was no change in the level of hepatic total lipids and phospholipids in infected mice although a decrease in cholesterol levels was observed. The rate of lipid synthesis was significantly increased whereas that of phospholipids was reduced. A reduction in glucose-6-phosphatase and glycogen levels was observed in the liver of infected mice which was restored following thyroxine treatment, indicating that thyroxine receptors are not affected by schistosomiasis. Total liver proteins and rate of synthesis were not altered in infected mice, although aspartate and alanine aminotransferase activities were increased. KW - disease models KW - experimental infections KW - helminths KW - laboratory animals KW - liver KW - parasites KW - pathology KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - N-acetyltransferase activity in bilharzial infested mice. AU - Zakhary, N. I. AU - Dahawy, H. S. AU - El-Aaser, A. A. JO - Egyptian Journal of Bilharziasis JF - Egyptian Journal of Bilharziasis Y1 - 1989/// VL - 11 IS - 1-2 SP - 165 EP - 169 AD - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 19930807801. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Helminthology N2 - The effect of Schistosoma haematobium infection on N-acetyltransferase enzyme systems was examined by estimating the percentage of N-acetylation of sulfadiazine-HCl (10 mg administered orally) in serum, liver and duodenal homogenates of S. haematobium infected albino mice. N-acetylation was significantly decreased in infected mice compared with the controls, and this is thought to indicate that schistosomal infection increases susceptibility to arylamine carcinogenesis. In both infected and control mice, liver homogenates showed the highest N-acetylation activity. KW - duodenum KW - experimental infections KW - helminths KW - laboratory animals KW - liver KW - parasites KW - pathogenesis KW - serum KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma haematobium KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - acetyltransferase KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807801&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathophysiology of the Lyme disease spirochete, Borrelia burgdorferi, in ixodid ticks. AU - Burgdorfer, W. AU - Hayes, S. F. AU - Corwin, D. A2 - Andriole, V.T. JO - Reviews of Infectious Diseases JF - Reviews of Infectious Diseases Y1 - 1989/// VL - 11 SP - S1442 EP - S1450 AD - Burgdorfer, W.: Laboratory of Pathobiology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19930518188. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The pathophysiology of B. burgdorferi is unique in tick/vector relationships, differing substantially from that of other spirochaetes, e.g. B. duttonii, the agent of tick-borne relapsing fever, and B. recurrentis, the agent of louse-borne relapsing fever, in their respective vectors. Following ingestion by a tick, B. burgdorferi lodges in the midgut diverticula, in some instances penetrating the gut wall and invading various tissues. Certain investigators suggest that transmission of the spirochaete occurs via infectious saliva, although, in light of the fact that only 5% of adult ticks are systemically infected, this mechanism is open to question. Alternatively, transmission may occur via periodic regurgitation of gut fluids during the feeding process. KW - disease transmission KW - Disease vectors KW - host parasite relationships KW - Infections KW - Transmission KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodes KW - Ixodidae KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodidae KW - Metastigmata KW - Acari KW - bacterium KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevention of Pneumocystis carinii pneumonia. AU - Masur, H. JO - Reviews of Infectious Diseases JF - Reviews of Infectious Diseases Y1 - 1989/// VL - 11 SP - S1664 EP - S1668 AD - Masur, H.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19920880619. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - Prophylaxis against P. carinii pneumonia (PCP) is reviewed. Target populations include those with human immunodeficiency virus infection, recent recipients of bone marrow or solid organ transplants, children with acute lymphocytic leukaemia and adults with T-cell leukaemia. The use of trimethoprim-sulfamethoxazole, pyrimethamine-sulfadoxine, and aerosolized pentamidine given once or twice monthly is discussed. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiprotozoal agents KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pentamidine KW - prophylaxis KW - transplantation KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - pyrimethamine sulfadoxine KW - trimethoprim sulfamethoxazole KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920880619&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The time course of sensory-specific satiety. AU - Hetherington, M. AU - Rolls, B. J. AU - Burley, V. J. JO - Appetite JF - Appetite Y1 - 1989/// VL - 12 IS - 1 SP - 57 EP - 68 SN - 0195-6663 AD - Hetherington, M.: National Institute of Mental Health, Section of Biomedical Psychiatry, Building 10, Room 3S231, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417624. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - The time course of the changes in hedonic response after ingestion of 3 different foods was investigated. Normal weight, non-dieting female subjects rated the pleasantness of the appearance, smell, texture and taste of 9 foods and then consumed as much as they wanted of cheese on cracker, tomato soup or orange jelly. After this first course, subjects re-rated the pleasantness of the foods at 2, 20, 40 and 60 min. After the 60-min rating, subjects were offered a second course of cheese on cracker or chocolate bar. For all sensory variables measured and for all foods consumed, the greatest decline in pleasantness occurred for the eaten food 2 min after consumption. For the food rated as most palatable (cheese on cracker) there was some recovery of pleasantness of the texture and taste over the hour. Intake in the second course was similar regardless of whether the food offered was different or the same as the food consumed in the first course. As changes in the pleasantness of the foods occurred rapidly for all sensory variables studied and as the magnitude of these changes did not increase over time, it is concluded that the development of sensory-specific satiety is related primarily to the sensory stimulation accompanying ingestion as opposed to the postabsorptive effects of consuming these foods. KW - Palatability KW - satiety KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417624&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Methionine lowers circulating levels of acetaldehyde after ethanol ingestion. AU - Tabakoff, B. AU - Eriksson, C. J. P. AU - Wartburg, J. P. von JO - Alcoholism: Clinical and Experimental Research JF - Alcoholism: Clinical and Experimental Research Y1 - 1989/// VL - 13 IS - 2 SP - 164 EP - 171 SN - 0145-6008 AD - Tabakoff, B.: National Institute on Alcohol Abuse and Alcoholism/NIH, Building 10, Room 3C103, Bethesda, MD 20892, USA. N1 - Accession Number: 19901450349. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 75-07-0, 64-17-5, 63-68-3. Subject Subsets: Human Nutrition N2 - When methionine was given to mice and rats which had been treated with ethanol there was a significant decrease in circulating acetaldehyde without change in circulating values of ethanol. Acetaldehyde values in liver were also decreased by methionine. Methionine was effective when given before or after the administration of ethanol, but the time course of the action of methionine suggested the necessity for metabolic transformation of the amino acid in order for the acetaldehyde-lowering effect to appear. Studies with healthy men and women, given methionine doses relatively of about one-tenth of those used with mice, indicated that methionine can also decrease acetaldehyde in persons ingesting ethanol. Given the toxic characteristics of acetaldehyde, methionine may prove effective in reducing the damaging effects of ethanol ingestion. KW - Acetaldehyde KW - blood KW - ethanol KW - methionine KW - animals KW - man KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - ethyl alcohol KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450349&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunocytochemical studies with antibodies to three proteins prominent in the isolated microtubule cytoskeleton of a trypanosomatid. AU - Bramblett, G. T. AU - Kambadur, R. AU - Flavin, M. JO - Cell Motility and the Cytoskeleton JF - Cell Motility and the Cytoskeleton Y1 - 1989/// VL - 13 IS - 3 SP - 145 EP - 157 SN - 0886-1544 AD - Bramblett, G. T.: M. Flavin, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room B1-22, MD 20892, USA. N1 - Accession Number: 19900860878. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology N2 - The cytoskeleton of Crithidia fasciculata consists of a corset of parallel microtubules enclosing the cell body and closely underlying the plasma membrane. Distinct sets of crosslinks appear to connect tubules to each other and to the membrane. To determine the composition of these crosslinks and to elucidate the basis of this spectacular example of membrane-microtubule interaction, 3 proteins (designated COP-33, -41, and -61 by their subunit MW), which were consistently abundant in highly purified cytoskeletons, were purified. All bound strongly to microtubules in vitro, and the first 2 induced bundles through periodic crosslinking. Polyclonal antibodies against each were used to localize these proteins in thin sections of cells or whole mounts of cytoskeletons. Antibodies to COP-41 bound specifically to glycosomes, and COP-41 was identified as glyceraldehyde 3-P dehydrogenase. KW - biochemistry KW - cytoskeleton KW - microtubules KW - parasites KW - proteins KW - ultrastructure KW - Crithidia fasciculata KW - protozoa KW - Sarcomastigophora KW - Crithidia KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900860878&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantification of the putative neurotoxin 2-amino-3-(methylamino)propanoic acid (BMAA) in Cycadales: analysis of the seeds of some members of the family Cycadaceae. AU - Duncan, M. W. AU - Kopin, I. J. AU - Crowley, J. S. AU - Jones, S. M. AU - Markey, S. P. JO - Journal of Analytical Toxicology JF - Journal of Analytical Toxicology Y1 - 1989/// VL - 13 IS - 3 SP - 169 EP - 175 SN - 0146-4760 AD - Duncan, M. W.: Intramural Research Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417580. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition KW - neurotoxins KW - seeds KW - Cycadaceae KW - Cycadopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Food Contamination, Residues and Toxicology (QQ200) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417580&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol consumption and breast cancer: a cross-national correlation study. AU - Schatzkin, A. AU - Piantadosi, S. AU - Miccozzi, M. AU - Bartee, D. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1989/// VL - 18 IS - 1 SP - 28 EP - 31 SN - 0300-5771 AD - Schatzkin, A.: Division of Cancer Prevention and Control, National Cancer Institute, Blair Building, Room 6A-01, 9000 Rockville Pike, Bethesda, MA 20892, USA. N1 - Accession Number: 19901419482. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition; Public Health N2 - The cross-national correlation of alcohol consumption (based on food availability data from the Food and Agriculture Organization) and breast cancer was examined. Weighted correlation coefficients for alcohol and breast cancer were 0.31 for mortality and 0.65 for incidence; the corresponding unweighted coefficients were 0.50 and 0.45. Correlation coefficients for fat consumption and breast cancer ranged from 0.69 to 0.89. After adjustment for fat consumption in multiple regression models, the positive alcohol/breast cancer association disappeared, while the fat/breast cancer correlation remained positive and strong. These findings do not support the positive alcohol/breast cancer association that has been suggested by analytical epidemiological studies. The multivariate results, however, should be interpreted with caution due to the potential variation in the extent to which national alcohol data reflect consumption among females. KW - alcohol intake KW - alcoholic beverages KW - alcohols KW - breast KW - Carcinoma KW - health KW - mammary glands KW - neoplasms KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - alcohol consumption KW - breasts KW - cancer sites KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419482&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinical trials in diet and cancer. AU - Byar, D. P. AU - Freedman, L. S. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1989/// VL - 18 IS - 2 SP - 203 EP - 219 SN - 0091-7435 AD - Byar, D. P.: Biometry Branch, Executive Plaza North, Room 344, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911439396. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - The proposed plans for the Womens Health Trial, a dietary intervention trial aimed at reducing fat intake to 20% of energy intake, are described. The problems of using case-control and cohort studies to judge the plausibility of dietary hypotheses are discussed, and the advantages of randomized intervention trials are highlighted. KW - carcinoma KW - fats KW - intake KW - prevention KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911439396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human dietary assessment: methods and issues. AU - Block, G. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1989/// VL - 18 IS - 5 SP - 653 EP - 660 SN - 0091-7435 AD - Block, G.: Division of Cancer Prevention and Control, National Cancer Institute, EPN, Room 313, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19921443969. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - It is possible that a "good" diet may increase response to a chemopreventive agent, or that a diet deficient in some nutrients may weaken host defences or host response to the agent. Thus, dietary intake should be assessed in chemoprevention as well as dietary studies. The advantages and disadvantages of several methods are presented. Studies should attempt to assess the whole diet, not one or a few nutrients. Interpretation of the results of dietary studies can be seriously flawed and conclusions incorrect if only one or a few nutrients are assessed. Studies that ask about vegetable products but calculate only a fibre index are forced into drawing conclusions about fibre, when the true effective component may be elsewhere. Investigators should be cautious in the analysis and interpretation of results involving correlated nutrients. If variables are quite highly correlated, positively or negatively, a nutrient which has no effect may seem to have one, merely by correlation. Some examples are presented. Misclassification or measurement error is a serious problem for all dietary methods. For most frequency or few-day-record methods, sample sizes must be multiplied to accommodate measurement error. KW - Diet study techniques KW - Disease prevention KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443969&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A brief dietary screen for high fat intake. AU - Block, G. AU - Clifford, C. AU - Naughton, M. D. AU - Henderson, M. AU - McAdams, M. JO - Journal of Nutrition Education JF - Journal of Nutrition Education Y1 - 1989/// VL - 21 IS - 5 SP - 199 EP - 207 SN - 0022-3182 AD - Block, G.: Executive Plaza North, Room 313, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417510. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 12 ref. Subject Subsets: Human Nutrition N2 - A 13-item questionnaire was developed to identify groups with a high or low fat intake. It is intended as a rapid screening tool to identify those who may benefit from counselling or who could then be subjected to a more definitive dietary assessment. It may be self- or interviewer-administered. A correlation of r = 0.58 was observed between g total fat as estimated by the 13-item screener and g total fat as calculated from the mean of three 4-day diet records, among 101 women 45 years or more old. By dividing the screener fat distribution at its midpoint, 2 groups are identified which have 41 and 35% of energy from fat by diet records. The 13-item screener does nearly as well as 4-day diet record in correctly identifying those above and below the group's midpoint in percentage of energy from fat. KW - Fats KW - intake KW - screening KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - screening tests KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417510&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle. AU - Katz, A. AU - Nyomba, B. L. AU - Bogardus, C. JO - International Journal of Biochemistry JF - International Journal of Biochemistry Y1 - 1989/// VL - 21 IS - 10 SP - 1079 EP - 1082 SN - 0020-711X AD - Katz, A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19901417963. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - The effects of physiological concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact skeletal muscle of 7 healthy men 19 to 28 years old were studied. Insulin increased glucose 1,6-P2 from a basal value of 70 ± 6 to 135 ± 12 μmol/kg dry weight. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, inorganic phosphorus or citrate) or its substrate glucose 6-phosphate. KW - blood KW - insulin KW - Skeletal muscle KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - glucose 1,6-bisphosphate KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of DNA hybridization probes for detection of the plague bacillus (Yersinia pestis) in fleas (Siphonaptera: Pulicidae and Ceratophyllidae). AU - Thomas, R. E. AU - McDonough, K. A. AU - Schwan, T. G. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1989/// VL - 26 IS - 4 SP - 342 EP - 348 SN - 0022-2585 AD - Thomas, R. E.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19900597165. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - The detection of active plague in nature relies primarily on demonstration of the aetiologic agent of the disease, Y. pestis, in the flea vectors and susceptible mammalian hosts. A live animal assay is currently used for identification of a Y. pestis virulence antigen that is not expressed in the flea. It was found that DNA hybridization probes specific for Y. pestis, used in very simple sample preparation schemes, allow detection of Y. pestis in 3 species of fleas as well as tissues of experimentally infected mice at minimum concentrations of 1×106 bacillus/ml. Y. pestis was detected in 22 of 90 (24%) experimentally infected Xenopsylla cheopis, 13 of 25 (52%) Thrassis bacchi and 9 of 25 (36%) Diamanus montanus [Oropsylla montana], but no hybridization signals were observed from fleas that had fed on uninfected mice. The probe technique indicated infection in 9 of 10 potentially infected liver and spleen samples and none of the 5 control samples. The techniques permit definite diagnosis in 48 h. KW - Biotechnology KW - detection KW - Diagnosis KW - DNA probes KW - Infections KW - Laboratory animals KW - Plague KW - Techniques KW - vectors KW - Bacteria KW - Ceratophyllidae KW - Diamanus KW - Diamanus montanus KW - Mice KW - Oropsylla KW - Pulicidae KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - prokaryotes KW - Siphonaptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Ceratophyllidae KW - Xenopsylla KW - Pulicidae KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - Diamanus KW - Oropsylla KW - bacterium KW - Oriental rat flea KW - Oropsylla montana KW - Thrassis bacchi KW - Yersinia pseudotuberculosis subsp. pestis KW - Techniques and Methodology (ZZ900) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597165&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Taxonomic clarification of Cladosporium trichoides Emmons and its subsequent synonyms. AU - Kwon-Chung, K. J. AU - Wickes, B. L. AU - Plaskowitz, J. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1989/// VL - 27 IS - 6 SP - 413 EP - 426 SN - 0268-1218 AD - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901205635. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A herbarium specimen of C. bantianum was compared with a herbarium specimen and a living type culture of C. trichoides by light and scanning electron microscopy (SEM) and was found to be dissimilar. Herbarium specimens and living cultures of Xylohypha nigrescens, the type species of the genus Xylohypha, were also compared with those of C. trichoides and other pathogenic Cladosporium spp. Fundamental differences were found between X. nigrescens and Cladosporium spp., in colony morphology, manner of sporulation and conidial morphology. All Cladosporium isolates produced olive-black colonies regardless of environmental conditions, bore brown pigment on the walls of the vegetative hyphae as well as on the walls of the fruiting structures and produced branched chains of conidia either from well differentiated or poorly differentiated conidiophores, or directly from the hyphae. By SEM, conidia showed strong to moderately protruded hila and the basal contour of the conidia was always truncated. On germination, hyphal tubes were produced randomly from the surface of the conidia. In contrast, X. nigrescens produced white colonies with or without brown centres, depending on the culture medium, bore pigment on the conidial walls and on conidiogenous cells but not on the vegetative hyphae and produced infrequently branched conidial chains, usually from intercalary conidiogenous cells which were globose to hat-shaped. Conidial hila were nonprotruding but, instead, were deeply concave and pore-like. The basal contour of the conidia was round and germ tubes were produced only from the pore-like hila. It is concluded that C. trichoides is different from C. bantianum and that the reclassification of C. trichoides into the genus Xylohypha was not warranted. KW - taxonomy KW - Cladophialophora bantiana KW - Cladophialophora KW - Herpotrichiellaceae KW - Chaetothyriales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Xylohypha KW - fungus KW - Hyphomycetes KW - systematics KW - Xylohypha bantiana KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205635&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modified magnesium method in the aca III: elimination of interference by bilirubin. AU - Rehak, N. N. AU - Chiang, B. T. JO - Clinical Chemistry JF - Clinical Chemistry Y1 - 1989/// VL - 35 IS - 6 SP - 1031 EP - 1033 SN - 0009-9147 AD - Rehak, N. N.: Warren Grant Magnuson Clinical Center, Clinical Chemistry Service, Clinical Pathology Department, National Institutes of Health, Building 10, Room 2C-407, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418735. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 7439-95-4. Subject Subsets: Human Nutrition N2 - Bilirubin interferes with the Du Pont magnesium method in the aca at 510 nm. It was determined that bilirubin concentrations in serum samples up to 380 mg/litre did not affect the absorbance measured in the aca III at 540 nm, and therefore the Du Pont setting of spectrophotometer for the Mg method was modified to 540 and 600 nm. Accuracy and precision of the modified method were similar to the unmodified method and to atomic absorption spectrophotometry. For comparison, 37 serum samples with normal and 22 with increased bilirubin concentration were analysed with the modified method in the aca III and in the atomic absorption spectrophotometer. The results (range 0.56 to 1.25 mmol/litre) were in good agreement and bilirubin did not interfere with the modified method. KW - blood KW - estimation KW - Magnesium KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418735&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinical studies of Pneumocystis carinii and relationships to AIDS. AU - Masur, H. JO - Journal of Protozoology JF - Journal of Protozoology Y1 - 1989/// VL - 36 IS - 1 SP - 70 EP - 74 AD - Masur, H.: Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900859740. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology N2 - The diagnosis, chemotherapy and prophylaxis of P. carinii infection in AIDS patients is discussed. KW - Acquired immune deficiency syndrome KW - diagnosis KW - DRUG THERAPY KW - Human diseases KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - prophylaxis KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - chemotherapy KW - fungus KW - general account KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900859740&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of antigens specific for Pneumocystis carinii. AU - Kovacs, J. A. AU - Lundgren, B. AU - Masur, H. JO - Journal of Protozoology JF - Journal of Protozoology Y1 - 1989/// VL - 36 SP - 67S EP - 69S AD - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19890859790. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology N2 - Antigens specific for rat P. carinii and for human P. carinii were identified using polyclonal sera from immunized animals or from patients with P. carinii pneumonia. The most prominent bands seen in rat P. carinii preparations were an antigen of approximately 100 000 MW and a broad band ranging from 49-64 000 MW. The most prominent bands seen with the human P. carinii preparations included 2 bands of 22 and 24 000 MW and a broad band of 35-45 000 MW. Bands of 64, 75 and 100 000 MW were also seen. Sera obtained from 33 (human) adults were treated for P. carinii antibodies by immunoblotting. Antibodies were detected in 32 of 33 serum samples, including 7 from healthy people, 6 from patients with AIDS but no history of P. carinii pneumonia, and 10 from patients without AIDS but with a history of P. carinii pneumonia. Antibodies were detected in one of 8 children who were hospitalized for diarrhoea. Twenty of the 32 sera that contained antibodies against human P. carinii contained anti-rat P. carinii antibodies. It is suggested that rat and human strains of P. carinii are antigenically distinct. Five monoclonal antibodies specific for human P. carinii were produced. Two reacted with all human isolates tested, and none with rat isolates. Using an anti-rat P. carinii monoclonal antibody, 4 patterns of reactivity with immunoblot were seen. Antigens of 40, 50, 57, 85 and 100 000 MW were identified for rat P. carinii. Antibodies invariably reacted with more than one antigen. Using the anti-human P. carinii monoclonal antibodies, antigens of 22, 24, 65, 67 and 95 000 MW were seen. By immunoblot, only one monoclonal antibody, antibody 7D7, reacted with both rat and human P. carinii. This was the only antibody that reacted with both rat and human P. carinii by immunofluorescence. The monoclonal antibodies 7d7, 2G2 and 6B8 were found to identify 90% of patients with P. carinii when used in immunofluorescent assays. KW - antigens KW - Biotechnology KW - characterization KW - Human diseases KW - Immunocompromised hosts KW - Laboratory animals KW - monoclonal antibodies KW - Opportunistic infections KW - parasites KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Rodents KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - mammals KW - vertebrates KW - Chordata KW - antigenicity KW - fungus KW - immunogens KW - rat strain differences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859790&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of rat liver microsomal and nuclear cytochrome P-450 by dietary 2-acetylaminofluorene and butylated hydroxytoluene. AU - Friedman, F. K. AU - Miller, H. AU - Park, S. S. AU - Graham, S. A. AU - Gelboin, H. V. AU - Carubelli, R. JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1989/// VL - 38 IS - 18 SP - 3075 EP - 3081 SN - 0006-2952 AD - Friedman, F. K.: National Cancer Institute, Building 37, Room 3E24, Bethesda, MD 20892, USA. N1 - Accession Number: 19911430167. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9035-51-2, 128-37-0. Subject Subsets: Human Nutrition N2 - The influence of dietary 2-acetylaminofluorene (AAF) on the cytochrome P-450 content of rat liver microsomal and nuclear fractions was immunochemically probed with monoclonal and polyclonal antibodies to cytochromes P-450c and P-450d. Cytochrome P-450d but not P-450c was immunodetected in microsomes, nuclear envelopes and nuclei from untreated rats. Values of cytochromes P-450c and P-450d were increased after a diet of 0.1% AAF for one week or 0.05% AAF for 3 weeks. Value of cytochrome P-450c relative to P-450d was lower after the more prolonged AAF feeding. Supplementation of AAF-containing diets with 0.3% butylated hydroxytoluene (BHT), which affords protection against AAF hepatocarcinogenesis in rats given diets high in fat, protected and/or induced total (spectral) nuclear envelope cytochrome P-450 content. Immunochemical studies of liver fractions showed that BHT enhanced the AAF-dependent induction of cytochrome P-450c, but not of P-450d. This was a concerted effect of AAF plus BHT since dietary BHT by itself did not affect the values of cytochrome P-450c or P-450d as compared with those in controls. Since 1- to 3-week dietary AAF had little effect on total (spectral analyses) microsomal cytochrome P-450 but reduced total P-450 in nuclear envelopes, the coordinated induction of specific cytochrome P-450s in the different fractions suggests selective induction and depression of different forms of cytochrome P-450 and provides additional evidence for independent regulation of the drug-metabolizing system in nuclear envelope and microsomes. The results suggest that regulation of cytochrome P-450 may play a crucial role in the nutritional modulation of AAF hepatocarcinogenesis. KW - butylated hydroxytoluene KW - Cytochrome P-450 KW - induction KW - liver KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - acetylaminofluorene KW - BHT KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430167&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Persistance of hepatic fibrosis and tissue eggs following treatment of Schistosoma japonicum infected mice. AU - Cheever, A. W. AU - Deb, S. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1989/// VL - 40 IS - 6 SP - 620 EP - 628 SN - 0002-9637 AD - Cheever, A. W.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930804311. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 26328-53-0, 55268-74-1. Subject Subsets: Helminthology N2 - The persistence of hepatic fibrosis and of Schistosoma japonicum eggs in the tissues of mice was examined after chemotherapy. C57BL/6 mice infected with a Philippine strain of S. japonicum were tested with praziquantel or amoscanate 7 or 8 weeks after infection. Groups of mice were killed at the time of treatment and 3, 8, 26 and 52 weeks later. The number of eggs per worm pair in the tissues did not change during the year after treatment. However, S. japonicum eggs injected into the tail vein were gradually destroyed in the lungs. Hepatic fibrosis increased in the first few weeks after treatment and did not change significantly thereafter. Praziquantel, but not amoscanate, had an immediate toxic effect on the most mature eggs in the tissues which was accompanied by a marked but transient decrease in eggs passed in the faeces. Less mature eggs appeared unaffected by the drug and the passage of eggs in the faeces resumed as these matured. Egg passage then ceased as the supply of viable eggs was exhausted. KW - Amoscanate KW - Anthelmintics KW - drug therapy KW - Experimental infections KW - helminths KW - Human diseases KW - Laboratory animals KW - parasites KW - pathology KW - Praziquantel KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma japonicum KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - chemotherapy KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential non-responsiveness in humans of candidate Plasmodium falciparum vaccine antigens. AU - Quakyi, I. A. AU - Otoo, L. N. AU - Pombo, D. AU - Sugars, L. Y. AU - Menon, A. AU - DeGroot, A. S. AU - Johnson, A. AU - Alling, D. AU - Miller, L. H. AU - Good, M. F. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1989/// VL - 41 IS - 2 SP - 125 EP - 134 SN - 0002-9637 AD - Quakyi, I. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864587. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology N2 - Using sera of 35 adults and 50 children from the The Gambia, West Africa, where P. falciparum is highly endemic, the humoral immune response to candidate malaria vaccine antigens from sporozoites, merozoites, and gametes was examined. Widespread restricted immunogenicity to defined parasite antigens was observed in children and adults. HLA typing of adult lymphocytes demonstrated a marked diversity in HLA haplotypes in this population. These results and those from previous studies in mice suggest that genetic factors may partly explain the immunological non-responsiveness. This may necessitate re-evaluation of the malaria vaccine strategy. KW - Human diseases KW - immune response KW - parasites KW - synthetic vaccines KW - Vaccines KW - Africa KW - Gambia KW - Apicomplexa KW - man KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - immunity reactions KW - immunological reactions KW - The Gambia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864587&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Filariasis now. AU - Ottesen, E. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1989/// VL - 41 IS - 3, II SP - 9 EP - 17 SN - 0002-9637 AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862776. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Subject Subsets: Helminthology N2 - Progress made in lymphatic filariasis research with particular reference to immunology, immunopathology, immunoregulation and immunity is reviewed. KW - Filariids KW - helminths KW - Human diseases KW - immunity KW - immunopathology KW - parasites KW - reviews KW - man KW - Nematoda KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - immunopathogenesis KW - nematodes KW - parasitic worms KW - Parasitology Then and Now KW - Paul C. Beaver Symposium KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862776&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of vitamin D deficiency on macrophage and lymphocyte function in the rat. AU - Wientroub, S. AU - Winter, C. C. AU - Wahl, S. M. AU - Wahl, L. M. JO - Calcified Tissue International JF - Calcified Tissue International Y1 - 1989/// VL - 44 IS - 2 SP - 125 EP - 130 SN - 0171-967X AD - Wientroub, S.: L.M. Wahl, Laboratory of Microbiology and Immunology, Building 30, Room 325, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901452891. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 67-97-0. Subject Subsets: Human Nutrition N2 - Rats deprived of cholecalciferol in utero and in postnatal life had significantly reduced thymocyte or splenocyte [³H]thymidine incorporation to mitogens and decreased macrophage chemotaxis when compared with cholecalciferol-sufficient rats. Secretion of soluble mediators, including interleukin 2 by lymphocytes and interleukin 1 and PGE2 by macrophages, was not affected by vitamin D deficiency. KW - Cholecalciferol KW - deficiency KW - lymphocytes KW - macrophages KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin D3 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452891&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relevance of basophil histamine release changes during venom immunotherapy. AU - Stephan, V. AU - Kühr, J. AU - Urbanek, R. JO - Allergy (Copenhagen) JF - Allergy (Copenhagen) Y1 - 1989/// VL - 44 IS - 7 SP - 453 EP - 459 SN - 0105-4538 AD - Stephan, V.: National Institutes of Health, Bldg. 10 Rm 1A 23, 9000 Rockville Place, Bethesda, MD 20982, USA. N1 - Accession Number: 19920500320. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 51-45-6. Subject Subsets: Medical & Veterinary Entomology N2 - The effect of rush and long-term venom immunotherapy on histamine release parameters in bee [Apis mellifera] venom allergic patients were investigated. 10 patients received rush venom immunotherapy, and histamine release data were obtained immediately before and after treatment. 17 patients were assessed by histamine release 24-63 months after termination of long-term venom immunotherapy. A control group of 10 non-allergic subjects was included in this study. Histamine released from whole blood was determined in a sensitive radio-enzymatic assay using a single isotope technique. Bee venom phospholipase A-induced histamine release from whole blood proved to be a test procedure of high specificity and sensitivity. 8 of 10 untreated patients and no control subjects showed significant antigen-induced histamine release. Results obtained from patients immediately after successful rush venom immunotherapy showed an important decrease (mean 45.9%) of total histamine content of basophils in all patients. Antigen-induced maximum histamine release was found to be increased in 1, decreased in 2 and unchanged in 7 patients. In patients who received long-term immunotherapy, cell sensitivity to phospholipase A was significantly lower than in a group of untreated patients. It is suggested that histamine depletion of basophils induced by rush immunotherapy may play an important role in patients' protection immediately after termination of the rush regimen. KW - Arthropod allergies KW - Basophils KW - Histamine KW - HONEY BEE VENOM KW - hypersensitivity KW - Immunotherapy KW - therapy KW - venoms KW - Apidae KW - Apis mellifera KW - Hymenoptera KW - man KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Apis KW - Apidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - allergic responses KW - honeybee venom KW - hypersensitiveness KW - therapeutics KW - venom KW - Non-communicable Human Diseases and Injuries (VV600) KW - Apiculture (LL010) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920500320&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of caffeine on social behavior, exploration and locomotor activity: interactions with ethanol. AU - Hilakivi, L. A. AU - Durcan, M. J. AU - Lister, R. G. JO - Life Sciences JF - Life Sciences Y1 - 1989/// VL - 44 IS - 8 SP - 543 EP - 553 SN - 0024-3205 AD - Hilakivi, L. A.: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Building 10 3C218, Bethesda, MD 20892, USA. N1 - Accession Number: 19891416365. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 58-08-2, 64-17-5. Subject Subsets: Human Nutrition N2 - The effects of caffeine and its interaction with ethanol were examined in a test of social behaviour and a holeboard test of exploration and locomotion. Male mice were injected intraperitoneally with caffeine 15, 30 or 60 mg/kg alone or in combination with ethanol 2 g/kg. The mice were then put in pairs into a familiar arena, or examined individually in the holeboard. Only the highest dose of caffeine had a significant effect on the time spent in social interaction and motor activity in the social behaviour test: both measures were reduced. The duration and frequency of avoidance-irritability behaviour was dose-dependently increased by caffeine. In the holeboard, caffeine caused a dose-dependent increase in locomotor activity. Caffeine 30 mg/kg reversed the ethanol-induced reduction of time spent in social interaction, and 60 mg/kg antagonized the ethanol-induced increase in locomotor activity in the social behaviour and holeboard tests. The effects of caffeine on ethanol-induced behavioural changes are compared with those of other drugs. KW - activity KW - behaviour KW - Caffeine KW - ethanol KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - ethyl alcohol KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891416365&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cell surface nanoanatomy of Leishmania major as revealed by fracture-flip. A surface meshwork of 44 nm fusiform filaments identifies infective developmental stage promastigotes. AU - Pimenta, P. F. P. AU - Silva, R. P. da AU - Sacks, D. L. AU - Silva, P. P. da JO - European Journal of Cell Biology JF - European Journal of Cell Biology Y1 - 1989/// VL - 48 IS - 2 SP - 180 EP - 190 SN - 0171-9335 AD - Pimenta, P. F. P.: P.P. Da Silva, Building 538, Room 104, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701, USA. N1 - Accession Number: 19900860810. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology N2 - Fracture-flip was used to reveal the nanoanatomy of the surface of L. major promastigotes. Over the cell surface of infective metacyclic promastigotes a meshwork of 44 nm long, fusiform filaments was identified. These filaments are not seen in non-infective stages of the parasite. Replica-staining immunocytochemistry with monoclonal antibody against infective metacyclic lipophosphoglycan shows a uniform distribution of protein A-colloidal gold complexes over the cell surface. Thin sections show that acquisition of the high molecular weight lipophosphoglycan is reflected in a thicker glycocalyx. Conventional freeze-fracture shows that, in infective metacyclic promastigotes, there is a reversal of the partition of intramembrane particles - an additional morphological marker for the infective developmental stage. It is hypothesized that the fusiform filaments represent metacyclic developmental lipophosphoglycan. KW - Human diseases KW - parasites KW - promastigotes KW - ultrastructure KW - Leishmania major KW - protozoa KW - Sarcomastigophora KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cell surface KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900860810&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oral contraceptives: effect of long-term use on liver vitamin A storage assessed by the relative dose response test. AU - Amatayakul, K. AU - Underwood, B. A. AU - Ruckphaopunt, S. AU - Singkamani, R. AU - Linpisarn, S. AU - Leelapat, P. AU - Thanangkul, O. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1989/// VL - 49 IS - 5 SP - 845 EP - 848 SN - 0002-9165 AD - Amatayakul, K.: B.A. Underwood, National Eye Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417207. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Vitamin A state estimated by the relative dose response (RDR) test was determined among groups of northern Thai women who had used oestrogen-containing oral contraceptives (OC) without or with multivitamin supplements during 13 cycles. Mean serum vitamin A values were 40% above those of control subjects (intrauterine contraceptive device users) during OC usage. Daily (one capsule) or periodic (2 capsules 7 days per month) multivitamin supplementation that included 1700 μg vitamin A per capsule did not significantly influence vitamin A serum values. The RDR test after 24 cycles was increased in one woman who had taken OC and the periodic multivitamin supplement. It reverted to normal after supplementation with vitamin A. A single high-dose vitamin A supplement (68 000 μg) did not change circulating values of the vitamin. Among this population there is little evidence that use of oestrogen-containing OC for more than 1 year resulted in a physiologically significant deterioration of vitamin A state. KW - liver KW - Oral contraceptives KW - retinol KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417207&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or β-carotene. AU - Luca, L. M. de AU - Shores, R. L. AU - Spangler, E. F. AU - Wenk, M. L. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1989/// VL - 49 IS - 19 SP - 5400 EP - 5406 SN - 0008-5472 AD - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Building 37, Room 3A-17, Bethesda, MD 20892, USA. N1 - Accession Number: 19911430031. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Vitamin A depletion was produced by giving female SENCAR mice a deficient diet at the birth of their young which were then weaned on the same diet. A single topical dose of 7,12-dimethylbenz(a)anthracene (DMBA) 20 µg was used as the initiator at 3 weeks of age and 12-O-tetradecanoylphorbol-13-acetate (TPA) 1 to 2 µg once weekly as the tumour promoter for 10 weeks (from week 4 to 13 of the experiment). 55% of mice (n = 40) on stock diet (mean body weight, 31.4 g) developed skin tumours (2.58 per mouse) at 12 weeks compared with 2.5% (0.05 papillomas per mouse) of mice (n = 40) kept on the purified vitamin A-deficient diet (mean body weight, 30.3 g), a 98% decrease in tumour/mouse. Retinoic acid (RA) (1-3 µg/g diet) supplementation after week 12 caused a rapid tumourigenic response in 95% of the mice by week 22. Even though tumour incidence increased within 1 week of RA and 95% of the mice showed the tumourigenic response, the number of tumours per mouse was about 50% of that observed in mice maintained on standard stock diet. It was concluded that physiological amounts of retinoids or their carotenoid precursor are necessary for DMBA-initiated, TPA-promoted tumour formation in the skin of female SENCAR mice. KW - Carcinoma KW - carotenoids KW - deficiency KW - retinol KW - skin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - dermis KW - tetraterpenoids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430031&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The cell surface of Trypanosoma cruzi: a fracture-flip, replica-staining label-fracture survey. AU - Pimenta, P. F. P. AU - Souza, W. de AU - Souto-Padrón, T. AU - Silva, P. P. da JO - European Journal of Cell Biology JF - European Journal of Cell Biology Y1 - 1989/// VL - 50 IS - 2 SP - 263 EP - 271 SN - 0171-9335 AD - Pimenta, P. F. P.: P.P. da Silva, Membrane Biology Section, Laboratory of Mathematical Biology, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701-1013, USA. N1 - Accession Number: 19910869189. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology N2 - Fracture-flip and replica-staining label-fracture were used to study the nanoanatomy and topochemistry of the cell surface of T. cruzi. Fracture-flip surface images differentiate the 3 main developmental stages of T. cruzi. Epimastigotes display a smooth surface, except the cytostome which appears as a clearly demarcated, raised, roughly textured platform. Amastigotes and trypomastigotes are covered by numerous surface particles with diameters ranging from 10 to 20 nm and 15 to 30 nm, respectively. Labelling of concanavalin A receptors showed that the surfaces of amastigotes and trypomastigotes were labelled, with amastigotes displaying the highest density of gold particles. In contrast, epimastigotes were sparsely labelled with exception of the cytostome, where a higher density of labelling coincided with the raised platform seen in fracture-flipped specimens, and with the particle-free area exposed on fracture faces. Labelling of epimastigotes by Ricinus communis I and Wistaria floribunda lectins showed that surface receptors for these lectins were absent from the cytostome. KW - Human diseases KW - parasites KW - ultrastructure KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - cell surface KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869189&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional factors in diabetics with and without retinopathy. AU - Roy, M. S. AU - Stables, G. AU - Collier, B. AU - Roy, A. AU - Bou, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1989/// VL - 50 IS - 4 SP - 728 EP - 730 SN - 0002-9165 AD - Roy, M. S.: National Eye Institute, Building 10, Room 10C410, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418101. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - To examine nutritional factors in diabetic patients with and without retinopathy 3-day food records were used. Patients without retinopathy had significantly higher daily intakes of total carbohydrate, water-soluble dietary fibres, insoluble dietary fibres and glucose than did patients with retinopathy. Patients without retinopathy took a significantly lower proportion of their total daily energy as protein. KW - Diabetes KW - nutrition KW - retinopathy KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418101&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Issues in reproducibility and validity of dietary studies. AU - Block, G. AU - Hartman, A. M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1989/// VL - 50 SP - 1133 EP - 1138 SN - 0002-9165 AD - Block, G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Executive Plaza North, Room 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418368. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - Numerous factors affect the reproducibility and validity of dietary assessment questionnaires. Although the respondents' abilities to respond accurately are most frequently discussed as the cause of apparently poor reproducibility and validity, many other factors are as important and perhaps more important. Most of these other factors are under the control of the investigator and thus are amenable to improvement. Factors which may affect reproducibility include the degree of variability permitted by the instrument, the error-proneness of the response format, quality control of coding and keying, and real dietary change in the time between the 2 administrations of the questionnaire. Factors affecting real or apparent validity include respondent characteristics, questionnaire design and quantification, quality control, and the adequacy of the reference data. The implications of inadequate reference data are illustrated and discussed. KW - Diet study techniques KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418368&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Novel pyrrolidines in the venom of the ant Monomorium indicum. AU - Jones, T. H. AU - Blum, M. S. AU - Escoubas, P. AU - Ali, T. M. M. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1989/// VL - 52 IS - 4 SP - 779 EP - 784 SN - 0163-3864 AD - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19910504362. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology N2 - New 2,5-dialkylpyrrolidines found in the venom of M. indicum (from Karnataka, India) include trans-2-butyl-5-(4-pentenyl)pyrrolidine, trans-2-butyl-5-(6-heptenyl)pyrrolidine, trans-5-(5-hexenyl)-2-(4-pentenyl)pyrrolidine, trans-5-(6-petenyl)-2-(5-hexenyl)pyrrolidine and trans-5-hepty-2-hexylpyrrolidine, whose structures were confirmed by synthesis. The concomitance of 5 previously reported trans-2,5-dialkyl-pyrrolidines along with small amounts of the cis isomers and N-methyl analogues makes the venom of M. indica the most qualitatively diverse blend of alkaloids reported from an ant to date. The toxicities to termites (Reticulitermes clavipes) of 4 of these alkaloids were determined. KW - agricultural entomology KW - Alkaloids KW - animal physiology KW - Biochemistry KW - Insect pests KW - pyrrolidine alkaloids KW - Toxicity KW - Toxins KW - venoms KW - India KW - Karnataka KW - arthropods KW - Formicidae KW - Hymenoptera KW - insects KW - Isoptera KW - Rhinotermitidae KW - invertebrates KW - animals KW - eukaryotes KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - Isoptera KW - Monomorium KW - Formicidae KW - Reticulitermes KW - Rhinotermitidae KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - Monomorium indicum KW - Mysore KW - pest insects KW - pyrrolidines KW - Reticulitermes clavipes KW - venom KW - Plant Composition (FF040) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of magainins and cecropins on the sporogonic development of malaria parasites in mosquitoes. AU - Gwadz, R. W. AU - Kaslow, D. AU - Lee, J. Y. AU - Maloy, W. L. AU - Zasloff, M. AU - Miller, L. H. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1989/// VL - 57 IS - 9 SP - 2628 EP - 2633 SN - 0019-9567 AD - Gwadz, R. W.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900598634. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Agricultural Biotechnology N2 - Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from saturniid moths (Hyalophora cecropia). In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes (Anopheles gambiae, A. dirus and/or A. freeborni) previously infected with a variety of Plasmodium species (P. cynomolgi, P. falciparum and/or P. knowlesi), both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocytes; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes for magainins, cecropins or similarly acting parasiticidal peptides into the mosquito genome.<new para>ADDITIONAL ABSTRACT:<new para>Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from giant silk moths. In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes previously infected with a variety of Plasmodium species, both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocysts; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes coding for magainins, cecropins, or similarly acting parasiticidal peptides into the mosquito genome.AS. KW - Antibacterial agents KW - Biotechnology KW - development KW - Gene expression KW - Human diseases KW - Immune system KW - immunity KW - Infections KW - inhibition KW - Intermediate hosts KW - parasites KW - Transmission blocking immunity KW - vectors KW - Anopheles KW - Anopheles dirus KW - Anopheles freeborni KW - Anopheles gambiae KW - Apicomplexa KW - Culicidae KW - Diptera KW - Insects KW - Plasmodium KW - Plasmodium cynomolgi KW - Plasmodium falciparum KW - Plasmodium knowlesi KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Protozoa KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Cecropins KW - Magainins KW - mosquitoes KW - secondary hosts KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) KW - Pesticides and Drugs (General) (HH400) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900598634&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting. AU - Melby, P. C. AU - Sacks, D. L. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1989/// VL - 57 IS - 10 SP - 2971 EP - 2976 SN - 0019-9567 AD - Melby, P. C.: D. L. Sacks, Laboratory of Parasitic Diseases, Section of Immmunology and Cell Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900860295. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology N2 - The generation of human T-lymphocyte clones derived from 2 patients with healed leishmaniasis (presumed to be Leishmania braziliensis and L. donovani) is described. By use of the one- and two-dimensional cellular immunoblotting techniques, the parasite antigens recognized by these clones were identified. These are thought to be the first leishmanial antigens identified to which CD4+, gamma interferon-producing T cells from immune individuals have been shown to respond. KW - antigens KW - Human diseases KW - parasites KW - T lymphocytes KW - Leishmania braziliensis KW - Leishmania donovani KW - protozoa KW - Sarcomastigophora KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - immunogens KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900860295&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of regulatory elements of the equine infectious anemia virus and caprine arthritis-encephalitis virus long terminal repeats. AU - Sherman, L. AU - Yaniv, A. AU - Lichtman-Pleban, H. AU - Tronick, S. R. AU - Gazit, A. JO - Journal of Virology JF - Journal of Virology Y1 - 1989/// VL - 63 IS - 11 SP - 4925 EP - 4931 SN - 0022-538X AD - Sherman, L.: S.R. Tronick, Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19902200068. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Veterinary Science N2 - The equine infectious anaemia virus (EIAV) long terminal repeat (LTR) was examined for sequences that influence its promoter activity and ability to be trans-activated by the EIAV tat gene product. A series of LTR deletion mutants and recombinants between LTR and simian virus 40 (SV 40) regulatory sequences were used for these studies. It was possible to identify the EIAV promoter region and sequences within the U3 region were shown to significantly inhibit LTR-directed transcription. However, when placed in a heterologous context (SV40 promoter) these U3 sequences functioned as an enhancer. Trans-activation of the EIAV LTR was found to depend upon sequences downstream of the transcription initiation site and also within U3. Deletion mutagenesis experiments showed that the major downstream element was present in a 46-nucleotide stretch (+4 to +50). An SV40 promoter construct containing these sequences could be trans-activated in cells expressing the EIAV tat gene product. For comparative purposes the LTR of another animal lentivirus, caprine arthritis-encephalitis virus (CAEV) were also examined for positive and negative transcriptional regulatory elements and demonstrated the presence of an enhancer within its U3 sequence. There is evidence that trans-activation of the CAEV LTR requires U3 sequences. When the EIAV U3 region was replaced by the CAEV U3 sequence, the promoter activity of the EIAV LTR was markedly increased, but responsiveness tothe EIAV trans-activator could not be restored. KW - Biotechnology KW - cat diseases KW - DNA KW - Gene expression KW - horse diseases KW - Molecular biology KW - Nucleotides KW - Strain differences KW - viral diseases KW - Caprine arthritis encephalitis virus KW - cats KW - equine infectious anemia virus KW - horses KW - Lentivirus KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Equus KW - Equidae KW - Perissodactyla KW - deoxyribonucleic acid KW - Equine infectious anaemia virus KW - Lentivirinae KW - viral infections KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902200068&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect on fetal growth of protozoan and helminthic infection during pregnancy. AU - Villar, J. AU - Klebanoff, M. AU - Kestler, E. JO - Obstetrics and Gynecology (New York) JF - Obstetrics and Gynecology (New York) Y1 - 1989/// VL - 74 IS - 6 SP - 915 EP - 920 SN - 0029-7844 AD - Villar, J.: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Executive Plaza North, Room 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864989. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Helminthology; Protozoology N2 - A prospective study of 14 914 pregnant women was conducted in Guatemala City, Guatemala. Stool samples were obtained from the women before the first prenatal visit (mean gestational age 21.6 weeks) for the diagnosis of parasitic infections during pregnancy. 44% harboured at least one parasite, and 24% were infected with helminths. Ascaris lumbricoides was the most prevalent (14.5%). Infected mothers were less educated, had less adequate water and sanitary conditions, and had lower nutritional status than uninfected women. The incidence of intrauterine growth retardation (IUGR) increased with the number of parasite species detected (up to 2 or more species). High levels of infection were associated with an increased risk of IUGR for protozoa and helminths, except for Strongyloides stercoralis and Hymenolepis nana. Chronically malnourished women (of short stature) had significantly higher IUGR rates when infected with one or 2 or more species; parasitic infection did not affect IUGR in women taller than 1.47 m. It is concluded that up to 10% of the IUGR rates may be attributed to parasitic infections in malnourished women. KW - Females KW - fetal growth KW - helminths KW - Human diseases KW - Parasites KW - pathology KW - pregnancy KW - Central America KW - Guatemala KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - America KW - CACM KW - Central America KW - Developing Countries KW - Latin America KW - foetal growth KW - gestation KW - parasitic worms KW - prevalence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864989&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans. AU - Goldstein, D. S. AU - Stull, R. AU - Eisenhofer, G. AU - Gill, J. R., Jr. JO - Clinical Science JF - Clinical Science Y1 - 1989/// VL - 76 IS - 5 SP - 517 EP - 522 SN - 0143-5221 AD - Goldstein, D. S.: Building 10, Room 7N238, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901451245. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63-84-5, 51-61-6, 7440-23-5. Subject Subsets: Human Nutrition N2 - Daily excretion of dihydroxyphenylalanine (dopa) and dopamine (DA) was assessed in 10 normal adults on a constant diet during 1 week of normal sodium intake (109 mmol daily), 1 week of low Na intake (9 mmol daily) and 1 week of high Na intake (249 mmol daily). Urinary DA excretion exceeded urinary dopa excretion about 10-fold. The excretion of DA and dopa about doubled between the low- and high-salt diets. Plasma dopa was unchanged by dietary salt manipulation. Results indicate that dopa may function indirectly as a neurohormone in homeostatic regulation of Na balance. KW - Dopa KW - Dopamine KW - intake KW - sodium KW - urine KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dioxyphenylalanine KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451245&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lymphocyte subpopulations in bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction. AU - Lal, R. B. AU - Kumaraswami, V. AU - Krishnan, N. AU - Nutman, T. B. AU - Ottesen, E. A. JO - Clinical and Experimental Immunology JF - Clinical and Experimental Immunology Y1 - 1989/// VL - 77 IS - 1 SP - 77 EP - 82 SN - 0009-9104 AD - Lal, R. B.: E. Ottesen, Building 4, Room 126, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910866544. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - To examine the relationship between lymphocyte phenotypes and states of activation in patients with bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n=15), and on patients with either asymptomatic microfilaraemia (MF; n=12) or elephantiasis (CP; n=11). In contrast to findings by others in a population with brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found to be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 ± 8.6%) than in the MF (8.9 ± 2.6%) or NV (8.3 ± 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen-induced proliferation was seen. These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease. KW - bancroftian filariasis KW - filariids KW - helminths KW - Human diseases KW - immune response KW - immunology KW - parasites KW - Pathogenesis KW - T lymphocytes KW - Brugia malayi KW - Brugia timori KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Wuchereria KW - immunity reactions KW - immunological reactions KW - lymphocyte phenotypes KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910866544&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fluoridation then and now. AU - Corbin, S. B. T2 - American Journal of Public Health JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1989/// VL - 79 IS - 5 SP - 561 EP - 563 SN - 0090-0036 AD - Corbin, S. B.: Disease Prevention Policy Analyst, National Institutes of Health, National Institute of Dental Research, Westwood Building, Room 538, 5333 Westbard Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19911453833. Publication Type: Editorial. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - The positive contribution of fluoridated drinking water to community health is discussed. Studies beginning with the successful two-city trial in the USA in 1945 are highlighted. KW - Drinking water KW - fluoridation KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453833&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Is alcohol consumption related to breast cancer? Results from the Framingham Heart Study. AU - Schatzkin, A. AU - Carter, C. L. AU - Green, S. B. AU - Kreger, B. E. AU - Splansky, G. L. AU - Anderson, K. M. AU - Helsel, W. E. AU - Kannel, W. B. JO - Journal of National Cancer Institute JF - Journal of National Cancer Institute Y1 - 1989/// VL - 81 IS - 1 SP - 31 EP - 35 AD - Schatzkin, A.: Executive Plaza North, Rm. 211J, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901450991. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition N2 - A total of 2636 women 31 to 64 years old, in the Framingham Heart Study cohort in Massachusetts, USA, provided information on alcohol consumption at the second biennial examination. During a 32-year follow-up, breast cancer was diagnosed in 143 women. Alcohol intake was also assessed at 10 and 20 years of follow-up and every 2 years thereafter. In analyses using only baseline alcohol intake, the multiple risk factor-adjusted relative risk (RR) estimate of breast cancer for any drinking, compared with non-drinking, was 0.8 [95% confidence interval (CI) 0.5 to 1.1]. For 3 levels of alcohol intake (0.1 to 1.4, 1.5 to 4.9 and 5.0 g or more daily), the baseline analyses yielded RRs (compared with non-drinking) of 1.0 (CI 0.6 to 1.5), 0.7 (CI 0.4 to 1.1) and 0.6 (CI 0.4 to 1.0), respectively. In analyses incorporating repeated measures of alcohol, the comparable RRs were 0.9 (CI 0.6 to 1.2) for any drinking (compared with non-drinking) and 0.7 (CI 0.4 to 1.4), 1.1 (CI 0.7 to 1.8) and 0.8 (CI 0.5 to 1.2), respectively, for the 3 levels of intake (compared with non-drinking). Results indicate that alcohol consumption was not associated with an increased risk of breast cancer in this cohort. KW - alcohols KW - Carcinoma KW - mammary glands KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450991&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Myosin I heavy-chain genes of Acanthamoeba castellanii: cloning of a second gene and evidence for the existence of a third isoform. AU - Jung, G. AU - Schmidt, C. J. AU - Hammer, J. A., III JO - Gene JF - Gene Y1 - 1989/// VL - 82 IS - 2 SP - 269 EP - 280 SN - 0378-1119 AD - Jung, G.: J.A. Hammer, National Institutes of Health, National Heart, Lung and Blood Institute, Building 3, Room B1-22, Bethesda, MD 20892, USA. N1 - Accession Number: 19890859708. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - The complete sequence and structure of a myosin I heavy-chain gene (MIL) from A. castellanii was determined. This gene spans ~ 6 kb, is split by 17 introns, encodes a 1147-amino acid polypeptide, and is transcribed in log-phase cells. The positions of 6 of the introns are conserved relative to a vertebrate muscle myosin gene. Similar to the previously characterized MIB heavy-chain gene, the deduced MIL heavy-chain amino acid sequence revealed a 125 000 MW protein composed of a myosin globular head domain joined to a novel, ~ 50 000 MW C-terminal domain rich in glycine, proline and alanine residues. There were differences between MIL and MIB in the sequence organization of their unconventional C-terminal domains. It is concluded from this and other data that Acanthamoeba express at least 3 myosin I heavy-chain isoforms: MIL, MIA and MIB. Amoeba genomic DNA blots probed with a short, highly conserved sequence whose position is transposed between MIB and MIL indicated that the Acanthamoeba myosin I heavy-chain gene family may contain 6 genes. The myosin I sequences were compared with those of Drosophila NinaC and the bovine myosin I-like protein, and it was found that a portion of the unconventional C-terminal domains of the amoeba myosins I and the bovine protein appear to be related. KW - genes KW - Human diseases KW - molecular genetics KW - myosins KW - parasites KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting. AU - Melby, P. C. AU - Neva, F. A. AU - Sacks, D. L. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1989/// VL - 83 IS - 6 SP - 1868 EP - 1875 SN - 0021-9738 AD - Melby, P. C.: D. L. Sacks, Building 5, Room 112, National Institute of Health, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19890859153. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology N2 - The pattern of peripheral blood lymphocyte responses was determined in patients with active, healed, or subclinical Leishmania infection to fractionated leishmanial antigens using a T cell immunoblotting method in which nitrocellulose-bound leishmanial antigens, resolved by one or two dimensional electrophoresis, are incorporated into lymphocyte cultures. The proliferative and interferon-γ responses of cells from patients with healed mucosal or cutaneous leishmaniasis were remarkably heterogenous and occurred to as many as 50-70 distinct antigens. In contrast, responses from subjects with active, nonhealing, diffuse cutaneous leishmaniasis were either absent or present to only a small number of antigens. This indicates that control and resolution of leishmaniasis, and resistance to reinfection is associated with a T cell response to a large and diverse pool of parasite antigens. T cell immunoblotting appears to be an appropriate method for the identification of antigens involved in eliciting a T cell response in human leishmaniasis. KW - antigens KW - characterization KW - Human diseases KW - immunoblotting KW - parasites KW - T lymphocytes KW - Leishmania KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - immunogens KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859153&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. AU - Lowe, W. L., Jr. AU - Adamo, M. AU - Werner, H. AU - Roberts, C. T., Jr. AU - LeRoith, D. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1989/// VL - 84 IS - 2 SP - 619 EP - 626 SN - 0021-9738 AD - Lowe, W. L., Jr.: D. LeRoith, Building 10, Room 8S243, Diabetes Branch, NIDDK Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19891421824. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9038-70-4. Subject Subsets: Human Nutrition N2 - In rats which were deprived of food for 48 h total insulin-like growth factor I (IGF-I) mRNA values decreased by about 80% in lung and liver, about 60% in kidney and muscle, and only about 30 to 40% in stomach, brain and testes. In heart, IGF-I mRNA values did not change. The amounts of the different splicing variants of the primary IGF-I transcript, were essentially coordinately regulated within a given tissue. Specific [125I]IGF-I binding in lung, testes, stomach, kidney and heart was increased by food deprivation by about 30 to 100%, whereas in brain [125I]IGF-I binding did not change in response to deprivation. In tissues in which deprivation increased IGF-I receptor number, receptor mRNA values increased about 1.6- to 2.5-fold, whereas when IGF-I receptor number was unchanged in response to deprivation, receptor mRNA values did not change. KW - Somatomedin KW - starvation KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - insulin-like growth factor 1 KW - sulfation factor KW - sulphation factor KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891421824&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prospective study of the standard meal provocative test in Zollinger-Ellison syndrome. AU - Frucht, H. AU - Howard, J. M. AU - Stark, H. A. AU - McCarthy, D. M. AU - Maton, P. N. AU - Gardner, J. D. AU - Jensen, R. T. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1989/// VL - 87 SP - 528 EP - 536 SN - 0002-9343 AD - Frucht, H.: R.T. Jensen, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419990. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition N2 - The proposed usefulness of a standard meal-stimulated gastrin provocative test was studied in: distinguishing Zollinger-Ellison syndrome (ZES) from antral syndromes; localizing duodenal gastrinomas; or suggesting that patients with multiple endocrine neoplasia type I (MEN-I) may have an increased incidence of antral syndromes. A total of 74 consecutive patients with ZES were studied prospectively. The extent and location of gastrinomas, acid secretory studies and the presence or absence of MEN-I were noted and correlated with the results of the gastrin response to standard meal provocative testing. Of 43 patients with fasting serum gastrin concentrations less than 1000 pg/ml, only 19 had a less than 50% increase over the premeal value, which is reported to be the typical response in ZES, and 17 had a 50 to 99% increase; 7 had a 100% or greater increase, 4 a 150% or greater increase, and 2 a 200% or greater increase, which overlaps with values reported to be characteristic of 98, 92 and 46% of patients with antral syndromes. Results did not differ for patients with or without MEN-I, depend on the extent of the gastrinoma (duodenal versus pancreatic gastrinomas), the presence of previous gastric surgery or type of gastric surgery or for patients with fasting serum gastrin concentrations 1000 or more or for those with less than 1000 pg/ml. Studies of 4 patients before and after resection of the gastrinoma, who before surgery had a greater than 100% increase in gastrin secretion after the meal, showed that all patients had a less than 100% increase after surgery even though no gastric resection was done. KW - tests KW - Zollinger-Ellison syndrome KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419990&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Establishing an enteral product formulary. AU - Ford, D. B. AU - Bergerson, S. L. AU - Henderson, P. AU - Murphy, J. A. AU - Peter, J. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1989/// VL - 89 IS - 5 SP - 681 EP - 683 SN - 0002-8223 AD - Ford, D. B.: Nutrition Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921441014. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition N2 - At the Clinical Center, National Institutes of Health, Bethesda, MD, USA, the nutrition department created a formula management committee, which developed a system that aligned formula product selection with the enteral needs of the patients, provided an ongoing system of formula management, and provided extensive education to dietitians on product formulation. The formula system involved categories of products to be considered and criteria for product selection, identification of enteral needs of patients in the institution, review of current literature on formulation of all major enteral products, and taste evaluation of products to be used orally. Composition of the formula was then determined, and interdepartmental efforts for implementation were coordinated. The overall impact included a 37% reduction in variety of products stocked, the creation of an annual update system, and extensive dietetic education on product formulation and usage. The direct impact on patient care was the provision of formula specifically targeted to meet the enteral needs of patients at nutritional risk within the institution. KW - Enteral feeding KW - formulations KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921441014&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrient intake recommendations needed for the older American. AU - Andres, R. AU - Hallfrisch, J. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1989/// VL - 89 IS - 12 SP - 1739 EP - 1741 SN - 0002-8223 AD - Andres, R.: Gerontology Research Center, Metabolism Section, Laboratory of Clinical Physiology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. N1 - Accession Number: 19901451896. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition N2 - Dietary needs and habits of the elderly in the USA are discussed. Until recently little attention was paid to dietary needs of the elderly and what recommendations there were were largely based on extrapolations of studies made with young subjects, usually men. Recent studies indicate that requirements for several nutrients may be different for older and younger adults and for older men and older women. KW - nutrient requirements KW - Old age KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - dietary standards KW - food requirements KW - nutritional requirements KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451896&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of duck hepatitis B virus replication by 2′,3′-dideoxycytidine. A potent inhibitor of reverse transcriptase. AU - Kassianides, C. AU - Hoofnagle, J. H. AU - Miller, R. H. AU - Doo, E. AU - Ford, H. AU - Broder, S. AU - Mitsuya, H. JO - Gastroenterology JF - Gastroenterology Y1 - 1989/// VL - 97 IS - 5 SP - 1275 EP - 1280 SN - 0016-5085 AD - Kassianides, C.: Liver Diseases Section, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19902206630. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 7841-89-2. Subject Subsets: Veterinary Science; Veterinary Science; Poultry; Public Health N2 - The effect of the antiviral 2′,3′-dideoxycytidine (DDC) was assessed both in vitro and in vivo against chronic infections of duck hepatitis B virus (DHBV) in 18 Pekin ducks; to see whether it could inhibit reverse transcriptase in view of the fact that human HBV belong to the hepadnaviruses, which contain reverse transcriptase. Over 6 days 9 ducks were given 11 mg/m² of DDC i.v. every 6 hours, 2 ducks were given 1000 and 400 mg/m² of adenine arabinoside monophosphate (Ara-AMP) i.m. twice daily and 7 ducks received no treatment. Blood samples from the wing vein were analysed for serum DHBV deoxyribonucleic acid (DNA) polymerase activity using autoradiography, and samples from liver biopsies were examined by light microscopy. Plasma levels of DDC as determined by high performance liquid chromatography, had an estimated peak of 60 µM. Serum DHBV DNA and DNA polymerase activity decreased in every duck treated with DDC. The mean inhibition of DNA polymerase and duck hepatitis B virus DNA on the third day of treatment with DDC was 64% and 73%, respectively. Four ducks continued to show >50% inhibition 12 days after stopping treatment (inhibition of DNA polymerase on day 18 was 55%). The decrease in DNA levels was greater with Ara-AMP, there was a decrease of 71% with the low dose and 86% with the high dose. DHBV DNA which was measured in total cellular DNA extracted from liver biopsy specimens obtained before and on the last day of treatment with DDC showed an average inhibition of 96% in 3 ducks treated with DDC but showed no decrease in the remaining 5 ducks. It was concluded that DDC has potent antiviral activity against DHBV and potential use against chronic hepatitis B infection in humans.<new para>ADDITIONAL ABSTRACT:<new para>The authors report reduction in levels of duck hepatitis B DNA and polymerase activity of about two thirds in chronically infected ducks by the nucleoside analogue dideoxycytidine. These markers began to rise after cessation of therapy but not as rapidly as with other antiviral agents. [This drug is already in Phase II trials against HIV infection].D.W. FitzSimons KW - Antiviral agents KW - dideoxycytidine KW - Hepatitis B KW - poultry KW - treatment KW - Viral diseases KW - duck hepatitis virus KW - Ducks KW - Hepadnaviridae KW - Hepatitis B virus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Anatidae KW - Anseriformes KW - birds KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - DNA Reverse Transcribing Viruses KW - Hepadnaviridae KW - 2',3'-dideoxycytidine KW - dideoxycytidine inhibition KW - domesticated birds KW - viral infections KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902206630&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmania mexicana mexicana: quantitative analysis of the intracellular cycle. AU - Doyle, P. S. AU - Engel, J. C. AU - Gam, A. A. AU - Dvorak, J. A. JO - Parasitology JF - Parasitology Y1 - 1989/// VL - 99 IS - 3 SP - 311 EP - 316 SN - 0031-1820 AD - Doyle, P. S.: J.A. Dvorak, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA. N1 - Accession Number: 19900862739. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The complete intracellular cycle of the L. m. mexicana G. S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line using a culture system that allows the direct observation of individual intracellular parasites. A wide range of pre-replicative lag periods was found, implying that promastigotes may be in any phase of their DNA synthetic cycle when phagocytosed by the macrophage. Amastigotes replicated 2-3 times, after which the host cell died and liberated amastigotes that were taken up by other macrophages and continued to replicate. The mean amastigote population-doubling time in human macrophages (17.5 h) was not statistically different from promastigotes growing in axenic culture (16.4 h), but was nearly 2-fold less than amastigotes growing in mouse-derived IC-21 macrophages (33.7 h). These observations were markedly different to the results of the cover-glass culture assays of Leishmania-macrophage interactions, but it is concluded that the direct observation of amastigotes in the kinetic studies allowed an unambiguous description of the intracellular cycle of L. m. mexicana.<new para>ADDITIONAL ABSTRACT:<new para>The complete intracellular cycle of the Leishmania mexicana mexicana G.S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line utilizing a culture system that allows the direct observation of individual intracellular parasites. A wide range of pre-replicative lag periods exists, implying that promastigotes may be in any phase of their DNA synthetic cycle when phagocytosed by the macrophage. Amastigotes replicated 2-3 times, after which the host cell died and liberated amastigotes that were taken up by other macrophages and continued to replicate. The mean amastigote population-doubling time in human macrophages (17.5 h) was not statistically different from promastigotes growing in axenic culture (16.4 h), but was nearly 2-fold less than amastigotes growing in mouse-derived IC-21 macrophages (33.7 h). These observations are markedly different from cover-glass culture assays of Leishmania-macrophage interactions and provide an unambiguous description of the intracellular cycle of Leishmania mexicana mexicana.AS KW - development KW - Human diseases KW - in vitro KW - macrophages KW - parasites KW - Leishmania mexicana KW - protozoa KW - Sarcomastigophora KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania mexicana KW - intracellular cycle kinetics KW - Kinetoplastorida KW - Leishmania mexicana mexicana KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862739&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma membrane association of Acanthamoeba myosin I. AU - Miyata, H. AU - Bowers, B. AU - Korn, E. D. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1989/// VL - 109 SP - 1519 EP - 1528 SN - 0021-9525 AD - Miyata, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808686. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9064-37-3. KW - Actin KW - Human diseases KW - myosins KW - Plasma membranes KW - Proteins KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cell membrane KW - myosin KW - plasmalemma KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808686&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis pneumonia: from bench to clinic. AU - Masur, H. AU - Lane, H. C. AU - Kovacs, J. A. AU - Allegra, C. J. AU - Edman, J. C. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1989/// VL - 111 IS - 10 SP - 813 EP - 826 SN - 0003-4819 AD - Masur, H.: National Institutes of Health, Clinical Center, Critical Care Medicine, Room 10D48, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861748. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 93 ref. Subject Subsets: Protozoology N2 - This review article is an edited summary of a Clinical Staff Conference sponsored by the National Institutes of Health, US Department of Health and Human Sciences held in November 1988, at Bethesda, Maryland, USA. Recent advances in the knowledge of P. carinii pneumonia are discussed under the headings: immunologic bases for susceptibility; immunologic studies - epidemiologic and diagnostic implications; metabolic studies - therapeutic implications; the current approach to therapy and prophylaxis; molecular biology - future effects on taxonomy, diagnosis and therapy. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - clinical aspects KW - HIV infections KW - Human diseases KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - reviews KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - clinical picture KW - fungus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861748&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induced sputum to diagnose Pneumocystis carinii pneumonia in immunosuppressed pediatric patients. AU - Ognibene, F. P. AU - Gill, V. J. AU - Pizzo, P. A. AU - Kovacs, J. A. AU - Godwin, C. AU - Suffredini, A. F. AU - Shelhamer, J. H. AU - Parrillo, J. E. AU - Masur, H. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1989/// VL - 115 IS - 3 SP - 430 EP - 433 SN - 0022-3476 AD - Ognibene, F. P.: Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862575. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology N2 - Sputum induction with an ultrasonic nebulizer was used for the diagnosis of 20 episodes of clinical pneumonia that developed in 18 immunosuppressed children (mean age 7.3 years). Nine episodes of P. carinii pneumonia were documented in 8 children, 6 of whom were HIV positive. All 9 sputum specimens were positive by IFAT, and 8 were positive by toluidine blue staining. Five bronchoscopy procedures on 4 patients whose sputum was negative for P. carinii did not reveal P. carinii. Two patients with negative sputum showed clinical improvement after empirical treatment with trimethoprim sulfamethoxazole. Four sputum-negative patients who did not receive empirical treatment also improved clinically. All children tolerated ultrasonic nebulization; nausea and vomiting were the only side effects. It is concluded that sputum induction often provides a pulmonary specimen sufficient to diagnose P. carinii pneumonia. KW - children KW - clinical aspects KW - diagnosis KW - HIV infections KW - Human diseases KW - immunocompromised hosts KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - sputum induction KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - clinical picture KW - fungus KW - human immunodeficiency virus infections KW - Induced sputum KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862575&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A dietary and risk factor questionnaire and analysis system for personal computers. AU - Smucker, R. AU - Block, G. AU - Coyle, L. AU - Harvin, A. AU - Kessler, L. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1989/// VL - 129 IS - 2 SP - 445 EP - 449 SN - 0002-9262 AD - Smucker, R.: G. Block, Executive Plaza North, Room 313, Division of Cancer Prevention and Control, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901419506. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition N2 - The adaptation of a dietary and risk factor questionnaire and analysis system for use with IBM (or compatible) personal computers is reported. This system includes a flexible computer-assisted interview program which may be modified to suit investigator needs while preserving a standard output format. It also includes a nutrient analysis program for calculation of usual dietary intake. Each of these two major components has its own set of utilities and options, so that investigators may tailor the system to particular research areas. The nature and capabilities of the two main programs are described, as well as the development of the underlying system and the general flow of data in the system. KW - Diet study techniques KW - epidemiology KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419506&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma gondii: Mechanism of resistance to complement-mediated killing. AU - Fuhrman, S. A. AU - Joiner, K. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1989/// VL - 142 IS - 3 SP - 940 EP - 947 SN - 0022-1767 AD - Fuhrman, S. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873350. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9007-36-7. Subject Subsets: Protozoology N2 - Tachyzoites of T. gondii are resistant to lysis in non-immune human serum. An examination of the mechanism of this serum resistance in RH and P strain organisms, which differ markedly in virulence, but are equally resistant to serum killing, is reported. Rapid, but limited, activation of the alternative complement pathway occurred in non-immune human serum, with deposition of equivalent amounts of C3 on the 2 strains. C3 bound covalently to parasite acceptor molecules via an ester linkage. The predominant form of C3 was iC3b which cannot participate in formation of a lytic C5b-9 complex. Multiple membrane constituents of the tachyzoite of T. gondii may serve as acceptors for the limited amount of C3 deposited during incubation in non-immune serum. When tachyzoites were pre-sensitized with the lytic anti-p30 MAb 7B8, new amide-linked C3-acceptor complexes formed. Nearly equivalent C3 binding but a 3-fold enhancement of 125I-C9 binding occurred when MAb 7B8 pre-sensitized tachyzoites were compared to native organisms. These results indicate that tachyzoites of T. gondii are serum resistant because of failure to activate C efficiently. Pre-sensitization with a lytic MAb alters the site of complement deposition and augments C5b-9 formation. KW - complement KW - Human diseases KW - immune response KW - in vitro KW - parasites KW - tachyzoites KW - Apicomplexa KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873350&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. AU - Kumar, S. AU - Good, M. F. AU - Dontfraid, F. AU - Vinetz, J. M. AU - Miller, L. H. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1989/// VL - 143 IS - 6 SP - 2017 EP - 2023 SN - 0022-1767 AD - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864337. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology N2 - Pooled serum from BALB/c mice immunized against P. vinckei transferred limited protection to BALB/c mice and no protection to athymic nu/nu mice. In vivo depletion of CD4+ T cells in immune mice abrogated their immunity but this could be reversed through reconstitution of CD4-depleted mice with fractionated B-, CD8-, CD4+ immune spleen cells; however adoptive transfer of fractionated CD4+ T cells from immune spleen to naive BALB/c or histocompatible BALB/c nude mice did not render the recipients immune. In vivo depletion of CD8+ T cells did not influence parasitaemia in non-immune or immune mice. Splenectomy of immune mice completely reversed their immunity. Repletion of splenectomized mice with their own spleen cells did not reconstitute their immunity. The results suggest that some feature of the malaria-modified spleen acts in concert with the effector/inducer function of CD4+ T cells to provide protection against P. vinckei and that a malaria vaccine may require a combination of Plasmodium antigen to induce immune CD4+ T cells and an adjuvant to alter the spleen. KW - Disease models KW - immunity KW - Laboratory animals KW - parasites KW - spleen KW - Apicomplexa KW - mice KW - Plasmodium vinckei KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - CD4+ T lymphocytes KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864337&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. AU - James, S. L. AU - Glaven, J. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1989/// VL - 143 IS - 12 SP - 4208 EP - 4212 SN - 0022-1767 AD - James, S. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19910868018. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Helminthology N2 - Lymphokine (LK)-activated macrophages are cytotoxic for multicellular larvae of S. mansoni. Macrophage-mediated larval killing was found to be arginine dependent, as indicated by inhibition in the presence of exogenous arginase or the competitive inhibitor NG-monomethyl-L-arginine. Culture supernatant fluids from the larvicidal LK-activated macrophages contained nitrite, a product of activated macrophages derived by oxidation of arginine and implicated in the antitumour and antimicrobial effector function of these cells. Nitrite was not detectable in supernatant fluids obtained from nonactivated macrophages or from macrophages stimulated with LK in the presence of arginase or NG-monomethyl-L-arginine. Addition of excess iron or the reductant sodium dithionite to LK-activated macrophage cultures also inhibited larval killing in vitro, under conditions that have been shown by others to stabilize the activity of iron-containing enzymes involved in respiration. Nitrite production was not decreased under these conditions. These observations are consistent with the hypothesis that macrophage-mediated schistosomulum killing is caused, at least in part, by a mechanism proposed for tumour cytotoxicity, whereby production of reactive nitrogen intermediates triggers iron loss from critical target cell enzymes leading to lethal metabolic inhibition. Schistosomula were shown to be killed by inhibitors of mitochondrial respiration. KW - cytotoxicity KW - Developmental stages KW - helminths KW - Human diseases KW - Lymphokines KW - macrophages KW - parasites KW - schistosomula KW - Digenea KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - growth phase KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910868018&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The place of HDL in cholesterol management. A perspective from the National Cholesterol Education Program. AU - Grundy, S. M. AU - Goodman, D. S. AU - Rifkind, B. M. AU - Cleeman, J. I. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1989/// VL - 149 IS - 3 SP - 505 EP - 510 SN - 0003-9926 AD - Grundy, S. M.: J.I. Cleeman, National Cholesterol Education Program, Office of Prevention, Education, and Control, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901417538. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The guidelines developed by the Adult Treatment Panel of the USA National Cholesterol Education Program identified low-density lipoprotein (LDL) as the main atherogenic lipoprotein and high values of LDL cholesterol as the primary target for treatment to lower cholesterol. Low values of high-density lipoprotein (HDL) cholesterol were recognized as a risk factor for coronary heart disease. This report re-examines in depth the recommendations of the Adult Treatment Panel on HDL cholesterol. Questions are discussed. Should HDL cholesterol values be estimated in all adults, as recommended for total cholesterol and should patients found to have a low serum LDL cholesterol (less than 35 mg/100 ml or less than 0.91 mmol/litre) start medical treatment to increase the value? The guidelines of the Adult Treatment Panel are reaffirmed as appropriate from the current perspective. These guidelines recommend that HDL cholesterol values be estimated in patients deemed to be at high risk for coronary heart disease and suggest that HDL estimation is optimum for persons with borderline-high total values. The guidelines of the Adult Treatment Panel recommended that low HDL cholesterol values be raised mainly by hygienic means (i.e., smoking cessation, weight loss, aerobic exercise). When drug treatment is required for high LDL cholesterol values in the presence of low HDL values, cholesterol-lowering drugs that concomitantly increase HDL should be given first priority. KW - cholesterol KW - heart diseases KW - High density lipoprotein KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - coronary diseases KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417538&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Is coffee consumption a contributor to cardiovascular disease? Insights from the Framingham Study. AU - Wilson, P. W. F. AU - Garrison, R. J. AU - Kannel, W. B. AU - McGee, D. L. AU - Castelli, W. P. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1989/// VL - 149 IS - 5 SP - 1169 EP - 1172 SN - 0003-9926 AD - Wilson, P. W. F.: Framingham Study, National Heart, Lung, and Blood Institute, 118 Lincoln St, Framingham, MA 01701, USA. N1 - Accession Number: 19901417821. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - Reported coffee consumption during 1954 to 1958 and 1971 to 1973 was used to test for association with cardiovascular disease (CVD) incidence and lipid values in the Framingham (Massachusetts, USA) Study. Multivariate analysis was employed, regressing CVD on age, systolic pressure, cigarette use, body mass index, total cholesterol and coffee intake. In pooled analyses (2648 men with 549 CVD cases and 3566 women with 462 CVD cases) coffee intake was not associated with CVD incidence in smokers or non-smokers, irrespective of sex. Similarly, multivariate analyses for persons with existing CVD showed no association between coffee intake and subsequent CVD. In men significant negative associations between coffee and total cholesterol, and very-low-density lipoprotein cholesterol were seen, whereas in women positive associations with low-density lipoprotein cholesterol were observed. Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking. KW - cardiovascular diseases KW - Coffee KW - Massachusetts KW - USA KW - Coffea KW - Man KW - Rubiaceae KW - Rubiales KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417821&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates. AU - Kovacs, J. A. AU - Halpern, J. L. AU - Lundgren, B. AU - Swan, J. C. AU - Parrillo, J. E. AU - Masur, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1989/// VL - 159 IS - 1 SP - 60 EP - 70 SN - 0022-1899 AD - Kovacs, J. A.: Critical Care Medicine Department, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900860528. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology N2 - Monoclonal antibodies to rat and human P. carinii were developed, and their specificity was demonstrated by immunofluorescence and immunoblot studies. Only one of 5 monoclonal antibodies to rat P. carinii reacted with human P. carinii, and none of 4 monoclonal antibodies to human P. carinii reacted with rat P. carinii. Two antibodies to human P. carinii reacted by immunofluorescence with only one human P. carinii isolate; the other 2 reacted with all 16 isolates. Immunoblot studies identified major antigens of rat P. carinii with MWs of 40 000-100 000 and of human P. carinii with MWs of 22 000-95 000. These studies provide evidence of significant antigenic differences between rat and human P. carinii and are consistent with the suggestion that individual isolates of human P. carinii are also antigenically different. KW - antigens KW - Human diseases KW - monoclonal antibodies KW - Opportunistic infections KW - parasites KW - strain differences KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - antigenicity KW - fungus KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900860528&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents. AU - Kovacs, J. A. AU - Allegra, C. J. AU - Beaver, J. AU - Boarman, D. AU - Lewis, M. AU - Parrillo, J. E. AU - Chabner, B. AU - Masur, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1989/// VL - 160 IS - 2 SP - 312 EP - 320 SN - 0022-1899 AD - Kovacs, J. A.: Critical Care Medicine Department, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900867791. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 59-30-3. Subject Subsets: Protozoology N2 - Drug therapy studies imply that P. carinii and T. gondii possess the enzymes necessary for de novo folate synthesis. To verify this, incorporation of [³H]paraaminobenzoic acid ([³H]PABA) into reduced folates of P. carinii and T. gondii was investigated. Both parasites synthesized tritiated reduced folates. In P. carinii, 10-formyltetrahydrofolate and tetrahydrofolate, and in T. gondii, 5-formyltetrahydrofolate were the major synthesized folates. P. carinii remained metabolically active in vitro for only a few days. Because current systems for screening anti-Pneumocystis agents are cumbersome, the utility of this assay system for screening therapeutic agents was investigated. Sulfonamides and pentamidine efficiently inhibited de novo folate synthesis in P. carinii. Inhibitors of dihydrofolate reductase such as trimethoprim and trimetrexate were poor inhibitors for P. carinii but efficient inhibitors for T. gondii. This study demonstrates the first unambiguous evidence of metabolic activity in P. carinii, and provides a potential assay for efficiently screening anti-Pneumocystis drugs in vitro. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiinfective agents KW - antiprotozoal agents KW - Biochemistry KW - drugs KW - folic acid KW - Human diseases KW - Inhibitors KW - Metabolism KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - screening KW - synthesis KW - Techniques KW - testing KW - Apicomplexa KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - AIDS KW - antimicrobials KW - folacin KW - folate KW - folates KW - fungus KW - medicines KW - pharmaceuticals KW - screening tests KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Pesticides and Drugs (General) (HH400) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900867791&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prophylaxis of Pneumocystis carinii pneumonia: an update. AU - Kovacs, J. A. AU - Masur, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1989/// VL - 160 IS - 5 SP - 882 EP - 886 SN - 0022-1899 AD - Kovacs, J. A.: Bldg.10, Room 10D48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910881486. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology N2 - The prophylaxis of P. carinii pneumonia is discussed under the following headings: who should receive prophylaxis?; does treatment with zidovudine eliminate the need for specific antipneumocystis prophylaxis?; is prophylaxis effective in HIV-infected patients?; what are the risks of prophylaxis?; how should P. carinii prophylaxis be managed in HIV-infected patients? KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiprotozoal agents KW - HIV infections KW - Human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - prophylaxis KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - discussion KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910881486&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A specific and sensitive assay for the Lyme disease spirochete Borrelia burgdorferi using the polymerase chain reaction. AU - Rosa, P. A. AU - Schwan, T. G. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1989/// VL - 160 IS - 6 SP - 1018 EP - 1029 SN - 0022-1899 AD - Rosa, P. A.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19900501393. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - A highly specific and sensitive assay for B. burgdorferi, the causative agent of Lyme disease, was developed using the polymerase chain reaction (PCR). The target DNA sequence was of chromosomal origin and conserved, by hybridization analyses, among all strains of B. burgdorferi tested but was not present in the most closely related member of the genus, B. hermsii. The PCR assay developed from this sequence reacted with 17 of 18 strains of B. burgdorferi but not with any other Borrelia species tested. The assay was sensitive to fewer than 5 copies of the B. burgdorferi genome, even in the presence of a 106-fold excess of eukaryotic DNA. This assay should greatly facilitate the accurate diagnosis of Lyme disease and provide a means with which to investigate the pathogenesis, transmission and basic biology of B. burgdorferi. KW - assays KW - Biochemical techniques KW - detection KW - Diagnosis KW - Diagnostic techniques KW - DNA KW - Lyme disease KW - polymerase chain reaction KW - Tickborne diseases KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - deoxyribonucleic acid KW - lyme borreliosis KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900501393&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Impaired production of nerve growth factor in the submandibular gland of diabetic mice. AU - Kasayama, S. AU - Oka, T. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1989/// VL - 257 IS - 3,I SP - E400 EP - E404 SN - 0002-9513 AD - Kasayama, S.: T. Oka, Building 8, Room 304, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418704. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - The production of nerve growth factor (NGF) in submandibular glands was examined in 2 kinds of diabetic mice. In genetically diabetic (C57BL/KsJ db/db) mice, which show marked insulin resistance and hyperglycaemia, the concentration of NGF in the submandibular gland was less than one-tenth that of the non-diabetic controls. In streptozotocin-induced diabetic C57BL/KsJ mice, which show pancreatic insulitis leading to insulin deficiency and hyperglycaemia, the glandular NGF concentration fell in a time-dependent manner to 26% of control value at 5 weeks after the streptozotocin injection. Insulin given daily to the streptozotocin-induced diabetic mice restored the NGF concentration to almost the control value. The molecular size of NGF (13 kdalton) in the glandular extracts of the genetically diabetic (db/db) mice in Western blots was indistinguishable from that of the control mice, but its amount was reduced in the glands of the diabetic (db/db) mice. Although plasma NGF concentrations were normally below the sensitivity of the assay (less than 0.80 ng/ml) in control and diabetic (db/db) mice, administration of cycloytidine, which stimulates NGF release from the submandibular gland into the blood circulation, increased plasma NGF to 5.95 ng/ml in controls, but did not do so in the diabetic (db/db) mice. KW - Diabetes KW - growth KW - neurons KW - polypeptides KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - nerve cells KW - neurones KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418704&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human selenite metabolism: a kinetic model. AU - Patterson, B. H. AU - Levander, O. A. AU - Helzlsouer, K. AU - McAdam, P. A. AU - Lewis, S. A. AU - Taylor, P. R. AU - Veillon, C. AU - Zech, L. A. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1989/// VL - 257 IS - 3,II SP - R556 EP - R567 SN - 0002-9513 AD - Patterson, B. H.: Executive Plaza North, Room 344, Biometry Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19901418871. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - A model was developed to describe the kinetics of sodium selenite metabolism, based on plasma, urine and faecal samples obtained from 3 men and 3 women during 4 weeks after a single oral dose of 200 μg of enriched stable isotope tracer 74Se. The model describes absorption, distributed along the gastrointestinal tract and enterohepatic recirculation. The model includes 4 kinetically distinct plasma components, a subsystem consisting of the liver and pancreas, and a slowly turning-over tissue pool. For the 6 subjects, the ranges of mean residence times for the 4 plasma components were, respectively, 0.2 to 1.1, 3 to 8, 9 to 42 and 200 to 285 h; for the hepatopancreatic subsystem 4 to 41 days; and for the tissue pool 115 to 285 days. About 84% of the dose was absorbed and after 12 days about 65% remained in the body. The model predicts that after 90 days about 35% of this Se would be retained, primarily in the tissues. Separating Se metabolism into several distinct kinetic components is a first step in identifying the efficacious, nutritious and toxic forms of the element. KW - metabolism KW - Selenium KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418871&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The dietary fat-breast cancer hypothesis is alive. AU - Schatzkin, A. AU - Greenwald, P. AU - Byar, D. P. AU - Clifford, C. K. JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1989/// VL - 261 IS - 22 SP - 3284 EP - 3287 AD - Schatzkin, A.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA. N1 - Accession Number: 19891416908. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - Data from animal experiments and human correlation studies strongly support the dietary fat/breast cancer hypothesis and it is suggested that a causal relation between dietary fat and breast malignancy is biologically plausible. Negative findings from recent analytical epidemiological studies of dietary fat and breast cancer indicated that the hypothesis is no longer viable but it is argued that only limited conclusions should be drawn from epidemiological studies to date because of the narrow range of dietary fat intake among subjects and the substantial measurement error in dietary assessment. It is proposed that intensive efforts at designing better studies of the hypothesis are needed, including laboratory investigations in man that examine possible mechanisms for the effects of fat; large, prospective epidemiological studies; and randomized, controlled diet trials. KW - Carcinoma KW - fats KW - mammary glands KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891416908&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification and characterization of a third isoform of myosin I from Acanthamoeba castellanii. AU - Lynch, T. J. AU - Brzeska, H. AU - Miyata, H. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1989/// VL - 264 IS - 32 SP - 19333 EP - 19339 SN - 0021-9258 AD - Lynch, T. J.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861070. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Protozoology N2 - A third isoform of myosin I was isolated from A. castellanii and designated myosin IC. Peptide maps and immunoassays indicated that myosin IC is not a modified form of myosin IA, IB, or II. However, myosin IC has most of the distinctive properties of a myosin I. It is a globular protein of native MW ~ 162 000, apparently composed of a single 130 000 MW heavy chain and a pair of 14 000 MW light chains. It is soluble in MgATP at low ionic strength, conditions favouring filament assembly by myosin II. Myosin IC has high Ca2+- and (K+,EDTA)-ATPase activities. Its low Mg2+ -ATPase activity is stimulated to a maximum rate of 20/s by the addition of F-actin if its heavy chain has been phosphorylated by myosin I heavy chain kinase. The dependence of the Mg2+-ATPase activity of myosin IC on F-actin concentration is triphasic, and, at fixed concentrations of F-actin, this activity increases cooperatively as the concentration of myosin IC is increased. Myosin IC is capable of cross-linking F-actin, which, together with the kinetics of its actin-activated Mg2+-ATPase activity, suggests that it, like myosins IA and IB, possesses 2 independent actin-binding domains. KW - biochemistry KW - Human diseases KW - myosins KW - parasites KW - proteins KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861070&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The localization and sequence of the phosphorylation sites of Acanthamoeba myosins I. An improved method for locating the phosphorylated amino acid. AU - Brzeska, H. AU - Lynch, T. J. AU - Martin, B. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1989/// VL - 264 IS - 32 SP - 19340 EP - 19348 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900861071. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activities of Acanthamoeba myosins IA, IB, and IC are expressed only when a single site in their heavy chains is phosphorylated by a myosin I heavy chain-specific kinase. It is shown that phosphorylation occurs at Ser-315 in the myosin IB heavy chain, Ser-311 in myosin IC, and a threonine residue at a corresponding position in myosin IA (whose amino acid sequence is as yet unknown). The most obvious feature common to the 3 substrates is a basic amino acid 2 or 3 residues before the site of phosphorylation. The phosphorylation site is located between the ATP- and actin-binding sites, which corresponds to the middle of the 50 000 MW domain of skeletal muscle myosin subfragment 1. The sequence similarity between the region surrounding the phosphorylation site of myosin I and subfragment 1 is much lower than the average sequence similarity between myosin I and subfragment 1. This is consistent with the hypothesis that the conformation of this region of myosin I differs from that of the corresponding region in skeletal muscle myosin and that phosphorylation converts the conformation of the actomyosin I complex into a conformation comparable to that present in actosubfragment 1 without phosphorylation. The protein sequences obtained suggest that the myosin I genes previously identified as myosin IB and IL (myosin-like) heavy chains actually are the myosin IC and IB heavy chains, respectively. A modification of the method for monitoring the appearance of 32Pi during sequencing of 32P-labelled peptides that results in almost complete recovery of the radioactivity, thus allowing unequivocal assignment of the position of the phosphorylated residue, is described. KW - biochemistry KW - Human diseases KW - myosins KW - parasites KW - proteins KW - Acanthamoeba KW - protozoa KW - Sarcomastigophora KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - phosphorylation sites KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861071&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The modification of diet in renal disease study. AU - Klahr, S. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1989/// VL - 320 IS - 13 SP - 864 EP - 866 SN - 0028-4793 AD - Klahr, S.: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19901420014. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - Progress is reported on the Modification of Diet in Renal Disease study which is a multicentre cooperative study set up in the USA by the recommendations of the National Institute of Diabetes and Digestive and Kidney Diseases to define the influence of the dietary restriction of protein and phosphorus on the progression of chronic renal disease. KW - diet treatment KW - Kidney diseases KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diet prescription KW - kidney disorders KW - nephropathy KW - renal diseases KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901420014&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Developmental regulation of stage-specific ribosome populations in Plasmodium. AU - Waters, A. P. AU - Syin, C. AU - McCutchan, T. F. JO - Nature (London) JF - Nature (London) Y1 - 1989/// VL - 342 IS - 6248 SP - 438 EP - 440 SN - 0028-0836 AD - Waters, A. P.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, Building 4, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900865069. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Protozoology N2 - The switch from the A gene (that yields transcripts predominant in the asexual blood stage) to the C gene (mainly transcribed in the sporozoite developing in the mosquito) was studied in P. falciparum. The switch from A to C gene expression involved the control of rRNA processing, allowing accumulation of precursor C-gene transcripts in gametocytes. These precursor molecules are processed to mature size in the zygote and the early ookinete, where both transcription and processing of the C-gene rRNA seem to be accelerated. As the C-gene precursor rRNA appears, a defined and limited pattern of breakdown of the dominant A-gene RNA occurs, in which conserved, functionally active sequences involved in the termination of translation and elongation are targeted. By the late oocyst stage, the A-gene transcripts are virtually replaced by mature C-gene transcripts. KW - development KW - Human diseases KW - molecular genetics KW - parasites KW - ribosomes KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865069&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Strategies for malaria control: realities, magic and science. AU - Miller, L. H. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1989/// VL - 569 SP - 118 EP - 126 SN - 0077-8923 AD - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900866382. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Methods for malaria eradication and control are discussed under the headings: research on the Anopheles vector; chemotherapy research, research towards malaria vaccines. The interactions between discoveries in the laboratory, and their impact in the field, are emphasized. KW - control KW - disease vectors KW - Human diseases KW - Intermediate hosts KW - Malaria KW - Mosquito-borne diseases KW - parasites KW - Vectors KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - Insects KW - man KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - discussion KW - mosquitoes KW - secondary hosts KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900866382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An overview of the modification of diet in renal disease study. AU - Kusek, J. W. AU - Caggiula, A. W. AU - Williams, G. W. AU - Klahr, S. JO - Contributions to Nephrology JF - Contributions to Nephrology Y1 - 1989/// IS - 81 SP - 50 EP - 60 SN - 0302-5144 AD - Kusek, J. W.: Division of Kidney, Urologic and Hematologic Diseases, National Institutes of Health, Room 621, Westwood Building, 5333 Westbard Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19921439805. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition N2 - To test the effects of intervention(s) on the rate of progression of chronic renal disease, in a controlled clinical trial, the National Institutes of Health in USA, in collaboration with the Health Care Financing Administration, initiated the Modification of Diet in Renal Disease (MDRD) Study. The study is being carried out in four phases: protocol development (phase 1); pilot study (phase 2); full-scale study (phase 3), and data analysis and dissemination of results (phase 4). The purpose and design of the pilot investigation is briefly reviewed and an overview of the full-scale study is presented. KW - diet studies KW - Renal failure KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - kidney failure KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921439805&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structural features of Borrelia burgdorferi - the Lyme disease spirochete: silver staining for nucleic acids. AU - Garon, C. F. AU - Dorward, D. W. AU - Corwin, M. D. JO - Scanning Microscopy JF - Scanning Microscopy Y1 - 1989/// SP - 109 EP - 115 SN - 0891-7035 AD - Garon, C. F.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19910503520. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi was grown in a modified Kelly medium and characterized by transmission and scanning electron microscopy. Using silver staining procedures which preferentially bind to nuclear components of eukaryotic cells, signal could be detected by back-scattered electron imaging throughout the length of the spirochaete. Interestingly, however, the highest levels of back-scattered signal were observed in naturally elaborated membrane blebs that were attached to cell surfaces and free in the medium. These membranes vesicles could be enriched by filtration through nitrocellulose or Anopore membranes and by differential centrifugation. The possibility of contaminating cellular DNA coating the membrane vesicles was ruled out by exhaustive digestion with pancreatic DNAase I. Intact DNA was demonstrated both by lysing blebs directly on the surface of microscope grids and by extracting molecules from purified bleb preparation with detergents and solvents. Both linear and circular DNA molecules could be identified in purified membrane blebs. A simple, one-step, alternative silver staining procedure is described which appears to effectively label the protein-nucleic acid complexes contained in the membrane vesicles of B. burgdorferi. KW - DNA KW - electron microscopy KW - Scanning electron microscopy KW - staining KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - deoxyribonucleic acid KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910503520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fungal infections in granulocytopenic patients: current approaches to classification, diagnosis, and treatment. AU - Walsh, T. J. AU - Pizzo, P. A. A2 - Holmberg, K. A2 - Meyer, R.D. T2 - Diagnosis and therapy of systemic fungal infections. JO - Diagnosis and therapy of systemic fungal infections. JF - Diagnosis and therapy of systemic fungal infections. Y1 - 1989/// SP - 47 EP - 70 CY - New York; USA PB - Raven Press SN - 0881675539 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19901205605. Publication Type: Miscellaneous. Language: English. Number of References: 108 ref. Registry Number: 86386-73-4, 84625-61-6, 91161-71-6. Subject Subsets: Medical & Veterinary Mycology N2 - Aspects of host defence against fungi relevant to granulocytopenic patients are discussed and nosocomial infections of such patients are defined and classified. The clinical manifestations and treatment of mycoses in granulocytopenic patients, including those caused by Aspergillus, Pseudallescheria boydii, Fusarium, Candida, Trichosporon beigelii, plus phycomycoses and chromomycoses, are reviewed. The current status of antifungal agents, such as itraconazole, fluconazole and terbinafine, is also considered. KW - Antifungal agents KW - Fluconazole KW - infections KW - Itraconazole KW - Mycoses KW - phaeohyphomycosis KW - predisposition KW - Reviews KW - Terbinafine KW - therapy KW - zygomycosis KW - Aspergillus KW - Candida KW - Fusarium KW - Man KW - Pseudallescheria boydii KW - Trichosporon beigelii KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - chromomycosis KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - phycomycosis KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205605&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Essential obesity and the pathogenetic role of a low metabolic rate. AU - Bogardus, C. AU - Ravussin, E. A2 - Halsted, C.H. A2 - Rucker, R.B. T2 - Nutrition and the origins of disease. JO - Nutrition and the origins of disease. JF - Nutrition and the origins of disease. Y1 - 1989/// SP - 145 EP - 160 CY - San Diego, CA; USA PB - Academic Press, Inc. SN - 012319640X AD - Bogardus, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19901452138. Publication Type: Conference paper. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - Obesity is a familial and, to a significant extent, a genetic disorder caused by an excess of energy intake over expenditure. Accurate methods to assess the impact of disorders of feeding behaviour and appetite regulation on the imbalance in this energy equation are currently unavailable. However, studies of energy expenditure among the Pima Indians have shown that rates of energy expenditure vary more among individuals than can be accounted for by differences in body size, age or sex; rates of energy expenditure aggregate in families, independently of these covariates; low rate of energy expenditure is associated with an increased risk of weight gain. These data suggest that a low metabolic rate contributes to the familial aggregation of obesity. It seems evident that there is such a concept as "essential obesity". Research is urgently needed to develop new pharmacological agents to treat this disorder that is associated with significant morbidity and mortality. KW - energy exchange KW - metabolism KW - Obesity KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - Nutrition and the Origins of Disease KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452138&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Role of gastrointestinal hormones in adaptation. AU - Go, V. L. W. A2 - Halsted, C.H. A2 - Rucker, R.B. T2 - Nutrition and the origins of disease. JO - Nutrition and the origins of disease. JF - Nutrition and the origins of disease. Y1 - 1989/// SP - 321 EP - 331 CY - San Diego, CA; USA PB - Academic Press, Inc. SN - 012319640X AD - Go, V. L. W.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. N1 - Accession Number: 19901452154. Publication Type: Conference paper. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition N2 - The gastrointestinal neuroendocrine system plays an important role in the nutritional adaptation that takes place from the prenatal to the postnatal stages of development. Nutrients can regulate the secretion of gastrointestinal hormones and regulatory peptides, each of which has a unique regional distribution in both gut and neural tissues. Hormones and peptides including gastrin, secretin, cholecystokinin, gastric inhibitory polypeptide, motilin, human pancreatic polypeptide, enteroglucagon, neurotensin and the colon hormone peptide YY control the gut functions that are essential in converting food into absorbable nutrients and in the metabolic processes required for growth, development and survival. Carbohydrates, proteins and fats have different specificities and potencies in regulating secretion of different gut hormones and peptides, some of which exhibit trophic effects. The chronic release of a gut hormone or peptide in response to stimulation by a particular nutrient could result in adaptation in organ function but the cellular mechanisms involved in these processes remain to be elucidated. KW - Gastrointestinal hormones KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - gastric hormones KW - Nutrition and the Origins of Disease KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452154&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immunochemical characterization of the Leishmania donovani 3′-nucleotidase. AU - Pastakia, K. B. AU - Dwyer, D. M. A2 - D.T. Hart T2 - Leishmaniasis: The current status and new strategies for control. Proceedings of a NATO Advanced Study Institute on leishmaniasis: The first centenary (1885-1985), new strategies for control, Zakinthos, Greece, 20-27 September, 1987. Y1 - 1989/// CY - New York; USA PB - Plenum Press SN - 0306431467 AD - Pastakia, K. B.: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900863489. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 6 ref. Registry Number: 9033-33-4. Subject Subsets: Protozoology KW - biochemistry KW - enzymes KW - Human diseases KW - nucleotidase KW - parasites KW - promastigotes KW - Leishmania KW - Leishmania donovani KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - current status and new strategies for control KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863489&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Toxoplasmosis in patients with the acquired immunodeficiency syndrome. AU - Kovacs, J. A. T2 - Opportunistic infections in patients with the acquired immunodeficiency syndrome. Y1 - 1989/// CY - New York; USA PB - Marcel Dekker, Inc. SN - 0824780809 AD - Kovacs, J. A.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19900864986. Publication Type: Book chapter. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology N2 - A brief account of the life cycle of Toxoplasma gondii, the epidemiology and clinical manifestations of toxoplasmosis in the immunocompetent host, is followed by a review of its epidemiology and clinical manifestations in patients with AIDS, histopathology, laboratory evaluation, diagnosis, differential diagnosis and therapy. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Human diseases KW - Immunocompromised hosts KW - opportunistic infections KW - parasites KW - Apicomplexa KW - man KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - AIDS KW - general account KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864986&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The compromised host: AIDS and other diseases. AU - Masur, H. A2 - Walzer, P. D. A2 - Genta, R. M. T2 - Parasitic infections in the compromised host. Y1 - 1989/// CY - New York; USA PB - Marcel Dekker Inc. SN - 0834779436 AD - Masur, H.: Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19890859355. Publication Type: Book chapter. Language: English. Number of References: 76 ref. Subject Subsets: Helminthology; Protozoology N2 - Defence mechanisms in healthy humans, and immune disorders which compromise the host are considered. Protozoal and helminth infections in compromised patients and parasitic infections in AIDS patients are discussed. KW - helminths KW - Human diseases KW - immunocompromised hosts KW - Opportunistic infections KW - Parasites KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - discussed KW - parasitic infections in compromised hosts KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859355&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The host immune responses against parasitic helminth infection. AU - Nutman, T. B. A2 - Walzer, P. D. A2 - Genta, R. M. T2 - Parasitic infections in the compromised host. Y1 - 1989/// CY - New York; USA PB - Marcel Dekker Inc. AD - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19890859375. Publication Type: Book chapter. Language: English. Number of References: 130 ref. Subject Subsets: Helminthology N2 - The immune response of humans to helminth infection is considered under the headings: the parasites; genetic and environmental determinants of susceptibility to infection; evasion of the immune response by the parasites; immunological consequences of parasitic infection; unique factors of the immune responses to helminth parasites; effector mechanisms mediating host immunity to helminth parasites. KW - Helminths KW - Human diseases KW - immune response KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - general account KW - immunity reactions KW - immunological reactions KW - parasitic infections in compromised hosts KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859375&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Giardia lamblia. AU - Smith, P. D. A2 - Walzer, P. D. A2 - Genta, R. M. T2 - Parasitic infections in the compromised host. Y1 - 1989/// CY - New York; USA PB - Marcel Dekker Inc. SN - 0824779436 AD - Smith, P. D.: Laboratory of Immunology, NIDR, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19890859373. Publication Type: Book chapter. Language: English. Number of References: 248 ref. Subject Subsets: Protozoology N2 - G. lamblia infection in man is discussed under the headings: the organism (life cycle and epidemiology, growth and metabolism, antigenic components and virulence); the host (host defence mechanisms, pathogenesis, pathology); the disease (clinical features, diagnosis, treatment and prevention). KW - Human diseases KW - Opportunistic infections KW - parasites KW - Giardia duodenalis KW - man KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - general account KW - Giardia lamblia KW - Immunocomprised hosts KW - parasitic infections in compromised hosts KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859373&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasitic diseases. AU - Román, G. C. JO - Foundations of Neurology JF - Foundations of Neurology Y1 - 1990/// VL - 1 SP - 407 EP - 424 AD - Román, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874472. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Protozoology; Helminthology N2 - The recent advances in the treatment of cerebral malaria and neurocysticercosis are discussed. Topics covered include: clinical aspects; treatment; management of cerebral malaria; pathogenesis of cerebral malaria; prospective new therapies. KW - Anthelmintics KW - Antimalarials KW - Antiprotozoal agents KW - Developmental stages KW - drug therapy KW - helminths KW - Human diseases KW - Malaria KW - metacestodes KW - parasites KW - reviews KW - Apicomplexa KW - Cestoda KW - man KW - Plasmodium falciparum KW - protozoa KW - Taenia solium KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Platyhelminthes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - chemotherapy KW - growth phase KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874472&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunity to protozoa. AU - Miller, L. H. AU - Scott, P. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1990/// VL - 2 IS - 3 SP - 368 EP - 374 SN - 0952-7915 AD - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879335. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Protozoology N2 - Research on immunity to protozoa is reviewed under the headings of: malaria (pre-erythrocytic stage, asexual erythrocytic parasites, transmission-blocking immunity); Leishmania, Toxoplasma and Trypanosoma cruzi (T-cell subsets regulating protozoal immunity, role of cytokines in protozoal immunity, vaccine development). KW - Human diseases KW - immunity KW - parasites KW - reviews KW - Apicomplexa KW - Leishmania KW - man KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Sarcocystidae KW - Sarcomastigophora KW - Toxoplasma gondii KW - Trypanosoma cruzi KW - Trypanosomatidae KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - Eucoccidiorida KW - Toxoplasma KW - Sarcocystidae KW - Trypanosoma KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879335&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunity to helminths. AU - Pearce, E. J. AU - Sher, A. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1990/// VL - 2 IS - 3 SP - 375 EP - 379 SN - 0952-7915 AD - Pearce, E. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19920879336. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Helminthology N2 - As there have been dramatic advances in the understanding of the regulation of immune responses to helminths and in the development of effective, defined anti-helminth vaccines, this review concentrates on these 2 areas. KW - Helminths KW - Human diseases KW - immunity KW - immunization KW - parasites KW - reviews KW - Vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - immune sensitization KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879336&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activity of ivermectin in human parasitic infections other than onchocerciasis. AU - Ottesen, E. A. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1990/// VL - 3 IS - 6 SP - 834 EP - 837 SN - 0951-7375 AD - Ottesen, E. A.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874009. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 70288-86-7. Subject Subsets: Helminthology N2 - Clinical trials were carried out to determine the effectiveness of ivermectin against Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans, Mansonella ozzardi, Ascaris lumbricoides, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, and hookworms. The findings from these trials are summarized in this review. KW - Anthelmintics KW - Developmental stages KW - drug therapy KW - filariids KW - helminths KW - Hookworms KW - Human diseases KW - ivermectin KW - parasites KW - reviews KW - Ascaris lumbricoides KW - Brugia malayi KW - Enoplida KW - Enterobius vermicularis KW - Loa loa KW - man KW - Mansonella ozzardi KW - Mansonella perstans KW - Nematoda KW - Rhabditida KW - Strongyloides stercoralis KW - Trichuris trichiura KW - Wuchereria bancrofti KW - Ascaris KW - Ascarididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Brugia KW - Onchocercidae KW - Enterobius KW - Oxyuridae KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Mansonella KW - Strongyloides KW - Strongyloididae KW - Trichuris KW - Trichuridae KW - Trichinellida KW - Dorylaimia KW - Enoplea KW - Wuchereria KW - Enoplia KW - Adenophorea KW - African eyeworm KW - Ascaridida KW - chemotherapy KW - growth phase KW - nematodes KW - parasitic worms KW - pinworm KW - Secernentea KW - Spirurida KW - threadworm KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874009&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chinese food composition tables. AU - Ershow, A. G. AU - Wong-Chen, K. JO - Journal of Food Composition and Analysis JF - Journal of Food Composition and Analysis Y1 - 1990/// VL - 3 IS - 3/4 SP - 191 EP - 434 SN - 0889-1575 AD - Ershow, A. G.: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921442183. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Dairy Science N2 - The Chinese Food Composition Tables, representing 4 decades of effort by the Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, are presented in annotated translation with extensive supplementary material. Nutrient data for more than 600 foods include edible portion; proximate composition; energy, major mineral, trace element, vitamin and cholesterol content; and amino acid and fatty acid profile. Categories of foods represented include cereals; legumes; roots, tubers and stems; cultivated and wild vegetables; melons, squashes and gourds; fungi and algae; fruits; nuts; meats, poultry and eggs; dairy foods; fishes; molluscs, crustaceans and other invertebrates; reptiles and amphibians; alcoholic and non-alcoholic beverages; condiments; confections; and infant foods. Foods are identified by English common name and Latin scientific name, and are further described by habitat (for water-dwelling creatures), cooking and preparation method, location of sample collection or analysis, and other characteristics. Original Chinese descriptions of foods are presented in Pinyin transliteration. Textual material and footnotes from the original Chinese document are translated in full. Linking codes are provided for readers having access to the original Chinese version. Detailed three-language index (English-Latin-Chinese) allow ready identification and location of food items throughout all tables. Analytical methods used to obtain the data are described. Information is provided on the retention of vitamins in cooked foods, Chinese market units of weight and measure, and cooking and preparation techniques. A concluding discussion addresses the applicability and limitations of the tables, indicates statistical approaches to the data, and places this document in perspective with other food composition tables. KW - Cows KW - Food composition KW - Foods KW - China KW - cattle KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - People's Republic of China KW - Food Science and Food Products (Human) (QQ000) KW - Food Composition and Quality (QQ500) KW - Milk and Dairy Produce (QQ010) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442183&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrition and cancer prevention activities in state health agencies. AU - Heimendinger, J. AU - Foerster, S. AU - Kaufman, M. AU - Light, L. JO - Health Education Research JF - Health Education Research Y1 - 1990/// VL - 5 IS - 4 SP - 545 EP - 550 SN - 0268-1153 AD - Heimendinger, J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921449218. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - Opinions from key personnel about nutrition and cancer prevention activities in the USA are reported. The majority of respondents felt that the science base linking diet and cancer was sufficient to warrant public health action, especially public education and interagency collaboration though fewer viewed environmental change, such as collaborative efforts with supermarkets or efforts to mobilize whole communities as priorities. KW - health services KW - Neoplasms KW - nutrition KW - prevention KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Human Nutrition (General) (VV100) KW - Education, Extension, Information and Training (General) (CC000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921449218&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. AU - Knowler, W. C. AU - Pettitt, D. J. AU - Saad, M. F. AU - Bennett, P. H. JO - Diabetes/Metabolism Reviews JF - Diabetes/Metabolism Reviews Y1 - 1990/// VL - 6 IS - 1 SP - 1 EP - 27 SN - 0742-4221 AD - Knowler, W. C.: Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. N1 - Accession Number: 19921441489. Publication Type: Journal Article. Language: English. Number of References: 149 ref. Subject Subsets: Human Nutrition N2 - The Pima Indians of Arizona have the highest recorded prevalence and incidence of non-insulin-dependent diabetes of any geographically-defined population. In this review the prevalence, incidence, risk factors and pathogenesis of diabetes in the Pima Indians are discussed. The epidemiological evidence indicates that non-insulin-dependent diabetes results from interaction of genetic and environmental factors. The principal goal of epidemiological research in diabetes is prevention or postponement of the onset of the disease. Further expansion of the knowledge of genetics of the disease to allow identification of susceptible subjects has important implications for intervention strategies. These may be tested in populations known to be susceptible to the disease and therefore more likely to benefit. Based on the current knowledge of the epidemiology and risk factors for the disease, intervention approaches involving drugs, diet and exercise appear to have the potential to reduce the incidence of diabetes in subjects at high risk. KW - diabetes KW - Ethnic groups KW - reviews KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921441489&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of nitrogen oxides as effector molecules of parasite killing. AU - James, S. L. AU - Hibbs, J. B., Jr. JO - Parasitology Today JF - Parasitology Today Y1 - 1990/// VL - 6 IS - 9 SP - 303 EP - 305 AD - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872936. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology; Helminthology N2 - The novel mammalian biochemical pathways for the synthesis of inorganic nitrogen oxides that mediate antibody-independent killing of infectious agents (including extracellular helminths, extracellular fungi and intracellular protozoa) as well as of tumour cells are discussed. KW - helminths KW - Human diseases KW - immune response KW - nitrogen oxides KW - Parasites KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872936&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vector-spirochete relationships in louse-borne and tick-borne borrelioses with emphasis on Lyme disease. AU - Burgdorfer, W. AU - Hayes, S. F. JO - Advances in Disease Vector Research JF - Advances in Disease Vector Research Y1 - 1990/// VL - 6 SP - 127 EP - 150 CY - New York; USA PB - Springer-Verlag SN - 0387970800\3540970800 AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19910502000. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Salient findings on the development and transmission of Borrelia burgdorferi in and through its Ixodes vectors are compared and contrasted with these aspects of B. recurrentis, B. duttonii and B. theileri (among other borreliae) in their respective louse (Pediculus humanus) and tick (Ornithodoros moubata, Rhipicephalus spp., Boophilus spp.) vectors. After a brief historical introduction, a table summarizes the characteristics and geographical distribution of all arthropod-borne borreliae. Three sections then follow on the behaviour of louse-borne and tick-borne spirochaetes, of B. theileri, and of B. burgdorferi in their vectors, then a section on the relationship of B. burgdorferi to non-specific tick vectors (notably Dermacentor variabilis, Amblyomma americanum, and ticks of the jack rabbit Lepus californicus californicus) and other haematophagous arthropods (Chrysops callidus, Aedes spp.), and finally a section identified "B. burgdorferi: subject to a complex development cycle? ". In conclusion, the main points and areas for further research in this fast-moving subject are highlighted, including the apparent relative unimportance of transovarial transmission for B. burgdorferi, the likelihood that Haemaphysalis leporipalustris and I. dentatis play a role in maintaining B. burgdorferi in lagomorph populations, the possibility of mechanical transmission by Chrysops, Tabanus and mosquitoes, and certain complexities of spirochaete development in their arthropod and vertebrate hosts. KW - disease vectors KW - host parasite relationships KW - reviews KW - Tickborne diseases KW - vectors KW - Zoonoses KW - Acari KW - Anoplura KW - Arachnida KW - Argasidae KW - Borrelia KW - Borrelia burgdorferi KW - Borrelia duttonii KW - Borrelia recurrentis KW - Borrelia theileri KW - Culicidae KW - Diptera KW - Ixodes scapularis KW - Ixodidae KW - Lagomorpha KW - Leporidae KW - Mammals KW - Pediculus KW - Phthiraptera KW - Spirochaetaceae KW - Tabanidae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Phthiraptera KW - insects KW - Hexapoda KW - Metastigmata KW - Acari KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - Diptera KW - Ixodes KW - Ixodidae KW - mammals KW - vertebrates KW - Chordata KW - Lagomorpha KW - Pediculidae KW - Anoplura KW - bacterium KW - Ixodes dammini KW - Louse-borne diseases KW - mosquitoes KW - parasite host relationships KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910502000&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Strategies for cancer prevention through diet modification. AU - Greenwald, P. AU - Light, L. AU - McDonald, S. S. AU - Stern, H. R. JO - Medical Oncology and Tumor Pharmacotherapy JF - Medical Oncology and Tumor Pharmacotherapy Y1 - 1990/// VL - 7 IS - 2/3 SP - 199 EP - 200 AD - Greenwald, P.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Building 31, Room 10A52, Bethesda, MD 20892, USA. N1 - Accession Number: 19911431192. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition N2 - Strategies for cancer prevention through diet modification are described, with emphasis on the translation of basic scientific knowledge into effective applications that can result in increased public health benefits. The discussion addresses diet and chemoprevention-related cancer prevention research at the National Cancer Institute; the formulation of interim dietary guidelines; channels for delivering dietary guidance to the public to promote consumer diet modification; and the potential influence of biotechnology and the changing food supply on lowering cancer incidence. KW - Carcinogenesis KW - diets KW - prevention KW - Sweden KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - Nutrition and cancer KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431192&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi. AU - Simpson, W. J. AU - Garon, C. F. AU - Schwan, T. G. JO - Microbial Pathogenesis JF - Microbial Pathogenesis Y1 - 1990/// VL - 8 IS - 2 SP - 109 EP - 118 SN - 0882-4010 AD - Simpson, W. J.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19950800299. Publication Type: Journal Article. Language: English. Number of References: 11 ref. KW - human diseases KW - Lyme disease KW - plasmids KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800299&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Blood magnesium parameters do not differ with age. AU - Yang, X. Y. AU - Hosseini, J. M. AU - Ruddel, M. E. AU - Elin, R. J. JO - Journal of the American College of Nutrition JF - Journal of the American College of Nutrition Y1 - 1990/// VL - 9 IS - 4 SP - 308 EP - 313 SN - 0731-5724 AD - Yang, X. Y.: Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429727. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7439-95-4. Subject Subsets: Human Nutrition N2 - For 104 normal male and female volunteers, aged 11-75 years, the magnesium concentration (mEq/litre) averaged 1.63±0.01 in blood plasma, 4.55±0.06 in erythrocytes and 19.6±0.03 in mononuclear blood cells; the amount in mononuclear blood cells was 72.8±1.0 fg per cell. There was no effect of age (P<0.05) on these values. KW - age KW - blood KW - Magnesium KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429727&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy balance, body size, and cancer. AU - Albanes, D. JO - Critical Reviews in Oncology/Hematology JF - Critical Reviews in Oncology/Hematology Y1 - 1990/// VL - 10 IS - 3 SP - 283 EP - 303 AD - Albanes, D.: Cancer Prevention Studies Branch, EPN-211, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892-4200, USA. N1 - Accession Number: 19931457237. Publication Type: Journal Article. Language: English. Number of References: 245 ref. Subject Subsets: Human Nutrition N2 - Research dealing with energy balance and body size as they relate to human neoplasms is reviewed. Increased energy intake and physical inactivity heighten the risk of breast, large bowel and other neoplasms. Large body size and fatness, as measured by adult stature, body weight and body mass indices, are positively related to a variety of neoplasms, including breast, colorectum, prostate, endometrium, kidney and ovary, as well as to total neoplasm incidence or mortality in many investigations, although conflicting reports exist. Adult weight gain has also been specifically implicated in a few aetiologic studies of breast and large bowel neoplasms. Furthermore, increased birth weight and child stature have been linked to increased risk of leukaemia, lymphoma, osteogenic sarcoma and central nervous system malignancies between infancy and young adulthood. Greater body weight also adversely affects breast neoplasm survival. These findings are complementary and support a role for positive energy balance in promoting human carcinogenesis. Potential mechanisms are discussed. KW - Body weight KW - Carcinogenesis KW - Energy balance KW - Reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931457237&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hantavirus infection in the United States: epizootiology and epidemiology. AU - Yanagihara, R. JO - Reviews of Infectious Diseases JF - Reviews of Infectious Diseases Y1 - 1990/// VL - 12 IS - 3 SP - 449 EP - 457 AD - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5B-21, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517820. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Public Health N2 - Multiple species of murid and arvicolid (microtine) rodents serve as reservoir hosts of hantaviruses, the aetiologic agents of haemorrhagic fever with renal syndrome. Three antigenically distinct hantaviruses have been isolated from Rattus norvegicus, Mus musculus and Microtus pennsylvanicus captured in the USA, and serological evidence of a hantavirus enzootic has been found in several other indigenous rodent species. In residential districts of port cities such as Baltimore (Maryland), nearly 50% of R. norvegicus rats are infected with viruses that are serologically indistinguishable from disease-causing Hantavirus strains isolated from rats in the Far East. Despite the widespread distribution of Hantavirus-infected rodents, confirmed cases of haemorrhagic fever with renal syndrome have not been recognised in USA. Moreover, the overall risk of hantavirus infection in humans in USA is low, even among individuals who have frequent exposure to commensal and wild rodents. Studies are needed to define the clinical spectrum of hantavirus infection in humans in the USA. KW - Epidemiology KW - Haemorrhagic fever with renal syndrome KW - haemorrhagic fevers KW - Human diseases KW - infections KW - introduced species KW - Reviews KW - viral diseases KW - Zoonoses KW - USA KW - Hantavirus KW - Rats KW - Rattus norvegicus KW - Rodents KW - Bunyaviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Rattus KW - Murinae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - brown rat KW - exotic organisms KW - exotic species KW - hemorrhagic fever with renal syndrome KW - hemorrhagic fevers KW - introduced organisms KW - naturalized species KW - non-indigenous organisms KW - non-indigenous species KW - non-native organisms KW - non-native species KW - nonindigenous organisms KW - nonindigenous species KW - Norway rat KW - United States of America KW - viral infections KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517820&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental basis for use of fluconazole for preventive or early treatment of disseminated candidiasis in granulocytopenic hosts. AU - Walsh, T. J. AU - Lee, J. AU - Aoki, S. AU - Mechinaud, F. AU - Bacher, J. AU - Lecciones, J. AU - Thomas, V. AU - Rubin, M. AU - Pizzo, P. A. JO - Reviews of Infectious Diseases JF - Reviews of Infectious Diseases Y1 - 1990/// VL - 12 IS - Suppl. 3 SP - S307 EP - S317 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901207008. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 27 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - To determine the potential for the use of fluconazole for prevention and treatment of disseminated Candida albicans infection in granulocytopenic patients, its activity and pharmacokinetics were investigated in models of acute, subacute and chronic forms of disseminated candidosis in persistently granulocytopenic rabbits. Fluconazole was administered for systemic prophylaxis, early treatment and delayed treatment. Single-dose and steady-state plasma pharmacokinetics, tissue penetration and dose-response studies of fluconazole were studied in subacutely infected granulocytopenic rabbits. Fluconazole was more effective when used for systemic prophylaxis or early treatment of disseminated candidosis than for delayed treatment. Fluconazole was as effective as amphotericin B plus flucytosine in preventive and early treatment of disseminated candidosis but was significantly less effective than amphotericin plus flucytosine in the treatment of chronic candidosis. Dose-response studies demonstrated that the antifungal effect of fluconazole was dose- and time-dependent. Studies of the pharmacokinetics of fluconazole in rabbits demonstrated a long half-life in plasma and a large volume of distribution, properties that correspond to the attainment of high levels of penetration into tissues at multiple organ sites. It is concluded that fluconazole is effective for prevention and early treatment of disseminated candidosis in persistently granulocytopenic rabbits and that the evaluation of its use in preventive or early treatment of disseminated candidosis in carefully designed clinical trials is warranted. KW - Antifungal agents KW - fluconazole KW - generalized infections KW - infections KW - pharmacokinetics KW - predisposition KW - prophylaxis KW - therapy KW - Candida albicans KW - mice KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Fluconazole -a novel advance in therapy for systemic fungal infections KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207008&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increasing usage of systemic antifungal agents. AU - Walsh, T. J. AU - Jarosinski, P. F. AU - Fromtling, R. A. JO - Diagnostic Microbiology and Infectious Disease JF - Diagnostic Microbiology and Infectious Disease Y1 - 1990/// VL - 13 IS - 1 SP - 37 EP - 40 SN - 0732-8893 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901205910. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 1397-89-3, 2022-85-7, 65277-42-1. Subject Subsets: Medical & Veterinary Mycology N2 - Findings of the Committee on Antifungal Therapeutics of the Medical Mycology Society of the Americas which evaluated the chronological trends of worldwide antifungal usage since 1983 are summarized. During 1983-1987, worldwide sales of the 3 principal systemic antifungal compounds, ketoconazole, amphotericin B and flucytosine, increased substantially. Results of studies at a large medical referral centre indicated that this was due to a combination of increased usage and increased cost of the antifungals. The implications of these trends toward management of systemic mycoses are discussed. KW - Amphotericin B KW - Antifungal agents KW - Flucytosine KW - Ketoconazole KW - mycoses KW - therapy KW - 5-fluorocytosine KW - fungistats KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205910&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - International differences in body height and weight and their relationship to cancer incidence. AU - Albanes, D. AU - Taylor, P. R. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1990/// VL - 14 IS - 1 SP - 69 EP - 77 SN - 0163-5581 AD - Albanes, D.: EPN-211, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19901452595. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition N2 - The relation between body size (adult height and weight) and cancer incidence was investigated in an international ecological study of 24 populations. Site-specific and total cancer incidence rates (age-standardized) from 1973 to 1977 were correlated with body size data generally obtained between 1954 and 1974. All-sites cancer incidence was highly correlated with height among men and women. Among men, there were significant correlations between height and cancers of the central nervous system, prostate, bladder, pancreas, lung and colon. Significant correlations were observed for cancers of the rectum, pancreas, ovary, central nervous system, breast, uterine corpus and bladder in women. Adjustment for weight altered these correlations only minimally. Weight was significantly correlated with all-sites cancer only among women and site-specific correlations were significant for the same sites as for height, but the magnitude of the correlation coefficients was somewhat diminished. In addition, adjustment for height greatly reduced the correlations with weight. These findings support previously observed associations between height and specific cancers (e.g., breast and colon) and identify several additional cancer sites that may be similarly related. KW - body weight KW - Carcinogenesis KW - height KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452595&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Widespread visceral calcifications in disseminated Pneumocystis carinii infection: CT characteristics. AU - Feuerstein, I. M. AU - Francis, P. AU - Raffeld, M. AU - Pluda, J. JO - Journal of Computer Assisted Tomography JF - Journal of Computer Assisted Tomography Y1 - 1990/// VL - 14 IS - 1 SP - 149 EP - 151 SN - 0363-8715 AD - Feuerstein, I. M.: Diagnostic Radiology Department, Bldg. 10, Rm. 1C660, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910870622. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology N2 - The case of a 29-year-old man from the USA, with AIDS and disseminated P. carinii infection, is presented. Calcifications of similar character were found by CT in the lymph nodes, spleen, liver, and kidneys. Biopsy of a calcified axillary lymph node demonstrated necrotizing granulomatous lymphadenitis, with Pneumocystis organisms and dystrophic calcifications clustered centrally within the granulomas. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - case reports KW - computed tomography KW - diagnosis KW - disseminated infections KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870622&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Atypical pathologic manifestations of Pneumocystis carinii pneumonia in the acquired immune deficiency syndrome. Review of 123 lung biopsies from 76 patients with emphasis on cysts, vascular invasion, vasculitis, and granulomas. AU - Travis, W. D. AU - Pittaluga, S. AU - Lipschik, G. Y. AU - Ognibene, F. P. AU - Suffredini, A. F. AU - Masur, H. AU - Feuerstein, I. AU - Kovacs, J. AU - Pass, H. I. AU - Condron, K. S. AU - Shelhamer, J. H. JO - American Journal of Surgical Pathology JF - American Journal of Surgical Pathology Y1 - 1990/// VL - 14 IS - 7 SP - 615 EP - 625 SN - 0147-5185 AD - Travis, W. D.: Laboratory of Pathology, Building 10, Room 2N212, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910870659. Publication Type: Journal Article. Language: English. Number of References: 80 ref. Subject Subsets: Protozoology N2 - The frequency of atypical pathological manifestations of P. carinii pneumonia (PCP) were studied in 123 lung biopsy specimens from 76 National Institutes of Health patients from Maryland, USA, with the acquired immune deficiency syndrome. The following atypical features were observed: interstitial (63%) and intraluminal (36%) fibrosis, absence of alveolar exudate (19%), numerous alveolar macrophages (9%), granulomatous inflammation (5), hyaline membranes (4%), marked interstitial pneumonitis (3%), parenchymal cavities (2%), interstitial microcalcification (2%), minimal histological reaction (2%), and vascular invasion with vasculitis (1%). These atypical features are discussed with emphasis on the significance of cavities, vascular invasion, vasculitis, and granulomas. Immunohistochemical staining with MAbs to the 2G2 and 6B8 antigens of P. carinii in paraffin-embedded lung biopsy specimens, did not indicate any diagnostic advantage over routine methenamine silver stains. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - lungs KW - Opportunistic infections KW - parasites KW - pathology KW - Maryland KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - prevalence KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870659&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet and oral and pharyngeal cancer among Blacks. AU - Gridley, G. AU - McLaughlin, J. K. AU - Block, G. AU - Blot, W. J. AU - Winn, D. M. AU - Greenberg, R. S. AU - Schoenberg, J. B. AU - Preston-Martin, S. AU - Austin, D. F. AU - Fraumeni, J. F., Jr. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1990/// VL - 14 IS - 3&4 SP - 219 EP - 225 SN - 0163-5581 AD - Gridley, G.: National Cancer Institute, Division of Cancer Etiology, Epidemiology and Biostatistics Program, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19911432062. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition N2 - Data from a population-based multicentre case-control study were examined to assess the relationship between diet and oral and pharyngeal cancer among blacks. An increased intake of fruits and vegetables was associated with a decreased risk for oral cancer among men and women, although the protective effect was stronger among men. Risk also declined in both sexes with an increase in the consumption of vitamin C and fibre and in men only for carotene and vitamin E. No associations were found with an intake of smoked, pickled, or charcoal-grilled meats or of hot beverages. However, the consumption of nitrite-containing meats was linked to increased risk among men. The dietary patterns of risk for blacks were generally similar to those previously reported for whites; however, a lower consumption of fruits and vegetables among blacks may contribute to their higher rates of oral and pharyngeal cancer. KW - carcinogenesis KW - diets KW - Ethnic groups KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911432062&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy expenditure in the obese: is there a thrifty gene? AU - Ravussin, E. AU - Bogardus, C. JO - Infusionstherapie, Internationale Zeitschrift für Infusionstherapie, Klinische Ernährung und Transfusionsmedizin JF - Infusionstherapie, Internationale Zeitschrift für Infusionstherapie, Klinische Ernährung und Transfusionsmedizin Y1 - 1990/// VL - 17 IS - 2 SP - 108 EP - 112 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19911431625. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - At present 7000 to 8000 Pima Indians live in the southwestern desert of Arizona, USA. The prevalence of type II diabetes in this population exceeds 45% and more than 75% of the Pimas are obese. In 1962, Neel [American Journal of Human Genetics (1962) 14, 353] proposed that obesity in populations like the Pima Indians might be the expression of a "thrifty gene" which becomes detrimental with progress. Since 1982, longitudinal studies have been made including estimations of metabolic rate in 200 non-diabetic Pima Indians and have shown that at any given body weight and body composition, there is quite a large variability in the resting metabolic rate which is not accounted for by intra-individual variability or errors of the methods. Metabolic rate after adjustment for body composition and body weight is a familial trait. A low metabolic rate is a risk factor for body weight gain. In response to body weight gain, there is a 'normalization' of the resting metabolic rate. KW - Ethnic groups KW - metabolism KW - obesity KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431625&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fungal infections in the pediatric cancer patient. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Seminars in Oncology JF - Seminars in Oncology Y1 - 1990/// VL - 17 IS - 3, Suppl. 6 SP - 6 EP - 9 AD - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210389. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Factors such as neutropenia which predispose paediatric cancer patients to fungal infections, common sites of infection, the emerging problem of hepatic Candida infections and antifungal therapy, both experimental efficacy studies and empirical use in high-risk patients, are discussed. KW - children KW - infections KW - liver KW - Mycoses KW - neoplasms KW - neutropenia KW - predisposition KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - cancers KW - Fungal infections in the cancer patient - clinical experience with fluconazole KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210389&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recominant baculovirus-infected insect cells. AU - Marcy, A. I. AU - Olivo, P. D. AU - Challberg, M. D. AU - Coen, D. M. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1990/// VL - 18 IS - 5 SP - 1207 EP - 1215 SN - 0305-1048 AD - Marcy, A. I.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900598554. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Biochemical characterization of the herpes simplex virus (HSV) DNA polymerase, a model DNA polymerase and an important target for antiviral drugs, has been limited by a lack of pure enzyme in sufficient quantity. To overcome this limitation, the HSV DNA polymerase gene was introduced into the baculovirus, Autographa californica nuclear polyhedrosis virus, under the control of the polyhedrin promotor to give rise to a recombinant baculovirus, BP58. BP58-infected Spodoptera frugiperda insect cells expressed a polypeptide that was indistinguishable from authentic polymerase by several immunological and biochemical properties, at levels approximately 10-fold higher per infected cell than found in HSV-infected Vero cells. The DNA polymerase was purified to apparent homogeneity from BP58-infected insect cells. Using activated DNA as primer-template, the purified enzyme exhibited specific activity similar to that of enzyme isolated from HSV-infected Vero cells, indicating that additional polymerase-associated proteins from HSV-infected cells are not critical for activity with this primer-template. 3′-5′ exonuclease activity co-purified with the BP58-expressed HSV DNA polymerase, demonstrating that this activity is intrinsic to the polymerase polypeptide. The purified enzyme also exhibited RNAse H activity. The recombinant baculovirus should permit detailed biochemical and biophysical studies of this enzyme. KW - biotechnology KW - Cell lines KW - DNA KW - Enzymes KW - Gene expression KW - herpes simplex viruses KW - human herpesviruses KW - Baculovirus KW - Herpesviridae KW - Spodoptera frugiperda KW - Baculoviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Spodoptera KW - Noctuidae KW - Lepidoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Herpesviridae KW - Cloning KW - deoxyribonucleic acid KW - herpes simplex virus KW - Human herpesvirus KW - Vertebrate viruses KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biological Control (HH100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900598554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A heat shock protein gene in Giardia lamblia unrelated to HSP70. AU - Aggarwal, A. AU - Cruz, V. F. de la AU - Nash, T. E. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1990/// VL - 18 IS - 11 SP - 3409 EP - 3409 SN - 0305-1048 AD - Aggarwal, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872903. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Protozoology; Agricultural Biotechnology N2 - A 4.2 kb HindIII gene fragment from G. lamblia trophozoites strain WB, selected by 32P labelled HSP70 clone pPW229 of Drosophila was cloned into pUC19 (pUCG2c). The sequence was determined by sequencing both strands of overlapping restriction fragments. The sequence contained a 5′ non-coding region of 141 bases followed by 1593 nucleotides showing a single continuous open reading frame starting with a putative initiator at position 142. No homology in the coding sequence was identified with D. melanogaster HSP70 or any other HSPs reported in literature. However, an HSP like motif at position 73-86 and a TATAA box at position 109-113 were identified which suggests that functional controlling elements are present in this gene. KW - Biotechnology KW - heat shock proteins KW - Molecular genetics KW - nucleotide sequences KW - parasites KW - GIARDIA DUODENALIS KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872903&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary protein and blood pressure in monozygotic twins. AU - Havlik, R. J. AU - Fabsitz, R. R. AU - Kalousdian, S. AU - Borhani, N. O. AU - Christian, J. C. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1990/// VL - 19 IS - 1 SP - 31 EP - 39 SN - 0091-7435 AD - Havlik, R. J.: R. R. Fabsitz, National Heart, Lung, and Blood Institute, Federal Building, Room 300, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429742. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - Cross-sectional studies relating blood pressure to dietary intake have been confounded due to the high genetic component of blood pressure. Intervention studies, using the same subject as his own control, often encounter additional problems when subjects are asked to adhere to an alternate diet. The National Heart, Lung, and Blood Institute Twin Study of middle-aged men provided information concerning the possible relation of food-frequency-estimated nutrient intake to blood pressure while controlling for genetic effects in a free-living group of subjects. Using differences in monozygotic twins, a direct association of dietary protein intake and diastolic blood pressure was identified and persisted after adjustment for known covariates of blood pressure. Adjusting for known covariates and holding total calories constant, a 9-g difference in daily protein intake was directly associated with a 1 mm Hg difference in diastolic blood pressure. For protein intake as a percentage of total calories, a 2.18% difference was directly associated with a 1 mm Hg difference in diastolic blood pressure. The co-twin-control method provides a powerful design to investigate the interrelation between nutrients and blood pressure in an observational as well as an experimental situation. KW - Blood pressure KW - protein intake KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - N-acetyltransferase activity in bilharzial infested mice. AU - Zakhary, N. I. AU - Dahawy, H. S. AU - El-Asser, A. B. JO - Pakistan Journal of Biochemistry JF - Pakistan Journal of Biochemistry Y1 - 1990/// VL - 23 IS - 2 SP - 63 EP - 68 SN - 0300-8185 AD - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo, Egypt. N1 - Accession Number: 19930808441. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Helminthology KW - duodenum KW - enzyme activity KW - experimental infections KW - helminths KW - human diseases KW - laboratory animals KW - liver KW - parasites KW - pathology KW - transferases KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808441&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy metabolism and obesity. / Métabolisme énergétique et obésité. AU - Ravussin, E. AU - Zurlo, F. JO - Cahiers de Nutrition et de Diététique JF - Cahiers de Nutrition et de Diététique Y1 - 1990/// VL - 25 IS - 3 SP - 171 EP - 175 SN - 0007-9960 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19911437088. Publication Type: Journal Article. Language: French. Language of Summary: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Relations between energy metabolism and obesity are reviewed. The author's own research on energy expenditure and its components (resting metabolic rate (RMR), heat effect of food and energy cost of physical activity) in more than 400 persons showed the potential role of energy expenditure in the development of obesity. From a methodological viewpoint, it is insufficient to express RMR in relation to fat-free mass, although it explains 82% of the variance of RMR. A multiple regression line taking into account fat-free mass, body fat, age and sex was used to obtain a predicted value and to analyse the measured values with regard to the predicted value. It seemed that experimental values could vary around the predicted value by some 300 kcal which underlines the heterogeneity of individuals beyond their difference in body composition. This variability of energy metabolism is in a large part determined genetically. Variations in energy expenditure above or below the predicted value are indicators of the ability of persons to gain weight with time and represent a predictive factor of obesity. A reduction in the capacity to oxidize fats is also linked to an increased risk to gain weight. KW - energy metabolism KW - Obesity KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911437088&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutations with multiple independent origins in surface antigens mark the targets of biological selective pressure. AU - McCutchan, T. F. AU - Waters, A. P. JO - Immunology Letters JF - Immunology Letters Y1 - 1990/// VL - 25 IS - 1-3 SP - 23 EP - 26 SN - 0165-2478 AD - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869109. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology N2 - The existence and importance of a small subset of mutations in Plasmodium falciparum genes that continually reoccur in separated populations is documented. A description of how to identify recurrent mutations using a novel application of pre-existing computer programs designed to trace genealogy is given. The most striking example of this phenomenon occurred in the cytotoxic T-cell epitope of the circumsporozoite (CS) protein of P. falciparum, where identical sequence types clearly have multiple independent origins. The importance of this observation is that it conclusively demonstrates selective pressure on these sequences and indicates that there is a significant natural mechanism relating to the CS protein that affects the success of malaria sporozoites. KW - circumsporozoite protein KW - Evolution KW - genetics KW - Human diseases KW - mutations KW - natural selection KW - parasites KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunogenicity of Plasmodium falciparum sexual stage antigens: implications for the design of a transmission blocking vaccine. AU - Kaslow, D. C. JO - Immunology Letters JF - Immunology Letters Y1 - 1990/// VL - 25 IS - 1-3 SP - 83 EP - 86 SN - 0165-2478 AD - Kaslow, D. C.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room B1-37, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869120. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology N2 - A discussion of the implications for the design of a transmission blocking vaccine for P. falciparum is presented. Immunogenicity of sexual stage antigens and boosting of transmission blocking antibodies following a natural infection, are 2 critical factors in the design of an effective, subunit vaccine to block the transmission of malaria from man to mosquito. Immunogenicity and boosting are both T cell-dependent. Antigens, such as the 230 000 MW, the 48/45 000 MW, and the 40/10 000 MW, expressed early in the extracellular forms of the sexual stage of P. falciparum, have limited immunogenicity in humans and in mice. In contrast, Pfs25, expressed predominantly in zygotes and ookinetes, has widespread immunogenicity in mice. Pfs25, expressed by a recombinant vaccinia virus (vSIDK), is also widely immunogenic in mice, and induces transmission blocking antibodies following multiple inoculations with vSIDK. The implications of these immunogenicity data are discussed relative to the design of an effective transmission blocking vaccine. KW - antigens KW - Experimental infection KW - genetic regulation KW - Human diseases KW - immune response KW - parasites KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenicity KW - experimental transmission KW - immunity reactions KW - immunogens KW - immunological reactions KW - sexual stages KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869120&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cellular mechanisms in immunity to blood stage infection. AU - Kumar, S. AU - Miller, L. H. JO - Immunology Letters JF - Immunology Letters Y1 - 1990/// VL - 25 IS - 1-3 SP - 109 EP - 114 SN - 0165-2478 AD - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869125. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology N2 - Mechanisms of immunity to blood stage infection in the mouse malarias Plasmodium vinckei and P. yoelii 17X were investigated. Infection with P. vinckei was uniformly lethal, whereas P. yoelii 17X caused a self-limited, nonlethal infection. Transfer of immune CD4+ T cells conferred protection against P. yoelii in nude mice. Previous studies by others had suggested that immunity to P. yoelii may be related to MHC class I expression on reticulocytes, and found that CD8+ T cells alone transferred protection in immunodeficient mice. However, in these experiments, immune CD8+ T cells failed to transfer protection. In the P. vinckei system, both B cell-deficient and immunologically intact mice developed immunity to P. vinckei after parasite infection and drug cure. In vivo depletion of CD4+ T cells abrogated immunity in these immune mice. Adoptive transfer of CD4+ T cells failed to protect nude or normal mice from P. vinckei infection, but the transfer of immune CD4+ T cells reconstituted immunity in CD4-depleted immune mice. Splenectomy of immune mice resulted in the complete loss of immunity. Despite the fact that immunity to P. vinckei could be achieved with live parasite infection and drug cure, immunization of mice with killed P. vinckei with various adjuvants failed to protect mice from live challenge. In contrast, immunization with killed P. vinckei antigens in combination with attenuated Salmonella typhimurium SL3235 induced a high degree of protective immunity. These results suggest that induction of immunity against virulent malarias requires both induction of CD4+ T cells and certain splenic alterations caused by parasite infection or S. typhimurium. Successful vaccination against blood stage infection may require a combination of malarial antigen(s) to induce protective T cells and an agent which could create a malarial-type spleen. A vaccine comprising an attenuated strain of Salmonella expressing malarial genes might induce the cellular immunity and splenic changes required and, thereby, protect against human malarias. KW - Disease models KW - Human diseases KW - immunity KW - Laboratory animals KW - parasites KW - T lymphocytes KW - Apicomplexa KW - mice KW - Plasmodium KW - Plasmodium vinckei KW - Plasmodium yoelii KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Method for in situ hybridization to polytene chromosomes from ovarian nurse cells of Anopheles gambiae (Diptera: Culicidae). AU - Graziosi, C. AU - Sakai, R. K. AU - Romans, P. AU - Miller, L. H. AU - Wellems, T. E. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1990/// VL - 27 IS - 5 SP - 905 EP - 912 SN - 0022-2585 AD - Graziosi, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900502326. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - A procedure for in situ hybridization to polytene chromosomes from the ovarian nurse cells of A. gambiae was developed. This procedure involves a modification of established methods for Drosophila larval salivary gland polytene chromosomes. Treatment of chromosome squashes with xylene followed by slow rehydration provides required resolution of chromosome banding patterns, possibly because fatty contaminants are removed from ovarian nurse cell preparations. Using this procedure, unique DNA sequences from a genomic library of A. gambiae were mapped on adult mosquito polytene chromosomes. The ability to locate genetic markers on chromosomes will allow correlation of physical and genetic maps. Such maps will facilitate identification of genetic loci and expand the knowledge of the genomic organization of A. gambiae. KW - Biotechnology KW - DNA KW - DNA hybridization KW - Gene mapping KW - genetics KW - in situ hybridization KW - Molecular genetics KW - Nucleotide sequences KW - polytene chromosomes KW - Techniques KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - Chromosome mapping KW - deoxyribonucleic acid KW - DNA sequences KW - mosquitoes KW - Techniques and Methodology (ZZ900) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Aquatic Biology and Ecology (MM300) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900502326&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Administration of potassium iodide to normal volunteers does not increase killing of Sporothrix schenckii by their neutrophils or monocytes. AU - Rex, J. H. AU - Bennett, J. E. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1990/// VL - 28 IS - 3 SP - 185 EP - 189 SN - 0268-1218 AD - Rex, J. H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901206974. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7681-11-0. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - The mechanism by which iodide cures sporotrichosis was postulated to be an improvement in phagocyte-mediated killing of the causal fungus, S. schenckii. It was found that both neutrophils and monocytes could readily kill the fungus and that killing could be blocked by adding inhibitors of oxidative metabolism. Iodide, administered to 4 volunteers for 1 wk, raised their serum iodide level 213-fold but failed to improve killing of S. schenckii by their neutrophils or monocytes in a killing assay in vitro. Furthermore, addition of iodide directly to neutrophils at concn as high as 100µM did not augment killing. KW - Antifungal agents KW - immunology KW - monocytes KW - neutrophils KW - phagocytosis KW - pharmacodynamics KW - potassium iodide KW - therapy KW - Sporothrix schenckii KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - drug action KW - fungistats KW - fungus KW - Hyphomycetes KW - killing KW - mechanism of drug action KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive fusariosis associated with an injury by a stingray barb. AU - Hiemenz, J. W. AU - Kennedy, B. AU - Kwon-Chung, K. J. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1990/// VL - 28 IS - 3 SP - 209 EP - 213 SN - 0268-1218 AD - Hiemenz, J. W.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901206977. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - A case is reported in a previously healthy 34-yr-old man who suffered a wound to the dorsal ulnar aspect of his right hand by a stingray barb while fishing off the east coast of Florida. Two weeks after the imbedded barb had been surgically removed, an erythematous lesion developed around the wound. Histopathological and microbiological studies revealed infection caused by Fusarium solani. The patient was successfully treated with debridement and skin grafting in conjunction with ketoconazole therapy. KW - hosts KW - infections KW - invasion KW - Marine animals KW - mycoses KW - stings KW - transmission KW - wounds KW - USA KW - Dasyatidae KW - fishes KW - Fusarium KW - Haematonectria haematococca KW - man KW - Rajiformes KW - Chondrichthyes KW - fishes KW - vertebrates KW - Chordata KW - animals KW - aquatic organisms KW - aquatic animals KW - eukaryotes KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - Fusarium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Haematonectria KW - America (North) KW - fungus KW - Fusarium solani KW - Hyphomycetes KW - marine species KW - sting-ray injury KW - United States of America KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206977&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Is Candida stellatoidea disappearing from the vaginal mucosa ? AU - Kwon-Chung, K. J. AU - Wickes, B. L. AU - Salkin, I. R. AU - Kotz, H. L. AU - Sobel, J. D. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1990/// VL - 28 IS - 3 SP - 600 EP - 601 SN - 0095-1137 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901205849. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 681 vaginal isolates of germ tube-positive or germ tube-untested white, yeastlike fungi obtained from patients in various cities of the USA were tested for the presence of C. stellatoidea (type I). Only 1 of the 681 isolates was identified as C. stellatoidea. KW - hosts KW - infections KW - vagina KW - USA KW - Candida albicans KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Candida stellatoidea KW - fungus KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205849&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trichosporon beigelii, an emerging pathogen resistant to amphotericin B. AU - Walsh, T. J. AU - Melcher, G. P. AU - Rinaldi, M. G. AU - Lecciones, J. AU - McGough, D. A. AU - Kelly, P. AU - Lee, J. AU - Callender, D. AU - Rubin, M. AU - Pizzo, P. A. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1990/// VL - 28 IS - 7 SP - 1616 EP - 1622 SN - 0095-1137 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901206583. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - T. beigelii caused fatal disseminated infections that were resistant to amphotericin B in 2 granulocytopenic patients (18- and 65-yr-old men). In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concn in serum. The min. lethal concn for both isolates was ≥18 µg/ml. Five of 7 other isolates were found to have a similar pattern of amphotericin B resistance. That the min. lethal concn of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. It is concluded that T. beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance is correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. KW - amphotericin B KW - Antifungal agents KW - death KW - disseminated infections KW - generalized infections KW - hosts KW - immunocompromised hosts KW - infections KW - patients KW - Piedra KW - predisposition KW - resistance KW - USA KW - man KW - Trichosporon beigelii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - amphotericin B resistance KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - United States of America KW - white KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206583&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Patterns of morphologic variation among isolates of Trichosporon beigelii. AU - Lee, J. W. AU - Melcher, G. A. AU - Rinaldi, M. G. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1990/// VL - 28 IS - 12 SP - 2823 EP - 2827 SN - 0095-1137 AD - Lee, J. W.: T. J. Walsh, Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901207824. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Considerable variability in colony and microscopic morphology among isolates of T. beigelii was observed. Deeply invasive clinical isolates showed 4 distinct morphotypes and spontaneous conversions among certain morphotypes and grew well at 37°C. In contrast, superficial clinical and environmental isolates did not demonstrate such morphotypes or conversions and most grew poorly at 37°C. It is concluded that the morphological and physiological features of invasive clinical isolates of T. beigelii follow certain patterns distinct from those of superficial clinical and environmental isolates. KW - morphology KW - Trichosporon beigelii KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207824&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequential resonance assignment and secondary structure determination of the Ascaris trypsin inhibitor, a member of a novel class of proteinase inhibitors. AU - Gronenborn, A. M. AU - Nilges, M. AU - Peanasky, R. J. AU - Clore, G. M. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1990/// VL - 29 IS - 1 SP - 183 EP - 189 SN - 0006-2960 AD - Gronenborn, A. M.: Laboratory of Chemical Physics, Building 2, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900868011. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9002-07-7. Subject Subsets: Helminthology N2 - The solution conformation of the Ascaris suum trypsin inhibitor, a member of a novel class of proteinase inhibitors, was investigated by nuclear magnetic resonance spectroscopy. Complete sequence-specific assignments of the 1H NMR spectrum were obtained by using a number of 2-dimensional techniques for identifying through-bond and through-space (<5-Å) connectivities. Elements of regular secondary structure were identified on the basis of a qualitative interpretation of the nuclear Overhauser enhancement, coupling constant, and amide exchange data. These are 2 β-sheet regions. One double-stranded antiparallel β-sheet comprises residues 11-14 (strand 1) and 37-39 (strand 2). The other triple-stranded sheet is formed by 2 antiparallel strands comprising residues 45-49 (strand 4) and 53-57 (strand 5) connected by a turn (residues 50-52), and a small strand consisting of residues 20-22 (strand 3) that is parallel to strand 4. KW - Biochemistry KW - Enzyme inhibitors KW - enzymes KW - helminths KW - Human diseases KW - Nuclear magnetic resonance KW - parasites KW - proteinase inhibitors KW - Trypsin KW - Ascaris suum KW - Nematoda KW - Ascaris KW - Ascarididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Ascaridida KW - nematodes KW - parasitic worms KW - protease inhibitors KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900868011&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Functional consequences of the proteolytic removal of regulatory serines from the nonhelical tailpiece of Acanthamoeba myosin II. AU - Sathyamoorthy, V. AU - Atkinson, M. A. L. AU - Bowers, B. AU - Korn, E. D. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1990/// VL - 29 IS - 15 SP - 3793 EP - 3797 SN - 0006-2960 AD - Sathyamoorthy, V.: E.D. Korn, Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869858. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 56-45-1. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activity of myosin II from A. castellanii is regulated by phosphorylation of 3 serines in its 29-residue, nonhelical, COOH-terminal tailpiece, i.e., serines-1489, -1494, and -1499 or, in reverse order, residues 11, 16, and 21 from the COOH terminus. To investigate the essential requirements for regulation, myosin II filaments in the presence of F-actin were digested by arginine-specific submaxillary gland protease. Two-dimensional peptide mapping of purified, cleaved myosin II showed that the 2 most terminal phosphorylation sites, serines-1494 and -1499, had been removed. Cleaved dephosphorylated myosin II retained full actin-activated Mg2+-ATPase activity (with no change in Vmax or Kapp) and the ability to form filaments similar to those of the native enzyme. However, higher Mg2+ concentrations were required for both filament formation and maximal ATPase activity. The one remaining regulatory serine in the cleaved myosin II was phosphorylatable by myosin II heavy-chain kinase, and phosphorylation inactivated the actin-activated Mg2+-ATPase activity, as in the case of the native myosin II. Also as in the native myosin II, phosphorylated cleaved myosin II inhibited the actin-activated Mg2+-ATPase activity of dephosphorylated cleaved myosin II when the 2 were copolymerized. These results suggest that at least 18 of the 29 residues in the nonhelical tailpiece of the heavy chain are not required for either actin-activated Mg2+-ATPase activity or filament formation and that phosphorylation of Ser-1489 is sufficient to regulate the actin-activated Mg2+-ATPase activity of myosin II. KW - Biochemistry KW - Enzymes KW - Human diseases KW - parasites KW - proteins KW - regulation KW - serine KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muscle filaments KW - myosin II KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869858&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinol metabolism in rats with low vitamin A status: a compartmental model. AU - Lewis, K. C. AU - Green, M. H. AU - Green, J. B. AU - Zech, L. A. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1990/// VL - 31 IS - 9 SP - 1535 EP - 1548 SN - 0022-2275 AD - Lewis, K. C.: Laboratory of Mathematical Biology, Room 4B-56, Building 10, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911433601. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - A compartmental model was developed to describe the metabolism of vitamin A in weaning male Sprague-Dawley rats with low vitamin A status maintained by a low dietary intake of vitamin A (about 2 µg retinol equivalent daily). The model predicted a vitamin A utilization rate of 1.65 µg retinol equivalents daily with urine and faeces accounting for most of the output. The plasma retinol turnover rate was about 20 µg retinol equivalents daily; this was 12 times the utilization rate, which suggested that, of the large amount of retinol moving through the plasma each day, less than 10% was being utilized. Similarly, as compared to the whole body utilization rate, there was a relatively higher turnover rate of retinol in the kidneys, carcass and liver, coupled with a high degree of recycling of vitamin A through these tissues. Of the total vitamin A that entered the liver from all sources including the diet, about 86% was mobilized into the plasma. Similarly, of the vitamin A that entered the carcass, about 76% was returned to the plasma. All of the retinol that entered the kidneys was modelled as recycling to the plasma. KW - metabolism KW - Retinol KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433601&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Both apolipoproteins B-48 and B-100 are synthesized and secreted by the human intestine. AU - Hoeg, J. M. AU - Sviridov, D. D. AU - Tennyson, G. E. AU - Demosky, S. J., Jr. AU - Meng, M. S. AU - Bojanovski, D. AU - Safonova, I. G. AU - Repin, V. S. AU - Kuberger, M. B. AU - Smirnov, V. N. AU - Higuchi, K. AU - Gregg, R. E. AU - Brewer, H. B., Jr. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1990/// VL - 31 IS - 10 SP - 1761 EP - 1769 SN - 0022-2275 AD - Hoeg, J. M.: Building 10, Room 7N117, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19921440108. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition N2 - Intestinal organ cultures from 6 normal adults were incubated in the presence of protease inhibitors in media supplemented with [35S]methionine. Media from these cultures were evaluated by sequential NaDodSO4 polyacrylamide gel electrophoresis, radioautography and Western blot analyses, and intestinal biopsies were studied using immunohistochemistry. The relative abundance of apolipoprotein (apo) B-100 and apoB-48 mRNA was assessed using reverse transcriptase-polymerase chain reaction followed by primer extension. Although apoB-48 was the principal isoprotein that was newly synthesized by intestinal organ cultures, apoB-100 was also synthesized and secreted by human intestinal organ cultures with 16±3% of the intestinal apoB mRNA coding for apoB-100. The results establish that apoB-100 is produced by the human intestine. The synthesis of the atherogenic apoB-100 by the intestine has pathophysiologic implications for the development of diet-induced atherosclerosis. KW - Apolipoproteins KW - intestines KW - secretion KW - synthesis KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440108&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A short tetraponerine synthesis. AU - Jones, T. H. JO - Tetrahedron Letters JF - Tetrahedron Letters Y1 - 1990/// VL - 31 IS - 11 SP - 1535 EP - 1538 SN - 0040-4039 AD - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19910502839. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A short synthesis of (±)-tetraponerine (a tricyclic alkaloid which is a toxic component of the venom of Tetraponera ants) stereoisomer T-4 and its "unnatural" isomer from the appropriate pyridyl ketone is described. This study included an investigation of the stereoselectivity of pyridine reduction in the conversion of an amine to the unnatural isomer and T-4. KW - Alkaloids KW - chemistry KW - synthesis KW - toxins KW - Venoms KW - Formicidae KW - Hymenoptera KW - Tetraponera KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Formicidae KW - Tetraponerine KW - venom KW - Plant Composition (FF040) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Chemistry (ZZ600) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910502839&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Localization of nucleotide sequences on ovarian polytene chromosomes of the malaria vector Anopheles gambiae using in vitro hybridization. / Localizzazione di sequenze nucleotidiche sui cromosomi politenici ovarici del vettore di malaria Anopheles gambiae mediante ibridazione in situ.. AU - Graziosi, C. AU - Sakai, R. K. AU - Romans, P. AU - Miller, L. H. AU - Wellems, T. E. JO - Parassitologia JF - Parassitologia Y1 - 1990/// VL - 32 SP - 143 EP - 144 AD - Graziosi, C.: Malaria Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940502954. Publication Type: Journal Article. Language: Italian. Language of Summary: English. Number of References: 5 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - A procedure for in situ hybridization to ovarian polytene chromosomes of Anopheles gambiae was developed. Treatment of chromosome squashes with xylene provided required resolution of chromosome banding patterns. Using this procedure, 2 unique DNA sequences were mapped on adult mosquito polytene chromosomes. KW - DNA KW - DNA hybridization KW - molecular genetics KW - nucleotide sequences KW - Polytene chromosomes KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940502954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. AU - Shulman, L. E. JO - Arthritis and Rheumatism JF - Arthritis and Rheumatism Y1 - 1990/// VL - 33 IS - 7 SP - 913 EP - 917 SN - 0004-3591 AD - Shulman, L. E.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Room 4C-32, Building 31, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446001. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 73-22-3. Subject Subsets: Human Nutrition N2 - This editorial describes the history of the eosinophilia-myalgia syndrome (EMS), and reviews its clinical and pathological functions. The first notified cases occurred in the USA, and were drawn to the attention of the New Mexico Department of Health and Environment in October 1989. Subsequent reviews of eosinophil counts in laboratory records identified additional cases. Subjects suffering from EMS had been taking L-tryptophan products, and the US Food and Drug Administration ordered a recall of all single-entity products containing L-tryptophan. It is thought that a breakdown product of L-tryptophan, or a contaminant, is causing EMA. At 21 February 190 there had been 1305 reported cases, with 15 deaths. Patients with EMS were aged 5-84 years, and 85% were females. One third of patients had to be hospitalized. Attention is drawn to the similarity between EMS and the toxic oil syndrome that occurred in Spain in the early 1980s. KW - Eosinophilia KW - tryptophan KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446001&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of antifungal agents on the function of human neutrophils in vitro. AU - Roilides, E. AU - Walsh, T. J. AU - Rubin, M. AU - Venzon, D. AU - Pizzo, P. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1990/// VL - 34 IS - 2 SP - 196 EP - 201 SN - 0066-4804 AD - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901205742. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 65277-42-1, 79404-91-4. Subject Subsets: Medical & Veterinary Mycology N2 - The influence of 5 antifungal agents on polymorphonuclear leukocyte (PMN) function was investigated and compared with amphotericin B (Fungizone) (AmB). The in vitro effects of AmB, flucytosine, ketoconazole, fluconazole, Sch-39304 and cilofungin (LY121019) on chemotaxis, phagocytosis, oxidative metabolism of PMN as reflected by superoxide anion (O2-) generation, and intracellular killing of Candida albicans blastoconidia were examined. With regard to chemotaxis in response to N-formylmethionyl-leucyl-phenylalanine, as measured by the multiwell chamber method, AmB induced a marked decrease (≥5 µg/ml), whereas ketoconazole at 5 µg/ml enhanced it. Phagocytosis was significantly decreased after pretreatment of PMNs with AmB and Sch-39304 (>5 and 1-10 µg/ml, respectively). O2- production after stimulation of PMNs with N-formylmethionyl-leucyl-phenyl-alanine was significantly decreased by AmB (>5 µg/ml) and enhanced by Sch-39304 (1-5 µg/ml). In contrast, intracellular killing, as tested by methylene blue staining, was enhanced by ketoconazole (5 µg/ml) and Sch-39304 (1-5 µg/ml). Flucytosine, fluconazole and cilofungin did not affect PMN function at therapeutic concn. It is concluded that AmB, flucytosine, cilofungin and the newer azoles, at safely achievable concn, generally do not suppress PMN function in vitro and may enhance selective functions. KW - Amphotericin B KW - antifungal agents KW - antifungal properties KW - Cilofungin KW - Fluconazole KW - Flucytosine KW - immunology KW - Ketoconazole KW - leukocytes KW - pharmacodynamics KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - 5-fluorocytosine KW - anti-fungal properties KW - drug action KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - killing KW - leucocytes KW - mechanism of drug action KW - SCH 39304 KW - white blood cells KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates. AU - Walsh, T. J. AU - Lester-McCully, C. AU - Rinaldi, M. G. AU - Wallace, J. E. AU - Balis, F. M. AU - Lee, J. W. AU - Pizzo, P. A. AU - Poplack, D. G. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1990/// VL - 34 IS - 6 SP - 1281 EP - 1284 SN - 0066-4804 AD - Walsh, T. J.: Section of Infectious Diseases, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901206454. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 were investigated in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body wt). The mean CSF-to-plasma area under the curve ratio was 0.63 (±0.18, standard error of the mean); max. concn were 1.34 µg/ml (±0.18) in CSF and 1.96 µg/ml (±0.43) in plasma. The mean plasma half-life was 45.7 h (±11), and mean CSF half-life was 38.7 h (±3.5). The mean levels of SCH-39304 at 24 h were 1.48 µg/ml (±0.3) in plasma and 0.96 µg/ml (±0.12) in CSF. It is concluded that SCH-39304 effectively penetrates into CSF and achieves concentrations considered active against many opportunistic yeasts and that these concentrations are sustained in CSF for ≥24 h. KW - Antifungal agents KW - pharmacokinetics KW - monkeys KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fungistats KW - SCH 39304 KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206454&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits. AU - Walsh, T. J. AU - Lee, J. W. AU - Lecciones, J. AU - Kelly, P. AU - Peter, J. AU - Thomas, V. AU - Bacher, J. AU - Pizzo, P. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1990/// VL - 34 IS - 8 SP - 1560 EP - 1564 SN - 0066-4804 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901207110. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - The potential use of SCH 39304 was investigated for the prevention and treatment of disseminated candidosis in granulocytopenic patients. Its in vivo antifungal activity as preventive, early and late treatments was studied in 3 models (acute, subacute and chronic) of disseminated Candida albicans infection in persistently granulocytopenic rabbits. SCH 39304 was as effective as amphotericin B alone and fluconazole alone for the prevention of disseminated candidosis. SCH 39304 alone and fluconazole alone were as effective as amphotericin B plus flucytosine for early treatment of subacute disseminated candidosis. When treatment was delayed for 5 d to establish chronic disseminated candidosis, SCH 39304 was less effective than amphotericin B plus flucytosine. In comparison with different treatment regimens, SCH 39304 was more effective in early and preventive treatment. SCH 39304 was comparable to treatment control regimens in prevention and early treatment of subacute disseminated candidosis. KW - amphotericin B KW - Antifungal agents KW - fluconazole KW - flucytosine KW - generalized infections KW - infections KW - predisposition KW - prophylaxis KW - therapy KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 5-fluorocytosine KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - SCH 39304 KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207110&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits. AU - Lee, J. W. AU - Kelly, P. AU - Lecciones, J. AU - Coleman, D. AU - Gordee, R. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1990/// VL - 34 IS - 11 SP - 2240 EP - 2245 SN - 0066-4804 AD - Lee, J. W.: T. J. Walsh, Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19911207898. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 79404-91-4. Subject Subsets: Medical & Veterinary Mycology N2 - The plasma pharmacokinetics and tissue penetration of cilofungin were studied by intermittent and continuous infusion in rabbits. Following a single intravenous dose of 50 mg/kg body wt, the max. concn in plasma was 297±39 µg/ml, the area under the curve was 30.1±6.7 µg.h/ml, clearance was 30±10 ml/min per kg, volume of distribution was 0.85±0.23 litres/kg, half-life in distribution phase was 3.7±0.2 min (first 12 min postdose) and half-life in elimination phase was 12.9±0.7 min. When rabbits received cilofungin by continuous infusion (CI) at 10 mg/kg per h over 6 d, sustained concn in plasma of 290±56 µg/ml were seen, >50-fold higher than predicted if kinetics were linear. Similarly, at 5 mg/kg per h, high levels were also obtained. Such elevated levels in plasma would not have been predicted from the pharmacokinetic characteristics of cilofungin given as a single intravenous dose. Further pharmacokinetic studies at several rates of CI indicated that cilofungin elimination follows Michaelis-Menten kinetics. Simultaneous cilofungin levels in plasma and tissue were then determined for rabbits receiving 6 intravenous, intermittent doses (ID) of cilofungin at 15 mg/kg every 4 min and for rabbits receiving CI as described above. After ID, the mean of the ratios of cilofungin levels in tissue to those in plasma were highest for liver and bile but very low for cerebrum and cerebellum. After CI, ratios were as much as 89 times higher than for ID and significantly greater in the brain, choroid, kidney and bile (P<0.05). It is concluded that following a single dose of cilofungin, the compound is rapidly cleared via first-order kinetics and does not penetrate into the central nervous system, whereas following CI, cilofungin exhibits nonlinear saturable kinetics, is slowly cleared and significantly penetrates into central nervous system tissues. KW - Antifungal agents KW - Cilofungin KW - pharmacokinetics KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911207898&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heparin-like anticoagulant associated with systemic candidiasis. AU - Horne, M. K., III AU - Chao, E. S. AU - Wilson, O. J. JO - American Journal of Hematology JF - American Journal of Hematology Y1 - 1990/// VL - 35 IS - 1 SP - 37 EP - 42 SN - 0361-8609 AD - Horne, M. K., III: Hematology Section, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19911208465. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 15-yr-old girl with aplastic anaemia who developed a heparin-like anticoagulant during the course of systemic Candida albicans infection. This was initially detected in the laboratory by an elevation of the thrombin clotting time which corrected with toluidine blue but not by mixing with normal plasma. In vivo and in vitro the anticoagulant was remarkably resistant to neutralization by protamine sulfate. Nevertheless, its heparin-like nature was confirmed by its sensitivity to heparinase and its dependence on antithrombin III. Despite therapy, including amphotericin B, the patient died. Post-mortem cultures of the liver yielded C. albicans. KW - anticoagulants KW - aplastic anaemia KW - complications KW - generalized infections KW - hosts KW - infections KW - liver KW - predisposition KW - USA KW - Candida albicans KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aplastic anemia KW - fungus KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208465&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolate-dependent differences in the oxidative metabolism of Trypanosoma cruzi epimastigotes. AU - Engel, J. C. AU - Doyle, P. S. AU - Dvorak, J. A. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1990/// VL - 39 IS - 1 SP - 69 EP - 76 SN - 0166-6851 AD - Engel, J. C.: J.A. Dvorak, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862710. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology N2 - Epimastigote cultures of the 2 cloned T. cruzi stocks, CA-1/72 and HO-3/15, grown under identical conditions, differed both qualitatively and quantitatively in their cytochrome content. The CA-I/72 stock has a 4-fold higher cytochrome b content (19.2 nM/mg protein) than the HO-3/15 stock (4.9 nM/mg protein). Cytochrome o is present at 29 nM/mg protein in the CA-I/72 stock but is below detectable limits in the HO-3/15 stock. There is no inter-stock difference in oxygen utilization (12-15 nM O2/min/mg protein) during exponential growth. However, stationary phase CA-I/72 epimastigotes utilize twice as much oxygen as HO-3/15 epimastigotes. Oxygen utilization by HO-3/15 epimastigotes incubated in Dulbecco's phosphate buffer solution (starvation conditions), was stimulated earlier and to higher levels by the addition of glucose than by CA-I/72 epimastigotes under identical conditions. Under starvation conditions and with the cytochrome chain partially inhibited by antimycin A, (anti-A) the addition of glucose also increased oxygen utilization by CA-I/72 epimastigotes. In contrast, anti-A did not influence glucose-stimulated oxygen utilization by HO-3/15 epimastigotes. Following partial inhibition with anti-A, salicylhydroxamic acid produced an additional 50% inhibition in oxygen utilization in both stocks irrespective of the growth phase of the organisms. These data indicate that marked intra-specific differences in oxidative metabolism exist within the T. cruzi population and that an α-glycerophosphate oxidase or similar salicylhydroxamic acid-inhibitable compound may be present in the organism. KW - biochemistry KW - cytochromes KW - epimastigotes KW - Human diseases KW - metabolism KW - parasites KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of an Onchocerca volvulus cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera. AU - Lobos, E. AU - Altmann, M. AU - Mengod, G. AU - Weiss, N. AU - Rudin, W. AU - Karam, M. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1990/// VL - 39 IS - 1 SP - 135 EP - 145 SN - 0166-6851 AD - Lobos, E.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19900862717. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - The primary structure of an imunodominant antigen of O. volvulus was deduced from cDNA sequence analysis. Using affinity-purified antibody from onchocerciasis patients from West Africa, a cDNA clone was isolated from a λgt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a MW of 16 850 (consistent with the apparent MW of 18 000 of the immunoprecipitated in vitro translated product). The primary translation product contains a putative signal peptide of 16 amino acids. The mRNA coding for this antigen has an estimated size of 950 nucleotides. Immunoelectron microscopy established that the antigen encoded by this clone is present in the hypodermis, the cuticle, and in the uterus of the filarial worms. Since this antigen is recognized exclusively by sera from onchocerciasis patients, and not by other sera from patients infected by other filarial parasites, it may prove to be an especially valuable tool for improving the specific diagnosis of onchocerciasis.<new para>ADDITIONAL ABSTRACT:<new para>The antigen encoded by the clone is present in the hypodermis, cuticle, and uterus of Onchocerca volvulus worms. Antibodies to the antigen were detected in sera from onchocerciasis patients from West and East Africa (but not in sera from patients infected with other filarial parasites or intestinal nematodes), suggesting its diagnostic potential.Carolyn A. Brown KW - antigens KW - complementary DNA KW - Filariids KW - helminths KW - Human diseases KW - molecular genetics KW - parasites KW - Nematoda KW - Onchocerca volvulus KW - invertebrates KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - antigenicity KW - biochemical genetics KW - cDNA KW - immunodominant KW - immunogens KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862717&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombinant DNA probes reveal simultaneous infection of tsetse flies with different trypanosome species. AU - Majiwa, P. A. O. AU - Otieno, L. H. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1990/// VL - 40 IS - 2 SP - 245 EP - 253 SN - 0166-6851 AD - Majiwa, P. A. O.: National Cancer Institute, Frederick Cancer Research Facility, Bld. 539, PO Box B, Frederick, MD 21701, USA. N1 - Accession Number: 19900863911. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The utility of recombinant DNA probes in the detection of natural trypanosome infection of tsetse flies was assessed in Lambwe Valley, near the shores of Lake Victoria, Kenya. The tsetse flies were surveyed during 2 different seasons in 1988. Three different probes used each contained highly repetitive DNA sequences specific for a species or subspecies of trypanosomes of the Nanomonas subgenus. A 4th probe contained repetitive sequences common to trypanosome species of the Trypanozoon subgenus. Mixed mature or immature infections were detected in a variety of combinations in different individual tsetse flies. Such infections were detected in both the guts and mouthparts of some tsetse flies. Simultaneous natural infection of tsetse with the savannah type Trypanosoma congolense and Kilifi type T. congolense, T. congolense and T. brucei or T. congolense and T. simiae were demonstrated. The probes were thus used to demonstrate the presence in Lambwe Valley of a type of T. congolense first observed among trypanosome isolates obtained from sentinel cattle exposed to natural infection on a ranch at Kilifi on the Kenya coast. This type of T. congolense appears not to be confined to the coastal region nor to any particular species of tsetse flies and may contribute significantly to livestock morbidity in other areas of eastern Africa. In the Kilifi area, T. congolense was found primarily in Glossina austeni; in Lambwe Valley, it was found in G. pallidipes. KW - chemotaxonomy KW - detection KW - disease vectors KW - DNA probes KW - Infections KW - Intermediate hosts KW - mixed infections KW - parasites KW - techniques KW - Vectors KW - Africa KW - Kenya KW - Diptera KW - Glossina KW - Glossina austeni KW - Glossina pallidipes KW - Glossinidae KW - Insects KW - protozoa KW - Sarcomastigophora KW - Trypanosoma KW - Trypanosoma brucei KW - Trypanosoma congolense KW - Trypanosoma simiae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Glossinidae KW - Diptera KW - Glossina KW - Protozoa KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Trypanosoma KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - East Africa KW - Africa South of Sahara KW - biochemical taxonomy KW - multiple infections KW - secondary hosts KW - Taxonomy and Evolution (ZZ380) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863911&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variant specific epitopes of Giardia lamblia. AU - Nash, T. E. AU - Conrad, J. T. AU - Merritt, J. W., Jr. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1990/// VL - 42 IS - 1 SP - 125 EP - 132 SN - 0166-6851 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869867. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The capability of G. lamblia to express certain epitopes on the surfaces of trophozoites from different isolates and clones was determined using 4 surface-reacting monoclonal antibodies (MAbs) to variants derived from WB or WB-like Giardia (MAbs 6E7, 5C1, and 3F6) and GS/M (MAb G10/4). Of 28 isolates, 11 possessed trophozoites reactive with MAbs 6E7, 5C1 and 3F6, 6 with MAb 3F6, 2 with MAb G10/4, 1 with MAb 6E7, and 8 showed no reactivity as determined by direct or indirect immunofluorescence. Newly established clones from different isolates generated small numbers of reactive trophozoites similar to their parents. Only one epitope was found on any single trophozoite. Southern blots hybridized to a probe encoding for the epitope recognized by MAb 6E7 revealed that the inability to express the antigen in most isolates was due to lack of the gene. Analysis of the surface antigens of MAb 6E7 reactive clones from 3 isolates revealed that MAb 6E7 reacted with surface antigens of different molecular masses.<new para>ADDITIONAL ABSTRACT:<new para>The authors report that among Giardia variant surface antigens the range of epitopes expressed is limited but that the same epitope may be expressed in proteins of different sizes. For example, one defined epitope was expressed in proteins of Mr 73 000, 115 000 and 120 000 in clones from a single isolate. By use of a DNA probe it was shown that a clone not expressing an epitope lacked the gene for that antigen.Further work is clearly needed and is proceeding to examine these changes and to determine their significance in relation to the role of the organism as an intestinal pathogen.S.G. Wright KW - antigenic variation KW - antigens KW - epitopes KW - Human diseases KW - Monoclonal antibodies KW - parasites KW - surface antigens KW - Giardia duodenalis KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic determinants KW - antigenic polymorphism KW - antigenicity KW - Giardia lamblia KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869867&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Discovery and disease control. AU - Miller, L. H. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1990/// VL - 42 IS - 3 SP - 191 EP - 195 SN - 0002-9637 AD - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864934. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The importance of basic research, despite the fact that it may not lead to immediate solutions of major health problems, is illustrated by past successes in malaria control. The critical events that led to the discovery of antimalarials such as chloroquine, successes in mosquito control, and vaccine research are described. The need for a balanced programme of basic research, applied research and training in the USA is discussed. KW - Antimalarials KW - Antiprotozoal agents KW - chemical control KW - control KW - disease vectors KW - Human diseases KW - Insecticides KW - Malaria KW - Mosquito-borne diseases KW - parasites KW - research KW - Vaccines KW - Vectors KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - Insects KW - Invertebrates KW - man KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - discussion KW - mosquitoes KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) KW - Research (AA500) KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864934&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombinant capsular antigen (Fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice. AU - Simpson, W. J. AU - Thomas, R. E. AU - Schwan, T. G. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1990/// VL - 43 IS - 4 SP - 389 EP - 396 SN - 0002-9637 AD - Simpson, W. J.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19910504715. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - Yersinia pestis produces a glycoprotein capsule, the biosynthesis of which appears to be temperature dependent. The fraction I (F1) component of this capsule is specific to Y. pestis and the detection of F1 antibodies is the basis for several serological tests. The cloning of the F1 gene and its expression in Escherichia coli using the phagemid vector λZAPII and a F1-specific monoclonal antibody are reported. The recombinant F1 antigen had a molecular weight of 17 kDa, which proved to be identical to that of the F1 antigen produced by Y. pestis. The recombinant cells produced F1 antigen at 37°C but only minimal amounts at 27°C, suggesting that the genetic features affected by temperature in Y. pestis may be operating in the E. coli clone. It is not known if their similar molecular weights reflect the glycosylated nature of both proteins. F1 antigen purified from the E. coli recombinant induced a protective immune response in BALB/c mice challenged with up to 105 virulent Y. pestis. The resistance of immunized mice to plague infection correlated with high titres of F1 antibody. The cloned gene expresses an immunogenically competent F1 antigen suitable for use in plague serodiagnostics and vaccine development. KW - Antibodies KW - antigens KW - Bacterial diseases KW - Biotechnology KW - Clones KW - Gene expression KW - Genes KW - Glycoproteins KW - immune response KW - immunization KW - Immunodiagnosis KW - Plague KW - Vaccines KW - mice KW - Yersinia pestis KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterial infections KW - bacterioses KW - bacterium KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - recombinant capsular antigen KW - serological diagnosis KW - YERSINIA PSEUDOTUBERCULOSIS SUBSP. PESTIS KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504715&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body mass index and 15-year mortality in a cohort of black men and women. AU - Weinpahl, J. AU - Ragland, D. R. AU - Sidney, S. JO - Journal of Clinical Epidemiology JF - Journal of Clinical Epidemiology Y1 - 1990/// VL - 43 IS - 9 SP - 949 EP - 960 SN - 0895-4356 AD - Weinpahl, J.: National Institute on Aging, Epidemiology, Demography and Biometry Program, Federal Building, Room 618, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19911433285. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition N2 - The association between body mass index (BMI) and mortality was studied in 2453 black men, 30 to 79 years old, and 2731 black women, 40 to 79 years old, in California, USA, all members of the Kaiser Foundation Health Plan, a pre-paid health maintenance organization. During a 15-year follow-up 393 men and 283 women died. Separate effects of low weight and high weight on mortality were isolated. Potential bias from cigarette smoking and antecedent illness was noted. Cox regression analyses showed that over the entire range of BMI the adjusted BMI-mortality association was significantly J-shaped for men and flat for women. The inverse association between BMI and mortality in the lower range of BMI was significant for men; the adjusted relative hazard increasing from the 10th to the 50th percentile of BMI was 0.76 (95% confidence interval (CI) 0.59 to 0.98). The positive association between BMI and mortality in the upper range of BMI was highly significant for men; the adjusted relative hazard increasing from the 50th to the 90th percentile of BMI was 1.37 (95% CI 1.14 to 1.63). Smoking and antecedent illness did not have an impact on the BMI-mortality association in either sex. KW - body measurements KW - Ethnic groups KW - mortality KW - California KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - death rate KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433285&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Validation of a self-administered diet history questionnaire using multiple diet records. AU - Block, G. AU - Woods, M. AU - Potosky, A. AU - Clifford, C. JO - Journal of Clinical Epidemiology JF - Journal of Clinical Epidemiology Y1 - 1990/// VL - 43 IS - 12 SP - 1327 EP - 1335 SN - 0895-4356 AD - Block, G.: National Cancer Institute, Executive Plaza North, Room 313, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19911433291. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - The validity of a self-administered diet history questionnaire was estimated using as reference data the mean of 3 4-day diet records collected during the year before the questionnaire was given in 1985-86. Subjects were 260 women, 45 to 70 years old, who participated in the Women's Health Trial Feasibility Study, a multi-centre clinical trial in the USA, in which some women took a diet low in fat and others maintained their normal diet. The questionnaire produced group mean nutrient estimates close to values obtained by 4-day records, e.g. in those on normal diet, 37.7% of energy from fat by food records and questionnaire and in the low-fat group, 21.3% of energy from fat by food records and 23.7% of energy from fat by questionnaire. Correlations between questionnaire and diet records for percentage of energy were 0.67 and 0.65, respectively, in the 2 groups. Most correlations were in the range 0.5 to 0.6 and were similar to that achieved by a single 4-day food record. KW - Diet study techniques KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433291&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The generation of genetic diversity in malaria parasites. AU - McConkey, G. A. AU - Waters, A. P. AU - McCutchan, T. F. JO - Annual Review of Microbiology JF - Annual Review of Microbiology Y1 - 1990/// VL - 44 SP - 479 EP - 498 SN - 0066-4227 AD - McConkey, G. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920883148. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Protozoology N2 - This review focuses on the generation of diversity in Plasmodium falciparum and its implications with regard to the parasite's potential for dealing with variables in its environment such as immune and drug pressure. Major headings include: the P. falciparum chromosome ; chromosomal polymorphism ; gene duplication; repetitive sequences in the surface antigen genes; point mutations and selection; parasites under pressure. KW - antigens KW - chromosomes KW - evolution KW - genetic variation KW - malaria KW - parasites KW - polymorphism KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - genetic variability KW - genotypic variability KW - genotypic variation KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920883148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Age- and sex-dependent stimulation of calcium uptake in duodenal cells by prolactin in vitamin D-deficient rats. AU - Balakir, R. A. AU - Cheng, L. AU - Sacktor, B. AU - Liang, C. T. JO - Life Sciences JF - Life Sciences Y1 - 1990/// VL - 47 IS - 1 SP - 77 EP - 83 SN - 0024-3205 AD - Balakir, R. A.: C. T. Liang, Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19921448183. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 7440-70-2, 9002-62-4, 1406-16-2. Subject Subsets: Human Nutrition N2 - Administration of ovine-prolactin (O-PRL) stimulated Ca2+ uptake in isolated duodenal cells prepared from vitamin D-deficient rats. The time course of this effect was biphasic: uptake activity reached a peak in 2.5 h followed by a decrease at 5 h to original values. This stimulatory effect of O-PRL was observed in vitamin D-deficient male, but not in female rats. This stimulatory effect was observed in rats 16 and 26 but not 9 weeks old. Increase in Ca2+ uptake in duodenal cells was not due to a decrease in intracellular Ca2+ efflux. Serum calcium increased in deficient female rats between 16 and 52 weeks whereas a minimal increase was observed in deficient male rats. Although prolactin was shown to stimulate duodenal Ca2+ uptake, it seems that the source of the increase in serum Ca in deficient female rats was not derived from an increase in Ca2+ uptake by prolactin in duodenum. The increase in serum Ca with time may explain why female vitamin D-deficient rats survive longer than male. KW - calcium KW - deficiency KW - duodenum KW - prolactin KW - uptake KW - Vitamin D KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - lactogenic hormone KW - mammotropin KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448183&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin A prophylaxis programs in developing countries: past experiences and future prospects. AU - Underwood, B. A. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1990/// VL - 48 IS - 7 SP - 265 EP - 274 SN - 0029-6643 AD - Underwood, B. A.: International Program Activities, National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19901451726. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 68-26-8. Subject Subsets: Horticultural Science; Human Nutrition; Tropical Diseases N2 - Clinical eye signs are estimated to affect 5 to 10 million children annually in the developing world. Thus, most experience with large-scale prophylaxis programmes has been with periodic distribution of high-dose vitamin A supplements directed toward preventing ocular problems. However, subclinical vitamin A depletion affects an estimated five- to tenfold larger population, and evidence is accumulating for a subclinical protective role of vitamin A against risk of mortality and, perhaps, morbidity. Current programmes aim to integrate prophylaxis with vitamin A supplements into ongoing programmes. Decentralization of distribution of supplements and their integration into community-based programmes require careful consideration of dosages and frequency to assure safety and broad coverage. Fortification of foods and condiments has not provided adequate prophylaxis in countries with significant vitamin A deficiency. Other strategies recognized as more sustainable, long-term solutions have received less attention, and their potential has not been evaluated. Such strategies aim to increase dietary intake of vitamin A or decrease physiological requirements or both: these strategies include horticulture, public health, socioeconomic improvement and nutrition and health education measures. KW - children KW - deficiency KW - eye diseases KW - nutrition KW - prophylaxis KW - Retinol KW - supplements KW - vitamins KW - Developing countries KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - countries KW - A KW - axerophthol KW - supplementation programmes KW - Third World KW - Underdeveloped Countries KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451726&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum vitamin A and subsequent development of prostate cancer in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. AU - Reichman, M. E. AU - Hayes, R. B. AU - Ziegler, R. G. AU - Schatzkin, A. AU - Taylor, P. R. AU - Kahle, L. L. AU - Fraumeni, J. F., Jr. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1990/// VL - 50 IS - 8 SP - 2311 EP - 2315 SN - 0008-5472 AD - Reichman, M. E.: National Cancer Institute, NIH, 9000 Rockville Pike, EPN 211, Bethesda, MD 20892, USA. N1 - Accession Number: 19931453824. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - The relation between serum vitamin A measurements made at baseline examination (1971-75) and subsequent development of prostate cancer was examined in the USA, National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (1981-1984). The analytic cohort consisted of 2440 men 50 years old or older who were followed for a median of 10 years. A total of 84 men developed prostate cancer. The mean level of serum vitamin A was significantly lower in prostate cancer than in controls. As a continuous variable or in quartiles, a significant trend was observed for increased risk of prostate cancer with decreasing serum vitamin A. Adjusted for age and race, men in the lowest quartile had a relative risk of 2.2 (95% confidence intervals 1.1, 4.3) compared with those in the highest quartile. The increased risk of prostate cancer associated with the lowest quartile of serum vitamin A did not attenuate with increasing time between blood drawing and diagnosis, suggesting that metabolic effects of early disease are an unlikely explanation of these results. The inverse association between serum vitamin A and prostate cancer incidence was independent of age at examination and several other possible confounding variables. KW - Blood KW - Carcinoma KW - Prostate KW - Retinol KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931453824&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A case-control study of diet and benign proliferative epithelial disorders of the breast. AU - Rohan, T. E. AU - Cook, M. G. AU - Potter, J. D. AU - McMichael, A. J. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1990/// VL - 50 IS - 11 SP - 3176 EP - 3181 SN - 0008-5472 AD - Rohan, T. E.: National Cancer Institute of Canada Epidemiology Unit, McMurrich Building, 3rd Floor, University of Toronto, Toronto, Ont. M5S 1A8, Canada. N1 - Accession Number: 19911453938. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - Benign proliferative epithelial disorders (BPED) of the breast are conditions which, although not proven precursors of breast cancer, are strongly associated with increased risk of this disease. In a case-control study in Adelaide, South Australia, the association between dietary factors and risk of BPED was investigated. The study involved 383 cases of biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation and 383 unbiopsied community controls matched to cases on age and area of residence. When cases were compared with community controls, there was little variation in the risk of BPED across amounts of daily intake of energy, protein and fat, but there was some suggestion of inverse associations with daily intake of retinol, β-carotene and fibre; in contrast, with biopsy controls as the comparison group, risk of BPED increased with increasing energy and fat intake but varied little with retinol, βcarotene and fibre intake. Results provide additional evidence against roles for dietary energy and fat intake in the aetiology of breast cancer. However, further studies of diet and BPED should be conducted in populations surveyed cross-sectionally for breast changes, in an attempt to limit or avoid the selection and misclassification biases to which studies of putative precursor lesions are susceptible. KW - Carcinoma KW - diets KW - mammary glands KW - Australia KW - South Australia KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - Australia KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453938&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Undernutrition among Bedouin Arab infants: the Bedouin Infant Feeding Study. AU - Forman, M. R. AU - Guptill, K. S. AU - Chang, D. N. AU - Sarov, B. AU - Berendes, H. W. AU - Naggan, L. AU - Hundt, G. L. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1990/// VL - 51 IS - 3 SP - 343 EP - 349 SN - 0002-9165 AD - Forman, M. R.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, 6130 Executive Plaza North Room 211, Rockville, MD 20892, USA. N1 - Accession Number: 19901425707. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition; Tropical Diseases N2 - In 1981, 274 healthy newborn Bedouin Arab infants in the Negev, Israel, were followed for 18 months to examine the relation between infant-feeding practices and growth during planned social change. Although wasting was not prevalent, the prevalence rate of stunting (≤-2 s.d.) increased from 12 to 19 to 32% at 6, 12 and 18 months, respectively. After multiple-logistic-regression adjustment for covariates, the odds ratio (OR) of stunting at 6 months was reduced among infants breast-fed only or fed with supplement compared with weaned infants. Infant-feeding practices were not associated with stunting in later infancy; those stunted at 6 months had an OR of 13 of stunting at 12 months and those stunted at 12 months had an OR of 14 of stunting at 18 months. In a multiple-linear-regression analysis, seasonality, duration of breast-feeding, hospitalized morbidity and residual of height at 6 months were negatively associated with daily average linear growth from 6 to 12 months; these factors only explained 12% of the variation in daily linear growth.<new para>ADDITIONAL ABSTRACT:<new para>Two hundred seventy-four healthy Bedouin Arab newborns in 1981 were followed for 18 mo to examine the relationship between infant-feeding practices and growth during planned social change. Although wasting was not prevalent, the prevalence rate of stunting (≤-2 SDs) increased from 12% to 19% to 32% at 6, 12, and 18 mo, respectively. After multiple-logistic-regression adjustment for covariates, the odds ratio (OR) of stunting at 6 mo was reduced among infants breast-fed only or fed with supplement compared with weaned infants. Infant-feeding practices were not associated with stunting in later infancy; however, those stunted at 6 mo had an OR of 13 of stunting at 12 mo and those stunted at 12 mo had an OR of 14 of stunting at 18 mo. In a multiple-linear-regression analysis, seasonality, duration of breast-feeding, hospitalized morbidity, and residual of height at 6 mo were negatively associated with daily average linear growth from 6 to 12 mo; these factors only explained 12% of the variation in daily linear growth.AS KW - children KW - ethnic groups KW - feeding KW - growth KW - Infants KW - Nutrition KW - nutritional state KW - Asia KW - Israel KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - Mediterranean Region KW - Middle East KW - West Asia KW - Asia KW - Bedouin KW - nutritional status KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901425707&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary vitamin B-6 intake and food sources in the US population: NHANES II, 1976-1980. AU - Kant, A. K. AU - Block, G. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1990/// VL - 52 IS - 4 SP - 707 EP - 716 SN - 0002-9165 AD - Kant, A. K.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19911428782. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 65-23-6. Subject Subsets: Human Nutrition; Potatoes N2 - Dietary vitamin B6 intake and food sources were estimated from the Second National Health and Nutrition Examination Survey (NHANES II) dietary data for 11658 adults 19 to 74 years old in the USA. The average daily intake of vitamin B6 was 1.48±0.01 mg (mean±s.e.m.) for the total population, 1.85±0.02 for men and 1.14±0.01 for women. Of men 71 and women 90% consumed less than the 1980 recommended dietary allowance (RDA) of vitamin B6. Of all survey respondents 64% reported a ratio of vitamin B6 to dietary protein of <0.02 (expressed as mg/g protein). Foods from animal and plant sources provided 48 and 52% of the total vitamin B6, respectively. Vitamin B6 intake decreased with increasing age and decreasing education and income status. Beef steaks and roasts, alcoholic beverages, potatoes, ready-to-eat cereals and milk were important dietary sources of vitamin B6. KW - intake KW - Nutrition KW - Pyridoxine KW - sources KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911428782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A. AU - Potischman, N. AU - McCulloch, C. E. AU - Byers, T. AU - Nemoto, T. AU - Stubbe, N. AU - Milch, R. AU - Parker, R. AU - Rasmussen, K. M. AU - Root, M. AU - Graham, S. AU - Campbell, T. C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1990/// VL - 52 IS - 5 SP - 909 EP - 915 SN - 0002-9165 AD - Potischman, N.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429887. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - A case-control study of breast cancer was made in Buffalo, New York, USA. Participants completed a food frequency questionnaire and donated a fasting blood sample before definitive workup for breast masses. Dietary and plasma concentrations of carotenoids and retinol for 83 women found to have breast cancer were compared with those of 113 women free of breast cancer (control subjects). There were no case-control differences in dietary estimates of retinol intake or in plasma α-carotene and lycopene. However, subjects with breast cancer had lower concentrations of plasma β-carotene than did controls (P = 0.02). There was no overall association between plasma retinol and breast cancer but a positive relation was observed between retinol and breast cancer in the subgroup with low β-carotene values. These results suggest that low plasma β-carotene is associated with increased risk of breast cancer. Other studies will need to determine whether low carotene concentrations are a subtle effect of the disease or might be causally related to breast cancer. KW - blood KW - Carcinoma KW - carotenoids KW - diets KW - mammary glands KW - retinol KW - New York KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - tetraterpenoids KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429887&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Novel dialkylpiperidines in the venom of the ant Monomorium delagoense. AU - Jones, T. H. AU - Blum, M. S. AU - Robertson, H. G. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1990/// VL - 53 IS - 2 SP - 429 EP - 435 SN - 0163-3864 AD - Jones, T. H.: Laboratory of Chemistry, National Heart, Lung and Blood Institute, Betheseda, MD 20892, USA. N1 - Accession Number: 19920512685. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - New dialkylpiperidines, including cis- and trans-2,6-di(4-pentenyl)-piperidine, cis- and trans-2-(4-pentenyl)-6-pentylpiperidine, and cis- and trans-2-(6-heptenyl)-6-(4-pentenyl)-piperidine were detected in the venom of the southern African ant M. delagoense by gas chromatography/mass spectrometry. The structures of these compounds (which were shown to possess insecticidal and repellent properties) were confirmed by synthesis. KW - biochemistry KW - Insecticidal properties KW - Molecular conformation KW - Piperidines KW - Repellency KW - Toxins KW - venoms KW - Formicidae KW - Hymenoptera KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Monomorium KW - Formicidae KW - Monomorium delagoense KW - Social insecs KW - Toxinology KW - venom KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920512685&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus. AU - Beutler, J. A. AU - Alvarado, A. B. AU - Schaufelberger, D. E. AU - Andrews, P. AU - McCloud, T. G. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1990/// VL - 53 IS - 4 SP - 867 EP - 874 SN - 0163-3864 AD - Beutler, J. A.: Developmental Therapeutics Program, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA. N1 - Accession Number: 19900399736. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Horticultural Science N2 - The phorbol dibutyrate receptor binding assay is used to identify organisms containing bioactive substances. The process of rapidly identifying known chemotypes is termed dereplication in the antibiotics field. C. cuneatus leaves and the marine blue-green alga L. majuscula were used as prototypes for the dereplication of phorbol ester receptor binding activity. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in Croton. KW - composition KW - medicinal plants KW - Croton KW - Euphorbiaceae KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lyngbya KW - Cyanobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - Croton cuneatus KW - drug plants KW - Lyngbya majuscula KW - medicinal herbs KW - officinal plants KW - plant KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900399736&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. AU - Vishwanath, S. AU - McDonald, G. A. AU - Watkins, N. G. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 3 SP - 646 EP - 653 SN - 0019-9567 AD - Vishwanath, S.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515396. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - There are no vaccines against boutonneuse fever or Rocky Mountain spotted fever. Previous studies identified a R. rickettsii surface protein as a vaccine candidate and showed that an antigenically related protein is present in R. conorii. The gene encoding the R. rickettsii protein was cloned and expressed in Escherichia coli. By using 7.5% SDS-PAGE of rickettsial lysates followed by immunoblotting with a monoclonal antibody raised against the R. rickettsii protein it was confirmed that an analogous protein exists in R. conorii. Although these proteins were previously called 155-kDa proteins, their apparent molecular masses were 198 kDa for R. conorii Kenya tick typhus (KTT) and 190 kDa for R. rickettsii. Using the R. rickettsii gene probe, a 5.5-kb HindIII fragment from R. conorii KTT genomic DNA was cloned and expressed in E. coli JM107. The expressed recombinant product was recognized by a monospecific polyclonal rabbit antiserum prepared against the 198-kDa protein. Guineapigs immunized with sonic lysates of the E. coli strain expressing the recombinant gene product developed antibodies recognizing R. conorii when tested by a microimmunofluorescence antibody assay. Upon immunoblotting of rickettsial lysates, those antisera specifically recognized the 198-kDa R. conorii protein and its 190-kDa analogue in R. rickettsii. Guineapigs immunized with sonic lysates of the recombinant E. coli expressing the 198-kDa protein were protected from experimental infections with the homologous R. conorii strain and partially protected from experimental infections with a strain of the heterologous species R. rickettsii. These findings show that the 198-kDa R. conorii protein is a candidate for a vaccine against boutonneuse fever. KW - DNA KW - Genes KW - immunization KW - Laboratory animals KW - Recombinant vaccines KW - Rickettsial diseases KW - vaccines KW - Escherichia coli KW - guineapigs KW - Rickettsia conorii KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - bacterium KW - Cloning KW - deoxyribonucleic acid KW - E. coli KW - guinea pigs KW - immune sensitization KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Borrelia burgdorferi contains repeated DNA sequences that are species specific and plasmid associated. AU - Simpson, W. J. AU - Garon, C. F. AU - Schwan, T. G. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 4 SP - 847 EP - 853 SN - 0019-9567 AD - Simpson, W. J.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515476. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi contains linear and supercoiled circular (SC) plasmids. Because SC plasmids are present in multiple copies, these plasmids were examined for species-specific sequences that could serve as high-copy-number target DNAs for a diagnostic probe. 3 EcoRI fragments (4.3, 4.2 and 3.5 kb pairs) that hybridized with multiple DNA fragments from B. burgdorferi were identified and cloned from a SC plasmid-enriched fraction. The 4.2- and 3.5-kb fragments were similar in that they hybridized with each other and with similar-sized EcoRI fragments from 2 unrelated strains of B. burgdorferi. The 4.3-kb fragment did not hybridize with the other 2 cloned sequences. Both types of sequences hybridized with most of the SC plasmids in 7 B. burgdorferi isolates, whereas only a single 49-kb linear plasmid, found in 2 of the 7 strains tested, hybridized with the cloned sequences. None of the cloned sequences hybridized with chromosomal DNA from B. burgdorferi or with total DNA or SC plasmids from Borrelia hermsii, B. turicatae, B. coriaceae, B. parkeri or B. anserina. These data indicate that the repeated DNA sequences described in this study appear to be plasmid associated and specific to B. burgdorferi. Heteroduplexes formed from the 4.2- and 3.5-kb fragments showed that hybridizing regions in each fragment comprise a 1.8-kb conserved region that is adjacent to a 1.5-kb region that exhibits greater sequence variability. The sequence divergence seen in the variable region is likely the result of genetic drift and may mean that these regions represent closely related genes that encode functionally similar but antigenically distinct proteins. KW - DNA KW - DNA hybridization KW - DNA probes KW - Genes KW - molecular genetics KW - Nucleotide sequences KW - Plasmids KW - Borrelia anserina KW - Borrelia burgdorferi KW - Borrelia coriaceae KW - Borrelia hermsii KW - Borrelia parkeri KW - Borrelia turicatae KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - Repeat DNA KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515476&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease. AU - Gazzinelli, R. T. AU - Leme, V. M. C. AU - Cançado, J. R. AU - Gazzinelli, G. AU - Scharfstein, J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 5 SP - 1437 EP - 1444 SN - 0019-9567 AD - Gazzinelli, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871966. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - T. cruzi antigenic specificities involved in human T-cell and antibody responses were compared in chronic chagasic patients affected with cardiomyopathy (C) or with the indeterminate form (I), the asymptomatic form of Chagas' disease. T-cell Western blotting (immunoblotting) was performed to identify the most active antigens in epimastigote extracts (EPI-Ag). The patterns of peripheral blood mononuclear cell (PBMC) and T-cell proliferative responses induced by fractions blotted to nitrocellulose were heterogeneous, but the computation of their frequency distribution disclosed some important antigen specificities. Molecules ranging from 100 000, 150 000 MW were frequently stimulatory to PBMC from I patients (5 of 8 cases) and were less so when confronted with C patient (1 of 7 cases) lymphocytes. In contrast, both groups of patients actively responded to fractions ranging from 48 000 to 57 000 and 28 000 to 32 000 MW. The Western immunoblotting patterns of antibody reactivity displayed by 17 C and 15 I patients were also similar, yielding outstanding staining in the MW ranges of 70 000 to 80 000 and 43 000 to 57 000 MW. The latter antigen complex was recognized by 100% of the 32 chronic Chagas' disease serum specimens tested and closely corresponded to the migratory position recognized by T cells of most patients tested. The identification of the active molecules contained in the 43 000 to 57 000 MW region was sought, with a focus on GP57/51, an antigen with well-established serodiagnostic properties. Immunoblotting analysis of EPI-Ag with a monoclonal antibody to GP57/51 confirmed its presence within the predicted MW region. Highly purified GP51 was then used to demonstrate directly its capacity to promote specific PBMC proliferative responses in vitro. Data computed from a survey with 12 patients showed a linear correlation (r = 0.93) between PBMC responses to EPI-Ag and to purified GP51, suggesting that the immune response to this particular glycoprotein may be an important component of human immune responses against T. cruzi. KW - antibodies KW - antigens KW - Chagas' disease KW - glycoproteins KW - Human diseases KW - immune response KW - immunity KW - parasites KW - responses KW - T lymphocytes KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871966&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of Pneumocystis carinii chromosomes and mapping of five genes. AU - Lundgren, C. AU - Cotton, R. AU - Lundgren, J. D. AU - Edman, J. C. AU - Kovacs, J. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 6 SP - 1705 EP - 1710 SN - 0019-9567 AD - Lundgren, C.: J. A. Kovacs, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872282. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology N2 - Pulsed field gel electrophoresis was used to identify the chromosome-size DNA of P. carinii. Thirteen chromosomes of rodent P. carinii, ranging in size from 300 to 700 kilobases (kb), were identified. The minimum genome size for P. carinii, estimated on the basis of the sizes of chromosomes, is 7000 kb. Genetic heterogeneity among different P. carinii isolates was documented by demonstration of chromosomal size variability. By hybridization studies, the genes for topoisomerase I, dihydrofolate reductase, rRNA, actin, and thymidylate synthase were mapped to single chromosomes of approximately 650, 590, 550, 460, and 350 kb, respectively. Hybridization studies further confirmed the genetic heterogeneity of P. carinii. KW - chromosomes KW - Human diseases KW - molecular genetics KW - parasites KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Rodents KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - mammals KW - vertebrates KW - Chordata KW - biochemical genetics KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872282&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Galβ1-4Glcβ1-1Cer), a possible adhesion receptor for yeasts. AU - Jimenez-Lucho, V. AU - Ginsburg, V. AU - Krivan, H. C. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 7 SP - 2085 EP - 2090 SN - 0019-9567 AD - Jimenez-Lucho, V.: H. C. Krivan, Laboratory of Structural Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901206594. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The role of glycosphingolipids as adhesion receptors for yeasts was examined. Cryptococcus neoformans, Candida albicans and Saccharomyces cerevisiae, as well as Histoplasma capsulatum and Sporotrichum [Sporothrix] schenckii (in their yeast phases), bound specifically to lactosylceramide (Galβ1-4Glcβ1-1Cer), as measured by overlaying glycosphingolipid chromatograms with 125I-labelled organisms. An unsubstituted galactosyl residue was required for binding, because the yeasts did not bind to glucosylceramide (G1cβ1-1Cer) derived from lactosylceramide by treatment with β-galactosidase or to other neutral or acidic glycosphingolipids tested that contained internal lactosyl residues. The yeasts preferentially bound to the upper band of the lactosylceramide doublet in human lung and bovine erythrocytes, indicating that the ceramide structure also affects binding. Active metabolism of the yeasts was required for binding to lactosylceramide, as binding was maximal in buffer containing glucose and was almost completely abolished in nutrient-deficient medium. Cryptococcus neoformans also bound to human glioma brain cells grown in monolayers and this binding was inhibited by liposomes containing lactosylceramide but not by liposomes containing glucosylceramide. Lactosylceramide is a major glycosphingolipid in these cells and the only one to which the yeasts bound. It is concluded that since lactosylceramide is widely distributed in epithelial tissues, this glycosphingolipid may be the receptor for yeast colonization and disseminated disease in humans. KW - adhesion KW - Candida albicans KW - Cryptococcus neoformans KW - Histoplasma capsulatum KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Sporothrix schenckii KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Saccharomyces KW - Saccharomycetaceae KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Ajellomyces capsulatus KW - fungus KW - Hyphomycetes KW - lactosylceramide KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206594&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that Candida stellatoidea type II is a mutant of Candida albicans that does not express sucrose-inhibitable α-glucosidase. AU - Kwon-Chung, K. J. AU - Hicks, J. B. AU - Lipke, P. N. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 9 SP - 2804 EP - 2808 SN - 0019-9567 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19901207059. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9001-42-7. Subject Subsets: Medical & Veterinary Mycology N2 - It was shown that sucrose-positive revertants of C. stellatoidea type II are readily isolated and that C. stellatoidea type II strs. probably resulted from a mutation of the sucrase gene of C. albicans. The revertants were not laboratory contaminants, as determined by restriction fragment length polymorphism analysis and retention of an auxotrophic marker. The reversion of 3 tested strs. was accompanied by 16- to 110-fold increases in expression of a sucrase/α-glucosidase but not an invertase, with a Kmfor sucrose of about 1 mM. The enzyme activity was assayable in intact cells. It is suggested that the drastically increased expression of such an enzyme would allow extracellular sucrose hydrolysis and assimilation of the monosaccharide products. KW - alpha-glucosidase KW - enzymes KW - genetics KW - mutants KW - physiology KW - taxonomy KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - alpha-D-glucosidase KW - Candida stellatoidea KW - fungus KW - Hyphomycetes KW - maltase KW - systematics KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207059&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunization of mice against Plasmodium vinckei with a combination of attenuated Salmonella typhimurium and malarial antigen. AU - Kumar, S. AU - Gorden, J. AU - Flynn, J. L. AU - Berzofsky, J. A. AU - Miller, L. H. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 10 SP - 3425 EP - 3429 SN - 0019-9567 AD - Kumar, S.: L.H. Miller, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871559. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology N2 - Infection with the blood stage of P. vinckei is uniformly lethal in mice. It was found that immunization of BALB/c mice with a combination of killed P. vinckei antigens and an attenuated (aroA) S. typhimurium strain induced high levels of protection against challenge with live P. vinckei. This is especially significant because, in previous studies, immunization of mice with killed P. vinckei antigens and adjuvants such as Bordetella pertussis, complete Freund adjuvant, and saponin failed to induce protective immunity. Immunization with attenuated S. typhimurium alone did not provide any nonspecific immunity. In vivo depletion of CD4+ T cells in the mice immunized with attenuated S. typhimurium and P. vinckei antigens caused the loss of their immunity. Expression of this immunity required the presence of a spleen. These results support a previous hypothesis that a blood stage malaria vaccine may need both induction of CD4+ T cells specific for the parasite and modification of the spleen with a vaccine vehicle. Therefore, attenuated Salmonella strains such as the one used in this study, when expressing recombinant malarial antigens, might fulfill this requirement. KW - combined vaccines KW - Human diseases KW - immunization KW - Laboratory animals KW - parasites KW - Spleen KW - T lymphocytes KW - Vaccines KW - Apicomplexa KW - mice KW - Plasmodium vinckei KW - protozoa KW - Rodents KW - Salmonella typhimurium KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - immune sensitization KW - mixed vaccines KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871559&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a monoclonal antibody that selectively recognizes a subset of Entamoeba histolytica isolates. AU - Bhattacharya, A. AU - Ghildyal, R. AU - Bhattacharya, S. AU - Diamond, L. S. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1990/// VL - 58 IS - 10 SP - 3458 EP - 3461 SN - 0019-9567 AD - Bhattacharya, A.: L.S. Diamond, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871560. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology N2 - An MAb (2D7.10) recognized an antigen present in 7 of 9 isolates of axenically cultured E. histolytica and absent in all other Entamoeba isolates studied. The antigen was absent in 2 isolates: 200:NIH and Rahman. All 9 isolates belonged to pathogenic zymodeme II. Western blot (immunoblot) analysis and treatment with periodate and the proteolytic enzyme trypsin suggest that the antigen recognized by 2D7.10 is a carbohydrate moiety. KW - antigens KW - Human diseases KW - Immunotaxonomy KW - monoclonal antibodies KW - parasites KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871560&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selenium biochemistry. AU - Stadtman, T. C. JO - Annual Review of Biochemistry JF - Annual Review of Biochemistry Y1 - 1990/// VL - 59 SP - 111 EP - 127 SN - 0066-4154 AD - Stadtman, T. C.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921445012. Publication Type: Journal Article. Language: English. Number of References: 97 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - Developments in selenium biochemistry since 1980 are reviewed. The main topics considered are (1) selenoenzymes that contain selenocysteine (bacterial enzymes apart from mammalian glutathione peroxidase), (2) mammalian selenoproteins, (3) bacterial selenoenzymes that do not contain selenocysteine, (4) seleno-tRNAs and (5) incorporation of selenocysteine into proteins in prokaryotes and eukaryotes. Consideration is also given to some additional aspects of selenium containing enzymes and other compounds in prokaryotes. KW - biochemistry KW - reviews KW - Selenium KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445012&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites. AU - Adams, J. H. AU - Hudson, D. E. AU - Torii, M. AU - Ward, G. E. AU - Wellems, T. E. AU - Aikawa, M. AU - Miller, L. H. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1990/// VL - 63 IS - 1 SP - 141 EP - 153 SN - 0092-8674 AD - Adams, J. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874336. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology N2 - P. vivax and P. knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. A soluble parasite protein of 135 000 MW binds specifically to a human Duffy antigen. Using antisera affinity purified on the 135 000 MW protein, a gene was cloned that encodes a member of a P. knowlesi family of erythrocyte binding proteins. The gene is a member of a family that includes 3 homologous genes located on separate chromosomes. Two genes are expressed as major membrane-bound products that give rise to soluble erythrocyte binding proteins: the 135 000 MW Duffy binding protein and a 138 000 MW protein that binds only rhesus erythrocytes. These different erythrocyte binding specificities may result from sequence divergence of the homologous genes. The Duffy receptor family was found to be localized in micronemes of late schizonts and free merozoites. KW - Biochemistry KW - Developmental stages KW - genes KW - merozoites KW - Molecular genetics KW - parasites KW - proteins KW - Apicomplexa KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - Duffy binding protein KW - erythrocyte binding proteins KW - growth phase KW - micronemes KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874336&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Equine infectious anemia virus tat: insights into the structure, function, and evolution of lentivirus trans-activator proteins. AU - Dorn, P. AU - DaSilva, L. AU - Martarano, L. AU - Derse, D. JO - Journal of Virology JF - Journal of Virology Y1 - 1990/// VL - 64 IS - 4 SP - 1616 EP - 1624 SN - 0022-538X AD - Dorn, P.: D. Derse, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013, USA. N1 - Accession Number: 19902210002. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - Equine infectious anaemia virus (EIAV) contains a tat gene which is closely related to the trans-activator genes of the human and simian immunodeficiency viruses. Nucleotide sequence analysis of EIAV cDNA clones showed that the tat mRNA is composed of three exons; the first two encode Tat and the third may encode a Rev protein. Interestingly, EIAV Tat translation is initiated at a non-AUG codon in exon 1 of the mRNA, perhaps allowing an additional level of gene regulation. The deduced amino acid sequence of EIAV tat, combined with functional analyses of tat cDNAs in transfected cells, has provided some unique insights into the domain structure of Tat. EIAV Tat has a C-terminal basic domain and a highly conserved 16-amino-acid core domain, but not the cysteine-rich region, that are present in the primate immunodeficiency virus Tat proteins. Thus, EIAV encodes a relatively simple version of this kind of trans activator. KW - Amino acids KW - Gene expression KW - Genes KW - horse diseases KW - Messenger RNA KW - Molecular biology KW - nucleotide sequences KW - Structure KW - viral diseases KW - viral proteins KW - equine infectious anemia virus KW - horses KW - Lentivirus KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Equus KW - Equidae KW - Perissodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - DNA sequences KW - Equine infectious anaemia virus KW - Function KW - mRNA KW - Rev KW - Tat KW - viral infections KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902210002&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of cDNAs encoding equine infectious anemia virus Tat and putative Rev proteins. AU - Stephens, R. M. AU - Derse, D. AU - Rice, N. R. JO - Journal of Virology JF - Journal of Virology Y1 - 1990/// VL - 64 IS - 8 SP - 3716 EP - 3725 SN - 0022-538X AD - Stephens, R. M.: N.R. Rice, Laboratory of Molecular Virology and Carcinogenesis, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21701, USA. N1 - Accession Number: 19902209268. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Veterinary Science; Veterinary Science; Agricultural Biotechnology N2 - Six cDNA clones were isolated and characterized from an equine infectious anaemia virus-infected cell line that displays a Rev-defective phenotype. With the exception of one splice site in one of the clones, all six cDNAs showed the same splicing pattern and consisted of four exons. Exon 1 contained the 5' end of the genome; exon 2 contained the tat gene from mid-genome; exon 3 consisted of a small section of env, near the 5' end of the env gene; and exon 4 contained the putative rev open reading frame from the 3' end of the genome. The structures of the cDNAs predict a bicistronic message in which Tat is encoded by exons 1 and 2 and the presumptive Rev protein is encoded by exons 3 and 4. tat translation appears to be initiated at a non-AUG codon within the first 15 codons of exon 1. Equine infectious anaemia virus-specific tat activity was expressed in transient transfections with cDNA expression plasmids. The predicted wild-type Rev protein contains 30 env-derived amino acids and 135 rev open reading frame residues. All of the cDNAs had a frameshift in exon 4, leading to a truncated protein and thus providing a plausible explanation for the Rev-defective phenotype of the original cells. Peptide antisera were used to detect the faulty protein, thus confirming the cDNA sequence, and to detect the normal protein in productively infected cells. KW - Biotechnology KW - DNA KW - gene expression KW - Genes KW - horse diseases KW - Molecular biology KW - nucleotide sequences KW - Proteins KW - RNA KW - viral diseases KW - equine infectious anemia virus KW - horses KW - LENTIVIRUS KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Equus KW - Equidae KW - Perissodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - DNA sequences KW - Equine infectious anaemia virus KW - ribonucleic acid KW - viral infections KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902209268&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent studies of human calcium metabolism using stable isotopic tracers. AU - Yergey, A. L. AU - Abrams, S. A. AU - Vieira, N. E. AU - Eastell, R. AU - Hillman, L. S. AU - Covell, D. G. JO - Canadian Journal of Physiology and Pharmacology JF - Canadian Journal of Physiology and Pharmacology Y1 - 1990/// VL - 68 IS - 7 SP - 973 EP - 976 SN - 0008-4212 AD - Yergey, A. L.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911435248. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 11 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition N2 - Calcium metabolism was studied in premature infants, 2 weeks old, after adding 44Ca to a feed of the milk formula and injecting 46Ca intravenously before feeding. Older children and adults were given 44Ca in a drink with a normal food; 42Ca was used as the intravenous tracer. Thermal ionization mass spectrometry was used to measure calcium isotope ratios with a relative accuracy of about 1% for natural abundance ratios and a precision of about 1% relative to the mean. Changes of natural abundance ratios for calcium in blood, urine, and faeces had a limit of detection of about 2 Δ% excess (observed ratio-natural abundance ratio) natural abundance ratio × 100. The mathematical rationale for clinical studies of fractional absorption of dietary calcium and the kinetics of calcium's internal distribution are presented. KW - Calcium KW - estimation KW - isotopes KW - metabolism KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435248&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of dihydrofolate reductase of Pneumocystis carinii and Toxoplasma gondii. AU - Kovacs, J. A. AU - Allegra, C. J. AU - Masur, H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1990/// VL - 71 IS - 1 SP - 60 EP - 68 SN - 0014-4894 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, Building 10, Room 10D48, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19900865226. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9002-03-3. Subject Subsets: Protozoology; Public Health N2 - The dihydrofolate reductase (DHFR) of P. carinii and T. gondii was characterized to facilitate the identification of more selective DHFR inhibitors as potential antiprotozoal agents. Similar to all reported protozoa, T. gondii has a bifunctional enzyme of 120 000 MW, that possesses both DHFR and thymidylate synthase (TS) activity. Unexpectedly, P. carinii DHFR activity was present on a small molecule of MW 26 000. T. gondii DHFR and TS activity coeluted during affinity chromatography using a methotrexate-Sepharose column, whereas P. carinii DHFR and TS activity were separated by affinity chromatography using the same column. P. carinii DHFR was easily distinguished from rat DHFR, which is similar in size, by the differences in Kmfor dihydrofolate (P. carinii, 17.6 ± 3.9 µM; rat, 4.0 ± 2.2 µM). Since all protozoa reported have a large MW, bifunctional DHFR, these studies support the classification of P. carinii as a fungus. KW - biochemistry KW - dihydrofolate reductase KW - enzymes KW - Human diseases KW - Opportunistic infections KW - parasites KW - Taxonomy KW - Apicomplexa KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - fungus KW - systematics KW - tetrahydrofolate dehydrogenase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865226&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunological involvement in the efficacy of praziquantel. AU - Brindley, P. J. AU - Sher, A. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1990/// VL - 71 IS - 2 SP - 245 EP - 248 SN - 0014-4894 AD - Brindley, P. J.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900866713. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 55268-74-1. Subject Subsets: Helminthology; Tropical Diseases N2 - Recent findings concerning the involvement of immune responses in the mode of action of praziquantel (primarily in relation to experimental Schistosoma mansoni infections) are reviewed. KW - activity KW - Anthelmintics KW - helminths KW - Human diseases KW - immune response KW - immunology KW - mode of action KW - parasites KW - Praziquantel KW - Digenea KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900866713&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin D status and related parameters in a healthy population: the effects of age, sex, and season. AU - Sherman, S. S. AU - Hollis, B. W. AU - Tobin, J. D. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1990/// VL - 71 IS - 2 SP - 405 EP - 413 SN - 0021-972X AD - Sherman, S. S.: Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19911433299. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition N2 - The effects of age, sex, renal function and seasonal variation on serum values within the vitamin D endocrine system were studied cross-sectionally in a healthy population of 167 men and 114 women, 20 to 94 years old. Serum 25-hydroxy-cholecalciferol (250HCC) and 1,25-dihydroxycholecalciferol (1,25DiOHCC) did not decline with age in either sex. Nonlinear regression analyses showed a significant seasonal variation in 25OHCC and 1,25DiOHCC in both sexes. Serum intact parathyrin (PTH) increased significantly by 35% over the age range in both sexes. In women, serum phosphorous and total and ionized calcium concentrations were constant with age. In men, P concentration decreased 25% across the age range and total ionized Ca decreased 4%. Creatinine clearance was reduced with age, but was not related to 1,25DiOHCC in either sex. Only in men was there a significant but modest inverse relation between creatinine clearance and PTH (r = -0.212). It is concluded that in healthy persons compromised vitamin D status or serum 1,25DiOHCC concentrations are not a normal concomitant of aging; declining glomerular filtration is not the principle cause of the age-related rise in PTH; and there are marked sex differences in P metabolism across the age range. KW - age KW - blood KW - seasonal variation KW - sex differences KW - Vitamin D KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - seasonal changes KW - seasonal fluctuations KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433299&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Frequency of variant antigens in Giardia lamblia. AU - Nash, T. E. AU - Banks, S. M. AU - Alling, D. W. AU - Merritt, J. W., Jr. AU - Conrad, J. T. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1990/// VL - 71 IS - 4 SP - 415 EP - 421 SN - 0014-4894 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Rm. 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19910868607. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The rate of antigenic variation and the size of the variant antigen repertoire were estimated in clones of G. lamblia which reexpresses surface variant antigens that are characteristics of its parent. Calculations were based on determinations of the number of trophozoites expressing defined or nondefined epitopes as well as the total number of trophozoites in newly established clones. The rate of appearance of variant antigens containing defined epitopes was expressed as the number of generations until the first trophozoite expressing a defined epitope appeared. In clones of isolate WB, tested because their major surface variant antigens were largely nondefined, variants expressing epitopes recognized by Mabs 6E7 or 3F6 appeared after approximately 12 generations. Variants expressing epitopes recognized by MAb 5C1 appeared at about 13 generations, significantly greater than for the other epitopes. The rate of antigenic variation was studied in another isolate, GS/M, whose surface epitope repertoire differs from that of isolate WB. A single epitope recognized by MAb G10/4 was tested. Trophozoites reexpressing this epitope first appeared after about 6.5 generations, significantly less than in WB. Therefore, the single epitope studied in isolate GS/M is reexpressed much more frequently than those of WB. In isolate WB, the epitopes recognized by MAb 6E7 and 3F6 tended to appear at the same time. The median number of variant antigens in WB was estimated to lie between 20.5 and 184.<new para>ADDITIONAL ABSTRACT:<new para>The authors have examined the rates of generation of variant surface proteins in Giardia lamblia. They showed that from clonal origins 11 to 13 generations were required to detect the appearance of the antigens by use of a range of monoclonal antibodies to previously defined surface determinants of the parasite. The period to reappearance of an antigen previously detected in one isolate was as short as 6.5 generations. The authors discuss the parallels that exist between the Giardia variant surface proteins and the Trypanosoma variant surface proteins.It is clear that the investigation of this phenomenon in Giardia is in its infancy and it remains to be seen how extensive the range of variant proteins is. The authors raise questions concerning the biological significance of these observations in relation to disease. Do the surface variations allow evasion of host immune responses and hence persistence of the parasite in the host? S.G. Wright KW - antigenic variation KW - antigens KW - Human diseases KW - parasites KW - Giardia duodenalis KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - Giardia lamblia KW - immunogens KW - variant antigen types KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910868607&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food and nutrient intake differences between smokers and non-smokers in the US. AU - Subar, A. F. AU - Harlan, L. C. AU - Mattson, M. E. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1990/// VL - 80 IS - 11 SP - 1323 EP - 1329 SN - 0090-0036 AD - Subar, A. F.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Executive Plaza North 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19911435700. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - Data from the Second National Health and Nutrition Examination Survey were analysed to estimate food and nutrient intake differences between smokers and non-smokers. Smokers in several age-race-sex categories had lower intakes of vitamin C, folate, fibre and vitamin A than non-smokers, and intake decreased as cigarette consumption increased, particularly for vitamin C, fibre and folate. Smokers were less likely to have consumed vegetables, fruits (particularly fruits and vegetables high in vitamins C and A), high fibre grains, low fat milk, and vitamin and mineral supplements than non-smokers. A negative linear trend was found between smoking intensity and intake of several categories of fruits and vegetables. Data suggest that the high cancer risk associated with smoking is compounded by lower intake of nutrients and foods which are thought to be cancer-protective. KW - Cows KW - diets KW - Food intake KW - intake KW - milk KW - skim milk KW - tobacco smoking KW - USA KW - cattle KW - Man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Milk and Dairy Produce (QQ010) KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435700&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fruit and vegetables in the American diet: data from the NHANES II survey. AU - Patterson, B. H. AU - Block, G. AU - Rosenberger, W. F. AU - Pee, D. AU - Kahle, L. L. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1990/// VL - 80 IS - 12 SP - 1443 EP - 1449 SN - 0090-0036 AD - Patterson, B. H.: Clinical and Diagnostic Trials Section, Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Rm 344, Bethesda, MD 20892, USA. N1 - Accession Number: 19911435695. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Potatoes N2 - 24-h dietary recall data from the Second National Health and Nutrition Examination Survey (1976-80) were used to estimate the numbers of servings of fruit and vegetables consumed by black and white adults, to examine the types of servings (e.g. potatoes, garden vegetables, fruit and juice), and to estimate the mean intake of energy, fat, dietary fibre and vitamins A and C by number of servings. An estimated 45% of the population had no servings of fruit or juice and 22% had no servings of a vegetable on the recall day. Only 27% consumed the 3 or more servings of vegetables and 29% had the 2 or more servings of fruit recommended by the US Departments of Agriculture and of Health and Human Services; 9% had both. Consumption was lower among blacks than whites. The choice of vegetables lacked variety. Diets including at least 3 servings of vegetables and 2 servings of fruit contained about 17 g of dietary fibre. Although energy and fat intake increased with increasing servings of fruit and vegetables, the % of energy from fat remained relatively constant. Although these data are 10 years old, more recent surveys have shown similar results. The discrepancy between dietary guidelines and the actual diet suggests a need for extensive public education. KW - Diet studies KW - fruit KW - intake KW - Nutrition KW - vegetables KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435695&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Herbicides and non-Hodgkin's lymphoma: new evidence from a study of Saskatchewan farmers. AU - Blair, A. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1990/// VL - 82 IS - 7 SP - 544 EP - 545 SN - 0027-8874 AD - Blair, A.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Rm. 418, Bethesda, MD 20892, USA. N1 - Accession Number: 19902303558. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Weeds N2 - A commentary is presented on the results of a study of nearly 70 000 farmers aged ≥35 years in Saskatchewan which showed that areas sprayed with herbicide and expenditure on fuel in 1970 were independently associated with the incidence of non-Hodgkin's lymphoma. Farmers who spent more on herbicides, or sprayed more herbicide were more likely to contract the disease. These results are discussed in relation to previous case-control studies which mostly found a similar relationship, and with laboratory experimental evidence which failed to show a relationsuip between the use of phenoxyacetic acid herbicides and non-Hodykin's lymphoma. KW - Herbicides KW - toxicology KW - Canada KW - Saskatchewan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Canada KW - weedicides KW - weedkillers KW - Pesticides and Drugs (General) (HH400) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902303558&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. AU - Howe, G. R. AU - Hirohata, T. AU - Hislop, T. G. AU - Iscovich, J. M. AU - Yuan, J. M. AU - Katsouyanni, K. AU - Lubin, F. AU - Marubini, E. AU - Modan, B. AU - Rohan, T. AU - Toniolo, P. AU - Shunzhang, Y. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1990/// VL - 82 IS - 7 SP - 561 EP - 569 SN - 0027-8874 AD - Howe, G. R.: Epidemiology Unit, National Cancer Institute of Canada, McMurrich Building, 3rd Fl., 12 Queen's Park Crescent West, University of Toronto, Toronto, Ont. M5S 1A8, Canada. N1 - Accession Number: 19911453936. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - A combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer is presented in this review. Analysis shows a consistent, significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women. A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and significant inverse association with breast cancer risk. If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premenopausal women. KW - Carcinoma KW - diets KW - mammary glands KW - Canada KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453936&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase. AU - Allegra, C. J. AU - Boarman, D. AU - Kovacs, J. A. AU - Morrison, P. AU - Beaver, J. AU - Chabner, B. A. AU - Masur, H. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1990/// VL - 85 IS - 2 SP - 371 EP - 379 SN - 0021-9738 AD - Allegra, C. J.: National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, Bethesda, MD 20892, USA. N1 - Accession Number: 19900864664. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology N2 - It was shown that the dihydropteroate synthase in T. gondii is kinetically distinct from the enzyme characterized from other sources and can be highly purified with a high yield using sequential dye-affinity chromatography. Conditions that allow for stabilization of the purified enzyme were identified, and its physical characteristics were elucidated. The MW of the native protein was 125 000 and the protein appeared to contain both dihydropteroate synthase and 6-hydroxymethyl-dihydropterin pyrophosphokinase activities. The sulfonamide class of compounds varied in inhibitory potency by more than 3 orders of magnitude. Sulfathiazole, sulfamethoxazole, and sulfamethazine, with 50% inhibitory concentrations (IC50s) of 1.7, 2.7, and 5.7 µM, respectively, represent the most potent of this class of inhibitors. Several sulfone analogues, including dapsone, were identified as highly potent inhibitors with IC50s <1 µM. The results of these cell-free experiments were corroborated by investigating the metabolic inhibition produced by the various inhibitors in intact organisms. The qualitative and quantitative relationships between the inhibitors were preserved in both the cell-free and intact cell assay systems. It is suggested that the sulfones may be important therapeutic agents for the treatment of toxoplasmosis. KW - Antiprotozoal agents KW - biochemistry KW - enzymes KW - Human diseases KW - in vitro KW - mode of action KW - parasites KW - Apicomplexa KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - dihydropteroate synthase KW - sulfones KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864664&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. AU - Kida, Y. AU - Esposito-del Puente, A. AU - Bogardus, C. AU - Mott, D. M. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1990/// VL - 85 IS - 2 SP - 476 EP - 481 SN - 0021-9738 AD - Kida, Y.: D.M. Mott, Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 N. 16th Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19901451303. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Insulin-stimulated glycogen synthase activity in human skeletal muscle as correlated with insulin-mediated glucose disposal rate (M) and is reduced in insulin-resistant subjects. Reduced insulin-stimulated glycogen synthase activity associated with reduced fasting glycogen synthase phosphatase activity has previously been reported in skeletal muscle of insulin-resistant Pima Indians. The time course for insulin stimulation of glycogen synthase and synthase phosphatase during a 2-h high-dose insulin infusion (600 mU/min m²) was studied in 6 insulin-sensitive white persons (group IS) and in 5 insulin-resistant Pima Indians (group IR). Percutaneous muscle biopsies were obtained from the quadriceps femoris muscle after insulin infusion for 0, 10, 20, 40 and 120 min. In group IS, insulin-stimulated glycogen synthase activity increased with time and was significantly higher than in group IR. In groups IS, synthase phosphatase activity increased significantly by 25% at 10 min and then decreased gradually. No significant change in synthase phosphatase occurred in group IR and activity was lower than in group IS at 0 to 20 min. These results suggest that a low basal synthase phosphatase activity and a defect in its response to insulin explain, at least in part, reduced insulin stimulation of skeletal muscle glycogen synthase associated with insulin resistance. KW - enzyme activity KW - insulin KW - Skeletal muscle KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451303&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Population-based study of the developmental outcome of children exposed to chloride-deficient infant formula. AU - Willoughby, A. AU - Graubard, B. I. AU - Hocker, A. AU - Storr, C. AU - Vietze, P. AU - Thackaberry, J. M. AU - Gerry, M. A. AU - McCarthy, M. AU - Gist, N. F. AU - Magenheim, M. AU - Berendes, H. AU - Rhoads, G. G. JO - Pediatrics JF - Pediatrics Y1 - 1990/// VL - 85 IS - 4 SP - 485 EP - 490 SN - 0031-4005 AD - Willoughby, A.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Executive Plaza North Building, Room 630-P, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429456. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 16887-00-6. Subject Subsets: Human Nutrition; Soyabeans N2 - In 1978 and 1979 a large number of children in the USA were given chloride-deficient soya-based infant formula. A representative sample of such children was identified in a southern county by sending a questionnaire by post to the homes of 3639 first- and second-grade children in the public schools. Of the 2329 who responded, 56 reported use of deficient formula and were invited to have developmental testing by 1 of 4 study psychologists at their school. Of the 310 users of other soya formulas, 112 were selected for testing as matched controls on the basis of sex, feeding history, age, birth weight and socio-economic status. After exclusions and refusals, 42 children who used deficient formula and 66 control children were tested using the McCarthy Scales of Children's Abilities. Examiners were unaware of the child's history of formula use. The mean General Cognitive Index was 102.8 in those using deficient formula and 105.4 in controls. After adjustment for demographic differences the children who used chloride-deficient formula had on average 4.9 points less than the controls. The largest difference was in the Quantitative subscale. The results show a significant although small effect of chloride-deficient formula on the long-term developmental outcome of exposed children; however, further study of the results is needed for full confirmation. KW - children KW - chloride KW - deficiency KW - infant formulae KW - infants KW - mental ability KW - School children KW - soyabean products KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - infant formula KW - infant formulas KW - intelligence KW - school kids KW - schoolchildren KW - soybean products KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429456&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans. AU - King, C. L. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1990/// VL - 85 IS - 6 SP - 1810 EP - 1815 SN - 0021-9738 AD - King, C. L.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874378. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2. Subject Subsets: Helminthology N2 - To define the immunoregulatory mechanisms underlying serum IgE levels found in patients with filariasis, polyclonal IgE production by peripheral blood mononuclear cells (PBMC) from 15 patients with either Loa loa or Onchocerca volvulus infections was studied, with a focus on the role of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) in the generation and regulation of the response. Spontaneous in vitro IgE production was elevated in 10 of the 15 patients (836-6464 pg/ml; normals <500 pg/ml). Addition of filarial parasite antigen to PBMC cultures significantly stimulated polyclonal IgE production in an antigen dose-dependent manner in 10 of 12 patients tested. The essential role of IL-4 in the generation of this response was demonstrated when simultaneous addition of anti-IL-4 completely inhibited antigen-stimulated IgE production in all 10 patients studied. An inhibitory role of endogenously produced IFN-γ was also indicated when the addition of anti-IFN-γ to the cultures significantly augmented filarial antigen-stimulated IgE production in these same patients. Addition of 10-1000 U/ml of recombinant human IFN-γ to PBMC completely inhibited parasite antigen-induced IgE production. This study is considered to demonstrate that filarial antigen-stimulated IgE production in patients with filariasis is mediated by IL-4 and down regulated by IFN-γ and suggest that the amount of IgE produced depends on the relative quantity of IL-4 and IFN-γ generated by parasite-specific T cells. KW - antibodies KW - Cytokines KW - Filariids KW - helminths KW - Human diseases KW - IgE KW - immune response KW - interferon KW - interleukin 4 KW - parasites KW - Loa loa KW - man KW - Nematoda KW - Onchocerca volvulus KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - African eyeworm KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874378&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum. AU - Dolan, S. A. AU - Miller, L. H. AU - Wellems, T. E. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1990/// VL - 86 IS - 2 SP - 618 EP - 624 SN - 0021-9738 AD - Dolan, S. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871461. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9001-67-6. Subject Subsets: Protozoology N2 - P. falciparum demonstrates variability in its dependence upon erythrocyte sialic acid residues for invasion. Some lines of P. falciparum invade neuraminidase-treated or glycophorin-deficient erythrocytes poorly, or not at all, while other lines invade such cells at substantial rates. To explore the molecular basis of non-sialic acid dependent invasion, parasite lines were selected from a clone (Dd2) that initially exhibited low invasion of neuraminidase-treated erythrocytes. After maintaining Dd2 for several cycles in neuraminidase-treated erythrocytes, parasite lines were recovered that invaded both untreated and neuraminidase-treated erythrocytes at equivalently high rates (Dd2/NM). The change in phenotype was maintained after removal of selection pressure. Four subclones of Dd2 were isolated and each readily converted from sialic acid dependence to non-sialic acid dependence during continuous propagation in neuraminidase-treated erythrocytes. The neuraminidase-selected lines and the Dd2 clone demonstrated identical restriction fragment length polymorphism markers indicating that the Dd2 clone was not contaminated during the selection process. Parasite proteins that bound to neuraminidase-treated and untreated erythrocytes were indistinguishable among the parent Dd2 clone and the neuraminidase-selected lines. The ability of the Dd2 parasite to change its invasion requirements for erythrocyte sialic acid suggests a switch mechanism permitting invasion by alternative pathways. KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - Human diseases KW - parasites KW - SIALIDASE KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - blood red cells KW - exo-alpha-sialidase KW - neuraminidase KW - parasite host relationships KW - red blood cells KW - sialic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871461&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exposure to a chloride-deficient formula during infancy: outcome at ages 9 and 10 years. AU - Malloy, M. H. AU - Willoughby, A. AU - Graubard, B. AU - Lynch, J. AU - McCarthy, M. AU - Moss, H. AU - Vietze, P. AU - Rhoads, G. G. AU - Berendes, H. JO - Pediatrics JF - Pediatrics Y1 - 1990/// VL - 86 IS - 4 SP - 601 EP - 610 SN - 0031-4005 AD - Malloy, M. H.: Epidemiology Branch/PRP, National Institute of Child Health and Human Development, Executive Plaza North, Room 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19911435164. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition; Soyabeans N2 - A school-based mail survey of the 1978 to 1979 birth cohort of two metropolitan Washington, DC, counties was conducted to find children exposed to the chloride-deficient formulas Neo-Mull-Soy and Cho-Free during infancy. Children who had ingested other soya formulas with an adequate chloride content were also found and matched to the exposed children by sex, race, birth weight, age, mixed feeding status and maternal education. A total of 117 of the exposed children and 261 soya control children were given a battery of psychologic tests in their homes to determine whether intellectual development was affected as a result of exposure to the chloride-deficient formulas. Results showed that there were no differences in scores between groups on the Wechsler Intelligence Scale for Children-Revised, the Boston Naming Test, the Rey-Osterrieth Test, or the FAS Verbal Fluency Test. There was no correlation between duration of exclusive exposure to the chloride-deficient formulas and the Wechsler Intelligence Scale for Children-Revised Full-Scale IQ Score (Pearson product-moment r = -0.0825, P=0.28). It is advised that these results cannot be extrapolated to exposed children with documented hypochloraemic metabolic alkalosis. It is concluded that in children without documented evidence of hypochloraemic metabolic alkalosis, exposure to the chloride-deficient formulas Neo-Mull-Soy or Cho-Free during infancy did not result in any long-term adverse effects on cognitive development. KW - chlorides KW - development KW - infant formulae KW - Infants KW - soyabean products KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - infant formula KW - infant formulas KW - soybean products KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Skeletal muscle metabolism is a major determinant of resting energy expenditure. AU - Zurlo, F. AU - Larson, K. AU - Bogardus, C. AU - Ravussin, E. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1990/// VL - 86 IS - 5 SP - 1423 EP - 1427 SN - 0021-9738 AD - Zurlo, F.: E. Ravussin, National Institutes of Health, 4212 N. 16th Street, Rm. 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19911431092. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Energy expenditure varies among subjects, independent of body size and composition, and persons with a "low" metabolic rate seem to be at higher risk of gaining weight. To assess the importance of skeletal muscle metabolism as a determinant of metabolic rate, 24-h energy expenditure, basal metabolic rate (BMR) and sleeping metabolic rate (SMR) were estimated by indirect calorimetry in 14 subjects (7 men, 7 women; 30±6 years old (mean±s.d.); 79.1±17.3 kg; 22±7% body fat), and compared to forearm oxygen uptake. Values of energy expenditure were adjusted for individual differences in fat-free mass, fat mass, age and sex. Adjusted BMR and SMR, expressed as deviations from predicted values, were correlated with forearm resting oxygen uptake (ml O2/litre forearm) (r = 0.72, P<0.005 and r = 0.53, P=0.05, respectively). These findings suggest that differences in resting muscle metabolism account for part of the variance in metabolic rate among individual persons and may play a role in the pathogenesis of obesity. KW - metabolism KW - Resting energy exchange KW - skeletal muscle KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431092&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. AU - Sher, A. AU - Coffman, R. L. AU - Hieny, S. AU - Scott, P. AU - Cheever, A. W. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1990/// VL - 87 IS - 1 SP - 61 EP - 65 SN - 0027-8424 AD - Sher, A.: Immunology and Cell Biology and Host-Parasite Relations Sections, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874080. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - To investigate the immunological basis of the eosinophil response in schistosomiasis and directly assess the function of eosinophils in egg-induced pathology, mice infected with S. mansoni were injected with a MAb produced against interleukin 5 (IL-5), a cytokine previously shown to stimulate eosinophil differentiation in vitro. This treatment suppressed the generation of eosinophil myelocyte precursors in the bone marrow and reduced to background levels the numbers of mature eosinophils in the marrow, in circulation, and within acute schistosome egg granulomata. Nevertheless, granulomata in the anti-IL-5-treated/eosinophil-depleted mice at 8 weeks of infection were only marginally smaller than those in animals injected with control MAb, and hepatic fibrosis was comparable in the 2 groups. Additional parameters such as worm burden, egg output, and serum IgE levels were unaltered by the anti-IL-5 treatment. In contrast, infected animals injected with MAb against γ interferon (IFN-γ) displayed circulating eosinophil levels that were elevated with respect to control mice, possibly because of an enhanced release of mature eosinophils from the marrow, and developed egg granulomata that were indistinguishable in size and cellular composition from those in control animals. Immunological assays revealed that lymphocytes from acutely infected mice produce large quantities of IL-5 but minimal IFN-γ when stimulated with either egg antigen or mitogen. Taken together, these results indicate that neither IL-5 nor eosinophils are essential for egg-induced pathology but suggest that lymphocytes that belong to the IL-5-producing TH2 subset predominate during acute infection and may induce granuloma formation by the production of other cytokines. KW - Cytokines KW - eosinophilia KW - eosinophils KW - helminths KW - immune response KW - immunopathology KW - interleukin 5 KW - Laboratory animals KW - parasites KW - schistosomiasis KW - treatment KW - Digenea KW - mice KW - Rodents KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - eosinophil leukocytes KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - monoclonal antibody against interleukin 5 KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874080&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. AU - Peterson, D. S. AU - Milhous, W. K. AU - Wellems, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1990/// VL - 87 IS - 8 SP - 3018 EP - 3022 SN - 0027-8424 AD - Peterson, D. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874737. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 516-21-2, 9002-03-3, 500-92-5. Subject Subsets: Protozoology N2 - Analysis of the P. falciparum dihydrofolate reductase (DHFR) from different parasites showed the structural basis for differential susceptibility to the antifolate drugs proguanil and pyrimethamine. Parasites harbouring a pair of point mutations from Ala-16 to Val016 and from Ser-108 to Thr-108 are resistant to cycloguanil (the active metabolite of proguanil) but not to pyrimethamine. A single Asn-108 mutation, on the other hand, confers resistance to pyrimethamine with only a moderate decrease in susceptibility to cycloguanil. Significant cross-resistance to both drugs occurs in parasites having mutations that include Ser-108->Asn-108 and Ile-164->Leu-164. These results reflect the distinct structures of pyrimethamine and cycloguanil and suggest fine differences in binding within the active site cavity of DHFR. Alternative inhibitors, used alone or in combination, may be effective against some strains of cycloguanil- or pyrimethamine-resistant malaria. KW - Antimalarials KW - Antiprotozoal agents KW - cycloguanil KW - dihydrofolate reductase KW - drug resistance KW - molecular genetics KW - parasites KW - proguanil KW - resistance mechanisms KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - chlorguanide KW - chloroguanide KW - cycloguanil embonate KW - tetrahydrofolate dehydrogenase KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874737&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. AU - Pash, J. AU - Popescu, N. AU - Matocha, M. AU - Rapoport, S. AU - Bustin, M. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1990/// VL - 87 IS - 10 SP - 3836 EP - 3840 SN - 0027-8424 AD - Pash, J.: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900180535. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - The gene for human high-mobility-group (HMG) chromosomal protein HMG-14 is located on human chromosome 21q22.3, a region associated with the pathogenesis of Down's syndrome. The expression of this gene was examined in mouse embryos which were trisomic in chromosome 16, and considered to be an animal model for Down's syndrome. RNA blot-hybridization analysis and analysis of HMG-14 protein levels indicated that mouse trisomy 16 embryos contained approx. 1.5 times more HMG-14 mRNA and protein than their normal littermates, suggesting a gene dosage effect. It is suggested that the HMG-14 gene may represent an additional marker for Down's syndrome. KW - animal models KW - Biotechnology KW - Chromosomes KW - Down's syndrome KW - gene expression KW - gene mapping KW - Heteroploidy KW - proteins KW - trisomy KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mongolism KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900180535&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. AU - Aoyama, T. AU - Yamano, S. AU - Guzelian, P. S. AU - Gelboin, H. V. AU - Gonzalez, F. J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1990/// VL - 87 IS - 12 SP - 4790 EP - 4793 SN - 0027-8424 AD - Aoyama, T.: Laboratory of Molecular Carcinogenesis, National Cancer Insitute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19901206664. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9035-51-2. Subject Subsets: Medical & Veterinary Mycology N2 - Twelve forms of human hepatic cytochrome P450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P450s were analysed for their abilities to activate aflatoxin B1 to metabolites having mutagenic or DNA-binding properties. Five forms, P450s IA2, IIA3, IIB7, IIIA3 and IIIA4, activated aflatoxin B1 to mutagenic metabolites as assessed by the production of His revertants of Salmonella typhimurium in the Ames test. The same P450s catalyzed conversion of aflatoxin B1 to DNA-bound derivatives as judged by an in situ assay in which the radiolabelled carcinogen was incubated with cells expressing the individual P450 forms. Seven other human P450s, IIC8, IIC9, IID6, IIE1, IIF1, IIIA5 and IVB1, did not significantly activate aflatoxin B1 as measured by both the Ames test and the DNA-binding assay. Moreover, polyclonal anti-rat liver P450 antibodies that cross-react with individual human P450s IA2, IIA3, IIIA3 and IIIA4 each inhibited aflatoxin B1 activation catalyzed by human liver S-9 extracts. Inhibition ranged from as low as 10% with antibody against IIA3 to as high as 65% with antibody against IIIA3 and IIIA4. It is concluded that metabolic activation of aflatoxin B1 in human liver involves the contribution of multiple forms of P450. KW - Aflatoxins KW - cytochrome P-450 KW - Mycotoxins KW - activation KW - fungal toxins KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206664&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Environmental lead toxicity: nutrition as a component of intervention. AU - Mahaffey, K. R. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1990/// VL - 89 SP - 75 EP - 78 SN - 0091-6765 AD - Mahaffey, K. R.: National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19931457428. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition N2 - The influence of nutritional status on susceptibility to the toxicity of lead is discussed. Emphasis is given to dietary factors of substantial clinical importance. Subtle changes in susceptibility are difficult to evaluate in conditions of overwhelming Pb exposure. It is clear that subtle effects of Pb-exposure on neurobehavioural and cognitive development are a major concern. The role of nutrition is considered to be an adjunct to reduction of environmental Pb exposure, which is the primary means of reducing adverse health effects of Pb. Nutrition should be evaluated as a component of strategies to address this issue. KW - Lead KW - Nutrition KW - Toxicity KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931457428&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The apparent validity of diet questionnaires is influenced by number of diet-record days used for comparison. AU - Potosky, A. L. AU - Block, G. AU - Hartman, A. M. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1990/// VL - 90 IS - 6 SP - 810 EP - 813 SN - 0002-8223 AD - Potosky, A. L.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911436524. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - The effect of the number of diet records used as reference data on the apparent validity of a diet history questionnaire was examined using data from 97 subjects in the Women's Health Trial feasibility study. Pearson correlation coefficients were computed between the estimates of usual individual intake from the questionnaire and estimates from the mean of three 4-day records obtained over a 1-year period, the mean of the 2 most recent records, and the record obtained a year after the start of the study. Results show that the apparent validity of a questionnaire increases when it is compared with a greater number of 4-day food records. More diet-record days should therefore be included when validating other dietary assessment instruments. KW - Diet study techniques KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911436524&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antigenic analysis of Cysticercus cellulosae by crossed immunoelectrophoresis and its role in immune diagnosis of neurocysticercosis. AU - Katti, M. K. AU - Jagannath, C. AU - Gokul, B. N. AU - Chandramuki, A. AU - Sehgal, S. JO - Indian Journal of Medical Research JF - Indian Journal of Medical Research Y1 - 1990/// VL - 91 SP - 39 EP - 43 AD - Katti, M. K.: A. Chandramuki, Department of Medical Microbiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. N1 - Accession Number: 19900864417. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Helminthology N2 - The antigenic composition of Cysticercus cellulosae cysts excised from infected pig and autopsied human brain was analysed by crossed immunoelectrophoresis with an intermediate gel technique using rabbit hyperimmune serum. Normal pork muscle and human brain antigen were used to differentiate parasite-derived components from those of the host. Attempts were made to look for immunodominant antigens by analysing preparations of different parts of cyst (scolex and fluid) using rabbit hyperimmune serum. Twenty three antigenic components were identified in sonicated extract of porcine cyst, of which 15 were parasite-derived. Scolex extract showed 10, cyst fluid 9 and human cyst sonicate 11 parasite-derived antigens. Serum and cerebrospinal fluid of 4 patients with neurocysticercosis reacted with 12 parasite-derived antigens of porcine cyst sonicate (PCS). It is noted that human cyst sonicate lacked 4 of the parasite-derived antigens present in the PCS. KW - antigens KW - characterization KW - counterimmunoelectrophoresis KW - helminths KW - Human diseases KW - immunodiagnosis KW - metacestodes KW - parasites KW - Cestoda KW - Taenia solium KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - antigenicity KW - immunogens KW - parasitic worms KW - pork tapeworm KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864417&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduced mannose incorporation into GDP-mannose and dolichol-linked intermediates of N-glycosylation in hamster liver during vitamin A deficiency. AU - Rimoldi, D. AU - Creek, K. E. AU - Luca, L. M. de JO - Molecular and Cellular Biochemistry JF - Molecular and Cellular Biochemistry Y1 - 1990/// VL - 93 IS - 2 SP - 129 EP - 140 SN - 0300-8177 AD - Rimoldi, D.: Differentiation Control Section, Laboratory of Cellular Carcinogeneis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911436546. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 3458-28-4. Subject Subsets: Human Nutrition N2 - The in vivo incorporation of [2-³H]mannose into GDP-mannose, dolichyl phosphate mannose (Dol-P-Man), lipid-linked oligosaccharides, and glycopeptides of hamster liver was investigated during the progression of vitamin A deficiency. Hamsters maintained on a vitamin A-free diet showed reduced incorporation of mannose into GDP-mannose about 10 days before onset of clinical signs of vitamin A deficiency. The decrease in [2-³H]mannose incorporated into GDP-mannose was accompanied by reduced incorporation of label into Dol-P-Man, lipid linked oligosaccharides and glycopeptides, which became more severe with the progression of vitamin A deficiency. By the time they reached a plateau stage of growth, hamster fed vitamin A-free diet showed a 50% reduction in the amount of [2-³H]mannose converted to GDP-mannose, and the radioactivity associated with Dol-P-Man and glycopeptides was reduced by about 60% compared with retinoic acid-supplemented controls. It is concluded that the reduced incorporation of mannose into lipidic intermediates and glycoproteins observed during vitamin A deficiency is due to impaired GDP-mannose synthesis. KW - liver KW - Mannose KW - metabolism KW - vitamin A deficiency KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypovitaminosis A KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911436546&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive infection with Sarcinosporon inkin in a patient with chronic granulomatous disease. AU - Kenney, R. T. AU - Kwon-Chung, K. J. AU - Witebsky, F. G. AU - Melnick, D. A. AU - Malech, H. L. AU - Gallin, J. I. JO - American Journal of Clinical Pathology JF - American Journal of Clinical Pathology Y1 - 1990/// VL - 94 IS - 3 SP - 344 EP - 350 SN - 0002-9173 AD - Kenney, R. T.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19901207705. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in which S. inkin caused progressive pneumonia in an 18-yr-old man with chronic granulomatous disease. Histological sections of right upper lobe lung tissue showed clusters of globose to oblong hyaline-walled, septate, sporangia throughout the necrotic areas within the pyogranulomas. Pure cultures of S. inkin were recovered from the surgical specimen of the lung. Current status of the taxonomy of S. inkin is reviewed and clarified. Treatment of the patient with amphotericin B (total dose 2 g) and white blood cell transfusions led to clinical and radiographical response. KW - hosts KW - infections KW - lungs KW - predisposition KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Ascomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chronic granulomatous disease KW - fungus KW - Hyphomycetes KW - mitosporic fungi KW - Sarcinosporon KW - Sarcinosporon inkin KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207705&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Do we have a nutritional treatment for age-related cataract or macular degeneration? AU - Sperduto, R. D. AU - Ferris, F. L., III AU - Kurinij, N. JO - Archives of Ophthalmology JF - Archives of Ophthalmology Y1 - 1990/// VL - 108 IS - 10 SP - 1403 EP - 1405 SN - 0003-9950 AD - Sperduto, R. D.: Biometry and Epidemiology Program, National Eye Institute, National Institutes of Health, Bldg 31, Room 6A24, Bethesda, MD 20892, USA. N1 - Accession Number: 19911438644. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition N2 - Animal research and preliminary epidemiological studies have suggested a protective role for vitamins and certain trace minerals with antioxidant capabilities in development of cataract and macular degeneration. This editorial reviews the data and suggests that currently, there is no convincing evidence that nutritional supplementation can affect development or progression of age-related cataracts or age-related macular degeneration. Perception that toxicity from vitamin/mineral supplementation is low and recommended use of supplements for patients with these conditions is queried. Most such supplements are used to treat conditions and complaints for which their efficacy has not been demonstrated. Furthermore, a clear definition of toxicity has not been established for many nutrients, and use of megadoses of these supplements is increasing. There is growing concern that excessive intake of fat-soluble vitamins, some trace minerals and even some water-soluble vitamins, may be associated with toxicity, including undesirable interactions with other drugs and other vitamins. The National Eye Institute's multiyear study of the clinical course and prognosis of age-related macular degeneration and age-related cataract will include a randomized trial component to evaluate effect of vitamin/mineral supplements on development. KW - diet treatment KW - eye diseases KW - Old age KW - reviews KW - diet prescription KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911438644&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of Toxoplasma gondii in paraffin-embedded sections by the polymerase chain reaction. AU - Brézin, A. P. AU - Egwuagu, C. E. AU - Burnier, M., Jr. AU - Silveira, C. AU - Mahdi, R. M. AU - Gazzinelli, R. T. AU - Belfort, R., Jr. AU - Nussenblatt, R. B. JO - American Journal of Ophthalmology JF - American Journal of Ophthalmology Y1 - 1990/// VL - 110 IS - 6 SP - 599 EP - 604 SN - 0002-9394 AD - Brézin, A. P.: C. E. Egwuagu, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg.10, Rm.10N202, Bethesda, MD 20892, USA. N1 - Accession Number: 19910881494. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology N2 - The polymerase chain reaction was used to amplify DNA fragments specific to T. gondii (RH strain). The sensitivity of the technique allowed for the detection of as few as 10 cultured T. gondii tachyzoites. The same amplification technique was applied to deparaffinized ocular sections from 2 cases of ocular toxoplasmosis, a 50-year-old man and a 30-year-old man, both from Brazil. Although toxoplasmic cysts could only be seen in one eye by optical microscopy, polymerase chain reaction allowed the identification of the parasite in both cases. This study indicates the feasibility of a sensitive DNA-based assay to complement pathological studies of an ocular parasitic disease. KW - case reports KW - diagnosis KW - eyes KW - human diseases KW - parasites KW - polymerase chain reaction KW - Toxoplasmosis KW - Brazil KW - South America KW - Apicomplexa KW - man KW - protozoa KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910881494&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Localization of myosin IC and myosin II in Acanthamoeba castellanii by indirect immunofluorescence and immunogold electron microscopy. AU - Baines, I. C. AU - Korn, E. D. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1990/// VL - 111 IS - 5, I SP - 1895 EP - 1904 SN - 0021-9525 AD - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900869162. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - Polyclonal antisera were raised against purified Acanthamoeba myosin II and to a synthetic 26 amino acid peptide that corresponds in sequence to the phosphorylation site of Acanthamoeba myosin IC. These antisera are specific for their respective antigens as determined by immunoblotting after SDS-PAGE of total cell lysates. By using the antisera, localization studies were performed by indirect immunofluorescence and by immunogold electron microscopy. Myosin II occurred in the cell cytoplasm and appeared to be concentrated in the cortex. Immunogold cytochemistry revealed at high resolution that myosin II is organized into rodlike filaments ~200 nm long. The antibody raised against the myosin IC synthetic peptide recognized both the plasma membrane and the membrane of the contractile vacuole. The plasma membrane of the contractile vacuole. The plasma membrane staining was labile to treatment with saponin suggesting an intimate association of the myosin IC with membrane phospholipids. Immunogold cytochemistry with the antimyosin IC synthetic peptide showed that the myosin IC is closely associated with the membrane bilayer. KW - Biochemistry KW - myosins KW - parasites KW - proteins KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900869162&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Rheumatoid arthritis, methotrexate therapy and Pneumocystis pneumonia. AU - Leff, R. L. AU - Case, J. P. AU - McKenzie, R. T2 - Annals of Internal Medicine JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1990/// VL - 112 IS - 9 SP - 716 EP - 716 SN - 0003-4819 AD - Leff, R. L.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19900865842. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 59-05-2. Subject Subsets: Protozoology N2 - A case of P. carinii pneumonia in a 66-year-old man with rheumatoid arthritis who was treated with low-dose methotrexate without corticosteroids, is reported from Bethesda, USA. Methotrexate therapy had been started 6 months earlier, up to 22.5 mg/week, with marked improvement in the rheumatoid arthritis. A preliminary diagnosis of methotrexate-induced pneumonitis was made when the patient presented with progressive cough, fever and shortness of breath, but bronchoscopy washes revealed clusters of P. carinii cysts. Therapy with high-dose trimethoprim and sulfamethoxazole, followed by pentamidine for a total of 2 weeks resulted in rapid clinical improvement. KW - case reports KW - Human diseases KW - Immunocompromised hosts KW - immunosuppression KW - Methotrexate KW - Opportunistic infections KW - parasites KW - Rheumatoid arthritis KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - amethopterin KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865842&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Are corticosteroids beneficial as adjunctive therapy for Pneumocystis pneumonia in AIDS? AU - Kovacs, J. A. AU - Masur, H. T2 - Annals of Internal Medicine JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1990/// VL - 113 IS - 1 SP - 1 EP - 3 SN - 0003-4819 AD - Kovacs, J. A.: The National Institutes of Health, Bethesda MD 20892, USA. N1 - Accession Number: 19900865719. Publication Type: Editorial. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology N2 - The treatment of P. carinii pneumonia in patients with AIDS, is discussed, with particular reference to recent studies on the use of corticosteroids as adjuvants to specific anti-Pneumocystis therapy. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - corticoids KW - Human diseases KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - treatment KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - corticosteroids KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865719&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Respiratory cryptosporidiosis in a patient with malignant lymphoma: report of a case and review of the literature. AU - Travis, W. D. AU - Schmidt, K. AU - MacLowry, J. D. AU - Masur, H. AU - Condron, K. S. AU - Fojo, A. T. JO - Archives of Pathology and Laboratory Medicine JF - Archives of Pathology and Laboratory Medicine Y1 - 1990/// VL - 114 IS - 5 SP - 519 EP - 522 SN - 0003-9985 AD - Travis, W. D.: Laboratory of Pathology, Bldg 10, Room 2 N212, National Cancer Institute, National Institutes of Health, Bethesda MD 20892, USA. N1 - Accession Number: 19900865713. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - The first case of respiratory cryptosporidiosis recognized at the National Institutes of Health, USA, is reported. An antemortem diagnosis was made based on recognition of acid-fast cryptosporidia in an induced sputum specimen obtained from a 64-year-old woman with malignant lymphoma and an associated profound immunodeficiency. Autopsy confirmed the presence of Cryptosporidium along the apical aspect of the respiratory epithelium lining the trachea, bronchi, and bronchioles. Cryptosporidia were also identified in the duodenum and gallbladder. Immunohistochemical staining of the paraffin-embedded autopsy lung sections using a monoclonal antibody verified the diagnosis of cryptosporidiosis. Review of this case and the literature suggests that respiratory cryptosporidiosis is characterized by a chronic tracheitis, bronchitis, and bronchiolitis but generally does not cause severe pulmonary dysfunction. KW - case reports KW - Human diseases KW - Immunocompromised hosts KW - lungs KW - neoplasms KW - Opportunistic infections KW - parasites KW - North America KW - USA KW - Apicomplexa KW - Cryptosporidium KW - man KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Cryptosporidiidae KW - Eucoccidiorida KW - Apicomplexa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865713&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of the progression of vitamin A deficiency on glucose, galactose and mannose incorporation into sugar phosphates and sugar nucleotides in hamster liver. AU - Shankar, S. AU - Creek, K. E. AU - Luca, L. M. de JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1990/// VL - 120 IS - 4 SP - 361 EP - 374 SN - 0022-3166 AD - Shankar, S.: L.M. de Luca, Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19901450675. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - The incorporation of [2-³H]mannose into dolichyl phosphate mannose and glycoproteins is remarkably reduced in livers of vitamin A-deficient hamsters. To determine whether vitamin A deficiency selectively alters the level of mannose incorporation into sugar phosphates and sugar nucleotides, incorporation of [2-³H]mannose, [5-³H]mannose, [5-³H]glucose and [4,5-³H]galactose into sugar phosphates and sugar nucleotides was studied in vivo. Male hamsters fed on a vitamin A-depleted or a retinoic acid-supplemented (3 μg/g) diet were used at 4, 6 and 8 weeks old; the hamsters were killed at various times after an intraperitoneal injection of the radiolabelled sugar. There was a two- to threefold increase in the amount of [2-³H]mannose in liver of hamsters fed on a vitamin A-depleted diet for 4 weeks, resulting in enhanced incorporation into mannosyl-phosphate and guanosine diphosphate (GDP) mannose. As deficiency progressed, there was a smaller increase in [2-³H]mannose and a significant decrease in [³H]mannose-phosphate and GDP-[³H]mannose, suggesting a decreased mannose kinase activity. [5-³H]Glucose-labelled livers showed a difference in the total uptake of the label or its incorporation into uridine diphosphate glucose and galactose-phosphate during the 8-week study. However, the synthesis of glucosyl-phosphate was reduced by 50 to 90% at 6 and 8 weeks of deficiency, suggesting an impaired glucokinase activity. In hamsters injected with [4,5-³H]galactose only [³H]glucose was found within 5 min in the free-sugar fraction. In contrast, as much as 70% of the label in the sugar phosphate and sugar nucleotide fraction remained as [³H]galactose even at 60 min. These effects on sugar, sugar phosphate and sugar nucleotide formation in part may explain the effects of vitamin A deficiency on glycoconjugate biosynthesis. KW - Vitamin A deficiency KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypovitaminosis A KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450675&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unequal distribution of a stable isotopic calcium tracer between casein and whey fractions of infant formulas, human milk and cow's milk. AU - Abrams, S. A. AU - Vieira, N. E. AU - Yergey, A. L. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1990/// VL - 120 IS - 12 SP - 1672 EP - 1676 SN - 0022-3166 AD - Abrams, S. A.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910445859. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7440-70-2, 9000-71-9. Subject Subsets: Dairy Science; Human Nutrition N2 - Measurement of calcium absorption with tracers assumes a complete equilibration of tracer with milk calcium. In this study, the equilibration of tracer between the micellar casein and soluble fractions (primarily whey) of 2 types of infant formulae (standard cow milk-based and formula for premature infants), human milk and cow milk was measured in vitro, using milk samples enriched with 42Ca and analysed by thermal ionization MS. Incomplete equilibration of tracer occurred with the micellar casein fraction of all milks. The least equilibration with micellar casein was found with premature infant formula, for which the ratio of slopes of the equilibration lines (whey:casein) was 8.5:1. These differences may be due to Ca-casein binding in cow milk-based formulae. The effects of the lack of tracer equilibration in vivo could not be determined. However, unequal bioavailability of casein- vs. whey-bound Ca may exist. KW - Calcium KW - casein KW - Cows KW - distribution KW - human milk KW - infant formulae KW - isotopes KW - milk KW - tracers KW - whey KW - cattle KW - Man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - breast milk KW - infant formula KW - infant formulas KW - Milk and Dairy Produce (QQ010) KW - Human Nutrition (General) (VV100) KW - Physiology of Human Nutrition (VV120) KW - Food Composition and Quality (QQ500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910445859&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dose-response tests in field surveys. AU - Underwood, B. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1990/// VL - 120 IS - 11 suppl. SP - 1455 EP - 1458 SN - 0022-3166 AD - Underwood, B. A.: National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429615. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition N2 - Dose response tests for some nutrients can provide information on the tissue status of a nutrient that may not be reflected by single measures of the concentration in body fluids. Where clear cut-off points for relative nutritional states are not well defined, dose response tests can provide a base for interpretation of values that fall in the poorly defined marginal zones. In large field surveys, dose response tests are constrained by a waiting period, obtaining 2 or more biological samples, and use of sophisticated instrumentation. They should be used on a subsample of the population studied. KW - Nutrition surveys KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - American Institute of Nutrition KW - nutritional surveys KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429615&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Methods for assessment of vitamin A status. AU - Underwood, B. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1990/// VL - 120 IS - 11 suppl. SP - 1459 EP - 1463 SN - 0022-3166 AD - Underwood, B. A.: Office of International Program Activities, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911429617. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 24 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Commonly used indicators of vitamin A status include dietary intakes of the vitamin, serum levels, and dark adaptation; all have limitations in their precision, especially when applied to individuals and to young children. New and developing non-clinical indicators include the relative dose response test or a modification of it, conjunctival impression cytology, and isotope dilution to estimate total body reserves. Currently, the most reliable assessment of vitamin A status occurs when a combination of methods is used. KW - estimation KW - Retinol KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - American Institute of Nutrition KW - axerophthol KW - status KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429617&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Familial goiter in bongo antelope (Tragelaphus eurycerus). AU - Doi, S. AU - Shifrin, S. AU - Santisteban, P. AU - Montali, R. J. AU - Schiller, C. AU - Bush, M. AU - Grollman, E. F. JO - Endocrinology (Philadelphia) JF - Endocrinology (Philadelphia) Y1 - 1990/// VL - 127 IS - 2 SP - 857 EP - 864 SN - 0013-7227 AD - Doi, S.: E. Grollman, National Institutes of Health, Building 10, Room 9B12, Bethesda, MD 20892, USA. N1 - Accession Number: 19911428981. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - Congenital defects in thyroglobulin (Tg) synthesis in animals have proven to be useful models for the study of Tg synthesis and regulation. Defects in Tg synthesis have been well described in Afrikander cattle, Australian Merino sheep, and goats in the Netherlands. A study of goitre in a non-domesticated species, bongo antelope (Tragelaphus eurycerus), an African bovid, is described. Three bongos housed at the National Zoological Park, Washington, DC, USA, were studied; two had visible goitres and a third had microscopic evidence of goitre. Tg extracted from thyroid glands or thyroid colloid had a high molecular weight (mol. wt.) component that was greater than 220 Kdaltons and differed in apparent mol. wt. from 19S Tg from domestic cattle. Thyroid extracts also had thyroid albumin; albumin was more than half the total protein in colloid extract. The bongos with goitre were euthyroid according to their circulating values of thyroid hormones. KW - Goitre KW - antelopes KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - goiter KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911428981&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Altered glucagon- and catecholamine hormone-sensitive adenylyl cyclase responsiveness in rat liver membranes induced by manipulation of dietary fatty acid intake. AU - Dax, E. M. AU - Partilla, J. S. AU - Piñeyro, M. A. AU - Gregerman, R. I. JO - Endocrinology (Philadelphia) JF - Endocrinology (Philadelphia) Y1 - 1990/// VL - 127 IS - 5 SP - 2236 EP - 2240 SN - 0013-7227 AD - Dax, E. M.: Endocrinology Section, Gerontology Research Center, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD 21224, USA. N1 - Accession Number: 19921453053. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9012-42-4, 9007-92-5. Subject Subsets: Human Nutrition N2 - Glucagon- and β-adrenergic-stimulated receptor-adenylyl cyclase systems were examined in liver membranes of male Wistar rats given diets of maize oil as the only source of fatty acids (unsaturated fat diet), hydrogenated coconut oil (saturated fat, essential fatty acid-deficient), or coconut oil plus a minimum required proportion of maize oil to prevent deficiency. Basal and maximal non-receptor mediated adenylyl cyclase activity was the same in membranes of each of the dietary groups. Because β-adrenergic and glucagon receptors in the same membrane use the same coupling components, β-adrenergic stimulated adenylyl cyclase was studied concomitantly with glucagon-stimulated adenylylcyclase to examine whether the receptors per se were responsible for altered hormone response or whether only the Gs guanine nucleotide-sensitive coupling protein interactions or the adenylyl cyclase catalytic unit were influenced by dietary manipulations. The results demonstrate that alterations in the glucagon-stimulated adenylyl cyclase response differ from those in the β-adrenergic adenylyl cyclase response. Furthermore, they suggest that although direct activations of the catalytic unit or its interaction with the guanine nucleotide-sensitive protein do not appear to be affected, hormone receptor-mediated adenylyl cyclase activity may be altered by these dietary manipulations. KW - Adenylate cyclase KW - beta-Adrenergic agonists KW - Coconut oil KW - fatty acids KW - Glucagon KW - intake KW - liver KW - Maize oil KW - Saturated fatty acids KW - sources KW - Unsaturated fatty acids KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - corn oil KW - Animal Models of Human Nutrition (VV140) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921453053&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A developmentally regulated, cyclic-AMP inducible gene expressed by metacyclic trypomastigotes of Trypanosoma cruzi. AU - Heath, S. AU - Vernick, K. AU - Hieny, S. AU - Sher, A. JO - UCLA Symposia on Molecular and Cellular Biology JF - UCLA Symposia on Molecular and Cellular Biology Y1 - 1990/// VL - 130 SP - 27 EP - 33 CY - New York; USA PB - Wiley-Liss Inc SN - 0471567647 AD - Heath, S.: Immunology and Cell Biology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874796. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology KW - development KW - Developmental stages KW - drugs KW - molecular biology KW - molecular genetics KW - parasites KW - vaccines KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - biochemical genetics KW - growth phase KW - medicines KW - pharmaceuticals KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874796&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breast feeding protects infants in Indonesia against illness and weight loss due to illness. AU - Launer, L. J. AU - Habicht, J. P. AU - Kardjati, S. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1990/// VL - 131 IS - 2 SP - 322 EP - 331 SN - 0002-9262 AD - Launer, L. J.: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, EPN Rm 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19931466268. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition N2 - The hypothesis that breast feeding modifies the effect of morbidity on growth was tested by examining, at different levels of breast feeding: number of days ill; and relation between morbidity and weight change. A total of 200 observations made at 3-weekly intervals between 1983 and 1984 on 33 normal-birth-weight breast-fed infants from a rural village on the island of Madura, Indonesia were used. Levels of breast feeding were defined as quartiles (Q1-Q4) of proportion of household visit time spent breast feeding. Regression analysis and analysis of variance were used and within child effects examined. Number of days ill from respiratory tract illness decreased significantly (P=0.01) as quartile of breast feeding increased. Weight change was not affected by respiratory tract illness in Q2-Q4 but was significantly and negatively affected by such illness in the lowest quartile, Q1(β= -22.5±4.8g/day ill). Slopes of Q2-Q4 were not significantly different but were significantly different (P=0.0094) from the Q1 slope. Measurement, reverse causality, or confounding bias did not change the interpretation of findings. It is concluded that that breast feeding protects infants against nutritional consequences of illness by decreasing the number of days with respiratory tract illness and protecting against weight loss due to this form of illness. However the protective effect of breast feeding was attained only when levels of breast feeding were adequate, as at the lowest level of breast feeding, illness had a negative impact on weight performance. KW - Breast feeding KW - Diet studies KW - Growth KW - Health KW - Infants KW - Morbidity KW - Respiratory diseases KW - Weight losses KW - Indonesia KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - lung diseases KW - Diet Studies (VV110) KW - Human Nutrition (General) (VV100) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466268&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer mortality and lipid and lipoprotein levels. The lipid research clinics program mortality follow-up study. AU - Cowan, L. D. AU - O'Connell, D. L. AU - Criqui, M. H. AU - Barrett-Connor, E. AU - Bush, T. L. AU - Wallace, R. B. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1990/// VL - 131 IS - 3 SP - 468 EP - 482 SN - 0002-9262 AD - Cowan, L. D.: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Building, Room 401, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19931454624. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - The associations of serum lipid and lipoprotein levels with the risk of cancer mortality were assessed in 2753 men and 2476 women 40 to 79 years old at baseline (1972 to 1976) who participated in the Lipid Research Clinics Programme Mortality Follow-up Study until 1984. 79 cancer deaths occurred in men and 65 occurred in women during an average follow-up time of 8.4 years. Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly inversely associated with overall cancer mortality in men, but no relation was observed in women. Neither high-density lipoprotein (HDL) cholesterol nor triacylglycerols were significantly related to total cancer mortality in either sex, although in women, HDL cholesterol was positively associated with risk of death from gynaecological cancers. Compared with men with higher cholesterol levels, the relative risk of death from colon cancer, adjusted for age, body mass, cigarette smoking and alcohol consumption, was 5.20 (95% confidence interval (CI) 1.61 to 16.8) in men with total cholesterol levels ≤187 mg/100 ml and 4.79 (95% CI 1.37 to 16.8) in those with LDL cholesterol levels ≤119 mg/100 ml. Death from smoking-related cancers was inversely related to baseline total cholesterol but not to LDL cholesterol. The absence of an association with HDL cholesterol which has been shown to be lower in persons with clinically manifest malignancy, and evidence from survival curves suggest that the inverse relation in men is not due to preexisting disease. KW - Blood KW - Blood lipids KW - Carcinoma KW - Lipoproteins KW - Mortality KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - death rate KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931454624&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of vitamin and mineral supplements: demographics and amounts of nutrients consumed. The 1987 Health Interview Survey. AU - Subar, A. F. AU - Block, G. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1990/// VL - 132 IS - 6 SP - 1091 EP - 1101 SN - 0002-9262 AD - Subar, A. F.: National Institutes of Health, National Cancer Institute, Division of Cancer Prevention and Control, 9000 Rockville Pike, EPN 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19921445075. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - Data from the 1987 National Health Interview Survey showed that 51.1% of the adults aged 18-99 years in the United States had consumed a vitamin/mineral supplement in the previous year, but that only 23.1% did so daily. Whites, women, and older individuals were more likely than blacks, men and younger individuals to consume supplements regularly. Multivitamins were the most commonly consumed supplement, followed by vitamin C, calcium, vitamin E and vitamin A. Results suggest that supplementation practices have changed little since the 1970s. Results regarding the amounts of nutrients obtained from supplements showed that a food frequency type of methodology collects reasonably accurate data reflecting intake of supplements over the previous year. Few, if any, individuals were consuming nutrients in amounts considered toxic. Although vitamin and mineral supplementation is a common health habit, it appears not to pose a significant health risk for most of the population. KW - Diet studies KW - ethnic groups KW - intake KW - mineral supplements KW - Minerals KW - sex differences KW - vitamin supplements KW - Vitamins KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445075&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria. AU - Vinetz, J. M. AU - Kumar, S. AU - Good, M. F. AU - Fowlkes, B. J. AU - Berzofsky, J. A. AU - Miller, L. H. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1990/// VL - 144 IS - 3 SP - 1069 EP - 1074 SN - 0022-1767 AD - Vinetz, J. M.: L.H. Miller, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873232. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology N2 - To further examine the mechanisms of CD8+ T cell involvement in immunity to blood stage P. yoelii infection, in vivo CD8 depletion and adoptive transfer experiments were performed. Depletion of CD8+ T cells during primary blood stage infection in BALB/c mice did not diminish the ability of the mice to resolve their infections. Spleen cells from immune BALB/c and C57BL/10 mice were transferred to BALB/c-nu/nu and C57BL/10-nu/nu mice, respectively. The recipient mice were CD4 depleted in vivo to kill any transferred CD4+ T cells. The mice failed to control the infection. Populations of CD4-, CD8+ T cells were transferred from immune CBA/CaJ donors to in vivo CD4-depleted CBA/CaJ recipients. The mice were unable to control the infection. Although immune unfractionated spleen cells transferred rapid protection in all 3 mouse strains and immune CD4+ T cells transferred immunity in the 2 mouse strains studied, CD8+ T cells by themselves were neither protective nor did they enhance immunity. KW - immunity KW - Laboratory animals KW - parasites KW - Spleen cells KW - T lymphocytes KW - Apicomplexa KW - mice KW - Plasmodium yoelii KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The identification of an Onchocerca-specific recombinant antigen containing a T cell epitope. AU - Colina, K. F. AU - Perler, F. B. AU - Matsumura, I. AU - Meda, M. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1990/// VL - 145 IS - 5 SP - 1551 EP - 1556 SN - 0022-1767 AD - Colina, K. F.: T.B. Nutman, Building 4, Room 126, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873721. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Helminthology N2 - Recombinant Onchocerca volvulus antigens (Ag) were derived from expression libraries and examined for their ability to stimulate peripheral blood mononuclear cells (PBMC) from patients infected with O. volvulus. Ten clones producing recombinant Ag were selected and plaque purified; lysogens were produced and found to express β-galactosidase fusion proteins ranging from 115 to 138 000 MW. When ammonium sulfate-precipitated lysates of these recombinant phage clones were examined for their ability to stimulate PBMC from a patient with onchocerciasis, all 10 recombinants produced stimulation above that to nonrecombinant phage. When individual fusion proteins, affinity purified on anti-β-galactosidase linked to agarose, were used to stimulate PBMC from patients with onchocerciasis, only one of the recombinant Ag induced PBMC proliferation (stimulation index >4) above that to Ag from nonrecombinant phage. Characterization of the DNA coding for this antigen showed it to be 1.2 kb in length with a small (90 bp) open reading frame; furthermore, it appeared to be Onchocerca specific (on genomic dot blots) and single copy. Using overlapping peptides encompassing the entire open reading frame, one T cell epitope was localized. KW - antigens KW - Biotechnology KW - Developmental stages KW - Filariids KW - helminths KW - immune response KW - Molecular genetics KW - nucleotide sequences KW - parasites KW - peripheral blood mononuclear cells KW - man KW - Nematoda KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - growth phase KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - recombinant antigen KW - Secernentea KW - Spirurida KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873721&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. AU - Sher, A. AU - Coffman, R. L. AU - Hieny, S. AU - Cheever, A. W. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1990/// VL - 145 IS - 11 SP - 3911 EP - 3916 SN - 0022-1767 AD - Sher, A.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873388. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 37341-29-0. Subject Subsets: Helminthology N2 - To investigate the role of anaphylactic immune responses in protective immunity against schistosomiasis, mice vaccinated with irradiated cercariae of S. mansoni (NMRI strain) were treated with neutralizing MAbs against either IL-5 or IL-4 before and during challenge infection. Anti-IL-5-treated vaccinated mice showed a complete ablation of circulating as well as tissue eosinophils, present in inflammatory reactions to migrating schistosomula in the skin and lungs, but nevertheless eliminated challenge infections as effectively as vaccinated animals treated with a control MAb. Similarly, treatment of vaccinated mice with an anti-IL-4 MAb markedly reduced serum IgE although failing to diminish immunity. The effect of anti-IL-5 mediated eosinophil depletion was also assessed in a 2nd model in which resistance is induced by concomitant chronic infection. Again, normal, unaltered protection was observed in the absence of circulating and tissue eosinophils. In contrast to the above findings, treatment with anti-IFN-γ was found to cause a partial depletion of immunity in vaccinated mice while, paradoxically, increasing the numbers of inflammatory reactions against invading schistosomula in the lungs. These observations argue against a requirement for either eosinophils or IgE in the anti-schistosome immunity induced by vaccination with irradiated cercariae, or for eosinophils in the resistance resulting from previous infection in mice, and support previous data suggesting a role for an IFN-γ dependent cell-mediated effector mechanism in vaccine-induced resistance. KW - eosinophils KW - Experimental infections KW - helminths KW - Human diseases KW - IgE KW - immune response KW - Immunity KW - Laboratory animals KW - parasites KW - Digenea KW - mice KW - Rodents KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - eosinophil leukocytes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873388&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - B cell responses to paramyosin. Isotypic analysis and epitope mapping of filarial paramyosin in patients with onchocerciasis. AU - Steel, C. AU - Limberger, R. J. AU - McReynolds, L. A. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1990/// VL - 145 IS - 11 SP - 3917 EP - 3923 SN - 0022-1767 AD - Steel, C.: Building 4, Room 126, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873389. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Helminthology N2 - To examine the fine specificity of the human immune response to filarial paramyosin, the antigenicity of an expressed rcDNA (2.55 kb) of Dirofilaria immitis paramyosin was detailed by ELISA. Using sera from patients infected with Onchocerca volvulus, both the entire paramyosin molecule and 6 subcloned fragments were analysed for their IgG, IgG subclasses, and IgE responses. Patients from both Guatemala (64% positive) and Ghana (100% positive) reacted to paramyosin with specific IgG levels above normal controls. Although there was no anti-paramyosin subclass restriction common to all patients, the IgG3 response in the Ghanaians was signficantly greater than that of Guatemalans. IgE anti-paramyosin responses showed positive correlations with IgG2, IgG4 and IgG1 responses. Epitope mapping using the IgG response to the 6 subclones demonstrated preferential recognition of the amino terminal end of the molecule (nucleotides 1 to 360). IgG2 reactivity was clearly localized to the most amino-terminal 120 amino acids, and the IgG4 antibodies recognized amino acids immediately adjacent to this fragment. These studies examining the fine specificity of anti-filarial immune reactions should provide a method for understanding how parasites either evade or induce host immune responses. KW - antigens KW - Filariids KW - helminths KW - Human diseases KW - immune response KW - parasites KW - Dirofilaria immitis KW - man KW - Nematoda KW - Onchocerca volvulus KW - Dirofilaria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - paramyosin KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873389&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cell-mediated immune response to schistosomiasis. AU - James, S. L. AU - Sher, A. T2 - Current Topics in Microbiology and Immunology Y1 - 1990/// VL - 155 SN - 0070-217X AD - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19900863794. Publication Type: Journal Article; Book chapter; Journal article. Language: English. Number of References: 38 ref. Subject Subsets: Helminthology N2 - T-cell mediated immunity in the resistance to and the pathogenesis of schistosomiasis are considered, and the hypothesis that a functional dichotomy exists in the role of TH subsets in the resistance to and pathology of helminth infections is discussed. KW - Cell mediated immunity KW - helminths KW - Human diseases KW - immune response KW - immunopathology KW - parasites KW - resistance KW - T lymphocytes KW - Digenea KW - Schistosoma KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - cellular immunity KW - discussed KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863794&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360°C: practical and theoretical implications. AU - Brown, P. AU - Liberski, P. P. AU - Wolff, A. AU - Gajdusek, D. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 161 IS - 3 SP - 467 EP - 472 SN - 0022-1899 AD - Brown, P.: Bldg. 36, Room 5B21, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19902213690. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 50-00-0. Subject Subsets: Veterinary Science; Veterinary Science; Public Health N2 - Scrapie-infected hamster brains and their extracted amyloid fibrils were subjected to formaldehyde and steam autoclaving, alone or in combination. Treatment with formaldehyde before autoclaving stabilized infectivity, whereas treatment after autoclaving rendered the tissue or extracts inactive or further reduced infectivity. In additional experiments on specimens (not treated with formaldehyde) that were subjected to dry heat, a small amount of infectivity still survived a 1-hour exposure to temperatures as high as 360°C. These results are consistent with the operation of a comparatively primitive molecular mechanism for the initiation of scrapie agent replication (perhaps an inorganic crystal nucleation step) and the subsequent participation of an organic macromolecule (scrapie amyloid protein) that is susceptible to intramolecular cross-stabilization by formaldehyde. KW - Ashing KW - Autoclaving KW - cat diseases KW - disinfection KW - Formaldehyde KW - Heat KW - Prion proteins KW - Scrapie agent KW - viral diseases KW - cats KW - Hamsters KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Cricetinae KW - Muridae KW - rodents KW - prions KW - brain tissue KW - formaldehyde and autoclaving KW - viral infections KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902213690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis. AU - Walsh, T. J. AU - Aoki, S. AU - Mechinaud, F. AU - Bacher, J. AU - Lee, J. AU - Rubin, M. AU - Pizzo, P. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 161 IS - 4 SP - 755 EP - 760 SN - 0022-1899 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19911207962. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - To investigate the potential use of fluconazole for prevention and treatment of disseminated Candida albicans infections in granulocytopenic patients, its in vivo antifungal activity was studied in 3 models of disseminated candidosis in persistently granulocytopenic rabbits: acute, subacute and chronic disseminated candidosis. Fluconazole was compared with the combination of amphotericin B and flucytosine for preventive, early and late treatment of disseminated candidosis, depending on the model. Fluconazole was most effective when used for preventive or early treatment of acute and subacute disseminated candidosis. When compared with the combination of amphotericin B plus flucytosine, fluconazole was similarly effective in early treatment of acute and subacute disseminated candidosis. When treatment was delayed 6 d after established infection, fluconazole was less active in clearing tissues in comparison with its activity in preventive and early treatment. The combination of amphotericin B plus flucytosine, however, was significantly more active than fluconazole in treatment of chronic disseminated candidosis in all tissues. It is concluded that fluconazole is most effective against disseminated candidosis in persistently granulocytopenic rabbits when used for prevention or early treatment. KW - amphotericin B KW - Antifungal agents KW - fluconazole KW - flucytosine KW - generalized infections KW - infections KW - predisposition KW - prophylaxis KW - therapy KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 5-fluorocytosine KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911207962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Granulocyte-macrophage colony-stimulating factor augments human monocyte fungicidal activity for Candida albicans. AU - Smith, P. D. AU - Lamerson, C. L. AU - Banks, S. M. AU - Saini, S. S. AU - Wahl, L. M. AU - Calderone, R. A. AU - Wahl, S. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 161 IS - 5 SP - 199 EP - 1005 SN - 0022-1899 AD - Smith, P. D.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19901207158. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The ability of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) to augment the fungicidal activity of human monocytes for C. albicans was evaluated. Purified human monocytes cultured with [³H]leucine-labelled C. albicans caused a dose-dependent release of the [³H]leucine. The amount of [³H]leucine released correlated with a decrease in the number of viable yeast colonies. Monocyte cytotoxicity for C. albicans was reduced by superoxide dismutase and catalase and by inhibitors of myeloperoxidase and scavengers of hydroxyl radical and singlet oxygen, consistent with monocyte candidacidal activity being partly dependent upon products of oxidative metabolism. Monocytes incubated with rhGM-CSF produced more superoxide anion (O2-) spontaneously and after stimulation than control monocytes (P<0.05). Enhanced O2- production was dose-dependent and specific for rhGM-CSF and could be inhibited by antibody to rhGM-CSF. In association with rhGM-CSF-induced production of O2-, the cytokine enhanced cytotoxic activity for C. albicans. It is concluded that rhGM-CSF stimulates human monocyte fungicidal activity for C. albicans. KW - immunology KW - monocytes KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207158&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Candida albicans in patients with the acquired immunodeficiency syndrome: absence of a novel or hypervirulent strain. AU - Whelan, W. L. AU - Kirsch, D. R. AU - Kwon-Chung, K. J. AU - Wahl, S. M. AU - Smith, P. D. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 162 IS - 2 SP - 513 EP - 518 SN - 0022-1899 AD - Whelan, W. L.: P. D. Smith, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911208311. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology N2 - To determine whether C. albicans in patients with AIDS represents a unique strain, C. albicans isolated from 24 patients with AIDS was compared with Candida isolated from 23 healthy adults. Resistance to 5-fluorocytosine [flucytosine], synthesis of amino acids and nucleotides, sugar use and enzyme activity patterns were similar among isolates from the 2 groups. Molecular analysis revealed similar banding patterns of EcoRI restriction fragments of DNA between 2.5-3 and 6-7 kb. In addition, the frequency of a dimorphic 3.7- versus 4.2-kb band, identified by agarose gel electrophoresis and by probing Southern transfers of EcoRI digests with a cloned fragment of C. albicans DNA encoding 25S ribosomal RNA, was not significantly different between the AIDS-derived and control C. albicans. C. albicans isolated at different time points in the course of disease and from different sites in individual patients showed identical DNA fingerprints. It is concluded that the similarity in isolates of C. albicans that cause disease in AIDS patients and those present in healthy subjects indicate that the candidosis associated with AIDS is not due to the presence of an unique or particularly virulent strain but is likely the consequence of a defect in host defence mechanisms. KW - acquired immune deficiency syndrome KW - biotypes KW - candidosis KW - clinical aspects KW - DNA KW - epidemiology KW - genetics KW - hosts KW - infections KW - isolation KW - mouth KW - oesophagus KW - Opportunistic infections KW - Pathology KW - phenotypes KW - predisposition KW - restriction fragment length polymorphism KW - USA KW - Candida albicans KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - candidiasis KW - clinical picture KW - deoxyribonucleic acid KW - esophagus KW - fungus KW - Hyphomycetes KW - RFLP KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Normal and deficient neutrophils can cooperate to damage Aspergillus fumigatus hyphae. AU - Rex, J. H. AU - Bennett, J. E. AU - Gallin, J. I. AU - Malech, H. L. AU - Melnick, D. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 162 IS - 2 SP - 523 EP - 528 SN - 0022-1899 AD - Rex, J. H.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911208313. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Using a metabolic test of hyphal viability, the interaction between neutrophils and Aspergillus hyphae was investigated over a broad range of hyphae-to-neutrophil ratios. Normal neutrophils were found to damage hyphae whereas neutrophils from patients with both chronic granulomatous disease (CGD) and myeloperoxidase (MPO) deficiency did not. Further, both azide and catalase + superoxide dismutase inhibited the ability of normal neutrophils to damage hyphae, indicating that this damage is mediated by products of the respiratory burst and by the MPO-halide system. Also, mixtures of small numbers of normal neutrophils with larger numbers of CGD neutrophils (range, 1:5 to 1:15) damaged hyphae more efficiently than either population of cells alone. Further, mixtures of CGD and MPO-deficient neutrophils, neither of which alone could efficiently damage hyphae, were able to damage the hyphae almost as well as a comparable number of normal neutrophils. It is concluded that intact neutrophils can cooperate to synergistically damage Aspergillus hyphae, possibly by extracellular mixing of hydrogen peroxide and MPO. KW - immunology KW - neutrophils KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Flucytosine interference in creatinine assay. AU - Bennett, J. E. AU - Kroll, M. H. AU - Washburn, R. G. T2 - Journal of Infectious Diseases JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1990/// VL - 162 IS - 2 SP - 571 EP - 572 SN - 0022-1899 AD - Bennett, J. E.: Laboratory of Clinical Investigation and Clinical Chemistry Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931214400. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Registry Number: 60-72-5, 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - In reply to a previous report [Kennedy, C. A. (et al.) Journal of Infectious Diseases (1989) 160, 1090-1091], it is noted that flucytosine interference with the old EKTACHEM serum creatinine assay is well known to clinical chemistry laboratories and that most now use the new "one-slide" method which has no interference from flucytosine. KW - antagonism KW - Antifungal agents KW - creatinine KW - Flucytosine KW - 5-fluorocytosine KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214400&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thin-walled cavities, cysts, and pneumothorax in Pneumocystis carinii pneumonia: further observations with histopathologic correlation. AU - Feuerstein, I. M. AU - Archer, A. AU - Pluda, J. M. AU - Francis, P. S. AU - Falloon, J. AU - Masur, H. AU - Pass, H. I. AU - Travis, W. D. JO - Radiology JF - Radiology Y1 - 1990/// VL - 174 IS - 3 SP - 697 EP - 702 SN - 0033-8419 AD - Feuerstein, I. M.: Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, Bldg 10, Rm 1C660, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910870294. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology N2 - Thin-walled pulmonary cystic lesions were found in 5 immunocompromised patients from the USA, 4 with AIDS. Four patients had P. carinii pneumonia, and one had pulmonary lesions and disseminated P. carinii infection. Two patients demonstrated P. carinii within necrotizing, thin-walled, smaller intraparenchymal cavities lined by organisms, exudate, and chronic inflammation. Pneumothorax in the 4 patients with AIDS could not be cured by closed thoracostomy drainage; all required pleurodesis. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - case reports KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Lungs KW - Opportunistic infections KW - parasites KW - pneumothorax KW - Respiratory diseases KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - lung diseases KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910870294&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells. AU - Yancey, P. H. AU - Burg, M. B. AU - Bagnasco, S. M. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1990/// VL - 258 IS - 1 Pt 1 SP - C156 EP - C163 SN - 0002-9513 AD - Yancey, P. H.: M. B. Burg, Bldg. 10, Rm 6N307, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921448371. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 50-99-7, 7647-14-5, 50-70-4. Subject Subsets: Human Nutrition N2 - To analyse the effects of sorbitol accumulation on the survival and growth of epithelial cells from rabbit renal inner medulla, cloning efficiency (an index of cell viability) was estimated at normal and high glucose and NaCl concentrations and when sorbitol accumulation was prevented by Tolrestat and Sorbinil, which inhibit aldose reductase. With PAP-HT25 cells grown to near confluence, high NaCl increases aldose reductase activity, causing enough rise in cell sorbitol concentration to balance most of the increased osmolality of the high extracellular NaCl. Inhibition of aldose reductase prevents both the increased enzyme activity and sorbitol accumulation in a dose-related manner. Paralleling this, colony-forming efficiency is not affected by the inhibitors at a normal NaCl concentration but is greatly reduced when extracellular NaCl is high. On the other hand, high glucose levels, as occur in diabetes, increase sorbitol content well above the concentration required for osmotic balance and inhibit colony-forming efficiency. Under those conditions, aldose reductase inhibitors lower cell sorbitol and reverse (at 300 to 350 mosmol/kg H2O) or reduce (at 500 to 550 mosmol/kg H2O) the decrease in colony-forming efficiency caused by high glucose. Thus, sorbitol accumulation is necessary for osmoregulation when induced by high osmolality but is harmful when induced by high glucose. KW - cell cultures KW - cells KW - enzyme inhibitors KW - glucose KW - Kidneys KW - sodium chloride KW - sorbitol KW - cloning KW - dextrose KW - NaCl KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. AU - Zurlo, F. AU - Lillioja, S. AU - Esposito del Puente, A. AU - Nyomba, B. L. AU - Raz, I. AU - Saad, M. F. AU - Swinburn, B. A. AU - Knowler, W. C. AU - Bogardus, C. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1990/// VL - 259 IS - 5,I SP - E650 EP - E657 SN - 0002-9513 AD - Zurlo, F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 19921450289. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - The 24-h respiratory quotient (RQ) was measured in 152 non-diabetic Pima Indians fed a weight-maintenance diet (87 males and 65 females; 27±6 years (mean±standard deviation); 93.9±22.9 kg body weight; 32±9% fat). The RQ varied from 0.799 to 0.903. Prior change in body weight, 24-h energy balance, sex, and percent body fat explained 18% of the variance in RQ (P<0.001). In a subgroup of 66 siblings from 28 families, family membership explained 28% of the remaining variance in RQ (P<0.05). In 111 subjects for whom follow-up data (25±11 months) were available, RQ was correlated with subsequent changes in body weight and fat mass (r = 0.27, P<0.01 and r = 0.19, P<0.05, respectively). Subjects with higher RQ (90th percentile) independent of 24-h energy expenditure were at 2.5 times higher risk of gaining ≥5 kg body weight than those with lower RQ (10th percentile). It is concluded that, in Pima Indians fed a standard diet, family membership is the principal determinant of the ratio of fat to carbohydrate oxidation, and a low ratio of fat to carbohydrate oxidation is associated with subsequent weight gain independent of low energy expenditure and may contribute to the familial aggregation of obesity. KW - body fat KW - body weight KW - energy exchange KW - Ethnic groups KW - families KW - obesity KW - sex differences KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921450289&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Acanthamoeba myosin I heavy chain kinase is activated by phosphatidylserine-enhanced phosphorylation. AU - Brzeska, H. AU - Lynch, T. J. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1990/// VL - 265 IS - 7 SP - 3591 EP - 3594 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920800050. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology N2 - It was shown that kinase isolated from Acanthamoeba castellanii by a procedure designed to minimize its phosphorylation during purification can incorporate up to 7.5 mol of phosphate/mol of enzyme when incubated with ATP, possibly by autophosphorylation. The rate of phosphorylation was enhanced about 20-fold by phosphatidylserine but was unaffected by calcium ions. Phosphorylation increased the rate at which the kinase phosphorylates the regulatory site of myosin I by about 50-fold. It is suggested that (auto? )phosphorylation may regulate the activity of myosin I heavy chain kinase in vivo. It is considered that the stimulation of kinase phosphorylation by phosphatidylserine (other phospholipids have not been tested) is of particular interest because myosin I has been shown to be tightly associated with membranes, especially the plasma membrane. KW - Biochemistry KW - enzymes KW - Human diseases KW - Kinases KW - MYOSINS KW - parasites KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800050&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning metabolic pathway genes by complementation in Escherichia coli. Isolation and expression of Plasmodium falciparum glucose phosphate isomerase. AU - Kaslow, D. C. AU - Hill, S. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1990/// VL - 265 IS - 21 SP - 12337 EP - 12341 SN - 0021-9258 AD - Kaslow, D. C.: Bldg. 4, Rm. BI-37, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900867357. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9001-41-6. Subject Subsets: Protozoology; Agricultural Biotechnology; Tropical Diseases N2 - Genetic complementation of an E. coli double mutant was used to isolate and express the gene coding for P. falciparum glucose phosphate isomerase. The gene contains a 1773-base pair open reading frame, has no introns, and maps to P. falciparum chromosome 14. 34% of the deduced amino acid sequence is identical to human glucose phosphate isomerase, with highest similarity in regions of the proposed active sites. The putative initiation site of translation was determined by deletional and oligonucleotide mediated, site-specific mutagenasis. This data suggests that key metabolic enzymes of Plasmodium can be cloned and expressed in E. coli without prior knowledge of the primary amino acid or nucleic acid structure. KW - Biotechnology KW - gene mapping KW - genes KW - glucose-6-phosphate isomerase KW - Human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Apicomplexa KW - Escherichia coli KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - bacterium KW - biochemical genetics KW - DNA sequences KW - E. coli KW - glucose phosphate isomerase KW - nucleotide sequence KW - phosphoglucose isomerase KW - phosphohexose isomerase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900867357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium. AU - Waters, A. P. AU - Thomas, A. W. AU - Deans, J. A. AU - Mitchell, G. H. AU - Hudson, D. E. AU - Miller, L. H. AU - McCutchan, T. F. AU - Cohen, S. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1990/// VL - 265 IS - 29 SP - 17974 EP - 17979 SN - 0021-9258 AD - Waters, A. P.: Malaria Section, Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872362. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The complete sequence of the 66 000 MW merozoite surface antigen (PK66) which allowed the demonstration that highly conserved analogues exist throughout P. knowlesi including a recently reported gene from P. falciparum is reported. These analogues are highly promising vaccination candidates. The distribution of PK66 changed after schizont rupture in a coordinate manner associated with merozoite invasion. The protein was concentrated at the apical end prior to rupture, following which it could distribute itself entirely across the surface of the free merozoite. During invasion, immunofluorescence studies suggested that, PK66 is excluded from the erythrocyte at, and behind, the invasion interface.<new para>ADDITIONAL ABSTRACT:<new para>The authors report the sequence of a full-length cDNA encoding the Plasmodium knowlesi 66 000 Mr surface antigen (PK66) which is thought to have a role in erythrocyte invasion. Highly conserved analogues exist throughout the genus Plasmodium.Carolyn A. Brown KW - antigens KW - Biotechnology KW - Candidate vaccines KW - Developmental stages KW - Human diseases KW - Malaria KW - merozoites KW - nucleotide sequences KW - parasites KW - Proteins KW - receptors KW - surface antigens KW - Vaccines KW - Apicomplexa KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - antigenicity KW - DNA sequences KW - growth phase KW - immunogens KW - PK66 KW - surface KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new Acanthamoeba myosin heavy chain. Cloning of the gene and immunological identification of the polypeptide. AU - Horowitz, J. A. AU - Hammer, J. A., III JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1990/// VL - 265 IS - 33 SP - 20646 EP - 20652 SN - 0021-9258 AD - Horowitz, J. A.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804166. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology N2 - The gene for an Acanthamoeba myosin heavy chain, whose tail domain amino acid sequence distinguishes it from Acanthamoeba myosins IB, IC and II, spans ~6.8 kb, is split by 17 introns, and encodes a 177 000 MW polypeptide. The amino-terminal ~90 000 MW of this polypeptide was highly similar to the globular head sequences of myosins I and II, its ~87 000 MW tail domain shows essentially no similarity to the tail sequences of either type of myosin. The only exception to this is the carboxyl-terminal ~50-amino acid region of the polypeptide, which is homologous to the carboxyl termini of the myosins I. This ~50-residue segment was shown previously to exist in a diverse family of cytoskeleton-associated proteins that included non-receptor tyrosine kinases, phospholipase Cγ, and fodrin. Sequence analysis indicated that the tail domain of this new myosin is incapable of forming a myosin II-like coiled-coil structure. This implies that the protein is single-headed and nonfilamentous, and is tentatively classified as a high MW form of myosin I (HMWMI). To determine whether HMWMI existed in cells, antiserum was raised against a bacterially expressed fusion peptide made using a cDNA clone encoding most of the unique HMWMI tail domain. This antiserum does not recognize Acanthamoeba myosin IB, IC or II but does recognize a single polypeptide in whole cell extracts with the mobility predicted for the HMWMI heavy chain. The protein is precipitated from crude extracts using F-actin and released from the pellet by ATP, which supported its classification as a member of the myosin family of proteins. KW - Complementary DNA KW - Genes KW - Human diseases KW - Molecular genetics KW - MYOSINS KW - Nucleotide sequences KW - parasites KW - Acanthamoeba KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cDNA KW - Cloning KW - DNA sequences KW - myosin KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804166&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of essential fatty acid deficiency on the adrenergic activation of glycogenolysis in rat hepatocytes. AU - Grojec, M. S. AU - Ishac, E. J. N. AU - Kapocsi, J. AU - Kunos, G. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1990/// VL - 283 IS - 1 SP - 34 EP - 39 SN - 0003-9861 AD - Grojec, M. S.: G. Kunos, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, 12501 Washington Avenue, Rockville, MD 20852, USA. N1 - Accession Number: 19911437055. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - The fatty acid composition of total lipids and the adrenoceptor-mediated activation of glycogenolysis were studied in isolated hepatocytes from male Sprague-Dawley rats fed a standard or an essential fatty acid (EFA)-free diet. In cells from rats on the EFA-free diet there was a marked reduction in linoleic and arachidonic acid (AA) and an increase in eicosatrienoic, oleic, and palmitoleic acid compared to controls. In freshly isolated cells from both groups, phosphorylase a (E.C. 2.4.1.1.) activity was increased by phenylephrine or epinephrine but not by isoprenaline, and the effect of epinephrine was inhibited by phenoxybenzamine but not by propranolol. When control cells were preincubated in a serum-free buffer for 4 h, the effect of phenylephrine on phosphorylase a activity was reduced, isoprenalene became a potent agonist and the effect of epinephrine was partially inhibited either by phenoxybenzamine or by propranolol. The emerging β-adrenergic response in 4-h cells was associated with a marked potentiation of isoprenaline-induced cAMP accumulation. A similar 4-h preincubation of EFA-deficient cells resulted in a reduced response to phenylephrine while isoprenaline was ineffective, for increasing phosphorylase a activity or cAMP production. The response of these 4-h cells to isoprenaline could be restored by in vivo replacement of the EFA-deficient diet with standard chow diet for the last 4 weeks prior to the experiment, but not by the in vitro exposure of the EFA-deficient cells to 10 µM AA throughout the 4-h incubation period. Results suggest that the time-dependent emergence of β-adrenergic glycogenolysis is mediated by AA or its metabolite(s), which probably act by facilitating the G-protein-dependent coupling of β-receptors. KW - fat deficiencies KW - Glycogenolysis KW - liver cells KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - essential fatty acid deficiency KW - hepatocytes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911437055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis. AU - Ottesen, E. A. AU - Vijayasekaran, V. AU - Kumaraswami, V. AU - Pillai, S. V. P. AU - Sadanandam, A. AU - Frederick, S. AU - Prabhakar, R. AU - Tripathy, S. P. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1990/// VL - 322 IS - 16 SP - 1113 EP - 1116 SN - 0028-4793 AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19950804178. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 90-89-1, 1642-54-2, 70288-86-7. Subject Subsets: Helminthology N2 - To compare the efficacy and side effects of ivermectin with those of diethylcarbamazine, the standard antifilarial treatment, a randomized double-blind trial in 40 south Indian men with lymphatic filariasis caused by Wuchereria bancrofti was carried out. Patients were randomly assigned to one of 3 treatments. A single low dose (1 mg) of ivermectin followed by placebo for 12 days; a single high dose (6 mg) of ivermectin followed by 12 days of placebo; or diethylcarbamazine (150 mg) for 13 days. At day 12 there was complete clearance of microfilariae from the blood in all 26 men who took ivermectin and in 11 of the 14 men who took diethylcarbamazine. At 6 months the numbers of detectable microfilariae (as a percentage of pre-treatment values) were 18.3% after low-dose ivermectin and 19.5% after high-dose ivermectin, compared with 6% after diethylcarbamazine. Side effects (fever, headache, lethargy and myalgia) were confined to the first 5 days and were similar in all 3 groups. It is concluded that in lymphatic filariasis ivermectin given as a single dose compares favourably with the standard 12-day course of diethylcarbamazine. KW - anthelmintics KW - diethylcarbamazine KW - drug therapy KW - filariasis KW - helminths KW - human diseases KW - ivermectin KW - microfilariae KW - parasites KW - man KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Wuchereria KW - Onchocercidae KW - chemotherapy KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804178&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. AU - Pekkanen, J. AU - Linn, S. AU - Heiss, G. AU - Suchindran, C. M. AU - Leon, A. AU - Rifkind, B. M. AU - Tyroler, H. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1990/// VL - 322 IS - 24 SP - 1700 EP - 1707 SN - 0028-4793 AD - Pekkanen, J.: B.M. Rifkind, Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Building, Rm. 401, Bethesda, MD 20892, USA. N1 - Accession Number: 19901452188. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - A total of 2541 white men, 40 to 69 years old at base line, were followed for on average 10.1 years as part of the Lipid Research Clinics Program Prevalence Study in 10 North American populations between 1972 and 1976; 17% had some manifestation of cardiovascular disease (CVD) at base line. Among the men who had CVD at base line, those with blood cholesterol above 6.19 mmol/litre had a risk of death from CVD, including CHD, 3.45 times higher (95% confidence interval 1.63 to 7.33) than that for men with blood cholesterol below 5.16 mmol/litre. The corresponding hazard ratios were 5.92 (95% confidence interval 2.59 to 13.51) for low-density lipoprotein (LDL) cholesterol concentration above 4.13 mmol/litre as compared with those below 3.35 mmol/litre and 6.02 (95% confidence interval 2.73 to 13.28) for high-density lipoprotein (HDL) cholesterol concentrations below 0.90 mmol/litre as compared with those above 1.16 mmol/litre. All lipid values were also predictors of death from CHD alone. Total cholesterol and LDL cholesterol concentrations were also significant predictors of death from CVD and CHD in men without pre-existing CVD, although at a lower level of absolute risk of death. Thus, the 10-year risk of death from CVD for a man with pre-existing CVD increased from 3.8 to almost 19.6% with increasing levels of total cholesterol from 5.16 to 6.19 whereas the corresponding risk for a man who was free of CVD at base line increased from 1.7 to 4.9%. The findings suggest that total LDL and HDL cholesterol concentrations predict subsequent mortality in men 40 to 69 years old, especially those with pre-existing CVD. KW - blood KW - Cardiovascular diseases KW - cholesterol KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis pneumonia in the acquired immunodeficiency syndrome. AU - Masur, H.\Meier, P.\McCutchan, J. A.\Feinberg, J.\Bernard, G.\Bozzette, S. A.\Clement, M.\Ellenberg, S. S.\Feigal, D. W.\Gagnon, S.\Mathews, C. W.\Mills, J.\Montaner, J.\Nielsen, J. O.\Sattler, F. R.\Spector, S.\Tilles, J. G. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1990/// VL - 323 IS - 21 SP - 1500 EP - 1504 SN - 0028-4793 AD - H. Masur, Clinical Center 10d48, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910869374. Publication Type: Journal Article. Corporate Author: National Institutes of Health-University of California expert panel for corticosteroids as adjunctive therapy for Pneumocystis pneumonia. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology N2 - Five recently-completed, randomized trials assessing the efficacy of adjunctive therapy with corticosteroids for AIDS-associated Pneumocystis pneumonia were reviewed by a panel of experts under the sponsorship of the National Institutes of Health and the California Universitywide AIDS Research Program. It was found that 3 of the 5 studies suggest that short-term mortality from Pneumocystis pneumonia is reduced by adjunctive therapy with corticosteroids. Two studies found that steroids prevent further declines in arterial oxygen levels after specific therapy is initiated. The report covers the background and the conceptual basis for assessing the 5 trials, summaries of each of the case studies, the panels' conclusions and recommendations, as well as other issues addressed by the panel (adjunctive corticosteroids in pregnant women with HIV infection or immunosuppressed patients without HIV infection, adjunctive corticosteroids in patients in whom specific anti-Pneumocystis therapy is failing, and other studies that are needed). KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - corticoids KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - treatment KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - corticosteroids KW - fungus KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Searching for the yeast connection. AU - Bennett, J. E. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1990/// VL - 323 IS - 25 SP - 1766 EP - 1767 SN - 0028-4793 AD - Bennett, J. E.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19911207933. Publication Type: Editorial. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The chronic candidosis syndrome is discussed and it is concluded that scientifically sound studies are needed to determine whether the syndrome does or does not exist. KW - allergies KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911207933&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. AU - Wellems, T. E. AU - Panton, L. J. AU - Gluzman, I. Y. AU - Rosario, V. E. do AU - Gwadz, R. W. AU - Walker-Jonah, A. AU - Krogstad, D. J. JO - Nature (London) JF - Nature (London) Y1 - 1990/// VL - 345 IS - 6272 SP - 253 EP - 255 SN - 0028-0836 AD - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19900867389. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Protozoology N2 - Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites resistant to chloroquine expel the drug rapidly in an unaltered form, thereby reducing levels of accumulation in the vesicles. The discovery that verapamil partially reverses chloroquine resistance in vitro led to the proposal that efflux may involve an ATP-driven P-glycoprotein pump similar to that in mammalian multidrug-resistant (mdr) tumor cell lines. Indeed, P. falciparum contains at least 2 mdr-like genes, one of which has been suggested to confer the chloroquine resistant (CQR) phenotype. To determine if either of these genes was linked to chloroquine resistance, a genetic cross between CQR and chloroquine susceptible (CQS) clones of P. falciparum was performed. Examination of 16 independent recombinant progeny indicated that the rapid efflux phenotype is controlled by a single gene or a closely linked group of genes. But, there was no linkage between the rapid efflux, CQR phenotype and either of the mdr-like P. falciparum genes or amplification of those genes. The results indicate that the genetic locus governing chloroquine efflux and resistance is independent of the known mdr-like genes. KW - Antimalarials KW - Antiprotozoal agents KW - chloroquine KW - drug resistance KW - genetics KW - Human diseases KW - parasites KW - Apicomplexa KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900867389&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of age on duodenal 1,25-dihydroxyvitamin D-3 receptors in Wistar rats. AU - Takamoto, S. AU - Seino, Y. AU - Sacktor, B. AU - Liang, C. T. JO - Biochimica et Biophysica Acta (G), General Subjects JF - Biochimica et Biophysica Acta (G), General Subjects Y1 - 1990/// VL - 1034 IS - 1 SP - 22 EP - 28 AD - Takamoto, S.: C.T. Liang, Laboratory of Biological Chemistry, National Institute of Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19901451626. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 32222-06-3, 7440-70-2. Subject Subsets: Human Nutrition N2 - Previous studies show that duodenal Ca2+ absorption and serum 1,25-dihydroxyvitamin D (1,25-DHD) values decrease with maturity. Receptor preparations from rats 6 and 24 months old, were incubated with ³H-labelled 1,25-dihydroxycholecalciferol (1,25-DHCC) to quantify the number of unoccupied and total receptor sites and showed that total and unoccupied receptor sites decreased by 22 and 16%, respectively, in old rats. Endogenously occupied sites were reduced by 43% in duodenum of the old rat and, consequently, the percentage of receptor, occupancy also declined. Age did not affect the dissociation constant (KD) of 1,25-DHCC from the receptor; the sedimentation coefficient (3.3 S) of the tritiated 1,25-DHCC receptor complex in sucrose density centrifugation or its affinity for DNA. The data are consistent with the hypothesis that the age-related decline in Ca2+ absorption in the intestine may be due, in part, to the decrease in the circulating value of 1,25-DHD and a reduction of intestinal 1,25-DHCC receptor occupancy status. KW - absorption KW - age KW - blood KW - calcitriol KW - Calcium KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451626&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Sporotrichosis. AU - Bennett, J. E. A2 - Warren, K. S. A2 - Mahmoud, A. A. F. T2 - Tropical and geographical medicine. JO - Tropical and geographical medicine. JF - Tropical and geographical medicine. Y1 - 1990/// IS - Ed. 2 SP - 1007 EP - 1008 CY - New York; USA PB - McGraw-Hill, Inc. SN - 007068328X AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19911210371. Publication Type: Miscellaneous. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The pathogenesis and pathology, clinical manifestations, differential diagnosis and treatment of Sporothrix schenckii infections are discussed. KW - hosts KW - infections KW - man KW - Sporothrix schenckii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antifungal agents. AU - Bennett, J. E. A2 - Mandell, G. L. A2 - Douglas, R. G., Jr. A2 - Bennett, J. E. T2 - Principles and practice of infectious diseases. JO - Principles and practice of infectious diseases. JF - Principles and practice of infectious diseases. Y1 - 1990/// IS - Ed. 3 SP - 361 EP - 370 CY - New York; USA PB - Churchill Livingstone Inc. SN - 0443086869 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931214317. Publication Type: Miscellaneous. Language: English. Number of References: 115 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Major topical antifungal agents including Whitfield's ointment, polyenes and imidazoles, oral antifungals such as griseofulvin, ketoconazole and terbinafine, and treatment of deep mycoses with amphotericin B, flucytosine, ketoconaozle, itraconazole and fluconazole are reviewed. KW - Antifungal agents KW - reviews KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Aspergillus species. AU - Bennett, J. E. A2 - Mandell, G. L. A2 - Douglas, R. G., Jr. A2 - Bennett, J. E. T2 - Principles and practice of infectious diseases. JO - Principles and practice of infectious diseases. JF - Principles and practice of infectious diseases. Y1 - 1990/// IS - Ed. 3 SP - 1958 EP - 1962 CY - New York; USA PB - Churchill Livingstone Inc. SN - 0443086869 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931214319. Publication Type: Miscellaneous. Language: English. Number of References: 79 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The epidemiology, pathogenesis and pathological characteristics, clinical manifestations, involving ear and sinus, eye, lung, central nervous system and other sites, diagnosis and treatment of Aspergillus infections are reviewed. KW - hosts KW - infections KW - reviews KW - Aspergillus KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214319&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Sporothrix schenckii. AU - Bennett, J. E. A2 - Mandell, G. L. A2 - Douglas, R. G., Jr. A2 - Bennett, J. E. T2 - Principles and practice of infectious diseases. JO - Principles and practice of infectious diseases. JF - Principles and practice of infectious diseases. Y1 - 1990/// IS - Ed. 3 SP - 1972 EP - 1975 CY - New York; USA PB - Churchill Livingstone Inc. SN - 0443086869 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931214321. Publication Type: Miscellaneous. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Mycology, epidemiology, clinical manifestations, diagnosis, treatment and prognosis are discussed for Sporothrix schenckii infections. KW - hosts KW - infections KW - man KW - Sporothrix schenckii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214321&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Miscellaneous fungi. AU - Bennett, J. E. A2 - Mandell, G. L. A2 - Douglas, R. G., Jr. A2 - Bennett, J. E. T2 - Principles and practice of infectious diseases. JO - Principles and practice of infectious diseases. JF - Principles and practice of infectious diseases. Y1 - 1990/// IS - Ed. 3 SP - 2031 EP - 2034 CY - New York; USA PB - Churchill Livingstone Inc. SN - 0443086869 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931214330. Publication Type: Miscellaneous. Language: English. Number of References: 71 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Miscellaneous fungal infections, caused by Pseudallescheria boydii, Prototheca spp., Emmonsia crescens, Rhinosporidium seeberi, Loboa loboi, dematiaceous fungi and others, are briefly discussed. KW - infections KW - Ajellomyces crescens KW - Chlorellaceae KW - Chlorellales KW - Loboa loboi KW - Man KW - Onygenales KW - Prototheca KW - Pseudallescheria boydii KW - Rhinosporidium seeberi KW - Emmonsia KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Loboa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Chlorellaceae KW - Chlorellales KW - Chlorophyta KW - algae KW - plants KW - aquatic plants KW - aquatic organisms KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Sordariomycetes KW - Rhinosporidium KW - Protozoa KW - invertebrates KW - Ajellomyces KW - Emmonsia crescens KW - fungus KW - Lacazia KW - Lacazia loboi KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Malaria. AU - Miller, L. H. AU - Warrell, D. A. A2 - Warren, K.S. A2 - Mahmoud, A.A.F. T2 - Tropical and Geographical Medicine. Y1 - 1990/// IS - Ed.2 CY - New York; USA PB - McGraw-Hill, Inc. SN - 007068328X AD - Miller, L. H.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874752. Publication Type: Book chapter. Language: English. Number of References: 65 ref. Subject Subsets: Protozoology N2 - A general account of malaria is given with discussion of the following topics: life cycle in humans; parasite biology, intracellular physiology, and biochemistry; parasite genetics; parasite evolution; patient; innate resistance; immunity to asexual erythrocytic parasites; pathogenesis and pathology; clinical manifestations; treatment; population; epidemiology; malaria control and eradication; malaria research. KW - Human diseases KW - Malaria KW - parasites KW - reviews KW - tropical medicine KW - Apicomplexa KW - man KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874752&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Leishmaniasis. AU - Neva, F. AU - Sacks, D. A2 - Warren, K.S. A2 - Mahmoud, A.A.F. T2 - Tropical and Geographical Medicine. Y1 - 1990/// IS - Ed.2 CY - New York; USA PB - McGraw-Hill, Inc. SN - 007068328X AD - Neva, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874756. Publication Type: Book chapter. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology N2 - Human infections caused by species of Leishmania are outlined under the headings of: parasite: taxonomy; morphology and ultrastructure; life cycle; in vitro cultivation; patient: pathology; immunology; clinical manifestations; diagnosis; therapy; population: vectors and reservoirs; control. KW - Human diseases KW - Leishmaniasis KW - parasites KW - tropical medicine KW - Leishmania KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - General account KW - leishmaniosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874756&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The filariases and tropical eosinophilia. AU - Ottesen, E. A. A2 - Warren, K.S. A2 - Mahmoud, A.A.F. T2 - Tropical and Geographical Medicine. Y1 - 1990/// IS - Ed.2 CY - New York; USA PB - McGraw-Hill, Inc. SN - 007068328X AD - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874770. Publication Type: Book chapter. Language: English. Number of References: 66 ref. Subject Subsets: Helminthology N2 - The filarial diseases caused by Wuchereria bancrofti, Brugia malayi, B. timori, Loa loa, Mansonella perstans, M. streptocerca and M. ozzardi are discussed in turn. The pathogenesis and pathology, clinical manifestations, treatment, transmission and control of each species, are reviewed. KW - Filariasis KW - filariids KW - helminths KW - Human diseases KW - parasites KW - reviews KW - tropical medicine KW - Brugia malayi KW - Brugia timori KW - Loa loa KW - man KW - Mansonella ozzardi KW - Mansonella perstans KW - Mansonella streptocerca KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Mansonella KW - Wuchereria KW - African eyeworm KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874770&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Trichomoniasis. AU - Quinn, T. C. AU - Krieger, J. N. A2 - Warren, K.S. A2 - Mahmoud, A.A.F. T2 - Tropical and Geographical Medicine. Y1 - 1990/// IS - Ed.2 CY - New York; USA PB - McGraw-Hill, Inc. SN - 007068328X AD - Quinn, T. C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874763. Publication Type: Book chapter. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology N2 - A comprehensive discussion of trichomoniasis in man is given under the following headings and subheadings: parasite: biology; antigenic analysis; patient: pathophysiology; histopathology; clinical manifestations (sites of infection; infections in women; infections in men; neonatal trichomonal infection; diagnosis); management; population: epidemiology; transmission; control. KW - Human diseases KW - parasites KW - Trichomoniasis KW - tropical medicine KW - man KW - protozoa KW - Sarcomastigophora KW - Trichomonadidae KW - Trichomonas vaginalis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Protozoa KW - Trichomonadida KW - Sarcomastigophora KW - Trichomonas KW - Trichomonadidae KW - trichomonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874763&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Perspectives on immunopathology in lymphatic filariasis. AU - Ottesen, E. A. T2 - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990. JO - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990. JF - Proceedings of a seminar on future research needs in lymphatic filariasis, 8-10 October 1990. Y1 - 1990/// SP - 25 EP - 28 CY - Pondicherry; India PB - Vector Control Research Centre AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920884397. Publication Type: Conference paper. Language: English. Number of References: 6 ref. Subject Subsets: Helminthology N2 - The current knowledge of immunopathology in man due to infection with Wuchereria bancrofti and Brugia malayi is discussed. The most significant pathology associated with bancroftian and brugian filariasis is localized in 3 organ systems: the lymphatics (acute inflammation, oedema, hydrocoele, elephantiasis and chyluria), the lung (tropical pulmonary eosinophilia syndrome) and the kidneys (haematuria, proteinuria). It has been suggested that the amount of pathology induced by filarial parasites is proportional to the vigour of the host's immune response. KW - filariasis KW - filariids KW - helminths KW - human diseases KW - immunopathology KW - kidneys KW - lungs KW - parasites KW - pathology KW - Brugia malayi KW - man KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Wuchereria KW - immunopathogenesis KW - lymphatics KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920884397&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Ecology of Cryptococcus neoformans and prevalence of its two varieties in AIDS and non-AIDS associated cryptococcosis. AU - Kwon-Chung, K. J. AU - Varma, A. AU - Howard, D. H. A2 - Bossche, H. vanden A2 - Mackenzie, D. W. R. A2 - Cauwenbergh, G. A2 - Cutsem, J. van A2 - Drouhet, E. A2 - Dupont, B. T2 - Mycoses in AIDS patients. JO - Mycoses in AIDS patients. JF - Mycoses in AIDS patients. Y1 - 1990/// SP - 103 EP - 113 CY - New York; USA PB - Plenum Press SN - 030643704X AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. N1 - Accession Number: 19921212155. Publication Type: Conference paper. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The ecology of C. neoformans, epidemiology of C. neoformans var. neoformans and var. gattii, prevalence of C. neoformans var. gattii among AIDS and non-AIDS patients in the same geographical area, and DNA polymorphism among isolates of C. neoformans serotype A from AIDS and non-AIDS patients are discussed. KW - acquired immune deficiency syndrome KW - epidemiology KW - infections KW - predisposition KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus neoformans KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - AIDS KW - Cryptococcus neoformans var. gattii KW - fungus KW - Mycoses in AIDS patients KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212155&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immunization of monkeys with baculovirus recombinant-expressed dengue envelope and NS1 glycoproteins induces partial resistance to challenge with homotypic dengue virus. AU - Lai, C. J. AU - Zhang, Y. M. AU - Men, R. AU - Bray, M. AU - Chanock, R. M. AU - Dubois, D. R. AU - Eckels, K. H. A2 - Brown, F. A2 - Chanock, R.M. A2 - Ginsberg, H.S. A2 - Lerner, R.A. T2 - Vaccines 90: modern approaches to new vaccines including prevention of AIDS. JO - Vaccines 90: modern approaches to new vaccines including prevention of AIDS. JF - Vaccines 90: modern approaches to new vaccines including prevention of AIDS. Y1 - 1990/// SP - 119 EP - 124 CY - Cold Spring Harbor, New York; USA PB - Cold Spring Harbor Laboratory Press SN - 087969341X AD - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940502928. Publication Type: Miscellaneous. Language: English. Number of References: 9 ref. N2 - The envelope (E) glycoprotein and the NS1 nonstructural glycoprotein of dengue type-4 virus had been identified as independent protective antigens during studies in mice in which these glycoproteins expressed together or singly by a recombinant vaccinia virus or a baculovirus were evaluated for their protective immunity against lethal dengue challenge. As an extension of the mouse protection studies, rhesus monkeys were immunized by (1) infection with a recombinant vaccinia virus expressing C-M-E-NS1-NS2a (group 1), (2) inoculation with a lysate of insect cells infected with a recombinant baculovirus expressing C-M-E-NS1-NS2a (group 2), (3) inoculation with a lysate of insect cells infected with a recombinant baculovirus expressing only E (group 3), (4) infection with a recombinant vaccinia virus expressing HIV envelope glycoprotein (group 4), and (5) inoculation with a lysate of insect cells infected with wild-type baculovirus (group 5). 1 of 6 monkeys in the 2nd group and 1 of 3 in the 3rd group were completely protected from dengue virus challenge as indicated by absence of viraemia. In addition, another monkey in the 2nd group was viraemic for 1 day as compared to monkeys in the control group whose viraemia lasted 4-6 days. On the other hand, monkeys in groups 1, 4 and 5 all became viraemic, and virus was recovered from blood for 4-6 days. These findings suggest that E with or without NS1 can induce partial protection against virus infection in experimental primates. Group-2 monkeys developed a high level of antibodies to NS1 in response to immunization with a baculovirus-recombinant-infected cell lysate containing E and NS1, but antibodies to E were not detected in the serum of group-2 or group-3 monkeys by RIP. However, some of these animals did develop a low titre of virion-specific antibodies detected by ELISA. Following challenge with virus, unprotected monkeys developed a rapid rise of E (groups 1, 2 and 3) and NS1 (groups 1 and 2) antibodies to a level higher than that attained initially by control monkeys, suggesting that immunization with recombinant-expressed E or E plus NS1, although not completely protective, did prime immunized monkeys for an accelerated immune response to these protective antigens. KW - Arboviruses KW - Immunization KW - Laboratory animals KW - Vaccines KW - Viral proteins KW - Baculovirus KW - Dengue virus KW - Flavivirus KW - Macaca mulatta KW - Baculoviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940502928&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Advances in the diagnosis of Pneumocystis carinii pneumonia. AU - Kovacs, J. A. T2 - Aids clinical review 1990. JO - Aids clinical review 1990. JF - Aids clinical review 1990. Y1 - 1990/// SP - 129 EP - 147 CY - New York; USA PB - Marcel Dekker Journals SN - 082478362X AD - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910875380. Publication Type: Miscellaneous. Language: English. Number of References: 55 ref. Subject Subsets: Protozoology N2 - The advances that have recently been made in diagnosing P. carinii pneumonia, including an understanding of which patients are at greatest risk for the development of P. carinii pneumonia, are reviewed. The diagnostic techniques that may be available in the future are briefly discussed. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - diagnosis KW - Human diseases KW - immunocompromised hosts KW - Opportunistic infections KW - parasites KW - reviews KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875380&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Management of fungal infections in patients with neoplastic diseases. AU - Walsh, T. J. AU - Pizzo, P. A. A2 - Ryley, J. F. T2 - Chemotherapy of fungal diseases. JO - Chemotherapy of fungal diseases. JF - Chemotherapy of fungal diseases. Y1 - 1990/// SP - 399 EP - 419 CY - Berlin; Germany PB - Springer-Verlag SN - 3540522328 AD - Walsh, T. J.: Infectious Diseases Section, Pediatrics Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19901207611. Publication Type: Miscellaneous. Language: English. Number of References: 84 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The treatment of fungal infections in patients with neoplastic diseases is reviewed. Management of nosocomial mycoses caused by Aspergillus flavus, A. fumigatus, agents of phycomycosis, Pseudallescheria boydii, Fusarium, agents of phaeohyphomycosis, Candida, Trichosporon beigelii and Malassezia furfur is included. KW - infections KW - neoplasms KW - phaeohyphomycosis KW - predisposition KW - therapy KW - zygomycosis KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Candida KW - Fusarium KW - Malassezia furfur KW - Man KW - Pseudallescheria boydii KW - Trichosporon beigelii KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Malassezia KW - Malasseziales KW - Ustilaginomycotina KW - Basidiomycota KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - cancers KW - chromomycosis KW - fungus KW - Hyphomycetes KW - phycomycosis KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901207611&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Cultivation of Entamoeba histolytica: a historical perspective. AU - Diamond, L. S. A2 - Kretschmer, R.R. T2 - Amebiasis: infection and disease by Entamoeba histolytica . Y1 - 1990/// CY - Boca Raton, Florida; USA PB - CRC Press Inc. SN - 0849353424 AD - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19900867284. Publication Type: Book chapter. Language: English. Number of References: 45 ref. Subject Subsets: Protozoology N2 - The historic technological developments in the cultivation of E. histolytica are reviewed in 3 sections: xenic, monoxenic and axenic culture, followed by a brief discussion of unsolved problems in its cultivation. KW - culture techniques KW - history KW - Human diseases KW - parasites KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900867284&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Ehrlichiosis. A vector-borne disease of animals and humans. A2 - Williams, J. C. A2 - Kakoma, I. T2 - Ehrlichiosis. A vector-borne disease of animals and humans. Y1 - 1990/// CY - 3300 AA Dordrecht: Kluwer Academic Publishers; Netherlands SN - 0792306910 AD - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19902207201. Publication Type: Conference proceedings; Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - The 12 papers in this book are based on a conference held in Washington, DC in December 1988, subsequently updated to incorporate research findings obtained in 1989. The chapters are: historical background and global importance of ehrlichiosis; in vitro cultivation of ehrlichiae; ultrastucture of rickettsiae with particular reference to ehrlichiae; antigenic properties of ehrlichiae and other rickettsiae; biological properties of the genus Ehrlichia; biological and pathogenic properties of E. risticii; pathophysiology of canine ehrlichiosis; experimental ehrlichiosis in nonhuman primates; human ehrlichiosis in the USA; evolutionary history of chlamydiae; recent research on cowdriosis; current research strategies on ehrlichiosis. KW - bacterial diseases KW - dog diseases KW - horse diseases KW - Zoonoses KW - Dogs KW - Ehrlichia KW - Ehrlichia canis KW - horses KW - Neorickettsia risticii KW - Rickettsiales KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Anaplasmataceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Ehrlichia KW - Equus KW - Equidae KW - Perissodactyla KW - Neorickettsia KW - bacterial infections KW - bacterioses KW - bacterium KW - Ehrlichia risticii KW - zoonotic infections KW - Animal Health and Hygiene (General) (LL800) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902207201&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immune responses in human hookworm infection. AU - Ottesen, E. A. A2 - Schad, G. A. A2 - Warren, K. S. T2 - Hookworm disease - current status and new directions. Y1 - 1990/// CY - London; UK PB - Taylor & Francis Ltd. SN - 0850667623 AD - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Building 10, Rm 11C108, Bethesda, MD 20215, USA. N1 - Accession Number: 19920878974. Publication Type: Book chapter. Language: English. Number of References: 32 ref. Subject Subsets: Helminthology N2 - An overview of the immune responses in human hookworm infection is given. The information is presented in 2 main sections: human immune responses to hookworms observed after experimental infections in volunteers; functional implications of the immune responses observed in human hookworm infection. KW - Eosinophils KW - helminths KW - Hookworms KW - Human diseases KW - immune response KW - Immunology KW - Lymphocytes KW - parasites KW - Ancylostomatidae KW - man KW - Nematoda KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - eosinophil leukocytes KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Molecular biology of Plasmodium. AU - McCutchan, T. F. A2 - Wyler, D. J. T2 - Modern parasite biology: cellular, immunological, and molecular aspects. Y1 - 1990/// CY - New York; USA PB - W. H. Freeman and Company SN - 0716720388\0716721406 AD - McCutchan, T. F.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910882447. Publication Type: Book chapter. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology N2 - This chapter discusses the role of molecular biology in the efforts to understand and eradicate malaria, and emphasizes molecular biology relating to diagnosis, taxonomy, genetics, gene analysis and vaccine production. KW - biology KW - biotechnology KW - malaria KW - molecular genetics KW - parasites KW - vaccines KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - biochemical genetics KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910882447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Visceral larva migrans and other unusual helminth infections. AU - Nash, T. E. A2 - Mandell, G. L. A2 - Douglas, R. G., Jr. A2 - Bennett, J. E. T2 - Principles and practice of infectious diseases. Y1 - 1990/// CY - New York; USA PB - Churchill Livingstone Inc. SN - 0443086869 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910871840. Publication Type: Book chapter. Language: English. Number of References: 40 ref. Subject Subsets: Helminthology N2 - Unusual helminth infections of man are discussed in this chapter with reference to the clinical significance of eosinophilia. The prevalence, clinical manifestations, diagnosis, treatment, management, and prevention of visceral larva migrans (toxocariasis) and anisakiasis are considered. Cutaneous larval migrans (creeping eruption), eosinophilic meningitis, abdominal angiostrongyliasis, dirofilariasis, capillariasis, and swimmer's itch are the other conditions included. KW - Developmental stages KW - helminths KW - Human diseases KW - infectious diseases KW - larva migrans KW - parasites KW - Anisakis KW - man KW - Nematoda KW - Toxocara canis KW - Anisakidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Toxocara KW - Ascarididae KW - Ascaridida KW - communicable diseases KW - creeping eruption KW - general account KW - growth phase KW - nematodes KW - parasitic worms KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871840&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Retrovirus biology and human disease. A2 - Gallo, R. C. A2 - Wong-Stall, F. T2 - Retrovirus biology and human disease. Y1 - 1990/// CY - New York, NY 10016; USA PB - Marcel Dekker, Inc. SN - 082477874X AD - National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19902206688. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - The purpose of this book is to describe some of the essential developments, both historical and current, relating to the retroviruses and the diseases they cause. The editors refer in the preface, to the tremendous amount of information on these viruses which has been obtained in the short time since their discovery and their link to disease. The emphasis is on the human T-leukaemia viruses (HTLVs) and the human immunodeficiency viruses (HIVs), but the book contains several chapters on animal retroviruses: feline leukaemia virus because it was the first transmissible, pathogenic leukaemia virus identified in nature; bovine leukaemia virus because of its many parallels and actual relationship to the HTLV; and the animal lentiviruses because of their relatonship to the HIVs. These papers are in the form of reviews, and it is possible that they have duplicated other reviews. However, it will serve a useful purpose in bringing all this information together. A quick scan revealed some printing errors and there seem to be a limited number of 1989 citations in the lists of references to these papers about the animal viruses. There is a short subject index. KW - bovine leukemia virus KW - Caprine arthritis encephalitis virus KW - Cats KW - Feline immunodeficiency virus KW - Gammaretrovirus KW - Lentivirus KW - Retroviridae KW - Visna/maedi virus KW - Deltaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - bovine leukaemia virus KW - Bovine oncovirus KW - Feline oncovirus KW - Lentivirinae KW - Visna maedi virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Animal Health and Hygiene (General) (LL800) KW - Pets and Companion Animals (LL070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19902206688&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Randomized clinical trials of weight reduction in nonhypertensive persons. AU - Cutler, J. A. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1991/// VL - 1 IS - 4 SP - 363 EP - 370 SN - 1047-2797 AD - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931458804. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - A review. Since 1987, 4 randomized, controlled clinical trials in the USA with 872 non-hypertensive subjects have produced results on weight-reducing interventions, involving decreased energy intake and/or increased energy expenditure, for effects on blood pressure (BP). The Hypertension Prevention Trial maintained a 3.5-kg net weight loss through 36 months with intake reduction alone. This programme decreased BP by 2.4/1.8 mm Hg (systolic/diastolic) compared with controls, but both weight loss and blood pressure changes were smaller when combined with decreased sodium intake. A Stanford University trial achieved weight losses of 7.4 and 5.1 kg over 12 months with diet and exercise, respectively. Effects on clinic BP were in the range of 1.5 to 3.0 mm Hg, and did not differ by intervention approach. The sole trial in children, conducted at the University of Michigan, found similar weight loss (about 7 kg) and BP effects from limiting energy intake over 20 weeks, regardless of inclusion of an exercise programme; the latter did, however, result in greater reductions in percentage body fat, heart rate and serum insulin level. The Primary Prevention of Hypertension trial tested a multifactor intervention, including reductions in weight (mean, 2.7 kg), sodium and alcohol intake, and increased physical activity. During a 5-year period, clinic BP was reduced by 2.0/1.9 mm Hg, and the incidence of hypertension by 52%. It is concluded that weight loss, however achieved, lowers BP in overweight, non-hypertensive persons, and probably can contribute substantially to reducing the incidence of hypertension. Whether there are independent effects additive to weight loss from increasing physical activity and reducing sodium intake remains unknown. KW - blood pressure KW - Obesity KW - reviews KW - weight reduction KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Workshop on obesity and blood pressure KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931458804&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet and the risk of in situ cervical cancer among white women in the United States. AU - Ziegler, R. G. AU - Jones, C. J. AU - Brinton, L. A. AU - Norman, S A. AU - Mallin, K. AU - Levine, R. S. AU - Lehman, H. F. AU - Hamman, R. F. AU - Trumble, A. C. AU - Rosenthal, J. F. AU - Hoover, R. N. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1991/// VL - 2 IS - 1 SP - 17 EP - 29 SN - 0957-5243 AD - Ziegler, R. G.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19921446058. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 50-81-7, 59-30-3, 68-26-8. Subject Subsets: Human Nutrition N2 - A case-control study of women with incident in situ and invasive cervical cancer was conducted during 1982-83 in 4 US areas reporting to the Comprehensive Cancer Patient Data System: Birmingham, Alabama; Chicago, Illinois; Denver, Colorado; Miami, Florida; and Philadelphia, Pennsylvania. Controls were selected by random-digit telephone dialing, and matched to invasive cases on age, race and telephone exchange. Of the white non-Hispanic in situ cases and controls identified, 229 (78%) and 502 (74%) were successfully interviewed. Diet was assessed by asking about the usual adult frequency of consumption of 75 food items and the use of vitamin supplements. Included were the major sources of the 4 micronutrients postulated to reduce the risk of cervical cancer: carotenoids, vitamin A, vitamin C and folate. Weak inverse associations between risk of in situ disease and intake of carotenoids, vitamin C, folate, fruit and vegetables/fruits were noted but, with further analysis, these seemed attributable to residual confounding by the multiple lifestyle-related risk factors for this disease and possibly to selection bias. Vitamin A and vegetable intake were unrelated to risk. Dark yellow-orange vegetable consumption and duration of multivitamin use were each strongly related to reduced risk of in situ disease (P for trend = 0.02 and 0.002, respectively). The absence of persuasive protect effects for the 4 micronutrients, and the similar findings from the analysis of invasive cervical cancer, do not concur with other epidemiologic studies, and suggest that the role of diet and nutrition in the aetiology of cervical cancer is not yet resolved. KW - ascorbic acid KW - Carcinoma KW - carotenoids KW - cervix KW - folic acid KW - fruit KW - intake KW - retinol KW - vegetables KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - folacin KW - folate KW - tetraterpenoids KW - United States of America KW - vegetable crops KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Laboratory confirmation of Lyme disease. AU - Schwan, T. G. AU - Simpson, W. J. AU - Rosa, P. A. JO - Canadian Journal of Infectious Diseases JF - Canadian Journal of Infectious Diseases Y1 - 1991/// VL - 2 IS - 2 SP - 64 EP - 69 SN - 1180-2332 AD - Schwan, T. G.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19920510378. Publication Type: Journal Article; Conference paper. Language: English. Language of Summary: French. Number of References: 56 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Lyme disease can be confirmed in the laboratory by isolation or detection of Borrelia burgdorferi, or by detecting a diagnostic change in the titre of antibodies specific to the spirochaete. B. burgdorferi can be isolated and cultivated in Barbour-Stoenner-Kelly II medium. It can be detected by light microscopy in tissue sections or, rarely, in blood smears using various staining methods. There is interest in the development of alternative detection methods, including identification of specific antigens of B. burgdorferi in the urine of suspected cases and demonstration of the presence of species-specific DNA using polymerase chain reaction assays. Currently, serological tests (indirect immunofluorescence assay, ELISA and Western immunoblot) are the most practical and available methods for confirming Lyme disease. KW - Antibodies KW - Antigens KW - Detection KW - diagnosis KW - ELISA KW - Human diseases KW - Immunoblotting KW - Immunofluorescence KW - Lyme disease KW - Borrelia burgdorferi KW - man KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - bacterium KW - enzyme linked immunosorbent assay KW - fluorescent antibody technique KW - IFAT KW - immunogens KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920510378&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mouse models of human diseases. AU - Westphal, H. JO - Current Opinion in Biotechnology JF - Current Opinion in Biotechnology Y1 - 1991/// VL - 2 IS - 6 SP - 830 EP - 833 SN - 0958-1669 AD - Westphal, H.: Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920195589. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Agricultural Biotechnology N2 - The use of transgenic mice as models for human diseases such as cancer, Alzheimer's disease and poliomyelitis is described. KW - animal models KW - Biotechnology KW - Human diseases KW - transgenics KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920195589&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Blastocystis hominis - past and future. AU - Zierdt, C. H. JO - Clinical Microbiology Reviews JF - Clinical Microbiology Reviews Y1 - 1991/// VL - 4 IS - 1 SP - 61 EP - 79 SN - 0893-8512 AD - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920884507. Publication Type: Journal Article. Language: English. Number of References: 95 ref. Subject Subsets: Protozoology; Public Health N2 - A review of B. hominis is provided. Major headings include: history; taxonomy; morphology; mitochondria; division in B. hominis; diagnosis; culture; surveys of intestinal parasites including B. hominis; clinical blastocystosis; effect of disease on large bowel mucosa; treatment. KW - human diseases KW - parasites KW - reviews KW - Blastocystis hominis KW - man KW - protozoa KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - blastocystosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920884507&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmaniasis vector potential of Lutzomyia spp. in Colombian coffee plantations. AU - Warburg, A. AU - Montoya-Lerma, J. AU - Jaramillo, C. AU - Cruz-Ruiz, A. L. AU - Ostrovska, K. JO - Medical and Veterinary Entomology JF - Medical and Veterinary Entomology Y1 - 1991/// VL - 5 IS - 1 SP - 9 EP - 16 SN - 0269-283X AD - Warburg, A.: A. Warburg, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910504548. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases N2 - Potential vectors of Leishmania braziliensis were assessed at 4 study sites in the mountainous Valle del Cauca, western Colombia, from March to June 1989. In an active focus of transmission at 1450 m altitude, a coffee plantation at Versalles, there were high densities of anthropophilic phlebotomines: Lutzomyia columbiana and L. townsendi, both in the L. verrucarum species group, and of L. pia. At a comparable altitude in a forest reserve at Yotoco where leishmaniasis is unknown, L. pia was the prevalent species and L. townsendi was absent. In 2 localities at 1150 m altitude, there were plentiful L. lichyi plus both species in the L. verrucarum group, but L. pia was absent. One of these localities, a coffee plantation at Villa Hermosa where a leishmaniasis outbreak occurred in 1986, was compared with a leishmaniasis-free, partly wooded nature reserve at Mateguadua. No natural infections of Leishmania were found in a total of 1896 wild-caught female phlebotomines belonging to at least 7 species. It remains unclear why leishmaniasis transmission is associated with coffee plantations in this part of Colombia. Laboratory-bred females were invariably autogenous, and blood-seeking females of this species were always parous. Parity rates in wild-caught females of other species were 55% Lutzomyia pia, 24% L. columbiana and 14% L. townsendi. Female Lutzomyia infected artificially with Leishmania braziliensis promastigotes developed peripylarian infections. Higher proportions of Lutzomyia townsendi (96%) and L. columbiana (78%) became infected but these species developed lower rates of stomodaeal infections (P < 0.1) than L. lichyi (37%) or L. pia (44%). Only 33% of a Colombian strain of L. longipalpis became infected. Combined evidence, from these laboratory and field studies, indicates that the sandfly species most strongly associated with leishmaniasis transmission in Colombian coffee plantations are L. columbiana and L. townsendi. Further work is required to clarify the local status of the other potential vector phlebotomines.<new para>ADDITIONAL ABSTRACT:<new para>Phlebotomine sandflies were collected on human bait from March to June 1989 at 4 sites in the Valle del Cauca region of western Colombia. Two sites were coffee plantations, where cases of cutaneous leishmaniasis caused by Leishmania braziliensis Viannia had occurred, and 2 were nature reserves. Eight Lutzomyia spp. were represented in the collections. The highest landing densities (78.9/man-h) were recorded at Versalles plantation (1450 m altitude), with Lutzomyia colombiana (Ritorcelli & Van Ty), Lu. townsendi (Ortiz) and Lu. pia (Fairchild & Hertig) predominant. In Yotoco forest reserve (1550 m), densities were much lower and Lu. pia predominated. At the Villa-Hermosa plantation (1150 m) and the Mateguadua reserve (1150 m, grassland and bush), densities were low and the predominant species was Lu. lichyi (Floch & Abonnenc), with a few Lu. colombiana and Lu. townsendi. Laboratory-bred Lu. lichyi were always autogenous in their first gonotrophic cycle, and all females caught at bait were parous. Parity rates of wild-caught females of other species were 24% for Lu. colombiana, 14% for Lu. townsendi and 55% for Lu. pia. No natural infections with Leishmania were found in 1896 females examined, but when wild-caught females were fed on cultured Le. braziliensis promastigotes, 25% of the Lu. colombiana, 26% of the Lu. townsendi, 37% of the Lu. lichyi and 44% of the Lu. pia developed stomadaeal infections; almost all of them developed pyloric infections. The vectors in the coffee plantations were probably Lu. colombiana and Lu. townsendi, but further work is needed to confirm this.J.E. Hudson KW - Autogeny KW - coffee KW - disease transmission KW - disease vectors KW - Ecology KW - epidemiology KW - Forests KW - habitats KW - infection KW - leishmaniasis KW - parasites KW - Parous rates KW - plantations KW - transmission KW - Vector competence KW - vectors KW - Colombia KW - South America KW - Coffea KW - Diptera KW - Leishmania braziliensis KW - Lutzomyia KW - Lutzomyia columbiana KW - Lutzomyia lichyi KW - Lutzomyia longipalpis KW - Lutzomyia pia KW - Lutzomyia townsendi KW - man KW - Phlebotominae KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Rubiaceae KW - Rubiales KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Lutzomyia KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - America (South) KW - coffee plantations KW - leishmaniosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504548&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary fiber and cancer prevention. AU - Shankar, S. AU - Lanza, E. JO - Hematology/Oncology Clinics of North America JF - Hematology/Oncology Clinics of North America Y1 - 1991/// VL - 5 IS - 1 SP - 25 EP - 41 SN - 0889-8588 AD - Shankar, S.: National Cancer Institute, The National Institutes of Health, 9000 Rockville Pike, Executive Plaza North, Room 212, Bethesda, MD 20892 6130, USA. N1 - Accession Number: 19921440269. Publication Type: Journal Article. Language: English. Number of References: 126 ref. Subject Subsets: Human Nutrition N2 - Epidemiologic, laboratory, and clinical metabolic research suggest that cancer risk can be reduced by a high intake of fibre-containing foods. Although there have been numerous reviews on the association between dietary fibre and colon cancer, more recent studies have also suggested an association with other gastrointestinal cancers, as well as cancers of the breast, ovary, and endometrium. Following a definition of fibre and its physiological effects, studies since 1980 for both colon and other cancers are reviewed. KW - Carcinoma KW - fibre KW - intake KW - prevention KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fiber KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440269&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antioxidant micronutrients in cancer prevention. AU - Dorgan, J. F. AU - Schatzkin, A. JO - Hematology/Oncology Clinics of North America JF - Hematology/Oncology Clinics of North America Y1 - 1991/// VL - 5 IS - 1 SP - 43 EP - 68 SN - 0889-8588 AD - Dorgan, J. F.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA. N1 - Accession Number: 19921440270. Publication Type: Journal Article. Language: English. Number of References: 209 ref. Subject Subsets: Human Nutrition N2 - A protective role for antioxidant micronutrients against cancer has been proposed on theoretical and experimental grounds. The antioxidant micronutrients carotenoids, vitamin C, vitamin E and selenium and their relation to cancer risk, are discussed. For each micronutrient, results of selected animal studies are briefly summarized, although a more comprehensive summary of results of studies in man is provided. KW - antioxidants KW - Carcinoma KW - prevention KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanisms of cancer cachexia. AU - Langstein, H. N. AU - Norton, J. A. JO - Hematology/Oncology Clinics of North America JF - Hematology/Oncology Clinics of North America Y1 - 1991/// VL - 5 IS - 1 SP - 103 EP - 123 SN - 0889-8588 AD - Langstein, H. N.: J. A. Norton, Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, Bethesda, MD 20892, USA. N1 - Accession Number: 19921440273. Publication Type: Journal Article. Language: English. Number of References: 107 ref. Subject Subsets: Human Nutrition N2 - The precise mechanism by which a cancer patient develops anorexia and progressive wasting, leading to body compositional changes associated with severe malnutrition remains largely unknown. The pathophysiology and the predominant changes in cancer patients and prevailing theories of the causes and mechanisms of these changes are discussed. KW - cachexia KW - Carcinoma KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440273&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmaniasis in a domestic goat in Kenya. AU - Williams, A. O. AU - Mutinga, J. AU - Rodgers, M. JO - Molecular and Cellular Probes JF - Molecular and Cellular Probes Y1 - 1991/// VL - 5 IS - 5 SP - 319 EP - 325 SN - 0890-8508 AD - Williams, A. O.: National Institutes of Health, Fogarty International Center, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878059. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Veterinary Science; Protozoology; Veterinary Science N2 - The pathological and electron-microscopic features of the first case of autochthonous leishmaniasis affecting a domestic goat in Kenya are described. Using a short amino-acid sequence common to all the species of Leishmania as primers for kDNA synthesis, the intervening sequence of 120 bases was amplified in the goat's tissues by polymerase chain reaction. The Leishmania kinetoplast DNA sequence was detected in all the different infected tissues. The sensitivity and specificity of this assay are discussed. The result of the assay used was consistent with the parasite being either L. major or L. aethiopica as the infecting agent. The isoenzyme studies were consistent with L. aethiopica as the strain responsible for this goat's infection. KW - Biotechnology KW - Case reports KW - DNA amplification KW - Leishmaniasis KW - Livestock KW - parasites KW - polymerase chain reaction KW - Protozoal infections KW - Techniques KW - Africa KW - Kenya KW - Bovidae KW - goats KW - Leishmania KW - protozoa KW - Ruminants KW - Sarcomastigophora KW - Trypanosomatidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Capra KW - Bovidae KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - East Africa KW - Africa South of Sahara KW - leishmaniosis KW - PCR KW - protozoal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878059&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of the immune response in lymphatic filariasis and onchocerciasis. AU - King, C. L. AU - Nutman, T. B. JO - Parasitology Today JF - Parasitology Today Y1 - 1991/// VL - 7 IS - 3 SP - A54 EP - A58 AD - King, C. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872996. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9008-11-1, 207137-56-2. Subject Subsets: Helminthology N2 - The roles of IL-4, IL-5 and γ-interferon in the induction of the immediate hypersensitivity response in human filarial infection are discussed with regard to: IgE responses; eosinophil responses; allergic responses; immunological tolerance to parasite antigens; the use of defined antigens to study parasite-specific immune responses; the effect of anti-parasite treatment on the immune response. KW - Cytokines KW - Filariids KW - helminths KW - Human diseases KW - immune response KW - interferon KW - interleukin 4 KW - interleukin 5 KW - parasites KW - Brugia malayi KW - man KW - Nematoda KW - Onchocerca volvulus KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - Wuchereria KW - immunity reactions KW - immunological reactions KW - Immunoparasitology KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872996&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular genetics of drug resistance in Plasmodium falciparum malaria. AU - Wellems, T. E. JO - Parasitology Today JF - Parasitology Today Y1 - 1991/// VL - 7 IS - 5 SP - 110 EP - 112 AD - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910875246. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 516-21-2, 58-14-0. Subject Subsets: Protozoology; Tropical Diseases N2 - The molecular basis of pyrimethamine and cycloguanil resistance in P. falciparum is described and genetic evidence that links chloroquine resistance to a single genetic locus in P. falciparum is reviewed. KW - Antimalarials KW - Antiprotozoal agents KW - chloroquine KW - cycloguanil KW - drug resistance KW - Molecular genetics KW - parasites KW - pyrimethamine KW - resistance KW - Resistance mechanisms KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - cycloguanil embonate KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875246&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Critical stages in the development of Plasmodium in mosquitoes. AU - Warburg, A. AU - Miller, L. H. JO - Parasitology Today JF - Parasitology Today Y1 - 1991/// VL - 7 IS - 7 SP - 179 EP - 181 AD - Warburg, A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910875273. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The fact that mammalian malarias are transmitted by anopheline mosquitoes, and avian malarias by culicine mosquitoes is examined with regard to current knowledge of development in the midgut; passage through the midgut epithelium, development in the haemocoel, and invasion of the salivary glands. Some documented cases of incompatible mosquito-Plasmodium combinations are cited. KW - development KW - disease vectors KW - Host parasite relationships KW - parasites KW - Vectors KW - Aedes KW - Anopheles KW - Apicomplexa KW - Culex KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - mosquitoes KW - parasite host relationships KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875273&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - trans Activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene. AU - Green, J. E. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1991/// VL - 11 IS - 9 SP - 4635 EP - 4641 SN - 0270-7306 AD - Green, J. E.: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19920192788. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Agricultural Biotechnology N2 - Three lines of transgenic mice containing the human T-cell lymphotropic virus type I (HTLV-I) tax gene develop neurofibromas composed of perineural fibroblasts. Tumours and tumour cell lines derived from these mice produce neurite outgrowth from PC-12 cells and nerve growth factor (NGF), as determined by blot analysis and enzyme-linked immunosorbent assay. In this study, in vitro cotransfection studies demonstrated that Tax protein is able to trans-activate the NGF promoter in NIH 3T3 fibroblast cells. The major cis-acting tax-responsive element in the NGF promoter (AGGGTGTGACGA) was shown to have 92% homology with a tax-responsive element contained within the 21-bp repeats of the HTLV-I long terminal repeat. The receptor for NGF was also expressed in the transgenic tumour cells, suggesting that Tax may activate an autocrine mechanisms through the upregulation of NGF. KW - Biotechnology KW - Central nervous system KW - Gene expression KW - Growth factors KW - HTLV infections KW - leukaemia KW - Molecular biology KW - nerve tissue KW - Regulation KW - transgenics KW - mice KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood cancer KW - CNS KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - leucaemia KW - leukemia KW - Tax KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920192788&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overexpression of transforming growth factor-β in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene. AU - Kim, S. J. AU - Winokur, T. S. AU - Lee, H. D. AU - Danielpour, D. AU - Kim, K. Y. AU - Geiser, A. G. AU - Chen, L. S. AU - Sporn, M. B. AU - Roberts, A. B. AU - Jay, G. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1991/// VL - 11 IS - 10 SP - 5222 EP - 5228 SN - 0270-7306 AD - Kim, S. J.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19920192718. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - The expression of the gene for transforming growth factor β1 (TGF-β1) was examined in transgenic mice carrying the tax gene for human T-cell leukaemia virus 1, which encodes a 40 kDa protein that is a potent transactivator of transcription directed by the viral long terminal repeat and of certain cellular genes. It was shown that tumours from these mice and other tissues, such as submaxillary glands and skeletal muscle, which express high levels of tax mRNA, selectively express high levels of TGF-β1 mRNA and protein. Moreover, TGF-β1 significantly stimulated the incorporation of tritiated thymidine into 1 of 3 cell lines derived from neurofibromas of tax-transgenic mice, which suggests that the excessive production of TGF-β1 may play a role in tumorigenesis, and that these mice may serve as a useful model for studying the biological effects of TGF-βin vivo. KW - Animal models KW - Biotechnology KW - gene expression KW - Genetic engineering KW - Growth factors KW - HTLV infections KW - leukaemia KW - Pathogenesis KW - transgenics KW - mice KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood cancer KW - genetic manipulation KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - leucaemia KW - leukemia KW - tax KW - Transforming growth factor-beta KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920192718&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Empiric therapy with amphotericin B in febrile granulocytopenic patients. AU - Walsh, T. J. AU - Lee, J. AU - Lecciones, J. AU - Rubin, M. AU - Butler, K. AU - Francis, P. AU - Weinberger, M. AU - Roilides, E. AU - Marshall, D. AU - Gress, J. AU - Pizzo, P. A. JO - Reviews of Infectious Diseases JF - Reviews of Infectious Diseases Y1 - 1991/// VL - 13 IS - 3 SP - 496 EP - 503 AD - Walsh, T. J.: Section of Infectious Diseases, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210555. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 49 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - Invasive fungal infection in granulocytopenic patients with neoplastic diseases, historical perspective and rationale for empiric use of amphotericin B, non-randomized and randomized studies of empiric amphotericin B, differential diagnosis, comprehensive approach to febrile granulocytopenic patients, limitations of empiric amphotericin B therapy and alternatives to amphotericin B in persistently febrile granulocytopenic patients are all discussed. KW - amphotericin B KW - Antifungal agents KW - Mycoses KW - predisposition KW - therapy KW - fungistats KW - granulocytopenia KW - Management of the immunocompromised patient KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210555&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retroviral vector-mediated in vivo expression of low-density-lipoprotein receptors in the Watanabe heritable hyperlipidemic rabbit. AU - Dichek, D. A. AU - Bratthauer, G. L. AU - Beg, Z. H. AU - Anderson, K. D. AU - Newman, K. D. AU - Zwiebel, J. A. AU - Hoeg, J. M. AU - Anderson, W. F. JO - Somatic Cell and Molecular Genetics JF - Somatic Cell and Molecular Genetics Y1 - 1991/// VL - 17 IS - 3 SP - 287 EP - 301 SN - 0740-7750 AD - Dichek, D. A.: Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19920196516. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Agricultural Biotechnology; Human Nutrition N2 - In this study, in vivo expression of recombinant low-density-lipoprotein (LDL) receptors was demonstrated in the Watanabe heritable hyperlipidaemic (WHHL) rabbit. A retroviral vector was constructed containing the human LDL receptor cDNA and was used to transduce primary skin fibroblasts from WHHL rabbits. The integrity and function of the introduced LDL receptor was established by immunoprecipitation, by a fluorescent LDL binding assay and by the ability of the transduced cells to suppress 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity in response to exogenous cholesterol. Autologous transduced fibroblasts were reimplanted into rabbit. In vivo LDL receptor expression and the survival of the transduced cells were analysed by immunohistochemistry and by LDL binding assay performed on cells recovered from the implants. LDL receptor-bearing cells could be identified on tissue sections and recovered from implants for up to 4 weeks. Total and LDL cholesterol levels decreased significantly after implantation of the transduced cells; however, control experiments indicated that the decreases were not mediated through the recombinant LDL receptor. While in vivo stable expression of recombinant LDL receptors in Watanabe rabbits is possible, consequent changes in lipid levels must be interpreted with caution. This system of site-specific in vivo expression of recombinant LDL receptors permits further evaluation of the role of LDL receptor-gene replacement in the therapy of hypercholesterolaemia. KW - animal models KW - Biotechnology KW - fibroblasts KW - Gene therapy KW - gene transfer KW - Hypercholesterolaemia KW - Hyperlipaemia KW - low density lipoprotein KW - receptors KW - retroviral vectors KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypercholesterinemia KW - hypercholesterolemia KW - hyperlipemia KW - in vivo KW - Low density lipoproteins KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920196516&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemistry of venom alkaloids in the ant genus Megalomyrmex. AU - Jones, T. H. AU - Blum, M. S. AU - Fales, H. M. AU - Brandão, C. R. F. AU - Lattke, J. JO - Journal of Chemical Ecology JF - Journal of Chemical Ecology Y1 - 1991/// VL - 17 IS - 9 SP - 1897 EP - 1908 SN - 0098-0331 AD - Jones, T. H.: Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517627. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Chemical analyses of 3 species in the Neotropical ant genus Megalomyrmex have identified this taxon as the 3rd myrmicine genus to produce alkaloids as major venom products. Workers of M. leoninus and workers and ergatoids of M. goeldii produce one or more of 4 trans-2,5-dialkylpyrrolidines previously identified in other myrmicine genera. M. modestus, on the other hand, is distinctive in producing the novel alkaloid (5E, 8E)-3-butyl-5-hexylpyrrolizidine, whose structure was established using a micro-Hofmann degradation sequence. The relationship of Megalomyrmex to other alkaloid-producing ant genera is discussed along with the possible chemotaxonomic significance of the analysed species when viewed in terms of the recognized species groups in this genus. KW - Alkaloids KW - Biochemistry KW - characterization KW - Chemotaxonomy KW - Toxins KW - venoms KW - Brazil KW - Venezuela KW - Formicidae KW - Hymenoptera KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Formicidae KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Andean Group KW - biochemical taxonomy KW - Megalomyrmex KW - Megalomyrmex goeldii KW - Megalomyrmex leoninus KW - Megalomyrmex modestus KW - Toxinology KW - venom KW - Plant Composition (FF040) KW - Taxonomy and Evolution (ZZ380) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517627&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemistry of venom alkaloids in the ant Megalomyrmex foreli (Myrmicinae) from Costa Rica. AU - Jones, T. H. AU - DeVries, P. J. AU - Escoubas, P. JO - Journal of Chemical Ecology JF - Journal of Chemical Ecology Y1 - 1991/// VL - 17 IS - 12 SP - 2507 EP - 2518 SN - 0098-0331 AD - Jones, T. H.: Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517531. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Chemical analysis of the venom of M. foreli from Cost Rica revealed the presence of 4 major alkaloidal components. 2 of these, 2-butyl-5-(E,1-heptenyl)-5-pyrroline and 2-butyl-5-(E,E,1,3-heptadienyl)-5-pyrroline, constitute a new functional class of ant venom alkaloids, whose structures were assigned from their spectral and chemical behaviour and unambiguous syntheses. The function of these compounds is suggested by field observations of the behaviour of M. foreli, its sting morphology and the relative toxicity of these 2 compounds against termite (Reticulitermes speratus) workers. KW - Alkaloids KW - Behaviour KW - Biochemistry KW - characterization KW - Morphology KW - Social insects KW - Sting apparatus KW - Toxicity KW - venoms KW - Central America KW - Costa Rica KW - Formicidae KW - Hymenoptera KW - Isoptera KW - Reticulitermes speratus KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Reticulitermes KW - Rhinotermitidae KW - Isoptera KW - Formicidae KW - America KW - CACM KW - Central America KW - Developing Countries KW - Latin America KW - Threshold Countries KW - behavior KW - Megalomyrmex KW - Megalomyrmex foreli KW - Toxinology KW - venom KW - Plant Composition (FF040) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lyme borreliosis: ten years after discovery of the etiologic agent, Borrelia burgdorferi. AU - Burgdorfer, W. JO - Infection JF - Infection Y1 - 1991/// VL - 19 IS - 4 SP - 257 EP - 262 SN - 0300-8126 AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA. N1 - Accession Number: 19950800132. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Since the recovery of its causative agent, B. burgdorferi, in 1981, Lyme borreliosis has become the most prevalent tickborne disease in the USA and Europe. The incidence of reported cases in the USA has increased from 2000 cases in 1987 to over 8000 in 1989. It occurs now in regions where the tick vectors, Ixodes dammini [I. scapularis] and I. pacificus, are absent and where other species of ticks may be responsible for maintaining and distributing the spirochaete. In Europe, Lyme borreliosis has been reported from 19 countries; its occurrence coincides with the distribution of I. ricinus. Specific and dependable serological tests are still not available, but development of probes for specific antigens and the polymerase chain reaction appear promising in detecting ongoing infection and in the identification of B. burgdorferi. Brief mention is made of advances in the development of whole cell and genetically engineered vaccines. KW - disease vectors KW - human diseases KW - immunodiagnosis KW - Lyme disease KW - reviews KW - tickborne diseases KW - vaccines KW - Europe KW - USA KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodidae KW - man KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - lyme borreliosis KW - serological diagnosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800132&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relationships of dietary fat consumption to serum total and low-density lipoprotein cholesterol in Hispanic preschool children. AU - Shea, S. AU - Basch, C. E. AU - Irigoyen, M. AU - Zybert, P. AU - Rips, J. L. AU - Contento, I. AU - Gutin, B. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1991/// VL - 20 IS - 2 SP - 237 EP - 249 SN - 0091-7435 AD - Shea, S.: Columbia University from the National Heart, Lung, and Blood Institute, Columbia University, Atchley Pavilion 1310, 161 Fort Washington Avenue, New York, NY 10032, USA. N1 - Accession Number: 19921443987. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The relation between dietary fat intake and serum lipids in 108 Hispanic children 4 to 5 years old was studied. Four 24-h recalls about 3 months apart and 2 Willett semiquantitative food frequency questionnaires about 6 months apart were obtained by interviewing the children's mothers. Children in the highest tertile of total fat consumption (36.2% of total energy) compared with the lowest tertile (30.2% of total energy) had a mean total serum cholesterol of 4.32 (167) vs. 3.91 mmol/litre (151 mg/100 ml) (test for linear trend across tertiles, P<0.05) and a mean low density lipoprotein cholesterol of 2.74 (106) vs. 2.29 mmol/litre (89 mg/100 ml) (test for linear trend, P<0.01). Children in the highest tertile of saturated fat consumption (14.6% of total energy) compared with the lowest tertile (11.2% of total energy) had a mean total serum cholesterol of 4.39 (170) vs. 3.97 mmol/litre (154 mg/100 ml) (test for linear trend, P<0.05) and a mean low-density lipoprotein cholesterol of 2.80 (108) vs. 2.35 mmol/litre (91 mg/100 ml) (test for linear trend, P<0.01). These relations remained significant when energy-adjusted nutrient intakes were examined and after adjustment in multiple linear regression models for age, sex, and body mass index, with the exception of the association of energy-adjusted total fat with total serum cholesterol (P=0.07). Similar results were obtained using the Willett questionnaires. Dietary fat, particularly saturated fat consumption, is an important correlate of blood lipid values in preschool children. These are the first reported data indicating that the Willett questionnaire, as a method for measuring the atherogenic components of diet, has criterion-related validity in young children. KW - blood KW - Children KW - cholesterol KW - ethnic groups KW - fats KW - intake KW - low density lipoprotein KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443987&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Host-parasite relationships of Ascogregarina chagasi (Eugregarinorida, Aseptatorina, Lecudinidae) in Lutzomyia longipalpis (Diptera: Psychodidae). AU - Warburg, A. AU - Ostrovska, K. JO - International Journal for Parasitology JF - International Journal for Parasitology Y1 - 1991/// VL - 21 IS - 1 SP - 91 EP - 98 SN - 0020-7519 AD - Warburg, A.: Medical Entomology Unit, Malaria Section, National Institutes of Health, Building 4, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871642. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The life cycle of A. chagasi in larvae and in adult female L. longipalpis was studied by light and electron microscopy. Sporozoites and young gamonts were attached to the epithelial lining of the larval midgut via an osmiophilic contact zone. The mucron of young gamonts was bordered by an invaginated pellicular fold, and an electron-opaque vesicular structure was observed adjacent to it. Sporozoites possessed an apical complex and were bound by a double membrane with underlying subpellicular microtubules. The gamont pellicle was uniformly corrugated and consisted of 2 cortical membranes and a plasma membrane. Mature gamonts and gametocysts were found in the posterior ectoperitrophic space of 3rd and 4th instar larval midguts and in the haemocoel of adult flies. Gametocysts in adult females adhered to the genital accessory glands, where they were encased in electron-dense capsules secreted by the fly through haemocyte-mediated humoral immune reactions. Oocytes were spindle-shaped and bound by a double-layered wall with a discernible polar plug at each end. Sporulation was endogenous, occurring within gametocysts in the midguts of larvae or the accessory glands of adult females. FITC-phalloidine staining of all stages of A. chagasi except mature gametocysts produced bright fluorescence, indicating the presence of a diffuse, actin-like protein in the cytoplasm. KW - Developmental stages KW - disease vectors KW - Electron microscopy KW - Entomopathogenic protozoa KW - entomopathogens KW - host parasite relationships KW - hosts KW - infections KW - natural enemies KW - parasites KW - pathogens KW - Vectors KW - Apicomplexa KW - Diptera KW - Lutzomyia longipalpis KW - Phlebotominae KW - protozoa KW - Psychodidae KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - insects KW - Hexapoda KW - arthropods KW - Lutzomyia KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Ascogregarina KW - Lecudinidae KW - Eugregarinorida KW - Ascogregarina chagasi KW - growth phase KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Biological Control (HH100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871642&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 1,25-Dihydroxyvitamin D3 receptors and resistance: implications in rickets, osteomalacia, and other conditions. AU - Marx, S. J. A2 - Glorieux, F. H. JO - Nestlé Nutrition Workshop Series JF - Nestlé Nutrition Workshop Series Y1 - 1991/// VL - 21 SP - 167 EP - 184 CY - New York; USA PB - Raven Press SN - 0742-2806 AD - Marx, S. J.: Mineral Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921450151. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Registry Number: 32222-06-3. Subject Subsets: Human Nutrition N2 - Defects in calcitriol receptors that disturb responsivity in tissues leading to rickets, osteomalacia and other conditions are reviewed. An overview of the normal structure, normal regulation and normal actions of calcitriol receptors is also given. KW - Bone diseases KW - calcitriol KW - Osteomalacia KW - receptors KW - reviews KW - Rickets KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - disorders KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921450151&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unusual aspects of allergic bronchopulmonary fungal disease: report of two cases due to Curvularia organisms associated with allergic fungal sinusitis. AU - Travis, W. D. AU - Kwon-Chung, K. J. AU - Kleiner, D. E. AU - Geber, A. AU - Lawson, W. AU - Pass, H. I. AU - Henderson, D. JO - Human Pathology JF - Human Pathology Y1 - 1991/// VL - 22 IS - 12 SP - 1240 EP - 1248 SN - 0046-8177 AD - Travis, W. D.: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211946. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp. and associated with allergic fungal sinusitis (AFS) are reported. C. lunata [Cochliobolus lunatus] was cultured from a 48-yr-old woman and Curvularia senegalensis from a 16-yr-old boy. Prominent follicular bronchiolitis and xanthomatous bronchiolitis were misleading histological features in the latter case and led to a delay in recognition of the diagnosis. Both patients presented primarily with AFS; ABPFD was detected subsequently. Based on these cases and a review of the literature, unusual clinical and pathological features that can occur in ABPFD are discussed. KW - allergies KW - hosts KW - infections KW - lungs KW - sinuses KW - USA KW - Cochliobolus lunatus KW - man KW - Pleosporaceae KW - Cochliobolus KW - Pleosporaceae KW - Pleosporales KW - Dothideomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Curvularia KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Curvularia senegalensis KW - fungus KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211946&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma pharmacokinetics and tissue penetration of a novel antifungal triazole, Bay R 3783, and its long-lasting active metabolite, Bay U 3625, in rabbits. AU - Lee, J. W. AU - Ritter, W. AU - Lecciones, J. AU - Kelly, P. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Antimicrobial Chemotherapy JF - Journal of Antimicrobial Chemotherapy Y1 - 1991/// VL - 27 IS - 6 SP - 837 EP - 844 SN - 0305-7453 AD - Lee, J. W.: Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19911210535. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The plasma pharmacokinetics and tissue penetration of Bay R 3783 (BR), a new antifungal triazole, and one of its active metabolites, Bay U 3625 (BU), were studied in rabbits. Plasma levels of BR and BU were determined simultaneously in 5 rabbits for 6 d after a single oral dose of 20 or 40 mg/kg BR. For BR, the mean Cmax was 1.9±0.4 mg/litre, Tmax 2.0±0.7 h, AUC∞ 7.5±1.6 mg per h/litre and terminal plasma T1/2 2.1±0.1 h. For BU, the mean Cmax was 0.84±0.09 mg/litre, Tmax 24±4 h, the AUC∞ 61.9±6.5 mg per h/litre and the plasma T1/2 was 48±3 h. In a multi-dose study, the plasma BR clearance during wash-out gradually diminished, indicating possible metabolite inhibition of BRs biotransformation. No hepatic or renal toxicity was seen after 28 d of dosing with BR 40 mg/kg per d. Both BR and BU penetrated well into tissues, with tissue drug concn over 3 times higher than in plasma at multiple tissue sites. Persistence of BU in plasma, however, resulted in prolonged, higher tissue levels of BU than of BR. It is concluded that BR is converted to a long-lasting active metabolite BU, that persistence of BU in tissue is prolonged and that these properties may permit BU to contribute significantly to the antifungal activity of BR. KW - Antifungal agents KW - pharmacokinetics KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Bay R 3783 KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210535&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transport of fatty acids and monoacylglycerols in white and brown adipose tissues. AU - Scow, R. O. AU - Blanchette-Mackie, E. J. JO - Brain Research Bulletin JF - Brain Research Bulletin Y1 - 1991/// VL - 27 IS - 3/4 SP - 487 EP - 491 SN - 0361-9230 AD - Scow, R. O.: National Institutes of Health, Building 6, Room 137, Bethesda, MD 20892, USA. N1 - Accession Number: 19931461187. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition N2 - The manner in which fatty acids and monacylglycerols are transported in white and brown adipose tissues is the subject of this review. KW - Adipose tissue KW - fatty acids KW - monoacylglycerols KW - reviews KW - transport KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - monoglycerides KW - transportation KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461187&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of a restriction fragment length polymorphism (RFLP) as a genetic marker in crosses of Anopheles gambiae (Diptera: Culicidae): independent assortment of a diphenol oxidase RFLP and an esterase locus. AU - Romans, P. AU - Seeley, D. C. AU - Kew, Y. AU - Gwadz, R. W. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1991/// VL - 28 IS - 1 SP - 147 EP - 151 SN - 0022-2585 AD - Romans, P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910505292. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Analysis of restriction fragment length polymorphism (RFLP) is a powerful tool for analysing linkage relationships in species where few genetic markers have been described and where conduct of crosses is difficult. It also permits integration of genetic and physical (cytogenetic) data when the probes have been mapped by in situ hybridization. To illustrate the utility of the method, and because some mutations of a diphenol oxidase gene might conceivably produce the malaria refractoriness phenotype of ookinete-oocyst encapsulation, backcrosses between 2 inbred lines of A. gambiae were carried out to determine the linkage relationship between the diphenol oxidase A2 (Dox) gene and the esterase locus associated with refractoriness to Plasmodium cynomolgi NIH. The Dox alleles were a Sal I RFLP visualized by probing Southern blotted DNA from portions of individual mosquitoes with a cloned Dox gene probe. The 2 genes were shown to segregate independently. KW - disease vectors KW - DNA probes KW - Enzymes KW - Genes KW - genetic markers KW - genetics KW - Human diseases KW - Linkage KW - Molecular genetics KW - parasites KW - restriction fragment length polymorphism KW - susceptibility KW - vectors KW - Anopheles gambiae KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodium cynomolgi KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - mosquitoes KW - refractoriness KW - RFLP KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910505292&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals. AU - Simpson, W. J. AU - Burgdorfer, W. AU - Schrumpf, M. E. AU - Karstens, R. H. AU - Schwan, T. G. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1991/// VL - 29 IS - 2 SP - 236 EP - 243 SN - 0095-1137 AD - Simpson, W. J.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19910504929. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi expresses a conserved, species-specific 39-kDa protein (P39) that can stimulate antibodies during human infection. To confirm that anti-P39 antibodies are produced consistently in animals exposed to infectious spirochaetes, white-footed mice (Peromyscus leucopus) and laboratory white mice (Mus musculus, strain BALB/c) were experimentally inoculated with either infectious or non-infectious B. burgdorferi and the antibody response to P39 was determined by immunoblot at 21 days post-inoculation. All mice inoculated with approximately 107 infectious B. burgdorferi produced anti-P39 antibodies and were cultured positive for this spirochaete. Mice inoculated with similar numbers of inactivated or viable non-infectious B. burgdorferi still producing P39 did not induce anti-P39 antibodies. By contrast, putative antiflagellin antibodies were detected in <18% of the infected animals, which supports the notion that antibody reactive with flagellin may not be reliable as a marker for B. burgdorferi exposure as was originally thought. Mice infected with B. burgdorferi following exposure to ticks (Ixodes dammini) produced anti-P39 antibodies no later than 7 days post-infection, indicating that P39 is an effective immunogen in natural infections. Notably, anti-P39 antibodies were the predominant B. burgdorferi reactive antibodies detected early in the infection. Results indicated that anti-P39 antibodies are produced in response to an active infection and are therefore reliable markers for infection in experimentally and naturally inoculated animals. KW - antibodies KW - disease transmission KW - disease vectors KW - Immune response KW - Immunization KW - Immunology KW - infection KW - Laboratory animals KW - Lyme disease KW - Tickborne diseases KW - transmission KW - vectors KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodes scapularis KW - Ixodidae KW - Mice KW - Peromyscus leucopus KW - rodents KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Peromyscus KW - Sigmodontinae KW - bacterium KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - Ixodes dammini KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504929&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rapid method to extract DNA from Cryptococcus neoformans. AU - Varma, A. AU - Kwon-Chung, K. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1991/// VL - 29 IS - 4 SP - 810 EP - 812 SN - 0095-1137 AD - Varma, A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19911208798. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology N2 - A rapid and easy method for the extraction of total cellular DNA from C. neoformans is described. This procedure modifies and considerably simplifies previously reported methods. Numerous steps were either eliminated or replaced, including preincubations with cell wall permeability agents such as β-mercaptoethanol and dithiothreitol. The commercially available enzyme preparation Novozyme 234 was found to contain a potent concn of DNases which actively degrade DNA. Degradation and loss of DNA was prevented by maintaining a high concn of EDTA in the lysing solution. This procedure resulted in high yields (150-200 µg of DNA from 100 ml of culture) of good-quality (undegraded), high-molecular-weight DNA which was readily digested by restriction endonucleases, making it suitable for use in various molecular applications. KW - DNA KW - extraction KW - genetics KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - deoxyribonucleic acid KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208798&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dual tracer stable isotopic assessment of calcium absorption and endogenous fecal excretion in low birth weight infants. AU - Abrams, S. A. AU - Esteban, N. V. AU - Vieira, N. E. AU - Yergey, A. L. JO - Pediatric Research JF - Pediatric Research Y1 - 1991/// VL - 29 IS - 6 SP - 615 EP - 618 SN - 0031-3998 AD - Abrams, S. A.: 9000 Rockville Pike, Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bldg. 10, Rm. 6C-101, Bethesda, MD 20892, USA. N1 - Accession Number: 19921440067. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition N2 - Using a dual tracer (44Ca orally and 46Ca intravenously) stable isotope technique, true dietary calcium absorption, endogenous faecal Ca excretion, and net Ca retention were measured in 12 low birth weight (1426±260 g) infants fed a high Ca-containing formula. Endogenous faecal Ca excretion averaged 7.2±4.1% of intake, and exceeded 10% of intake in 3 infants. Net Ca retention, 103±38 mg kg-1day,-1 was consistent with previous studies of Ca retention obtained using mass balance techniques and correlated closely (r=0.98, P<0.001) with true Ca absorption but not with endogenous faecal excretion (r=-0.40, P=0.19). Although endogenous faecal excretion may represent a significant source of Ca loss for some low birth weight infants, these data suggest that net Ca retention in low birth weight infants fed a high Ca-containing formula is primarily determined by the total dietary Ca absorbed. KW - birth weight KW - calcium KW - calcium absorption KW - excretion KW - Infants KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440067&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune capture and detection of Borrelia burgdorferi antigens in urine, blood, or tissues from infected ticks, mice, dogs, and humans. AU - Dorward, D. W. AU - Schwan, T. G. AU - Garon, C. F. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1991/// VL - 29 IS - 6 SP - 1162 EP - 1170 SN - 0095-1137 AD - Dorward, D. W.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19920511667. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science N2 - A rapid and sensitive assay was developed for B. burgdorferi antigens in infected hosts. Polyclonal rabbit antisera were raised against membrane vesciles and an 83-kDa vesicle-associated protein band that was purified from in vitro B. burgdorferi cultures. IgG antibodies were recovered from these sera and tested for a species-specific reaction with several geographically diverse Borrelia isolates by immunoblot analysis. Parlodion-coated electron microscope grids were activated with anti-vesicle F(ab′)2 fragments and then incubated with confirmed or experimental sources of spirochaetal antigens. Such sources included cultured spirochaetes; spirochaete culture supernatants; samples of urine, blood or serum from mice, dogs and humans; triturates of Ixodes ticks; and bladder, spleen, liver, kidney, heart or brain tissues from infected or control mice. Captured antigens were assayed by immune electron microscopy by using anti 83-kDa IgG antibodies and protein A-colloidal gold conjugates. The results indicated that B. burgdorferi appears to shed surface antigens which are readily detectable in urine, blood and several organs from infected hosts. Such antigens were detectable in mouse urine at dilutions exceeding 10-6. Intact spirochaetes were frequently observed on grids incubated with blood, spleen or bladder preparations, and B. burgdorferi was reisolated from the urinary bladders of all experimentally infected mice. These results indicated that B. burgdorferi antigens arise in a variety of host materials. Such antigens can be captured and identified with specific polyclonal antibodies, providing a sensitive assay for monitoring and studying Lyme borreliosis. KW - Antibodies KW - antigens KW - bacterial diseases KW - detection KW - Diagnostic techniques KW - Disease vectors KW - Human diseases KW - IgG KW - immunoassay KW - Immunodiagnosis KW - Immunoglobulins KW - immunology KW - Lyme disease KW - Tickborne diseases KW - California KW - Connecticut KW - Europe KW - France KW - Germany KW - New York KW - North America KW - Rhode Island KW - USA KW - Washington KW - Borrelia burgdorferi KW - Dogs KW - Ixodes scapularis KW - Ixodidae KW - Man KW - Mice KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - Homo KW - Hominidae KW - Primates KW - Muridae KW - rodents KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - New England States of USA KW - Northeastern States of USA KW - European Union Countries KW - Mediterranean Region KW - Western Europe KW - Europe KW - Middle Atlantic States of USA KW - Pacific Northwest States of USA KW - antigenicity KW - bacterial infections KW - bacterioses KW - bacterium KW - gamma-globulins KW - immune globulins KW - immunogens KW - Ixodes dammini KW - lyme borreliosis KW - serological diagnosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511667&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular and immunological analysis of a polymorphic periplasmic protein of Borrelia burgdorferi. AU - Simpson, W. J. AU - Schrumpf, M. E. AU - Hayes, S. F. AU - Schwan, T. G. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1991/// VL - 29 IS - 9 SP - 1940 EP - 1948 SN - 0095-1137 AD - Simpson, W. J.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19920511684. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology N2 - To assist in the categorization and typing of fresh B. burgdorferi isolates from global foci, a unique species-specific periplasmic protein (P22-A) conserved among all North American and European isolates was identified. The gene encoding this antigen was cloned and the recombinant was used to screen serum collected from experimentally infected animals. Although antibodies were detected in all infected animals at 21 days after inoculation with live, low-passage spirochaetes, the response was stronger in other animals that were inoculated with inactivated and lysed bacteria. This result, along with the immune electron microscopy data, suggests P22-A is concentrated in the periplasmic space. The P22-A antigens exhibited size heterogeneity among different isolates, ranging between 20 and 23 kDa, but as a group the P22-A antigens appeared to retain antigenic homogeneity. Thus, P22-A can serve as a structural marker for characterizing new isolates of B. burgdorferi and may prove useful in future serological assays with a mixture of B. burgdorferi-specific antigens. KW - Antigens KW - Human diseases KW - Lyme disease KW - molecular genetics KW - proteins KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - biochemical genetics KW - immunogens KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511684&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of flaviviruses by reverse-transcriptase polymerase chain reaction. AU - Eldadah, Z. A. AU - Asher, D. M. AU - Godec, M. S. AU - Pomeroy, K. L. AU - Goldfarb, L. G. AU - Feinstone, S. M. AU - Levitan, H. AU - Gibbs, C. J., Jr. AU - Gajdusek, D. C. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1991/// VL - 33 IS - 4 SP - 260 EP - 267 SN - 0146-6615 AD - Eldadah, Z. A.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517843. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases N2 - RNA sequences of 5 flaviviruses were detected by a modified polymerase chain reaction (PCR) that incorporated a reverse transcriptase and RNAase inhibitor. Oligonucleotide primer pairs were synthesized to amplify sequences from St. Louis encephalitis, Japanese encephalitis, yellow fever, dengue 2 and dengue 4 viruses. The amplified products were visualized as bands of appropriate size on ethidium bromide-stained agarose gels. The identity of these products was confirmed by restriction endonuclease cleavage to generate fragments of predicted lengths. The reverse-transcriptase PCR (RT-PCR) successfully amplified flavivirus sequences from cell cultures, frozen brain tissue and formalin-fixed, paraffin-embedded brain tissue. The reactions were highly specific, and the method compared favourably to 2 conventional assays of viral infectivity. RT-PCR followed by PCR with nesting primers was 1000-fold more sensitive in detecting virus than classical infectivity titration by intracerebral inoculation of suckling mice and nearly 1000-fold more sensitive than amplification of virus in cell culture followed by inoculation of mice. KW - Arboviruses KW - detection KW - Diagnosis KW - Diagnostic techniques KW - polymerase chain reaction KW - RNA KW - Dengue virus KW - Flavivirus KW - Japanese encephalitis virus KW - St Louis encephalitis virus KW - St. Louis encephalitis virus KW - Yellow fever virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - PCR KW - ribonucleic acid KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517843&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathogens of phlebotomine sandflies: a review. AU - Warburg, A. AU - Ostrovska, K. AU - Lawyer, P. G. A2 - Maroli, M. JO - Parassitologia (Roma) JF - Parassitologia (Roma) Y1 - 1991/// VL - 33 IS - Suppl. 1 SP - 519 EP - 526 SN - 0048-2951 AD - Warburg, A.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Building 4, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517068. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology; Biocontrol N2 - The pathogens of phlebotomine sandflies are reviewed under the headings: viruses; bacteria; protozoa; fungi; nematodes; mites. The potential of these different pathogens as biological control agents of sandflies is briefly discussed. KW - Biological control agents KW - Entomogenous fungi KW - Entomopathogenic bacteria KW - Entomopathogenic protozoa KW - entomopathogens KW - Entomophilic nematodes KW - hosts KW - Insect viruses KW - natural enemies KW - pathogens KW - reviews KW - Acari KW - Diptera KW - Nematoda KW - Phlebotominae KW - Psychodidae KW - entomopathogens KW - animal viruses KW - viruses KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - insects KW - Hexapoda KW - Psychodidae KW - Diptera KW - biocontrol agents KW - biological control organisms KW - entomopathogenic fungi KW - fungus KW - insect nematodes KW - viruses of insects KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biological Control (HH100) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517068&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins. AU - Cabib, E. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1991/// VL - 35 IS - 1 SP - 170 EP - 173 SN - 0066-4804 AD - Cabib, E.: Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19911208077. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 11113-80-7. Subject Subsets: Medical & Veterinary Mycology N2 - Polyoxin D, nikkomycin X and nikkomycin Z are all competitive inhibitors of chitin synthetase 2 (Chs2), the essential enzyme for primary septum formation in Saccharomyces cerevisiae, and of Chs1, a repair enzyme. However, Chs2 is more resistant to these antibiotics than Chs1. When Co2+, the best stimulator of Chs2, was used in the assay for this enzyme, the differences in the Kivalues for nikkomycins between the 2 isozymes reached 3 orders of magnitude. These results indicated differences in the active sites of the 2 isozymes. Polyoxin D was much more effective than nikkomycin Z in inhibiting cell growth. The importance of the choice of enzyme and of assay conditions when cell wall-synthesizing enzymes are used in screens for possible antifungal agents is noted. KW - antifungal agents KW - antifungal properties KW - nikkomycins KW - pharmacodynamics KW - polyoxins KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Saccharomyces KW - Saccharomycetaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - anti-fungal properties KW - drug action KW - fungicidal properties KW - fungistats KW - fungus KW - mechanism of drug action KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208077&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography. AU - Rex, J. H. AU - Hanson, L. H. AU - Amantea, M. A. AU - Stevens, D. A. AU - Bennett, J. E. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1991/// VL - 35 IS - 5 SP - 846 EP - 850 SN - 0066-4804 AD - Rex, J. H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19911209170. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - An improved bioassay for fluconazole using Candida kefyr was developed. This assay is sensitive in the clinically relevant range (2-40 µg/ml) and analyses plasma, serum and cerebrospinal fluid specimens; bioassay results correlate with results obtained by HPLC. Bioassay and HPLC analyses of spiked plasma, serum and cerebrospinal fluid samples (run as unknowns) gave good agreement with expected values. Analysis of specimens from patients gave equivalent results by both HPLC and bioassay. HPLC had a lower within-run coefficient of variation (<2.5% for HPLC vs. <11% for bioassay) and a lower between-run coefficient of variation (<5% vs. <12% for bioassay) and was more sensitive (lower limit of detection, 0.1 µg/ml vs. 2 µg/ml for bioassay). It is concluded that the bioassay is, however, sufficiently accurate and sensitive for clinical specimens, and its relative simplicity, low sample volume requirement, and low equipment cost should make it the technique of choice for analysis of routine clinical specimens. KW - antifungal agents KW - antifungal properties KW - bioassays KW - estimation KW - Fluconazole KW - liquid chromatography KW - Candida kefyr KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii in pleural fluid. The cytologic appearance. AU - Elwood, L. J. AU - Dobrzanski, D. AU - Feuerstein, I. M. AU - Solomon, D. JO - Acta Cytologica JF - Acta Cytologica Y1 - 1991/// VL - 35 IS - 6 SP - 761 EP - 764 SN - 0001-5547 AD - Elwood, L. J.: Cytopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19920881207. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology N2 - The cytological appearance of Pneumocystis carinii in pleural fluid is described. The diagnosis of P. carinii infection was made by examination of air-dried, modified Wright-Giemsa (Diff-Quik)- stained Cytospin preparations of the pleural fluid from a patient with acquired immunodeficiency syndrome. The diagnostic appearances of P. carinii stained by this method and by the Papanicolaou stain are reviewed. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - cytology KW - diagnosis KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881207&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-β-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis. AU - Walsh, T. J. AU - Lee, J. W. AU - Kelly, P. AU - Bacher, J. AU - Lecciones, J. AU - Thomas, V. AU - Lyman, C. AU - Coleman, D. AU - Gordee, R. AU - Pizzo, P. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1991/// VL - 35 IS - 7 SP - 1321 EP - 1328 SN - 0066-4804 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19911210185. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 79404-91-4. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of its linear and nonlinear pharmacokinetics were studied during continuous versus intermittent intravenous infusion of cilofungin in the treatment of experimental disseminated candidosis in persistently granulocytopenic rabbits. Six groups of rabbits were studied, untreated controls (n=32) and 5 cilofungin dosage regimen groups consisting of the following: 25 mg/kg of body wt intravenously twice daily (VLoINT) (n=9); 50 mg/kg twice daily (LoINT) (n=9); 90 mg/kg twice daily (HiINT) (n=11); 5 mg/kg per h for 18 h/d (LoCI) (n=7) and 10 mg/kg per h for 18 h/d (HiCI) (n=7). All regimens achieved plasma concn exceeding the min. inhibitory concn (MIC) for Candida albicans (0.25 µg/ml). In vitro timed kill assays found that the fungicidal activity and rate of kill by cilofungin above the MIC for C. albicans was concn dependent. At the lower dosage regimens (VLoINT, LoINT and LoCI), cilofungin followed linear plasma pharmacokinetics, whereas at higher doses (HiCI and HiINT), nonlinear kinetics consistent with a saturated elimination pathway(s) were observed. Only HiCI and HiINT produced a 10³- to 104-fold reduction in colony forming units/g in candidosis of the brain (P≤0.001). HiCI and HiINT also significantly reduced infection in the choroid (P≤0.05). All regimens, except VLoINT, significantly (P≤0.01) reduced tissue infections in lung, liver, spleen and kidney. However, only the regimens with nonlinear saturation kinetics (HiCI and HiINT) produced a 106 reduction in the spleen and a >105 reduction of C. albicans in the kidney and liver. A simple doubling of the dosage from LoCI to HiCI resulted in tissue concn that were 10 times higher and a 10²- to 104-fold greater antifungal effect. There was a direct correlation (r²=0.83) between tissue concn of cilofungin and antifungal activity. It is concluded that continuous and intermittent infusion dosage regimens that elicit nonlinear saturation plasma pharmacokinetics of cilofungin are associated with increased antifungal activity against experimental disseminated candidosis. KW - Antifungal agents KW - Cilofungin KW - generalized infections KW - infections KW - pharmacokinetics KW - therapy KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210185&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of low-dose trimethoprim-sulfamethoxazole thrice weekly for primary and secondary prophylaxis of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients. AU - Stein, D. S. AU - Stevens, R. C. AU - Terry, D. AU - Laizure, S. C. AU - Palte, S. AU - Lancaster, D. J. AU - Weems, J. J. AU - Williams, C. L. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1991/// VL - 35 IS - 9 SP - 1705 EP - 1709 SN - 0066-4804 AD - Stein, D. S.: Treatment Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, 6003 Executive Boulevard, Room 204-P, Rockville, MD 20852, USA. N1 - Accession Number: 19920876605. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology N2 - An open prospective clinical trial to evaluate the efficacy and toxicity of trimethoprim-sulfamethoxazole given as one double-strength tablet thrice weekly for primary and secondary prophylaxis of P. carinii pneumonia (PCP) to HIV-infected (HIV+) patients from Tennessee, USA, was conducted. A total of 104 HIV+ patients were evaluated, with 74 being in the primary prophylaxis group and 30 being in the secondary prophylaxis group. All except 6 patients received concomitant zidovudine; 5 patients on primary prophylaxis and one patient on secondary prophylaxis refused zidovudine. There were 70 patients evaluated for the efficacy of primary prophylaxis. The mean CD4 count was 124.4±110.1 cells/µl. The mean follow-up time was 11.8±5.8 months (median, 12 months; range, 1 to 32 months). Two non-compliant patients developed PCP after one and 3 months of chemoprophylaxis. The failure rate (under the intention to treat principle) was 2 of 70 patients (2.9%), or one per 413 patient-months of observation. There were 27 patients evaluated for the efficacy of secondary prophylaxis. The mean follow-up time was 12.4±7.2 months (median, 11 months; range, one to 29 months). Two patients, one of whom was noncompliant, were treatment failures, developing PCP after 14 and 15 months of chemoprophylaxis; this gave a failure rate of 2 of 27 patients (7.4%), or one per 167 patient-months of observation. Adverse reactions sufficient to permanently terminate therapy occurred in 9 of 104 patients (8.7%) overall. The serum trimethoprim, sulfamethoxazole, and N4-acetylsulfamethoxazole concentrations measured by HPLC were uniformly low. One double-strength tablet of trimethoprim-sulfamethoxazole taken weekly on Monday, Wednesday, and Friday appeared to be well tolerated and efficacious for the prophylaxis of PCP in HIV+ patients at high risk and deserves further investigation. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Antiprotozoal agents KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - prophylaxis KW - North America KW - Tennessee KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - Appalachian States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - East South Central States of USA KW - AIDS KW - fungus KW - human immunodeficiency virus KW - Trimethoprim sulfamethoxazole KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876605&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A serum-free, partly defined medium, PDM-805, for axenic cultivation of Entamoeba histolytica Schaudinn, 1903 and other Entamoeba. AU - Diamond, L. S. AU - Cunnick, C. C. JO - Journal of Protozoology JF - Journal of Protozoology Y1 - 1991/// VL - 38 IS - 3 SP - 211 EP - 216 AD - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920874321. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The first serum-free, partly defined medium (PDM-805) for cultivating E. histolytica, E. barreti, E. invadens, and E. terrapinae, is described. PDM-805 was developed by the stepwise replacement of yeast extract, bovine serum, and a casein peptone digest in TYI-S-33, a medium widely used for the axenic cultivation of these parasites. The defined components include amino acids, carbohydrates, B vitamins, ascorbic acid, tocopherol, thioctic acid, nucleic acid precursors, trace metals, and phosphate buffers. The undefined components include a highly purified bovine serum albumin, a lipoprotein-cholesterol solution from bovine serum, and a dialyzable, autoclavable, water-soluble growth factor(s) having a molecular weight of less than 3 500 prepared from casein peptone. To date, studies on the growth requirements of E. histolytica, strain 200:NIH, show the following are essential for sustained multiplication of this amoeba: iron, glucose, biotin, folic acid, niacinamide, pantothenate, pyridoxal, riboflavin, thiamine, cysteine, an ammonium moiety (in addition to that present in cysteine), bovine serum albumin, lipoprotein-cholesterol, and casein peptone dialysate.<new para>ADDITIONAL ABSTRACT:<new para>This paper describes the preparation and composition of a serum-free medium for the cultivation of Entamoeba histolytica (3 strains) and 3 species of reptilian Entamoeba (at 35.5 °C and 24.0 °C respectively). [The original paper should be consulted for full details.] The medium (PDM-805) was a complex mixture of buffers, inorganic salts, trace metals, amino acids, carbohydrates, nucleic-acid precursors, vitamins, sodium acetate, detergent (Tween 80), and 3 undefined components: purified bovine serum albumin, casein peptone dialysate, and a lipoprotein-cholesterol solution prepared from bovine serum. In this medium Ent. histolytica multiplied about 35-fold after 100 h.J.R. Baker KW - culture media KW - culture techniques KW - Human diseases KW - parasites KW - Endamoebidae KW - Entamoeba KW - Entamoeba histolytica KW - Entamoeba invadens KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Endamoebidae KW - Entamoeba KW - Entamoeba barreti KW - Entamoeba terrapinae KW - media KW - serum free media KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920874321&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trypanosoma cruzi: flow cytometric analysis of developmental stage differences in DNA. AU - Nozaki, T. AU - Dvorak, J. A. JO - Journal of Protozoology JF - Journal of Protozoology Y1 - 1991/// VL - 38 IS - 3 SP - 234 EP - 243 AD - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920874325. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology; Tropical Diseases N2 - Flow cytometry and DNA binding-specific fluorescent reagents were used to compare the total DNA, G-C, and A-T content of the epimastigote and trypomastigote stages of T. cruzi stocks. Significant total DNA differences of 2-12% between epimastigotes and trypomastigotes were found in 3 of 6 stocks studied. The epimastigote G-C content of 5 of 6 stocks were 4-8% higher than trypomastigotes, whereas the trypomastigote A-T content was 2.5-13% higher than the epimastigote A-T content. Although no obvious developmental stage association between total DNA and base composition was found, intrastage associations do exist. These observations were unaffected by nucleoprotein extraction implying that the observed differences between trypomastigotes and epimastigotes are not a consequence of nucleoprotein interference with DNA-binding fluorochromes. The nuclei and kinetoplasts of 4 T. cruzi stocks were isolated and analyzed. Developmental stage differences in nuclear and kinetoplast DNA are stock-dependent and base composition-dependent; both organelles contribute to the observed differences in DNA of intact cells. A nearly linear association between the percentage of total kinetoplast DNA, G-C, and A-T content was found. During metacyclogenesis, the G-C content decreases by approximately 7% as epimastigotes transform into metacyclic trypomastigotes. The decrease in G-C content precedes changes in morphology or in complement resistance. If the DNA changes are causally connected to developmental stage transformations in T. cruzi remains to be determined. However, the results could facilitate studies of the molecular genetic processes the parasite uses to successfully complete various phases of its life cycle and, consequently, the disease process it evokes. KW - developmental stages KW - differentiation KW - DNA KW - epimastigotes KW - Flow cytometry KW - Human diseases KW - parasites KW - trypomastigotes KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - deoxyribonucleic acid KW - growth phase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920874325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Is the recommended daily allowance for vitamin D too low for the homebound elderly? AU - Gloth, F. M., III AU - Tobin, J. D. AU - Sherman, S. S. AU - Hollis, B. W. JO - Journal of the American Geriatrics Society JF - Journal of the American Geriatrics Society Y1 - 1991/// VL - 39 IS - 2 SP - 137 EP - 141 SN - 0002-8614 AD - Gloth, F. M., III: Gerontology Research Center/Applied Physiology Section, National Institute on Aging/NIH, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19921446180. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition N2 - A population of sunlight-deprived elderly was studied to determine the daily intake of vitamin D and whether dietary intake was sufficient to maintain a normal vitamin D status. 22 subjects over 64 years old, with serum creatinine <180 µmol/litre and confined indoors for more than 6 months were chosen from the community and a nursing home in Southeast Baltimore, USA. Food records over a 3-day period were obtained along with serum levels of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2 D) and intact parathyroid hormone (PTH). The mean daily vitamin D intake was over 2-fold greater than the adult recommended daily allowance (RDA) of 200 IU. The mean 25-OHD level was 40 nmol/litre (normal 25-138 nmol/litre), with 7 patients less than 25 nmol/litre. Of those participants with 25-OHD values less than 25 nmol/litre, the mean vitamin D intake was 467 IU (range 36-1096 IU). It is concluded that the current RDA seems inadequate for many older individuals who do not get sun exposure. This particular population of elderly is at risk to develop vitamin D deficiency and the associated complications. KW - guidelines KW - Old age KW - requirements KW - vitamin D KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - recommendations KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446180&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning of the Plasmodium vivax Duffy receptor. AU - Fang, X. D. AU - Kaslow, D. C. AU - Adams, J. H. AU - Miller, L. H. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1991/// VL - 44 IS - 1 SP - 125 EP - 132 SN - 0166-6851 AD - Fang, X. D.: L.H. Miller, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872392. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - P. vivax and P. knowlesi merozoites invade only Duffy blood group-positive human erythrocytes. Soluble P. vivax and P. knowlesi merozoite proteins of MW 135 000 bind specifically to Duffy blood group determinants. The gene encoding a member of the Duffy receptor gene family of P. knowlesi was cloned. The molecular cloning of the presumptive Duffy receptor gene of P. vivax is reported, using the P. knowlesi gene as a probe. There is a single gene in P. vivax which codes for a protein of 1115 amino acids. The deduced amino acid sequence predicts a putative signal sequence at the amino-terminus and a transmembrane region followed by 45 amino acids at the carboxy-terminus. The 3 introns found at the 3′ end of the P. knowlesi gene were conserved in P. vivax, including high homology for the sequences of the introns. Comparison of the portion of the proteins amino to the transmembrane region between P. vivax and the partial sequence of P. knowlesi indicated at least 3 domains. Two homologous regions were separated by a non-homologous region. The cysteines in the homologous regions were conserved in number and position, indicating that the folding is similar and suggesting that these regions may be the Duffy blood group binding domains. In both P. vivax and P. knowlesi, the non-homologous region is hydrophilic and proline-rich, although the position of the prolines is not conserved. As prolines tend to stiffen a protein, this region may act as a 'hinge region' similar to those in the immunoglobulin gene family. KW - genes KW - Human diseases KW - molecular genetics KW - parasites KW - Apicomplexa KW - Plasmodium knowlesi KW - Plasmodium vivax KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - biochemical genetics KW - cloning KW - Duffy receptor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872392&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intra-generic conservation and limited inter-strain variation in a protective minor surface antigen of Plasmodium knowlesi merozoites. AU - Waters, A. P. AU - Thomas, A. W. AU - Mitchell, G. H. AU - McCutchan, T. F. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1991/// VL - 44 IS - 1 SP - 141 EP - 144 SN - 0166-6851 AD - Waters, A. P.: Malaria Section, Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872394. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The DNA fragment containing the PK66 gene from the Nuri strain of P. knowlesi was cloned from size-selected DraI-digested genomic DNA ligated into SmaI-digested, phosphatase-treated PUC 9 and screened with the entire cDNA insert isolated from a clone (A+) of the H strain of P. knowlesi. The DNA clone was sequenced on both strands throughout the coding region directly from the double-stranded plasmid using a series of primers specific for the gene. The gene encoding PK66 contained no repetitive elements and the sequence of the Nuri version was almost identical to that reported for the H strain. KW - antigens KW - genes KW - Human diseases KW - merozoites KW - molecular genetics KW - nucleotide sequences KW - parasites KW - surface antigens KW - Apicomplexa KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - 66-kDA KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - strain variations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of a species-specific repetitive DNA sequence from Loa loa. AU - Klion, A. D. AU - Raghavan, N. AU - Brindley, P. J. AU - Nutman, T. B. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1991/// VL - 45 IS - 2 SP - 297 EP - 305 SN - 0166-6851 AD - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872187. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - A genomic DNA library of L. loa was constructed in λgt11 using Eco-RI-digested DNA from microfilariae isolated from 2 West African patients. Screening with labelled L. loa DNA yielded several potential repetitive DNA clones. An MboI fragment of one of these, LL3M9, was identified and characterized. Sequence analysis of LL3M9 revealed an 839-bp fragment with an unusual 356-bp region containing 37 copies of the hexamer CTTAGG, many of which are arranged in repeated motifs of 12, 27 and 63 bp. This region shares many of the characteristics of eukaryotic satellite DNA. A synthetic oligonucleotide corresponding to the 27-bp repeated motif, LL3M9REP, was found to be both sensitive and species-specific by dot hybridization. Species specificity of LL3M9REP was confirmed by amplification of the repetitive region using genomic DNA as a template in the polymerase chain reaction.<new para>ADDITIONAL ABSTRACT:<new para>"A genomic DNA library of Loa loa was constructed in λgt11 using EcoRI-digested DNA from microfilariae isolated from 2 West African patients. Screening with labeled L. loa DNA yielded several potential repetitive DNA clones. An MboI fragment of 1 of these, LL3M9, was identified and characterized." KW - Filariids KW - helminths KW - Human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - repetitive DNA KW - Loa loa KW - Nematoda KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - African eyeworm KW - biochemical genetics KW - DNA genomic library KW - DNA sequences KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872187&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality among aerial pesticide applicators and flight instructors: a reprint. AU - Cantor, K. P. AU - Booze, C. F. JO - Archives of Environmental Health JF - Archives of Environmental Health Y1 - 1991/// VL - 46 IS - 2 SP - 110 EP - 116 SN - 0003-9896 AD - Cantor, K. P.: Environmental Epidemiology Branch, National Cancer Institute, 443 Executive Plaza North, Bethesda, MD 20892, USA. N1 - Accession Number: 19950500932. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health N2 - This is a reprint of an article which appeared previously in Archives of Environmental Health, 45: 295-302 (1990) to correct substantive errors introduced during production. KW - aerial spraying KW - agriculture KW - applicators KW - exposure KW - leukaemia KW - mortality KW - neoplasms KW - occupational hazards KW - occupations KW - pest control operators KW - pesticides KW - poisoning KW - spraymen KW - teratogens KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aerial and instructors KW - aerial applicators KW - blood cancer KW - cancers KW - death rate KW - leucaemia KW - leukemia KW - pesticide applicators KW - toxicosis KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pest and Weed Control Equipment (NN430) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950500932&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A recombinant clone of Wuchereria bancrofti with DNA specificity for human lymphatic filarial parasites. AU - Raghavan, N. AU - McReynolds, L. A. AU - Maina, C. V. AU - Feinstone, S. M. AU - Jayaraman, K. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1991/// VL - 47 IS - 1 SP - 63 EP - 71 SN - 0166-6851 AD - Raghavan, N.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases. Bldg. 4, Rm. 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873812. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Helminthology N2 - In order to understand the immune response to W. bancrofti and to aid in the diagnosis of W. bancrofti infections, recombinant antigens were identified from a W. bancrofti genomic expression library made in λgt11 using a pool of sera from infected Indian patients. One of the recombinant clones, λWbN1, containing a 2.5-kb insert, reacted strongly to a pool of sera from patients with lymphatic filariasis but not to normal human sera. In addition, this clone showed restricted specificity at the genomic level to the major lymphatic filarial parasites W. bancrofti and B. malayi but not to the closely related filarial parasite B. pahangi or to other filarial and non-filarial species tested. Nucleotide sequence analysis indicated the cloned DNA to have homology to myosin-like myofibrillar proteins. Polymerase chain reaction amplification initiated by specific synthetic oligomers amplified DNA in a species-specific manner from as little as 16 pg of isolated DNA or from one microfilaria. KW - antigens KW - DNA libraries KW - Filariids KW - helminths KW - molecular genetics KW - Nucleotide sequences KW - parasites KW - recombinant antigens KW - Nematoda KW - Wuchereria bancrofti KW - invertebrates KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stability of amphotericin B in 5% dextrose injection at 25°C. AU - Kintzel, P. E. AU - Kennedy, P. E. JO - American Journal of Hospital Pharmacy JF - American Journal of Hospital Pharmacy Y1 - 1991/// VL - 48 IS - 8 SP - 1681 EP - 1681 SN - 0002-9289 AD - Kintzel, P. E.: Pharmaceutical Development Service Analytical Laboratory, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19921212884. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - Amphotericin B at concn of 0.47, 0.66 and 0.75 mg/ml in 5% dextrose injection was determined to be chemically stable and physically compatible when stored at 25°C for up to 24 h. KW - Amphotericin B KW - Antifungal agents KW - stability KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212884&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hyperglycemic properties of serotonin receptor antagonists. AU - Wozniak, K. M. AU - Linnoila, M. JO - Life Sciences JF - Life Sciences Y1 - 1991/// VL - 49 IS - 2 SP - 101 EP - 109 SN - 0024-3205 AD - Wozniak, K. M.: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bldg.10 3C102, Bethesda, MD 20892, USA. N1 - Accession Number: 19911434842. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 50-67-9. Subject Subsets: Human Nutrition; Animal Nutrition N2 - Changes in the plasma glucose concentration of male NIH Swiss mice were measured after an injection of a non-selective (5-hydroxytryptamine, 5-HT) receptor antagonist (metergoline, 0.125-1.0 mg/kg body weight; methysergide, 2.5-10 mg/kg), a 5-HT2 and 5-HT10 antagonist (ritanserine, 0.62-2.4 mg/kg), or a 5-HT3 antagonist (3-tropanyl-3, 5-dichlorobenzoate, 5-10 mg/kg). The non-selective antagonists were hyperglycaemic at doses commonly used to antagonise 5-HT receptors. The 2 selective antagonists were only effective at a dose greater than that considered to be selective for their respective receptors. The results suggest that 5-HT systems play a role in maintaining glucose homeostasis and that 5-HT1 receptors may be particularly important in this function. The inherent hyperglycaemic properties of non-selective serotonin antagonists should be considered in studies using these agents to investigate glucose metabolism. KW - antagonists KW - blood KW - Serotonin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 5-HT KW - 5-hydroxytryptamine KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911434842&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Carboxy-terminal sequence conservation among variant-specific surface proteins of Giardia lamblia. AU - Mowatt, M. R. AU - Aggarwal, A. AU - Nash, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1991/// VL - 49 IS - 2 SP - 215 EP - 227 SN - 0166-6851 AD - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920876709. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Antigenic variation in G. lamblia [G. duodenalis] was studied by characterizing the expression and genomic organization of a variant-specific surface protein (VSP) gene. Transcripts from this gene, vsp1267, were abundant in the cloned variant WB/1267, but undetectable in the parental clone from which WB/1267 was derived or in variant progeny of WB/1267. Two identical copies of vsp1267 exist in the WB/1267 genome, separated by 3 kb and arranged as convergent transcription units. Primer extension sequencing and S1 nuclease protection analysis suggested that the 5′ untranslated region (UTR) of VSP1267 mRNA consists of a single nucleotide (nt). Primer extension sequencing mapped the site of VSP1267 transcript polyadenylation 25 nt beyond the termination codon. vsp1267 contained no introns and predicted a cysteine-rich polypeptide with features common to other VSPs. Comparison of vsp1267 with another VSP gene sequence revealed striking conservation, both at the nucleotide and amino acid levels, at the 3′ ends of the genes. An oligonucleotide derived from this region detected size-variant VSP transcripts in 4 of 5 G. lamblia clones analyzed, suggesting the general utility of this probe in studying VSP genes and their expression. KW - Antigenic variation KW - Human diseases KW - Molecular genetics KW - nucleotide sequences KW - parasites KW - Proteins KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - biochemical genetics KW - DNA sequences KW - Giardia lamblia KW - surface KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876709&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bovine somatotropin and the safety of cows' milk: National Institutes of Health technology assessment conference statement. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1991/// VL - 49 IS - 8 SP - 227 EP - 232 SN - 0029-6643 AD - Office of Medical Applications of Research, Building 1, Room 260, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910448191. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Registry Number: 9002-72-6. Subject Subsets: Dairy Science; Agricultural Biotechnology; Human Nutrition; Dairy Science N2 - The USA National Institutes of Health Consensus Conference was convened on 5-7 Dec. 1990 to evaluate available evidence on, and to resolve safety and efficacy questions related to the use of bovine somatotropin (GH) in the milk supply of the USA. The resultant statement was intended to advance understanding of the technology and issues, and to be useful to health professionals and the public. The statement was prepared by an expert panel on the basis of: 1. presentations by investigators working in areas relevant to the conference questions; 2. questions and statements from attendees at the open session of the conference; and 3. closed deliberations by the panel during the remainder of the second day and the morning of the third. The panel concluded that: 1. GH treatment increases milk yield of cows; 2. based on the data reviewed, GH administration does not appear to affect the general health of dairy cows appreciably; 3. the composition and nutritional value of milk from GH-treated cows is essentially the same as milk from untreated cows; 4. as currently used in the USA, meat and milk from GH-treated cows are as safe as those from untreated cows.<new para>ADDITIONAL ABSTRACT:<new para>This report by an expert panel reviews and evaluates available evidence on the safety and efficacy of the use of recombinant bovine somatotropin (rBST) in the United States' milk supply. The following topics were covered: the role of milk in human nutrition and methods for monitoring its safety for human consumption; comparative biology of human and bovine lactation and milk composition; the effect of administration of rBST on the milk production of cows and on the nutritional quality and hormonal content of their meat and milk; health effects on cows; health effects on man resulting from consumption of meat or milk from cows given rBST; and further animal and human research needed on use of rBST. It was concluded that rBST increased milk production of cows and did not appear to affect their general health appreciably. The composition and nutritive value of milk from treated cows was essentially the same as that from untreated cows, and as currently used in the USA, meat and milk from rBST-treated cows are as safe as those from untreated cows. KW - Biotechnology KW - Cows KW - foods KW - milk KW - nutritive value KW - public health KW - reviews KW - safety KW - Somatotropin KW - USA KW - cattle KW - man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - growth hormone KW - National Institutes of Health Consensus conference KW - nutritional value KW - quality for nutrition KW - United States of America KW - Milk and Dairy Produce (QQ010) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Health Services (UU350) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Food Science and Food Products (Human) (QQ000) KW - Food Composition and Quality (QQ500) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910448191&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cold tolerance and metabolic heat production in male C57BL/6J mice at different times of day. AU - Talan, M. I. AU - Tatelman, H. M. AU - Engel, B. T. JO - Physiology & Behavior JF - Physiology & Behavior Y1 - 1991/// VL - 50 IS - 3 SP - 613 EP - 616 SN - 0031-9384 AD - Talan, M. I.: Laboratory of Behavioral Sciences, National Institute of Aging, National Institutes of Health, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19921443324. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - Nine-month-old male C57BL/6J mice 9 months old were subjected to 3-h cold stress tests (partial restraint at 6°C) at 09.00 or 13.00 h. Tests were repeated 3 times at 2-week intervals at the same time of day. Body temperature was estimated by colonic thermoprobe and metabolic heat production by indirect calorimetry during each test. All mice showed habituation to repeated cold exposures (an improvement of cold tolerance across tests) due to an increase in metabolic heat production. The values of metabolic heat production were similar during morning and afternoon testing; however, mice tested in the afternoon had consistently poorer cold tolerance, which indicated increased heat loss. Increased heat loss in mice of similar body weight and presumably similar body composition, suggests that there is less effective cold-induced skin vasoconstriction during the afternoon. It was hypothesised that the compromised skin vasomotor response during the afternoon cold exposure results from competing effects of vasodilation due to local autoregulation stimulated by a circadian reduction of cardiac output during the sleep phase, and vasoconstriction due to the cold stress. KW - Cold tolerance KW - diurnal variation KW - Heat production KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorigenesis KW - thermogenesis KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443324&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vegetables, fruits, and carotenoids and the risk of cancer. AU - Ziegler, R. G. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 1 SP - 251S EP - 259S SN - 0002-9165 AD - Ziegler, R. G.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401707. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition N2 - The protective effect of fruits, vegetables and carotenoids against cancer is reviewed. Evidence suggests that low intake of vegetables, fruits and carotenoids is consistently associated with increased risk of lung cancer. In addition, low levels of β-carotene in serum or plasma are consistently associated with the subsequent development of lung cancer. It is also suggested that vegetable and fruit intake may reduce the risk of cancers of the mouth, pharynx, larynx, oesophagus, stomach, colon, rectum, bladder and cervix though evidence for these cancers is less persuasive than for lung cancer. KW - carcinoma KW - carotenoids KW - fruits KW - neoplasms KW - prevention KW - vegetables KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - tetraterpenoids KW - vegetable crops KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401707&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin C and cancer prevention: the epidemiologic evidence. AU - Block, G. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 1 SP - 270S EP - 282S SN - 0002-9165 AD - Block, G.: National Cancer Institute, EPN Room 313, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401710. Publication Type: Journal Article. Language: English. Number of References: 155 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Epidemiologic evidence of a protective effect of vitamin C for non-hormone-dependent cancers is discussed. Of 46 studies in which a dietary vitamin C index was calculated, 33 found significant protection compared with low intake. Of 29 additional studies that assessed fruit intake, 21 found significant protection. For cancers of the oesophagus, larynx, oral cavity and pancreas, evidence for a protective effect of vitamin C or some component in fruit was strong and consistent. For cancers of the stomach, rectum, breast and cervix there was also strong evidence. It is concluded that ascorbic acid, carotenoids and other factors in fruits and vegetables act jointly. KW - ascorbic acid KW - carcinoma KW - epidemiology KW - fruits KW - neoplasms KW - prevention KW - reviews KW - vegetables KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - vegetable crops KW - vitamin C KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Studies evaluating antioxidants and β-carotene as chemopreventives. AU - Malone, W. F. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 1 SP - 305S EP - 313S SN - 0002-9165 AD - Malone, W. F.: Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401715. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - The chemoprevention programme (National Cancer Institute, USA) is sponsoring 21 human efficacy studies. These trials are testing the potential of agents (β-carotene, folic acid, 13-cis retinoic acid, 4-hydroxyphenyl retinamide, vitamins C and E, and minerals) as inhibitors of a variety of cancers in man (colon, lung, oesophagus, cervix, bladder and skin). Study endpoints include overall incidence of cancer, incidence of specific cancers, rate of regression or progression of preneoplastic changes and changes in cellular or biochemical parameters. Study participants include volunteers from the general population; populations at high risk for cancer because of occupation, lifestyle or place of residence; persons with previously treated cancers; and persons with preneoplastic lesions. Study designs include single agent randomization, combination of agents and complete factorial designs. KW - antioxidants KW - beta-carotene KW - carcinoma KW - neoplasms KW - prevention KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401715&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary guidelines and the results of food consumption surveys. AU - Block, G. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 1 SP - 356S EP - 357S SN - 0002-9165 AD - Block, G.: National Cancer Institute, EPN Rm 313, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401723. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition N2 - The relation between dietary guidelines regarding fruits and vegetables and actual consumption in the USA is reviewed briefly. KW - consumption KW - diet KW - fruits KW - guidelines KW - reviews KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - recommendations KW - United States of America KW - vegetable crops KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401723&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antioxidants and aging. AU - Cutler, R. G. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 1 SP - 373S EP - 379S SN - 0002-9165 AD - Cutler, R. G.: Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19941401746. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 59-02-9, 9054-89-1, 69-93-2. Subject Subsets: Human Nutrition N2 - It is proposed that a common set of longevity determinant genes (LDG's) exist in all mammals independent of life span. It is suggested that antioxidants including superoxide dismutase, carotenoids, α-tocopherol and uric acid represent LDG's and may play a role in determining frequency of age-dependent diseases and duration of general health. KW - aging KW - alpha-tocopherol KW - antioxidants KW - carotenoids KW - superoxide dismutase KW - uric acid KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - tetraterpenoids KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401746&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aging and energy expenditure. AU - Vaughan, L. AU - Zurlo, F. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 4 SP - 821 EP - 825 SN - 0002-9165 AD - Vaughan, L.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19921440129. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - Whether sedentary energy expenditure is normal or lower in elderly people has not yet been clearly established. Energy expenditure for 24 h (24EE) and its different components were estimated by use of a respiratory chamber in elderly (17 male, 21 female; 71±6 years old, (mean±s.d.); 71.2±13.5 kg; 32±8% fat) and young (33 male, 31 female; 24±4 years old; 84.5±23.1 kg; 25±13% fat) subjects. The elderly subjects had lower mean height (P<0.001), weight (P<0.01) and fat-free mass (P<0.001) but higher percentage body fat (P<0.01) than did the young adults. Absolute 24EE, basal metabolic rate (BMR) and sleeping metabolic rate were lower (P<0.01) in elderly than in young subjects. After differences in fat-free mass, fat mass and sex were adjusted for, only BMR was lower in the elderly subjects (P<0.01). Despite a reduced adjusted BMR in older subjects, sedentary 24EE was decreased only in proportion to their reduced body size, suggesting that the lower energy intake reported in elderly people might be mainly related to lower physical activity in free-living conditions. KW - energy exchange KW - Old age KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440129&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy cost of physical activity on a metabolic ward in relationship to obesity. AU - Ferraro, R. AU - Boyce, V. L. AU - Swinburn, B. AU - Gregorio, M. de AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - 6 SP - 1368 EP - 1371 SN - 0002-9165 AD - Ferraro, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19921442621. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - The energy cost of physical activity on a metabolic ward was derived from the difference between the energy requirement to maintain body weight on a metabolic ward and sedentary 24-h energy expenditure measured in a respiratory chamber in 56 non-diabetic men. The cost of physical activity was negatively correlated with body weight (r = -0.67, P<0.0001) and with percent body fat (r = -0.48, P<0.0005). In a subgroup of 15 men selected for strict weight stability (rate of weight change less than ±35 g daily), similar negative correlations were observed between energy cost of activity and body weight (r = -0.61, P<0.01) and percent body fat (r = -0.51, P = 0.05). The ratio of active to sedentary energy expenditure, an index of physical activity, was also negatively correlated with body weight and percent body fat (r = -0.74, P<0.002 and r = -0.61, P<0.02, respectively). The results suggest that heavier subjects on a metabolic ward are less active and expend less energy in physical activity than do lighter subjects. KW - energy cost of activities KW - Obesity KW - physical activity KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442621&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Obesity in the Pima Indians: its magnitude and relationship with diabetes. AU - Knowler, W. C. AU - Pettitt, D. J. AU - Saad, M. F. AU - Charles, M. A. AU - Nelson, R. G. AU - Howard, B. V. AU - Bogardus, C. AU - Bennett, P. H. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 53 IS - Suppl. 6 SP - 1543 EP - 1551 SN - 0002-9165 AD - Knowler, W. C.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA. N1 - Accession Number: 19921442742. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - Members of the Pima Indian population are obese, on average, as estimated by the body mass index (BMI). Young adults have had the highest BMIs and there have been modest increases in age- and sex-specific mean BMIs for the past 25 years. These observations suggest that the older adults have had less exposure to factors leading to obesity than have the younger adults. Compared with children studied early in this century, present-day Pima children are much heavier for height, suggesting that the degree of obesity has increased since that time. Obesity in the Pimas is familial and has complex relationships with non-insulin-dependent diabetes mellitus, a common disease in this population. Obesity predicts the development of diabetes; once people have diabetes, however, they tend to lose weight. Thus, obesity should not be studied in this population without also considering diabetes, which tends to limit the degree of obesity. KW - diabetes KW - Ethnic groups KW - incidence KW - obesity KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum. AU - Dhariwal, K. R. AU - Hartzell, W. O. AU - Levine, M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - 4 SP - 712 EP - 716 SN - 0002-9165 AD - Dhariwal, K. R.: M. Levine, Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921442820. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 50-81-7, 490-83-5. Subject Subsets: Human Nutrition N2 - To investigate whether circulating ascorbic acid in man is protein-bound or free and whether ascorbic acid exists in its reduced form alone as ascorbic acid or in its reduced and oxidized forms (ascorbic acid and dehydroascorbic acid, respectively) ascorbic acid and dehydroascorbic acid were determined by using HPLC with coulometric electrochemical detection, and protein binding was determined by centrifugal ultrafiltration. Ascorbic acid was free in plasma and serum of normal, healthy volunteers, (10 men, 10 women). Ascorbic acid was detectable only in its reduced form. However, dehydroascorbic acid could be made to appear in samples processed under oxidizing conditions. Because circulating ascorbic acid is free and is detected only in its reduced form, ascorbic acid may be available without intermediates for peripheral utilization. Dehydroascorbic acid may not be present in plasma and serum of normal humans unless assay conditions permit ascorbic acid oxidation. KW - Ascorbic acid KW - blood KW - Dehydroascorbic acid KW - estimation KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442820&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid and oxidative inactivation of proteins. AU - Stadtman, E. R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - Suppl. 6 SP - 1125S EP - 1128S SN - 0002-9165 AD - Stadtman, E. R.: National Institutes of Health, 9000 Rockville Pike, Building 3, Room 222, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446360. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 56 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - A number of active oxygen species are probably implicated in the aetiology or manifestation of several pathological conditions, including aging, arthritis, carcinogenesis, atherosclerosis and muscular dystrophy. Ascorbate plays a key role in protecting cells against oxidative damage. Paradoxically, in the presence of Fe3+ or Cu2+, ascorbate can promote the generation of the same reactive oxygen species (OH, O-2, H2O2, and ferryl ion) it is known to destroy. This prooxidant activity derives from the ability of ascorbate to reduce Fe3+ or Cu2+ to Fe2+ or Cu+, respectively, and to reduce O2 to O2- and H2O2. Damage to nucleic acid and proteins results from the binding of either Fe2+ or Cu+ to metal binding sites on these macromolecules followed by reaction of the metal complexes with H2O2; this leads to the production of active oxygen species that attack functional groups at or near the metal binding sites. KW - ascorbic acid KW - oxidation KW - Proteins KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascorbic acid, biologic functions and relation to cancer KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446360&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. AU - Peterkofsky, B. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - Suppl. 6 SP - 1135S EP - 1140S SN - 0002-9165 AD - Peterkofsky, B.: Building 37 Room 4C-18, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446362. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 54 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Ascorbic acid deficiency is associated with defective connective tissue, particularly in wound healing. Ascorbate is required for hydroxylation of proline residues in procollagen and hydroxyproline stabilizes the collagen triple helical structure. Consequently, ascorbate stimulates procollagen secretion. However, collagen in synthesis in ascorbate-deficient guineapigs is decreased with only moderate effects on proline hydroxylation. Proteoglycan synthesis, which does not require ascorbate, also is decreased and both effects are correlated with the extent of weight loss during scurvy. Fasting, with ascorbate supplementation, produces similar effects. Both functions are inhibited in cells cultured in sera from scorbutic or starved guineapigs and inhibition is reversed with insulin-like growth factor (IGF)-I. The inhibitor seems to consist of 2 IGF-binding proteins induced during ascorbic acid deficiency and starving and may be responsible for inhibition of collagen and proteoglycan synthesis in vivo. KW - ascorbic acid KW - collagen KW - Scurvy KW - synthesis KW - USA KW - guineapigs KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascorbic acid, biologic functions and relation to cancer KW - guinea pigs KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid and in situ kinetics: a new approach to vitamin requirements. AU - Levine, M. AU - Dhariwal, K. R. AU - Washko, P. W. AU - Butler, J. D. AU - Welch, R. W. AU - Wang, Y. AU - Bergsten, P. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - Suppl. 6 SP - 1157S EP - 1162S SN - 0002-9165 AD - Levine, M.: Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446367. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 42 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Ascorbic acid requirements are based on preventing the deficiency disease scurvy and on urinary excretion of vitamin C. The first quantitative approach to determining optimal requirements for ascorbic acid and other vitamins, called kinetics in situ is proposed. Kinetics in situ biochemically is based on the application of Michaelis-Menten reaction kinetics to ascorbic acid-dependent reactions in situ. Clinically kinetics in situ is based on estimating vitamin availability to tissues so that cell-specific reactions can occur. The biochemical concepts of kinetics in situ are verified for the first time through studying ascorbic acid regulation of norepinephrine biosynthesis. The principles of kinetics in situ can now be applied to man and human cells and for determining optimal requirements for ascorbic acid and for other vitamins. KW - Ascorbic acid KW - estimation KW - requirements KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascorbic acid, biologic functions and relation to cancer KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446367&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid and the eye. AU - Garland, D. L. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - Suppl. 6 SP - 1198S EP - 1202S SN - 0002-9165 AD - Garland, D. L.: National Institutes of Health, Building 6, Room 235, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446374. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 78 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Literature on transport and function of ascorbic acid in ocular tissues is reviewed. The role of ascorbic acid in various regions of the eye is not well understood. It appears one important function of this compound is protection against oxidative damage, particularly photoinduced damage. In contrast, data are also reviewed that suggest ascorbic acid may participate in the oxidative modification of lens proteins seen with aging. KW - ascorbic acid KW - Eyes KW - reviews KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascorbic acid, biologic functions and relation to cancer KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid in human neutrophils. AU - Washko, P. AU - Rotrosen, D. AU - Levine, M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1991/// VL - 54 IS - Suppl. 6 SP - 1221S EP - 1227S SN - 0002-9165 AD - Washko, P.: M. Levine, Building 8, Room 415, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446378. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 45 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - The uptake and distribution of ascorbic acid and the effect of extracellular glucose on ascorbic acid transport were investigated in human neutrophils. Freshly isolated neutrophils contained ascorbic acid 1.0 to 1.4 mmol/litre, at least 94% of which was present unbound in the cytosol. Intracellular ascorbic acid was found only in the reduced form. The presence of physiologic amounts of ascorbic acid in the extracellular buffer led to the accumulation of millimolar concentrations of ascorbic acid intracellularly. Accumulation was mediated by a high- and a low-affinity transport activity. The high-affinity transport activity had an apparent Km of 2 to 5 µmol/litre whereas the low-affinity transport activity had an apparent Km of 6 to 7 mmol/litre. Glucose inhibited uptake and accumulation of ascorbic acid by both transport activities in a concentration-dependent fashion. Glucose-induced inhibition of both ascorbic acid transport activities was completely reversible. KW - Ascorbic acid KW - neutrophils KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascorbic acid, biologic functions and relation to cancer KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446378&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolate and epitope variability in susceptibility of Giardia lamblia to intestinal proteases. AU - Nash, T. E. AU - Merritt, J. W. AU - Conrad, J. T. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1991/// VL - 59 IS - 4 SP - 1334 EP - 1340 SN - 0019-9567 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808679. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - The surface antigens of Giardia lamblia [G. duodenalis] differ. To determine whether the unique surface antigens found in variants and isolates could differentially protect the parasite from digestion by intestinal proteases, G. lamblia clones WB-2X (WB), GS/M-H7 (GS/M), and B6, each of which expresses a unique surface variant antigen, were exposed to α-chymotrypsin and trypsin at concentrations up to 20 mg/ml in culture medium. The number of surviving trophozoites and morphologic changes were assessed over time. After 24 h, there was a significant decrease in the number of surviving trophozoites of WB (80.5 and 94.2% for trypsin and α-chymotrypsin treatments, respectively, compared with controls) and B6 (78.6 and 95.5% for trypsin and α-chymotrypsin treatments, respectively compared with controls) at 10 mg of enzyme per ml compared with culture medium alone. Cytotoxicity was prevented by the presence of soybean trypsin inhibitor, indicating the effects were due to protease activity. In contrast, there was no significant cytotoxicity after exposure of GS/M to either enzyme at the same enzyme concentration. After exposure to α-chymotrypsin, susceptible G. lamblia became rounded and then lysed, but after exposure to trypsin, G. lamblia appeared plastered onto the surface of the well and was intertwined and surrounded by finely granular material. Effects were concentration and time dependent; at least 6 h of treatment was required to observe changes 12 to 18 h later. Trophozoites surviving α-chymotrypsin or trypsin exposure became stably resistant to protease treatment. In vitro, the variant surface antigen of GS/M, but not those of WB or B6, resisted digestion by trypsin or α-chymotrypsin, suggesting that the variant surface antigens impart susceptibility or resistance to digestion. The initial surface variant antigens of WB and B6 were replaced in resistant cultures. Trophozoites differ in their ability to survive after exposure to intestinal proteases, which may enable certain G. lamblia isolates or isolates possessing certain surface variant antigens to survive in the small intestine. KW - antigenic variation KW - Antigens KW - Enzymes KW - Epitopes KW - Human diseases KW - Immune evasion KW - parasites KW - surface antigens KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic determinants KW - antigenic polymorphism KW - antigenicity KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808679&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chromosomal rearrangement in Candida stellatoidea results in a positive effect on phenotype. AU - Wickes, B. L. AU - Golin, J. E. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1991/// VL - 59 IS - 5 SP - 1762 EP - 1771 SN - 0019-9567 AD - Wickes, B. L.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911209094. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Medical & Veterinary Mycology N2 - When type I C. stellatoidea is plated onto sucrose agar at levels in excess of 108 cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements were studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement. KW - chromosomes KW - genetics KW - phenotypes KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida stellatoidea KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209094&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cryptococcus neoformans serotype A glucuronoxylomannan-protein conjugate vaccines: synthesis, characterization, and immunogenicity. AU - Devi, S. J. N. AU - Schneerson, R. AU - Egan, W. AU - Ulrich, T. J. AU - Bryla, D. AU - Robbins, J. B. AU - Bennett, J. E. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1991/// VL - 59 IS - 10 SP - 3700 EP - 3707 SN - 0019-9567 AD - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210274. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health; Tropical Diseases N2 - C. neoformans serotype A glucuronoxylomannan (GXM) conjugate vaccines were synthesized under conditions suitable for human use to prevent disseminated cryptococcosis. The purified, sonicated GXM was derivatized with adipic acid dihydrazide through either hydroxyl or carboxyl groups and then covalently bound to tetanus toxoid (TT) or Pseudomonas aeruginosa exoprotein A (rEPA). The immunogenicity of these conjugates was evaluated in BALB/c and general purpose mice by subcutaneous injection in saline. The conjugates elicited higher GXM antibody responses than GXM alone. Booster immunoglobulin G (IgG) and IgM responses were elicited by all conjugates in BALB/c mice. The conjugates prepared through hydroxyl activation (GXM-TT2 and GXM-rEPA) were more immunogenic than the one prepared through carboxyl activation (GXM-TT1). GXM antibody response was enhanced by the administration of monophosphoryl lipid A 2 d following the injection of GXM-TT2 (P<0.03). The conjugates also elicited IgG antibodies to the carrier proteins. Gel diffusion tests using conjugate-induced hyperimmune sera and chemically modified GXMs suggested that the specificity of GXM-TT1-induced antibodies was conferred by the O-acetyl groups. Hyperimmune sera generated by GXM-TT2 precipitated with the chemically unmodified and the de-O-acetylated GXMs but not with the carboxyl-reduced and de-O-acetylated GXM. GXM-TT2-induced hyperimmune serum also precipitated with the capsular polysaccharides of C. neoformans serotypes D, B and C. It is concluded that the conjugate vaccines prepared through hydroxyl activation of the GXM are sufficiently immunogenic and appear to be suitable for clinical evaluation.<new para>ADDITIONAL ABSTRACT:<new para>The authors conclude from studies in BALB/c and other mice that the conjugate vaccines prepared through hydroxyl activation of the Cryptococcus neoformans serotype A glucuronoxylomannan are "sufficiently immunogenic and appear to be suitable for clinical evaluation".Carolyn A. Brown KW - immunology KW - vaccines KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - glucuronoxylomannan-protein KW - serotype A KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210274&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selection of genetic variants from Plasmodium clones. AU - Dolan, S. A. AU - Miller, L. H. AU - Wellems, T. E. JO - Acta Leidensia JF - Acta Leidensia Y1 - 1991/// VL - 60 IS - 1 SP - 93 EP - 99 SN - 0065-1362 AD - Dolan, S. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803131. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology N2 - Clones of Plasmodium alter their antigenic profile or invasion phenotype when presented with specific challenges. Two examples, using Plasmodium knowlesi and P. falciparum, are reviewed which may represent different genetic mechanisms of adaptation to selection pressures. In these 2 examples, immune pressure and changes in the carbohydrate structure of the erythrocyte were used to challenge parasite clones. In both cases, the parasite adapted readily to produce variants that were no longer affected by the selection pressure. It is suggested that vaccine trials should include studies on the selection of mutations in the target antigen. KW - clones KW - genetic variation KW - malaria KW - parasites KW - North America KW - USA KW - Plasmodium falciparum KW - Plasmodium knowlesi KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - genetic variability KW - genotypic variability KW - genotypic variation KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803131&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. AU - Falgout, B. AU - Pethel, M. AU - Zhang, Y. M. AU - Lai, C. J. JO - Journal of Virology JF - Journal of Virology Y1 - 1991/// VL - 65 IS - 5 SP - 2467 EP - 2475 SN - 0022-538X AD - Falgout, B.: C.J. Lai, Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19920511806. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The cleavages at the junctions of the flavivirus nonstructural (NS) proteins NS2A/NS2B, NS2B/NS3, NS3/NS4A and NS4B/NS5 share an amino acid sequence motif and are presumably catalysed by a virus-encoded protease. Recombinant vaccinia viruses expressing various portions of the NS region of the dengue virus type 4 polyprotein were constructed. By analysing the immune precipitates of 35S-labelled lysates of recombinant virus-infected cells, the NS2A/NS2B, NS2B/NS3 and NS3/NS4A cleavages were monitored. A polyprotein composed of NS2A, NS2B and the N-terminal 184 amino acids of BS3 was cleaved at the NS2A/NS2B and NS2B/NS3 junctions, whereas a similar polyprotein containing only the first 77 amino acids of NS3 was not. This finding is consistent with the proposal that the N-terminal 180 amino acids of NS3 constitute a protease domain. Polyproteins containing NS2A and NS3 with large in-frame deletions of NS2B were not cleaved at the NS2A/NS2B or NS2B/NS3 junctions. Coinfection with a recombinant expressing NS2B complemented these NS2B deletions for NS2B/NS3 cleavage and probably also for NS2A/NS2B cleavage. Thus, NS2B is also required for the NS2A/NS2B and NS2B/NS3 cleavages and can act in trans. Other experiments showed that NS2B was needed, apparently in cis, for NS3/NS4A cleavage and for a series of internal cleavages in NS3. Indirect evidence that NS3 can also act in trans was obtained. Models are discussed for 2-component protease activity requiring both NS2B and NS3. KW - Arboviruses KW - Proteinases KW - proteolysis KW - viral proteins KW - Dengue virus KW - Flaviviridae KW - Flavivirus KW - Vaccinia virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - arthropod-borne viruses KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511806&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of CD4+ and CD8+ T cells in murine resistance to street rabies virus. AU - Perry, L. L. AU - Lodmell, D. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1991/// VL - 65 IS - 7 SP - 3429 EP - 3434 SN - 0022-538X AD - Perry, L. L.: D.L. Lodmell, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19912254371. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - Mice of the SJL/J and BALB/cByJ inbred strains are naturally resistant to street rabies virus (SRV) injected via the i.p. route. To determine the cellular mechanism of resistance, monoclonal antibodies specific for CD4+ or CD8+ T cells were used to deplete the respective cell population in SRV-infected animals. Elimination of CD4+ T-helper cells abrogated the production of immunoglobulin G (IgG) neutralizing antibodies in response to rabies virus infection and reversed the resistant status of SJL/J and BALB/cByJ mice. In contrast, in vivo depletion of CD8+ cytotoxic T cells had no effect on the host resistance to SRV. These results indicate that serum neutralizing antibodies of the IgG class are a primary immunological mechanism of defence against rabies virus infection in this murine model. CD8+ cytoxic T lymphocytes, which have been shown to transfer protection in other rabies virus systems, appear to have no role in protecting mice against i.p. injected SRV. KW - disease resistance KW - Experimental infection KW - Rabies KW - T lymphocytes KW - viral diseases KW - Virus neutralization KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease resistence KW - experimental transmission KW - Monclonal antibodies KW - resistance to disease KW - T cells KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912254371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The comparative fine structure and surface glycoconjugate expression of three life stages of Leishmania major. AU - Pimenta, P. F. P. AU - Saraiva, E. M. B. AU - Sacks, D. L. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1991/// VL - 72 IS - 2 SP - 191 EP - 204 SN - 0014-4894 AD - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910871069. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The cellular ultrastructure and surface glycoconjugate expression of 3 life-cycle stages of L. major (MHOM/IL/80/FRIEDLIN) were compared. Noninfective logarithmic phase promastigotes (LP) are immature cell bearing a thin cell coat, short flagellum, small and empty flagellar pocket, and a loose cytoplasm filled with profiles of ER and large Golgi complex. LP also contain subpopulations of maturing cells containing less ER and Golgi and synthesizing cytoplasmic granules of different size, number, and electrondensity. Infective or metacyclic promastigotes (MP) are fully differentiated nondividing forms with a thickened, prominent cell coat, long flagellum, distended flagellar pocket filled with secretory material, and few cytoplasmic organelles other than abundant electron-dense granules. Tissue amastigotes also contain electron-dense cytoplasmic granules, their flagellar pockets are also enlarged and contain secretory material, but they lack a discernable cell coat. Immunogold labelling of GP63 on the cell surface was extensive only on amastigotes. Promastigote GP63 appeared to be masked by the presence of a densely packed lipophosphoglycan (LPG) coat which was extensively labelled on the entire surface of MP and LP. An elongated, developmentally modified form of LPG was abundantly labelled only on MP. LPG was poorly labelled on amastigotes, arguing that the promastigote cell coat is a stage-specific structure which is lost during intracellular transformation. KW - amastigotes KW - Biochemistry KW - comparisons KW - Developmental stages KW - enzymes KW - Human diseases KW - parasites KW - promastigotes KW - proteinases KW - ultrastructure KW - Leishmania major KW - protozoa KW - Sarcomastigophora KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - growth phase KW - proteases KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910871069&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and caucasians. AU - Lillioja, S. AU - Nyomba, B. L. AU - Saad, M. F. AU - Ferraro, R. AU - Castillo, C. AU - Bennett, P. H. AU - Bogardus, C. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1991/// VL - 73 IS - 4 SP - 866 EP - 876 SN - 0021-972X AD - Lillioja, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix Indian Medical Center/National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19921442614. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Pima Indians (Arizona, USA) have the highest reported prevalence rate of non-insulin-dependent diabetes mellitus (NIDDM) in the world. 81 white adults were compared with 211 Pima Indian non-diabetic subjects similar in age, sex, degree of obesity and glucose tolerance. During a hyperinsulinaemic euglycaemic clamp at physiological insulin concentrations, Pima Indians were 17% more insulin resistant than whites after accounting for any differences in degree of obesity (P<0.0001). During oral glucose tolerance testing, mean plasma insulin concentrations were 33% higher in the Pimas (P<0.0001), but these differences were largely explained by the greater insulin resistance in the Pimas. Insulin clearance did not differ between the races. However, early insulin responses were exaggerated in the Indians and not explained by insulin resistance. After accounting for differences in insulin action, plasma insulin concentrations in Pima Indians were 50% higher than those in whites 3 to 5 min after intravenous glucose (P<0.0001), 38% higher 10 min after the end of a meal (P<0.0001) and 20% higher 30 min after an oral glucose load (P<0.006). Data suggest that in addition to insulin resistance, Pima Indians have exaggerated early insulin release and increased β-cell mass or enhanced β-cell sensitivity to glucose. The data argue against low or delayed insulin secretion as primary factors leading to NIDDM in Pima Indians and favour insulin resistance as the underlying and initiating cause of the disease. KW - diabetes KW - Ethnic groups KW - insulin KW - resistance KW - risk KW - Arizona KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mountain States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southwestern States of USA KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442614&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Demographic and behavioral predictors of Trichomonas vaginalis infection among pregnant women. AU - Cotch, M. F. AU - Pastorek, J. G., II AU - Nugent, R. P. AU - Yerg, D. E. AU - Martin, D. H. AU - Eschenbach, D. A. JO - Obstetrics and Gynecology (New York) JF - Obstetrics and Gynecology (New York) Y1 - 1991/// VL - 78 IS - 6 SP - 1087 EP - 1092 SN - 0029-7844 AD - Cotch, M. F.: NIAID Division of Microbiology and Infectious Diseases, National Institutes of Health, Control Data Building, Room 3A24, Bethesda, MD 20892, USA. N1 - Accession Number: 19920881091. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology N2 - A study was made of the demographic and behavioral predictors of infection with Trichomonas vaginalis among pregnant women in the USA. Among 13 816 women from 6 urban clinic centres (in New York, Seattle, Oklahoma City, San Antonio, New Orleans), the prevalence rate by culture at mid-pregnancy was 12.6%. Women colonized with T. vaginalis were significantly more likely to be black, cigarette smokers, unmarried, and less educated. Several behavioural factors associated with T. vaginalis infection included greater numbers of sexual partners throughout life, and in the last year, and a history of gonorrhoea. Women using barrier or oral contraception in the 6 months before becoming pregnant were far less likely to become colonized with T. vaginalis. KW - epidemiology KW - females KW - human diseases KW - parasites KW - pregnancy KW - Louisiana KW - New York KW - North America KW - Oklahoma KW - Texas KW - USA KW - Washington KW - man KW - protozoa KW - sarcomastigophora KW - trichomonadidae KW - Trichomonas vaginalis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Protozoa KW - Trichomonadida KW - Sarcomastigophora KW - Trichomonas KW - Trichomonadidae KW - Delta States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Gulf States of USA KW - West South Central States of USA KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - Great Plains States of USA KW - Southern Plains States of USA KW - Southwestern States of USA KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - gestation KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intake of tapwater and total water by pregnant and lactating women. AU - Ershow, A. G. AU - Brown, L. M. AU - Cantor, K. P. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1991/// VL - 81 IS - 3 SP - 328 EP - 334 SN - 0090-0036 AD - Ershow, A. G.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19910447494. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7732-18-5. Subject Subsets: Dairy Science; Human Nutrition N2 - Despite theoretically higher requirements for water due to the physiological demands of pregnancy and lactation, little is known of the actual ranges of intake in pregnant and lactating women. Population-based estimates of total water and tap-water intake in women of reproductive age were derived using data from the 1977-78 USDA Nationwide Food Consumption Survey. Three-day av. intakes were calculated for 188 pregnant women, 77 lactating women and 6201 non-pregnant, non-lactating control women. Total water intake (mean±s.d.) was 1940±686 g/day (median 1835) for control women, 2076±743 g/day (median 1928) for pregnant women and 2242±658 g/day (median 2164) for lactating women. Tap-water intake was 1157±635 g/day (median 1065) for control women, 1189±699 g/day (median 1063) for pregnant women and 1310±591 g/day (median 1330) for lactating women. Total water intake was ≥3000 g/day among 7% of control women, 11% of pregnant women and 13% of lactating women. Tap-water intake was ≥2000 g/day among 10% of control women, 15% of pregnant women and 8% of lactating women. These results should be useful in estimating amounts of nutrients and toxic substances that women of reproductive age obtain through the water supply. KW - intake KW - lactation KW - pregnancy KW - tap water KW - Water KW - water intake KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gestation KW - human lactation KW - Human Nutrition (General) (VV100) KW - Milk and Dairy Produce (QQ010) KW - Diet Studies (VV110) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910447494&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of soy products in reducing risk of cancer. AU - Messina, M. AU - Barnes, S. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1991/// VL - 83 IS - 8 SP - 541 EP - 546 SN - 0027-8874 AD - Messina, M.: Diet and Cancer Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921442185. Publication Type: Journal Article. Language: English. Number of References: 83 ref. Subject Subsets: Human Nutrition; Soyabeans N2 - This commentary is based on the findings of a recent workshop on the role of soya products in cancer prevention. Its objectives were to evaluate the relationship between the risk of certain cancers and consumption of soyabeans, soyabean products and specific components of soyabeans, and to recommend research initiatives aimed at clarifying this relationship. It was concluded that there were sufficient data to justify studying the impact of soyabean intake on cancer risk in humans and to carry out basic research on the absorption, metabolism and physiology of potential anticarcinogens for humans in soyabean components. KW - Carcinoma KW - prevention KW - reviews KW - soyabean products KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - soybean products KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442185&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid: biologic functions and relation to cancer. AU - Henson, D. E. AU - Block, G. AU - Levine, M. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1991/// VL - 83 IS - 8 SP - 547 EP - 550 SN - 0027-8874 AD - Henson, D. E.: Early Detection Branch, Division of Cancer Prevention and Control, Executive Plaza North, Rm 305, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921442186. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - This report is based on the findings of a symposium held at the National Institutes of Health, September 10-12, 1990, when the antioxidant, enzymic, immune and cancer-related functions of ascorbic acid were discussed. It was concluded that vitamin C has multiple complex effects on a variety of biological activities. Some effects were the result of interaction of vitamin C and enzymes, whereas others are independent of enzymic function, apparently related to its chemical properties and not to its role as a vitamin. A unifying principle to explain the seemingly unrelated effects of vitamin C is needed. Any role for ascorbate in prevention and treatment of cancer will be established only through increased knowledge of its biological actions. KW - ascorbic acid KW - Carcinoma KW - metabolism KW - prevention KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442186&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Case-control study of canine malignant lymphoma: positive association with dog owner's use of 2,4-dichlorophenoxyacetic acid herbicides. AU - Hayes, H. M. AU - Tarone, R. E. AU - Cantor, K. P. AU - Jessen, C. R. AU - McCurnin, D. M. AU - Richardson, R. C. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1991/// VL - 83 IS - 17 SP - 1226 EP - 1231 SN - 0027-8874 AD - Hayes, H. M.: Environmental Epidemiology Branch, National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19922267230. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4. Subject Subsets: Veterinary Science; Horticultural Science; Veterinary Science; Weeds N2 - A hospital-based case-control study of pet dogs examined the risk of developing canine malignant lymphoma associated with the use of chemicals in and about the home. Information from a self-administered owner questionnaire and/or a telephone interview of about 491 cases, 466 nontumour controls, and 479 tumour controls indicated that owners in households with dogs that developed malignant lymphoma applied 2,4-dichlorophenoxyacetic acid (2,4-D) herbicides to their lawn and/or employed commercial lawn care companies to treat their yard more frequently than control owners (odds ratio = 1.3). In addition, the risk of canine malignant lymphoma rose to a 2-fold excess with 4 or more yearly owner applications of 2,4-D. These findings are consistent with occupational studies in man, which have reported modest associations between agricultural exposure to 2,4-D and increased risk of non-Hodgkin's lymphoma, the histology and epidemiology of which are similar to those of canine malignant lymphoma. The present study suggests that human health implications of 2,4-D exposure in the home environment should receive further investigation. KW - 2,4-D KW - application KW - Carcinogens KW - control KW - Herbicides KW - lawns and turf KW - lymphoma KW - neoplasms KW - ornamental plants KW - Pets KW - safety KW - toxicology KW - weeds KW - USA KW - dogs KW - man KW - plants KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - (2,4-dichlorophenoxy)acetic acid KW - cancers KW - lawns and sports turf KW - ornamentals KW - pet animals KW - United States of America KW - weedicides KW - weedkillers KW - Pets and Companion Animals (LL070) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Weeds and Noxious Plants (FF500) KW - Occupational Health and Safety (VV900) KW - Non-Communicable Diseases and Injuries of Animals (LL860) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922267230&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hypochloremic metabolic alkalosis from ingestion of a chloride-deficient infant formula: outcome 9 and 10 years later. AU - Malloy, M. H. AU - Graubard, B. AU - Moss, H. AU - McCarthy, M. AU - Gwyn, S. AU - Vietze, P. AU - Willoughby, A. AU - Rhoads, G. G. AU - Berendes, H. JO - Pediatrics JF - Pediatrics Y1 - 1991/// VL - 87 IS - 6 SP - 811 EP - 822 SN - 0031-4005 AD - Malloy, M. H.: Epidemiology Branch/PRP, National Institute of Child Health and Human Development, Executive Plaza North, Room 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19911438594. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 16887-00-6. Subject Subsets: Human Nutrition; Soyabeans N2 - In 1978 and 1979 two infant formulae produced in the USA, Neo-Mull-Soy and Cho-Free, were found to be deficient in chloride. The Centers for Disease Control received reports that hypochloraemic metabolic alkalosis (HMA) had developed in 141 children as a result of exposure to these formulae. Of these children 35 were examined at 9 and 10 years old and compared with a group of 32 children who were exposed to the chloride-deficient formulae but were not reported to experience HMA and a group of 61 children who received chloride-sufficient soya formulae in infancy. The control children were matched to the HMA children on sex, race, age and maternal education. Growth characteristics, performance on the Wechsler Intelligence Scale for Children-Revised (WISC-R), the Boston Naming Test, the Rey-Osterrieth Test, the Clinical Evaluation of Language Fundamentals Revised (CELF-R), and subtests from several other speech and language tests were compared across the groups. After adjustment for family income and the level of the father's education, significantly lower scores were observed in the HMA children on the WISC-R Arithmetic subtest (mean = 10.5) compared with the soya control children (mean = 12.0, P<0.05)and on the WISC-R Coding subtest (mean = 9.0) compared with the soya control children (mean = 10.8, P<0.01). All the WISC-R subtest scores were within the normal range. Although no significant differences occurred on the CELF-R between groups, the risk of an HMA child falling below the range expected for a standard population was increased on the CELF-R Composite Total, Receptive and Expressive Language scores: risk ratios = 2.14, 2.14, and 3.03 respectively. Significant differences were observed between the children exposed, both HMA and non-HMA children, and the soya control children for behavioural problems as determined by the Achenbach Childhood Behavioral Checklist. It is concluded that as a group, children with documented HMA appear to have recovered from their growth failure and have normal cognitive development. They may, however, be at risk for deficits in language skills that require expressive language abilities. KW - alkalosis KW - Children KW - chloride KW - deficiency KW - infant formulae KW - soyabean products KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - infant formula KW - infant formulas KW - soybean products KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911438594&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Early formula supplementation of breast-feeding. AU - Kurinij, N. AU - Shiono, P. H. JO - Pediatrics JF - Pediatrics Y1 - 1991/// VL - 88 IS - 4 SP - 745 EP - 750 SN - 0031-4005 AD - Kurinij, N.: Collaborative Clinical Research Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19921442451. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - Factors influencing early formula supplementation in breast-fed neonates were examined among 726 women who were delivered of their first child in 1 of 3 metropolitan Washington, DC, USA, hospitals. Of breast-fed neonates 37% were given supplementary formula in the hospital. Mothers who gave birth at a university hospital were more likely to breast-feed exclusively (adjusted odds ratio 3.5; 95% confidence limit 2.1 to 5.9), after adjustment for maternal demographics, hospital factors and the maternal breast-feeding commitment. Aside from delivery hospital, a strong predictor of formula use was the time between birth and initiation of the first breast-feed. The longer a mother waited to initiate breast-feeding the more likely she was to use formula; the adjusted odds ratios for women who initiated breast-feeding 2 to 6 h, 7 to 11 h, and 12 or more h post partum were 1.1, 0.5, and 0.2, respectively. Feeding the baby on demand, having a vaginal delivery, deciding to breast-feed before pregnancy, having a college education and being married also were moderately, though significantly, predictive of exclusive breast-feeding. The findings suggest that hospital influences can promote formula use and indirectly shorten breast-feeding duration, particularly those hospital practices that delay early initiation of breast-feeding. KW - breast feeding KW - Cows KW - Infant feeding KW - infant formulae KW - infants KW - supplementary feeding KW - supplements KW - USA KW - cattle KW - Man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - infant formula KW - infant formulas KW - United States of America KW - Animal Nutrition (General) (LL500) KW - Diet Studies (VV110) KW - Milk and Dairy Produce (QQ010) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442451&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Malaria parasite chitinase and penetration of the mosquito peritrophic membrane. AU - Huber, M. AU - Cabib, E. AU - Miller, L. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1991/// VL - 88 IS - 7 SP - 2807 EP - 2810 SN - 0027-8424 AD - Huber, M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920506418. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 1398-61-4, 9001-06-3. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Malaria parasites (ookinetes) appear to digest the peritrophic membrane in the mosquito midgut during penetration. Previous studies demonstrated that lectins specific for N-acetylglucosamine bind to the peritrophic membrane and proposed that the membrane contains chitin [see W. Rudin & H. Hecker (1989) Parasitology Research, 75: 268-279]. In the present study, it was shown that the peritrophic membrane of Aedes aegypti (Liverpool/black eye strain) is digested by Serratia marcescens chitinase (EC 3.2.1.14), leading to the release of N-acetylglucosamine and fragmentation of the membrane. The presence is also reported of a malaria parasite chitinase that digests 4-methylumbelliferyl chitotriose. The enzyme is not detectable until 15 h after zygote formation, the time required for maturation of the parasite (Plasmodium gallinaceum 8A strain) from a zygote to an ookinete, the invasive form of the parasite. At 20 h, the enzyme begins to appear in the culture supernatant. The chitinase extracted from the parasite and found in the culture supernatant consists of a major band and 2 minor bands of activity on native polyacrylamide gel electrophoresis. The presence of chitin in the peritrophic membrane, the disruption of the peritrophic membrane during invasion, and the presence of chitinase in ookinetes suggest that the chitinase in ookinetes is used in the penetration of the peritrophic membrane. KW - Chitin KW - Chitinase KW - disease vectors KW - Enzymes KW - host parasite relationships KW - infections KW - Ookinetes KW - parasites KW - Peritrophic membrane KW - Vectors KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - parasite host relationships KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920506418&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infectious RNA transcribed from stable cloned full-length cDNA of dengue type 4 virus. AU - Lai, C. J. AU - Zhao, B. AU - Hori, H. AU - Bray, M. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1991/// VL - 88 IS - 12 SP - 5139 EP - 5143 SN - 0027-8424 AD - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920506837. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Medical & Veterinary Entomology N2 - Successful cloning is described of a stable full-length cDNA copy of dengue type 4 virus that can be used as the template for in vitro transcription of infectious RNA. Evidence is presented that dengue virus recovered from permissive cells transfected with the in vitro RNA transcripts retained a mutation that was engineered into full-length cDNA. The properties of the virus produced by cells transfected with infectious RNA transcripts of dengue cDNA resembled those of the virus from which the cDNA clone was derived. The dengue virus recombinant DNA system should prove helpful in gaining a better understanding of the molecular biology of dengue viruses and should facilitate the development of a safe and effective live vaccine for use in humans. KW - Arboviruses KW - DNA KW - Molecular genetics KW - RNA KW - transcription KW - Dengue virus KW - Flaviviridae KW - Flavivirus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA transcription KW - ribonucleic acid KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920506837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni. AU - Brindley, P. J. AU - Heath, S. AU - Waters, A. P. AU - McCutchan, T. F. AU - Sher, A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1991/// VL - 88 IS - 17 SP - 7754 EP - 7758 SN - 0027-8424 AD - Brindley, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878570. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 3105-97-3. Subject Subsets: Helminthology N2 - Stable resistance to hycanthone can be produced in S. mansoni by exposing immature parasites in mice to the drug. Within a single generation, genomic rearrangements, detected as rRNA-encoding DNA restriction fragment length polymorphisms (RFLPs), accompany the appearance of resistance in this model. One of these RFLPs, an ~3.6-kilobase BamHI fragment, has been shown previously to associate consistently with resistance in independent generations of the JHU strain of S. mansoni. To characterize the genetic changes responsible for this RFLP, the fragment was cloned and sequenced. A comparison of the cloned fragment with a normal 18S rRNA gene demonstrated that the drug resistance-associated RFLP fragment arises through the addition of 732 base pairs into an 18S rRNA gene, 134 base pairs downstream of the junction of the intergenic spacer and the mature 18S rRNA gene. The mutation is nonrandom, targets one, or a few only, of the 100 or so copies of the ribosomal genes, and may represent the incomplete duplication of the gene since the inserted element is identical in sequence to the region contiguous to it. The sequence spanning the junction of the insertion and the original 18S rRNA gene was used as a specific primer for the BamHI RFLP in PCR experiments. The analysis conclusively demonstrated that the mutation is induced rather than selected by the drug since the junctional sequence was not detectable in the drug-sensitive parent population of schistosomes. In addition, analysis of 4, independently derived, resistant lines indicated that the same region of the gene was mutated each time. Together, these data demonstrate that reproducible changes are induced during the acquisition of resistance in schistosomes and suggest that the resistant phenotype is induced rather than selected from preexisting forms. KW - drug resistance KW - Genes KW - helminths KW - Human diseases KW - hycanthone KW - Molecular genetics KW - parasites KW - Resistance mechanisms KW - Restriction fragment length polymorphism KW - Digenea KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - biochemical genetics KW - parasitic worms KW - RFLP KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878570&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The era of aerosol pentamidine prophylaxis: the beginning or the end. AU - Falloon, J. AU - Masur, H. T2 - American Journal of Medicine JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1991/// VL - 90 IS - 4 SP - 415 EP - 417 SN - 0002-9343 AD - Falloon, J.: Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19930883110. Publication Type: Editorial. Language: English. Number of References: 10 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - This editorial looks at the history of aerosolized pentamidine as prophylaxis for Pneumocystis carinii pneumonia in immunocompromised patients from the first trial to the present day. Published studies suggest that both the original Respirgard and the newer Fisons ultrasonic nebulisers can be used to effectively decrease the relapse rate of P. carinii pneumonia. It is now suggested that a direct trial comparing the performance of the two nebuliser systems is needed to compare performance. KW - aerosols KW - antiprotozoal agents KW - human diseases KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pentamidine KW - prophylaxis KW - respiratory diseases KW - reviews KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - fungus KW - lung diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883110&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals. AU - Huff, J. AU - Bucher, J. AU - Yang, R. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1991/// VL - 90 SP - 127 EP - 132 SN - 0091-6765 AD - Huff, J.: National Institute of Environmental health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19931459117. Publication Type: Journal Article. Language: English. Number of References: 101 ref. Subject Subsets: Human Nutrition N2 - Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor, Massachusetts, USA, was found to have visible liver neoplasms; winter flounder outside the estuary area had no liver lesions. Long-term chemical carcinogenesis studies could be easily and feasibly designed using laboratory rodents offered diets containing fish caught in polluted waters. Induced neoplasms in rodents would corroborate field observations in fish; positive results from these studies would provide further evidence about potential human health hazards from eating substantial amounts of chemically contaminated fish. Nonetheless, fish and aquatic organisms should be viewed as environmental biological monitors of pollution or of potential human health hazards, and authorities responsible for assuring clean and safe rivers, bodies of water and biota should give more attention to these valid biological indicators or sentinels of environmental pollution. Consequently, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards. KW - carcinogenesis KW - carcinogens KW - Pollution KW - risk KW - Seafoods KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - environmental pollution KW - Pollution and Degradation (PP600) KW - Aquatic Produce (QQ060) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increasing use of soy foods and their potential role in cancer prevention. AU - Messina, M. AU - Messina, V. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1991/// VL - 91 IS - 7 SP - 836 EP - 840 SN - 0002-8223 AD - Messina, M.: Diet and Cancer Branch, Division of Cancer Prevention & Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19920751443. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Soyabeans; Human Nutrition N2 - The possible role of soyabeans in cancer prevention is discussed. Diets composed of 5% (wt./wt.) soyabeans significantly inhibited induced mammary cancer in rats; this is thought to be due to anticarcinogenic compounds, isoflavones, contained in appreciable amounts in soyabeans. Protease inhibitors are identified as preventing promotion of experimentally induced breast and colon cancer. Specific protease inhibitors contained in soyabeans are discussed. Results of epidemiological studies are reviewed and the increasing consumption of traditional soya foods (tofu, soya milk) and second-generation soya foods is highlighted. KW - Carcinoma KW - diet treatment KW - neoplasms KW - prevention KW - proteinase inhibitors KW - reviews KW - Soyabean products KW - soyabeans KW - Glycine (Fabaceae) KW - Man KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - cancers KW - diet prescription KW - protease inhibitors KW - soybean products KW - soybeans KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Crop Produce (QQ050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920751443&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Healthy people 2000: development of nutrition objectives. AU - Danford, D. E. AU - Stephenson, M. G. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1991/// VL - 91 IS - 12 SP - 1517 EP - 1519 SN - 0002-8223 AD - Danford, D. E.: Division of Nutrition Research Coordination, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931459572. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition N2 - The Healthy People 2000 report sets national objectives in health promotion and disease prevention for the year 2000. The dietetic profession must strive to achieve goals for improved public health, especially nutritionally related ones. Through planned implementation of these developments into dietitian programmes health objectives can be achieved by the end of the decade and the role of dietitian in applying nutrition can be expanded. KW - dietitians KW - Nutrition programmes KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - feeding programmes KW - feeding programs KW - food programs KW - nutrition programs KW - United States of America KW - Animal Nutrition (Production Responses) (LL520) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459572&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Late recurrent Candida endocarditis. AU - Johnston, P. G. AU - Lee, J. AU - Domanski, M. AU - Dressler, F. AU - Tucker, E. AU - Rothenberg, M. AU - Cunnion, R. E. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Chest JF - Chest Y1 - 1991/// VL - 99 IS - 6 SP - 1531 EP - 1533 SN - 0012-3692 AD - Johnston, P. G.: T. J. Walsh, Pediatric Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210402. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 31-yr-old man in whom late recurrent C. albicans endocarditis (LRCE) developed on a prosthetic mitral valve 22 months after treatment for primary native mitral valve endocarditis. The LRCE was difficult to diagnose; results of 2 dimensional echocardiography and repeated blood cultures were negative. Only transoesophageal echocardiography revealed a vegetation and only lysis centrifugation blood cultures demonstrated candidaemia. Postmortem examination revealed a large Candida vegetation of the prosthetic valve, Candida in the mitral valve ring and fungal lesions in the liver, spleen and kidneys. A review of previously reported cases of LRCE indicated that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that LRCE, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy. KW - generalized infections KW - heart KW - hosts KW - infections KW - predisposition KW - prostheses KW - USA KW - Candida albicans KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungus KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Cerebral malaria: the unsolved riddle. AU - Román, G. C. T2 - Journal of the Neurological Sciences JO - Journal of the Neurological Sciences JF - Journal of the Neurological Sciences Y1 - 1991/// VL - 101 IS - 1 SP - 1 EP - 6 SN - 0022-510X AD - Román, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808639. Publication Type: Editorial. Language: English. Number of References: 49 ref. KW - Cerebral malaria KW - Pathogenicity KW - Pathology KW - Reviews KW - Apicomplexa KW - Man KW - Plasmodiidae KW - Plasmodium falciparum KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Neuropathology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808639&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cockroaches (Blatta and Periplaneta species) as reservoirs of drug-resistant salmonellas. AU - Devi, S. J. N. AU - Murray, C. J. JO - Epidemiology and Infection JF - Epidemiology and Infection Y1 - 1991/// VL - 107 IS - 2 SP - 357 EP - 361 SN - 0950-2688 AD - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920511923. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A total of 221 cockroaches (Blatta and Periplaneta spp. [not identified to species]) collected in hospitals, houses, animal sheds, grocery stores and restaurants in various parts of South Kanara District, Karnataka, India, were studied bacteriologically for the presence of salmonellas. Salmonellas were isolated from 4.1% of these cockroaches. 9 strains of salmonellas were recovered, belonging to 5 serotypes: Salmonella bovismorbificans, S. oslo, S. typhimurium, S. mbandaka and S. braenderup, the former 2 being the commonest serotypes. All salmonellas were resistant to one or other of 11 antibacterial drugs used in a susceptibility test. Isolation of salmonellas from cockroaches collected from livestock premises and human dwellings suggested that they may act as significant reservoirs of Salmonella in nature. Recovery of serotypes, phage types and R-types that were commonly isolated from humans and animals in the area [see also Arogya Journal of Health Sciences, 15: 80-84 (1989) and Indian Journal of Medical Sciences, 40: 177-178 (1986)] suggested a transmission role for cockroaches. By harbouring potentially pathogenic, drug-resistant salmonellas, these wandering arthropods may pose dangerous infective hazards to humans and animals. KW - Animal housing KW - Antibiotics KW - buildings KW - Cattle housing KW - Disease vectors KW - Drug resistance KW - Hospitals KW - Livestock KW - mechanical transmission KW - Restaurants KW - Asia KW - India KW - Karnataka KW - Bacteria KW - Blatta orientalis KW - Blattaria KW - Blattidae KW - Dictyoptera KW - Enterobacteriaceae KW - Periplaneta americana KW - Salmonella KW - Salmonella typhimurium KW - prokaryotes KW - Blatta KW - Blattidae KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - Periplaneta KW - Enterobacteriaceae KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - American cockroach KW - bacterium KW - Blattodea KW - cattle sheds KW - Mysore KW - Oriental cockroach KW - Salmonella bovismorbificans KW - Salmonella braenderup KW - Salmonella mbandaka KW - Salmonella oslo KW - Animal Husbandry (General) (LL100) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511923&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National education programs working group report on the management of patients with hypertension and high blood cholesterol. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1991/// VL - 114 IS - 3 SP - 224 EP - 237 SN - 0003-4819 AD - E. J. Rocella, National Heart, Lung and Blood Institute, Building 31, Room 4A05, Bethesda, MD 20892, USA. N1 - Accession Number: 19911438163. Publication Type: Journal Article. Corporate Author: USA, Working Group on Management of Patients with Hypertension and High Blood Cholesterol Language: English. Number of References: 89 ref. Subject Subsets: Human Nutrition N2 - This position paper addresses prevention of morbidity and mortality from cardiovascular disease. It provides clinicians (and programmes) with an integrated approach to identification and management of patients with several cardiovascular risk factors, emphasizing hypertension and high blood cholesterol. Non-pharmacologic therapy, in the form of a proper diet, exercise, and smoking cessation, is recognized as the foundation for management of both hypertension and high blood cholesterol. It is suggested that clinicians should use these non-drug measures as definitive or adjunctive therapy. Pharmacologic agents have been found to be very beneficial in managing the risks imposed by high levels of blood pressure or blood cholesterol. In selecting medications, their benefits, costs, and potential untoward effects should be considered. Advice is given that clinicians consider these issues in managing patients with several risk factors. Potential for adverse effects should not preclude dismissing any particular mode of therapy or managing any risk factor. KW - cardiovascular diseases KW - diet treatment KW - Hypercholesterolaemia KW - Hypertension KW - prevention KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diet prescription KW - high blood pressure KW - hypercholesterinemia KW - hypercholesterolemia KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911438163&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cardiopulmonary toxicity after liposomal amphotericin B infusion. AU - Levine, S. J. AU - Walsh, T. J. AU - Martinez, A. AU - Eichacker, P. Q. AU - Lopez-Berestein, G. AU - Natanson, C. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1991/// VL - 114 IS - 8 SP - 664 EP - 666 SN - 0003-4819 AD - Levine, S. J.: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911208946. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - A case is reported in a 22-yr-old woman receiving high dose (5 mg/kg daily) liposomal amphotericin B (L-AmpB) for hepatosplenic Candida infection who developed reversible abnormalities in pulmonary gas exchange and cardiopulmonary haemodynamics. KW - administration KW - amphotericin B KW - Antifungal agents KW - candidosis KW - hosts KW - infections KW - liposomes KW - liver KW - spleen KW - therapy KW - toxicity KW - treatment KW - USA KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - amphotercin B KW - candidiasis KW - cardiopulmonary KW - fungistats KW - fungus KW - Hyphomycetes KW - reactions KW - therapeutics KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208946&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunolocalization of myosin I heavy chain kinase in Acanthamoeba castellanii and binding of purified kinase to isolated plasma membranes. AU - Kulesza-Lipka, D. AU - Baines, I. C. AU - Brzeska, H. AU - Korn, E. D. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1991/// VL - 115 IS - 1 SP - 109 EP - 119 SN - 0021-9525 AD - Kulesza-Lipka, D.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910875850. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activities of Acanthamoeba myosins I are known to be maximally expressed only when a single threonine (myosin IA) or serine (myosins IB and IC) is phosphorylated by myosin I heavy chain kinase. The purified kinase is highly activated by autophosphorylation and the rate of autophosphorylation is greatly enhanced by the presence of acidic phospholipids. It was shown by immunofluorescence and immunoelectron microscopy of permeabilized cells that myosin I heavy chain kinase is highly concentrated, but not exclusively, at the plasma membrane. Judged by their electrophoretic mobilities, kinase associated with purified plasma membranes may differ from the cytoplasmic kinase, possibly in the extent of its phosphorylation. Purified kinase binds to highly purified plasma membranes with an apparent KD of ~17 nM and a capacity of ~0.8 nmol/mg of plasma membrane protein, values that are similar to the affinity and capacity of plasma membranes for myosins I. Binding of kinase to membranes is inhibited by elevated ionic strength and by extensive autophosphorylation but not by substrate-level concentrations of ATP. Membrane-bound kinase autophosphorylates to a lesser extent than free kinase and does not dissociate from the membranes after autophosphorylation. The co-localization of myosin I heavy chain kinase and myosin I at the plasma membrane is of interest in relation to the possible functions of myosin I especially as phospholipids increase kinase activity. KW - Biochemistry KW - enzymes KW - Human diseases KW - Kinases KW - Membranes KW - myosins KW - parasites KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875850&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The child with cancer and infection. II. Nonbacterial infections. AU - Pizzo, P. A. AU - Rubin, M. AU - Freifeld, A. AU - Walsh, T. J. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1991/// VL - 119 IS - 6 SP - 845 EP - 857 SN - 0022-3476 AD - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211568. Publication Type: Journal Article. Language: English. Number of References: 105 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The advances and the problems that relate to the diagnosis and treatment of infectious complications in paediatric cancer patients are reviewed. Invasive fungal infections, including oropharyngeal, oesophageal and hepatosplenic infections and fungaemia due to Candida, and infections caused by Aspergillus, Cryptococcus neoformans, Trichosporon, agents of mucormycosis, Pseudallescheria boydii, Fusarium and dematiaceous fungi, viruses and Pneumocystis carinii are discussed. KW - Antifungal agents KW - blood KW - children KW - infections KW - liver KW - mouth KW - neoplasms KW - oesophagus KW - pharynx KW - predisposition KW - spleen KW - therapy KW - ZYGOMYCOSIS KW - Aspergillus KW - Candida KW - Cryptococcus neoformans KW - Fusarium KW - man KW - Pseudallescheria boydii KW - Trichosporon KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporonaceae KW - cancers KW - esophagus KW - fungistats KW - fungus KW - Hyphomycetes KW - phycomycosis KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii pneumonia despite prophylaxis in children with human immunodeficiency virus infection. AU - Mueller, B. U. AU - Butler, K. M. AU - Husson, R. N. AU - Pizzo, P. A. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1991/// VL - 119 IS - 6 SP - 992 EP - 994 SN - 0022-3476 AD - Mueller, B. U.: P.A. Pizzo, Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19920881470. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - Six children with HIV infection are reported who developed Pneumocystis carinii pneumonia (PCP) while receiving prophylaxis. The prophylaxis was either pentamidine (intravenous or aerosolized) or trimethoprim/sulfamethoxazole. This study suggests that although reports support the efficacy of TMP/SMX prophylaxis with virtually no occurrences of PCP, clinicians taking care of a child with an HIV infection who has respiratory symptoms must maintain a high index of suspicion for the possibility of PCP, even if the child is receiving prophylaxis. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiprotozoal agents KW - case reports KW - children KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pentamidine KW - prophylaxis KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - trimethoprim sulfamethoxazole KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881470&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estimating the relation between dietary intake obtained from a food frequency questionnaire and true average intake. AU - Freedman, L. S. AU - Carroll, R. J. AU - Wax, Y. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1991/// VL - 134 IS - 3 SP - 310 EP - 320 SN - 0002-9262 AD - Freedman, L. S.: Biometry Branch, DCPC, National Cancer Institute, Executive Plaza North, Suite 344, Bethesda, MD 20892, USA. N1 - Accession Number: 19911439183. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition N2 - Knowledge of the regression relation between dietary intake reported on a food frequency questionnaire and true average intake is useful in interpreting results from nutritional epidemiologic studies and in planning such studies. Studies which validate a questionnaire against a food record may be used to estimate this regression relation provided the food record is completed by each subject on at least 2 occasions. Using data collected from women 45-69 years old during 1985-1986 in the pilot study of the Women's Health Trial, it is shown how variation in diet over time and intraindividual correlation between a questionnaire and food record obtained close together in time affects the estimation of the regression. The method presented provides estimates of the regresssion slope and the questionnaire "bias" that are corrected for these effects, together with standard errors. A computer programme in the SAS language, for carrying out the analysis, is provided. KW - estimation KW - Food intake KW - questionnaires KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911439183&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A case-control study of nutrient status and invasive cervical cancer. 2. Serologic indicators. AU - Potischman, N. AU - Herrero, R. AU - Brinton, L. A. AU - Reeves, W. C. AU - Stacewicz-Sapuntzakis, M. AU - Jones, C. J. AU - Brenes, M. M. AU - Tenorio, F. AU - Britton, R. C. de AU - Gaitan, E. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1991/// VL - 134 IS - 11 SP - 1347 EP - 1355 SN - 0002-9262 AD - Potischman, N.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19921443982. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - To investigate the hypothesis that lower serum values of 8 micronutrients were associated with a higher risk of invasive cervical cancer, 387 patients and 670 controls from 4 Latin American countries were studied. Serologic analyses were restricted to a sample of subjects with stage I and stage II disease to minimise effects of the disease on the serologic markers. 94% of eligible subjects donated blood samples, which were analysed for carotenoids, retinol and tocopherols by high-pressure liquid chromatography. Cases did not differ significantly from controls in mean serum concentrations of retinol, cryptoxanthin, lycopene, α-carotene, lutein, or α-tocopherol. Mean β-carotene was lower and mean γ-tocopherol was higher among cases compared with controls. After adjustment for age, study site, sexual and reproductive behaviour, socioeconomic status, screening practices, detection of human papillomavirus types 16/18, cholesterol, and triacylglycerols, a trend of decreasing risk was associated with higher β-carotene values (P for trend = 0.05), with the adjusted odds ratio decreasing to 0.72 for the highest versus the lowest quartile. β-Carotene results were similar by stage of disease, which argues against an effect of disease progression on nutrient values. Unexpectedly, increasing risks were observed as the concentration of γ-tocopherol increased (odds ratio = 2.09; P for trend = 0.03); however, values were higher among stage II cases compared with stage I cases, suggesting a metabolic alteration resulting from the disease process. The results support a role for β-carotene or foods rich in β-carotene in the aetiology of cervical cancer and indicate that simultaneous analysis using serologic and dietary nutrient indicators allows better discrimination of the association. KW - Carcinoma KW - carotenoids KW - cervix KW - nutritional state KW - retinol KW - tocopherols KW - Latin America KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - axerophthol KW - nutritional status KW - tetraterpenoids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443982&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of aerosolized pentamidine prophylaxis on the diagnosis of Pneumocystis carinii pneumonia by induced sputum examination in patients infected with the human immunodeficiency virus. AU - Levine, S. J. AU - Masur, H. AU - Gill, V. J. AU - Feuerstein, I. AU - Suffredini, A. F. AU - Brown, D. AU - Lane, H. C. AU - Yarchoan, R. AU - Shelhamer, J. H. AU - Ognibene, F. P. AU - Ognibene, F. P. JO - American Review of Respiratory Disease JF - American Review of Respiratory Disease Y1 - 1991/// VL - 144 IS - 4 SP - 760 EP - 764 SN - 0003-0805 AD - Levine, S. J.: F.P. Ognibene, Critical Care Medicine Department, Building 10, Room 7-D43, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920876102. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - The effect of aerosolized pentamidine prophylaxis on the clinical presentation and diagnostic sensitivity of induced sputum examination for P. carinii pneumonia PCP. Between January 1988 and October 1990, 348 induced sputum examinations were performed as the initial diagnostic procedure for PCP in HIV positive patients at the NIH, Maryland, USA. Medical records were reviewed for all induced sputum examinations, and the study group consisted of patients who either had not received prophylactic therapy (n = 193) or had received aerosolized pentamidine prophylaxis (n = 126). A total of 29 induced sputum examinations in patients receiving other prophylactic regimens or ongoing therapy for previously documented PCP were excluded from the study group. A total of 72 consecutive episodes of PCP were subsequently documented by induced sputum examination (n = 54), bronchoalveolar lavage (n = 16), thoracocentesis (n = 1), or autopsy (n = 1). A total of 44 episodes occurred in patients who had not received antipneumocystis prophylaxis, and 28 episodes occurred in patients who had received aerosolized pentamidine. Of patients capable of producing a sputum specimen for analysis, induced sputum examination had a significantly lower diagnostic yield of 64.3% in patients who had received aerosolized pentamidine prophylaxis compared with 92.3% in patients who did not receive prophylaxis. When the data were analyzed on an intention to treat basis, although there was a trend suggesting a lower overall yield in the aerosolized pentamidine-treated patients, the difference was not statistically significant (64.3 versus 81.8%). There was no significant difference in duration of symptoms, alveolar-arterial oxygen gradient, presenting radiographic manifestations, or burden of organisms (in patients with positive induced sputum examinations) between the 2 groups. However, there was a trend toward an increased incidence of focal upper lobe infiltrates in the aerosolized pentamidine group. It is concluded that aerosolized pentamidine prophylaxis is associated with a significantly lower diagnostic yield (64.3%) of induced sputum examination for PCP in HIV-infected patients if a specimen is obtained for analysis. Nevertheless, its yield is high enough such that an induced sputum examination should still be considered the initial diagnostic procedure for suspected PCP in these patients. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - aerosols KW - Antiprotozoal agents KW - clinical aspects KW - diagnosis KW - HIV infections KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - Pentamidine KW - Pneumocystis carinii pneumonia KW - prophylaxis KW - Sputum KW - Maryland KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Sensitivity KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876102&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. AU - Grzych, J. M. AU - Pearce, E. AU - Cheever, A. AU - Caulada, Z. A. AU - Caspar, P. AU - Heiny, S. AU - Lewis, F. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1991/// VL - 146 IS - 4 SP - 1322 EP - 1327 SN - 0022-1767 AD - Grzych, J. M.: A Sher, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910873178. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - To characterize Th cell populations induced by helminth infection, spleen cells from C3H/HeN mice infected with Schistosoma mansoni (NMRI strain) were stimulated with parasite (worm or ovum antigen) or mitogen (Con A) and the supernatants assayed for the Th1-specific cytokines IFN-γ and IL-2 and the Th2-specific cytokines IL-4 and IL-5. Th2 cytokine production was not detected in substantial quantity until the 6th to 8th week of infection and after reaching peak levels at 8 to 12 weeks declined slowly thereafter. The time courses of IL-4 and IL-5 production, although differing from each other, closely resembled corresponding published data on IgE and peripheral blood eosinophil levels during murine schistosome infection. In contrast, Th1 cytokine responses occurred only during the first 6 weeks of infection and were virtually absent during the peak period of Th2 production. To assess the role of ovum deposition in the observed pattern of Th response, cytokine production was assayed in mice carrying unisexual schistosome infections in which parasite ova are absent. Splenocytes from these animals displayed only marginal Th2 cytokine synthesis but greater Th1 cytokine responses than the corresponding cells from mice with bisexual infections. Moreover, cultures of liver tissue or isolated granulomata from infected mice constitutively produced high levels of IL-4 and IL-5 but failed to synthesize significant amounts of IL-2 and IFN-γ even when stimulated with ovum antigen or mitogen. Taken together the data indicate that ova deposition is the major stimulus of Th2 cytokine response in S. mansoni-infected mice and suggest that T cells belonging to this subset play a major role in egg granuloma formation. KW - Cytokines KW - Developmental stages KW - helminths KW - Human diseases KW - immune response KW - interferon KW - interleukins KW - Laboratory animals KW - ova KW - parasites KW - Digenea KW - mice KW - Rodents KW - Schistosoma mansoni KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - growth phase KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910873178&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels. AU - King, C. L. AU - Poindexter, R. W. AU - Ragunathan, J. AU - Fleisher, T. A. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1991/// VL - 146 IS - 5 SP - 1478 EP - 1483 SN - 0022-1767 AD - King, C. L.: Laboratory of Parasitic Diseases, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874091. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 37341-29-0. Subject Subsets: Helminthology N2 - The immunoregulatory mechanisms that determine the high serum IgE antibody levels in disorders such as helminth parasite infections and the hyper-IgE recurrent infection syndrome (HIE) remain poorly understood. To assess whether elevated serum IgE levels result from an increased number of B lymphocytes committed to IgE production, the proportion of IgE-producing B lymphocytes was determined by a filter immunoplaque assay using peripheral blood mononuclear cells (PBMC) from persons with a broad range of serum IgE levels that included normal persons (n = 9) and patients with loiasis (n =12), tropical pulmonary eosinophilia (TPE) (n = 6), lymphatic filariasis caused by Wuchereria bancrofti (n = 28), and hyper-IgE recurrent infection syndrome (HIE, n = 8). PBMC from these persons were assessed for production of in vitro IgE. The geometric mean number of IgE-secreting cells in 105 B lymphocytes in PBMC was 0.42 (range 0-2.2) in normal persons, 5.6 (range 0.1-35.5) among patients with loiasis, 9.4 (range 0-53.2) among patients with lymphatic filariasis, 52 (range 31.5-115) among patients with TPE, and 218 (range 56-1404) among patients with HIE. When all study subjects were grouped, there were significant correlations with serum IgE levels and net spontaneous in vitro IgE production. Estimates of the amount of IgE production per B lymphocyte were similar among normal persons, patients with filarial infections, and patients with TPE (geometric means of 134, 96, and 141 pg/ml/cell, respectively); in contrast, for HIE patients, IgE production by individual B cells was significantly lower (geometric mean 28 pg/ml/cell). These observations demonstrate that clonal expansion of IgE-producing B lymphocytes is a major mechanism underlying the elevated serum IgE levels seen in persons with hyper-IgE states. KW - Antibodies KW - B lymphocytes KW - Filariasis KW - Filariids KW - helminths KW - Human diseases KW - IgE KW - immune response KW - parasites KW - Loa loa KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Wuchereria KW - African eyeworm KW - B cells KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. AU - Sher, A. AU - Fiorentino, D. AU - Caspar, P. AU - Pearce, E. AU - Mosmann, T. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1991/// VL - 147 IS - 8 SP - 2713 EP - 2716 SN - 0022-1767 AD - Sher, A.: National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920876010. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Helminthology N2 - After the onset of parasite egg deposition, mice infected with Schistosoma mansoni mount strong Th2 cytokine responses in the absence of significant Th1 cytokine synthesis. To examine the basis of this immunoregulatory state, spleen or lymph node cells from schistosome-infected mice were stimulated with parasite-specific antigen (Ag) and the supernatants tested for their capacity to suppress interferon (IFN-γ) synthesis by a Th1 cell line. Strong inhibition was observed that was neutralized by a MAb against IL-10, a cytokine previously shown to down-regulate Th1 cytokine synthesis. By means of ELISA measurements the production of IL-10 in schistosome infection was confirmed and shown to depend on CD4+ T cells. IL-10 synthesis stimulated by either mitogen or Ag was observed only at those stages of infection when Th2 response induction and Th1 cytokine down-regulation also occurred and was not detected in mice vaccinated with attenuated parasites. Moreover, the addition of the neutralizing anti-IL-10 MAb to Ag-stimulated spleen cell cultures from infected mice caused a dramatic augmentation in IFN-γ synthesis. These findings suggest that IL-10 is responsible for the down-regulation of Th1 responses observed in schistosome infections. KW - Cytokines KW - helminths KW - immune response KW - Interleukins KW - Laboratory animals KW - parasites KW - T lymphocytes KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876010&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of host cell-derived membrane proteins of the vacuole surrounding different intracellular forms of Trypanosoma cruzi in J774 cells. AU - Hall, B. F. AU - Furtado, G. C. AU - Joiner, K. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1991/// VL - 147 IS - 12 SP - 4313 EP - 4321 SN - 0022-1767 AD - Hall, B. F.: Parasitology and Tropical Medicine Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19920877101. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Protozoology N2 - T. cruzi exhibits developmental regulation of virulence. Although both noninfective epimastigote and infective trypomastigote stages of T. cruzi enter phagocytic cells via the formation of a parasitophorous vacuole (PV), only the latter developmental stages survive ingestion and perpetuate the infection. To determine whether the membrane composition of PV surrounding these different stages might contribute to differences in the outcome of infection, selected membrane constituents were identified by immunofluorescence and intracellular radioiodination, and their incorporation into PV was studied. Complement receptors (CR3) were incorporated preferentially into the PV membrane surrounding serum-opsonized epimastigotes but not culture-derived metacyclic trypomastigotes. FcR were not preferentially incorporated into PV membranes unless epimastigotes or culture-derived metacyclic trypomastigotes were opsonized with anti-T. cruzi antibody. PV surrounding either parasite stage contain β1 integrins and lysosomal membrane glycoproteins (lgp). These results indicate that the plasma membrane glycoproteins incorporated into the surrounding PV membrane differ depending upon the stage of parasite being internalized, and that these differences reflect, at least in part, selective ligation of cell surface receptors mediating uptake. Furthermore, they imply that although virulent trypomastigote stages may avoid host cell uptake by conventional phagocytic receptors, i.e., CR3 or FcR, they do not escape fusion with an lgp-containing vacuole where they could still be exposed to lysosomal antimicrobial mechanisms. KW - Cell invasion KW - Cell membranes KW - host parasite relationships KW - Human diseases KW - parasites KW - phagocytes KW - Vacuoles KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877101&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Change in cholesterol awareness and action. Results from national physician and public surveys. AU - Schucker, B. AU - Wittes, J. T. AU - Santanello, N. C. AU - Weber, S. J. AU - McGoldrick, D. AU - Donato, K. AU - Levy, A. AU - Rifkind, B. M. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1991/// VL - 151 IS - 4 SP - 666 EP - 673 SN - 0003-9926 AD - Schucker, B.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Room 401, Federal Bldg, 7550 Wisconsin Ave, Bethesda, MD 20892, USA. N1 - Accession Number: 19931467394. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 57-88-5. N2 - The National Heart, Lung, and Blood Institute, USA sponsored national telephone surveys of practising physicians and the adult public in 1983, 1986 and 1990 to assess attitudes and practices regarding high serum cholesterol values. Each time, about 1600 physicians and 4000 adults were interviewed. Trends show continuing change in medical practice and public health behaviour relating to serum cholesterol. In 1990, physicians reported treating serum cholesterol at considerably lower values than in 1986 and 1983. The median range of serum cholesterol at which diet therapy was initiated was 5.17-5.66 mmol/litre (200 to 219 mg/dl) in 1990, down from 6.21-6.70 mmol/litre (240 to 259 mg/dl) in 1986 and 6.72-7.21 mmol/litre (260 to 279 mg/dl) in 1983. The median ranges for initiating drug therapy were 6.21-6.70 mmol/litre (240 to 259 mg/dl) in 1990, 7.76-8.25 mmol/litre (300 to 319 mg/dl) in 1986, and 8.79-9.28 mmol/litre (340 to 359 mg/dl) in 1983. The number of adults who reported having had their cholesterol checked was 35, 46 and 65% in 1983, 1986 and 1990, respectively. Between 1983 and 1990, the number of adults reporting a physician diagnosis of high serum cholesterol increased from 7 to 16%; the number reporting a prescribed cholesterol-lowering diet increased from 3 to 9%. Reports of self-initiated diet efforts reached a high of 19% in 1986, and decreased to 15% in 1990. 2% of adults reported drug prescriptions in 1990 compared with 1% in earlier years. In 1990, over 90% of physicians reported awareness and use of the recommendations from the Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment for High Blood Cholesterol in Adults, and the public reported marked increases in awareness of dietary methods to lower serum cholesterol. These changes suggest educational gains; the data also suggest areas for continued cholesterol educational initiatives. KW - Blood KW - Cholesterol KW - Diet treatment KW - Drug therapy KW - Hypercholesterolaemia KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - diet prescription KW - hypercholesterinemia KW - hypercholesterolemia KW - United States of America KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931467394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Amphotericin B vs high-dose ketoconazole for empirical antifungal therapy among febrile, granulocytopenic cancer patients. A prospective, randomized study. AU - Walsh, T. J. AU - Rubin, M. AU - Hathorn, J. AU - Gress, J. AU - Thaler, M. AU - Skelton, J. AU - McKnight, J. AU - Browne, M. AU - Marshall, D. AU - Cotton, D. AU - Hiemenz, J. AU - Longo, D. AU - Wesley, R. AU - Pizzo, P. A. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1991/// VL - 151 IS - 4 SP - 765 EP - 770 SN - 0003-9926 AD - Walsh, T. J.: Infectious Disease Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911209591. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 1397-89-3, 65277-42-1. Subject Subsets: Medical & Veterinary Mycology N2 - High-dose ketoconazole (800 mg/kg daily, orally) was compared with amphotericin B (0.5 mg/kg daily, intravenously) for empirical antifungal therapy in a prospective, randomized study of persistently or recurrently febrile granulocytopenic cancer patients. Among 97 patients eligible for empirical antifungal therapy, 20 (21%) of these patients were ineligible for randomization to ketoconazole treatment because of their inability to tolerate oral medications. Among 72 patients eligible for randomization, 64 were assessable (32 in each arm of the study). Fungal infections were diagnosed in 10 of these 64 patients and in 2 of the 20 non-randomized patients. Candida albicans, C. tropicalis, Aspergillus, A. niger and A. flavus were the causative agents. Five of 6 patients with proved fungal infections who were randomized to receive ketoconazole treatment required crossover to amphotericin B treatment because of progressive infection. The conditions of 3 of these 5 patients improved after receiving amphotericin B. The frequency of transaminase elevation was higher in those receiving ketoconazole, while the frequency of azotaemia was higher in those receiving amphotericin B. Bioavailability of ketoconazole was unpredictable. It is concluded that amphotericin B remains the drug of choice for empirical antifungal therapy in granulocytopenic patients, whereas lack of a parenteral formulation, ineffectiveness against proved mycoses and unreliable bioavailability preclude high-dose ketoconazole from being an appropriate compound for this purpose. KW - amphotericin B KW - Antifungal agents KW - hosts KW - infections KW - ketoconazole KW - predisposition KW - therapy KW - USA KW - Aspergillus KW - Aspergillus flavus KW - Aspergillus niger KW - Candida albicans KW - Candida tropicalis KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - therapeutics KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209591&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National Cholesterol Education Program. Report of the expert panel on population strategies for blood cholesterol reduction: executive summary. A2 - Dalen, J. E. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1991/// VL - 151 IS - 6 SP - 1071 EP - 1084 SN - 0003-9926 AD - National Coordinator, National Cholesterol Education Program, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921445691. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The Population Panel of the National Cholesterol Education Program (NCEP) USA, gives a set of recommendations designed to help healthy Americans decrease blood cholesterol by changes in eating patterns. Recommendations are aimed at individuals, special groups, health professionals, the food industry and government agencies as well as public and private education systems. KW - blood KW - cholesterol KW - nutrition education KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Human Nutrition (General) (VV100) KW - Education, Extension, Information and Training (General) (CC000) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445691&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vivo interferon-γ therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae. AU - Rex, J. H. AU - Bennett, J. E. AU - Gallin, J. I. AU - Malech, H. L. AU - DeCarlo, E. S. AU - Melnick, D. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1991/// VL - 163 IS - 4 SP - 849 EP - 852 SN - 0022-1899 AD - Rex, J. H.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19911210536. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 9008-11-1. Subject Subsets: Medical & Veterinary Mycology N2 - During a double-blind, placebo-controlled, randomized trial of recombinant interferon-γ (rIFN-γ) therapy in chronic granulomatous disease (CGD), a metabolic assay of neutrophil damage to A. fumigatus hyphae was used to monitor neutrophil function before and during therapy. In this assay, 5 × 104 conidia that had germinated into hyphae were exposed to 5 × 105, 15 × 105 or 50 × 105 CGD neutrophils. By analysis of variance, neutrophils from patients on rIFN-γ were found to produce significantly more damage to hyphae than those from the placebo group (P<0.01). In subgroup analysis, this effect was best seen in the hyphae exposed to 50 × 105 CGD neutrophils, where neutrophils from patients receiving rIFN-γ produced significantly more damage to the hyphae than those from the placebo group (P<0.05). It is concluded that in vivo rIFN-γ therapy improves the ability of CGD neutrophils to damage A. fumigatus hyphae in an in vitro assay. KW - immunology KW - interferon KW - neutrophils KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210536&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polyamine metabolism in Pneumocystis carinii. AU - Lipschik, G. Y. AU - Masur, H. AU - Kovacs, J. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1991/// VL - 163 IS - 5 SP - 1121 EP - 1127 SN - 0022-1899 AD - Lipschik, G. Y.: Critical Care Medicine Department, National Institutes of Health, Bldg. 10, Room 10D48, Bethesda, MD 20892, USA. N1 - Accession Number: 19910874229. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Protozoology N2 - To investigate polyamine metabolism in P. carinii, extracts of the organism were analyzed for polyamine content and ornithine decarboxylase activity, and [³H]ornithine and [14C]arginine incorporation into polyamines during short-term culture was determined. P. carinii extracts contained putrescine and spermidine in a ratio of 0.17:1; traces of spermine were detected. Although ornithine decarboxylase activity was not detected, P. carinii incorporated ornithine and arginine into putrescine and spermidine but not into spermine, suggesting that the spermine detected derived from contaminating host cells. Uninfected rat lung incorporated ornithine minimally. Pentamidine α-difluoromethylornithine, and α-monofluoromethyldehydroornithine methyl ester inhibited ornithine incorporation by up to 86% at clinically achievable concentrations. These data provide a rationale for using polyamine synthesis antagonists in P. carinii pneumonia and a method for screening anti-Pneumocystis drugs in vitro. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - antiinfective agents KW - Antiprotozoal agents KW - Biochemistry KW - in vitro KW - metabolism KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - polyamines KW - Treatment KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - AIDS KW - antimicrobials KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874229&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - β1,4-Oligoglucosides inhibit the binding of Aspergillus fumigatus conidia to human monocytes. AU - Kan, V. L. AU - Bennett, J. E. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1991/// VL - 163 IS - 5 SP - 1154 EP - 1156 SN - 0022-1899 AD - Kan, V. L.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210572. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The binding of A. fumigatus conidia to human monocytes was profoundly inhibited by a barley β-glucan. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1,3) and cellobiose (β1,4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1,4-linked glucose residues were more potent as specific inhibitors of this binding over similar concn. Increasing the number of β1,4-linked glucose residues led to greater inhibition of conidial binding by human monocytes. KW - binding KW - immunology KW - inhibition KW - monocytes KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210572&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection. AU - Markoff, L. J. AU - Innis, B. L. AU - Houghten, R. AU - Henchal, L. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1991/// VL - 164 IS - 2 SP - 294 EP - 301 SN - 0022-1899 AD - Markoff, L. J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930517856. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9001-91-6. Subject Subsets: Medical & Veterinary Entomology N2 - The 4 serotypes of dengue virus cause an acute febrile illness (dengue fever) or a more prolonged illness with plasma leakage resulting in hypovolaemia (dengue haemorrhagic fever). Haemorrhage may accompany either. Epidemiologic data suggest a role for dengue antibodies in pathogenesis. Computer analysis revealed a 20-residue region of similarity in amino acid sequence between the dengue type 4 envelope glycogen (E) and a family of clotting factors, including plasminogen, the prime mediator of fibrinolysis. By use of synthetic peptides in ELISA, E antibodies that potentially bind plasminogen were detected in 75% of 40 Thai patients acutely infected with dengue virus type 1, 2, 3 or 4. Plasminogen cross-reactivity of dengue antibodies was shown to be specific for the related sites in E and plasminogen. The dengue E sequence with similarity to plasminogen is largely conserved within the currently known flavivirus E sequences. However, 15 Thai patients hospitalized for illness caused by Japanese encephalitis virus (a flavivirus not associated with haemorrhage) did not develop plasminogen-cross-reactive antibodies, and this finding correlated with failure of Japanese encephalitis virus antibodies to bind to the plasminogen-cross-reactive site in E. KW - Antibodies KW - Arboviruses KW - Dengue KW - Human diseases KW - Immune response KW - Immunopathology KW - pathogenesis KW - Plasminogen KW - Viral diseases KW - Viral proteins KW - Thailand KW - Dengue virus KW - Flavivirus KW - Japanese encephalitis virus KW - man KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - arthropod-borne viruses KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - viral infections KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517856&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparative safety, tolerance, and pharmacokinetics of amphotericin B lipid complex and amphotericin B desoxycholate in healthy male volunteers. AU - Kan, V. L. AU - Bennett, J. E. AU - Amantea, M. A. AU - Smolskis, M. C. AU - McManus, E. AU - Grasela, D. M. AU - Sherman, J. W. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1991/// VL - 164 IS - 2 SP - 418 EP - 421 SN - 0022-1899 AD - Kan, V. L.: Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19911210513. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - Amphotericin B lipid complex (ABLC) and amphotericin B desoxycholate (AB, Fungizone) were compared for safety, tolerance and pharmacokinetics in 2 groups of 8 healthy male volunteers. After a 1-mg test dose, study drug was infused at 0.1, 0.25 and 0.5 mg/kg; the 0.5-mg/kg dose was not given to subjects receiving AB. ABLC caused few acute adverse effects except for mild somnolence in 6 volunteers. In addition, 3 of 8 ABLC recipients had asymptomatic, transient serum transaminase elevations that resolved spontaneously. The AB recipients experienced more acute side effects, but only 1 had a mild shaking chill; 3 of 8 also experienced sleepiness. No significant changes in vital signs, electrocardiograms, oximetry, pulmonary function or clinical status were observed in either group. Due to its increased estimated volume of distribution and estimated clearance, ABLC yielded decreased amphotericin B levels and area under the serum concentration versus time curve relative to AB. KW - administration KW - Amphotericin B KW - Antifungal agents KW - liposomes KW - pharmacokinetics KW - toxicity KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210513&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anemia and spontaneous preterm birth. AU - Klebanoff, M. A. AU - Shiono, P. H. AU - Selby, J. V. AU - Trachtenberg, A. I. AU - Graubard, B. I. JO - American Journal of Obstetrics and Gynecology JF - American Journal of Obstetrics and Gynecology Y1 - 1991/// VL - 164 IS - 1Pt1 SP - 59 EP - 63 AD - Klebanoff, M. A.: Division of Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, EPN 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19911436313. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition N2 - The association between anaemia during pregnancy and spontaneous preterm birth was studied using a large multiethnic cohort. Results of all haematological measurements were abstracted from prenatal and delivery records of 1706 of the 26 901 women. Among women who delivered infants at term, mean haematocrit value was low during the early phase of the second trimester, stable until near term, then reached a maximum at 40 weeks gestation. The mean haematocrit value of black women was lower than that of Asian, Mexican, and white women. Anaemia (haematocrit value less than the 10th percentile for ethnic group and duration of pregnancy) at any time during the second trimester was positively associated with subsequent spontaneous preterm birth (odds ratio, 1.9). Compared with white women, the odds ratio for preterm birth were 2.0 for black, 1.2 for Asian, and 1.2 for Mexican women. Adjustment for second-trimester anaemia had minimal influence on the odds ratios. It is suggested that anaemia during the second trimester was associated with preterm birth, but it does not account for the large ethnic differences in preterm birth. KW - anaemia KW - birth weight KW - ethnic groups KW - Pregnancy KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anemia KW - gestation KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911436313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. AU - Pearce, E. J. AU - Caspar, P. AU - Grzych, J. M. AU - Lewis, F. A. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1991/// VL - 173 IS - 1 SP - 159 EP - 166 SN - 0022-1007 AD - Pearce, E. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Rike, Bethesda, MD 20892, USA. N1 - Accession Number: 19910875550. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - Preliminary data showing enhanced interleukin-5 (IL-5) production by T cells from infected mice and interferon γ (IFN-γ) synthesis by cells from vaccinated animals, suggested differential CD4+ subset stimulation by the different parasite stimuli. To confirm this hypothesis, lymphocytes from vaccinated or S. mansoni infected animals were compared for their ability to produce IFN-γ and IL-2 (secreted by Th1 cells) as compared with IL-4 and IL-5 (characteristic Th2 cytokines). After stimulation with specific antigen or mitogen, T cells from vaccinated 6-8 week-old female C57BL/6 mice or prepatently infected animals responded primarily with Th1 lymphokines, whereas lymphocytes from patently infected mice instead produced Th2 cytokines. The Th2 response in infected animals was shown to be induced by schistosome eggs and directed largely against egg antigens, whereas the Th1 reactivity in vaccinated mice was triggered primarily by larval antigens. Th1 responses in mice carrying egg-producing infections were found to be profoundly downregulated. Moreover, the injection of eggs into vaccinated mice resulted in a reduction of antigen and mitogen-stimulated Th1 function accompanied by a coincident expression of Th2 responses. Together, the data suggest that coincident with the induction of Th2 responses, murine schistosome infection results in an inhibition of potentially protective Th1 function. This previously unrecognized downregulation of Th1 cytokine production may be an important immunological consequence of helminth infection related to host adaptation. KW - Cytokines KW - helminths KW - immune response KW - immunization KW - Interferon KW - Interleukins KW - Laboratory animals KW - Live vaccines KW - parasites KW - T lymphocytes KW - Vaccines KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - attenuated vaccines KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875550&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dengue virus premembrane and membrane proteins elicit a protective immune response. AU - Bray, M. AU - Lai ChingJuh JO - Virology (New York) JF - Virology (New York) Y1 - 1991/// VL - 185 IS - 1 SP - 505 EP - 508 SN - 0042-6822 AD - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950506368. Publication Type: Journal Article. Language: English. Number of References: 14 ref. N2 - Recombinant vaccinia viruses were expressed which express the premembrane (pre-M), membrane (M), or the cleaved, residual portion of pre-M (non-M) proteins of dengue 4 virus, or the pre-M, non-M, or envelope (E) proteins of dengue 2 virus, to evaluate their ability to induce protective immunity in mice. Cells infected with these recombinants make proteins of expected size. Mice immunized with recombinants expressing dengue 4 pre-M or M were protected against subsequent dengue 4 encephalitis challenge, but non-M was not protective. A recombinant which expressed dengue 2 E was partially protective against homotypic challenge, but dengue 2 pre-M was not protective. However, a recombinant which expressed both pre-M and E as a polyprotein gave solid protection, while the simultaneous administration of the 2 recombinants expressing pre-M and E gave a significant level of protection. Pre-M and M function as antigens eliciting a protective immune response, and the combination of pre-M plus E is more protective than E alone. KW - arboviruses KW - immunization KW - recombination KW - viral proteins KW - dengue 4 virus KW - dengue virus KW - mice KW - vaccinia virus KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - arthropod-borne viruses KW - genetic recombination KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506368&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High-performance liquid chromatography of lipids for the identification of human metabolic disease. AU - Markello, T. C. AU - Guo, J. AU - Gahl, W. A. JO - Analytical Biochemistry JF - Analytical Biochemistry Y1 - 1991/// VL - 198 IS - 2 SP - 368 EP - 374 SN - 0003-2697 AD - Markello, T. C.: Section on Human Biochemical Genetics, Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19931461206. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition N2 - A quantitative lipid analysis using ternary gradient high-performance liquid chromatography with evaporative light scattering detection is described. This technique was applied to extracts of cultured fibroblasts, cultured lymphocytes, and leukocytes and to liver and spleen biopsy specimens. Separation of nonpolar lipids, glycolipids, phospholipids, and sphingolipids was achieved in a single run. Detection did not depend on any specific chemical reactions, uv absorption, or fluorescence. Sensitivity is below 200 ng for individual lipids, and many individual lipid classes were detected in samples as small as 1 mg of total protein, the yield of a single flask of cultured skin fibroblasts. The characteristic stored lipids cholesterol ester and sphingomyelin were seen in excess in human fibroblast cultures from patients with Wolman's disease and Niemann-Pick disease, respectively. A biopsy spleen sample from a patient with Gaucher's disease had a large glucosyl-ceramide peak. It is concluded that this technique provides a tool for detecting lipids that accumulate in tissues of patients with currently unidentified metabolic storage disorders. KW - analytical methods KW - HPLC KW - Lipids KW - Metabolic disorders KW - tissues KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - high performance liquid chromatography KW - lipins KW - metabolic diseases KW - Techniques and Methodology (ZZ900) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461206&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ocular manifestations of AIDS. AU - Smet, M. D. de AU - Nussenblatt, R. B. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1991/// VL - 226 IS - 21 SP - 3019 EP - 3022 SN - 0098-7484 AD - Smet, M. D. de: National Eye Institute, National Institutes of Health, Building 10, Room 10N202, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879150. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology N2 - Of 3 described cases of ocular manifestations in AIDS, one was suffering from Toxoplasma gondii infection. The 8-year-old girl, from Maryland, USA, presented for a routine examination when she was noted to have a peripheral white retinal scar with a central area of retinal and choroidal atrophy and no hyperpigmentation. Her visual acuity was 6/12 (20/40); 4 months later, she returned with an active infiltrate at the edge of the scar. A diagnosis of ocular toxoplasmosis was made, and she was started on a combination of pyrimethamine, sulfadiazine sodium, and leucovorin calcium. Within a month the lesion resolved and became pigmented. Two months later, she returned with counting-fingers vision in her left eye and a fresh new lesion had developed under her macula. Again she was treated with anti-toxoplasmosis medication to which she responded rapidly. She was then kept on pyrimethamine and had no recurrences for the following 18 months. Her vision in the left eye was 6/9 (20/30). KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Case reports KW - Children KW - Eyes KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - Toxoplasmosis KW - Maryland KW - North America KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879150&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An immunogenic Onchocerca volvulus antigen: A specific and early marker of infection. AU - Lobos, E. AU - Weiss, N. AU - Karam, M. AU - Taylor, H. R. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Science (Washington) JF - Science (Washington) Y1 - 1991/// VL - 251 IS - 5001 SP - 1603 EP - 1605 SN - 0036-8075 AD - Lobos, E.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808674. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - A complementary DNA fragment coding for an Onchocerca volvulus antigen (OV-16) was cloned and expressed in the plasmid vector pCG808fx. The purified OV-16 was used in an ELISA to analyze the antibody responses of 41 onchocerciasis patients (aged 3 to 60 years), who had proven infections (microfilariae (mf) detected in the skin) and were residents of a region highly endemic for onchocerciasis in Mali. Sera from patients with other filarial infections were used to ascertain diagnostic specificity of OV-16. A sensitivity of 90% (37/41) and a specificity of 98% (1/57) for O. volvulus were obtained. The course of the humoral immune response to OV-16 in parallel with the onset of patency (first detection of mf in the skin) was monitored in 2 chimpanzees experimentally inoculated with infective O. volvulus larvae. In these chimpanzees, antibodies to OV-16 developed 3 months and 12 months before the appearance of skin mf. Because infection of children can be an important epidemiological indicator of ongoing transmission of O. volvulus, the antibody response to OV-16 was analyzed in 8 exposed but parasitologically negative children (aged 1 to 14) who were part of a 4-year longitudinal study in Mali. In 3 of the children, O. volvulus infection could be detection by the presence of antibodies to OV-16 during the prepatent period, 1 to 1.5 years before the appearance of mf in the skin. In 4 other children, significant levels of antibody were observed in the same year that mf appeared in the skin. In the 8th child, no clinical, parasitological, or serological evidence of infection was observed and the child was assumed to be truly uninfected. KW - Antigens KW - Children KW - clones KW - complementary DNA KW - ELISA KW - Filariids KW - Human diseases KW - Immune response KW - Immunodiagnosis KW - Africa KW - Mali KW - Man KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - ACP Countries KW - Francophone Africa KW - Africa KW - Least Developed Countries KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - antigenicity KW - cDNA KW - enzyme linked immunosorbent assay KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - Secernentea KW - serological diagnosis KW - Spirurida KW - Host Resistance and Immunity (HH600) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808674&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus. AU - Kaslow, D. C. AU - Isaacs, S. N. AU - Quakyi, I. A. AU - Gwadz, R. W. AU - Moss, B. AU - Keister, D. B. JO - Science (Washington) JF - Science (Washington) Y1 - 1991/// VL - 252 IS - 5010 SP - 1310 EP - 1313 SN - 0036-8075 AD - Kaslow, D. C.: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. N1 - Accession Number: 19910874410. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology N2 - The surface of mammalian cells infected with a recombinant vaccinia virus that expressed Pfs25 specifically bound transmission-blocking monoclonal antibodies. Furthermore, major histocompatibility complex-disparate congenic mouse strains immunized with recombinant Pfs25 elicited transmission-blocking antibodies, demonstrating that the capacity to develop transmission-blocking antibodies is not genetically restricted in mice. It is suggested that live recombinant viruses may provide an inexpensive, easily administered alternative to subunit vaccines prepared from purified recombinant proteins to block transmission of malaria in developing countries. KW - immunization KW - Laboratory animals KW - Malaria KW - parasites KW - recombinant vaccines KW - Apicomplexa KW - mice KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - vaccinia virus KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874410&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Centrally administered cholecystokinin suppresses feeding through a peripheral-type receptor mechanism. AU - Crawley, J. N. AU - Fiske, S. M. AU - Durieux, C. AU - Derrien, M. AU - Roques, B. P. JO - Journal of Pharmacology and Experimental Therapeutics JF - Journal of Pharmacology and Experimental Therapeutics Y1 - 1991/// VL - 257 IS - 3 SP - 1076 EP - 1080 SN - 0022-3565 AD - Crawley, J. N.: Unit on Behavioural Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bldg. 10, Room 2N214, Bethesda, MD 20892, USA. N1 - Accession Number: 19931467106. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Registry Number: 9011-97-6. Subject Subsets: Human Nutrition N2 - Agonists and antagonists selective for brain-type (cholecystokinin (CCK)-B) and peripheral-type (CCK-A) CCK receptor were used to localize site(s) of action at which CCK inhibits food consumption in male Sprague-Dawley rats weighing 250 g. BC 264, a highly selective CCK-B receptor agonist, did not decrease consumption of a palatable meal when given intraperitoneally or into the lateral ventricles of the brain (i.v.t.), whereas CCK decreased feeding when administered i.p. at the same doses. CCK decreased feeding when administered i.v.t. at a high dose, 5 µg. L-364,718, an antagonist selective for the CCK-A receptor, blocked completely the action of centrally administered CCK, whereas L-365,260, a selective CCK-B receptor antagonist, had no effect on the ability of centrally administered CCK to inhibit feeding. To estimate the quantity of i.v.t.-administered CCK which reached the periphery, a tracer of radiolabelled [³H]p-CCK8 ([³H]CCK octapeptide sulfate), combined with unlabelled pCCK8 (5 µg) was administered centrally. Thirty min after administration, intact radiolabelled pCCK8 was extracted from the plasma and estimated in the blood in nanomolar concentrations, exceeding the amounts of CCK octapeptide sulfate reported previously to be present in the plasma after a meal. Intraventricularly administered CCK thus seems to reduce feeding in the rat through a mechanism involving a CCK-A receptor subtype in the periphery. KW - Food intake KW - Pancreozymin KW - Man KW - Rats KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - cholecystokinin KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931467106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Muscle mitochondrial morphology, body composition, and energy expenditure in sedentary individuals. AU - Kirkwood, S. P. AU - Zurlo, F. AU - Larson, K. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1991/// VL - 260 IS - 1 pt 1 SP - E89 EP - E94 SN - 0002-9513 AD - Kirkwood, S. P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19931454425. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition N2 - The relationship between metabolic rate and muscle mitochondrial morphology and/or muscle respiration was investigated. 17 healthy volunteers, of both sexes, who did not undertake regular exercise, received a weight-maintaining diet for 3 days before commencement of metabolic studies. There was no relationship between mitochondrial morphology or muscle respiration and 24-h energy expenditure or basal metabolic rate. Central distribution of body fat showed a significant negative correlation with mitochondrial volume density (r = -0.58); central and peripheral mitochondrial volume density (r = -0.59 and -0.48, respectively); and muscle respiration (r = -0.59). It is concluded that central distribution of body fat is associated with (1) lower mitochondrial density and larger mitochondria in skeletal muscle; and (2) decreased oxidative capacity of muscle. KW - Body fat KW - distribution KW - metabolism KW - mitochondria KW - skeletal muscle KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931454425&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of endurance training on sedentary energy expenditure measured in a respiratory chamber. AU - Schulz, L. O. AU - Nyomba, B. L. AU - Alger, S. AU - Anderson, T. E. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1991/// VL - 260 IS - 2 Pt 1 SP - E257 EP - E261 SN - 0002-9513 AD - Schulz, L. O.: E. Ravussin, National Institutes of Health, 4212 N. 16th St., Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19921445448. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - The effect of endurance training on 24-h energy expenditure (EE), basal metabolic rate (BMR), sleeping metabolic rate (SMR), and the thermic effect of food (TEF) was assessed in a respiratory chamber where only spontaneous physical activity (SPA) was allowed. Results from 20 highly trained male endurance athletes (25±5 years old, 178±7 cm, 70±8 kg body weight, 64±7 kg fat-free mass) were compared with those of 43 untrained men who were matched for age (28±6 years old), height (175±5 cm), weight (73±13 kg), and fat-free mass (62±8 kg). Subjects were admitted to a metabolic ward, fed on a weight-maintenance diet with no physical activity for at least 2 days before measurements. No significant differences were found with respect to 24-h EE (2126±186 vs. 2154±245 kcal), BMR (1808±342 vs. 1709±329 kcal), SMR (1523±120 vs. 1555±188 kcal), or TEF (24.9±9.2 vs. 21.3±6/7% of ingested energy; these values included the energy cost of arousal) between trained and untrained subjects, respectively, before or after adjusting for differences in body composition. Neither the 24-h respiratory quotient nor the level of SPA differed between the 2 groups. No relation was found between maximal aerobic capacity and metabolic rate adjusted for differences in fat-free mass and fat mass. The results do not support an effect of fitness level on EE estimates under sedentary conditions. Therefore, although physical activity plays an important role in maintaining optimal health and body weight, its effect on energy output does not extend beyond the cost of the activity and recovery periods. KW - Athletes KW - calorimetry KW - energy exchange KW - physical fitness KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorimetric methods KW - keep fit KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy expenditure by doubly labeled water: validation in lean and obese subjects. AU - Ravussin, E. AU - Harper, I. T. AU - Rising, R. AU - Bogardus, C. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1991/// VL - 261 IS - 3, I SP - E402 EP - E409 SN - 0002-9513 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 19921451251. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - The doubly labelled water (²H218O) method to assess energy expenditure in free-living conditions has been successfully validated against gas exchange measurements in lean healthy volunteers in both sedentary conditions and during sustained heavy exercise. However, no data are available on obese subjects. Therefore, the ²H218O method was compared with indirect calorimetry (respiratory chamber) in 12 male subjects covering a wide range of body weight and composition (61-190 kg, 7-41% fat). Isotope pool sizes and elimination rates were calculated from 18O and ²H enrichments in baseline urine samples and in 7-h, 11.5-h, and daily post-dose urine samples using the multipoint slope/intercept method. Results were corrected for isotopic fractionation. Mean 7-day energy expenditure in the respiratory chamber varied from 1851 to 4105 kcal per day. The doubly labelled water method tended to underestimate energy expenditure (-2.5±5.8%, range -14 to +4%), with the larger underestimate observed in heavier and fatter subjects. The correlations of error in energy expenditure with body fat percentage and fat mass were -0.82 and -0.68, P<0.02, respectively. The underestimation in heavier subjects might be related to larger sequestration of deuterium during fat synthesis. In conclusion, the doubly labelled water method is a suitable and accurate method to measure energy expenditure in free-living conditions, but might provide a slighty underestimated figure in fatter subjects. KW - calorimetry KW - energy cost of activities KW - estimation KW - Obesity KW - tracer techniques KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorimetric methods KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921451251&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NIH technology assessment conference statement on bovine somatotropin. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1991/// VL - 265 IS - 11 SP - 1423 EP - 1425 SN - 0098-7484 AD - Office of Medical Applications of Research, Bidg 1, Room 260, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920455799. Publication Type: Journal Article. Corporate Author: USA, National Institutes of Health Language: English. Registry Number: 9002-72-6. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science N2 - In Dec. 1990 a Technology Assessment Panel was set up by the National Institutes of Health (Bethesda, Maryland, USA) to consider the scientific evidence relating to the safety of milk and meat for human consumption derived from recombinant bovine somatotropin (rGH)-treated cows, as well as the evidence relating to the effects of rGH on the health of cows. The panel considered the following subjects, which are discussed in this article: (1) methods of monitoring the role of milk in human nutrition and its safety for human consumption; (2) the nature of the comparative biology of human and bovine lactation, and milk composition; (3) the effect of rGH on milk yield of cows, and on the nutritional quality and hormonal content of their meat and milk; (4) the health effects on cows treated with rGH; (5) the health effects on humans who have consumed meat or milk from cows given rGH; (6) and whether further animal and human research is needed in association with the use of rGH. KW - animal welfare KW - Cows KW - milk KW - milk composition KW - milk yield KW - public health KW - Somatotropin KW - USA KW - cattle KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - animal rights KW - growth hormone KW - milk constituents KW - United States of America KW - Health Services (UU350) KW - Dairy Animals (LL110) KW - Milk and Dairy Produce (QQ010) KW - Food Composition and Quality (QQ500) KW - Animal Welfare (LL810) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920455799&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation. AU - Accili, D. AU - Mosthaf, L. AU - Ullrich, A. AU - Taylor, S. I. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1991/// VL - 266 IS - 1 SP - 434 EP - 439 SN - 0021-9258 AD - Accili, D.: Biochemistry and Molecular Pathophysiology Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921448251. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - A mutation which substitutes valine for phenylalanine382 in the α subunit of the insulin receptor was shown to impair the ability of insulin to activate receptor autophosphorylation in studies with NIH-3-T3 fibroblasts transfected with mutant or wild type human insulin receptor. Furthermore, the Val382 receptor has reduced activity to phosphorylate other peptide substrates in the presence of insulin. Nevertheless, when the Val382 mutant and wild-type receptors are mixed together, the wild-type human insulin receptor is able to phosphorylate the Val382 mutant receptor, thereby activating the tyrosine kinase activity of the mutant receptor. Thus, the conformation change caused by the Val382 mutation compromises the ability of the receptor to transmit a signal across the plasma membrane. Furthermore, the observations suggest that receptor phosphorylation by an intermolecular mechanism (i.e. transphosphorylation) may play a role in mediating the action of insulin upon the target cell. KW - Insulin KW - mutations KW - phosphorylation KW - receptors KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448251&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. AU - Lauer, M. S. AU - Anderson, K. M. AU - Kannel, W. B. AU - Levy, D. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1991/// VL - 266 IS - 2 SP - 231 EP - 236 SN - 0098-7484 AD - Lauer, M. S.: Framingham Heart Study of the National Heart, Lung and Blood Institute, 5 Thurber St., Framingham, MA 02215, USA. N1 - Accession Number: 19931456246. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - M-mode echocardiograms, which were adequate for estimation of left ventricular mass, were obtained in 3922 healthy participants (1256 men, 1666 women) in the Framingham Heart Study, Maryland, USA. Height and weight were measured and used to calculate body-mass index as an estimate of obesity. Body-mass index was strongly correlated with left ventricular mass. After adjusting for age and load pressure, body-mass index remained a strong independent predictor of left ventricular mass, left ventricular wall thickness and left ventricular internal dimension (P<0.01 for all). Body-mass index was associated with prevalence of echocardiographic left ventricular hypertrophy, particularly in subjects with a body mass index exceeding 30 kg/m². It is concluded that obesity, even of a mild to moderate degree, is significantly correlated with left ventricular mass and that the increase in left ventricular mass associated with obesity reflects increases in left ventricular wall thickness and left ventricular internal dimension. KW - heart KW - mass KW - Obesity KW - ventricles KW - Maryland KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456246&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The interaction of monomeric actin with two binding sites on Acanthamoeba actobindin. AU - Budd, M. R. AU - Lewis, M. S. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1991/// VL - 266 IS - 6 SP - 3820 EP - 3826 SN - 0021-9258 AD - Budd, M. R.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19910872325. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9064-37-3. Subject Subsets: Protozoology N2 - Actobindin from A. castellanii was previously shown to be an 88-residue polypeptide (MW 9761) with an internal tandem repeat of 33-34 amino acids. Sedimentation equilibrium experiments have confirmed this MW for native actobindin. Pyreneglyoxal-labelled actobindin from A. castellanii had a similar MW by sedimentation equilibrium analysis and bound to actin in a manner qualitatively similar to unmodified actobindin as determined by gel electrophoretic analysis of covalently cross-linked products. The stoichiometry of the actin-actobindin interaction was determined from the change in apparent MW of pyreneglyoxal-labelled actobindin in the presence of actin, as determined by scanning the ultracentrifuge cell at a wavelength that detected only the labelled protein. These data were consistent with the formation of a complex containing 2 actin and one actobindin molecules. The overall KDdescribing the binding of the first actin to either of the 2 sites on actobindin was 3.3 µM. The binding constant for the 2nd actin suggested either negative cooperativity or inequality of the 2 actin binding sites. Similar binding constants were obtained by analysis of the fluorescence enhancement that occurred when actobindin bound to actin labelled with either pyrene iodoacetamide or 4-(N-iodoacetoxyethyl-N-methyl)-7-nitrobenz-2-oxa-1,3-diazole. Cross-linking experiments with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide and N-hydroxysulfosuccinimide qualitatively agreed with predictions made from a 2-binding site model. Additionally, both the fluorescence and cross-linking experiments suggested that the interaction of the 2 actin molecules may contribute to the stability of the heterotrimeric complex. KW - actin KW - Biochemistry KW - parasites KW - proteins KW - Acanthamoeba castellanii KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - actobindin KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The discovery of creatinine assimilation in Cryptococcus neoformans, and subsequent work on the characterization of the two varieties of C. neoformans. AU - Kwon-Chung, K. J. JO - Zentralblatt für Bakteriologie JF - Zentralblatt für Bakteriologie Y1 - 1991/// VL - 275 IS - 3 SP - 390 EP - 393 SN - 0934-8840 AD - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911210471. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The discovery of creatinine assimilation in C. neoformans served as the foundation for biochemical, genetic, ecological, epidemiological and taxonomic studies on the 2 varieties of C. neoformans during a 15-yr period. The results of these investigations are summarized. It is concluded that the 2 varietal concept is now widely accepted and the arrival of the AIDS epidemic has promoted the recognition of the differences between the 2 varieties, especially in their epidemiology and ecology. Since the agent of cryptococcosis in AIDS patients almost always belongs to the var. neoformans even in geographical areas prevalent for var. gattii, it is suggested that it is now important to study the possible differences in the pathogenesis of the 2 varieties. KW - taxonomy KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus neoformans KW - Cryptococcus neoformans var. gattii KW - fungus KW - systematics KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210471&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials. AU - Teo, K. K. AU - Yusuf, S. AU - Collins, R. AU - Held, P. H. AU - Peto, R. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1991/// VL - 303 IS - 6816 SP - 1499 EP - 1503 SN - 0959-8138 AD - Teo, K. K.: S. Yusuf, Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19921444683. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 7439-95-4. Subject Subsets: Human Nutrition N2 - To investigate the effect of intravenous magnesium on mortality in suspected acute myocardial infarction, a systematic overview of 7 randomised trials in which 1301 patients were allocated to receive either intravenous Mg or otherwise similar treatment without Mg in coronary care units of several hospitals was undertaken. Considering the 7 trials collectively there were 25 (3.8%) deaths among 657 patients allocated to receive Mg and 53 (8.3%) deaths among 644 patients allocated control, generally during hospital follow-up. This represents a 55% reduction in the odds of death (P<0.001) with 95% confidence intervals ranging from about one-third to about two-thirds. 70 of 648 patients allocated Mg compared with 109 of 641 controls had serious ventricular arrhythmias, suggesting that Mg reduces the incidence, though the definition varied among trials. Other adverse effects were rare in the limited number of patients for whom data were available. It is concluded that despite the limited number of patients randomised, this overview suggests that intravenous Mg therapy may reduce mortality in patients with acute myocardial infarction. Further large scale trials to confirm (or refute) these findings are desirable. KW - magnesium KW - mortality KW - Myocardial infarction KW - parenteral feeding KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - death rate KW - heart attack KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444683&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oxoaporphine alkaloids: conversion of lysicamine into liriodendronine and its 2-O-methyl ether, and antifungal activity. AU - Pabuccuoglu, V. AU - Rozwadowska, M. D. AU - Brossi, A. AU - Clark, A. AU - Hufford, C. D. AU - George, C. AU - Flippen-Anderson, J. L. JO - Archiv der Pharmazie (Weinheim) JF - Archiv der Pharmazie (Weinheim) Y1 - 1991/// VL - 324 IS - 1 SP - 29 EP - 33 SN - 0365-6233 AD - Pabuccuoglu, V.: Medicinal Chemistry Section, LAC, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19911209661. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Oxoaporphine alkaloids including lysicamine, liriodendronine and its 2-O-methyl ether were synthesized and tested for antifungal activity against Candida albicans. KW - antifungal agents KW - antifungal properties KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - Oxoaporphine alkaloids KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Analysis of aqueous humor in ocular toxoplasmosis. AU - Brézin, A. P. AU - Eqwuagu, C. E. AU - Silveira, C. AU - Thulliez, P. AU - Martins, M. C. AU - Mahdi, R. M. AU - Belfort, R., Jr. AU - Nussenblatt, R. B. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1991/// VL - 324 IS - 10 SP - 699 EP - 699 SN - 0028-4793 AD - Brézin, A. P.: National Eye Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19920884448. Publication Type: Correspondence. Language: English. Number of References: 6 ref. Subject Subsets: Protozoology N2 - The correspondents report the use of the polymerase chain reaction to identify Toxoplasma gondii in aqueous humor in patients with presumed ocular toxoplasmosis. This method is of particular use when diagnosis is needed in cases of atypical retinitis or when the fundus is masked by vitreal inflammation. Samples of aqueous humor from 17 Brazilian patients with clinical presentations consistent with ocular toxoplasmosis were examined. All patients were seropositive for toxoplasmosis. Using the polymerase chain reaction T. gondii DNA was detected in the aqueous humor of 3 patients during 2 independent amplifications of the B1 gene fragment. The amplified product was detected by Southern blot analysis with an oligonucleotide internal to the amplified fragment. This is believed to be the first method reported that can identify the parasite in human aqueous humor. KW - diagnosis KW - eyes KW - human diseases KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - Brazil KW - North America KW - South America KW - USA KW - apicomplexa KW - man KW - protozoa KW - sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - aqueous humor KW - biochemical genetics KW - PCR KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920884448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of circulating Candida enolase by immunoassay in patients with cancer and invasive candidiasis. AU - Walsh, T. J. AU - Hathorn, J. W. AU - Sobel, J. D. AU - Merz, W. G. AU - Sanchez, V. AU - Maret, S. M. AU - Buckley, H. R. AU - Pfaller, M. A. AU - Schaufele, R. AU - Sliva, C. AU - Navarro, E. AU - Lecciones, J. AU - Chandrasekar, P. AU - Lee, J. AU - Pizzo, P. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1991/// VL - 324 IS - 15 SP - 1026 EP - 1031 SN - 0028-4793 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19911209112. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 170 patients at high risk for invasive candidosis were tested for Candida enolase antigenaemia. All the patients had cancer and neutropenia. Antigen was detected using a double-sandwich liposomal immunoassay for Candida enolase in serially collected serum samples. Invasive candidosis was proved by finding Candida spp. in deep nonmucosal tissue, blood cultures or both. Among 24 patients with proved invasive candidosis (caused by C. albicans, C. tropicalis, C. parapsilosis and Candida sp.), 149 serum samples were tested for enolase antigenaemia; 80 were positive and 69 negative (sensitivity per sample, 54%). Multiple sampling improved the detection of antigenaemia, which was found in 11 of 13 proved cases of deep tissue infection (85%) and in 7 of 11 proved cases of fungaemia (64%). Specificity was 96% as measured against control groups including patients with mucosal colonization, bacteraemia and other deep mycoses. Antigenaemia was detected in the absence of fungaemia in 5 cases of deep tissue candidosis, but was not detected in 6 cases of fungaemia alone. It is concluded that Candida enolase antigenaemia is a novel marker for invasive candidosis and that it may be a useful indicator of deep infection in patients with cancer and neutropenia and may complement the diagnostic usefulness of blood cultures. KW - antigens KW - hosts KW - immunoassay KW - immunological techniques KW - immunology KW - infections KW - neoplasms KW - predisposition KW - USA KW - Candida KW - Candida albicans KW - Candida parapsilosis KW - Candida tropicalis KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - cancers KW - fungus KW - Hyphomycetes KW - immunogens KW - serological techniques KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911209112&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. AU - Falloon, J. AU - Kovacs, J. AU - Hughes, W. AU - O'Neill, D. AU - Polis, M. AU - Davey, R. T., Jr. AU - Rogers, M. AU - Lafon, S. AU - Feuerstein, I. AU - Lancaster, D. AU - Land, M. AU - Tuazon, C. AU - Dohn, M. AU - Greenberg, S. AU - Lane, H. C. AU - Masur, H. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1991/// VL - 325 IS - 22 SP - 1534 EP - 1538 SN - 0028-4793 AD - Falloon, J.: Bldg. 10, Rm. 7D43, Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920876624. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Public Health N2 - An open-label trial of 566C80 (a hydroxynaphthoquinone) in 34 adults from the USA with AIDS and untreated P. carinii pneumonia (PCP). All the patients had a partial pressure of arterial oxygen of at least 60 mm Hg while breathing room air. They were enrolled sequentially in 3 cohorts taking 566C80 at different dosages, all administered orally: 750 mg 3 times daily for 5 days, then twice daily for 16 days; 750 mg 3 times daily for 21 days; and 750 mg 4 times daily for 21 days. All 34 patients survived, and 27 (79%) were successfully treated with 566C80 alone. The mean partial pressure of oxygen in 33 patients was 78 mm Hg at entry and 93 mm Hg after the course of 566C80. In 5 patients (15%) the drug was discontinued because of lack of response. In 4 patients (12%), the drug was discontinued because of toxicity (fever and rash in 2 patients each). In 2 of these, treatment was considered to have succeeded because 566C80 was not discontinued because of toxicity until after day 14. Five of the successfully treated patients had rashes that resolved despite continued therapy. In 9 patients, serum alanine aminotransferase levels rose above 100 U/litre. During the first 3 months after the completion of therapy, PCP recurred in 4 of the 27 successfully treated patients, and another 3 patients had recurrences between month 3 and month 6 of follow-up. The mean (±SEM) steady-state plasma levels of 566C80 were similar in the 3 cohorts: 16.3±2.10, 20.4±2.48, and 18.9±3.08 µg/ml in the patients taking the drug twice daily, 3 times daily, and 4 times daily, respectively. From these preliminary data, the investigational compound 566C80 is concluded to be a safe, effective, and well-tolerated therapy for PCP of mild-to-moderate severity in patients with AIDS.<new para>ADDITIONAL ABSTRACT:<new para>The hydroxynaphthoquinone 566C80 is active against Pneumocystis carinii in vitro and in animal models. Initial studies in humans indicate that it is safe and has adequate bioavailability after oral administration. In an open-label trial of 566C80 34 adults with AIDS and untreated Pneumocystis pneumonia were enrolled sequentially in 3 cohorts taking 566C80 at different dosages, all administered orally: 750 mg 3 times daily for 5 days, then twice daily for 16 days; 750 mg 3 times daily for 21 days; and 750 mg 4 times daily for 21 days. All 34 patients survived, and 27 (79%) were successfully treated with 566C80 alone. In 5 patients (15%) the drug was discontinued because of lack of response. In 4 patients (12%) the drug was discontinued because of toxicity (fever and rash in 2 patients each). In 2 of these, treatment was considered to have succeeded because 566C80 was not discontinued because of toxicity until after day 14. Five of the successfully treated patients had rashes that resolved despite continued therapy. In 9 patients, serum alanine aminotransferase activities rose above 100 U/l. During the first 3 months after the completion of therapy, Pneumocystis pneumonia recurred in 4 of the 27 successfully treated patients, and another 3 patients had recurrences between month 3 and month 6 of follow-up. The mean (± SEM) steady-state plasma levels of 566C80 were similar in the 3 cohorts: 16.3 ± 2.10, 20.4 ± 2.48, and 18.9 ± 3.08 µg per milliliter in the patients taking the drug twice daily, 3 times daily, and 4 times daily, respectively.D.W. FitzSimons KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - adverse effects KW - Antiprotozoal agents KW - clinical aspects KW - clinical trials KW - drug therapy KW - Efficacy KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Novel antiprotozoal agents KW - Opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - pneumocystosis KW - pneumonia KW - Treatment KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - 566C80 KW - adverse reactions KW - AIDS KW - chemotherapy KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - Hydroxynaphthoquinones KW - Hydroxynapthoquinone KW - Opportunstic infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876624&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine. AU - Simanjuntak, C. H. AU - Paleologo, F. P. AU - Punjabi, N. H. AU - Darmowigoto, R. AU - Soeprawoto AU - Totosudirjo, H. AU - Haryanto, P. AU - Suprijanto, E. AU - Witham, N. D. AU - Hoffman, S. L. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1991/// VL - 338 IS - 8774 SP - 1055 EP - 1059 SN - 0140-6736 AD - Simanjuntak, C. H.: Center for Infectious Diseases Research, National Institutes of Health Research and Development, Ministry of Health, Jalan Percetakan Negara 29, Jakarta 10560, Indonesia. N1 - Accession Number: 19972007292. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - When tested under conditions of moderate transmission of typhoid fever, a liquid formulation of the oral typhoid fever vaccine Ty21a had a protective efficacy of 96% in Egypt, and an enteric coated capsule formulation had an efficacy of 67% in Chile. The two formulations were compared under conditions of intense transmission of typhoid fever in Indonesia in a randomized, double-blind trial in 1986. 20 543 subjects (age range 3-44 years) received either 3 doses of enteric coated capsules containing placebo or live Ty21a, or 3 doses of lyophilised placebo or live Ty21a reconstituted with phosphate buffer. During 30 months of follow up (October 1986 to March 1989),the rate of blood-culture-positive typhoid fever among controls was 810/100 000 per year.Rates of typhoid fever were 379/100 000 per year for subjects who received the liquid formulation of vaccine and 468/100 000 per year for subjects who received enteric coated capsules. The protective efficacies of the liquid and enteric coated formulations were 53% and 42% respectively. Neither formulation protected against infections with Salmonella paratyphi A. No major side-effects were noted, but the overall incidence of side-effects was greater in the vaccine groups. Under conditions of intense transmission, Ty21a protected against typhoid fever; however, because Ty21a will not protect all individuals, there is a need for additional approaches to prevent the disease. KW - disease transmission KW - efficacy KW - formulations KW - human diseases KW - immunization KW - typhoid KW - vaccines KW - Asia KW - Indonesia KW - man KW - salmonella typhi KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - bacterium KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007292&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exposure to certain pesticides may pose real carcinogenic risk. AU - Huff, J. E. AU - Haseman, J. K. JO - Pesticides News JF - Pesticides News Y1 - 1991/// IS - 12 SP - 7 EP - 10 AD - Huff, J. E.: Division of Biometry and Risk Assessment, US National Institute of Environmental Health Sciences, USA. N1 - Accession Number: 19940800101. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology N2 - Based on experience in designing, conducting and evaluating approximately 200 rodent carcinogenicity studies on a variety of chemicals, including pesticides, the authors suggest that there is considerable evidence that exposure to certain pesticides may present real carcinogenic hazard to humans. In the absence of epidemiological data, current rodent bioassays provide guidance to regulators about the need to regulate human exposure to certain pesticides. KW - animal experiments KW - carcinogenesis KW - exposure KW - neoplasms KW - pesticides KW - regulations KW - toxicity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - animal research KW - cancers KW - pesticide legislation KW - rules KW - Laws and Regulations (DD500) KW - Pesticides and Drugs (General) (HH400) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800101&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Endogenous nitrosamines and liver fluke as risk factors for cholangiocarcinoma in Thailand. AU - Srivatanakul, P. AU - Ohshima, H. AU - Khlat, M. AU - Parkin, M. AU - Sukarayodhin, S. AU - Brouet, I. AU - Bartsch, H. A2 - O'Neill, I. K. A2 - Chen, J. A2 - Bartsch, H. T2 - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins. JO - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins. JF - IARC Publication No. 105: Relevance to human cancer of n-nitroso compounds, tobacco and mycotoxins. Y1 - 1991/// SP - 88 EP - 95 CY - Lyon: International Agency for Research on Cancer SN - 9283221052 AD - Srivatanakul, P.: National Cancer Institute of Thailand, Bangkok, Thailand. N1 - Accession Number: 19940803763. Publication Type: Miscellaneous. Corporate Author: International Agency for Research on Cancer Language: English. Number of References: 15 ref. Subject Subsets: Helminthology N2 - An association between cholangiocarcinoma (CCA) and the liver fluke Opisthorchis viverrini (OV) in north-east Thailand has been reported. 12-hour overnight urine samples (after dosing with 500 mg proline and 200 mg ascorbic acid or 500 mg proline alone) from about 100 inhabitants of 5 contrasting incidence areas for CCA and hepatocellular carcinoma were analyzed. It was shown that the incidences of CCA and hepatocellular carcinoma did not correlate with the amount of nitrosamino acids, endogenous nitrosation potential or nitrate level in urine. However, subjects who were positive for OV antibody excreted significantly more N-nitrosamine (NPRO) after proline ingestion than those who were negative. After ingestion of ascorbic acid, the NPRO levels in the positive subjects were significantly reduced, suggesting that endogenous nitrosation of proline was inhibited. These results indicate that the interaction between chemical carcinogens, especially nitrosamines, and OV infestation may play a role in the pathogenesis of CCA in Thailand. KW - bile ducts KW - carcinoma KW - helminths KW - human diseases KW - liver diseases KW - neoplasms KW - opisthorchiasis KW - parasites KW - pathology KW - Asia KW - Thailand KW - Digenea KW - man KW - Opisthorchiidae KW - Opisthorchis viverrini KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Digenea KW - Opisthorchis KW - Opisthorchiidae KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - cancers KW - opisthorchiosis KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803763&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fatty acid composition of present day diets. AU - Ernst, N. D. A2 - Nelson, G. J. T2 - Health effects of dietary fatty acids. JO - Health effects of dietary fatty acids. JF - Health effects of dietary fatty acids. Y1 - 1991/// SP - 1 EP - 11 CY - Champaign; USA PB - American Oil Chemists Society SN - 0935315314 AD - Ernst, N. D.: National Heart, Lung and Blood Institute, National Institutes of Health, 7550 Wisconsin Avenue, Room 204, Bethesda, MD 20892, USA. N1 - Accession Number: 19931459200. Publication Type: Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition N2 - Trends in fat consumption in the USA including the contribution of foods and food groups to fat intake and the fatty acid composition of US diets are reviewed. KW - composition KW - Diet KW - Diet studies KW - Fat consumption KW - fatty acids KW - reviews KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Health effects of dietary fatty acids KW - United States of America KW - Food Composition and Quality (QQ500) KW - Other Produce (QQ070) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459200&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Role of dengue virus membrane protein in resistance. AU - Bray, M. AU - Lai ChingJuh A2 - Chanock, R.M. A2 - Ginsberg, H.S. A2 - Brown, F. A2 - Lerner, R.A. T2 - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. JO - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. JF - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. Y1 - 1991/// SP - 245 EP - 249 CY - Plainview, NY; USA PB - Cold Spring Harbor Laboratory SN - 0879693673 AD - Bray, M.: Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950507452. Publication Type: Miscellaneous. Language: English. Number of References: 4 ref. N2 - Vaccinia recombinants containing cDNA encoding dengue virus pre-M, M and non-M proteins expressed apparently authentic proteins. Mice immunized with recombinants expressing D4 pre-M or the M protein, which forms part of the dengue virion, were protected against subsequent dengue virus challenge. A recombinant expressing non-M, the portion of pre-M discarded during virion maturation, gave no protection. The dengue M protein constitutes a protective antigen of dengue virus that should be taken into consideration in the development of dengue virus vaccines. KW - arboviruses KW - immunization KW - laboratory animals KW - membranes KW - recombinant DNA KW - vaccines KW - viral proteins KW - dengue virus KW - mice KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507452&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Carboxy-terminally truncated dengue virus envelope glycoprotein expressed on the cell surface exhibit increased immunogenicity in mice. AU - Men RuHe AU - Bray, M. AU - Lai ChingJuh A2 - Chanock, R.M. A2 - Ginsberg, H.S. A2 - Brown, F. A2 - Lerner, R.A. T2 - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. JO - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. JF - Vaccines 91. Modern approaches to new vaccines including prevention of AIDS. Y1 - 1991/// SP - 251 EP - 257 CY - Plainview, NY; USA PB - Cold Spring Harbor Laboratory SN - 0879693673 AD - Men RuHe: Molecular Virology Biology Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950507453. Publication Type: Miscellaneous. Language: English. Number of References: 5 ref. N2 - The antigenic structure of dengue envelope (E) glycoprotein was investigated with the goal of increasing its immunogenicity. Recombinant vaccinia viruses were constructed that contained dengue cDNA coding for carboxy-terminally truncated E that ranged in length from 9% to 99% of the amino-terminal sequence. Overall antigenicity of the E products was analysed by radioimmunoprecipitation using dengue HMAF or an E peptide antiserum. Truncated E that was 79% or less in length did not bind HMAF efficiently, whereas E constructs >79% were able to bind HMAF with high efficiency. An R residue at position 392 in the dengue-type-4 E sequence immediately following the 79% E carboxyl terminus appeared to be critical for proper conformation and antigenic structure required for efficient binding by HMAF. Truncated E ranging from 59% to approximately 80% in length was secreted extracellularly, whereas larger E constructs were retained intracellularly. Only constructs that contained 79% E plus 1 to 5 amino acids of the downstream RKGSS sequence were expressed in high concentration on the surface of recombinant-virus-infected cells, presumably being inserted into the plasma membrane by a carboxy-terminal membrane anchor. Studies in mice indicated that only truncated E constructs that were recognized efficiently by HMAF induced a high level of resistance to dengue virus encephalitis. Among the truncated E constructs that were able to bind HMAF efficiently, only 79% E-RKG was expressed in high concentration on the cell surface. Significantly, only 79% E-RKG induced an appreciable E antibody response, suggesting that cell-surface expression was responsible for its enhanced immunogenicity. Results from plaque-reduction and neutralization tests and passive immunized studies in mice involving serum transfer indicated that serum antibodies to E played a major role in the complete or nearly complete resistance induced by immunization. Finally, dengue-type-2 virus E similarly truncated to 79% E-RKG also exhibited increased protective immunity against homotypic dengue challenge in mice, suggesting that it may be possible to extend this strategy to construct E glycoproteins of other flaviviruses that are more immunogenic and protective. KW - arboviruses KW - glycoproteins KW - immunization KW - laboratory animals KW - vaccines KW - viral proteins KW - dengue virus KW - mice KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507453&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Food allergy: adverse reactions to foods and food additives. A2 - Metcalfe, D. D. A2 - Sampson, H. A. A2 - Simon, R. A. T2 - Food allergy: adverse reactions to foods and food additives. Y1 - 1991/// CY - Oxford; UK PB - Blackwell Scientific Publications Ltd SN - 0865420947 AD - Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19941404458. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition N2 - This 29-chapter multiauthor book is divided into a review of food allergy, adverse reactions to food additives and contemporary topics. Aimed at clinicians, nutritionists and scientists interested in food reactions, it covers paediatric and adult reactions to foods. Each chapter reviews current knowledge on a specific topic and overall the text presents a state-of-the-art of research in food allergies. KW - antigens KW - food additives KW - food allergies KW - foods KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - food hypersensitivity KW - immunogens KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404458&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Pneumocystis carinii pneumonia (PCP). AU - Lipschik, G. Y. AU - Masur, H. A2 - Sun, T. T2 - Progress in clinical parasitology; volume 2. Y1 - 1991/// CY - Philadelphia, PA; USA PB - Field & Wood Inc., Medical Publications SN - 0938607367 AD - Lipschik, G. Y.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19910874431. Publication Type: Book chapter. Language: English. Number of References: 294 ref. Subject Subsets: Protozoology N2 - A review of P. carinii pneumonia, and its implications in man, with particular reference to AIDS patients, is given. The clinical manifestations, histopathology, diagnosis, therapy, prognostic factors, residual effects, and prophylaxis are examined in detail. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Lungs KW - Opportunistic infections KW - parasites KW - Pneumonia KW - reviews KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - fungus KW - human immunodeficiency virus KW - progress in clinical parasitology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910874431&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet. AU - Zheng, W. AU - Blot, W. J. AU - Shu, X. O. AU - Diamond, E. L. AU - Gao, Y. T. AU - Ji, B. T. AU - Fraumeni, J. F., Jr. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1992/// VL - 1 IS - 6 SP - 441 EP - 441 SN - 1055-9965 AD - Zheng, W.: National Cancer Institute, Executive Plaza North, Room 431, Bethesda, MD 20392, USA. N1 - Accession Number: 19941401594. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition N2 - A population-based case-control study of oral and pharyngeal cancer was conducted in Shanghai, China, from 1988 to 1990, in which 204 (115 male, 89 female) incident cases and 414 (269 male, 145 female) controls were interviewed. Cigarette smoking and alcohol consumption, as well as occupational exposure to asbestos and to petroleum products and the use of kerosene stoves in cooking, were associated with increased risk of oral and pharyngeal cancer. In addition, more cases than controls reported having chronic oral diseases and false teeth. Dietary intakes of 42 major foods and selected salt-preserved or deep-fried foods during the past 10 years, ignoring any recent changes, were measured by a structured quantitative food questionnaire. The findings confirmed that dietary factors play an important role in the development of oral and pharyngeal cancer. High consumption of salt-preserved meat and fish was associated with an excess risk in this respect. KW - alcoholic beverages KW - carcinoma KW - diet KW - larynx KW - mouth KW - risk KW - tobacco smoking KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - People's Republic of China KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401594&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Height and weight at various ages and risk of breast cancer. AU - Brinton, L. A. AU - Swanson, C. A. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1992/// VL - 2 IS - 5 SP - 597 EP - 597 SN - 1047-2797 AD - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951404263. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - Risk in relation to lifetime changes in body size was studied in 1529 patients with mammary neoplasms and 1901 controls. Tallness, regardless of when achieved, was associated with increased risk of breast cancer diagnosed at young (before 50 years old) and older ages, with adult height of 68 in or more increasing risk by nearly 50 to 80% compared with heights less than 62 in. Association of risk with weight was less clear. Women who described themselves as heavier than average at 8 to 9 or 16 years old were at reduced risk, particularly for older-onset breast cancer. Greater body mass indices based on reported weight during early adulthood were also associated with reduced risk. Measures of body mass beyond 20 years old were less strongly related to risk. These inconsistent patterns seemed to be explained by an effect on risk of weight gain later in life, which was related to reduced risks for young-onset cancer and increased risks for later disease. Effect of weight change for early-onset cancer was not restricted to neoplasms in situ and could therefore not be attributed to detection bias. The direct relation of body mass change with older-onset disease was restricted to invasive neoplasms, consistent with observations of poor breast cancer prognosis among obese women. KW - age KW - height KW - mammary gland neoplasms KW - risk KW - weight KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404263&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lipids and risk of coronary heart disease: The Framingham Study. AU - Castelli, W. P. AU - Anderson, K. AU - Wilson, P. W. F. AU - Levy, D. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1992/// VL - 2 IS - 1/2 SP - 23 EP - 28 SN - 1047-2797 AD - Castelli, W. P.: Framington Heart Study, National Heart Lung and Blood Institute, 5 Thurber Street, Framingham, MA 01701, USA. N1 - Accession Number: 19941400573. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition N2 - Data from the Framingham Study (Massachusetts, USA) was used to study the risk attributable to total cholesterol value in old age. The population used included 922 men and 1295 women 50 to 79 years old who were free of cardiovascular disease when lipoprotein fractions were estimated between 1968 and 1973. Total cholesterol value was significantly related to risk of heart disease, adjusted for other risk factors in women 50 to 79 years old and in men 50 to 44 years old (P<0.001). Prediction of risk was improved by the estimation of low-density lipoprotein cholesterol and high-density lipoprotein (HDL) cholesterol. Triacylglycerols were independently related in women at all ages but were not significant in multivariate studies in men. Total cholesterol:HDL cholesterol ratio was a strong predictor at all ages in women and was the only lipid predictor independently related to heart disease in men 65 to 80 years old. Absolute rates of disease increased with age. KW - blood lipids KW - heart diseases KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400573&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cholesterol as a risk factor for coronary heart disease in elderly men. The Baltimore Longitudinal Study of Aging. AU - Sorkin, J. D. AU - Andres, R. AU - Muller, D. C. AU - Baldwin, H. L. AU - Fleg, J. L. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1992/// VL - 2 IS - 1/2 SP - 59 EP - 67 SN - 1047-2797 AD - Sorkin, J. D.: Gerontology Research Center, National Institute on Aging, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19941400578. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The relation of cholesterol to heart disease (angina pectoris, myocardial infarction and sudden coronary death) was studied in 1052 men who were participants in the Baltimore (Maryland, USA) Longitudinal Study on Aging (a study of healthy, highly educated, middle class adults begun in 1958). The men were grouped according to age: 29 to 64 years (801), 65 to 74 years (357) and 75 to 97 years (250). In all 3 groups, cholesterol was a significant risk factor for heart disease. In the oldest group the relation between cholesterol and risk was linear (P=0.003); in the younger groups it was exponential. KW - blood KW - cholesterol KW - heart diseases KW - old age KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400578&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cholesterol, coronary heart disease, and total mortality in middle-aged and elderly men and women in Tecumseh. AU - Higgins, M. AU - Keller, J. B. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1992/// VL - 2 IS - 1/2 SP - 69 EP - 76 SN - 1047-2797 AD - Higgins, M.: National Heart, Lung and Blood Institute, Federal Building, Room 2C08, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19941400579. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Relations between serum cholesterol and heart disease were studied in men and women 45 to 92 years old initially free from heart disease living in Tecumseh, Michigan, USA. Recruitment continued through 3 cycles of examinations during 10 years, beginning in 1959. Follow-up for mortality ended in 1986-87. Age-adjusted relative risks for death from heart disease for cholesterol values of 5.2 to 6.2 and greater than 6.2 mmol/litre, compared with values less than 5.2 mmol/litre for men 45 to 64 years old, were 1.2 and 1.7; for older men they were 1.0 and 1.8. Comparable relative risks for death from heart disease by cholesterol value were 0.7 and 1.4 for women 45 to 64 years old and 0.8 and 0.7 for older women. Coefficients for cholesterol were significant for fatal heart disease in men under and in those 65 years and older when age, systolic blood pressure, body mass index, cigarette smoking status and glucose intolerance were controlled in proportional hazards models. Cholesterol was a significant predictor of fatal heart disease plus non-fatal infarction in middle-aged but not elderly women. Relative risks for total mortality were lowest for middle-aged men and women with cholesterol 5.2 to 6.2 mmol/litre. KW - age KW - blood KW - cholesterol KW - heart diseases KW - mortality KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - death rate KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400579&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cholesterol and heart disease in older persons and women. Review of an NHLBI workshop. AU - Manolio, T. A. AU - Pearson, T. A. AU - Wenger, N. K. AU - Barrett-Connor, E. AU - Payne, G. H. AU - Harlan, W. R. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1992/// VL - 2 IS - 1/2 SP - 161 EP - 176 SN - 1047-2797 AD - Manolio, T. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Federal Building, Room 212-A, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19941400592. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Papers on the value of serum total cholesterol estimation in the prediction of coronary heart disease in older persons and women at a recent US National Heart, Lung and Blood Institute workshop are reviewed. KW - blood KW - cholesterol KW - heart diseases KW - prediction KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - coronary diseases KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400592&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The World Health Organization research programme on aging. AU - Litvak, J. JO - Age & Nutrition JF - Age & Nutrition Y1 - 1992/// VL - 3 IS - 1 SP - 84 EP - 86 SN - 1158-0259 AD - Litvak, J.: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951404286. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Language of Summary: French. Number of References: 3 ref. Subject Subsets: Human Nutrition N2 - The WHO research programme on aging was set up in 1987 on the recommendation of the Advisory Committee on Health Research. The 4 initial priority areas are: research on factors responsible for healthy aging; dementias associated with aging; aging of the immune system; changes associated with nutrition, particularly osteoporosis. One of the characteristics of the research is the international approach, with comparison of results from different countries. Such comparative studies have great potential in research on risk factors in disease and disability as well as identification of protective factors leading to healthy aging. KW - nutrition research KW - old age KW - WHO KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - International meeting on nutrition in old age KW - World Health Organization KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404286&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cohort study of tobacco use, diet, occupation, and lung cancer mortality. AU - Chow, W. H. AU - Schuman, L. M. AU - McLaughlin, J. K. AU - Bjelke, E. AU - Gridley, G. AU - Wacholder, S. AU - Chien, H. T. C. AU - Blot, W. J. JO - Cancer Causes and Control JF - Cancer Causes and Control Y1 - 1992/// VL - 3 IS - 3 SP - 247 EP - 254 AD - Chow, W. H.: National Cancer Institute, 6130 Executive Blvd, EPN Room 407, Rockville, MD 20892, USA. N1 - Accession Number: 19931455874. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 50-81-7, 68-26-8. Subject Subsets: Human Nutrition N2 - In 1966, a cohort of 17 818 white males aged 35 or over, who were policy-holders with the Lutheran Brotherhood Insurance Society, USA, completed a questionnaire on tobacco use, diet and demographic characteristics. During the 20 years of follow-up, 219 lung cancer deaths occurred. Besides the strong relation with cigarette smoking, an effect on lung cancer risk was observed among current users of cigars or pipes who were non-smokers of cigarettes (relative risk (RR) = 3.5, 95% confidence interval (CI) = 1.0 to 12.6) or who were past/occasional users of cigarettes (RR = 2.7, CI = 1.4 to 5.3). In addition, elevated risks (from 1.5 to 2.6) of lung cancer were found among craftsmen and labourers, with the highest risks among subjects who worked in the mining or manufacturing industry. No association between current (as to 1966) use of beer or hard liquor and lung cancer was observed, although past users were at elevated risk. An inverse association between lung cancer and intake of fruits was observed, and risks of lung cancer were lower among persons in the highest dietary intake quintiles of vitamins A and C. Except for oranges, however, none of the inverse associations with fruits or dietary nutrients had significant trends. The findings from this cohort study add to the evidence of an adverse effect of cigar/pipe smoking and possible protective effect of dietary factors on lung cancer risk. KW - Ascorbic acid KW - carcinoma KW - diet KW - lungs KW - Men KW - occupations KW - Retinol KW - risk KW - tobacco smoking KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931455874&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality among laboratory workers employed at the U.S. Department of Agriculture. AU - Dosemeci, M. AU - Alavanja, M. AU - Vetter, R. AU - Eaton, B. AU - Blair, A. JO - Epidemiology JF - Epidemiology Y1 - 1992/// VL - 3 IS - 3 SP - 258 EP - 262 SN - 1044-3983 AD - Dosemeci, M.: Occupational Studies Section, Epidemiology and Biostatistics Program, National Cancer Institute, Building EPN, Room 418, Rockville, MD 20892, USA. N1 - Accession Number: 19932020078. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - [The authors] evaluated the mortality of 835 white male and 36 female laboratory workers employed by the U.S. Department of Agriculture who died between January 1, 1970, and December 31, 1979. For males, the mortality odds ratio for all cancers was 1.0 (95% confidence interval = 0.8-1.2). Colon cancer, lymphosarcoma and reticulosarcoma, nonmalignant diseases of the blood and blood-forming organs, and suicide showed elevated mortality odds ratios. Only colon cancer showed an association with duration of employment as a laboratory worker. In an accompanying case-control study, the risk of colon cancer rose to 3.2 among those who had 20 or more years of employment as a laboratory worker. Among females, breast cancer was elevated (mortality odds ratio = 5.3; 95% confidence interval = 2.8-10.1). AS KW - laboratories KW - Laboratory workers KW - mortality KW - neoplasms KW - occupational medicine KW - workers KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - cancers KW - death rate KW - Department of Agriculture KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - General and gene-specific DNA repair. AU - Snyderwine, E. G. AU - Bohr, V. A. JO - AgBiotech News and Information JF - AgBiotech News and Information Y1 - 1992/// VL - 4 IS - 2 SP - 45N EP - 52N CY - Wallingford; UK PB - CABI Publishing AD - Snyderwine, E. G.: Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37-5C25, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 20063048161. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - DNA repair plays an important role in preventing the deleterious consequences of DNA damage. Deficiencies in DNA repair seen in certain hereditary disorders are associated with a predisposition to cancer. Recently, there have been some important advances in the field of DNA repair. One of them is the ability to study DNA damage and repair at the gene level. This led to the discovery of the intragenomic heterogeneity of DNA repair processes. This heterogeneity of DNA damage and repair is discussed in detail in this review, in the light of its importance in the molecular biology of DNA repair and the process of carcinogenesis. KW - carcinogenesis KW - carcinogens KW - DNA repair KW - genes KW - genomes KW - neoplasms KW - reviews KW - cancers KW - Human Genetics and Molecular Medicine (VV080) (New June 2002) KW - Non-communicable Human Diseases and Injuries (VV600) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063048161&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of Rickettsia rickettsii in saliva, haemolymph and triturated tissues of Dermacentor andersoni ticks by polymerase chain reaction. AU - Gage, K. L. AU - Gilmore, R. D. AU - Karstens, R. H. AU - Schwan, T. G. JO - Molecular and Cellular Probes JF - Molecular and Cellular Probes Y1 - 1992/// VL - 6 IS - 4 SP - 333 EP - 341 SN - 0890-8508 AD - Gage, K. L.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA. N1 - Accession Number: 19950802700. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Diagnostic assays using polymerase chain reaction (PCR) were developed for identifying rickettsial infections in ticks. The assays amplified a 500 bp fragment from the gene encoding the rOMP B protein of R. rickettsii. The selected primers amplified fragments of the predicted size from all spotted fever group rickettsiae tested. No amplified products were detected when typhus group rickettsiae were assayed. Using techniques described in this study, the predicted product was reliably amplified from saliva, haemolymph and triturated tissues of D. andersoni. Samples derived from infected ticks preserved in 70% ethanol also were suitable for amplification by PCR, but similar assays performed with infected ticks preserved in 5% buffered formalin seldom gave positive results. KW - detection KW - disease vectors KW - polymerase chain reaction KW - Rocky Mountain spotted fever KW - tickborne diseases KW - Acari KW - Arachnida KW - Dermacentor andersoni KW - Ixodidae KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802700&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi. AU - Rosa, P. A. AU - Schwan, T. AU - Hogan, D. JO - Molecular Microbiology JF - Molecular Microbiology Y1 - 1992/// VL - 6 IS - 20 SP - 3031 EP - 3040 SN - 0950-382X AD - Rosa, P. A.: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19930517673. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions is described. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp epitopes. Antigenic variation in Osp through recombination may be relevant to the persistence of B. burgdorferi in an infected host, and has important implications for the utility of OspA and OspB as diagnostic or vaccine candidates for Lyme disease. Also described is Osp variation arising from nonsense mutations and sequence divergence, which may also represent significant sources of Osp polymorphism. KW - Antigenic variation KW - Antigens KW - Chimaeras KW - genes KW - Molecular genetics KW - Nucleotide sequences KW - proteins KW - recombination KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenic polymorphism KW - antigenicity KW - bacterium KW - biochemical genetics KW - chimeras KW - DNA sequences KW - genetic recombination KW - immunogens KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517673&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Surface antigen variability and variation in Giardia lamblia. AU - Nash, T. JO - Parasitology Today JF - Parasitology Today Y1 - 1992/// VL - 8 IS - 7 SP - 229 EP - 234 AD - Nash, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930800327. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - This review of antigenic variation in Giardia deals with: heterogeneity among isolates; antigenic variation in vitro; antigenic variation in vivo; the nature of VSPs (variant-specific surface proteins; the control of antigenic variation). KW - Antigenic variation KW - antigens KW - Human diseases KW - parasites KW - Reviews KW - variation KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - Giardia lamblia KW - immunogens KW - surface KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930800327&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular detection of persistent Borrelia burgdorferi in a man with dermatomyositis. AU - Fraser, D. D. AU - Kong, L. I. AU - Miller, F. W. JO - Clinical and Experimental Rheumatology JF - Clinical and Experimental Rheumatology Y1 - 1992/// VL - 10 IS - 4 SP - 387 EP - 390 SN - 0392-856X AD - Fraser, D. D.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940501550. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A 40-year-old man with a several year history of various immunological disorders, including anti-Jo-1 autoantibody positive dermatomyositis, developed clinical Lyme disease after being bitten by a tick (in the USA). The patient was treated with oral tetracycline and his initial symptoms resolved; however, he suffered an exacerbation of his muscle disease which was difficult to control despite cytotoxic therapy. Antibiotic therapy was reinstituted after B. burgdorferi was detected in the patient's peripheral blood leukocytes by the polymerase chain reaction (PCR). All serologic, T-cell stimulation and Western blot analyses, however, were negative. The patient's disease responded to oral ampicillin, probenicid therapy and concurrent cytotoxic therapy. Subsequent leukocyte PCR testing has been negative for the causative agent of Lyme disease. This case may provide an example of the in vivo immuno-modulatory effects of spirochaetes in human autoimmune disease. In addition, this case emphasizes the potential clinical utility of PCR technology in evaluating the persistent sero-negative Lyme disease which may occur in immunocompromised individuals. KW - case reports KW - diagnosis KW - immunocompromised hosts KW - leukocytes KW - Lyme disease KW - polymerase chain reaction KW - rheumatism KW - USA KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - dermatomyositis KW - leucocytes KW - lyme borreliosis KW - PCR KW - United States of America KW - white blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940501550&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Malaria transmission-blocking vaccines. AU - Kaslow, D. C. AU - Bathurst, I. C. AU - Barr, P. J. JO - Trends in Biotechnology JF - Trends in Biotechnology Y1 - 1992/// VL - 10 IS - 11 SP - 388 EP - 391 SN - 0167-7799 AD - Kaslow, D. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19950805462. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology N2 - The development of malaria transmission-blocking vaccines by targeting surface antigens of the sexual stages of Plasmodium falciparum is reviewed under the following headings: current malaria vaccine development; early extracellular sexual stage target antigens; Pfs25, a model for late sexual stage target antigens; Pfs25 expressed in recombinant vaccinia virus; Pfs25 expressed in yeast. KW - antigens KW - developmental stages KW - human diseases KW - immunization KW - live vaccines KW - malaria KW - parasites KW - reviews KW - surface antigens KW - vaccines KW - Apicomplexa KW - man KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - attenuated vaccines KW - growth phase KW - immune sensitization KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805462&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of immunity to parasites by T cells and T cell-derived cytokines. AU - Sher, A. AU - Coffman, R. L. JO - Annual Review of Immunology JF - Annual Review of Immunology Y1 - 1992/// VL - 10 SP - 385 EP - 409 SN - 0732-0582 AD - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879433. Publication Type: Journal Article. Language: English. Number of References: 133 ref. Subject Subsets: Protozoology; Helminthology N2 - Current research on T-cell/parasite interactions is surveyed, with particular emphasis on those responses thought to play a functional role in immunity or immunopathology and on models that have provided general insights into the mechanisms governing T lymphocyte induction and regulation. The paper is organized around the roles of the different T-cell subsets and T-cell-mediated regulatory mechanisms in the immune response to parasites, rather than around a phylogenetic survey of different parasite genera. Topics discussed include regulation of cutaneous leishmaniasis by CD4+ T-cell subsets, immunity against the asexual blood stages of malaria, immunity against helminths, CD4+-dependent immunopathology, vaccine-induced immunity against Theileria parva in cattle, vaccine-induced immunity against pre-erythrocytic stages of malaria, resistance against Trypanosoma cruzi, protective immunity and control of reactivation in Toxoplasma gondii infection, immunoregulation by CD8+ lymphocytes, cross-regulation of CD4+ subsets by cytokines, cytokine inhibition of antiparasite effector responses and functions, and regulation by antiidiotypic T cells. KW - Cytokines KW - Helminths KW - Human diseases KW - immune response KW - Immunity KW - Parasites KW - reviews KW - T lymphocytes KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879433&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aerosolized pentamidine: a well-tolerated mode of prophylaxis against Pneumocystis carinii pneumonia in older children with human immunodeficiency virus infection. AU - Orcutt, T. A. AU - Godwin, C. R. AU - Pizzo, P. A. AU - Ognibene, F. P. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1992/// VL - 11 IS - 4 SP - 290 EP - 294 SN - 0891-3668 AD - Orcutt, T. A.: F.P. Ognibene, Critical Care Medicine Department, Building 10, Room 7D-43, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920881465. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - Aerosolized pentamidine as prophylaxis against Pneumocystis carinii pneumonia is described for the first time in children with HIV infection. The tolerance of monthly doses of aerosolized pentamidine (300 mg using the Respigard II nebulizer) was assessed in older children. During a 21-month period 22 patients (age range 3- 15 years; mean age 9.8 years ± 0.6 years) received a total of 185 treatments. 5 patients developed reversible bronchospasm requiring bronchodilators; no patients developed oxygen desaturation. None of these patients developed P. carinii pneumonia. The study suggests that aerosolized pentamidine as prophylaxis against P. carinii in older children is well tolerated. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - adverse effects KW - aerosols KW - children KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pentamidine KW - Pneumocystis carinii pneumonia KW - prophylaxis KW - Treatment KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - adverse reactions KW - AIDS KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881465&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii and Mycobacterium avium-intracellulare infection of the choroid. AU - Whitcup, S. M. AU - Fenton, R. M. AU - Pluda, J. M. AU - Smet, M. D. de AU - Nussenblatt, R. B. AU - Chan, C. C. JO - Retina (Philadelphia) JF - Retina (Philadelphia) Y1 - 1992/// VL - 12 IS - 4 SP - 331 EP - 335 SN - 0275-004X AD - Whitcup, S. M.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806612. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology N2 - The case is reported of a 44-year-old man with AIDS and P. carinii choroiditis who was treated with iv trimethoprim and sulfamethoxazole, followed by iv trimethoprim and dapsone. The choroidal lesions failed to resolve in spite of 6 weeks treatment. The patient died from massive pulmonary infection caused by P. carinii, Mycobacterium avium-intracellulare and cytomegalovirus infections. Histology and electron microscopy revealed choroidal infection by both P. carinii and M. avium-intracellulare. It is thought that failure of the choroidal lesions of P. carinii to resolve may have been due to inadequate antimicrobial levels after the first week of treatment or the lack of infiltrating inflammatory cells in the choroid related to the patient's severe lymphopenia. KW - acquired immune deficiency syndrome KW - case reports KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - interactions KW - mixed infections KW - opportunistic infections KW - parasites KW - Maryland KW - North America KW - USA KW - bacteria KW - man KW - Mycobacterium avium complex KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - prokaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterium KW - fungus KW - human immunodeficiency virus KW - multiple infections KW - Mycobacterium avium-intracellulare KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806612&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of epidemic infectious diseases in the discovery of America. AU - Bianchine, P. J. AU - Russo, T. A. JO - Allergy Proceedings JF - Allergy Proceedings Y1 - 1992/// VL - 13 IS - 5 SP - 225 EP - 232 AD - Bianchine, P. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930516872. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The role of diseases such as smallpox, measles, louse-borne typhus, yellow fever and malaria in the European conquest of the Americas is discussed. KW - History KW - human diseases KW - Malaria KW - Measles KW - Smallpox KW - Yellow fever KW - America KW - Caribbean KW - Central America KW - North America KW - America KW - Souh America KW - Typhus KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930516872&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful treatment of systemic Exophiala dermatitidis infection in a patient with chronic granulomatous disease. AU - Kenney, R. T. AU - Kwon-Chung, K. J. AU - Waytes, A. T. AU - Melnick, D. A. AU - Pass, H. I. AU - Merino, M. J. AU - Gallin, J. I. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 14 IS - 1 SP - 235 EP - 242 SN - 1058-4838 AD - Kenney, R. T.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211980. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 65277-42-1. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 21-yr-old woman with autosomal recessive chronic granulomatous disease of childhood who was found to have a progressive pulmonary and central nervous system infection with E. [Wangiella] dermatitidis. The patient responded to an aggressive, multifaceted therapeutic approach involving surgical resection of the pulmonary source and medical therapy with amphotericin B (total dose 2 g), flucytosine (500 mg 4 times daily) or ketoconazole (200 mg/d), and transfused white cells, followed by a prolonged course of fluconazole (2 yrs). KW - amphotericin B KW - Antifungal agents KW - fluconazole KW - flucytosine KW - generalized infections KW - hosts KW - infections KW - ketoconazole KW - predisposition KW - therapy KW - USA KW - Exophiala dermatitidis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Herpotrichiellaceae KW - Chaetothyriales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Exophiala KW - 5-fluorocytosine KW - chronic granulomatous disease KW - fungistats KW - fungus KW - therapeutics KW - United States of America KW - Wangiella KW - Wangiella dermatitidis KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211980&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vascular catheter-associated fungemia in patients with cancer: analysis of 155 episodes. AU - Lecciones, J. A. AU - Lee, J. W. AU - Navarro, E. E. AU - Witebsky, F. G. AU - Marshall, D. AU - Steinberg, S. M. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 14 IS - 4 SP - 875 EP - 883 SN - 1058-4838 AD - Lecciones, J. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921212027. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 155 episodes of central venous catheter-associated fungaemia among inpatients at the National Cancer Institute, Maryland, during a 10-yr period were reviewed. Candida spp. (C. albicans, C. tropicalis, C. parapsilosis, C. [Torulopsis] glabrata, C. lusitaniae, C. guilliermondii, C. krusei and C. pseudotropicalis [C. kefyr]) accounted for 98% of episodes; Malassezia furfur and Saccharomyces cerevisiae were isolated from one case each. Fungaemia was documented by culture of blood drawn through catheters in 50% of cases and by culture of both catheter-drawn and peripheral blood in 39%; mortality and the rate of dissemination were similar for these 2 groups. Four management strategies were used: catheter removal, antifungal therapy (with amphotericin B), both or neither; indications for the use of both modes of treatment included fever, neutropenia, long-term indwelling catheterization, positive cultures of both catheter-drawn and peripheral blood, isolation of C. tropicalis and fungal isolation from 2 or more blood cultures. Disseminated fungal infection was documented in 82% of cases with these features but also in 35% of the less severe cases treated only with catheter removal. In addition, 9 (82%) of 11 cases managed only with antifungal therapy had a negative outcome (either death from disseminated infection or the recurrence of fevers and/or fungaemia), suggesting that intravascular catheters should be removed in fungaemia. It is concluded that virtually all cases of catheter-associated fungaemia in patients with cancer are clinically significant and require prompt therapy with amphotericin B. KW - blood KW - catheters KW - hosts KW - infections KW - neoplasms KW - predisposition KW - USA KW - Blastodendrion arztii KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida kefyr KW - Candida lusitaniae KW - Candida parapsilosis KW - Candida tropicalis KW - Malassezia furfur KW - man KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Malassezia KW - Malasseziales KW - Ustilaginomycotina KW - Basidiomycota KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Saccharomyces KW - Saccharomycetaceae KW - Torulopsis KW - Pezizomycotina KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Blastodendrion KW - cancers KW - Candida guilliermondii KW - Candida krusei KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212027&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prophylaxis for Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus. AU - Kovacs, J. A. AU - Masur, H. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 14 IS - 5 SP - 1005 EP - 1009 SN - 1058-4838 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA. N1 - Accession Number: 19930883359. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology N2 - Following the initial observation that trimethoprim- sulfamethoxazole can prevent Pneumocystis carinii pneumonia (PCP) in HIV positive patients with Kaposi's sarcoma, initiating prophylaxis for PCP infection in all patients with <200 CD4 cells/mm³ has become accepted practice. This prophylactic intervention has been found not only to reduce the development of PCP but also to prolong life. The authors of this AIDS commentary first reviewed prophylaxis for PCP 3 years ago. This article updates their review, placing currently available information into clinical perspective and outlining a plan for the clinician to follow based on recent studies. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - aerosols KW - antiprotozoal agents KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pentamidine KW - Pneumocystis carinii pneumonia KW - prophylaxis KW - reviews KW - Treatment KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - trimethoprim sulfamethoxazole KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful treatment of Paecilomyces variotii infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections. AU - Williamson, P. R. AU - Kwon-Chung, K. J. AU - Gallin, J. I. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 14 IS - 5 SP - 1023 EP - 1026 SN - 1058-4838 AD - Williamson, P. R.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921212077. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 1397-89-3, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in an 8-yr-old boy with chronic granulomatous disease who developed a soft tissue infection of the right heel after riding on a motor scooter. Infection was insidious, and minor heel pain and fevers occurred only on the day interferon-γ was injected. Soft tissue biopsy showed hyphal elements and P. variotii grew in culture. The infection was treated with amphotericin B for 7 wks (total dose 40 mg/kg) followed by 1 yr of therapy with itraconazole (100 mg twice daily). Complete cure was achieved during the follow-up period of 10 months. Previously reported cases of infection caused by Paecilomyces spp. are reviewed. KW - amphotericin B KW - Antifungal agents KW - hosts KW - infections KW - itraconazole KW - predisposition KW - therapy KW - USA KW - man KW - Paecilomyces variotii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Paecilomyces KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chronic granulomatous disease KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212077&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental antifungal chemotherapy in granulocytopenic animal models of disseminated candidiasis: approaches to understanding investigational antifungal compounds for patients with neoplastic diseases. AU - Walsh, T. J. AU - Lee, J. W. AU - Roilides, E. AU - Francis, P. AU - Bacher, J. AU - Lyman, C. A. AU - Pizzo, P. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 14 IS - Suppl. 1 SP - S139 EP - S147 SN - 1058-4838 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921212103. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 59 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 84625-61-6, 79404-91-4. Subject Subsets: Medical & Veterinary Mycology N2 - A review of recent approaches to pre-clinical laboratory investigation of promising antifungal compounds, which may have potential utility in granulocytopenic patients is presented. A particularly useful strategy is the study of persistently granulocytopenic rabbit models of acute, subacute, and chronic forms of disseminated Candida albicans infection. When the antifungal triazoles (fluconazole, itraconazole, and SCH 39304) were each evaluated for use as preventive, early treatment, or delayed treatment in the different models, the triazoles were consistently more active when used for preventive and early treatment than for delayed treatment. These triazoles were as active as amphotericin B plus flucytosine (AB + FC) when used for early treatment but were less active than AB + FC when used for delayed treatment. Several lipid formulations of amphotericin B demonstrate reduced nephrotoxicity at higher safely achievable dosages in comparison to those of deoxycholate amphotericin B in several models of disseminated candidosis. When administered to follow non-linear saturable Michaelis-Menten-type plasma pharmacokinetics, the antifungal activity of cilofungin was significantly augmented. It is concluded that thoughtfully designed and carefully conducted laboratory investigations in appropriate animal models of disseminated candidosis can provide a scientific foundation and guide for development of clinical protocols investigating new approaches to prevention and treatment of invasive candidosis in granulocytopenic patients. KW - amphotericin B KW - Antifungal agents KW - cilofungin KW - fluconazole KW - flucytosine KW - infections KW - itraconazole KW - predisposition KW - therapy KW - Candida albicans KW - Rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 5-fluorocytosine KW - Focus on fungal infections, an update on diagnosis and treatment KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - SCH 39304 KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212103&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emergence of unusual opportunistic pathogens in AIDS: a review. AU - Gradon, J. D. AU - Timpone, J. G. AU - Schnittman, S. M. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 15 IS - 1 SP - 134 EP - 157 SN - 1058-4838 AD - Gradon, J. D.: Medical Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD 20892, USA. N1 - Accession Number: 19921212511. Publication Type: Journal Article. Language: English. Number of References: 160 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - Unusual opportunistic pathogens emerging in AIDS patients are extensively reviewed. Organisms causing pulmonary infections, skin and soft-tissue lesions, infections of the nervous system, disseminated infections due to fungi such as Penicillium marneffei, Histoplasma capsulatum, Sporobolomyces salmonicolor, Fusarium spp., Aureobasidium pullulans and Pseudallescheria boydii, due to Pneumocystis carinii, bacteria, viruses, Leishmania donovani and disseminated microsporidial infections, joint infections, infections of the head, gastrointestinal tract and cardiac abnormalities are discussed. KW - acquired immune deficiency syndrome KW - clinical aspects KW - databases KW - HIV infections KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Information KW - Mycoses KW - Opportunistic infections KW - parasites KW - predisposition KW - reviews KW - Leishmania donovani KW - Man KW - Microspora KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - AIDS KW - clinical picture KW - Computer search KW - data banks KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Unusual opportunistic pathogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cutaneous leishmaniasis: review of 59 cases seen at the National Institutes of Health. AU - Melby, P. C. AU - Kreutzer, R. D. AU - McMahon-Pratt, D. AU - Gam, A. A. AU - Neva, F. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 15 IS - 6 SP - 924 EP - 937 SN - 1058-4838 AD - Melby, P. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19930883174. Publication Type: Journal Article. Language: English. Number of References: 103 ref. Subject Subsets: Protozoology N2 - Fifty-nine cases of cutaneous leishmaniasis seen at the National Institutes of Health in Bethesda, USA, are reviewed. This group of patients was unique in that the majority were American civilians, their disease was acquired in many parts of the world, and their illnesses represented all points on the clinical spectrum of cutaneous disease. Cutaneous disease acquired in the New World usually consisted of one or two lesions, while multiple lesions often characterized Old World infections with Leishmania major. Patients with chronic relapsing or diffuse cutaneous leishmaniasis were native to endemic areas and were infected at an early age. Diagnosis with culture and identification of the parasite was instrumental in the selection of optimal therapy. KW - cutaneous leishmaniasis KW - human diseases KW - imported infections KW - parasites KW - reviews KW - Maryland KW - North America KW - USA KW - Leishmania KW - Leishmania major KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883174&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics and antifungal therapy. AU - Francis, P. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1992/// VL - 15 IS - 6 SP - 1003 EP - 1018 SN - 1058-4838 AD - Francis, P.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931213788. Publication Type: Journal Article. Language: English. Number of References: 117 ref. Registry Number: 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - The safety and tolerability of flucytosine was evaluated in 17 patients with cancer or aplastic anaemia during a 2.5-yr period. The combination of amphotericin B plus flucytosine eradicated mycosis (due to Candida albicans, Aspergillus, Torulopsis glabrata, C. guilliermondii, C. tropicalis, Cryptococcus neoformans) in 12 (71%) of 17 patients, whereas 3 (18%) of 17 died of progressive fungal infection (due to Candida tropicalis or A. fumigatus). Serial serum levels of flucytosine measured by a creatinine iminohydrolase assay permitted reliable dosage adjustment. During therapy, only 2 (12%) of 17 patients had elevated mean serum levels of flucytosine (>100 µg/ml) and 3 (18%) other patients had transiently elevated levels. Paired serum samples (n=45) obtained at steady state during therapy with orally administered flucytosine showed similar peak and trough levels. Adverse effects of flucytosine therapy included 1 case each of reversible nausea, diarrhoea, elevated transaminase levels and thrombocytopenia. No cases of bone marrow aplasia, enterocolitis, hepatitis or death due to flucytosine toxicity were encountered. It is concluded that flucytosine in combination with amphotericin B is well tolerated in myelosuppressed patients when serum flucytosine levels are serially monitored. The mechanism of action, mechanism of resistance, in vitro and in vivo antifungal activity, clinical antifungal activity, pharmacokinetics and toxicity of flucytosine are also reviewed. KW - Antifungal agents KW - Flucytosine KW - hosts KW - immunosuppression KW - infections KW - predisposition KW - reviews KW - therapy KW - USA KW - Aspergillus KW - Aspergillus fumigatus KW - Blastodendrion arztii KW - Candida albicans KW - Candida glabrata KW - Candida parapsilosis KW - Cryptococcus neoformans KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Blastodendrion KW - 5-fluorocytosine KW - Candida guilliermondii KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - Torulopsis glabrata KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931213788&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resting metabolic rate and body composition of Pima Indian and Caucasian children. AU - Fontvieille, A. M. AU - Dwyer, J. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1992/// VL - 16 IS - 8 SP - 535 EP - 542 SN - 0307-0565 AD - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19931465431. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - Body composition (bioelectrical resistance) and resting metabolic rate (RMR) were estimated in 43 Pima Indian children (mean age ±s.d. 9.9±1.1) and 42 Caucasian children (9.7±1.2 years old). Pima children were taller (143±9 vs. 137±8 cm, P <0.001), heavier (48.6±15.8 vs. 32.9±7.8 kg, P <0.001) and fatter (39±10 vs. 24±7% fat, P <0.001) than Caucasians. Absolute values of RMR were higher in Pimas than in Caucasians (6234±1201 vs. 5171±715 kJ/day, P <0.001), but similar when adjusted for differences in body size, body composition and sex. A decreased RMR in Pima as compared to Caucasian children was not found. Therefore, the high prevalence of obesity in Pima children at 10 years old suggested that excess energy intake and/or low levels of physical activity was the major aetiological factor, though the possibility that a low metabolic rate might be a predisposing factor at an earlier age was not discounted. KW - body composition KW - children KW - ethnic groups KW - metabolism KW - obesity KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465431&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for independent genetic influences on obesity in middle age. AU - Fabsitz, R. R. AU - Carmelli, D. AU - Hewitt, J. K. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1992/// VL - 16 IS - 9 SP - 657 EP - 666 SN - 0307-0565 AD - Fabsitz, R. R.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931465752. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - The relative contribution of genes and environmental factors to obesity throughout adulthood was assessed. Data from the National Heart, Lung and Blood Institute Twin Study (USA) was used and analyses of obesity were performed on 124 pairs of monozygotic and and 119 pairs of dizygotic white male twins with complete data for 4 examinations spanning a 43-year period of adult life. Genetic, shared environment and non-shared environment contributions to body mass index were estimated. KW - age KW - body measurements KW - body weight KW - genetics KW - genotype nutrition interaction KW - obesity KW - twins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465752&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. AU - Seidell, J. C. AU - Muller, D. C. AU - Sorkin, J. D. AU - Andres, R. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1992/// VL - 16 IS - 9 SP - 667 EP - 674 SN - 0307-0565 AD - Seidell, J. C.: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. N1 - Accession Number: 19931465745. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition N2 - 775 men, 18 to 98 years old, participating in the Baltimore Longitudinal Study on Aging (USA) were followed for an average of 10 years. Resting metabolic rate (RMR) and fasting respiratory exchange ratio (RER) were measured by indirect calorimetry on their 1st visit and related to subsequent weight change. Deviations from the predicted value of RMRs (predicted from their estimated fat-free mass) were calculated. Average weight change was 0.07 kg (s.d. 6.4); 122 men (15.3%) gained >5 kg and 40 (5.2%) >10 kg during the follow-up. After adjustment for initial age, body mass index, fat-free mass, and duration of follow-up, RER, but not RMR or deviations from predicted RMR, was positively related to weight change (P<0.001). Major weight gain (from at least 5 to at least 15 kg) was related to initial RER in non-obese men only (initial BMI <25 kg/m²). From Cox proportional hazard regression analyses the adjusted relative risk of gaining 5 kg or more in initially non-obese men with a fasting RER of ≥0.85 was calculated to be 2.42 (95% confidence interval: 1.10-5.32) compared with men with a fasting RER <0.76. It is concluded that a relatively high fasting RER is a weak but significant predictor of substantial weight gain in non-obese white men. KW - aging KW - body weight KW - energy exchange KW - men KW - metabolism KW - respiration KW - respiratory quotient KW - resting energy exchange KW - weight gain KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ageing KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokines and their role in the pathophysiology of cancer cachexia. AU - McNamara, M. J. AU - Alexander, R. AU - Norton, J. A. JO - Journal of Parenteral and Enteral Nutrition JF - Journal of Parenteral and Enteral Nutrition Y1 - 1992/// VL - 16 IS - Suppl. 6 SP - 50S EP - 55S SN - 0148-6071 AD - McNamara, M. J.: J. A. Norton, Surgical Metabolism Section, Surgery Branch, National Cancer Institute, NIH, Bldg 10, Room 2B07, Bethesda, MD 20892, USA. N1 - Accession Number: 19931461457. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 62 ref. Registry Number: 9008-11-1. Subject Subsets: Human Nutrition N2 - The role of cytokines (tumour necrosis factor, interleukin-1, interleukin-6, interferon-γ and differentiation factor) in the pathophysiology of neoplasm cachexia is reviewed. KW - cachexia KW - interferon KW - interleukins KW - Neoplasms KW - reviews KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - American Society for Parenteral and Enteral Nutrition KW - cancers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461457&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality of workers employed at organochlorine pesticide manufacturing plants - an update. AU - Brown, D. P. JO - Scandinavian Journal of Work, Environment & Health JF - Scandinavian Journal of Work, Environment & Health Y1 - 1992/// VL - 18 IS - 3 SP - 155 EP - 161 SN - 0355-3140 AD - Brown, D. P.: Office of Occupational Health and Technical Services, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19930514537. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 309-00-2, 57-74-9, 12789-03-6, 50-29-3, 60-57-1, 72-20-8, 76-44-8. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology; Public Health N2 - A previous mortality study among 4 organochlorine pesticide manufacturers in the USA [see D. Ditraglia et al. (1981) Scandinavian Journal of Work, Environment & Health, 7 (Suppl. 4): 140-146] was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and DDT. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumours of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumours, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer.<new para>ADDITIONAL ABSTRACT:<new para>A previous mortality study among four organochlorine pesticide manufacturers was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and dichlorodiphenyltrichloroethane. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumours of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumours, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer. AS KW - agricultural entomology KW - Aldrin KW - Carcinogens KW - Carcinoma KW - Chlordane KW - DDT KW - Dieldrin KW - Endrin KW - Epidemiology KW - exposure KW - Heptachlor KW - Human diseases KW - insecticides KW - liver KW - mortality KW - Neoplasms KW - Nontarget effects KW - Occupational hazards KW - occupational medicine KW - occupations KW - organochlorine compounds KW - Organochlorine insecticides KW - Pesticides KW - poisoning KW - Toxicity KW - workers KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - cancer sites KW - cancers KW - death rate KW - dicophane KW - Heptachor KW - organchlorine manufacturers KW - organic chlorine compounds KW - toxicosis KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Occupational Health and Safety (VV900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930514537&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clues to cancer etiology from studies of farmers. AU - Blair, A. AU - Zahm, S. H. AU - Pearce, N. E. AU - Heineman, E. F. AU - Fraumeni, J. F., Jr. JO - Scandinavian Journal of Work, Environment & Health JF - Scandinavian Journal of Work, Environment & Health Y1 - 1992/// VL - 18 IS - 4 SP - 209 EP - 215 SN - 0355-3140 AD - Blair, A.: National Cancer Institute, Executive Plaza North, Room 418, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020032. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Subject Subsets: Public Health KW - aetiology KW - agriculture KW - exposure KW - farm workers KW - farmers KW - neoplasms KW - occupations KW - pesticides KW - research KW - reviews KW - workers KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancer research KW - cancers KW - causal agents KW - etiology KW - studies KW - Pesticides and Drugs (General) (HH400) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Research (AA500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020032&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phenylalkenals in ponerine (Leptogenys sp.) and myrmicine (Pogonomyrmex sp.) ants. AU - Fales, H. M. AU - Jones, T. H. AU - Jaouni, T. AU - Blum, M. S. AU - Schmidt, J. O. JO - Journal of Chemical Ecology JF - Journal of Chemical Ecology Y1 - 1992/// VL - 18 IS - 6 SP - 847 EP - 854 SN - 0098-0331 AD - Fales, H. M.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941102529. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology N2 - Cephalic extracts of 2 unrelated species of formicid, Leptogenys processionalis and Pogonomyrmex rugosus, contained 2-phenylpropenal and 2-phenyl-2-butenal, while 2 other species related to L. processionalis, L. chinensis and L. kitteli, lacked either. L. kitteli also produced a tetrasubstituted pyrazine found previously only in 2 New Zealand ants in the genus Mesoponera. The chemical reactivity of the phenylalkenals suggested that their function was to repel attacks by predators. KW - agricultural entomology KW - animal physiology KW - Behaviour KW - biochemistry KW - Biology KW - Chemical composition KW - defensive secretions KW - Insect pests KW - Natural enemies KW - predators KW - Predatory insects KW - Pyrazines KW - secretions KW - Social insects KW - New Zealand KW - arthropods KW - Formicidae KW - Hymenoptera KW - insects KW - Pogonomyrmex rugosus KW - invertebrates KW - animals KW - eukaryotes KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - Pogonomyrmex KW - Formicidae KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - 2-Phenyl-2-butenal KW - 2-Phenylpropenal KW - behavior KW - Leptogenys KW - Leptogenys chinensis KW - Leptogenys kitteli KW - Leptogenys processionalis KW - Mesoponera KW - pest insects KW - Phenylalkenals KW - predaceous insects KW - predacious insects KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000) KW - Biological Control (HH100) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Chemistry (ZZ600) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941102529&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Three fatal cases of disseminated mucormycosis associated with respiratory distress syndrome and shock in patients with hematologic malignancies. AU - Agh, F. AU - Spanik, S. AU - Gyarfas, J. AU - Horváth, J. AU - Krčméry, V., Jr. T2 - Infection JO - Infection JF - Infection Y1 - 1992/// VL - 20 IS - 2 SP - 112 EP - 112 SN - 0300-8126 AD - Agh, F.: National Cancer Institute, 83310 Bratislava, Czechoslovakia. N1 - Accession Number: 19921212274. Publication Type: Correspondence. Language: English. Number of References: 2 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Three fatal cases of pulmonary zygomycosis are reported in patients (68-, 42- and 54-yr-old men) with leukaemia and lymphoma. All patients suffered neutropenia and were treated with steroids. The clinical course was rapid in each case and was associated with septic shock, acute respiratory, renal and hepatic failure. Within 72 h of X-rays revealing the first signs of pneumonia, the patients died. At autopsy, disseminated infections were found in all cases. Mucor sp. was identified in 2 cases. KW - generalized infections KW - hosts KW - infections KW - lungs KW - neoplasms KW - predisposition KW - ZYGOMYCOSIS KW - Czechoslovakia KW - man KW - Mucor KW - Mucoraceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mucoraceae KW - Mucorales KW - Mucoromycotina KW - Zygomycota KW - fungi KW - Central Europe KW - Europe KW - cancers KW - fungus KW - phycomycosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212274&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for epithelial ovarian cancer in Beijing, China. AU - Chen, Y. AU - Wu, P. C. AU - Lang, J. H. AU - Ge, W. J. AU - Hartge, P. AU - Brinton, L. A. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1992/// VL - 21 IS - 1 SP - 23 EP - 29 SN - 0300-5771 AD - Chen, Y.: (L.A. Brinton) Executive Plaza North, Rm. 443, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021486. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The results of a case-control study (112 cases) "suggest that Chinese women have risk factors similar to those of occidental women." KW - epithelium KW - female genitalia KW - genitalia KW - neoplasms KW - ovaries KW - risk factors KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - female genital system KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021486&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of dietary intake of fruits and vegetables on the odds ratio of lung cancer among Yunnan tin miners. AU - Forman, M. R. AU - Yao, S. X. AU - Graubard, B. I. AU - Qiao, Y. L. AU - McAdams, M. AU - Mao, B. L. AU - Taylor, P. R. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1992/// VL - 21 IS - 3 SP - 437 EP - 441 SN - 0300-5771 AD - Forman, M. R.: Cancer Prevention Studies Branch, CPRP, DCPC, National Cancer Institute, Executive Plaza North, Room 211C, Bethesda, MD 20892, USA. N1 - Accession Number: 19931458830. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - All newly diagnosed patients with lung cancer (n = 183) among male tin miners of Yunnan Province, China in 1985-86 and age-sex matched occupational controls (n = 183 aged 45-79 years) were interviewed. The cancer patients were interviewed within 3 months of diagnosis. The questionnaire included information about the diet as well as employment and smoking histories. Over 95% of cases and controls were current smokers. The 27-item food frequency questionnaire included 11 fruits and vegetables rich in vitamin A and/or carotenoids. The effect of dietary intake of fruits and vegetables on risk of lung cancer was examined with adjustments for exposures to radon, arsenic and smoking as previously documented risk factors for lung cancer. Tin miners with reduced intake of yellow and light green vegetables had significantly increased odds ratios (OR) of lung cancer (OR = 2.26 and 2.39 for the lowest 2 quartiles of intake; P = 0.02) among cases compared with controls after multiple logistic regression adjustment for covariates, and this relationship was monotonic. Tin miners with reduced intake of tomatoes had significantly increased adjusted OR of lung cancer (OR = 2.64, 3.09 and 2.36 for the 3 lowest quartiles of intake; P value for trend = 0.04). This is the first study to demonstrate a protective effect of vegetable intake against the strong carcinogenic effects of smoking and occupational exposure. KW - Carcinoma KW - fruit KW - intake KW - lungs KW - vegetables KW - China KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - People's Republic of China KW - vegetable crops KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931458830&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental models of immunization against schistosomes: lessons for vaccine development. AU - James, S. L. JO - Immunological Investigations JF - Immunological Investigations Y1 - 1992/// VL - 21 IS - 5 SP - 477 EP - 493 SN - 0882-0139 AD - James, S. L.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930802155. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Subject Subsets: Helminthology N2 - Experimental models of immunization against Schistosoma are discussed under the headings: attenuated vaccine models; activated macrophages as immune effector cells; hyperimmunization with attenuated parasites; non-living vaccine models; candidate vaccine antigens. Lessons for vaccine development are proposed. KW - disease models KW - helminths KW - immunization KW - Laboratory animals KW - parasites KW - reviews KW - Schistosomiasis KW - Vaccines KW - Digenea KW - Schistosoma KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - immune sensitization KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802155&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Catheter-associated septicaemia due to Trichosporon capitatum. AU - Syčova-Milá, Z. AU - Sufliarsky, J. AU - Trupl, J. AU - Jasenská, Z. AU - Blahvá, M. AU - Krčméry, V., Jr. T2 - Journal of Hospital Infection JO - Journal of Hospital Infection JF - Journal of Hospital Infection Y1 - 1992/// VL - 22 IS - 3 SP - 257 EP - 258 SN - 0195-6701 AD - Syčova-Milá, Z.: Department of Clinical Oncology, National Cancer Institute, Klenova 3, 83310 Bratislava, Slovakia. N1 - Accession Number: 19931215041. Publication Type: Correspondence. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case of fungaemia is reported in a 23-yr-old woman with Hodgkin's disease, who developed neutropenia and fever after chemotherapy. After 3 d, a subclavian catheter was inserted. The fever did not respond to antibiotic treatment. Blood and catheter cultures grew T. capitatum [Blastoschizomyces capitatus] and intravenous amphotericin B (35 mg/d) and oral flucytosine (2 g/d) were administered. Blood samples remained positive for 11 d after the start of amphotericin B therapy and the catheter was removed. Cultures were negative on days 12, 14 and 15, and after 24 d of amphotericin B (total dose 0.8 g), the fever resolved. KW - blood KW - catheters KW - hosts KW - infections KW - predisposition KW - Slovakia KW - man KW - Trichosporon capitatum KW - Blastoschizomyces KW - Dipodascaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Blastoschizomyces capitatus KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931215041&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. AU - Gazzinelli, R. T. AU - Oswald, I. P. AU - Hieny, S. AU - James, S. L. AU - Sher, A. JO - European Journal of Immunology JF - European Journal of Immunology Y1 - 1992/// VL - 22 IS - 10 SP - 2501 EP - 2506 SN - 0014-2980 AD - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950802486. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 74-79-3, 9008-11-1, 130068-27-8, 10102-43-9, 76057-06-2. Subject Subsets: Protozoology; Tropical Diseases N2 - The mechanism of anti-Trypanosoma cruzi activity by interferon (IFN)-γ plus lipopolysaccharide (LPS)-treated macrophages was investigated. A macrophage cell line (IC-21) that failed to produce an appreciable oxidative burst was able to control T. cruzi growth after exposure to IFN-γ alone or IFN-γ plus LPS. Microbicidal functions of both inflammatory macrophages and IC-21 against T. cruzi were inhibited by NG-monomethyl-L-arginine (NGMMA), a competitive inhibitor of L-arginine. Addition of supplemental L-arginine to the culture overcame the capacity of NGMMA to block activated macrophage anti-T. cruzi functions. The ability of NGMMA to reverse both parasite growth inhibition and killing by IFN-γ plus LPS-activated macrophages was correlated with the suppression of nitrite accumulation in culture supernatants. The results implicate the L-arginine-dependent production of nitric oxide in T. cruzi killing by activated macrophages. Both interleukin (IL)-10 and transforming growth factor (TGF)-β inhibited anti-parasite function by IFN-γ-activated macrophages, with optimal doses of 100 units/ml and 0.5 ng/ml, respectively. When used in combination, suboptimal doses of IL-10 and TGF-β produced a synergistic inhibitory effect on the regulation of T. cruzi growth. The ability of IL-10 and TGF-β to suppress microbicidal function was positively correlated with the inhibition of nitrite generation in macrophage culture supernatants. The results predict an in vivo role for IL-10 and TGF-β in promoting parasite survival against the host immune response. KW - arginine KW - immune response KW - in vitro KW - interferon KW - interleukin 10 KW - lipopolysaccharides KW - macrophages KW - nitric oxide KW - parasites KW - transforming growth factor KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - activated KW - growth regulation KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802486&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differentiation of pathogenic Entamoeba histolytica from other intestinal protozoa by riboprinting. AU - Clark, C. G. AU - Diamond, L. S. JO - Archives of Medical Research JF - Archives of Medical Research Y1 - 1992/// VL - 23 IS - 2 SP - 15 EP - 16 SN - 0066-6769 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803769. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Protozoology N2 - Differentiation of the pathogen Entamoeba histolytica from the variety of other amoebae that can infect the human intestinal tract is vital for accurate diagnosis and treatment. Morphology and serology alone are not adequate for positive identification to be achieved. In this study, methods were developed using polymerase chain reaction to amplify amoebic ribosomal RNA genes that allowed either specific detection of E. histolytica or species identification. KW - amoebiasis KW - chemotaxonomy KW - gastrointestinal diseases KW - genes KW - human diseases KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - restriction mapping KW - ribosomal RNA KW - Blastocystis hominis KW - Endamoebidae KW - Endolimax nana KW - Entamoeba coli KW - Entamoeba hartmanni KW - Entamoeba histolytica KW - Entamoeba moshkovskii KW - protozoa KW - Sarcomastigophora KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Endolimax KW - Endamoebidae KW - Entamoeba KW - amebiasis KW - biochemical genetics KW - biochemical taxonomy KW - PCR KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803769&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Amebiasis: a problem solved. What now ? AU - Diamond, L. S. JO - Archives of Medical Research JF - Archives of Medical Research Y1 - 1992/// VL - 23 IS - 4 SP - 157 EP - 161 SN - 0066-6769 AD - Diamond, L. S.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803424. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - In this review, the well documented fact that only 10% of those infected with Entamoeba histolytica develop invasive disease is examined. In attempting to explain this phenomenon it is stated that the evidence that there are 2 morphologically identical but nevertheless distinctly different species (E. histolytica and E. dispar) involved is indisputable. They can be separated by biochemical, immunological and genetic criteria. The importance of recognizing the 2 species and the impact of this on the interpretation of epidemiological data is discussed. KW - Amoebiasis KW - human diseases KW - parasites KW - pathogenicity KW - reviews KW - Entamoeba dispar KW - Entamoeba histolytica KW - man KW - protozoa KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - amebiasis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803424&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The fat and fiber content of foods: what Americans know. AU - Cremer, S. A. AU - Kessler, L. G. JO - Journal of Nutrition Education JF - Journal of Nutrition Education Y1 - 1992/// VL - 24 IS - 3 SP - 149 EP - 152 SN - 0022-3182 AD - Cremer, S. A.: National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951401687. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition KW - composition KW - fats KW - fibre KW - foods KW - nutrition knowledge KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fiber KW - United States of America KW - Human Nutrition (General) (VV100) KW - Food Composition and Quality (QQ500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401687&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of the anorectic drug recognition site during glucoprivic feeding. AU - Angel, I. AU - Hauger, R. L. AU - Giblin, B. A. AU - Paul, S. M. JO - Brain Research Bulletin JF - Brain Research Bulletin Y1 - 1992/// VL - 28 IS - 2 SP - 201 EP - 207 SN - 0361-9230 AD - Angel, I.: Clinical Neuroscience Branch, National Institute of Mental Health, NIH, Bethesda, MD 20985, USA. N1 - Accession Number: 19941408575. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition; Animal Nutrition N2 - The acute effects of 2-deoxy-D-glucose (2-DG)-induced glucoprivic feeding on the anorectic drug recognition site and Na+K+-ATPase in the brain were examined in adult male Sprague Dawley rats and in lean and genetically obese mice. The hyperglycaemia and the induction of feeding caused by the administration of 2-DG to satiated rats and lean mice were associated with significant increases in Na+K+-ATPase activity, and in [³H]ouabain binding and [³H]mazindol binding to the anorectic drug recognition site in hypothalamic membranes. Basal and 2-DG-stimulated values of blood glucose were correlated to the values of hypothalamic [³H]ouabain (r = 0.91, P<0.01) and [³H]mazindol (r = 0.87, P<0.01) binding. A correlation (r = 0.74, P<0.05) was also observed between [³H]mazindol binding and [³H]ouabain supporting the hypothesis that these hypothalamic binding sites are functionally coupled in their response to circulating glucose. Following the intracerebroventricular (ICV) administration of the diabetogenic drug alloxan, 2-DG did not stimulate feeding or increase [³H]mazindol and [³H]ouabain binding sites in the hypothalamic paraventricular area. Since 2-DG still caused hyperglycaemia in alloxan-treated rats, alloxan-induced inactivation of glucoreceptor mechanisms led to an uncoupling of the anorectic drug recognition site from a hypothalamic glucostat. In genetically obese mice (ob/ob), 2-DG also could not induce feeding or increase hypothalamic [³H]ouabain or [³H]mazindol binding, despite a significant hyperglycaemic response. In contrast, 2-DG did increase feeding and the binding of [³H]ouabain and [³H]mazindol to the hypothalamus of lean littermates. The dissociation of the anorectic drug recognition site from blood glucose responses to 2-DG suggests that the glucoprivic feeding response in obese mice is impaired. It is concluded that the [³H]mazindol recognition site and the neuronal Na+K+-ATPase labelled by [³H]ouabain binding constitutes a glucoreceptive system which in response to changes in circulating glucose values modulates feeding. Since the coupling of this anorectic drug recognition site to brain glucostats is defective in genetically obese mice, this system may have an important role in pathological hyperphagia and the development of obesity. KW - anorexia KW - anorexiants KW - appetite KW - blood sugar KW - food intake KW - glucose KW - hypothalamus KW - obesity KW - receptors KW - mice KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anorectics KW - appetite depressants KW - appetite suppressors KW - blood glucose KW - dextrose KW - fatness KW - glucose in blood KW - inappetence KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408575&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Argas (Argas) monolakensis, new species (Acari: Ixodoidea: Argasidae), a parasite of California gulls on islands in Mono Lake, California: description, biology, and life cycle. AU - Schwan, T. G. AU - Corwin, M. D. AU - Brown, S. J. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1992/// VL - 29 IS - 1 SP - 78 EP - 97 SN - 0022-2585 AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19930513993. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Argas monolakensis sp. nov. is described from adults, nymphs and larvae collected from under and around nests of California gulls (Larus californicus) on islands in Mono Lake, Mono County, California, USA, and from specimens reared in the laboratory. This species is closely related to A. cooleyi, a parasite of cliff swallows (Hirundo pyrrhonota), but is easily distinguished by hypostome dentition and roof of Haller's organ in all stages and chaetotaxy of the larvae. This tick was successfully reared and maintained in the laboratory by feeding them on domestic chickens. Larvae require 5-8 days to feed, whereas all postlarval stages feed rapidly within 9-62 min. At Mono Lake, ticks are above ground and seek hosts only at night. The number of nymphal stages varies from 2 to 5 depending on the developmental temperature and sex of the tick. Ticks overwinter at Mono Lake as 2nd- to 5th-stage nymphs and adults. Ovarian diapause is common with preoviposition periods in extreme cases lasting up to 20 months. This tick will readily feed on humans and has the potential to transmit Mono Lake virus (Orbivirus), which has been isolated from an estimated 2-8% of ticks on various islands. KW - Arboviruses KW - Biology KW - Development KW - Diapause KW - Disease vectors KW - Ecology KW - Ectoparasites KW - Hosts KW - new species KW - poultry KW - taxonomy KW - wild animals KW - Wild birds KW - California KW - North America KW - USA KW - Acari KW - Arachnida KW - Argasidae KW - Birds KW - fowls KW - Laridae KW - Larus californicus KW - Man KW - Orbivirus KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Metastigmata KW - Acari KW - vertebrates KW - Chordata KW - Gallus gallus KW - Gallus KW - Phasianidae KW - Galliformes KW - birds KW - Charadriiformes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - Argas KW - Argasidae KW - Larus KW - Laridae KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Argas monolakensis KW - arthropod-borne viruses KW - chickens KW - domesticated birds KW - Mono Lake virus KW - systematics KW - United States of America KW - Taxonomy and Evolution (ZZ380) KW - Animal Behaviour (LL300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513993&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of heat shock on the survival of transgenic Anopheles gambiae (Diptera: Culicidae) under antibiotic selection. AU - Sakai, R. K. AU - Miller, L. H. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1992/// VL - 29 IS - 2 SP - 374 EP - 375 SN - 0022-2585 AD - Sakai, R. K.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930514207. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 1404-04-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - A gene for neomycin resistance linked to a Drosophila hsp 70 heat shock promoter was introduced into the germ line of A. gambiae. Effects of heat shock at 37 and 41°C on the subsequent survival of the transgenic mosquito subjected to selection by the antibiotic G418 were studied. Heat shock did not enhance the survival of untransformed mosquitoes but greatly increased the survival of the transgenic mosquitoes. Survival after heat shock at 41°C was greater than after heat shock at 37°C. KW - Antibiotics KW - biotechnology KW - drug resistance KW - gene expression KW - genetic engineering KW - Heat shock KW - Heat shock proteins KW - Neomycin KW - resistance KW - Transformation KW - transgenics KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - genetic manipulation KW - mosquitoes KW - Pesticides and Drugs (General) (HH400) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Pesticide and Drug Resistance (HH410) KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930514207&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Xenopsylla bantorum is an East African subspecies of X. cheopis (Siphonaptera: Pulicidae). AU - Schwan, T. G. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1992/// VL - 29 IS - 6 SP - 927 EP - 933 SN - 0022-2585 AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19930513311. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The geographic distribution, host associations, and male genital morphology of X. bantorum were examined and compared with the Nilotic and Oriental "strains" of X. cheopis. The more acute shape of the 9th sternite separates X. bantorum from all types of X. cheopis; however, the length of the first process of the male's clasper and the number of setae on this process are significantly different among all 3 groups; the Nilotic strain of X. cheopis is intermediate to the others. Specimens collected from both wild and commensal rodents in Nakuru, Kenya, were all X. bantorum, suggesting that X. cheopis present early in the century that resulted from introductions on Rattus rattus had been absorbed by the native X. bantorum population. These factors and a review of opinions by others concerning the status of X. bantorum demonstrate that this flea is not specifically distinct from X. cheopis. The trinomial X. cheopis bantorum is erected. Furthermore, the Nilotic and Oriental "strains" of X. cheopis are distinguishable morphologically solely by the length of the male's first process. KW - Ectoparasites KW - Geographical distribution KW - Hosts KW - Morphotaxonomy KW - NEW RANK KW - nomenclature KW - Small mammals KW - taxonomy KW - Wild animals KW - Africa KW - East Africa KW - Ethiopia KW - Kenya KW - Arvicanthis niloticus KW - Mastomys natalensis KW - Muridae KW - Pulicidae KW - Rattus rattus KW - Rodents KW - Siphonaptera KW - Xenopsylla bantorum KW - Xenopsylla cheopis KW - Arvicanthis KW - Murinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Siphonaptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - Rattus KW - Xenopsylla KW - Pulicidae KW - Xenopsylla cheopis KW - Africa South of Sahara KW - Africa KW - ACP Countries KW - East Africa KW - Least Developed Countries KW - Developing Countries KW - Anglophone Africa KW - Commonwealth of Nations KW - Mastomys KW - Abyssinia KW - black rat KW - new status KW - Oriental rat flea KW - PRAOMYS NATALENSIS KW - ship rat KW - subspecies KW - systematics KW - Xenopsylla cheopis bantorum KW - Biological Resources (Animal) (PP710) KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Health statistics on older persons. AU - Havlik, R. J. A2 - Munro, H. N. A2 - Schlierf, G. JO - Nestlé Nutrition Workshop Series JF - Nestlé Nutrition Workshop Series Y1 - 1992/// VL - 29 SP - 7 EP - 16 CY - New York; USA PB - Raven Press SN - 0742-2806 SN - 0881678740 AD - Havlik, R. J.: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19921448348. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition KW - health KW - Old age KW - statistics KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448348&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selection of ura5 and ura3 mutants for the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium. AU - Kwon-Chung, K. J. AU - Varma, A. AU - Edman, J. C. AU - Bennett, J. E. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1992/// VL - 30 IS - 1 SP - 61 EP - 69 SN - 0268-1218 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211445. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Spontaneous mutants requiring uracil were isolated from both varieties of C. neoformans by plating on 5-fluoroorotic acid (5-FOA) medium. Of the 36 strs. tested (18 var. neoformans and 18 var. gattii), 24 (12 of each variety) generated 5-FOA-resistant cells requiring uracil for growth. Six of the 12 C. neoformans var. gattii strs. produced ura3 cells while the remaining 6 strs. produced ura5 cells. None of the 12 strs. produced both ura3 cells and ura5 cells. All 12 isolates of var. neoformans, however, produced ura5 cells and 1 produced ura3 as well as ura5 cells. A genetic lesion in the URA5 gene of an isolate of C. neoformans var. gattii was confirmed by complement with the cognate URA5 gene of C. neoformans var. neoformans. The ura3 isolates were tentatively identified by their ability to grow on a medium containing uridine but not on a medium with orotic acid or orotidine. Enzymatic assays for orotidine-5′-phosphate decarboxylase activity confirmed the isolates to be ura3 mutants. Hybridization analysis of total DNA, digested with EcoRI or StuI and probed with pURA5g2, revealed the presence of only one copy of URA5 in the strains of either variety, regardless of the prevalence of ura5 mutants. Extensive polymorphism was observed in the restriction patterns of the fragments containing the URA5 locus. It is concluded that the prevalence of spontaneously arising ura3 mutants among the isolates of C. neoformans var. gattii, but not among the isolates of C. neoformans var. neoformans, is one more biological difference that distinguishes the 2 varieties. KW - genetics KW - mutants KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus neoformans KW - Cryptococcus neoformans var. gattii KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of Leptospira spp., Leptonema illini, and Rickettsia rickettsii for the 39-kilodalton antigen (P39) of Borrelia burgdorferi. AU - Schwan, T. G. AU - Schrumpf, M. E. AU - Gage, K. L. AU - Gilmore, R. D., Jr. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1992/// VL - 30 IS - 3 SP - 735 EP - 738 SN - 0095-1137 AD - Schwan, T. G.: Arthropod-Borne Disease Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515890. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Five serovars of Leptospira interrogans, L. biflexa, Leptonema illini and R. rickettsii were examined and found not to contain the 39-kDa antigen (P39) of B. burgdorferi. The specificity of this antigen and its reactivity with human Lyme disease sera should exclude the possibility of false-positive serum samples from patients having had either leptospirosis or Rocky Mountain spotted fever, as well as tick-borne relapsing fever and syphilis, as reported previously [see W.J. Simpson et al. (1990) Journal of Clinical Microbiology, 28: 1329-1337]. KW - antigens KW - Diagnosis KW - Borrelia burgdorferi KW - Leptonema illini KW - Leptospira KW - Man KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Leptospiraceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Leptonema (Bacteria) KW - antigenicity KW - bacterium KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515890&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody. AU - Schwan, T. G. AU - Gage, K. L. AU - Karstens, R. H. AU - Schrumpf, M. E. AU - Hayes, S. F. AU - Barbour, A. G. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1992/// VL - 30 IS - 4 SP - 790 EP - 795 SN - 0095-1137 AD - Schwan, T. G.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515850. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia hermsii causes a relapsing fever in humans and is one of several species of tick-borne spirochaetes known to occur in the western USA. Spirochaetes observed in the peripheral blood of patients acutely ill have been presumptively identified in the past by the geographic location of exposure and the probable species of tick vector. A monoclonal antibody (H9826) is described that bound to the flagellar protein of B. hermsii but not to those of any of the other species tested, which included B. parkeri, B. turicatae, B. coriaceae, B. anserina, B. burgdorferi and Leptospira interrogans serovar ballum. This antibody bound efficiently to B. hermsii in an indirect immunofluorescence assay and was used to rapidly detect and identify this spirochaete in the peripheral blood of experimentally infected mice and in the central ganglia of Ornithodoros hermsi ticks. KW - Antigens KW - detection KW - Diagnosis KW - Diagnostic techniques KW - Disease vectors KW - Flagella KW - Human diseases KW - Laboratory animals KW - monoclonal antibodies KW - Proteins KW - USA KW - Acari KW - Arachnida KW - Argasidae KW - Borrelia hermsii KW - Man KW - Mice KW - Ornithodoros hermsi KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Metastigmata KW - Acari KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Muridae KW - rodents KW - Ornithodoros KW - Argasidae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - bacterium KW - immunogens KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515850&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis. AU - Marconi, R. T. AU - Garon, C. F. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1992/// VL - 30 IS - 11 SP - 2830 EP - 2834 SN - 0095-1137 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, Department of Health and Human Services, Hamilton, MT 59840, USA. N1 - Accession Number: 19930518654. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology N2 - Partial 16S rRNA sequences from 23 Lyme disease spirochaete isolates were determined and compared, and aligned with 8 sequences previously presented. The 16S rRNA signature nucleotide compositions were defined for each isolate and compared with the genomic species signature nucleotide sets previously established. To identify positions truly indicative of species classification which could serve as targets for polymerase chain reaction (PCR) species-specific identification primers, 16S rRNA-based phylogenetic analyses were conducted. On the basis of the identified signature nucleotides, PCR primer sets were designed which amplified all spirochaete species associated with Lyme disease and differentiated between these species. The primer sets were tested on 38 Borrelia isolates associated with Lyme disease and were found to be sensitive and specific. All Lyme disease isolates tested were amplification positive. These primers allowed for the rapid species identification of Lyme disease isolates. KW - Diagnosis KW - Diagnostic techniques KW - identification KW - Lyme disease KW - Nucleotide sequences KW - polymerase chain reaction KW - RNA KW - France KW - Germany KW - Japan KW - Russia KW - Sweden KW - Switzerland KW - USA KW - Borrelia burgdorferi KW - Borrelia garinii KW - Man KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Western Europe KW - Europe KW - APEC countries KW - East Asia KW - Asia KW - Scandinavia KW - Northern Europe KW - EFTA KW - North America KW - America KW - bacterium KW - DNA sequences KW - lyme borreliosis KW - PCR KW - ribonucleic acid KW - Russian Federation KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518654&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - DNA probe for strain typing of Cryptococcus neoformans. AU - Varma, A. AU - Kwon-Chung, K. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1992/// VL - 30 IS - 11 SP - 2960 EP - 2967 SN - 0095-1137 AD - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921213188. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A 7-kb linear plasmid, harboured by a URA5 transformant, hybridized to all the chromosomes of C. neoformans separated by contour-clamped homogeneous electric field electrophoresis. Its linear maintenance was determined to have been facilitated by the presence of telomere-like sequences at its free ends. Hybridization of this plasmid to AccI-digested genomic DNAs of 26 C. neoformans strains generated 21 unique DNA fingerprints. The DNA fingerprints of isolates within the same serotype were more similar to one another than to those from different serotypes. An acapsular clinical isolate, strain 602, widely used in immunological studies and previously thought to be in serotype D, showed DNA fingerprints typical of serotype A isolates. Isogenic strains of C. neoformans exhibited DNA fingerprints that were identical to one another. The DNA fingerprints were stable and reproducible in spite of repeated transfers in the laboratory on either complex (1% yeast extract, 2% Bacto Peptone, 2% glucose) or minimal (yeast nitrogen base) medium. The DNA fingerprints of isolates recovered from primary blood and cerebrospinal fluid cultures of patients for whom AIDS had been diagnosed showed that the original infection in each of these patients contained a homogeneous population of C. neoformans. The DNA fingerprints of isolates recovered from different tissues of infected mice and from patients undergoing different drug therapy regimens were also found to be very stable. KW - DNA fingerprinting KW - genetics KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921213188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aspergillus quadrilineatus, a new causative agent of fungal sinusitis. AU - Polacheck, I. AU - Nagler, A. AU - Okon, E. AU - Drakos, P. AU - Plaskowitz, J. AU - Kwon-Chung, K. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1992/// VL - 30 IS - 12 SP - 3290 EP - 3293 SN - 0095-1137 AD - Polacheck, I.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921213463. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case of A. quadrilineatus pansinusitis is reported in a 28-yr-old woman in Israel with acute non-lymphoblastic leukaemia, who had undergone allogeneic bone marrow transplantation. A. quadrilineatus was cultured from biopsy specimens of the maxillary sinus and tissue sections with fungal stains showed a necrotic area containing dichotomously branching septate hyphae, morphologically consistent with Aspergillus spp. The patient was successfully treated with a combination of surgical debridement, granulocyte transfusions and intravenous administration of amphotericin B-cholesterol sulfate colloidal dispersion (total dose 6.5 g). KW - hosts KW - infections KW - sinuses KW - Israel KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - Developed Countries KW - Mediterranean Region KW - Middle East KW - West Asia KW - Asia KW - Aspergillus quadrilineatus KW - fungus KW - Hyphomycetes KW - mitosporic fungi KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921213463&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunomodulation and antifungal therapy of experimental invasive candidosis, histoplasmosis and aspergillosis: recent advances and concepts. AU - Walsh, T. J. AU - Cutsem, J. van AU - Polak, A. M. AU - Graybill, J. R. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1992/// VL - 30 IS - Suppl. 1 SP - 225 EP - 240 SN - 0268-1218 AD - Walsh, T. J.: Section of Infectious Diseases, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201448. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 53 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Concepts of pathogenesis and immunomodulation in experimental infections caused by Candida spp., Aspergillus spp. and Histoplasma capsulatum and treatment of these infections with single antifungal agents or combinations are reviewed. KW - antifungal agents KW - aspergillosis KW - candidosis KW - drug therapy KW - experimental infections KW - histoplasmosis KW - immunology KW - immunotherapy KW - pathogenesis KW - therapy KW - Aspergillus KW - Candida KW - Histoplasma capsulatum KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Histoplasma KW - Ajellomyces capsulatus KW - candidiasis KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - XI Congress of the International Society for Human and Animal Mycology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Five-year plan for nutrition research and training: executive summary. JO - Pediatric Research JF - Pediatric Research Y1 - 1992/// VL - 32 IS - 1 SP - 1 EP - 9 SN - 0031-3998 AD - Office of Research Reporting, National Institute of Child Health and Human Development, Building 31, Room 2A32, Bethesda, MD 20892, USA. N1 - Accession Number: 19931460258. Publication Type: Journal Article. Corporate Author: USA, National Institute of Child Health and Human Development Language: English. Subject Subsets: Human Nutrition N2 - A summary of the recommendations of a meeting of the Endocrinology, Nutrition and Growth branch of the National Institute of Child Health and Human Development is presented. KW - Children KW - guidelines KW - Infants KW - nutrition research KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - recommendations KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460258&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease. AU - Kárpáti, S. AU - Meurer, M. AU - Stolz, W. AU - Bürgin-Wolff, A. AU - Braun-Falco, O. AU - Krieg, T. JO - Gut JF - Gut Y1 - 1992/// VL - 33 IS - 2 SP - 191 EP - 193 SN - 0017-5749 AD - Kárpáti, S.: Building 10, R12N242, National Institutes of Health, Dermatology Branch of the National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931458184. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition N2 - The ultrastructural binding sites of endomysium antibodies, specific serological markers of gluten sensitive enteropathy, were investigated in the rabbit oesophagus using the immunogold technique. Endomysium antibodies from sera of patients with dermatitis herpetiformis and with coeliac disease bound in an identical manner in a non-fibrillar material closely associated with fine collagenous-reticulin fibrils and also with similar fibrils connecting smooth muscle cells and elastic tissue in the endomysial connective tissue. These observations suggest that IgA antibodies in sera from patients with dermatitis herpetiformis and coeliac disease recognise a common antigen in an amorphous component associated with the reticular connective tissue of oesophageal lamina muscularis mucosae and thus confirm the probable identity of IgA class endomysium and jejunal antibodies. KW - antibodies KW - binding sites KW - Coeliac syndrome KW - Dermatitis herpetiformis KW - IgA KW - in vitro KW - Jejunum KW - Oesophagus KW - small intestine KW - Man KW - Rabbits KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - binding site KW - celiac disease KW - celiac syndrome KW - coeliac disease KW - esophagus KW - gluten allergy KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931458184&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transport of n-3 fatty acids from the intestine to the retina in rats. AU - Li, J. AU - Wetzel, M. G. AU - O'Brien, P. J. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1992/// VL - 33 IS - 4 SP - 539 EP - 548 SN - 0022-2275 AD - Li, J.: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, MD, USA. N1 - Accession Number: 19941408547. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 25167-62-8, 463-40-1. Subject Subsets: Human Nutrition; Animal Nutrition N2 - This study was undertaken to examine the mode of transport of docosahexaenoic acid C22:6(n-3) and linolenic acid C18:3(n-3). Male weanling Sprague-Dawley rats received a mixture of maize oil and [14C]18:3(n-3) or [14C]22:6(n-3) by gavage. At periods of 1 to 4 days after the injection, 4 rats per time point were killed and samples of blood were taken via heart puncture and the livers and retinas were collected. Blood lipoproteins and plasma proteins were separated by ultracentrifugation and analysed by HPLC. Lipids were extracted and saponified and the fatty acids were converted to phenacyl esters for separation of individual fatty acids. After 1 and 2 h, radioactivity from C18:3(n-3) and C22:6(n-3) was observed primarily in the chylomicron/VLDL fraction. By 4 h, radioactivity in the lipoprotein fraction was greatly decreased, with a small amount of radioactivity associated with albumin in the soluble protein fraction. After 24 h, the total amount of radioactivity associated with lipoprotein was further reduced, with more than half of the remaining label occurring in association with albumin and another unidentified protein. In the liver, C22:6(n-3) was concentrated in triacylglycerols (40.7%) and phospholipids (51.1%), with a maximum specific activity at 4 h. In the rod outer segments (ROS), the specific activity of [14C]22:6(n-3) increased to a maximum at 24 h and maintained a high value even at 4 days. These data suggest that after injection, C18:3(n-3) and C22:6(n-3) are esterified to triglyceride and phospholipid by the intestinal absorptive cells and transported in chylomicrons to the liver. After conversion of C18:3(n-3) to C22:6(n-3) in the liver, the retina accumulates C22:6(n-3) which may be transported from the liver via albumin and another unidentified protein, and is retained by the rod outer segments. KW - chylomicron lipids KW - docosahexaenoic acid KW - fatty acids KW - intestines KW - linolenic acid KW - metabolism KW - retina KW - serum albumin KW - transport KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chylomicrons KW - transportation KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii induction of tumor necrosis factor-α by alveolar macrophages: modulation by pentamidine isethionate. AU - Corsini, E. AU - Dykstra, C. AU - Craig, W. A. AU - Tidwell, R. R. AU - Rosenthal, G. J. JO - Immunology Letters JF - Immunology Letters Y1 - 1992/// VL - 34 IS - 3 SP - 303 EP - 308 SN - 0165-2478 AD - Corsini, E.: Immunotoxicology Section, Division of Toxicology Research and Testing, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19950802517. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9008-11-1, 100-33-4, 140-64-7, 308079-78-9. Subject Subsets: Protozoology N2 - Pneumocystis carinii cysts were found to be capable of inducing tumour necrosis factor-α (TNF) release from alveolar macrophages in rats, in a concentration-dependent manner. Pentamidine isethionate (pentamidine) reduced this TNF production dose-dependently to over 50% at physiologically achievable concentrations (0.01-10.00 µM). Pretreatment of alveolar macrophages with interferon-γ (IFN-γ) synergized with P. carinii to produce increased levels of TNF. Pentamidine treatment antagonized this condition but did not interfere with the phagocytic ability of the macrophages. It is possible that anti-inflammatory properties of inhaled pentamidine can reduce the detrimental effects associated with the overproduction of TNF in the lower lung. Suppression of inflammatory mediators such as TNF, together with a direct effect of pentamidine on P. carinii, may be a critical factor in the efficacy of the drug. KW - drug therapy KW - immune response KW - immunocompromised hosts KW - interferon KW - laboratory mammals KW - opportunistic infections KW - parasites KW - pentamidine KW - tumour necrosis factor KW - Muridae KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - rats KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - Muridae KW - cachectin KW - cachexin KW - chemotherapy KW - fungus KW - immunity reactions KW - immunological reactions KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NIAID [National Institute of Allergy and Infectious Diseases] tropical disease research: priorities and future directions. AU - Western, K. A. JO - Tropical Medicine (Nagasaki) JF - Tropical Medicine (Nagasaki) Y1 - 1992/// VL - 34 IS - 4 SP - 157 EP - 163 SN - 0385-5643 AD - Western, K. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940801385. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 14 ref. Subject Subsets: Helminthology; Protozoology KW - helminths KW - parasites KW - research KW - teaching KW - tropical medicine KW - Maryland KW - North America KW - USA KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - instruction KW - parasitic worms KW - studies KW - United States of America KW - Research (AA500) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801385&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The origin of plagues: a research agenda for the 21st Century. AU - Krause, R. M. JO - Tropical Medicine (Nagasaki) JF - Tropical Medicine (Nagasaki) Y1 - 1992/// VL - 34 IS - 4 SP - 165 EP - 170 SN - 0385-5643 AD - Krause, R. M.: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19940801386. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Subject Subsets: Protozoology KW - control KW - human diseases KW - parasites KW - teaching KW - tropical medicine KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - discussed KW - instruction KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801386&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. AU - Kashman, Y. AU - Gustafson, K. R. AU - Fuller, R. W. AU - Cardellina, J. H., II AU - McMahon, J. B. AU - Currens, M. J. AU - Buckheit, R. W., Jr. AU - Hughes, S. H. AU - Cragg, G. M. AU - Boyd, M. R. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1992/// VL - 35 IS - 15 SP - 2735 EP - 2743 SN - 0022-2623 AD - Kashman, Y.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19940600764. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Horticultural Science; Forestry; Forest Products N2 - Eight new coumarin compounds were isolated by anti-HIV bioassay-guided fractionation of an extract of fruits and twigs of Calophyllum lanigerum from Sarawak, Malaysia. The chemistry and biological activity of each compound are described. Calanolides A and B were completely protective against HIV-1 replication and cytopathicity, but were inactive against HIV-2. Some of the related compounds also showed evidence of anti-HIV-1 activity. The calanolides were specific HIV-1 reverse transcriptase inhibitors; calanolide A was active against both the AZT-resistant G-9106 strain of HIV-1 and the pyridone-resistant A17 strain. KW - broadleaves KW - coumarins KW - medicinal plants KW - medicinal properties KW - trees KW - woody plants KW - Malaysia KW - Sarawak KW - plants KW - eukaryotes KW - Calophyllum KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - APEC countries KW - ASEAN Countries KW - Commonwealth of Nations KW - Developing Countries KW - South East Asia KW - Asia KW - Threshold Countries KW - Borneo KW - Malaysia KW - Calophyllum lanigerum KW - drug plants KW - medicinal herbs KW - officinal plants KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Non-wood Forest Products (KK540) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940600764&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low bias in assayed values of lipoprotein antigens-lipoprotein(a) and apolipoprotein A-1 and B-in midday postprandial blood specimens compared with morning fasting specimens. AU - Emancipator, K. JO - Clinical Chemistry JF - Clinical Chemistry Y1 - 1992/// VL - 38 IS - 3 SP - 431 EP - 433 SN - 0009-9147 AD - Emancipator, K.: Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931465098. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition N2 - 2-h postprandial specimens had a -14% proportional bias for lipoprotein(a) (Lp(a)), a -0.035 g/litre systematic bias for apolipoprotein (apo) A-1, and a -9% proportional bias for apo B, compared with values in 12-h fasting specimens. Although a physiological haemodilution appears to account for a proportion of these biases, other major factors must be implicated for Lp(a) and apo B. Even after dilutional effects are controlled for, assayed values of Lp(a) were 11-13% lower, and assayed values of apo B were 8-9% lower, in postprandial specimens than in fasting specimens. Therefore, the time of collection of blood sample relative to the last meal can significantly affect assayed values of lipoprotein antigens. KW - Analytical methods KW - Apolipoproteins KW - assays KW - blood KW - fasting KW - food intake KW - Lipoproteins KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - Techniques and Methodology (ZZ900) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465098&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stereo views and immunogold labeling of the pellicular microtubules at the inner surface of the plasma membrane of Leishmania as revealed by fracture-flip. AU - Hou, W. Y. AU - Pimenta, P. F. P. AU - Ru-Long, S. AU - Silva, P. P. da JO - Journal of Histochemistry and Cytochemistry JF - Journal of Histochemistry and Cytochemistry Y1 - 1992/// VL - 40 IS - 9 SP - 1309 EP - 1318 SN - 0022-1554 AD - Hou, W. Y.: Structural Biology Section, Laboratory of Mathematical Biology (W-YH, SR-L,PPS), National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19930802332. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - A modification of fracture-flip was used to reveal the nanoanatomy of the inner surface of the plasma membrane in promastigotes of Leishmania major. After freeze-fracture, lightly fixed promastigotes were coated with a stabilizing layer of carbon evaporated from an electron gun, thawed, and washed. Fractured promastigotes attached to the carbon casts by the protoplasmic (i.e., inner) halves of their plasma membranes were treated with Triton X-100, followed by exposure to low concentrations of trypsin and thorough washing. This was followed by picking up and flipping of the replicas, followed by air-drying. The actual inner surfaces of the plasma membrane were then imaged by platinum shadowing. Extended, 3-dimensional, high-resolution views of the inner surface of the plasma membrane showed parallel arrays of microtubules (average spacing 47 nm) closely apposed to the inner surface. Cytochemical labelling confirmed the morphological identification of both subpellicular and flagellar microtubules, as determined by treatment with mouse monoclonal anti-α- or anti-β-tubulin, followed by labelling with goat anti-mouse IgG absorbed to colloidal gold. Removal of the microtubules revealed parallel arrays of particles (average diameter 17 nm). It is hypothesized that these particles represent the cytoplasmic portion of proteins that link the microtubules to the plasma membrane. KW - Human diseases KW - microtubules KW - parasites KW - Plasma membranes KW - ultrastructure KW - Leishmania major KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cell membrane KW - plasmalemma KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802332&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetically obese rats with (SHR/N-cp) and without diabetes (LA/N-cp) share abnormal islet responses to glucose. AU - Timmers, K. I. AU - Voyles, N. R. AU - Recant, L. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1992/// VL - 41 IS - 10 SP - 1125 EP - 1133 SN - 0026-0495 AD - Timmers, K. I.: Building 10, Room 5N102, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402232. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition N2 - To assess the effect of hyperglycaemia on the function of islets obtained from obese rats, the behaviour of isolated islets from LA/N-corpulent (non-diabetic obese) and SHR/N-corpulent (diabetic obese) male rats was examined and compared. Islets from both genetic models showed a left-shifted glucose dose-response curve for insulin release (concentrations for half-maximal release, 5 to 6 vs. 12 to 13 mmol/litre in LA/N lean littermates and 3 vs. 10 mmol/litre in lean SHR/N). When insulin release was expressed per unit islet volume, the 4- to 5-fold enlarged islets from obese diabetic and obese non-diabetic rats showed decreased insulin secretory response in high (16.5 to 28 mmol/litre) glucose concentrations, although the decrease was more severe in the diabetic rats. Glucose-stimulated insulin release by islets from both models was relatively resistant to inhibition by mannoheptulose 1.2 mmol/litre (e.g., 82±3% inhibition in LA/N lean vs. 16±8% in LA/N obese), although nearly complete inhibition was observed with mannoheptulose 16 mmol/litre (96 vs. 85%, not significant). Islets of obese diabetic rats were also resistant to the calcium-channel blocker, verapamil, suggesting an abnormal pathway of stimulus-secretion coupling for glucose. Glucose oxidation to carbon dioxide was increased in both obese models at all glucose concentrations when expressed per islet. In data express per unit volume, the larger islets from the obese-nondiabetic rats showed a left-shifted dose-response curve with an unchanged maximum rate of glucose oxidation at high (16.5 mmol/litre) glucose concentrations. Reduced immunoreactive glucose transporter protein (Glut-2) was found in nondiabetic- and diabetic-obese islets. The data demonstrate that many of the islet lesions associated with high plasma glucose concentrations also can arise in genetic obesity in the absence of sustained hyperglycaemia. KW - diabetes KW - glucose KW - glucose tolerance KW - hyperglycaemia KW - in vitro KW - insulin secretion KW - obesity KW - pancreas islets KW - responses KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood sugar tolerance KW - dextrose KW - fatness KW - high blood glucose KW - hyperglycemia KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Animal Models of Human Nutrition (VV140) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP syndrome). AU - Higgins, J. J. AU - Patterson, M. C. AU - Papadopoulos, N. M. AU - Brady, R. O. AU - Pentchev, P. G. AU - Barton, N. W. JO - Neurology JF - Neurology Y1 - 1992/// VL - 42 IS - 1 SP - 194 EP - 198 SN - 0028-3878 AD - Higgins, J. J.: Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892, USA. N1 - Accession Number: 19931464125. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Clinical and laboratory studies of an 11-year-old girl with prominent orofacial dyskinesia, dystonia and progressive dementia are described. Investigations revealed hypoprebetalipoproteinaemia, acanthocytosis, atypical retinitis pigmentosa and evidence of iron deposition in the pallidal nuclei. Electroneuromyography and skin and sural nerve biopsies were normal. The "eye-of-the-tiger" sign, used to described the pallidal nuclei in Hallervorden-Spatz syndrome, was present on T2-weighted magnetic resonance images. Phase-contrast microscopy of whole blood showed 80-90% acanthocytes whose morphology was confirmed by electron microscopy. High-resolution lipoprotein electrophoresis demonstrated an absence of the pre-beta fraction. This case differs phenotypically from previous reports of Hallervorden-Spatz disease with acanthocytosis by the presence of prominent orofacial dyskinesia and abnormal serum lipoproteins. KW - case reports KW - Children KW - hypolipoproteinaemia KW - nervous system diseases KW - Retinitis pigmentosa KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypolipoproteinemia KW - neuropathy KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum albumin in older persons: relationship with age and health status. AU - Salive, M. E. AU - Cornoni-Huntley, J. AU - Phillips, C. L. AU - Guralnik, J. M. AU - Cohen, H. J. AU - Ostfeld, A. M. AU - Wallace, R. B. JO - Journal of Clinical Epidemiology JF - Journal of Clinical Epidemiology Y1 - 1992/// VL - 45 IS - 3 SP - 213 EP - 221 SN - 0895-4356 AD - Salive, M. E.: Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Gateway Building, Suite 3C309, Bethesda, MD 20892, USA. N1 - Accession Number: 19931468236. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Data was analysed from 4115 persons, 71 years old, who had blood drawn at a home visit in 3 communities, to examine the cross-sectional distribution of serum albumin and correlates of hypoalbuminaemia. Mean albumin was lower among older persons from 41.6 in men 71-74 years old to 38.5 g/litre in men ≥90 years old, and from 41.1 to 38.9 g/litre in women of the same ages, respectively. Hypoalbuminaemia (albumin <35 g/litre) was observed in 3.1% of subjects. Hypoalbuminaemia and lower serum albumin were independently associated with anaemia, recent diagnosis of cancer, 2 or more limitations in activities of daily living, residence in a nursing home, heavy cigarette smoking (>1 pack/day), and older age. A 10-year age increment was associated with 0.8 g/litre lower serum albumin and odds ratio of 1.56 (95% CI 1.14, 2.13) for hypoalbuminaemia after adjusting for demographic factors and health status. Characteristics associated with serum albumin may confound the reported relation between serum albumin and mortality. KW - age KW - Anaemia KW - Carcinoma KW - health KW - Hypoalbuminaemia KW - Old age KW - serum albumin KW - Tobacco smoking KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anemia KW - hypoalbuminemia KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468236&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spotted fever rickettsiae in ticks from the northern Sinai Governorate, Egypt. AU - Lange, J. V. AU - El-Dessouky, A. G. AU - Manor, E. AU - Merdan, A. I. AU - Azad, A. F. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1992/// VL - 46 IS - 5 SP - 546 EP - 551 SN - 0002-9637 AD - Lange, J. V.: Office of Tropical Medicine and International Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building CDB-3C25, 6003 Executive Boulevard, Bethesda, MD 20892, USA. N1 - Accession Number: 19920510808. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - A field study was initiated in 1988 to investigate whether spotted fever group rickettsiae occur in geographic areas in Egypt that are adjacent to an area in the southern Israeli Negev that has a defined focus of spotted fever disease. Ticks were collected in June-September 1988 and 1989 from dogs, sheep and camels at 4 study sites in the northern Sinai. Tick haemolymph was processed for rickettsial detection by staining with fluorescein isothiocyanate-conjugated antibody to Rickettsia rickettsii. Of the 442 haemolymph samples examined, 15 contained immunofluorescent rickettsiae. 8 Rhipicephalus sanguineus removed from dogs were haemolymph test-positive (HT+); the other HT+ ticks comprised 3 Hyalomma species, H. anatolicum, H. impeltatum and H. dromedarii. Both HT+ and HT- ticks were tested for rickettsial DNA using the polymerase chain reaction (PCR). 8 of 10 HT+ field-collected ticks were PCR positive (PCR+). All laboratory colony R. rickettsii-infected ticks were PCR+. No HT- ticks from field or laboratory isolates were PCR+.<new para>ADDITIONAL ABSTRACT:<new para>A field study was initiated in 1988 to investigate whether spotted fever group rickettsiae occur in geographic areas in Egypt that are adjacent to an area in the southern Israeli Negev that has a defined focus of spotted fever disease. Ticks were collected from dogs, sheep, and camels at four study sites in the northern Sinai. Tick hemolymph was processed for rickettsial detection by staining with fluorescein isothiocyanate-conjugated antibody to Rickettsia rickettsii. Of the 442 hemolymphs examined, 15 contained immunofluorescent rickettsiae. Eight hemolymph test-positive (HT+) ticks were Rhipicephalus sanguineus removed from dogs; the other HT+ ticks comprised three Hyalomma species, H. anatolicum, H. impeltatum, and H. dromedarii. Both HT+ and HT- ticks were tested for rickettsial DNA using the polymerase chain reaction (PCR). Eight of 10 HT+ field-collected ticks were PCR positive (PCR+). All laboratory colony R. rickettsii-infected ticks were PCR+. No HT- ticks from field or laboratory isolates were PCR+.AS KW - Disease vectors KW - Polymerase chain reaction KW - rickettsial diseases KW - Zoonoses KW - Africa KW - Asia KW - Egypt KW - Middle East KW - North Africa KW - Acari KW - Arachnida KW - Camelus KW - Dogs KW - Dromedaries KW - Goats KW - Hyalomma anatolicum KW - Hyalomma dromedarii KW - Hyalomma impeltatum KW - Ixodidae KW - Metastigmata KW - Rhipicephalus sanguineus KW - Rickettsia KW - Rickettsia rickettsii KW - Rickettsiaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Camelidae KW - Tylopoda KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - Camelus KW - Capra KW - Bovidae KW - ruminants KW - Hyalomma KW - Ixodidae KW - Metastigmata KW - Acari KW - Rhipicephalus KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - West Asia KW - Asia KW - bacterium KW - camels KW - Camelus dromedarius KW - Misr KW - Near East KW - northern Sinai KW - PCR KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920510808&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Persistence of eggs and hepatic fibrosis after treatment of Schistosoma mansoni-infected mice. AU - Cheever, A. W. AU - Macedonia, J. G. AU - Deb, S. AU - Cheever, E. A. AU - Mosimann, J. E. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1992/// VL - 46 IS - 6 SP - 752 EP - 758 SN - 0002-9637 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19920800904. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 26328-53-0, 55268-74-1, 15489-16-4. Subject Subsets: Helminthology; Tropical Diseases N2 - In 1971 it was estimated that S. mansoni eggs in the tissues of mice were destroyed with an approximate half-life of 4 weeks. The present results of 5 experiments using BALB/cAnN and C57B1/6CR mice suggest that egg destruction is not as rapid, and no significant destruction of eggs was detected for up to 26 weeks after treatment with either praziquantel, amoscanate or stibophen. However, in these experiments, a mean of 60% of the eggs in intestinal tissues were found in the faeces at the time of treatment. In previously reported experiments only 15% of gut eggs were passed in the faeces. It is now believed that underestimation of the number of eggs passed in the faeces led to an overestimation of the number of eggs destroyed in the tissues. The liver eggs were analyzed separately because eggs lost from this site are unaffected by eggs passed in the faeces. No significant decrease in liver eggs occurred in the present experiments, but reanalysis of previously published data showed significant egg destruction in the liver in several experiments, although at a much slower rate than previously estimated. However, inspection of the data in the previously published and present experiments does not show a convincing difference in the number of eggs in the liver after treatment. The persistence of egg shells is probably not important in the pathogenesis of disease, but is of concern in calculating worm fecundity. Hepatic collagen levels increased markedly 2 weeks after treatment and subsequently decreased significantly in some, but not all, experiments.<new para>ADDITIONAL ABSTRACT:<new para>The authors report that they could detect no significant destruction of Schistosoma mansoni eggs in the tissues of mice for up to 26 weeks after their chemotherapeutic cure 7-8 weeks after infection. This result contrasts with a previous estimate from this group of a half-life for tissue eggs of about 4 weeks in treated mice [see Trop. Dis. Bull., 1972, 69, abst. 56]. The experimental reasons for the different results are explored.Carolyn A. Brown KW - Amoscanate KW - drug therapy KW - helminths KW - Human diseases KW - Laboratory animals KW - Liver KW - Ova KW - parasites KW - Praziquantel KW - schistosomiasis KW - Stibophen KW - treatment KW - Digenea KW - mice KW - Muridae KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - chemotherapy KW - egg persistence KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma concentrations of glucose, insulin, and percent glycosylated hemoglobin are unaltered by food restriction in Rhesus and Squirrel monkeys. AU - Cutler, R. G. AU - Davis, B. J. AU - Ingram, D. K. AU - Roth, G. S. JO - Journal of Gerontology JF - Journal of Gerontology Y1 - 1992/// VL - 47 IS - 1 SP - B9 EP - B12 SN - 0022-1422 AD - Cutler, R. G.: G. S. Roth, Gerontology Research Center, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224, USA. N1 - Accession Number: 19931465125. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Plasma concentrations of glucose and percentage of glycosylated haemoglobin have been reported to be reduced in food-restricted rats when compared with freely fed controls [Masoro et al., Journal of Gerontology (1989) 44, B20-B22]. In a similar experiment in primates, plasma insulin was also estimated. Rhesus and squirrel monkeys were fed freely 30% less than weight-matched controls for up to 36 months. No significant age or diet effects on plasma concentration of glucose, insulin or percentage glycosylated haemoglobin were observed, except that glucose values and the percentage of glycosylated haemoglobin could be established within any group of monkeys. The results suggest possible differences in glucose-related metabolism in freely fed and food-restricted primates compared with observations made in rats. KW - blood KW - Blood sugar KW - food restriction KW - Haemoglobin KW - Insulin KW - Macaca mulatta KW - monkeys KW - Saimiri KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Cebidae KW - blood glucose KW - glucose in blood KW - glycosylation KW - hemoglobin KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea. AU - Gustafson, K. R. AU - Blunt, J. W. AU - Munro, M. H. G. AU - Fuller, R. W. AU - McKee, T. C. AU - Cardellina, J. H., II AU - McMahon, J. B. AU - Cragg, G. M. AU - Boyd, M. R. JO - Tetrahedron JF - Tetrahedron Y1 - 1992/// VL - 48 IS - 46 SP - 10093 EP - 10102 SN - 0040-4020 AD - Gustafson, K. R.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19940308232. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Forestry N2 - Seven new polyisoprenylated benzophenone derivatives and/or related benzophenone derivatives were isolated from members of the Guttiferae family: guttiferones A-D from the roots of Symphonia globulifera, and guttiferone E and isoxanthochymol from the leaves of Garcinia ovalifolia (samples of both species collected from the Central African Republic, in March 1988); guttiferone A from the fruits of G. livingstonei (collected from Tanzania, in Dec. 1988); and guttiferone E and xanthochymol from the leaves of Clusia rosea (collected from the Dominican Republic). The chemical structures of these compounds were elucidated from spectral analyses. All compounds except for isoxanthochymol inhibited the cytopathic effects of in vitro HIV infection in human lymphoblastoid CEM-SS cells (EC50 values of 1-10 μg/ml). Cytotoxicity occurred at concentrations above 50 μg/ml. There was no indication of a corresponding decrease in indices of viral replication. KW - antiviral plants KW - antiviral properties KW - chemical composition KW - foliage KW - forest trees KW - fruits KW - human immunodeficiency viruses KW - ketones KW - leaves KW - medicinal plants KW - plant composition KW - roots KW - sesquiterpenoids KW - spectral analysis KW - trees KW - woody plants KW - Central African Republic KW - Dominican Republic KW - Tanzania KW - Clusiaceae KW - Garcinia KW - plants KW - Symphonia globulifera KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Clusiaceae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Symphonia KW - Clusia KW - Garcinia KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - Hispaniola KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - Threshold Countries KW - Anglophone Africa KW - Commonwealth of Nations KW - East Africa KW - SADC Countries KW - anti-viral properties KW - benzophenones KW - chemical constituents of plants KW - chemical structures KW - Clusia rosea KW - drug plants KW - Garcinia livingstonei KW - Garcinia ovalifolia KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Tanganyika KW - Plant Composition (FF040) KW - Pesticides and Drugs (General) (HH400) KW - Non-wood Forest Products (KK540) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Silviculture and Forest Management (KK110) KW - Forests and Forest Trees (Biology and Ecology) (KK100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940308232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Two types of sequence polymorphism in the circumsporozoite gene of Plasmodium falciparum. AU - McCutchan, T. F. AU - Lal, A. A. AU - Rosario, V. do AU - Waters, A. P. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 50 IS - 1 SP - 37 EP - 45 SN - 0166-6851 AD - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19920877162. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology N2 - Two characteristically different classes or types of gene sequence variation in the circumsporozoite protein from P. falciparum were demonstrated. Some patterns of sequence variation suggest, or are at least consistent with, Mendelian inheritance. The patterns of sequence variation at specific positions, introduced homoplasy (similarity or identity not directly attributable to common ancestry) into the relationship between parasites. The demonstration of extensive homoplasy in a malaria gene raises questions about the validity of familial relationships established among parasites with polymorphic markers. It is suggested that homoplasy at particular positions could mark a site of biological pressure on the parasite where interaction of the site with factors in the environment affects the success of the parasite population. The circumsporozoite protein in malarial vaccine constructs is discussed. An approach to structural analysis that demonstrates and quantitates the degree of homoplasy in particular positions of a protein is described. KW - circumsporozoite protein KW - Genes KW - Genetics KW - Human diseases KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877162&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a Giardia lamblia variant-specific surface protein (VSP) gene from isolate GS/M and estimation of the VSP gene repertoire size. AU - Nash, T. E. AU - Mowatt, M. R. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 51 IS - 2 SP - 219 EP - 227 SN - 0166-6851 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878382. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 52-90-4. Subject Subsets: Protozoology; Tropical Diseases N2 - Giardia lamblia undergoes surface antigenic variation. The variant-specific surface proteins (VSPs) of isolate WB are cysteine-rich, can vary dramatically in size, contain Cys-X-X-Cys motifs, and are differentially expressed. GS/M(H7) is a Giardia clone from a different isolate which expresses a VSP epitope not found in WB. The VSP gene encoding this epitope was selected by differential hybridization using radiolabelled cDNA from H7 and variant sibling trophozoite lines from the same isolate that express other VSPs. The VSPH7 gene probe detects an 1800 nucleotide transcript abundant in H7 but undetectable in variant siblings. Primer extension directly from RNA was used to complete the gene sequence which predicted a protein with a MW of 56 832. The protein showed many of the characteristics of 2 previously sequenced WB VSPs including many Cys-X-X-Cys tetrapeptides and a conserved carboxy-terminal region. Genomic Southern analysis indicated the presence of 2 distinct VSPH7 genes in H7. An oligonucleotide from the conserved region was used in combination with one specific for the VSPH7 gene to estimate the VSP repertoire size at between 133 and 151. VSPs, even from isolates expressing unique epitopes, constitute a family of related proteins. KW - Antigenic variation KW - antigens KW - Cysteine KW - Genes KW - Human diseases KW - Nucleotide sequences KW - parasites KW - Proteins KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - DNA sequences KW - GIARDIA LAMBLIA KW - immunogens KW - variant-specific surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An RFLP map of the Plasmodium falciparum genome, recombination rates and favored linkage groups in a genetic cross. AU - Walker-Jonah, A. AU - Dolan, S. A. AU - Gwadz, R. W. AU - Panton, L. J. AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 51 IS - 2 SP - 313 EP - 320 SN - 0166-6851 AD - Walker-Jonah, A.: T.E. Wellems, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878391. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A genetic linkage map of the P. falciparum genome is reported, using the inheritance patterns of nearly 90 restriction fragment length polymorphism markers in a genetic cross. Markers were assigned to polymorphic loci on all 14 nuclear chromosomes. Genetic recombination between parental markers was detected in each of the progeny, indicating that progeny from cross-fertilization events were favoured over progeny from self-fertilization of either parent alone. Inheritance patterns among the markers suggested that certain parental linkage groups on chromosomes 2, 3, 12 and 13 were favoured in the cross. Recombination frequencies on 5 chromosomes indicated an approximate map unit size of 15-30 kb per centiMorgan for P. falciparum. KW - Gene mapping KW - genomes KW - Human diseases KW - Molecular genetics KW - parasites KW - restriction fragment length polymorphism KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - genetic linkage map KW - RFLP KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878391&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aflatoxin-transformed C3H/10T1/2 cells overexpress protein kinase C and have an altered response to phorbol ester treatments. AU - Dunn, J. A. AU - Faletto, M. B. AU - Kasper, S. J. AU - Gurtoo, H. L. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 IS - 4 SP - 990 EP - 996 SN - 0008-5472 AD - Dunn, J. A.: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19921211328. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The aflatoxin B1-transformed C3H/10T1/2 (10T1/2) cell line 7SA has disordered growth in culture and is tumorigenic in syngeneic mice. Chronic exposure (14 d) of 10T1/2 and 7SA cells to phorbol 12,13-dibutyrate (PDBu) increased the saturation density of 10T1/2 cells but dramatically slowed the entry of 7SA cells into the log phase of growth without affecting their final saturation density, Similar PDBu treatment of low-density cultures dramatically decreased the size of 7SA colonies. Both cell lines bound [³H]PDBu in a specific and saturable manner. Analysis of this binding yielded linear Scatchard plots for both cell lines with distinctly different Kd values (10.7 nM for 10T1/2 vs. 54.5 nM for 7SA). The total amount of [³H]PDBu bound was 2-fold greater in the 7SA cells vs. the 10T1/2 cell line. Both cell lines released arachidonic acid following a 2-h exposure to PDBu; however, the magnitude of the response of the 7SA cells was only 50% that of the 10T1/2 cells. Western blot analysis of protein kinase C (PKC) using specific anti-PKC antibodies revealed a greater total amount of PKCα in the 7SA cells relative to an equal number of 10T1/2 cells. No immunoreactive PKCα was found in either cell line 16 h after exposure to 600 nM PDBu; however, PKCα returned to control levels in both cell lines 24 h after removal of the phorbol ester. It is suggested that an overexpression of PKCα may play a role in the altered biological properties of aflatoxin-transformed 10T1/2 cells. KW - Aflatoxins KW - carcinogenesis KW - Mycotoxins KW - toxicity KW - fungal toxins KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211328&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates. AU - Fujimoto, Y. AU - Hampton, L. L. AU - Luo, L. AU - Wirth, P. J. AU - Thorgeirsson, S. S. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 IS - 4 SP - 1044 EP - 1046 SN - 0008-5472 AD - Fujimoto, Y.: S. S. Thorgeirsson, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211329. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Nine tumours induced by aflatoxin B1 in non-human primates (Macaca mulatta and M. fascicularis) were analysed for mutations in the p53 gene. These included 4 hepatocellular carcinomas, 2 cholangiocarcinomas, a spindle cell carcinoma of the bile duct, a haemangio-endothelial sarcoma of the liver and an osteogenic sarcoma of the tibia. None of the tumours showed changes at the third position of codon 249 by cleavage analysis of the HaeIII enzyme site at codon 249. A point mutation was identified in one hepatocellular carcinoma at the second position of codon 175 (G to T transversion) by sequencing analysis of the 4 conserved domains (II to V) in the p53 gene. It is concluded that mutations in the p53 gene are not necessary in aflatoxin B1 induced hepatocarcinogenesis in non-human primates. It is suggested that the occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249. KW - Aflatoxins KW - carcinogenesis KW - mutagenesis KW - Mycotoxins KW - poisoning KW - toxicity KW - monkeys KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fungal toxins KW - toxicosis KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211329&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does β-carotene explain why reduced cancer risk is associated with vegetable and fruit intake? AU - Ziegler, R. G. AU - Subar, A. F. AU - Craft, N. E. AU - Ursin, G. AU - Patterson, B. H. AU - Graubard, B. I. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 SP - 2060S EP - 2066S SN - 0008-5472 AD - Ziegler, R. G.: Environmental Epidemiology Branch and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921447442. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - A review of the literature indicates that increased intake of vegetables, fruits and carotenoids, and elevated blood levels of β-carotene, are consistently associated with the reduced risk of lung cancer in epidemiologic studies. Epidemiologic research also suggests that carotenoids may reduce the risk of other cancers, although the evidence is less extensive and consistent. The simplest explanation is that β-carotene is protective. However, the possible roles of other carotenoids, other constituents of vegetables and fruits, and associated dietary patterns have not been adequately explored. To evaluate these alternative hypotheses, the authors are undertaking 3 lines of research. (a) With dietary data from the 1987 National Health Interview Survey and the 1982-1984 Epidemiologic Follow-up of the first National Health and Nutrition Examination Study, it has been determined which food groups and nutrients are highly correlated with vegetable and fruit intake. (b) A liquid chromatography method for optimal recovery and resolution of the common carotenoids in blood, specifically lutein, zeaxanthin, β-cryptoxanthin, lycopene, α-carotene and β-carotene, has been developed. (c) In a population-based case-control study of lung cancer in white men in New Jersey, it is being assessed whether estimates of the intake of the individual carotenoids might produce stronger inverse associations than estimates of provitamin A carotenoids based on current food composition tables. KW - beta-carotene KW - Carcinoma KW - intake KW - reviews KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Nutrition and cancer KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921447442&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolic activation and genotoxicity of heterocyclic arylamines. AU - Synderwine, E. G. AU - Schut, H. A. J. AU - Adamson, R. H. AU - Thorgeirsson, U. P. AU - Thorgeirsson, S. S. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 SP - 2099S EP - 2102S SN - 0008-5472 AD - Synderwine, E. G.: Laboratory of Experimental Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921447472. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 13 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition N2 - Because of the potential for human exposure to mutagenic and carcinogenic heterocyclic arylamines (HAA) in the diet, the carcinogenicity of 3 HAAs, 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, is being evaluated by the authors in non-primates, especially cynomolgus monkeys. Concomitant with the carcinogenicity studies, the metabolic processing, disposition and DNA-adduct formation of these compounds are being examined in these monkeys. This report highlights the results from studies in monkeys and from in vitro models examining metabolic activation and genotoxicity of HAAs. The extent of in vivo activation of HAAs in monkeys was assessed by measuring DNA adducts in various tissues. Both 2-amino-3-methylimidazo[4,5-f]quinolone and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine formed high levels of DNA adducts in a number of organs, particularly the liver, kidney and heart. The implications of metabolic activation and DNA-adduct formation for the carcinogenicity of HAAs are discussed. KW - Carcinogenesis KW - DNA KW - foods KW - heterocyclic nitrogen compounds KW - USA KW - monkeys KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - deoxyribonucleic acid KW - Nutrition and cancer KW - United States of America KW - Food Science and Food Products (Human) (QQ000) KW - Animal Models of Human Nutrition (VV140) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921447472&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol and cancer. AU - Blot, W. J. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 SP - 2119S EP - 2123S SN - 0008-5472 AD - Blot, W. J.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921447476. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 52 ref. Subject Subsets: Human Nutrition N2 - Although ethanol had generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in man. Risk of oral, pharyngeal, laryngeal, oesophageal and liver cancer are elevated among drinkers, typically in proportion to the amount consumed. Evidence associating colorectal and breast cancer with alcohol drinking is suggestive but awaits confirmation. All types of alcoholic beverages seem to be implicated, pointing to an aetiological role for ethanol or its metabolites. The mechanisms, however, by which alcohol induces cancer in man are not clear. This review summarizes epidemiological studies of alcohol and cancer, focusing primarily on characteristics of the association that may provide clues to causal pathways. KW - alcoholic beverages KW - Carcinoma KW - reviews KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Nutrition and cancer KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) KW - Other Produce (QQ070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921447476&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells. AU - Levy, D. D. AU - Groopman, J. D. AU - Lim, S. E. AU - Seidman, M. M. AU - Kraemer, K. H. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 IS - 20 SP - 5668 EP - 5673 SN - 0008-5472 AD - Levy, D. D.: K. H. Kraemer, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921213344. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The mutagenic spectrum induced by aflatoxin-DNA lesions in DNA repair deficient and repair proficient human cells was investigated. The reactive metabolite aflatoxin B1-8,9-epoxide was synthesized and reacted in vitro with the shuttle vector plasmid pS189. Plasmids were transfected into human fibroblasts and allowed to replicate, and the recovered plasmids were screened in indicator bacteria for plasmid survival and mutations in the supF marker gene. Sequence data were obtained from 71 independently arising mutants recovered from DNA repair deficient xeroderma pigmentosum (XP) cells [XP12BE(SV40)] and 60 mutants recovered from a DNA repair proficient cell line (GM0637). Plasmid survival was lower and mutation frequency higher with the XP cells and the mutation hotspots differed substantially for the 2 cell lines. Most mutations (>90%) were base substitutions at G:C pairs, only about one-half of which were G:C->T:A transversions, the expected predominant mutation. One-third of the mutations at GG sites and none of those at isolated Gs were G:C->A:T transitions. Tandem base substitutions also occurred only at GG sites and were found only with XP cells. The location of mutation hotspots with either cell line did not correlate with the level of modification within the sequence as assessed by a DNA polymerase stop assay. It is suggested that the DNA repair deficiency associated with XP can influence not only the overall frequency of mutations but also the distribution of mutations within a gene. The finding of transition mutations exclusively at GG sites may be of predictive value in attempts to link dietary aflatoxin exposure to cancers associated with specific mutations in the c-ras oncogene and the p53 tumour suppressor gene. KW - Aflatoxins KW - mutagenesis KW - Mycotoxins KW - toxicity KW - fungal toxins KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921213344&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoid status and the control of keratin expression and adhesion during the histogenesis of squamous metaplasia of tracheal epithelium. AU - Lancillotti, F. AU - Darwiche, N. AU - Celli, G. AU - De Luca, L. M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1992/// VL - 52 IS - 22 SP - 6144 EP - 6152 SN - 0008-5472 AD - Lancillotti, F.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931459771. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Registry Number: 68238-35-7, 9008-18-8, 68-26-8. Subject Subsets: Human Nutrition N2 - Vitamin A depletion was induced to define early and late changes during the histogenesis of squamous metaplasia of hamster tracheal epithelium. An early change is the "minimal morphological change" (MMC), in which the mucociliary epithelium is separated from the basement membrane by a continuous layer of basal cells. Immunohistochemistry showed an exclusive localization of keratins K5 and K14 in basal cells of normal and MMC epithelia. At the MMC stage no staining was observed above the basal layer with antibodies to K5, but upon progression of the lesion to a squamous focus all cells from basal to terminally differentiated were positive for K5 and K14. When antibodies to the keratins K6 or K13 were used all cells were negative in the normal MMC epithelium. Successive layers of suprabasal squamous cells found in squamous metaplasia failed to express normal epidermal differentiation marker keratins K1 and K10 but expressed the proliferation marker keratin K6 and the internal stratified epithelium keratin K13, not normally found in the epidermis or trachea. Hamster tracheal epithelial cells could be maintained in culture in serum-free medium for at least 4 weeks in the presence of retinoic acid (RA). In non-RA-containing medium, cells from vitamin A-deficient hamsters showed markedly reduced growth and an increase in expression of keratins K5, K6, K13 and K14. Functional assays demonstrated that hamster tracheal epithelial cells, obtained from non-RA-treated tracheas or maintained in culture, displayed reduced attachment to laminin, compared to RA-treated cells. Immunofluorescence studies did not show a decrease in the α6 integrin subunit, which was localized in the basal aspect of basal cells, or in basement membrane laminin. However, expression of laminin-binding protein 37 decreased as the epithelium changed from pseudostratified to stratified. Therefore, a coordinated pattern of changes in keratin gene expression, and in the expression of laminin-binding protein 37, the precursor to the cell surface laminin receptor 67LR, and in adhesive properties takes place in tracheal epithelium when its phenotype changes from mucociliary to the preneoplastic stage of squamous metaplasia. KW - adhesion KW - Carcinoma KW - cell cultures KW - expressivity KW - keratin KW - nutritional state KW - Retinol KW - trachea KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - nutritional status KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459771&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a Plasmodium falciparum histone 2A gene. AU - Creedon, K. A. AU - Kaslow, D. C. AU - Rathod, P. K. AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 54 IS - 1 SP - 113 EP - 115 SN - 0166-6851 AD - Creedon, K. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920800136. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A P. falciparum gametocyte cDNA library constructed in pcDNAII yielded a clone which encoded histone 2A. The P. falciparum cDNA insert (477 bp), sequenced by the dideoxynucleotide method yielded the 396 bp open reading frame of pfh2a. A single methionine, preceeded by a stop codon, was found to initiate the histone sequence. The sequence encoded a basic protein comprising 132 amino acids, with a predicted MW of 14 100. It had 54.3-76.5% identity with the histones of fungi, protozoa, plants, invertebrates and vertebrates. There was no evidence for the presence of introns. RNA blots probed with radiolabelled pfh2a cDNA identified a 1.4 kb band in the total RNA of gametocytes, zygotes and erythrocytic stage parasites. The size of these bands are thought to indicate that long nucleotide sequences outside the pfh2a coding region are present in the mRNA transcript. KW - Genes KW - histones KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - DNA sequences KW - histone KW - histone 2A KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800136&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anti-HIV and cytotoxic alkaloids from Buchenavia capitata. AU - Beutler, J. A. AU - Cardellina, J. H., II AU - McMahon, J. B. AU - Boyd, M. R. AU - Cragg, G. M. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1992/// VL - 55 IS - 2 SP - 207 EP - 213 SN - 0163-3864 AD - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Building 1052, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19920314656. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Horticultural Science; Forestry; Forest Products N2 - The anti-HIV activity in the organic solvent extract of B. capitata leaves [see Weislow, O. S. et al., Journal of the National Cancer Institute (1989) 81, 577] was traced to a series of known flavonoid alkaloids, which represent a new chemotype for such activity. A bioassay-guided fractionation led to 3 alkaloids, the major constituent being O-demethylbuchenavianine. This compound showed only moderate cytotoxicity against HIV in cultured human lymphoblastoid cells. It was also cytotoxic in the National Cancer Institute human disease oriented in vitro tumour screening panel and produced a pattern of modest differential cellular sensitivity. KW - Alkaloids KW - Broadleaves KW - characterization KW - composition KW - Cytotoxic compounds KW - Foliage KW - leaves KW - Medicinal plants KW - medicinal properties KW - Plant composition KW - trees KW - woody plants KW - plants KW - eukaryotes KW - Combretaceae KW - Myrtales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Buchenavia KW - Buchenavia capitata KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Non-wood Forest Products (KK540) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920314656&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food intake measured by an automated food-selection system: relationship to energy expenditure. AU - Rising, R. AU - Alger, S. AU - Boyce, V. AU - Seagle, H. AU - Ferraro, R. AU - Fontvieille, A. M. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1992/// VL - 55 IS - 2 SP - 343 EP - 349 SN - 0002-9165 AD - Rising, R.: National Institutes of Health, 4212 N 16th Street Room 541-A, Phoenix, AZ 85016, USA. N1 - Accession Number: 19921452528. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - An automated food-selection system with 2 vending machines containing a large variety of foods was used to estimate food intake in 10 men (31±6 years old, 69.2±7.1 kg, 18±7% fat, mean ± s.d.) on a metabolic ward. The effect of carbohydrate, fat and protein intakes on 24 h energy expenditure (24EE) and substrate oxidations was estimated in a respiratory chamber during day 4 of weight maintenance and day 7 of feeding freely. Feeding freely resulted in a 7-day overfeeding of 6468±3824 kJ/day above weight-maintenance requirements, leading to a 2.3±1.2-kg gain. The 10 975±3774 kJ excess energy intake on day 7 of feeding freely caused a 1205±920 kJ/day increase in 24EE (Δ24EE = 0.17 ×Δintake - 695; r = 0.71, P<0.02). Of the excess carbohydrate intake, 74% was oxidized (r = 0.86, P<0.001), whereas excess fat intake was not. It is concluded that carbohydrate and protein stores are regulated whereas excess fat intake is channeled to fat stores. KW - energy exchange KW - estimation KW - Food intake KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921452528&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytotoxic quassinoids from Cedronia granatensis. AU - Tischler, M. AU - Cardellina, J. H., II AU - Boyd, M. R. AU - Cragg, G. M. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1992/// VL - 55 IS - 5 SP - 667 EP - 671 SN - 0163-3864 AD - Tischler, M.: Laboratory of Drug Discovery Research and Development, National Cancer Institute Building 1052, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19950609390. Publication Type: Journal Article. Language: English. Number of References: 14 ref. N2 - From leaves and twigs of Cedronia granatensis [Picrolemma granatensis]. KW - chemical composition KW - cytotoxicity KW - foliage KW - forest trees KW - leaves KW - plant composition KW - quassinoids KW - trees KW - woody plants KW - plants KW - Simaroubaceae KW - eukaryotes KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Simaroubaceae KW - chemical constituents of plants KW - Picrolemma KW - Picrolemma granatensis KW - Rutales KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950609390&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men. AU - Micozzi, M. S. AU - Brown, E. D. AU - Edwards, B. K. AU - Bieri, J. G. AU - Taylor, P. R. AU - Khachik, F. AU - Beecher, G. R. AU - Smith, J. C., Jr. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1992/// VL - 55 IS - 6 SP - 1120 EP - 1125 SN - 0002-9165 AD - Micozzi, M. S.: P. R. Taylor, Cancer Prevention Studies Branch, National Cancer Institute, Executive Plaza North, Suite 211, Bethesda, MD 20892, USA. N1 - Accession Number: 19921451894. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - Serial changes in 4 major plasma carotenoid fractions (α-carotene, β-carotene, lutein/zeaxanthin, and lycopene) were estimated in 30 men, 20 to 45 years old, consuming defined daily doses of carotenoids from foods (broccoli, carrots, or tomato juice) or from purified β-carotene in capsules (12 or 30 mg) for 6 weeks while fed on a controlled diet. Compared with baseline, β-carotene increased in the 30- and 12-mg-capsule and carrot groups whereas α-carotene increased in the carrot group and lutein increased in the broccoli group. Lower lutein concentrations in recipients of β-carotene capsules suggested an interaction between these 2 carotenoids. Lycopene decreased in all groups except the tomato-juice group. Total carotenoid concentration changes only reflected the large increases in β-carotene concentrations and not the smaller changes observed in other individual carotenoids. Overall, purified β-carotene produced a greater plasma response than did similar quantities of carotenoids from food sources. KW - beta-carotene KW - blood KW - broccoli KW - carotenoids KW - carrots KW - intake KW - Men KW - supplements KW - tomato juice KW - Brassica oleracea KW - Daucus carota KW - Man KW - Brassica KW - Brassicaceae KW - Capparidales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Daucus KW - Apiaceae KW - Apiales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Araliales KW - calabrese KW - Capparales KW - tetraterpenoids KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921451894&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A brief overview of human energy metabolism and its relationship to essential obesity. AU - Ravussin, E. AU - Bogardus, C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1992/// VL - 55 IS - Suppl. 1 SP - 242S EP - 245S SN - 0002-9165 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19921450020. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition N2 - Human energy metabolism is reviewed in relation to essential obesity. Topics covered include determinants of daily energy expenditure, low metabolic rate as a risk factor for weight gain, and components of daily energy expenditure. KW - Energy metabolism KW - obesity KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921450020&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a cryptic intron in the Plasmodium vivax Duffy binding protein gene. AU - Adams, J. H. AU - Fang, X. D. AU - Kaslow, D. C. AU - Miller, L. H. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 56 IS - 1 SP - 181 EP - 183 SN - 0166-6851 AD - Adams, J. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930802439. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A revised deduced amino acid sequence of the P. vivax Duffy binding protein is presented, based as new data from polymerase chain reaction-amplified reverse-transcribed mRNA. When the nucleotide sequence of the genes encoding the Duffy binding protein of P. vivax and P. knowlesi β gene were aligned, the sequences were similar before and after, but not within the region where the P. knowlesi β intron is found. P. vivax cDNA was synthesized from total cellular RNA with an antisense oligonucleotide 100 bp downstream from the possible intron and then was amplified by PCR using the cDNA primer and a sense oligonucleotide 500 bp upstream of a possible intron. The major cDNA PCR product was (135 bp) smaller than the PCR product of a genomic clone, indicating that the intron was spliced. The cDNA PCR product was sequenced directly using radiolabelled internal primers by Taq polymerase-based cycle sequencing. The cDNA sequence confirmed that the intron was removed in the major P. vivax transcript giving rise to an amino acid sequence homologous to the P. knowlesi β gene. KW - amino acid sequences KW - COMPLEMENTARY DNA KW - Genes KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - Polymerase chain reaction KW - proteins KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium vivax KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - cDNA KW - DNA sequences KW - Duffy binding KW - Duffy binding protein KW - PCR KW - protein sequences KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802439&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - α-Tubulin II is a male-specific protein in Plasmodium falciparum. AU - Rawlings, D. J. AU - Fujioka, H. AU - Fried, M. AU - Keister, D. B. AU - Aikawa, M. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1992/// VL - 56 IS - 2 SP - 239 EP - 250 SN - 0166-6851 AD - Rawlings, D. J.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930802715. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The tubulin gene family in P. falciparum consists of one β-tubulin and 2 α-tubulin genes (α-tubulin I and II). Data is presented which indicated that α-tubulin II is expressed only in male sexual stage parasites. An IgM MAb, 5E7, specifically reacted with stage III (day 4-5) to mature (day 10-11) male gametocytes and with emerging, exflagellating, or freely moving male gametes. No reactivity was detected in female gametocytes, female gametes, sporozoites, or asexual parasites. MAb 5E7 also specifically recognized male gametes of the avian parasite Plasmodium gallinaceum, and immunoblotted a 50 000 MW protein in extracts of male gametes from both species. This 50 000 MW antigen was localized by immunoelectron microscopy to axonemes of male gametes in a pattern similar to that obtained with anti-α- and anti-β-tubulin antibodies. Furthermore, MAb 5E7 specifically reacted with recombinant α-tubulin II protein obtained using the PCR-amplified α-tubulin II gene from a gametocyte-specific cDNA library. The sex-specific expression of α-tubulin II and its localization to axoneme of the male parasite suggest a role for this molecule in the morphologic changes that occur during exflagellation and in the motility of the parasite. KW - Biochemistry KW - Human diseases KW - Monoclonal antibodies KW - parasites KW - Sex differences KW - tubulin KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - alpha-tubulin II KW - male gametes KW - male gametocytes KW - sex-specific KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802715&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Brain transfer coefficients for 67Ga: comparison to 55Fe and effect of calcium deficiency. AU - Murphy, V. A. AU - Rapoport, S. I. JO - Journal of Neurochemistry JF - Journal of Neurochemistry Y1 - 1992/// VL - 58 IS - 3 SP - 898 EP - 902 SN - 0022-3042 AD - Murphy, V. A.: Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931464945. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7440-70-2, 7440-55-3, 7439-89-6. Subject Subsets: Human Nutrition N2 - The transfer coefficients (Kin) for the uptake of gallium-67 into brain and cerebrospinal fluid (CSF) were estimated in unanaesthetized male Fischer-344 rats given adult normal or low in calcium diets. Kin for 67Ga was also compared with transfer coefficients for uptake of of iron-55 and 125I-albumin in controls. The value of CSF67Ga Kin was 3 × 10-7 ml g-1 s-1 and was 50% larger in low-Ca rats. Brain regional Kin values for 67Ga were 3-9 × 10-7 ml g-1 s-1 with no difference in Kin between normal and low-Ca rats. CSF Kin values for 55Fe were 40% and those for albumin were 15% of Kin for 67Ga. For brain, Kin values for 55Fe were 15 to 40% smaller than for 67Ga, but for albumin the Kin values were 85% less than for 67Ga. 67Ga was 99% bound to plasma proteins, whereas 55Fe was 99.9% bound. The results indicate that metals that are primarily bound to transferrin enter the CSF and brain very slowly. Uptake of both metals was faster than albumin, which may indicate that metal bound to small chelates contributes significantly to brain uptake. Ca deficiency does not enhance entry of Ga into the brain. KW - blood protein KW - brain KW - calcium KW - cerebrospinal fluid KW - deficiency KW - Gallium KW - Iron KW - Isotopes KW - Transfer KW - uptake KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - plasma protein KW - serum protein KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464945&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment and developmental therapeutics in aspergillosis. 1. Amphotericin B and its derivatives. AU - St. Georgiev, V. JO - Respiration JF - Respiration Y1 - 1992/// VL - 59 IS - 5 SP - 291 EP - 302 SN - 0025-7931 AD - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200527. Publication Type: Journal Article. Language: English. Number of References: 139 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The treatment of infections caused by Aspergillus spp. with amphotericin B, its clinical efficacy, toxicity and routes of administration are reviewed. Liposome-encapsulated amphotericin B, amphotericin B complexes with deoxycholate and cholesterol sulfate, combinations of amphotericin B with other drugs and amphotericin B esters are discussed. The anti-Aspergillus activity of other polyene antibiotics (nystatin, hamycin, natamycin, ambruticin), benzo[a]naphthacenequinone antibiotics, nikkomycins and cilofungins are also considered. KW - amphotericin B KW - reviews KW - therapy KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200527&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment and developmental therapeutics in aspergillosis. 2. Azoles and other antifungal drugs. AU - St. Georgiev, V. JO - Respiration JF - Respiration Y1 - 1992/// VL - 59 IS - 5 SP - 303 EP - 313 SN - 0025-7931 AD - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200528. Publication Type: Journal Article. Language: English. Number of References: 131 ref. Registry Number: 23593-75-1, 86386-73-4, 84625-61-6, 65277-42-1, 22916-47-8. Subject Subsets: Medical & Veterinary Mycology N2 - The use of azole derivatives (including clotrimazole, miconazole, ketoconazole, fluconazole and itraconazole), miscellaneous antifungal compounds (such as flucytosine) and granulocyte colony-stimulating factor in the treatment of Aspergillus infections is reviewed. Sodium (potassium) iodide therapy of aspergilloma and therapy of allergic bronchopulmonary aspergillosis and Aspergillus-induced otomycosis are also considered. KW - allergic bronchopulmonary aspergillosis KW - allergies KW - azoles KW - clotrimazole KW - ears KW - fluconazole KW - infections KW - itraconazole KW - ketoconazole KW - lungs KW - miconazole KW - therapy KW - Aspergillus KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - ABPA KW - fungus KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200528&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic association of mating types and virulence in Cryptococcus neoformans. AU - Kwon-Chung, K. J. AU - Edman, J. C. AU - Wickes, B. L. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 2 SP - 602 EP - 605 SN - 0019-9567 AD - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211030. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A pair of congenic C. neoformans strs., B-4476 (a mating type) and B-4500 (α mating type), that presumably differ only in mating type was constructed. This pair and their progeny, 5 α type and 5 a type, were tested for virulence in mice. In the parent strains as well as the progeny, α type was clearly more virulent than a type. In addition, death tended to occur earlier among the α-strain-infected mice that died than among the mice that died by infection caused by a strs. It is suggested that there is genetic association of virulence with mating type in C. neoformans. KW - genetics KW - infections KW - pathogenicity KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211030&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interactions between extracellular Borrelia burgdorferi proteins and non-Borrelia-directed immunoglobulin M antibodies. AU - Dorward, D. W. AU - Huguenel, E. D. AU - Davis, G. AU - Garon, C. F. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 3 SP - 838 EP - 844 SN - 0019-9567 AD - Dorward, D. W.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19940503577. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 308067-57-4. Subject Subsets: Medical & Veterinary Entomology N2 - Previous work showed that outer surface protein A (OspA) and OspB of B. burgdorferi may occur within an extracellular multiprotein complex, which was resolved by electrophoresis as an 83-kDa major extracellular protein band. To characterize the 83-kDa band the N terminus of the predominant peptide in the band was sequenced and the interaction between the associated proteins examined. Peptide sequence and amino acid composition comparisons showed identity with the heavy chain of IgM. Reduction sensitivity experiments and the recognition of the band by antibodies specific for rabbit µ chain indicated that the multiprotein complex contained pentameric IgM. Immunoelectron microscopy showed that anti-µ chain antibodies and monoclonal antibodies to OspA and OspB bound to extracellular amorphous material surrounding cells. Furthermore, the Osps coprecipitated with either non-specific polyclonal rabbit IgM antibodies or with murine monoclonal anti-human serum albumin IgM antibodies, using insoluble anti-µ chain antibody conjugates. Although the apparent 83-kDa complex was stable under conditions of chelation and concentrated salts, it was disrupted by treatment with neuraminidase. The results indicated that extracellular B. burgdorferi proteins, including OspA and OspB, interact with IgM. The association is apparently not a classic antibody-antigen interaction but may result from other mechanisms. KW - amino acid sequences KW - antigen antibody reactions KW - antigens KW - IgM KW - immunoglobulins KW - proteins KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenic reactions KW - antigenicity KW - bacterium KW - gamma-globulins KW - immune globulins KW - immunogens KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940503577&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans. AU - Varma, A. AU - Edman, J. C. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 3 SP - 1101 EP - 1108 SN - 0019-9567 AD - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211460. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology; Agricultural Biotechnology N2 - C. neoformans ura5 mutants were transformed with linearized or circular plasmids containing the C. neoformans orotidine monophosphate pyrophosphorylase gene. Following electroporation, randomly isolated transformants were analysed for the mitotic and meiotic stability of uracil prototrophy. All stable transformants tested showed non-specific ectopic integration. Uracil prototrophy in these transformants was stable through meiosis. Some of the stable transformants showed integration of both URA5 and vector sequences, while others lacked any vector sequences. Unstable transformants exhibited the presence of an autonomously replicating plasmid which had undergone significant sequence rearrangement. The autonomously replicating plasmid in the transformants was observed to be the same size or smaller than the transforming plasmid, was maintained in a linear form and had acquired a genomic sequence(s) with homology to a sequence(s) on all the chromosomes. The conservation of a 300-bp sequence at the 5′ end of the URA5 gene was observed in all the rearranged plasmids. It is suggested that there are mechanisms of plasmid maintenance in C. neoformans that are different from those reported for other yeasts. The ura5 mutant was significantly less virulent than the wild type. The transformants did not recover virulence regardless of prototrophic stability. KW - Biotechnology KW - gene transfer KW - genetics KW - Plasmids KW - transformation KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211460&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modulation of a surface antigen of Entamoeba histolytica in response to bacteria. AU - Bhattacharya, A. AU - Ghildyal, R. AU - Prasad, J. AU - Bhattacharya, S. AU - Diamond, L. S. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 4 SP - 1711 EP - 1713 SN - 0019-9567 AD - Bhattacharya, A.: L.S. Diamond, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878764. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - Changes in the cell surface of E. histolytica were examined with MAb, 2D7.10, which selectively recognizes carbohydrate epitopes in some axenic amoebic strains. While high-level expression of this epitope was observed in axenic amoebae, it was either absent or present only in small amounts in xenic amoebae. Furthermore, reassociation of the axenic amoebae with intestinal flora resulted in loss of the 2D7.10 epitope. The data suggest that surface antigens of E. histolytica can be modulated in response to bacteria and may provide an explanation for the observed influence of bacteria on amoebic virulence. KW - antigens KW - Epitopes KW - Human diseases KW - interactions KW - Monoclonal antibodies KW - parasites KW - Pathogenicity KW - bacteria KW - Endamoebidae KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - prokaryotes KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Endamoebidae KW - antigenic determinants KW - antigenicity KW - bacterium KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878764&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Virulence, serotype, and molecular characteristics of environmental strains of Cryptococcus neoformans var. gattii. AU - Kwon-Chung, K. J. AU - Wickes, B. L. AU - Stockman, L. AU - Roberts, G. D. AU - Ellis, D. AU - Howard, D. H. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 5 SP - 1869 EP - 1882 SN - 0019-9567 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211749. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Four strains of C. neoformans var. gattii originating from Eucalyptus camaldulensis, 3 from Australia and 1 from San Francisco, were tested for their serotype, virulence for mice and a number of genetic and molecular characteristics. All were found to be serotype B and showed significantly higher virulence for mice than did the type strains of C. neoformans var. gattii and Filobasidiella neoformans var. bacillispora, which were obtained from human cryptococcosis cases. Electrophoretic karyotypes of the strains from Australia were identical, although they were collected from sites at least 15-500 km apart. The electrophoretic karyotype of the strain from San Francisco was the same as that of the Australian isolates except for the mobility of one chromosome. On the contrary, no 2 isolates of serotype B (of a total of 11) from clinical sources were the same, regardless of their geographical origin. Furthermore, none of the clinical isolates showed a chromosomal banding patttern identical to that of Eucalyptus-originated strains. The Eucalyptus-originated strains failed to form dikaryons when crossed with the tester strains of the 2 varieties of F. neoformans. Hybridization analysis with a nucleic acid probe (AccuProbe) showed signals of equal intensity for clinical strains and the Eucalyptus-originated strains. Various fungi phylogenetically related to C. neoformans, including a phenol oxidase-positive strain of C. laurentii obtained from E. camaldulensis, were negative in the nucleic acid hybridization test. It is concluded that in spite of karyotypic differences and the lack of dikaryon formation with the tester strains of F. neoformans, Eucalyptus-originated C. neoformans var. gattii is the same organism as those isolated from cases of human infection. Furthermore, the C. neoformans culture confirmation test using a commercial nucleic acid probe is specific for C. neoformans. KW - contamination KW - genetics KW - immunology KW - karyotypes KW - pathogenicity KW - serotypes KW - Australia KW - USA KW - Cryptococcus gattii KW - Eucalyptus KW - mice KW - Cryptococcus (Fungi) KW - Cryptococcus neoformans KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Myrtaceae KW - Myrtales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - North America KW - America KW - Cryptococcus neoformans var. gattii KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211749&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses. AU - Gazzinelli, R. T. AU - Hartley, J. W. AU - Fredrickson, T. N. AU - Chattopadhyay, S. K. AU - Sher, A. AU - Morse, H. C., III JO - Infection and Immunity JF - Infection and Immunity Y1 - 1992/// VL - 60 IS - 10 SP - 4394 EP - 4401 SN - 0019-9567 AD - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19920801634. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - Mice infected with LP-BM5 murine leukaemia viruses develop a syndrome, termed mouse acquired immune deficiency syndrome (MAIDS), characterized by increasingly severe immunodeficiency and progressive lymphoproliferation. Virus-infected C57BL/6 mice were examined for the ability to resist acute infection and to control chronic infection with T. gondii. Mice infected with the retroviruses for 2 or 4 weeks responded normally to challenge with the parasite, but mice inoculated 8 or 12 weeks after viral infection died with acute disease due to T. gondii. Increased sensitivity to acute infection was associated with a reduced ability to produce gamma interferon (IFN-γ) and with established changes in CD4+ T-cell function. Mice latently infected with T. gondii and then inoculated with the retrovirus mixture were found to reactivate the parasite infection, with 30 to 40% of dually infected animals dying between 5 and 16 weeks after viral infection. Reactivation was associated with reduced proliferation and impaired production of IFN-γ in response to stimulation with soluble T. gondii antigens or to concanavalin A. Continuing resistance to lethal reactivation in the remaining mice was shown to require CD8+ T cells and expression of IFN-γ. In addition, it was found that chronic infection with T. gondii altered the course of MAIDS by inhibiting the progression of splenomegaly and immunodeficiency and reducing the expression of both the helper and aetiological defective viruses. These results support previous studies which indicate that infection with T. gondii is controlled by synergistic interactions between CD4+ and CD8+ T cells, the functions of which are progressively impaired during the course of MAIDS. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - animal models KW - Disease models KW - Experimental infections KW - Human diseases KW - immune response KW - immunocompromised hosts KW - Immunology KW - Interferon KW - Laboratory animals KW - Opportunistic infections KW - parasites KW - T lymphocytes KW - Toxoplasmosis KW - Apicomplexa KW - mice KW - Muridae KW - protozoa KW - Rodents KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - AIDS KW - Function KW - immunity reactions KW - immunological reactions KW - Murine KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801634&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease. AU - Cahour, A. AU - Falgout, B. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1992/// VL - 66 IS - 3 SP - 1535 EP - 1542 SN - 0022-538X AD - Cahour, A.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19940500292. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The cleavage mechanism utilized for processing of the NS3-NS4A-NS4B-NS5 domain of the dengue virus polyprotein was studied by using the vaccinia virus expression system. Recombinant vaccinia viruses vNS2B-NS3-NS4A-NS4B-NS5, vNS3-NS4A-NS4B-NS5, vNS4A-NS4B-NS5 and vNS4B-NS5 were constructed. These recombinants were used to infect cells, and the labelled lysates were analysed by immunoprecipitation. Recombinant vNS2B-NS3-NS4A-NS4B-NS5 expressed the authentic NS3 and NS5 proteins, but the other recombinants produced uncleaved polyproteins. These findings indicate that NS2B is required for processing of the downstream nonstructural proteins, including the NS3/NS4A and NS4B/NS5 junctions, both of which contain a dibasic amino acid sequence preceeding the cleavage site. The flavivirus NS4A/NS4B cleavage site follows a long hydrophobic sequence. The polyprotein NS4A-NS4B-NS5 was cleaved at the NS4/NS4B junction in the absence of other dengue virus functions. One interpretation for this finding is that NS4A/NS4B cleavage is mediated by a host protease, presumably a signal peptidase. Although vNS3-NS4A-NS4B-NS5 expressed only the polyprotein, earlier results demonstrated that cleavage at the NS4A/NS4B junction occurred when an analogous recombinant, vNS3-NS4A-84%NS4B, was expressed. Thus, it appears that uncleaved NS3 plus NS5 inhibit NS4A/NS4B cleavage presumably because the putative signal sequence is not accessible for recognition by the responsible protease. Finally, recombinants that expressed an uncleaved NS4B-NS5 polyprotein, such as vNS4A-NS4B-NS5 or vNS4B-NS5, produced NS5 when complemented with vNS2B-30%NS3 or with vNS2B plus v30%NS3. These results indicate that cleavage at the NS4B/NS5 junction can be mediated by NS2B and NS3 in trans. KW - arboviruses KW - cleavage KW - proteinases KW - viral proteins KW - dengue virus KW - Flavivirus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - polyproteins KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500292&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bovine immunodeficiency-like virus encodes factors which trans activate the long terminal repeat. AU - Pallansch, L. A. AU - Lackman-Smith, C. S. AU - Gonda, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1992/// VL - 66 IS - 5 SP - 2647 EP - 2652 SN - 0022-538X AD - Pallansch, L. A.: M. A. Gonda, Laboratory of Cell and Molecular Structure, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1202, USA. N1 - Accession Number: 19922268493. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Veterinary Science; Agricultural Biotechnology N2 - Lentiviruses are known to encode factors which trans activate expression from the viral long terminal repeat (LTR); the primary trans activator is the tat gene product. One of the putative accessory genes (tat) of the bovine immunodeficiency-like virus (BIV) bears sequence similarity to other lentivirus tat genes. This finding suggests that BIV may encode a trans-activating protein capable of stimulating LTR-directed gene expression. To test this hypothesis in vitro, BIV LTR-chloramphenicol acetyltransferase (CAT) reporter gene plasmids were constructed and transfected into 3 cell lines from canine, bovine or lapine tissues that are susceptible to BIV infection. The level of BIV LTR-directed CAT gene expression was increased in BIV-infected cells compared with uninfected cells. The relatively high basal-level expression of BIV LTR-CAT in uninfected canine and bovine cell lines suggests that cellular factors play a role in regulating BIV LTR-directed gene expression. Additionally, by using a clonal canine cell line in which the BIV LTR-CAT plasmid in stably expressed, BIV LTR-directed CAT expression is increased 15- to 90-fold by cocultivation with BIV-infected cells, supporting the notion that BIV encodes a trans activator. The relative specificity of this viral activation was assessed by coculturing the clonal BIV LTR-CAT cell line with bovine leukosis virus- or bovine syncytial virus-infected cells; these bovine retroviruses increased expression from the BIV LTR only two- to threefold. Thus, BIV LTR regulatory elements in infected cells, like those of human immunodeficiency virus type 1 and other lentiviruses, are trans activated, presumably through the action of a Tat-like protein and cellular factors. KW - Biotechnology KW - Cell culture KW - Gene expression KW - Molecular biology KW - Nucleotide sequences KW - Regulation KW - Transactivation KW - Bovine immunodeficiency virus KW - LENTIVIRUS KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA sequences KW - Long terminal repeat KW - transcriptional activation KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922268493&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunological characterization of the gag gene products of bovine immunodeficiency virus. AU - Battles, J. K. AU - Hu, M. Y. AU - Rasmussen, L. AU - Tobin, G. J. AU - Gonda, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1992/// VL - 66 IS - 12 SP - 6868 EP - 6877 SN - 0022-538X AD - Battles, J. K.: Laboratory of Cell and Molecular Structure, Program Resources, Inc./Dyn Corp., National Cancer Institute Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702-1201 USA. N1 - Accession Number: 19932278411. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - The bovine immunodeficiency virus (BIV) gag gene encodes a 53-kDa precursor (Pr53gag) that is involved in virus particle assembly and is further processed into the putative matrix (MA), capsid (CA), and nucleocapsid (NC) functional domains in the mature virus. Gag determinants are also found in the Gag-Pol polyprotein precursor. To immunologically identify the major precursors and processed products of the BIV gag gene, monospecific rabbit sera to recombinant BIV MA protein and Pr53gag and peptides predicted to correspond to the CA and NC proteins and the MA-CA cleavage site were developed and used in immunoprecipitations and immunoblots of BIV antigens. Monospecific antisera to native and recombinant human immunodeficiency virus type 1 proteins were also used to identify analogous BIV Gag proteins and to determine whether cross-reactive epitopes were present in the BIV Gag precursors or processed products. The BIV MA, CA, and NC Gag proteins were identified as p15, p26, and p13, respectively. In addition to BIV Pr53gag, the major Gag precursor, 2 other Gag-related precursors of 170 and 49 kDa were identified that have been designated pPr170gag-pol and Pr49gag, respectively; pPr170gag-pol is the Gag-Pol polyprotein precursor, and Pr49gag is the transframe Gag precursor present in pPr170gag-pol. Several alternative Gag cleavage products were also observed, including p23, which contain CA and NC determinants, and p10, which contains a peptide sequence conserved in the CA proteins of most lentiviruses. The monospecific antisera to human immunodeficiency virus type 1 CA (p24) and NC (p7) proteins showed cross-reactivity to and aided in the identification of analogous BIV proteins. Based on these results, a scheme for the processing of BIV Gag precursors is proposed. KW - coat proteins KW - epitopes KW - Gag protein KW - Gene expression KW - Immunoblotting KW - Immunology KW - matrix proteins KW - nucleocapsid proteins KW - viral diseases KW - viral proteins KW - Bovine immunodeficiency virus KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenic determinants KW - capsid proteins KW - viral infections KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932278411&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutational analysis of the octapeptide sequence motif at the NS1-NS2A cleavage junction of dengue type 4 virus. AU - Pethel, M. AU - Falgout, B. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1992/// VL - 66 IS - 12 SP - 7225 EP - 7231 SN - 0022-538X AD - Pethel, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950506330. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - It has previously been shown that proper processing of dengue type 4 virus NS1 from the NS1-NS2A region of the viral polyprotein requires a hydrophobic N-terminal signal and the downstream NS2A. Results from deletion analysis indicate that a minimum length of 8 amino acids at the C terminus of NS1 is required for cleavage at the NS1-NS2A junction. Comparison of this 8-amino-acid sequence with the corresponding sequences of other flaviviruses suggests a consensus cleavage sequence of Met/Leu-Val-Xaa-Ser-Xaa-Val-Xaa-Ala. Site-directed mutagenesis was performed to construct mutants of NS1-NS2A which contained a single amino acid substitution at different positions of the consensus cleavage sequence or at the immediate downstream position. 3-8 different substitutions were made at each position. A total of 50 NS1-NS2A mutants were analyzed for their cleavage efficiency relative to that of the wild-type dengue type 4 virus sequence. As predicted, nearly all substitutions at position P1, P3, P5, P7 and P8, occupied by conserved amino acids, yielded low levels of cleavage, with the exception that Pro or Ala substituting for Ser (P5) was tolerated. Substitutions of an amino acid at the remaining positions occupied by nonconserved amino acids generally yielded high levels of cleavage. Some substitutions at nonconserved positions were, however, not tolerated. For example, substitution of Gly or Glu for Gln (P4) and substitution of Val or Glu for Lys (P6) each yielded a low level of cleavage. Overall, these data support the proposed cleavage sequence motif deduced by comparison of sequences among the flaviviruses. This study also showed that in addition to the 8-amino-acid sequence, the amino acid immediately following the NS1-NS2A cleavage site plays a role in cleavage. KW - amino acid sequences KW - amino acids KW - arboviruses KW - cleavage KW - mutants KW - peptides KW - dengue 4 virus KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Conservation of repeating structures in the PfEMP2/MESA protein of Plasmodium falciparum. AU - Saul, A. AU - Yeganeh, F. AU - Howard, R. J. JO - Immunology and Cell Biology JF - Immunology and Cell Biology Y1 - 1992/// VL - 70 IS - 5 SP - 353 EP - 355 SN - 0818-9641 AD - Saul, A.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19950806498. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A large antigenic protein, referred to as MESA, PfEMP2 or PP330, accumulates under the plasma membrane of erythrocytes infected with mature asexual stages of Plasmodium falciparum. Sequences from the gene coding this protein in the Malayan Camp isolate of P. falciparum are described and compared with the full sequence previously described for the FCQ27/PNG isolate, which is dominated by a complicated set of repeats. The sequences from the Malayan Camp isolate show that, unlike several other malarial proteins which have variant repeats (such as the S antigens), the repeats in MESA/PfEMP2 are conserved. KW - antigens KW - erythrocytes KW - genes KW - merozoites KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - strains KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - biochemical genetics KW - blood red cells KW - DNA sequences KW - immunogens KW - merozoite surface antigens KW - PfEMP2 repeats KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806498&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of a novel multicopy, repetitive sequence of Plasmodium falciparum, REP51. AU - Saul, A. AU - Yeganeh, F. AU - Howard, R. J. JO - Immunology and Cell Biology JF - Immunology and Cell Biology Y1 - 1992/// VL - 70 IS - 5 SP - 357 EP - 359 SN - 0818-9641 AD - Saul, A.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19950806499. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology N2 - A genomic library of Plasmodium falciparum was constructed by digestion of DNA from the Malayan Camp Aotus monkey-adapted isolate under conditions which gave gene-sized fragments. Four to 16 kb-sized fragments were separated by agarose gel electrophoresis and cloned. An array of 450 clones containing inserts was prepared and characterized by examination of the Sau3AI digestion profiles of the plasmid DNA of 250 of these clones and by hybridization of the inserts from selected clones to the whole array. Three multicopy families were found, of which 2 corresponded to previously described multicopy sequences in the P. falciparum genome. Cloning and characterization of a novel multicopy repetitive sequence (REP51) from members of the third family are described. KW - DNA KW - DNA libraries KW - electrophoresis KW - genes KW - genomes KW - multigene families KW - nucleotide sequences KW - parasites KW - repetitive DNA KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cloning KW - deoxyribonucleic acid KW - DNA sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806499&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transforming growth factor-alpha in human hepatocellular carcinoma and coexpression with hepatitis B surface antigen in adjacent liver. AU - Hsia, C. C. AU - Axiotis C. A. AU - Di Bisceglie, A. M. AU - Tabor, E. JO - Cancer JF - Cancer Y1 - 1992/// VL - 70 IS - 5 SP - 1049 EP - 1056 SN - 0008-543X AD - Hsia, C. C.: (E. Tabor) National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050154. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The mechanisms by which hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) are not known. Transforming growth factor-alpha (TGF-α), a regulator of growth and regeneration in rat liver that can be found in high levels in some human cancers, theoretically could play such an intermediate role in the development of HCC. The authors evaluated the expression of TGF-α and its relation to the HBV antigens in human HCC and adjacent non-tumourous livers from 33 patients from the USA and China using immunoperoxidase staining of paraffin-embedded sections. They detected TGF-α in HCC from 27 of 33 (82%) patients; the frequencies were similar in patients from the USA and China. TGF-α was detected in HCC more frequently in patients whose adjacent non-tumourous livers had detectable hepatitis B surface antigen (HBsAg) and/or hepatitis B core antigen (HBcAg) than in those whose adjacent livers lacked HBsAg and HBcAg. Detection of TGF-α was not affected by tumour size, histological type, or grade. TGF-α was detected in adjacent non-tumourous livers from 31 of 33 patients (94%). Co-expression at a high intensity of TGF-α and HBsAg in the same hepatocytes could be demonstrated by specific staining of consecutively cut sections for 17 of 33 patients (52%). TGF-α is expressed at a high level in 82% of human HCC. Localization of HBsAg within the same hepatocytes as TGF-α suggests a possible interaction between HBV and TGF-α during hepatocarcinogenesis in humans. Stimulation of TGF-α expression could be part of a chain of events by which HBV contributes to the development of HCC in some patients. [An interesting study.]From AS/Anna Korczak-Rogon´ KW - growth factors KW - hepatitis B KW - liver KW - neoplasms KW - cancer sites KW - cancers KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050154&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Patterns of infection in patients with aplastic anemia and the emergence of Aspergillus as a major cause of death. AU - Weinberger, M. AU - Elattar, I. AU - Marshall, D. AU - Steinberg, S. M. AU - Redner, R. L. AU - Young, N. S. AU - Pizzo, P. A. JO - Medicine (Baltimore) JF - Medicine (Baltimore) Y1 - 1992/// VL - 71 IS - 1 SP - 24 EP - 43 SN - 0025-7974 AD - Weinberger, M.: P. A. Pizzo, Infectious Disease Section, Pediatric Branch, Clinical Oncology Program, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921212361. Publication Type: Journal Article. Language: English. Number of References: 81 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Patterns of infection were retrospectively studied in 150 patients (60% male, mean age 33.6 yrs) with aplastic anaemia admitted during Jan. 1978-Dec. 1989 for immunosuppressive therapy. A total of 103 patients developed 1 or more febrile episodes during the study period. The risk factors for developing a febrile episode included a low absolute neutrophil count (ANC) and absolute monocyte count (AMC) at admission and the presence of an indwelling central venous catheter. A total of 289 febrile events were studied, including unexplained fever in 89 (31%), microbiologically documented infection in 137 (47%) and clinically documented infection (CDI) in 63 patients (22%). Among CDI events, bacteria were the most commonly defined aetiological agent (67%), followed by fungi (23%), viruses (7%) and parasites (Pneumocystis carinii) (3%). 21 patients (15%) developed invasive fungal infections due to Aspergillus (A. flavus, A. fumigatus, A. nidulans, Aspergillus sp.) in 11, Candida (C. albicans, Torulopsis glabrata, C. tropicalis, C. lusitaniae) in 7; and both in 3, which were fatal in 19 (90%). Fungal infections accounted for 30% of the secondary infectious events and for 55% of fatal infectious events. The only identifiable risk factors for developing a fungal infection were the degree of neutropenia and monocytopenia at initial admission or final evaluation. Invasive pulmonary aspergillosis developed despite empirical amphotericin B therapy and was associated with a high incidence of fatal pulmonary haemorrhage (10 of 13 patients). Infection was responsible for 36 (62%) of the deaths observed during the study period and haemorrhage alone for 4 (7%). However, 20 of the patients who died of infection had concomitant haemorrhage. It is concluded that invasive fungal infections, predominantly with Aspergillus and Candida, emerged in this study as the major causes of mortality in patients with aplastic anaemia. KW - aplastic anaemia KW - hosts KW - infections KW - predisposition KW - USA KW - Aspergillus KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Candida albicans KW - Candida glabrata KW - Candida lusitaniae KW - Candida tropicalis KW - Emericella nidulans KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Emericella KW - aplastic anemia KW - Aspergillus nidulans KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212361&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Localisation of hypoxanthine phosphoribosyl transferase in the malaria parasite Plasmodium falciparum. AU - Shahabuddin, M. AU - Günther, K. AU - Lingelbach, K. AU - Aikawa, M. AU - Schreiber, M. AU - Ridley, R. G. AU - Scaife, J. G. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 74 IS - 1 SP - 11 EP - 19 SN - 0014-4894 AD - Shahabuddin, M.: Malaria Section, Building 4, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920877134. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Hypoxanthine phosphoribosyl transferase of P. falciparum was located in parasites and parasite-infected erythrocytes by antibody probing. The probe was a polyclonal rabbit antiserum produced against the parasite enzyme in Escherichia coli. The enzyme was associated with membrane-bound compartments in merozoites and asexual blood parasites. In particular, indirect immunofluorescence studies showed the enzyme localised in vesicle-like structures within the cytoplasm of the infected erythrocyte. This is the first time a P. falciparum protein of defined metabolic function has been tracked to a site outside the parasite cytosol. Studies on the targeting of the enzyme using a cell-free system suggest that the protein reaches its destination via a route different from the normal secretory pathway. KW - Biochemistry KW - enzymes KW - Human diseases KW - parasites KW - Transferases KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Hypoxanthine phosphoribosyl transferase KW - location KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877134&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Entamoeba histolytica extrachromosomal circular ribosomal DNA: analysis of clonal variation in a hypervariable region. AU - Bhattacharya, S. AU - Bhattacharya, A. AU - Diamond, L. S. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 74 IS - 2 SP - 200 EP - 204 SN - 0014-4894 AD - Bhattacharya, S.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920877695. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Using a set of 4 DNA probes spanning the coding region and part of the flanking region of the E. histolytica ribosomal RNA genes, the DNA bands generated by EcoRI digestion of Entamoeba DNA was analysed. This analysis included 5 strains of E. histolytica, 4 of E. moshkovskii, and one strain each of E. invadens and E. terrapinae. No common bands were observed between E. histolytica and the other Entamoeba. Within E. histolytica, 2 bands were conserved in all strains and the others were polymorphic. Detailed analysis of DNA from independently isolated clones of the strain HM-1:IMSS of E. histolytica showed 2 bands to be highly polymorphic. Of these, the 4.4-kb band of clone 6 was further analyzed. Polymorphism in this band was even demonstrated in cells of the same clone. Restriction enzyme analysis of this DNA band from 2 clones of HM-1:IMSS showed that the polymorphism may be due to variable numbers of DraI repeat units present in this DNA stretch. KW - clonal variation KW - DNA probes KW - Human diseases KW - Molecular genetics KW - parasites KW - ribosomal DNA KW - Endamoebidae KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Endamoebidae KW - biochemical genetics KW - somatic variation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877695&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Entamoeba histolytica: is conversion of "nonpathogenic" amebae to the "pathogenic" form a real phenomenon? AU - Clark, C. G. AU - Cunnick, C. C. AU - Diamond, L. S. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 74 IS - 3 SP - 307 EP - 314 SN - 0014-4894 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878704. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Entamoeba histolytica isolates have been shown to fall into 2 groups based on isoenzyme analysis. These groupings ("pathogenic" and "nonpathogenic") correlate well with the clinical course of the infection. A controversy exists over whether isoenzyme patterns are stable or whether under certain circumstances an isolate can convert from one form to the other. Resolution of this uncertainty is of importance since the nonpathogenic pattern has never been observed in amoebae isolated from cases of active disease. This implies that, if the patterns are stable, carriers of amoebae with this nonpathogenic pattern may never develop invasive disease. In a study of isoenzyme conversion, the authors were unable to replicate the 2 published accounts of this phenomenon. They examined all of the variables proposed to be involved in the triggering of conversion, both individually and in combination. In none of the experiments was an alteration in the isoenzyme pattern observed. The authors believe that isoenzyme patterns are stable and that all available evidence, other than the reported conversions, points to pathogenic and nonpathogenic E. histolytica being distinct species.<new para>ADDITIONAL ABSTRACT:<new para>These authors had previously reported that pathogenic and nonpathogenic Entamoeba histolytica ribosomal RNA genes are distinct. Using that information they endeavoured by extensive experimentation to repeat the 2 single experiments (by different workers) that attempted to challenge zymodeme classification and stability. They now report on those 2 experiments as follows, "Although we cannot explain how Mirelman et al. [see Trop. Dis. Bull., 1987, 84, abst. 2685] and Andrews et al. [ibid., 1990, 87, abst. 2320] obtained their results, it is our opinion that they are artifactual. We now consider the pathogenic and nonpathogenic forms of Ent. histolytica as being distinct species."P.G. Sargeaunt KW - Chemotaxonomy KW - differentiation KW - Human diseases KW - Isoenzymes KW - parasites KW - pathogenicity KW - Endamoebidae KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Endamoebidae KW - biochemical taxonomy KW - isozymes KW - nonpathogenic KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878704&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of dietary fat on length of the follicular phase of the menstrual cycle in a controlled diet setting. AU - Reichman, M. E. AU - Judd, J. T. AU - Taylor, P. R. AU - Nair, P. P. AU - Jones, D. Y. AU - Campbell, W. S. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1992/// VL - 74 IS - 5 SP - 1171 EP - 1175 SN - 0021-972X AD - Reichman, M. E.: National Cancer Institute, National Institutes of Health, EPN 211, Rockville, Maryland 20892, USA. N1 - Accession Number: 19931468320. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - The length of the follicular phase of the menstrual cycle (defined as the time from the 1st day of menses until the day of urinary LH peak, inclusive) was examined in 30 healthy, premenopausal women 20-40 years old. Women consumed defined, weight maintaining diets, with a ratio of polyunsaturated to saturated fatty acids (P/S ratio) of 0.3 or 1.0. Both P/S groups consumed a high fat diet (40% energy from fat) for 4 menstrual cycles, followed by 4 menstrual cycles of a low fat diet (20% energy from fat). There was a significant increase (P<0.006) in length of the follicular phase of the menstrual cycle during consumption of the low fat diet. Two thirds of women showed increases in follicular phase length with an average increase of 1.9 days. KW - fats KW - intake KW - menstrual cycle KW - Polyunsaturated fats KW - Saturated fats KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - polyenoic fats KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468320&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tyrosine kinase activity of skeletal muscle during insulin infusion in humans. AU - Nyomba, B. L. AU - Ossowski, V. M. AU - Saad, M. F. AU - Bogardus, C. AU - Mott, D. M. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1992/// VL - 75 IS - 1 SP - 218 EP - 223 SN - 0021-972X AD - Nyomba, B. L.: Clinical Diabetes and Nutrition Section, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19941402218. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9004-10-8, 60-18-4. Subject Subsets: Human Nutrition N2 - The time course of the in vivo activation of tyrosine kinase was examined. 5 male nondiabetic Pima Indians (28±3 years old) had a euglycaemic clamp at an insulin dose of 600 mU min-1 m-1, resulting in plasma insulin values of about 15 nM by 30 min. Percutaneous muscle biopsies were taken from the vastus lateralis before and at regular intervals during insulin infusion and the in vivo and in vitro tyrosine kinase activities were measured. There was a rapid in vivo activation of the kinase, detectable at <10 min and reaching a maximum within 30 min of insulin infusion. The time course of in vivo kinase activity, plasma insulin values and insulin-mediated glucose disposal rates displayed parallel patterns, indicating close interrelations among these variables. The insulin value at which the kinase activity was maximal was about 10 nM in vivo and in vitro. In vitro, however, this maximum increased with the degree of the kinase activation in vivo, indicating that the kinase potential in vitro is dependent on previous insulin exposure in vivo. It is concluded that in vivo activation of the insulin receptor tyrosine kinase in human skeletal muscle is a rapid process, related to insulin action on glucose disposal and that circulating insulin primes inactive insulin receptor molecules for subsequent tyrosine kinase activation by a mechanism that remains to be elucidated. KW - activity KW - ethnic groups KW - infusion KW - insulin KW - kinases KW - skeletal muscle KW - tyrosine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402218&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: antibodies to circumsporozoite protein prevent sporozoites from invading the salivary glands of Aedes aegypti. AU - Warburg, A. AU - Touray, M. AU - Krettli, A. U. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 75 IS - 3 SP - 303 EP - 307 SN - 0014-4894 AD - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920801479. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - A circumsporozoite protein-specific MAb (N2H6D5) was injected into malaria-infected mosquitoes to determine its effect on the sporogonic cycle. After injection of antibody into mosquitoes (100 ng each), positive immunofluorescence (measured on air-dried sporozoites) reactions in haemolymph extracts were observed at a dilution of 1:1000. At 72 h postinjection the levels dropped to 1:10. Sporozoites coinjected with antibody did not invade the salivary glands. In naturally infected mosquitoes, sporozoites were released over a period of 3 to 4 days. Therefore, mosquitoes were injected twice. The first injection was a day before the beginning of sporozoite release and the 2nd, 2 days later. Sporozoite invasion of the salivary glands was assessed 3 days after the 2nd injection, by microscopic examination of dissected glands. At this stage, all oocysts had completed maturation and released the sporozoites. Salivary gland infections were totally prevented in mosquitoes given 2 injections of 100 ng N2H6D5. Hence, sustained presence of anti-circumsporozoite antibodies in the haemolymph can render female Aedes aegypti refractory to P. gallinaceum. KW - Antibodies KW - Circumsporozoite protein KW - Disease vectors KW - infection KW - Monoclonal antibodies KW - parasites KW - resistance KW - Salivary glands KW - Sporozoites KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - Refractoriness KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801479&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. AU - Counts, D. R. AU - Gwirtsman, H. AU - Carlsson, L. M. S. AU - Lesem, M. AU - Cutler, G. B., Jr. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1992/// VL - 75 IS - 3 SP - 762 EP - 767 SN - 0021-972X AD - Counts, D. R.: National Institutes of Health, Building 10, Room 10N262, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19931468056. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 61912-98-9, 9002-72-6. Subject Subsets: Human Nutrition N2 - The relation between serum insulin-like growth factor-I (IGF-I), IGF-II, the IGF-binding proteins IGFBP-I, IGFBP-2, and IGFBP-3, and GH-binding protein (GHBP) (which is postulated to be derived from the extracellular portion of the GH receptor) was examined in normal women and women with anorexia nervosa before and after a refeeding programme. Serum GHBP, IGF-I, and IGFBP-3 were significantly decreased in low weight patients with anorexia nervosa and returned to nearly normal values with refeeding. Fasting serum GH and serum IGFBP-1 and IGFBP-2 were significantly increased in low weight patients with anorexia nervosa and also returned to nearly normal values with refeeding. Serum IGF-II was 27% lower in the low weight group than in normal subjects, but this difference was not significant. Serum IGF-I and IGF-II were positively correlated with serum IGFBP-3 and negatively correlated with serum IGFBP-1 and IGFBP-2. Thus, it appears that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH-receptor or its postreceptor mechanisms and that this effect is reversible with refeeding. KW - anorexia nervosa KW - binding proteins KW - blood KW - insulin-like growth factor KW - refeeding KW - somatotropin KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - growth hormone KW - somatomedin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification and characterization of a Giardia lamblia group-specific gene. AU - Nash, T. E. AU - Mowatt, M. R. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 75 IS - 4 SP - 369 EP - 378 SN - 0014-4894 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930802456. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Giardia lamblia [G. duodenalis] consist of heterogeneous isolates that can be divided into at least 3 groups. Differential screening of a cDNA library with isolate-specific antisera identified a gene which is expressed and found only in Group 3 isolates. This gene, GLORF-C4, is 597 bp in length and predicts a deduced protein of 198 amino acids that is characterized by a polyserine motif. Giardia can also be grouped by their ability to express certain variant-specific surface proteins (VSPs), expression of which is restricted among groups. In Southern blots, probes specific to 2 VSPs were used to characterize isolates. Failure to detect VSP genes correlated with inability to express the same VSP. The groupings previously suggested using other criteria were confirmed.<new para>ADDITIONAL ABSTRACT:<new para>The authors have sequenced a gene, GLORF-C4, that is found only in Group 3 Giardia lamblia, and have further characterized Giardia isolates by use of DNA probes specific to 2 variant-specific surface proteins, each uniquely expressed in Giardia Groups 1 and 2. Distinguishing features for the 3 groups are summarized.Carolyn A. Brown KW - Chemotaxonomy KW - COMPLEMENTARY DNA KW - DNA libraries KW - Genes KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - Proteins KW - Strain differences KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - biochemical taxonomy KW - cDNA KW - DNA sequences KW - Giardia lamblia KW - Group 3 KW - variant specific surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802456&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a muscle-associated antigen from Wuchereria bancrofti. AU - Raghavan, N. AU - Maina, C. V. AU - Fitzgerald, P. C. AU - Tuan, R. S. AU - Slatko, B. E. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1992/// VL - 75 IS - 4 SP - 379 EP - 389 SN - 0014-4894 AD - Raghavan, N.: Laboratory of Parasitic Diseases, Building 4/Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930802457. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - A recombinant clone, WbN1, isolated from a genomic expression library of Wuchereria bancrofti and showing restricted specificity at the DNA level (Southern and PCR analyses) for W. bancrofti and Brugia malayi has been previously described. Sequence analysis of WbN1 indicated that it had notable similarity to myosin. Further characterization using in situ hybridization localized the mRNA in the muscle of the adult parasite and in the microfilariae. Rabbit polyclonal antiserum raised against the recombinant WbN1 fused to the maltose-binding protein, recognized a 200 000 MW polypeptide in immunoblots containing B. malayi antigen extracts. The same antibody also recognized myosin extracted from B. pahangi, Onchocerca volvulus and Caenorhabditis elegans. Localization using the rabbit antiserum revealed the presence of the antigen in adult muscle tissue and microfilariae; the same antibody inhibited the binding of a MAb 28.2 (directed toward MHC B of C. elegans myosin) to the recombinant WbN1 antigen and also to purified C. elegans myosin. Based on homology data, structural location, competitive ELISA, and immunoblot it is concluded that WbN1 is related to myosin or a similar myofibrillar protein. KW - antigens KW - helminths KW - Messenger RNA KW - Monoclonal antibodies KW - muscles KW - MYOSINS KW - parasites KW - Proteins KW - Recombinant proteins KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - invertebrates KW - animals KW - eukaryotes KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Wuchereria KW - Onchocercidae KW - antigenicity KW - immunogens KW - mRNA KW - myosin KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802457&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol intake in relation to lipids, lipoproteins and blood pressure. AU - Rossouw, J. E. AU - Tung, M. T. L. AU - Jooste, P. L. AU - Weight, M. J. AU - Benadé, A. J. S. JO - South African Medical Journal JF - South African Medical Journal Y1 - 1992/// VL - 82 IS - 4 SP - 246 EP - 250 SN - 0038-2469 AD - Rossouw, J. E.: Lipid Metabolism Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19941403766. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - 655 men and 731 women were studied to evaluate the association between alcohol intake, HDL cholesterol (HDL-C) and its subfractions and blood pressure in different age groups (20-44 and 45-64 years old). Habitual alcohol intake was significantly related to higher HDL-C values in men and women. In men HDL2-C and HDL3-C were increased, while in women this increase was restricted almost entirely to HDL2-C. Plasma apolipoprotein A-I and A-II were elevated in men who consumed alcohol but not in women. In men and women, triacylglycerols and blood pressure were increased with habitual alcohol intake and the increases in HDL subfractions and blood pressure became more marked with increasing age in both sexes. Recent alcohol intake had less effect on all variables except blood pressure. It is concluded that HDL3-C and HDL2-C contribute to the increase in HDL-C that accompanies alcohol intake, notwithstanding differences in responses of sexes. A regular alcohol intake is more likely to be beneficial and some of the positive or protective aspects of alcohol consumption could be reduced by adverse changes in triacylglycerol and blood pressure. KW - age KW - alcoholic beverages KW - blood KW - blood lipids KW - blood pressure KW - intake KW - lipoproteins KW - sex differences KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403766&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sources of fiber and fat in diets of US women aged 19 to 50: implications for nutrition education and policy. AU - Thompson, F. E. AU - Sowers, M. F. AU - Frongillo, E. A. AU - Parpia, B. J. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1992/// VL - 82 IS - 5 SP - 695 EP - 702 SN - 0090-0036 AD - Thompson, F. E.: Applied Research Branch, National Cancer Institute, Executive Plaza North, Room 330, Bethesda, MD 20892, USA. N1 - Accession Number: 19931458511. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - Contributions of 27 food groups to fibre, fat, saturated fat, and cholesterol intakes of 2134 women (19 to 50 years old) in USDA's Continuing Survey of Food Intakes by Individuals, the 1985 and 1986 surveys were analysed. Major determinants of fibre intake included frequency of use of certain food groups (vegetables, including potato, bread, fruit, soups, ready-to-eat cereal) and choice of particular foods within the larger food groups (e.g., whole grain bread, high fibre cereal). Major determinants of total fat, saturated fat, and cholesterol intakes included frequency of use of certain foods (sweet grains, beef, eggs, cheeses/cream, whole milks) and additions to foods (regular salad dressing and butter or margarine). Demographic characteristics were related to various food group consumption parameters. It is concluded that the relation between food group and nutrient intake and effects of household income, ethnicity, and region of residence on food group intake indicate opportunities to refine nutritional education programmes. KW - diet studies KW - fats KW - fibre KW - intake KW - Nutrition education KW - Nutrition programmes KW - sources KW - Women KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - feeding programmes KW - feeding programs KW - fiber KW - food programs KW - nutrition programs KW - United States of America KW - Animal Nutrition (Production Responses) (LL520) KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931458511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current serum levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in phenoxy acid herbicide applicators and characterization of historical levels. AU - Johnson, E. S. AU - Parsons, W. AU - Weinberg, C. R. AU - Shore, D. L. AU - Mathews, J. AU - Patterson, D. G., Jr. AU - Needham, L. L. JO - Journal of the National Cancer Institute. JF - Journal of the National Cancer Institute. Y1 - 1992/// VL - 84 IS - 21 SP - 1648 EP - 1652 AD - Johnson, E. S.: Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 19932331693. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 25168-15-4, 2545-59-7, 3813-14-7, 57213-69-1, 7173-98-0, 93-76-5, 93-79-8, 94-75-7, 94-80-4, 2008-39-1, 1929-73-3. Subject Subsets: Weeds N2 - In studies of Australian workers occupationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in preparations of 2,4,5-T and 2,4-D, serum was analysed by GC and MS to compare levels of TCDD in those workers exposed before 1965 (when concn in herbicides were unregulated and high) with those exposed after 1974 (when concn were lower due to government regulations). Mean exposure rates to TCDD were 2.7, 2.3 and 0.06 parts per trillion per month for the periods before 1965, 1965-1975 and 1975-1991, resp. The highest estimated dose was 20.7 parts per trillion, which suggested that some workers may have been exposed to levels comparable to those that produce cancer in laboratory animals. KW - 2,4,5-T KW - 2,4-D KW - application KW - chemistry KW - herbicide impurities KW - Herbicides KW - laboratory animals KW - safety KW - toxicology KW - Australia KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - (2,4,5-trichlorophenoxy)acetic acid KW - (2,4-dichlorophenoxy)acetic acid KW - weedicides KW - weedkillers KW - Pesticides and Drugs (General) (HH400) KW - Pest and Weed Control Equipment (NN430) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932331693&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant Pfs25. AU - Kaslow, D. C. AU - Bathurst, I. C. AU - Isaacs, S. N. AU - Keister, D. B. AU - Moss, B. AU - Barr, P. J. A2 - Ribeiro, C. T. D. A2 - Momen, H. JO - Memórias do Instituto Oswaldo Cruz JF - Memórias do Instituto Oswaldo Cruz Y1 - 1992/// VL - 87 IS - Suppl. III SP - 175 EP - 177 SN - 0074-0276 AD - Kaslow, D. C.: National Institute of Allergy and Infectious Diseases, Malaria Section, Laboratory of Parasitic Diseases, Building 4, Room B1-37, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805289. Publication Type: Journal Article. Language: English. N2 - The induction of Plasmodium falciparum transmission blocking antibodies by rPfs25, a cysteine-rich 25 000 MW glycolipoprotein expressed predominately in zygotes and ookinetes, is reviewed. KW - transmission blocking antibodies KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805289&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National cholesterol education program (NCEP): highlights of the report of the expert panel on blood cholesterol levels in children and adolescents. JO - Pediatrics JF - Pediatrics Y1 - 1992/// VL - 89 IS - 3 SP - 495 EP - 500 SN - 0031-4005 AD - NCEP, National Heart, Lung, and Blood Institute, Bldg 31, Room 4A05, Bethesda, MD 20892, USA. N1 - Accession Number: 19921452801. Publication Type: Journal Article. Corporate Author: USA, NCEP expert panel on blood cholesterol levels in children and adolescents Language: English. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The significance of blood cholesterol levels in childhood and adolescence is reviewed by a panel of experts. The report is published as a supplement to this issue of the journal. Highlights of the report are presented. KW - Adolescents KW - blood KW - Children KW - cholesterol KW - heart diseases KW - reviews KW - risk KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - coronary diseases KW - teenagers KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921452801&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. AU - Kopp, J. B. AU - Klotman, M. E. AU - Adler, S. H. AU - Bruggeman, L. A. AU - Dickie, P. AU - Marinos, N. J. AU - Eckhaus, M. AU - Bryant, J. L. AU - Notkins, A. L. AU - Klotman, P. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1992/// VL - 89 IS - 5 SP - 1577 EP - 1581 SN - 0027-8424 AD - Kopp, J. B.: Laboratory of Developmental Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920194922. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - By using a non-infectious human immunodeficiency-virus type 1 (HIV-1) DNA construct lacking the gag and pol genes, 3 transgenic mouse lines have been generated that develop a syndrome similar to the human disease. In this study, one of these lines, Tg26 was studied in detail. In Tg26 mice, proteinuria was detectable at approx. 24 days of age, followed by severe nephrotic syndrome and rapid progression to end-stage renal failure. Renal histology showed focal segmental glomerulosclerosis and microcystic tubular dilatation. Indirect immunofluorescence studies demonstrated increased accumulation of the basement membrane components laminin, collagen type IV and heparan sulphate proteoglycan. The viral protein Rev was present in sclerotic glomeruli. Northern blot analysis of total renal RNA showed expression of viral genes prior to the appearance of histological renal disease, with greatly diminished viral gene expression late in the disease course. Kidneys from transgenic mice expressed increased steady-state levels of collagen α1(IV) mRNA when glomerulosclerosis was present. It is concluded that the presence of HIV-1 genes is associated with progressive renal dysfunction and glomerulosclerosis in transgenic mice. KW - Animal models KW - Biotechnology KW - damage KW - gene expression KW - Gene transfer KW - Genetic engineering KW - genetically engineered organisms KW - human immunodeficiency viruses KW - kidneys KW - Pathology KW - renal failure KW - transgenic animals KW - transgenics KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic manipulation KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - Glomeruli KW - GMOs KW - Human immunodeficiency virus KW - kidney failure KW - Murine KW - transgenic mice KW - transgenic organisms KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920194922&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses. AU - Pletnev, A. G. AU - Bray, M. AU - Huggins, J. AU - Lai ChingJuh JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1992/// VL - 89 IS - 21 SP - 10532 EP - 10536 SN - 0027-8424 AD - Pletnev, A. G.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930518258. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - Dengue type 4 virus (DEN4) cDNA was used as a vector to express genes of the distantly related tick-borne encephalitis virus (TBEV). Full-length chimaeric TBEV/DEN4 cDNAs were constructed by substituting TBEV genes coding for proteins such as capsid (C); pre-membrane, which is the precursor of membrane (M); envelope (E); or nonstructural protein NS1 for the corresponding DEN4 sequences. RNA transcripts prepared from cDNAs were used to transfect permissive simian cells. 2 viable chimaeric viruses that contained TBEV CME or ME genes were recovered. Compared with DEN4, chimaeric TBE(ME)/DEN4 virus (designated vTBE(ME)/DEN4) produced larger plaques and grew to higher titre in simian cells. In contrast, vTBE(ME)/DEN4 produced smaller plaques on Aedes albopictus C6/36 mosquito cells and grew to lower titre than DEN4. Analysis of viral RNA and proteins produced in vTBE(ME)/DEN4- and DEN4-infected mosquito or simian cells revealed that the chimaera was restricted in its ability to enter and replicate in mosquito cells. In contrast, vTBE(ME)/DEN4 entered simian cells efficiently and its RNA was replicated more rapidly in these cells than was parental DEN4 RNA. Following intracerebral inoculation, vTBE(ME)/DEN4 caused fatal encephalitis in both suckling and adult mice, while nearly all mice inoculated by the same route with DEN4 did not develop disease. Unlike wild-type TBEV, vTBE(ME)/DEN4 did not cause encephalitis when adult mice were inoculated by a peripheral route. Adult mice previously inoculated with the chimaera by a peripheral route were completely resistant to subsequent intraperitoneal challenge with 10³ times the median lethal dose of TBEV, whereas mice previously inoculated with DEN4 were not protected. These findings indicate that the TBEV M and E genes of the chimaeric virus are major protective antigens and induce resistance to lethal TBEV challenge, and that other regions of the TBEV genome are essential for the ability of this virus to spread from a peripheral site to the brain. Success in constructing a viable TBEV/DEN4 chimaera that retains the protective antigens of TBEV but lacks its peripheral invasiveness provides a strategy for the development of live attenuated TBEV vaccines.<new para>ADDITIONAL ABSTRACT:<new para>Dengue type 4 virus (DEN4) cDNA was used as a vector to express genes of the distantly related tick-borne encephalitis virus (TBEV). Full-length chimeric TBEV/DEN4 cDNA were constructed by substituting TBEV genes coding for proteins such as capsid (C); pre-membrane, which is the precursor of membrane (M); envelope (E); or nonstructural protein NS1 for the corresponding DEN4 sequences. RNA transcripts prepared from cDNAs were used to transfect permissive simian cells. Two viable chimeric viruses that contained TBEV CME or ME genes were recovered. Compared with DEN4, chimeric TBE(ME)/DEN4 virus [designated vTBE(ME)/DEN4] produced larger plaques and grew to higher titer in simian cells. In contrast, vTBE(ME)/DEN4 produced smaller plaques on mosquito cells and grew to lower titer than DEN4. Analysis of viral RNA and proteins produced in vTBE(ME)/DEN4- and DEN4-infected mosquito or simian cells revealed that the chimera was restricted in its ability to enter and replicate in mosquito cells. In contrast, vTBE(ME)/DEN4 entered simian cells efficiently and its RNA was replicated more rapidly in these cells than was parental DEN4 RNA. Following intracerebral inoculation, vTBE(ME)/DEN4 caused fatal encephalitis in both suckling and adult mice, while nearly all mice inoculated by the same route with DEN4 did not develop disease. Unlike wild-type TBEV, vTBE(ME)/DEN4 did not cause encephalitis when adult mice were inoculated by a peripheral route. Adult mice previously inoculated with the chimera by a peripheral route were completely resistant to subsequent intraperitoneal challenge with 10³ times the median lethal dose of TBEV, whereas mice previously inoculated with DEN4 were not protected. These findings indicate that (i) the TBEV M and E genes of the chimeric virus are major protective antigens and induce resistance to lethal TBEV challenge and (ii) other regions of the TBEV genome are essential for the ability of this virus to spread from a peripheral site to the brain. Success in constructing a viable TBEV/DEN4 chimera that retains the protective antigens of TBEV but lacks its peripheral invasiveness provides a strategy for the development of live attenuated TBEV vaccines.AS KW - arboviruses KW - cell lines KW - chimaeras KW - gene expression KW - genetic engineering KW - vaccines KW - viral diseases KW - viral proteins KW - Aedes albopictus KW - Culicidae KW - dengue 4 virus KW - dengue virus KW - Flavivirus KW - mice KW - Tick-borne encephalitis virus KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - arthropod-borne viruses KW - Asian tiger mosquito KW - Central European encephalitis virus KW - chimeras KW - genetic manipulation KW - mosquitoes KW - neurovirulence KW - tickborne encephalitis virus KW - viral infections KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518258&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lower sedentary metabolic rate in women compared with men. AU - Ferraro, R. AU - Lillioja, S. AU - Fontvieille, A. M. AU - Rising, R. AU - Bogardus, C. AU - Ravussin, E. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1992/// VL - 90 IS - 3 SP - 780 EP - 784 SN - 0021-9738 AD - Ferraro, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Room 541, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19941402319. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - 24-h energy expenditure (24EE), basal metabolic rate (BMR) and sleeping metabolic rate (SMR) were measured in a respiratory chamber in healthy, nondiabetic Caucasian subjects (114 males, 34±14 years old; 121 females, 38±17 years old). Body composition was estimated by hydrodensitometry. 24EE was 124±38 kcal/day (P<0.002) higher in males than females after adjusting for differences in fat-free mass, fat mass and age. Spontaneous physical activity was not significantly different between males and females. Since adjusted 24EE was 106±39 kcal/day (P<0.01) higher in females during the luteal phase of the menstrual cycle compared with females during the follicular phase, energy expenditure was analysed in subjects >50 years old to minimize the confounding effect of menstrual status. 24EE (160±66; P<0.03), BMR (116±45; P<0.02), and SMR (208±68 kcal/day; P<0.005) were higher in males compared with females >50 years old after adjusting for differences in body composition, age and activity. It is indicated that sedentary 24EE is about 5-10% lower in females compared with males after adjusting for differences in body composition, age and activity. KW - body composition KW - comparisons KW - energy exchange KW - men KW - metabolism KW - obesity KW - resting energy exchange KW - sex differences KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402319&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoid protection against X-ray-induced chromatid damage in human peripheral blood lymphocytes. AU - Sanford, K. K. AU - Parshad, R. AU - Price, F. M. AU - Tarone, R. E. AU - Kraemer, K. H. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1992/// VL - 90 IS - 5 SP - 2069 EP - 2074 SN - 0021-9738 AD - Sanford, K. K.: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19931462115. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition N2 - X-ray induced chromatid damage in phytohaemagglutinin-stimulated blood lymphocytes from 5 xeroderma pigmentosa (XP) patients receiving isotretinoin was about half that in blood samples from the same patients before and subsequent to treatment. The X-ray induced chromatid damage in blood lymphocytes from a normal control was reduced significantly by cocultivation with blood plasma from an XP patient receiving isotretinoin or by addition of 10-6M isotretinoin to cultures 1 h before X-irradiation. A similar reduction in X-ray-induced chromatic damage was reported previously by adding to the culture medium mannitol, a scavenger of the free hydroxyl radical, or catalase, which decomposes hydrogen peroxide. Both of these products are generated during ionizing radiation. These observations suggest that isotretinoin acts as a scavenger of such radiation products, thereby providing protection against X-ray induced chromatic damage. KW - chromatids KW - Free radicals KW - lymphocytes KW - radiation protection KW - retinoids KW - Skin diseases KW - X radiation KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dermatoses KW - vitamin A compounds KW - X rays KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462115&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Community-based evaluation of the effect of breast-feeding on the risk of microbiologically confirmed or clinically presumptive shigellosis in Bangladeshi children. AU - Ahmed, F. AU - Clemens, J. D. AU - Rao, M. R. AU - Sack, D. A. AU - Khan, M. R. AU - Haque, E. JO - Pediatrics JF - Pediatrics Y1 - 1992/// VL - 90 IS - 3 Part 1 SP - 406 EP - 411 SN - 0031-4005 AD - Ahmed, F.: (J. D. Clemens), Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Plaza Building, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020252. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - To assess the association between breast-feeding and the risk of microbiologically confirmed or clinically presumptive shigellosis, the authors performed a case-control analysis of Bangladeshi children younger than 3 years of age who were followed up for 1 month after exposure to Shigella in their residential neighborhoods. Two hundred sixty-nine cases with culture-confirmed shigellosis (n = 119) or clinically presumptive shigellosis (culture-negative dysentery, n = 150) were compared with 819 controls without Shigella diarrhea or other invasive diarrheal illnesses. The odds ratio relating breast-feeding to confirmed or presumptive shigellosis, adjusted for potentially confounding variables, was 0.48 (95% confidence interval = 0.32 to 0.72; P <0.001), suggesting a substantial protective effect. The protective association decreased with age but was still significant during the third year of life; appeared to be directly related to the degree of stunting; and was equivalent for confirmed and presumptive shigellosis. Notably, the protective association remained substantial against episodes due to Shigella which were resistant to at least one of the antibiotics customarily used for treatment of Shigella diarrhea (age-adjusted odds ratio = 0.40; 95% confidence interval = 0.22 to 0.74; P <0.01). These data suggest that breast-feeding confers a high level of protection against shigellosis throughout the first 3 years of life, especially among nutritionally compromised children, and thereby underscore the importance of promotion of breast-feeding as a central component of Shigella control programs in less developed settings. AS KW - breast KW - breast feeding KW - children KW - feeding KW - infants KW - shigellosis KW - Asia KW - Bangladesh KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - South Asia KW - Asia KW - breasts KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020252&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food sources of energy, macronutrients, cholesterol, and fiber in diets of women. AU - Krebs-Smith, S. M. AU - Cronin, F. J. AU - Haytowitz, D. B. AU - Cook, D. A. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1992/// VL - 92 IS - 2 SP - 168 EP - 174 SN - 0002-8223 AD - Krebs-Smith, S. M.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931459752. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Potatoes N2 - Data from the 1985 Continuing Survey of Food Intakes by Individuals in the USA were used to calculate the contributions of individual foods to women's intakes of energy, protein, carbohydrate, fat, saturated fatty acids, cholesterol and fibre. Nearly all food mixtures were separated into their constituent ingredients, the ingredients were grouped with similar foods, and the contributions of those foods were examined. Yeast breads that were neither whole-grain nor higher-fibre contributed about 7% of the energy to the diets, which made them the leading source of energy of the foods examined. The leading sources of protein were animal products: poultry contributed about 12%, beef about 19%, cheese about 8% and pork about 6%. The various fats and oils were the greatest contributors to fat, and cheese was the chief source of saturated fatty acids. Eggs were the major source of cholesterol, providing around 36% of the total. Two of the top 3 sources of carbohydrate, regular soft drinks and sugar, are composed entirely of simple sugars. Potatoes provided around 11% of the fibre, which made them the leading source of fibre. The relative ranking of foods and the contribution of each food depend on the way food codes are combined. Therefore, citing one food as the major source of a particular food component without including documentation of how foods are combined can be misleading. KW - fibre KW - intake KW - nutrients KW - Nutrition KW - sources KW - Women KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fiber KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459752&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparative evaluation of fibric acid derivatives and HMG-CoA reductase inhibitors. AU - Brewer, H. B. JO - Atherosclerosis JF - Atherosclerosis Y1 - 1992/// VL - 97 IS - Suppl. SP - S11 EP - S19 SN - 0021-9150 AD - Brewer, H. B.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19931463042. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9004-02-8, 503-49-1. Subject Subsets: Human Nutrition N2 - A review. Fibric acid derivatives (fibrates) and β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are hyperlipaemic agents with contrasting mechanisms of action. By increasing the activity of lipoprotein lipase, fibrates exert a pronounced triacylglycerol-lowering effect, which, however, varies with the nature of the underlying lipid abnormality. Reductase inhibitors are the most potent cholesterol-lowering drugs available. By inhibiting HMG-CoA reductase these agents induce a compensatory increase in the synthesis and expression of hepatic low density lipoprotein (LDL) receptors, resulting in reduction of plasma LDL. There is also evidence that reductase inhibitors inhibit the synthesis of LDL and apolipoprotein B. This action may be especially beneficial in patients with combined hyperlipaemia with overproduction of LDL and apo B. Reductase inhibitors also reduce triacylglycerol values, but to a lesser extent than LDL, and this effect is not as marked as that of fibrates. LDL is regarded as the principal atherogenic lipoprotein and preference may therefore be given to reductase inhibitors in lipid regulation for prevention of coronary heart disease. Fibrates, however, offer advantages in the management of patients with predominant or exclusive hypertriglyceridaemia. KW - drug therapy KW - Enzyme inhibitors KW - Hypercholesterolaemia KW - Hyperlipaemia KW - Hypertriglyceridaemia KW - Lipoprotein lipase KW - meglutol KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 3-hydroxy-3-methylglutaric acid KW - chemotherapy KW - diacylglycerol lipase KW - hypercholesterinemia KW - hypercholesterolemia KW - hyperlipemia KW - hypertriglyceridemia KW - Pesticides and Drugs (General) (HH400) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931463042&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Binding of tricyclic antidepressant drugs to trophozoites of Giardia lamblia. AU - Weinbach, E. C. AU - Levenbook, L. AU - Alling, D. W. JO - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology JF - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology Y1 - 1992/// VL - 102 IS - 3 SP - 391 EP - 396 SN - 0306-4492 AD - Weinbach, E. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930802520. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology N2 - Parameters affecting the binding of the tricyclic drugs imipramine and 3-chlorimipramine to G. lamblia [G. duodenalis] trophozoites (Portland 1 strain, ATCC 3088) were studied. Two to 3 times more chlorimipramine than imipramine was bound, consistent with a similar difference in suppressing parasite growth. Kinetic analysis and the ease with which bound drugs can be washed out of the parasites is thought to indicate that noncovalent forces are involved in the drug-parasite interaction. Evidence is presented that such drugs probably bind to parasite protein at common binding sites. The data relate to an earlier observation that chlorimipramine is about 10 times more effective than metronidazole in suppressing G. lamblia growth in vitro. It is thought that tricyclic drugs, therefore, merit serious consideration as novel therapeutic agents against giardiasis. KW - Antidepressants KW - Antiprotozoal agents KW - Developmental stages KW - in vitro KW - mode of action KW - parasites KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - 3-chlorimipramine KW - growth phase KW - imipramine KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduction of pulmonary surfactant in patients with human immunodeficiency virus infection and Pneumocystis carinii pneumonia. AU - Hoffman, A. G. D. AU - Lawrence, M. G. AU - Ognibene, F. P. AU - Suffredini, A. F. AU - Lipschik, G. Y. AU - Kovacs, J. A. AU - Masur, H. AU - Shelhamer, J. H. JO - Chest JF - Chest Y1 - 1992/// VL - 102 IS - 6 SP - 1730 EP - 1736 SN - 0012-3692 AD - Hoffman, A. G. D.: Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19930883396. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology N2 - Both qualitative and quantitative differences in surfactant lipid composition of bronchoalveolar lavage (BAL) fluid in patients with AIDS and Pneumocystis carinii pneumonia (PCP) were assessed. BAL was carried out on 5 normal volunteers and 27 patients in the National Institutes of Health, Maryland, USA, with HIV infection. BAL studies were positive for P. carinii in 19 patients. Total lipid profiles of dephosphorylated glycerolipids were analyzed by high temperature gas-liquid chromatography. Phospholipase A2 levels were determined using a radiolabelled E. coli method. Compared to the normal volunteers and the P. carinii negative patients, total BAL lipid was reduced in patients with PCP. There was a parallel reduction for diacylglycerol lipids. Phospholipase A2 activity in moderate to severe PCP patients was twice that of the P. carinii negative patients, and 30 times that for normal volunteers. The data demonstrate a marked diminution in surfactant glycerophospholipids in patients with AIDS and PCP and suggest a potential role for surfactant abnormality in the pathophysiology of this disease. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - bronchoalveolar lavage KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pathology KW - pneumonia KW - respiratory diseases KW - surfactants KW - Maryland KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - fungus KW - glyceropholipids KW - human immunodeficiency virus KW - lung diseases KW - surface active agents KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Measurements of iron status in patients with chronic hepatitis. AU - Bisceglie, A. M. di AU - Axiotis, C. A. AU - Hoofnagle, J. H. AU - Bacon, B. R. JO - Gastroenterology JF - Gastroenterology Y1 - 1992/// VL - 102 IS - 6 SP - 2108 EP - 2113 SN - 0016-5085 AD - Bisceglie, A. M. di: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. N1 - Accession Number: 19941403979. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - Patients with chronic viral hepatitis (67 men, 13 women; 94% of patients were white) were screened for evidence of iron overload. Elevated serum Fe values were noted in 36% of cases; serum ferritin values were above normal in 30% of men and 8% of women. Additional patients with chronic hepatitis (22 men, 6 women; 86% of patients were white) for whom liver tissue was available for estimation of Fe content were evaluated to study the significance of Fe overload in association with chronic hepatitis. Although 46% had elevated serum Fe, ferritin or transferrin-saturation levels, hepatic Fe concentration was elevated in only 4 cases and the hepatic Fe index was in the range for hereditary haemochromatosis (>2.0) in only 2 of these. Serum aspartate aminotransferase activities correlated with serum ferritin levels in these patients, suggesting that ferritin and Fe levels were increased in serum because of their release from hepatocellular stores associated with necrosis. Thus, in patients with chronic hepatitis in whom hereditary haemochromatosis is suspected, a liver biopsy should be performed with quantitation of hepatic Fe and calculation of hepatic Fe index to confirm the diagnosis. KW - haemochromatosis KW - hepatitis KW - iron KW - liver KW - mineral metabolism disorders KW - nutritional state KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hemochromatosis KW - iron storage disease KW - nutritional status KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403979&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. AU - Shinohara, T. AU - Kikuchi, T. AU - Tsuda, M. AU - Yamaki, K. JO - Comparative Biochemistry and Physiology. B, Comparative Biochemistry JF - Comparative Biochemistry and Physiology. B, Comparative Biochemistry Y1 - 1992/// VL - 103 IS - 3 SP - 505 EP - 509 AD - Shinohara, T.: Molecular Biology Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930518476. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology KW - agricultural entomology KW - animal physiology KW - antigens KW - biochemistry KW - genes KW - genetics KW - molecular genetics KW - photoreceptors KW - reviews KW - vision KW - arthropods KW - cattle KW - Diptera KW - Drosophila KW - Drosophilidae KW - insects KW - man KW - mice KW - rats KW - invertebrates KW - animals KW - eukaryotes KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - insects KW - Hexapoda KW - arthropods KW - Drosophilidae KW - Diptera KW - Homo KW - Hominidae KW - Primates KW - Muridae KW - rodents KW - antigenicity KW - arrestins KW - biochemical genetics KW - immunogens KW - sight KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518476&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection and disease in lymphatic filariasis: an immunological perspective. AU - Ottesen, E. A. JO - Parasitology JF - Parasitology Y1 - 1992/// VL - 104 IS - Suppl. SP - S71 EP - S79 SN - 0031-1820 AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930878442. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 36 ref. Subject Subsets: Helminthology N2 - The basic tenet of the immunological perspective of filarial disease is that differential immune responsiveness among individuals exposed to infection results in the different clinical manifestations that develop. The mechanisms involved in this differential responsiveness appear to reflect different T-cell cytokine response patterns. Asymptomatic patients with the clinically silent presentation of 'asymptomatic microfilaraemia', who have been previously described as being 'immunosuppressed' with respect to their generating pro-inflammatory (Th1-type) immune responses to parasite antigen, are now recognized to be fully responsive to parasite antigen but to produce cytokines and mediators that have primarily anti-inflammatory (Th2-like) effects. Studies with immunodeficient mice have indicated the existence of 2 alternative pathways to the development of lymphatic pathology: one dependent on the induction of inflammatory reactions by the host immune response, the other entirely independent of the immune system and reflecting the direct actions of the parasite or its products on the lymphatics. As histopathology of affected human lymphatics is consistent with this hypothesis, it may be that the lymphatic pathology seen normally in the amicrofilaraemic, highly immunoresponsive infected patients derives from inflammation induced by immune responses to parasite antigen, whereas the lymphatic pathology sometimes seen coexisting with the 'immunosuppressed' state of asymptomatic microfilaraemia actually reflects lymphatic damage that is not immunologically mediated. Though little information exists about the 'natural history' of lymphatic filariasis, there is no evidence for an inevitable progression from one clinical form to another. Instead, there appears to be a definite plasticity in the response that depends on prior (? pre-natal) and current exposure to the parasite as well as on the immunodulatory effects it induces. This plasticity does not appear to be complete, however, as there is no evidence that a chronically infected host who has developed strong pro-inflammatory immune responses can subsequently become sufficiently 'down-regulatory' to support an asymptomatic microfilaraemia type of infection. Another possible constraint to the plasticity of the clinical and immunological responses may be the genetic determination of certain unusual syndromes, such as tropical pulmonary eosinophilia or TPE, though this hypothesis remains to be proven. KW - Filariasis KW - Filariids KW - helminths KW - Human diseases KW - immunology KW - Lymphatic filariasis KW - parasites KW - reviews KW - Brugia malayi KW - Brugia timori KW - man KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Wuchereria KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930878442&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome. AU - Lopez, J. S. AU - Smet, M. D. de AU - Masur, H. AU - Mueller, B. U. AU - Pizzo, P. A. AU - Nussenblatt, R. B. T2 - American Journal of Ophthalmology JO - American Journal of Ophthalmology JF - American Journal of Ophthalmology Y1 - 1992/// VL - 113 IS - 3 SP - 331 EP - 333 SN - 0002-9394 AD - Lopez, J. S.: National Eye Institute, Bldg. 10, Rm. 10N226, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920800982. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 95233-18-4. Subject Subsets: Protozoology N2 - A 14-year-old haemophiliac boy with AIDS developed Toxoplasma gondii-induced retinochoroiditis in his right eye. The disease progressed despite pyrimethamine treatment (50 mg twice daily). Sulfadiazine and clindamycin were also given but were discontinued after causing allergic rashes. When the patient was referred to the National Institutes of Health, Maryland, USA, his visual acuity was 20/200 in his right eye. Ocular examination disclosed a localized area of vitritis over an ill-defined, superotemporal retinochoroidal infiltrate in the right eye. This lesion was adjacent to an old retinochoroidal scar and extended to the superior border of the disc with surrounding retinal oedema and a macular star. Anti-Toxoplasma IgG titre was 4.29 by ELISA. 566C80 was administered orally at a dose of 750 mg 4 times daily. On the 4th day of therapy, there was a significant resolution of the vitreal inflammation, which resulted in a clearer delineation of the macular star and adjacent subretinal haemorrhage. By 4 weeks, visual acuity improved to 20/40. There was no sign of recurrence at the 5-month follow-up and no adverse reactions to 566C80 were recognized. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Antiprotozoal agents KW - atovaquone KW - Children KW - drug therapy KW - Eyes KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - Toxoplasmosis KW - Maryland KW - North America KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - chemotherapy KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800982&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combined use of cyclosporine and ketoconazole in the treatment of endogenous uveitis. AU - Smet, M. D. de AU - Rubin, B. I. AU - Whitcup, S. M. AU - Lopez, J. S. AU - Austin, H. A. AU - Nussenblatt, R. B. JO - American Journal of Ophthalmology JF - American Journal of Ophthalmology Y1 - 1992/// VL - 113 IS - 6 SP - 687 EP - 690 SN - 0002-9394 AD - Smet, M. D. de: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931213731. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 79217-60-0, 65277-42-1. Subject Subsets: Medical & Veterinary Mycology N2 - Patients (n=10) with endogenous uveitis were in clinical remission attributable to treatment with cyclosporin and prednisone. After the cyclosporin dose was reduced by two-thirds, these patients were randomly assigned to treatment with or without ketoconazole, a potent inhibitor of cytochrome P-450, in a double-masked placebo-controlled study. The dose was reduced over 3 d. During a 3-month follow-up, no patients treated with ketoconazole had a relapse of uveitis, while 4 of 6 (66%) control subjects had a flare-up. Toxicity in the ketoconazole-treated group was limited to a transient decrease in glomerular filtration rate (20% from baseline) at 1 month in 2 of 6 (33%) patients. Renal function was stabilized by further reduction of the cyclosporin dose. KW - antagonism KW - Antifungal agents KW - cyclosporins KW - Ketoconazole KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931213731&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An unusually high prevalence of ocular toxoplasmosis in Southern Brazil. AU - Glasner, P. D. AU - Silveira, C. AU - Kruszon-Moran, D. AU - Martins, M. C. AU - Burnier, M, Jr. AU - Silveira, S. AU - Camargo, M. E. AU - Nussenblatt, R. B. AU - Kaslow, R. A. AU - Belfort, R, Jr. JO - American Journal of Ophthalmology JF - American Journal of Ophthalmology Y1 - 1992/// VL - 114 IS - 2 SP - 136 EP - 144 SN - 0002-9394 AD - Glasner, P. D.: Epidemiology and Biometry Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803045. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 308067-58-5. Subject Subsets: Protozoology N2 - A population-based household survey was performed to evaluate the epidemiology of ocular toxoplasmosis in Rio Grande do Sul because of the frequency of this disease and its occurrence in multiple siblings in southern Brazil. Of 1042 individuals examined, 184 (17.7%) were found to have ocular toxoplasmosis and, of these, 183 (99.5%) had specific IgG antibodies, compared with only 140 (77.4%) from 181 age-matched controls. The prevalence of ocular toxoplasmosis was 0.9% in 1-8 year-olds, 4.3% in 9-12 year-olds, 14.3% in 13-16 year-olds, and 21.3% in all individuals older than 13 years. The prevalence of ocular toxoplasmosis in this population was more than 30 times higher than previous estimates for the same condition elsewhere. The low prevalence in the youngest children supports the hypothesis that, in this population, ocular toxoplasmosis is a sequel to post-natal infection rather than a congenital infection. KW - children KW - epidemiology KW - eye diseases KW - IgG KW - parasites KW - toxoplasmosis KW - Brazil KW - Rio Grande do Sul KW - man KW - protozoa KW - Toxoplasma gondii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Brazil KW - prevalence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803045&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gastrointestinal infections in AIDS. A2 - Smith, P. D. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1992/// VL - 116 IS - 1 SP - 63 EP - 77 SN - 0003-4819 AD - National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211476. Publication Type: Journal Article. Language: English. Number of References: 168 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - An edited summary of a Clinical Staff Conference on gastrointestinal infections in AIDS patients held at National Institutes of Health, Maryland, is presented. Diagnostic evaluation is discussed, followed by viral pathogens, fungal infections (Candida albicans and Histoplasma capsulatum), protozoan infections (Cryptosporidium, Isospora belli, Enterocytozoon bieneusi, Entamoeba histolytica, Giardia lamblia and Blastocystis hominis) and bacterial infections. Mechanisms of mucosal immunity in relation to AIDS, role of humoral immunity in the response to intestinal pathogens and therapeutic strategies for enteric infections in HIV-infected patients are also included. KW - acquired immune deficiency syndrome KW - digestive tract KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - infections KW - Opportunistic infections KW - parasites KW - predisposition KW - Candida albicans KW - Histoplasma capsulatum KW - man KW - Protozoa KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Histoplasma KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - invertebrates KW - AIDS KW - Ajellomyces capsulatus KW - fungus KW - gastrointestinal tract KW - human immunodeficiency virus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211476&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Itraconazole-digoxin interaction. AU - Rex, J. T2 - Annals of Internal Medicine JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1992/// VL - 116 IS - 6 SP - 525 EP - 525 SN - 0003-4819 AD - Rex, J.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211690. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 20830-75-5, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 68-yr-old man with Sporothrix schenckii osteoarthritis of the right elbow, who failed to respond to saturated solution of KI or ketoconazole. The patient was receiving digoxin (0.25 mg bid) and ibuprofen for atrial fibrillation. After 2 wks of itraconazole treatment (400 mg/d), the patient developed nausea and fatigue, which was shown to be due to itraconazole, and digoxin levels rose. It is concluded that the addition of itraconazole to this patient's previously stable digoxin regimen produced signs and symptoms of digoxin toxicity along with an elevated digoxin level. Satisfactory digoxin levels were achieved on 25% of the patient's original dose of digoxin. KW - antagonism KW - Antifungal agents KW - digoxin KW - hosts KW - infections KW - itraconazole KW - joints (animal) KW - therapy KW - USA KW - man KW - Sporothrix schenckii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential localization of Acanthamoeba myosin I isoforms. AU - Baines, I. C. AU - Brzeska, H. AU - Korn, E. D. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1992/// VL - 119 IS - 5 SP - 1193 EP - 1203 SN - 0021-9525 AD - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804802. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology N2 - Acanthamoeba castellanii myosins IA and IB were localized by immunofluorescence and immunoelectron microscopy in vegetative and phagocytosing cells and the total cell contents of myosins IA, IB and IC were quantified by immunoprecipitation. The quantitative distributions of the 3 myosin I isoforms were then calculated from these data and from the previously determined localization of myosin IC. Myosin IA occurs almost exclusively in the cytoplasm, where it accounts for ~50% of the total myosin I, in the cortex beneath phagocytic cups and in association with small cytoplasmic vesicles. Myosin IB is the predominant isoform associated with the plasma membrane, large vacuole membranes and phagocytic membranes and accounts for almost half of the total myosin I in the cytoplasm. Myosin IC accounts for a significant fraction of the total myosin I associated with the plasma membrane and large vacuole membranes and is the only myosin I isoform associated with the contractile vacuole membrane. These data suggest that myosin IA may function in cytoplasmic vesicle transport and myosin I-mediated cortical contraction, myosin IB in pseudopod extension and phagocytosis, and myosin IC in contractile vacuole function. In addition, endogenous and exogenously added myosins IA and IB appeared to be associated with the cytoplasmic surface of different subpopulations of purified plasma membranes implying that the different myosin I isoforms are targeted to specific membrane domains through a mechanism that involves more than the affinity of the myosins for anionic phospholipids. KW - biochemistry KW - myosins KW - parasites KW - proteins KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - isoforms KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804802&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Maternal vitamin levels during pregnancies producing infants with neural tube defects. AU - Mills, J. L. AU - Tuomilehto, J. AU - Yu, K. F. AU - Colman, N. AU - Blaner, W. S. AU - Koskela, P. AU - Rundle, W. E. AU - Forman, M. AU - Toivanen, L. AU - Rhoads, G. G. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1992/// VL - 120 IS - 6 SP - 863 EP - 871 SN - 0022-3476 AD - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, DESPR, National Institute of Child Health and Human Development, National Institute of Health, EPN Bldg., Room 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19931461509. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition N2 - Folate, vitamin B12 and retinol levels were estimated in maternal serum drawn early in 89 pregnancies resulting in neural tube defects (NTD) offspring and 178 control pregnancies identified from the Finnish Registry of Congenital Malformations. In 86.5% of the subjects, specimens were collected within 8 weeks after neural tube closure. In the NTD case mothers the mean (±SD) levels were not significantly lower than in controls: folate, 4.13±2.36 vs. 4.28±2.52 ng/ml; vitamin B12, 482.8±161.1 vs. 520.3±191.9 pg/ml; and retinol, 51.2±17.0 vs. 50.5±16.9 µg/100 ml. After adjustment for age of the specimen, gestational age at which the specimen was drawn, maternal age and maternal employment status, the odds ratios for being a case mother were 1.00 (95% confidence interval (CI) 0.91 to 1.10) for folate, 1.05 (95% CI 0.92 to 1.19) for vitamin B12 and 0.99 (95% CI 0.88 to 1.10) for retinol. Excluding NTD cases with known or suspected causes unrelated to vitamins, restricting the analyses to interviewed subjects, and excluding subjects whose specimens were collected after 15 gestational weeks confirmed that NTD case and control vitamin levels did not differ significantly. This population-based investigation in a low rate area demonstrated no relationship between maternal serum folate, vitamin B12, or retinol levels during pregnancy and the risk of NTDs. KW - Congenital abnormalities KW - nervous system KW - nutritional state KW - pregnancy KW - vitamins KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - birth defects KW - congenital malformations KW - gestation KW - nutritional status KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461509&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety and pharmacokinetics of fluconazole in children with neoplastic diseases. AU - Lee, J. W. AU - Seibel, N. L. AU - Amantea, M. AU - Whitcomb, P. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1992/// VL - 120 IS - 6 SP - 987 EP - 993 SN - 0022-3476 AD - Lee, J. W.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931214969. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - The safety, tolerance and pharmacokinetics of fluconazole was evaluated in 26 children (13 boys, 13 girls, aged 5-15 yr) receiving treatment for cancer. Intravenous fluconazole was given for a 2 h period, in doses of 2, 4 or 8 mg/kg daily for 7 d. No nausea or vomiting related to fluconazole was reported. An asymptomatic rise in hepatic aminotransferase values was seen in 3 patients after 4-6 doses (1 patient at 2 mg/kg and 2 at 8 mg/kg daily) which returned to normal within 2 wk of discontinuation of the drug. Fluconazole showed linear first-order kinetics over the dosage range tested and during multiple dosing. After the 1st dose, mean clearance was 22.8±2.3 ml/min, volume of distribution 0.8±0.06 litre/kg and terminal elimination half-life 16.8±1.1 h and after the last dose, these values were 19.4±1.3 ml/min, 0.84±0.04 litre/kg and 18.1±1.2 h, respectively. After a 1st dose of 8 mg/kg, peak and trough serum levels achieved 24 h later were 9.5±0.4 and 2.7±0.5 µg/ml, respectively, and an area under the serum concn-time from time zero to infinity of 186±16 µg/h per ml was achieved. Renal clearance of fluconazole was 65±5% of total clearance and demonstrated the predominantly renal excretion of this drug. KW - Antifungal agents KW - children KW - Fluconazole KW - pharmacokinetics KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fungistats KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214969&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium avium-intracellulare infection. AU - Lewis, L. L. AU - Butler, K. M. AU - et al. AU - Husson, R. N. ( JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1992/// VL - 121 IS - 5 SP - 677 EP - 683 SN - 0022-3476 AD - Lewis, L. L.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942024160. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - [The authors] reviewed the 22 cases of Mycobacterium avium-intracellulare (MAI) infection that occurred among 196 human immunodeficiency virus-infected children seen at the National Cancer Institute Pediatric Branch from December 1986 through April 1991, and an additional 65 charts from children with cultures negative for MAI. All patients with proven MAI were receiving antiretroviral therapy with zidovudine, dideoxyinosine, or a combination of zidovudine and dideoxycytidine. All patients had disseminated MAI infection, except one adolescent who had only evidence of localized lymphadenitis. All cases of MAI but one were diagnosed before death. The overall incidence of MAI was 11% in [the] patients but increased to 24% in patients whose absolute CD4 cell counts were <100 cells/mm³. Symptoms most commonly associated with MAI infection included recurrent fever (86% of patients), weight loss or failure to thrive (64%), neutropenia (55%), night sweats (32%), and abdominal pain (27%). Children infected with MAI had a mean CD4 percentage of 2% (range, 0% to 7%) and a mean absolute CD4 count of 12 cells/mm³ (range, 0 to 48 cells/mm³), significantly lower than in the remainder of the clinic population or the group of children with cultures negative for MAI. Of 20 patients with MAI infection who were tested, 10 had measurable p24 antigen with a mean value 939 pg/ml (range, 77 to 3270 pg/ml) compared with 19 of 59 patients without MAI infection in whom the mean positive value was 413 pg/ml. There was no difference in survival time between those children with documented MAI infection (median survival time, 45.5 weeks) and those with similarly low CD4 counts and cultures negative for MAI (median survival time, 50.4 weeks). Future improvements in therapeutic options may make screening of pediatric human immunodeficiency virus-infected patients with low CD4 counts a reasonable plan. AS KW - human immunodeficiency viruses KW - infections KW - risk factors KW - North America KW - USA KW - Mycobacterium KW - Mycobacterium avium complex KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - bacterium KW - HUMAN IMMUNODEFICIENCY VIRUS KW - infections Mycobacterium aviumminusintracellulare KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942024160&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combination treatment with azidothymidine and granulocyte colony-stimulating factor in children with human immunodeficiency virus infection. AU - Mueller, B. U. AU - Jacobsen, F. AU - Butler, K. M. AU - Husson, R. N. AU - Lewis, L. L. AU - Pizzo, P. A. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1992/// VL - 121 IS - 5 SP - 797 EP - 802 SN - 0022-3476 AD - Mueller, B. U.: (P.A. Pizzo) Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005936. Publication Type: Journal Article. Language: English. Registry Number: 30516-87-1. KW - Combination therapy KW - HIV infections KW - Neutropenia KW - Paediatrics KW - Treatment KW - Zidovudine KW - AZT KW - combined modality therapy KW - Granulocyte colony stimulating factor KW - human immunodeficiency virus infections KW - multimodal treatment KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005936&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - OxyR: a regulator of antioxidant genes. AU - Storz, G. AU - Tartaglia, L. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1992/// VL - 122 IS - 3S SP - 627 EP - 630 SN - 0022-3166 AD - Storz, G.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Bethesda, MD 20817, USA. N1 - Accession Number: 19921446206. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - The study of the bacterial response to hydrogen peroxide has given general insights into how cells defend against deleterious oxidants. Treatment of Salmonella typhimurium and Escherichia coli cells with low doses of hydrogen peroxide results in the induction of 30 proteins and resistance to killing by higher doses of hydrogen peroxide. The expression of 9 of the hydrogen peroxide-inducible proteins, including the antioxidant enzymes catalase, glutathione reductase and an alkyl hydroperoxide reductase, is controlled by the positive regulator oxyR. Strains carrying deletions of the oxyR gene are hypersensitive to hydrogen peroxide and have increased levels of spontaneous mutagenesis during aerobic growth. The OxyR protein is homologous to the LysR-NodD family of bacterial regulatory proteins and binds to the promoters of oxyR-regulated genes. The oxidized, but not the reduced, form of the OxyR protein activates transcription of oxyR-regulated genes in vitro, suggesting that direct oxidation of the OxyR protein brings about a confirmation change by which OxyR senses an oxidative stress signal and then activates the expression of defense activities. KW - Antioxidants KW - genes KW - regulation KW - reviews KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446206&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of a model for selenite metabolism in humans. AU - Patterson, B. H. AU - Zech, L. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1992/// VL - 122 IS - 3S SP - 709 EP - 714 SN - 0022-3166 AD - Patterson, B. H.: Biometry Branch, Executive Plaza North, Suite 344, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19921446268. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - The process of building a kinetic model for the metabolism of selenite in man is described. Plasma, urine and faecal data from a selenium pharmacokinetics study are compared with an a priori model hypothesized before the study was conducted. The reasons for the rejection of the model are given. The iterative process of observing the fit of the model, modifying the model and testing the modification is illustrated by using as examples an intermediate model and a current working model. Several specific problems encountered in trying to fit the a priori and the intermediate model are described along with the approaches taken to resolve them. Finally, some uses of the current model are given, including checking an assumption underlying the pharmacokinetics study, making predictions about the effect of supplementation on plasma values and developing research leads. KW - mathematical models KW - metabolism KW - reviews KW - Selenium KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921446268&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nonparticipation as a determinant of adverse health outcomes in a field trial of oral cholera vaccines. AU - Clemens, J. D. AU - Loon, F. F. P. L. van AU - et al. AU - Sack, D. A. ( JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1992/// VL - 135 IS - 8 SP - 865 EP - 874 SN - 0002-9262 AD - Clemens, J. D.: Prevention Research Program, National Institute of Child Health and Human Development, Executive Plaza North Building, Room 640, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020120. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - The authors estimated the incidence rates of cholera and death between 1985 and 1988 for 32 642 age- and sex-eligible persons who did not participate in a randomized, placebo-controlled field trial of killed oral cholera vaccines in rural Bangladesh. As compared with 20 744 placebo recipients, the relative risk of cholera for all nonparticipants, adjusted for potentially confounding demographic variables, was 1.20 (95% confidence interval (CI) 1.03-1.41); this adjusted relative risk reflected elevated adjusted relative risks in nonparticipants who were medically ineligible (RR = 1.65; 95% CI 1.22-2.22) or refused to participate (RR = 1.19; 95% CI 1.01-1.41), but not in persons absent at the time of vaccination (RR = 1.00; 95% CI 0.78-1.28). The adjusted relative risk of death was also elevated in nonparticipants as compared with placebo recipients (RR = 1.28; 95% CI 1.10-1.48), with the same pattern of adjusted relative risks for different categories of nonparticipants: for ineligible subjects, 2.64 (95% CI 2.12-3.29); for refusers, 1.20 (95% CI 1.02-1.41); and for absentees, 0.95 (95% CI 0.75-1.22). The authors concluded that nonparticipation was associated with clinically cogent adverse health outcomes, but that the magnitude of these associations varied according to the reason for nonparticipation. These findings underscore the caution required in assessing vaccine efficacy with controls who are not vaccinated because of choices made by patients or vaccinators. AS KW - Cholera KW - immunization KW - mouth KW - trials KW - vaccines KW - Asia KW - Bangladesh KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - South Asia KW - Asia KW - cooperative behaviour KW - immune sensitization KW - killed KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020120&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet and other risk factors for laryngeal cancer in Shanghai, China. AU - Zheng, W. AU - Blot, W. J. AU - Shu, X. O. AU - Gao, Y. T. AU - Ji, B. T. AU - Ziegler, R. G. AU - Fraumeni, J. F., Jr. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1992/// VL - 136 IS - 2 SP - 178 EP - 191 SN - 0002-9262 AD - Zheng, W.: National Cancer Institute, Executive Plaza North, Room 431, Bethesda, MD 20892, USA. N1 - Accession Number: 19931454756. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - A population-based, case-control study of laryngeal cancer was conducted in Shanghai, China, during 1988-1990, in which 177 males and 24 females diagnosed as having laryngeal cancer and 269 males and 145 females (controls) were interviewed. Cigarette smoking was the major risk factor, accounting for 86% of the male and 54% of the female cases. After adjusting for smoking, there was little increase in risk associated with drinking alcoholic beverages. Among men, cases more often reported occupational exposures to asbestos and coal dust. A protective effect was associated with the intake of fruits (particularly oranges and tangerines), some dark green/yellow vegetables, and garlic, but there was an increased risk with the intake of salt-preserved meat and fish. Results suggest that risk factors for laryngeal cancer in Shanghai resemble those in Western countries, and they provide further evidence that dietary factors have an important aetiologic role. KW - alcoholic beverages KW - Carcinoma KW - diet KW - larynx KW - China KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - People's Republic of China KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931454756&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - How much of the recent rise in breast cancer incidence can be explained by increases in mammography utilization? A dynamic population model approach. AU - Feuer, E. J. AU - Wun, L. M. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1992/// VL - 136 IS - 12 SP - 1423 EP - 1436 SN - 0002-9262 AD - Feuer, E. J.: Division of Cancer Prevention and Control, National Cancer Institute, EPN 313, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020723. Publication Type: Journal Article. Language: English. N2 - The authors developed a model that is based on that by White et al. (Journal of the National Cancer Institute 1990; 82: 1546-52) that incorporate estimates of differential lead time by age group. This model shows that if older women have longer lead times, some mammography usage across age groups will result in a larger increase in older womens' incidence. Therefore, the increases in mammography usage are in accord with increases in incidence, across all age groups.Danielle Horton. KW - age groups KW - breast cancer KW - human diseases KW - mammary gland neoplasms KW - neoplasms KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - mammary tumour KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020723&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. AU - Shu, X. O. AU - Zheng, W. AU - et al. AU - Potischman, N. ( AU - Brinton, L. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1992/// VL - 137 IS - 2 SP - 155 EP - 165 SN - 0002-9262 AD - Shu, X. O.: (L.A. Brinton) Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020725. Publication Type: Journal Article. Language: English. KW - neoplasms KW - China KW - Shanghai KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Eastern China KW - China KW - cancers KW - People's Republic of China KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020725&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Small subunit ribosomal RNA of Blastomyces dermatitidis: sequence and phylogenetic analysis. AU - Geber, A. AU - Higgins, D. E. AU - Waters, A. P. AU - Bennett, J. E. AU - McCutchan, T. F. JO - Journal of General Microbiology JF - Journal of General Microbiology Y1 - 1992/// VL - 138 IS - 2 SP - 395 EP - 399 SN - 0022-1287 AD - Geber, A.: Laboratory of Clinical Investigation and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211133. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology; Agricultural Biotechnology N2 - The small subunit (18S) ribosomal RNA sequence of B. dermatitidis was determined. The sequence was compared with that of 14 other eukaryotic organisms, 10 of which were higher fungi, and an evolutionary tree was constructed based on these sequences. B. dermatitidis aligned most closely with the ascomycetes Neurospora crassa and Podospora anserina, in agreement with previous phylogenetic analysis based on morphological criteria. Phase-specific cDNA clone derived by reverse transcription of RNA isolated from the yeast and mycelial phases of B. dermatitidis were also sequenced. The 18S ribosome sequence was found to be the same in both phases. Heterogeneity was found at both the genomic and RNA level at position 1352. KW - Biotechnology KW - genetics KW - nucleotide sequences KW - Ribosomal DNA KW - ribosomal RNA KW - taxonomy KW - Blastomyces dermatitidis KW - Blastomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - DNA sequences KW - fungus KW - rRNA KW - systematics KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211133&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a genomic group of Borrelia burgdorferi through signature nucleotide analysis and 16S rRNA sequence determination. AU - Marconi, R. T. AU - Garon, C. F. JO - Journal of General Microbiology JF - Journal of General Microbiology Y1 - 1992/// VL - 138 IS - 3 SP - 533 EP - 536 SN - 0022-1287 AD - Marconi, R. T.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515927. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology N2 - As part of a continuing effort to assess genetic variation among isolates of B. burgdorferi, the 16S rRNA signature nucleotide makeup of 2 tick (Ixodes persulcatus) isolates from Russia were determined. Signature nucleotides were identified via reverse transcriptase primer extension sequencing of select regions of the 16S rRNA molecule. In addition, the near complete 16S rRNA sequence of one of the isolates, R-IP3, was determined and utilized in a phylogenetic assessment. The sequence was aligned with the 16S rRNA sequences of other B. burgdorferi isolates, as well as with other Borrelia species (B. anserina, B. coriaceae, B. hermsii). Distance matrix analyses were performed and a phylogenetic tree was constructed. These analyses demonstrated that these isolates belong to a third previously unidentified genomic group of B. burgdorferi. KW - genome analysis KW - molecular genetics KW - Nucleotide sequences KW - Ribosomal RNA KW - Russia KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - bacterium KW - biochemical genetics KW - DNA sequences KW - rRNA KW - Russian Federation KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515927&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The molecular analysis of synonymy among medically important yeasts within the genus Candida. AU - Wickes, B. L. AU - Hicks, J. B. AU - Merz, W. G. AU - Kwon-Chung, K. J. JO - Journal of General Microbiology JF - Journal of General Microbiology Y1 - 1992/// VL - 138 IS - 5 SP - 901 EP - 907 SN - 0022-1287 AD - Wickes, B. L.: K. J. Kwon-Chung, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921211854. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Three sets of medically important yeasts, C. albicans, C. tropicalis and C. krusei, were compared with their putative synonyms (C. langeronii and C. claussenii, C. paratropicalis, and Itssatchenkia orientalis, respectively) to determine if these synonyms are genetically distinguishable from each other. Pulsed-field electrophoresis and hybridization to species-specific probes were used. The species-specific probes for C. albicans and C. tropicalis have been previously described (27A and CT13.8, respectively) whereas the probe for C. krusei (CK3) was cloned. No distinguishing characteristics between synonyms were identified, supporting the current taxonomic treatment of these organisms. KW - Biotechnology KW - molecular biology KW - taxonomy KW - Candida acidothermophilum KW - Candida albicans KW - Candida tropicalis KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida krusei KW - fungus KW - Hyphomycetes KW - systematics KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211854&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cystitis induced by infection with the Lyme disease spirochete, Borrelia burgdorferi, in mice. AU - Czub, S. AU - Duray, P. H. AU - Thomas, R. E. AU - Schwan, T. G. JO - American Journal of Pathology JF - American Journal of Pathology Y1 - 1992/// VL - 141 IS - 5 SP - 1173 EP - 1179 SN - 0002-9440 AD - Czub, S.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Hamilton, MT 59840, USA. N1 - Accession Number: 19940805925. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - Previous studies have shown that the urinary bladder is a consistent source for isolating B. burgdorferi from both experimentally infected and naturally exposed rodents. In this study, histopathological changes in the urinary bladder were examined in a variety of rodents experimentally infected with B. burgdorferi. Spirochaetes were cultured from the urinary bladder of all 35 mice inoculated with low-passaged spirochaetes, but none were cultured from the kidneys of the same mice. The pathological changes observed most frequently in the urinary bladder were the presence of lymphoid aggregates, vascular changes and thickening of the vessel walls. The results demonstrated that 93% of the animals examined had a cystitis associated with spirochaetal infection. KW - bladder KW - cystitis KW - Lyme disease KW - pathology KW - Borrelia burgdorferi KW - mice KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - lyme borreliosis KW - urinary bladder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805925&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pulmonary involvement in loiasis. AU - Klion, A. D. AU - Eisenstein, E. M. AU - Smirniotopoulos, T. T. AU - Neumann, M. P. AU - Nutman, T. B. JO - American Review of Respiratory Disease JF - American Review of Respiratory Disease Y1 - 1992/// VL - 145 IS - 4,I SP - 961 EP - 963 SN - 0003-0805 AD - Klion, A. D.: T.B. Nutman, National Institutes of Health, Laboratory of Parasitic Diseases, Bldg. 4, Rm. 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878275. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Helminthology N2 - A 40-year-old Ghanaian man was admitted to hospital in Maryland, USA, with acute pleural effusion. Cytological evaluation of the pleural fluid revealed Loa loa microfilariae. No additional aetiology for the pleural effusion could be identified, and antifilarial treatment with diethylcarbamazine (a 50-mg test dose followed by an increase in dose gradually over 4 days to 8 mg/kg/day in 3 divided doses) led to a rapid resolution of the patient's symptoms and pulmonary abnormalities. It is considered that Loa loa must be considered as a treatable cause of eosinophilic pleural effusions in persons from endemic areas of West and Central Africa. KW - Case reports KW - Eosinophilia KW - helminths KW - Human diseases KW - Imported infections KW - Loiasis KW - Lungs KW - parasites KW - Pleura KW - Africa KW - Ghana KW - Maryland KW - North America KW - USA KW - Loa loa KW - man KW - Nematoda KW - Onchocercidae KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - African eyeworm KW - loaosis KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878275&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnosis of Pneumocystis carinii pneumonia by multiple lobe, site-directed bronchoalveolar lavage with immunofluorescent monoclonal antibody staining in human immunodeficiency virus-infected patients receiving aerosolized pentamidine chemoprophylaxis. AU - Levine, S. J. AU - Kennedy, D. AU - Shelhamer, J. H. AU - Kovacs, A. AU - Feuerstein, I. M. AU - Gill, V. J. AU - Stock, F. AU - Solomon, D. AU - Boylen, C. T. AU - Masur, H. AU - Ognibene, F. P. JO - American Review of Respiratory Diseases JF - American Review of Respiratory Diseases Y1 - 1992/// VL - 146 IS - 4 SP - 838 EP - 843 AD - Levine, S. J.: Critical Care Medicine Department, Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920801046. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology N2 - The yields of both induced sputum examination and bronchoalveolar lavage (BAL) have been reported to be decreased for breakthrough episodes of P. carinii pneumonia in HIV-infected patients receiving aerosolized pentamidine chemoprophylaxis. This study assessed whether the yield of a single middle or lower lobe BAL could be increased by the utilization of 2 techniques: indirect immunofluorescent staining with a combinate of 2 murine monoclonal anti-Pneumocystis antibodies in addition to routine toluidine blue O and cytopathologic staining, and the performance of multiple lobe, site-directed BAL (i.e., both upper lobe and middle or lower lobe lavage, including the lobe with the greatest radiographic abnormality). Results of 252 fiberoptic bronchoscopies performed at the National Institutes of Health, Maryland and the Los Angeles County-University of Southern California Medical Center were analyzed. P. carinii pneumonia was documented in 21 episodes in patients who did not receive prior anti-Pneumocystis chemoprophylaxis and in 41 episodes in patients who received aerosolized pentamidine. MAb staining and multiple lobe, site-directed BAL resulted in similar diagnostic yields for P. carinii in the nonprophylaxis (100%) and aerosolized pentamidine (98%) groups. If BAL had been performed without MAb staining and multiple lobe, site-directed lavage, than the yield would have decreased to 95% in the nonprophylaxis group and to 80% in the aerosolized pentamidine group. When the yields for single middle or lower lobe BAL without MAb staining and multiple lobe, site-directed BAL with MAb staining were compared in patients receiving aerosolized pentamidine, the sensitivity was significantly improved when both supplemental techniques were used (98% versus 80%). These data suggest that the use of both immunofluorescent MAB staining and multiple lobe, site-directed BAL. In addition to middle or lower lobe lavage and conventional staining techniques, can maintain the high positive yield of BAL for P. carinii in patients receiving aerosolized pentamidine chemoprophylaxis. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Bronchoalveolar lavage KW - diagnosis KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - immunodiagnosis KW - Monoclonal antibodies KW - Opportunistic infections KW - parasites KW - Staining KW - California KW - Maryland KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - South Atlantic States of USA KW - Southern States of USA KW - AIDS KW - fungus KW - human immunodeficiency virus KW - serological diagnosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801046&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. AU - Gazzinelli, R. T. AU - Oswald, I. P. AU - James, S. L. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 148 IS - 6 SP - 1792 EP - 1796 SN - 0022-1767 AD - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930807498. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 130068-27-8. Subject Subsets: Helminthology; Protozoology N2 - It was shown that interleukin-10 (IL-10) (which is produced by Th2 CD4+ T lymphocytes) can down-regulate IFN-γ-dependent immunity by blocking the ability of that lymphokine to activate macrophages. Thus, IL-10, in a dose-dependent manner, inhibited the microbicidal activity of IFN-γ-treated inflammatory macrophages against intracellular Toxoplasma gondii (RH strain) and the extracellular killing of schistosomula of Schistosoma mansoni. This suppression correlated with the inhibition by IL-10 of IFN-γ-induced production of toxic nitrogen oxide metabolites, an effector mechanism previously implicated in the killing by macrophages of both parasite targets. IL-10 inhibition of nitric oxide production was shown to occur when the cytokine was given before or together with the IFN-γ-activating stimulus, but not after the cells had been previously activated, and to require 12 h of contact for maximal suppressive effect on macrophage function. These results, taken together with previous findings on the down-regulation of Th1 lymphokine production by IL-10, indicate that the induction of IL-10 may be an important strategy by which parasites evade IFN-γ-dependent, cell-mediated immune destruction. KW - Cytokines KW - helminths KW - Human diseases KW - Immunology KW - immunosuppression KW - in vitro KW - interleukin 10 KW - macrophages KW - parasites KW - Apicomplexa KW - Digenea KW - protozoa KW - Sarcocystidae KW - Schistosoma mansoni KW - Schistosomatidae KW - Toxoplasma gondii KW - Trematoda KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Trematoda KW - Platyhelminthes KW - Eucoccidiorida KW - Apicomplexa KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Toxoplasma KW - Sarcocystidae KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807498&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment with anti-IL2 antibodies reduces hepatic pathology and eosinophilia in Schistosoma mansoni-infected mice while selectively inhibiting T cell IL-5 production. AU - Cheever, A. W. AU - Finkelman, F. D. AU - Caspar, P. AU - Heiny, S. AU - Macedonia, J. G. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 148 IS - 10 SP - 3244 EP - 3248 SN - 0022-1767 AD - Cheever, A. W.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879291. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Helminthology N2 - In vivo treatment of S. mansoni (NMRI strain) infected C3H/HeN female mice with anti-IL-2 antibodies, with or without anti-IL-2 receptor antibodies, significantly diminished the size of circumoval granulomas in the liver and decreased hepatic fibrosis to half that in untreated mice. Antibody treated animals also displayed a marked reduction in both peripheral blood and tissue eosinophilia while IgE levels were unchanged or increased. Spleen cell cytokine production in response to antigen or mitogen stimulation was selectively altered by in vivo anti-IL2 administration. IL-5 responses were dramatically reduced, whereas IL-4, IL-2, and IFN-γ responses were not consistently changed. These findings confirm previous observations, suggesting a role for IL-2 in egg-induced pathology but indicate that the primary function of this cytokine in schistosome-infected mice may be in the generation of Th2- rather than Th1-associated responses. KW - Cytokines KW - Eosinophils KW - Granuloma KW - helminths KW - Human diseases KW - immunopathology KW - Interleukins KW - Laboratory animals KW - parasites KW - T lymphocytes KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - eosinophil leukocytes KW - immunopathogenesis KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879291&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parallel regulation of IL-4 and IL-5 in human helminth infections. AU - Mahanty, S. AU - Abrams, J. S. AU - King, C. L. AU - Limaye, A. P. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 148 IS - 11 SP - 3567 EP - 3571 SN - 0022-1767 AD - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802603. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 37341-29-0, 308067-57-4, 148641-02-5, 207137-56-2. Subject Subsets: Helminthology N2 - To investigate the relationship between cytokine production and the increased levels of serum IgE and peripheral eosinophilia commonly accompanying human helminth infections, the ability of PMBC of normal (N1) (n = 18) and eosinophilic individuals with helminth infections (H1) (n = 9) to produce IL-3, Il-4, IL-5, granulocyte-macrophage-CSF, and IFN-γin vitro after stimulation with PMA (50 ng/ml) and ionomycin (1 µg/ml) was investigated. The 2 groups differed in both the levels of serum IgE and eosinophilia. In H1, 4 were infected wih Loa loa, one with Strongyloides, 3 with Onchocerca volvulus and one had lymphatic filariasis. For mitogen-induced production of granulocyte-macrophage-CSF and IFN-γ, there was no difference in cytokine production between the 2 groups. In marked contrast, supernatants from PBMC of infected individuals had significantly higher levels of IL-4 (mean = 213 pg/ml for N1 and 944 pg/ml for H1), IL-5 (mean = 180 pg/ml for N1 and 1118 pg/ml for HL), and IL-3 (mean = 13 900 pg/ml for N1, 28 029 pg/ml for H1). In addition, helminth-infected patients had ~5-fold greater numbers of T cells capable of producing IL-5 and 2.5-fold greater frequency of IL-4-secreting cells than did normal individuals; GM-CSF- and IFN-γ-producing T cell numbers were not significantly different in the 2 groups. IL-3-producing cell frequencies could not be evaluated by this method. There was a direct correlation between IL-4 production and IL-5 production at the level of both protein production and frequency of T cells capable of producing these cytokines. The data indicated that individuals with reactive eosinophilia and elevated serum IgE have an expanded population of lymphocytes producing IL-4 and IL-5 and the association of the 2 suggests that the regulation of IL-4 and IL-5 may be linked. KW - Cytokines KW - Eosinophils KW - Helminths KW - Human diseases KW - IgE KW - immune response KW - Immunoglobulins KW - Interleukin 3 KW - Interleukin 4 KW - Interleukin 5 KW - parasites KW - T lymphocytes KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - eosinophil leukocytes KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - reagin KW - reaginic antibodies KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802603&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. AU - Oswald, I. P. AU - Gazzinelli, R. T. AU - Sher, A. AU - James, S. L. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 148 IS - 11 SP - 3578 EP - 3582 SN - 0022-1767 AD - Oswald, I. P.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802605. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 130068-27-8, 207137-56-2. Subject Subsets: Helminthology N2 - After activation with IFN-γ, thioglycollate-elicited murine peritoneal macrophages kill schistosomula of Schistosoma mansoni in vitro by an L-arginine-dependent mechanism which involves the production of reactive nitrogen oxides (NO). In this study it was shown that the regulatory cytokines IL-10, IL-4, and transforming growth factor-β (TGF-β) are potent inhibitors of this extracellular killing function of activated macrophages. Each cytokine was found to suppress killing of schistosomula in a dose-dependent fashion. The activity of IL-10 was not permanent, because subsequent treatment with additional IFN-γ 2 to 6 h later reversed the inhibition of macrophage larval killing. More importantly, the combination of suboptimal levels of any 2 of these 3 cytokines was found to give a potent synergistic suppression of schistosomulum killing by IFN-γ-treated macrophage. Similarly, IL-10, IL-4, or TGF-β alone blocked the production of NO, and when used in combination these cytokines exhibited an enhanced inhibitory effect on nitrite production. Macrophage-mediated killing of schistosomula through the generation of NO has been shown previously to be a major effector mechanism of schistosome immunity. The results presented suggest that the suppression of this mechanism by induction of the regulatory cytokines IL-10, IL-4 and TGF-β, which are known to be produced during schistosome infection, may be an important strategy used by the parasite to evade macrophage-mediated immune destruction. KW - Cytokines KW - helminths KW - Human diseases KW - Immune evasion KW - in vitro KW - Interleukin 10 KW - Interleukin 4 KW - macrophages KW - parasites KW - Digenea KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802605&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. AU - Gazzinelli, R. AU - Xu, Y. H. AU - Hieny, S. AU - Cheever, A. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 149 IS - 1 SP - 175 EP - 180 SN - 0022-1767 AD - Gazzinelli, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879475. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology N2 - C57BL/6 mice chronically infected with an avirulent strain (ME-49) of T. gondii were used to study the mechanisms by which T lymphocytes and IFN-γ prevent reactivation of latent infection. Infected animals were treated with MAbs either anti-CD8, anti-CD4, anti-CD4 plus anti-CD8, anti-IFN-γ, or anti-CD4 plus anti-IFN-γ. Treatment with anti-IFN-γ antibodies fully reactivated the asymptomatic infection, inducing massive necrotic areas in the brain with the appearance of free tachyzoites and death of all animals within 2 weeks. Mice treated with the combination of anti-CD4 plus anti-CD8 antibodies showed augmented pathology and mortality nearly identical to the anti-IFN-γ-treated animals. In contrast, treatment with anti-CD4 or anti-CD8 MAb alone failed to result in significantly enhanced brain pathology or mortality. In additional experiments, full reactivation of infection was observed in mice treated with anti-CD4 plus anti-IFN-γ indicating that CD4+ lymphocytes are not required for the pathology resulting from IFN-γ neutralization. Cytokine measurements on parasite antigen (Ag)-stimulated spleen cells from MAb-treated mice indicated that both CD4+ and CD8+ cells produce IFN-γ whereas only CD4+ cells contribute to parasite Ag-induced IL-2 synthesis. Together, these results suggest that CD4+ and CD8+ lymphocytes act additively or synergistically to prevent reactivation of chronic T. gondii infection probably through the production of IFN-γ. KW - Human diseases KW - Immunocompromised hosts KW - Laboratory animals KW - Monoclonal antibodies KW - Opportunistic infections KW - parasites KW - resistance KW - T lymphocytes KW - Apicomplexa KW - mice KW - Muridae KW - protozoa KW - Rodents KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1. AU - Hosmalin, A. AU - Kumar, S. AU - Barnd, D. AU - Houghten, R. AU - Smith, G. E. AU - Hughes, S. H. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 149 IS - 4 SP - 1311 EP - 1318 SN - 0022-1767 AD - Hosmalin, A.: J.A. Berzofsky, Metabolism Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 6B-12, Bethesda, MD 20892, USA. N1 - Accession Number: 19920800117. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Protozoology N2 - Cytotoxic T lymphocyte (CTL) lines specific for 2 different proteins derived from P. falciparum circumsporozoite protein and HIV-1 reverse transcriptase, were obtained by immunizing C3H/HeN mice with protein-pulsed syngeneic spleen cells. The lysis of the target cells was dependent on a class I MHC molecule and the accessory molecule CD8. Immunodominant epitopic peptides were identified previously in the 2 proteins using murine CTL derived after immunization with recombinant virus or sporozoites, or using CTL from HIV-1-infected patients. These peptides were also recognized by the CTL lines obtained after protein-pulsed spleen-cell immunization. A new CTL antigenic determinant was localized in HIV-1 reverse transcriptase to residues 514 to 528, a sequence that, if folded as an α-helix, would be strongly amphipathic. The determinant was tentatively narrowed, using overlapping peptides, to a core of a least 9 residues, 515 to 523. This site was also recognized by CTL obtained by the 3 different methods of immunization. Therefore, extracellular proteins incubated with spleen cells can be processed and presented in vivo in the same way as intracellular proteins, resulting in recognition of the same epitopes in association with the same class I MHC molecules. The potential implications for vaccine development and for the understanding of class I-restricted antigen presentation are discussed. KW - Circumsporozoite protein KW - Cytotoxic T lymphocytes KW - Human diseases KW - immunization KW - Laboratory animals KW - parasites KW - T lymphocytes KW - Vaccines KW - Apicomplexa KW - mice KW - Muridae KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - immune sensitization KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical and immunologic characterization of a major IgE-inducing filarial antigen of Brugia malayi and implications for the pathogenesis of tropical pulmonary eosinophilia. AU - Lobos, E. AU - Ondo, A. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1992/// VL - 149 IS - 9 SP - 3029 EP - 3034 SN - 0022-1767 AD - Lobos, E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920801530. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 37341-29-0. Subject Subsets: Helminthology N2 - A major allergen of B. malayi was identified by 2-dimensional immunoblot analysis using a serum pool from patients with tropical pulmonary eosinophilia. The allergen is composed of 2 antigens of 23 000 and 25 000 MW and acidic isoelectric point (Bm23-25). Immunoblots using affinity-purified IgE antibodies to BM23-25 indicated that Bm23-25 is expressed mainly in the microfilarial stage. Digestion of the allergen with endoglycosidases indicates that it has N-linked oligosaccharide chains. Analysis of the reactivity of T cells derived from patients with lymphatic filariasis revealed that the Bm23-25 allergen was capable of stimulating T cell proliferation; Bm23-25 was also shown to induce IgE production in vitro from peripheral blood mononuclear cells derived from patients with either tropical pulmonary eosinophilia (TPE) or other filarial symptoms. Bronchoalveolar lavage fluid of patients with TPE contained IgE antibodies that recognized Bm23-25 strongly, an observation suggesting that the microfilarial allergen might be involved in the pathogenesis of the TPE syndrome. KW - antigens KW - Filariids KW - helminths KW - Human diseases KW - IgE KW - parasites KW - pathogenesis KW - T lymphocytes KW - Brugia malayi KW - man KW - Nematoda KW - Onchocercidae KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - antigenicity KW - immunogens KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - Spirurida KW - T cells KW - Tropical pulmonary eosinophilia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801530&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Belgrade virus: a new hantavirus causing severe haemorrhagic fever with renal syndrome in Yugoslavia. AU - Gligic, A. AU - Dimkovic, N. AU - et al. AU - Xiao, S. Y. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 1 SP - 113 EP - 120 SN - 0022-1899 AD - Gligic, A.: (R. Yanagihara) National Institutes of Health, Bldg. 36, Rm. 5B-21, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020556. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1-3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30 000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.AS KW - blood KW - haemorrhagic fever with renal syndrome KW - haemorrhagic fevers KW - patients KW - urine KW - Europe KW - Yugoslavia KW - Balkans KW - Southern Europe KW - Europe KW - Mediterranean Region KW - Belgrade virus KW - hemorrhagic fever with renal syndrome KW - hemorrhagic fevers KW - Jugoslavia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020556&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). AU - Levine, P. H. AU - Jahan, N. AU - Murari, P. AU - Manak, M. AU - Jaffe, E. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 2 SP - 291 EP - 295 SN - 0022-1899 AD - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bldg. EPN, Rm. 434, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020438. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - After preliminary serologic data demonstrated elevated antibody titers to human herpesvirus (HHV) 6 in patients with sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease, tissues were examined from 9 patients with classical SHML to search for evidence of HHV-6 infection. Involved tissues from 7 of the 9 patients had detectable HHV-6 by in situ hybridization: tissue from 1 had detectable Epstein-Barr virus genome but no HHV-6 and tissue from another had no detectable HHV-6 or Epstein-Barr virus. These studies suggest that HHV-6 and, to a lesser extent, Epstein-Barr virus may be involved in the etiology of SHML. AS KW - viral diseases KW - Herpesviridae KW - human herpesvirus 6 KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Roseolovirus KW - Betaherpesvirinae KW - RosaiminusDorfman disease KW - RosaiminusDorfman disease patients KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020438&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - UV light-induced reactivation of herpes simplex virus type 2 and prevention by acyclovir. AU - Rooney, J. F. AU - Straus, S. E. AU - et al. AU - Mannix, M. L. ( AU - Notkins, A. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 3 SP - 500 EP - 506 SN - 0022-1899 AD - Rooney, J. F.: (A.L. Notkins) Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Building 30, Room 121, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021182. Publication Type: Journal Article. Language: English. Registry Number: 59277-89-3. Subject Subsets: Public Health KW - aciclovir KW - Herpes simplex KW - latent infections KW - prevention KW - Human herpesvirus 2 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - acyclovir KW - herpes simplex virus 2 KW - reactivation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021182&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multistate outbreak of hepatitis A associated with frozen strawberries. AU - Niu, M. T. AU - Polish, L. B. AU - et al. AU - Robertson, B. H. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 3 SP - 518 EP - 524 SN - 0022-1899 AD - Niu, M. T.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021185. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Public Health N2 - "A multistate outbreak of hepatitis A was traced to frozen strawberries processed at a single plant. Among 827 students and 60 teachers at an elementary school in Georgia [USA] during a 2-week period, 15 developed hepatitis A. Three months later, among 174 residents and 467 staff in an institution for the developmentally disabled in Montana during a 3-week period, 13 developed hepatitis A. Primary attack rates were 10% in the school and 8% in the institution. Cohort analysis in the school implicated consumption of strawberry shortcake in hepatitis A virus (HAV) infection (relative risk, 7.6; 95% confidence interval, 1.04-55.6). In the institution, such analysis implicated desserts and uncooked strawberries as the most biologically plausible vehicle of HAV transmission. Molecular analysis of HAV from patients in the 2 outbreaks revealed that the viral genomes were genetically identical and distinct from other known US strains. Contamination of food products before retail distribution is rare but should be considered in investigating common-source outbreaks of hepatitis A". Empty frozen strawberry containers found in both institutions came from the same company in California which was investigated retrospectively. Strawberries were washed in chlorinated water (but this is not significant to remove traces of fecal contamination). Contact with public health authorities in states where implicated lots of strawberries had been distributed elicited no reports of unexplained food-borne outbreaks of hepatitis A in 1988-90. No outbreaks in the strawberry field workers had been reported.D.W. FitzSimons KW - Food KW - foodborne diseases KW - hepatitis KW - hepatitis A KW - strawberries KW - Georgia KW - USA KW - Fragaria KW - viruses KW - Rosaceae KW - Rosales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southeastern States of USA KW - America (North) KW - United States of America KW - Food Science and Food Products (Human) (QQ000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021185&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans: augmentation by granulocyte colony-stimulating factor and interferon-γ. AU - Roilides, E. AU - Uhlig, K. AU - Venzon, D. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 3 SP - 668 EP - 673 SN - 0022-1899 AD - Roilides, E.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931251086. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of granulocyte colony-stimulating factor (G-CSF) and interferon-γ (IFN-γ) on the oxidative burst of neutrophils (PMNL) in response to blastoconidia and pseudohyphae of C. albicans were assessed and compared with those in response to N-FMLP. G-CSF enhanced oxidative burst, as measured by superoxide production, in response to both FMLP and opsonized blastoconidia. The enhancement of oxidative burst in response to FMLP was significantly greater (P=0.004) than that in response to blastoconidia (65 and 39%, respectively). G-CSF also enhanced oxidative burst in response to pseudohyphae. IFN-γ enhanced oxidative burst in response to FMLP and opsonized blastoconidia by 53 and 50%, respectively. Moreover, IFN-γ significantly enhanced oxidative burst in response to opsonized and non-opsonized hyphae by 86 and 65%, respectively. It is concluded that G-CSF and IFN-γ enhance the oxidative burst of PMNL in response to both blastoconidia and pseudohyphae of C. albicans and an immunomodulatory role of the 2 cytokines in the host defences against this fungus is suggested. KW - cytokines KW - immunology KW - neutrophils KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251086&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human herpesvirus 7 (HHV-7) strain JI: independent confirmation of HHV-7. AU - Berneman, Z. N. AU - Gallo, R. C. AU - et al. AU - Ablashi, D. V. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1992/// VL - 166 IS - 3 SP - 690 EP - 691 SN - 0022-1899 AD - Berneman, Z. N.: Laboratory of Tumour Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021204. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - detection KW - strains KW - human herpesvirus 7 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - JI KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021204&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A zinc finger protein from Candida albicans is involved in sucrose utilization. AU - Kelly, R. AU - Kwon-Chung, K. J. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1992/// VL - 174 IS - 1 SP - 222 EP - 232 SN - 0021-9193 AD - Kelly, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921210980. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Registry Number: 9001-42-7. Subject Subsets: Medical & Veterinary Mycology N2 - A sucrose-inducible α-glucosidase activity that hydrolyzes sucrose in C. albicans was demonstrated previously. The enzyme is assayable in whole cells and was inhibited by both sucrose and maltose. A C. albicans gene (CASUC1) that affects sucrose utilization and α-glucosidase activity was cloned by expression in a Saccharomyces cerevisiae suc2 mutant (2102) devoid of invertase genes. CASUC1 enabled the S. cerevisiae mutant to utilize both sucrose and maltose. DNA sequence analysis revealed that CASUC1 encodes a putative zinc finger-containing protein with 28% identity to a maltose-regulatory gene (MAL63) of S. cerevisiae. The gene products of CASUC1 and MAL63 are approximately the same size (501 and 470 amino acids, respectively), and each contains a single zinc finger located at the N terminus. The zinc fingers of CASUC1 and MAL63 comprise 6 conserved cysteines (C6 zinc finger) and are of the general form Cys-Xaa2-Cys-Xaa6-Cys-Xaavariable-Cys-Xaa2-Cys-Xaa6-Cys (where Xaanindicates a stretch of the indicated number of any amino acids). Both contain 5 amino acids in the variable region. CASUC1 also complemented the maltose utilization defect of an S. cerevisiae mutant (TCY-137) containing a defined mutation in a maltose-regulatory gene. The sucrose utilization defect of type II C. stellatoidea, a sucrase-negative mutant of C. albicans, was corrected by CASUC1. Determinations of α-glucosidase activity in whole cells revealed that activity was restored in transformants cultivated on either sucrose or maltose. KW - alpha-glucosidase KW - enzymes KW - genes KW - genetics KW - physiology KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - alpha-D-glucosidase KW - fungus KW - Hyphomycetes KW - maltase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921210980&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogenetic analysis of the genus Borrelia: a comparison of North American and European isolates of Borrelia burgdorferi. AU - Marconi, R. T. AU - Garon, C. F. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1992/// VL - 174 IS - 1 SP - 241 EP - 244 SN - 0021-9193 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515924. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - The 16S rRNA molecules from 4 species of Borrelia and from 6 isolates of B. burgdorferi were sequenced via the reverse transcriptase primer extension method. The sequences were aligned and evolutionary relationships were determined, including the calculation of evolutionary distances and the construction of a phylogenetic tree. These analyses demonstrate significant divergence among B. burgdorferi isolates, with the European isolates G1 and G2 (from man in Germany) residing most distant from the main cluster. Signature nucleotides which distinguish B. burgdorferi from all other members of this genus and which distinguish the European isolates G1 and G2 from the North American isolates B31, Sh-2-82 (both from Ixodes dammini [I. scapularis] in New York) and 1352 (from Amblyomma americanum in Texas) were identified. Finally, Southern blot analyses were performed to compare the restriction patterns of the genes coding for rRNA and to relate the data to the grouping scheme of D. Postic et al. (1990) [see Research in Microbiology, 141: 465-475]. KW - DNA KW - molecular genetics KW - Nucleotide sequences KW - phylogeny KW - Ribosomal RNA KW - taxonomy KW - Europe KW - France KW - Germany KW - New York KW - North America KW - Texas KW - USA KW - Borrelia anserina KW - Borrelia burgdorferi KW - Borrelia coriaceae KW - Borrelia hermsii KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Western Europe KW - Europe KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - North America KW - America KW - Great Plains States of USA KW - Gulf States of USA KW - Southern Plains States of USA KW - West South Central States of USA KW - Southern States of USA KW - Southwestern States of USA KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - rRNA KW - systematics KW - United States of America KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515924&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization. AU - Geber, A. AU - Williamson, P. R. AU - Rex, J. H. AU - Sweeney, E. C. AU - Bennett, J. E. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1992/// VL - 174 IS - 21 SP - 6992 EP - 6996 SN - 0021-9193 AD - Geber, A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19921213302. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 57-50-1. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology; Sugar Industry N2 - In order to isolate the structural gene involved in sucrose utilization, a sucrose-induced C. albicans cDNA library was screened for clones expressing α-glucosidase activity. The C. albicans maltase structural gene (CAMAL2) was isolated. No other clones expressing α-glucosidase activity were detected. A genomic CAMAL2 clone was obtained by screening a size-selected genomic library with the cDNA clone. DNA sequence analysis revealed that CAMAL2 encodes a 570-amino-acid protein which shares 50% identity with the maltase structural gene (MAL62) of Saccharomyces carlsbergensis. The substrate specificity of the recombinant protein purified from Escherichia coli identified the enzyme as a maltase. Northern (RNA) analysis revealed that transcription of CAMAL2 is induced by maltose and sucrose and repressed by glucose. It is suggested that assimilation of sucrose in C. albicans relies on an inducible maltase enzyme. It is concluded that the family of genes controlling sucrose utilization in C. albicans shares similarities with the MAL gene family of S. cerevisiae and provides a model system for studying gene regulation in this pathogenic yeast. KW - genes KW - genetics KW - Sucrose KW - uptake mechanisms KW - yeasts KW - Candida albicans KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungus KW - Hyphomycetes KW - saccharose KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Sugar and Sugar Products (QQ020) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921213302&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Developmentally regulated infectivity of malaria sporozoites for mosquito salivary glands and the vertebrate host. AU - Touray, M. G. AU - Warburg, A. AU - Laughinghouse, A. AU - Krettli, A. U. AU - Miller, L. H. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1992/// VL - 175 IS - 6 SP - 1607 EP - 1612 SN - 0022-1007 AD - Touray, M. G.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920881365. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases N2 - An in vivo assay was developed for mosquito salivary gland invasion by preparing Plasmodium gallinaceum sporozoites from infected Aedes aegypti mosquitoes under physiological conditions and inoculating them into uninfected female A. aegypti. Sporozoites from mature oocysts were isolated from mosquito abdomens 10 or 11 days after an infective blood meal. Salivary gland sporozoites were isolated 13 or 14 days after an infective blood meal. Purified oocyst sporozoites that were inoculated into uninfected female mosquitoes invaded their salivary glands. Using the same assay system, sporozoites derived from salivary glands did not reinvade the salivary glands after inoculation. Conversely, as few as 10 to 50 salivary gland sporozoites induced infection in chickens, while only 2 of 10 chickens inoculated with 5000 oocyst sporozoites were infected. Both sporozoite populations were found to express a circumsporozoite protein on the sporozoite surface as determined by immunofluorescence assay and circumsporozoite precipitation test using a circumsporozoite protein-specific monoclonal antibody. It is concluded that molecules other than this circumsporozoite protein may be responsible for the differential invasion of mosquito salivary glands or infection of the vertebrate host. KW - developmental stages KW - disease vectors KW - immunology KW - infection KW - infectivity KW - livestock KW - parasites KW - poultry KW - salivary glands KW - sporozoites KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - fowls KW - Phasianidae KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Gallus gallus KW - Gallus KW - Phasianidae KW - Galliformes KW - birds KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - chickens KW - domesticated birds KW - growth phase KW - mosquitoes KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881365&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interferon γ induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. AU - Biswas, P. AU - Poli, G. AU - et al. AU - Kinter, A. L. ( JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1992/// VL - 176 IS - 3 SP - 739 EP - 750 SN - 0022-1007 AD - Biswas, P.: (G. Poli) Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 10, Room 11B-13, Bethesda, MD 20892, USA. N1 - Accession Number: 19942021076. Publication Type: Journal Article. Language: English. KW - human immunodeficiency viruses KW - Molecular biology KW - Pathogenesis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942021076&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens. AU - Rawlings, D. J. AU - Kaslow, D. C. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1992/// VL - 176 IS - 5 SP - 1483 EP - 1487 SN - 0022-1007 AD - Rawlings, D. J.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930803435. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all 5 congenic mouse strains responded to several transmission-blocking vaccine candidate antigens, when parasites were emulsified in a monophosphoryl lipid A (MPL) and trehalose dimycolate (TDM) adjuvant. The humoral response in those animals immunized with the antigen in a MPL/TDM adjuvant was helper T cell dependent, as evident by boosting of the antibody response after a 2nd immunization. If the immunogen consisted of purified recombinant protein, then the immune response was not MHC class II limited in mice immunized with either complete Freund's adjuvant or TDM/MPL. The potential role of adjuvants in overcoming apparent immune nonresponsiveness and the implications for development of a malaria transmission-blocking vaccine are discussed. KW - Adjuvants KW - Disease models KW - Experimental infections KW - Human diseases KW - immune response KW - immunization KW - Laboratory animals KW - Major histocompatibility complex KW - malaria KW - parasites KW - T lymphocytes KW - vaccines KW - Apicomplexa KW - mice KW - Muridae KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - falciparum malaria KW - histocompatibility complex KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - T cells KW - transmission-blocking vaccine antigens KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930803435&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The major capsular polysaccharide of Cryptococcus neoformans serotype B. AU - Bhattacharjee, A. K. AU - Kwon-Chung, K. J. AU - Glaudemans, C. P. J. JO - Carbohydrate Research JF - Carbohydrate Research Y1 - 1992/// VL - 233 SP - 271 EP - 272 SN - 0008-6215 AD - Bhattacharjee, A. K.: C. P. J. Glaudemans, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200275. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A recent reinvestigation of the major capsular polysaccharide of C. neoformans serotype B using 1H, 13C NMR and methylation analysis [Turner, S. H.; Cherniak, R. Carbohydrate Research (1991) 211, 103-116] confirmed the originally proposed structure [Bhattacharjee, A. K. (et al.) Carbohydrate Research (1980) 82, 103-111] and stated that the original research paper had presented 2 conflicting sets of methylation data. The authors reply that only a single set of data was displayed for linkage of GlcpA residues. KW - biochemistry KW - polysaccharides KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - capsule KW - complex carbohydrates KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200275&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. AU - Pimenta, P. F. P. AU - Turco, S. J. AU - McConville, M. J. AU - Lawyer, P. G. AU - Perkins, P. V. AU - Sacks, D. L. JO - Science (Washington) JF - Science (Washington) Y1 - 1992/// VL - 256 IS - 5065 SP - 1812 EP - 1815 SN - 0036-8075 AD - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930518213. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Adhesion of L. major promastigotes to the midgut epithelial cells of Phlebotomus papatasi was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific development modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes. KW - Development KW - developmental stages KW - Disease vectors KW - Host parasite relationships KW - human diseases KW - infections KW - Midgut KW - parasites KW - Promastigotes KW - Diptera KW - Leishmania major KW - Phlebotominae KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Trypanosomatidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - growth phase KW - Lipophosphoglycan KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The challenge of malaria. AU - Miller, L. H. JO - Science (Washington) JF - Science (Washington) Y1 - 1992/// VL - 257 IS - 5066 SP - 36 EP - 37 SN - 0036-8075 AD - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804233. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Research priorities for control and eradication of malaria are outlined, including the development of vaccines against both the erythrocytic parasite and sporozoite. The elimination of the vector offers another approach for eradication of Plasmodium falciparum and it is suggested that the introduction of genes which kill the parasite or block parasite development may alter the capacity of mosquitoes to transmit malaria. The identification of biochemical pathways and enzymes unique to the parasite, such as the polymerase involved in haemoglobin digestion, may provide targets for drug design. KW - control KW - Disease control KW - Disease vectors KW - Human diseases KW - Malaria KW - parasites KW - Research KW - Vaccines KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - man KW - Plasmodiidae KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium KW - General account KW - mosquitoes KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Research (AA500) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Aquatic Biology and Ecology (MM300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804233&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of glycogen metabolism in canine myocardium: effects of insulin and epinephrine in vivo. AU - Laughlin, M. R. AU - Taylor, J. F. AU - Chesnick, A. S. AU - Balaban, R. S. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1992/// VL - 262 IS - 6 SP - E875 EP - E883 SN - 0002-9513 AD - Laughlin, M. R.: Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19921453074. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 51-43-4, 9005-79-2, 9004-10-8. Subject Subsets: Human Nutrition N2 - Myocardial glycogen synthesis and glucose, lactate and oxygen extraction were estimated in the hearts of anaesthetized dogs during infusion of insulin and epinephrine. Glycogen synthesis was observed during a venous infusion of insulin and the newly synthesized glycogen was neither broken down nor was more glycogen synthesized during a subsequent epinephrine infusion. During recovery from epinephrine, glycogen synthesis took place at 2.1 times the rate seen in the control period. Glycogen synthesis was not stimulated in the absence of epinephrine by control infusions of saline. Glucose uptake was increased by insulin during the control period, so that the combined extraction of glucose and lactate exceeded the requirement for oxidizable substrate calculated form O2 consumption. The "excess" glucose is presumably available for glycogen synthesis. During recovery from epinephrine, lactate uptake was increased more than 3-fold. Since this additional lactate supplied most of the fuel required for oxidation, the excess glucose available for glycogen synthesis during this period was twice that seen before epinephrine. The data suggest that glycogen synthesis can be activated in the heart without an accompanying increase in glucose uptake by providing an alternative substrate (i.e. lactate) for oxidation. KW - epinephrine KW - Glycogen KW - heart KW - infusion KW - insulin KW - metabolism KW - dogs KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adrenaline KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921453074&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum. AU - Rawlings, D. J. AU - Kaslow, D. C. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 6 SP - 3976 EP - 3982 SN - 0021-9258 AD - Rawlings, D. J.: D.C. Kaslow, Bldg. 4, Room B1-37, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878981. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A 40 000 MW sexual stage radiolabelled surface protein of P. falciparum, Pfs40, was previously identified as a potential target antigen of transmission blocking immunity by an immunogenetic approach. Synthetic oligonucleotide "guessmers", based on micro-sequenced tryptic peptides of Pfs40 purified by 2 dimensional gel electrophoresis, were used to clone the full length cDNA and genomic DNA encoding Pfs40. The deduced amino acid sequence predicted an integral membrane protein containing 5 EF-hand calcium-binding domains. The biological activity of one or more of these domains was confirmed by binding of 45Ca to both native and recombinant Pfs40. Antisera to recombinant Pfs40 immunoprecipitated the native radiolabelled 40 000 MW surface protein. The predicted noncytosolic membrane-associated localization of Pfs40 is unique within the EF-hand calcium-binding protein superfamily. KW - Biochemistry KW - Calcium binding proteins KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - proteins KW - surface antigens KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - 40-kDa KW - biochemical genetics KW - DNA sequences KW - EF-hand calcium binding membrane KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878981&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preparation of a phospholipid-insensitive, Autophosphorylation-activated catalytic fragment of Acanthamoeba myosin I heavy chain kinase. AU - Brzeska, H. AU - Martin, B. AU - Kulesza-Lipka, D. AU - Baines, I. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 7 SP - 4949 EP - 4956 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19920878364. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Protozoology N2 - It was shown that chymotryptic digestion of the Myosin I heavy chain kinase of A. castellanii produces a 54 000 MW fragment which contains 3 to 4 of the ~11 original phosphorylation sites and whose activity is greatly stimulated by autophosphorylation. However, both the rate of autophosphorylation and the kinase activity of the 54 000 MW fragment were independent of phospholipid and comparable to those of intact kinase in the presence of phospholipid. It is implied that the (probably NH2-terminal) region(s) removed by proteolysis is necessary for phospholipid-sensitive inhibition of autophosphorylation of sites residing within the (probably COOH-terminal) 54 000 MW fragment. The 54 000 MW fragment is reported to contain the catalytic site of the kinase as well as 3 to 4 sites whose phosphorylation is necessary for full expression of kinase activity. It was found that the middle region of the kinase molecule contains proline-rich regions that are similar to the COOH-terminal tail of the kinase substrate, Acanthamoeba myosin I. KW - Amoebiasis KW - Biochemistry KW - enzymes KW - Human diseases KW - Kinases KW - MYOSINS KW - parasites KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - amebiasis KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878364&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current perspective on Lyme disease. AU - Kaslow, R. A. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1992/// VL - 267 IS - 10 SP - 1381 EP - 1383 SN - 0098-7484 AD - Kaslow, R. A.: Epidemiology and Biometry Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930882289. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - In this article, a selected case of Borrelia burgdorferi in a 29-year-old woman from Maryland, USA, is presented, before a review of the current state of our knowledge concerning Lyme disease is discussed. The case selected is mild and typical, but fulfills the surveillance case definition. It is suggested that the rising numbers of reported cases may be disturbing indications that the ecology of Lyme disease is more diverse than was at first appreciated. KW - case reports KW - diagnosis KW - epidemiology KW - human diseases KW - Lyme disease KW - reviews KW - symptoms KW - therapy KW - Maryland KW - USA KW - Borrelia burgdorferi KW - man KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - lyme borreliosis KW - therapeutics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930882289&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Guanine nucleotide-binding proteins in the intestinal parasite Giardia lamblia. Isolation of a gene encoding an ~20-kDa ADP-ribosylation factor. AU - Murtagh, J. J., Jr. AU - Mowatt, M. R. AU - Lee, C. M. AU - Lee, F. J. S. AU - Mishima, K. AU - Nash, T. E. AU - Moss, J. AU - Vaughan, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 14 SP - 9654 EP - 9662 SN - 0021-9258 AD - Murtagh, J. J., Jr.: M. Vaughan, Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10/5N307, Bethesda, MD 20892, USA. N1 - Accession Number: 19920879866. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 73-40-5. Subject Subsets: Protozoology N2 - To determine whether genes for guanine nucleotide-binding proteins are present in G. lamblia [G. duodenalis] genomic DNA and cDNA libraries were screened by polymerase chain reaction and by hybridization with mixed oligonucleotide probes complementary to sequences encoding conserved GTP-binding domains. A gene with a high degree of sequence identity with mammalian ADP-ribosylation factors (ARFs), believed to be important in vesicular transport, was identified. The Giardia ARF gene had a 573-base open reading frame encoding 191 amino acids which are 63-70% identical with known mammalian and yeast ARFs. Sequence conservation among ARFs was greatest in putative GTP-binding domains. A single ARF mRNA species of ~ 750 bases was found in 2 different Giardia isolates. Primer extension and RNA sequencing of the Giardia ARF transcript revealed a short (6-base) 5′-untranslated region similar in size to those found in other Giardia transcripts. Giardia extracts contained ARF activity as shown by stimulation of cholera toxin-catalyzed ADP-ribosylation and a Giardia ARF expressed in Escherichia coli as a fusion protein likewise exhibited biochemical activity. Its presence in Giardia is consistent with the view that ARF emerged before the divergence of this protozoan from other eukaryotes (~ 1.5 billion years ago), and that an ARF-like protein may have been the ancestor of several other classes of signal-transducing guanine nucleotide-binding proteins, including the α subunits of the heterotrimeric G proteins. KW - Biochemistry KW - Biotechnology KW - DNA sequencing KW - genes KW - Guanine KW - Human diseases KW - nucleotide sequences KW - Nucleotides KW - parasites KW - proteins KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - DNA sequences KW - GIARDIA LAMBLIA KW - nucleotide sequence analysis KW - nucleotide sequencing KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920879866&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of the actin-activated ATPase and in vitro motility activities of monomeric and filamentous Acanthamoeba myosin II. AU - Ganguly, C. AU - Baines, I. C. AU - Korn, E. D. AU - Sellers, J. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 29 SP - 20900 EP - 20904 SN - 0021-9258 AD - Ganguly, C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808556. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9000-83-3. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activities of Acanthamoeba monomeric dephosphorylated and phosphorylated myosin II were found to be the same as the activity of filamentous dephosphorylated myosin II. The results support the conclusion that phosphorylation regulates filamentous myosin II by affecting filament conformation. Consistent with their equivalent enzymatic activities, monomeric and filamentous dephosphorylated myosin II were equally active in an in vitro motility assay in which myosin adsorbed to a surface drives the movement of F-actin. In contrast to their very different enzymatic activities, however, filamentous and monomeric phosphorylated myosin II had similar activities in the in vitro motility assay; both were much less active than monomeric and filamentous dephosphorylated myosin II. It is thought that the rate-limiting steps in the 2 assays are different and that, while the rate-limiting step for actin-activated Mg2+-ATPase activity is regulated only at the level of the filament, the rate-limiting step for motility can also be regulated at the level of the monomer. KW - adenosinetriphosphatase KW - biochemistry KW - enzymes KW - human diseases KW - motility KW - myosins KW - parasites KW - physiology KW - proteins KW - Acanthamoeba KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - ATPase KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808556&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Limited proteolysis reveals a structural difference in the globular head domains of dephosphorylated and phosphorylated Acanthamoeba myosin II. AU - Ganguly, C. AU - Martin, B. AU - Bubb, M. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 29 SP - 20905 EP - 20908 SN - 0021-9258 AD - Ganguly, C.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808557. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology N2 - Phosphorylation at 3 sites at the tip of the tail of myosin II from Acanthamoeba castellanii inactivates the actin-activated Mg2+-ATPase activity of filamentous myosin and the in vitro motility activity of both monomeric and filamentous myosin. To seek a structural explanation for these effects, susceptibilities of dephosphorylated and phosphorylated myosins II to endoproteinases were examined. Endoproteinase Arg-C cleaved myosin II preferentially at 2 sites in the globular head, Lys-621 and Arg-638, producing an NH2-terminal fragment of about 67 000 MW and a COOH-terminal fragment of about 112 000 MW. Dephosphorylated monomers and filaments were cleaved about 3 times more rapidly than their phosphorylated counterparts principally because of a much greater rate of cleavage at Arg-638; the ratio of cleavage at Arg-638:Lys-621 was about 3 for dephosphorylated myosins and about 0.5 for phosphorylated myosins. The data demonstrate that phosphorylation at the tip of the tail of Acanthamoeba myosin II causes a conformational change in the globular head that contains the catalytic sites; this conformational change is thought to be related to the different catalytic and motile activities of the dephosphorylated and phosphorylated enzymes. KW - motility KW - myosins KW - parasites KW - phosphorylation KW - physiology KW - proteins KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808557&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Acanthamoeba myosin I heavy chain kinase by Ca2+-calmodulin. AU - Brzeska, H. AU - Kulesza-Lipka, D. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 33 SP - 23870 EP - 23875 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804164. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Subject Subsets: Protozoology N2 - It was shown that in Acanthamoeba Ca2+-calmodulin inhibits phospholipid-stimulated autophosphorylation of myosin I heavy chain kinase and also inhibits the catalytic activity of unphosphorylated kinase in the presence of phospholipid. Ca2+-calmodulin does not inhibit kinase activity in the absence of phospholipid. Micromolar Ca2+-calmodulin also inhibits binding of myosin I heavy chain kinase to phospholipid vesicles and purified plasma membranes. Proteolytic removal of a 7000 MW NH2-terminal segment from the 97 000 MW kinase prevents binding of both calmodulin and phospholipid; it is proposed that they bind to the same or overlapping sites. These data provide a mechanism by which Ca2+ could inhibit the actin-activated Mg2+-ATPase activity of the myosin I isozymes in vivo and regulate myosin I-dependent motile activities. KW - Biochemistry KW - enzymes KW - Human diseases KW - Kinases KW - MYOSINS KW - parasites KW - Acanthamoeba KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae. AU - Lee, F. J. S. AU - Moss, J. AU - Vaughan, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 34 SP - 24441 EP - 24445 SN - 0021-9258 AD - Lee, F. J. S.: Laboratory of Cellular Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806703. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology N2 - The 2 yeast ADP-ribosylation factors (ARFs) (~20 000 MW guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro) are >60% identical to mammalian ARFs and are essential for cell viability. Although they are 96% identical in amino acid sequence, the yeast ARF1 gene is constitutively expressed, whereas the ARF2 gene is repressed by glucose. Human ARF5 and ARF6 and a Giardia ARF differ substantially in size and amino acid identity from other mammalian and eukaryotic ARFs but will activate cholera toxin. Expression of human ARF5, ARF6, or Giardia ARF cDNA rescued the lethal yeast ARF double mutant (arf1, arf2). Strains rescued by human ARF5, ARF6 or Giardia ARF grew much more slowly than wild-type yeast or strains rescued with yeast ARF1. It is inferred from the impaired growth of these rescued strains that the homologous ARFs may have specific targeting information that does not interact effectively or efficiently with the yeast protein membrane trafficking system. KW - Genes KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - Giardia KW - Hexamitidae KW - protozoa KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Sarcomastigophora KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Saccharomyces KW - Saccharomycetaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - ADP-ribosylation factors KW - biochemical genetics KW - DNA sequences KW - fungus KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806703&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation. AU - Tang, C. K. AU - Chin, J. AU - Harford, J. B. AU - Klausner, R. D. AU - Rouault, T. A. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1992/// VL - 267 IS - 34 SP - 24466 EP - 24470 SN - 0021-9258 AD - Tang, C. K.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19931465978. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these 2 proteins involved in cellular Fe homeostasis. The activity of IRE-BP is itself regulated by Fe so that when cells are treated with an Fe source, the recombinant human IRE-BP in murine cells and the expressions of the endogenous IRE-BP of human and rabbit cells were examined. In all cases, Fe down-modulated the RNA binding activity of the IRE-BP, but in no instance was this decrease in activity accompanied by a decrease in the concentration of the protein as judged by quantitative Western blots. Moreover, the rate of synthesis of the IRE-BP and its rate of degradation have been found to be unaltered by Fe manipulation of cells in culture. Consistent with IRE-BP regulation occurring post-translationally, the Fe regulation of its activity was found to be unaffected by cycloheximide. The data are discussed in terms of a model of IRE-BP regulation involving the modification of the protein's Fe-sulfur centre. KW - binding proteins KW - cell cultures KW - Gene expression KW - Homeostasis KW - Iron KW - Man KW - Rabbits KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - carrier proteins KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465978&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fatty acid radical formation in rats administered oxidized fatty acids: in vivo spin trapping investigation. AU - Chamulitrat, W. AU - Jordan, S. J. AU - Mason, R. P. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1992/// VL - 299 IS - 2 SP - 361 EP - 367 SN - 0003-9861 AD - Chamulitrat, W.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institute of Health, PO Box 12233, Research Triangle Park, North Crolina 27709, USA. N1 - Accession Number: 19951401111. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Animal Nutrition; Human Nutrition N2 - Evidence is reported for fatty acid-derived free radical metabolite formation in the bile of male Sprague-Dawley rats dosed with spin traps and oxidized polyunsaturated fatty acids. KW - bile KW - fatty acids KW - free radicals KW - in vitro KW - lipid peroxidation KW - polyenoic fatty acids KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gall KW - polyunsaturated fatty acids KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401111&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. AU - Jacobson, M. A. AU - Besch, C. L. AU - Child, C. AU - Hafner, R. AU - Matts, J. P. AU - Muth, K. AU - Wentworth, D. N. AU - Deyton, L. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1992/// VL - 339 IS - 8789 SP - 333 EP - 334 SN - 0140-6736 AD - Jacobson, M. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806939. Publication Type: Journal Article. Corporate Author: Community Programs for Clinical Research on AIDS Language: English. Number of References: 8 ref. Registry Number: 18323-44-9, 58-14-0. Subject Subsets: Protozoology N2 - A double-blind, placebo-controlled trial to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in patients infected with the human immunodeficiency virus (HIV) is reported. Interim analysis showed that clindamycin-treated patients were 4.4 times more likely to experience an adverse effect that necessitated withdrawal of the study drug than those who received placebo. Diarrhoea and rash were reported in 16 (31%) and 11 (21%), respectively, of 52 patients treated with clindamycin (300 mg twice/day) compared with 2 (6%) and none of the 32 placebo-treated patients. KW - acquired immune deficiency syndrome KW - adverse effects KW - antiprotozoal agents KW - clindamycin KW - clinical trials KW - encephalitis KW - human diseases KW - human immunodeficiency viruses KW - opportunistic infections KW - parasites KW - prophylaxis KW - pyrimethamine KW - toxicity KW - California KW - North America KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - AIDS KW - encephalomyelitis KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806939&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Improved diagnosis of Pneumocystis carinii infection by polymerase chain reaction on induced sputum and blood. AU - Lipschik, G. AU - Gill, V. J. AU - Lundgren, J. D. AU - Andrawis, V. A. AU - Nelson, N. A. AU - Nielsen, J. O. AU - Ognibene, F. P. AU - Kovacs, J. A. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1992/// VL - 340 IS - 8813 SP - 203 EP - 206 SN - 0140-6736 AD - Lipschik, G.: Critical Care Medicine Department, Warren G. Magnuson Clinical Centre, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19920881648. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology N2 - The sensitivity and specificity of two polymerase chain reaction (PCR) methods are compared with conventional staining methods for detection of Pneumocystis carinii in induced sputum, bronchoalveolar lavage fluid, and blood. A nested PCR method correctly identified the presence of P. carinii in 17 microbiologically confirmed sputum samples from HIV-positive and other immunocompromised patients. PCR with a single primer pair was 71% sensitive and 94% specific. The sensitivity of conventional staining methods was significantly less than that of nested PCR. In bronchoalveolar lavage fluid, neither PCR method was significantly better than conventional staining methods. The report suggests that nested PCR on induced sputum is more sensitive than conventional staining methods for the diagnosis of P. carinii pneumonia. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - blood KW - diagnosis KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - polymerase chain reaction KW - sputum KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - AIDS KW - fungus KW - human immunodeficiency virus KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881648&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathophysiology of obesity. AU - Ravussin, E. AU - Swinburn, B. A. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1992/// VL - 340 IS - 8816 SP - 404 EP - 408 SN - 0140-6736 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541-A, Pheonix, Arizona 85016, USA. N1 - Accession Number: 19921449243. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - Pathophysiology of obesity is reviewed. Topics covered include genetic versus environmental aetiology, food intake, energy balance and expenditure, risk factors for weight gain, nutrient balance equations and some implications for treatment and prevention. KW - Obesity KW - physiopathology KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - pathophysiology KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921449243&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficacy of atovaquone in treatment of toxoplasmosis in patients with AIDS. AU - Kovacs, J. A. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1992/// VL - 340 IS - 8820 SP - 637 EP - 638 SN - 0140-6736 AD - Kovacs, J. A.: Critical Care Medicine Deopartment, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA. N1 - Accession Number: 19920881621. Publication Type: Journal Article. Corporate Author: NIAID-Clinical Center Intramural AIDS Program Language: English. Number of References: 10 ref. Registry Number: 95233-18-4. Subject Subsets: Protozoology N2 - Atovaquone (formerly 566C80) has been shown to exhibit potent activity against Toxoplasma gondii in vitro and in laboratory animals. Eight patients with AIDS and presumed or biopsy confirmed toxoplasmosis who were intolerant of or who had not responded to standard therapy were treated with oral atovaquone 750 mg 4 times/day. Seven patients showed radiographic improvement; the other remained radiographically stable. Six patients died 6-60 weeks after enrolment with no clinical (6) or necropsy (3) evidence of recurrent toxoplasmosis; 2 patients relapsed at 10 and 32 weeks. One patient required temporary discontinuation of the drug due to a rash. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - adverse effects KW - atovaquone KW - central nervous system KW - drug therapy KW - ELISA KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - radiography KW - North America KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - adverse reactions KW - AIDS KW - chemotherapy KW - CNS KW - enzyme linked immunosorbent assay KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881621&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - How chloroquine works. AU - Wellems, T. E. JO - Nature (London) JF - Nature (London) Y1 - 1992/// VL - 355 IS - 6356 SP - 108 EP - 109 SN - 0028-0836 AD - Wellems, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803842. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 14875-96-8. Subject Subsets: Protozoology N2 - In this article, the work of Slater and Cerami (Nature (1992) 355, 167-169) is discussed. These authors have shown that chloroquine interferes with a haem detoxification enzyme (haem polymerase) that is essential for the survival of malaria parasites in erythrocytes. With chloroquine resistance, it is suggested that Plasmodium falciparum does not concentrate the drug to the high levels found in sensitive parasites, presumably keeping intravacuolar chloroquine levels below those that would inhibit haem polymerase. An efflux mechanism releases chloroquine from resistant parasites 40-50 times faster than from sensitive parasites. It is suggested that in haem polymerization, P. falciparum is demonstrating a vulnerable target that may prove extremely useful in the treatment of chloroquine resistance.<new para>ADDITIONAL ABSTRACT:<new para>The mode of action of chloroquine is briefly discussed with particular reference to the paper by Stater and Cerami (Nature (London), (1992) 355 (6356), 167-169) which reports that chloroquine interferes with a haem detoxification enzyme that is essential to the survival of malaria parasites in red blood cells. KW - antimalarials KW - antiprotozoal agents KW - chloroquine KW - drug resistance KW - enzyme activity KW - haem KW - human diseases KW - in vitro KW - malaria KW - mode of action KW - parasites KW - polymerization KW - Apicomplexa KW - man KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - heme KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803842&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasitizing the cytokine system. AU - Sher, A. AU - Amiri, P.\Locksley, R. M.\Parslow, T. G.\Sadick, M.\Rector, E.\Ritter, D.\McKerrow, J. H. JO - Nature (London) JF - Nature (London) Y1 - 1992/// VL - 356 IS - 6370 SP - 565 EP - 566 SN - 0028-0836 AD - Sher, A.: Laboratory of Parasitic Diseases, NIH National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950806781. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 308079-78-9. Subject Subsets: Helminthology N2 - Following the letter by Amiri et al. (Nature (1992) 356, 604-607), it is suggested that the conventional view that schistosomal granulomas represent a dynamic outcome of different T lymphocyte, lymphokine and inflammatory cell responses must now be challenged. Amiri et al. showed that, in the absence of B and T lymphocytes, a single lymphokine, tumour necrosis factor α (TNFα), is sufficient to trigger egg-granuloma formation. They also suggested that Schistosoma uses host TNFα as a reproductive stimulus. KW - granuloma KW - helminth ova KW - helminths KW - immune response KW - liver KW - lymphocytes KW - parasites KW - reproduction KW - tumour necrosis factor KW - mice KW - Schistosoma KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - cachectin KW - cachexin KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806781&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production of anti-idiotypic antibodies as potential immunoreagents for the serological diagnosis of bovine cysticercosis. AU - Hayunga, E. G. AU - Sumner, M. P. AU - Duncan, J. F., Jr. AU - Chakrabarti, E. K. AU - Webert, D. W. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1992/// VL - 653 SP - 178 EP - 183 SN - 0077-8923 AD - Hayunga, E. G.: Division of Research Grants, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806708. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Helminthology N2 - This study aimed to demonstrate the feasibility of using anti-idiotypic antibodies as alternative immunoreagents for the serological diagnosis of bovine cysticercosis (Taenia saginata). Rabbits and mice were inoculated with a 12 000 MW fraction of Taenia hydatigena cyst fluid (ThFAS) to produce either polyclonal or monoclonal antibodies (idiotypes), respectively. IgG idiotypes were purified by preparative protein A column, then inoculated into other rabbits to produce anti-idiotypes. The presence of anti-idiotypes in hyperimmune serum was demonstrated by competitive inhibition ELISA. The anti-idiotypes were then purified and used as coating antigen in a plate ELISA; results were compared to those using ThFAS as coating antigen. The absorbance values for infection serum obtained using the anti-idiotype were less than those using the native antigen, but were nevertheless significantly different from the control. It is concluded that anti-idiotypes can be used as synthetic antigens for diagnostic purposes. KW - Antibodies KW - antigens KW - ELISA KW - helminths KW - idiotypes KW - immunodiagnosis KW - Livestock KW - metacestodes KW - parasites KW - Artiodactyla KW - Bovidae KW - cattle KW - Cestoda KW - Ruminants KW - Taenia hydatigena KW - Taenia saginata KW - Taeniidae KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ruminants KW - Artiodactyla KW - Bos KW - Bovidae KW - Platyhelminthes KW - invertebrates KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - antigenicity KW - enzyme linked immunosorbent assay KW - immunogens KW - parasitic worms KW - serological diagnosis KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid bioavailability in humans: ascorbic acid in plasma, serum, and urine. AU - Wang, Y. H. AU - Dhariwal, K. R. AU - Levine, M. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1992/// VL - 669 SP - 383 EP - 386 SN - 0077-8923 AD - Wang, Y. H.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19931459880. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Registry Number: 50-81-7, 490-83-5. Subject Subsets: Human Nutrition KW - Ascorbic acid KW - Binding proteins KW - blood KW - Dehydroascorbic acid KW - stability KW - urine KW - USA KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - carrier proteins KW - New views on the function and health effects of vitamins KW - United States of America KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459880&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Eicosanoids and health. AU - Lands, W. E. M. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1992/// VL - 676 SP - 46 EP - 59 SN - 0077-8923 AD - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, Parklawn Building, Rm 16C-06, 5600 Fishers Lane, Rockville, Maryland 20857, USA. N1 - Accession Number: 19931466969. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition N2 - The role of eicosanoids as cellular mediators in health and cardiovascular diseases is reviewed including a discussion on the supply of n-6 and n-3 fatty acid precursors, dietary imbalances of these fatty acids and assessment of their nutritional status. KW - cardiovascular diseases KW - eicosanoids KW - health KW - polyenoic fatty acids KW - reviews KW - Japan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - polyunsaturated fatty acids KW - Third International Conference on Nutrition in Cardio-Cerebrovascular Diseases KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466969&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet and cancer prevention: a National Cancer Institute priority. AU - Greenwald, P. AU - Clifford, C. JO - Vitamins and cancer prevention JF - Vitamins and cancer prevention Y1 - 1992/// IS - 3 SP - 1 EP - 22 CY - Baton Rouge; USA PB - Louisiana State University Press SN - 0807117897 AD - Greenwald, P.: Division of Cancer Prevention and Control, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402899. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - The main efforts of the National Cancer Institute (USA) since the 1970's in investigating the role of diet in cancer prevention are discussed. KW - carcinoma KW - diet KW - government organizations KW - neoplasms KW - prevention KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Vitamins and cancer prevention KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402899&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oral isotretinoin is effective in the prevention of skin cancer in patients with xeroderma pigmentosum. AU - DiGiovanna, J. J. AU - Kraemer, K. H. AU - Peck, G. L. AU - Abangan, D. L. JO - Vitamins and cancer prevention JF - Vitamins and cancer prevention Y1 - 1992/// IS - 3 SP - 188 EP - 195 SN - 0807117897 AD - DiGiovanna, J. J.: Dermatology Branch, National Cancer Institute, National Institute of Health Building 10, Room 12N238, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402910. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 10 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - 5 patients with xeroderma pigmentosum were cleared of existing cancers and treated daily for 2 years with isotretinoin (a derivative of vitamin A) 2.0 mg/kg. Patients had a significant decrease in the number of new basal- and squamous-cell carcinomas. After treatment was discontinued however, the incidences of new skin cancers returned to pretreatment levels. In another study, it was investigated whether chemoprevention could be obtained with less toxicity. 7 patients were treated daily with isotretinoin 0.5 mg/kg. In most of these, the frequency of skin cancers decreased compared with periods of no treatment and toxicities were less frequent compared with the high-dose treatment. It is concluded that oral isotretinoin is effective in preventing skin cancer in patients with xeroderma pigmentosum with the lowest effective, least toxic dosage varying among patients. KW - carcinoma KW - derivatives KW - neoplasms KW - prevention KW - retinol KW - skin KW - skin diseases KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - dermatoses KW - dermis KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Vitamins and cancer prevention KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402910&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does beta-carotene explain why reduced cancer risk is associated with vegetable and fruit intake? New research directions. AU - Ziegler, R. G. AU - Ursin, G. AU - Craft, N. E. AU - Subar, A. F. AU - Graubard, B. I. AU - Patterson, B. H. JO - Vitamins and cancer prevention JF - Vitamins and cancer prevention Y1 - 1992/// IS - 3 SP - 352 EP - 371 CY - Baton Rouge; USA PB - Louisiana State University Press SN - 0807117897 AD - Ziegler, R. G.: Epidemiology and Biostatisitcs Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, No. 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402922. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - This article reviews the relation between reduced cancer risk and β-carotene (provided by fruit and vegetables) intake. 3 approaches are used: data from the 1982-84 Epidemiologic Followup Study of the first National Health and Nutrition Examination Survey and the 1987 National Health Interview Study (USA) are used to examine which food groups correlate with fruit and vegetable intake; a liquid chromatographic method for the resolution of the common carotenoids in blood is presented; and a population-based case-control study of lung cancer among white men in New Jersey is discussed to assess whether intakes of individual carotenoids can produce strong inverse associations. KW - beta-carotene KW - carcinoma KW - diet studies KW - intake KW - prevention KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Vitamins and cancer prevention KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402922&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. AU - Sher, A. AU - Gazzinelli, R. T. AU - Oswald, I. P. AU - Clerici, M. AU - Kullberg, M. AU - Pearce, E. J. AU - Berzofsky, J. A. AU - Mosmann, T. R. AU - James, S. L. AU - Morse, H. C., III AU - Shearer, G. M. JO - Immunological Reviews JF - Immunological Reviews Y1 - 1992/// IS - 127 SP - 183 EP - 204 SN - 0105-2896 AD - Sher, A.: Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804554. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Protozoology; Helminthology N2 - Evidence for the Th2 immunoregulatory pathway and its possible functions in the immunosuppression accompanying parasitic (Leishmania, Trypanosoma cruzi, Toxoplasma gondii, Schistosoma mansoni) and retroviral infections are discussed. KW - Cytokines KW - helminths KW - immune response KW - Immunology KW - Parasites KW - reviews KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current status of HIV therapy: I. Antiretroviral agents. AU - Hoth, D. F., Jr. AU - Meyers, M. W. AU - Stein, D. S. AU - Feinberg, J. JO - Hospital Practice JF - Hospital Practice Y1 - 1992/// IS - Sept. 15 SP - 145 EP - 156 SN - 0018-5809 AD - Hoth, D. F., Jr.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19932022066. Publication Type: Journal Article. Language: English. N2 - Part II, concentrating on opportunistic diseases, follows in the same issue (J. Feinberg and D.F. Hoth Jr, pp. 161-174). KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - drug therapy KW - HIV infections KW - Opportunistic infections KW - AIDS KW - chemotherapy KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022066&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Developing drugs for the deep mycoses: a short history. AU - Bennett, J. E. A2 - Bennett, J. E. A2 - Hay, R. J. A2 - Peterson, P. K. T2 - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JO - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JF - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. Y1 - 1992/// SP - 3 EP - 12 CY - Edinburgh; UK PB - Churchill Livingstone SN - 0443046840 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19921212122. Publication Type: Conference paper. Language: English. Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The history of the development of various antifungal agents, including amphotericin B, flucytosine and azoles, is discussed. KW - Antifungal agents KW - history KW - fungistats KW - New strategies in fungal disease KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212122&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Dietary assessment methods for macronutrients. AU - Hartman, A. M. AU - Block, G. A2 - Micozzi, M. S. A2 - Moon, T. E. T2 - Macronutrients: investigating their role in cancer. JO - Macronutrients: investigating their role in cancer. JF - Macronutrients: investigating their role in cancer. Y1 - 1992/// SP - 87 EP - 124 CY - New York; USA PB - Marcel Dekker Inc. SN - 0824785932 AD - Hartman, A. M.: Division of Cancer Prevention and Control, National Cancer Institute , National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931460935. Publication Type: Miscellaneous. Language: English. Number of References: 125 ref. Subject Subsets: Human Nutrition N2 - Dietary assessment methods, their validity and the use and limitations of the type of data they produce are reviewed. KW - Diet study techniques KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Rapid identification of small supercoiled plasmids in cloned populations of Borrelia burgdorferi. AU - Schwan, T. G. AU - Schrumpf, M. E. AU - Karstens, R. H. A2 - Munderloh, U.G. A2 - Kurtti, T.J. T2 - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA. JO - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA. JF - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology and Minnesota Extension Service, Saint Paul, Minnesota, USA. Y1 - 1992/// SP - 89 EP - 94 CY - St Paul, Minnesota; USA PB - University of Minnesota AD - Schwan, T. G.: Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950506531. Publication Type: Conference paper. Language: English. Number of References: 8 ref. KW - Lyme disease KW - molecular genetics KW - pathogens KW - plasmids KW - tickborne diseases KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Vector/spirochete relationships of arthropod-borne borrelioses. AU - Burgdorfer, W. A2 - Munderloh, U.G. A2 - Kurtti, T.J. T2 - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. JO - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. JF - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. Y1 - 1992/// SP - 111 EP - 120 CY - St Paul, Minnesota; USA PB - University of Minnesota AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19950506534. Publication Type: Conference paper. Language: English. Number of References: 35 ref. N2 - This paper includes a general table of arthropod-borne borrelioses, their vectors, reservoirs, distributions and disease names. KW - disease vectors KW - host parasite relationships KW - pathogens KW - reviews KW - tickborne diseases KW - Argasidae KW - Borrelia burgdorferi KW - Borrelia recurrentis KW - Ixodes persulcatus KW - Ixodes ricinus KW - Ixodidae KW - Ornithodoros KW - Pediculus humanus KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Argasidae KW - Pediculus KW - Pediculidae KW - Anoplura KW - Phthiraptera KW - insects KW - Hexapoda KW - bacterium KW - body louse KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Body fat distribution and breast cancer preliminary results from a case-control study in women from Southern Italy. AU - Borrelli, R. AU - De Filippo, E. AU - Scalfi, L. AU - Buglione, G. AU - Contaldo, F. AU - Marone, A. AU - Parisi, V. AU - Cremona, F. AU - Scognamiglio, F. AU - Palaia, R. AU - Ruffolo, F. AU - Salvatore, M. A2 - Ailhaud, G. A2 - Guy-Grand, B. A2 - Lafontan, M. A2 - Ricquier, D. T2 - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity. JO - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity. JF - Obesity in Europe 91. Proceedings of the 3rd European Congress on Obesity. Y1 - 1992/// SP - 125 EP - 128 CY - London; UK PB - John Libbey & Company Ltd SN - 0861962737 AD - Borrelli, R.: Clinical Nutrition, 2nd Medical School, University of Naples and National Cancer Institute (NCI), Naples, Italy. N1 - Accession Number: 19921445280. Publication Type: Conference paper. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - 115 women admitted to the National Cancer Institute, Naples, submitted to breast biopsy and anthropometry, and completed a dietary and life-style questionnaire. 82 were identified as having breast cancer and 33 benign breast disease (mastitis, fibrocystic disease, etc.). Body measurements included height; weight; skinfold thickness (biceps, triceps, suprailiac and subscapular); chest, waist, hip and arm circumference; body mass index (kg/m²); waist/hip ratio; subscapular/triceps skinfold thickness ratio. Women with breast cancer were bigger (as shown by greater circumferences) and had a more pronounced abdominal distribution of fat (higher waist/hip ratio) than women with benign breast disease. Skinfold thickness was greater in cancer patients but the difference only reached significance (P<0.05) in the subscapular skinfold. It is concluded that body fat distribution could represent a risk factor not only for cardiovascular diseases but also for some female carcinomas, such as breast cancer. KW - body fat KW - Carcinoma KW - distribution KW - mammary glands KW - France KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Western Europe KW - Europe KW - European Congress on Obesity KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445280&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Recent advances in the molecular genetics of Cryptococcus neoformans. AU - Kwon-Chung, K. J. AU - Edman, J. C. A2 - Bennett, J. E. A2 - Hay, R. J. A2 - Peterson, P. K. T2 - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JO - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JF - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. Y1 - 1992/// SP - 195 EP - 207 CY - Edinburgh; UK PB - Churchill Livingstone SN - 0443046840 AD - Kwon-Chung, K. J.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19921212132. Publication Type: Conference paper. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Molecular biological studies with the emphasis on gene cloning, karyotyping, and the relationship between DNA-mediated transformation and virulence of C. neoformans are discussed. KW - genetics KW - molecular genetics KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - biochemical genetics KW - fungus KW - New strategies in fungal disease KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212132&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Energy intake and cancer. AU - Albanes, D. A2 - Micozzi, M. S. A2 - Moon, T. E. T2 - Macronutrients: investigating their role in cancer. JO - Macronutrients: investigating their role in cancer. JF - Macronutrients: investigating their role in cancer. Y1 - 1992/// SP - 205 EP - 229 CY - New York; USA PB - Marcel Dekker Inc. SN - 0824785932 AD - Albanes, D.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931460944. Publication Type: Miscellaneous. Language: English. Number of References: 125 ref. Subject Subsets: Human Nutrition N2 - The relationship between energy intake and cancer is reviewed. Results from early studies on animals and later epidemiologic studies are included. KW - Carcinoma KW - energy intake KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Models of Human Nutrition (VV140) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460944&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immunodiagnosis of invasive candidiasis in patients with neoplastic diseases. AU - Walsh, T. J. AU - Lee, J. W. AU - Pizzo, P. A. A2 - Bennett, J. E. A2 - Hay, R. J. A2 - Peterson, P. K. T2 - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JO - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. JF - New strategies in fungal disease. Proceedings of an international symposium, Brocket Hall, Hertfordshire, UK, 21-24 September 1991. Y1 - 1992/// SP - 227 EP - 242 CY - Edinburgh; UK PB - Churchill Livingstone SN - 0443046840 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19921212134. Publication Type: Conference paper. Language: English. Number of References: 61 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Markers, including mannans, D-arabinitol, Candida enolase and Candida heat shock protein, are discussed as they pertain to invasive candidosis in patients with neoplastic diseases, paying particular attention to immunodiagnostic techniques. KW - diagnosis KW - immunological techniques KW - infections KW - neoplasms KW - predisposition KW - Candida KW - Man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - cancers KW - fungus KW - Hyphomycetes KW - New strategies in fungal disease KW - serological techniques KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212134&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HIV interactions with some endemic diseases in Africa. AU - Williams, A. O. A2 - Williams, A. O. T2 - AIDS: an African perspective. JO - AIDS: an African perspective. JF - AIDS: an African perspective. Y1 - 1992/// SP - 233 EP - 251 CY - Boca Raton; USA PB - CRC Press Inc. SN - 084936437X AD - Williams, A. O.: National Institutes of Health, Fogarty International Center for Advanced Study, Bethesda, MD, USA. N1 - Accession Number: 19930804462. Publication Type: Miscellaneous. Language: English. Number of References: 145 ref. Subject Subsets: Protozoology; Helminthology N2 - Some endemic infectious diseases and their interactions with HIV in sub-Saharan Africa, including malaria, tuberculosis and other myco-bacterial infections, leprosy, leishmaniasis, African trypanosomiasis, helminth infections, enteropathogens, hepatitis B, C and D viruses, and Epstein-Barr virus infections are discussed. It is highlighted that tuberculosis is frequently reactivated in HIV-infected individuals. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Helminths KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Interactions KW - Leishmaniasis KW - Malaria KW - Opportunistic infections KW - parasites KW - reviews KW - Trypanosomiasis KW - Africa KW - Apicomplexa KW - Leishmania KW - man KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Sarcomastigophora KW - Trypanosoma KW - Trypanosomatidae KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - AIDS KW - human immunodeficiency virus KW - leishmaniosis KW - parasitic worms KW - trypanosomosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804462&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Transovarial transmission: an effective ecological means for the survival of tick-borne spotted fever group rickettsiae. AU - Burgdorfer, W. A2 - Munderloh, U.G. A2 - Kurtti, T.J. T2 - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. JO - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. JF - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA. Y1 - 1992/// SP - 265 EP - 272 CY - St Paul, Minnesota; USA PB - University of Minnesota AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19950506554. Publication Type: Conference paper. Language: English. Number of References: 13 ref. KW - disease vectors KW - host parasite relationships KW - infections KW - pathogens KW - Rocky Mountain spotted fever KW - tickborne diseases KW - transovarial transmission KW - Dermacentor andersoni KW - Dermacentor variabilis KW - Rickettsia montanensis KW - Rickettsia rhipicephali KW - Rickettsia rickettsii KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - parasite host relationships KW - Rickettsia montana KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Dietary fiber. AU - Lanza, E. AU - Shankar, S. AU - Trock, B. A2 - Micozzi, M. S. A2 - Moon, T. E. T2 - Macronutrients: investigating their role in cancer. JO - Macronutrients: investigating their role in cancer. JF - Macronutrients: investigating their role in cancer. Y1 - 1992/// SP - 293 EP - 319 CY - New York; USA PB - Marcel Dekker Inc. SN - 0824785932 AD - Lanza, E.: National Cancer Institute, National Institute of Health, Bethedsa, Maryland, USA. N1 - Accession Number: 19931460948. Publication Type: Miscellaneous. Language: English. Number of References: 98 ref. Subject Subsets: Human Nutrition N2 - Evidence for the role of a fibre-rich diet in the prevention of certain types of cancers, especially colon and breast cancer, is reviewed. KW - Carcinoma KW - Diet KW - fibre KW - Neoplasms KW - prevention KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - fiber KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460948&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Survey of some Indian medicinal plants for receptor specific protein. AU - Bhupati Bhattacharya AU - Chakraborti, S. K. A2 - Raychaudhuri, S. P. T2 - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India. JO - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India. JF - Recent advances in medicinal, aromatic and spice crops (Volume 2). International conference held on 28-31 January 1989, at New Delhi, India. Y1 - 1992/// SP - 365 EP - 369 CY - New Delhi; India PB - Today & Tomorrow's Printers & Publishers SN - 8170194121\1555282660 AD - Bhupati Bhattacharya: Department of Chemotherapy, Chittaranjan National Cancer Institute, 37 S. P. Mookerjee Road, Calcutta-700 026, India. N1 - Accession Number: 19950312662. Publication Type: Conference paper. Language: English. Number of References: 8 ref. Subject Subsets: Horticultural Science N2 - Plant lectins (receptor specific proteins, RSP) were extracted from the seeds of 18 medicinal plants. Agglutination tests were carried out on tumour cells (Ehrlich ascites cells from mice; EAC), and antitumour activity was assessed in vitro and in vivo. Lectins extracted from Artocarpus integrifolia [A. integer] showed the highest level of agglutination (90%) with only 3 other species having any activity at all in this test (Citrullus vulgaris [C. lanatus], Syzygium cumini and Liquidambar chinensis [Altingia chinensis]). Populus alba showed an inhibitory effect on EAC tumour cells in vitro at a dose level of 2.5 mg/kg. Four species (Poinciana pulcherrima [Caesalpinia pulcherrima], Nyctanthes arbor-tristis, Mirabilis jalapa and Populus alba) showed in vivo antitumour activity (against EAC or S-180 in mice) as evidenced by T/C (treatment/control) mean survival time values >125%. KW - antineoplastic properties KW - cytotoxicity KW - jackfruits KW - lectins KW - medicinal plants KW - pharmacology KW - seeds KW - surveys KW - watermelons KW - India KW - Artocarpus KW - Artocarpus heterophyllus KW - Artocarpus integer KW - Caesalpinia pulcherrima KW - Citrullus lanatus KW - mice KW - Mirabilis jalapa KW - Nyctanthes arbor-tristis KW - Populus alba KW - Syzygium cumini KW - Moraceae KW - Urticales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Artocarpus KW - Caesalpinia KW - Caesalpinioideae KW - Fabaceae KW - Fabales KW - Citrullus KW - Cucurbitaceae KW - Violales KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Mirabilis KW - Nyctaginaceae KW - Caryophyllales KW - Nyctanthes KW - Verbenaceae KW - Lamiales KW - Populus KW - Salicaceae KW - Salicales KW - Syzygium KW - Myrtaceae KW - Myrtales KW - Altingia KW - Hamamelidaceae KW - Hamamelidales KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - Altingia chinensis KW - anti-neoplastic properties KW - drug plants KW - medicinal herbs KW - officinal plants KW - Recent advances in medicinal, aromatic and spice crops KW - white poplar KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950312662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fruit and vegetable consumption: national survey data. AU - Patterson, B. H. AU - Block, G. A2 - Bendich, A. A2 - Butterworth, C. E., Jr. T2 - Micronutrients in health and in disease prevention. JO - Micronutrients in health and in disease prevention. JF - Micronutrients in health and in disease prevention. Y1 - 1992/// SP - 409 EP - 436 CY - New York; USA PB - Marcel Dekker SN - 0824785398 AD - Patterson, B. H.: Division of Cancer Prevention and Control, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931462368. Publication Type: Miscellaneous. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - US national survey data are reviewed in an effort to characterize the actual diet of adult Americans with respect to fruit and vegetables. The surveys used are the Second National Health and Nutrition Examination Survey; the Nationwide Food Consumption Survey; the Continuing Survey of Food Intakes by Individuals; and the Cancer Supplement of the National Health Interview. KW - consumption KW - diet studies KW - Foods KW - Fruit KW - reviews KW - Vegetables KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - vegetable crops KW - Food Science and Food Products (Human) (QQ000) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462368&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - T-cell regulation of immediate hypersensitivity: lessons from helminth parasites and allergic diseases. AU - Nutman, T. B. A2 - Moqbel, R. T2 - Allergy and immunity to helminths: common mechanisms or divergent pathways. Y1 - 1992/// CY - London; UK PB - Taylor & Francis Ltd. SN - 0748400222 AD - Nutman, T. B.: Laboratory of Parasitic Diseases, Building 4, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930807975. Publication Type: Book chapter. Language: English. Number of References: 104 ref. Subject Subsets: Helminthology N2 - The role of T-cells and their products in the regulation of immediate hypersensitivity responses is discussed with regard to: T-cell clones (virally-transformed T-cell clones, mitogen-driven T-cell clones, allergen-specific T-cell clones, parasite-specific T-cell clones); cytokine expression in parasitic infections and allergic diseases; the role of antigen structure; antigen presentation. KW - helminths KW - Human diseases KW - hypersensitivity KW - Immediate hypersensitivity KW - immune response KW - immunity KW - parasites KW - T lymphocytes KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - allergic responses KW - hypersensitiveness KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807975&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes). AU - Robbins, R. G. AU - Keirans, J. E. T2 - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes). Y1 - 1992/// CY - Lanham, Maryland; USA PB - Entomological Society of America SN - 0938522388 AD - Robbins, R. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, c/o Department of Entomology, Museum Support Center, Smithsonian Institution, Washington, DC 20560, USA. N1 - Accession Number: 19950503710. Publication Type: Book. Language: English. Number of References: 16 pp. of ref. Subject Subsets: Medical & Veterinary Entomology N2 - This monograph endeavours to: (1) summarize and evaluate previous observations on the morphology, hosts and distribution of each species in the Ixodes tick subgenus Ixodiopsis; (2) present the results of the authors' original research on the taxonomy and bionomics of this close-knit assemblage; and (3) analyse the evolutionary and zoogeographic history of this group in the light of current phylogenetic methodology. This Holarctic subgenus, often referred to as the "Ixodes angustus group", contains 7 species: I. angustus, I. eastoni, I. ochotonae, I. pomerantzevi, I. soricis, I. stromi and I. woodi. This book contains a diagnosis of Ixodiopsis, keys (to males, females, nymphs and larvae), synopses of species, material examined and sections on phylogenetics, ecology and zoogeography. There are 2 appendixes: a glossary, and a classified host-parasite list. A comprehensive index to the tick species completes the book. KW - biosystematics KW - ecology KW - ectoparasites KW - geographical distribution KW - Holarctic Region KW - hosts KW - keys KW - phylogeny KW - redescriptions KW - taxonomy KW - wild animals KW - zoogeography KW - Asia KW - Europe KW - North America KW - Acari KW - Arachnida KW - insectivores KW - Ixodes KW - Lagomorpha KW - mammals KW - rodents KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - mammals KW - vertebrates KW - Chordata KW - Ixodidae KW - Metastigmata KW - Acari KW - Ixodes KW - America KW - animal geography KW - Ixodes angustus KW - Ixodes eastoni KW - Ixodes ochotonae KW - Ixodes pomerantzevi KW - Ixodes soricis KW - Ixodes stromi KW - Ixodes woodi KW - Ixodiopsis KW - revision KW - systematics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) KW - Biological Resources (Animal) (PP710) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prosthetic joint infection with Actinomyces viscosus. AU - Cohen, O. J. AU - Keiser, J. AU - Pollner, J. AU - Parenti, D. M. JO - Infectious Diseases in Clinical Practice JF - Infectious Diseases in Clinical Practice Y1 - 1993/// VL - 2 IS - 5 SP - 349 EP - 351 SN - 1056-9103 AD - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200710. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - A case is reported in a 61-yr-old man from the USA who presented with a 3-wk history of left hip pain with decreased range of motion and fever, 16 yr after a total left hip replacement. Radiographs of the left hip revealed diffuse destruction of the left hip joint with large amounts of heterotopic bone. There was marked deformity of the proximal femur with evidence of periosteal reaction along its lateral margin. The infected left hip prosthesis was removed and a pathological examination of the native bone showed chronic suppurative arthritis and osteomyelitis. A Gram stain of pus obtained from the left hip showed rare, pleomorphic, Gram positive organisms, identified as A. viscosus. Symptoms resolved after intravenous penicillin therapy with no recurrence in 6 months of follow-up. A search for the primary focus of A. viscosus infection was inconclusive. 13 previously reported cases of extraoral A. viscosus infection are also discussed. KW - actinomycosis KW - arthritis KW - case reports KW - human diseases KW - joints (animal) KW - predisposition KW - prostheses KW - North America KW - USA KW - Washington KW - Actinomyces viscosus KW - man KW - Actinomyces KW - Actinomycetaceae KW - Actinomycineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - bacterium KW - joints KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A comparison of risk factors for human immunodeficiency virus and hepatitis B virus infections in homosexual men. AU - Koziol, D. E. AU - Saah, A. J. AU - Odaka, N. AU - Muñoz, A. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1993/// VL - 3 IS - 4 SP - 434 EP - 441 SN - 1047-2797 AD - Koziol, D. E.: Hospital Epidemiology Service, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005089. Publication Type: Journal Article. Language: English. Number of References: 43 ref. N2 - The authors analysed cross-sectional data from 1062 homosexual men recruited in Baltimore, USA, during 1984, to directly compare risk factors for human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Using polychotomous logistic regression, risk factor odds ratios (ORs) and 95% confidence intervals were determined for men with HIV alone, men with HBV alone, and men with both HIV and HBV, compared to seronegative men, and paired comparisons among these subgroups. Factors associated with the serological prevalence of HIV alone and HBV alone (with respective ORs) included anal receptive intercourse (HIV OR = 1.23; HBV OR = 1.12), history of gonorrhea (HIV OR = 4.58; HBV OR = 2.52) and rectal douching (HIV OR = 1.41; HBV OR = 1.20). Additional factors associated with HBV alone were years of homosexual activity (OR = 1.65), sexual activity with a person who developed acquired immunodeficiency syndrome (AIDS) (OR = 1.98), and lifetime number of male sex partners (OR = 1.25). HIV and HBV coprevalence was associated with anal receptive intercourse (OR = 1.36), history of gonorrhea (OR = 2.94), rectal douching (OR = 1.45), sexual activity with a person who developed AIDS (OR = 3.87), lifetime number of male sex partners (OR = 1.21), and the lifetime sum of sexually transmitted diseases (OR = 1.47). These findings reinforce the need for following safer-sex guidelines to prevent both infections and in the case of HBV the prevention strategies should include vaccination. KW - homosexuality KW - human immunodeficiency viruses KW - mixed infections KW - risk factors KW - USA KW - hepatitis B virus KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - homosexuals KW - human immunodeficiency virus KW - multiple infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005089&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estrogen receptor status and dietary intakes in breast cancer patients. AU - Harlan, L. C. AU - Coates, R. J. AU - Block, G. AU - Greenberg, R. S. AU - Ershow, A. AU - Forman, M. AU - Austin, D. F. AU - Chen, V. AU - Heymsfield, S. B. JO - Epidemiology JF - Epidemiology Y1 - 1993/// VL - 4 IS - 1 SP - 25 EP - 31 SN - 1044-3983 AD - Harlan, L. C.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19931465513. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - The association between oestrogen receptor status and the intake of nutrients and food groups was studied in 689 black and white women 20 to 79 years old with breast cancer newly diagnosed in 1985 and 1986. Medical records were reviewed and interview data collected, including a 34-item food frequency questionnaire. Positive oestrogen receptor status was positively associated with age and inversely associated with parity and oral contraceptive use. White women were more likely to have oestrogen receptor-positive tumours. A high percentage of energy from fat was associated with oestrogen receptor-positive cancer and a high percentage from fat with receptor-negative cancer. The findings indicate that women with breast cancer who are on diets with a high proportion of energy from fat are more likely to have oestrogen receptor-positive tumours. KW - carbohydrates KW - diet KW - diet studies KW - ethnic groups KW - fats KW - mammary gland neoplasms KW - oestrogens KW - receptors KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - estrogens KW - mammary tumour KW - saccharides KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465513&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Patterns of pesticide use among farmers: implications for epidemiologic research. AU - Blair, A. AU - Zahm, S. H. JO - Epidemiology JF - Epidemiology Y1 - 1993/// VL - 4 IS - 1 SP - 55 EP - 62 SN - 1044-3983 AD - Blair, A.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Bethesda, MD 20892, USA. N1 - Accession Number: 19932023554. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Epidemiological studies from various countries suggest that farmers are at an increased risk from cancer. It has been suggested that this increased risk may be linked to pesticide exposure, although the validity and reliabilty of information on pesticide usage obtained by recall has often been questioned. A survey was carried out to investigate the accuracy with which both farmers and their surrogates recalled both the frequency and identity of the pesticides used. Surrogates were a poorer source of information than the farmers themselves and underreported both the number of pesticides used and the frequency of their use. Comparison of information on pesticides used between farmers and their pesticide suppliers showed a moderate level of correlation. Many farmers tend to use a small number of popular pesticides with a frequency of twice a year or less. Only 7% of farmers reported the use of 5 or more pesticides in any one year and 20% more than 5 herbicides. Over a 10-year period the same 5 insecticides accounted for more than 70% of use by weight, whereas the top 5 herbicides accounted for 68% of use by weight in 1971 and 82% in 1976. R.D. Verschoyle KW - agriculture KW - farmers KW - health hazards KW - Occupations KW - pesticides KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - United States of America KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pesticide exposures and multiple myeloma in Iowa men. AU - Brown, L. M. AU - Burmeister, L. F. AU - Everett, G. D. AU - Blair, A. JO - Cancer Causes and Control JF - Cancer Causes and Control Y1 - 1993/// VL - 4 IS - 2 SP - 153 EP - 156 AD - Brown, L. M.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19940803652. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A population-based case-control study of 173 white men with multiple myeloma (MM) and 650 controls was conducted in Iowa (USA), an area with a large farming population, to evaluate the association between MM, agricultural risk factors, and exposure to individual pesticides. A slight statistically non-significant elevated risk for MM was seen among farmers. Although slight excesses were observed, there was no significant associations between MM and handling either classes of pesticides or specific pesticides. This study found little evidence to suggest an association between risk of MM and farming or pesticides. KW - farmers KW - myeloma KW - neoplasms KW - occupational hazards KW - pesticides KW - poisoning KW - Iowa KW - USA KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancers KW - toxicosis KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803652&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary associations in a case-control study of endometrial cancer. AU - Potischman, N. AU - Swanson, C. A. AU - Brinton, L. A. AU - McAdams, M. AU - Barrett, R. J. AU - Berman, M. L. AU - Mortel, R. AU - Twiggs, L. B. AU - Wilbanks, G. D. AU - Hoover, R. N. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1993/// VL - 4 IS - 3 SP - 239 EP - 250 SN - 0957-5243 AD - Potischman, N.: Nutritional Epidemiology Section, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Suite 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401541. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - Despite the established role of obesity in the aetiology of endometrial neoplasms, limited data are available from analytical epidemiological studies on the association of risk with dietary factors. A case-control study of 399 cases and 296 controls conducted in 5 areas of the USA from 1 June 1987 to 15 May 1990, enables evaluation of risk related to dietary intakes adjusted for potential confounders. Energy intake was associated modestly with increased risk (odds ratio (OR) 1.5; 95% confidence interval (CI) 0.9-2.5 for highest vs. lowest quartiles of intake), with the principal contributors being fat and protein energy. After adjustment for other risk factors, including body mass, increased risk was associated with higher intakes of fat. Several components of fat investigated were associated with increased risk, although associations were slightly stronger for saturated fat (OR 2.1, CI 1.2-3.7) and oleic acid (OR 2.2, CI 1.2-4.0) than for linoleic acid (OR 1.6, CI 0.9-2.8). Food-group analyses showed intake of complex carbohydrates, and specifically of breads and cereals, associated with reduced risks (OR 0.6, CI 0.4 to 1.1), whereas animal fat and fried foods were associated with increased risks (OR 1.5 and 1.7, respectively). The relations of endometrial neoplasms with animal fat and complex carbohydrates were independent. No consistent associations were noted for intakes of cholesterol, fibre, retinol and ascorbic acid, individual carotenoids or folate-rich foods. The data imply an aetiologic role for a diet rich in total fat and/or animal fat and low in complex carbohydrates with endometrial neoplasms. These associations are consistent with a hormonal mechanism and were independent of the associations of obesity and other risk factors. KW - carbohydrates KW - carcinoma KW - diet studies KW - endometrium KW - fats KW - protein intake KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - endometrial area KW - saccharides KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401541&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Race and sex differences in associations of vegetables, fruits, and carotenoids with lung cancer risk in New Jersey (United States). AU - Dorgan, J. F. AU - Ziegler, R. G. AU - Schoenberg, J. B. AU - Hartge, P. AU - McAdams, M. J. AU - Falk, R. T. AU - Wilcox, H. B. AU - Shaw, G. L. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1993/// VL - 4 IS - 3 SP - 273 EP - 281 SN - 0957-5243 AD - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20892, USA. N1 - Accession Number: 19941401542. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - Data from a case-control study made in New Jersey, USA, between 1980 and 1983 were used to evaluate race and sex differences in associations of vegetable, fruit and carotenoid consumption with lung carcinoma. Cases included 736 white men, 860 white women, 269 black men and 86 black women with incident, histologically confirmed, primary neoplasms of the trachea, bronchus or lung. Controls were 548 white men, 473 white women, 170 black men and 47 black women. Usual intakes of vegetables (predominantly yellow/green) and fruit (predominantly yellow/orange) as well as other food sources of carotenoids were ascertained by a food frequency questionnaire. White women showed significant inverse associations of lung neoplasms with vegetables, fruit and carotenoids. White men showed non-significant inverse associations with vegetables and carotenoids, and black women just with vegetables. No inverse associations were found for black men. Vegetable consumption was associated with risk of all histologic types of lung neoplasms, but the pattern of increasing risk with decreasing intake was limited to smokers. It is inferred that consumption of yellow/green vegetables and carotenoids may confer protection from lung neoplasms to white men and white women smokers. Further studies are needed to clarify the effect in blacks. KW - carcinoma KW - carotenoids KW - diet studies KW - ethnic groups KW - fruit KW - intake KW - lungs KW - risk KW - sex differences KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - tetraterpenoids KW - United States of America KW - vegetable crops KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401542&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - dbEST - database for "expressed sequence tags". AU - Boguski, M. S. AU - Lowe, T. M. J. AU - Tolstoshev, C. M. JO - Nature Genetics JF - Nature Genetics Y1 - 1993/// VL - 4 IS - 4 SP - 332 EP - 333 SN - 1061-4036 AD - Boguski, M. S.: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, Room 8N-805, 8600 Rockville Pike, Bethesda, MD 20894, USA. N1 - Accession Number: 19950109837. Publication Type: Journal Article. Language: English. Number of References: 15 ref. N2 - This paper describes a new database that has been set up for partial, 'single-pass' cDNA sequences, also known as expressed sequence tags. Such sequences, and associated information, may be sent via E-mail or Internet to the National Center for Biotechnology Information. The database is available for public access. KW - databases KW - nucleotide sequences KW - rice KW - arabidopsis thaliana KW - caenorhabditis elegans KW - macropus eugenii KW - man KW - mice KW - Oryza KW - plasmodium falciparum KW - Rhabditida KW - Arabidopsis KW - Brassicaceae KW - Capparidales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Caenorhabditis KW - Rhabditidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - Macropus KW - Macropodidae KW - Diprotodontia KW - marsupials KW - mammals KW - vertebrates KW - Chordata KW - Homo KW - Hominidae KW - Primates KW - Muridae KW - rodents KW - Poaceae KW - Cyperales KW - monocotyledons KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Capparales KW - data banks KW - DNA sequences KW - nematodes KW - paddy KW - Secernentea KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950109837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occasional binges by moderate drinkers: implications for birth outcomes. AU - Tolo, K. A. AU - Little, R. E. JO - Epidemiology JF - Epidemiology Y1 - 1993/// VL - 4 IS - 5 SP - 415 EP - 420 SN - 1044-3983 AD - Tolo, K. A.: Epidemiology Branch, Mail Drop A3-05, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19941404329. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition N2 - The effects of occasional alcohol binges on birth outcomes were studied in a cohort of live singletons born to 709 moderate drinkers recruited from a health maintenance organization in Seattle, USA before their sixth month of pregnancy. Infants of women with one or more binges in the month before pregnancy or in the first trimesters were compared with those whose mothers reported no binges in either period. Mean values of birth weight, length, head circumference, gestational age, intrauterine growth and Apgar scores did not differ notably between the 2 groups. The risk of having an adverse neonatal discharge diagnosis initially appeared lower in infants of binging mothers, but this difference vanished after recategorization of the variable and control for confounding. The results indicate that occasional binges, during a broad window of exposure and among otherwise moderate drinkers, did not adversely affect the birth outcomes examined. KW - alcoholic beverages KW - birth weight KW - body measurements KW - fetal development KW - intake KW - mothers KW - neonates KW - pregnancy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gestation KW - newborn infants KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404329&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States). AU - Zheng, W. AU - McLaughlin, J. K. AU - Gridley, G. AU - Bjelke, E. AU - Schuman, L. M. AU - Silverman, D. T. AU - Wacholder, S. AU - Co-Chien, H. T. AU - Blot, W. J. AU - Fraumeni, J. F., Jr. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1993/// VL - 4 IS - 5 SP - 477 EP - 482 SN - 0957-5243 AD - Zheng, W.: Biostatistics Branch, National Cancer Institute, 6130 Executive Blvd., Room 415 Bethesda, MD 20892, USA. N1 - Accession Number: 19941406677. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition N2 - Risk factors for pancreatic neoplasms were evaluated in a cohort study of 17 633 white men in the USA who responded to a mailed questionnaire in 1966 and were followed-up to 1986 for mortality. Cigarette smoking and alcohol consumption were important risk factors for pancreatic neoplasms. Risks increased significantly with number of cigarettes smoked, reaching 4-fold for smokers of 25 or more cigarettes per day relative to non-smokers. Alcohol intake also was related significantly to risk, with consumers of 10 or more drinks per month having 3 times the risk of non-drinkers, but dose-response trends among drinkers were not smooth. Coffee consumption was unrelated to risk. Dietary analyses revealed a rising rate of pancreatic neoplasms mortality with increasing consumption of meat after adjustment for other risk factors. Men in the highest quartile of meat intake had about 3 times the risk of those in the lowest quartile. No consistent association, however, was observed for consumption of fruits, vegetables or grains. KW - alcoholic beverages KW - diet KW - men KW - neoplasms KW - pancreas KW - tobacco smoking KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406677&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Moderate alcohol consumption and the risk of endometrial cancer. AU - Swanson, C. A. AU - Wilbanks, G. D. AU - Twiggs, L. B. AU - Mortel, R. AU - Berman, M. L. AU - Barrett, R. J. AU - Brinton, L. A. JO - Epidemiology JF - Epidemiology Y1 - 1993/// VL - 4 IS - 6 SP - 530 EP - 536 SN - 1044-3983 AD - Swanson, C. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethedsa, MD, USA. N1 - Accession Number: 19941407499. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition N2 - In a multicentre case-control study that included 400 cases and 297 controls, the relation of moderate alcohol consumption to risk of endometrial carcinogenesis was studied. Average weekly intake of alcohol was estimated during adulthood from the reported frequency of intake of beer, wine and spirits. The relative risk of endometrial neoplasms was 0.82 (95% confidence interval = 0.6 to 1.2) among women who drank, compared with lifelong abstainers. The weak protective effect of alcohol was due to a stronger inverse association among young women (<55 years). In young women, the age-adjusted relative risks for 3 levels of drinking (<1, 1 to 4 and >4 drinks per week), from lowest to highest, were 0.78, 0.64 and 0.41 compared with non-drinkers. The risk estimates were not materially altered after adjustment for a variety of factors related to alcohol intake and to low risk of the disease (for example, smoking, oral contraceptive use, low body mass index, increased physical activity). The protective effect of alcohol could not be attributed to 1 particular type of alcohol-containing beverage, but beer appeared to have the most pronounced effect. These results suggest an inverse association between moderate alcohol consumption and endometrial neoplasm risk among young women, but support for a causal association is qualified and requires confirmation. KW - alcoholic beverages KW - carcinoma KW - endometrium KW - intake KW - neoplasms KW - risk KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - endometrial area KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407499&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The 6th Annual Meeting of NCVDG for AIDS. AU - Limpakanjanarat, K. AU - Makonkawkeyoon, S. JO - Thai AIDS Journal JF - Thai AIDS Journal Y1 - 1993/// VL - 5 IS - 3 SP - 113 EP - 120 SN - 0857-8575 AD - Limpakanjanarat, K.: Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Thailand. N1 - Accession Number: 19942050904. Publication Type: Journal Article. Corporate Author: Thailand, Cooperative Vaccine Development Groups (NCVDG) for AIDS Language: Thai. N2 - A review for Thai readers. KW - acquired immune deficiency syndrome KW - HIV infections KW - prevention KW - research KW - vaccines KW - Thailand KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - AIDS KW - human immunodeficiency virus infections KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effector functions of activated macrophages against parasites. AU - James, S. L. AU - Nacy, C. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1993/// VL - 5 IS - 4 SP - 518 EP - 523 SN - 0952-7915 AD - James, S. L.: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802191. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Helminthology; Protozoology; Tropical Diseases; Public Health N2 - The role of activated macrophages as a major effector cell of anti-parasitic immunity is reviewed with regard to: induction of macrophage cytotoxic activity; effector reactions; downregulation of activated macrophage effector reactions. The contribution of research on cytokine function to the understanding of the immune mechanisms regulating murine macrophage function, and the effector molecules employed by these cells to kill both intracellular and extracellular parasites, is discussed. KW - cytokines KW - helminths KW - human diseases KW - immune response KW - macrophages KW - parasites KW - reviews KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802191&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission-blocking immunity against malaria and other vector-borne diseases. AU - Kaslow, D. C. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1993/// VL - 5 IS - 4 SP - 557 EP - 565 SN - 0952-7915 AD - Kaslow, D. C.: Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B1-37, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802196. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases N2 - This review covers: the biological basis of malaria transmission-blocking vaccines (immunogenicity of gametocyte target antigens, antigenic diversity of gametocyte target antigens, boosting with subsequent natural infection); gametocyte/gamete (pre-fertilization) target antigens (Pf11.1/Pfs2400, Pfs230, Pfs48/45, Pfs40, Pfg27/25, Pfs16); zygote/early ookinete (post-fertilization) target antigens (Pfs25, Pfs28/Pgs28/Pbs21); late midgut stage (late ookinete/oocyst) target antigens (chitinase, mosquito-produced protease); targets for other vector-borne diseases (anti-mosquito antigen vaccines, anti-tick midgut vaccines). KW - human diseases KW - malaria KW - parasites KW - reviews KW - transmission blocking immunity KW - vector-borne diseases KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802196&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of fibroblast hyaluronic acid production by suramin. AU - August, E. M. AU - Duncan, K. L. K. AU - Malinowski, N. M. AU - Cysyk, R. L. JO - Oncology Research JF - Oncology Research Y1 - 1993/// VL - 5 IS - 10/11 SP - 415 EP - 422 SN - 0965-0407 AD - August, E. M.: Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5E10, Bethesda, MD 20892, USA. N1 - Accession Number: 19940805373. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9004-61-9, 145-63-1. Subject Subsets: Helminthology KW - anthelmintics KW - helminths KW - hyaluronic acid KW - inhibition KW - parasites KW - suramin KW - parasitic worms KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805373&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The National Health and Nutrition Examination Survey III: describing the health and nutritional status of older Americans. AU - Harris, T. AU - Burt, V. L. AU - Briefel, R. R. AU - McDowell, M. AU - Sorenson, A. W. JO - Aging, Clinical and Experimental Research JF - Aging, Clinical and Experimental Research Y1 - 1993/// VL - 5 IS - 2, SUPP 1 SP - 29 EP - 36 SN - 0394-9532 AD - Harris, T.: National Institute on Aging, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402150. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition N2 - A brief overview of the nutritional content of the National Health and Nutrition Survey III (NHANES III) in the USA is provided. KW - diet studies KW - nutrition surveys KW - old age KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Nutrition and aging - current issues and future imperatives KW - nutritional surveys KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402150&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recommendations for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus. JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1993/// VL - 6 IS - 1 SP - 46 EP - 55 SN - 0894-9255 AD - H. Masur, National Institutes of Health, Building 10, Room 7043, Bethesda, MD 20892, USA. N1 - Accession Number: 19930883161. Publication Type: Journal Article. Corporate Author: US Public Health Service Task Force on Antipneumocystis Prophylaxis in Patients with Human Immunodeficiency Virus Language: English. Number of References: 36 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology N2 - The Task Force set up in 1989 by the US Public Health Service to consider the expanding knowledge base about prevention of Pneumocystis carinii pneumonia (PCP) in adults with human immunodeficiency virus (HIV) infection was reconvened in October 1991 to consider information that has become available since the first report about the efficacy and safety of aerosolized pentamidine, oral trimethoprim sulfamethoxazole (TMP-SMX), and the importance of prospective monitoring of CD4+ cell counts. The revised recommendations are set out under the following headings : Is prophylaxis for PCP desirable?; How should patients be monitored to determine if they are at increased risk of PCP?; Who should receive prophylaxis for PCP (primary prophylaxis, secondary prophylaxis)?; What prophylactic regimens are proven to be safe and effective and how should they be administered (TMP-SMX, aerosol pentamidine, other drugs)?; Which form of prophylaxis is best?; Management of prophylaxis-related toxicity; Need for close monitoring of patients receiving prophylaxis; If a patient develops an episode of PCP while receiving prophylaxis, what regimen should be used for treating the acute episode and what prophylactic regimen should be resumed after successful completion of acute therapy? What is recommended for children? Do any prophylactic regimens against PCP also provide protection against other opportunistic infections? Cost of PCP prophylaxis. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - guidelines KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - lungs KW - opportunistic infections KW - parasites KW - predisposition KW - prophylaxis KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - recommendations KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930883161&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bladder cancer and bilharziasis today. AU - Khaled, H. M. JO - Cancer Journal JF - Cancer Journal Y1 - 1993/// VL - 6 IS - 2 SP - 65 EP - 71 SN - 0765-7846 AD - Khaled, H. M.: Medical Oncology Department, National Cancer Institute, Fom El-Khalig Square, Cairo, Egypt. N1 - Accession Number: 19950803554. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Helminthology N2 - This review article examines the current position of bladder cancer and its association with schistosomiasis. The geographical distribution and life cycle of Schistosoma are discussed followed by a consideration of the aetiological relationship between bladder cancer and Schistosoma, the effect of schistosomiasis on the host immune system, and the pathology and natural history of bladder cancer. The second half of the article is concerned with the treatment of bladder cancer, essentially radical cystectomy and radiotherapy, and its early detection and prevention. KW - bladder diseases KW - carcinoma KW - helminths KW - human diseases KW - parasites KW - reviews KW - schistosomiasis KW - Digenea KW - man KW - Schistosoma KW - Schistosomatidae KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - general account KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 infection of the brain. AU - Atwood, W. J. AU - Berger, J. R. AU - Kaderman, R. AU - Tornatore, C. S. AU - Major, E. O. JO - Clinical Microbiology Reviews JF - Clinical Microbiology Reviews Y1 - 1993/// VL - 6 IS - 4 SP - 339 EP - 366 SN - 0893-8512 AD - Atwood, W. J.: Section on Molecular Virology and Genetics, Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19942026323. Publication Type: Journal Article. Language: English. Number of References: 389 ref. Subject Subsets: Public Health N2 - This extensive review covers the life cycle of HIV, clinical manifestations of CNS infection with HIV-1, neurotropism, pathogenesis, diagnosis and treatment. D.W. FitzSimons KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - brain KW - Central nervous system KW - Clinical aspects KW - Diagnosis KW - HIV infections KW - infections KW - nervous system KW - Neurology KW - Paediatrics KW - Pathogenesis KW - pathology KW - reviews KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - cerebrum KW - clinical picture KW - CNS KW - human immunodeficiency virus infections KW - Human immunodeficiency virus type 1 KW - neuropathology KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026323&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Measurement of cerebrospinal fluid antibody to the HIV-1 principal neutralizing determinant (V3 loop). AU - Lucey, D. R. AU - VanCott, T. C. AU - et al. AU - Loomis, L. D. ( JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1993/// VL - 6 IS - 9 SP - 994 EP - 1001 SN - 0894-9255 AD - Lucey, D. R.: Experimental Immunology Branch/NCI, Building 10, Room 4B-17, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004703. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - Antibodies KW - Cerebrospinal fluid KW - glycoproteins KW - HIV infections KW - Immune response KW - Immunology KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Intrathecal antibody production KW - V3 loop KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004703&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of intravenous immunoglobulin (IVIG) on CD4+ lymphocyte decline in HIV-infected children in a clinical trial of IVIG infection prophylaxis. AU - Mofenson, L. M. AU - Bethel, J. AU - Moye, J. Jr AU - Flyer, P. AU - Nugent, R. JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1993/// VL - 6 IS - 10 SP - 1103 EP - 1113 SN - 0894-9255 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Building 6100, Room 4B11, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004742. Publication Type: Journal Article. Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group Language: English. Registry Number: 308067-57-4. KW - HIV infections KW - Immunoglobulins KW - Paediatrics KW - Passive immunization KW - Treatment KW - gamma-globulins KW - human immunodeficiency virus infections KW - immune globulins KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fusogenicity of mutant and chimeric proviruses derived from molecular clones of cytopathic and noncytopathic human immunodeficiency virus type 2. AU - Arya, S. K. AU - Sadaie, M. R. JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1993/// VL - 6 IS - 11 SP - 1205 EP - 1211 SN - 0894-9255 AD - Arya, S. K.: Laboratory of Tumor Cell Biology, Bldg 37, Rm 6A09, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19942004912. Publication Type: Journal Article. Language: English. KW - Conformation KW - Cytopathogenicity KW - Envelope glycoproteins KW - Pathogenesis KW - Human immunodeficiency virus 2 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - body conformation KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942004912&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetic modeling of selenium in humans using stable isotope tracers. AU - Patterson, B. H. AU - Zech, L. A. AU - Swanson, C. A. AU - Levander, O. A. JO - Journal of Trace Elements and Electrolytes in Health and Disease JF - Journal of Trace Elements and Electrolytes in Health and Disease Y1 - 1993/// VL - 7 IS - 2 SP - 117 EP - 120 SN - 0931-2838 AD - Patterson, B. H.: Biometry Branck, DCPC, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941409219. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - The pharmacokinetics of selenium was investigated in 38 subjects who each received a single 200 µg dose of selenium as sodium selenite or as L-selenomethionine (SeMet). Plasma, urine and faeces were collected for 2 weeks. 2 kinetic models, 1 for each form, were developed. The Selenite Model included absorption distributed along the GI tracts, transport through 4 plasma components, a subsystem consisting of the liver and pancreas and a slowly turning-over tissue pool. This model was used as a starting model for SeMet and modified. The amount of label absorbed was increased as was hepato-pancreatic uptake, a pathway from the plasma back to the liver was added that provided for recycling of label, and an additional tissue pool was incorporated into the model. Turnover times were shorter for SeMet than for selenite for the plasma, liver and pancreas, and the tissues, but far longer for the whole body; this reflects the recycling of SeMet, but not of selenite. Such reutilization could be advantageous as it allows the body to redistribute Se. KW - adults KW - pharmacokinetics KW - selenium KW - trace elements KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - microelements KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409219&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of dnaJ, dnaK, and grpE homologues from Borrelia burgdorferi and complementation of Escherichia coli mutants. AU - Tilly, K. AU - Hauser, R. AU - Campbell, J. AU - Ostheimer, G. J. JO - Molecular Microbiology JF - Molecular Microbiology Y1 - 1993/// VL - 7 IS - 3 SP - 359 EP - 369 SN - 0950-382X AD - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19940500136. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - The heat-shock proteins DnaJ, DnaK and GrpE are involved in the replication of various species of DNA in E. coli, in addition to their roles in other processes, including protein disaggregation and export. The B. burgdorferi homologues of these genes were cloned. DNA sequence analysis revealed an open reading frame encoding a protein that is 62% identical to the E. coli DnaK protein. Genes homologous to the E. coli grpE and dnaJ genes, encoding products 28 and 39% identical to their homologues, are located up- and downstream, respectively, of the B. burgdorferi dnaK gene. No obvious promoters were detected in the sequenced DNA, although a potential transcription terminator was found downstream of the dnaJ gene, so these 3 genes may form an operon, perhaps with a fourth gene located upstream of the grpE gene. The grpE homologue complemented an E. coli grpE mutant and the dnaJ homologue complemented an E. coli dnaJ mutant, whereas the B. burgdorferi dnaK gene did not complement dnaK mutants. KW - clones KW - DNA KW - genes KW - heat shock proteins KW - molecular genetics KW - nucleotide sequences KW - operons KW - Borrelia burgdorferi KW - Escherichia coli KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - E. coli KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500136&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Filarial infections. AU - Ottesen, E. A. JO - Infectious Disease Clinics of North America JF - Infectious Disease Clinics of North America Y1 - 1993/// VL - 7 IS - 3 SP - 619 EP - 633 SN - 0891-5520 AD - Ottesen, E. A.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940802397. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Helminthology N2 - This review of human filarial infections covers: recent clinical advances (clinical presentations, diagnosis, treatment, chemoprophylaxis); specific clinical problems (evaluation of the patient with asymptomatic eosinophilia for suspected filarial infection, treatment of the asymptomatic patient, treatment of patients with lymphatic filariasis (Wuchereria bancrofti or Brugia malayi), treatment of patients with loiasis, treatment of patients with onchocerciasis, advice to travellers about antifilarial prophylaxis, management of "nonpathogenic" filarial infections). KW - filariids KW - helminths KW - human diseases KW - parasites KW - reviews KW - Brugia malayi KW - Loa loa KW - man KW - Mansonella KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - Wuchereria KW - African eyeworm KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802397&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Management of immunocompromised patients with evidence of an invasive mycosis. AU - Walsh, T. J. JO - Hematology/Oncology Clinics of North America JF - Hematology/Oncology Clinics of North America Y1 - 1993/// VL - 7 IS - 5 SP - 1003 EP - 1026 SN - 0889-8588 AD - Walsh, T. J.: Pediatric Branch, Infectious Disease Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200812. Publication Type: Journal Article. Language: English. Number of References: 112 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The management of immunocompromised patients with evidence of invasive mycosis is reviewed. The treatment of infections caused by Candida spp. (mucosal candidosis, candidaemia, disseminated candidosis, pulmonary candidosis), Aspergillus spp. (invasive pulmonary aspergillosis, extrapulmonary aspergillosis), emerging opportunistic mycoses due to Fusarium spp., Trichosporon beigelii, agents of zygomycosis, Pseudallescheria boydii, Scedosporium spp., agents of phaeohyphomycosis, Malassezia furfur and Cryptococcus neoformans, and endemic mycoses due to Coccidioides immitis and Histoplasma capsulatum is discussed. Empiric antifungal therapy and the use of recombinant human cytokines in the management of granulocytopenic patients are considered. KW - antifungal agents KW - aspergillosis KW - candidosis KW - coccidioidomycosis KW - cryptococcosis KW - cytokines KW - drug therapy KW - fusariosis KW - histoplasmosis KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - immunotherapy KW - infections KW - mycoses KW - opportunistic infections KW - phaeohyphomycosis KW - predisposition KW - reviews KW - therapy KW - zygomycosis KW - Aspergillus KW - Candida KW - Coccidioides immitis KW - Cryptococcus neoformans KW - Fusarium KW - Histoplasma capsulatum KW - Malassezia furfur KW - man KW - Pseudallescheria boydii KW - Scedosporium KW - Trichosporon beigelii KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Histoplasma KW - Malassezia KW - Malasseziales KW - Ustilaginomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporon KW - Trichosporonaceae KW - Ajellomyces capsulatus KW - candidiasis KW - chemotherapy KW - chromomycosis KW - coccidiomycosis KW - european blastomycosis KW - fungistats KW - fungus KW - fusarioses KW - Hyphomycetes KW - phycomycosis KW - therapeutics KW - trichosporonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cellular immune factors associated with mother-to-infant transmission of HIV. AU - Clerici, M. AU - Sison, A. V. AU - et al. AU - Berzofsky, J. A. ( AU - Shearer, G. M. JO - AIDS JF - AIDS Y1 - 1993/// VL - 7 IS - 11 SP - 1427 EP - 1433 SN - 0269-9370 AD - Clerici, M.: (G.M. Shearer) Experimental Immunology Branch, National Cancer Institute, Building 10, Room 4B-17, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004980. Publication Type: Journal Article. Language: English. KW - Cell mediated immunity KW - HIV infections KW - Maternal transmission KW - T lymphocytes KW - cellular immunity KW - human immunodeficiency virus infections KW - mother to child transmission KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004980&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Taxonomic status of Blastocystis hominis: reply. AU - Zierdt, C. H. T2 - Parasitology Today JO - Parasitology Today JF - Parasitology Today Y1 - 1993/// VL - 9 IS - 1 SP - 18 EP - 18 AD - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Building 10, Room 2C-343, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930803168. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Subject Subsets: Protozoology N2 - In reply to the paper by Jiang and He (Parasitology Today (1993) 9 (1), 2-3), Zierdt outlines previous classifications of Blastocystis hominis and discusses the establishment of a separate classification for the parasite. The author agrees with the classification of a new subphylum (Blastocysta) proposed by Jiang and He but argues that it is difficult to state that 3 forms evolved from the evolutionarily earlier vacuolated form, since all can interchange in a single culture. It is suggested that caution must be exercised in assigning new cell form status as it may reflect structural response to nutritional changes. KW - life history KW - new subphylum KW - parasites KW - Taxonomy KW - Blastocystis hominis KW - protozoa KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Blastocysta KW - systematics KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930803168&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chitinase: a novel target for blocking parasite transmission? AU - Shahabuddin, M. AU - Kaslow, D. C. JO - Parasitology Today JF - Parasitology Today Y1 - 1993/// VL - 9 IS - 7 SP - 252 EP - 255 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808105. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 9001-06-3. Subject Subsets: Helminthology; Protozoology; Medical & Veterinary Entomology N2 - The possible role of chitinase in the transmission (through their insect hosts) of Plasmodium, Leishmania, Brugia, Onchocerca and Trypanosoma is discussed. The parasites for which chitinase has been reported are listed in a table. It is suggested that the enzymes involved in chitin metabolism could be suitable candidates for vaccine development. KW - Biochemistry KW - chitinase KW - Enzymes KW - helminths KW - parasites KW - vaccines KW - Apicomplexa KW - Brugia KW - Leishmania KW - Nematoda KW - Onchocerca KW - Onchocercidae KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Sarcomastigophora KW - Trypanosoma KW - Trypanosomatidae KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808105&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutational analysis of the assembly domain of the HIV-1 envelope glycoprotein. AU - Earl, P. L. AU - Moss, B. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1993/// VL - 9 IS - 7 SP - 589 EP - 594 SN - 0889-2229 AD - Earl, P. L.: Laboratory of Viral Diseases, Building 4, Room 237, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004608. Publication Type: Journal Article. Language: English. KW - envelope protein gp41 KW - human immunodeficiency viruses KW - Molecular biology KW - Mutational analysis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Env KW - gp41 KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Oligomerization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004608&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - How the discovery of Borrelia burgdorferi came about. AU - Burgdorfer, W. A2 - Åsbrink, E. A2 - Hovmark, A. JO - Clinics in Dermatology JF - Clinics in Dermatology Y1 - 1993/// VL - 11 IS - 3 SP - 335 EP - 338 SN - 0738-081X AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19940501409. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology KW - history KW - Lyme disease KW - reviews KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodes ricinus KW - Ixodes scapularis KW - man KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - bacterium KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940501409&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunogenicity of a synthetic oligopeptide corresponding to antigenically common T-helper and B-cell neutralizing epitopes of the major outer membrane protein of Chlamydia trachomatis. AU - Su, H. AU - Caldwell, H. D. JO - Vaccine JF - Vaccine Y1 - 1993/// VL - 11 IS - 11 SP - 1159 EP - 1166 SN - 0264-410X AD - Su, H.: (H.D. Caldwell) National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19942025343. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A study using mice and cynomolgus monkeys. KW - antigens KW - Chlamydia trachomatis KW - Chlamydia KW - Chlamydiaceae KW - Chlamydiales KW - Chlamydiae KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - experimental vaccines KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025343&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccinees and vaccinia virus recombinants that express the surface glycoproteins of RSV. AU - Crowe, J. E. Jr AU - Collins, P. L. AU - London, W. T. AU - Chanock, R. M. AU - Murphy, B. R. JO - Vaccine JF - Vaccine Y1 - 1993/// VL - 11 IS - 14 SP - 1395 EP - 1404 SN - 0264-410X AD - Crowe, J. E. Jr: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942025395. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - comparisons KW - efficacy KW - infections KW - live vaccines KW - recombinant vaccines KW - human respiratory syncytial virus KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - viruses KW - attenuated vaccines KW - immunogenicity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025395&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pulmonary cryptococcosis presenting as metastases in children with sarcomas. AU - Allende, M. AU - Pizzo, P. A. AU - Horowitz, M. AU - Pass, H. I. AU - Walsh, T. J. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1993/// VL - 12 IS - 3 SP - 240 EP - 243 SN - 0891-3668 AD - Allende, M.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931251740. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - Four cases are reported in 11, 15 and 16-yr-old boys and an 8-yr-old girl, all with sarcomas in remission, who developed asymptomatic pulmonary nodules presumed to be new pulmonary metastases from the solid primary tumour. All patients underwent a thoracotomy with excisional biopsy and the fully resected lesions were proved to be caused by Cryptococcus neoformans by culture with histopathological confirmation. Two patients received systemic antifungal therapy with fluconazole (400 mg/d) or ketoconazole (400 mg/d) and 2 patients were treated with surgical resection only. No patient subsequently developed a relapse of solid tumour or cryptococcosis. KW - children KW - Cryptococcosis KW - hosts KW - infections KW - lungs KW - neoplasms KW - predisposition KW - sarcoma KW - North America KW - USA KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - european blastomycosis KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251740&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Women's health and nutrition research: US governmental concerns. AU - Cummings, N. B. JO - Journal of the American College of Nutrition JF - Journal of the American College of Nutrition Y1 - 1993/// VL - 12 IS - 4 SP - 329 EP - 336 SN - 0731-5724 AD - Cummings, N. B.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940404577. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition KW - health KW - nutrition KW - nutrition research KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404577&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Healthy adiposity in women: the Framingham Offspring Study. AU - Garrison, R. J. JO - Journal of the American College of Nutrition JF - Journal of the American College of Nutrition Y1 - 1993/// VL - 12 IS - 4 SP - 357 EP - 362 SN - 0731-5724 AD - Garrison, R. J.: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940404574. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - A threshold for "healthy adiposity" was estimated by examining the relation between subscapular skinfolds thickness, a direct measure of adiposity, and cardiovascular disease risk factors in 1254 nonsmoking women who participated in the Framingham Offspring Study (USA). Cardiovascular disease risk factors, including blood pressure, fasting plasma lipoprotein cholesterol, plasma glucose and echocardiographically measured left ventricular mass were included. The optimal subscapular skinfold for women 20 to 39 years old was <15 mm. Women 20 to 59 years old whose subscapular skinfolds were below this level had a mean body mass index (BMI) of 21.1 kg/m². Weight-for-height estimates for these women corresponded closely to the 1959 Metropolitan Life Insurance Company Desirable Weight table. The probability of having unhealthy adiposity was estimated for all women 20 to 59 years old for each (rounded) integer value grouping BMI. The probability of being above the healthy adiposity threshold increased rapidly across BMI levels >20 and plateaued >24. Thus, only women with BMI <24 need assessment for adiposity status. KW - body composition KW - body fat KW - body measurements KW - cardiovascular diseases KW - nutrition surveys KW - risk KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - nutritional surveys KW - United States of America KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404574&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Primum non nocere: a pharmacologically inert pertussis toxoid alone should be the next pertussis vaccine. AU - Robbins, J. B. AU - Pittman, M. AU - Trollfors, B. AU - Lagergard, T. A. AU - Taranger, J. AU - Schneerson, R. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1993/// VL - 12 IS - 10 SP - 795 EP - 807 SN - 0891-3668 AD - Robbins, J. B.: National Institute of Child Health and Human Development, Laboratory and Developmental and Molecular Immunity, Building 6, Room 145, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028106. Publication Type: Journal Article. Language: English. Number of References: 240 ref. Subject Subsets: Public Health N2 - A review. KW - immunization KW - Pertussis KW - reviews KW - immune sensitization KW - whooping cough KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An analysis of AIDS incidence data by clustering trends. AU - Kafadar, K. AU - Karon, J. M. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1993/// VL - 12 IS - 3/4 SP - 311 EP - 326 SN - 0277-6715 AD - Kafadar, K.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020838. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The purpose of this paper is to group metropolitan areas in the USA according to the shape of the AIDS epidemic curve reported from each area. Only areas with a population of 1 million and reporting at least 400 AIDS cases are considered. By using cluster analysis the authors derived a dendrogram which suggests five different patterns of AIDS incidence (the distance measure between two areas was the variance of trimester-specific ratios of the smoothed number of reported AIDS cases). The authors suggest that modelling procedures may be more accurate if based on the groups so defined rather than one based on the overall data.D. Dunn KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - cluster analysis KW - Epidemiology KW - HIV infections KW - homosexuality KW - Incidence KW - mathematical models KW - men KW - Statistics KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - America (North) KW - Epidemic trends KW - homosexuals KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020838&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Case report of anorexia nervosa associated with Wilson's disease. AU - Gwirtsman, H. E. AU - Prager, J. AU - Henkin, R. JO - International Journal of Eating Disorders JF - International Journal of Eating Disorders Y1 - 1993/// VL - 13 IS - 2 SP - 241 EP - 244 SN - 0276-3478 AD - Gwirtsman, H. E.: Mood, Anxiety and Personality Disorders Research Branch, Division of Clinical Research, National Institute of Mental Health, Room 10C-24, 5600 Fisher Lane, Rockville, MD 20857, USA. N1 - Accession Number: 19941402854. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 7440-50-8. Subject Subsets: Human Nutrition KW - anorexia nervosa KW - case reports KW - copper KW - mineral metabolism disorders KW - nervous system diseases KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - neuropathy KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402854&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An attempt to modify unhealthful eating attitudes and weight regulation practices of young adolescent girls. AU - Killen, J. D. AU - Taylor, C. B. AU - Hammer, L. D. AU - Litt, I. AU - Wilson, D. M. AU - Rich, T. AU - Hayward, C. AU - Simmonds, B. AU - Kraemer, H. AU - Varady, A. JO - International Journal of Eating Disorders JF - International Journal of Eating Disorders Y1 - 1993/// VL - 13 IS - 4 SP - 369 EP - 384 SN - 0276-3478 AD - Killen, J. D.: National Institute of Child Health and Human Development, 6100 Executive Blvd., Bethesda, MD 20852, USA. N1 - Accession Number: 19941404233. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - A study evaluating the effectiveness of a prevention curriculum designed to modify eating attitudes and unhealthy weight regulation practices of 967 girls (11 to 13 years old) is described. Prevention intervention was developed around the following principal components: instruction on the harmful effects of unhealthy weight regulation; promotion of healthy weight regulation through the practice of sound nutrition and dietary principles and regular aerobic physical activity; and development of coping skills for resisting the diverse sociocultural influences that appear linked to current popular obsessions with thinness and dieting. A significant increase in knowledge among girls receiving the intervention was observed and among high-risk students only, there was a small significant effect on body mass index. The findings question the wisdom of providing a curriculum directed at all young adolescents, most of whom are not at risk to develop an eating disorder. It is suggested that rather than targeting the entire population, a healthy weight curriculum designed to modify eating attitudes and unhealthy weight regulation practices of young adolescent girls might better focus on "at risk" students. KW - adolescents KW - appetite disorders KW - behaviour KW - body weight KW - children KW - diet KW - feeding behaviour KW - girls KW - nutrition education KW - prevention KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - eating disorders KW - feeding behavior KW - teenagers KW - Animal Behaviour (LL300) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404233&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Opportunistic/nosocomial infections. Treatment and developmental therapeutics. I. Cryptococcosis. AU - St. Georgiev, V. JO - Medicinal Research Reviews JF - Medicinal Research Reviews Y1 - 1993/// VL - 13 IS - 4 SP - 493 EP - 506 SN - 0198-6325 AD - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200761. Publication Type: Journal Article. Language: English. Number of References: 148 ref. Registry Number: 1397-89-3, 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - The treatment of Cryptococcus neoformans infections is reviewed, including clinical signs of cryptococcosis, use of amphotericin B, combinations of amphotericin B with 5-fluorocytosine [flucytosine] and other drugs, and amphotericin B esters. KW - amphotericin B KW - antifungal agents KW - cryptococcosis KW - drug combinations KW - drug therapy KW - flucytosine KW - human diseases KW - infections KW - reviews KW - therapy KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 5-fluorocytosine KW - chemotherapy KW - european blastomycosis KW - fungistats KW - fungus KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. AU - Gatignol, A. AU - Buckler, C. AU - Jeang, K. T. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1993/// VL - 13 IS - 4 SP - 2193 EP - 2202 SN - 0270-7306 AD - Gatignol, A.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19942025037. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Registry Number: 63231-63-0. KW - Genes KW - human immunodeficiency viruses KW - Molecular biology KW - Nucleotide sequences KW - RNA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Binding protein KW - DNA sequences KW - HUMAN IMMUNODEFICIENCY VIRUS KW - ribonucleic acid KW - TAR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025037&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Opportunistic/nosocomial infections. Treatment and developmental therapeutics. Toxoplasmosis. AU - Georgiev, V. St. JO - Medicinal Research Reviews JF - Medicinal Research Reviews Y1 - 1993/// VL - 13 IS - 5 SP - 529 EP - 568 SN - 0198-6325 AD - Georgiev, V. St.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Bldg., Room 4C-39, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804403. Publication Type: Journal Article. Language: English. Number of References: 335 ref. Subject Subsets: Protozoology N2 - This review covers: management of ocular toxoplasmosis; mode of action and pharmacokinetics of sulfonamides and antifolate drugs; pyrimethamine-sulfonamide combinations; trimethoprim-sulfonamide combinations; miscellaneous sulfonamides; antibiotic therapy of toxoplasmosis (spiramycin, clindamycin, clindamycin-pyrimethamine combinations, roxithromycin, azithromycin); robenidine; trimetrexate and related compounds; purine analogues; miscellaneous derivatives with antitoxoplasma activity; role of cell-mediated immunity in the therapy of toxoplasmosis; drug-resistant mutants of Toxoplasma gondii. KW - antiprotozoal agents KW - drug therapy KW - human diseases KW - parasites KW - reviews KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - chemotherapy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804403&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anaphylactoid reaction with suramin. AU - Thibault, A. AU - Figg, W. D. AU - Cooper, M. R. AU - Prindiville, S. A. AU - Sartor, A. O. AU - Headlee, D. J. AU - Myers, C. E. JO - Pharmacotherapy JF - Pharmacotherapy Y1 - 1993/// VL - 13 IS - 6 SP - 656 EP - 657 SN - 0277-0008 AD - Thibault, A.: Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803227. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 145-63-1. Subject Subsets: Protozoology; Helminthology N2 - A 73-year-old man had an anaphylactoid reaction following the first dose of suramin (15.9 mg/kg, total dose 1500 mg infused over 1 h, given as a treatment for metastatic prostate cancer). It was treated successfully with epinephrine, diphenhydramine, and hydrocortisone. KW - anaphylaxis KW - helminths KW - parasites KW - suramin KW - toxicity KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - anaphylactic reactions KW - anaphylactic shock KW - parasitic worms KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803227&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New tetrahydrobiopterin-dependent systems. AU - Kaufman, S. JO - Annual Review of Nutrition JF - Annual Review of Nutrition Y1 - 1993/// VL - 13 SP - 261 EP - 286 SN - 0199-9885 AD - Kaufman, S.: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941406248. Publication Type: Journal Article. Language: English. Number of References: 119 ref. Registry Number: 22150-76-1. Subject Subsets: Human Nutrition N2 - This review of the role played by tetrahydrobiopterin-dependent systems covers the following areas: Role of tetrahydrobiopterin (BH4) as the coenzyme for the aromatic amino acid hydroxylases; Phenylketonuria and its variants; BH4 and cell proliferation; BH4 and cell-mediated immunity; and BH4 as a neurotransmitter-releasing factor. KW - amino acid metabolism KW - biopterin KW - cell mediated immunity KW - cells KW - coenzymes KW - growth KW - hyperphenylalaninaemia KW - neurotransmitters KW - phenylketonuria KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cellular immunity KW - hyperphenylalaninemia KW - Phenylalanine hydroxylase deficiency KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406248&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A TH1->TH2 switch is a critical step in the etiology of HIV infection. AU - Clerici, M. AU - Shearer, G. M. JO - Immunology Today JF - Immunology Today Y1 - 1993/// VL - 14 IS - 3 SP - 107 EP - 111 SN - 0167-4919 AD - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020571. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health N2 - The authors propose, from their work and others', that TH1-type responses are immunoprotective and that seroconversion and detection of viral DNA in blood cells correlates with a transition from a preliminary TH1 state to a TH2 bias in response to HIV. The implications for vaccine strategies are discussed; low-dose immunization, preferentially inducing cellular immunity, may be advantageous. KW - Cell mediated immunity KW - Cytokines KW - disease course KW - HIV infections KW - Immunology KW - interleukins KW - Regulation KW - research KW - T lymphocytes KW - vaccines KW - cellular immunity KW - disease progression KW - Helper T cells KW - helper T-cell function KW - human immunodeficiency virus infections KW - Immune function KW - studies KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Research (AA500) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020571&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice. AU - Luca, L. M. de AU - Sly, L. AU - Jones, C. S. AU - Chen, L. C. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1993/// VL - 14 IS - 3 SP - 539 EP - 542 SN - 0143-3334 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19941404928. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - A study was conducted to evaluate the effect of dietary retinoic acid (RA) on papilloma formation and the conversion of papillomas to carcinomas. Skin tumours were induced in 3 week old female SENCAR mice by an application of 7,12-dimethylbenz(a)anthracene (DMBA) 20 µg, followed by 20 weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) 10 µg. Mice were given RA 0.3 (nutritionally marginal dose), 3 (near physiological) and 30 (pharmacological) µg/g diet. Mice fed RA 30 µg/g diet had the same survival rate as the other 2 groups despite a lower body weight and all groups had similar papilloma incidence, which reached 100% at 18 weeks old. Mice fed on RA 3 µg/g diet had the highest papilloma yield (about 14 papillomas/mouse) and it peaked between 18 and 38 weeks old. These papillomas later regressed such that mice from all groups had about the same papilloma yield at 44 weeks old. Mice fed RA 30 µg/g diet failed to develop any visible carcinoma, while mice fed on 0.3 or 3 µg/g showed 1.9% conversion of papillomas to carcinomas. Therefore, dietary RA at 30 µg/g diet inhibited the conversion of papillomas to carcinomas without affecting papilloma incidence. In addition, dietary RA 30 and 0.3 µg/g diet lowered papilloma yield. KW - carcinoma KW - intake KW - retinoic acid KW - skin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dermis KW - tretinoin KW - vitamin A acid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404928&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of varying the onset of exposure to DDT on its modulation of AFB1-induced hepatocarcinogenesis in the rat. AU - Rojanapo, W. AU - Kupradinum, P. AU - Tepsuwan, A. AU - Tanyakaset, M. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1993/// VL - 14 IS - 4 SP - 663 EP - 667 SN - 0143-3334 AD - Rojanapo, W.: Biochemistry and Chemical Carcinogenesis Section, National Cancer Institute, Bangkok 10400, Thailand. N1 - Accession Number: 19931214388. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 50-29-3. Subject Subsets: Medical & Veterinary Mycology; Medical & Veterinary Entomology N2 - DDT markedly inhibited hepatocarcinogenesis in rats when administered at the same time as a dose of aflatoxin B1 (AFB1). Giving DDT to rats starting in the middle of AFB1 treatment (1 mg/rat over 8 wk) resulted in a significant enhancement of hepatocarcinogenesis. DDT exhibited a maximum tumour promoting effect when given either 1 or 3 wk after completion of AFB1 treatment, enhancing both the number of animals bearing liver carcinomas and the number of carcinomas per animal. Determination of γ-glutamyltranspeptidase in the serum revealed that the activity increased only in animals bearing big and/or a number of liver carcinomas, especially in those promoted by DDT. It is concluded that DDT acts as an inhibitor of AFB1-induced hepatocarcinogenesis if given prior to or at the same time as the carcinogen, but acts as a tumour promotor if given in the middle of or after the completion of AFB1 treatment. KW - Aflatoxins KW - carcinogenesis KW - DDT KW - effects KW - Laboratory animals KW - liver KW - Mycotoxins KW - Organochlorine insecticides KW - Pesticides KW - poisoning KW - susceptibility KW - toxicity KW - Toxicology KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dicophane KW - fungal toxins KW - toxicosis KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214388&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential effects of dietary β-carotene on papilloma and carcinoma formation induced by an initiation-promotion protocol in SENCAR mouse skin. AU - Chen, L. C. AU - Sly, L. AU - Jones, C. S. AU - Tarone, R. AU - Luca, L. M. de JO - Carcinogenesis JF - Carcinogenesis Y1 - 1993/// VL - 14 IS - 4 SP - 713 EP - 717 SN - 0143-3334 AD - Chen, L. C.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19941407380. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - Sencar mice were used to examine the effects of β-carotene on papilloma formation and the conversion of papillomas to carcinomas in a 2-stage protocol with one application of the initiator 7,12-dimethylbenz[a]anthracene (DMBA, 20 µg) and 20 weekly applications of the promoter 12-O-tetradecanoylphorbol-13-acetate (TPA, 2 µg). A purified vitamin A-free diet was supplemented with β-carotene at 4 concentrations (0.6, 6, 60 and 600 µg/g of diet) for female mice and 2 concentrations (60 and 600 µg/g) for male mice. Dietary supplementations of β-carotene did not result in significant changes in body weight and survival of female and male mice. However, papillomas developed more rapidly and papilloma incidence (percent of mice with papillomas) reached its maximum (100%) sooner in male mice fed on β-carotene 600 µg/g of diet than those fed on 60 µg/g. There were smaller differences in papilloma incidence among the dietary groups in female mice, but the papilloma incidence again reached 100% sooner in mice fed on 600 µg/g. Female and male mice fed on 600 µg had significantly higher papilloma yields (average number of papillomas/mouse) than other dietary groups and a very low percentage of these papillomas converted to carcinomas in these mice. Thus, β-carotene inhibited the conversion of papillomas to carcinomas in both sexes. In addition, papilloma yields were higher in female mice and these papillomas regressed more quickly than those in the corresponding groups of male mice. In conclusion, dietary β-carotene caused differential effects on papilloma formation in female and male SENCAR mice treated with DMBA and TPA in a 2-stage carcinogenesis protocol. KW - beta-carotene KW - carcinoma KW - intake KW - skin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dermis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407380&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduction in growth temperature minimizes instability of large plasmids containing HIV-1 proviral genomes. AU - Joshi, A. AU - Jeang, K. T. JO - BioTechniques JF - BioTechniques Y1 - 1993/// VL - 14 IS - 6 SP - 880 EP - 880, 884, 886 AD - Joshi, A.: Laboratory of Molecular Microbiology, Building 4, Room 306, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005907. Publication Type: Journal Article. Language: English. KW - genomes KW - human immunodeficiency viruses KW - Molecular biology KW - Plasmids KW - proviruses KW - Stability KW - Temperature KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cell culture technique KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005907&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Managing occupational exposures to HIV-1 in the healthcare workplace. AU - Fahey, B. J. AU - Beekmann, S. E. AU - Schmitt, J. M. AU - Fedio, J. M. AU - Henderson, D. K. JO - Infection Control and Hospital Epidemiology JF - Infection Control and Hospital Epidemiology Y1 - 1993/// VL - 14 IS - 7 SP - 405 EP - 412 SN - 0899-823X AD - Fahey, B. J.: (D.K. Henderson) Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C146, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005946. Publication Type: Journal Article. Language: English. KW - Health care workers KW - HIV infections KW - Occupational transmission KW - Psychosocial aspects KW - human immunodeficiency virus infections KW - Medical care KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Occupational Health and Safety (VV900) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005946&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn. AU - Ghoshal, A. AU - Snyderwine, E. G. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1993/// VL - 14 IS - 11 SP - 2199 EP - 2203 SN - 0143-3334 AD - Ghoshal, A.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethseda, MD 20892-0037, USA. N1 - Accession Number: 19940405483. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Dairy Science; Human Nutrition N2 - The distribution, DNA adduction and excretion into milk of potent multi-organ carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in lactating female F344 rats with 5-day-old pups. Six h after a single dose (10 mg/kg body wt per os) of radiolabelled IQ, MeIQx or PhIP, radioactivity in lactating dams was highest in the liver and kidney, followed by mammary glands, omental fat and brain tissue. By 24 h after carcinogen administration, all tissues of the dams had significantly reduced levels of radioactivity, except for omental fat which exhibited only a slight change in radioactivity levels between 6 and 24 h. 32P-postlabelling analysis showed that levels of DNA adducts in mammary gland 6 h after dosing were 2.2, 0.7 and 0.2 adducts/107 nucleotides for PhIP, IQ and MeIQx respectively. In contrast, in hepatic DNA, the levels of IQ-adducts (5.5 adducts/107 nucleotides) were 11 times higher than those of PhIP of MeIQx. The stomach contents, liver, kidney and urine of pups nursed by dams which had received radiolabelled IQ, MeIQx or PhIP were radioactive, indicating that these carcinogens (and/or their metabolites) had been excreted into milk and absorbed by the pups. After a 6-h suckling period, the amount of PhIP-derived radioactivity in the stomach contents of the pups was approximately 10 times higher than that seen with IQ or MeIQx. Urine from pups in the 3 groups was mutagenic in the Ames assay with Salmonella TA98 in the presence of an S9 activating system. IQ-, MeIQx- and PhIP-DNA adducts, at levels of 0.25-0.46 adducts/108 nucleotides, were detected in the livers of pups using the 32P-postlabelling method under intensification conditions. These results indicate that milk is a route of exposure of the newborn to heterocyclic amines. The presence of DNA adducts in the tissue of pups further suggests that this route may have a carcinogenic consequence to the newborn. KW - carcinogenesis KW - carcinogens KW - excretion KW - heterocyclic nitrogen compounds KW - intake KW - lactation KW - pups KW - rat milk KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - rat lactation KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940405483&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regressive and non-regressive thyroid lesions of the rat induced by single injection of N-bis(2-hydroxypropyl)nitrosamine and iodine deficient diet. AU - Kanno, J. AU - Maronpot, R. R. AU - Takahashi, M. AU - Kasuga, T. AU - Hayashi, Y. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1993/// VL - 14 IS - 11 SP - 2389 EP - 2396 SN - 0143-3334 AD - Kanno, J.: Laboratory of Experimental Pathology, Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19941411222. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition N2 - 6-week-old male F344 rats were divided into 4 groups. Rats in groups 1 (n = 16) and 3 (n = 14) received a subcutaneous injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN) (2800 mg/kg) in experimental week 1 while rats in groups 2 (n = 5) and 4 (n = 5) received saline. From weeks 2-20, all rats were given an iodine deficient (I-def) diet and tap water. Groups 1 and 2 were killed for the measurements of thyroid-stimulating hormone (TSH), thyroxine (T4), the maximum thyroid width (MTW), thyroid weight, morphology, morphometrics and proliferating cell nuclear antigen (PCNA) labelling index (LI). The thyroids of the rats in group 3 and 4 were surgically exposed and the MTW's were measured. These latter rats were given basal diet for 6 weeks to recover from I deficiency, and then killed for the same measurements. Thyroid nodular lesions in group 1 rats were classified into 5 categories (NL0, NL1, NL2 NL3 and NL4) based upon incremental cellular and structural atypia. 2 types of regressive nodules (NL′0 and NL′1+2) were identified in the recovered rats as the regressed form of NL0, NL1 and NL2 lesions. NL3 and NL4 nodules were seen in groups 1 and 3. The mean number of combined NL0, NL1 or NL2 lesions was 28.44±6.12 nodules per rat (NPR) in group 1 rats and the mean number of NL′0 and NL′1+2 lesions was 28.07±13.05 NPR in group 3 rats. The mean number of NL3 or NL4 lesions was 1.70 NPR in group 1 rats and 3.42 NPR in group 3 rats. The LIs were NL0 (6.4±2.5%), NL1 (7.7±4.4%), NL2 (0.7±0.3%), NL3 (7.5 ±1.3%) and NL4 (14.4±5.3%) in group 1 rats and NL′0 (<0.001%), NL′1+2 (<0.01%), NL3 (9.0±4.4%) and NL4 (23.3±17.8%) in group 3 rats. The thyroid weights of group 4 rats were 41% of group 2 rats. The volume fraction (VF) of the non-NL3, non-NL4 areas in group 3 rats was 40% of that in group 1 rats. However, the VF of NL3 or NL4 lesions in group 3 rats was 520% of that of group 1 rats. In summary, the growth of the NL0, NL1 and NL2 lesions was TSH-dependent, whereas NL3 and NL4 lesions were TSH-independent. In conclusion, affirmative morphological criteria were established to determine growth dependency on sustained serum TSH for thyroid nodular lesions induced in F344 rats by DHPN and I-def diet. KW - deficiency KW - iodine KW - lesions KW - nitrosamines KW - thyroid gland KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - thyroid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941411222&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adenocarcinomas of the uterine cervix: the epidemiology of an increasing problem. AU - Kruger Kjaer, S. AU - Brinton, L. A. JO - Epidemiologic Reviews JF - Epidemiologic Reviews Y1 - 1993/// VL - 15 IS - 2 SP - 486 EP - 498 SN - 0193-936X AD - Kruger Kjaer, S.: (L.A. Brinton) Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028134. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Subject Subsets: Public Health N2 - A review. KW - cervix KW - epidemiology KW - neoplasms KW - reviews KW - cancer sites KW - cancers KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028134&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The medicinal leech as a source of infection. AU - Fedorko, D. P. JO - Clinical Microbiology Newsletter JF - Clinical Microbiology Newsletter Y1 - 1993/// VL - 15 IS - 21 SP - 164 EP - 165 SN - 0196-4399 AD - Fedorko, D. P.: Clinical Pathology Department, Building 10, Room 2C-385, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942025103. Publication Type: Journal Article; Editorial; Journal article. Language: English. Number of References: 13 ref. Subject Subsets: Helminthology; Protozoology; Public Health N2 - A short overview. KW - disease transmission KW - human diseases KW - infectious diseases KW - parasites KW - reviews KW - transmission KW - Hirudo medicinalis KW - man KW - protozoa KW - Trypanosoma cruzi KW - Hirudo KW - Hirudidae KW - Hirudinea KW - Annelida KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - communicable diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025103&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association between Rochalimaea infection and cat-scratch disease. AU - Gradon, J. D. AU - Stein, D. S. AU - Schwartzmann, W. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1993/// VL - 17 IS - 2 SP - 287 EP - 288 SN - 1058-4838 AD - Gradon, J. D.: Medical Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. N1 - Accession Number: 19950503164. Publication Type: Journal Article. Language: English. Number of References: 4 ref. N2 - Reference is made to the article by W.A. Schwartzmann (1992) [Clinical Infectious Diseases, 15: 893-902] on R. henselae [Bartonella henselae] in the aetiology of cat-scratch disease. Dr Schwartzmann replies. KW - aetiology KW - human diseases KW - Bartonella henselae KW - man KW - Bartonella KW - Bartonellaceae KW - Rhizobiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - cat-scratch disease KW - causal agents KW - etiology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - MRI of choroidal plexus involvement in intracranial cryptococcosis. AU - Patronas, N. J. AU - Makariou, E. V. JO - Journal of Computer Assisted Tomography JF - Journal of Computer Assisted Tomography Y1 - 1993/// VL - 17 IS - 4 SP - 547 EP - 550 SN - 0363-8715 AD - Patronas, N. J.: Department of Radiology, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200843. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Two cases of central nervous system Cryptococcus neoformans infection are reported in 45- and 37-yr-old HIV-negative women from Maryland, USA. In both cases magnetic resonance imaging demonstrated the involvement of the ventricles and the choroid plexuses. The choroid plexuses were unusually enlarged and intensely enlarged. Intraventricular loculations were also noted including entrapment of cerebrospinal fluid in the temporal horns. Both patients recovered after treatment with amphotericin B and amphotericin B followed by fluconazole, respectively. KW - case reports KW - central nervous system KW - cryptococcosis KW - diagnosis KW - hosts KW - human diseases KW - infections KW - magnetic resonance imaging KW - Maryland KW - USA KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - CNS KW - european blastomycosis KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200843&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune-based therapeutics: scientific rationale and the promising approaches to the treatment of the human immunodeficiency virus-infected individual. AU - Stein, D. S. AU - Timpone, J. G. AU - Gradon, J. D. AU - Kagan, J. M. AU - Schnittman, S. M. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1993/// VL - 17 IS - 4 SP - 749 EP - 771 SN - 1058-4838 AD - Stein, D. S.: (S.M. Schnittman) Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Rockville, MD 20892, USA. N1 - Accession Number: 19932004636. Publication Type: Journal Article. Language: English. Number of References: 195 ref. KW - Cytokines KW - HIV infections KW - Immunomodulators KW - immunopathology KW - passive immunization KW - Treatment KW - Vaccines KW - Adoptive cellular immunotherapy KW - human immunodeficiency virus infections KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Host Resistance and Immunity (HH600) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004636&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new approach for estimating healthy body weights. AU - Garrison, R. J. AU - Kannel, W. B. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1993/// VL - 17 IS - 7 SP - 417 EP - 423 SN - 0307-0565 AD - Garrison, R. J.: Field Studies and Biometry Branch, Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19941404217. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition N2 - A strategy based on a more direct measure of adiposity, subscapular skinfolds and cardiovascular disease risk factors, rather than mortality for the estimation of body weight is discussed. This approach provides a means for estimating standards that are consistent with optimum cardiovascular health without the lengthy follow-up required for mortality studies. Data on 2447 non-smoking men and women, 20 to 59 years old is used. 7 cardiovascular disease risk factors were significantly related to subscapular skinfold thickness in both sexes in an unfavourable direction. Optimal subscapular skinfolds based on these risk factors for 20 to 39 year-olds were estimated to be <12 for men and 15 mm for women. Men and women who had subscapular skinfolds at or below the optimal level had a mean body mass index (BMI) of 22.6 and 21.1 kg/m², respectively. The probability of being above the optimum adiposity rises rapidly across BMI levels >20 kg/m² and plateaus at above 0.90 in both men and women with BMI >24 km/m². Thus, screening for above optimal adiposity is necessary only in individuals with BMI at or <24 kg/m². KW - anthropometric dimensions KW - assessment KW - body composition KW - body measurements KW - body weight KW - cardiovascular diseases KW - estimation KW - risk KW - standards KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anthropometric measurements KW - Laws and Regulations (DD500) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404217&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Decreased physical activity in Pima Indian compared with Caucasian children. AU - Fontvieille, A. M. AU - Kriska, A. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1993/// VL - 17 IS - 8 SP - 445 EP - 452 SN - 0307-0565 AD - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19941404220. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - The relation between physical activity and body composition was examined in 43 Pima Indians (22 boys, 21 girls; 9.9±1.1 years old) and 42 Caucasians (21 boys, 21 girls; 9.7±1.2 years old). A list of usual sport leisure activities was established (bicycling, swimming, basketball) and subjects were asked how much time they had devoted to each activity over the past week and the last year. Data on time spent playing outside (excluding sport leisure activities for estimation of physical activity) and watching television/videos were also collected. Pima Indians were taller (143±9 vs. 137±8 cm, P<0.001), heavier (48.6±15.8 vs. 32.9±7.8 kg, P<0.0001) and fatter (39±16 vs. 24±7% fat, P<0.001) than Caucasians. Pima Indian girls showed lower past year and past week sport leisure activity than Caucasian girls (P<0.01) and spent more time watching television/videos (P<0.05). Pima boys showed lower past week sport leisure activity than Caucasian boys (P<0.05). In Pima Indian boys, past year sport leisure activity correlated negatively (P<0.05) with body mass index (r = -0.49) and percentage body fat (r = -0.56). However, such correlations were not found in Pima Indian girls, possibly due to their very low levels of activity. Even though cause and effect cannot be distinguished in cross-sectional studies, findings suggest that decreased physical activity and increased television viewing may contribute to development of obesity in Pima Indian children. KW - American Indians KW - body composition KW - body fat KW - children KW - ethnic groups KW - obesity KW - physical activity KW - television KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404220&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy cost of arousal: effect of sex, race and obesity. AU - Fontvieille, A. M. AU - Ferraro, R. T. AU - Rising, R. AU - Larson, D. E. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1993/// VL - 17 IS - 12 SP - 705 EP - 709 SN - 0307-0565 AD - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. N1 - Accession Number: 19941408466. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - The basal (BMR) to sleeping metabolic rate (SMR) ratio might represent an estimate of the activation of the nervous system (central/sympathetic) from sleeping to basal state. 24-h energy expenditure (24EE), BMR and SMR were measured in a respiratory chamber in Caucasians (63 men/59 women 32±10 years old, 94±33 kg, 29±11% fat) and in Pima Indians (68 men/55 women 29±7 years old, 100±25 kg, 34±9% fat). The BMR/SMR ratio varied greatly between individuals (1.05±0.08; range 0.87 to 1.34). In Pima Indians, BMR/SMR was inversely correlated to both fat mass (r = -0.26; P<0.01) and BMI (r = -0.22; P<0.05), whereas, in Caucasians, BMR/SMR was inversely correlated to waist/thigh circumference ratio (r = -0.28; P<0.01). On average, the BMR/SMR was higher in Pima Indians than in Caucasians (1.06±0.08 vs. 1.03±0.07, P<0.01) and higher in Pima Indian men than in Pima Indian women (1.08±0.09 vs. 1.04±0.06, P<0.05). KW - body composition KW - energy exchange KW - energy metabolism KW - ethnic groups KW - metabolism KW - obesity KW - sex differences KW - sympathetic nervous system KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408466&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolic predictors of obesity: cross-sectional versus longitudinal data. AU - Ravussin, E. AU - Swinburn, B. A. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1993/// VL - 17 IS - SUP 3 SP - S28 EP - S31 SN - 0307-0565 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Suite 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19941404195. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - The effect of energy expenditure, spontaneous physical activity, respiratory quotient and insulin sensitivity on weight gain in the Pima Indians of Arizona, USA, are reviewed. KW - body composition KW - energy exchange KW - ethnic groups KW - insulin KW - metabolism KW - obesity KW - physical activity KW - respiratory quotient KW - reviews KW - weight gain KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - sensitivity KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404195&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevention of invasive fungal infections in patients with neoplastic diseases. AU - Walsh, T. J. AU - Lee, J. W. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1993/// VL - 17 IS - Suppl. 2 SP - S468 EP - S480 SN - 1058-4838 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941202079. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 124 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - Strategies for the prevention of invasive mycoses in granulocytopenic and other immunocompromised patients with neoplastic diseases are reviewed. Defining strategies are discussed for prevention of invasive Candida infections with imidazoles, triazoles, orally administered polyenes and intravenously and empirically administered amphotericin B, and for invasive Aspergillus infections with triazoles, intranasal amphotericin B, low-dose amphotericin B, secondary prophylaxis and environmental measures. Problems in utilizing antifungal chemoprophylaxis, including selection of patients for antifungal prophylaxis, duration of treatment, drug interactions, techniques for early diagnosis and the emergence of resistant fungi, and future directions of antifungal therapy such as new antifungal agents and the use of recombinant human cytokines and peripheral stem cells are also considered. KW - amphotericin B KW - antifungal agents KW - aspergillosis KW - candidosis KW - drug therapy KW - human diseases KW - imidazoles KW - immunocompromised hosts KW - infections KW - neoplasms KW - opportunistic infections KW - predisposition KW - prophylaxis KW - triazoles KW - Aspergillus KW - Candida KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - cancers KW - candidiasis KW - chemotherapy KW - Controversies in the management of infections in immunocompromised patients KW - fungistats KW - fungus KW - Hyphomycetes KW - polyenes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941202079&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma. AU - Hoar Zahm, S. AU - Weisenburger, D. D. AU - Cantor, K. P. AU - Holmes, F. F. AU - Blair, A. JO - Scandinavian Journal of Work, Environment & Health JF - Scandinavian Journal of Work, Environment & Health Y1 - 1993/// VL - 19 IS - 2 SP - 108 EP - 114 SN - 0355-3140 AD - Hoar Zahm, S.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA. N1 - Accession Number: 19942026228. Publication Type: Journal Article. Language: English. Registry Number: 1912-24-9. Subject Subsets: Public Health N2 - Atrazine is the most commonly used herbicide in the United States and is a wide-spread groundwater contaminant in the Midwest. The role of atrazine in the development of human non-Hodgkin's lymphoma (NHL) was investigated in three case-referent studies conducted in four midwestern states in the United States. A total of 993 white men with NHL and 2918 population-based referents were interviewed concerning their agricultural practices. When the results of the three studies were combined, atrazine use was associated with an odds ratio of 1.4 [95% confidence interval (95% CI) 1.1-1.8, 130 cases, 249 referents] for NHL. However, adjustments for the use of 2,4-dichlorophenoxyacetic acid and organophosphate insecticides reduced the apparent association between NHL and atrazine in all but one state and reduced the associations for the long-term and frequent users in Nebraska. Detailed analyses suggested that there was little or no increase in the risk of NHL attributable to the agricultural use of atrazine.AS/R.D. Verschoyle KW - atrazine KW - exposure KW - herbicides KW - Non-Hodgkin's lymphoma KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - United States of America KW - weedicides KW - weedkillers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A comparison of diets of blacks and whites in three areas of the United States. AU - Swanson, C. A. AU - Gridley, G. AU - Greenberg, R. S. AU - Schoenberg, J. B. AU - Swanson, G. M. AU - Brown, L. M. AU - Hayes, R. AU - Silverman, D. AU - Pottern, L. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1993/// VL - 20 IS - 2 SP - 153 EP - 165 SN - 0163-5581 AD - Swanson, C. A.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413211. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Dietary factors may contribute to the increased cancer risk of blacks. As a first step to explore this hypothesis, we examined food frequency data obtained by interview with 1976 adults (881 blacks and 1095 whites) randomly selected from three areas (New Jersey, Detroit, Atlanta) of the United States. The a priori hypothesis was that blacks were more likely to consume diets low in fruits and vegetables and/or high in fat, particularly saturated fat. Contrary to expectation, blacks were more frequent consumers of fruits and vegetables considered to be protective against cancer (citrus fruits, cruciferous vegetables, and vegetables rich in vitamins A and C). Intake of both total and saturated fat was slightly lower among blacks than whites. This analysis does not rule out a role for these dietary factors in the aetiology of cancer but indicates that ascribing the excess cancer risk among blacks to their frequency of fruit and vegetable consumption or intake of fat per se is inadequate. This suggests that alternative dietary explanations for the racial disparity in cancer risk should be pursued in future studies. KW - aetiology KW - blacks KW - Caucasian KW - citrus fruits KW - consumers KW - diet studies KW - diets KW - ethnic groups KW - ethnicity KW - fruits KW - intake KW - neoplasms KW - protection KW - questionnaires KW - retinol KW - risk factors KW - saturated fats KW - vegetables KW - vitamins KW - USA KW - Brassicaceae KW - Citrus KW - man KW - Capparidales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Rutaceae KW - Sapindales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - Capparales KW - causal agents KW - ethnic differences KW - etiology KW - Rutales KW - United States of America KW - vegetable crops KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413211&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors and survival from breast cancer. AU - Rohan, T. E. AU - Hiller, J. E. AU - McMichael, A. J. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1993/// VL - 20 IS - 2 SP - 167 EP - 177 SN - 0163-5581 AD - Rohan, T. E.: National Cancer Institute of Canada (NCIC) Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. N1 - Accession Number: 20001413212. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 50-81-7, 7235-40-7. Subject Subsets: Human Nutrition N2 - The association between self-reported intake of various dietary factors at diagnosis and survival from breast cancer was studied in a population-based cohort of breast cancer patients in Adelaide, South Australia. These patients had been recruited between 1982 and 1984 into a case-control study of diet and incident breast cancer. Of the 451 patients recruited originally, 412 were followed for a median interval of 5.5 years. There were decreases in the risk of death from breast cancer ranging from 25 to 40% at all levels of energy and protein intake above the baseline, whereas for fat intake there was a 40% increase in risk at the uppermost quintile level. There was also some reduction in risk at the upper levels of intake of β-carotene and vitamin C. However, there were no dose-dependent variations in risk of death by level of intake for any of the dietary factors studied, and most of the variation in risk that was observed was relatively insubstantial. KW - ascorbic acid KW - beta-carotene KW - breast cancer KW - diagnosis KW - diet studies KW - diets KW - energy consumption KW - intake KW - mammary glands KW - mortality KW - neoplasms KW - protein intake KW - risk factors KW - variation KW - women KW - Australia KW - South Australia KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - Australia KW - cancers KW - death rate KW - energy use KW - energy utilization KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A Borrelia burgdorferi homolog of the Escherichia coli rho gene. AU - Tilly, K. AU - Campbell, J. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1993/// VL - 21 IS - 4 SP - 1040 EP - 1040 SN - 0305-1048 AD - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950502652. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology KW - genes KW - molecular genetics KW - nucleotide sequences KW - Borrelia burgdorferi KW - Escherichia coli KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - bacterium KW - biochemical genetics KW - DNA sequences KW - E. coli KW - gene homologue KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502652&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fidelity of DNA synthesis catalyzed by human DNA polymerase α and HIV-1 reverse transcriptase: effect of reaction pH. AU - Eckert, K. A. AU - Kunkel, T. A. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1993/// VL - 21 IS - 22 SP - 5212 EP - 5220 SN - 0305-1048 AD - Eckert, K. A.: (T.A. Kunkel) National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19942025762. Publication Type: Journal Article. Language: English. Registry Number: 9012-90-2. KW - Biochemistry KW - DNA polymerase KW - Gene expression KW - human immunodeficiency viruses KW - Molecular biology KW - PH KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Error rate KW - Fidelity KW - HUMAN IMMUNODEFICIENCY VIRUS KW - hydrogen ion concentration KW - potential of hydrogen KW - Reverse transcriptase activity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025762&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Physical activity and occupational risk of colon cancer in Shanghai, China. AU - Chow, W. H. AU - Dosemeci, M. AU - et al. AU - Zheng, W. ( JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1993/// VL - 22 IS - 1 SP - 23 EP - 29 SN - 0300-5771 AD - Chow, W. H.: National Cancer Institute, 6130 Executive Blvd., EPN 415, Rockville, MD 20892, USA. N1 - Accession Number: 19932020376. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Using occupational data for over 2000 colon cancer cases diagnosed between 1980 and 1984 in Shanghai, and employment information from the 1982 census for the Shanghai population, standardized incidence ratios (SIR) were computed for occupational groups classified by job types and physical activity levels. Men employed in occupations with low physical activity levels had modest but significantly elevated risks of colon cancer. SIR for jobs with low activity based on sitting time was 121 (95% confidence interval, CI: 108-135) and based on energy expenditure was 126 (95% CI: 115-138). Corresponding SIR for women were 99 (95% CI: 83-118) and 113 (95% CI: 100-127). The data were also used to screen for specific occupations with elevated SIR to generate leads to occupational colon cancer. Increased incidence was observed for professional and other white collar workers, and male chemical processors and female textile workers. The findings add to the emerging evidence that workplace activity may influence the risk of this common cancer.AS KW - colon KW - neoplasms KW - occupational hazards KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020376&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Community-based intervention: the coronary risk factor study (CORIS). AU - Rossouw, J. E. AU - Jooste, P. L. AU - et al. AU - Chalton, D. O. ( JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1993/// VL - 22 IS - 3 SP - 428 EP - 438 SN - 0300-5771 AD - Rossouw, J. E.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022603. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - The Coronary Risk Factor Study (CORIS) examined the feasibility and effectiveness of a multifactorial community intervention programme to reduce coronary heart disease (CHD) risk factor levels. Three Afrikaner communities were surveyed before and after a 4-year intervention in two of the communities, the third serving as a control (C). Intervention was primarily by small mass media (low-intensity intervention, LII) or by small mass media plus interpersonal intervention to high-risk individuals (high-intensity intervention, HII). After allowing for change in C, significant net reductions in blood pressure, smoking, and risk score were obtained in LII and HII alike. Though the total cholesterol (TC) fell by 10-12%, there was no net reduction in favour of the intervention communities. However, LII and HII resulted in significant increases in high-density lipoprotein cholesterol (HDL-C) levels and HDL-C/TC ratios in comparison to C. Overall, the LII community fared almost as well as the HII community, and high-risk individuals did not show a greater change in risk factors than others. [The authors] conclude that community-based intervention works, and that in these particular communities a media-based health education programme was more cost-effective than one which adds a greater degree of interpersonal intervention.AS KW - heart diseases KW - intervention KW - myocardial ischaemia KW - Africa KW - South Africa KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - Southern Africa KW - Africa South of Sahara KW - Threshold Countries KW - coronary diseases KW - ischaemic heart disease KW - myocardial ischemia KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022603&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Youth tobacco use in the United States-problem, progress, goals, and potential solutions. AU - Glynn, T. J. AU - Greenwald, P. AU - Mills, S. M. AU - Manley, M. W. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1993/// VL - 22 IS - 4 SP - 568 EP - 575 SN - 0091-7435 AD - Glynn, T. J.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 243, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19942023912. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - adolescents KW - children KW - Tobacco smoking KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - teenagers KW - United States of America KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942023912&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The design and analysis of cholera vaccine trials: recent lessons from Bangladesh. AU - Clemens, J. AU - Sack, D. AU - et al. AU - Rao, M. ( JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1993/// VL - 22 IS - 4 SP - 724 EP - 730 SN - 0300-5771 AD - Clemens, J.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, G100 Executive Blvd., Bethesda, MD 20892, USA. N1 - Accession Number: 19932023301. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - The recent spread of cholera to Latin America, together with the persistent burden of this disease in Asia and Africa, have stimulated efforts to evaluate new cholera vaccines in field settings. Although the standard experimental paradigm for vaccine field trials is well established, the success of these trials will also depend on suitable consideration of the epidemiology of cholera and of cholera vaccination in the settings under study. Epidemiological studies done in Bangladesh emphasize the importance of appreciating the poorly predictable, multifocal occurrence of cholera in estimating a probable incidence of cholera for a field trial. They also underscore how the filtering effect of enrolling subjects into a prospective trial can dramatically reduce the available population for study, and can yield a study sample whose expected risk of cholera differs markedly from that for the source population. Finally, the data highlight the subtle effects that the mode of surveillance and the choice of an outcome definition can have upon protective efficacy, and emphasize the need for subgroup analyses that address the distinctive variations in vaccine protection that may occur in subjects differing in age and in ABO blood groups, and in subjects exposed to classical versus El Tor cholera. [There is no mention of the known serotype-specificity of immunity to cholera-which demands that cholera vaccine produce a balanced response to the Inaba and Ogawa serotypes. Also, because the paper was written before reports of the epidemic and pandemic potential of a third (Bengal) serotype of cholera vibrio, the need for this third component in future cholera vaccines is not recognized.] N.W. Preston KW - Cholera KW - inactivated vaccines KW - trials KW - Asia KW - Bangladesh KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - South Asia KW - Asia KW - killed vaccines KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023301&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer mortality among jewelry workers. AU - Hayes, R. B. AU - Dosemeci, M. AU - Riscigno, M. AU - Blair, A. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1993/// VL - 24 IS - 6 SP - 743 EP - 751 SN - 0271-3586 AD - Hayes, R. B.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19942027646. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The mortality of 1009 male members of a New York, USA, jewellery workers union was investigated for the period 1950-1980, and for the years 1984-1989 among 919 men and 605 women, from 24 states in the USA, identified as jewellery workers on death certificates. "This study suggests that workers in the jewellery industry may be at excess risk for malignancies of the digestive system. Excesses were noted for oesophageal cancer in 24 states, due largely to an excess among Rhode Island jewellery workers. Stomach cancer mortality was strikingly in excess for women in the jewellery industry in 24 states. Colon cancer excesses were identified for jewellery workers in New York and in the 24 states. Further analysis of colon cancer indicated that the excesses identified in the 24 states were due to increased proportional mortality in 23 states, excluding Rhode Island. Valerie A. Pritchard KW - mortality KW - neoplasms KW - occupational health KW - Occupations KW - workers KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - death rate KW - jewellers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027646&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer among migrant and seasonal farmworkers: an epidemiologic review and research agenda. AU - Zahm, S. H. AU - Blair, A. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1993/// VL - 24 IS - 6 SP - 753 EP - 766 SN - 0271-3586 AD - Zahm, S. H.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA. N1 - Accession Number: 19942027619. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Public Health KW - agriculture KW - farm workers KW - migrants KW - neoplasms KW - occupational health KW - Occupations KW - reviews KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027619&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Opportunistic infections: treatment and developmental therapeutics of cryptosporidiosis and isosporiasis. AU - Georgiev, V. S. JO - Drug Development Research JF - Drug Development Research Y1 - 1993/// VL - 28 IS - 4 SP - 445 EP - 459 SN - 0272-4391 AD - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4C-39, Bethesda, MD 20892, USA. N1 - Accession Number: 19950806050. Publication Type: Journal Article. Language: English. Number of References: 203 ref. Subject Subsets: Protozoology N2 - This review critically examines cryptosporidiosis and isosporiasis. Although associated with many animal species, Cryptosporidium spp. and Isospora belli are also pathogenic in man. In immunocompetent hosts, the infections are usually self-limited, flu-like gastrointestinal disorders which resolve spontaneously. However, in immunocompromised hosts, cryptosporidiosis is a severe, debilitating, and prolonged illness, with high morbidity and no known effective therapy against it. Immunotherapy is being actively pursued as one potentially useful approach for the treatment of cryptosporidiosis. Azithromycin, a new macrolide antibiotic, has also shown promise in preclinical studies. In the case of isosporiasis, the combination of trimethoprim and sulfamethoxazole has been found to be effective, although HIV patients have shown a high rate of relapse and, therefore, the need for suppressive maintenance therapy. KW - acquired immune deficiency syndrome KW - cryptosporidiosis KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunotherapy KW - isosporiasis KW - opportunistic infections KW - parasites KW - reviews KW - Cryptosporidium KW - Isospora belli KW - man KW - protozoa KW - Cryptosporidiidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Isospora KW - Eimeriidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - AIDS KW - chemotherapy KW - general account KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806050&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does diet provide adequate amounts of calcium, iron, magnesium, and zinc in a well-educated adult population? AU - Hallfrisch, J. AU - Muller, D. C. JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1993/// VL - 28 IS - 4/5 SP - 473 EP - 483 SN - 0531-5565 AD - Hallfrisch, J.: Metabolism Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19951412371. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-95-4, 7440-66-6. Subject Subsets: Human Nutrition N2 - Standard advice from dietitians, nutritionists, and physicians is that if one eats a well-balanced diet containing a variety of foods, supplements are not necessary. Little information is available, especially in those over 75 years old, to determine whether actual diets do provide adequate amounts of these minerals. The participants of the Baltimore Longitudinal Study of Aging, USA provide 7-day records which include vitamin and mineral supplement intakes. Median daily dietary intakes from diet in all 564 subjects and from diet plus supplements in those who use them were analyzed by age group and gender. More women than men took supplements. Median intakes of calcium from diet were below the recommended dietary allowance (RDA) for unsupplemented women and for supplemented women over 60. Approximately 25% of women under 50 and 10% of women over 50 consumed less than two thirds of the RDA for iron from diet. For both men and women, all groups had median diet intakes below the RDA for magnesium. 40% of men and about half of women consumed less than two thirds of the RDA. These results indicate that many people in this well-educated, presumably well-nourished population did not consume adequate amounts of calcium, iron, magnesium, and zinc from diet. More women than men are at risk. Even those taking supplements did not consume adequate levels of some minerals. KW - aging KW - calcium KW - diet studies KW - iron KW - magnesium KW - mineral supplements KW - minerals KW - old age KW - requirements KW - supplements KW - trace elements KW - zinc KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ageing KW - microelements KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Is there any relationship between aluminum and Alzheimer's disease? AU - Eichhorn, G. L. JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1993/// VL - 28 IS - 4/5 SP - 493 EP - 498 SN - 0531-5565 AD - Eichhorn, G. L.: National Institutes of Health, National Institute on Aging, Laboratory of Cellular and Molecular Biology, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19951412372. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 7429-90-5. Subject Subsets: Human Nutrition N2 - The role of aluminum in Alzheimer's disease (AD) is reviewed. While current data would suggest the lack of a causative role, alterations in the brain and other organ systems caused by AD might increase the penetration of aluminum as well as other metals into the brain and lead to their contribution to such pathological features as neurofibrillar tangles. KW - aluminium KW - Alzheimer's disease KW - brain KW - reviews KW - trace elements KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - aluminum KW - cerebrum KW - microelements KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412372&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sex ratio and phoretic mites of fleas (Siphonaptera: Pulicidae and Hystrichopsyllidae) on the Nile grass rat (Arvicanthis niloticus) in Kenya. AU - Schwan, T. G. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1993/// VL - 30 IS - 1 SP - 122 EP - 135 SN - 0022-2585 AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515210. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The sex ratio of fleas and their phoretic mites associated with A. niloticus were studied during 14 months in a grassland community of Lake Nakuru National Park, Kenya. Females of the fleas Dinopsyllus lypusus, Ctenophthalmus calceatus cabrius and Xenopsylla cheopis bantorum infested more grass rats and in greater numbers than did males. Phoretic hypopi (heteromorphic deutonymphs) of 2 species of mites, Psylloglyphus uilenbergi and Paraceroglyphus xenopsylla, varied seasonally in their abundance on fleas and utilized female fleas over male fleas for their major source of transport. Additionally, the mites were very host specific with nearly 100% of those identified on D. lypusus and C. calceatus cabrius being Psylloglyphus uilenbergi and 89% of the mites identified on X. cheopis bantorum being Paraceroglyphus xenopsylla. This level of specificity suggests that these mite-flea associations are highly evolved. The importance of female fleas as hosts for transporting mites also suggests that female-biased sex ratios of fleas on their hosts may be caused, in part, by females being more important as dispersers within flea populations. KW - Ecology KW - Ectoparasites KW - Hosts KW - phoresy KW - Population ecology KW - Seasonality KW - Sex ratio KW - Small mammals KW - Wild animals KW - Africa KW - Kenya KW - Acari KW - Acaridae KW - Arachnida KW - Arvicanthis niloticus KW - Dinopsyllus KW - Dinopsyllus lypusus KW - Hystrichopsyllidae KW - Muridae KW - Pulicidae KW - Rodents KW - Siphonaptera KW - WINTERSCHMIDTIIDAE KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Astigmata KW - mites KW - Acari KW - Arvicanthis KW - Murinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Siphonaptera KW - insects KW - Hexapoda KW - Ctenophthalmus KW - Hystrichopsyllidae KW - Dinopsyllus KW - Acaridae KW - Winterschmidtiidae KW - Xenopsylla cheopis KW - Xenopsylla KW - Pulicidae KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - East Africa KW - Africa South of Sahara KW - Ctenophthalmus calceatus KW - Ctenophthalmus calceatus cabrius KW - Paraceroglyphus KW - Paraceroglyphus xenopsylla KW - Psylloglyphus KW - Psylloglyphus uilenbergi KW - Saproglyphidae KW - Xenopsylla cheopis bantorum KW - Biological Resources (Animal) (PP710) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Reproduction and Development (LL210) (Discontinued March 2000) KW - Animal Behaviour (LL300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515210&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of Yersinia pestis infection on temperature preference and movement of the Oriental rat flea (Xenopsylla cheopis) (Siphonaptera: Pulicidae). AU - Thomas, R. E. AU - Karstens, R. H. AU - Schwan, T. G. JO - Journal of Medical Entomology JF - Journal of Medical Entomology Y1 - 1993/// VL - 30 IS - 1 SP - 209 EP - 213 SN - 0022-2585 AD - Thomas, R. E.: Laboratory of Vectors and Pathogens, Arthropod-Borne Infectious Diseases Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19930515219. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Previous laboratory studies have shown that inoculation of bacterial endotoxin into the haemocoel of some arthropods, or natural infection by a number of pathogens, causes them to seek out a higher ambient temperature. This phenomenon has been called 'behavioural fever'. Y. pestis is an endotoxin-producing bacterium that relies on infection of fleas for transmission. Behavioural fever in fleas might enhance the transmission of plague if infected fleas were induced to seek out a warm-bodied host after the death of an infected host. Studies indicate that in thermal gradients Y. pestis-infected fleas (X. cheopis) do not exhibit behavioural fever and in one experiment sought out a significantly lower temperature. KW - Disease vectors KW - Infections KW - Temperature KW - Enterobacteriaceae KW - Pulicidae KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Siphonaptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Xenopsylla KW - Pulicidae KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - bacterium KW - behavioural fever KW - Oriental rat flea KW - YERSINIA PSEUDOTUBERCULOSIS SUBSP. PESTIS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515219&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New method for plague surveillance using polymerase chain reaction to detect Yersinia pestis in fleas. AU - Hinnebusch, J. AU - Schwan, T. H. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1993/// VL - 31 IS - 6 SP - 1511 EP - 1514 SN - 0095-1137 AD - Hinnebusch, J.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19940500812. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases N2 - Yersinia pestis, the plague bacillus, infects a variety of mammals throughout the world and is transmitted by fleas. A polymerase chain reaction (PCR) test was developed using primers designed from the Y. pestis plasminogen activator gene to directly detect plague-infected fleas. As few as 10 Y. pestis cells were detected, even in the presence of flea tissue, by PCR and then agarose gel electrophoresis and ethidium bromide staining. The feasibility of the assay was demonstrated by using naturally infected Xenopsylla cheopis. The detection of Y. pestis in fleas by PCR provides a rapid and sensitive way to monitor plague in wild animal populations, allowing public health officials to better assess the potential risk of transmission to humans.From AS<new para>ADDITIONAL ABSTRACT:<new para>Yersinia pestis, the plague bacillus, infects a variety of mammals throughout the world and is transmitted by fleas. A polymerase chain reaction (PCR) test was developed using primers designed from the Y. pestis plasminogen activator gene to directly detect plague-infected fleas. As few as 10 Y. pestis cells were detected, even in the presence of flea tissue, by PCR and then agarose gel electrophoresis and ethidium bromide staining. The feasibility of the assay was demonstrated by using naturally infected Xenopsylla cheopis. The detection of Y. pestis in fleas by PCR provides a rapid and sensitive way to monitor plague in wild animal populations, allowing public health officials to better assess the potential risk of transmission to humans. KW - Detection KW - diagnostic techniques KW - disease vectors KW - Polymerase chain reaction KW - Enterobacteriaceae KW - Pulicidae KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Siphonaptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Xenopsylla KW - Pulicidae KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - bacterium KW - Oriental rat flea KW - PCR KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reactogenicity and immunogenicity of a high-titer rhesus rotavirus-based quadrivalent rotavirus vaccine. AU - Flores, J. AU - Perez-Schael, I. AU - Blanco, M. AU - Rojas, A. M. AU - Alfonzo, E. AU - Crespo, I. AU - Cunto, W. AU - Pittman, A. L. AU - Kapikian, A. Z. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1993/// VL - 31 IS - 9 SP - 2439 EP - 2445 SN - 0095-1137 AD - Flores, J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004092. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - The authors evaluated the reactogenicity and antigenicity of a quadrivalent rotavirus vaccine composed of serotype 3 rhesus rotavirus (RRV) and three single-gene-substitution reassortants of RRV and human strain D (D × RRV, serotype 1), DS1 (DS1 × RRV, serotype 2), or ST3 (ST3 × RRV, serotype 4) in a double-masked study with 302 infants in Caracas, Venezuela. Three doses of the quadrivalent vaccine composed of either 105 PFU (low titre) or 106 PFU (high titre) of each component were administered to 99 and 101 infants, respectively, at 4-week intervals starting at the second month of age; 102 infants received a placebo. Postvaccination reactions were monitored by home visits every other day during the week postvaccination. The vaccine was associated with the occurrence of mild, short-lived febrile episodes in 26% and 23% of the recipients after the first doses of high- or low-titre vaccine, respectively, in comparison with 13% of the infants receiving the placebo. Febrile reactions occurred less frequently in vaccinees after the second or third dose than after the initial dose. The vaccine was not significantly associated with diarrhoea or any additional symptom or sign. Serum specimens obtained shortly before the first, 4 weeks after the first, and 4 weeks after the third dose of vaccine or placebo were tested by an immunoglobulin A enzyme-linked immunosorbent assay and by neutralization assays. Seroresponses occurred significantly more often after 3 doses than after a single dose of vaccine or placebo were tested by an immunoglobulin A enzyme-linked immunosorbent assay and by neutralization assays. Seroresponses occurred significantly more often after 3 doses than after a single dose of either vaccine. Immunoglobulin A responses were observed in 80% and 79% of the infants after 3 doses of high- or low-titre vaccine, respectively. Most of the infants tested developed a neutralization response to RRV after 3 doses of the high-(90%) or low-(88%) titre vaccine. Neutralization response rates to human rotavirus serotypes 1 to 4 after 3 doses were similar in both vaccine groups and ranged from 33% to 53%. Overall, 93 of 97 infants receiving the low-titre vaccine and 87 of 90 receiving the high-titre vaccine developed seroresponses, as detected by any of the assays employed. The study indicates that 3 doses of quadrivalent vaccine at a titre of 106 PFU of each component offered no advantage over the lower-titre preparation for use in efficacy trials. KW - children KW - human diseases KW - immunization KW - infections KW - polyvalent vaccines KW - South America KW - Venezuela KW - man KW - rotavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - America KW - Andean Group KW - Developing Countries KW - Latin America KW - South America KW - Threshold Countries KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004092&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a protein in several Borrelia species which is related to OspC of the Lyme disease spirochetes. AU - Marconi, R. T. AU - Samuels, D. C. AU - Schwan, T. G. AU - Garon, C. F. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1993/// VL - 31 IS - 10 SP - 2577 EP - 2583 SN - 0095-1137 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19940500833. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science N2 - Using oligonucleotide probes which have previously been shown to be specific for the ospC gene found in the Lyme disease spirochaete species B. burgdorferi, B. garinii and group VS461 [B. afzelii], an ospC homologue was detected in other Borrelia species including B. coriaceae, B. hermsii, B. anserina, B. turicatae and B. parkeri was detected. In contrast to the Lyme disease spirochaetes, which carry the ospC gene on a 26-kb circular plasmid, the gene in other Borrelia species was mapped to linear plasmids which varied in size among the isolates tested. Some isolates carry multiple copies of the gene residing on linear plasmids of different sizes. The analyses conducted also demonstrate that these Borrelia species contain a linear chromosome. Northern (RNA) blot analyses demonstrated that the gene is transcriptionally expressed in all species examined. High levels of transcriptional expression were observed in some B. hermsii isolates. Transcriptional start site analyses revealed that the length of the untranslated leader sequence was identical to that observed in the Lyme disease spirochaete species. By Western blotting (immunoblotting) with antiserum (polyclonal) raised against the OspC protein of B. burgdorferi, an immunoreactive protein of the same molecular weight as the OspC found in Lyme disease spirochaete species was detected. The results presented demonstrate the presence of a protein that is genetically and antigenically related to OspC which is expressed in all species of the genus Borrelia tested. KW - antigens KW - bacterial diseases KW - chromosomes KW - gene mapping KW - genes KW - immunoblotting KW - molecular genetics KW - plasmids KW - proteins KW - Borrelia KW - Borrelia anserina KW - Borrelia burgdorferi KW - Borrelia coriaceae KW - Borrelia garinii KW - Borrelia hermsii KW - Borrelia parkeri KW - Borrelia turicatae KW - Spirochaetaceae KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - antigenicity KW - bacterial infections KW - bacterioses KW - bacterium KW - biochemical genetics KW - immunogens KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500833&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of microsporidian spores in clinical samples by indirect fluorescent-antibody assay using whole-cell antisera to Encephalitozoon cuniculi and Encephalitozoon hellem. AU - Zierdt, C. H. AU - Gill, V. J. AU - Zierdt, W. S. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1993/// VL - 31 IS - 11 SP - 3071 EP - 3074 SN - 0095-1137 AD - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950807961. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Protozoology N2 - Three polyclonal mouse antisera (to Encephalitozoon cuniculi, Nosema algerae and N. corneum) and 2 polyclonal rabbit antisera (to E. cuniculi and E. hellem) were used in an indirect immunofluorescence assay (IFA) with E. bieneusi, E. cuniculi and E. hellem spores. Antisera to E. cuniculi and E. hellem reacted strongly and equally with each other's spores. E. bieneusi was easily identified in duodenal and colonic biopsies, duodenal and colonic fluids, and faeces of symptomatic acquired immune deficiency syndrome (AIDS) patients by IFA. In a study of 12 AIDS patients with diarrhoea, the IFA identified Microspora in all of 11 faecal samples, 3 colon fluid samples, 6 duodenal fluid samples and 3 duodenal biopsy samples examined. Although the faecal sample of one patient was negative, the duodenal fluid was positive for microsporan spores by IFA. KW - acquired immune deficiency syndrome KW - biopsy KW - colon KW - cross reaction KW - diarrhoea KW - duodenum KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunodiagnosis KW - immunofluorescence KW - intestinal diseases KW - microsporidiosis KW - opportunistic infections KW - parasites KW - patients KW - spores KW - Encephalitozoon cuniculi KW - Encephalitozoon hellem KW - man KW - protozoa KW - Encephalitozoon KW - Encephalitozoonidae KW - Microspora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - AIDS KW - diarrhea KW - Encephalitozoon bieneusi KW - enteropathy KW - fluorescent antibody technique KW - human immunodeficiency virus KW - IFAT KW - scouring KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807961&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Distribution and molecular analysis of Lyme disease spirochetes, Borrelia burgdorferi, isolated from ticks throughout California. AU - Schwan, T. G. AU - Schrumpf, M. E. AU - Karstens, R. H. AU - Clover, J. R. AU - Wong, J. AU - Daugherty, M. AU - Struthers, M. AU - Rosa, P. A. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1993/// VL - 31 IS - 12 SP - 3096 EP - 3108 SN - 0095-1137 AD - Schwan, T. G.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19940500838. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Previous studies describing the occurrence and molecular characteristics of B. burgdorferi from California, USA, have been restricted primarily to isolates obtained from the north coastal region of this large and ecologically diverse state. The objective of this study was to look for and examine B. burgdorferi organisms isolated from Ixodes pacificus ticks collected from numerous regions spanning most parts of California where this tick is found. 31 isolates of B. burgdorferi were examined from individual or pooled I. pacificus ticks collected from 25 countries throughout the state. One isolate was obtained from ticks collected at Wawona Campground in Yosemite National Park, documenting the occurrence of the Lyme disease spirochaete in an area of intensive human recreational use. One isolate from an I. neotomae tick from an additional county (Mendocino) was also examined. SDS-PAGE, immunoblot analysis, agarose gel electrophoresis, Southern blot analysis and the polymerase chain reaction were used to examine the molecular and genetic determinants of these uncloned, low-passage-number isolates. All of the isolates were identified as B. burgdorferi by their protein profiles and reactivities with monoclonal and polyclonal antibodies, and all the isolates were typed by the polymerase chain reaction as North American-type spirochaetes (B. burgdorferi s.s.). Although products of the ospAB locus were identified in protein analysis in all of the isolates, several isolates contained deleted forms of this locus that would result in the expression of chimaeric OspA-OspB proteins. The analysis of OspC demonstrated that this protein was widely conserved among the isolates but was also quite variable in its molecular mass and the amount of it that was expressed. KW - antigens KW - disease vectors KW - DNA KW - epidemiology KW - immunoblotting KW - Lyme disease KW - molecular genetics KW - national parks KW - polymerase chain reaction KW - proteins KW - SDS-PAGE KW - California KW - North America KW - USA KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodes KW - Ixodes pacificus KW - Ixodidae KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodidae KW - Metastigmata KW - Acari KW - Ixodes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - immunogens KW - Ixodes neotomae KW - Ixodes spinipalpis KW - lyme borreliosis KW - PCR KW - sodium dodecyl sulfate-PAGE KW - United States of America KW - Land Resources (PP300) KW - Techniques and Methodology (ZZ900) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500838&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ocular infections in the acquired immunodeficiency syndrome. AU - Dugel, P. U. AU - Rao, N. A. JO - International Ophthalmology Clinics JF - International Ophthalmology Clinics Y1 - 1993/// VL - 33 IS - 1 SP - 103 EP - 127 SN - 0020-8167 AD - Dugel, P. U.: National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19942024237. Publication Type: Journal Article. Language: English. Number of References: 99 ref. Subject Subsets: Public Health N2 - The authors review posterior segment infections (of the retina, optic nerve and choroid mainly due to cytomegalovirus, Cryptococcus neoformans and Pneumocystis carinii) and anterior segment manifestations (including Kaposi's sarcoma, molluscum contagiosum, herpes zoster, keratitis and conjunctival conditions)D.W. FitzSimons KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Clinical aspects KW - Cryptococcosis KW - eye diseases KW - HIV infections KW - infections KW - Kaposi's sarcoma KW - mycoses KW - Neoplasms KW - Opportunistic infections KW - Pathology KW - pneumocystosis KW - Retinitis KW - viral diseases KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - AIDS KW - cancers KW - clinical picture KW - european blastomycosis KW - human immunodeficiency virus infections KW - Ophthalmology KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942024237&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Synthesis of 11-[³H]-arteether, an experimental antimalarial drug. AU - Pu, Y. M. AU - Ziffer, H. JO - Journal of Labelled Compounds and Radiopharmaceuticals JF - Journal of Labelled Compounds and Radiopharmaceuticals Y1 - 1993/// VL - 33 IS - 11 SP - 1013 EP - 1018 SN - 0362-4803 AD - Pu, Y. M.: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801121. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 75887-54-6, 63968-64-9. Subject Subsets: Botanical Pesticides; Protozoology N2 - The triphenylphosphine hydrobromide-catalyzed addition of a proton from ethanol to anhydrodihydroartemisinin was employed for the synthesis of a β-arteether derivative and 11-epi-βarteether. Use of 1.5 equivalents of EtO²H or EtO³H yielded 11-[²H]- or 11-[³H]-β-arteether as the major product. KW - antimalarials KW - antiprotozoal agents KW - arteether KW - ARTEMISININ KW - derivatives KW - human diseases KW - malaria KW - novel antiprotozoal agents KW - parasites KW - synthesis KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - artemisinine KW - qinghaosu KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801121&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolic rate and body composition of Pima Indian and Caucasian children. AU - Fontvieille, A. M. AU - Ravussin, E. JO - CRC Critical Reviews in Food Science and Nutrition JF - CRC Critical Reviews in Food Science and Nutrition Y1 - 1993/// VL - 33 IS - 4/5 SP - 363 EP - 368 SN - 1040-8398 AD - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19941411293. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - A low metabolic rate for a given body size and body composition may be a risk factor for body weight gain. Because the prevalence of obesity exceeds 75% in the Pima Indian population, body composition (bioelectrical resistance) and resting metabolic rate (RMR) of 43 Pima Indian children (9.9±1.1 years old) and 42 Caucasian children (9.7±1.2 years old) were investigated. Pima Indian children were taller (P<0.001), heavier (P<0.001) and fatter (P<0.0001) than Caucasian children. Absolute values of RMR were higher in the Pimas than in the Caucasians (P<0.001), but were similar when adjusted for differences in body size, body composition and sex. In Pima Indian girls before puberty (<10 years old; n = 8), adjusted values of RMR were negatively correlated with the mean body mass index (BMI) of the parents (r = -0.88; P<0.005). As resting metabolic rate was not low in Pima children, it is suggested that the major factors in the weight gain of 10-year-old Pima children may be reduced physical activity and/or excess energy intake. However, the possibility that a low metabolic rate may be a predisposing factor at an earlier age was not excluded. KW - body composition KW - children KW - ethnic groups KW - metabolism KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Workshop on child and adolescent obesity: what, how, and who KW - Physiology of Human Nutrition (VV120) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941411293&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NMR structure determination and intramolecular transesterification of four diacetyl taxinines which co-elute with taxol obtained from Taxus x. media Hicksii needles. AU - Chmurny, G. N. AU - Paukstelis, J. V. AU - Belinda Alvarado, A. AU - McGuire, M. T. AU - Snader, K. M. AU - Muschik, G. M. AU - Hilton, B. D. JO - Phytochemistry JF - Phytochemistry Y1 - 1993/// VL - 34 IS - 2 SP - 477 EP - 483 SN - 0031-9422 AD - Chmurny, G. N.: Chemical Synthesis and Analysis Laboratory, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19950603031. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 33069-62-4. N2 - Taxol (an antineoplastic agent) isolates from Taxus media include four taxinines which co-elute and interfere with HPLC analyses of taxol. Their structures (1,9α-dihydroxy-2α,10β-diacetoxy-5α-cinnamatetaxa-4(20),11-diene-13-one; 1,10β-dihydroxy-2α,9α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene-13-one; 2α,9α-dihydroxy-10β-13α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene and; 2α,10β-dihydroxy-9α,13α-diacetoxy-5α-cinnamatetaxa-4(20),11-diene) have been determined by 1D(1H, 13C) and 2D(DQCOSY, TOCSY, HMQC, HMBC and TROESY) NMR spectroscopy. Transacetylation between 10β and 9α on the baccatin core has been documented to occur in CDCl3 and CD3OD at 27°. Interatomic distances were obtained from TROESY build-up curves of the first compound and were compared to those obtained from a computer minimized structure. KW - antineoplastic agents KW - chemical composition KW - chemical structure KW - diterpenoids KW - foliage KW - forest trees KW - leaves KW - medicinal plants KW - paclitaxel KW - plant composition KW - trees KW - woody plants KW - plants KW - Taxaceae KW - Taxus media KW - eukaryotes KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - Taxus KW - Taxaceae KW - chemical constituents of plants KW - cytotoxic agents KW - drug plants KW - medicinal herbs KW - officinal plants KW - taxinines KW - taxol KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950603031&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods. AU - Ikewaki, K. AU - Rader, D. J. AU - Schaefer, J. R. AU - Fairwell, T. AU - Zech, L. A. AU - Brewer, H. B., Jr. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1993/// VL - 34 IS - 12 SP - 2207 EP - 2215 SN - 0022-2275 AD - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941412204. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition KW - apolipoproteins KW - lipid metabolism KW - metabolism KW - methodology KW - tracer techniques KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fat metabolism KW - methods KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412204&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Coumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent. AU - Scott Samuels, D. AU - Garon, C. F. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1993/// VL - 37 IS - 1 SP - 46 EP - 50 SN - 0066-4804 AD - Scott Samuels, D.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950802817. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 4434-05-3, 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Coumermycin A1 is an inhibitor of DNA gyrase, an enzyme that catalyses supercoiling of DNA and is required for bacterial DNA replication. B. burgdorferi was shown to be more susceptible than many other eubacteria to coumermycin; this contrasted with its relative resistance to the DNA gyrase inhibitors nalidixic acid, oxolinic acid, and ciprofloxacin. Coumermycin at 0.2 μg/ml inhibited the growth of B. burgdorferi B31 in BSK II medium. A 100-fold-lower concentration induced the relaxation of 2 negatively supercoiled circular plasmids within 2 hours. Plasmid supercoiling was restored within 2 h of removal of coumermycin. These results suggest that B. burgdorferi has a DNA gyrase and that this enzyme's activity is required for growth. Structural analogues of coumermycin might be considered for use in the treatment of Lyme borreliosis. KW - antibiotics KW - coumamycin KW - DNA KW - DNA replication KW - drug therapy KW - human diseases KW - Lyme disease KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - chemotherapy KW - coumerins KW - coumermycin KW - deoxyribonucleic acid KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802817&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection. AU - Kovacs, J. A. AU - Powell, F. AU - Voeller, D. AU - Allegra, C. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1993/// VL - 37 IS - 6 SP - 1227 EP - 1231 SN - 0066-4804 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19940803533. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 36703-88-5. Subject Subsets: Protozoology; Medical & Veterinary Mycology N2 - Isoprinosine has been reported to decrease the progression of AIDS in HIV-infected patients, primarily by preventing Pneumocystis carinii pneumonia (PCP), but the mechanism of action is unknown. Para-Acetamidobenzoic acid (PAcBA) is a component of isoprinosine structurally related to para-aminobenzoic acid (PABA), a precursor of de novo folate synthesis. This pathway is known to be important for P. carinii because sulfonamides, which are effective anti-P. carinii agents, inhibit incorporation of PABA into folate precursors by the enzyme dihydropteroate synthetase (DHPS). Inhibition of P. carinii DHPS by PAcBA was investigated by using two assays. In short term cultures of P. carinii from rats, [³H]PABA incorporation into reduced folates was inhibited by both isoprinosine and PAcBA free acid. However, it was found that a soluble PAcBA salt was more potent than PAcBA free acid alone. In a rat model of PCP, the PAcBA salt administered intraperitoneally demonstrated no activity against established PCP either alone or when in combination with trimethoprim. Prevention of PCP by PAcBA through inhibition of P. carinii DHPS may explain the activity of isoprinosine in decreasing the progression of AIDS. KW - acquired immune deficiency syndrome KW - aminobenzoic acids KW - antifungal agents KW - antifungal properties KW - antiprotozoal agents KW - folate antagonists KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - Immunomodulators KW - infections KW - inosine pranobex KW - laboratory animals KW - lungs KW - mode of action KW - opportunistic infections KW - parasites KW - pneumonia KW - respiratory diseases KW - sulfonamides KW - treatment KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - rats KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - Muridae KW - rodents KW - AIDS KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - lung diseases KW - para-acetamidobenzoic acid KW - sulphonamides KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Host Resistance and Immunity (HH600) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803533&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development and characterization of a rapid screening assay for identifying antipneumocystis agents. AU - Martínez, A. AU - Kovacs, J. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1993/// VL - 37 IS - 8 SP - 1674 EP - 1678 SN - 0066-4804 AD - Martínez, A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200170. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 1397-89-3, 95233-18-4, 100-33-4, 140-64-7, 723-46-6, 738-70-5. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - A rapid assay was developed for the screening of compounds with potential anti-Pneumocystis activity on the basis of incorporation of [35S]methionine into proteins newly synthesized by P. carinii. Unambiguous evidence that P. carinii synthesizes proteins in vitro was provided by immunoprecipitation studies demonstrating the incorporation of [35S]methionine into the major surface glycoprotein. Treatment with 2 clinically active anti-Pneumocystis agents, atovaquone (10-4M) or pentamidine (10-4M), prevented this incorporation. Total [35S]methionine incorporation paralleled incorporation into the major surface glycoprotein, permitting rapid assessment of anti-P.carinii activity by scintillation counting. Treatment with pentamidine (1 × 10-4M), atovaquone, trimethoprim (1 × 10-4M)-sulfamethoxazole (7.9 × 10-4M), piritrexim (1 × 10-7M), RO11-8958 [epiroprim] (1 × 10-4M) and amphotericin B (1 µg/ml) resulted in a greater than 67% inhibition (P<0.05) of [35S]methionine incorporation. No decrease in [35S]methionine incorporation was seen with dapsone (10-5M), trimethoprim (10-4M), recombinant mouse tumor necrosis factor (500 ng/ml) or gamma interferon. It is concluded that this rapid in vitro assay should be a useful adjunct in the development of new anti-Pneumocystis agents. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - atovaquone KW - drugs KW - parasites KW - pentamidine KW - sulfamethoxazole KW - techniques KW - testing KW - trimethoprim KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - anti-fungal properties KW - epiroprim KW - fungicidal properties KW - fungistats KW - fungus KW - medicines KW - pharmaceuticals KW - piritrexim KW - Ro 11-8958 KW - sulphamethoxazole KW - susceptibility testing KW - trimethoprim sulfamethoxazole KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The challenge of Pneumocystis carinii culture. AU - Sloand, E. AU - Laughon, B. AU - Armstrong, M. AU - Bartlett, M. S. AU - Blumenfeld, W. AU - Cushion, M. AU - Kalica, A. AU - Kovacs, J. A. AU - Martin, W. AU - Pitt, E. AU - Pesanti, E. L. AU - Richards, F. AU - Rose, R. AU - Walzer, P. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1993/// VL - 40 IS - 2 SP - 188 EP - 195 SN - 1066-5234 AD - Sloand, E.: National Heart, Lung and Blood Institute, Building 31, Room 5A48, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804891. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology N2 - Published and unpublished data on the cultivation of P. carinii, both in cell-free systems and with feeder cells, were reviewed by a panel of investigators convened by the National Institutes of Health. Although several cell culture systems allow propagation of P. carinii for a limited time with modest rates of replication, these have not proved adequate for isolation of P. carinii in sufficient quantity to explore important basic biological investigation. Attempts at cell-free culture have yielded only transient proliferation. The unsuccessful work on cultivation of the organism has been unpublished, although the panel agreed that these data may be useful to other investigators in designing experimental strategies for cultivation. The purpose of this report is therefore to make available this information to researchers and prevent repetition of unsuccessful methods. It is hoped that by documenting the history and the complexities of Pneumocystis culture, renewed interest and efforts will be directed toward this scientific challenge. KW - culture techniques KW - Human diseases KW - Opportunistic infections KW - parasites KW - reviews KW - techniques KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804891&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nine-year follow-up study of a plasma-derived hepatitis B vaccine in a rural African setting. AU - Tabor, E. AU - Cairns, J. AU - Gerety, R. J. AU - Bayley, A. C. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1993/// VL - 40 IS - 3 SP - 204 EP - 209 SN - 0146-6615 AD - Tabor, E.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050584. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - One hundred and one of 255 recipients of a plasma-derived hepatitis B vaccine were evaluated in 1990, 9 years after the first vaccine dose in a study in Zambia to evaluate the efficacy of one, two or three doses. In 1983, 2 years after the first vaccine dose, antibody to the hepatitis B surface antigen (anti-HBs) had been detectable in 90 of these 101 participants (89%). In 1990, anti-HBs was still detectable in 72 of 101 (71%), and was present at a protective level (≥10 mIU/ml) in 68 of 101 (87%). Although the original vaccine study elicited a protective level of antibody in a greater percentage of children and adolescents than in adults, there were no significant differences among the three groups at 9 years. (In 1990, anti-HBs was still detectable in 52 of 70 (74%) who had had no serologic markers of the hepatitis B virus in 1981, and a protective level was detected in 47 of 70 (67%)). A protective level of anti-HBs was detected in 1990 in 26 of 36 (72% recipients of three doses and in 23 of 31 (74%) recipients of two doses; the slightly lower prevalence among recipients of one dose (19 of 34 (56%)) was not statistically significant. However, between the years 1983-1990, hepatitis B virus infections had occurred in one of 36 (3%) of those who had been vaccinated with three doses, one of 31 (3%) vaccinated with two doses, and eight of 34 (24%) of those vaccinated with one dose (P <0.02) for either two or three doses compared with one dose). These data support the long-term immunogenicity and protective efficacy of a two- or three-dose regimen of the hepatitis B vaccine in a rural African setting. KW - hepatitis B KW - immunization KW - vaccines KW - Africa KW - Zambia KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - Southern Africa KW - Africa South of Sahara KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050584&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A redescription of Entamoeba histolytica Schaudinn, 1903 (Emended Walker, 1911) separating it from Entamoeba dispar Brumpt, 1925. AU - Diamond, L. S. AU - Clark, C. G. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1993/// VL - 40 IS - 3 SP - 340 EP - 344 SN - 1066-5234 AD - Diamond, L. S.: Laboratory of Parasitic Diseases, Building 4/Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806852. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Protozoology N2 - The existence of 2 morphologically identical species of Entamoeba histolytica was first proposed by Brumpt in 1925. This study reexamines Brumpt's claim in the light of recent biochemical, immunological and genetic studies and it is concluded that the data derived from these investigations provide unequivocal evidence supporting his hypothesis. Consequently, the invasive parasite is redescribed, retaining the name Entamoeba histolytica, and is set apart from the noninvasive parasite, Entamoeba dispar. KW - chemotaxonomy KW - DNA probes KW - Human diseases KW - Monoclonal antibodies KW - Morphology KW - parasites KW - Pathogenicity KW - Polymerase chain reaction KW - redescriptions KW - Taxonomy KW - Zymodemes KW - Entamoeba dispar KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical taxonomy KW - Entamoebidae KW - PCR KW - systematics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806852&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hydrolase compartmentalization limits rate of digestion in Acanthamoeba. AU - Hohman, T. C. AU - Bowers, B. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1993/// VL - 40 IS - 5 SP - 589 EP - 593 SN - 1066-5234 AD - Hohman, T. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room B1-22, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803197. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology N2 - The kinetics of lysosomal enzyme acquisition by newly formed phagosomes was studied by following the rate of digestion of radiolabelled yeast fed to Acanthamoeba castellanii. The distribution of hydrolases among phagosomes was assessed by electron microscopic acid phosphatase cytochemistry and by measurement of 3 glycosidases in isolated early and late phagosomes. The results show that compartmentalization of hydrolases limit the digestion of large phagocytic loads. The hydrolases appear to be sequestered into the early phagosomes and not to be distributed either by small vesicle transport or phagosome-phagosome fusion to those formed later. From these results it is inferred that newly internalized surface membrane in phagosomes is not rapidly randomized with internal pools, but is recycled to the surface as a function of the digestive process. KW - biochemistry KW - digestion KW - enzymes KW - hydrolases KW - parasites KW - Acanthamoeba castellanii KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803197&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Norepinephrine turnover and energy expenditure in Pima Indian and white men. AU - Christin, L. AU - O'Connell, M. AU - Bogardus, C. AU - Danforth, E., Jr. AU - Ravussin, E. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1993/// VL - 42 IS - 6 SP - 723 EP - 729 SN - 0026-0495 AD - Christin, L.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th St, Room 541, Phoenix AZ 85016, USA. N1 - Accession Number: 19941409148. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 51-40-1, 51-41-2, 69815-49-2. Subject Subsets: Human Nutrition N2 - There is growing evidence of the involvement of sympathetic nervous system (SNS) activity in determining metabolic rate. Whole-body plasma norepinephrine turnover and its relation to resting metabolic rate (RMR) and 24-h energy expenditure (24EE) were compared in 14 Pima Indian men (25±4 years old, 96±33 kg, 25±9% fat) and 9 white men (25±3 years old, 88±43 kg, 17±13% fat). Plasma norepinephrine turnover rate correlated strongly with body surface area (r = 0.76 and 0.54 for clearance and appearance, respectively) and fat-free mass (r = 0.74 and 0.52, respectively). However, independent of body size, there was no difference in norepinephrine clearance or appearance rates between Pima Indian and white men. Norepinephrine appearance rate correlated positively with absolute values of 24EE and RMR, but not when adjusted for differences in body surface area or fat-free mass. However, norepinephrine appearance rate adjusted for differences in body size correlated with spontaneous physical activity. Results indicate that Pima Indian and white men have similar plasma norepinephrine appearance rates, but Pima Indians tend to be more resistant to β-adrenergic stimulation. Although energy expenditure and SNS activity were not directly related, a higher SNS tone may promote or reflect elevated levels of spontaneous physical activity and therefore influence energy balance and body composition. KW - body composition KW - energy exchange KW - ethnic groups KW - men KW - norepinephrine KW - obesity KW - physical activity KW - sympathetic nervous system KW - turnover KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - noradrenaline KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A standard procedure for measuring pellet hardness of rodent diets. AU - Thigpen, J. E. AU - Locklear, J. AU - Romines, C. AU - Taylor, K. A. AU - Yearby, W. AU - Stokes, W. S. JO - Laboratory Animal Science JF - Laboratory Animal Science Y1 - 1993/// VL - 43 IS - 5 SP - 488 EP - 491 SN - 0023-6764 AD - Thigpen, J. E.: Comparative Medicine Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19951407368. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Animal Nutrition; Human Nutrition N2 - A Chatillon Model TCM-200 test stand with exchangeable flat horizontal or concave receptacle bases and a DFI-200 gauge load cell with multiple types of upper exchangeable test jaws (large round-flat, medium round-flat, chisel, bullet, and cone-shaped) were compared by using preautoclaved and autoclaved NIH-31 rodent diet pellets to determine which type of hardness testing system would give the most accurate and reproducible results for measuring pellet hardness. The type and size of the contact area of the upper jaws significantly affected the force required to break the pellets. Significant differences were observed between the flat-horizontal and concave receptacle bases in the force required to break the pellets when using the two round-flat upper jaws. In contrast, similar results were obtained with both bases when the bullet, chisel, or cone-shaped upper jaws were used. Autoclaved pellets were 69.4% (range, 49 to 94%) harder than preautoclaved pellets. These results suggest that different testing systems can be used for measuring pellet hardness and that a standard procedure must be used in order to compare pellet hardness results between different testing laboratories. It was concluded that the flat-horizontal base and the larger round-flat end upper jaw gave the most reproducible results for measuring pellet hardness. KW - analytical methods KW - diet KW - hardness KW - pellets KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - Techniques and Methodology (ZZ900) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407368&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnostic exercise: gastritis in athymic nude mice [Candida albicans]. AU - Dixon, D. AU - Goelz, M. F. AU - Locklear, J. AU - Myers, P. H. AU - Thigpen, J. E. JO - Laboratory Animal Science JF - Laboratory Animal Science Y1 - 1993/// VL - 43 IS - 5 SP - 497 EP - 499 SN - 0023-6764 AD - Dixon, D.: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19932294218. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Animal Nutrition; Veterinary Science; Medical & Veterinary Mycology N2 - An outbreak of gastritis is reported in laboratory mice, which were found moribund or dead during a period of 10 months. Four of 15 male, athymic, nude mice were found dead and were diagnosed with bacterial septicaemia based on light microscopic or microbiological examination. Post-mortem examination revealed a thickened forestomach and pseudomembrane formation on the mucosal surface. Gross lesions associated with the changes in the forestomach were not found in other organs. Within the layers of the forestomach mucosa were numerous septated filamentous structures and budding ovoid organisms that stained positively with periodic acid-Schiff and Grocott methenamine silver stain. Candida albicans was cultured from forestomach scrapings. KW - case reports KW - digestive tract KW - gastritis KW - hosts KW - infections KW - laboratory animals KW - mycoses KW - pathology KW - stomach diseases KW - USA KW - Candida KW - Candida albicans KW - mice KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungus KW - gastrointestinal tract KW - Hyphomycetes KW - United States of America KW - Laboratory Animal Science (LL040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Nutrition (Physiology) (LL510) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932294218&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased immunogenicity and protective efficacy in outbred and inbred mice by strategic carboxyl-terminal truncation of Japanese encephalitis virus envelope glycoprotein. AU - Jan LeiRon AU - Yang CzauSiung AU - Henchal, L. S. AU - Sumiyoshi, H. AU - Summers, P. L. AU - Dubois, D. R. AU - Lai ChingJuh JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1993/// VL - 48 IS - 3 SP - 412 EP - 423 SN - 0002-9637 AD - Jan LeiRon: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930516339. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - Recombinant vaccinia viruses expressing the full-length envelope (E) glycoprotein of Japanese encephalitis virus (JEV) or a strategically truncated E glycoprotein, approximately 80% of the N-terminal sequence, were constructed and their antigenic structure and protective immunity in mice compared. The truncation site in the JEV E glycoprotein sequence corresponds to the position that had been shown to increase the immunogenicity of dengue type 4 or type 2 virus E glycoprotein. Analysis of the JEV E glycoprotein in recombinant virus-infected cells showed that C-terminally truncated E retains an antigenic structure similar to that of the full-length E glycoprotein. The full-length JEV E glycoprotein was detected predominantly intracellularly, while a small fraction (<2%) was present on the cell structure. On the other hand, the truncated 80% E glycoprotein exhibited an alteration in the intracellular transport pathway resulting in increased accumulation (10-25%) on the cell surface and secretion (6-10%) into the medium. The C-terminally truncated E glycoprotein induced a greater antibody response and a higher level of protective immunity than did the full-length E glycoprotein in outbred CD-1 mice as well as in 2 strains of inbred mice that differ in their resistance to intraperitoneal (ip) JEV infection. In the case of outbred CD-1 and inbred C57/B1 mice, which possess a dominant autosomal genetic locus that controls resistance to a high dose of ip infection of JEV or the capacity to acquire resistance to intracerebral JEV infection, truncated E glycoprotein induced a higher titre of JEV neutralizing antibodies. KW - Arboviruses KW - Glycoproteins KW - immunization KW - Laboratory animals KW - Vaccines KW - Viral diseases KW - Viral proteins KW - Flavivirus KW - Japanese encephalitis virus KW - mice KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Flavivirus KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - immune sensitization KW - immunogenicity KW - viral infections KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930516339&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biology and pathology of Schistosoma mansoni and Schistosoma japonicum infections in several strains of nude mice. AU - Cheever, A. W. AU - Eltoum, I. S. AU - Andrade, Z. A. AU - Cox, T. M. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1993/// VL - 48 IS - 4 SP - 496 EP - 503 SN - 0002-9637 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930806467. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Tropical Diseases; Helminthology N2 - Schistosoma mansoni and S. japonicum infections in nude mice (nu/nu) were compared with infections in nu/+ heterozygotes or intact mice. Seven to 12 weeks after the exposure to S. mansoni, the responses of Swiss NCR, C3H, BALB/c and C57BL/6 nude mice did not differ substantially. Nude mice of all these strains showed minute granulomata around ova in the liver and minimal hepatic fibrosis. Microvesicular and necrotizing changes in hepatocytes were similar in all mouse strains, and S. mansoni infections were frequently lethal to nude, but not to intact mice between the 7th and 9th weeks of infection. Nude mice that survived the 9th week of infection generally lived until the 12th week. The number of ova/mature worm pair in the tissues of S. mansoni-infected nude mice was similar to the number in intact mice, but nude mice passed fewer ova in the faeces. Nude mice that received serum from infected intact mice excreted ova in the stool in numbers equivalent to intact mice, but continued to form minute granulomata around S. mansoni ova. Reconstitution with fetal thymus or with splenocytes from normal or S. mansoni-infected mice partially or completely restored hepatic granuloma size, granuloma eosinophils, hepatic fibrosis, and excretion of ova in the faeces. In contrast to S. mansoni infection, S. japonicum infections in nude mice did not cause necrosis of hepatocytes or excessive mortality, and S. japonicum ova were passed in the faeces in numbers equivalent to those passed by infected intact mice.\From AS<new para>ADDITIONAL ABSTRACT:<new para>Schistosoma mansoni and S. japonicum infections in nude mice (nu/nu) were compared with infections in nu/+ heterozygotes or intact mice. Seven to 12 weeks after the exposure to S. mansoni, the responses of Swiss NCR, C3H, BALB/c and C57B1/6 nude mice did not differ substantially. Nude mice of all these strains showed minute granulomata around ova in the liver and minimal hepatic fibrosis. Microvesicular and necrotizing changes in hepatocytes were similar in all mouse strains, and S. mansoni infections were frequently lethal to nude, but not to intact mice between the 7th and 9th weeks of infection. Nude mice that survived the 9th week of infection generally lived until the 12th week. The number of ova/mature worm pair in the tissues of S. mansoni-infected nude mice was similar to the number in intact mice, but nude mice passed fewer ova in the faeces. Nude mice that received serum from infected intact mice excreted ova in the stool in numbers equivalent to intact mice, but continued to form minute granulomata around S. mansoni ova. Reconstitution with fetal thymus or with splenocytes from normal or S. mansoni-infected mice partially or completely restored hepatic granuloma size, granuloma eosinophils, hepatic fibrosis, and excretion of ova in the faeces. In contrast to S. mansoni infection, S. japonicum infections in nude mice did not cause necrosis of hepatocytes or excessive mortality, and S. japonicum ova were passed in the faeces in numbers equivalent to those passed by infected intact mice. KW - Experimental infections KW - helminths KW - Human diseases KW - immunocompromised hosts KW - Laboratory animals KW - parasites KW - pathogenesis KW - pathology KW - schistosomiasis KW - strain differences KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - Granulomas KW - nude mice KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of agricultural pesticide use in the development of non-Hodgkin's lymphoma in women. AU - Zahm, S. H. AU - Weisenburger, D. D. AU - Saal, R. C. AU - Vaught, J. B. AU - Babbitt, P. A. AU - Blair, A. JO - Archives of Environmental Health JF - Archives of Environmental Health Y1 - 1993/// VL - 48 IS - 5 SP - 353 EP - 358 SN - 0003-9896 AD - Zahm, S. H.: Occupational Studies Section, National Cancer Institute, Executive Plaza North, Room 418, Rockville, MD 20892, USA. N1 - Accession Number: 19942027294. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health N2 - Non-Hodgkin's lymphoma has been found to be associated with agricultural pesticide use in men, but little is known about the risk in women. In a recent population-based, case-control study conducted in eastern Nebraska [USA], no increased risk of non-Hodgkin's lymphoma was found in women who had ever lived or worked on a farm (odds ratio [OR] = 1.0). Neither the use of insecticides (OR = 0.8) nor herbicides (OR = 0.7) on the farm was associated with non-Hodgkin's lymphoma; however, the number of women who mixed or applied pesticides was small, particularly in comparison to men on farms. Small non-significant associations were observed among the women who personally handled insecticides (OR = 1.3) or herbicides (OR = 1.2). Women who personally handled organophosphate insecticides had a significant 4.5-fold increased risk of non-Hodgkin's lymphoma. Use of chlorinated hydrocarbon insecticides was associated with an OR of 1.6; however, the use on dairy cattle was associated with a 3-fold increased risk. Pesticide-related risks were greater among women with a family history of cancer, particularly a history of lymphatic or haematopoietic cancer among first-degree relatives. AS<new para>ADDITIONAL ABSTRACT:<new para>Non-Hodgkin's lymphoma has been found to be associated with agricultural pesticide use in men, but little is known about the risk in women. In a recent population-based, case-control study conducted in eastern Nebraska, USA, no increased risk of non-Hodgkin's lymphoma was found in women who had ever lived or worked on a farm (odds ratio [OR] = 1.0). Neither the use of insecticides (OR = 0.8) nor herbicides (OR = 0.7) on the farm was associated with non-Hodgkin's lymphoma; however, the number of women who mixed or applied pesticides was small, particularly in comparison to men on farms. Small nonsignificant associations were observed among the women who personally handled insecticides (OR - 1.3) or herbicides (OR = 1.2). Women who personally handled organophosphate insecticides had a significant 4.5-fold increased risk of non-Hodgkin's lymphoma. Use of chlorinated hydrocarbon insecticides was associated with an OR of 1.6; however, the use on dairy cattle was associated with a 3-fold increased risk. Pesticide-related risks were greater among women with a family history of cancer, particularly a history of lymphatic or haematopoietic cancer among first-degree relatives. KW - dairy cattle KW - epidemiology KW - farm workers KW - herbicides KW - insecticides KW - lymphoma KW - non-Hodgkin's lymphoma KW - occupational hazards KW - organochlorine insecticides KW - organophosphorus insecticides KW - pesticides KW - risk factors KW - Toxicology KW - women KW - Nebraska KW - North America KW - USA KW - cattle KW - man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Northern Plains States of USA KW - West North Central States of USA KW - North Central States of USA KW - United States of America KW - weedicides KW - weedkillers KW - Occupational Health and Safety (VV900) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Women (UU500) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027294&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Acute leukemia and residential proximity to potential sources of environmental pollutants. AU - Shore, D. L. AU - Sandler, D. P. AU - Davey, F. R. AU - McIntyre, O. R. AU - Bloomfield, C. D. JO - Archives of Environmental Health JF - Archives of Environmental Health Y1 - 1993/// VL - 48 IS - 6 SP - 414 EP - 420 SN - 0003-9896 AD - Shore, D. L.: (D. Sandler) National Institute of Environmental Health Sciences, Mail Drop A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19942027286. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Possible associations between location of residence and acute leukaemia risk were investigated in a study of 610 newly diagnosed patients [from Canada and the USA], aged 18-79 years, and 618 population controls. There was an association between ever living within 5 miles (8 km) of an industrial plant and leukaemia risk, with adjusted odds ratios (ORs) of 1.4 (95% confidence interval [95% CI] = 1.0-1.9) for all acute leukaemias combined, 1.4 (95% CI = 1.0-2.0) for acute myeloid leukaemia, and 1.7 (95% CI = 1.0-2.7) for acute lymphocytic leukaemia. Odds ratios increased with decreasing distance from industrial sites, but a gradient with duration of residence was seen only among those less than age 60 who had lived within a mile of any industry. Suggestive associations were also observed for residence near specific industries, but the number of individuals living near any one industry was small.AS KW - industrial sites KW - Leukaemia KW - risk factors KW - Canada KW - North America KW - USA KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood cancer KW - leucaemia KW - leukemia KW - United States of America KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027286&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regression of hepatic lesions after treatment of Schistosoma mansoni or Schistosoma japonicum infection in mice: a comparative study. AU - Andrade, Z. A. AU - Cox, T. M. AU - Cheever, A. M. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1993/// VL - 49 IS - 1 SP - 1 EP - 9 SN - 0002-9637 AD - Andrade, Z. A.: (A.W. Cheever) Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19940800238. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 55268-74-1. Subject Subsets: Helminthology; Tropical Diseases N2 - Experimental infections with Schistosoma mansoni and S. japonicum differ in several aspects and post-treatment resorption of fibrosis might be one of them. To investigate this point, mice infected with each of these schistosome species were treated with praziquantel and the evolution of hepatic lesions was sequentially followed for 5 months. Parasitologic data showing destruction of worms and eggs and biochemical findings of progressively decreased collagen concentration after cure indicated that the lesions caused by S. mansoni and S. japonicum involuted in a similar fashion following chemotherapy. The time sequence of the histologic changes indicative of decreasing inflammation and progressive matrix degradation and resorption was also similar in both cases.AS<new para>ADDITIONAL ABSTRACT:<new para>Experimental infections with Schistosoma mansoni and S. japonicum differ in several aspects and post-treatment resorption of fibrosis might be one of them. To investigate this point, mice infected with each of these schistosome species were treated with praziquantel and the evolution of hepatic lesions was sequentially followed for 5 months. Parasitologic data showing destruction of worms and eggs and biochemical findings of progressively decreased collagen concentration after cure indicated that the lesions caused by S. mansoni and S. japonicum involuted in a similar fashion following chemotherapy. The time sequence of the histologic changes indicative of decreasing inflammation and progressive matrix degradation and resorption was also similar in both cases. KW - anthelmintics KW - disease models KW - drug therapy KW - experimental infections KW - helminths KW - human diseases KW - laboratory animals KW - Lesions KW - Liver KW - parasites KW - pathology KW - praziquantel KW - schistosomiasis KW - Treatment KW - Digenea KW - Mice KW - Muridae KW - rodents KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - chemotherapy KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800238&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human retroviruses in Amerindians of Colombia: high prevalence of human T cell lymphotropic virus type II infection among the Tunebo Indians. AU - Duenas-Barajas, E. AU - Bernal, J. E. AU - et al. AU - Vaught, D. R. ( JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1993/// VL - 49 IS - 6 SP - 657 EP - 663 SN - 0002-9637 AD - Duenas-Barajas, E.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028007. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - The coexistence of infection with human T lymphotropic virus types I and II (HTLV-I and HTLV-II) has been demonstrated recently among the Wayuu Indians from the Guajira region of Colombia. To ascertain if other Indian groups in Colombia are similarly infected, [the authors] tested 1250 sera, collected between 1990 and 1992 from 18 culturally distinct Amerindian tribes living in widely separated regions, for IgG antibodies against HTLV-I/II using enzyme-linked immunosorbent assay (ELISA) and Western blot. Sera were also tested for antibodies against human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) to investigate the overall burden of retrovirus infection in these semi-isolated indigenous groups. A total of 33 of the 1250 samples were repeatedly reactive to HTLV-I/II antigens by ELISA, and of these, three sera from Waunana/Noanama Indians from the Choco area and two sera from Tunebo Indians from the Santander region were found to be infected with HTLV-I and HTLV-II, respectively, as verified by Western blot and differential ELISA. Thus, despite the small sample size, the overall seroprevalences for HTLV-I and HTLV-II infection among the Waunana/Noanama and Tunebo Indians were 2.1% and 5.0%, respectively. In contrast, none of the 29 Indians who exhibited reactivity to HIV-1/2 by ELISA were seropositive by Western blot. This study adds the Tunebo to the expanding list of Amerindian groups with high prevalences of HTLV-II infection. Further intensive investigations of such indigenous populations will clarify the natural history and disease potential of HTLV-II infection. AS KW - American Indians KW - Colombia KW - South America KW - Deltaretrovirus KW - Human T-cell lymphotropic virus type II KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - HTLV-BLV group KW - prevalence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028007&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neurological manifestations of malaria. AU - Roman, G. C. AU - Senanayake, N. JO - Arquivos de Neuro-Psiquiatria JF - Arquivos de Neuro-Psiquiatria Y1 - 1993/// VL - 50 IS - 1 SP - 3 EP - 9 SN - 0004-282X AD - Roman, G. C.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, (NINDS), National Institutes of Health, (NIH), Bethesda, MD 20892, USA. N1 - Accession Number: 19940800507. Publication Type: Journal Article. Language: English. Language of Summary: Portuguese. Number of References: 42 ref. Subject Subsets: Protozoology N2 - Neurological manifestations of malaria are reviewed under the headings: cerebral malaria; other cerebral manifestations; hypoglycaemia; delayed cerebellar ataxia; epilepsy; febrile seizures; spinal cord disorders; peripheral neuropathy; periodic paralysis. KW - Cerebral malaria KW - Human diseases KW - Malaria KW - Nervous system KW - parasites KW - pathology KW - reviews KW - Apicomplexa KW - man KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - neurological manifestations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800507&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Non-Hodgkin's lymphoma and occupation in Sweden: a registry based analysis. AU - Linet, M. S. AU - Malker, H. S. R. AU - et al. AU - McLaughlin, J. K. ( JO - British Journal of Industrial Medicine JF - British Journal of Industrial Medicine Y1 - 1993/// VL - 50 IS - 1 SP - 79 EP - 84 SN - 0007-1072 AD - Linet, M. S.: National Cancer Institute, EPN 415B, Rockville, Maryland 20892, USA. N1 - Accession Number: 19942025739. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Incidence of non-Hodgkin's lymphoma in different employment categories was evaluated from the Swedish Cancer-Environment Registry, which links cancer incidence during 1961 to 1979 with occupational information from the 1960 census. New associations were found for men employed in shoemaking and shoe repair, porcelain and earthenware industries, education, and other white collar occupations. Several findings supported associations found in other countries, including excesses among woodworkers, furniture makers, electric power plant workers, farmers, dairy workers, lorry drivers, and other land transport workers. Risks were not increased among chemists, chemical or rubber manufacturing workers, or petrochemical refinery workers. Caution must be used in drawing causal inferences from these linked registry data because information on exposure and duration of employment is not available. Nevertheless, this study has suggested new clues to possible occupational determinants of non-Hodgkin's lymphoma. AS KW - Non-Hodgkin's lymphoma KW - Occupational health KW - occupations KW - risk factors KW - Europe KW - Sweden KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025739&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. AU - Zheng, W. AU - Blot, W. J. AU - Diamond, E. L. AU - Norkus, E. P. AU - Spate, V. AU - Morris, J. S. AU - Comstock, G. W. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1993/// VL - 53 IS - 4 SP - 795 EP - 798 SN - 0008-5472 AD - Zheng, W.: Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941403776. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - To investigate the relation between serum micronutrients and subsequent risk of oral and pharyngeal cancer, blood samples of 25 802 adults living in Washington County, USA, were collected in 1974 and stored at -70°C for subsequent assays. Serum values of nutrients in 28 subjects who developed oral and pharyngeal cancer during 1975 to 1990 were compared with values in 112 matched controls. Serum values of carotenoids, particularly β-carotene, were lower among subjects who developed oral and pharyngeal cancer. Risk of this malignancy decreased substantially with increasing serum value of each individual carotenoid. Persons in the highest tertile of total carotenoids had about one-third the cancer risk as those in the lowest tertile. High serum α-tocopherol was related to low oral cancer risk in later years, but risks were elevated significantly with increasing serum γ-tocopherol and selenium. KW - blood KW - carcinoma KW - carotenoids KW - mouth KW - pharynx KW - selenium KW - tocopherols KW - trace elements KW - vitamins KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - microelements KW - tetraterpenoids KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403776&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Correspondence re: K.P.Cantor et. al., Pesticides and other agricultural risk factors for non-Hodgkins lymphoma among men in Iowa and Minnesota, Cancer Res., 52: 2447-2455,1992. AU - Cantor, K. P. AU - Blair, A. AU - Brown, L. M. AU - Burmeister, L. F. AU - Everett, G. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1993/// VL - 53 IS - 10 SP - 2421 EP - 2421 SN - 0008-5472 AD - Cantor, K. P.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20982, USA. N1 - Accession Number: 19951111299. Publication Type: Journal Article. Language: English. Number of References: 3 ref. N2 - This letter reports on additional findings not included in their original manuscript, as titled above. KW - Hodgkin's disease KW - insecticides KW - lymphoma KW - neoplasms KW - pesticides KW - Iowa KW - Minnesota KW - USA KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Lake States of USA KW - cancer of the lymph nodes KW - cancers KW - lymphogranuloma KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951111299&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Precancerous gastric lesions in a population at high risk of stomach cancer. AU - You, W. C. AU - Blot, W. J. AU - et al. AU - Li, J. Y. ( JO - Cancer Research JF - Cancer Research Y1 - 1993/// VL - 53 IS - Mar. 15 SP - 1317 EP - 1321 AD - You, W. C.: (W.J. Blot) National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021510. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - "A population-based screening for detection of early cancers evaluated the prevalence of precancerous gastric lesions in an area in Shandong province, China, with one of the world's highest rates of stomach cancer. A total of 3433 residents aged 35 to 64 years received gastroscopical examinations with biopsies taken from standard locations. Chronic atrophic gastritis was nearly universal; less than 2% of the population had biopsies showing entirely normal mucosa or only superficial gastritis. Intestinal metaplasia was the most advanced lesion for 33% and gastric dysplasia for 20%, although the prevalence of each increased significantly with age. Intestinal metaplasia and gastric dysplasia were detected throughout the stomach, but the lesions were more pronounced along the lesser curvature, especially in the angulus and antrum. There was no sex difference in rates of chronic atrophic gastritis, but males had a slightly higher prevalence of intestinal metaplasia, a 1.6-fold increase in dysplasia, and a 3-fold excess of gastric cancer. The data quantify the extensiveness of gastric lesions likely to be involved in the natural history of stomach cancer in this high-risk population." The authors compare their findings with those from studies in Colombia and Japan. Their study of the residents of Linqu in Shandong continues in order to quantify progression rates and in the hope of developing [much needed] preventive measures. D.W. FitzSimons KW - neoplasms KW - stomach KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - gastric lesions KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021510&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytologic screening for oesophageal cancer: results from 12 877 subjects from a high-risk population in China. AU - Shen, Q. AU - Liu, S. F. AU - Dawsey, S. M. AU - Cao, J. AU - Zhou, B. AU - Wang, D. Y. AU - Cao, S. G. AU - Zhao, H. Z. AU - Li, G. Y. AU - Taylor, P. R. AU - Guo, W. D. AU - Liu, F. S. AU - Blot, W. J. AU - Li, J. Y. AU - Li, B. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1993/// VL - 54 IS - 2 SP - 185 EP - 188 SN - 0020-7136 AD - Shen, Q.: (S. M. Dawsey) Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952000405. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - In 1983, oesophageal balloon-cytology screening was performed to identify subjects eligible for 2 nutrition-intervention trials in Linxian, China; 12 877 subjects had cytology slides which were satisfactory for diagnosis. Of the 12 649 subjects with squamous-cell diagnoses, 31% were normal by Chinese cytologic criteria; 38% showed hyperplasia; 21% showed dysplasia 1; 6% showed dysplasia 2; 2% showed near-cancer; and 2% showed cancer. Of the 1471 subjects with columnar-cell diagnosis, 31% were normal; 44% showed hyperplasia; 16% showed dysplasia 1; 4% showed dysplasia 2; 2% showed near-cancer; and 3% showed cancer. Squamous dysplasia and cancer were more common among females than males, while columnar dysplasia and cancer showed male predominance. The prevalence of dysplasia and cancer of both cell types increased with age. The prevalence of squamous dysplasia was significantly higher than in earlier balloon-cytology screenings in Linxian, probably reflecting changes in cytologic classification. KW - epidemiology KW - neoplasms KW - oesophageal cancer KW - oesophagus KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - esophagus KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000405&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer incidence trends in women at high risk of human immunodeficiency virus (HIV) infection. AU - Rabkin, C. S. AU - Biggar, R. J. AU - Baptiste, M. S. AU - Abe, T. AU - Kohler, B. A. AU - Nasca, P. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1993/// VL - 55 IS - 2 SP - 208 EP - 212 SN - 0020-7136 AD - Rabkin, C. S.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007114. Publication Type: Journal Article. Language: English. Number of References: 27 ref. N2 - To determine the types and rates of tumours which may be associated with HIV infection in women, the authors used cancer incidence data from New York and northern New Jersey, USA. The authors examined changes in incidence of selected cancers in women aged 20-49 years and compared groups differing in incidence of AIDS. Black women were compared to white women in New York City and in the remainder of New York State; for cervical cancer, rates were also compared for Blacks and Whites in northern New Jersey. The incidence of Kaposi's sarcoma in women increased in New York City, beginning in 1982 for Blacks and in 1984 for Whites, but remained stable in the remainder of New York State. The incidence of non-Hodgkin's lymphoma in New York women doubled in Blacks after 1982 whereas incidence trends in Whites were unchanged. No consistent variation was seen in the incidence of Hodgkin's disease. Cervical cancer in New York and northern New Jersey Blacks declined over the same period by approximately 40% for invasive tumours and 50% for in situ lesions. The HIV epidemic is associated with substantial excesses of Kaposi's sarcoma and non-Hodgkin's lymphoma in women. The absence of Kaposi's sarcoma in upstate New York women suggest the existence of a geographically restricted co-factor(s) for Kaposi's sarcoma in addition to HIV. If HIV affected cervical cancer incidence through 1988, its impact was small compared to the striking decreases which followed widespread adoption of Papanicolaou screening. KW - disease prevalence KW - human immunodeficiency viruses KW - infections KW - neoplasms KW - women KW - New Jersey KW - New York KW - North America KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007114&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tobacco use and nasopharyngeal carcinoma in a cohort of US veterans. AU - Chow, W. H. AU - McLaughlin, J. K. AU - Hrubec, Z. AU - Nam, J. M. AU - Blot, W. J. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1993/// VL - 55 IS - 4 SP - 538 EP - 540 SN - 0020-7136 AD - Chow, W. H.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19952007324. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - The risk of nasopharyngeal carcinoma (NPC), a relatively rare neoplasm in the USA, was examined in relation to tobacco use in a cohort of nearly 250 000 USA veterans whose mortality experience was followed for 26 years. A total of 48 NPC deaths were identified during the follow-up period. Current smokers had a nearly 4-fold increase in risk of NPC compared with non-users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC. KW - nasopharynx KW - neoplasms KW - tobacco smoking KW - veterans KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancer sites KW - cancers KW - United States of America KW - war veterans KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007324&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts. AU - Cardellina, J. H., II AU - Munro, M. H. G. AU - Fuller, R. W. AU - Manfredi, K. P. AU - Mckee, T. C. AU - Tischler, M. AU - Bokesch, H. R. AU - Gustafson, K. R. AU - Beutler, J. A. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1993/// VL - 56 IS - 7 SP - 1123 EP - 1129 SN - 0163-3864 AD - Cardellina, J. H., II: Laboratory of Drug Discovery and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19940307849. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Botanical Pesticides; Horticultural Science N2 - A chemical screening protocol, utilizing various solid-phase extraction cartridges, has been developed to screen aqueous extracts from terrestrial plants, cyanobacteria, and marine invertebrates and algae for anti-human immunodeficiency virus activity, and to assist in the prioritization of these extracts for further investigation. KW - antiviral plants KW - antiviral properties KW - extracts KW - human immunodeficiency viruses KW - plant composition KW - plant extracts KW - algae KW - cyanobacteria KW - invertebrates KW - plants KW - plants KW - aquatic plants KW - aquatic organisms KW - eukaryotes KW - Bacteria KW - prokaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - animals KW - anti-viral properties KW - bacterium KW - chemical constituents of plants KW - human immunodeficiency virus KW - Plant Composition (FF040) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biological Resources (Animal) (PP710) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940307849&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Two new cytotoxic chalcones from Calythropsis aurea. AU - Beutler, J. A. AU - Cardellina, J. H., II AU - Gray, G. N. AU - Prather, T. R. AU - Shoemaker, R. H. AU - Boyd, M. R. AU - Lin, C. M. AU - Hamel, E. AU - Cragg, G. M. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1993/// VL - 56 IS - 10 SP - 1718 EP - 1722 SN - 0163-3864 AD - Beutler, J. A.: Laboratory of Drug Discovery Research & Development, Natural Products Branch, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19950303045. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Horticultural Science N2 - The crude extract of C. aurea produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Two new chalcones, calythropsin and dihydrocalythropsin, were isolated from roots of C. aurea (collected 70 km north of Geraldton, Western Australia), following cytotoxicity-guided fractionation. Their structures were elucidated from spectral data. The most active compound, calythropsin, was weakly cytotoxic, and was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization. KW - chalcones KW - chemical structure KW - cytotoxic compounds KW - cytotoxicity KW - medicinal plants KW - mitogens KW - plant composition KW - plant extracts KW - roots KW - spectral analysis KW - tubulin KW - Australia KW - Myrtaceae KW - Myrtales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - Calythropsis aurea KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950303045&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of phenylpropanolamine on energy expenditure and weight loss in overweight women. AU - Alger, S. AU - Larson, K. AU - Boyce, V. L. AU - Seagle, H. AU - Fontvieille, A. M. AU - Ferraro, R. T. AU - Rising, R. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1993/// VL - 57 IS - 2 SP - 120 EP - 126 SN - 0002-9165 AD - Alger, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19931463761. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - The effect of phenylpropanolamine (PPA), a non-catecholamine sympathomimetic weight-loss agent, on energy expenditure (EE) and substrate oxidation was estimated in a respiratory chamber in 24 overweight women, 18 to 49 years old, after 4 days of treatment (PPA or placebo) during weight maintenance and after 7 weeks of treatment on a hypoenergetic diet (70% of estimated baseline 24-h EE). 12 women (37±2 years old, 74±6 kg, 33±1% body fat) were randomly assigned to the PPA group (75 mg osmotic release oral system (OROS)-PPA daily) and 12 (38±2 years old, 79±1 kg, 37±1% body fat) to the placebo group. Baseline measurements of 24-h EE (7849±226 vs. 7834±142 kJ/day), basal metabolic rate (BMR) and 24-h respiratory quotient (RQ) were comparable between PPA and placebo groups. After 4 days of treatment, there was no significant effect of PPA on 24-h EE, BMR and 24-h RQ compared with placebo. During the 7-week diet period, however, the PPA group (n=8) had greater weight loss than the placebo group (n=10): -5.0±0.5 vs. -3.0±0.4 kg (P<0.05). The changes in 24-h EE and 24-h RQ during the 7 weeks were not different between the groups. It is concluded that weight loss is enhanced by OROS-PPA, but this change was not explained by changes in 24-h EE or 24-h RQ. The small number of subjects may have hindered detection of subtle differences in energy metabolism. KW - drug therapy KW - energy exchange KW - obesity KW - weight reduction KW - Women KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Pesticides and Drugs (General) (HH400) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931463761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification, isolation, and characterization of naturally-occurring Trypanosoma cruzi variants. AU - McDaniel, J. P. AU - Dvorak, J. A. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 57 IS - 2 SP - 213 EP - 222 SN - 0166-6851 AD - McDaniel, J. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930803009. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology; Tropical Diseases N2 - Naturally occurring DNA variants of the single-cell-derived Y-02 stock of T. cruzi were discovered during a routine assay of the stock. Three DNA variant types were isolated. One type was indistinguishable from the parental Y-02 stock on the basis of total DNA/cell. The other 2 types contained approximately 30% and 70% more DNA/cell than the parental Y-02 stock. Both the nucleus and kinetoplast were involved in the DNA content differences. The increase in DNA/cell was not G-C- or A-T-specific and was unrelated to the developmental stage of the parasite. Epimastigote population doubling times, isoenzymes, and schizodeme analyses could not differentiate the variant stocks. However, marked karyotype polymorphisms were observed by pulse-field gel electrophoresis, and restriction-fragment-length-polymorphisms were detected in hybridizations of some endonuclease-restricted samples to the spliced leader probe. It is postulated that the Y-02 variants are genetic homologues. The ability to form viable hybrids or aneuploids provides T. cruzi with a mechanism to survive environmental stress, promote intra-specific heterogeneity and generate the diversity observed in the presentation and course of Chagas' disease. KW - Chemotaxonomy KW - culture techniques KW - DNA KW - Human diseases KW - Molecular genetics KW - parasites KW - Polymorphism KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - biochemical genetics KW - biochemical taxonomy KW - deoxyribonucleic acid KW - DNA polymorphism KW - DNA variants KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930803009&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Problems with estimating vitamin C intakes. AU - Sinha, R. AU - Block, G. AU - Taylor, P. R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1993/// VL - 57 IS - 4 SP - 547 EP - 550 SN - 0002-9165 AD - Sinha, R.: EPN Room 443, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19941400154. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition; Potatoes N2 - The vitamin C content of foods was examined from 2 US national databases and new values were obtained by HPLC. HPLC values were lower in 4 of the 5 highest vitamin C contributors to the US diet (orange juice, grapefruit, tomatoes and tomato juice, and potatoes), as well as in broccoli, red peppers, and cooked collard and mustard greens, compared with values from the other databases. When HPLC values were substituted in the Health Habits and History Questionnaire, the resulting estimates of dietary intake of vitamin C in 2 studies were lower. Despite these lower estimates of absolute intake, in one study the correlation between dietary vitamin C and plasma ascorbic acid was similar. In conclusion, the accuracy of the vitamin C content of food is important for estimating the absolute amount of vitamin C intake in the population but may not change the ranking of people in epidemiological studies. KW - ascorbic acid KW - databases KW - diet studies KW - estimation KW - food composition KW - HPLC KW - intake KW - nutrition KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - data banks KW - high performance liquid chromatography KW - United States of America KW - vitamin C KW - Information and Documentation (CC300) KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400154&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of differentially expressed genes from in vitro-grown 'amastigotes' of Leishmania donovani. AU - Joshi, M. AU - Dwyer, D. M. AU - Nakhasi, H. L. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 58 IS - 2 SP - 345 EP - 354 SN - 0166-6851 AD - Joshi, M.: Laboratory of Biochemistry, Division of Biochemistry and Biophysics, CBER, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930804493. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - An axenic culture system was used which permits the continuous generation and cycling of L. donovani from promastigotes to 'amastigotes' in vitro. cDNA libraries were constructed from poly(A)+ RNA isolated from both the promastigote and amastigote forms. Using differential cDNA hybridization techniques, 3 unique cDNA clones (P17, A41 and A45) were isolated from the amastigote library. To assess whether these clones were differentially expressed by the promastigotes or amastigotes, they were hybridized to RNA isolated from each of these parasite forms in Northern and slot-blots. Results of these analyses showed that amastigotes had about 2-fold higher levels of the A41 and A45 RNAs compared to the promastigotes. Promastigotes showed about 2-fold higher levels of the P17 RNA than amastigotes. Nucleotide sequence analysis and comparison with those in Gene bank, revealed that the 3 cDNAs represent unique leishmanial genes. Comparison of the deduced amino acid sequences revealed that: P17 open reading frame (ORF) had significant similarity with a soybean ribosomal protein S11; A41 ORF with a Bacillus subtilis spore germination gene (gerC) and A45 ORF with yeast stress-inducible protein (STI1). It is noted that, of the 3 cDNAs identified, the A45-encoded protein was recognized by sera from patients with clinically active visceral leishmaniasis and was encoded by a single copy gene.<new para>ADDITIONAL ABSTRACT:<new para>The authors report the isolation of 3 cDNA clones encoding mRNAs that are differentially expressed by in vitro derived pro- and "amastigotes". One of these mRNA encodes a protein that was recognized by sera from patients with visceral leishmaniasis.Carolyn A. Brown KW - amastigotes KW - complementary DNA KW - Developmental stages KW - Genes KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - promastigotes KW - Leishmania donovani KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cDNA KW - DNA sequences KW - gene cloning KW - growth phase KW - ribosomal protein KW - stress-inducible protein KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804493&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and expression of the gene for Plasmodium falciparum transmission-blocking target antigen, Pfs230. AU - Williamson, K. C. AU - Criscio, M. D. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 58 IS - 2 SP - 355 EP - 358 SN - 0166-6851 AD - Williamson, K. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804494. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The Pfs230 gene was cloned, sequenced and expressed in Escherichia coli. In addition to 3 tryptic peptides that were sequenced, the deduced amino acid sequence of Pfs230 coded for a 363 000 MW polypeptide with 5 distinct characteristics: consistent with Pfs230 being a non-integral membrane protein, there is a presumptive signal sequence at the amino terminus; starting at amino acid 280, there are 25 contiguous E residues; beginning with amino acid 379, a 4 amino acid (E-E-V-G) repeat is present tandemly 8 times followed by 4 copies of an 8 amino acid repeat (E-E-V-G-E-E/G-E/V-G); there are 3 regions of highly negative net charge, including amino acids 273-325, which contains the 25 E residues, amino acids 1147-1205, and amino acids 1604-1668; there are 6 copies of a 7-cysteine motif. KW - antigens KW - Genes KW - Human diseases KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - transmission blocking immunity KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - gene cloning KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804494&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of carotenoid food-composition database. AU - Forman, M. R. AU - Lanza, E. AU - Yong, L. C. AU - Holden, J. M. AU - Graubard, B. I. AU - Beecher, G. R. AU - Melitz, M. AU - Brown, E. D. AU - Smith, J. C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1993/// VL - 58 IS - 4 SP - 519 EP - 524 SN - 0002-9165 AD - Forman, M. R.: Cancer Prevention Studies Branch, Cancer Prevention Research Program, Division of Cancer Prevention and Control, National Cancer Institute, Rockville, MD 20892, USA. N1 - Accession Number: 19941405849. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition N2 - A newly available carotenoid food-composition database providing specific carotenoid values for >2300 foods was linked to dietary data on 57 male nonsmokers to examine the association between dietary carotenoid intake and plasma carotenoid concentrations during 3 weeks of free-living. Carotenoid intake was estimated from a food-frequency questionnaire (FFQ) and 7 days of food diaries (FD) with concurrent analysis of plasma carotenoid concentrations. After adjustment for energy intake, percentage of energy from alcohol, and plasma lipid concentrations, significant diet-plasma correlations for the FFQ and the FD included α-carotene, β-carotene, β-cryptoxanthin, lutein and lycopene. Dietary carotenoid intakes were associated with plasma carotenoid concentrations for all the carotenoids except for β-carotene when food diaries were used whereas the diet-plasma correlation for the provitamin A carotenoids were consistently significant when the FFQ was used. KW - blood KW - carotenoids KW - databases KW - diet study techniques KW - food composition KW - intake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - data banks KW - tetraterpenoids KW - Food Composition and Quality (QQ500) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405849&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1). AU - Miller, L. H. AU - Roberts, T. AU - Shahabuddin, M. AU - McCutchan, T. F. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 59 IS - 1 SP - 1 EP - 14 SN - 0166-6851 AD - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804760. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - All published sequences of Plasmodium falciparum merozoite surface protein (MSP-1) were aligned, identifying errors, resequencing a portion of one parasite clone, and identifying probable duplicate sequences of 4 pairs of parasite clones. The sequences are presented in a fashion that facilitates the study of variation and its potentially diverse origins. The original dimorphic sequences described by Tanabe et al. have been modified to include only common sequences throughout the entire gene. The extension of the dimorphic region of the 5′ end of block 3 brings into question the involvement of intragenic crossover as the major mechanism generating allelic diversity. Additional diversity developed from point mutations and recombination in certain regions of the gene. KW - antigens KW - Genes KW - Human diseases KW - merozoites KW - Molecular genetics KW - Nucleotide sequences KW - parasites KW - proteins KW - surface proteins KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - membrane proteins KW - merozoite surface protein KW - sequence analysis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804760&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation, structure and synthesis of conocurvone, a potent, novel HIV-inhibitory naphthoquinone trimer from Conospermum species [in particular C. incurvum]. AU - Decosterd, L. A. AU - Parsons, I. C. AU - Gustafson, K. R. AU - Cardellina, J. H., II AU - McMahon, J. AU - Cragg, G. M. AU - Murata, Y. AU - Pannell, L. K. AU - Steiner, J. R. AU - Clardy, J. AU - Boyd, M. JO - Planta Medica JF - Planta Medica Y1 - 1993/// VL - 59 IS - 7 SP - A581 EP - A581 SN - 0032-0943 AD - Decosterd, L. A.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Programm, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19940307909. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 1 ref. Subject Subsets: Botanical Pesticides; Horticultural Science KW - antiviral plants KW - antiviral properties KW - biosynthesis KW - chemical structure KW - human immunodeficiency viruses KW - inhibitors KW - medicinal plants KW - plant composition KW - quinones KW - Australia KW - plants KW - Proteaceae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - eukaryotes KW - Proteales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - anti-viral properties KW - chemical constituents of plants KW - Conospermum KW - Conospermum incurvum KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - Medicinal plant research KW - officinal plants KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) KW - Pesticides and Drugs (General) (HH400) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940307909&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Restriction polymorphisms and fingerprint patterns from an interspersed repetitive element of Plasmodium falciparum DNA. AU - Dolan, S. A. AU - Herrfeldt, J. A. AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 61 IS - 1 SP - 137 EP - 142 SN - 0166-6851 AD - Dolan, S. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940802257. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology; Tropical Diseases N2 - A recombinant DNA clone, pC4.H32, identifies distinguishable restriction fragment patterns from different Plasmodium falciparum clones. Analysis of these DNA fingerprint patterns from parasites cultivated over several years and from progeny of a P. falciparum cross showed the fingerprints to be mitotically and meiotically stable. Restriction fragments from the parents of the cross possessed sufficient polymorphism and number to generate 14 unique fingerprint patterns in 16 independent recombinant progeny. The pC4.H32 insert contains a 0.5-kb imperfectly repeated sequence found in subtelomeric regions of multiple chromosomes. Restriction site variations both within and outside of the 0.5-kb repeat contribute to the fingerprint polymorphisms. It is concluded that fingerprint analysis can serve to type P. falciparum clones and can detect mislabelling and cross-contamination of parasite stocks. KW - chemotaxonomy KW - DNA KW - DNA fingerprinting KW - human diseases KW - molecular genetics KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - biochemical taxonomy KW - deoxyribonucleic acid KW - fingerprint patterns KW - restriction polymorphism KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802257&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon. AU - Roilides, E. AU - Uhlig, K. AU - Venzon, D. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 4 SP - 1185 EP - 1193 SN - 0019-9567 AD - Roilides, E.: T. J. Walsh, Pediatric Branch, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931214402. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Medical & Veterinary Mycology N2 - To investigate the role of granulocyte colony-stimulating factor (G-CSF) and gamma interferon (IFN-γ) against A. fumigatus, their effects on the oxidative burst and capacity of normal human PMNs to damage hyphae were studied. G-CSF enhanced PMN oxidative burst measured as superoxide anion (O2-) production in response to N-formylmethionyl leucyl phenylalanine, serum opsonized hyphae and non-opsonized hyphae by 75, 37 and 24%, respectively, compared with control PMNs (P<0.015). IFN-γ also induced increases of 52, 71 and 96%, respectively, in response to the same stimuli (P<0.006). Also, the capacity of PMNs to damage hyphae as measured by the 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide colorimetric metabolic assay was significantly enhanced by G-CSF and IFN-γ (P<0.01 and <0.05, respectively). The enhancement was achieved irrespective of serum opsonization of the hyphae, indicating upregulatory actions of the 2 cytokines on signal pathways specific for opsonized and non-opsonized hyphae. The combination of the 2 cytokines exhibited an additive effect at the higher concn compared with the effects of the cytokines alone (P<0.05). Pretreatment of PMNs with protein synthesis inhibitors showed that IFN-γ activates PMN function through transcriptional regulation, whereas the effect of G-CSF does not require new proteins. It is suggested that G-CSF and IFN-γ have regulatory roles in host defence against Aspergillus hyphae, irrespective of serum opsonization, and a potential utility as adjuncts for prevention and possible treatment of invasive aspergillosis. KW - cytokines KW - immunology KW - neutrophils KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosoma japonicum-infected mice show reduced hepatic fibrosis and eosinophilia and selective inhibition of interleukin-5 secretion by CD4+ cells after treatment with anti-interleukin-2 antibodies. AU - Cheever, A. W. AU - Xu, Y. H. AU - Sher, A. AU - Finkelman, F. D. AU - Cox, T. M. AU - Macedonia, J. G. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 4 SP - 1288 EP - 1292 SN - 0019-9567 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806865. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2. Subject Subsets: Helminthology N2 - Schistosoma japonicum-infected mice (strain C3H/HeN) were injected with antibodies to interleukin-2 (IL-2) and/or IL-2 receptor to clarify the role of IL-2 on the granulomatous reaction around schistosome eggs in the liver. Granulomata were of normal or slightly increased size in animals subjected to IL-2 blockade, but hepatic fibrosis was markedly decreased in treated animals 10 weeks after infection. Anti-IL-2 treatment significantly decreased the in vitro secretion of IL-5 by antigen-stimulated spleen cells, and peripheral eosinophilia and tissue eosinophilia were diminished. Secretion of IL-2, IL-4, and gamma interferon was unaffected. The results indicate that IL-2 is not an essential determinant of granuloma size in S. japonicum-infected mice but that, as in Schistosoma mansoni infection, the development of hepatic fibrosis is critically dependent on IL-2 levels and granuloma size and hepatic fibrosis are differentially regulated. KW - Cytokines KW - Experimental infections KW - helminths KW - Human diseases KW - immune response KW - Interferon KW - Interleukin 2 KW - Interleukin 4 KW - Interleukin 5 KW - Interleukins KW - Laboratory animals KW - parasites KW - Digenea KW - mice KW - Muridae KW - Rodents KW - Schistosoma japonicum KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806865&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi. AU - Whitmire, W. M. AU - Garon, C. F. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 4 SP - 1460 EP - 1467 SN - 0019-9567 AD - Whitmire, W. M.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950503050. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 308067-57-4. Subject Subsets: Medical & Veterinary Entomology N2 - Lymphocyte blastogenesis assays and immunoblotting were used to investigate and compare murine B-cell responses to preparations of extracellular membrane blebs (BAg) and spirochaetes (Ag) of B. burgdorferi. Immunoblotting BAg, Ag and medium control preparations with serum from naive and infected C57BL/10 mice revealed that BAg and Ag had similar specific reactivity profiles except that major antigens of 83, 60 and 41 kDa were detected in Ag but not in BAg. It was determined that 1 µg (dry weight) of Ag contained 0.0051 and 0.0063 µg of outer surface proteins A (OspA) and OspB, respectively, whereas 1 µg (dry weight) of BAg contained 0.0024 µg of OspA and 0.0015 µg of OspB. Both BAg and Ag caused blastogenesis in cultures of spleen cells from both groups of mice, but BAg-stimulated lymphocytes exhibited significantly greater (P¬< 0.05) blastogenesis after 2 or 6 days of culture than did lymphocytes stimulated by Ag or medium control. Flow cytometry and antibody capture ELISAs identified responding lymphocytes as B cells which secreted polyclonal IgM but not IgG or IgA. Treatment of BAg and lipopolysaccharide controls with polymyxin B resulted in as much as 20.7 and 54.3% mean decreases in blastogenesis, respectively. Fractionation of BAg or Ag by ultracentrifugation before culture with spleen cells from naive mice indicated that B-cell blastogenesis was probably associated with spirochaetal membranes. The results demonstrated that specific humoral responses are directed towards extracellular membrane blebs which lack the 83-, 60- and 41-kDa antigens of intact spirochaetes and that blebs also possess significant nonspecific mitogenic activity for murine B cells. This activity was not due entirely to typical lipopolysaccharide or OspA and OspB lipoproteins. KW - antigens KW - B lymphocytes KW - IgM KW - immune response KW - immunoglobulins KW - laboratory animals KW - Lyme disease KW - Borrelia burgdorferi KW - mice KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - B cells KW - bacterium KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunogens KW - immunological reactions KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503050&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells. AU - Heinzen, R. A. AU - Hayes, S. F. AU - Peacock, M. G. AU - Hackstadt, T. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 5 SP - 1926 EP - 1935 SN - 0019-9567 AD - Heinzen, R. A.: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59830, USA. N1 - Accession Number: 19950503052. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9064-37-3. Subject Subsets: Medical & Veterinary Entomology N2 - Members of the spotted fever group (SFG) of rickettsiae spread rapidly from cell to cell by an unknown mechanism(s). Staining of R. rickettsii-infected Vero cells with rhodamine phalloidin demonstrated unique actin filaments associated with one pole of intracellular rickettsiae. F-actin tails >70 µm in length were seen extending from rickettsiae. Treatment of infected cells with chloramphenicol eliminated rickettsia-associated F-actin tails, suggesting that de novo protein synthesis of one or more rickettsial proteins is required for tail formation. Rickettsiae were coated with F-actin as early as 15 min postinfection, and tail formation was detected by 30 min. A survey of virulent and avirulent species within the SFG rickettsiae demonstrated that all formed actin tails entirely or exhibited only very short tails. Transmission electron microscopy demonstrated fibrillar material in close association with R. rickettsii but not R. prowazekii. Biochemical evidence that actin polymerization plays a role in movement was provided by showing that transit of R. rickettsii from infected cells into cell culture medium was inhibited by treatment of host cells with cytochalasin D. These data suggest that the cell-to-cell transmission of SFG rickettsiae may be aided by induction of actin polymerization in a fashion similar to that described for Shigella flexneri and Listeria monocytogenes. KW - actin KW - cells KW - fluorescence KW - infection KW - polymerization KW - Rickettsia australis KW - Rickettsia conorii KW - Rickettsia montanensis KW - Rickettsia parkeri KW - Rickettsia prowazekii KW - Rickettsia rickettsii KW - Rickettsia typhi KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - Rickettsia montana KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503052&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An approach to development of specific T-lymphocyte lines by use of preprocessed antigens in Plasmodium vinckei vinckei murine malaria. AU - Wasserman, G. M. AU - Kumar, S. AU - Ahlers, J. AU - Ramsdell, F. AU - Berzofsky, J. A. AU - Miller, L. H. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 5 SP - 1958 EP - 1963 SN - 0019-9567 AD - Wasserman, G. M.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930805899. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2. Subject Subsets: Protozoology N2 - The development of parasite-specific T-cell lines represents one approach to the potential identification of relevant immunogens in erythrocytic malarial infection. However, the use of parasitized-erythrocyte lysates as antigens inhibits the proliferation of T cells. To circumvent this problem, antigen-presenting cells (APCs) were pre-incubated from spleens of malaria-naive, BALB/c mice with a Plasmodium vinckei vinckei (ATCC 30091) (referred to as P. vinckei)-parasitized erythrocyte lysate. APCs were subsequently irradiated and washed prior to being incubated with T lymphocytes from P. vinckei-immune, histocompatible mice. After 8 to 10 cycles of antigenic stimulation and rest, 2 T-cell lines were analyzed. Both lines were predominantly CD4+. Proliferation assays demonstrated marked lymphocyte blastogenesis to syngeneic but not allogeneic APCs that had preprocessed malarial antigen. Antigen incubated directly with T cells and nonpulsed APCs in vitro did not result in T-cell proliferation. Assays of interleukin-2 (IL-2), IL-4, IL-5 and gamma interferon were compatible with one cell line being predominantly TH1 and the other being TH2. Thus, APCs that have preprocessed malarial antigen and are free of extraneous parasite material induce highly reactive, antigen-specific, major histocompatibility complex-restricted T-cell lines that functionally appear capable of inducing humoral and/or cell-mediated immunity. KW - antigens KW - Cytokines KW - Experimental infections KW - immune response KW - Interferon KW - Interleukin 2 KW - Interleukin 4 KW - Interleukin 5 KW - Laboratory animals KW - parasites KW - T lymphocytes KW - Apicomplexa KW - mice KW - Muridae KW - Plasmodiidae KW - Plasmodium vinckei KW - protozoa KW - Rodents KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930805899&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of expression of major outer surface proteins in Borrelia burgdorferi. AU - Margolis, N. AU - Rosa, P. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 5 SP - 2207 EP - 2210 SN - 0019-9567 AD - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950503055. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A B. burgdorferi clone (CA-11 2A) which does not synthesize the major outer surface proteins OspA and OspB was characterized. While the osp operon is intact and capable of expression, no mRNA transcript is detectable in this clone. These results suggest that osp operon expression in the B. burgdorferi clone can be regulated at the level of transcription. KW - clones KW - gene expression KW - molecular genetics KW - proteins KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variability of osp genes and gene products among species of Lyme disease spirochetes. AU - Marconi, R. T. AU - Konkel, M. E. AU - Garon, C. F. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 6 SP - 2611 EP - 2617 SN - 0019-9567 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. N1 - Accession Number: 19942025445. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - A comparison of the osp operon in 24 Lyme disease isolates, including representatives from each of the three established species, Borrelia burgdorferi, Borrelia garinii, and group VS461, was conducted. Several properties were assessed to determine whether the variability observed in this operon was reflective of the species of the isolate. At the transcriptional level, start site and Northern (RNA) blot analyses were conducted. B. garinii and VS461 group isolates were found to possess an untranslated leader sequence 6 nucleotides longer than that observed in B. burgdorferi isolates. By Northern blot analyses all Lyme disease isolates, except the B. garinii isolate VS102, were found to produce a polycistronic full-length ospAB message. Isolate VS102 produced a truncated message lacking the ospB portion of the transcript. Southern blot analyses suggest that the deletion occurred at the DNA level and was not due to a posttranscriptional event. Analysis of the outer surface proteins by two-dimensional gel electrophoresis demonstrated that the OspB isoelectric points were variable, with the OspB of B. garinii isolates exhibiting a pronounced acidic shift. The reactivity of different isolates to OspA and -B monoclonal antibodies and to a hyperimmune anti-ospAB serum was also variable. The results presented here demonstrate genotypic and phenotypic heterogeneity in the osp operon at both the inter- and intraspecies levels. The results have implications concerning the use of the osp genes or their gene products in the development of a Lyme disease vaccine, as diagnostic markers of Lyme disease, and in subtyping of Lyme disease isolates. AS<new para>ADDITIONAL ABSTRACT:<new para>A comparison of the osp operon in 24 Lyme disease isolates (from the USA, Europe and Japan), including representatives from Borrelia burgdorferi s.s, B. garinii and group VS461 [B. afzelii], was conducted. Several properties were assessed to determine whether the variability observed in this operon was reflective of the species of the isolate. At the transcriptional level, start site and Northern (RNA) blot analyses were conducted. B. garinii and VS461 group isolates were found to possess an untranslated leader sequence 6 nucleotides longer than that observed in B. burgdorferi isolates. By Northern blot analyses all Lyme disease isolates, except the B. garinii isolate VS102 (from Ixodes ricinus in Switzerland), were found to produce a polycistronic full-length ospAB message. Isolate VS102 produced a truncated message lacking the ospB portion of the transcript. Southern blot analyses suggest that the deletion by 2-dimensional gel electrophoresis demonstrated that the OspB isoelectric points were variable, with the OspB of B. garinii isolates exhibiting a pronounced acidic shift. The reactivity of different isolates to OspA and -B monoclonal antibodies and to a hyperimmune anti-ospAB serum was also variable. The results demonstrated genotypic and phenotypic heterogeneity in the osp operon at both the inter- and intraspecies levels. The results have implications concerning the use of the osp genes or their gene products in the development of a Lyme disease vaccine, as diagnostic markers of Lyme disease, and in subtyping of Lyme disease isolates. KW - aetiology KW - DNA KW - genes KW - genetic analysis KW - genetic variation KW - immunoblotting KW - Lyme disease KW - molecular genetics KW - Northern blotting KW - operons KW - proteins KW - taxonomy KW - Borrelia KW - Borrelia afzelii KW - Borrelia burgdorferi KW - Borrelia garinii KW - Spirochaetales KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - bacterium KW - biochemical genetics KW - causal agents KW - deoxyribonucleic acid KW - etiology KW - genetic variability KW - genospecies KW - genotypic variability KW - genotypic variation KW - lyme borreliosis KW - systematics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon. AU - Roilides, E. AU - Uhlig, K. AU - Venzon, D. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1993/// VL - 61 IS - 11 SP - 4870 EP - 4877 SN - 0019-9567 AD - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931251554. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The potential preventive utility of granulocyte colony-stimulating factor (G-CSF) and γ-interferon (IFN-γ) on the deleterious effect of corticosteroids on neutrophil (PMN) antifungal function was investigated. The effects of hydrocortisone (HCS) and dexamethasone (DXS) on PMN-induced damage of A. fumigatus hyphae were studied with or without pretreatment of PMNs with G-CSF and IFN-γ. PMNs treated with HCS (≥3000 μM) or DXS (≥10 μM) during a 2-h colorimetric tetrazolium metabolic assay showed suppressed percentage of hyphal damage (P<0.02). Both HCS (≥30 μM) and DXS (≥1 μM) significantly suppressed oxidative burst measured as superoxide anion release by PMNs in response to opsonized and non-opsonized hyphae as well as to N-formylmethionyl leucyl phenylalanine. Pretreatment of PMNs with G-CSF (4000 U/ml) and/or IFN-γ (100 and 1000 U/ml) for 90 min prevented the suppression of hyphal damage that occurred in the presence of HCS (3000 μM; P<0.01) or DXS (10 μM; P≤0.001). G-CSF (4000 U/ml) and IFN-γ (100 U/ml) combined had an additive effect on increasing the antifungal activity of HCS-treated but not of DXS-treated PMNs compared with IFN-γ alone (P=0.015). It is concluded that corticosteroids impair PMN function in response to A. fumigatus and that G-CSF and IFN-γ prevent this impairment. KW - cytokines KW - immunology KW - neutrophils KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Strain polymorphism of Plasmodium falciparum transmission-blocking target antigen Pfs230. AU - Williamson, K. C. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1993/// VL - 62 IS - 1 SP - 125 EP - 127 SN - 0166-6851 AD - Williamson, K. C.: Molecular Vaccine Section, Bldg. 4 Rm B1-37, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940801099. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The genomic sequence of Pfs230 from the 7G8 strain of Plasmodium falciparum (a chloroquine-resistant clone from a Brazilian isolate) was determined and compared to the cDNA sequence of the 3D7 strain (a chloroquine-sensitive clone from isolate NF54, thought to be of African origin). The complete Pfs230 open reading frame was continuous in the 7G8 genomic clones, indicating it is encoded by a single exon. The genomic structure of 3D7 appeared to be the same as 7G8 by restriction enzyme analysis. Also, introns were not found at the 5′ or 3′ end of the gene from 3D7, by PCR. The nucleotide sequences of 3D7 and 7G8 were 99.8% identical. There were 25 nucleotide differences in a total of 9417 nucleotides. The extent of polymorphism of Pfs230 was also studied in other isolates (CAMP, LF4 and LE5). KW - Antigens KW - genes KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - polymorphism KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - Transmission-blocking target antigen Pfs230 KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801099&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cohort study in southern China of tin miners exposed to radon and radon decay products. AU - Xuan, X. Z. AU - Lubin, J. H. AU - et al. AU - Li, J. Y. ( JO - Health Physics JF - Health Physics Y1 - 1993/// VL - 64 IS - 2 SP - 120 EP - 131 SN - 0017-9078 AD - Xuan, X. Z.: (J.H. Lubin) Biostatistics Branch, National Cancer Institute, EPN, Room 403, 6130 Executive Boulevard, Rockville, MD 20892, USA. N1 - Accession Number: 19932021620. Publication Type: Journal Article. Language: English. Registry Number: 10043-92-2, 7440-31-5. Subject Subsets: Public Health N2 - ... [The authors report a large] historical cohort study of male employees of the Yunnan Tin Corporation in southern China. The cohort consists of 17 143 workers with 175 143 person years of observation and 981 lung cancer events. Eighty percent of the workers were employed underground and exposed to radon. The excess relative risk increased linearly with exposure, rising 0.6% per working level month (95% confidence interval = 0.4-0.8). In the mines, workers were also exposed to arsenic-containing dusts. Adjustment for arsenic exposure, a known lung carcinogen, reduced the effect of radon exposure to 0.2% per working level month (95% confidence interval = 0.1-0.2). The excess relative risk/working level month declined significantly with attained age and with radon exposure rate as measured by the cumulative working level month divided by duration of exposure. It also declined significantly with years from last exposure and with time since exposure, but these declines were consistent only after adjustment for arsenic exposure. In this cohort, 41% of the underground workers were first exposed when <15 years old; however, lung cancer risk did not vary consistently with age at first radon exposure. A joint analysis of radon exposure and smoking status (smoker vs. nonsmoker) rejected both an additive and a multiplicative association; the relationship was consistent with an intermediate association. [Data on smoking were missing for 4088 subjects but there were very few non-smoking non-radon-exposed cases of lung cancer.] AS KW - exposure KW - miners KW - occupational medicine KW - occupations KW - radiation KW - radon KW - tin KW - workers KW - Asia KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - People's Republic of China KW - tin miners KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021620&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity. AU - Falgout, B. AU - Miller, R. H. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 4 SP - 2034 EP - 2042 SN - 0022-538X AD - Falgout, B.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950507531. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - Most proteolytic cleavages in the nonstructural protein (NS) region of the flavivirus polyprotein are effected by a virus-encoded protease composed of 2 viral proteins, NS2B and NS3. The N-terminal 180-amino-acid-region of NS3 includes sequences with homology to the active sites of serine proteases, and there is evidence that this portion of NS3 can mediate proteolytic cleavages. In contrast, nothing is known about required sequences in NS2B. A series of deletion mutations were constructed in the NS2B portion of plasmid pTM/NS2B-30%NS3 which expresses dengue virus type 4 (DEN4) cDNA encoding NS2B and the N-terminal 184 residues of NS3 from the T7 RNA polymerase promoter. Mutant or wild-type plasmids were transfected into cells which had been infected with a recombinant vaccinia virus expressing T7 RNA polymerase, and the protease activities of the expressed polyproteins were assayed by examining the extent of self-cleavage at the NS2B-NS3 junction. The results identified a 40-amino-acid segment of NS2B (DEN4 amino acids 1396 to 1435) essential for protease activity. A hydrophobicity profile of DEN4 NS2B predicts this segment constitutes a hydrophilic domain surrounded by hydrophobic regions. Hydrophobicity profiles of the NS2B proteins of other flaviviruses show similar patterns. Amino acid sequence alignment of this domain of DEN4 NS2B with comparable regions of other proteins of flaviviruses indicates significant sequence conservation, especially at the N-terminal end. These observations suggest that the central hydrophilic domain of NS2B of these other flaviviruses will also prove to be essential for protease activity. KW - amino acids KW - arboviruses KW - deletions KW - enzyme activity KW - nucleotide sequences KW - proteinases KW - viral proteins KW - dengue 4 virus KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - DNA sequences KW - nonstructural proteins KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant. AU - Novembre, F. J. AU - Johnson, P. R. AU - Lewis, M. G. AU - Anderson, D. C. AU - Klumpp, S. AU - McClure, H. M. AU - Hirsch, V. M. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 5 SP - 2466 EP - 2474 SN - 0022-538X AD - Novembre, F. J.: (V.M. Hirsch) Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. N1 - Accession Number: 19942051427. Publication Type: Journal Article. Language: English. KW - env gene KW - molecular biology KW - pathogenesis KW - pathogenicity KW - Macaca KW - simian immunodeficiency virus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051427&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The RRE of human immunodeficiency virus type 1 contributes to cell-type-specific viral tropism. AU - Dayton, E. T. AU - Konings, D. A. M. AU - Lim, S. Y. AU - Hsu, R. K. S. AU - Butini, L. AU - Pantaleo, G. AU - Dayton, A. I. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 5 SP - 2871 EP - 2878 SN - 0022-538X AD - Dayton, E. T.: (A.I. Dayton) National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051441. Publication Type: Journal Article. Language: English. KW - genomes KW - human immunodeficiency viruses KW - molecular biology KW - mutations KW - pathogenesis KW - Rev protein KW - tropisms KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051441&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression. AU - Kashanchi, F. AU - Duvall, J. F. AU - Lindholm, P. F. AU - Radonovich, M. F. AU - Brady, J. N. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 5 SP - 2894 EP - 2902 SN - 0022-538X AD - Kashanchi, F.: (J.N. Brady) Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051438. Publication Type: Journal Article. Language: English. KW - binding KW - gene expression KW - molecular biology KW - protein KW - transcription KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - DNA transcription KW - HTLV-BLV group KW - long terminal repeat KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051438&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice. AU - Pletnev, A. G. AU - Bray, M. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 8 SP - 4956 EP - 4963 SN - 0022-538X AD - Pletnev, A. G.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950507459. Publication Type: Journal Article. Language: English. Number of References: 28 ref. N2 - Two new chimeric flaviviruses were constructed from full-length cDNAs which contained tick-borne encephalitis virus (TBEV) capsid membrane envelope (CME) or membrane envelope (ME) structural protein genes and the remaining genes derived from dengue type 4 virus (DEN4). Studies involving mice inoculated intracerebrally with the ME chimeric virus indicated that it retained the neurovirulence of its TBEV parent from which its pre-M and E genes were derived. However, unlike parental TBEV, the chimeric virus did not produce encephalitis when mice were inoculated peripherally, indicating a loss of neuroinvasiveness. In the present study, the ME chimeric virus (vME) was subjected to mutational analysis in an attempt to reduce or ablate neurovirulence measured by direct inoculation of virus into the brain. 3 distinct mutations were identified each of which was associated independently with a significant reduction of mouse neurovirulence of vME. These mutations ablated (i) the TBEV pre-M cleavage site, (ii) the TBEV E glycosylation site, or (iii) the 1st DEN4 NS1 glycosylation site. In contrast, ablation of the 2nd DEN4 NS1 glycosylation site or the TBE pre-M glycosylation site or amino acid substitution at 2 positions in the TBEV E protein increased neurovirulence. The only conserved feature of the 3 attenuated mutants was restriction of virus yield in both simian and mosquito cells. Following parenteral inoculation, these attenuated mutants induced complete resistance in mice to fatal encephalitis caused by the highly neurovirulent vME. KW - arboviruses KW - genetics KW - laboratory animals KW - mutations KW - virulence KW - chimaera KW - dengue 4 virus KW - mice KW - Tick-borne encephalitis virus KW - Chimaeridae KW - Chimaeriformes KW - Chondrichthyes KW - fishes KW - vertebrates KW - Chordata KW - animals KW - aquatic organisms KW - aquatic animals KW - eukaryotes KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - arthropod-borne viruses KW - Central European encephalitis virus KW - glycosylation KW - tickborne encephalitis virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507459&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein. AU - Maldarelli, F. AU - Chen, M. Y. AU - Willey, R. L. AU - Strebel, K. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 8 SP - 5056 EP - 5061 SN - 0022-538X AD - Maldarelli, F.: Laboratory of Molecular Microbiology, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009829. Publication Type: Journal Article. Language: English. Number of References: 30 ref. N2 - The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotranslationally inserted into canine microsomal membranes. Proteolytic digestion and immunoprecipitation studies revealed that Vpu was a type I integral membrane protein, with the hydrophilic domain projecting from the cytoplasmic membrane face. In addition, several high-molecular-weight proteins containing Vpu were identified by chemical cross-linking. Such complexes also formed when wild-type Vpu and a Tat-Vpu fusion protein were coexpressed. Subsequent analysis by one- and two-dimensional electrophoresis revealed that these high-molecular-weight complexes consisted of homo-oligomers of Vpu. These findings indicate that Vpu is a type I integral membrane protein capable of multimerization. KW - human immunodeficiency viruses KW - proteins KW - surface proteins KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - membrane proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009829&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: Evidence for the involvement of transcription factor Ets1. AU - Dittmer, J. AU - Gitlin, S. D. AU - Reid, R. L. AU - Brady, J. N. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 10 SP - 6087 EP - 6095 SN - 0022-538X AD - Dittmer, J.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010516. Publication Type: Journal Article. Language: English. Number of References: 68 ref. N2 - Expression of the parathyroid hormone-related protein (PTHrP), a protein that plays a primary role in the development of the humoral hypercalcaemia of malignancy, is regulated by two distinct promoters, P1 and P2. PTHrP is overexpressed in lymphocytes from adult T-cell leukemia patients. The authors now demonstrate that in the human T-cell lymphotropic virus type I-transformed cell line MT-2, RNA synthesis is initiated primarily at the P2 promoter. Furthermore, in cotransfection experiments, Tax1 transactivates the P2 promoter 10- to 12-fold. By using deletion and site-specific point mutations, the authors have identified a promoter-proximal sequence (positions -72 to -40) which is important for Tax1 transactivation. The PTHrP promoter-proximal element contains two potential overlapping Ets1 binding sites, EBS I and EBS II. Gel shift analysis demonstrated that Ets1 binds specifically to both EBS I and EBS II. Mutation of the consensus GGAA core motif in EBS I abolished binding and Tax1 transactivation in Jurkat T lymphocytes. In Ets1-deficient cells, cotransfection of Tax1 and Ets1 expression plasmids stimulates PTHrP promoter activity. In the absence of Ets1, minimal transactivation of the PTHrP promoter is observed. These data suggest that Ets1 binds to EBS I and cooperates with Tax1 to transactivate the PTHrP P2 promoter. KW - infections KW - parathyroid KW - promoters KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - HTLV-BLV group KW - parathyroid gland KW - promoter region KW - promoter sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010516&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. AU - Jeang, K. T. AU - Chun, R. AU - Lin, N. H. AU - Gatignol, A. AU - Glabe, C. G. AU - Fan, H. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 10 SP - 6224 EP - 6233 SN - 0022-538X AD - Jeang, K. T.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010520. Publication Type: Journal Article. Language: English. Number of References: 75 ref. N2 - Recent genetic experiments have suggested that tat transactivation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat requires functional upstream enhancer sequences-Sp1 sites, in particular. In these experiments, HeLa cell nuclear extracts were passed over affinity matrices containing chemically synthesized or bacterially expressed HIV-1 Tat. Assay of material that bound to and eluted from the Tat matrices revealed the presence of the Sp1 transcription factor. Other transcription factors (Oct and NF-κB) also bound to Tat matrices but with less efficiency - in parallel with the lower capacities of these binding motifs to confer Tat responsiveness on a basal HIV-1 promoter compared with Sp1 sites. Passage of nuclear extracts over matrices containing other neutral proteins, including bovine serum albumin, ovalbumin, and lysozyme, revealed no or reduced binding. Cross-linking experiments indicated that the purified Sp1 and Tat proteins can form multimeric complexes in the absence of other proteins. The region of Tat responsible for Sp1 binding was localized to a region encompassing residues 30 to 62. Immunoprecipitation experiments with HIV-1-infected T lymphocytes indicated coimmunoprecipitation of Tat and Sp1. These experiments extend previous genetic experiments and suggest a direct interaction between Tat and Sp1 during transactivation. KW - in vitro KW - infections KW - proteins KW - transcription KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA transcription KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. AU - Purcell, D. F. J. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 11 SP - 6365 EP - 6378 SN - 0022-538X AD - Purcell, D. F. J.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009967. Publication Type: Journal Article. Language: English. Number of References: 59 ref. KW - human immunodeficiency viruses KW - infectivity KW - messenger rna KW - proteins KW - replication KW - viral diseases KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - mRNA KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009967&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic determinants of dengue type 4 virus neurovirulence for mice. AU - Kawano, H. AU - Rostapshov, V. AU - Rosen, L. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 11 SP - 6567 EP - 6575 SN - 0022-538X AD - Kawano, H.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950507462. Publication Type: Journal Article. Language: English. Number of References: 30 ref. N2 - Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses which contained the 3 structural protein genes from the parental virus or the neurovirulent mutant in the background sequence of nonneurovirulent DEN4 strain 814669. The chimera which contained the 3 structural protein genes from mouse neurovirulent DEN4 strain H241 proved to be highly neurovirulent in mice, whereas the chimera which contained the corresponding genes from its non-mouse-adapted parent was not neurovirulent. This finding indicates that most of the genetic loci for the neurovirulence of the DEN4 mutant lie within the structural protein genes. A comparison of the amino acid sequences of the parent and its mouse neurovirulent mutant proteins revealed that there were only 5 amino acid differences in the structural protein region, and 3 of these were located in the envelope (E) glycoprotein. Analysis of chimeras which contained 1 or 2 of the variant amino acids of the mutant E sequence substituting for the corresponding sequence of the parental virus identified 2 of these amino acid changes as important determinants of mouse neurovirulence. First, the single substitution of Ile for Thr-155 which ablated 1 of the 2 conserved glycosylation sites in parental E yielded a virus which was almost as neurovirulent as the mouse-adapted mutant. Thus, the loss of an E glycosylation site appears to play a role in DEN4 neurovirulence. Second, the substitution of Leu for Phe-401 also yielded a neurovirulent virus, but it was less neurovirulent than the glycosylation mutant. These findings indicate that at least 2 of the genetic loci responsible for DEN4 mouse neurovirulence map within the structural protein genes. KW - amino acid sequences KW - amino acids KW - arboviruses KW - genetics KW - laboratory animals KW - virulence KW - dengue 4 virus KW - mice KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507462&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element. AU - Li, G. AU - Lisziewicz, J. AU - Sun, D. AU - Zon, G. AU - Daefler, S. AU - Wong-Staal, F. AU - Gallo, R. C. AU - Klotman, M. E. JO - Journal of Virology JF - Journal of Virology Y1 - 1993/// VL - 67 IS - 11 SP - 6882 EP - 6888 SN - 0022-538X AD - Li, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009974. Publication Type: Journal Article. Language: English. Number of References: 73 ref. N2 - The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. The authors demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy. KW - analogues KW - human diseases KW - human immunodeficiency viruses KW - replication KW - rev protein KW - viral diseases KW - viral regulatory proteins KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of epilepsy in developing countries. AU - Senanayake, N. AU - Román, G. C. JO - Bulletin of the World Health Organization JF - Bulletin of the World Health Organization Y1 - 1993/// VL - 71 IS - 2 SP - 247 EP - 258 SN - 0042-9686 AD - Senanayake, N.: Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940800920. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 93 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - This article reviews the epidemiology of epilepsy in developing countries in terms of its incidence, prevalence, seizure type, mortality data, and aetiology. The prevalence of epilepsy is particularly high in Latin America, Liberia, Nigeria and Tanzania. Parasitic infections, particularly neurocysticercosis, are important aetiological factors in the pathogenesis of epilepsy in many of these countries. Other factors include intracranial infections, perinatal brain damage, head injuries, and toxic agents. KW - brain KW - epidemiology KW - epilepsy KW - geographical distribution KW - helminths KW - human diseases KW - metacestodes KW - neurocysticercosis KW - parasites KW - reviews KW - Developing countries KW - Cestoda KW - man KW - Taenia solium KW - Taeniidae KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - countries KW - cerebrum KW - parasitic worms KW - pork tapeworm KW - prevalence KW - Third World KW - Underdeveloped Countries KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800920&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of the murine model of schistosomal hepatic periportal fibrosis ("pipestem" fibrosis). AU - Andrade, Z. A. AU - Cheever, A. W. JO - International Journal of Experimental Pathology JF - International Journal of Experimental Pathology Y1 - 1993/// VL - 74 IS - 2 SP - 195 EP - 202 SN - 0959-9673 AD - Andrade, Z. A.: (A.W. Cheever) Laboratory of Parasitic Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020954. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of normal-looking hepatic parenchyma, a picture mimicking 'clay pipestem fibrosis' seen in human patients with advanced schistosomiasis. The model was reproduced in outbred and in several strains of inbred mice, and their main characteristics were studied and compared to the human counterpart. A balanced consideration of the similarities and differences between the murine model and human pipestem fibrosis is needed for the adequate utilization of this simple, reproducible and inexpensive experimental model. AS KW - Schistosomiasis KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bilharzia KW - bilharziasis KW - hepatic periportal fibrosis KW - schistosomosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro culture of the mosquito stages of Plasmodium falciparum. AU - Warburg, A. AU - Schneider, I. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1993/// VL - 76 IS - 2 SP - 121 EP - 126 SN - 0014-4894 AD - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804184. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases N2 - The sporogonic cycle of P. falciparum was obtained in vitro. Mature gametocytes, from blood-stage cultures, produced gametes that underwent fertilization at elevated pH and ambient temperatures. Wheat germ agglutinin stimulated transformation of zygotes into retorts and ookinetes. 24 h thereafter, 18-49% mature ookinetes and 10-20% intermediate retort forms were counted. Cultures were seeded onto a basement membrane-like gel (Matrigel) in coculture with Drosophila melanogaster cells. Both ookinetes and retorts attached to Matrigel and transformed into oocysts. Mature oocysts and sporozoites expressed circumsporozoite protein.\From AS<new para>ADDITIONAL ABSTRACT:<new para>The sporogonic cycle of P. falciparum was obtained in vitro. Mature gametocytes, from blood-stage cultures, produced gametes that underwent fertilization at elevated pH and ambient temperatures. Wheat germ agglutinin stimulated transformation of zygotes into retorts and ookinetes. 24 h thereafter, 18-49% mature ookinetes and 10-20% intermediate retort forms were counted. Cultures were seeded onto a basement membrane-like gel (Matrigel) in coculture with Drosophila melanogaster cells. Both ookinetes and retorts attached to Matrigel and transformed into oocysts. Mature oocysts and sporozoites expressed circumsporozoite protein. KW - culture techniques KW - Developmental stages KW - Human diseases KW - malaria KW - Oocysts KW - Ookinetes KW - parasites KW - sporogony KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - falciparum malaria KW - growth phase KW - mosquito stages KW - mosquitoes KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804184&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Normal dexamethasone suppression in obese binge and nonbinge eaters with rapid weight loss. AU - Yanovski, S. Z. AU - Yanovski, J. A. AU - Gwirtsman, H. E. AU - Bernat, A. AU - Gold, P. W. AU - Chrousos, G. P. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1993/// VL - 76 IS - 3 SP - 675 EP - 679 SN - 0021-972X AD - Yanovski, S. Z.: Clinical Neuroendocrinology Branch, National Institutes of Health, Building 10, 3S231, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941403813. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 1879-72-7, 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1, 1926-94-9, 2265-67-7, 312-93-6, 50-02-2, 55812-90-3, 7743-96-6, 2392-39-4, 16978-57-7. Subject Subsets: Human Nutrition N2 - To evaluate whether rapid weight loss per se or some other aspect of starvation induces disruption of the hypothalamic-pituitary-adrenal (HPA) axis, 2 categories of obese women (body mass index >30 kg/m2) undergoing rapid weight loss were investigated: bulimics (n=12) and nonbinge eaters (n=8). Psychometric evaluation and overnight dexamethasone (1 mg) suppression tests were performed in obese as well as 12 race- and age-matched normal-weight women. Obese women were tested before and after 12 weeks of a liquid formula diet (800 kcal/day) and lost an average of 19.3 kg, which represented 17.3% of total body weight. Bulimics who were initially more depressed than nonbinge eaters or normal-weight controls, had a significant amelioration of their symptoms with weight loss. Neither group had evidence of disruption of the HPA axis before or after weight loss. Thus, rate of failure to suppress cortisol after dexamethasone was about 10% in obese and control groups and did not differ between pre- and postweight loss condition or between binge and nonbinge eaters. Serum free thyroxine was unchanged, whereas triiodothyronine decreased significantly with weight loss. It is concluded that weight loss may improve affect in the obese without altering HPA axis activity and it is suggested that one of the concomitants of restricted energy intake, perhaps in combination with a threshold body weight, may be of greater importance in causing abnormalities of dexamethasone suppression testing than rapid weight loss per se. KW - appetite disorders KW - bulimia KW - dexamethasone KW - hydrocortisone KW - obesity KW - weight reduction KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - binge eating KW - bulimia nervosa KW - cortisol KW - eating disorders KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403813&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Absence of triglyceride accumulation in lipoprotein lipase-deficient human monocyte-macrophages incubated with human very low density lipoprotein. AU - Skarlatos, S. I. AU - Dichek, H. L. AU - Fojo, S. S. AU - Brewer, H. B. AU - Kruth, H. S. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1993/// VL - 76 IS - 3 SP - 793 EP - 796 SN - 0021-972X AD - Skarlatos, S. I.: Section of Experimental Atherosclerosis, Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941403814. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 57-88-5, 9004-02-8. Subject Subsets: Human Nutrition N2 - The role of lipoprotein lipase in mediating uptake of normal VLDL triacylglycerols into human cultured monocyte-derived macrophages was studied using macrophage cells from a functionally lipoprotein lipase-deficient patient (a 36-years-old woman) and macrophages of cells from a normal subject (a 25-years-old man). After incubation with VLDL, massive accumulation of phase refractile (lipid) inclusions were noted by phase contrast microscopy within the normal, but not within the lipoprotein lipase-deficient macrophages. Chemical determinations of intracellular lipid confirmed massive triacylglycerol accumulation within normal but not in lipoprotein lipase-deficient macrophages. VLDL-derived cholesterol did not accumulate in either cell. Results confirm an additional role of lipoprotein lipase, that of mediating triacylglycerol accumulation into macrophages from normal human VLDL. Human monocyte-macrophages genetically deficient in a functional lipoprotein lipase will be useful to evaluate the role of lipoprotein lipase in macrophage accumulation of lipid from other forms of triacylglycerol-carrying lipoproteins, including hypertriglyceridaemic VLDL, β-VLDL and chylomicrons. KW - cell cultures KW - cholesterol KW - deficiency KW - lipoprotein lipase KW - macrophages KW - triacylglycerols KW - very low density lipoprotein KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diacylglycerol lipase KW - triglycerides KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403814&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmania: immunochemical comparison of the secretory (extracellular) acid phosphatases from various species. AU - Doyle, P. S. AU - Dwyer, D. M. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1993/// VL - 77 IS - 4 SP - 435 EP - 444 SN - 0014-4894 AD - Doyle, P. S.: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940801369. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9001-77-8. Subject Subsets: Protozoology; Tropical Diseases N2 - The soluble acid phosphatases (SAcP(s)) from various Leishmania species were compared immunochemically using both a monospecific rabbit antiserum and several MAbs made against the purified promastigotes SAcP of a cloned line of Leishmania donovani donovani. Results obtained from antibody-bridged enzyme activity assays demonstrated that these reagents quantitatively immunoprecipitated the enzymatic activities of SAcP(s) from 18 different W.H.O. reference stocks of Leishmania, including 2 L. major strains. These results showed, for the first time, that all SAcP(s) possessed some common cross-reactive antigenic epitopes. Immunoprecipitates obtained from [35S]methionine, metabolically labelled promastigote culture supernatants of the various species, were analyzed by SDS-PAGE/fluorography. These analyses showed that marked differences existed among the SAcP(s) both in their relative mobilities and the number of constituent bands resolved. Tunicamycin treatment resulted in a significant reduction in the apparent MWs of SAcP(s) from 3 different isolates, confirming the presence of N-linked carbohydrate side chains in these enzymes. In addition, the SAcP released by L. donovani intracellular amastigotes was also immunoprecipitated with the monospecific rabbit antisera from the culture supernatant of infected macrophages. It is concluded that despite individual species variations, the SacP(s) from all Leishmania tested have retained certain common antigenic/structural epitopes and functional protein domains. Such conservation among SAcP(s) suggests that this enzyme must play an essential role in the survival of promastigotes and amastigotes of all Leishmania species. KW - acid phosphatase KW - antigens KW - biochemistry KW - enzymes KW - epitopes KW - human diseases KW - immunochemistry KW - parasites KW - Leishmania KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - acid phosphatases KW - acid phosphomonoesterase KW - antigenic determinants KW - antigenicity KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801369&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Entamoeba histolytica: a method for isolate identification. AU - Clark, C. G. AU - Diamond, L. S. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1993/// VL - 77 IS - 4 SP - 450 EP - 455 SN - 0014-4894 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940801371. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A method to identify individual isolates of Entamoeba histolytica was developed, based on the discovery of extensive polymorphism in 2 Ent. histolytica genes, the serine-rich antigen gene and the "strain specific gene", each of which has an internal tandemly repeated structure. Using the polymerase chain reaction both size and restriction site polymorphisms were detected in the repetitive regions. When the 2 genes were used in combination 16 distinct DNA patterns were obtained out of 18 isolates examined. Moreover, these patterns were stable under a variety of conditions: long-term culture, axenization, cell cloning, and animal passage.From AS<new para>ADDITIONAL ABSTRACT:<new para>A method to identify individual isolates of Entamoeba histolytica was developed, based on the discovery of extensive polymorphism in 2 E. histolytica genes, the serine-rich antigen gene and the "strain specific gene", each of which has an internal tandemly repeated structure. Using the polymerase chain reaction both size and restriction site polymorphisms were detected in the repetitive regions. When the 2 genes were used in combination 16 distinct DNA patterns were obtained out of 18 isolates examined. Moreover, these patterns were stable under a variety of conditions: long-term culture, axenization, cell cloning, and animal passage. KW - chemotaxonomy KW - genes KW - human diseases KW - Identification KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - techniques KW - Endamoebidae KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Endamoebidae KW - biochemical genetics KW - biochemical taxonomy KW - Isolates KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Techniques and Methodology (ZZ900) KW - Taxonomy and Evolution (ZZ380) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Entamoeba histolytica: an explanation for the reported conversion of "nonpathogenic" amebae to the "pathogenic" form. AU - Clark, C. G. AU - Diamond, L. S. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1993/// VL - 77 IS - 4 SP - 456 EP - 460 SN - 0014-4894 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940801372. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The reported conversion of "nonpathogenic" Entamoeba histolytica isolates to the "pathogenic" form during attempted axenization of the amoebae was investigated with regard to the possibility of contamination of nonpathogenic cultures with pathogenic amoebae. To investigate this possibility a method was used based on analysis of stable DNA polymorphisms that allows the positive identification of individual pathogenic isolates. The DNA patterns obtained using the "converted" amoebae proved to be identical to those of reference isolates present in the laboratories at the time of conversion. It was also found that very few cells needed to be transferred for a pathogenic contaminant to become established in a nonpathogenic culture. It is concluded that cross-contamination fully explains the conversion phenomenon and thus recognition of nonpathogenic and pathogenic amebae as the distinct species Ent. dispar and Ent. histolytica, respectively, is upheld.From AS<new para>ADDITIONAL ABSTRACT:<new para>The reported conversion of "nonpathogenic" Entamoeba histolytica isolates to the "pathogenic" form during attempted axenization of the amoebae was investigated with regard to the possibility of contamination of nonpathogenic cultures with pathogenic amoebae. To investigate this possibility a method was used based on analysis of stable DNA polymorphisms that allows the positive identification of individual pathogenic isolates. The DNA patterns obtained using the "converted" amoebae proved to be identical to those of reference isolates present in the laboratories at the time of conversion. It was also found that very few cells needed to be transferred for a pathogenic contaminant to become established in a nonpathogenic culture. It is concluded that cross-contamination fully explains the conversion phenomenon and thus recognition of nonpathogenic and pathogenic amebae as the distinct species E. dispar and E. histolytica, respectively, is upheld. KW - conversion KW - human diseases KW - parasites KW - Pathogenicity KW - Endamoebidae KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Endamoebidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801372&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet as risk and therapy for cancer. AU - Clifford, C. AU - Kramer, B. JO - Medical Clinics of North America JF - Medical Clinics of North America Y1 - 1993/// VL - 77 IS - 4 SP - 725 EP - 744 SN - 0025-7125 AD - Clifford, C.: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19941401093. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition N2 - A brief overview of the scientific rationale for dietary guidelines that may reduce the risk of some types of cancers, breast, colon, and prostate in particular, is presented. Dietary modification clinical trials currently sponsored by the National Cancer Institute (USA) are described. Other topics include the role of total parenteral nutrition in cancer therapy and low-fat dietary interventions as an adjunct to breast cancer treatment. KW - carcinoma KW - colon KW - diet KW - diet treatment KW - mammary gland neoplasms KW - parenteral feeding KW - prostate KW - reviews KW - risk KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diet prescription KW - mammary tumour KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401093&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intraspecific diversity in the response of Trypanosoma cruzi to environmental stress. AU - Nozaki, T. AU - Dvorak, J. A. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1993/// VL - 79 IS - 3 SP - 451 EP - 454 SN - 0022-3395 AD - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 138, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806350. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology N2 - Epimastigotes of 5 Trypanosoma cruzi stocks were cultivated in liver infusion tryptose (LIT) medium at 23-25°C or cocultivated with vertebrate cells at 35°C. A temperature decrease from 26 to 23°C resulted in a stable 60% increase in population doubling time. In zymodeme I and II stocks, a temperature increase to 35°C resulted in a transient ~25% increase in doubling time during the first month followed by a ~30% decrease after 2 months. A zymodeme III stock did not grow at 35°C. Flow cytometric analyses showed that the total DNA/cell, guanine + cytosine (G-C), and adenine + thymidine content of 2 zymodeme II stocks increased by 3-11% when cultivated in LIT at 35°C, whereas the DNA values of 2 zymodeme I stocks did not change. The increased DNA levels, due predominantly to an increased kinetoplast G-C content, returned to normal levels when the culture temperature was reduced to 26°C. The effects of cocultivation with vertebrate cells at 35°C were identical to cultivation in LIT at 35°C except that the DNA increase in a zymodeme II stock was not stable. Total DNA/cell, nuclear, and kinetoplast DNA decreased by 8-13% upon prolonged cocultivation. No change in total protein, antigen profiles, complement sensitivity, or heat shock protein gene expression was observed as a consequence of culturing the parasites above 26°C. KW - chemotaxonomy KW - Culture techniques KW - DNA KW - heat shock KW - Heat stress KW - Human diseases KW - molecular genetics KW - parasites KW - Physiology KW - Temperature KW - Zymodemes KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - biochemical genetics KW - biochemical taxonomy KW - deoxyribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Taxonomy and Evolution (ZZ380) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806350&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular biology studies of tubercidin resistance in Trypanosoma cruzi. AU - Nozaki, T. AU - Dvorak, J. A. JO - Parasitology Research JF - Parasitology Research Y1 - 1993/// VL - 79 IS - 6 SP - 451 EP - 455 SN - 0044-3255 AD - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940800270. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A Trypanosoma cruzi stock (Sylvio-X10/7) was mutagenized and selected for resistance to high levels of tubercidin (TUB), a purine analogue. The TUB-resistant stocks were >100 times more resistant to TUB than was the parental stock. TUB and uridine transport in the TUB-resistant stocks decreased by 50%-90%, whereas thymidine and adenosine transport were unaffected. The data imply that TUB-resistant stocks have defects in the pathways involved in the transport of TUB and uridine but not in the thymidine and adenosine transport pathways. Karyotype analyses using specific probes showed that the deletion of a 950-kb chromosome-size DNA occurred in both of the TUB-resistant stocks. The data suggest that genes involved in nucleoside transport are located in this DNA region.From AS<new para>ADDITIONAL ABSTRACT:<new para>A Trypanosoma cruzi stock (Sylvio-X10/7) was mutagenized and selected for resistance to high levels of tubercidin (TUB), a purine analogue. The TUB-resistant stocks were >100 times more resistant to TUB than was the parental stock. TUB and uridine transport in the TUB-resistant stocks decreased by 50%-90%, whereas thymidine and adenosine transport were unaffected. The data imply that TUB-resistant stocks have defects in the pathways involved in the transport of TUB and uridine but not in the thymidine and adenosine transport pathways. Karyotype analyses using specific probes showed that the deletion of a 950-kb chromosome-size DNA occurred in both of the TUB-resistant stocks. The data suggest that genes involved in nucleoside transport are located in this DNA region. KW - biochemistry KW - human diseases KW - Molecular biology KW - nucleosides KW - parasites KW - purines KW - Resistance KW - uptake KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - purine bases KW - tubercidin KW - Pesticide and Drug Resistance (HH410) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The risk of measles, mumps, and varicella among young adults: a serosurvey of US Navy and Marine Corps recruits. AU - Struewing, J. P. AU - Hyams, K. C. AU - Tueller, J. E. AU - Gray, G. C. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1993/// VL - 83 IS - 12 SP - 1717 EP - 1720 SN - 0090-0036 AD - Struewing, J. P.: National Institutes of Health, Genetic Epidemiology Branch, Bldg EPN-439, Bethesda, MD 20892-9903, USA. N1 - Accession Number: 19942050298. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - To assess the risk of epidemic transmission and to guide immunization policy, the seroprevalence of antibody to measles, mumps, and varicella was determined in a group of young adults. A cross-sectional study of 1533 US Navy and Marine Corps recruits was conducted in June 1989. Antibody status was determined with commercially available enzyme-linked immunosorbent assays. Direct sex and race adjustment to the 15- to 29-year-old US population resulted in seronegativity rates of 17.8% for measles, 12.3% for mumps, and 6.7% for varicella. Measles and mumps seronegativity rates were higher among Whites whereas varicella seronegativity was higher among non-Whites. Recruits enlisting from outside the 50 US states, especially those from island territories, were more likely to lack varicella antibody. The sensitivity of a positive history of vaccination or disease in predicting antibody status was less than 90% for all diseases. These results suggested a continued potential for epidemics, especially of measles, and the need for mandatory immunization policies. Immigrants to the United States, especially those from island territories, may be a high-risk group that could benefit from varicella vaccination. AS KW - antibodies KW - Measles KW - military personnel KW - Mumps KW - Varicella KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - chicken pox KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050298&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer in the elderly: meeting the challenge of an aging population. AU - Monfardini, S. AU - Yancik, R. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 7 SP - 532 EP - 538 SN - 0027-8874 AD - Monfardini, S.: (R. Yancik) National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg. 31, Rm. 5C05, Bethesda, MD 20892, USA. N1 - Accession Number: 19942027667. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health N2 - This commentary focuses on cancer in the elderly, particularly in the United States and Italy. Cancer incidence, cancer mortality, aging of the population, slow accumulation of treatment information, and future research on aging and cancer are discussed. KW - elderly KW - Neoplasms KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - aged KW - cancers KW - elderly people KW - older adults KW - senior citizens KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027667&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. AU - Reichman, M. E. AU - Judd, J. T. AU - Longcope, C. AU - Schatzkin, A. AU - Clevidence, B. A. AU - Nair, P. P. AU - Campbell, W. S. AU - Taylor, P. R. AU - Longnecker, M. P. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 9 SP - 722 EP - 727 SN - 0027-8874 AD - Reichman, M. E.: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19941409493. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition; Public Health N2 - A study was examined to investigate the hypothesis that alcohol consumption affects values of reproductive hormones. 34 premenopausal women 21-40 years old were studied for 6 consecutive menstrual cycles and consumed ethanol 30 g (equivalent to about 2 average drinks) daily for 3 menstrual cycles and then no alcohol for the next 3 months. Energy intake was monitored to ensure that each woman would maintain body weight at about baseline level. Hormone assays were performed on pooled plasma or 24-h urine collected during follicular days (days 5-7), peri-ovulatory (days 12-15) and mid-luteal (days 21-23) phases of the third menstrual cycle for subjects on each diet. Results showed that alcohol consumption was was associated with significant increases in values of several hormones. Plasma dehydroepiandrosterone sulfate values were 7.0% higher in the follicular phase (P=0.05). In the peri-ovulatory phase, there were increases of 21.2% (P=0.01) in plasma estrone values, 27.5% (P=0.01) in plasma estradiol and 31.9% (P=0.009) in urinary estradiol values. In the luteal phase, urinary estrone values increased 15.2% (P=0.05), estradiol 21.6% (P=0.02) and estriol 29.1% (P=0.03). No changes were found in the percent of bioavailable estradiol, defined by the sum of percent free estradiol and percent albumin-bound estradiol. Increased total estradiol values in the peri-ovulatory phase suggest elevated absolute amounts of bioavailable estradiol. Increases in total estrogen values and amount of available estrogens in association with ethanol consumption in premenopausal women was shown.<new para>ADDITIONAL ABSTRACT:<new para>In this study of 34 premenopausal women aged 21-40 years [in Maryland, USA], the authors examine the hypothesis that alcohol consumption affects levels of reproductive hormones-a possible explanatory mechanism for a positive association between alcohol consumption and breast cancer risk. The study showed increases in total oestrogen levels and amount of bioavailable oestrogens in association with alcohol. The authors conclude that these results merit further investigation. M.P. Longnecker discusses the hormonal link between alcohol and breast cancer in an editorial on p692 of this issue. Louise M. Acres KW - alcohol intake KW - alcoholic beverages KW - blood KW - breast KW - breast cancer KW - ethanol KW - intake KW - menstrual cycle KW - neoplasms KW - oestrogens KW - risk KW - urine KW - women KW - Maryland KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - alcohol consumption KW - breasts KW - cancer sites KW - cancers KW - estrogens KW - ethyl alcohol KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Women (UU500) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409493&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. AU - Schiffman, M. H. AU - Bauer, H. M. AU - et al. AU - Hoover, R. N. ( JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 12 SP - 958 EP - 964 SN - 0027-8874 AD - Schiffman, M. H.: National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19942027740. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors studied 500 women with cervical intraepithelial neoplasia (CIN) and 500 control subjects receiving cytologic screening at Kaiser Permanente, a large prepaid health plan, in Portland, Oregon, USA. The established epidemiologic risk factors for CIN were assessed by telephone interview. They performed HPV testing of cervicovaginal lavage specimens by gene amplification using polymerase chain reaction with a consensus primer to target the L1 gene region of HPV. Unconditional logistic regression analysis was used to estimate relative risk of CIN and to adjust the epidemiologic associations for HPV test results to demonstrate whether the associations were mediated by HPV. The case subjects demonstrated the typical epidemiologic profile of CIN: they had more sex partners, more cigarette smoking, earlier ages at first sexual intercourse, and lower socioeconomic status. Statistical adjustment for HPV infection substantially reduced the size of each of these case-control differences. Seventy-six percent of cases could be attributed to HPV infection; the results of cytologic review suggested that the true percentage was even higher. Once HPV infection was taken into account, an association of parity with risk of CIN was observed in both HPV-negative and HPV-positive women. The data show that the great majority of all grades of CIN can be attributed to HPV infection, particularly with the cancer-associated types of HPV. In light of this conclusion, the investigation of the natural history of HPV has preventive as well as etiologic importance. [In an editorial on p 934 of this issue N.B. Kiviat and L.A. Koulsky discuss the implications for current views and treatment.]From AS KW - cervical cancer KW - cervix KW - epidemiology KW - infections KW - neoplasms KW - North America KW - Oregon KW - USA KW - human papillomaviruses KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - America KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Papillomaviridae KW - cancer sites KW - cancers KW - human papillomavirus KW - Papovaviridae KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027740&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality from second tumors among long-term survivors of retinoblastoma. AU - Eng, C. AU - Li, F. P. AU - et al. AU - Abramson, D. H. ( AU - Boice, J. D. Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 14 SP - 1121 EP - 1128 SN - 0027-8874 AD - Eng, C.: (J.D. Boice, Jr) Radiation Epidemiology Branch, National Cancer Institute, EPN 408, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19942027282. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - "A retrospective cohort study examined mortality among 1603 patients enrolled at 1 year after diagnosis of retinoblastoma during the period 1914-1984." KW - children KW - eyes KW - mortality KW - neoplasms KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - death rate KW - second tumours KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027282&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population. AU - Blot, W. J. AU - Li, J. Y. AU - et al. AU - Taylor, P. R. ( JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 18 SP - 1483 EP - 1492 SN - 0027-8874 AD - Blot, W. J.: Biostatistics Branch, Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19942027313. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - Individuals of ages 40-69 were recruited in 1985 from four Linxian communes in China. Mortality and cancer incidence during March 1986-May 1991 were ascertained for 29 584 adults who received daily vitamin and mineral supplementation throughout this period. The subjects were randomly assigned to intervention groups according to a one-half replicate of a 24 factorial experimental design. This design enabled testing for the effects of four combinations of nutrients: (A) retinol and zinc; (B) riboflavin and niacin; (C) vitamin C and molybdenum; and (D) beta carotene, vitamin E, and selenium. Doses ranged from one to two times US Recommended Daily Allowances. A total of 2127 deaths occurred among trial participants during the intervention period. Cancer was the leading cause of death, with 32% of all deaths due to oesophageal or stomach cancer, followed by cerebrovascular disease (25%). Significantly (P = 0.03) lower total mortality (relative risk [RR] = 0.91; 95% confidence interval [CI] = 0.84-0.99) occurred among those receiving supplementation with beta carotene, vitamin E, and selenium. The reduction was mainly due to lower cancer rates (RR = 0.87; 95% CI = 0.75-1.00), especially stomach cancer (RR = 0.79; 95% CI = 0.64-0.99), with the reduced risk beginning to arise about 1-2 years after the start of supplementation with these vitamins and minerals. No significant effects on mortality rates from all causes were found for supplementation with retinol and zinc, riboflavin and niacin, or vitamin C and molybdenum. Patterns of cancer incidence, on the basis of 1298 cases, generally resembled those for cancer mortality. The authors' findings indicate that vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population. From AS KW - epidemiology KW - neoplasms KW - oesophagus KW - stomach KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - esophagus KW - nutrition intervention KW - People's Republic of China KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. AU - Li, J. Y. AU - Taylor, P. R. AU - et al. AU - Li, B. ( JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 18 SP - 1492 EP - 1498 SN - 0027-8874 AD - Li, J. Y.: Biostatics Branch, Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19942027314. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - To determine whether supplementation with multiple vitamins and minerals may reduce oesophageal/gastric cardia cancer among persons in Linxian, China, with oesophageal dysplasia, the authors conducted a 6-year prospective intervention trial in Linxian. Mortality and cancer incidence were ascertained from May 1985 through May 1991 for 3318 persons with cytologic evidence of oesophageal dysplasia who were randomly assigned to receive, throughout that period, daily supplementation with 14 vitamins and 12 minerals or placebo. Doses were typically 2-3 times US Recommended Daily Allowances. Compliance was assessed by counting unused pills monthly for all trial participants and by assaying nutrient levels in blood collected from samples of individuals randomly selected without replacement every 3 months throughout the trial. Cancers were identified through routine surveillance and by special cytology and endoscopy screenings after 21/2 years and 6 years. A total of 324 deaths occurred during the 6-year intervention period; 167 occurred in the control (placebo) group and 157 occurred in the supplement group. Cancer was the leading cause of death (54% of all deaths); 18% were due to cerebrovascular diseases and 29% to other causes. Cumulative oesophageal/gastric cardia death rates were 8% lower (relative risk [RR] = 0.92; 95% confidence interval [CI] = 0.67-1.28) among individuals receiving supplements rather than placebo, a non-significant (P >0.10) difference. Risk of total mortality was 7% lower (RR = 0.93; 95% CI = 0.75-1.16; P >0.10), total cancer 4% lower (RR = 0.96; 95% CI = 0.71-1.29; P >0.10), cerebrovascular disease 38% lower (RR = 0.62; 95% CI = 0.37-1.06; P = 0.08), and other diseases 12% higher (RR = 1.12; 95% CI = 0.74-1.69; P >0.10) among the treated group. Cumulative cancer incidence rates were nearly the same in the two groups. The authors conclude that no substantial short-term beneficial effect on incidence or mortality for this type of cancer occurred following daily supplementation with multiple vitamins and minerals among adults with precancerous lesions of the oesophagus. Longer follow-up should be more informative about the effectiveness of this 6-year supplementation on cancer and other diseases among individuals with oesophageal dysplasia. From AS KW - epidemiology KW - neoplasms KW - oesophagus KW - stomach KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - esophagus KW - nutrition intervention KW - People's Republic of China KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027314&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Migration patterns and breast cancer risk in Asian-American women. AU - Ziegler, R. G. AU - Hoover, R. N. AU - et al. AU - Pike, M. C. ( JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 22 SP - 1819 EP - 1827 SN - 0027-8874 AD - Ziegler, R. G.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028026. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - A population-based, case-control study of breast cancer among women of Chinese, Japanese, and Filipino ethnicities, aged 20-55 years, was conducted during 1983-1987 in San Francisco-Oakland, California, Los Angeles, California, and Oahu, Hawaii. The authors successfully interviewed 597 case subjects (70% of those eligible) and 966 control subjects (75%). A six-fold gradient in breast cancer risk by migration patterns was observed. Asian-American women born in the West had a breast cancer risk 60% higher than Asian-American women born in the East. Among those born in the West, risk was determined by whether their grandparents, especially grandmothers, were born in the East or the West. Asian-American women with three or four grandparents born in the West had a risk 50% higher than those with all grandparents born in the East. Among the Asian-American women born in the East, breast cancer risk was determined by whether their communities prior to migration were rural or urban and by the number of years subsequently lived in the West. Ethnic-specific incidence rates of breast cancer in the migrating generation were clearly elevated above those in the countries of origin, while rates in Asian-Americans born in the West approximated the US White rate. The authors conclude that exposure to Western lifestyles had a substantial impact on breast cancer risk in Asian migrants to the United States during their lifetime. There was no direct evidence of an especially susceptible period, during either menarche or early reproductive life. Because heterogeneity in breast cancer risk in these ethnic populations is similar to that in international comparisons and because analytic epidemiologic studies offer the opportunity to disentangle correlated exposures, this study should provide new insights into the aetiology of breast cancer. From AS KW - Asians KW - breast KW - breast cancer KW - epidemiology KW - neoplasms KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028026&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Saturated fat intake and lung cancer risk among nonsmoking women in Missouri. AU - Alavanja, M. C. R. AU - Brown, C. C. AU - Swanson, C. AU - Brownson, R. C. AU - Kolonel, L. N. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 23 SP - 1906 EP - 1916 SN - 0027-8874 AD - Alavanja, M. C. R.: Division of Cancer Etiology, National Cancer Institute, 6130 Executive Blvd., Rm. 543, Rockville, MD 20852, USA. N1 - Accession Number: 19942028027. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A telephone-administered questionnaire was used to determine and/or verify eligibility with regard to age, gender, race, and smoking status. In a second interview at the participant's home, a widely used food frequency questionnaire was filled out, and logistic regression was subsequently used to analyse the responses. [The authors] obtained dietary information on 429 case subjects who had a diagnosis of lung cancer reported to the Missouri Cancer Registry (USA) between June 1, 1986, and June 1, 1991, and 1021 control subjects. A strongly increasing trend in lung cancer risk was observed with increased saturated fat consumption among these non-smoking women; the relative risk was more than six-fold greater for the highest quintile of consumption than for the lowest quintile. The effect of saturated fat was more pronounced for adenocarcinoma than for other cell types. Weekly servings of beans and peas were significantly related to decreased lung cancer risk, while citrus fruit and juice showed a two-fold increase in risk; this trend was also significant. The authors conclude that by focusing on non-smoking women with lung cancer, including a large number with adenocarcinoma, a clear association with saturated fat consumption was observed that may have been masked in earlier studies of lung cancer involving a high percentage of smokers. [This topic is also discussed in an editorial by Laurence N. Kolonel on p. 1886 of this issue.] From AS KW - diet KW - dietary fat KW - fat KW - lung cancer KW - lungs KW - neoplasms KW - Nutrition KW - risk KW - women KW - Missouri KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancer sites KW - cancers KW - source fat KW - United States of America KW - Women (UU500) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028027&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow. AU - Sandler, D. P. AU - Shore, D. L. AU - et al. AU - Anderson, J. R. ( JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1993/// VL - 85 IS - 24 SP - 1994 EP - 2003 SN - 0027-8874 AD - Sandler, D. P.: National Institute of Environmental Health Sciences, Mail Drop A3-05, PO Box 12233, Research Triangle Park, NC 27703, USA. N1 - Accession Number: 19942027222. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors' purpose was to investigate the leukaemia risk associated with cigarette smoking in a multicentre case-control study of acute leukaemias. Adults aged 18-79 with newly diagnosed leukaemia were contacted to participate in this epidemiological study when they entered a clinical trial to be treated under protocols sponsored by Cancer and Leukaemia Group B. Smoking histories for 610 patients with acute leukaemia and 618 population control subjects were obtained by telephone interviews. The authors calculated odds ratio (ORs) for risk of leukaemia associated with smoking cigarettes. ORs were adjusted for age, race, and sex. Smoking was associated only with a modest increase in risk for leukaemia overall (adjusted OR = 1.13, 95% confidence interval [CI] = 0.89-1.44). However, among participants aged 60 and older, smoking was associated with a two-fold increase in risk for acute myeloid leukaemia (AML) (OR = 1.96; 95% CI = 1.17-3.28) and a three-fold increase in risk for acute lymphocytic leukaemia (ALL) (OR = 3.40; 95% CI = 0.97-11.9). Among older persons, risks increased with amount and duration of smoking. Smoking was associated with increased risk for AML classified as FAB type M2 at all ages, with ORs of 1.70 (95% CI = 1.00-2.90) for those younger than 60 and 3.50 (95% CI = 1.53-8.03) for those aged 60 and older. Smoking was also associated with ALL type L2 at all ages, with ORs of 1.72 (95% CI = 0.90-3.27) for those younger than 60 and 5.34 (95% CI = 1.03-27.6) for those who were older. Smoking was more common among patients with specific chromosome abnormalities in AML [-7 or 7q, -Y, +13] and in ALL [t(9;22)(q34;q11)]. The authors conclude that cigarette smoking is associated with increased risk for leukaemia and may lead to leukaemias of specific morphologic and chromosomal types. The association varies with age. Examining discrete subtypes of disease may permit more accurate assessment of risk. From AS KW - leukaemia KW - risk factors KW - Tobacco smoking KW - blood cancer KW - leucaemia KW - leukemia KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027222&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemotherapy for patients with pulmonary Kaposi's sarcoma: benefit of filgrastim (G-CSF) in supporting dose administration. AU - Sloand, E. AU - Kumar, P. N. AU - Pierce, P. F. JO - Southern Medical Journal JF - Southern Medical Journal Y1 - 1993/// VL - 86 IS - 11 SP - 1219 EP - 1224 SN - 0038-4348 AD - Sloand, E.: National Institutes of Health, Building 31, Room 5A49, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005457. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Clinical aspects KW - drug therapy KW - HIV infections KW - Kaposi's sarcoma KW - lungs KW - Treatment KW - AIDS KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005457&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Correlates of HIV risk behaviour among HIV infected prisoners. AU - Grace, W. C. T2 - Addiction JO - Addiction JF - Addiction Y1 - 1993/// VL - 88 IS - 6 SP - 836 EP - 836 SN - 0965-2140 AD - Grace, W. C.: National Institute on Drug Abuse, Room 11A-33, Rockville, MD 20857, USA. N1 - Accession Number: 19942024283. Publication Type: Correspondence. Language: English. KW - behaviour KW - HIV infections KW - Prevention KW - Prisoners KW - Risk behaviour KW - Sociology KW - behavior KW - human immunodeficiency virus infections KW - risk behavior KW - social aspects KW - Social research KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942024283&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A randomized, controlled trial of recombinant α-interferon therapy for chronic hepatitis B. AU - Bisceglie, A. M. di AU - Fong, T. L. AU - Fried, M. W. AU - Swain, M. G. AU - Baker, B. AU - Korenman, J. AU - Bergasa, N. V. AU - Waggoner, J. G. AU - Park, Y. AU - Hoofnagle, J. H. JO - American Journal of Gastroenterology JF - American Journal of Gastroenterology Y1 - 1993/// VL - 88 IS - 11 SP - 1887 EP - 1892 SN - 0002-9270 AD - Bisceglie, A. M. di: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. N1 - Accession Number: 19952007253. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9008-11-1. N2 - The authors evaluated the effect of recombinant α-interferon in chronic hepatitis B. Patients in Maryland, USA were stratified at entry according to their serum aspartate aminotransferase (AST) values, randomized to receive α-interferon (alfa-2b, 10 million units three times weekly) or to be untreated controls for 16 weeks. Effect of therapy on levels of hepatitis B viral (HBV) DNA and aminotransferase activities in serum and hepatitis B e antigen (HBeAg) status was monitored. Forty-seven patients entered the trial; 11 of 25 (44%) patients receiving interferon responded by clearing HBeAg and HBV DNA within 6 months, compared to one of 22 (5%) controls (P <0.05). Among those with serum AST values <100 U/L, 33% responded and among those with AST values >100 U/L, 60% responded. Within the 6-month study period, 36% of treated patients had normal serum alanine aminotransferase (ALT) values, and 16% had cleared hepatitis B surface antigen (HBsAg) from serum, whereas none of the controls had normal ALT values or had lost HBsAg. Interferon was stopped early in three patients (6.5%), and dosage was reduced in a further 16 patients (35%) because of adverse effects. Predictive factors for a response were the pretreatment serum ALT and AST activities. α-Interferon therapy (three times weekly) is relatively well tolerated and is effective in clearing HBeAg and HBV DNA in approximately one-third of treated patients. KW - chronic course KW - chronic infections KW - hepatitis B KW - immunotherapy KW - interferon KW - Maryland KW - North America KW - USA KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007253&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. AU - Actor, J. K. AU - Shirai, M. AU - Kullberg, M. C. AU - Buller, R. M. L. AU - Sher, A. AU - Berzofsky, J. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 3 SP - 948 EP - 952 SN - 0027-8424 AD - Actor, J. K.: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940800937. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Helminthology N2 - Schistosoma mansoni-infected BALB/c mice, were challenged when cytokine imbalance was prominent, with a recombinant vaccinia virus expressing human immunodeficiency virus type 1 gp160. In contrast to control vaccinia-infected animals, S. mansoni plus vaccinia-infected mice did not produce significant Th1 cytokine responses upon in vitro stimulation with recombinant gp120, consistent with previous results for nonparasite antigens. However, more striking was the downregulation of the virus-specific CTL response not previously studied. Spleen cells from vaccinia-infected control mice displayed strong CD8+ cytolytic activity against gp160-transfected fibroblasts and fibroblasts pulsed with a peptide (P18) representing a CTL epitope of gp160. In contrast, mice coinfected with S. mansoni and vaccinia manifested absent or markedly reduced in vitro CTL activity even in the presence of exogenous interleukin 2. To determine whether this immune dysregulation might impact on viral clearance, virus titres were measured in tissues as a function of time. Mice infected with vaccinia virus alone rapidly cleared the virus, whereas in animals coinfected with S. mansoni, viral clearance was delayed by as much as 3 weeks in the liver and by several days in the spleen and lungs. These observations suggest that helminth infection may influence immune responses to concurrent viral infections. KW - experimental infections KW - helminthoses KW - helminths KW - HIV infections KW - human diseases KW - immunological deficiency KW - Immunology KW - laboratory animals KW - mixed infections KW - parasites KW - Schistosomiasis KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - vaccinia virus KW - viruses KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - bilharzia KW - bilharziasis KW - human immunodeficiency virus infections KW - immune deficiency KW - immunodeficiency KW - multiple infections KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940800937&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis C virus RNA in southern African blacks with hepatocellular carcinoma. AU - Bukh, J. AU - Miller, R. H. AU - Kew, M. C. AU - Purcell, R. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 5 SP - 1848 EP - 1851 SN - 0027-8424 AD - Bukh, J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022434. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - A sensitive and specific cDNA polymerase chain reaction (PCR) assay was used to detect hepatitis C virus (HCV) RNA in serum samples from 128 unselected southern African Blacks with hepatocellular carcinoma (HCC). HCV-RNA was found in 26 (20.3%). A first-generation ELISA for serum HCV antibodies gave only poor correlation with PCR results. With a second-generation ELISA (Abbott), anti-HCV was detected in 25 patients (19.5%), and 17 of these patients were positive for HCV-RNA. By application of a second-generation recombinant immunoblot assay (Chiron), anti-HCV positivity was confirmed in 14 of the 17 ELISA- and HCV-RNA-positive patients: 2 were indeterminate and 1 was anti-HCV negative. All 8 patients who were ELISA-antibody positive but HCV-RNA negative, were anti-HCV negative by immunoblot. Five patients were HCV-RNA positive, but antibody negative on both ELISAs. The mean age of HCC patients positive for HCV-RNA (52.3 years) was significantly higher (P <0.001) than that of negative patients (40.3 years). Patients positive for HCV-RNA were more likely to be urban dwellers than were negative patients. Seventy one patients (55.5%) had evidence of current hepatitis B virus (HBV) infection (positive for serum HBV-encoded surface antigen (HBsAg) and HBV core antibodies (anti-HBc)), and 50 patients (39.1%) had evidence of previous infection (positive for serum HBV surface antibodies (anti-HBs) and/or anti-HBc): only 7 (5.5%) had no evidence of current or previous infections by HBV. The prevalence of current HBV infection was significantly lower (P <0.001) in patients who were positive for HCV-RNA (7/26, 26.9%) than in those who were negative (64/102, 62.7%) a difference which was not dependent on gender, age, or geographical location (rural or urban) of the patients. A significant number of southern African Blacks with HCC had a current HCV but not a current HBV infection (19/128, 14.8%), suggesting that infection with HCV plays a role in the development of HCC in some members of this population. [The contributions of infections by HBV and HCV to HCC in the study population can be gauged by (i) 64 patients (50.0%) having current HBV alone, (ii) 35 (27.3%) having previous HBV alone, (iii) 15 (11.7%) having previous HBV and current HCV, (iv) 7 (5.5%) having current HBV and current HCV, (v) 4 (3.1%) having current HCV alone, and (vi) 3 (2.3%) having no infection. An earlier publication gave data on 152 control subjects, of whom (i) 9 (5.9%) had current HBV, and (ii) 75 (49.3%) had previous HBV, of whom 1 (0.7%) had anti-HCV antibodies (on radioimmunoassay) (M.C. Kew et al., Lancet, 1990, 335, 873).] Alan F. Fleming KW - Hepatitis C KW - liver KW - liver cancer KW - neoplasms KW - Africa KW - South Africa KW - hepatitis C virus KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - Southern Africa KW - Africa South of Sahara KW - Threshold Countries KW - cancer sites KW - cancers KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022434&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease. AU - Shahabuddin, M. AU - Toyoshima, T. AU - Aikawa, M. AU - Kaslow, D. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 9 SP - 4266 EP - 4270 SN - 0027-8424 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940500402. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 103782-08-7, 9001-06-3. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases N2 - During development of the mosquito midgut, malarial parasites must traverse a chitin-containing peritrophic matrix (PM) that forms around the food bolus. It was previously reported by M. Huber et al. (1991) [Proceedings of the National Academy of Sciences of the United States of America, 88: 2807-2810] that the parasite secretes a protein with chitinase activity and they suggested that parasite chitinase plays an important role in the parasite's egress from the blood meal. Now, it has been found, using Aedes aegypti/Plasmodium gallinaceum and Anopheles freeborni/P. falciparum systems, that allosamidin, a specific inhibitor of chitinase, completely blocked oocyst development in vivo and thus blocked malaria parasite transmission. Addition of exogenous chitinase to the blood meal prevented the PM from forming and reversed the transmission-blocking activity of allosamidin. Using exogenous chitinase, it was found that the PM does not limit the number of parasites that develop into oocysts, suggesting that the parasite produces sufficient quantities of chitinase to penetrate this potential barrier. In addition, it was found that treatment of parasite chitinase with a diisopropyl fluorophosphate-sensitive trypsin-like protease from the mosquito midgut or endoproteinase Lys-C increased its enzymatic activity. These results suggest that malaria parasites have evolved an intricate mechanism to adapt to the PM and the protease-rich environment of the mosquito midgut.<new para>ADDITIONAL ABSTRACT:<new para>During development in the mosquito midgut, malarial parasites must traverse a chitin-containing peritrophic matrix (PM) that forms around the food bolus. Previously Huber et al. (Huber, M., Cabib, E. and Miller, L.H. (1991) Proc. Natl. Acad. Sci., USA 88, 2807-2810) reported that the parasite secretes a protein with chitinase activity, and they suggested that parasite chitinase (EC 3.2.1.14) plays an important role in the parasite's egress from the blood meal. [The authors] found that allosamidin, a specific inhibitor of chitinase, completely blocked oocyst development in vivo and thus blocked malaria parasite transmission. Addition of exogenous chitinase to the blood meal prevented the PM from forming and reversed the transmission-blocking activity of allosamidin. Using exogenous chitinase, [the authors] also found that the PM does not limit the number of parasites that develop into oocysts, suggesting that the parasite produces sufficient quantities of chitinase to penetrate this potential barrier. In addition, [the authors] found that treatment of parasite chitinase with a diisopropyl fluorophosphate-sensitive trypsinlike protease from the mosquito midgut or endoproteinase Lys-C increased its enzymatic activity. These results suggest that malaria parasite has evolved an intricate mechanism to adapt to the PM and the protease-rich environment of the mosquito midgut. AS KW - allosamidin KW - chitinase KW - disease transmission KW - disease vectors KW - enzymes KW - human diseases KW - infection KW - infections KW - ookinetes KW - parasites KW - peritrophic membrane KW - transmission KW - Aedes aegypti KW - Anopheles freeborni KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium KW - Plasmodium falciparum KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium KW - chitinase activity KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variant-specific surface proteins of Giardia lamblia are zinc-binding proteins. AU - Nash, T. E. AU - Mowatt, M. R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 12 SP - 5489 EP - 5493 SN - 0027-8424 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19950807844. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 52-90-4. N2 - Giardia lamblia [G. duodenalis] undergoes surface antigen variation. The variant-specific surface proteins (VSPs) are a distinct family of cysteine-rich proteins. Characteristically, cysteine residues occur mostly as CXXC tetrapeptides. Four of the reported 5 VSPs contain a putative metal-binding domain that resembles other metal-binding motifs; the fifth is closely related but lacks an essential histidine. Three different native VSPs bound Zn2+, Co2+, Cu2+ and Cd2+ inhibited Zn2+ binding. Analysis of recombinant VSP fusion proteins showed that the putative binding motif bound Zn2+. Peptide fragments from other regions of the VSP contain CXXCXetaCXXC motifs that also bound Zn2+. Analysis of deduced amino acid sequences showed well-conserved CXXC spacing in three out of five VSPs, suggesting conservation of structure despite amino acid sequence divergence. The function of VSPs is unknown, but by binding Zn2+ or other metals in the intestine, VSPs may contribute to Zn2+ malnutrition or inhibition of metal-dependent intestinal enzymes, which would lead to malabsorption, a known consequence of giardiasis. KW - antigens KW - binding proteins KW - cysteine KW - malabsorption KW - nucleotide sequences KW - recombinant DNA KW - surface antigens KW - Giardia duodenalis KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - carrier proteins KW - DNA sequences KW - immunogens KW - malabsorption syndrome KW - zinc binding proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807844&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. AU - Gazzinelli, R. T. AU - Hieny, S. AU - Wynn, T. A. AU - Wolf, S. AU - Sher, A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 13 SP - 6115 EP - 6119 SN - 0027-8424 AD - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932024089. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Immunity against the intracellular protozoan Toxoplasma gondii is highly dependent on interferon γ (IFN-γ). [The authors] have previously shown that, in addition to T lymphocytes, natural killer (NK) cells can be stimulated by the parasite to produce this cytokine by a reaction requiring adherent accessory cells and tumour necrosis factor α. [The authors] now demonstrate that a recently characterized cytokine, interleukin 12 (IL-12), is also necessary for parasite-induced IFN-γ synthesis by NK cells. Anti-IL-12 antibodies completely inhibited T. gondii or bacterial endotoxin-stimulated IFN-γ production by NK-enriched spleen cells from severe combined immunodeficient mice. Moreover, potent NK cytokine responses were induced by the combination of IL-12 and tumour necrosis factor α. In addition, adherent spleen cells from scid/scid mice or thyoglycollate-elicited macrophages from BALB/c animals produced high levels of both IL-12 (p40) and tumour necrosis factor α mRNAs when exposed to either live tachyzoites, parasite extracts, or endotoxin, confirming that these cytokines are produced by accessory cells. Finally, in vivo studies showed that treatment with recombinant IL-12 results in prolonged survival of scid mice after infection with T. gondii by means of a response dependent on both IFN-γ and NK cells. Together the data argue that IL-12 is required for the T-cell-independent triggering of NK cells by intracellular parasites and that the cytokine may be useful for inducing this protective pathway in immunodeficient hosts.AS KW - immunology KW - natural killer cells KW - Toxoplasma gondii KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932024089&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. AU - Graziosi, C. AU - Pantaleo, G. AU - et al. AU - Butini, L. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 14 SP - 6405 EP - 6409 SN - 0027-8424 AD - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004853. Publication Type: Journal Article. Language: English. KW - antigenaemia KW - cellular biology KW - core protein p24 KW - Dynamics KW - HIV infections KW - Immunology KW - Pathogenesis KW - Pathology KW - replication KW - T lymphocytes KW - viral replication KW - viruses KW - antigenemia KW - cell biology KW - human immunodeficiency virus infections KW - p24 KW - p24 antigen KW - T cells KW - Viral burden KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004853&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. AU - Barillari, G. AU - Gendelman, R. AU - Gallo, R. C. AU - Ensoli, B. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 17 SP - 7941 EP - 7945 SN - 0027-8424 AD - Barillari, G.: (B. Ensoli) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005415. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - adhesion KW - cells KW - Kaposi's sarcoma KW - Pathogenesis KW - AIDS KW - Growth promotion KW - Tat KW - Vascular cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005415&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS. AU - Lisziewicz, J. AU - Sun, D. AU - et al. AU - Smythe, J. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 17 SP - 8000 EP - 8004 SN - 0027-8424 AD - Lisziewicz, J.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005416. Publication Type: Journal Article. Language: English. KW - Antiviral agents KW - Gene therapy KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - HUMAN IMMUNODEFICIENCY VIRUS KW - RNA decoy KW - Tat activation response elements KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005416&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication. AU - Gao, W. Y. AU - Cara, A. AU - Gallo, R. C. AU - Lori, F. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 19 SP - 8925 EP - 8928 SN - 0027-8424 AD - Gao, W. Y.: (F. Lori) Building 37, Room 6A09, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005063. Publication Type: Journal Article. Language: English. Registry Number: 127-07-1. KW - HIV infections KW - hydroxycarbamide KW - Inhibitors KW - Latent infections KW - replication KW - Treatment KW - viral replication KW - viruses KW - Deoxynucleoside metabolism KW - DNA synthesis KW - human immunodeficiency virus infections KW - hydroxyurea KW - latency KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005063&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes. AU - Rice, W. G. AU - Schaeffer, C. A. AU - Graham, L. AU - Bu, M. AU - McDougal, J. S. AU - Orloff, S. L. AU - Villinger, F. AU - Young, M. AU - Oroszlan, S. AU - Fesen, M. R. AU - Pommier, Y. AU - Mendeleyev, J. AU - Kun, E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 IS - 20 SP - 9721 EP - 9724 SN - 0027-8424 AD - Rice, W. G.: Laboratory of Antiviral Drug Mechanism, Program Resources, Inc./DynCorp., National Cancer Institute-Frederick Cancer Research and Development Center, Building 431 T-B, PO Box B, Frederick, MD 21702, USA. N1 - Accession Number: 19942050413. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - antiviral agents KW - HIV infections KW - nitroso compounds KW - AIDS KW - human immunodeficiency virus infections KW - nitrosobenzamide KW - viral synthesis inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050413&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils. AU - Goldfarb, L. G. AU - Brown, P. AU - Haltia, M. AU - Ghiso, J. AU - Frangione, B. AU - Gajdusek, D. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 SP - 4451 EP - 4454 SN - 0027-8424 AD - Goldfarb, L. G.: Building 36, Room 5B21, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022400. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - peptides KW - purification KW - synthesis KW - Creuzfeldt-Jakob disease KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022400&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. AU - Whitesell, L. AU - Geselowitz, D. AU - et al. AU - Chavany, C. ( JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1993/// VL - 90 SP - 4665 EP - 4669 SN - 0027-8424 AD - Whitesell, L.: Clinical Pharmacology Branch, National Cancer Institute, Building 10, Room 13N262, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022402. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrospinal fluid penetration KW - Oligodeoxynucleotide KW - phosphorothioate KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variation of lipoprotein(a) concentrations among individuals with the same apolipoprotein(a) isoform is determined by the rate of lipoprotein(a) production. AU - Rader, D. J. AU - Cain, W. AU - Zech, L. A. AU - Usher, D. AU - Brewer, H. B., Jr. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1993/// VL - 91 IS - 2 SP - 443 EP - 447 SN - 0021-9738 AD - Rader, D. J.: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 7N117, Bethesda, MD 20892, USA. N1 - Accession Number: 19941403848. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - A series of kinetic studies were performed using purified radiolabelled lipoprotein(a) (Lp(a)) in subjects (7 men, 3 women; 20 to 39 years old) with the same apolipoprotein(a) (apo(a)) isoform but different Lp(a) values. In 7 subjects with a single S4-apo(a) isoform and Lp(a) ranging from 1 to 13.2 mg/100 ml, the fractional catabolic rate (FCR) of 131labelled S2-Lp(a) (mean 0.328 per day) was not correlated with the plasma Lp(a) value (r = -0.346, P=0.45). In 2 S4-apo(a) subjects with a 10-fold difference in Lp(a) value, the FCRs of 125I-labelled S4-Lp(a) were similar in both subjects and not substantially different from the FCRs of 131I-S2-Lp(a) in the same subjects. In 4 subjects with a single S2-apo(a) isoform and Lp(a) values ranging from 9.4 to 91 mg/100 ml, Lp(a) concentration was highly correlated with Lp(a) production rate (r = 0.993, P=0.007), but poorly correlated with Lp(a) FCR (mean 0.304 per day). Analysis of Lp(a) kinetic parameters in all subjects revealed no significant correlation of Lp(a) value with Lp(a) FCR (r = -0.53, P=0.09) and a strong correlation with Lp(a) production rate (r = 0.99, P<0.0001). It is concluded that the substantial variation in Lp(a) values among persons with the same apo(a) phenotype is caused primarily by differences in Lp(a) production rate. KW - apolipoproteins KW - blood KW - cardiovascular diseases KW - genetic polymorphism KW - lipoproteins KW - metabolism KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403848&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. AU - Karp, C. L. AU - El-Safi, S. H. AU - Wynn, T. A. AU - Satti, M. M. H. AU - Kordofani, A. M. AU - Hashim, F. A. AU - Hag-Ali, M. AU - Neva, F. A. AU - Nutman, T. B. AU - Sacks, D. L. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1993/// VL - 91 IS - 4 SP - 1644 EP - 1648 SN - 0021-9738 AD - Karp, C. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804909. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9008-11-1, 130068-27-8. Subject Subsets: Protozoology; Tropical Diseases N2 - To assess lesional cytokine profiles in Sudanese patients with kala-azar, bone marrow aspirates from 10 patients with active kala-azar, 5 with treated kala-azar, 2 endemic controls and 2 USA controls were analysed using a quantitative reverse transcriptase polymerase chain reaction (PCR) technique to amplify specific mRNA sequences of multiple Th1-, Th2-, and/or macrophage-associated cytokines. Transcript levels of IL-10 as well as IFN-γ were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. These findings suggest that IL-10 may contribute to the pathogenesis of kala-azar by inhibiting the cytokine-mediated activation of host macrophages that is necessary for the control of Leishmania donovani infection.\From AS<new para>ADDITIONAL ABSTRACT:<new para>To assess lesional cytokine profiles in Sudanese patients with kala-azar, bone marrow aspirates from 10 patients with active kala-azar, 5 with treated kala-azar, 2 endemic controls and 2 USA controls were analysed using a quantitative reverse transcriptase polymerase chain reaction (PCR) technique to amplify specific mRNA sequences of multiple Th1-, Th2-, and/or macrophage-associated cytokines. Transcript levels of IL-10 as well as IFN-γ were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. These findings suggest that IL-10 may contribute to the pathogenesis of kala-azar by inhibiting the cytokine-mediated activation of host macrophages that is necessary for the control of Leishmania donovani infection. KW - Cytokines KW - Human diseases KW - immune response KW - Interferon KW - Interleukin 10 KW - Molecular genetics KW - parasites KW - pathogenesis KW - Polymerase chain reaction KW - Visceral leishmaniasis KW - Africa KW - Sudan KW - Leishmania donovani KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - ACP Countries KW - East Africa KW - Africa South of Sahara KW - Africa KW - Least Developed Countries KW - Developing Countries KW - biochemical genetics KW - immunity reactions KW - immunological reactions KW - PCR KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804909&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of humoral and cell-mediated anti-human immunodeficiency virus (HIV) responses in HIV sero-negative volunteers by immunization with recombinant gp160. AU - Kovacs, J. A. AU - Vasudevachari, M. B. AU - et al. AU - Easter, M. ( JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1993/// VL - 92 IS - 2 SP - 919 EP - 928 SN - 0021-9738 AD - Kovacs, J. A.: Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005895. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - This paper presents the results of a phase I/II trial of an HIV candidate vaccine in HIV-seronegative people, based on the recombinant gp160 manufactured by MicroGeneSys. [This is the preparation that has been used as a therapeutic vaccine in HIV-seropositive subjects and gained notoriety when the US Congress voted $20 million for a phase III study using the product, a decision which was rescinded after many protests from the scientific community that the trial should have been peer reviewed and that more than one candidate therapeutic vaccine should be tried.] The study used gp160 conjugated to alum and was administered intravascularly in a variety of doses (10-1280 µg) with several boosting schedules given up to 24 months. Antibody responses were detected with epitope-specific ELISAs, immunoblots and immunoneutralizing assays. Blastogenic responses were also determined. For the trial 138 volunteers (mean age 36 years) were enrolled. Antibody responses were seen in the group receiving 3 immunizations with 160 µg although maximal responses were elicited with three doses of 1280 µg. Titres fell after challenge although a rapid anamnestic response was seen after re-challenge. Responses to some epitopes such as the second conserved domain were seen more frequently than after natural infection. Neutralizing responses were [unfortunately] homologous and did not recognize heterologous strains. Blastogenic responses were seen following doses of 20 µg or higher and were usually sustained for >1 year, especially when the dose exceeded 160 µg. Heterologous recognition was seen but there was no response to SIV. The specificity of the response was determined by comparing the responses to some of the volunteers who received keyhole limpet haemocyanin. [The authors conclude that the vaccine is safe and immunogenic even though three volunteers developed autoimmune diseases. Although this was not an efficiency study, one of the volunteers who did not make an immune response became HIV positive after the study had finished.] A.G. Dalgleish KW - envelope protein gp160 KW - HIV infections KW - human immunodeficiency viruses KW - Immune response KW - Immunization KW - Immunology KW - Safety KW - Vaccines KW - North America KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - conjugated vaccines KW - gp160 KW - Human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005895&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. AU - Rader, D. J. AU - Schäfer, J. AU - Lohse, P. AU - Verges, B. AU - Kindt, M. AU - Zech, L. A. AU - Steinmetz, A. AU - Brewer, H. B., Jr. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1993/// VL - 92 IS - 2 SP - 1009 EP - 1017 SN - 0021-9738 AD - Rader, D. J.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951409621. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition KW - atherosclerosis KW - catabolism KW - cholesterol KW - high density lipoprotein KW - kinetics KW - transport KW - triacylglycerols KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - transportation KW - triglycerides KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409621&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. AU - King, C. L. AU - Mahanty, S. AU - Kumaraswami, V. AU - Abrams, J. S. AU - Regunathan, J. AU - Jayaraman, K. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1993/// VL - 92 IS - 4 SP - 1667 EP - 1673 SN - 0021-9738 AD - King, C. L.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804884. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2, 76057-06-2. Subject Subsets: Helminthology; Tropical Diseases N2 - The immunological mechanisms involved in maintenance of an asymptomatic microfilaraemic state (MF) in patients with lymphatic filariasis remain undefined. MF patients have impaired filarial antigen (Ag)-specific lymphocyte proliferation and decreased frequencies (Fo) of Ag-specific T cells, and yet elevated serum IgE and antifilarial IgG4. To investigate the mechanism of Ag-specific anergy in MF patients in contrast to amicrofilaremic individuals with chronic lymphatic obstruction (CP), the Fo of Ag-specific lymphocytes from peripheral blood mononuclear cells secreting either IL-4 or IFN-γ were assessed by filter spot enzyme-linked immunosorbent assay, and IL-10 and transforming growth factor-β (TGF-β) mRNA transcript levels were assessed by a semiquantitative reverse transcriptase polymerase chain reaction technique. The Fo of filaria-specific IL-4-secreting lymphocytes were equivalent in both MF (geometric mean [GM] = 1:11 700) and CP (GM = 1:29 300), whereas the Fo of IFN-γ-secreting lymphocytes were lower in MF (GM = 1:39 300) than in CP (GM = 1:4 200). When the ratio of IL-4/IFN-γ (T helper type 2 [Th2]/Th1)-secreting cells was examined, MF subjects showed a predominant Th2 response (8:1) compared with a Th1 response in CP individuals (1:4). mRNA transcript levels of IL-10 were also significantly elevated in MF compared with CP individuals. Further, IL-10 and TGF-β were showed to have a role in modulating the Ag-specific anergy among MF subjects, in that neutralizing anti-IL-10 or anti-TGF-β significantly enhanced lymphocyte proliferation response (by 220-1300%) to filarial Ags in MF individuals. These findings demonstrated that MF subjects respond to parasite antigen by producing a set of suppressive cytokines that may facilitate persistence of the parasite within humans while producing little clinical disease. KW - cytokines KW - filariasis KW - helminths KW - human diseases KW - immune response KW - immunology KW - infections KW - interferon KW - interleukin 10 KW - interleukin 4 KW - interleukins KW - parasites KW - T lymphocytes KW - transforming growth factor KW - Brugia malayi KW - man KW - Nematoda KW - Onchocercidae KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804884&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leukotriene B4 and interleukin-8 in human immunodeficiency virus-related pulmonary disease. AU - Lipschik, G. Y. AU - Doerfler, M. E. AU - Kovacs, J. A. AU - Travis, W. D. AU - Andrawis, V. A. AU - Lawrence, M. G. AU - Dichter, J. R. AU - Ognibene, F. P. AU - Shelhamer, J. H. JO - Chest JF - Chest Y1 - 1993/// VL - 104 IS - 3 SP - 763 EP - 769 SN - 0012-3692 AD - Lipschik, G. Y.: J. H. Shelhamer, Critical Care Department, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931251389. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 142298-00-8. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - Bronchoalveolar lavage (BAL) fluid samples from 5 normal volunteers, 5 asymptomatic HIV-positive patients, 10 HIV-positive patients with non-specific interstitial pneumonitis (NIP) and 19 HIV-positive patients with Pneumocystis carinii pneumonia (PCP) were analysed in order to investigate the pathogenesis of lung injury in PCP and NIP. Interleukin-8 (IL-8) and phospholipase A2 (PLA2) were elevated in patients with PCP, and IL-8 correlated with BAL fluid absolute neutrophil count. Leukotriene B4 (LTB4), IL-8 and PLA2 levels were elevated in patients with NIP; LTB4 and PLA2 levels correlated with absolute neutrophil count, and IL-8 correlated with alveolar-arterial oxygen pressure difference. IL-8 was elevated in the asymptomatic HIV-positive patients and there was a trend toward elevation of PLA2 in this group. It is concluded that IL-8 plays a role in the pathogenesis of lung injury in PCP and that IL-8 may be the principal neutrophil chemotaxin in this disease. PLA2 may also be involved in the pathogenesis of PCP, and LTB4 and IL-8 may be involved in the recruitment of neutrophils and subsequent lung injury of NIP. It is suggested that there are varying mechanisms by which inflammatory cells are recruited in the lung in different HIV-related diseases. KW - acquired immune deficiency syndrome KW - cytokines KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunology KW - infections KW - interleukin 8 KW - interleukins KW - leukotrienes KW - lungs KW - opportunistic infections KW - parasites KW - pathogenesis KW - predisposition KW - North America KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - fungus KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251389&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The discovery of the hepatitis viruses. AU - Purcell, R. H. JO - Gastroenterology JF - Gastroenterology Y1 - 1993/// VL - 104 IS - 4 SP - 955 EP - 963 SN - 0016-5085 AD - Purcell, R. H.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020655. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - history KW - Hepatitis viruses KW - History and Biography (BB500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020655&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B. AU - Hoofnagle, J. H. AU - Bisceglie, A. M. di AU - Waggoner, J. G. AU - Park, Y. JO - Gastroenterology JF - Gastroenterology Y1 - 1993/// VL - 104 IS - 4 SP - 1116 EP - 1121 SN - 0016-5085 AD - Hoofnagle, J. H.: National Institutes of Health, Building 10, Room 9C103, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020657. Publication Type: Journal Article. Language: English. Registry Number: 9008-11-1. Subject Subsets: Public Health N2 - ... Between 1984 and 1991, 18 patients with clinically-apparent cirrhosis due to hepatitis B were treated with interferon alfa at the Clinical Center of the National Institutes of Health [Maryland, USA]. Six treated patients (33%) had a sustained loss of hepatitis B virus DNA and hepatitis B e antigen (if present initially) and decrease of amino-transferase levels into the normal or near normal range. In follow-up, these 6 patients resolved all symptoms of cirrhosis and are alive and fully active. In contrast, the 12 patients who did not have a sustained loss of hepatitis B virus have had evidence of progressive liver disease, 6 have died and 4 underwent hepatic transplantation. Side effects of interferon were common and included bacterial infections (n = 5) and exacerbations of disease (n = 9). These findings indicate that interferon alfa is effective in selected patients with mildly decompensated cirrhosis due to hepatitis B. AS KW - chronic course KW - hepatitis KW - Hepatitis B KW - hepatitis C KW - interferon KW - treatment KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - alpha KW - alpha-interferon KW - America (North) KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020657&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changes in hepatitis C virus antigen in liver with antiviral therapy. AU - Di Bisceglie, A. M. AU - Hoofnagle, J. H. AU - Krawczynski, K. JO - Gastroenterology JF - Gastroenterology Y1 - 1993/// VL - 105 IS - 3 SP - 858 EP - 862 SN - 0016-5085 AD - Di Bisceglie, A. M.: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19932023310. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients [in the USA] with hepatitis C were studied [in 1987-1991] to make these assessments. Hepatitis C virus antigen was detected by immunofluorescence staining of snap-frozen liver biopsy sections. Hepatitis C virus antigen was present in 86% of patients; the amount and pattern of hepatitis C virus antigen staining did not correlate with the degree of hepatic injury as assessed by serum aminotransferase levels or liver histology or with the level of viral replication assessed by the titer of HCV RNA in serum. Patients who had a beneficial response to antiviral therapy had significantly less hepatitis C virus antigen staining in pretreatment liver biopsy specimens than those who did not respond. The degree of hepatitis C virus antigen staining decreased significantly following interferon-α therapy but not after ribavirin therapy. Hepatic hepatitis C virus antigen became undetectable after therapy in those patients who had a long-term beneficial response to therapy. [The authors conclude that] hepatic hepatitis C virus staining may be useful in predicting and monitoring the response to antiviral therapy. AS KW - antigens KW - antiviral agents KW - drug therapy KW - Hepatitis C KW - liver KW - therapy KW - antigenicity KW - chemotherapy KW - immunogens KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023310&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes. AU - Ward, G. E. AU - Miller, L. H. AU - Dvorak, J. A. JO - Journal of Cell Science JF - Journal of Cell Science Y1 - 1993/// VL - 106 IS - 1 SP - 237 EP - 248 SN - 0021-9533 AD - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804660. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - During invasion of an erythrocyte by a malaria merozoite, an indentation develops in the erythrocyte surface at the point of contact between the 2 cells. This indentation deepens as invasion progresses, until the merozoite is completely surrounded by a membrane known as the parasitophorous vacuole membrane (PVM). Fluorescent lipophilic probes and phospholipid analogues were incorporated into the erythrocyte membrane, and their fate was followed during PVM formation (by Plasmodium knowlesi) with low-light-level video fluorescence microscopy. The concentration of probe in the forming PVM was indistinguishable from the concentration of probe in the erythrocyte membrane, suggesting that the lipids of the PVM are continuous with and derived from the host cell membrane during invasion. In contrast, fluorescently-labelled erythrocyte surface proteins were largely excluded from the forming PVM. The data are consistent with a model for PVM formation in which the merozoite induces a localized invagination in the erythrocyte lipid bilayer, concomitant with a localized restructuring of the host cell cytoskeleton. KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - lipids KW - membranes KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - blood red cells KW - lipins KW - parasite host relationships KW - parasitophorous vacuole KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804660&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of a two-dose measles, mumps, and rubella vaccination schedule in a cohort of college athletes. AU - Coté, T. R. AU - Sivertson, D. AU - Horan, J. M. AU - Lindegren, M.L. AU - Dwyer, D. M. JO - Public Health Reports JF - Public Health Reports Y1 - 1993/// VL - 108 IS - 4 SP - 431 EP - 435 SN - 0033-3549 AD - Coté, T. R.: VEB-NCI, National Institutes of Health, 6130 Executive Blvd., EPN-434, Rockville, MD 20852, USA. N1 - Accession Number: 19942028360. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - ... To determine seroprevalence and response to vaccination in seronegative persons, [the authors] tested sera from 256 college athletes at a Maryland State [USA] college by enzyme-linked immunosorbent assay, vaccinated seronegatives, then re-tested vaccinees. High school records were obtained for persons seronegative to measles. Of 256 students, 53 (21%) were seronegative to measles alone, 13 (5%) were seronegative to rubella alone, and 5 (2%) were seronegative to both. Among those seronegative to measles, 86% had previously received a dose of measles vaccine. After vaccination, 37 persons initially seronegative to measles and 9 seronegative to rubella were 97% and 100% seropositive, respectively. The high measles seroconversion rate suggests that the two-dose vaccine schedule should effectively control campus measles outbreaks and, if given as measles-mumps-rubella vaccine, will also improve immunity to rubella and mumps. AS KW - combined vaccines KW - dosage KW - immunization KW - measles KW - Measles mumps rubella vaccines KW - students KW - Maryland KW - North America KW - USA KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - immune sensitization KW - mixed vaccines KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028360&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. AU - Rooney, J. F. AU - Straus, S. E. AU - et al. AU - Mannix, M. L. ( JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1993/// VL - 118 IS - 4 SP - 268 EP - 272 SN - 0003-4819 AD - Rooney, J. F.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Building 30, Room 121, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021064. Publication Type: Journal Article. Language: English. Registry Number: 59277-89-3. Subject Subsets: Public Health N2 - Twenty-two otherwise healthy adults aged 18-50 years with at least two attacks of herpes labialis (one confirmed by viral culture) in a 4-month observation period were entered into a randomized double-blind placebo-controlled crossover study of acyclovir by the United States National Institutes for Dental Research and Allergy and Infectious Diseases. Acyclovir was given orally 400 mg twice daily for four months. Two patients withdrew from the study, one because of headache and nausea after 5 doses of acyclovir, and a second for administrative reasons. Recurrences were documented by clinical examination and viral culture. All isolates in the observation and therapy periods from the 20 remaining subjects were herpes simplex virus type 1 with in vitro sensitivities to acyclovir of less than 1.0 µg/ml. The average number of recurrences and virologically confirmed recurrences in the 4-month treatment periods were respectively 0.85 and 0.40 for acyclovir and 1.80 and 1.40 for placebo. The time to first recurrence on treatment was 118 days (22-134 days) for acyclovir recipients and 46 days (7->122 days) for placebo recipients (P = 0.05). After treatment was discontinued recurrent lesions developed on average after 28 days for both acyclovir and placebo recipients. This study shows that oral treatment with acyclovir is of value in the management of patients with frequent recurrent herpes labialis.D.S. Freestone KW - aciclovir KW - Herpes simplex KW - relapse KW - treatment KW - acyclovir KW - herpes simplex labialis KW - recurrence of disease KW - relapses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021064&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antibody response to Blastocystis hominis infections. AU - Zierdt, C. H. AU - Nagy, B. T2 - Annals of Internal Medicine JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1993/// VL - 118 IS - 12 SP - 985 EP - 986 SN - 0003-4819 AD - Zierdt, C. H.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950802335. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology N2 - The correspondent describes a study of the presence of antibodies to Blastocystis hominis in sera from 19 patients with symptomatic B. hominis infection. The average specific IgG antibody titre was 1/268 with indirect fluorescent testing and 1/405 with ELISA. The average titre for 50 normal (blood bank) sera was 1/24 by IFA and all normal sera were negative by ELISA. Titres for paired acute-phase sera were much higher than those reported for giardiasis, even though both parasites are non-invasive. KW - antibodies KW - giardiasis KW - human diseases KW - immune response KW - parasites KW - Blastocystis hominis KW - man KW - protozoa KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - giardiosis KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802335&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Daily energy expenditure by five-year-old children, measured by doubly labeled water. AU - Fontvieille, A. M. AU - Harper, I. T. AU - Ferraro, R. T. AU - Spraul, M. AU - Ravussin, E. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1993/// VL - 123 IS - 2 SP - 200 EP - 207 SN - 0022-3476 AD - Fontvieille, A. M.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19941405365. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition N2 - Total energy expenditure (TEE) was estimated with doubly labelled water and resting metabolic rate (RMR) by indirect calorimetry in white children (15 boys 5.4±0.3 and 13 girls 5.5±0.4 years old). Measured TEE was 1370±222 kcal daily, significantly lower than the FAO/WHO recommended daily intake of 1807±310 kcal. Measured RMR was 1001±119, significantly higher than predicted 952±78 kcal daily. The energy cost of physical activity was only 231±131 kcal. An index of activity, assessed as the difference between measured and predicted TEE, was correlated positively with sport and leisure activity during the past year assessed by questionnaire. It is concluded that most of the difference between measured and predicted TEE seems to be due to less physical activity than expected and that this may be related to increased television viewing. KW - children KW - energy cost of activities KW - energy intake KW - energy requirements KW - exercise KW - physical activity KW - resting energy exchange KW - television KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405365&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hydrolysis of proline dipeptides completely fulfills the proline requirement in a proline-auxotrophic Chinese hamster ovary cell line. AU - Emmerson, K. S. AU - Phang, J. M. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1993/// VL - 123 IS - 5 SP - 909 EP - 914 SN - 0022-3166 AD - Emmerson, K. S.: J. M. Phang, Laboratory of Nutritional and Molecular Regulation, Division of Cancer Prevention and Control, The National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19931464530. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 147-85-3. Subject Subsets: Human Nutrition N2 - Proline and hydroxyproline-containing oligopeptides may be important in protein nutrition because intestinal hydrolases are incapable of recognizing their imido bonds. Peripheral tissues have a cytosolic enzyme prolidase that cleaves dipeptides containing C-terminal proline (X-Pro) or hydroxyproline. The role of dipeptides in intracellular metabolism is uncertain. The study examined the ability of X-Pro to provide proline to the proline-auxotrophic cell line, CHO-K1. The action of prolidase on exogenously supplied Gly-Pro, the most abundant dipeptide product of digestion, provided adequate proline to support normal cell growth of CHO-K1 cells in a dose-dependent manner. The growth curve generated by addition of Gly-Pro to CHO-K1 cells was similar to that due to proline. Two other structurally unrelated X-Pro also supported growth indistinguishably from Gly-Pro. Gly-Hyp was completely ineffective for growth. The ability of X-Pro to sustain cultures of a proline-auxotrophic cell line may be important in elucidating intracellular nutritional and physiological functions for those dipeptides. KW - cell cultures KW - dipeptides KW - growth KW - Proline KW - Cricetulus barabensis KW - hamsters KW - Cricetulus KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464530&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A summary of the workshop "Alcohol and calories: a matter of balance". AU - Lands, W. E. M. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1993/// VL - 123 IS - 7 SP - 1338 EP - 1341 SN - 0022-3166 AD - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rochville, MD 20857, USA. N1 - Accession Number: 19931466305. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition KW - alcoholic beverages KW - energy intake KW - intake KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Alcohol and calories: a matter of balance KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466305&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High fiber diets slow bone turnover in young men but have no effect on efficiency of intestinal calcium absorption. AU - O'Brien, K. O. AU - Allen, L. H. AU - Quatromoni, P. AU - Siu-Caldera, M. L. AU - Vieira, N. E. AU - Perez, A. AU - Holick, M. F. AU - Yergey, A. L. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1993/// VL - 123 IS - 12 SP - 2122 EP - 2128 SN - 0022-3166 AD - O'Brien, K. O.: National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6C101, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402053. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 7440-70-2, 9002-64-6, 1406-16-2. Subject Subsets: Human Nutrition N2 - The effects of a high fibre diet on calcium balance and kinetics and on Ca-regulating hormones were investigated in 7 young men who participated in two 23-day studies. In the low fibre period, diet provided fibre 6.5 g and Ca 530 mg daily. In the high fibre period fibre was increased to 31.3 g and Ca to 586 mg daily by substituting high fibre cereal. Estimated between 7 and 12 days of each period, the high fibre diet significantly lowered the apparent absorption of Ca (from 60.9±23.8 to 37.1±26.5%) and reduced Ca balance, although balance remained positive overall. Fibre had no effect on serum total or ultrafiltrable Ca, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D or parathyroid hormone concentrations estimated after 1, 7, 12 and 20 days. Ca kinetics was studied between 17 and 23 days by administering oral 44Ca and intravenous 42Ca to fasting subjects. Fractional absorption of Ca in the fasting state was unaffected by fibre. However, during the high fibre period, men had significantly lower bone accretion, resorption and turnover rates, and Ca flow to bone from the exchangeable pool than during the low fibre period. It is concluded that the fibre-induced reduction in Ca absorption reduced bone Ca turnover but did not increase the efficiency of intestinal absorption. KW - bones KW - calcium KW - calcium absorption KW - fibre KW - hormones KW - intake KW - men KW - metabolism KW - parathyrin KW - vitamin D KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fiber KW - parathyroid hormone KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402053&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional epidemiology of cervical neoplasia. AU - Potischman, N. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1993/// VL - 123 IS - 2/2 SP - 424 EP - 429 SN - 0022-3166 AD - Potischman, N.: Environmental Studies Section, Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931464487. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - There seems to be a natural progression of some preinvasive cervical lesions to more advanced lesions. Although research has evaluated the associations between nutrients and particular preinvasive lesions or invasive disease, little work has been done to compare results across the spectrum of lesions in the progression to invasive disease. This review compiles studies that have evaluated the relation between nutrients and cervical neoplasia and evaluates the general consistency of the literature across stage of disease. Preformed vitamin A does not seem to be related to risk of any preinvasive or invasive lesions, whereas vitamin C has been associated with a reduced risk of dysplasia, in situ cancer, and invasive disease, particularly among smokers. There was evidence of reduced risks associated with various carotenoids and vitamin E at all stages of the disease process, although these studies were inconsistent and further work is needed. Folate was the only nutrient that seemed to be protective for dysplastic lesions and not related to risk of in situ or invasive disease. Red blood cell folate was a better predictor of dysplasia than were serum or dietary folate, and further investigation using this marker of folate status is warranted. Research is needed across a spectrum of lesions within one study, with particular attention to interactions between nutrients and other risk factors for disease. KW - Carcinoma KW - cervix KW - diet KW - Neoplasms KW - reviews KW - Man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464487&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunohistochemical localization of laminin in the hearts of patients with chronic chagasic cardiomyopathy: relationship to thickening of basement membranes. AU - Sanchez, J. A. AU - Milei, J. AU - Yu, Z. X. AU - Storino, R. AU - Wenthold, R., Jr. AU - Ferrans, V. J. JO - American Heart Journal JF - American Heart Journal Y1 - 1993/// VL - 126 IS - 6 SP - 1392 EP - 1401 SN - 0002-8703 AD - Sanchez, J. A.: Pathology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19950802319. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology N2 - The histological and ultrastructural appearance of endomyocardial tissue from 10 patients with chronic cardiomyopathy secondary to Trypanosoma cruzi was evaluated. Examination revealed marked thickening of the basement membranes of endothelial cells, myocytes and vascular muscle cells. Immunohistochemical analysis demonstrated a positive reaction for laminin in the thickened membranes. It is suggested that the cause of such thickening may result from an immunological response to tissue injury leading to some of the basement membrane components developing antigenicity. Other possibilities include myocardial fibrosis with the development of new connective tissue components, or to an immunological reaction resulting from the presence of a laminin-like molecule on the surface membrane of T. cruzi amastigotes and promastigotes. KW - cardiomyopathy KW - cell membranes KW - Chagas' disease KW - electron microscopy KW - fibrosis KW - heart KW - heart diseases KW - human diseases KW - immunohistochemistry KW - immunopathology KW - laminins KW - parasites KW - pathology KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosoma cruzi KW - Trypanosomatidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Protozoa KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - coronary diseases KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802319&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets. AU - Boschero, A. C. AU - Crepaldi, S. C. AU - Carneiro, E. M. AU - Delattre, E. AU - Atwater, I. JO - Endocrinology (Philadelphia) JF - Endocrinology (Philadelphia) Y1 - 1993/// VL - 133 IS - 2 SP - 515 EP - 520 SN - 0013-7227 AD - Boschero, A. C.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19930463423. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7440-70-2, 50-99-7, 9004-10-8, 9002-62-4. Subject Subsets: Dairy Science; Human Nutrition N2 - The effects of prolactin (PRL) treatment on insulin content and secretion, and 86Rb and 45Ca fluxes from neonatal rat islets maintained in culture for 7-9 days were studied. PRL treatment enhanced islet insulin content by 40% and enhanced early insulin secretion evoked by 16.7 mM glucose. Insulin release stimulated by oxotremorine-M, a muscarinic agonist, in the presence of glucose (8.3 or 16.7 mM) was unchanged by PRL treatment. However, PRL treatment potentiated phorbol 12,13-dibutyrate-stimulated insulin secretion in the presence of the above glucose concentrations. PRL treatment potentiated the reduction in 86Rb efflux by glucose or tolbutamide and enhanced the increase in 86Rb efflux evoked by diazoxide. PRL treatment slightly potentiated the increment in 45Ca uptake induced by high concentrations of K+, but failed to affect the increment evoked by 16.7 mM glucose. Since glucose-induced 45Ca uptake was not affected by PRL, it is suggested that the enhancement in 1st-phase insulin secretion evoked by glucose in the PRL-treated islets occurs at a step in the secretory process that may involve protein kinase-C. These data further support observations that PRL treatment increases islet sensitivity to glucose. KW - calcium KW - cell cultures KW - glucose KW - insulin KW - insulin secretion KW - pancreas KW - pancreas islets KW - prolactin KW - release KW - uptake KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dextrose KW - insulin release KW - lactogenic hormone KW - mammotropin KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930463423&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of dietary phosphorus-dependent duodenal calcium uptake in vitamin D-deficient chicks. AU - Liang, C. T. AU - Barnes, J. AU - Sacktor, B. AU - Balakir, R. A. JO - Journal of Membrane Biology JF - Journal of Membrane Biology Y1 - 1993/// VL - 134 IS - 3 SP - 189 EP - 196 SN - 0022-2631 AD - Liang, C. T.: National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19961400318. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 7440-70-2, 1406-16-2. Subject Subsets: Human Nutrition; Animal Nutrition N2 - The effect of dietary phosphorus on intestinal calcium uptake was examined in duodenal cells isolated from vitamin D-deficient chicks. Cells from chicks on a high P diet accumulated Ca at a rate 38% higher than cells from chicks on a normal P diet. Diet high in Ca did not affect Ca absorption in duodenal cells. The dietary P effect on Ca absorption was specific. Uptake of α-methyl glucoside was not altered. Increase in Ca absorption by a high P diet was not due to change in cellular energy metabolism nor to the content of P in cells. Kinetically, a high P diet decreased the Vmax of Ca uptake; the affinity for Ca was unaffected. The effectiveness of dietary P to enhance the intestinal Ca uptake was also observed in brush border membranes vesicles. The increase in Ca uptake was not due to an alteration in membrane binding capacity nor to Ca efflux from vesicles. The phospholipid content in isolated brush border membranes was also examined. The content of phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine was not altered by the high P diet. The results suggest that the vitamin D-independent and dietary P-dependent effect on intestinal Ca absorption was primarily due to a change in the Ca flux at the luminal side of the cells. KW - calcium KW - chicks KW - deficiency KW - duodenum KW - intestinal absorption KW - minerals KW - vitamin D KW - vitamins KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400318&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cigarette smoking and the risk of endometrial cancer. AU - Brinton, L. A. AU - Barrett, R. J. AU - Berman, M. L. AU - Mortel, R. AU - Twiggs, L. B. AU - Wilbanks, G. D. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 137 IS - 3 SP - 281 EP - 291 SN - 0002-9262 AD - Brinton, L. A.: Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19932021437. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health N2 - From a study of 405 cases and 297 controls the authors conclude that the results "support the notion that smoking reduces the risk of endometrial cancer through extraovarian endogenous hormonal mechanims. Further studies, [they argue], are needed to clarify why reduced risks are most pronounced among postmenopausal women and those currently exposed to cigarette smoke." However, none of the relations they observed attained statistical significance. D.W. FitzSimons KW - endometrium KW - female genitalia KW - genitalia KW - neoplasms KW - risk factors KW - smoking KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - cancer sites KW - cancers KW - endometrial area KW - female genital system KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932021437&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cohort study of alcohol consumption and risk of breast cancer. AU - Friedenreich, C. M. AU - Howe, G. R. AU - Miller, A. B. AU - Jain, M. G. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 137 IS - 5 SP - 512 EP - 520 SN - 0002-9262 AD - Friedenreich, C. M.: National Cancer Institute of Canada Epidemiology Unit, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. N1 - Accession Number: 19951404082. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - The association between alcohol consumption and breast cancer risk was examined in 519 newly incident, histologically confirmed cases of breast cancer diagnosed between 1982 and 1987 within a cohort of 56 837 women enrolled in the Canadian National Breast Screening Study. These women had completed a self-administered food frequency questionnaire including alcohol consumption at enrollment into the study prior to their breast cancer diagnosis. For the total cohort, only a weak association between total alcohol consumption and breast cancer risk was observed, the adjusted relative risk for those drinking ≥30 g/day being 1.22 (95% confidence interval (CI) 0.78 to 1.90) compared with nondrinkers. There is some evidence for a positive association in women who were premenopausal at the time of enrollment for whom there was a monotonic increase in risk with increasing alcohol intake. Compared with nondrinkers, the adjusted relative risk for alcohol consumption of alcohol between 0 and <10 g daily was 1.11 (95% CI 0.71 to 1.71), between 10 and <20 g was 1.37 (95% CI 0.79 to 2.36), between 20 and <30 g was 1.51 (95% CI 0.80 to 2.86) and >30 g was 1.86 (95% CI 0.96 to 3.66; P=0.07). These findings contrasted with the results for postmenopausal women where there appeared to be no evidence of any relation. The association in premenopausal women is generally reasonably consistent with that of other studies that have found positive associations with alcohol intake. KW - alcoholic beverages KW - breast cancer KW - intake KW - mammary gland neoplasms KW - menopause KW - neoplasms KW - risk KW - risk factors KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - mammary tumour KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404082&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary patterns associated with a low-fat diet in the National Health Examination follow-up study: identification of potential confounders for epidemiologic analyses. AU - Ursin, G. AU - Ziegler, R. G. AU - Subar, A. F. AU - Graubard, B. I. AU - Haile, R. W. AU - Hoover, R. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 137 IS - 8 SP - 916 EP - 927 SN - 0002-9262 AD - Ursin, G.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951407789. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - To identify systematically the nutrient and food group intakes associated with a low-fat diet, detailed dietary information collected from 10 306 individuals 32-86 years old in the 1982-1984 National Health Epidemiologic Follow-up Study was used. Intakes of vitamin C and percentages of energy from carbohydrates, dietary fibre, poultry, low-fat dairy products, fruits, vegetables, cereals and whole grains were markedly higher, while intakes of protein, total fat, saturated fat, oleic and linoleic acids, cholesterol, sodium, all red meats, high-fat dairy products, eggs, nuts, white bread, fried potatoes, desserts, fats and oils were much lower in the quartile with the lowest percentage of energy from fat. These dietary patterns associated with a low-fat diet were essentially constant across strata of age, sex, race and socioeconomic status. This study suggests that individuals on a low-fat diet substitute certain carbohydrate-rich foods such as fruits and vegetable for fat. Given those associations between low-fat diets and other dietary factors independently associated with certain cancers, these dietary factors should be considered potential confounders in studies of dietary fat and these cancers. KW - carcinoma KW - diet studies KW - epidemiology KW - fats KW - intake KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407789&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overweight, weight loss, and risk of coronary heart disease in older women: the NHANES I Epidemiologic Follow-up Study. AU - Harris, T. B. AU - Ballard-Barbasch, R. AU - Madans, J. AU - Makuc, D. M. AU - Feldman, J. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 137 IS - 12 SP - 1318 EP - 1327 SN - 0002-9262 AD - Harris, T. B.: National Institute on Aging, Bethesda, MD 20892, USA. N1 - Accession Number: 19951405979. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition N2 - Measured body weight for 1259 white women aged 65-74 years from the Epidemiologic Follow-up Study of the First National Health and Nutrition Examination Survey was used to examine the effect of overweight on coronary heart disease incidence (mean length of follow-up 14 years). Reported lifetime maximum body weight was also used to examine the effect of weight loss on this association. Women with a Quetelet index (weight (kg)/height (m)²) of 29 or more showed an increased risk of coronary heart disease (relative risk (RR) = 1.5, 95% confidence interval (CI) 1.1-2.1) after adjustment for age and smoking in comparison with those with a Quetelet index of less than 21, while women with a Quetelet index of 23-24 had a lower risk of coronary heart disease (RR = 0.6, 95% CI 0.4-0.9). However, the pattern of risk associated with measured weight was modified by weight loss. Among heavier women whose weight was relatively stable, those with a Quetelet index of 29 or more had an increased risk of heart disease (RR = 2.7, 95% CI 1.7-4.4). Among those with greater weight loss, the relation between Quetelet index and risk of coronary heart disease was J-shaped. Overweight is an independent risk factor for coronary heart disease in older women, a finding strengthened after previous weight loss is accounted for. Reasons for the unexpected increase in risk of coronary heart disease in thinner women who lost weight are unclear, and further investigation is warranted. KW - aging KW - body weight KW - diet studies KW - heart diseases KW - old age KW - weight reduction KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ageing KW - coronary diseases KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405979&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interpretation of energy adjustment models for nutritional epidemiology. AU - Kipnis, V. AU - Freedman, L. S. AU - Brown, C. C. AU - Hartman, A. AU - Schatzkin, A. AU - Wacholder, S. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 137 IS - 12 SP - 1376 EP - 1380 SN - 0002-9262 AD - Kipnis, V.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951405981. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition N2 - The interpretation of 3 alternative energy adjustment models for nutritional epidemiology is discussed. It is shown that 4 different effects are addressed by these models: adding nutrient N, substituting nutrient N for "other" nutrients, adding "other" nutrients, and adding N and "other" nutrients in a specific ratio. Each of these effects may be estimated from any of the 3 models. The relative standard errors for the 4 estimated effects are also provided. KW - diet study techniques KW - epidemiology KW - mathematical models KW - methodology KW - nutrition KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - methods KW - Diet Studies (VV110) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405981&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for cancers of the nasal cavity and paranasal sinuses among white men in the United States. AU - Zheng, W. AU - McLaughlin, J. K. AU - Chow, W. H. AU - Chien, H. T. C. AU - Blot, W. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 138 IS - 11 SP - 965 EP - 972 SN - 0002-9262 AD - Zheng, W.: (J.K. McLaughlin) National Cancer Institute, 6130 Executive Blvd., EPN 415, Rockville, MD 20852, USA. N1 - Accession Number: 19942028169. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A case-control analysis of cancer of the nasal cavity and sinuses was performed using data from the 1986 National Mortality Followback Survey. Data on cigarette smoking, alcohol consumption, usual diet, and other factors from 147 white men who died from nasal cancer and from 449 controls who died from other causes were compared. Cigarette smoking was related to an increased risk of nasal cancer, with a doubling of risk among heavy or long-term smokers and a reduction in risk among long-term quitters. Among nonsmokers, having a spouse who smoked was associated with a significantly elevated risk of nasal cancer. After adjustment for smoking, a significant dose-response relation was also noted between alcohol drinking and risk of nasal cancer. High consumption of salted/smoked foods was associated with elevated risk, and risk tended to decrease with increasing intake of vegetables. Associations were more pronounced for cigarette smoking and certain dietary items when the analysis was restricted to maxillary sinus cancer. The study confirms that cigarette smoking is a risk factor for nasal cancer, and provides further evidence that dietary factors may play a role in the aetiology of this malignancy.AS KW - neoplasms KW - nose KW - paranasal sinuses KW - risk factors KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028169&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association of delayed conception with caffeine consumption. AU - Hatch, E. E. AU - Bracken, M. B. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1993/// VL - 138 IS - 12 SP - 1082 EP - 1092 SN - 0002-9262 AD - Hatch, E. E.: Epidemiology and Biostatistic Program, Division of Cancer Etiology, National Cancer Institute, EPN 408, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19942028174. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 58-08-2. Subject Subsets: Human Nutrition; Public Health N2 - This cross-sectional study investigated the relation between intake of caffeine-containing beverages and time to conception in a population of 1909 married women in New Haven, Connecticut, between May 12, 1980 and March 12, 1982. Women were interviewed shortly after the first prenatal visit regarding the length of time taken to conceive the index pregnancy, consumption of caffeine during pregnancy, and other exposures occurring prior to and during pregnancy. In logistic regression analyses, intake of caffeine from coffee, tea, and caffeinated soft drinks was associated with an increased risk of a delay of conception of 1 year or more. Compared with no caffeine use, consumption of 1-150 mg/day of caffeine resulted in an odds ratio for delayed conception of 1.39 (95% confidence interval (CI) 0.90-2.13), consumption of 151-300 mg/day of caffeine was associated with an odds ratio of 1.88 (95% CI 1.13-3.11), and that of over 300 mg/day (the equivalent of approximately three cups of coffee) resulted in an odds ratio of 2.24 (95% CI 1.06-4.73), after controlling for last method of birth control used, parity, and number of cigarettes per day. When the risk of conception for each cycle was examined using a discrete analogue of the Cox proportional hazards model, women who reported drinking over 300 mg/day of caffeine had a 27% lower chance of conceiving for each cycle, and those who reported drinking less than 300 mg/day had a 10% reduction in per cycle conception rates compared with women who consumed no caffeine. Risks for coffee, tea, and colas were examined simultaneously in logistic models and were found not to improve the fit of a model that contained a variable for total caffeine intake from all sources. AS<new para>ADDITIONAL ABSTRACT:<new para>This cross-sectional study investigated the relation between intake of caffeine-containing beverages and time to conception in a population of 1909 married women in New Haven, Connecticut, USA between May 12, 1980 and March 12, 1982. Women were interviewed shortly after the first prenatal visit regarding the length of time taken to conceive the index pregnancy, consumption of caffeine during pregnancy, and other exposures occurring prior to and during pregnancy. In logistic regression analyses, intake of caffeine from coffee, tea and caffeinated soft drinks was associated with an increased risk of a delay of conception of 1 year or more. Compared with no caffeine use, consumption of 1-150 mg/day of caffeine resulted in an odds ratio for delayed conception of 1.39 (95% confidence interval (CI) 0.90-2.13), consumption of 151-300 mg/day of caffeine was associated with an odds ratio of 1.88 (95% CI 1.13-3.11), and that of over 300 mg/day (the equivalent of approximately 3 cups of coffee) resulted in an odds ratio of 2.24 (95% CI 1.06-4.73), after controlling for last method of birth control used, parity and number of cigarettes per day. When the risk of conception for each cycle was examined using a discrete analogue of the Cox proportional hazards model, women who reported drinking over 300 mg/day of caffeine had a 27% lower chance of conceiving for each cycle, and those who reported drinking less than 300 mg/day had a 10% reduction in per cycle conception rates compared with women who consumed no caffeine. Risks for coffee, tea and colas were examined simultaneously in logistic models and were found not to improve the fit of a model that contained a variable for total caffeine intake from all sources. KW - Caffeine KW - coffee KW - conception KW - effects KW - female fertility KW - female infertility KW - fertility KW - health KW - tea KW - women KW - Connecticut KW - North America KW - USA KW - Camellia sinensis KW - Coffea KW - man KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Rubiaceae KW - Rubiales KW - Gentianales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) KW - Human Reproduction and Development (VV060) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028174&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among the three Borrelia species associated with Lyme disease. AU - Samuels, D. S. AU - Marconi, R. T. AU - Garon, C. F. JO - Journal of General Microbiology JF - Journal of General Microbiology Y1 - 1993/// VL - 139 IS - 10 SP - 2445 EP - 2449 SN - 0022-1287 AD - Samuels, D. S.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19930518591. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - The aetiological agents of Lyme disease form a phylogenetically heterologous group, composed of 3 species, B. burgdorferi, B. garinii and group VS461 [B. afzelii]. The sizes of the linear plasmid that carried the genes encoding the major outer-surface proteins OspA and OspB, as well as the size and structure of the chromosome, were compared among the Lyme disease spirochaetes. Differences were found in the sizes of the ospA-containing plasmids, but not the linear chromosome among the 3 species. The ospA-containing plasmid size of 50 kb in B. burgdorferi isolates is significantly smaller than the size of 55 kb in B. garinii isolates and 56 kb in group VS461 isolates. The chromosome was found to be linear in all 3 Borrelia species, but not significantly different in size. KW - biotechnology KW - chromosomes KW - DNA KW - genes KW - molecular genetics KW - plasmids KW - proteins KW - Borrelia KW - Borrelia afzelii KW - Borrelia burgdorferi KW - Borrelia garinii KW - Spirochaetaceae KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - outer-surface KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518591&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosomiasis: infection versus disease and hypersensitivity versus immunity. AU - Cheever, A. W. JO - American Journal of Pathology JF - American Journal of Pathology Y1 - 1993/// VL - 142 IS - 3 SP - 699 EP - 702 SN - 0002-9440 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803385. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Hepatic pathology in schistosomiasis is secondary to an immunologically mediated reaction to the ova. Infected persons who develop periportal fibrosis lack regulatory idiotypes present in individuals without such fibrosis. This article discusses current concepts of the pathogenesis of hepatic pathology in schistosomiasis with particular reference to the development of pipestem fibrosis in animal models. It then considers the host immune response to schistosome ova and the development of hepatic granulomata. Although prevention and control of schistosomal disease is usually based on reduction of the worm burden by chemotherapy, infection intensity might be more efficiently reduced by vaccination. With this in mind, immunity and the prospect of an anti-schistosomal vaccine are discussed. KW - fibrosis KW - granuloma KW - helminths KW - human diseases KW - hypersensitivity KW - immune response KW - immunity KW - immunization KW - immunology KW - immunopathology KW - inactivated vaccines KW - liver diseases KW - ova KW - parasites KW - pathology KW - reviews KW - Schistosomiasis KW - man KW - Schistosoma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - allergic responses KW - bilharzia KW - bilharziasis KW - hypersensitiveness KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - killed vaccines KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803385&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition. AU - Denkers, E. Y. AU - Sher, A. AU - Gazzinelli, R. T. JO - Research in Immunology JF - Research in Immunology Y1 - 1993/// VL - 144 IS - 1 SP - 51 EP - 57 SN - 0923-2494 AD - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930806005. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - The role of CD8+ T cells in immunity to Toxoplasma gondii is reviewed under the headings: role of interferon-γ; CD8+ cytolytic activity against infected host cells; hypotheses to explain dual requirement for interferon-γ and CD8+ cells; alternate entranceways into the class-I-restricted pathway of presentation. KW - Cytokines KW - Human diseases KW - immune response KW - immunology KW - Interferon KW - Major histocompatibility complex KW - parasites KW - Reviews KW - T lymphocytes KW - Apicomplexa KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - histocompatibility complex KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930806005&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulatory and immunopathological roles of IL4 in experimental schistosomiasis. AU - Oswald, I. P. AU - Wynn, T. A. AU - Williams, M. E. AU - Eltoum, I. AU - Cheever, A. W. AU - James, S. L. AU - Sher, A. JO - Research in Immunology JF - Research in Immunology Y1 - 1993/// VL - 144 IS - 8 SP - 643 EP - 648 SN - 0923-2494 AD - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950804316. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 207137-56-2. Subject Subsets: Helminthology N2 - The role of interleukin (IL)-4 during Schistosoma infection is reviewed, with reference to cytokine production during schistosomiasis, cellular sources of IL-4 in schistosome-infected animals, the role of IL-4 in Th2 cell response maturation, the immunopathological function of IL-4, and the down-regulatory influence of IL-4 on macrophage and endothelial cell effector functions. It is concluded that IL-4 has 3 major roles in schistosomiasis: it influences the development of the Th2 response; it participates in egg-induced pathology; and it is involved in the downregulation of cell-mediated immunity. Some of these functions appear to be beneficial to the parasite. KW - cytokines KW - helminths KW - human diseases KW - immune response KW - interleukin 4 KW - parasites KW - reviews KW - schistosomiasis KW - Digenea KW - Schistosoma KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes. AU - Denkers, E. Y. AU - Gazzinelli, R. T. AU - Hieny, S. AU - Caspar, P. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1993/// VL - 150 IS - 2 SP - 517 EP - 526 SN - 0022-1767 AD - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19930804388. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Protozoology N2 - It was shown that class I-transfected L cells differ from bone marrow macrophages (BMMØ) in that although both cell types are recognized cytolytic T lymphocytes after infection, only BMMØ are killed after sensitization with soluble tachyzoite extract. Gel filtration studies indicated that the T. gondii antigen responsible for sensitization of BMMØ are macromolecules with a MW ≥12 000. In contrast, peptides derived by tryptic digestion of this material were found to sensitize both transfected L cells and BMMØ. Although exogenous β2-microglobin markedly enhanced peptide sensitization of BMMØ, no such effect was observed using the macromolecular preparation. A requirement for cellular internalization in the processing by BMMØ of soluble antigen for class I-restricted recognition is suggested. In related experiments, infected and antigen-sensitized BMMØ were found to express cross-reactive T. gondii epitopes, as determined by cold target inhibition studies. Supernatant derived by 100 000 g centrifugation of tachyzoite extract had potent sensitizing activity, and after anion exchange chromatography most of the activity was associated with a single fraction. The p30 antigen was not detected by immunoblot analysis in the biologically active supernatant and chromatographic fractions. KW - Antibodies KW - Antigens KW - Bone marrow KW - Human diseases KW - immune response KW - Laboratory animals KW - Macrophages KW - parasites KW - Polypeptides KW - T lymphocytes KW - Apicomplexa KW - mice KW - Muridae KW - protozoa KW - Rodents KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804388&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma gondii induces a T-independent IFN-γ response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α. AU - Sher, A. AU - Oswald, I. P. AU - Hieny, S. AU - Gazzinelli, R. T. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1993/// VL - 150 IS - 9 SP - 3982 EP - 3989 SN - 0022-1767 AD - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804527. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Protozoology N2 - Spleen cells from scid mice produce high levels of IFN-γ when exposed to either live tachyzoites of Toxoplasma gondii or a soluble parasite extract. Small numbers of parasites are sufficient to stimulate this response, which is also induced by cell-free supernatants of cultured tachyzoites. The parasite molecules responsible for triggering IFN-γ production are heat-labile but resistant to freezing and thawing. Depletion of NK cells or adherent cells from the splenocyte population abolishes the response. Moreover, cultured bone marrow-derived NK cells are stimulated by Toxoplasma to produce IFN-γ, but only when supplemented with adherent peritoneal washout or thioglycollate-induced exudate cells. Supernatants of macrophages preincubated with T. gondii extract also induce IFN-γ synthesis by cultured NK cells. Addition of neutralizing MAb against TNF-α abolishes the IFN-γ response of scid spleen cells exposed to the parasite or of NK cells incubated with supernatants of adherent cells stimulated with T. gondii extract. Moreover, splenic adherent cells produce low levels of TNF-α in response to the parasite. Nevertheless, TNF-α alone is not sufficient to trigger IFN-γ production from purified NK cell populations. These findings provide the first example of the stimulation of T-independent IFN-γ production by a protozoan. The ability of T. gondii to trigger this pathway may underlie its induction of strong IFN-γ-dependent nonspecific and specific cell-mediated immunity. KW - cytokines KW - experimental infections KW - human diseases KW - immune response KW - interferon KW - laboratory animals KW - natural killer cells KW - parasites KW - tumour necrosis factor KW - Apicomplexa KW - mice KW - Muridae KW - protozoa KW - rodents KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - cachectin KW - cachexin KW - immunity reactions KW - immunological reactions KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804527&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of IL-5 in onchocerciasis. A critical role for IL-2. AU - Steel, C. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1993/// VL - 150 IS - 12 SP - 5511 EP - 5518 SN - 0022-1767 AD - Steel, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930808529. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2. Subject Subsets: Helminthology N2 - The cytokine profiles of peripheral blood mononuclear cells (PBMC) obtained from putatively immune individuals from an Onchocerca-endemic area of Guatemala were compared to those from Onchocerca volvulus infected individuals. The immune individuals had significantly higher levels of both interleukin-2 (IL-2) and IL-5 in response to parasite antigen than did individuals with active infection and there was a direct correlation between the production of IL-2 and IL-5. To examine the mechanism underlying the possible association between these 2 cytokines in patients infected with Onchocerca volvulus, reverse transcription and polymerase chain reaction were used to measure IL-5 mRNA. In response to recombinant IL-2, IL-5 RNA appeared 3 h after stimulation of patient PBMC, reaching a peak after 24 h. This response was inhibited with neutralizing antibodies to IL-2. IL-2 was unable to induce mRNA expression for IL-4, γ-interferon, IL-10 or granulocyte-macrophage-CSF. IL-5 mRNA expression was measured in PBMC stimulated with parasite antigen and was up-regulated in all patients (peaking at 72 h) independently of proliferation to antigen. This up-regulation was specifically inhibited by neutralizing anti-IL-2 antibodies. The primary source of IL-5 mRNA was determined to be CD4+ T cells. The findings suggest that IL-2 production is required to induce IL-5 and further implicates IL-5 as a possible mediator in onchocerciasis. KW - cytokines KW - helminths KW - human diseases KW - immune response KW - interferon KW - interleukin 10 KW - interleukin 2 KW - interleukin 5 KW - parasites KW - T lymphocytes KW - Central America KW - Guatemala KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - America KW - CACM KW - Central America KW - Developing Countries KW - Latin America KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930808529&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. AU - Wynn, T. A. AU - Eltoum, I. AU - Cheever, A. W. AU - Lewis, F. A. AU - Gause, W. C. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1993/// VL - 151 IS - 3 SP - 1430 EP - 1440 SN - 0022-1767 AD - Wynn, T. A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4/126, Bethesda, MD 20892, USA. N1 - Accession Number: 19930807929. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Helminthology N2 - Cytokine mRNA expression in lung tissue of C3H/HeN mice infected with 25 cercariae of Schistosoma mansoni (NMRI strain) was analyzed using a reverse transcriptase-polymerase chain reaction. Temporal analysis of mRNA expression in lung tissue containing synchronized granulomas demonstrated a Th0-like pattern of lymphokine expression. Interferon-(IFN)-γ, interleukin-(IL)-1β, and IL-6 were the primary cytokines induced, by day 1, in developing lung granulomas initiated by iv ovum injection. The changes were followed by increases in expression of IL-2, IL-4, and IL-10 mRNA on day 3 and TNF-α and IL-5 mRNA on day 6. Nearly all cytokine mRNA reached maximal levels by day 6, which preceded the peak in granuloma size seen on day 14. In vivo treatment of ovum-injected mice with either anti-IL-2 or anti-IL-4 antibodies significantly diminished the size of circumoval granulomas in the lungs. Both groups of antibody-treated animals displayed a marked reduction in IL-4 as well as IL-5 mRNA expression, although IFN-γ and IL-2 mRNA levels were unchanged or slightly increased. The findings confirm previous observations suggesting a role for IL-2 in ovum-induced pathology via the generation of Th2-associated responses, and also indicate a primary function for IL-4 in granuloma formation. Analysis of responses after injection of ova into C3H nude mice demonstrated that only the Th2 cytokines IL-4 and IL-5 are exclusively dependent on T cells for their induction. The data suggest that Th2 cells producing IL-4 play a major role in ovum granuloma formation, and that the induction and ultimate down-modulation of Th2-like responses may be influenced by non-T-cell-derived cytokines. KW - cytokines KW - developmental stages KW - experimental infections KW - granuloma KW - helminths KW - immune response KW - laboratory animals KW - parasites KW - T lymphocytes KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - growth phase KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807929&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preferential Vβ usage by cytotoxic T cells cross-reactive between two epitopes of HIV-1 gp160 and degenerate in class I MHC restriction. AU - Shirai, M. AU - Vacchio, M. S. AU - Hodes, R. J. AU - Berzofsky, J. A. JO - Journal of Immunology JF - Journal of Immunology Y1 - 1993/// VL - 151 IS - 4 SP - 2283 EP - 2295 AD - Shirai, M.: (J.A. Berzofsky) Molecular Immunogenesis & Vaccine Research Section, Metabolism Branch, Building 10, Room 6B-12, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004687. Publication Type: Journal Article. Language: English. Number of References: 64 ref. KW - cellular biology KW - cytotoxic T lymphocytes KW - envelope glycoproteins KW - Epitopes KW - HIV infections KW - Immunology KW - phenotypes KW - T lymphocytes KW - Antigen presentation KW - antigenic determinants KW - cell biology KW - human immunodeficiency virus infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004687&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Normal T cell receptor-mediated signaling in T cell lines stably expressing HIV-1 envelope glycoproteins. AU - Tani, Y. AU - Tian, H. AU - Lane, H. C. AU - Cohen, D. I. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1993/// VL - 151 IS - 12 SP - 7337 EP - 7348 SN - 0022-1767 AD - Tani, Y.: (D.I. Cohen) National Institutes of Health, Building 10, Rm 11B-13, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005172. Publication Type: Journal Article. Language: English. KW - human immunodeficiency viruses KW - Immunology KW - receptors KW - T lymphocytes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Env KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Signalling KW - T cells KW - Tat KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005172&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Summary of the 27th United States-Japan Joint Conference on Cholera and Related Diarrheal diseases. AU - Spriggs, D. R. AU - Guerrant, R. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 1 SP - 1 EP - 6 SN - 0022-1899 AD - Spriggs, D. R.: Enteric Diseases Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 3A-06, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022816. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - A report of the 27th annual meeting held in Charlottesville, Virginia, USA, on 25-27 September 1991. KW - Cholera KW - diarrhoea KW - cholera and related diarrhoeal diseases KW - diarrhea KW - scouring KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022816&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus (HIV) type 1 strain MN neutralizing antibody in HIV-infected children: correlation with clinical status and prognostic value. AU - Robert-Guroff, M. AU - Roilides, E. AU - et al. AU - Muldoon, R. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 3 SP - 538 EP - 546 SN - 0022-1899 AD - Robert-Guroff, M.: Laboratory of Tumor Cell Biology, Building 37, Room 6A15, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006821. Publication Type: Journal Article. Language: English. KW - Antibodies KW - Children KW - Clinical aspects KW - HIV infections KW - Immunity KW - Immunology KW - Prognosis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006821&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus. AU - Roilides, E. AU - Holmes, A. AU - Blake, C. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 4 SP - 905 EP - 911 SN - 0022-1899 AD - Roilides, E.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931214538. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The antifungal activity of neutrophils (PMNL) against hyphae of A. fumigatus in 31 HIV-infected children was assessed. Hyphal damage was unaffected in 15 HIV-infected children with age-adjusted CD4 cell counts ≥25% of the normal median value; it was decreased in 16 with CD4 cell counts <25% (both vs. 20 healthy controls, P=0.001). Incubation with sera from 12 of 14 HIV-infected children but not with the recombinant HIV proteins gp120, gp41 and p24 suppressed antifungal activity of normal PMNL compared with normal serum (P=0.002). Pretreatment of defective PMNL from 5 patients with granulocyte colony-stimulating factor (G-CSF) partially corrected the defect (P=0.002). It is suggested that impaired serum-mediated antifungal activity against Aspergillus hyphae exists in PMNL of HIV-infected patients with low CD4 cell counts and that G-CSF may improve this activity. KW - acquired immune deficiency syndrome KW - activity KW - antifungal agents KW - antimicrobial properties KW - Aspergillosis KW - children KW - HIV infections KW - immunology KW - neutrophils KW - Opportunistic infections KW - predisposition KW - Aspergillus fumigatus KW - man KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - AIDS KW - anti-microbial properties KW - fungistats KW - fungus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214538&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees. AU - Hall, S. L. AU - Sarris, C. M. AU - Tierney, E. L. AU - London, W. T. AU - Murphy, B. R. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 4 SP - 958 EP - 962 SN - 0022-1899 AD - Hall, S. L.: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932022621. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A live attenuated cold-adapted parainfluenza virus type 3 (PIV-3) vaccine is being developed to prevent the serious lower respiratory tract disease caused by this virus in infants and young children. This cold-passaged mutant (cp45) was evaluated in seronegative chimpanzees and found to be highly attenuated in both the upper and lower respiratory tracts compared to its wild-type parent. Animals immunized with cp45 were also highly resistant to wild-type PIV-3 challenge. Stability of the attenuation phenotype was demonstrated by the administration to 2 additional chimpanzees of an isolate of cp45 obtained after 10 days of replication in a chimpanzee. It was attenuated in both the upper and lower respiratory tracts. The cp45 virus present in the respiratory tract secretions of chimpanzees retained the temperature-sensitive (ts) phenotype, but some loss of ts property was observed in the isolates. These results provide a basis on which to proceed to clinical trials in seronegative human infants and children.AS KW - immunization KW - live vaccines KW - Parainfluenza KW - vaccines KW - chimpanzees KW - Pan KW - Pongidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Paramyxovirinae KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - attenuated and cold-adapted KW - attenuated vaccines KW - immune sensitization KW - parainfluenza 3 virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022621&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Racial differences in serum β2-microglobulin in persons with human immunodeficiency virus infection. AU - Lucey, D. R. AU - McCarthy, W. F. AU - Blatt, S. P. AU - Melcher, G. P. AU - Hendrix, C. W. T2 - Journal of Infectious Diseases JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 5 SP - 1259 EP - 1260 SN - 0022-1899 AD - Lucey, D. R.: Experimental Immunology Branch, Bldg 10, Room 4B17, NCI/National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004515. Publication Type: Correspondence. Language: English. Registry Number: 9066-69-7. KW - beta2-microglobulin KW - Disease markers KW - Ethnic groups KW - HIV infections KW - Pathology KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004515&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetics of serum and cellular interleukin-5 in posttreatment eosinophilia of patients with lymphatic filariasis. AU - Limaye, A. P. AU - Ottesen, E. A. AU - Kumaraswami, V. AU - Abrams, J. S. AU - Regunathan, J. AU - Vijayasekaran, V. AU - Jayaraman, K. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 6 SP - 1396 EP - 1400 SN - 0022-1899 AD - Limaye, A. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930804959. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 90-89-1, 1642-54-2. Subject Subsets: Helminthology; Tropical Diseases N2 - Peripheral blood eosinophil counts and serum levels and in vitro production of eosinophilopoietic cytokines were assessed before, and at frequent intervals after diethylcarbamazine treatment of Bancroftian filariasis in 15 men from Madras, India. Eosinophil counts peaked at day 7 after the start of treatment (359% ± 118% of pretreatment levels) and declined to pretreatment levels by day 17. Serum interleukin (IL-5), undetectable in 14 patients before treatment, rose sharply but transiently, with peak levels (32 ± 7 pg/ml) 2 days after diethylcarbamazine treatment. Granulocyte-macrophage colony-stimulating factor and IL-3 were not detectable in serum at any time. In vitro mitogen-induced IL-5 levels decreased significantly in 7 of 9 patients 3 days after treatment when serum IL-5 was at near-peak levels. By day 10 IL-5 values increased in 8 of 9 patients compared with treatment values. These data define a temporal relationship between serum IL-5 levels and the subsequent development of eosinophilia and suggest that lymphocytes are the source of IL-5. KW - Cytokines KW - diethylcarbamazine KW - drug therapy KW - Eosinophilia KW - Eosinophils KW - Filariasis KW - helminths KW - Human diseases KW - immune response KW - infections KW - Interleukins KW - parasites KW - Asia KW - India KW - Tamil Nadu KW - man KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Wuchereria KW - Onchocercidae KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - chemotherapy KW - eosinophil leukocytes KW - immunity reactions KW - immunological reactions KW - Madras KW - nematodes KW - parasitic worms KW - posttreatment eosinophilia KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804959&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS. AU - Masur, H. AU - Polis, M. A. AU - Tuazon, C. U. AU - Ogata-Arakaki, D. AU - Kovacs, J. A. AU - Katz, D. AU - Hilt, D. AU - Simmons, T. AU - Feuerstein, I. AU - Lundgren, B. AU - Lane, H. C. AU - Chabner, B. A. AU - Allegra, C. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 167 IS - 6 SP - 1422 EP - 1426 SN - 0022-1899 AD - Masur, H.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930804961. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 58-05-9, 52128-35-5. Subject Subsets: Protozoology N2 - The clinical efficacy of trimetrexate, a dihydrofolate reductase inhibitor reported to have potent in vitro antitoxoplasma activity, was associated in 9 sulfonamide-intolerant patients with AIDS and biopsy-proven cerebral toxoplasmosis. The 9 patients were treated for 28-149 days with trimetrexate (30-280 mg/m²/day) plus leucovorin (20-90 mg/m² every 6 h). Radiographic responses were documented in 8 patients, and clinical responses in 5 patients. Despite continued therapy, all patients deteriorated clinically and radiographically within 13-109 days of their initial improvement. Trimetrexate at very high doses for extended periods was not associated with serious toxicity. Trimetrexate alone had dramatic but transient activity in sulfonamide-intolerant patients and thus is not adequate as single-agent therapy for AIDS-associated toxoplasmosis. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Antiprotozoal agents KW - Brain KW - brain diseases KW - clinical aspects KW - Drug combinations KW - drug therapy KW - Efficacy KW - FOLINIC ACID KW - Human diseases KW - human immunodeficiency viruses KW - Immunocompromised hosts KW - Opportunistic infections KW - parasites KW - toxoplasmosis KW - Treatment KW - Trimetrexate KW - Maryland KW - North America KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - brain disorders KW - cerebrum KW - chemotherapy KW - citrovorum factor KW - clinical picture KW - human immunodeficiency virus KW - leucovorin KW - Trimetraxate-leucovorin KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804961&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Albendazole in human loiasis: results of a double-blind, placebo-controlled trial. AU - Klion, A. D. AU - Massougbodji, A. AU - Horton, J. AU - Ekoué, S. AU - Lanmasso, T. AU - Ahouissou, N. L. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 1 SP - 202 EP - 206 SN - 0022-1899 AD - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19930805488. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 54965-21-8. Subject Subsets: Helminthology N2 - To assess the filaricidal activity and clinical safety of albendazole in human loiasis, a double-blind, placebo-controlled study was conducted in an endemic area in Benin, Africa. 23 men with microfilaraemia (100-30 000/ml) were randomly assigned to receive albendazole (200 mg; n = 11) or placebo (n = 12) twice daily for 21 days; 1 patient from each group withdrew from the study. There were no clinical adverse effects and no observed hepatotoxicity, renal toxicity, or haematologic abnormalities attributable to the drug. In the albendazole group, microfilarial levels began to decrease at day 14 after treatment and by 6 months had fallen to a geometric mean of 20% of pretreatment levels (vs. 84.8% in the placebo group). Blood eosinophil levels and anti-filarial IgG and IgG4 also fell significantly in response to albendazole. Taken together, these data suggest that albendazole has a primary (possibly embryotoxic) effect on the adult parasite, resulting in a slow decrease in microfilaraemia. KW - Albendazole KW - Anthelmintics KW - drug therapy KW - Filariasis KW - helminths KW - Human diseases KW - Loiasis KW - parasites KW - Africa KW - Benin KW - Loa loa KW - man KW - Nematoda KW - Onchocercidae KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - ACP Countries KW - Francophone Africa KW - Africa KW - Least Developed Countries KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - African eyeworm KW - chemotherapy KW - Dahomey KW - loaosis KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930805488&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice. AU - Taller, A. M. AU - Xiao, S. Y. AU - et al. AU - Godec, M. S. ( AU - Asher, D. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 3 SP - 750 EP - 753 SN - 0022-1899 AD - Taller, A. M.: (D.M. Asher) National Institutes of Health, Bldg. 36, Rm. 5B21, Bethesda, MD 20892, USA. N1 - Accession Number: 19942025542. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Belgrade virus is a recently described hantavirus that causes severe hemorrhagic fever with renal syndrome (HFRS) in people living in various parts of the Balkan Peninsula. Nucleotide sequencing of the G2-encoding region in the medium (M) segment of the viral genome, reverse transcribed and amplified by the polymerase chain reaction, revealed the Belgrade virus to be substantially different from Hantaan virus and other major serotypes of hantavirus but identical to Dobrava virus, a virus isolated from a field mouse (Apodemus flavicollis) in Slovenia. Belgrade virus may be an important cause of HFRS in the Balkan Peninsula, extending north toward the Alps. It poses a special danger to humans who have close contact with field rodents. AS KW - characterization KW - Belgrade virus KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025542&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A pilot study of sequential therapy with zidovudine plus acyclovir, dideoxyinosine, and dideoxycytidine in patients with severe human immunodeficiency virus infection. AU - Nguyen, B. Y. T. AU - Shay, L. E. AU - et al. AU - Wyvill, K. M. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 4 SP - 810 EP - 817 SN - 0022-1899 AD - Nguyen, B. Y. T.: Bldg 10, Rm 12N226, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942004878. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 59277-89-3, 69655-05-6, 7841-89-2, 30516-87-1. KW - aciclovir KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - didanosine KW - Dideoxycytidine KW - HIV infections KW - Treatment KW - Zidovudine KW - acyclovir KW - AIDS KW - AZT KW - Combination drugs KW - dideoxyinosine KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942004878&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of a recombinant CD4-IgG on in vitro T helper cell function: data from a phase I/II study of patients with AIDS. AU - Clerici, M. AU - Yarchoan, R. AU - et al. AU - Blatt, S. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 4 SP - 1012 EP - 1016 SN - 0022-1899 AD - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, Building 10, Rm 4B-17, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942004883. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - HIV infections KW - Treatment KW - AIDS KW - human immunodeficiency virus infections KW - Recombinant CD4 immunoglobulin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942004883&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytomegalovirus infection and risk of AIDS in human immunodeficiency virus-infected hemophilia patients. AU - Rabkin, C. S. AU - Hatzakis, A. AU - et al. AU - Griffiths, P. D. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 5 SP - 1260 EP - 1263 SN - 0022-1899 AD - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, EPN/434, Rockville, MD 20852, USA. N1 - Accession Number: 19942005123. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - disease course KW - haemophilia KW - HIV infections KW - Opportunistic infections KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - AIDS KW - disease progression KW - hemophilia KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High prevalence of hepatitis C virus (HCV) RNA in dialysis patients: failure of commercially available antibody tests to identify a significant number of patients with HCV infection. AU - Bukh, J. AU - Wantzin, P. AU - Krogsgaard, K. AU - Knudsen, F. AU - Purcell, R. H. AU - Miller, R. H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 6 SP - 1343 EP - 1348 SN - 0022-1899 AD - Bukh, J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 7, Room 201, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028259. Publication Type: Journal Article. Corporate Author: Denmark, Copenhagen Dialysis HCV Study Group. Language: English. Subject Subsets: Public Health N2 - Results of serologic tests were correlated with hepatitis C virus (HCV) viraemia, determined by a cDNA polymerase chain reaction assay to detect HCV RNA, in 340 Danish dialysis patients; of these, 28 (8.2%) were positive for antibodies to HCV (anti-HCV) with second-generation ELISAs. HCV RNA was found in sera from 27 of these 28 anti-HCV-positive patients. However, 8 dialysis patients had detectable levels of HCV RNA but were anti-HCV-negative with second-generation ELISAs. Among the 35 HCV-infected dialysis patients 16 were positive, 7 indeterminate, and 12 negative with the second-generation RIBA. More than 60% of patients with evidence of ongoing liver disease had HCV infection. Thus, current commercially available antibody tests did not accurately reflect the HCV status in dialysis patients. A relatively high prevalence (>10%) of HCV RNA, closely associated with liver disease, was found among dialysis patients in a low-prevalence area of the world. AS KW - diagnosis KW - dialysis KW - ELISA KW - failure KW - Hepatitis C KW - patients KW - Denmark KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - enzyme linked immunosorbent assay KW - prevalence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028259&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type 1 disease: relationships to clinical status and therapeutic response. AU - Brouwers, P. AU - Heyes, M. P. AU - et al. AU - Moss, H. A. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 6 SP - 1380 EP - 1386 SN - 0022-1899 AD - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Center, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005270. Publication Type: Journal Article. Language: English. KW - Cerebrospinal fluid KW - Disease markers KW - HIV infections KW - Paediatrics KW - human immunodeficiency virus infections KW - pediatrics KW - Quinolinic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Congenital yellow fever virus infection after immunization in pregnancy. AU - Tsai, T. F. AU - Paul, R. AU - Lynberg, M. C. AU - Letson, G. W. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 6 SP - 1520 EP - 1523 SN - 0022-1899 AD - Tsai, T. F.: Clinical Microbiology Service, Bldg. 10 2C-385, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028293. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - To determine whether yellow fever (YF) vaccine administered in pregnancy causes fetal infection, [47] women who were vaccinated during unrecognized pregnancy in a mass campaign in Trinidad were studied retrospectively. Maternal and cord or infant blood were tested for IgM and neutralizing antibodies to YF and dengue viruses. One of 41 infants had IgM and elevated neutralizing antibodies to YF virus, indicating congenital infection. The infant, the first reported case of YF virus infection after immunization in pregnancy, was delivered after an uncomplicated full-term pregnancy and appeared normal. Congenital dengue 1 infection may have occurred in another case. The frequency of fetal infection and adverse events after such exposure could not be estimated; however, the neurotropism of YF virus for the developing nervous system and the now documented possibility of transplacental infection underscores the admonition that YF vaccination in pregnancy should be avoided.AS<new para>ADDITIONAL ABSTRACT:<new para>To determine whether yellow fever (YF) vaccines administered in pregnancy causes fetal infection, women who were vaccinated during unrecognized pregnancy in a mass campaign in Trinidad were studied retrospectively. Maternal and cord or infant blood were tested for IgM and neutralizing antibodies to YF and dengue viruses. 1 of 41 infants had IgM and elevated neutralizing antibodies to YF viruses, indicating congenital infection. The infant, the first reported case of YF virus infection after immunization in pregnancy, was delivered after an uncomplicated full-term pregnancy and appeared normal. Congenital dengue 1 infection may have occurred in another case. The frequency of fetal infection and adverse events after such exposure could not be estimated; however, the neurotropism of YF virus for the developing nervous system and the now documented possibility of transplacental infection underscores the admonition that YF vaccination in pregnancy should be avoided. KW - arboviruses KW - case reports KW - congenital infection KW - human diseases KW - immunization KW - pregnancy KW - vaccination KW - women KW - Yellow fever KW - Caribbean KW - Trinidad and Tobago KW - dengue virus KW - Flavivirus KW - man KW - yellow fever virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Lesser Antilles KW - Antilles KW - Caribbean KW - Threshold Countries KW - arthropod-borne viruses KW - gestation KW - immune sensitization KW - prenatal infection KW - Trinidad & Tobago KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028293&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Defective antifungal activity of monocyte-derived macrophages from human immunodeficiency virus-infected children against Aspergillus fumigatus. AU - Roilides, E. AU - Holmes, A. AU - Blake, C. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1993/// VL - 168 IS - 6 SP - 1562 EP - 1565 SN - 0022-1899 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200374. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - The antifungal activity against A. fumigatus of peripheral blood monocyte-derived macrophages (MDM) from 19 HIV-positive children from Maryland, USA, was compared with that of 16 normal controls. The phagocytic activity of patients' MDM, measured as percentage of phagocytosis, was significantly decreased compared with normal subjects (P=0.014). The inhibitory activity of MDM on germination of intracellular A. fumigatus conidia was significantly impaired in patients compared with normal controls (P=0.016). There was no significant difference in the defects between patients with lower or higher CD4 lymphocyte counts. It is suggested that impairment of antifungal activity of macrophages may contribute to the susceptibility of HIV-infected patients to aspergillosis.<new para>ADDITIONAL ABSTRACT:<new para>... The antifungal activity of peripheral blood monocyte-derived macrophages (MDM) from 19 HIV-infected children was compared with that of 16 normal controls. The phagocytic activity of patients' MDM, measured as percentage of phagocytosis, was significantly decreased compared with normal donors (P = 0.014). In addition, the inhibitory activity of MDM on germination of intracellular Aspergillus fumigatus conidia was significantly impaired in patients compared with normal controls (P = 0.016). There was no significant difference in the defects between patients with lower or higher CD4 lymphocyte counts. Impairment of antifungal activity of macrophages may contribute to the susceptibility of HIV-infected patients to aspergillosis. AS KW - acquired immune deficiency syndrome KW - activity KW - antifungal agents KW - antimicrobial properties KW - aspergillosis KW - children KW - Clinical aspects KW - defects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunology KW - infections KW - macrophages KW - opportunistic infections KW - Paediatrics KW - predisposition KW - Maryland KW - North America KW - USA KW - Aspergillus fumigatus KW - man KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - anti-microbial properties KW - clinical picture KW - fungistats KW - fungus KW - HIV patients KW - Human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - pediatrics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. AU - Marconi, R. T. AU - Samuels, D. S. AU - Garon, C. F. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1993/// VL - 175 IS - 4 SP - 926 EP - 932 SN - 0021-9193 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19940500333. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - In Lyme disease spirochaetes, the ospC gene encodes a 22.7-kDa protein referred to as either the pC or the OspC protein. Using a variety of electrophoretic approaches followed by Southern blotting and probing with oligonucleotide probes, the ospC gene to a circular 26-kb plasmid was mapped. The ospC gene represents the first gene to be mapped to a circular plasmid in Lyme disease spirochaetes. The occurrence of this gene in isolates belonging to each of the 3 Lyme disease-associated species, Borrelia burgdorferi, B. garinii and the VS461 group [B.afzelii], was evaluated. The ospC gene was found to occur in all 21 isolates tested from each of the 3 species. Differential hybridization with a series of ospC probes in both Northern (RNA) and Southern blot analyses demonstrated that there is sequence variability in the ospC gene among isolates. While the gene was found to be present in all isolates, not all actively transcribed the gene. Transcriptional start site analyses suggested that the gene may be under the control of multiple promoters that are highly similar in nucleotide sequence. KW - antigens KW - biotechnology KW - DNA hybridization KW - gene mapping KW - genes KW - immunoblotting KW - molecular genetics KW - nucleotide sequences KW - proteins KW - transcription KW - Borrelia afzelii KW - Borrelia burgdorferi KW - Borrelia garinii KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - biochemical genetics KW - DNA sequences KW - DNA transcription KW - immunogens KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940500333&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Abnormal in vitro proliferation and differentiation of T cell colony-forming cells in patients with tropical spastic paraparesis/human T lymphocyte virus type I (HTLV-I)-associated myeloencephalopathy and healthy HTLV-I carriers. AU - Lunardi-Iskandar, Y. AU - Gessain, A. AU - Lam, V. H. AU - Gallo, R. C. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1993/// VL - 177 IS - 3 SP - 741 EP - 750 SN - 0022-1007 AD - Lunardi-Iskandar, Y.: (R.C. Gallo) Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm 6A09, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932023461. Publication Type: Journal Article. Language: English. KW - cellular biology KW - HTLV infections KW - Immune response KW - Immunology KW - Pathogenesis KW - T lymphocytes KW - cell biology KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - immunity reactions KW - immunological reactions KW - Proliferation KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023461&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High human T cell lymphoctropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. AU - Elovaara, I. AU - Koenig, S. AU - Brewah, A. Y. AU - Woods, R. M. AU - Lehky, T. AU - Jacobson, S. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1993/// VL - 177 IS - 3 SP - 1567 EP - 1573 SN - 0022-1007 AD - Elovaara, I.: Neuroimmunology Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051324. Publication Type: Journal Article. Language: English. KW - cytotoxic T lymphocytes KW - HTLV-I infections KW - myelopathy KW - tropical spastic paraparesis KW - pathogeneis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051324&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selection of rabbit CD4-CD8- T cell receptor-γ/δ cells by in vitro transformation with human T lymphotropic virus-I. AU - Sawasdikosol, S. AU - Hague, B. F. AU - et al. AU - Zhao, T. M. ( JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1993/// VL - 178 IS - 4 SP - 1337 EP - 1345 SN - 0022-1007 AD - Sawasdikosol, S.: (T.J. Kindt) Laboratory of Immunogenetics, NIAID Twinbrook II Facility, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA. N1 - Accession Number: 19942006745. Publication Type: Journal Article. Language: English. KW - Animal models KW - Experimental infections KW - Immunology KW - Deltaretrovirus KW - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE I KW - Rabbits KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emergence of NK1.1+ cells as effectors of IFN-γ dependent immunity to Toxoplasma gondii in MHC class I-deficient mice. AU - Denkers, E. Y. AU - Gazzinelli, R. T. AU - Martin, D. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1993/// VL - 178 IS - 5 SP - 1465 EP - 1472 SN - 0022-1007 AD - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950807815. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9008-11-1. Subject Subsets: Tropical Diseases N2 - In order to assess the role of CD8+ cells in resistance against Toxoplasma gondii, the ability of β2m-deficient mice to survive tachyzoite challenge following vaccination with an attenuated parasite mutant was studied. Vaccination of these mice induced strong resistance to lethal challenge, with >50% surviving beyond 3 months. Vaccinated β2m-deficient mice, but not control heterozygotes, showed a 5- to 6-fold expansion in spleen cell number and ~40% of the splenocytes were found to express the NK markers NK1.1 and asialo GM1. Spleen cells from the vaccinated mice failed to kill either infected host cells or the NK target YAC-1. However, high levels of interferon-γ (IFN-γ) were secreted when the cells were cultured in vitro with soluble T. gondii lysate, and this response was abolished by NK1.1+ but not CD4+ and CD8+ lymphocyte depletion, implicating the NK1.1+ as the major source of IFN-γ. More importantly, vaccine-induced immunity in these mice was completely abrogated by in vivo administration of antibody to NK1.1, asialo GM1, or IFN-γ. These data suggest that in class-I deficient mice vaccinated against T. gondii, the absence of CD8+ cells is compensated for by the emergence of a population of NK1.1+ and asialo GM1 cells which lack cytolytic activity, and that the protective action of these cells against the parasite is attributable to IFN-γ. KW - cell mediated immunity KW - experimental infections KW - immune response KW - immunity KW - immunization KW - immunology KW - in vitro KW - interferon KW - laboratory animals KW - natural killer cells KW - T lymphocytes KW - tachyzoites KW - Toxoplasmosis KW - mice KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - cellular immunity KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807815&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. AU - Stanley, S. K. AU - McCune, J. M. AU - et al. AU - Kaneshima, H. ( JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1993/// VL - 178 SP - 1151 EP - 1163 SN - 0022-1007 AD - Stanley, S. K.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, room 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006792. Publication Type: Journal Article. Language: English. KW - CD4+ lymphocytes KW - CD8+ lymphocytes KW - HIV infections KW - Immunology KW - Immunosuppression KW - thymus gland KW - Mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4+ cells KW - CD8+ cells KW - human immunodeficiency virus infections KW - T4 lymphocytes KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006792&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analogues of butyric acid that increase the expression of transfected DNAs. AU - Carstea, E. D. AU - Miller, S. P. F. AU - Christakis, H. AU - O'Neill, R. R. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1993/// VL - 192 IS - 2 SP - 649 EP - 656 SN - 0006-291X AD - Carstea, E. D.: Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, Building 10, Room 3D-04, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940102741. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 107-92-6. Subject Subsets: Agricultural Biotechnology N2 - 14 analogues of butryic acid were screened for the ability to upregulate expression of 3 chloramphenicol acetyl transferase (CAT) vectors stably integrated into NIH 3T3 cells. Butyric acid, 2-bromobutyric acid, 3-bromopropionic acid, 3-mercaptopropionic acid, vinylacetic acid and butyraldehyde upregulated the human immunodeficiency virus long terminal repeat, the simian virus 40 early promoter and glucocerebrosidase promoter-directed gene expression in the cultured cells. KW - analogues KW - biotechnology KW - butyric acid KW - cell lines KW - gene expression KW - human immunodeficiency viruses KW - promoters KW - recombinant DNA KW - mammals KW - simian virus 40 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - simian polyomaviruses KW - analogs KW - butanoic acid KW - enhancement KW - glucocerebrosidase KW - human immunodeficiency virus KW - promoter region KW - promoter sequences KW - upregulation KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940102741&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro infection of human bone marrow by feline leukemia viruses. AU - Morgan, R. A. AU - Dornsife, R. E. AU - French Anderson, W. AU - Hoover, E. A. JO - Virology (New York) JF - Virology (New York) Y1 - 1993/// VL - 193 IS - 1 SP - 439 EP - 442 SN - 0042-6822 AD - Morgan, R. A.: Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952206004. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science N2 - About 5 to 10% of the bulk human marrow culture could be infected by feline leukaemia virus. KW - feline leukaemia KW - cats KW - Gammaretrovirus KW - man KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - feline leukemia KW - feline leukosis KW - feline oncovirus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952206004&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Niemann-Pick C disease: cystine and lipids accumulate in the murine model of this lysosomal cholesterol lipidosis. AU - Butler, J. D. AU - Vanier, M. T. AU - Pentchev, P. G. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1993/// VL - 196 IS - 1 SP - 154 EP - 159 SN - 0006-291X AD - Butler, J. D.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 10 Rm.10N308, Bethesda, MD 20892, USA. N1 - Accession Number: 19951403443. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 57-88-5, 56-89-3. Subject Subsets: Animal Nutrition; Human Nutrition N2 - Cystine values in tissues of the BALB/C mouse model of type C Niemann-Pick disease were greatly increased. Subcellular fractionation of liver homogenates by differential centrifugation suggested preferential accumulation in a fraction corresponding to lysosomes. Developmentally, a sharp increase in the accumulation of cystine in the mutant mouse liver occurs subsequent to a similar change in the accumulation of cholesterol, sphingomyelin and glucocerebroside. The lysosomal accumulation of cystine in this mutant mouse provides the experimental opportunity to study some aspects of the deficiency of lysosomal transport noted in cystinosis. KW - animal models KW - cholesterol KW - cystine KW - lipidosis KW - lipids KW - liver KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - lipins KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403443&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells. AU - Saunders, N. A. AU - Smith, R. J. AU - Jetten, A. M. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1993/// VL - 197 IS - 1 SP - 46 EP - 54 SN - 0006-291X AD - Saunders, N. A.: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19940404040. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9007-49-2. Subject Subsets: Dairy Science KW - differentiation KW - DNA KW - epithelium KW - genes KW - mammary glands KW - nucleic acids KW - regulation KW - senescence KW - tissue proliferation KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - proliferative disorders KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940404040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spontaneous and inducible epidermal hyperlasia in transgenic mice expressing HIV-1 Nef. AU - Dickie, P. AU - Ramsdell, F. AU - Notkins, A. L. AU - Venkatesan, S. JO - Virology (New York) JF - Virology (New York) Y1 - 1993/// VL - 197 IS - 1 SP - 431 EP - 438 SN - 0042-6822 AD - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases. N1 - Accession Number: 19952009816. Publication Type: Journal Article. Language: English. N2 - In HIV/Nef transgenic mouse lines, nef expression was detected exclusively in the skin and a significant fraction of HIV/Nef transgenic animals (30-75%, depending on the line) spontaneously developed discrete proliferative skin lesions resembling papillomas that were often accompanied by a progressive ulceration of the epidermal cell layer. Nef protein was detected in the basal cell layer of the epidermis and was elevated in the proliferating epidermis. Epidermal cell proliferation could be induced by UV-C irradiation of HIV/Nef transgenic animals but not control mice. An increase in nef expression in the skin accompanied this proliferation. MMTV/Nef mouse lines expressed Nef RNA and protein in organs typically permissive for MMTV LTR-directed transcription but with no obvious pathological consequence. KW - genetically engineered organisms KW - human diseases KW - transgenic animals KW - Human immunodeficiency virus 1 KW - man KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GMOs KW - human immunodeficiency virus type 1 KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009816&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Rev-mediated HIV-1 expression by an RNA binding protein encoded by the interferon-inducible 9-27 gene. AU - Constantoulakis, P. AU - Campbell, M. AU - Felber, B. K. AU - Nasioulas, G. AU - Afonina, E. AU - Pavlakis, G. N. JO - Science, USA JF - Science, USA Y1 - 1993/// VL - 259 IS - Feb. 26 SP - 1314 EP - 1318 AD - Constantoulakis, P.: (G.N. Pavlakis) Human Retrovirus Section, National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702, USA. N1 - Accession Number: 19932020566. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 9008-11-1. KW - cellular biology KW - Gene expression KW - human immunodeficiency viruses KW - Interferon KW - Molecular biology KW - Regulation KW - Transcription KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cell biology KW - DNA transcription KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Post-transcription KW - Rev KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020566&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of the von Hippel-Lindau disease tumor suppressor gene. AU - Latif, F. AU - Tory, K. AU - Gnarra, J. AU - Yao, M. AU - Duh, F. M. AU - Orcutt, M. L. AU - Stackhouse, T. AU - Kuzmin, I. AU - Modi, W. AU - Geil, L. AU - Schmidt, L. AU - Zhou, F. W. AU - Li, H. AU - Wei, M. H. AU - Chen, F. AU - Glenn, G. AU - Choyke, P. AU - Walther, M. M. AU - Weng, Y. K. AU - Duan, D. S. R. AU - Dean, M. AU - Glavač, D. AU - Richards, F. M. AU - Crossey, P. A. AU - Ferguson-Smith, M. A. AU - Le Paslier, D.\Chumakov, I.\Cohen, D.\Chinault, A. C.\Maher, E. R.\Marston Linehan, W.\Zbar, B.\Lerman, M. I. JO - Science (Washington) JF - Science (Washington) Y1 - 1993/// VL - 260 IS - 5112 SP - 1317 EP - 1320 SN - 0036-8075 AD - Latif, F.: Laboratory of Immunobiology, National Cancer Institute - Frederick Cancer Research and Development Center (NCI-FCRDC), Frederick, MD 21702-1201, USA. N1 - Accession Number: 19950806150. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology N2 - A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. The VHL gene is evolutionarily conserved and encodes two widely expressed transcripts of approximately 6 and 6.5 kilobases. The partial sequence of the inferred gene product shows no homology to other proteins, except for an acidic repeat domain found in the procyclic surface membrane glycoprotein of Trypanosoma brucei. KW - genes KW - kidney diseases KW - molecular genetics KW - neoplasms KW - nucleotide sequences KW - parasites KW - protozoa KW - Trypanosoma brucei KW - invertebrates KW - animals KW - eukaryotes KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - biochemical genetics KW - cancers KW - cloning KW - DNA sequences KW - kidney disorders KW - nephropathy KW - renal diseases KW - von Hippel-Lindau disease tumour suppressor gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806150&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A linkage between DNA markers on the X chromosome and male sexual orientation. AU - Hamer, D. H. AU - Hu, S. AU - Magnuson, V. L. AU - Hu, N. AU - Pattatucci, A. M. L. JO - Science, USA JF - Science, USA Y1 - 1993/// VL - 261 IS - July 16 SP - 321 EP - 327 AD - Hamer, D. H.: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004604. Publication Type: Journal Article. Language: English. KW - genes KW - Homosexuality KW - human immunodeficiency viruses KW - sociology KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - homosexuals KW - HUMAN IMMUNODEFICIENCY VIRUS KW - social aspects KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004604&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a. AU - Lei, K. J. AU - Shelly, L. L. AU - Pan, C. J. AU - Sidbury, J. B. AU - Chou, J. Y. JO - Science (Washington) JF - Science (Washington) Y1 - 1993/// VL - 262 IS - 5133 SP - 580 EP - 583 SN - 0036-8075 AD - Lei, K. J.: Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941404472. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9001-39-2. Subject Subsets: Human Nutrition N2 - Glycogen storage disease type 1a is caused by deficiency of D-glucose-6-phosphatase (G6Pase), the key enzyme in glucose homeostasis. Despite both a high incidence and morbidity, the molecular mechanisms underlying this deficiency have eluded characterisation. In this study, the molecular and biochemical characterisation of the human G6Pase complementary DNA, its gene and the expressed protein, which is indistinguishable from human microsomal G6Pase, are reported. Several mutations in the G6Pase gene of affected individuals that completely inactivate the enzyme have been identified. The results establish the molecular basis of this disease and open the way for future gene therapy. KW - deficiency KW - genetic disorders KW - glucose-6-phosphatase KW - glycogenosis KW - molecular biology KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic defects KW - glycogen disease KW - glycogen storage disease KW - glycogenic hepatomegaly KW - hereditary defects KW - Pompe's disease KW - Von Gierke's disease KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404472&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pyruvate and lactate metabolism in the in vivo dog heart. AU - Laughlin, M. R. AU - Taylor, J. AU - Chesnik, A. S. AU - DeGroot, M. AU - Balaban, R. S. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1993/// VL - 264 IS - 6, 2 SP - H2068 EP - H2079 SN - 0002-9513 AD - Laughlin, M. R.: Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941405348. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 56-65-5, 50-21-5, 127-17-3. Subject Subsets: Human Nutrition N2 - The extraction, intracellular carbon, and high energy phosphate metabolism of lactate and pyruvate were measured in vivo in the dog heart. Pyruvate fractional extraction exceeded that of lactate by a factor of 5, and elevated pyruvate severely reduced the net uptake of lactate but not its transport into the cell. Pyruvate also inhibited myocardial lactate dehydrogenase, and lactate relieved this inhibition. Both substrates suppressed oxidation of other molecules and caused intracellular free magnesium to decrease but did not alter work output or O2 extraction. Pyruvate, but not lactate, resulted in a decrease in adenosine diphosphate and an elevated phosphorylation potential. The change in phosphorylation potential is therefore due to a cytosolic event, most likely the redox state. The data indicate that the phosphorylation potential of the heart is a function of the cytosolic as well as mitochondrial energy state, and that this can be manipulated in vivo by choice of substrate. KW - ATP KW - heart KW - lactic acid KW - metabolism KW - pyruvic acid KW - dogs KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adenosine triphosphate KW - lactate KW - pyruvate KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405348&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of adenosine antagonists on hexose uptake and preconditioning in perfused rat heart. AU - Murphy, E. AU - Fralix, T. A. AU - London, R. E. AU - Steenbergen, C. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1993/// VL - 265 IS - 4 SP - C1146 EP - C1155 SN - 0002-9513 AD - Murphy, E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19951407750. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 58-61-7. Subject Subsets: Human Nutrition; Animal Nutrition KW - adenosine KW - antagonists KW - heart KW - hexoses KW - metabolism KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407750&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification. AU - Ziegelstein, R. C. AU - Cheng, L. AU - Blank, P. S. AU - Spurgeon, H. A. AU - Lakatta, E. G. AU - Hansford, R. G. AU - Capogrossi, M. C. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1993/// VL - 265 IS - 4 SP - H1424 EP - H1433 SN - 0002-9513 AD - Ziegelstein, R. C.: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore 21224, USA. N1 - Accession Number: 19951407745. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition; Animal Nutrition KW - acid base equilibrium KW - acidosis KW - calcium KW - cell cultures KW - endothelium KW - homeostasis KW - pH KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hydrogen ion concentration KW - metabolic acidosis KW - potential of hydrogen KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. AU - Kovacs, J. A. AU - Powell, F. AU - Edman, J. C. AU - Lundgren, B. AU - Martinez, A. AU - Drew, B. AU - Angus, C. W. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1993/// VL - 268 IS - 8 SP - 6034 EP - 6040 SN - 0021-9258 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931251633. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - Seven related but unique genes encoding the major surface glycoprotein of rat P. carinii were cloned and sequenced. Partial amino acid sequencing confirmed the identity of these genes. Based on Southern blot studies using chromosomal or restricted DNA, the major surface glycoproteins are the products of a multicopy family of genes. The predicted protein has an Mr of approx. 123 000, is relatively rich in cysteine residues (5.5%) that are very strongly conserved, and contains a well conserved hydrophobic region at the carboxyl terminus. It is concluded that the presence of multiple related msg genes encoding the major surface glycoprotein of P. carinii indicates that antigenic variation is a possible mechanism for evading host defences. KW - antigens KW - DNA sequencing KW - genes KW - genetics KW - glycoproteins KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunology KW - Molecular biology KW - molecular genetics KW - nucleotide sequences KW - opportunistic infections KW - parasites KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - invertebrates KW - animals KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - fungus KW - HUMAN IMMUNODEFICIENCY VIRUS KW - immunogens KW - Major surface glycoprotein KW - nucleotide sequence analysis KW - nucleotide sequencing KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251633&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Autophosphorylation-independent activation of Acanthamoeba myosin I heavy chain kinase by plasma membranes. AU - Kulesza-Lipka, D. AU - Brzeska, H. AU - Baines, I. C. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1993/// VL - 268 IS - 24 SP - 17995 EP - 18001 SN - 0021-9258 AD - Kulesza-Lipka, D.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805410. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Protozoology N2 - The 3 isoforms of Acanthamoeba castellanii myosin I (non-filamentous myosin with only a single heavy chain) express actin-activated Mg2+-ATPase activity only when phosphorylated at a single site by myosin I heavy chain kinase. The kinase is activated by autophosphorylation that is greatly stimulated by acidic phospholipids. Substantial fractions of the 3 myosins I and the kinase are associated in situ with membranes, and all 4 enzymes bind to purified membranes in vitro. It is reported that when kinase and myosin I are incubated together with phosphatidylserine vesicles, not only does the kinase autophosphorylate more rapidly than soluble kinase in the absence of phosphatidylserine but that, probably as a result, the kinase phosphorylates myosin I more rapidly than soluble kinase phosphorylates soluble myosin I. Similarly, plasma membrane-bound kinase phosphorylates membrane-bound myosin I and activates its actin-activated Mg2+-ATPase activity more rapidly than soluble kinase phosphorylates and activates soluble myosin I in the absence of membranes. However, the enhanced activity of membrane-bound kinase (which is comparable to the activity of kinase in the presence of phosphatidylserine) is not due to autophosphorylation of the membrane-bound kinase, which is very much slower than for kinase activated by phosphatidylserine vesicles. KW - biochemistry KW - kinases KW - myosins KW - parasites KW - Acanthamoeba castellanii KW - acanthamoebidae KW - protozoa KW - sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805410&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker. AU - Di Marzo Veronese, F. AU - Reitz, M. S. Jr AU - et al. AU - Gupta, G. ( JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1993/// VL - 268 IS - 34 SP - 25894 EP - 25901 SN - 0021-9258 AD - Di Marzo Veronese, F.: Laboratory of Tumor Cell Biology, Building 37, Room 6B23, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005568. Publication Type: Journal Article. Language: English. KW - Conformation KW - envelope protein gp120 KW - epitopes KW - human immunodeficiency viruses KW - Immunology KW - Monoclonal antibodies KW - Neutralization KW - Pathogenesis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenic determinants KW - body conformation KW - gp120 KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. AU - Mills, J. L. AU - Holmes, L. B. AU - Aarons, J. H. AU - Simpson, J. L. AU - Brown, Z. A. AU - Jovanovic-Peterson, L. G. AU - Conley, M. R. AU - Graubard, B. I. AU - Knopp, R. H. AU - Metzger, B. E. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 5 SP - 593 EP - 597 SN - 0098-7484 AD - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892, USA. N1 - Accession Number: 19941402651. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 58-08-2. Subject Subsets: Human Nutrition N2 - Within 21 days of conception 431 women were enrolled in a multicentre study which lasted throughout pregnancy. Mean caffeine consumption during the first trimester was not significantly greater in women who aborted (125.9±123.1) than in women who delivered live infants (111.6±107.0 mg). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval (CI), 0.89 to 1.49). Early foetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group who took most caffeine (>300 mg daily) had a significantly higher proportion of babies with birth weight and head circumference below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (especially smoking) were taken into account. The adjusted ORs were 1.11 (95% CI 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI 0.86 to 1.37) for smaller head circumference. KW - abortion KW - birth weight KW - caffeine KW - fetal death KW - fetal growth KW - intake KW - pregnancy KW - risk KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disorders KW - foetal death KW - foetal growth KW - gestation KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402651&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. AU - Mills, J. L. AU - Holmes, L. B. AU - et al. AU - Aarons, J. H. ( JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 5 SP - 593 EP - 597 AD - Mills, J. L.: Pediatric Epidemiology Section, Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020264. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Public Health N2 - To examine the relationship between caffeine consumption during pregnancy and the occurrence of spontaneous abortion and intrauterine growth retardation, the authors investigated a cohort of 431 women enrolled in a multicentre study in the USA within 21 days of conception. They monitored the women throughout pregnancy to determine (1) caffeine exposure, (2) exposure to other risk factors, (3) fetal growth as assessed by ultrasonography, and (4) pregnancy outcome, measuring spontaneous abortion, intrauterine growth, birth weight, and head circumference.The mean (±SD) first-trimester caffeine consumption was not significantly higher in women who aborted (125.9±123.1 mg) than in women who delivered liveborn infants (111.6±107.0 mg) (P = 34). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval [CI], 0.89 to 1.49). Early fetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group consuming the most caffeine (>300 mg/d) had a significantly higher proportion of babies with birth weights and head circumferences below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (notably smoking) were taken into account. The adjusted ORs were 1.11 (95% CI, 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI, 0.86 to 1.37) for smaller head circumference. [In the mouse (Renwick Med. Sci. Res. 1988 16, 431-2) and also in the rat (data of Collins et al., 1983, Food Chem. Toxicol, 21, 763-7) the detrimental effect of caffeine on total healthy litter mass follows a cube 'law'. In other words, the dose-response curve is non-linear and steep. Thus, if man follows a similar law, one expects the damage to be especially noticable among the heavier consumers of caffeine (≥300 mg/day) and the data are compatible with the expectation. The sample size (24) of this category is pitiably small and is further reduced to 13 (by non-availability of data) for the crucial test. It is therefore not surprising that the highly significant excess of low-birthweight infants (<10th percentile) in this group becomes non-significant after adjustment for confounders.The authors unjustifiably claim "good statistical power" whereas their actual data could be entirely consistent with a marked detrimental effect of what they term "heavy" caffeine use-3 cups of coffee or more daily as an average over the three trimesters of pregnancy.]J.H. Renwick KW - abortion KW - beverages KW - coffee KW - Food KW - Pregnancy KW - women KW - Coffea KW - man KW - Rubiaceae KW - Rubiales KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - caffeine use KW - drinks KW - gestation KW - intrauterine growth KW - spontaneous KW - Human Reproduction and Development (VV060) KW - Food Science and Food Products (Human) (QQ000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020264&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Viral gastroenteritis. AU - Kapikian, A. Z. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 5 SP - 627 EP - 628 SN - 0098-7484 AD - Kapikian, A. Z.: National Institutes of Health, Bldg 7, Room 103, Bethesda, MD 20892, USA. N1 - Accession Number: 19942020769. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A report of a case due to a rotavirus and discussion of other forms of viral gastroenteritis (eg. due to Norwalk virus). KW - Diarrhoea KW - gastroenteritis KW - infections KW - reviews KW - viral diseases KW - Norwalk virus KW - Rotavirus KW - Norovirus KW - Caliciviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Reoviridae KW - dsRNA viruses KW - diarrhea KW - scouring KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942020769&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Probing the meaning of racial/ethnic group comparisons in crack cocaine smoking. AU - Lillie-Blanton, M. AU - Anthony, J. C. AU - Schuster, C. R. AU - Fullilove, M. T.\Fullilove, M. T. JO - Journal of the American Medical Association JF - Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 8 SP - 993 EP - 997, 1034 AD - Lillie-Blanton, M.: Addiction Research Center, National Institute on Drug Abuse, Alcohol, Drug Abuse, and Mental Health Administration, PO Box 5180, Baltimore, MD 21224, USA. N1 - Accession Number: 19932020260. Publication Type: Journal Article. Language: English. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5. Subject Subsets: Public Health N2 - This article addresses an important issue in the epidemiology of drug use, namely "to make a distinction between race as a risk factor and race as a risk marker" as Mindy T. Fullilove puts it in an editorial (p. 1034). The authors reanalysed the data of the widely disseminated and accepted findings of the 1988 National Household Survey of Drug Abuse (NHSDA). This report showed prevalence rates for life-time (ever) use of crack cocaine to be twice as high for African Americans and Hispanic Americans as among white Americans. The analysis did not attempt to account for the underlying macrosocial environmental risk factors or determinants of prevalence, which may underpin the bases of interpreting the data. Macrosocial factors "operate at a societal rather than individual level ... and have their origin in constructs such as what is valued by people as important, the strength of beliefs and the extent to which individuals experience themselves as a part of a larger social organism". Methods and the statistical instruments are described in detail in the text. Suffice it to note that "once survey respondents were grouped into neighbourhood clusters, in effect holding constant shared characteristics, such as drug availability and social conditions, the odds of crack cocaine use did not differ significantly by race/ethnicity." N.H. Rathod KW - cocaine KW - crack KW - Drugs KW - crack cocaine KW - medicines KW - pharmaceuticals KW - racial/ethnic group comparisons KW - users KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020260&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Smoking and lung function in elderly men and women: the Cardiovascular Health Study. AU - Higgins, M. W. AU - Enright, P. L. AU - et al. AU - Kronmal, R. A. ( JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 21 SP - 2741 EP - 2748 SN - 0098-7484 AD - Higgins, M. W.: National Institutes of Health, National Heart, Lung, and Blood Institute, Federal Bldg., Room 2C08, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19942027221. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors investigated relationships between cigarette smoking and pulmonary function in total of 5201 non-institutionalized men and women 65 years of age and older from defined communities in Forsyth County, North Carolina; Pittsburg, Pennsylvania; Sacramento County, California; and Washington County, Maryland. Pulmonary function was measured as means of forced expiratory volume in 1 second (FEV1) and forced vital capacity and prevalence of low FEV1 levels. Prevalence of cigarette smoking was 10-20% and higher in women than men and in blacks than whites. Forced vital capacity and FEV1 levels were related positively to height and white race and negatively to age and waist girth. Age- and height-adjusted FEV1 means were 23% and 18% lower in male and female current smokers, respectively, than in never smokers but not reduced in never smokers currently living with a smoker. Smokers who quit before age 40 years had FEV1 levels similar to never smokers, but FEV1 levels were lower by 7% and 14% in smokers who quit at ages 40-60 years and older than 60 years, respectively. Lung function was related inversely to pack-years of cigarette use. Prevalence rates of impaired lung function were highest in current smokers and lowest in never smokers. Regression coefficients for the smoking variables were smaller in persons without cardiovascular or respiratory conditions than in the total cohort. Cigarette smoking is associated with reduced pulmonary function in elderly men and women. However, smokers who quit, even after age 60 years, have better pulmonary function than continuing smokers. From AS KW - elderly KW - lung function KW - Tobacco smoking KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - aged KW - elderly people KW - older adults KW - senior citizens KW - United States of America KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027221&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Declining serum total cholesterol levels among US adults: the National Health and Nutrition Examination Surveys. AU - Johnson, C. L. AU - Rifkind, B. M. AU - Sempos, C. T. AU - Carroll, M. D. AU - Bachorik, P. S. AU - Briefel, R. R. AU - Gordon, D. J. AU - Burt, V. L. AU - Brown, C. D. AU - Lippel, K. AU - Cleeman, J. I. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 23 SP - 3002 EP - 3008 SN - 0098-7484 AD - Johnson, C. L.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institute of Health, BLdg 31, Room 4A-05, Bethesda MD 20892, USA. N1 - Accession Number: 19941410573. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - National representative cross-sectional surveys with both in-person interview and a medical screening involving the measurement of blood lipids in 6000 and 13 000 adults 20 to 74 years old were examined in 4 separate surveys between 1960 and 1991. The study demonstrated that mean serum total cholesterol levels in US adults within this age range consistently declined over the time period l960 to l991. More than half of the decline occurred between 1976 and l991. This decline occurred across the entire distribution of serum cholesterol levels and in all age-sex groups. High-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol levels have not changed, suggesting that the decline in total cholesterol levels is due to a decline in low-density lipoprotein levels. Thus, public health programs, designed to reduce cholesterol levels, has proved successful. This trend has coincided with a continuing decline in coronary heart disease. The goal of reducing the mean serum cholesterol level of US adults to no more that 200 mg/100 ml (5.17 mmol/litre) appears to be attainable. KW - adults KW - blood KW - blood lipids KW - cardiovascular diseases KW - cholesterol KW - heart diseases KW - nutrition programmes KW - trends KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - feeding programmes KW - feeding programs KW - food programs KW - nutrition programs KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410573&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence of high blood cholesterol among US adults: an update based on guidelines from the second report of the National Cholesterol Education Program Adult Treatment Panel. AU - Sempos, C. T. AU - Cleeman, J. I. AU - Carroll, M. D. AU - Johnson, C. L. AU - Bachorik, P. S. AU - Gordon, D. J. AU - Burt, V. L. AU - Briefel, R. R. AU - Brown, C. D. AU - Lippel, K. AU - Rifkind, B. M. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 23 SP - 3009 EP - 3014 SN - 0098-7484 AD - Sempos, C. T.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 31, Room 4A-05, Bethesda, MD 20892, USA. N1 - Accession Number: 19941410576. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition N2 - From the data collection in the second period of the National Health and Nutrition Examination Survey (NHANES II) (l976 through 1980) to the period in the third survey (NHANES III) (l988 through l991) the proportion of adults with high blood cholesterol levels (≥ 240 mg/100 ml) fell from 26 to 20%, while the proportion with desirable levels (below 200 mg/100 ml) increased from 44 to 49%. Currently, using the Adult Treatment Panel (ATP II) guidelines and NHANES III data, 40% of all adults 20 years or older would require fasting lipid analysis, and 29% of all adults would be candidates for dietary therapy (as compared with 36% using NHANES II data). Based on l990 population data, it is estimated that about 52 million Americans 20 years or older would be candidates for dietary therapy. Assuming that dietary intervention would reduce LDL cholesterol levels by 10%, as many as 7% (12.7 million) of all adult Americans might be candidates for cholesterol-lowering drugs. This estimate reflects about 4 million adults with established coronary heart disease, of whom half are 65 years old or older, and up to 8.7 million adults without established coronary heart disease, of whom up to 3.1 million are 65 years old or older. KW - adults KW - blood pressure KW - nutrition surveys KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - nutritional surveys KW - United States of America KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410576&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of high blood cholesterol in adults (Adult Treatment Panel II). JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 269 IS - 23 SP - 3015 EP - 3023 SN - 0098-7484 AD - National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 31, Room 4A-05, Bethesda, MD 20892, USA. N1 - Accession Number: 19941410574. Publication Type: Journal Article. Corporate Author: Expert Panel on Detection, Evaluaion, and Treatment of High Blood Cholesterol in Adults Language: English. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The second report of by Expert Panel of the National Cholesterol Education Program (NCEP) on detection, evaluation and treatment of high blood cholesterol in adults contains the following updated recommendations for cholesterol management: (1) Increased emphasis on coronary heart disease (CHD) risk as guide to type and intensity of cholesterol-lowering therapy, including identification of patients with CHD and other atherosclerotic diseases, (2) addition of age to the list of major CHD risk facts, (3) recommendation of delaying the use of drug therapy in younger men and premenopausal women who are otherwise at low risk for CHD and (4) enhanced recognition that high-risk postmenopausal women and high-risk elderly patients who are otherwise in good health, are candidates for cholesterol-lowering therapy. Also, (1) More attention to high-density lipoprotein (HDL) as a CHD risk factor, (2) addition of HDL cholesterol to initial cholesterol testing, (3) designation of high HDL cholesterol as a negative CHD risk factor and (4) consideration of HDL cholesterol level in the choice of drug therapy. Finally, increased emphasis on physical activity and weight loss as component of the dietary therapy of high blood pressure. KW - adults KW - blood KW - blood lipids KW - cholesterol KW - diet KW - diet treatment KW - hyperlipaemia KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - diet prescription KW - hyperlipemia KW - United States of America KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410574&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiretroviral therapy for adult HIV-infected patients: recommendations from a State-of-the-Art Conference. AU - Sande, M. A. AU - Carpenter, C. C. J. AU - Cobbs, C. G. AU - Holmes, K. K. AU - Sanford, J. P. AU - Randall, P. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1993/// VL - 270 IS - 21 SP - 2583 EP - 2589 SN - 0098-7484 AD - Sande, M. A.: (P. Randall) Office of Communications, Building 31A, Room 7A50, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005347. Publication Type: Journal Article. Language: English. Registry Number: 30516-87-1. KW - analogues KW - Guidelines KW - HIV infections KW - nucleoside analogues KW - nucleosides KW - Treatment KW - Zidovudine KW - analogs KW - AZT KW - human immunodeficiency virus infections KW - nucleoside analogs KW - recommendations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005347&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of maltase in the utilization of sucrose by Candida albicans. AU - Williamson, P. R. AU - Huber, M. A. AU - Bennett, J. E. JO - Biochemical Journal (London) JF - Biochemical Journal (London) Y1 - 1993/// VL - 291 IS - 3 SP - 765 EP - 771 SN - 0264-6021 AD - Williamson, P. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19931214831. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9001-42-7. Subject Subsets: Medical & Veterinary Mycology N2 - Two isoenzymes of maltase [α-glucosidase] (EC 3.2.1.20) were purified to homogeneity from C. albicans. Isoenzymes I and II were found to have apparent molecular masses of 63 and 66 kDa on SDS/PAGE with isoelectric points of 5.0 and 4.6, respectively. Both isoenzymes resembled each other in similar N-terminal sequence, specificity for the α(1->4) glycosidic linkage and immune cross-reactivity on Western blots using an α-glucosidase II antigen-purified rabbit antibody. α-Glucosidase was induced by growth on sucrose whereas β-fructofuranosidase activity could not be detected under similar conditions. α-Glucosidase I and II were shown to be unglycosylated enzymes by neutral sugar assay, and >90% of α-glucosidase activity was recoverable from spheroplasts. An intracellular localization of the enzyme is suggested. To establish further the mechanism of sucrose assimilation by α-glucosidase, the existence of a sucrose-inducible H+/sucrose syn-transporter was demonstrated by the kinetics of sucrose-induced [14C]sucrose uptake, recovery of intact [14C]sucrose from ground cells by TLC and transport of 0.83 mol of H+/mol of [14C]sucrose. It is concluded that these results are consistent with a mechanism whereby sucrose is transported into C. albicans to be hydrolysed by an intracellular α-glucosidase. KW - alpha-glucosidase KW - enzymes KW - physiology KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - alpha-D-glucosidase KW - fungus KW - Hyphomycetes KW - maltase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214831&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma triglyceride level and mortality from coronary heart disease. AU - Criqui, M. H. AU - Heiss, G. AU - Cohn, R. AU - Cowan, L. D. AU - Suchindran, C. M. AU - Bangdiwala, S. AU - Kritchevsky, S. AU - Jacobs, D. R., Jr. AU - O'Grady, H. K. AU - Davis, C. E. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1993/// VL - 328 IS - 17 SP - 122 EP - 1225 SN - 0028-4793 AD - Criqui, M. H.: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941400521. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The association between plasma triacylglycerol values and the 12-year incidence of death from coronary heart disease was studied in 10 North American populations participating in the Lipid Research Clinics Follow-up Study, while adjusting for the potential confounding effects of other risk factors for cardiovascular disease, including HDL cholesterol concentration. All analyses were sex-specific, and separate analyses were performed in high and low strata of HDL cholesterol, LDL cholesterol, fasting plasma glucose and age. The rates of coronary death in men and women increased with the triacylglycerol concentration. In Cox proportional-hazards models adjusted for age, in which the natural log of the triacylglycerol values were used to give a normal distribution, the relative risk per natural-log unit of triacylglycerol (e.g., a triacylglycerol value of 150 mg/100 ml compared with a value of 55 mg/100 ml) was 1.54 (95% confidence interval (CI) 1.19 to 1.98; P<0.001) in men and 1.88 (95% CI 1.19 to 2.98; P = 0.007) in women. After an adjustment for potential covariates, however, these relative risks were not significant. Analyses based on lipoprotein cholesterol values revealed a positive association between the triacylglycerol value and coronary mortality in the lower stratum of HDL and LDL cholesterol, but not in the higher stratum. Conversely, the HDL cholesterol value was unrelated to coronary mortality in the lower stratum of LDL cholesterol, but was strongly inversely associated with coronary death in the higher stratum of LDL cholesterol. The relative risk of coronary death associated with triacylglycerol concentration was higher at younger ages. The associations between the triacylglycerol value and coronary mortality in the lower HDL cholesterol, LDL cholesterol and age strata were small and were further reduced by an adjustment for fasting plasma glucose. Overall, the plasma triacylglycerol value showed no independent association with coronary mortality. However, in subgroups of subjects with lower HDL and LDL cholesterol values and in younger subjects, defined a priori, an association between the triacylglycerol value and coronary mortality was observed, although this association was small and was not significant after an adjustment for plasma glucose. KW - age KW - blood KW - cholesterol KW - heart diseases KW - lipoproteins KW - mortality KW - sex differences KW - triacylglycerols KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - death rate KW - triglycerides KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400521&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Educational status and active life expectancy among older blacks and whites. AU - Guralnik, J. M. AU - Land, K. C. AU - Blazer, D. AU - Fillenbaum, G. G. AU - Branch, L. G. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1993/// VL - 329 IS - 2 SP - 110 EP - 116 SN - 0028-4793 AD - Guralnik, J. M.: National Institute on Aging, 7201 Wisconsin Avenue, Rm. 3C-309, Bethesda, MD 20892, USA. N1 - Accession Number: 19932023362. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health KW - adults KW - life expectancy KW - Mortality KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - America (North) KW - death rate KW - educational status KW - United States of America KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The risk of childhood cancer after neonatal exposure to vitamin K. AU - Klebanoff, M. A. AU - Read, J. S. AU - Mills, J. L. AU - Shiono, P. H. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1993/// VL - 329 IS - 13 SP - 905 EP - 908 SN - 0028-4793 AD - Klebanoff, M. A.: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Bldg., Room 7B03, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002356. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 12001-79-5. Subject Subsets: Public Health N2 - The authors examined the relation between vitamin K and cancer in a nested case-control study in the USA that used data from the Collaborative Perinatal Project, a multicentre, prospective study of pregnancy, delivery, and childhood. Among 54 795 children born from 1959 through 1966, 48 cases of cancer were diagnosed after the first day of life and before the eighth birthday. Each case child was matched with five randomly selected controls whose last study visit occurred at or after the age when the case child's cancer was diagnosed. Exposure to vitamin K was determined from study forms and medical records. Vitamin K has been administered to 68% of the 44 case children and 71% of the 226 controls for whom data were available (matched odds ratio, 0.84; 95% confidence interval, 0.41 to 1.71). The odds ratio was 0.47 (95% confidence interval, 0.14 to 1.55) for leukaemia and 1.08 (95% confidence interval, 0.45 to 2.61) for other cancers. Sequential adjustment for potential confounding factors did not change the results substantially. The authors found no association between exposure to vitamin K and an increased risk of any childhood cancer or of all childhood cancers combined, although a slightly increased risk could not be ruled out. The benefits of neonatal vitamin K prophylaxis against haemorrhagic disease have been well described. Unless other evidence supporting an association between vitamin K and cancer appears, there is no reason to abandon the routine administration of vitamin K to newborns. KW - children KW - human diseases KW - neoplasms KW - risk factors KW - vitamin K KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002356&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient. AU - Kost, R. G. AU - Hill, E. L. AU - Tigges, M. AU - Straus, S. E. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1993/// VL - 329 IS - 24 SP - 1777 EP - 1782 SN - 0028-4793 AD - Kost, R. G.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952006511. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 59277-89-3. N2 - A case report in a 24-year-old man from USA. KW - aciclovir KW - case reports KW - herpes KW - human diseases KW - male genitalia KW - men KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - acyclovir KW - male genital system KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of HTLV-I in development of non-Hodgkin lymphoma in Jamaica and Trinidad and Tobago. AU - Manns, A. AU - Cleghorn, F. R. AU - et al. AU - Falk, R. T. ( JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1993/// VL - 342 IS - Dec. 11 SP - 1447 EP - 1450 SN - 0140-6736 AD - Manns, A.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd 434, Rockville, MD 20852, USA. N1 - Accession Number: 19942005033. Publication Type: Journal Article. Corporate Author: USA, HTLV Lymphoma Study Group Language: English. KW - Aetiology KW - HTLV infections KW - non-Hodgkin's lymphoma KW - Risk factors KW - Caribbean KW - Jamaica KW - Trinidad and Tobago KW - America KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - Threshold Countries KW - Lesser Antilles KW - causal agents KW - etiology KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Trinidad & Tobago KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005033&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Procreation and HIV. AU - Dublin, S. AU - Blatner, W. A. AU - White, G. C. II AU - Goedert, J. J. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1993/// VL - 342 SP - 1241 EP - 1242 SN - 0140-6736 AD - Dublin, S.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19932004870. Publication Type: Correspondence. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - haemophilia KW - Heterosexual transmission KW - HIV infections KW - Prevention KW - Safer sex KW - AIDS KW - hemophilia KW - human immunodeficiency virus infections KW - Procreation KW - safe sex KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004870&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Disseminated human herpesvirus 6 infection in AIDS. AU - Corbellino, M. AU - Lusso, P. AU - Gallo, R. C. AU - Parravicini, C. AU - Galli, M. AU - Moroni, M. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1993/// VL - 342 SP - 1242 EP - 1242 SN - 0140-6736 AD - Corbellino, M.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932004871. Publication Type: Correspondence. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - disseminated infections KW - Pathogenesis KW - Human herpesvirus 6 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - AIDS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932004871&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of natural killer cells by human herpesvirus 6. AU - Lusso, P. AU - Malnati, M. S. AU - Garzino-Demo, A. AU - Crowley, R. W. AU - Long, E. O. AU - Gallo, R. C. JO - Nature, UK JF - Nature, UK Y1 - 1993/// VL - 362 IS - Apr. 1 SP - 458 EP - 462 AD - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19932020511. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Natural killer (NK) cells are a functionally defined subset of non-T, non-B lymphocytes of bone marrow origin, which induce lysis of selected target cells, including neoplastic and virus-infected cells. The NK cell function provides an important mechanism of primary defence against viruses in vivo, as demonstrated by the occurrence of multiple herpesvirus infections in patients. The authors show that functionally competent CD3- NK clones can be productively infected by human herpesvirus 6 (HHV-6), a T-lymphotropic DNA virus that may play a role in the acquired immunodeficiency syndrome (AIDS) and in the chronic fatigue syndrome, two disorders associated with a defective NK cell activity. The infection is cytopathic and induces de novo expression of CD4 (an antigen not expressed within the NK lineage), thereby predisposing NK cells to infection by human immunodeficiency virus type 1 (HIV-1). These results provide evidence that a herpesvirus can directly target and kill NK cells, a potential strategy to suppress the natural anti-viral immunity of the host. AS/D.J. Morris KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - cellular biology KW - cofactors KW - envelope glycoproteins KW - HIV infections KW - Immunology KW - Natural killer cells KW - receptors KW - human herpesvirus 6 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - AIDS KW - CD4 expression KW - cell biology KW - human immunodeficiency virus infections KW - Immune dysfunction KW - killing KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for the development of obesity. AU - Ravussin, E. AU - Fontvieille, A. M. AU - Swinburn, B. A. AU - Bogardus, C. A2 - Klimeš, I. A2 - Howard, B. V. A2 - Storlien, L. H. A2 - Šeböková, E. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1993/// VL - 683 SP - 141 EP - 150 SN - 0077-8923 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North Sixteenth Street, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19941401018. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - Risk factors for the development of obesity are reviewed, including: components of energy expenditure; risk factors for body weight gain; fat balance vs. energy balance; and implications for treatment. KW - body weight KW - energy balance KW - fats KW - obesity KW - reviews KW - risk KW - treatment KW - weight gain KW - Slovakia KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Dietary Lipids and Insulin Action - Second International Smolenice Insulin Symposium KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401018&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrient and food group intake by tobacco use status: the 1987 National Health Interview Survey. AU - Subar, A. F. AU - Harlan, L. C. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1993/// VL - 686 SP - 310 EP - 322 SN - 0077-8923 AD - Subar, A. F.: Applied Research Branch, National Cancer Institute, National Institutes of Health, Executive Plaza North, Room 313, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941402143. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - Data from the 1987 National Health Interview Survey (USA) investigating dietary differences among never, former and current tobacco users is discussed. KW - diet studies KW - tobacco smoking KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402143&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Carotenoids, cancer, and clinical trials. AU - Ziegler, R. G. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1993/// VL - 691 SP - 110 EP - 119 SN - 0077-8923 AD - Ziegler, R. G.: Nutritional Epidemiology Section, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North 443, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941405487. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition N2 - Clinical trials of cancer epidemiology and carotenoid intake are reviewed. KW - carcinoma KW - carotenoids KW - diet KW - intake KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - tetraterpenoids KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405487&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Laboratory diagnosis of candidiasis. AU - Walsh, T. J. AU - Pizzo, P. A. A2 - Bodey, G. P. T2 - Candidiasis: pathogenesis, diagnosis and treatment. Y1 - 1993/// IS - Ed. 2 CY - New York; USA PB - Raven Press SN - 0881679542 AD - Walsh, T. J.: Infectious Disease Section, Department of Pediatrics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200559. Publication Type: Book chapter. Language: English. Number of References: 134 ref. Subject Subsets: Medical & Veterinary Mycology KW - blood KW - candidosis KW - detection KW - diagnosis KW - fungaemia KW - histopathology KW - human diseases KW - infections KW - polymerase chain reaction KW - reviews KW - serology KW - techniques KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - candidiasis KW - fungemia KW - fungus KW - Hyphomycetes KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200559&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fundamental immunology. A2 - Paul, W. E. T2 - Fundamental immunology. Y1 - 1993/// IS - Ed. 3 CY - New York; USA PB - Raven Press SN - 0781700221 AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804963. Publication Type: Book. Language: English. Subject Subsets: Helminthology; Protozoology; Medical & Veterinary Entomology N2 - This 3rd edition retains the the overall organizational structure of the first edition: one of increasing complexity. It begins with an introductory section dealing with the immune system and a history of immunology. This is followed by 2 sections (which deal with the organization and development of the immune system, and antigens, antibodies and receptors) which deal in detail with key aspects of immunology. The next 4 sections (on lymphocyte activation, proliferation and differentiation, the major histocompatibility complex, regulation of the immune response, and effector mechanisms of immunity) give in-depth discussion of individual topics. The final section covers immunological mechanisms in disease (autoimmunity and autoimmune diseases, transplantation and graft rejection, tumour immunology, immunoparasitology, immunity to viruses, immunity to intracellular bacteria, immunity to extracellular bacteria, vaccines, primary immunodeficiency diseases, immunology of HIV infection, allergy and mechanisms of hypersensitivity). The 40 chapters (each by experts in their fields) provide a wide range of information in this rapidly advancing field. KW - helminths KW - immunology KW - parasites KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - parasitic worms KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Giardia lamblia and giardiasis. AU - Nash, T. E. A2 - Warren, K. S. T2 - Immunology and molecular biology of parasitic infections. Y1 - 1993/// IS - Ed. 3 CY - Oxford; UK PB - Blackwell Scientific Publications Ltd SN - 0865420955 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA. N1 - Accession Number: 19930807461. Publication Type: Book chapter. Language: English. Number of References: 149 ref. Subject Subsets: Protozoology N2 - A short account of the biology of Giardia lamblia [Giardia duodenalis] is followed by discussions of innate resistance, immune responses, humoral responses in humans, cellular immunity in humans, immune responses in G. muris infections, and immunodiagnosis. KW - human diseases KW - immunology KW - parasites KW - reviews KW - Giardia duodenalis KW - Hexamitidae KW - man KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807461&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Leishmaniasis. AU - Sacks, D. L. AU - Louis, J. A. AU - Wirth, D. F. A2 - Warren, K. S. T2 - Immunology and molecular biology of parasitic infections. Y1 - 1993/// IS - Ed. 3 CY - Oxford; UK PB - Blackwell Scientific Publications Ltd SN - 0865420955 AD - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA. N1 - Accession Number: 19930807464. Publication Type: Book chapter. Language: English. Number of References: 267 ref. Subject Subsets: Protozoology N2 - A brief discussion of the disease forms of leishmaniasis (cutaneous, mucocutaneous, visceral) is followed by a review of immunodiagnosis, DNA probe-based diagnosis, encounters of Leishmania parasites with the nonimmune vertebrate host (complement, attachments to macrophages, intramacrophage survival), use of molecular biology to understand pathogenesis; immunologic parameters and immunopathologic aspects of human leishmaniasis, animal models of infection with Leishmania, and cellular parameters associated with immunologic unresponsiveness in visceral L. donovani infection. KW - human diseases KW - immunology KW - parasites KW - reviews KW - Leishmania KW - man KW - protozoa KW - Sarcomastigophora KW - Trypanosomatidae KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807464&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Mechanisms of acquired immunity against parasites. AU - Sher, A. AU - Scott, P. A. A2 - Warren, K. S. T2 - Immunology and molecular biology of parasitic infections. Y1 - 1993/// IS - Ed. 3 CY - Oxford; UK PB - Blackwell Scientific Publications Ltd SN - 0865420955 AD - Sher, A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA. N1 - Accession Number: 19930807450. Publication Type: Book chapter. Language: English. Number of References: 72 ref. Subject Subsets: Helminthology; Protozoology N2 - The different manifestations of acquired immunity against parasitic infections are reviewed and the immunological effector mechanisms currently implicated in both naturally acquired and vaccine-induced resistance are discussed. Immunity induced by previous infection, premunition, concomitant immunity, immunity stimulated by inoculation of attenuated parasites, immunization with native or recombinant antigens or peptide epitopes, molecular basis of immune recognition, antibody-dependent effector mechanisms, cell-mediated immunity, regulation of acquired immunity (by antibodies, cells and cytokines), genetic influences on protective immunity and the role of antigen presentation on the induction of protective immune responses against parasites are considered. KW - helminths KW - human diseases KW - immunity KW - immunology KW - parasites KW - reviews KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930807450&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The historical road to the discovery of Borrelia burgdorferi. AU - Burgdorfer, W. A2 - Weber, K. A2 - Burgdorfer, W. T2 - Aspects of Lyme borreliosis. JO - Aspects of Lyme borreliosis. JF - Aspects of Lyme borreliosis. Y1 - 1993/// SP - 21 EP - 28 CY - Berlin; Germany PB - Springer-Verlag SN - 3540556281\0387556281 AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA. N1 - Accession Number: 19930517483. Publication Type: Miscellaneous. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology KW - history KW - Human diseases KW - Lyme disease KW - research KW - Tickborne diseases KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - lyme borreliosis KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Research (AA500) KW - History and Biography (BB500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517483&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Ultrastructure of Borrelia burgdorferi. AU - Hayes, S. F. AU - Burgdorfer, W. A2 - Weber, K. A2 - Burgdorfer, W. T2 - Aspects of Lyme borreliosis. JO - Aspects of Lyme borreliosis. JF - Aspects of Lyme borreliosis. Y1 - 1993/// SP - 29 EP - 43 CY - Berlin; Germany PB - Springer-Verlag SN - 3540556281\0387556281 AD - Hayes, S. F.: Department of Health and Human Services, Public Helath Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA. N1 - Accession Number: 19930517484. Publication Type: Miscellaneous. Language: English. Number of References: 49 ref. Subject Subsets: Medical & Veterinary Entomology KW - Electron microscopy KW - ultrastructure KW - Borrelia burgdorferi KW - Spirochaetaceae KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517484&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Genome mapping and linkage analysis in Plasmodium falciparum: toward identification of the chloroquine resistance determinant. AU - Wellems, T. E. A2 - Morzaria, S. P. T2 - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992. JO - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992. JF - Genome analysis of protozoan parasites: Proceedings of a Workshop held at ILRAD, Nairobi, Kenya 11-13 November 1992. Y1 - 1993/// SP - 45 EP - 53 CY - Nairobi; Kenya PB - International Laboratory for Research on Animal Diseases (ILRAD) SN - 9290552964 AD - Wellems, T. E.: Genetics and Pharmacology Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801767. Publication Type: Conference paper. Language: English. Number of References: 33 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Protozoology N2 - Chromosome mapping and linkage analysis is reviewed with reference to Plasmodium falciparum and specifically the identification of the chloroquine resistance determinant. KW - antimalarials KW - antiprotozoal agents KW - chloroquine KW - drug resistance KW - gene mapping KW - genome analysis KW - parasites KW - reviews KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801767&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Clinical use of cytokines during fungal infections. AU - Roilides, E. AU - Walsh, T. J. AU - Pizzo, P. A. A2 - Furth, R. van T2 - Hemopoietic growth factors and mononuclear phagocytes. JO - Hemopoietic growth factors and mononuclear phagocytes. JF - Hemopoietic growth factors and mononuclear phagocytes. Y1 - 1993/// SP - 90 EP - 97 CY - Basel; Switzerland PB - S. Karger AG SN - 3805556780 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19931215046. Publication Type: Miscellaneous. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The pathogenesis of specific fungal infections are discussed, and experimental and clinical studies of the role of cytokines in these infections (due to Candida spp., Aspergillus spp., Histoplasma capsulatum, Cryptococcus neoformans and Trichosporon beigelii) in immunocompromised hosts, are also considered. KW - cytokines KW - immunology KW - immunotherapy KW - infections KW - Aspergillus KW - Candida KW - Cryptococcus neoformans KW - Histoplasma capsulatum KW - Man KW - Trichosporon beigelii KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Trichosporon KW - Trichosporonaceae KW - Ajellomyces capsulatus KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931215046&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - In situ kinetics and ascorbic acid requirements. AU - Levine, M. AU - Cantilena, C. C. AU - Dhariwal, K. R. A2 - Simopoulos, A. P. T2 - Nutrition and fitness in health and disease. JO - Nutrition and fitness in health and disease. JF - Nutrition and fitness in health and disease. Y1 - 1993/// SP - 114 EP - 127 CY - Basel; Switzerland PB - S Karger AG SN - 380555706X AD - Levine, M.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941400757. Publication Type: Conference paper. Language: English. Number of References: 81 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - A review. The optimum amount of ascorbic acid (AA) for man remains unknown. Optimum requirements can be determined by learning how biochemical function is regulated by vitamin concentration, and how those concentrations are achieved in man. Biochemical evidence indicates that this approach is feasible. Clinical evidence is needed to learn whether AA concentrations can be achieved which control biochemical function, and to reveal how AA concentrations are regulated by ingestion. For the first time, these clinical studies are possible. In situ kinetics offers a new approach to achieving optimum requirements for vitamin C, and for other vitamins. KW - ascorbic acid KW - metabolism KW - requirements KW - reviews KW - Greece KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Balkans KW - Southern Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - 2nd International Conference on Nutrition and Fitness KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400757&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The search for new pharmaceutical crops: drug discovery and development at the National Cancer Institute. AU - Cragg, G. M. AU - Boyd, M. R. AU - Cardellina, J. H., II AU - Grever, M. R. AU - Schepartz, S. AU - Snader, K. M. AU - Suffness, M. A2 - Janick, J. A2 - Simon, J. E. T2 - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991. JO - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991. JF - New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991. Y1 - 1993/// SP - 161 EP - 167 CY - New York; USA PB - John Wiley and Sons, Inc. SN - 0471593745 AD - Cragg, G. M.: Natural Products Branch, National Cancer Institute, Frederick Cancer R&D Center, Frederick, Maryland 21702, USA. N1 - Accession Number: 19960303212. Publication Type: Conference paper. Language: English. Number of References: 13 ref. Registry Number: 33069-62-4. Subject Subsets: Botanical Pesticides; Horticultural Science N2 - Past and present activities at the United States National Cancer Institute are discussed in 3 sections: Plant acquisition programme; Drug discovery and development (in particular, screening for cytotoxicity and anti-HIV activity); and Large-scale production of taxol (covering early development of taxol, isolated from Taxus brevifolia, current status of taxol development, and alternative sources of taxol). KW - anticancer properties KW - antineoplastic agents KW - antiviral properties KW - cytotoxicity KW - diterpenoid alkaloids KW - drugs KW - medicinal plants KW - paclitaxel KW - pharmacology KW - plant composition KW - production KW - research KW - screening KW - USA KW - Taxus KW - Taxus brevifolia KW - Taxaceae KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Taxus KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - anti-cancer properties KW - anti-viral properties KW - chemical constituents of plants KW - cytotoxic agents KW - drug plants KW - human immunodificiency virus KW - medicinal herbs KW - medicines KW - New crops: exploration, research and commercialization KW - officinal plants KW - pharmaceuticals KW - screening tests KW - studies KW - taxol KW - United States of America KW - Plant Composition (FF040) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960303212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Sporogonic development of malaria parasites in mosquitoes and in vitro. AU - Warburg, A. A2 - Borovsky, D. A2 - Spielman, A. T2 - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993. JO - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993. JF - Host regulated developmental mechanisms in vector arthropods: Proceedings of the Third Symposium, Vero Beach, Florida, February 8-11, 1993. Y1 - 1993/// SP - 234 EP - 239 CY - Vero Beach, Florida; USA PB - University of Florida - IFAS, Florida Medical Entomology Laboratory SN - 0961522445 AD - Warburg, A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B2-37, Bethesda, MD 20892, USA. N1 - Accession Number: 19930517463. Publication Type: Conference paper. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology KW - development KW - Disease vectors KW - in vitro KW - Infections KW - parasites KW - Sporogony KW - Sporozoites KW - Aedes aegypti KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium falciparum KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - Aquatic Biology and Ecology (MM300) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517463&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The role of plants in the drug discovery program of the United States National Cancer Institute. AU - Cragg, G. M. AU - Boyd, M. R. AU - Cardellina, J. H., II AU - Grever, M. R. AU - Schepartz, S. A. AU - Snader, K. M. A2 - Buxton, D. R. A2 - Shibles, R. A2 - Forsberg, R. A. A2 - Blad, B. L. A2 - Asay, K. H. A2 - Paulsen, G. M. A2 - Wilson, R. F. T2 - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992. JO - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992. JF - International crop science I. International Crop Science Congress, Ames, Iowa, USA, 14-22 July 1992. Y1 - 1993/// SP - 465 EP - 472 CY - Madison, WI; USA PB - Crop Science Society of America SN - 0891185380 AD - Cragg, G. M.: Natural Products Branch, Developmental Therapeutics Program, National Cancer Institute, Suite 206, Fairview Center, PO Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19941607939. Publication Type: Conference paper. Language: English. Number of References: 38 ref. Registry Number: 33069-62-4. Subject Subsets: Plant Genetic Resources N2 - A systematic effort to collect and screen plants for pharmaceutical (anti-cancer) properties was initiated in 1960 by the National Cancer Institute (NCI) in collaboration with the USDA. By 1982, 35 000 collections had been made in over 60 countries in the temperate regions. Although this research was discontinued because few novel active agents were being isolated, the development of a new screen led to the programme's resumption in 1986. Since 1988, following the development of a high-flux anti-HIV screen, the programme has been extended to anti-AIDS testing of plant materials. This paper examines the research with reference to those plant materials which have advanced to clinical trials, under the following headings: (1) status of plant-derived anti-cancer agents; (2) NCI plant collection programme from 1986 to the present; (3) natural product drug discovery and development; (4) drug development and supply issues; (5) large scale production of taxol; (6) large scale production of biomass: NCI policies; (7) plant-derived agents: recent NCI discoveries; and (8) international collaboration and compensation (NCI letter of intent and programme expansion to tropical countries). KW - acquired immune deficiency syndrome KW - antineoplastic agents KW - drugs KW - genetic resources KW - human immunodeficiency viruses KW - international agreements KW - international cooperation KW - medicinal properties KW - neoplasms KW - paclitaxel KW - pharmaceutical products KW - plant genetic resources KW - screening KW - temperate zones KW - USA KW - plants KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cancers KW - cytotoxic agents KW - gene resources KW - human immunodeficiency virus KW - International Crop Science I KW - medicines KW - pharmaceuticals KW - screening tests KW - taxol KW - United States of America KW - Biological Resources (Plant) (PP720) KW - Plant Composition (FF040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941607939&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Dietary antigens and regulation of the mucosal immune response. AU - Strober, W. A2 - Cunningham-Rundles, S. T2 - Nutrient modulation of the immune response. JO - Nutrient modulation of the immune response. JF - Nutrient modulation of the immune response. Y1 - 1993/// SP - 533 EP - 540 CY - New York; USA PB - Marcel Dekker, Inc. SN - 0824784480 AD - Strober, W.: National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19931466586. Publication Type: Miscellaneous. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - Dietary antigens and regulation of the mucosal immune response are reviewed. KW - antigens KW - food allergies KW - foods KW - immune response KW - mucosa KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - food hypersensitivity KW - immunity reactions KW - immunogens KW - immunological reactions KW - mucous membrane KW - Host Resistance and Immunity (HH600) KW - Food Science and Food Products (Human) (QQ000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931466586&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Growth factors and malignant transformation. AU - Aaronson, S. A. AU - Miki, T. AU - Meyers, K. AU - Chan, A. A2 - Zappia, V. A2 - Salvatore, M. A2 - Ragione, F. D. T2 - Advances in nutrition and cancer. Y1 - 1993/// CY - New York; USA PB - Plenum Publishing Corporation SN - 0306446707 AD - Aaronson, S. A.: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941410232. Publication Type: Book chapter. Language: English. Number of References: 85 ref. Subject Subsets: Human Nutrition N2 - This review is introduced by referring to the convergence of research aimed at identifying the functions of retroviral oncogenes with investigations of normal mitogenic signalling by growth factors. The subject is covered under the headings: Growth factor requirements for cell proliferation; Receptor tyrosine kinases and their effectors; Oncogene subversion of specific signalling pathways; Implication of other mitogenic signalling systems in malignancy; Expression cloning of growth regulatory genes; Expression cloning of a transforming gene from a human sarcoma cDNA library; Transforming properties of Gα12; and Overexpression of wild-type Gα12 is sufficient for transformation. KW - cell growth KW - growth factors KW - neoplasms KW - oncogenes KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cell elongation KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The invasion of erythrocytes by malarial merozoites. AU - Ward, G. E. AU - Chitnis, C. E. AU - Miller, L. H. A2 - Russell, D. G. JO - Bailliere's Clinical Infectious Diseases JF - Bailliere's Clinical Infectious Diseases Y1 - 1994/// VL - 1 IS - 2 SP - 155 EP - 190 AD - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805277. Publication Type: Journal Article. Language: English. Number of References: 179 ref. Subject Subsets: Protozoology N2 - This review summarizes what is currently known about the mechanisms underlying the invasion of erythrocytes by Plasmodium merozoites under the headings: experimental systems for studying invasion (receptor-ligand studies, other aspects of invasion); apical organelles (rhoptries, micronemes, dense granules); merozoite plasma membrane; proteases; steps in invasion (receptor-ligand interactions, signal transduction, parasitophorous vacuole formation, parasite entry). Future prospects are discussed. KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - human diseases KW - parasites KW - reviews KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - blood red cells KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805277&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A conformational epitope on the dimer of the fusion protein of respiratory syncytial virus detected in natural infections. AU - Subbarao, E. K. AU - Beeler, J. A. AU - Waner, J. L. JO - Clinical and Diagnostic Virology JF - Clinical and Diagnostic Virology Y1 - 1994/// VL - 1 IS - 5/6 SP - 313 EP - 323 SN - 0928-0197 AD - Subbarao, E. K.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942026925. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A murine monoclonal antibody (MAb), 2D8, was used in immunofluorescence reactions to detect respiratory syncytial virus (RSV) antigen in clinical specimens. Nasopharyngeal epithelial cells from 63 of 66 children with RSV infections reacted with this MAb. The MAb was further characterized and was demonstrated to recognize a conformational epitope on the dimer of the fusion protein of RSV. No reaction was detected with the MAb, 2D8, on Western blots of antigen prepared from RSV-infected HEp-2 cells under reducing conditions. Under non-reducing conditions, 2D8 reacted with a 145-170 K protein; this reactivity was lost when the antigen preparation was heated to 100 °C, 2D8 reacted with purified F glycoprotein of RSV Long in an ELISA, neutralized infectivity of RSV by >50% at a dilution of 1:500, and was able to inhibit cell-to-cell fusion of RSV-infected cells. In a competitive ELISA, the epitope detected by 2D8 was localized to antigenic site A. The conformational epitope detected by 2D8 required protein dimerization and glycosylation for full reactivity. This report extends previous characterizations of the F protein in its native state in that the MAb defines a conformational epitope on the fusion protein dimer that is expressed in natural infections and elicits antibody that can neutralize virus infectivity and inhibit cell-to-cell fusion. In addition to its application as a diagnostic reagent, this MAb can be of use in testing preparations of RSV or purified F protein in which the purification or extraction processes could have destroyed conformational epitopes. AS KW - diagnosis KW - infections KW - monoclonal antibodies KW - North America KW - Oklahoma KW - USA KW - human respiratory syncytial virus KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - viruses KW - America KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Southern Plains States of USA KW - West South Central States of USA KW - Southern States of USA KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026925&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of Japanese encephalitis virus antigens in the CSF using monoclonal antibodies. AU - Desai, A. AU - Chandramuki, A. AU - Gourie-Devi, M. AU - Ravi, V. JO - Clinical and Diagnostic Virology JF - Clinical and Diagnostic Virology Y1 - 1994/// VL - 2 IS - 3 SP - 191 EP - 199 SN - 0928-0197 AD - Desai, A.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. N1 - Accession Number: 19952005554. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 308067-57-4. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology N2 - Samples obtained from 115 patients with a clinical diagnosis of Japanese encephalitis (JE) were used to evaluate 2 monoclonal antibody-based detection methods. The results were compared to the detection of IgM antibodies in the CSF. The diagnostic tests used were a reverse passive haemagglutination test for the detection of soluble JEV antigens, an immunofluorescent assay for the detection of cell-associated antigen and an IgM capture ELISA for the detection of virus specific IgM antibodies in the CSF. Laboratory confirmation of JE was possible in 92/115 patients. Virus-specific IgM was detected in 75/92 and JEV antigen was detected in 52/92 patients. Soluble antigen was detected in 37/52, cell-associated antigen in 30/52. There was no significant difference in the sensitivity of the 2 antigen detection systems used. Diagnosis by antigen detection could be done less frequently than by demonstration of virus-specific IgM antibodies in the spinal fluid. However, antigen detection proved useful during the first week of illness when IgM antibodies were not detected in the CSF. KW - arboviruses KW - cerebrospinal fluid KW - diagnosis KW - ELISA KW - fluorescence KW - haemagglutination tests KW - human diseases KW - IgM KW - immunodiagnosis KW - immunoglobulins KW - Japanese encephalitis KW - monoclonal antibodies KW - nervous system diseases KW - Asia KW - India KW - Japanese encephalitis virus KW - man KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - arthropod-borne viruses KW - enzyme linked immunosorbent assay KW - gamma-globulins KW - hemagglutination tests KW - immune globulins KW - neuropathy KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rotavirus vaccine development for the prevention of severe diarrhoea in infants and young children. AU - Hoshino, Y. AU - Kapikian, A. Z. JO - Trends in Microbiology JF - Trends in Microbiology Y1 - 1994/// VL - 2 IS - 7 SP - 242 EP - 249 SN - 0966-842X AD - Hoshino, Y.: Epidemiology Section, Laboratory of the Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008531. Publication Type: Journal Article. Language: English. Number of References: 73 ref. KW - children KW - diarrhoea KW - human diseases KW - immunization KW - infants KW - vaccine development KW - man KW - rotavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - diarrhea KW - immune sensitization KW - scouring KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evolving patterns of nosocomial and community-acquired deep mycoses: analogies to other infections and implications for practitioners. AU - Walsh, T. J. JO - Infectious Diseases in Clinical Practice JF - Infectious Diseases in Clinical Practice Y1 - 1994/// VL - 3 IS - Suppl. 2 SP - S103 EP - S112 SN - 1056-9103 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941202160. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 107 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The changing patterns in the epidemiology, diagnosis and treatment of nosocomial and community-acquired deep mycoses are reviewed and several analogies are drawn between nosocomial fungal infections and nosocomial bacterial infections, as these 2 types of infection relate to changes in the hosts and antimicrobial pressures. Epidemiological implications for vaccine development, the role of the clinical mycology laboratory as a critical interface between bedside diagnosis and therapeutic intervention, and development of antifungal compounds are also discussed. KW - antifungal agents KW - diagnosis KW - drug therapy KW - epidemiology KW - human diseases KW - mycoses KW - nosocomial infections KW - therapy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - evolving etiologies of invasive mycoses KW - fungistats KW - hospital infections KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941202160&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Second International Conference on Cryptococcus and Cryptococcosis, Milan (Italy), September 19-23, 1993. Closing address. AU - Bennett, J. E. JO - Journal de Mycologie Médicale JF - Journal de Mycologie Médicale Y1 - 1994/// VL - 4 IS - 2 SP - 125 EP - 127 SN - 1156-5233 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19941201398. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Recent research advances in Cryptococcus neoformans infections that were presented at this conference are summarized. Cell mediated and humoral immunity mechanisms, molecular biology and gene cloning techniques, and the epidemiology of cryptococcosis are discussed. KW - epidemiology KW - genetics KW - immunology KW - research KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - 2nd International conference on Cryptococcus and cryptococcosis KW - fungus KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201398&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment and developmental therapeutics of Mycobacterium tuberculosis infections. AU - Georgiev, V. S. JO - International Journal of Antimicrobial Agents JF - International Journal of Antimicrobial Agents Y1 - 1994/// VL - 4 IS - 3 SP - 157 EP - 173 SN - 0924-8579 AD - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, NIH, Solar Building, Room 4C-04, Bethesda, MD 20892, USA. N1 - Accession Number: 19952000738. Publication Type: Journal Article. Language: English. Number of References: 169 refs. Subject Subsets: Public Health N2 - A review article which discusses the incidence of tuberculosis and both current and novel methods of treatment. KW - drug therapy KW - human diseases KW - new drugs KW - reviews KW - tuberculosis KW - man KW - Mycobacterium tuberculosis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - chemotherapy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000738&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of human immunodeficiency virus type 1 RNAs in vitro. AU - Dropulic´, B. AU - Jeang, K. T. JO - Antisense Research and Development JF - Antisense Research and Development Y1 - 1994/// VL - 4 IS - 3 SP - 217 EP - 221 SN - 1050-5261 AD - Dropulic´, B.: (K.T. Jeang) Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050970. Publication Type: Journal Article. Language: English. Registry Number: 63231-63-0. KW - antiviral agents KW - human immunodeficiency viruses KW - molecular biology KW - RNA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - ribonucleic acid KW - ribozymes KW - secondary structure KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050970&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol consumption during pregnancy and infant birth weight. AU - Faden, V. B. AU - Graubard, B. I. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1994/// VL - 4 IS - 4 SP - 279 EP - 284 SN - 1047-2797 AD - Faden, V. B.: Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, 5600 Fishers Lane, Room 14C26, Rockville, MD 20857, USA. N1 - Accession Number: 19951406765. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - Data for the study were gathered as part of the National Longitudinal Survey of Youth, a multistage, stratified, clustered probability sample of housing units drawn to be representative of the population of young persons in the USA. Of the 4409 births remaining in the sample after multiple births and subjects with incomplete information were eliminated, alcohol drinking was reported by 1506 mothers during pregnancy and no drinking by 2903. Consumption of alcohol less than once a month was reported for 738, about once a month for 362, 3 to 4 times a month for 208, once or twice weekly for 1248, 3 to 4 times weekly for 32 and every day or nearly every day for 18 women during pregnancy. Multiple linear regression and logistic regression were used to adjust the relation between drinking and birth weight for relevant covariates. There was a non-significant trend in the direction of greater numbers of babies of low birth born to mothers who consumed alcoholic beverages more frequently during pregnancy. There was an interaction between drinking alcoholic beverages and smoking in which the negative effects on birth weight of smoking were less for those women who drank more heavily (P=0.046). KW - alcoholic beverages KW - birth weight KW - intake KW - mothers KW - neonates KW - pregnancy KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - gestation KW - newborn infants KW - United States of America KW - Human Reproduction and Development (VV060) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406765&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Radon exposure in residences and lung cancer among women: combined analysis of three studies. AU - Lubin, J. H. AU - Liang, Z. H. AU - et al. AU - Hrubec, Z. ( JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1994/// VL - 5 IS - 2 SP - 114 EP - 128 SN - 0957-5243 AD - Lubin, J. H.: Biostatistics Branch, National Cancer Institute, Executive Plaza North, Room 403, 6130 Executive Blvd, Rockville, MD 20852, USA. N1 - Accession Number: 19942050319. Publication Type: Journal Article. Language: English. Registry Number: 10043-92-2. Subject Subsets: Public Health; Tropical Diseases N2 - Lung cancer risk in relation to indoor radon was examined in three case-control studies in Stockholm (Sweden), New Jersey (United States), and Shenyang (People's Republic of China). Year-long measurements of radon gas were made in current and past homes of 966 women who developed lung cancer and of 1158 control women, included in the combined analysis. Nearly 14% of the participants were estimated to have a time-weighted, mean, radon concentration in their homes of more than 4 pCi/1 (150 Bq/m³) during the period from five to 35 years prior to the date of lung cancer diagnosis (or comparable date for controls). There was a tendency for risk to increase with increasing levels of radon in NJ and Stockholm, but the trends for individual studies and overall were not statistically significant. The estimates of the excess relative risk for indoor exposure per pCi/l were 0.18 (95% [CI] = 0.04-0.70) in NJ, 0.06 (CI = 0.05-0.34) in Stockholm, and -0.02 (CI = -χ-0.03) for Shenyang; these estimates did not differ significantly from each other. The overall excess RR per pCi/l was 0.00 (CI = 0.05-0.07); the confidence limits were sufficiently broad, however, that the overall estimate was still compatible with extrapolations of risks from miners. Cigarette smoking was the predominant cause of lung cancer with the RR significantly elevated in all studies. Within smoking categories, the trend in risk with increasing mean radon concentration was inconsistent. Analyses of data from several studies are complicated by the possibility that there may exist important differences in study bases which might affect results, and which may be controlled only partially through adjustment procedures. Future efforts to combine various residential studies will need to be attentive to the intrinsic limitations of studies to detect low levels of risk as well as the unique uncertainties associated with estimating, accurately, cumulative exposure to indoor radon. AS KW - comparisons KW - lung cancer KW - lungs KW - neoplasms KW - radon KW - risk factors KW - Toxicology KW - women KW - Asia KW - China KW - Europe KW - New Jersey KW - North America KW - Sweden KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - European Union Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancer sites KW - cancers KW - People's Republic of China KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050319&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupation, physical activity, and risk of prostate cancer in Shanghai, People's Republic of China. AU - Hsing, A. W. AU - McLaughlin, J. K. AU - Zheng, W. AU - Gao, Y. T. AU - Blot, W. J. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1994/// VL - 5 IS - 2 SP - 136 EP - 140 SN - 0957-5243 AD - Hsing, A. W.: Division of Cancer Etiology, Epidemiology and Biostatistics Program, National Cancer Institute, EPN 415, 6130 Executive Blvd., Bethesda, MD 20892, USA. N1 - Accession Number: 19942050316. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Based on occupational data for all (n = 264) prostate cancer cases diagnosed during 1980-84 in urban Shanghai and on employment information from the 1982 census, standardized incidence ratios (SIR) were calculated for occupational groups classified by job type and physical activity level. White-collar workers (professionals, government officials, clerical workers, salespersons) had an elevated incidence of prostate cancer, although the excesses were not significant. In addition, when jobs were classified by time spent sitting or energy expenditure, men employed in occupations with low physical activity levels tended to have moderately elevated risks of prostate cancer. Findings from this study in an area with one of the world's lowest incidence rates of prostate cancer add to the accumulating evidence that jobs with a low level of physical activity are associated with an increased prostate-cancer risk. AS KW - neoplasms KW - prostate KW - prostate cancer KW - risk factors KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - People's Republic of China KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A case-control interview study of breast cancer among Japanese A-bomb survivors. I. Main effects. AU - Land, C. E. AU - Hayakawa, N. AU - Machado, S. G. AU - Yamada, Y. AU - Pike, M. C. AU - Akiba, S. AU - Tokunaga, M. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1994/// VL - 5 IS - 2 SP - 157 EP - 165 SN - 0957-5243 AD - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute 6130 Rockville Pike, EPN 408, Rockville, MD 20852, USA. N1 - Accession Number: 19952000633. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Women with breast cancer (cases = 196) and without the disease (controls = 566), selected from the Life Span Study sample of A-bomb survivors and non-exposed residents of Hiroshima and Nagasaki, Japan, and matched on age at the time of the bombings, city, and estimated radiation dose, were interviewed about reproductive and medical history. A primary purpose of the study was to identify strong breast cancer risk factors that could be investigated further for possible interactions with radiation dose. As expected, age at first full-term pregnancy was strongly and positively related to risk. Inverse associations were observed with number of births and total, cumulative period of breast feeding, even after adjustment for age at first full-term pregnancy. Histories of treatment for dysmenorrhoea and for uterine or ovarian surgery were associated positively and significantly with risk at ages 55 or older, a finding that requires additional study. Other factors related to risk at older ages were the Quetelet index (weight [kg]/height [cm]²) at age 50, history of thyroid disease, and hypertension. Neither age at menarche nor age at menopause was associated significantly with risk. Subjects appeared to be poorly informed about history of breast cancer or other cancer in themselves or in their close relatives; this finding suggests that innovative strategies may be required when studying familial cancer patterns in Japanese populations. AS/Danielle Horton KW - breast KW - breast cancer KW - eyes KW - human diseases KW - neoplasms KW - radiation KW - risk factors KW - Asia KW - Japan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000633&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A case-control interview study of breast cancer among Japanese A-bomb survivors. II. Interactions with radiation dose. AU - Land, C. E. AU - Hayakawa, N. AU - Machado, S. G. AU - Yamada, Y. AU - Pike, M. C. AU - Akiba, S. AU - Tokunaga, M. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1994/// VL - 5 IS - 2 SP - 167 EP - 176 SN - 0957-5243 AD - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute, 6130 Rockville Pike, EPN 408, Rockville, MD 20852, USA. N1 - Accession Number: 19952000634. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Three breast cancer risk factors were evaluated in terms of their interactions with radiation dose in a case-control interview study of Japanese A-bomb survivors. Cases and controls were matched on age at the time of the bombings and radiation dose, and dose-related risk was estimated from cohort rather than case-control data. Each factor-age at first full-term pregnancy, number of deliveries, and cumulative lactation period summed over births-confirmed reasonably well to a multiplicative interaction model with radiation dose (the additive interactive model, in which the absolute excess risk associated with a factor is assumed to be independent of radiation dose, was rejected). An important implication of the finding is that early age at first full-term pregnancy, multiple births, and lengthy cumulative lactation are all protective against radiation-related, as well as baseline, breast cancer. Analyses by age at exposure to radiation suggest that, among women exposed to radiation in childhood or adolescence, a first full-term pregnancy at an early age following exposure may be protective against radiation-related risk. AS/Danielle Horton KW - breast KW - breast cancer KW - human diseases KW - neoplasms KW - radiation KW - risk factors KW - Asia KW - Japan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000634&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differences in reported food frequency by season of questionnaire administration: the 1987 National Health Interview Survey. AU - Subar, A. F. AU - Frey, C. M. AU - Harlan, L. C. AU - Kahle, L. JO - Epidemiology JF - Epidemiology Y1 - 1994/// VL - 5 IS - 2 SP - 226 EP - 233 SN - 1044-3983 AD - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD, USA. N1 - Accession Number: 19941409357. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - Seasonal reporting in a 59-item food frequency questionnaire (FFQ) administered throughout 1 year using data from the 1987 National Health Interview Survey in the USA (n=20 143 adults) was assessed. Few meaningful differences were found in the proportion of individuals reporting rarely or never consuming a food by season of questionnaire administration. Seasonal reporting bias is evident in FFQs, however, and appears to be due to reporting most recent consumption. Using gender-specific median servings/week, an analysis using logistic regression showed that the estimated proportion of individuals reporting food intake at greater than the yearly median differed between any 2 seasons by at least 5% of the population for 22 foods. Gender specific quintiles of selected nutrients/food groups for the whole year and each season were compared; these showed that quintile assignment never varied by more than 1 adjacent quintile. The most frequent shift in quintile assignment, involving as many as 18.5% of women in the summer, occurred for citrus fruits. The intake biases are small and do not greatly affect population estimates if the FFQ is administered in all seasons, but they may somewhat affect classification of individuals into quantiles for some foods/nutrients. KW - adults KW - diet studies KW - diet study techniques KW - questionnaires KW - seasonal variation KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - seasonal changes KW - seasonal fluctuations KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Erythropoietin for zidovudine-associated anemia in children with HIV infection. AU - Mueller, B. U. AU - Jacobsen, F. AU - Jarosinski, P. AU - Lewis, L. L. AU - Pizzo, P. A. JO - Pediatric AIDS and HIV Infection JF - Pediatric AIDS and HIV Infection Y1 - 1994/// VL - 5 IS - 3 SP - 169 EP - 173 SN - 1045-5418 AD - Mueller, B. U.: Pediatric Branch, National Cancer Institute, Bethesda, Maryland. N1 - Accession Number: 19942007234. Publication Type: Journal Article. Language: English. Registry Number: 11096-26-7, 30516-87-1. KW - Adverse effects KW - Anaemia KW - Children KW - Erythropoietin KW - HIV infections KW - Transfusion KW - Treatment KW - Zidovudine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - anemia KW - AZT KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007234&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiretroviral therapy for infection due to human immunodeficiency virus in children. AU - Pizzo, P. A. AU - Wilfert, C. JO - Pediatric AIDS and HIV Infection JF - Pediatric AIDS and HIV Infection Y1 - 1994/// VL - 5 IS - 5 SP - 273 EP - 295 SN - 1045-5418 AD - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952007930. Publication Type: Journal Article. Language: English. Number of References: 178 ref. KW - acquired immune deficiency syndrome KW - antiviral agents KW - children KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007930&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokines and HIV infection. AU - Shearer, G. M. AU - Clerici, M. AU - Lucey, D. R. JO - Seminars in Virology JF - Seminars in Virology Y1 - 1994/// VL - 5 IS - 6 SP - 449 EP - 455 SN - 1044-5773 AD - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002213. Publication Type: Journal Article. Language: English. Number of References: 63 ref. KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - reviews KW - viral diseases KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene therapy for human immunodeficiency virus infection: genetic antiviral strategies and targets for intervention. AU - Dropulic´, B. AU - Jeang, K. T. JO - Human Gene Therapy JF - Human Gene Therapy Y1 - 1994/// VL - 5 IS - 8 SP - 927 EP - 939 SN - 1043-0342 AD - Dropulic´, B.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004061. Publication Type: Journal Article. Language: English. Number of References: 118 ref. Registry Number: 9007-49-2, 63231-63-0. KW - antiviral agents KW - DNA KW - gene therapy KW - human immunodeficiency viruses KW - RNA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004061&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tracking HIV during disease progression. AU - Pantaleo, G. AU - Fauci, A. S. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1994/// VL - 6 IS - 4 SP - 600 EP - 604 SN - 0952-7915 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Building 10, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007148. Publication Type: Journal Article. Language: English. Number of References: 46 ref. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - disease course KW - HIV infections KW - Pathology KW - AIDS KW - disease progression KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficacy trials of AIDS vaccines: how science can inform ethics. AU - Fast, P. E. AU - Mathieson, B. J. AU - Schultz, A. M. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1994/// VL - 6 IS - 5 SP - 691 EP - 697 SN - 0952-7915 AD - Fast, P. E.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050727. Publication Type: Journal Article. Language: English. Number of References: 70 ref. KW - acquired immune deficiency syndrome KW - HIV infections KW - immune response KW - immunology KW - safety KW - vaccines KW - AIDS KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050727&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Improvements in the lab diagnosis of PCP. AU - Cartwright, C. P. AU - Gill, V. J. JO - AIDS Clinical Care JF - AIDS Clinical Care Y1 - 1994/// VL - 6 IS - 10 SP - 79 EP - 79, 81, 88 SN - 1043-1543 AD - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19952005202. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - bronchoalveolar lavage KW - clinical aspects KW - diagnosis KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - opportunistic infections KW - Pneumocystis carinii pneumonia KW - polymerase chain reaction KW - prophylaxis KW - sputum KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005202&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The human filariases: new understandings, new therapeutic strategies. AU - Ottesen, E. A. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1994/// VL - 7 IS - 5 SP - 550 EP - 558 SN - 0951-7375 AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803973. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - This review covers: the parasite and its diagnosis; pathogenesis and clinical understanding (lymphatic filariasis, onchocerciasis); treatment and control (lymphatic filariasis, onchocerciasis, loiasis, post-treatment reactions). KW - diagnosis KW - drug therapy KW - filariasis KW - helminths KW - human diseases KW - parasites KW - reviews KW - Brugia malayi KW - Loa loa KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - Wuchereria KW - African eyeworm KW - chemotherapy KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803973&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunoglobulin class and subclass antibodies to HIV proteins in maternal serum: association with perinatal transmission. AU - Mann, D. L. AU - Hamlin-Green, G. AU - Willoughby, A. AU - Landesman, S. H. AU - Goedert, J. J. JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1994/// VL - 7 IS - 6 SP - 617 EP - 622 SN - 0894-9255 AD - Mann, D. L.: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Room 21-78, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19942006722. Publication Type: Journal Article. Language: English. KW - Antibodies KW - HIV infections KW - human immunodeficiency virus infections KW - Isotype KW - Perinatal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006722&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The drugs 2′,3′-dideoxyinosine (ddI) and 2′,3′-dideoxycytidine (ddC) are safe alternatives in people with AIDS with zidovudine-induced myopathy. AU - Jay, C. AU - Ropka, M. AU - Dalakas, M. C. T2 - Journal of Acquired Immune Deficiency Syndromes JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1994/// VL - 7 IS - 6 SP - 630 EP - 631 SN - 0894-9255 AD - Jay, C.: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19942006727. Publication Type: Correspondence. Language: English. Registry Number: 69655-05-6, 7841-89-2, 30516-87-1. KW - Adverse effects KW - Didanosine KW - Dideoxycytidine KW - HIV infections KW - muscular diseases KW - Treatment KW - Zidovudine KW - adverse reactions KW - AZT KW - dideoxyinosine KW - human immunodeficiency virus infections KW - myopathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006727&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterosexual transmission of human immunodeficiency virus type 1 from transfusion recipients to their sex partners. AU - O'Brien, T. R. AU - Busch, M. P. AU - et al. AU - Donegan, E. ( JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1994/// VL - 7 IS - 7 SP - 705 EP - 710 SN - 0894-9255 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Executive Plaza North Building, Room 434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19942006868. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Heterosexual transmission KW - HIV infections KW - AIDS KW - human immunodeficiency virus infections KW - Transfusion recipients KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006868&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cigarette smoking, premature rupture of membranes, and vertical transmission of HIV-1 among women with low CD4+ levels. AU - Burns, D. N. AU - Landesman, S. AU - et al. AU - Muenz, L. R. ( JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1994/// VL - 7 IS - 7 SP - 718 EP - 726 SN - 0894-9255 AD - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Suite 4B11, Rockville, MD 20852, USA. N1 - Accession Number: 19942006888. Publication Type: Journal Article. Language: English. KW - HIV infections KW - Maternal transmission KW - Pregnancy KW - Risk factors KW - Smoking KW - CD4+ lymphocyte counts KW - gestation KW - human immunodeficiency virus infections KW - mother to child transmission KW - Premature rupture of membranes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006888&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Improved detection of HTLV-II antibody using a whole viral lysate-based EIA. AU - Kline, R. L. AU - Vlahov, D. AU - Quinn, T. C. T2 - Journal of Acquired Immune Deficiency Syndromes JO - Journal of Acquired Immune Deficiency Syndromes JF - Journal of Acquired Immune Deficiency Syndromes Y1 - 1994/// VL - 7 IS - 12 SP - 1291 EP - 1292 SN - 0894-9255 AD - Kline, R. L.: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19952005341. Publication Type: Correspondence. Language: English. Number of References: 9 ref. KW - ELISA KW - HTLV-I infections KW - HTLV-II infections KW - laboratory tests KW - serology KW - enzyme linked immunosorbent assay KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005341&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current status of prophylaxis for opportunistic infections in HIV-infected patients. AU - Decker, C. F. AU - Masur, H. JO - AIDS JF - AIDS Y1 - 1994/// VL - 8 IS - 1 SP - 11 EP - 20 SN - 0269-9370 AD - Decker, C. F.: (H. Masur) Critical Care Medicine Department, Clinical Center, Building 10 7D43, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005960. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - HIV infections KW - Opportunistic infections KW - Prophylaxis KW - Treatment KW - AIDS KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005960&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The use of the flarephotometry in the detection of cytomegalic virus retinitis in AIDS patients. AU - Nussenblatt, R. B. AU - De Smet, M. AU - et al. AU - Podgor, M. ( T2 - AIDS JO - AIDS JF - AIDS Y1 - 1994/// VL - 8 IS - 1 SP - 135 EP - 136 SN - 0269-9370 AD - Nussenblatt, R. B.: National Eye Institute, National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005982. Publication Type: Correspondence. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Cytomegalovirus retinitis KW - Diagnosis KW - AIDS KW - Flare photometry KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005982&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The differential cytotoxicity of cardenolides from Thevetia ahouia. AU - Decosterd, L. AU - Gustafson, K. R. AU - Cardellina, J. H., II AU - Cragg, G. M. AU - Boyd, M. R. JO - Phytotherapy Research JF - Phytotherapy Research Y1 - 1994/// VL - 8 IS - 2 SP - 74 EP - 77 SN - 0951-418X AD - Decosterd, L.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950304468. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Horticultural Science N2 - Bioassay-guided fractionation of the cytotoxic organic extracts of the wood of T. ahouia (collected from Honduras) led to the isolation of 3 cardenolide glycosides. These agents exhibited a distinctive pattern of differential cytotoxicity in the National Cancer Institute's human disease-oriented 60-cell line tumour screening panel. KW - cardenolides KW - cell lines KW - cytotoxic compounds KW - cytotoxicity KW - plant composition KW - plant extracts KW - wood KW - Honduras KW - Apocynaceae KW - man KW - Thevetia KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Apocynaceae KW - CACM KW - Central America KW - America KW - Developing Countries KW - Latin America KW - chemical constituents of plants KW - Thevetia ahouia KW - Plant Composition (FF040) KW - Wood Properties, Damage and Preservation (KK510) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950304468&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Risk of HIV infection and AIDS in women and girls with coagulation disorders. AU - Goedert, I. J. AU - Garvey, L. AU - et al. AU - Hilgartner, M. W. ( T2 - AIDS JO - AIDS JF - AIDS Y1 - 1994/// VL - 8 IS - 4 SP - 564 EP - 565 SN - 0269-9370 AD - Goedert, I. J.: AIDS and Cancer Section, Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006471. Publication Type: Correspondence. Language: English. Registry Number: 113189-02-9. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - children KW - Coagulation KW - Factor VIII KW - Girls KW - haemophilia KW - HIV infections KW - Transfusion KW - Transmission KW - Women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - hemophilia KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006471&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AU - Clerici, M. AU - Clark, E. A. AU - Polacino, P. AU - Axberg, I. AU - Kuller, L. R. AU - Casey, N. I. AU - Morton, W. R. AU - Shearer, G. M. AU - Benveniste, R. E. JO - AIDS JF - AIDS Y1 - 1994/// VL - 8 IS - 10 SP - 1391 EP - 1395 SN - 0269-9370 AD - Clerici, M.: Correspondence address: R.E. Benveniste, National Cancer Institute, B560, Frederick, MD 21702, USA. N1 - Accession Number: 19952001384. Publication Type: Journal Article. Language: English. KW - animal models KW - cell mediated immunity KW - human diseases KW - immune response KW - immunization KW - infections KW - mucosa KW - T lymphocytes KW - Macaca KW - simian immunodeficiency virus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cellular immunity KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - mucous membrane KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001384&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overcoming barriers to conducting research. AU - Ford, D. B. AU - Schiller, M. R. JO - Topics in Clinical Nutrition JF - Topics in Clinical Nutrition Y1 - 1994/// VL - 9 IS - 3 SP - 44 EP - 50 SN - 0883-5691 AD - Ford, D. B.: Clinical Nutrition Services, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19951412905. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition N2 - Integrating research and dietetic practice enhances professional roles of the dietitian. This integration is facilitated by strong organizational support and development of a dietetic-based research programme. Research is further strengthened by dietitians' ability to formulate clearly focused research questions and obtain resources, such as mentors and funding, to bring projects to completion. A case example is provided showing how dietitians were able to make significant advances in this area. KW - dietitians KW - funding KW - nutrition research KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412905&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogenetic study of ten new HTLV-I strains from the Americas. AU - Gessain, A. AU - Koralnik, I. J. AU - et al. AU - Fullen, J. ( AU - Franchini, G. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 1 SP - 103 EP - 106 SN - 0889-2229 AD - Gessain, A.: (G. Franchini) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, NIH, 9000 Rockville Pike, Rockville, MD 20892, USA. N1 - Accession Number: 19942006657. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2. KW - DNA KW - DNA sequencing KW - Molecular biology KW - Phylogeny KW - Deltaretrovirus KW - HUMAN T-CELL LYMPHOTROPIC VIRUS KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - deoxyribonucleic acid KW - HTLV-BLV group KW - nucleotide sequence analysis KW - nucleotide sequencing KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006657&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathogenicity, virulence and Entamoeba histolytica. AU - Clark, C. G. AU - Diamond, L. S. JO - Parasitology Today JF - Parasitology Today Y1 - 1994/// VL - 10 IS - 2 SP - 46 EP - 47 AD - Clark, C. G.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940805628. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - An attempt is made to resolve problems regarding the terms 'pathogenicity' and 'virulence' with respect to Entamoeba histolytica. It is concluded that E. histolytica is a pathogen of variable virulence capable of producing invasive disease and E. dispar appears to be an avirulent pathogen incapable of invading tissue. As far as is known E. coli and E. hartmanni are truly non-pathogenic. KW - human diseases KW - parasites KW - pathogenicity KW - terminology KW - virulence KW - Endamoebidae KW - Entamoeba KW - Entamoeba dispar KW - Entamoeba histolytica KW - protozoa KW - Sarcomastigophora KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Endamoebidae KW - Entamoeba KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805628&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro susceptibility of Macaca nemestrina to human herpesvirus 6: a potential animal model of coinfection with primate immunodeficiency viruses. AU - Lusso, P. AU - Secchiero, P. AU - Crowley, R. W. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 2 SP - 181 EP - 187 SN - 0889-2229 AD - Lusso, P.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006682. Publication Type: Journal Article. Language: English. KW - Animal models KW - Pathogenesis KW - Herpesviridae KW - Macaca KW - SIMIAN IMMUNODEFICIENCY VIRUS KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Partial envelope sequences from some of the earliest isolates of HIV-1. AU - Reitz, M. S. Jr AU - Popovic, M. AU - Saxinger, W. C. AU - Hall, L. AU - Read-Connole, E. AU - Markham, P. AU - Gallo, R. C. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 5 SP - 621 EP - 623 SN - 0889-2229 AD - Reitz, M. S. Jr: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050559. Publication Type: Journal Article. Language: English. KW - DNA sequencing KW - env gene KW - genomes KW - human immunodeficiency viruses KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - nucleotide sequence analysis KW - nucleotide sequencing KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050559&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A universally applicable diagnostic approach to filarial and other infections. AU - Nutman, T. B. AU - Zimmerman, P. A. AU - Kubofcik, J. AU - Kostyu, D. D. JO - Parasitology Today JF - Parasitology Today Y1 - 1994/// VL - 10 IS - 6 SP - 239 EP - 243 AD - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19940805159. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Helminthology; Agricultural Biotechnology N2 - This article discusses how the detection of parasite-specific PCR products using an ELISA-based assay can be used to distinguish between past and current infection and to assess efficacy of drug therapy (previously impossible using antibody-based assays, due to extensive cross-reactivity among filarial and other antigens). The filarial parasites considered are: Onchocerca volvulus, Brugia malayi, Loa loa and Wuchereria bancrofti. KW - biotechnology KW - diagnosis KW - DNA probes KW - ELISA KW - filariasis KW - helminths KW - immunodiagnosis KW - parasites KW - polymerase chain reaction KW - Brugia malayi KW - Loa loa KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - Wuchereria KW - African eyeworm KW - enzyme linked immunosorbent assay KW - nematodes KW - parasitic worms KW - PCR KW - Secernentea KW - serological diagnosis KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805159&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells. AU - Kalebic, T. AU - Schein, P. S. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 6 SP - 727 EP - 733 SN - 0889-2229 AD - Kalebic, T.: Laboratory of Molecular Genetics, Pediatric Branch, Building 10 Room 13C215, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051160. Publication Type: Journal Article. Language: English. KW - antiviral agents KW - enzyme inhibitors KW - human immunodeficiency viruses KW - reverse transcriptase inhibitors KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - organic thiophosphate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051160&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A C2 symmetry-based HIV protease inhibitor, A77003, irreversibly inhibits infectivity of HIV-1 in vitro. AU - Kageyama, S. AU - Hoekzema, D. T. AU - Murakawa, Y. AU - Kojima, E. AU - Shirasaka, T. AU - Kempf, D. J. AU - Norbeck, D. W. AU - Erickson, J. AU - Mitsuya, H. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 6 SP - 735 EP - 743 SN - 0889-2229 AD - Kageyama, S.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051161. Publication Type: Journal Article. Language: English. KW - antiviral agents KW - Gag protein KW - human immunodeficiency viruses KW - proteinase inhibitors KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - processing granulocyte monocyte colony-stimulating factor KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051161&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activation of HIV type 1 long terminal repeat by ultraviolet light is serum and strain specific. AU - Carrier, F. AU - McCary, J. M. AU - Bae, I. AU - Yarosh, D. B. AU - Fornace, A. J. Jr JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 7 SP - 767 EP - 773 SN - 0889-2229 AD - Carrier, F.: Laboratory of Molecular Pharmacology, DTP, DCT, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952000324. Publication Type: Journal Article. Language: English. KW - genomes KW - human immunodeficiency viruses KW - molecular biology KW - Tat protein KW - ultraviolet radiation KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - activation KW - human immunodeficiency virus KW - long terminal repeat KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000324&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanism of enzyme inhibition mediated by anti-reverse transcriptase antibodies from HIV type 1-infected individuals. AU - Devico, A. L. AU - Rahman, R. AU - Sarngadharan, M. G. AU - Di Marzo Veronese, F. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 8 SP - 953 EP - 960 SN - 0889-2229 AD - Devico, A. L.: Building 37, Room 6A17, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001302. Publication Type: Journal Article. Language: English. KW - antibodies KW - antiviral agents KW - enzyme inhibitors KW - human immunodeficiency viruses KW - molecular biology KW - reverse transcriptase inhibitors KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001302&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tenth anniversary perspectives on AIDS: phylogenesis and genetic complexity of the nonhuman primary retroviridae. AU - Franchini, G. AU - Reitz, M. S. Jr JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 9 SP - 1047 EP - 1060 SN - 0889-2229 AD - Franchini, G.: Labour of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002647. Publication Type: Journal Article. Language: English. Number of References: 222 ref. KW - evolution KW - molecular biology KW - natural history KW - phylogeny KW - man KW - retroviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RNA Reverse Transcribing Viruses KW - viruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002647&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Binding of glycoprotein 120 and peptides from the HIV-1 envelope by autoantibodies in mice with experimentally induced systemic lupus erythematosus and in patients with the disease. AU - Bermas, B. L. AU - Petri, M. AU - Berzofsky, J. A. AU - Waisman, A. AU - Shearer, G. M. AU - Mozes, E. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 9 SP - 1071 EP - 1077 SN - 0889-2229 AD - Bermas, B. L.: Experimental Immunology Branch, National Cancer Institute, NIH, Building 10, Room 4B-17, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002674. Publication Type: Journal Article. Language: English. Number of References: 37 ref. KW - animal models KW - autoantibodies KW - autoimmunity KW - envelope protein gp120 KW - human diseases KW - human immunodeficiency viruses KW - systemic lupus erythematosus KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gp120 KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002674&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Perinatal transmission of HIV type 1: associations with maternal anti-HIV serological reactivity. AU - Goedert, J. J. AU - Dublin, S. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 9 SP - 1125 EP - 1134 SN - 0889-2229 AD - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19952002683. Publication Type: Journal Article. Language: English. Number of References: 56 ref. KW - antibodies KW - envelope proteins KW - epitopes KW - HIV infections KW - human diseases KW - maternal transmission KW - risk factors KW - antigenic determinants KW - human immunodeficiency virus infections KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002683&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Viral variability and serum antibody response in a laboratory worker infected with HIV type 1 (HTLV type IIIB). AU - Reitz, M. S. Jr AU - Hall, L. AU - Robert-Guroff, M. AU - Lautenberger, J. AU - Hahn, B. M. AU - Shaw, G. M. AU - Kong, L. I. AU - Weiss, S. H. AU - Waters, D. AU - Gallo, R. C. AU - Blattner, W. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 9 SP - 1143 EP - 1155 SN - 0889-2229 AD - Reitz, M. S. Jr: Laboratory of Tumor Cell Biology, National Cancer Institute, Building 37, Room 6A09, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002687. Publication Type: Journal Article. Language: English. Number of References: 45 ref. KW - Env gene KW - human immunodeficiency viruses KW - molecular biology KW - nucleotide sequences KW - occupational transmission KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - DNA sequences KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002687&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor α and interleukin 6 induction of virus. AU - Weissman, D. AU - Poli, G. AU - Fauci, A. S. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 10 SP - 1199 EP - 1206 SN - 0889-2229 AD - Weissman, D.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, Room 6A02, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002065. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 308079-78-9. KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - interleukins KW - macrophages KW - tumour necrosis factor KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002065&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanisms of HIV\SIV mucosal transmission. AU - Milman, G. AU - Sharma O. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 10 SP - 1305 EP - 1312 SN - 0889-2229 AD - Milman, G.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7620, USA. N1 - Accession Number: 19962002076. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 9007-49-2. KW - DNA KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mucosa KW - transmission KW - man KW - simian immunodeficiency virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - mucous membrane KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002076&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction. AU - Neumann, M. AU - Harrison, J. AU - Saltarelli, M. AU - Hadziyannis, E. AU - Erfle, V. AU - Felber, B. K. AU - Pavlakis, G. N. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 11 SP - 1531 EP - 1542 SN - 0889-2229 AD - Neumann, M.: National Cancer Institute, FCRDC, ABL-Basic Research Program, P.O. Box B/Building 539, Room 121 Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962000896. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - gene splicing KW - Human diseases KW - human immunodeficiency viruses KW - molecular biology KW - polymerase chain reaction KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000896&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Subgroup G HIV type 1 isolates from Nigeria. AU - Abimiki, A. G. AU - Stern, T. L. AU - Zwandor, A. AU - Markham, P. D. AU - Calef, C. AU - Kyari, S. AU - Saxinger W. C. AU - Gallo, R. C. AU - Robert-Guroff, M. AU - Reitz, M. S. JO - Aids Research and Human Retroviruses JF - Aids Research and Human Retroviruses Y1 - 1994/// VL - 10 IS - 11 SP - 1581 EP - 1583 SN - 0889-2229 AD - Abimiki, A. G.: Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, National Institutes of Health, 900 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19962000902. Publication Type: Journal Article. Language: English. Number of References: 8 ref. KW - genetic variation KW - HIV infections KW - Human diseases KW - human immunodeficiency viruses KW - molecular biology KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic variability KW - genotypic variability KW - genotypic variation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - subtypes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25H expressed in yeast and purified using nickel-NTA agarose. AU - Kaslow, D. C. AU - Shiloach, J. JO - Bio/Technology JF - Bio/Technology Y1 - 1994/// VL - 12 IS - 5 SP - 494 EP - 498 SN - 0733-222X AD - Kaslow, D. C.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008350. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology N2 - The authors have constructed a second generation malaria transmission-blocking vaccine candidate based on Pfs25, the predominate surface protein of Plasmodium falciparum zygotes, to overcome potential production problems with the original construct. Four modifications were made: (1) addition of the last cysteine residue of the fourth epidermal growth factor like-domain of Pfs25; (2) mutagenesis of asparagine-linked glycosylation sites with glutamine rather than alanine; (3) addition of a six histidine tag at the carboxyterminus for highly efficient purification of recombinant protein on nickel-NTA agarose; and (4) fermentation that combines continuous glucose fed-batch methodology with pH-controlled glucose addition and a terminal ethanol feed. The resulting product, TBV25H (Transmission-Blocking Vaccine based on Pfs25 with a Histidine tag), appears to be a more potent antigen and immunogen than the original construct, and the fermentation and post-fermentation processing methodology easily lend themselves to technology transfer to the ultimate users, newly industrialized countries. KW - candidate vaccines KW - human diseases KW - malaria KW - parasites KW - production KW - recombinant vaccines KW - surface antigens KW - transmission blocking immunity KW - vaccines KW - zygotes KW - man KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium KW - Pfs25 KW - transmission blocking vaccines KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008350&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site. AU - Sugimoto, Y. AU - Aksentijevich, I. AU - Gottesman, M. M. AU - Pastan, I. JO - Bio/Technology JF - Bio/Technology Y1 - 1994/// VL - 12 IS - 7 SP - 694 EP - 698 SN - 0733-222X AD - Sugimoto, Y.: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940106314. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 82410-32-0, 9002-06-6, 57-22-7. Subject Subsets: Agricultural Biotechnology N2 - A new retroviral vector system (pSXLC/pHa) was constructed which utilizes a putative ribosome internal entry site (IRES) from encephalomyocarditis virus, downstream of a multicloning site, to coexpress drug-selectable markers with a non-selectable cDNA in a eukaryote expression vector. The positive drug-selectable marker MDR1 (encoding the plasma membrane P-glycoprotein) and the herpes simplex virus thymidine kinase positive-negative marker (which can act both as a selectable marker in thymidine kinase-deficient cells and as a suicide gene in vivo and vitro) were cloned in the pSXLC/pHa system and, under translational control of IRES, expressed in transfected cultured mammalian cells. The inserts of the 2 pSXLC plasmids were designed for easy transfer to the pHA retroviral vector, which has a strong promoter from Harvey murine sarcoma virus. The retroviral vector carrying IRES-MDR1 conferred resistance to vincristine and adriamycin. The IRES-thymidine kinase vector conferred resistance to HAT medium in thymidine kinase-deficient cells, and the transfectants showed hypersensitivity to ganciclovir. This system is potentially useful in gene therapy strategies. KW - animal viruses KW - antineoplastic agents KW - biotechnology KW - cell lines KW - drug resistance KW - ganciclovir KW - gene expression KW - gene therapy KW - gene transfer KW - marker genes KW - plasmids KW - retroviral vectors KW - thymidine kinase KW - vectors KW - vincristine KW - animals KW - viruses KW - eukaryotes KW - cloning KW - cytotoxic agents KW - selectable markers KW - viruses of animals KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Animal Tissue and Cell Culture (LL700) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940106314&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adaptive control with feedback of suramin using intermittent infusions. AU - Figg, W. D. AU - Stevens, J. A. AU - Cooper, M. R. JO - Journal of Clinical Oncology JF - Journal of Clinical Oncology Y1 - 1994/// VL - 12 IS - 7 SP - 1523 EP - 1524 SN - 0732-183X AD - Figg, W. D.: National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19940806619. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 145-63-1. Subject Subsets: Protozoology KW - antiprotozoal agents KW - parasites KW - pharmacokinetics KW - suramin KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940806619&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunogenicity of recombinant influenza virus haemagglutinin carrying peptides from the envelope protein of human immunodeficiency virus type 1. AU - Kalyan, N. K. AU - Lee, S. G. AU - et al. AU - Wilhelm, J. ( JO - Vaccine JF - Vaccine Y1 - 1994/// VL - 12 IS - 8 SP - 753 EP - 760 SN - 0264-410X AD - Kalyan, N. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006317. Publication Type: Journal Article. Language: English. KW - chimaeras KW - haemagglutinins KW - immune response KW - Immunization KW - influenza viruses KW - Animals KW - Human immunodeficiency virus 1 KW - eukaryotes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Orthomyxoviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - chimeras KW - hemagglutinins KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - Influenzavirus KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Crossover of placebo patients to intravenous immunoglobulin confirms efficacy for prophylaxis of bacterial infections and reduction of hospitalizations in human immunodeficiency virus-infected children. AU - Mofenson, L. M. AU - Moye, J. Jr AU - et al. AU - Korelitz, J. ( JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1994/// VL - 13 IS - 6 SP - 477 EP - 484 SN - 0891-3668 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA. N1 - Accession Number: 19942007062. Publication Type: Journal Article. Language: English. Registry Number: 308067-57-4, 723-46-6, 738-70-5. KW - Bacterial diseases KW - Children KW - clinical trials KW - drug combinations KW - HIV infections KW - immunoglobulins KW - intravenous injection KW - sulfamethoxazole KW - Treatment KW - trimethoprim KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - gamma-globulins KW - human immunodeficiency virus infections KW - immune globulins KW - sulfamethoxazole trimethoprim KW - sulphamethoxazole KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007062&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A blueprint for care, treatment, and prevention of HIV/AIDS in children. AU - Wilfert, C. M. AU - Pizzo, P. A. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1994/// VL - 13 IS - 10 SP - 920 EP - 923 SN - 0891-3668 AD - Wilfert, C. M.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002321. Publication Type: Journal Article. Language: English. Number of References: 13 ref. KW - children KW - community care KW - HIV infections KW - human diseases KW - infants KW - management KW - prevention KW - treatment KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002321&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells. AU - Benkirane, M. AU - Jeang, K. T. AU - Devaux, C. JO - EMBO Journal JF - EMBO Journal Y1 - 1994/// VL - 13 IS - 23 SP - 5559 EP - 5569 SN - 0261-4189 AD - Benkirane, M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004495. Publication Type: Journal Article. Language: English. Number of References: 62 ref. KW - cd4 antigens KW - cells KW - cytoplasm KW - HIV infections KW - immunology KW - infection KW - T lymphocytes KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - human immunodeficiency virus infections KW - surface receptor KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004495&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1994/// VL - 14 IS - 7 SP - 4912 EP - 4919 SN - 0270-7306 AD - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201775. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The molecular basis of capsule synthesis in C. neoformans was studied using a capsule-deficient phenotype of a mutant strain which was complemented by transformation. A plasmid rescued from the resulting Cap+ transformant complemented a cap59 mutation which was mapped previously by classical recombination analysis. Gene deletion by homologous integration resulted in an acapsular phenotype, indicating the identification of the CAP59 gene. The CAP59 gene was assigned to chromosome I by Southern blot analysis of contour-clamped homogeneous electric field gel electrophoresis-resolved chromosomes of C. neoformans var. neoformans. Sequence comparison of genomic and cDNA clones indicated the presence of 6 introns. CAP59 encoded a 1.9 kb transcript and a deduced protein of 458 amino acids. Analysis of the nucleotide sequence revealed little similarity to existing sequences in the data bank. When the capsule-deficient phenotype was complemented, the originally avirulent C. neoformans strain became virulent in mice and the acapsular strain created by gene deletion of CAP59 lost its virulence. It is concluded that these results indicate the molecular basis for capsule-related virulence and that the CAP59 gene is required for capsule formation. KW - complementation KW - experimental infections KW - genetics KW - infections KW - mutants KW - pathogenicity KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - capsule KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201775&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunoglobulin idiotype antigen vaccines for the treatment of lymphomas. AU - Kwak, L. W. JO - Clinical Immunology Newsletter JF - Clinical Immunology Newsletter Y1 - 1994/// VL - 14 IS - 9 SP - 121 EP - 124 SN - 0197-1859 AD - Kwak, L. W.: Biological Response Modifiers Program, National Cancer Institute, Frederick, Maryland, USA. N1 - Accession Number: 19962004023. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 308067-57-4. N2 - The author reviews the use of idiotypic determinants of the surface immunoglobulin of a B cell lymphoma as a tumour-antigen for vaccine development. KW - antigens KW - immunization KW - immunoglobulins KW - lymphoma KW - neoplasms KW - reviews KW - vaccine development KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - cancers KW - gamma-globulins KW - immune globulins KW - immune sensitization KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004023&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis-B markers in sera of Egyptian hepatoma patients. AU - El-Aaser, A. A. AU - Zakhary, N. I. AU - Sharawi, S. M. AU - El-Demerdash, S. AU - Hamza, M. R. AU - Kamel, R. AU - Michael, M. S. JO - Qatar University Science Journal JF - Qatar University Science Journal Y1 - 1994/// VL - 14 IS - SPEC/ISSUE SP - 21 EP - 25 AD - El-Aaser, A. A.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 19982000900. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - To investigate the possible role of hepatitis B virus (HBV) infection in the aetiology of hepatoma among Egyptians, 52 hepatoma patients (aged 38-72 years) from Egypt were studied. The 3 hepatitis B markers, hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb) and hepatitis B core antibody (HBcAb), were estimated in the patients' sera and compared with healthy controls. Results revealed a striking correlation between clinical or subclinical history of HBV infection or even carrier rate, and hepatoma, since 94.2% of the hepatoma patients were positive for one or more of the hepatitis markers studied. The higher prevalence of HBV infection was observed among HCC patients (97%) than among other types of hepatoma patients (66%; P=0.03). HBsAb and HBcAb were positive among 80.8% (P<0.01) and 84.6% (P<0.01) of hepatoma patients; respectively, whereas they were completely absent in sera of controls. However, HBsAg was positive among 13.5% only of the hepatoma patients, revealing no significant changes when compared with controls (P=0.133). No significant correlation was observed between HBsAb positive patients and those who were positive for HBcAb (P=0.35). KW - aetiology KW - antibodies KW - antigens KW - carcinoma KW - clinical aspects KW - disease markers KW - hepatitis KW - hepatitis B KW - hepatoma KW - histopathology KW - human diseases KW - infection KW - neoplasms KW - patients KW - viral diseases KW - Egypt KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - antigenicity KW - cancers KW - causal agents KW - clinical picture KW - etiology KW - immunogens KW - Misr KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000900&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats. AU - Davis, C. D. AU - Schut, H. A. J. AU - Snyderwine, E. G. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1994/// VL - 15 IS - 4 SP - 641 EP - 645 SN - 0143-3334 AD - Davis, C. D.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951413002. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition N2 - The heterocyclic amines 2-amino-3-methylimidazo(4,5-f)quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) are carcinogens that form DNA adducts. The 32P-postlabelling method was used to measure the levels of IQ and PhIP adducts in hepatic nuclear and mitochondrial DNA of Fischer-344 rats given a single dose (100 mg/kg, p.o.) or 10 doses of either carcinogen. After a single dose of IQ, adduct levels were >2-fold higher in hepatic nuclear than in mitochondrial DNA; however, after repeated IQ exposure, the levels of adducts in nuclear and mitochondrial DNA were not significantly different. In contrast, after a single dose of PhIP, there were no significant differences in adduct levels in nuclear and mitochondrial DNA; however, after multiple doses of PhIP, adduct levels were significantly higher in mitochondrial DNA than in nuclear DNA. The percentages of individual IQ or PhIP adducts were different between nuclear DNA and mitochondrial DNA, particularly after 10 doses. With IQ, the C8-guanine adduct accounted for 72% of the total IQ adduct levels in nuclear DNA but only 40% of total adduct levels in mitochondrial DNA. After 10 doses of PhIP, the C8-guanine adduct accounted for 48% and 15% of total adduct levels in nuclear DNA and mitochondrial DNA, respectively. In addition, the percentage of an uncharacterized PhIP adduct was 14% in nuclear DNA but <1% in mitochondrial DNA. The percentages of individual adducts were about the same 3, 24, 120 and 240 h after a single dose of either compound, though total IQ and PhIP adduct levels appeared to decline over time in both organelles. KW - carcinogenesis KW - DNA KW - heterocyclic nitrogen compounds KW - liver KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413002&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet. AU - Devereux, T. R. AU - White, C. M. AU - Sills, R. C. AU - Bucher, J. R. AU - Maronpot, R. R. AU - Anderson, M. W. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1994/// VL - 15 IS - 5 SP - 1083 EP - 1087 SN - 0143-3334 AD - Devereux, T. R.: Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19951412036. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition KW - adenoma KW - antidepressants KW - benzodiazepines KW - carcinoma KW - drugs KW - intake KW - liver KW - neoplasms KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - medicines KW - pharmaceuticals KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412036&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice. AU - Chen, L. C. AU - Sly, L. AU - Luca, L. M. de JO - Carcinogenesis JF - Carcinogenesis Y1 - 1994/// VL - 15 IS - 10 SP - 2383 EP - 2386 SN - 0143-3334 AD - Chen, L. C.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951411159. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - High dietary retinoic acid (RA; 30 µg/g diet) inhibits carcinoma formation in a 2-stage skin carcinogenesis protocol, using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiator and 12-O-tetradecanoyl phorbol-13-acetate (TPA) as the tumour-promoter in female SENCAR mice. The study examined whether switching the diets from high to control levels of RA and vice versa would influence carcinoma formation. Mice at 3 weeks of age were initiated with DMBA (20 µg) once, followed by 20 weekly applications of TPA (2 µg). At 3 weeks of age mice were weaned onto a diet containing RA 3 (control) or 30 (high) µg/g diet. Half of the mice from either group were switched to the other diet at 20 weeks of age, when papilloma formation was at its peak. These 4 groups were designated RA 3 µg, RA 30 µg, RA 3/30 µg and RA 30/3 µg groups. As previously found, papilloma formation (including incidence and yield) was not significantly affected by dietary treatment. However, high dietary RA inhibited carcinoma formation; specifically cumulative carcinoma incidence (18.5-23.1 versus 50%) and yield (0.19-0.23 versus 0.68) were significantly lower in the high dietary RA treatment groups than the RA 3 µg control group, as was the carcinoma conversion efficiency (2.1-3.8 versus 9.4%). The beneficial effect on carcinoma formation was still evident when excess RA was given late during the carcinogenesis process (i.e. the RA 3/30 µg group). Moreover, a residual effect of excess RA was also seen after the dietary RA was switched to the control level at 20 weeks of age, when papilloma yield was highest (i.e. the RA 30/3 µg group). It is therefore concluded that the chemopreventive effect of high dietary RA on skin carcinogenesis induced by a 2-stage carcinogenesis protocol with DMBA and TPA resides mainly at the step of conversion from benign papillomas to malignant carcinomas. KW - carcinogenesis KW - intake KW - papilloma KW - retinoic acid KW - skin KW - vitamins KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dermis KW - papillomas KW - tretinoin KW - vitamin A acid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411159&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Techniques and diagnostic applications of in vitro nucleic-acid amplification. AU - Cartwright, C. P. JO - Clinical Microbiology Newsletter JF - Clinical Microbiology Newsletter Y1 - 1994/// VL - 16 IS - 5 SP - 33 EP - 37 SN - 0196-4399 AD - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942026379. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health KW - amplification KW - diagnosis KW - Infectious diseases KW - nucleic acids KW - reviews KW - communicable diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026379&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical studies on the effect of garlic on liver and intestine of schistosomal mice. AU - Zakhary, N. I. JO - Egyptian Journal of Bilharziasis JF - Egyptian Journal of Bilharziasis Y1 - 1994/// VL - 16 IS - 1/2 SP - 107 EP - 127 AD - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 19960804999. Publication Type: Journal Article. Language: English. Language of Summary: Arabic. Number of References: 44 ref. Registry Number: 9001-78-9, 57-88-5, 9007-49-2, 9005-79-2. Subject Subsets: Botanical Pesticides; Horticultural Science; Helminthology N2 - The protective effect of garlic (Allium sativum) against schistosome infection in mice was investigated. Five groups of 20 mice were treated as follows: uninfected untreated controls; uninfected mice fed on diet containing 20% garlic for 3 weeks; mice infected with 50 cercariae of Schistosoma mansoni and fed on standard diet; S. mansoni-infected mice fed with diet containing 20% garlic for 3 weeks, beginning 1 week before infection; and S. mansoni-infected mice fed with diet containing 20% garlic for 3 weeks, beginning 7 weeks after infection. Growth rate was measured weekly and liver and intestinal homogenates were analysed from 10 mice in each group sacrificed 10 weeks after the start of the experiment. Infected mice showed retarded growth rate and reduced levels of cholesterol, glycogen and enzyme activity in their livers although alkaline phosphatase activity and protein and DNA contents were significantly increased. Enzyme activity was also reduced in the intestine and the DNA content was increased. Infected mice maintained on diet with 20% garlic from 1 week prior to infection showed no significant changes in these parameters, which were similar to those in uninfected untreated controls. There was little difference between these parameters in infected mice fed standard diet and infected mice fed 20% garlic from 7 weeks postinfection, suggesting that garlic is protective against the effects of cercarial infection but not against adult worms. Uninfected mice fed garlic showed no changes when compared with uninfected controls, showing that garlic has no harmful effects on the parameters studied. KW - alkaline phosphatase KW - anthelmintics KW - cercariae KW - cholesterol KW - DNA KW - drug therapy KW - enzyme activity KW - experimental infections KW - extracts KW - garlic KW - glycogen KW - growth KW - helminths KW - intestines KW - laboratory animals KW - liver KW - medicinal plants KW - parasites KW - plant extracts KW - proteins KW - Allium sativum KW - mice KW - Schistosoma mansoni KW - Allium KW - Alliaceae KW - Liliaceae KW - Liliales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - alkaline phosphomonoesterase KW - chemotherapy KW - deoxyribonucleic acid KW - drug plants KW - medicinal herbs KW - officinal plants KW - parasitic worms KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biological Resources (Plant) (PP720) KW - Plant Science (General) (FF000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804999&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Separation of taxol and related compounds by micellar electrokinetic chromatography. AU - Chan, K. C. AU - Muschik, G. M. AU - Issaq, H. J. AU - Snader, K. M. JO - HRC, Journal of High Resolution Chromatography JF - HRC, Journal of High Resolution Chromatography Y1 - 1994/// VL - 17 IS - 1 SP - 51 EP - 52 SN - 0935-6304 AD - Chan, K. C.: National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA. N1 - Accession Number: 19950308100. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Taxol, isolated from the bark and needles of Taxus brevifolia, exhibits antineoplastic and antileukaemic properties. Micellar electrokinetic chromatography was used to separate taxol, cephalomannine and baccatin III, and their deacetylated derivatives, in <15 min, using ng amounts of sample and a few µlitres of solvent per run. KW - analytical methods KW - chromatography KW - diterpenoid alkaloids KW - diterpenoids KW - extraction KW - medicinal plants KW - medicinal properties KW - plant composition KW - Taxaceae KW - Taxus brevifolia KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Taxus KW - Taxaceae KW - analytical techniques KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950308100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The sagittal waist diameter and mortality in men: the Baltimore Longitudinal Study on Aging. AU - Seidell, J. C. AU - Andres, R. AU - Sorkin, J. D. AU - Muller, D. C. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1994/// VL - 18 IS - 1 SP - 61 EP - 67 SN - 0307-0565 AD - Seidell, J. C.: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. N1 - Accession Number: 19941406075. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - The relation between abdominal sagittal diameter (waist depth) and subsequent mortality was evaluated in 981 men (51.2±16.6 years old) from the Baltimore Longitudinal Study on Aging (a prospective study at the National Institute on Aging in Baltimore, USA). The main outcome measures were total and cause-specific mortality occurring during 17 529 person-years. Men were divided by age (<55 years old or >55 years old) at the start of follow-up. All-cause and coronary heart disease mortality rates (adjusted for age, height and body mass index) increased with increasing sagittal diameter in the younger group but not in the older group. No significant relation was observed between the sagittal diameter and cancer mortality. Body mass index, skinfolds and waist/hip ratio were not significantly related to any of the end points studied. The increased risk of mortality with increasing sagittal diameter was somewhat stronger when the first 10 years of follow-up were excluded and was more pronounced at lower levels of risk factors such as serum cholesterol, serum triacylglycerols, blood sugar and diastolic blood pressure and in never plus ex-smokers compared with smokers. It is indicated that the abdominal sagittal diameter is a strong predictor of mortality in younger adult men independently of age, height, body mass index and conventional risk factors for mortality such as smoking, serum lipids and blood pressure. Regional adiposity may be a less strong risk factor for mortality in older men. KW - age KW - body composition KW - body fat KW - body measurements KW - carcinoma KW - cardiovascular diseases KW - distribution KW - men KW - mortality KW - obesity KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - death rate KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406075&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Temporal association between implementation of universal precautions and a sustained, progressive decrease in percutaneous exposures to blood. AU - Beekmann, S. E. AU - Vlahov, D. AU - Koziol, D. E. AU - McShalley, E. D. AU - Schmitt, J. M. AU - Henderson, D. K. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1994/// VL - 18 IS - 4 SP - 562 EP - 569 SN - 1058-4838 AD - Beekmann, S. E.: (D.K. Henderson) Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C146, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006228. Publication Type: Journal Article. Language: English. KW - Health care workers KW - HIV infections KW - needlestick injuries KW - Prevention KW - Transmission KW - human immunodeficiency virus infections KW - Universal precautions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body mass index and mortality in Seventh-day Adventist men. A critique and re-analysis. AU - Sorkin, J. D. AU - Muller, D. AU - Andres, R. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1994/// VL - 18 IS - 11 SP - 752 EP - 754 SN - 0307-0565 AD - Sorkin, J. D.: National Institute on Aging, Epidemiology, Demography, and Biometry Program, Gateway Building, Suite 3C309, 7201 Wisconsin Avenue, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951401035. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition N2 - The study examined whether the relation between weight-adjusted-for-height (expressed as body mass index or BMI) using the BMI-at-entry and age-at-entry as opposed to BMI at entry and age-at-event (i.e., death, loss to follow-up, or end of the study) would alter the results previously reported from a population of Seventh-day Adventist American men. The subjects were 8828 non-smoking, non-drinking Seventh-day Adventist men, 30-89 years and older on entry, mean follow-up 15 years (maximum 26 years). The BMI and age reported by subjects when they were enrolled into the study were used to calculate the relation between BMI and mortality. Mortality rates in each of 5 BMI quintiles were computed by dividing the number of deaths in each quintile by the number of person-years of follow-up in the quintile. Rate ratios were computed by dividing each mortality rate by the rate in the reference quintile. The mortality rate ratios were then adjusted for the age difference between each quintile and the reference quintile. Calculations based upon age-at-enrollment rather than "age-at-event" demonstrate no increase in mortality until a BMI of 27.5 kg/m² or greater is reached rather than a progressive increase in mortality with increasing BMI. KW - body measurements KW - body weight KW - men KW - mortality KW - religion KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - death rate KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401035&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Glycemic response to stress is altered in euglycemic Pima Indians. AU - Esposito-Del Puente, A. AU - Lillioja, S. AU - Bogardus, C. AU - McCubbin, J. A. AU - Feinglos, M. N. AU - Kuhn, C. M. AU - Surwit, R. S. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1994/// VL - 18 IS - 11 SP - 766 EP - 770 SN - 0307-0565 AD - Esposito-Del Puente, A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. N1 - Accession Number: 19951401038. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - The effects of a computer-driven mental arithmetic task on blood glucose were studied in a group of 4 male and 4 female euglycaemic Caucasians and a group of 7 male and 6 female euglycaemic Pima Indians. Approximately 60% of euglycaemic Pima Indian Native Americans eventually develop type 2 diabetes, while only 5% of Caucasians develop the disease. All subjects had normal glucose tolerance. Subjects were given a standard breakfast; 2 h later, they were given a computerized mental arithmetic stress test for 10 min. Before, during and after the test, several variables were analysed, including serum concentrations of glucose, insulin, glucagon and plasma cortisol and catecholamines. Heart rate, systolic and diastolic blood pressure and all the stress hormones increased during stress and decreased during recovery in all subjects. Blood glucose consistently declined 1 h after the meal in all subjects. However, while it continued to decline following stress in 7 of 8 Caucasian subjects, it consistently increased during and following stress in 10 of 13 Pima Indians. Fasting serum glucose in Pima Indians and Caucasians was respectively 5.07 + 0.08 and 5.04 + 0.09 mM. 2-h post-prandial values were 5.63 + 0.22 and 5.48 + 0.19 mM, respectively, whereas post-stress values were 6.15 + 0.19 for Pima Indians and 5.22 + 0.20 mM for Caucasians. Both serum glucose means following stress (t = 3.1, P<0.005) and the direction of change in serum glucose in response to mental arithmetic (χ² = 8.2, P<0.01) clearly differentiated Pimas from Caucasians. The data suggest that abnormal glycaemic responsiveness to stress, even in the absence of impaired glucose tolerance, may be present in subjects at high risk of developing diabetes and may therefore be related in some way to the chain of events leading to the development of the disease. KW - blood sugar KW - diabetes KW - ethnic groups KW - mental stress KW - stress KW - sympathetic nervous system KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood glucose KW - glucose in blood KW - psychological stress KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401038&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiretroviral therapy for infection due to human immunodeficiency virus in children. AU - Pizzo, P. A. AU - Wilfert, C. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1994/// VL - 19 IS - 1 SP - 177 EP - 196 SN - 1058-4838 AD - Pizzo, P. A.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050461. Publication Type: Journal Article. Language: English. Number of References: 178 ref. KW - acquired immune deficiency syndrome KW - antiviral agents KW - children KW - HIV infections KW - treatment KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050461&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive zygomycosis due to Conidiobolus incongruus. AU - Walsh, T. J. AU - Renshaw, G. AU - Andrews, J. AU - Kwon-Chung, J. AU - Cunnion, R. C. AU - Pass, H. I. AU - Taubenberger, J. AU - Wilson, W. AU - Pizzo, P. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1994/// VL - 19 IS - 3 SP - 423 EP - 430 SN - 1058-4838 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951202970. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in 32-yr-old granulocytopenic woman from Maryland, USA, who developed rapidly progressive pneumonia and fatal pericardial zygomycosis due to C. incongruus. The microbiological characteristics, histological features and antifungal susceptibility of the isolate are described. Previously reported cases of deeply invasive zygomycosis due to Conidiobolus spp. are also reviewed. It is concluded that in immunocompromised patients, C. incongruus is an uncommon but highly invasive fungal pathogen that may be resistant to amphotericin B and can be distinguished from other Zygomycetes fungi by characteristic mycological features. KW - case reports KW - hosts KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - infections KW - opportunistic infections KW - predisposition KW - zygomycosis KW - Maryland KW - USA KW - Ancylistaceae KW - Conidiobolus KW - Entomophthoraceae KW - man KW - Ancylistaceae KW - Entomophthorales KW - Entomophthoromycotina KW - Zygomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Conidiobolus KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Conidiobolus incongruus KW - fungus KW - phycomycosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202970&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogenetic spectrum of fungi that are pathogenic to humans. AU - Kwon-Chung, K. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1994/// VL - 19 IS - Suppl. 1 SP - S1 EP - S7 SN - 1058-4838 AD - Kwon-Chung, K. J.: Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951201521. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Recent phylogenetic studies based on ribosomal RNA sequences of pathogenic fungi are discussed in relation to the classification of Pythium insidiosum, Prototheca and Pneumocystis carinii. KW - human diseases KW - infections KW - mycoses KW - phylogeny KW - pneumocystosis KW - protothecosis KW - taxonomy KW - Chlorellaceae KW - Chlorellales KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Prototheca KW - Pythiaceae KW - Pythium insidiosum KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Chlorellaceae KW - Chlorellales KW - Chlorophyta KW - algae KW - plants KW - aquatic plants KW - aquatic organisms KW - Pythium KW - Pythiaceae KW - Pythiales KW - Oomycetes KW - Oomycota KW - Mastigomycotina KW - Focus on fungal infections 3 KW - fungus KW - Peronosporomycetes KW - pythiosis KW - Straminipila KW - systematics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201521&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Administration of the antimycotic agents fluconazole and itraconazole to leukaemia patients: a comparative pharmacokinetic study. AU - Lazo de la Vega, S. AU - Volkow, P. AU - Yeates, R. A. AU - Pfaff, G. JO - Drugs under Experimental and Clinical Research JF - Drugs under Experimental and Clinical Research Y1 - 1994/// VL - 20 IS - 2 SP - 69 EP - 75 SN - 0378-6501 AD - Lazo de la Vega, S.: R. A. Yeates, Department of Infectious Diseases, National Cancer Institute, Tlalpan 14000, Mexico City, Mexico. N1 - Accession Number: 19951200017. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 84625-61-6, 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - A randomized parallel design comparative study of serum concn of fluconazole and itraconazole after oral administration of 100 mg to 20 patients with leukaemia (10 in each group) was conducted. The drugs were administered with a standard breakfast immediately before the start of chemotherapy (day 1) and on days 8 and 15. There were no significant differences (P>0.05) in the pharmacokinetic parameters of fluconazole (AUC, Cmax, Tmax) during the 3 d of the trial. It is concluded that there is no clinically important pharmacokinetic interaction between fluconazole and the chemotherapeutic agents given to this group of patients. A pharmacokinetic interaction between fluconazole and the fever suffered by some of the patients was unlikely. No significant differences (P>0.05) in the pharmacokinetic parameters of itraconazole (AUC, Cmax, Tmax) were found during the 3 d, although the statistical power of the data was low. The significantly greater variability of all pharmacokinetic parameters for itraconazole than for fluconazole and the sharp increases and decreases in AUC during the course of the trial found for some patients in the itraconazole group indicated the need for caution in this group of patients. KW - antifungal agents KW - drug therapy KW - fluconazole KW - immunocompromised hosts KW - itraconazole KW - leukaemia KW - pharmacokinetics KW - blood cancer KW - chemotherapy KW - fungistats KW - leucaemia KW - leukemia KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200017&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of Vicia faba and bran feeding on nitrosamine carcinogenesis and formation. AU - Zakhary, N. I. AU - El-Aaser, A. A. AU - Abdelwahab, A. A. AU - Fathey, S. A. AU - Aboul-Ela, F. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 21 IS - 1 SP - 59 EP - 69 SN - 0163-5581 AD - Zakhary, N. I.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 20001413430. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9001-78-9. Subject Subsets: Human Nutrition N2 - The goal of this work was to study the effect of the most common Egyptian food items, Vicia faba beans (VF) and bran, on the carcinogenicity of dibutylnitrosamine (DBN) precursors (dibutylamine and nitrite). Mice receiving DBN precursors showed a delayed gain in body weight as well as decreased protein level and 5-nucleotidase activity. Acid ribonuclease, alkaline phosphatase, and DNA level and rate of synthesis were significantly increased compared with corresponding controls. Hepatomas and bladder papillomas developed in 60% and 40% of mice, respectively, after nine months of treatment. On the other hand, administration of VF or bran, in addition to DBN precursors, lessened the damage caused by DBN precursors alone, except DNA level and rate of synthesis were elevated. Alkaline phosphatase was also elevated when bran was administered with DBN precursors. However, these elevations were still less than corresponding elevations in mice receiving DBN precursors alone. The incidence of hepatoma was also reduced to only 20% for both groups. Meanwhile, incidence of bladder papillomas was only 20% in mice receiving VF in addition to DBN precursors, and bladder papillomas were completely absent in mice receiving bran in addition to DBN precursors. In vitro studies were also performed to clarify the effect of VF or bran on diphenylnitrosamine (DPhNA) and its formation from its precursors (diphenylamine and nitrite). The study revealed that VF and bran have the ability to eliminate nitrite and DPhNA from the reaction media and to reduce the rate of formation of DPhNA from its precursors. This reaction depends on the concentration and form of VF or bran and the duration of the reaction. Thus it is concluded that some naturally occurring food items, such as VF and bran, could protect humans against the hazardous effect of nitrosamines and their precursors. KW - alkaline phosphatase KW - animal models KW - beans KW - bladder KW - body weight KW - carcinogenesis KW - carcinogens KW - faba beans KW - feeding KW - in vitro KW - nitrosamines KW - precursors KW - synthesis KW - man KW - mice KW - Vicia KW - Vicia faba KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Vicia KW - alkaline phosphomonoesterase KW - broad beans KW - fava beans KW - field beans KW - horse beans KW - tic beans KW - urinary bladder KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413430&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinol and β-carotene concentrations in skin, papillomas and carcinomas, liver, and serum of mice fed retinoic acid or β-carotene to suppress skin tumor formation. AU - Jones, C. S. AU - Sly, L. AU - Chen LiChuan AU - Ben, T. AU - Brugh-Collins, M. AU - Lichti, U. AU - Luca, L. M. de JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 21 IS - 1 SP - 83 EP - 93 SN - 0163-5581 AD - Jones, C. S.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413432. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7235-40-7, 302-79-4, 68-26-8. Subject Subsets: Human Nutrition N2 - Using 7,12-dimethylbenz[a]anthracene as the initiator and 12-O-tetradecanoyl-13-acetate as the tumor promoter on the dorsal skin of Sencar mice, we previously showed that pharmacological dietary all-trans-retinoic acid and β-carotene inhibit the conversion of papillomas to carcinomas in a two-stage system of chemical carcinogenesis. The purpose of this study was to determine the influence of dietary retinoic acid and β-carotene on retinoid and β-carotene concentrations in skin and other tissues. We were unable to measure tissue retinoic acid because of the relatively limited amount of tissue available for analysis and the fast rate of metabolism. Different dietary levels of retinoic acid or β-carotene did not influence total retinol of skin, papilloma, and carcinoma tissues, which all showed a concentration of approximately 1±0.5 µg/g wet wt. Equally refractory to dietary retinoic acid or β-carotene was serum retinol concentration. In contrast, dietary retinoic acid protected loss of liver retinol and retinyl palmitate, and β-carotene caused an increase in β-carotene and retinyl palmitate in liver but did not affect serum and liver retinol. We further investigated metabolic and functional aspects of retinoic acid in cultured mouse epidermal keratinocytes (LC-8 cells) and found that these cells actively metabolized [10,11-14C]retinoic acid to polar compounds. Isomers of retinoic acid were a minor product in the presence of cells and the major product when incubated in serum-containing medium in the absence of cells. From the functional point of view, exposure of LC-8 cells to 3×10-6 M all-trans-retinoic acid (RA) caused a 75-fold induction in tissue transglutaminase and an approximately 9-fold induction in 10-6 M RA at three days of culture. We conclude that retinoic acid spares endogenous retinol and that β-carotene greatly enhances liver retinyl palmitate levels. Moreover we show that although mouse epidermal cells metabolize retinoic acid at a very high rate, they respond functionally by induction of tissue transglutaminase activity. Because this enzyme has been suggested to be involved in programmed cell death, we are presently investigating the possibility that it may be involved in the inhibition of carcinogenesis in mice fed pharmacological doses of RA. KW - animal models KW - beta-carotene KW - carcinogenesis KW - carcinoma KW - diets KW - inhibition KW - isomers KW - liver KW - promoters KW - retinoic acid KW - retinol KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - promoter region KW - promoter sequences KW - tretinoin KW - vitamin A KW - vitamin A acid KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413432&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Soy intake and cancer risk: a review of the in vitro and in vivo data. AU - Messina, M. J. AU - Persky, V. AU - Setchell, K. D. R. AU - Barnes, S. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 21 IS - 2 SP - 113 EP - 131 SN - 0163-5581 AD - Messina, M. J.: National Cancer Institute, National Institutes of Health, (Bethesda, MD), USA. N1 - Accession Number: 20001413395. Publication Type: Journal Article. Language: English. Number of References: 112 ref. Registry Number: 60-18-4. Subject Subsets: Human Nutrition N2 - International variations in cancer rates have been attributed, at least in part, to differences in dietary intake. Recently, it has been suggested that consumption of soyfoods may contribute to the relatively low rates of breast, colon, and prostate cancers in countries such as China and Japan. Soybeans contain a number of anticarcinogens, and a recent National Cancer Institute workshop recommended that the role of soyfoods in cancer prevention be investigated. In this review, the hypothesis that soy intake reduces cancer risk is considered by examining relevant in vitro, animal, and epidemiological data. Soybeans are a unique dietary source of the isoflavone genistein, which possesses weak estrogenic activity and has been shown to act in animal models as an antiestrogen. Genistein is also a specific inhibitor of protein tyrosine kinases; it also inhibits DNA topoisomerases and other critical enzymes involved in signal transduction. In vitro, genistein suppresses the growth of a wide range of cancer cells, with IC50 values ranging from 5 to 40 µM (1-10 µg/ml). Of the 26 animal studies of experimental carcinogenesis in which diets containing soy or soybean isoflavones were employed, 17 (65%) reported protective effects. No studies reported soy intake increased tumor development. The epidemiological data are also inconsistent, although consumption of nonfermented soy products, such as soymilk and tofu, tended to be either protective or not associated with cancer risk; however, no consistent pattern was evident with the fermented soy products, such as miso. Protective effects were observed for both hormone- and nonhormone-related cancers. While a definitive statement that soy reduces cancer risk cannot be made at this time, there is sufficient evidence of a protective effect to warrant continued investigation. KW - animal models KW - carcinogenesis KW - colon KW - diets KW - epidemiology KW - in vitro KW - isoflavones KW - kinases KW - models KW - neoplasms KW - prevention KW - prostate KW - protection KW - reviews KW - soyabeans KW - tofu KW - tyrosine KW - China KW - Japan KW - Glycine (Fabaceae) KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Developed Countries KW - OECD Countries KW - bean curd KW - cancers KW - People's Republic of China KW - risks KW - soyabean curd KW - soybean curd KW - soybeans KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413395&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The relations between cervical cancer and serological markers of nutritional status. AU - Potischman, N. AU - Hoover, R. N. AU - Brinton, L. A. AU - Swanson, C. A. AU - Herrero, R. AU - Tenorio, F. AU - Britton, R. C. de AU - Gaitan, E. AU - Reeves, W. C. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 21 IS - 3 SP - 193 EP - 201 SN - 0163-5581 AD - Potischman, N.: Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413216. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7235-40-7, 57-88-5, 502-65-8, 68-26-8. Subject Subsets: Human Nutrition N2 - We evaluated whether differences in serological nutrient indicators between cases and controls were likely to be due to different usual levels for cases or to altered metabolism due to disease. Blood samples obtained as part of a case-control study of invasive cervical cancer conducted in Latin America were evaluated for case-control differences and for trends with stage of disease. Serum α- and β-carotene, cryptoxanthin, and α- and γ-tocopherol showed no trend with extent of disease, although Stage IV cases had lower α- and β-carotene values than did other cases. A slight trend of decreasing values with stage was observed for serum retinol, lycopene, and lutein. For cholesterol and triglyceride concentrations, an inverse trend was observed with stage of disease, which suggested a clinical effect of the disease on blood lipids. Adjustment for smoking, alcohol intake, or oral contraceptive use did not alter observed relations, nor was there evidence that the altered blood nutrient levels differed by histological type. These data suggest that serum values for some carotenoids from Stage I, II, and III cervical cancer are suitable for aetiological studies, but spurious results may be obtained if late-stage cases are included. Evidence of trends with severity of disease for cholesterol and triglycerides, and possibly for retinol, lycopene, and lutein, suggest that special attention be given to disease effects of these nutrients in studies of cervical cancer. KW - alcohol intake KW - beta-carotene KW - blood KW - blood chemistry KW - blood lipids KW - carotenoids KW - cervix KW - cholesterol KW - evaluation KW - lipids KW - lycopene KW - neoplasms KW - nutrients KW - nutritional state KW - oral contraceptives KW - retinol KW - tobacco smoking KW - triacylglycerols KW - vitamins KW - women KW - America KW - Latin America KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - alcohol consumption KW - axerophthol KW - cancers KW - lipins KW - nutritional status KW - tetraterpenoids KW - triglycerides KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413216&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors and second primary cancers: a follow-up of oral and pharyngeal cancer patients. AU - Day, G. L. AU - Shore, R. E. AU - Blot, W. J. AU - McLaughlin, J. K. AU - Austin, D. F. AU - Greenberg, R. S. AU - Liff, J. M. AU - Preston-Martin, S. AU - Sarkar, S. AU - Schoenberg, J. B. AU - Fraumeni, J. F., Jr. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 21 IS - 3 SP - 223 EP - 232 SN - 0163-5581 AD - Day, G. L.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413219. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 50-81-7, 68-26-8. Subject Subsets: Human Nutrition N2 - To investigate the possible relationship between dietary factors and the development of multiple primary cancer, a nested case-control study was carried out within a cohort of 1090 oral and pharyngeal cancer patients. This patient group, enrolled in 1984-1985 in a population-based case-control study conducted in four (state of New Jersey, metropolitan Atlanta, Los Angeles County and 2 counties in the San Francisco Bay area) areas of the United States, was followed up through June 1989 for the occurrence of second primary cancer. Information on a number of risk factors, including diet, ascertained from interviews conducted at baseline (1984-1985) and at follow-up were compared between 80 patients with histologically confirmed second primary cancers (39% in the upper aerodigestive tract, 32% in the lung, 29% elsewhere) and 189 sex- and survival-matched control patients free of second cancers. Although few significant trends emerged, the results were suggestive of a protective effect provided by higher intake of vegetables. Risk of second primary cancers was 40-60% lower among those with the highest levels of intake for total vegetables and most vegetable subgroups, including dark yellow, cruciferous, and green leafy vegetables and legumes. Risks were also nonsignificantly lower among those with high consumption of vitamin C and carotenoids, with the adverse effects of alcohol being most evident among heavy drinkers with low vitamin C or carotenoid intake. There was also some evidence of an interaction between smoking and vitamin C consumption, but numbers of nonsmokers were small. Among other dietary factors considered, positive associations were found with increasing consumption of meats, liver, and retinol. The findings suggest that dietary factors contribute along with alcohol and smoking to the excess risks of second primary cancers among patients with oral and pharyngeal cancers. KW - adverse effects KW - alcohol intake KW - ascorbic acid KW - carotenoids KW - consumption KW - diet studies KW - diets KW - drinkers KW - intake KW - interactions KW - leafy vegetables KW - legumes KW - liver KW - lungs KW - meat KW - mouth KW - neoplasms KW - pharynx KW - protection KW - retinol KW - risk factors KW - vegetables KW - USA KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - alcohol consumption KW - axerophthol KW - cancers KW - green vegetables KW - tetraterpenoids KW - United States of America KW - vegetable crops KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413219&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Daily observation of antibody levels among dengue patients detected by enzyme-linked immunosorbent assay (ELISA). AU - Ruechusatsawat, K. AU - Morita, K. AU - et al. AU - Tanaka, M. ( JO - Japanese Journal of Tropical Medicine and Hygiene JF - Japanese Journal of Tropical Medicine and Hygiene Y1 - 1994/// VL - 22 IS - 1 SP - 9 EP - 12 SN - 0304-2146 AD - Ruechusatsawat, K.: Arbovirus Research Unit, Virus Institute, National Institutes of Health, Nonthaburi, Thailand. N1 - Accession Number: 19942027189. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Tropical Diseases N2 - Serial serum specimens from 48 dengue patients admitted to a hospital [in Thailand] on day 2, day 3, or day 4 post onset were examined sequentially by ELISA for laboratory diagnosis according to the criteria set by Innis et al., [American Journal of Tropical Medicine and Hygiene, 40, 418]. Cumulative ELISA positive rates among forty secondary dengue infection patients were 95% and 100% at day 6 and day 7 post onset, respectively while the ELISA positive rates at day 3, day 4, and day 5 were 17.5%, 37.5%, and 75%. Cumulative ELISA positive rates among eight primary dengue patients were 87.5% and 100% at day 6 and day 7 post onset, while the rates at day 4 and day 5 were 12.5% and 50%. Thus, in order to achieve better diagnostic efficiency according to the criteria, convalescent sera should be taken after the 6th day from the onset of the disease. Four out of 74 secondary infection patients, corresponding to 5% of the patients, showed poor response of dengue-specific IgM antibody (less than 10 units) even when discharged, indicating that both IgG and IgM examinations are necessary in secondary dengue infection. AS<new para>ADDITIONAL ABSTRACT:<new para>Serial serum specimens from 48 dengue patients admitted to hospital in Thailand on days 2, 3 or 4 post onset were examined sequentially by ELISA for laboratory diagnosis according to the criteria set by B.L. Innis et al. (1993) [American Journal of Tropical Medicine and Hygiene, 40: 418-427]. Cumulative ELISA positive rates among 40 secondary dengue infection patients were 95% and 100% at days 6 and 7 post onset, respectively, while the ELISA positive rates at days 3, 4 and 5 were 17.5%, 37.5% and 75%. Cumulative ELISA positive rates among 8 primary dengue patients were 87.5% and 100% at days 6 and 7 post onset, while the rates at days 4 and 5 were 12.5% and 50%. Thus, in order to achieve better diagnostic efficiency according to the criteria, convalescent sera should be taken after the 6th day from the onset of the disease. 4 out of 74 secondary patients, corresponding to 5% of the patients, showed poor response of dengue-specific IgM antibody (<10 units) even when discharged, indicating that both IgG and IgM examinations are necessary in secondary dengue infection. KW - antibodies KW - arboviruses KW - Dengue KW - diagnosis KW - ELISA KW - human diseases KW - IgG KW - IgM KW - immune response KW - immunodiagnosis KW - immunoglobulins KW - serology KW - viral diseases KW - Asia KW - Thailand KW - dengue virus KW - Flavivirus KW - man KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - arthropod-borne viruses KW - enzyme linked immunosorbent assay KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - serological diagnosis KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027189&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis. AU - Ji, J. AU - Hoffmann, J. S. AU - Loeb, L. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1994/// VL - 22 IS - 1 SP - 47 EP - 52 SN - 0305-1048 AD - Ji, J.: (L. Loeb) Laboratory of Molecular Genetics, National Institute of Aging, NIH, Baltimore, MD 21224, USA. N1 - Accession Number: 19942006519. Publication Type: Journal Article. Language: English. Registry Number: 9068-38-6. KW - env gene KW - Mutations KW - Nucleic acids KW - Reverse transcriptase KW - Synthesis KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006519&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Folate and cancer: a review of the literature. AU - Glynn, S. A. AU - Albanes, D. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 22 IS - 2 SP - 101 EP - 119 SN - 0163-5581 AD - Glynn, S. A.: National Cancer Institute, Cancer Prevention Studies Branch, National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 20001413375. Publication Type: Journal Article. Language: English. Number of References: 97 ref. Registry Number: 59-30-3, 12001-76-2. Subject Subsets: Human Nutrition N2 - Folate, a water-soluble vitamin, part of the vitamin B complex, plays an important role in methylation reactions and DNA/RNA synthesis. This review examines the experimental and epidemiological evidence for the association between folate status and risk of cancer. Data have accumulated indicating that low folate status may promote carcinogenesis. Low folate levels are associated with cytogenetic abnormalities in vivo and in vitro. Findings from animal studies are conflicting and suggest that the effect of folate on neoplasia depends on factors such as the animal and tumor model, the type, timing, dose, and length of application of carcinogen, the stage of carcinogenesis, and the level and form of folate administered. Epidemiological studies examined the association between folate and cancer of the cervix, colorectum, lung, esophagus, and brain and suggest that low folate status may play an important role early in the neoplastic process. The potential for inhibition of precursor lesions in the cervix and colorectum, namely, cervical intraepithelial neoplasia and adenomatous polyps, respectively, is of particular interest. Additional research designed to clarify the role of folate in carcinogenesis is warranted. KW - brain KW - carcinogenesis KW - cervix KW - epidemiology KW - folic acid KW - in vitro KW - inhibition KW - lesions KW - lungs KW - neoplasms KW - nutrition KW - oesophagus KW - reviews KW - synthesis KW - vitamin B complex KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cerebrum KW - esophagus KW - folacin KW - folate KW - vitamin B KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413375&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of soybean, Vicia faba, and vitamin C on the carcinogenicity of DMBA. AU - El-Aaser, A. A. AU - Zakhary, N. I. AU - El-Guindy, S. M. AU - Hafiez, A. R. A. AU - Halawa, F. AU - Mokhtar, N. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 22 IS - 2 SP - 195 EP - 200 SN - 0163-5581 AD - El-Aaser, A. A.: Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 20001413382. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9001-78-9, 50-81-7. Subject Subsets: Human Nutrition N2 - A single dose of 10 mg of 7,12-dimethylbenz[a]anthracene (DMBA), administered to rats through intragastric intubation, was sufficient to induce many biochemical and histopathological changes in their mammary tissue. Significant increases were observed in the activity levels of the enzymes acid ribonuclease, 5-nucleotidase, alkaline phosphatase, and β-glucuronidase in mammary tissue homogenates of DMBA-treated rats after an experimental period of five months. Histopathological studies of the mammary tissue also revealed malignant epithelial tumors (cribriform carcinoma) induced among 85% of the treated rats, with an incidence of 4 tumors in 12 mammary glands. Nevertheless, administration of 30% soybean in the diet of rats or 5,000 ppm ascorbic acid in their drinking water in addition to DMBA revealed a significant chemoprotective effect against the carcinogenesis induced by DMBA alone. This chemoprotective effect was demonstrated by the normalization of the activity levels of the enzymes studied in mammary tissue homogenates, because most of the enzymes were maintained at near the levels in the control animals. The incidence and number of tumors were also decreased. Cribriform carcinoma was observed in 50% of the rats, and the incidence of the affected glands was 2 in 12 mammary glands among both groups. On the other hand, a less chemoprotective effect was observed due to Vicia faba administration. KW - alkaline phosphatase KW - animal models KW - ascorbic acid KW - carcinogenesis KW - carcinogens KW - carcinoma KW - diet KW - drinking water KW - faba beans KW - mammary glands KW - mammary tissue KW - neoplasms KW - soyabeans KW - Glycine (Fabaceae) KW - rats KW - Vicia KW - Vicia faba KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Vicia KW - alkaline phosphomonoesterase KW - broad beans KW - cancers KW - fava beans KW - field beans KW - horse beans KW - soybeans KW - tic beans KW - vitamin C KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Importance of supplemental vitamin C in determining serum ascorbic acid in controls from a cervical cancer case-control study: implications for epidemiological studies. AU - Rashmi Sinha AU - Frey, C. M. AU - Kammerer, W. G. AU - McAdams, M. J. AU - Norkus, E. P. AU - Ziegler, R. G. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1994/// VL - 22 IS - 3 SP - 207 EP - 217 SN - 0163-5581 AD - Rashmi Sinha: Epidemiology and Biostatistics Program, Division of Cancer Etiology, Nutritional Epidemiology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413307. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Classification of individuals by their ascorbic acid intake was investigated in 493 control subjects from a cervical cancer case-control study. The influence of dietary and supplemental sources of ascorbic acid, and demographic and life-style factors, on serum ascorbic acid were examined. Usual dietary intakes of ascorbic acid were determined from a food frequency questionnaire and recent intakes from a 24-h recall taken at the time of blood collection. Vitamin supplement information was obtained at both times. Blood samples were obtained from 361 white (72% of those interviewed) and 132 black (56% of those interviewed) subjects. In a regression analysis, the factors found to predict serum ascorbic acid were total recent ascorbic acid intake, an indicator variable for supplement use, body mass index, number of cigarettes smoked per day, race, education, and age. Higher levels of serum ascorbic acid were found among older nonsmoking highly educated leaner white women. Consideration of supplements, in addition to dietary sources of ascorbic acid, improved correlation coefficients between serum ascorbic acid and usual ascorbic acid intake from 0.19 to 0.32 and between serum ascorbic acid and recent intake from 0.36 to 0.56. While only a 2-fold difference between the first and fourth quartiles of serum ascorbic acid was observed using recent dietary ascorbic acid without supplements, this range increased 6-fold with addition of supplement data. Epidemiological studies should consider the use of total ascorbic acid intakes from supplement and food sources to permit accurate classification of individuals. KW - anthropometric dimensions KW - ascorbic acid KW - blood KW - body measurements KW - cervix KW - classification KW - diet studies KW - diets KW - education KW - epidemiology KW - height KW - intake KW - neoplasms KW - questionnaires KW - sources KW - supplements KW - vitamin supplements KW - weight KW - anthropometric measurements KW - cancers KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413307&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies. AU - Le, S. Y. AU - Pattabiraman, N. AU - Maizel, J. V. Jr JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1994/// VL - 22 IS - 19 SP - 3966 EP - 3976 SN - 0305-1048 AD - Le, S. Y.: Laboratory of Mathematical Biology, Division of Cancer Biology, Diagnosis and Centers, National Cancer Institute, NIH, Frederick, MD 21702, USA. N1 - Accession Number: 19952001047. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - molecular biology KW - regulatory genes KW - structure KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001047&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Solid phase assays for the detection of inhibitors of HIV reverse transcriptase. AU - Gause, G. G. AU - Gonda, M. A. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1994/// VL - 22 IS - 19 SP - 4018 EP - 4019 SN - 0305-1048 AD - Gause, G. G.: Laboratory of Cell and Molecular Structure, Program Resources, Inc.\DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, PO Box B, Frederick, MD 21702, USA. N1 - Accession Number: 19952001314. Publication Type: Journal Article. Language: English. Registry Number: 9068-38-6. KW - antiviral agents KW - assays KW - enzyme activity KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - reverse transcriptase KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001314&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3′-processing and choice of nucleophile by HIV-1 integrase. AU - Mazumder, A. AU - Gupta, M. AU - Pommier, Y. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1994/// VL - 22 IS - 21 SP - 4441 EP - 4448 SN - 0305-1048 AD - Mazumder, A.: (Y. Pommier) Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 37, Room 5C25, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001566. Publication Type: Journal Article. Language: English. KW - analysis KW - genomes KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - mutations KW - processing KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - integrase KW - long terminal repeat KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001566&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic mapping of the mouse prosaposin gene (Psap) to mouse chromosome 10. AU - Kozak, C. A. AU - Adamson, M. C. AU - Horowitz, M. JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1994/// VL - 23 IS - 2 SP - 508 EP - 510 SN - 0888-7543 AD - Kozak, C. A.: Laboratory of Molecular Microbiology, National Institutes of Health, Building 4, Room 329, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950104243. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Agricultural Biotechnology N2 - The prosaposin gene (Psap) was previously cloned from a mouse brain cDNA library. Psap was found to be linked to 6 markers on chromosome 10 and located between pore-forming protein (Pfp) and zinc finger protein, autosomal (Zfa) genes. This region of mouse chromosome 10 is syntenic with human chromosome 10q21-q22. KW - biotechnology KW - gene mapping KW - pores KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - prosaposin KW - synteny KW - zinc finger KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950104243&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Child health and nutrition: obesity and high blood cholesterol. AU - Ernst, N. D. AU - Obarzanek, E. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1994/// VL - 23 IS - 4 SP - 427 EP - 436 SN - 0091-7435 AD - Ernst, N. D.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951407607. Publication Type: Journal Article. Language: English. Number of References: 93 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Available data confirm that obesity and high blood cholesterol levels in children from the USA are higher than optimal and that the benefit of reducing the prevalence of these conditions in childhood will be realized in adulthood. Current National Heart, Lung and Blood Institute-supported research and education activities focus on unanswered questions about the childhood predictors of transition to the obese state and the feasibility, efficacy and safety of long-term dietary intervention in children. The effects of school-based interventions including classroom curriculum and school environmental changes related to food intake, physical activity, tobacco use and dissemination of materials that promote nutrition and cardiovascular health in children and adolescents are discussed. KW - blood KW - children KW - cholesterol KW - obesity KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407607&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary intake patterns and sociodemographic factors in the atherosclerosis risk in communities study. AU - Shimakawa, T. AU - Sorlie, P. AU - Carpenter, M. A. AU - Dennis, B. AU - Tell, G. S. AU - Watson, R. AU - Williams, O. D. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1994/// VL - 23 IS - 6 SP - 769 EP - 780 SN - 0091-7435 AD - Shimakawa, T.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951406391. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - Dietary intake assessed by a food frequency questionnaire was examined in relation to race, sex and educational attainment using baseline data obtained from randomly selected samples of 15 800 middle-aged black and white men and women who participated in the Atherosclerosis Risk in Communities Study (USA). In almost all comparisons, higher educational attainment was associated with recommended dietary intake patterns-lower per energy intakes of meats, eggs, chicken with skin and whole milk and higher intakes of fruits, vegetables, fish, chicken without skin and low-fat milk. As expected from these food intake patterns, higher educational attainment was associated with lower intakes of saturated fatty acid and cholesterol and with higher intakes of dietary fibre and various micronutrients. Compared with women's diets, men's diets were slightly more atherogenic (in whites only) based upon Keys score and had lower micronutrient levels. Although there were large differences in the food intakes between blacks and whites, the differences in nutrient intakes were generally smaller. However, intakes of cholesterol and vitamin A were somewhat higher and intakes of saturated fatty acid, calcium and potassium were lower among blacks than in whites. This community-based study clearly demonstrated that regardless of race and sex, high educational attainment is associated with recommended dietary intake patterns. Continuing efforts to improve general educational level and to promote healthy dietary habits among those with low socioeconomic status are warranted. KW - atherosclerosis KW - diet KW - diet studies KW - education KW - ethnic groups KW - heart diseases KW - men KW - risk KW - socioeconomic status KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - arteriosclerosis KW - coronary diseases KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406391&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Febrile illness caused by parasites. AU - Mahanty, S. JO - Pediatric Annals JF - Pediatric Annals Y1 - 1994/// VL - 23 IS - 8 SP - 398 EP - 404 SN - 0090-4481 AD - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950809242. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Helminthology; Protozoology N2 - In this review article it is shown that almost all protozoal and helminth parasites that are associated with febrile illness are either tissue-invasive or reside in the bloodstream. A practical approach to evaluating fever in individuals presenting with suspected parasitic infections involves the division of the patients into 2 groups: those with or without accompanying eosinophilia. The importance of accurate historical records, targeted clinical examination, appropriate laboratory investigations, and an evaluation of the individual's immunological status are emphasized. Appropriate diagnostic tests for a number of parasitic diseases are discussed. It is shown that, in general, when a patient with a suspected parasitic disease presents with eosinophilia, a helminth infection should be expected; when eosinophilia is absent, then a protozoal infection is more likely. KW - blood KW - diagnosis KW - eosinophilia KW - fever KW - helminthoses KW - helminths KW - human diseases KW - parasites KW - parasitoses KW - pathology KW - patients KW - protozoal infections KW - reviews KW - tissues KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - parasitic diseases KW - parasitic infestations KW - parasitic worms KW - parasitosis KW - protozoal diseases KW - pyrexia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809242&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Eosinophilia caused by parasites. AU - Mawhorter, S. D. JO - Pediatric Annals JF - Pediatric Annals Y1 - 1994/// VL - 23 IS - 8 SP - 405 EP - 413 SN - 0090-4481 AD - Mawhorter, S. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA. N1 - Accession Number: 19950809243. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Helminthology N2 - Eosinophilia associated with parasitic infections is reviewed and shown to be associated specifically with tissue invasion and the migration of helminths, the degree of eosinophilia being proportional to the degree of tissue invasion. Eosinophilia is defined as an absolute count of >500 eosinophils/mm³ of peripheral blood, and immune mechanisms are proposed. The helminth parasites commonly associated with eosinophilia are listed, and the value of identifying eosinophilia as a screening test for various helminthoses is discussed. The importance of accurate historical records, clinical examination and appropriate laboratory tests in the evaluation of patients suspected of having parasitic infections is emphasized, with emphasis on eosinophilia-inducing parasitic infections that can be acquired in the USA. KW - blood KW - diagnosis KW - eosinophilia KW - eosinophils KW - helminthoses KW - helminths KW - human diseases KW - immune response KW - immunology KW - parasite migration KW - parasites KW - reviews KW - screening KW - tissues KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - eosinophil leukocytes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - screening tests KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809243&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasitic causes of diarrhea. AU - Kenney, R. T. JO - Pediatric Annals JF - Pediatric Annals Y1 - 1994/// VL - 23 IS - 8 SP - 414 EP - 422 SN - 0090-4481 AD - Kenney, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950809244. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology; Helminthology N2 - In a review of parasitic causes of chronic diarrhoea, it is shown that indigenous parasites remain a problem in several areas of the USA. The protozoa responsible for most cases include Giardia lamblia [G. duodenalis], Entamoeba histolytica, Balantidium coli, Cryptosporidium parvum, Enterocytozoon bieneusi and Blastocystis hominis. The helminths responsible include Trichuris trichiura, Trichinella spiralis, Strongyloides stercoralis, Schistosoma and Ancylostoma caninum. The pathology, clinical manifestations and treatment of each infection are reviewed, and concern is expressed that most antidiarrhoeal compounds are not approved for children younger than 2-3 years because of the higher risk of adverse effects. This has compromised treatment since parasites transmitted by the faecal-oral route are particularly troublesome in institutional settings and day-care centres for young children. KW - child care KW - children KW - day care centres KW - diagnosis KW - diarrhoea KW - gastrointestinal diseases KW - helminthoses KW - helminths KW - human diseases KW - parasites KW - pathology KW - protozoal infections KW - reviews KW - symptoms KW - treatment KW - USA KW - Ancylostoma caninum KW - Balantidium coli KW - Blastocystis hominis KW - Cryptosporidium parvum KW - Enoplida KW - Entamoeba histolytica KW - Enterocytozoon bieneusi KW - Giardia duodenalis KW - man KW - protozoa KW - Rhabditida KW - Schistosoma KW - Strongyloides stercoralis KW - Trichinella spiralis KW - Trichuris trichiura KW - Ancylostoma KW - Ancylostomatidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Balantidium KW - Balantidiidae KW - Vestibuliferida KW - Ciliophora KW - Protozoa KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Cryptosporidium KW - Cryptosporidiidae KW - Eucoccidiorida KW - Apicomplexa KW - Entamoeba KW - Endamoebidae KW - Enterocytozoon KW - Enterocytozoonidae KW - Microspora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - Strongyloides KW - Strongyloididae KW - Trichinella KW - Trichinellidae KW - Trichinellida KW - Dorylaimia KW - Enoplea KW - Trichuris KW - Trichuridae KW - Enoplia KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Adenophorea KW - day care centers KW - day centres KW - diarrhea KW - nematodes KW - parasitic worms KW - protozoal diseases KW - scouring KW - Secernentea KW - Strigeida KW - Strongylida KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809244&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Psychosocial work environment and health in U.S. Metropolitan areas: a test of the demand-control and demand-control-support models. AU - Muntaner, C. AU - Schoenbach, C. JO - International Journal of Health Services JF - International Journal of Health Services Y1 - 1994/// VL - 24 IS - 2 SP - 337 EP - 353 SN - 0020-7314 AD - Muntaner, C.: Department of Health and Human Services, National Institutes of Health, Federal Building, Room B1A-12, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050225. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Public Health KW - Occupational health KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - metropolitan areas KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050225&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hypertrehalosemic hormone effects on transcriptional activity in the fat body of the cockroach, Blaberus discoidalis. AU - Lee YingHue AU - Keeley, L. L. JO - Insect Biochemistry and Molecular Biology JF - Insect Biochemistry and Molecular Biology Y1 - 1994/// VL - 24 IS - 4 SP - 357 EP - 362 SN - 0965-1748 AD - Lee YingHue: Room 3E24, Building 37, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950500050. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 14875-96-8. Subject Subsets: Medical & Veterinary Entomology N2 - Gene expression was examined in the fat body of adult males of B. discoidalis in response to the hypertrehalosaemic hormone (HTH). HTH regulates a natural peak of haeme synthesis in the fat body at day 4 of adult life. Inhibition of transcriptional activity by α-amanitin suppressed both the natural increase in haeme biosynthesis at day 4, and the increase that was induced in decapitated insects by HTH administration. In contrast, the regimen of α-amanitin treatments that suppressed HTH-responsive haeme biosynthesis had no effect on the ability of HTH to increase haemolymph carbohydrate. HTH administration to decapitated animals produced a 25% increase in total fat body RNA and a 3-fold increase in [3H]uridine incorporation. In vitro translation of fat body RNA showed that HTH increased the synthesis of polypeptides at 24, 60 and 77 kDa. The results suggest that HTH affects fat body haeme synthesis through gene expression, and evidence was obtained for 3 polypeptides that increase in the fat body in response to HTH. KW - arthropod hormones KW - biochemistry KW - fat body KW - gene expression KW - haem KW - metabolism KW - molecular genetics KW - Blaberidae KW - Blaberus discoidalis KW - Blattaria KW - Dictyoptera KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Blaberus KW - Blaberidae KW - biochemical genetics KW - Blattodea KW - heme KW - hypertrehalosaemic hormone KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950500050&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of drug-related genotypic changes in HIV-1 from serum using the selective polymerase chain reaction. AU - Anderson, B. D. AU - Shirasaka, T. AU - Kojima, E. AU - Yarchoan, R. AU - Mitsuya, H. JO - Antiviral Research JF - Antiviral Research Y1 - 1994/// VL - 25 IS - 3/4 SP - 245 EP - 258 SN - 0166-3542 AD - Anderson, B. D.: Experimental Retrovirology Section, Medicine Branch, Division of Cancer Treatment, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005498. Publication Type: Journal Article. Language: English. Number of References: 23 ref. KW - analogues KW - antiviral agents KW - diagnosis KW - drug resistance KW - HIV infections KW - human diseases KW - mutations KW - nucleoside analogues KW - nucleosides KW - polymerase chain reaction KW - therapy KW - treatment KW - analogs KW - human immunodeficiency virus infections KW - nucleoside analogs KW - PCR KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005498&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Formation of a minichromosome in Cryptococcus neoformans as a result of electroporative transformation. AU - Varma, A. AU - Kwon-Chung, K. J. JO - Current Genetics JF - Current Genetics Y1 - 1994/// VL - 26 IS - 1 SP - 54 EP - 61 SN - 0172-8083 AD - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201229. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A minichromosome of approx. 270 kb was generated following complementation using electroporative transformation of a ura5 mutant strain of C. neoformans with the plasmid pURA5g2. The minichromosome occurred at a relatively high (>20%) frequency in transformants that were stable for uracil prototrophy. The minichromosome was maintained in linear form as a large extrachromosomal element of the normal karyotype. Gel-purified DNA from the minichromosome readily transformed the ura5 mutant of C. neoformans. Southern-blot analysis of the minichromosome revealed the presence of multiple copies of the URA5 gene and ribosomal DNA sequences, in addition to containing telomere-like sequence repeats. The minichromosome was transmitted through mitosis and meiosis with extremely-high fidelity. KW - chromosomes KW - genetics KW - transformation KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201229&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variability in percent energy from fat throughout the day: implications for application of total diet goals. AU - Ballard-Barbash, R. AU - Thompson, F. E. AU - Graubard, B. I. AU - Krebs-Smith, S. M. JO - Journal of Nutrition Education JF - Journal of Nutrition Education Y1 - 1994/// VL - 26 IS - 6 SP - 278 EP - 283 SN - 0022-3182 AD - Ballard-Barbash, R.: Applied Research Branch,Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951403095. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - In spite of the general agreement that dietary recommendations apply to the diet over time, the quantitative values for total and saturated fat have been used in establishing federal policy related to intakes for a single day, meal and even an individual food. Application of these recommendations uniformly to meals across a day implies that fat intake is uniform throughout the day. This analysis of the 1985 Continuing Survey of Food Intakes by Individuals demonstrates that percent energy intake from fat across eating occasions within a day is not uniform. Percent energy intake from total and saturated fat is lower at the morning meals and at snacks among women at all amounts of fat consumption, suggesting that fat is restricted more often at these 2 eating occasions. Intake of total and saturated fat was also more variable at these 2 eating occasions. These findings suggest that restricting fat intake at these eating occasions and liberalizing fat intake at midday and evening meals occurs commonly and may be an effective fat-reduction strategy. Daily variability in percent energy from fat should be considered in designing dietary fat reduction interventions and in applying quantitative recommendations for percent energy from total and saturated fat in nutrition guidance directed to individual meals. KW - diet KW - energy intake KW - fats KW - guidelines KW - nutrition KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - recommendations KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403095&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Radiation as adjunctive therapy to cystectomy for bladder cancer: is there a difference for bilharzial association? AU - Zaghloul, M. S. T2 - International Journal of Radiation Oncology Biology Physics JO - International Journal of Radiation Oncology Biology Physics JF - International Journal of Radiation Oncology Biology Physics Y1 - 1994/// VL - 28 IS - 3 SP - 783 EP - 783 SN - 0360-3016 AD - Zaghloul, M. S.: Radiotherapy Department, National Cancer Institute, El Khalig, Cairo, Egypt. N1 - Accession Number: 19950803551. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Subject Subsets: Helminthology N2 - Following the article by Reisinger et al. in International Journal of Radiation, Oncology and Biological Physics (1993) 25, 153-154 on the survival of bladder cancer patients treated with cystectomy and adjuvant radiotherapy, the results of this treatment are compared in patients with schistosomal and non-schistosomal bladder cancer. The main differences appeared to be in the late presentation of bladder cancer in patients with Schistosoma infection, thought to be due to the overlap of schistosomal and neoplastic symptoms, the predominance of the squamous variety of neoplasm, the higher male predominance, and the younger age group at presentation. The effect of these differences on the management and treatment of cases of bladder cancer are discussed. KW - bladder diseases KW - carcinoma KW - helminths KW - human diseases KW - neoplasms KW - parasites KW - pathology KW - radiotherapy KW - schistosomiasis KW - surgical operations KW - treatment KW - Digenea KW - man KW - Schistosoma KW - Schistosomatidae KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - cancers KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803551&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alterations in mRNA expression of duodenal 1,25-dihydroxyvitamin D3 receptor and vitamin D-dependent calcium binding protein in aged Wistar rats. AU - Liang, C. T. AU - Barnes, J. AU - Imanaka, S. AU - Luca, H. F. de JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1994/// VL - 29 IS - 2 SP - 179 EP - 186 SN - 0531-5565 AD - Liang, C. T.: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19951410499. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 32222-06-3, 1406-16-2. Subject Subsets: Human Nutrition N2 - The steady state mRNA levels of duodenal calcitriol receptor and calcium binding protein (CaBP) were examined in both adult (6) and old (24-month-old) rats. 1 major band of 4.4 kb for calcitriol receptor mRNA was identified. The size of the transcript was not affected by age. The content of calcitriol receptor mRNA (normalized with poly(A) +RNA) decreased 23% in the aged as compared to the adult rat. The expression of CaBP was also examined. A single band of 0.6 kb was observed for CaBP mRNA. The size of CaBP mRNA was not altered with age. However, the abundance of CaBP mRNA (normalized with poly(A) +RNA) was reduced 20% in the senescent rat. Thus, results were consistent with previous findings that the number of calcitriol receptors and the level of CaBP declined in the aged rat. However, the precise mechanism leading to the age-related deficit in mRNA expression remains to be elucidated. KW - age KW - aging KW - calcitriol KW - calcium binding proteins KW - duodenum KW - gene expression KW - receptors KW - vitamin D KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - ageing KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410499&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical and pharmacological factors causing induction and suppression of germination of Trichosporon beigelii. AU - Walsh, T. J. AU - Kelly, P. AU - Peebles, R. AU - Lee, J. AU - Lecciones, J. AU - Pizzo, P. A. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1994/// VL - 32 IS - 2 SP - 123 EP - 132 SN - 0268-1218 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200702. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Biochemical and pharmacological factors that may regulate germination of T. beigelii were investigated. Germination was significantly enhanced by temp. of 37°C, chemically defined cell culture media such as RPMI-1640, plasma, physiological pH, N-acetylglucosamine and proline. N-acetylglucosamine was equivalent to proline in inducing germination. Germination was suppressed by high concn of glucose, increasing inocula, low pH and amphotericin B at achievable serum concn. It is concluded that many of the factors regulating germination of T. beigelii are similar to those for Candida albicans. KW - germination KW - morphogenesis KW - Trichosporon beigelii KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200702&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum D-arabinitol measured by automated quantitative enzymatic assay for detection and therapeutic monitoring of experimental disseminated candidiasis: correlation with tissue concentrations of Candida albicans. AU - Walsh, T. J. AU - Lee, J. W. AU - Sien, T. AU - Schaufele, R. AU - Bacher, J. AU - Switchenko, A. C. AU - Goodman, T. C. AU - Pizzo, P. A. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1994/// VL - 32 IS - 3 SP - 205 EP - 215 SN - 0268-1218 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethseda, MD 20892, USA. N1 - Accession Number: 19941201049. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1397-89-3, 2152-56-9, 86386-73-4, 2022-85-7, 79404-91-4. Subject Subsets: Medical & Veterinary Mycology N2 - Serum levels of D-arabinitol were measured by rapid automated enzymatic assay in rabbits with experimental disseminated candidosis. The enzymatic reaction steps were performed on a standard automated clinical chemistry analyser. As a correction for renal impairment, data were expressed as serum D-arabinitol/creatinine ratio (DA/Cr). Serum creatinine concn were determined from the same sample with the same instrument, thus allowing rapid determination of the DA/Cr within one laboratory. The DA/Cr was determined in 321 samples from 132 rabbits. The mean serum DA/Cr in 31 normal non-infected rabbits was 1.51±0.2 µM/mg per dl. Among 84 rabbits with disseminated candidosis and pre-terminal samples, there was a direct correlation between DA/Cr and tissue concn of C. albicans (r=0.80; P<0.001). A threshold of elevated DA/Cr (≥3.0 µM/mg per dl) was evident in rabbits with a tissue concn of C. albicans≥3 × 104 colony forming units (CFU)/g. Elevated DA/Cr was detected in 48 (89%) of 54 rabbits at a C. albicans tissue concn of ≥3 × 104 CFU/g vs. 1 (3%) of 30 rabbits with <3 × 104 CFU/g (P<0.0001). Among all 101 rabbits with disseminated candidosis, an elevated DA/Cr was detected at any point during infection in 60 (92%) of 65 rabbits having a C. albicans tissue concn ≥3 × 104 CFU/g vs. 13 (36%) of 36 rabbits with <3 × 104 CFU/g (P<0.0001). The relationship between the tissue response to antifungal therapy (amphotericin B, flucytosine, fluconazole, SCH 39304 or cilofungin) and change in DA/Cr was further analysed. Ten (91%) of 11 rabbits with a tissue-proven response to antifungal therapy (defined as ≥10²-fold reduction of CFU/g in comparison to untreated controls) had a >50% reduction in elevated DA/Cr levels. By comparison, 10 (83%) of 12 treated rabbits with no response to therapy had persistently elevated DA/Cr levels (P<0.001). It is concluded that these findings further indicate that serial DA/Cr measurements may be useful for diagnosis and therapeutic monitoring of disseminated candidosis. KW - amphotericin B KW - arabinitol KW - candidosis KW - cilofungin KW - diagnosis KW - drug therapy KW - experimental infections KW - fluconazole KW - flucytosine KW - generalized infections KW - infections KW - serum KW - therapy KW - Candida albicans KW - mice KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 5-fluorocytosine KW - candidiasis KW - chemotherapy KW - fungus KW - Hyphomycetes KW - SCH 39304 KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201049&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of Candida casts in experimental renal candidiasis: implications for the diagnosis and pathogenesis of upper urinary tract infection. AU - Navarro, E. E. AU - Almario, J. S. AU - King, C. AU - Bacher, J. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1994/// VL - 32 IS - 6 SP - 415 EP - 426 SN - 0268-1218 AD - Navarro, E. E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200925. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The diagnostic yield, methods for detection and pathogenesis of Candida cast formation were studied in serially collected urine specimens from immunologically intact and granulocytopenic rabbit models of haematogenous disseminated C. albicans infection. Refractile blastoconidia and pseudohyphae of Candida encased in the granular matrix were seen on wet mounts while Candida stained a brilliant red in the fuchsia pink tubular matrix on periodic acid-Schiff (PAS) stained cytopathology filters. Among 24 rabbits with disseminated candidosis, 11 (46%) had Candida casts detectable by wet mount and PAS stained urine filters in comparison to none of 10 non-infected immunologically normal controls (P=0.014). 15 (70%) of 21 episodes of Candida casts were detected within the first 3 d of infection, indicating possible utility in the early diagnosis of renal candidosis. No Candida casts were detected in the urine of granulocytopenic rabbits, possibly due to the rapid destruction of tubules and abrogation of cast formation. This absence of detectable Candida in 8 infected granulocytopenic rabbits differed significantly from that of 24 non-granulocytopenic infected rabbits, in which Candida casts were detected in 11 (46%) (P=0.029). Candida cast formation occurred predominantly in the cortex. Histopathological examination demonstrated invasion of Candida into the glomerular tufts and peritubular capillaries, followed by development of Candida casts in the proximal and distal tubules, respectively. It is concluded that detection of renal Candida casts may be a useful diagnostic marker in distinguishing upper versus lower urinary tract candidosis. KW - candidosis KW - detection KW - diagnosis KW - experimental infections KW - generalized infections KW - immunocompromised hosts KW - infections KW - kidneys KW - pathogenesis KW - techniques KW - urinary tract KW - urine KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - candidiasis KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200925&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development and evaluation of a rapid and simple procedure for detection of Pneumocystis carinii by PCR. AU - Cartwright, C. P. AU - Nelson, N. A. AU - Gill, V. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1994/// VL - 32 IS - 7 SP - 1634 EP - 1638 SN - 0095-1137 AD - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951201897. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology; Public Health N2 - A simplified PCR-based assay for the detection of P. carinii DNA in clinical specimens was developed. The adoption of a rapid DNA extraction procedure and the introduction of a type of ELISA for PCR product detection enabled this procedure to be carried out in a single working day in a clinical microbiology laboratory. The PCR assay was prospectively compared with an immunofluorescent-antibody (FA) staining method for the detection of P. carinii in induced sputum and bronchoalveolar lavage (BAL) specimens. Results showed that, for induced sputum specimens, FA staining had a sensitivity of 78% (32 of 41 specimens) and a specificity of 100% (166 of 166); PCR was 100% sensitive (41 of 41) and 98% specific (162 of 166). For BAL specimens, FA staining was 100% sensitive (21 of 21 specimens) and 100% specific (133 of 133), and PCR had a sensitivity of 100% (21 of 21) and a specificity of 99% (132 of 133). It is suggested that use of the PCR-based assay could effect clinically useful improvements in the sensitivity of induced sputum specimens for the detection of P. carinii. KW - detection KW - diagnosis KW - human diseases KW - infections KW - lungs KW - mycoses KW - parasites KW - pneumocystis carinii pneumonia KW - pneumocystosis KW - pneumonia KW - polymerase chain reaction KW - sputum KW - techniques KW - fungi KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - fungus KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201897&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice. AU - Chan, P. C. AU - Mahler, J. AU - Bucher, J. R. AU - Travlos, G. S. AU - Reid, J. B. JO - Toxicon (Oxford) JF - Toxicon (Oxford) Y1 - 1994/// VL - 32 IS - 8 SP - 891 EP - 908 SN - 0041-0101 AD - Chan, P. C.: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19950304253. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9007-49-2. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Riddelliine, a pyrrolizidine alkaloid isolated from Senecio riddellii (collected from rangeland in USA), is implicated in the poisoning of livestock, and is known to contaminate human food sources. Riddelliine was administered to rats and mice (p.o.) for 13 weeks. Body weight gains were inversely proportional to riddelliine dose, and treated animals exhibited liver damage; adenomas were observed in some rats. In separate studies, riddelliine (150 mg/kg) stimulated the frequency of micronucleated erythrocytes in the peripheral blood of male mice, and riddelliine (25 mg/kg) increased unscheduled DNA synthesis in primary hepatocytes of rats and mice. KW - adenoma KW - biosynthesis KW - carcinogens KW - DNA KW - liver KW - neoplasms KW - plant composition KW - poisonous plants KW - pyrrolizidine alkaloids KW - toxic substances KW - toxicology KW - USA KW - animals KW - Asteraceae KW - mice KW - plants KW - rats KW - Senecio riddellii KW - eukaryotes KW - Asterales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Senecio KW - Asteraceae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - chemical constituents of plants KW - deoxyribonucleic acid KW - poisons KW - toxic plants KW - United States of America KW - Plant Composition (FF040) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Weeds and Noxious Plants (FF500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950304253&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transfusion of blood components to persons infected with human immunodeficiency virus type 1: relationship to opportunistic infection. AU - Sloand, E. AU - Kumar, P. AU - Klein, H. G. AU - Merritt, S. AU - Sacher, R. JO - Transfusion JF - Transfusion Y1 - 1994/// VL - 34 IS - 1 SP - 48 EP - 53 SN - 0041-1132 AD - Sloand, E.: National Heart, Lung and Blood Institute, National Institutes of Medicine, Bethesda, MD, USA. N1 - Accession Number: 19941200802. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - The records of 196 HIV-1-infected patients in the USA with CD4 lymphocyte counts <250 cells/mm³ were reviewed to determine if there were more opportunistic infections in subjects who previously received transfusions than in those who had not received transfusions. The decline in CD4 cells was also compared and the frequency of transfusion reactions and red cell alloantibodies was assessed. The frequency of cytomegalovirus (CMV), wasting and bacterial infections (P<0.01), but not of Pneumocystis carinii pneumonia (PCP) (P<0.2), was significantly increased in patients who had previously received transfusions. This effect was independent of CD4 count, race or risk factor. The frequency of CMV infection, but not of PCP, was also related to the number of units of blood received (P<0.01). Significant bacterial infections occurred primarily in persons with CMV infection, of whom there were more in the transfusion cohort. When analysed separately in the group of patients without CMV infection, the frequency of bacterial infection was unrelated to transfusion. Other opportunistic infections were less common but included Candida, Cryptococcus neoformans, Toxoplasma, Cryptosporidium and Mycobacterium avium-intracellulare infections as well as miliary tuberculosis. The death rate in those who received transfusions was greater than that in patients who had never received a transfusion. None of the 130 patients who received red cell transfusions developed red cell alloantibodies. It is concluded that there is a relationship between transfusion and virus activation in AIDS patients and the potential benefits of modifying the preparation of blood components should be investigated. KW - acquired immune deficiency syndrome KW - Bacterial diseases KW - Blood products KW - blood transfusion KW - candidosis KW - cryptococcosis KW - cryptosporidiosis KW - HIV infections KW - human immunodeficiency viruses KW - immunocompromised hosts KW - lungs KW - Mortality KW - opportunistic infections KW - parasites KW - Pneumocystis carinii pneumonia KW - pneumocystosis KW - pneumonia KW - predisposition KW - toxoplasmosis KW - USA KW - Candida KW - Cryptococcus neoformans KW - Cryptosporidium KW - Cytomegalovirus KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - Toxoplasma KW - Toxoplasma gondii KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Cryptosporidiidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Sarcocystidae KW - Toxoplasma KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterial infections KW - bacterioses KW - bacterium KW - candidiasis KW - death rate KW - european blastomycosis KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200802&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ivermectin in human medicine. AU - Ottesen, E. A. AU - Campbell, W. C. JO - Journal of Antimicrobial Chemotherapy JF - Journal of Antimicrobial Chemotherapy Y1 - 1994/// VL - 34 IS - 2 SP - 195 EP - 203 SN - 0305-7453 AD - Ottesen, E. A.: Clinical Parasitology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950810233. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 70288-86-7. Subject Subsets: Helminthology N2 - Current concepts about the pharmacokinetics and biochemical mode of action of ivermectin are reviewed as is clinical evidence which may suggest additional uses in human medicine, under the headings: pharmacology and mode of action; clinical studies; filarial infections other than onchocerciasis (Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans, M. ozzardi); gastrointestinal parasites (Ascaris lumbricoides, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, hookworm, cutaneous larva migrans, ectoparasites). KW - anthelmintics KW - drug therapy KW - ectoparasites KW - filariids KW - helminths KW - hookworms KW - human diseases KW - ivermectin KW - larva migrans KW - mode of action KW - onchocerciasis KW - parasites KW - pharmacokinetics KW - pharmacology KW - reviews KW - Ascaris lumbricoides KW - Brugia malayi KW - Enoplida KW - Enterobius vermicularis KW - Loa loa KW - man KW - Mansonella ozzardi KW - Mansonella perstans KW - Rhabditida KW - Strongyloides stercoralis KW - Trichuris trichiura KW - Wuchereria bancrofti KW - Ascaris KW - Ascarididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Brugia KW - Onchocercidae KW - Enterobius KW - Oxyuridae KW - Loa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Mansonella KW - Strongyloides KW - Strongyloididae KW - Trichuris KW - Trichuridae KW - Trichinellida KW - Dorylaimia KW - Enoplea KW - Wuchereria KW - Enoplia KW - Adenophorea KW - African eyeworm KW - Ascaridida KW - chemotherapy KW - creeping eruption KW - nematodes KW - onchocercosis KW - parasitic worms KW - pinworm KW - river blindness KW - Secernentea KW - Spirurida KW - threadworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950810233&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of amphotericin B and fluconazole on platelet membrane glycoproteins. AU - Sloand, E. M. AU - Kumar, P. AU - Yu, M. AU - Klein, H. G. JO - Transfusion JF - Transfusion Y1 - 1994/// VL - 34 IS - 5 SP - 415 EP - 420 SN - 0041-1132 AD - Sloand, E. M.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201883. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of amphotericin B and fluconazole on platelet membrane glycoproteins (GP) were examined by incubation of split aliquots of fresh and stored platelet concentrates (PCs) in storage bags with these drugs for 3 d. To determine the effect of storage, PCs were stored for 5 d and aliquots removed on days 1-5 were placed in platelet storage bags with 4 µg/ml amphotericin B for 2-6 h. Membrane glycoprotein expression was assessed by flow cytometry with fluorescein isothiocyanate-labelled monoclonal antibodies (MoAbs) directed against the following antigens: GPIb (CD42b), CD63 (an activation protein), P-selectin (CD62) and GPIIb/IIIa (CD41a). Amphotericin B produced a concn-dependent decrease in the surface binding of CD42b MoAb with no consistent changes in the binding of CD41a, CD63 or CD62 MoAbs after a 3-d exposure. Stored but not fresh PCs showed decreased binding of MoAb CD42b after a 6-h exposure to amphotericin B (4 µg/ml). Fluconazole produced no changes. When the binding of MoAb CD42b to permeabilized platelets was used to measure total platelet content, amphotericin B (4 µg/ml) decreased MoAb CD42b binding to a similar degree in fresh and stored platelets. Inhibition of aggregation to ADP and collagen and ADP and epinephrine was seen in stored but not fresh PCs. Therapeutic levels of amphotericin B resulted in partial loss of total platelet GPIb in fresh and stored PCs, but decreased surface expression on platelet membrane GPIb only in stored platelets. It is suggested that this difference between fresh and stored platelets may be related to the limited reservoir of GPIb available for redistribution to the membrane in the previously stored PCs and may account for the decreased recovery of transfused platelets observed in some patients receiving amphotericin B. KW - amphotericin B KW - antifungal agents KW - drug toxicity KW - platelets KW - toxicity KW - blood platelets KW - fungistats KW - thrombocytes KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201883&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit. AU - Robins, E. D. AU - Nelson, L. M. AU - Hoeg, J. M. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1994/// VL - 35 IS - 1 SP - 52 EP - 59 SN - 0022-2275 AD - Robins, E. D.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20852, USA. N1 - Accession Number: 19941412845. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 57-83-0. Subject Subsets: Human Nutrition N2 - WHHL and NZW rabbits were compared with regard to oocyte morphology and fertilization rates after stimulation with equine chorionic gonadotropin. Hypothalamic-pituitary-ovarian axis function was also examined by measuring baseline and gonadotropin releasing hormone-stimulated plasma oestradiol, progesterone and gonadotropin concentrations, before and after simvastatin inhibition of de novo cholesterol synthesis. WHHL rabbit oocytes remained encased in cumulus and had a lowered fertilization rate (9/50 vs. 83/87, P<0.05). WHHL rabbits had lower baseline oestradiol concentrations (7.1±0.72 vs. 10.2±0.94, P<0.05) and had higher baseline follicle stimulating hormone (P<0.05) and luteinizing hormone (P<0.05) concentrations. Simvastatin lowered luteal progesterone concentrations only in WHHL rabbits (P<0.05). It is concluded that the hypothalamic-pituitary-ovarian axis in WHHL rabbits is abnormal. The reduced availability of intracellular cholesterol for progesterone synthesis by inhibition of de novo cholesterol synthesis leads to a significant reduction in plasma progesterone concentrations in the WHHL. The findings have implications for women with familial hypercholesterolaemia, particularly regarding treatment with inhibitors of de novo cholesterol synthesis. KW - female animals KW - gonadotropins KW - hypercholesterolaemia KW - hyperlipaemia KW - oestrogens KW - oocytes KW - progesterone KW - sex hormones KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - estrogens KW - hypercholesterinemia KW - hypercholesterolemia KW - hyperlipemia KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412845&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits. AU - Chao, F. F. AU - Blanchette-Mackie, E. J. AU - Dickens, B. F. AU - Gamble, W. AU - Kruth, H. S. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1994/// VL - 35 IS - 1 SP - 71 EP - 83 SN - 0022-2275 AD - Chao, F. F.: Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941412846. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Early developing atherosclerotic lesions were examined to assess when unesterified cholesterol-rich lipid particles (UCLP) appear and when they become enriched in cholesterol and sphingomyelin. Cholesterol-fed NZW rabbits, which rapidly develop atherosclerotic lesions, and genetically hyperlipaemic WHHL rabbits, which develop lesions over a longer period of time, were studied. UCLP of peak density (d) 1.04 g/ml appear as early as 4 weeks after the onset of cholesterol feeding and progressively accumulate during atherosclerotic lesion development. Beginning with their appearance and afterwards, UCLP contain a saturating level (2:1 molar ratio) of cholesterol relative to phospholipid. Whereas, early UCLP are enriched in phosphatidylcholine, with time UCLP become enriched with sphingomyelin. Another UCLP population having a peak density of 1.09 g/ml was present in control aortas and increased in amount more slowly than the d 1.04 g/ml UCLP during cholesterol feeding. The d 1.09 g/ml particles were predominantly unilamellar vesicles, the majority between 100 and 200 nm in diameter. They contained >90% of their cholesterol in unesterified form and their ratio of unesterified cholesterol to phospholipid progressively increased from 0.6 to 1.7 during cholesterol feeding. Liposome resistance to solubilization by high density lipoproteins is known to be increased by enrichment with unesterified cholesterol and sphingomyelin. Sphingomyelin enrichment of UCLP could stabilize cholesterol in a form that does not readily crystallize. However, at the same time, the early and progressive accumulation of UCLP in developing atherosclerotic lesions may limit reverse cholesterol transport and accelerate disease progression. KW - atherosclerosis KW - cardiovascular diseases KW - cholesterol KW - intake KW - lipoproteins KW - liposomes KW - phospholipids KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412846&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel missense mutation in the C-terminal domain of lipoprotein lipase (Glu410->Val) leads to enzyme inactivation and familial chylomicronemia. AU - Previato, L. AU - Guardamagna, O. AU - Dugi, K. A. AU - Ronan, R. AU - Talley, G. D. AU - Santamarina-Fojo, S. AU - Brewer, H. B., Jr. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1994/// VL - 35 IS - 9 SP - 1552 EP - 1560 SN - 0022-2275 AD - Previato, L.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N115, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19941412836. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9004-02-8. Subject Subsets: Human Nutrition KW - hyperchylomicronaemia KW - lipoprotein lipase KW - mutations KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diacylglycerol lipase KW - hyperchylomicronemia KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412836&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism. AU - Ikewaki, K. AU - Rader, D. J. AU - Zech, L. A. AU - Brewer, H. B., Jr. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1994/// VL - 35 IS - 10 SP - 1809 EP - 1819 SN - 0022-2275 AD - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951400828. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Human Nutrition N2 - A study was conducted to: elucidate the metabolic basis of the low apoprotein (apo)A-I values in abetalipoproteinaemia (ABL); examine whether in vivo apoE production rates are normal in the absence of apoB-lipoprotein secretion; and to test the hypothesis that apoE influences apoA-I and HDL catabolism in ABL. 131I-labelled apoA-I and 125I-labelled apoE were reassociated with autologous lipoproteins and injected into 2 unrelated ABL patients and control subjects. The mean residence time of apoA-I in ABL (2.4 days) was significantly decreased by nearly 50% compared with control subjects (4.7±0.6 days). ApoA-I production rates were also significantly decreased by 40% in ABL (7.1) compared with control subjects (11.8±1.7 mg kg-1 day-1). The mean residence time of apoE in ABL (0.50 days) was somewhat shorter than that of control subjects (0.66 ± 0.15 days), whereas the mean apoE production rate in ABL (2.14) was not substantially different from that of control subjects (1.55±0.62 mg kg-1 day-1). HDL subfractions LpA-I and LpA-I:A-II were isolated using immunoaffinity chromatography. In contrast to the normal metabolism, apoA-I in LpA-I:A-II particles was catabolized at a faster rate than apoA-I in LpA-I, accounting for the greater decrease of plasma LpA-I:A-II relative to LpA-I in the ABL patients. HDL subfractions without and with apoE were also isolated using anti-apoE immunoaffinity chromatography. Labelled apoA-I in apoE-containing HDL was catabolized faster than that in HDL without apoE. Among the 3 different forms of apoE, the apoE monomer was catabolized at the fastest rate, the apoE homodimer at an intermediate rate and the apoE-A-II heterodimer had the slowest rate of catabolism. It is concluded that decreased apoA-I values in ABL are due to a decreased rate of apoA-I production as well as an increased rate of apoA-I catabolism, in particular that of apoA-I in LpA-I:A-II. Despite the lack of secretion of apoB-containing lipoproteins, apoE production is not impaired in ABL. These results provide insight into the role of apoB and apoE in HDL metabolism. KW - abetalipoproteinaemia KW - apolipoproteins KW - high density lipoprotein KW - lipid metabolism KW - metabolism KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - abetalipoproteinemia KW - fat metabolism KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400828&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope kinetic study. AU - Vergès, B. AU - Rader, D. AU - Schaefer, J. AU - Zech, L. AU - Kindt, M. AU - Fairwell, T. AU - Gambert, P. AU - Brewer, H. B., Jr. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1994/// VL - 35 IS - 12 SP - 2280 EP - 2291 SN - 0022-2275 AD - Vergès, B.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19951405196. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition KW - apolipoproteins KW - high density lipoprotein KW - hypertriglyceridaemia KW - low density lipoprotein KW - metabolism KW - very high density lipoprotein KW - very low density lipoprotein KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hypertriglyceridemia KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405196&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupational risks for colon cancer in Sweden. AU - Chow, W. H. AU - Malker, H. S. R. AU - Hsing, A. W. AU - McLaughlin, J. K. AU - Weiner, J. A. AU - Stone, B. J. AU - Ericsson, J. L. E. AU - Blot, W. J. JO - Journal of Occupational Medicine JF - Journal of Occupational Medicine Y1 - 1994/// VL - 36 IS - 6 SP - 647 EP - 651 SN - 0096-1736 AD - Chow, W. H.: National Cancer Institute, Division of Cancer Etiology, Epidemiology and Biostatistics Program, Bethesda, Maryland, USA. N1 - Accession Number: 19952005675. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health N2 - Using the Cancer-Environment Registry of Sweden, which links census information (1960) with cancer incidence data (1961 to 1979), the authors conducted a systematic, population-based assessment of colon cancer incidence among cohorts defined by industry and occupation for all employed persons in Sweden. Small but statistically significant excesses of colon cancer were observed among white-collar occupations, including administrators, professionals, and clerical and sales workers, whereas a reduction in incidence was found among workers in agricultural and related jobs, such as farmers, fishermen and hunters. Analysis by subsite within the colon revealed little difference in results. The observed risk patterns are consistent with previous reports on colon cancer risk and occupational physical activity levels, ie, elevated risk among sedentary white-collar workers and reduced risk among agricultural workers. Few craftsman and production processing jobs were linked to colon cancer, although statistically significant excesses were observed among shoe and leather workers, metal smiths, and foundry workers in the metal manufacturing industry. The findings indicate that occupation in general is likely to play a relatively small role in colon cancer aetiology with perhaps its major contribution an indirect one via physical activity. KW - colon KW - colon cancer KW - human diseases KW - neoplasms KW - occupational hazards KW - occupational health KW - occupations KW - Europe KW - Sweden KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancer sites KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005675&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupational cancer mortality among women employed in the telephone industry. AU - Dosemeci, M. AU - Blair, A. JO - Journal of Occupational Medicine JF - Journal of Occupational Medicine Y1 - 1994/// VL - 36 IS - 11 SP - 1204 EP - 1209 SN - 0096-1736 AD - Dosemeci, M.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952004235. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Public Health N2 - A mortality odds ratio (MOR) analysis among women employed in the telephone industry was conducted using death certificates from 24 reporting states of the USA for 1984 through 1989. Usual occupation and industry from the death certificates were coded using the 1980 Bureau of the Census occupational and industrial classification system. There were 2444 cancer deaths among women in the telephone industry (code 441). Among younger (age <49) white women, significant excess risks were observed from cancers of the rectum (MOR = 3.3; 95% confidence interval [CI] = 1.2 to 8.7), connective tissue (MOR = 4.4; 95% CI = 2.2 to 8.8), breast (MOR = 1.6; 95% CI = 1.3 to 2.1), corpus uteri (MOR = 3.3; 95% CI 1.5 to 7.5), ovary (MOR = 2.1; 95% CI = 1.3 to 3.5), and brain (MOR = 2.1; 95% CI = 1.2 to 3.7). Cancer of the connective tissue showed an almost sixfold risk (MOR = 5.5; 95% CI = 2.0 to 14.8) for the age group of 30 to 39 years. Excess risk of cancer of the connective tissue were observed among engineers and technicians, office workers, telephone operators, and mechanics and repairers (MOR = 8.5, 4.9, 1.7, and 4.4, respectively), suggesting a possible relationship with modern technological exposures in the telephone industry. Risks for cancers of the breast, corpus uteri, ovary, and brain were also elevated among these jobs. The authors did not have information on other risk factors for these cancer sites; therefore, socioeconomic status or lifestyle may explain these observed associations, particularly for the cancers of the reproductive system. Possible exposure to new instruments, machinery, or production procedures introduced in the modern telephone industry also may account for excess risks observed, particularly among younger women. KW - human diseases KW - neoplasms KW - occupational hazards KW - occupations KW - telephones KW - women KW - workers KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - United States of America KW - Occupational Health and Safety (VV900) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk of multiple myeloma by occupation and industry among men and women: a 24-state death certificate study. AU - Figgs, L. W. AU - Dosemeci, M. AU - Blair, A. JO - Journal of Occupational Medicine JF - Journal of Occupational Medicine Y1 - 1994/// VL - 36 IS - 11 SP - 1210 EP - 1221 SN - 0096-1736 AD - Figgs, L. W.: Occupational Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19952004236. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Public Health N2 - This cancer surveillance investigation used death certificates from 24 USA states for the period 1984-1989 to identify multiple myeloma and occupation associations and to stimulate hypotheses. A case-control study of multiple myeloma was created from 3 159 417 certificates in which 12 148 male and female cases were frequency matched by age, race, and gender with five controls per case. The authors screened 231 industries and 509 occupations. Women demonstrated significant excess risk among managers and administrators, post-secondary teachers, elementary teachers, social workers, other sales workers, waitresses, and hospital maids. Men showed significant risks among computer system scientists, veterinarians, elementary teachers, authors, engineering technicians, general office supervisors, insurance adjusters, barbers, electronic repairers, supervisors of extracting industries, production supervisors, photoengravers, and grader/dozer operators. Male and female elementary school teachers demonstrated the most consistent, statistically significant increased risk of multiple myeloma. KW - human diseases KW - myeloma KW - occupational hazards KW - occupations KW - risk assessment KW - workers KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - United States of America KW - Occupational Health and Safety (VV900) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004236&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality from gastric cardia and lower esophagus cancer and occupation. AU - Ward, M. H. AU - Dosemeci, M. AU - Cocco, P. JO - Journal of Occupational Medicine JF - Journal of Occupational Medicine Y1 - 1994/// VL - 36 IS - 11 SP - 1222 EP - 1227 SN - 0096-1736 AD - Ward, M. H.: Occupational Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA. N1 - Accession Number: 19952004237. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health N2 - The incidence of adenocarcinoma of the gastric cardia and oesophagus is increasing steadily in the USA. Little is known about the aetiology of these cancers. The authors used occupation and industry information on the death certificates from 24 states (1984 to 1989) to conduct a case-control analysis of gastric cardia and gastric cardia/lower oesophagus cancer. Risks were also calculated for other gastric cancers combined. Controls were deaths from other causes except cancer and gastrointestinal disorders. Increased risks of gastric cardia and cardia/lower oesophagus among white women were found for administrative jobs (cardia odds ratio (OR) = 3.9; 95% confidence interval (CI), 1.5-9.8) and health professionals (cardia OR = 1.8; 95% CI, 0.6-5.3). Occupations associated with a lower socioeconomic status showed no significant excess risks. A similar pattern in risks was seen for men. KW - human diseases KW - mortality KW - neoplasms KW - occupational hazards KW - occupational health KW - occupations KW - stomach KW - workers KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - death rate KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004237&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dose-dependent antifungal activity and nephrotoxicity of amphotericin B colloidal dispersion in experimental pulmonary aspergillosis. AU - Allende, M. C. AU - Lee, J. W. AU - Francis, P. AU - Garrett, K. AU - Dollenberg, H. AU - Berenguer, J. AU - Lyman, C. A. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 3 SP - 518 EP - 522 SN - 0066-4804 AD - Allende, M. C.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200980. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The safety and efficacy of amphotericin B colloidal dispersion (ABCD) for the treatment of invasive pulmonary aspergillosis in persistently granulocytopenic rabbits were investigated. Treatment groups included ABCD in dosages of 1, 5 and 10 mg/kg daily intravenously or conventional desoxycholate amphotericin B (DAmB) at 1 mg/kg daily intravenously. Antifungal activity was directly related to increasing dosage of ABCD as determined by the concn of Aspergillus fumigatus organisms in lungs and the frequency of haemorrhagic pulmonary lesions. At 5 and 10 mg/kg daily, there was a significant reduction in the tissue burden of A. fumigatus as measured by percent culture-positive lobes and colony forming units (CFU)/gram of tissue (P≤0.001), whereas at 1 mg/kg daily the tissue burden of A. fumigatus was not significantly different from that in untreated controls. Microbiological clearance was significantly greater at 1 mg/kg of DAmB daily than at 1 mg/kg of ABCD daily (P≤0.001). There was no difference in microbiological clearance of bronchoalveolar lavage fluid among the treatment groups as measured by CFU/ml. As determined by survival, ABCD at 5.0 mg/kg daily was more effective than DAmB at 1.0 mg/kg daily and ABCD at 10 mg/kg daily. ABCD at 10 mg/kg daily was more nephrotoxic than the lower dosages of ABCD and resulted in higher mortality. Impairment of glomerular filtration developed as a direct function increasing the ABCD dosage (r=0.77, P<0.001). It is concluded that this study found dose-dependent antifungal activity and nephrotoxicity of ABCD against invasive pulmonary aspergillosis in persistently granulocytopenic rabbits and showed that the optimal dosage of ABCD for antifungal activity and safety was 5 mg/kg. KW - administration KW - amphotericin B KW - aspergillosis KW - drug formulations KW - drug therapy KW - drug toxicity KW - experimental infections KW - infections KW - kidneys KW - lipids KW - lungs KW - therapy KW - toxicity KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - chemotherapy KW - fungus KW - Hyphomycetes KW - lipins KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200980&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacokinetics and safety of a unilamellar liposomal formulation of amphotericin B (AmBisome) in rabbits. AU - Lee, J. W. AU - Amantea, M. A. AU - Francis, P. A. AU - Navarro, E. E. AU - Bacher, J. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 4 SP - 713 EP - 718 SN - 0066-4804 AD - Lee, J. W.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200863. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - A unilamellar liposomal formulation of amphotericin B (LAmB, AmBisome) was safely administered intravenously to 20 rabbits at 0.5, 1.0, 2.5, 5 or 10 mg/kg of body wt, whereas of 12 rabbits given desoxycholate amphotericin B (DAmB) intravenously at 0.5, 1.0 or 1.5 mg/kg, 2 died of acute cardiac toxicity when DAmB was administered at the highest dose. Single-dose LAmB (1 mg/kg) achieved a max. concn in serum (Cmax) of 26±2.4 µg/ml and an area under the curve to infinity (AUC0-∞) of 60±16 µg.h/ml, while single-dose DAmB (1.0 mg/kg), by comparison, achieved a lower Cmax (4.7±0.2 µg/ml; P=0.001) and a lower AUC0-∞ (30.6±2.2 µg.h/ml; P=0.07). following administration of a single dose of LAmB (10 mg/kg), a disproportionately higher Cmax (287±14 µg/ml) and AUC0-∞ (2223±246 µg.h/ml) occurred, indicating saturable elimination. After chronic dosing (n=4) with LAmB at 5.0 mg/kg daily for 28 d or DAmB at 1.0 mg/kg daily for 28 d, LAmB achieved daily peak levels of 122.8±5.8 µg/ml and trough levels of 34.9±1.8 µg/ml, while DAmB reached a peak of only 1.76±0.11 µg/ml and trough levels of 0.46±0.04 µg/ml (P≤0.001). Significant accumulations of amphotericin B into reticuloendothelial organs were observed, with 239±39 µg/g found in the liver after chronic LAmB dosing (5 mg/kg daily), which was 7-fold higher than the 33±6 µg/g after DAmB dosing (1 mg/kg daily). Accumulation in kidneys, however, remained 14-fold lower (P=0.04) following LAmB dosing (0.87±0.61 µg/g) than after DAmB dosing (12.7±4.6 µg/g). Nephrotoxicity occurred in only 1 of 4 LAmB-treated animals, while it occurred in all 4 chronically DAmB-treated animals; mild hepatotoxicity with transaminase elevations was seen in 1 LAmB-treated rabbit. It is concluded that LAmB safely achieves higher Cmaxs and AUC0-∞s and demonstrates saturable, non-linear elimination from plasma via reticuloendothelial organ uptake. The reduced nephrotoxicity of LAmB correlated with diminished levels of amphotericin B in the kidneys. KW - administration KW - amphotericin B KW - drug formulations KW - kidneys KW - liposomes KW - liver KW - pharmacokinetics KW - toxicity KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200863&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins. AU - Kageyama, S. AU - Anderson, B. D. AU - et al. AU - Hoesterey, B. L. ( JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 5 SP - 1107 EP - 1111 SN - 0066-4804 AD - Kageyama, S.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050080. Publication Type: Journal Article. Language: English. KW - Antiviral agents KW - binding KW - human immunodeficiency viruses KW - Inhibition KW - proteinase inhibitors KW - proteins KW - Serum KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - KNI-272 KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050080&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Itraconazole for experimental pulmonary aspergillosis: comparison with amphotericin B, interaction with cyclosporin A, and correlation between therapeutic response and itraconazole concentrations in plasma. AU - Berenguer, J. AU - Ali, N. M. AU - Allende, M. C. AU - Lee, J. AU - Garrett, K. AU - Battaglia, S. AU - Piscitelli, S. C. AU - Rinaldi, M. G. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 6 SP - 1303 EP - 1308 SN - 0066-4804 AD - Berenguer, J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200895. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 1397-89-3, 79217-60-0, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - Itraconazole and amphotericin B were compared by using a newly developed model of invasive pulmonary aspergillosis in rabbits immunosuppressed with methylprednisolone and cyclosporin A (CsA). Both itraconazole at 40 mg/kg (given orally) and amphotericin B at 1 mg/kg (given intravenously) had in vivo antifungal activity in comparison with controls. At these dosages, amphotericin B was more effective than itraconazole in reducing the tissue burden (log10 colony forming units/g) of Aspergillus fumigatus (P<0.05) and the number of pulmonary lesions (P<0.01). However, there was considerable variation in the near-peak concn of itraconazole in plasma (median, 4.15 µg/ml; range, <0.5 to 16.8 µg/ml) and a strong inverse correlation between concn of itraconazole in plasma and the tissue burden of A. fumigatus. An inhibitory sigmoid maximum-effect model predicted a significant pharmacodynamic relationship (r=0.87, P<0.001) between itraconazole concn in plasma and antifungal activity as a function of the tissue burden of A. fumigatus. This model demonstrated that levels in plasma of >6 µg/ml were associated with a significantly greater antifungal effect. Levels in plasma of <6 µg/ml were associated with a rapid decline in the antifungal effect. Itraconazole, in comparison with amphotericin B, caused a 2-fold elevation of CsA levels (P<0.01) but was less nephrotoxic (P<0.01). This study of experimental pulmonary aspergillosis demonstrated that amphotericin B at 1 mg/kg daily was more active but more nephrotoxic than itraconazole at 40 mg/kg daily, that itraconazole increased concn of CsA in plasma, and that the antifungal activity of itraconazole strongly correlated with concn in plasma in an inhibitory sigmoid maximum-effect model. It is concluded that these findings further indicate the importance of monitoring concn of itraconazole in plasma as a guide to increasing dosage, improving bioavailability and optimizing antifungal efficacy in the treatment of invasive pulmonary aspergillosis. KW - amphotericin B KW - antagonism KW - aspergillosis KW - cyclosporins KW - drug antagonism KW - drug therapy KW - experimental infections KW - infections KW - itraconazole KW - lungs KW - pharmacokinetics KW - therapy KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - chemotherapy KW - fungus KW - Hyphomycetes KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200895&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacokinetics and safety of weekly dapsone and dapsone plus pyrimethamine for prevention of pneumocystis pneumonia. AU - Falloon, J. AU - Lavelle, J. AU - Ogata-Arakaki, D. AU - Byrne, A. AU - Graziani, A. AU - Morgan, A. AU - Amantea, M. A. AU - Ownby, K. AU - Polis, M. AU - Davey, R. T. Jr AU - Kovacs, J. A. AU - Lane, H. C. AU - Masur, H. AU - MacGregor, R. R. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 7 SP - 1580 EP - 1587 SN - 0066-4804 AD - Falloon, J.: LIR, NIAID, National Institutes of Health, Building 10, Room 11C-103, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050467. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 80-08-0, 58-14-0. Subject Subsets: Medical & Veterinary Mycology; Protozoology N2 - The safety and pharmacokinetics of weekly dapsone and weekly dapsone plus pyrimethamine were examined in adult patients with HIV infection in the USA who were at risk for Pneumocystis carinii pneumonia because of a prior episode or a CD4+ T-cell count <250 cells/mm³. Groups of patients received 100, 200 and 300 mg of dapsone as a single weekly dose. The maximum tolerated dose of weekly dapsone was established as 200 mg/wk in patients receiving at least 500 mg of zidovudine concomitantly. This dose of dapsone was then found to be well tolerated when combined with pyrimethamine at 25 mg. Further patients were randomized to dapsone at 200 mg or dapsone at 200 mg plus pyrimethamine at 25 mg once weekly. 26 patients each were followed for a median of 33 wk on dapsone alone and 45 wk on the combination. Seven patients in each group withdrew because of toxicity. Five patients receiving dapsone developed documented Pneumocystis pneumonia, while 4 and 2 patients receiving dapsone plus pyrimethamine developed documented and presumptive Pneumocystis pneumonia, respectively. To evaluate the tolerability of a higher dose of pyrimethamine, 11 patients had their regimen changed to dapsone at 200 mg plus pyrimethamine at 75 mg, which was well tolerated by 10 of the patients for a median period of 11 wk. The pharmacokinetics of dapsone and pyrimethamine were examined using a population pharmacokinetic model. Decreases in the apparent volume of the peripheral compartment were observed when multiple-dose regimens of dapsone were compared with single-dose dapsone and when multiple-dose regimens of dapsone plus pyrimethamine were compared with multiple dapsone alone. It is concluded that when administered weekly, dapsone at 200 mg and dapsone at 200 mg with pyrimethamine at 25 mg are both well tolerated regimens. It is suggested that the efficacy of these regimens in preventing Pneumocystis pneumonia may be less than that of trimethoprim-sulfamethoxazole. KW - acquired immune deficiency syndrome KW - antifungal agents KW - antiprotozoal agents KW - dapsone KW - drug combinations KW - HIV infections KW - hosts KW - immunocompromised hosts KW - infections KW - lungs KW - mycoses KW - opportunistic infections KW - parasites KW - pharmacokinetics KW - Pneumocystis carinii pneumonia KW - pneumocystosis KW - pneumonia KW - prophylaxis KW - pyrimethamine KW - treatment KW - USA KW - fungi KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - protozoa KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - invertebrates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - fungistats KW - fungus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro and ex vivo effects of cyclosporin A on phagocytic host defenses against Aspergillusfumigatus. AU - Roilides, E. AU - Robinson, T. AU - Sein, T. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1994/// VL - 38 IS - 12 SP - 2883 EP - 2888 SN - 0066-4804 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951202317. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 59865-13-3. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of ciclosporin A (CsA) on phagocytic defences against A. fumigatus were studied in vitro and ex vivo. After incubation with 10-250 ng/ml of CsA at 37°C for 60 min, polymorphonuclear leukocytes (PMNs) exhibited unaltered superoxide anion (O2-) production in response to phorbol myristate acetate and N-formylmethionyl leucyl phenylalanine, whereas ≥500 ng/ml significantly suppressed it (P<0.01). Moreover, at <250 ng/ml of CsA, PMNs exhibited no change in their capacity to damage unopsonized hyphae of A. fumigatus compared with controls, whereas at ≥250 ng/ml, CsA suppressed the function (P<0.01). Although neither CsA (250 ng/ml) nor hydrocortisone (10 µg/ml) suppressed PMN O2- production in response to phorbol myristate acetate and N-formylmethionyl leucyl phenylalanine, combination of the 2 agents reduced the function compared with that at the baseline (P<0.05). Incubation of monocytes with 100 ng/ml of CsA for 1 or 2 d suppressed their anti-hyphal activity. No essential change in phagocytic activity of monocyte-derived macrophages (MDMs) against A. fumigatus conidia, tested as the percentage of phagocytosing MDMs and mean number of MDM-associated conidia, was detected after 2 or 4 d of incubation with 10-1000 ng/ml of CsA. Furthermore, in rabbits treated with CsA (up to 20 mg/kg of body wt daily intravenously for 7 d), neither O2- production and hyphal damage caused by PMNs or monocytes against hyphae nor phagocytosis of conidia by pulmonary alveolar macrophages was significantly suppressed. It is concluded that CsA within therapeutically relevant concn does not suppress antifungal activity of phagocytes except that of circulating monocytes. However, it may induce significant immunosuppression of phagocyte antifungal function at relatively high concn in vitro, especially when combined with corticosteroids. KW - ciclosporin KW - immunology KW - monocytes KW - phagocytes KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - cyclosporin KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin A in epithelial differentiation and skin caracinogenesis. AU - Luca, L. M. de AU - Darwiche, N. AU - Celli, G. AU - Kosa, K. AU - Jones, C. AU - Ross, S. AU - Chen, L. C. JO - Scandinavian Journal of Nutrition/Näringsforskning JF - Scandinavian Journal of Nutrition/Näringsforskning Y1 - 1994/// VL - 38 IS - SUP 27 SP - 45 EP - 52 SN - 1102-6480 AD - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951408214. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 32 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Relations between the role of vitamin A in epithelial differentiation and skin carcinogenesis are reviewed and discussed in an attempt to understand the steps involved in the neoplastic process and to develop clinical strategies to control neoplastic progression. KW - carcinogenesis KW - differentiation KW - epithelium KW - retinol KW - reviews KW - skin KW - vitamins KW - Sweden KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - axerophthol KW - dermis KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Vitamin A: from nuclear biology to public health KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408214&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The uptake and metabolism of cysteine by Giardia lamblia trophozoites. AU - Lujan, H. D. AU - Nash, T. E. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1994/// VL - 41 IS - 2 SP - 169 EP - 175 SN - 1066-5234 AD - Lujan, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800665. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 52-90-4. Subject Subsets: Protozoology N2 - The cysteine, cystine, methionine and sulfate uptake and cysteine metabolism of Giardia lamblia [Giardia duodenalis] were studied. The analysis of radiolabelled L-cysteine uptake indicated the presence of at least 2 different transport systems. The total cysteine uptake was non-saturable, with a capacity of 3.7 pmoles/106 cells/min/µM of cysteine, and probably represented passive diffusion. However, cysteine transport was partially inhibited by L-methionine, D-cysteine and DL-homocysteine, indicating that another system specific for SH-containing amino acids was also present. Cysteine uptake was markedly decreased in medium without serum. In contrast to cysteine, L-methionine and sulfate uptake were carried out by saturable systems with apparent Km of 71 and 72 µM, respectively, but the Vmax of sulfate uptake was 6 orders of magnitude lower than the Vmax of methionine uptake. Cystine was not incorporated into trophozoites. [35S]-labelled L-cysteine and L-methionine, but not [35S]sulfate, were incorporated into Giardia proteins, indicating that the parasite lacks the capacity to synthesize cysteine or methionine from sulfate. Neither cystathionine γ lyase nor crystathionine γ synthase activity was detected in homogenates of Giardia, suggesting that the transsulfuration pathway is not active and that there is no conversion of methionine to cysteine. The data indicate that cysteine is essential for Giardia because the parasite cannot take up cystine and cannot synthesize cysteine de novo. KW - amino acids KW - biochemistry KW - cysteine KW - in vitro KW - metabolism KW - parasites KW - uptake KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800665&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The journey of malaria sporozoites in the mosquito salivary gland. AU - Pimenta, P. F. AU - Touray, M. AU - Miller, L. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1994/// VL - 41 IS - 6 SP - 608 EP - 624 SN - 1066-5234 AD - Pimenta, P. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950805814. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The fine structure of the invasive process of Aedes aegypti salivary glands by malarial parasites is described. Plasmodium gallinaceum sporozoites start the invasion process by attaching to and crossing the basal lamina and then penetrating the host plasma membrane of the salivary cells. The penetration process appeared to involve the formation of membrane junctions. Once inside the host cells, the sporozoites were seen within vacuoles attached by their anterior end to the vacuolar membrane. Mitochondria surrounded, and were closely associated with, the invading sporozoites. After the disruption of the membrane vacuole, the parasites traversed the cytoplasm, attached to, and invaded the secretory cavity through the apical plasma membrane of the cells. Inside the secretory cavity, sporozoites were seen again inside vacuoles. Upon escaping from these vacuoles, sporozoites were positioned in parallel arrays forming large bundles attached by multi-lamellar membrane junctions. Several sporozoites were seen around and inside the secretory duct. Except for the penetration of the chitinous salivary duct, these observations have morphologically characterised the entire process of sporozoite passage through the salivary gland. KW - disease vectors KW - host parasite relationships KW - invasion KW - parasites KW - sporozoites KW - ultrastructure KW - vectors KW - Aedes aegypti KW - Apicomplexa KW - culicidae KW - diptera KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805814&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytomegalovirus/herpesvirus and carotid atherosclerosis: the ARIC study. AU - Sorlie, P. D. AU - Adam, E. AU - Melnick, S. L. AU - Folsom, A. AU - Skelton, T. AU - Chambless, L. E. AU - Barnes, R. AU - Melnick, J. L. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1994/// VL - 42 IS - 1 SP - 33 EP - 37 SN - 0146-6615 AD - Sorlie, P. D.: National Heart, Lung and Blood Institute, Federal Building, Room 3A10, Bethesda, MD 20892, USA. N1 - Accession Number: 19952006674. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Antibodies to CMV and herpes simplex virus type 1 (HSV1) and type 2 (HSV2) were determined in 340 matched case-control pairs from the Atherosclerosis Risk in Communities (ARIC) Study in the USA. Cases were defined by B-mode ultrasonography as persons with thickened carotid artery walls consistent with early atherosclerosis but without a history of cardiovascular disease. Controls were defined as persons without thickened walls or history of cardiovascular disease. The case-control odds ratio for CMV antibodies was 1.55 (P = 0.03), for HSV1 1.41 (P = 0.07), and for HSV2 0.91 (P = 0.63). When adjustment was made for potential confounders, the odds ratios were 1.36 for CMV (P = 0.24), 1.21 for HSV1 (P = 0.45), and 0.61 (P = 0.05) for HSV2. These results suggest a modest association between CMV and asymptomatic carotid wall thickening consistent with early atherosclerosis. KW - atherosclerosis KW - epidemiology KW - herpes simplex viruses KW - human diseases KW - human herpesviruses KW - infections KW - North America KW - USA KW - Human herpesvirus 5 KW - man KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - arteriosclerosis KW - herpes simplex virus KW - human cytomegalovirus KW - Human herpesvirus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006674&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serological response to rotavirus infection in newborn infants. AU - Flores, J. AU - White, L. AU - Blanco, M. AU - Perez-Schael, I. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1994/// VL - 42 IS - 1 SP - 97 EP - 102 SN - 0146-6615 AD - Flores, J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003203. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - The authors report the identification of rotavirus in stools of newborn infants at the "Hospital Materno Infantil de Caricuao" (HMIC) in Caracas, Venezuela as well as the infants' serological responses to various rotavirus strains. The serological responses of another group of rotavirus-positive neonates studied previously at the "Maternidad Concepcion Palacios" (MCP) hospital was also evaluated. Fifty-four of 266 (20%) newborns examined at HMIC shed rotavirus. The infection rate was higher among infants admitted to the nursery (75%) than in those "rooming in" with their mothers (7%) (P <0.01). Eleven of the 54 neonates (20%) had diarrhoea; seven of them experienced mild, short-lived episodes, whereas five had frequent bouts of diarrhoea or diarrhoea lasting for over 3 days; the remaining 43 infants were asymptomatic. Twenty-seven of 28 rotavirus specimens tested at HMIC had VP7 serotype 4 specificity and one belonged to VP7 serotype 1; VP4 typing performed on 24 of the viruses by RNA hybridization showed these viruses to be similar to the M37 strain, a rotavirus previously associated with asymptomatic infections in newborns at MCP. IgA seroresponses were detected in eight of 11 infants born at HMIC (73%), but most failed to develop neutralization responses to homologous or heterologous strains. Newborn infants who had shed the M37 rotavirus strain at MCP reacted similarly: 16 of 24 (67%) developed a rotavirus IgA rise, but only 29% developed a neutralization response. KW - human diseases KW - immune response KW - infections KW - neonates KW - South America KW - Venezuela KW - man KW - Reoviridae KW - rotavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dsRNA viruses KW - RNA viruses KW - viruses KW - Reoviridae KW - America KW - Andean Group KW - Developing Countries KW - Latin America KW - South America KW - Threshold Countries KW - immunity reactions KW - immunological reactions KW - newborn infants KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003203&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a human group C rotavirus in Malaysia. AU - Rasool, N. B. G. AU - Hamzah, M. AU - Jegathesan, M. AU - Wong, Y. H. AU - Qian, Y. AU - Green, K. Y. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1994/// VL - 43 IS - 3 SP - 209 EP - 211 SN - 0146-6615 AD - Rasool, N. B. G.: (K.Y. Green) Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051294. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - Stool specimens from 334 infants and young children hospitalized with diarrhoea in Kuala Lumpur, Malaysia between August and November, 1987 were analysed for the presence of rotavirus double-stranded (ds) RNA by polyacrylamide gel electrophoresis. Of the 334 specimens analysed, 32 (9.6%) were positive for rotavirus RNA. One specimen (designated G147) exhibited a ds RNA electropherotype profile characteristic of Group C rotavirus and was selected for further characterization. In Northern blot hybridization studies, the gene 5 segment of strain G147 hybridized with a cDNA probe generated from the cloned gene 5 (which encodes the VP6 inner capsid protein that is group specific) of porcine Group C rotavirus strain Cowden, confirming the classification of strain G147 in Group C. The association of Group C rotavirus with diarrhoeal illness in Malaysia is consistent with earlier studies that suggest a global distribution of this virus and supports the need for additional epidemiological studies. KW - children KW - epidemiology KW - infections KW - Asia KW - Malaysia KW - man KW - rotavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - APEC countries KW - ASEAN Countries KW - Commonwealth of Nations KW - Developing Countries KW - South East Asia KW - Asia KW - Threshold Countries KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051294&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of hepatitis B surface and core antigens and transforming growth factor-α in "oval cells" of the liver in patients with hepatocellular carcinoma. AU - Hsia, C. C. AU - Thorgeirsson, S. S. AU - Tabor, E. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1994/// VL - 43 IS - 3 SP - 216 EP - 221 SN - 0146-6615 AD - Hsia, C. C.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051296. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Recent studies have identified epithelial cell populations in human livers that are similar to the "oval cells" and "transitional cells" seen in rat livers during the early stages of chemical carcinogenesis. It has been suggested that these cells may theoretically be involved in hepatocarcinogenesis. The hepatitis B virus (HBV) is also believed to play a role in the aetiology of hepatocellular carcinoma (HCC). Therefore, a study was conducted in non-tumourous livers adjacent to HCCs obtained from 26 patients from China to determine whether HBV antigens could be identified in oval cells and transitional cells using an immunohistochemical technique. Hepatitis B surface antigen (HBsAg) was detected in the non-tumourous livers of 22/26 (85%) patients. HBsAg was detected in oval cells in 18/26 (69%), in transitional cells in 21/26 (81%), and in mature hepatocytes in 22/26 (85%), but not in bile duct or ductule cells. Transforming growth factor-α (TGF-α) was expressed in oval cells, transitional cells, and bile duct cells in 24/26 (92%) patients, and in mature hepatocytes in 25/26 (96%). Coexpression of HBsAg and TGF-α was identified in the same cells in populations of oval cells and transitional cells of selected patients. Because of the possibility that oval cells could be a source of evolving HCC, these findings suggest that expression of TGF-α associated with HBV infection of oval cells could be a mechanism of human hepatocarcinogenesis. Thus, oval cells could be a site (or one of the sites) where HBV participates in the development of HCC. KW - antigens KW - carcinoma KW - hepatitis B KW - hepatocellular carcinoma KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - antigenicity KW - immunogens KW - People's Republic of China KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051296&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Whole-body energy metabolism and skeletal muscle biochemical characteristics. AU - Zurlo, F. AU - Nemeth, P. M. AU - Choksi, R. M. AU - Sesodia, S. AU - Ravussin, E. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1994/// VL - 43 IS - 4 SP - 481 EP - 486 SN - 0026-0495 AD - Zurlo, F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th St, Room 541, Phoenix, AZ 85016, USA. N1 - Accession Number: 19951409458. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - A low metabolic rate for a given body size and a low fat compared with carbohydrate oxidation ratio are known risk factors for body weight gain, but the underlying biological mechanisms are poorly understood. 24-h energy expenditure (24EE), sleeping metabolic rate (SMR), 24-h respiratory quotient (24RQ) and forearm oxygen uptake were compared with respect to the proportion of skeletal muscle fibre types and the enzyme activities of the vastus lateralis in subjects (7 men and 7 women, 30±6 years old, 79.1±17.3 kg, 22±7% body fat). The following enzymes were chosen to represent the major energy-generating pathways: lactate dehydrogenase (LDH) and phosphofructokinase (PFK) for glycolysis; citrate synthase (CS) and β-hydroxyacl-coenzyme A dehydrogenase (β-OAC) for oxidation; and creatine kinase (CK) and adenylokinase (AK) for high-energy phosphate metabolism. Forearm resting oxygen uptake adjusted for muscle size correlated positively with the proportion of fast-twitch muscle fibres (IIa: r = 0.55, P=0.04; IIb: r = 0.51, P=0.06) and inversely with the proportion of slow oxidative fibres (I: r = -0.77, P=0.001). 24EE and SMR adjusted for differences in fat-free mass, fat mass, sex and age correlated with PFK activity (r = 0.56, P=004 and r = 0.69, P=0.007, respectively). 24RQ correlated negatively with β-OAC activity (r = -0.75, P=0.002). The findings suggest that differences in muscle biochemistry account for part of the interindividual variability in muscle oxygen uptake and whole-body energy metabolism, ie, metabolic rate and substrate oxidation. KW - adults KW - body weight KW - energy metabolism KW - enzyme activity KW - nutrition physiology KW - respiratory quotient KW - skeletal muscle KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409458&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations. AU - Yanagihara, R. JO - Advances in Virus Research JF - Advances in Virus Research Y1 - 1994/// VL - 43 SP - 147 EP - 186 SN - 0065-3527 AD - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009588. Publication Type: Journal Article. Language: English. Number of References: 12 pages of refs. KW - epidemiology KW - genotypes KW - human diseases KW - markers KW - migration KW - reviews KW - viral diseases KW - Australasia KW - Melanesia KW - Deltaretrovirus KW - human t-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Human T-cell lymphotropic virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Oceania KW - Australasia KW - Pacific Islands KW - HTLV-BLV group KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009588&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene arrangement and sequence of the 5S rRNA in Filobasidiella neoformans (Cryptococcus neoformans) as a phylogenetic indicator. AU - Kwon-Chung, K. J. AU - Chang, Y. C. JO - International Journal of Systematic Bacteriology JF - International Journal of Systematic Bacteriology Y1 - 1994/// VL - 44 IS - 2 SP - 209 EP - 213 SN - 0020-7713 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201096. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The 5S rRNA gene was cloned and its organization was determined in the 4 genes encoding rRNAs in a ribosomal DNA repeat unit of F. neoformans, the teleomorph of C. neoformans. The 5S rRNA gene contained 118 nucleotides and was located 1 kb upstream from the 18S rRNA gene within the 8.6 kb fragment of the ribosomal DNA repeat unit. The sequence of the 5S rRNA gene from F. neoformans was more similar to the sequence of the 5S rRNA gene from Tremella mesenterica than to sequences of the 5S rRNA genes from Filobasidium species. The arrangement of the rRNA genes in Filobasidiella neoformans closely resembled the arrangement of the rRNA genes in Schizophyllum commune, Agaricus bisporus and Coprinus cinereus in that the 5S rRNA-coding region not only is located within the repeat unit that encodes the other rRNAs but is also transcribed in the same direction as the other rRNA genes. KW - genes KW - genetics KW - nucleotide sequences KW - ribosomal RNA KW - Cryptococcus neoformans KW - Filobasidiella KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - DNA sequences KW - Filobasidiella neoformans KW - fungus KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201096&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Host virus interactions and the molecular regulation of HIV-1: role in the pathogenesis of HIV-associated nephropathy. AU - Rappaport, J. AU - Kopp, J. B. AU - Klotman, P. E. JO - Kidney International JF - Kidney International Y1 - 1994/// VL - 46 IS - 1 SP - 16 EP - 27 SN - 0085-2538 AD - Rappaport, J.: Building 30, Room 433, National Institute of Dental Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009594. Publication Type: Journal Article. Language: English. Number of References: 165 ref. N2 - A review. KW - host range KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - kidney diseases KW - molecular biology KW - pathogenesis KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - kidney disorders KW - nephropathy KW - renal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009594&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. AU - Ray, P. E. AU - Bruggeman, L. A. AU - Weeks, B. S. AU - Kopp, J. B. AU - Bryant, J. L. AU - Owens, J. W. AU - Notkins, A. L. AU - Klotman, P. E. JO - Kidney International JF - Kidney International Y1 - 1994/// VL - 46 IS - 3 SP - 759 EP - 772 SN - 0085-2538 AD - Ray, P. E.: Building 30, Room 433, National Institute of Dental Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952009593. Publication Type: Journal Article. Language: English. Number of References: 51 ref. N2 - HIV-associated nephropathy is characterized by extensive tubulointerstitial disease with epithelial cell injury, microcystic proliferation, and tubular regeneration with glomerulosclerosis. To explore the role of bFGF as a mediator of HIV-induced interstitial disease, the authors utilized an HIV transgenic mouse model that manifests clinical and histological features observed in patients. In transgenic mice, simultaneous renal epithelial cell proliferation and injury were detected in vivo. In areas of microcystic proliferation, immunoreactive bFGF colocalized with extracellular matrix. Kidneys from transgenic mice had increased bFGF low affinity binding sites, particularly in the renal interstitium. In vitro, transgenic renal tubular epithelial cells proliferated more rapidly and generated tubular structures spontaneously, in marked contrast to nontransgenic renal cells where these pathological features could be mimicked by exogenous bFGF. These studies suggest that renal bFGF and its receptors play an important role in the pathogenesis of HIV-associated nephropathy. KW - animal experiments KW - genetically engineered organisms KW - human diseases KW - human immunodeficiency viruses KW - kidney diseases KW - laboratory animals KW - receptors KW - transgenic animals KW - man KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - animal research KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GMOs KW - human immunodeficiency virus KW - kidney disorders KW - nephropathy KW - renal diseases KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009593&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction. AU - Wang, H. AU - Chen, M. AU - Berneman, Z. N. AU - Delgado, G. AU - Paolo, J. A. di JO - Journal of Virological Methods JF - Journal of Virological Methods Y1 - 1994/// VL - 47 IS - 3 SP - 297 EP - 305 SN - 0166-0934 AD - Wang, H.: Laboratory of Biology, Bldg 37/2A19, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952000954. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health N2 - The polymerase chain reaction (PCR) was used to detect human herpesvirus-6 (HHV-6) DNA sequences from paraffin-embedded tissue from cervical cancer patients in the USA. Two of 8 cases were positive for HHV-6 using 2 sets of HHV-6 primers. Hybridization of PCR products with specific radioisotope-labelled oligonucleotide probes confirmed the results. Furthermore, HHV-6 typing was possible by adapting restriction endonuclease digestion of PCR product. This method is useful for retrospective studies in investigating the aetiological role of HHV-6 in the development of human diseases. KW - cervical cancer KW - detection KW - human diseases KW - neoplasms KW - polymerase chain reaction KW - tissues KW - North America KW - USA KW - human herpesvirus 6 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - PCR KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Management of toxoplasmosis. AU - St Georgiev, V. JO - Drugs JF - Drugs Y1 - 1994/// VL - 48 IS - 2 SP - 179 EP - 188 SN - 0012-6667 AD - St Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4C-04, Bethesda, MD 20892, USA. N1 - Accession Number: 19950810167. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Protozoology N2 - A review of the prenatal treatment of Toxoplasma gondii infections, and the treatment of T. gondii infections in newborn infants, is presented under the following subject headings: congenital toxoplasmosis (spiramycin-based therapy, pyrimethamine and sulphonamides) ; chemoprophylaxis in newborn infants; management of toxoplasmic retinochoroiditis; acquired (non- congenital) toxoplasmosis (management of toxoplasmic encephalitis, immunocompromised hosts, maintenance/prophylactic therapy); pulmonary toxoplasmosis; toxoplasmic myocarditis. KW - antiprotozoal agents KW - children KW - drug therapy KW - human diseases KW - immunocompromised hosts KW - parasites KW - reviews KW - toxoplasmosis KW - treatment KW - man KW - protozoa KW - Toxoplasma gondii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - chemotherapy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950810167&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biology of neurocysticercosis - parasite related factors modulating host response. AU - Shankar, S. K. AU - Suryanarayana, V. AU - Vasantha, S. AU - Ravi, V. AU - Ravi Kumar JO - Medical Journal Armed Forces India JF - Medical Journal Armed Forces India Y1 - 1994/// VL - 50 IS - 2 SP - 79 EP - 88 SN - 0377-1237 AD - Shankar, S. K.: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. N1 - Accession Number: 19950809286. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Helminthology N2 - In an immunohistochemical study, three features relating to the biology of Cysticercus cellulosae [Taenia solium] were identified. In an attempt at identifying which part of the parasite was recognized by the host immune system, it was found that the surface glycoprotein is immunolabelled by cerebrospinal fluid (CSF) in patients with neurocysticercosis. This surface protein is depleted following specific anthelmintic therapy, thus accounting for a fall in anticysticercal antibody levels in the CSF. The cysticercal cyst was found to have an "ACTH-like" molecule in the body wall, and neurotransmitter and mitochondrial metabolic pathways similar to the host, which facilitate immune evasion and successful parasitization. C. cellulosae was also found to contain a "peptide" opening the blood-brain barrier at the arteriolar level when injected intravenously into mice. In patients, a similar mechanism may result in cerebral oedema, particularly after treatment with praziquantel. KW - central nervous system KW - cerebrospinal fluid KW - cysticercosis KW - helminths KW - human diseases KW - immune response KW - immunohistochemistry KW - metacestodes KW - nervous system diseases KW - parasites KW - peptides KW - man KW - Taenia solium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - CNS KW - immunity reactions KW - immunological reactions KW - neuropathy KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809286&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - DNA typing of rickettsiae in naturally infected ticks using a polymerase chain reaction/restriction fragment length polymorphism system. AU - Gage, K. L. AU - Schrumpf, M. E. AU - Karstens, R. H. AU - Burgdorfer, W. AU - Schwan, T. G. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1994/// VL - 50 IS - 2 SP - 247 EP - 260 SN - 0002-9637 AD - Gage, K. L.: Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19940503438. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology; Public Health N2 - The polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) rickettsial typing system of R.L. Regenery and others was used to rapidly identify rickettsiae in naturally infected ticks. Unlike previously described methods, these PCR assays type rickettsiae directly from tick tissues without first isolating the organisms. 226 adult Dermacentor andersoni ticks were collected in the Bitterroot Mountains of western Montana, USA, and analysed for possible rickettsial infection by haemolymph test using the Gimenez stain. 13 (5.8%) of these ticks were positive by haemolymph test and selected for further analysis using the above PCR/RFLP typing system. The PCR assays performed using the first primer set (RpCS) resulted in amplification of fragments of the predicted size from 9 of the 13 haemolymph test-positive tick samples. Only 4 of these 9 tick samples were also positive in similar PCR assays performed with a second primer set (Rr190) that is presumed to be spotted fever group specific. The RFLP analyses of material amplified from these 4 ticks indicated they were infected with Rickettsia rickettsii (1 sample) and R. rhipicephali (3 samples). The PCR/RFLP analyses of the 5 PCR-positive ticks samples that were positive only in assays performed with the RpCS primer set indicated that these ticks were infected with R. bellii. The remaining 4 of 13 haemolymph test-positive tick samples gave negative PCR results with both the RpCS and Rr190 primer sets. Infected haemocytes from these PCR-negative ticks contained organisms of distinctive bacillary morphology that appeared similar to those described previously as long forms, and it is possible that these organisms belong to a genus other than Rickettsia. Established laboratory isolates of tick-borne rickettsiae from different regions of North America were also examined to determine whether this typing system produces consistent results. Multiple isolates of R. montana (9 isolates), R. bellii (5 isolates), R. rickettsii (Hlp-like) (4 isolates), and R. canada (2 isolates) were tested and no significant variations in PCR/RFLP patterns were observed between members of the same serotypes. However, among the 5 isolates of R. rhipicephali tested, 2 slightly different RFLP patterns were noted. The results suggest that this PCR/RFLP typing scheme has wide applicability for identifying rickettsiae directly from D. andersoni or D. variabilis tick tissues. KW - biotechnology KW - classification KW - diagnostic techniques KW - disease vectors KW - DNA KW - genotypes KW - identification KW - polymerase chain reaction KW - restriction fragment length polymorphism KW - species differences KW - Montana KW - North America KW - USA KW - Acari KW - Arachnida KW - Dermacentor andersoni KW - Dermacentor variabilis KW - Haemaphysalis leporispalustris KW - Ixodidae KW - Rickettsia KW - Rickettsia bellii KW - Rickettsia canadensis KW - Rickettsia montanensis KW - Rickettsia rhipicephali KW - Rickettsia rickettsii KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dermacentor KW - Ixodidae KW - Metastigmata KW - Acari KW - Haemaphysalis KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Western States of USA KW - bacterium KW - deoxyribonucleic acid KW - DNA typing KW - PCR KW - RFLP KW - Rickettsia canada KW - Rickettsia montana KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940503438&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Natural history of Schistosoma mansoni infection in mice: egg production, egg passage in the feces, and contribution of host and parasite death to changes in worm numbers. AU - Cheever, A. W. AU - Mosimann, J. E. AU - Deb, S. AU - Cheever, E. A. AU - Duvall, R. H. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1994/// VL - 50 IS - 3 SP - 269 EP - 280 SN - 0002-9637 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940805199. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Mice, C57BL/6N (B6) and BALB/cAnN (BALB), infected with Schistosoma mansoni were examined 8-26 weeks postinfection (pi) to estimate the fecundity of the worms and the contribution of death of worms and the death of heavily infected mice to the decrease in worm numbers in chronic infections. Portal worms were recovered by perfusion and the lungs were examined for parasites shunted from the portal circulation. Animals that died were more heavily infected than those that survived. Between 8 and 12 weeks pi, this loss of worms resulted in a net decrease of approximately 19% of worm pairs in surviving BALB mice, but of only 4% in B6 mice. Loss of portal worms to the lungs after the 8th week of infection was 9-13% of portal worms in BALB mice and 3-4% in B6 mice. The estimated rates of egg production by S. mansoni decreased slightly with time in both strains of mice. At 12 and 20 weeks pi, tissue eggs per worm pair and eggs passed in the faeces per worm pair often decreased as the intensity of infection increased. The loss of worms in the murine host is not considered to be relevant to most infections in humans because of the high intensity of infection relative to body size in mice and the high frequency of severe portal obstruction in murine infections. KW - developmental stages KW - fecundity KW - helminths KW - laboratory animals KW - ova KW - parasites KW - schistosomiasis KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - growth phase KW - parasitic worms KW - schistosomiasis mansoni KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805199&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetics of egg production and egg excretion by Schistosoma mansoni and S. japonicum in mice infected with a single pair of worms. AU - Cheever, A. W. AU - Macedonia, J. G. AU - Mosimann, J. E. AU - Cheever, E. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1994/// VL - 50 IS - 3 SP - 281 EP - 295 SN - 0002-9637 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19940805200. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Individual male and female schistosomes approximately 3 weeks of age were implanted into the portal venous system of C57Bl/6 mice to produce infections with a single pair of Schistosoma mansoni or S. japonicum. Mice were killed between 7 and 54 weeks after infection. Worm fecundity was measured by counting eggs accumulating in the tissues and eggs passed in the faeces. Schistosoma mansoni worm pairs laid approximately 350 eggs per day with no change in the apparent rate of egg laying between 8 and 52 weeks after infection and approximately one third of the eggs were passed in the faeces. Schistosoma japonicum worm pairs laid approximately 2200 eggs per day initially and this decreased to 1000 eggs per day by the end of the experiment, with one-third to one-half of the eggs being passed in the faeces. There was marked variability in the fecundity of individual worm pairs, but the number of eggs passed in the faeces of individual mice correlated well with the number of eggs in the intestines at all time points in S. mansoni-infected mice and at the 7th and 10th week of S. japonicum infection. KW - developmental stages KW - fecundity KW - helminths KW - laboratory animals KW - ova KW - parasites KW - schistosomiasis KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - growth phase KW - parasitic worms KW - schistosomiasis japonica KW - schistosomiasis mansoni KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805200&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Psychiatric evaluation of human immunodeficiency virus seropositives in Armed Forces. AU - Prabhu, H. R. A. AU - Arora, P. N. AU - Valdiya, P. S. AU - Chakraborty, P. K. AU - Rajguru, B. B. JO - Medical Journal Armed Forces India JF - Medical Journal Armed Forces India Y1 - 1994/// VL - 50 IS - 4 SP - 275 EP - 278 SN - 0377-1237 AD - Prabhu, H. R. A.: National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. N1 - Accession Number: 19952004075. Publication Type: Journal Article. Language: English. Number of References: 17 ref. KW - acquired immune deficiency syndrome KW - clinical aspects KW - HIV infections KW - military personnel KW - sexual transmission KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - clinical picture KW - human immunodeficiency virus infections KW - psychiatric conditions KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004075&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Murine retroviral vector that induces long-term expression of HIV-1 envelope protein. AU - Fujita, K. AU - Maldarelli, F. AU - Purcell, D. F. J. AU - Silver, J. JO - Journal of Virological Methods JF - Journal of Virological Methods Y1 - 1994/// VL - 50 IS - 1/3 SP - 293 EP - 312 SN - 0166-0934 AD - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 338, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002346. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - envelope proteins KW - gene expression KW - Rev protein KW - vectors KW - Vpu protein KW - Human immunodeficiency virus 1 KW - Retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002346&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin A in epithelial differentiation and skin carcinogenesis. AU - Luca, L. M. de AU - Darwiche, N. AU - Celli, G. AU - Kosa, K. AU - Jones, C. AU - Ross, S. AU - Chen, L. C. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1994/// VL - 52 IS - 2 SP - s45 EP - s52 SN - 0029-6643 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951400217. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - The role of vitamin A in epithelial differentiation and skin carcinogenesis is reviewed. KW - carcinogenesis KW - cell differentiation KW - retinol KW - reviews KW - skin KW - vitamins KW - axerophthol KW - cytodifferentiation KW - dermis KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400217&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stimulation of pS2 expression by diet-derived compounds. AU - Sathyamoorthy, N. AU - Wang, T. T. Y. AU - Phang, J. M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 4 SP - 957 EP - 961 SN - 0008-5472 AD - Sathyamoorthy, N.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19951405140. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Horticultural Science; Human Nutrition; Aromatic & Medicinal Plants N2 - Epidemiological studies suggest a lowered risk of hormone-dependent cancers among vegetarians, but the basis for this association remains unclear. Vegetables and fruits contain certain compounds which can be converted to biologically active hormone-like substances, such as lignans and isoflavones, by intestinal flora. The interaction of these compounds with endogenous hormones may be a novel, diet-dependent mechanism in cancer prevention. To explore this possibility, a rapid, specific assay system was developed to screen for compounds with oestrogen-like activity in tissue culture. The oestrogen receptor-positive breast cancer cell MCF-7 was used and the expression of the oestrogen-responsive protein pS2 was monitored by Northern blots. Results indicated that the phenolic compounds daidzein, equol, nordihydroguaiaretic acid, enterolactone and kaempferol were able to elicit an oestrogen-like response, while quercetin and enterodiol were not. KW - analytical methods KW - anticarcinogenic properties KW - carcinogenesis KW - cell cultures KW - flavonoids KW - flavonols KW - isoflavonoids KW - lignans KW - medicinal plants KW - oestrogenic properties KW - pharmacology KW - phenolic compounds KW - plant oestrogens KW - plants KW - eukaryotes KW - analytical techniques KW - anti-carcinogenic properties KW - drug plants KW - estrogenic properties KW - medicinal herbs KW - officinal plants KW - phytoestrogens KW - plant estrogens KW - Techniques and Methodology (ZZ900) KW - Other Produce (QQ070) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405140&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 1α,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat. AU - Anzano, M. A. AU - Smith, J. M. AU - Uskokovic´, M. R. AU - Peer, C. W. AU - Mullen, L. T. AU - Letterio, J. J. AU - Welsh, M. C. AU - Shrader, M. W. AU - Logsdon, D. L. AU - Driver, C. L. AU - Brown, C. C. AU - Roberts, A. B. AU - Sporn, M. B. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 7 SP - 1653 EP - 1656 SN - 0008-5472 AD - Anzano, M. A.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951406207. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition N2 - The vitamin D analogue, 1α,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) was used for inhibition of mammary carcinogenesis induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. Rats were first treated with a single dose of 15 or 50 mg/kg body weight NMU and then fed Ro24-5531 (2.5 or 1.25 nmol/kg diet) for 5-7 months. Ro24-5531 significantly extended tumour latency and lessened tumour incidence as well as tumour number in rats treated with the lower dose of NMU. In rats treated with the higher dose of NMU, Ro24-5531 was fed in combination with tamoxifen; in these experiments, Ro24-5531 significantly enhanced the ability of tamoxifen to reduce total tumour burden, as well as to increase the probability that a rat would be tumour free at the end of the experiment. In vitro, Ro24-5531 was 10 to 100 times more potent than 1,25-dihydroxyvitamin D3 for inhibition of proliferation of human breast cancer cell lines as well as primary cultures of cells from 2 patients with acute myelogenous leukemia. When fed chronically, Ro24-5531 did not elevate serum calcium in the present studies. The new term, "deltanoids" is proposed for the set of molecules composed of vitamin D and its synthetic analogues, in a manner similar to the naming of "retinoids" for the corresponding set of molecules related to vitamin A. KW - analogues KW - cell cultures KW - intake KW - mammary gland neoplasms KW - vitamin D KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - mammary tumour KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406207&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of N-(4-hydroxyphenyl)retinamide supplementation on vitamin A metabolism. AU - Lewis, K. C. AU - Zech, L. A. AU - Phang, J. M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 15 SP - 4112 EP - 4117 SN - 0008-5472 AD - Lewis, K. C.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19951407332. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - The efficacy of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been demonstrated in the inhibition of cancers in a variety of tissues. Moreover, toxicity effects following administration of 4-HPR have been found to be reduced or absent when compared to other retinoids. Pharmacokinetic studies in both animals and man have focused on the metabolism of 4-HPR and its metabolites, and relatively little information has been published detailing the effects of long-term administration of 4-HPR upon normal endogenous vitamin A metabolism. Thus, this study examined the effects of long-term administration of 4-HPR upon plasma and tissue vitamin A kinetics. Male Sprague-Dawley rats were fed on a control diet sufficient in vitamin A (CON group; 1.0 retinol (ROH) equivalents/g diet) or a CON diet supplemented with 4-HPR (CON + 4HPR group; 4-HPR 1173 µg/g diet). Following i.v. injection of a physiologically radiolabelled dose of ROH, ROH tracer and tracee kinetics were monitored in plasma and tissues over a 41-day period. Kinetic parameters were estimated using the SAAM/CONSAM computer modelling programmes to carry out graphical analysis of the tracer concentration curves. Mean plasma ROH levels estimated for the CON + 4HPR group were reduced to one-third of those of the CON group. Most of the kinetic parameters calculated were found to be significantly altered by the inclusion of 4-HPR in the diet. The fraction of the plasma ROH being catabolized per day (fractional catabolic rate) was nearly twice as high in the CON + 4HPR treated group (3.61±0.49) as compared to the CON group (2.00±0.68 day-1). The amount of time that vitamin A molecules spent in the body before being lost irreversibly from the system (system residence time) was decreased by half in the CON + 4HPR group (19.20±7.13 days) versus the CON group (38.63±9.62 days). Despite the increased catabolic rates and decreased system residence times estimated for the CON + 4HPR group, the estimated vitamin A use in these rats (11.01±3.10 µg/day) was 33% less than that used by the CON group (16.31±2.47 µg/day). Results suggest that long-term administration of 4-HPR perturbs normal vitamin A metabolism in rats. KW - metabolism KW - retinoids KW - retinol KW - vitamins KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - vitamin A KW - vitamin A alcohol KW - vitamin A compounds KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407332&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen. AU - Anzano, M. A. AU - Byers, S. W. AU - Smith, J. M. AU - Peer, C. W. AU - Mullen, L. T. AU - Brown, C. C. AU - Roberts, A. B. AU - Sporn, M. B. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 17 SP - 4616 EP - 4617 SN - 0008-5472 AD - Anzano, M. A.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951407405. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - It was shown that 9-cis-retinoic acid (9cRA) is a potent inhibitor of mammary carcinogenesis induced by N-nitroso-N-methylurea in Sprague-Dawley rats. Rats were first treated with a single dose of N-nitroso-N-methylurea (50 mg/kg body weight) and then fed on non-toxic levels of 9cRA (120 or 60 mg/kg of diet). 9cRA was highly effective in reducing tumour incidence, average number of tumours per rat and average tumour burden, as well as extending tumour latency. The combination of 9cRA with low levels of tamoxifen (TAM; fed at 1.0 or 0.5 mg/kg of diet) was particularly effective; addition of 9cRA to a TAM regimen doubled the number of rats that were tumour-free at autopsy and significantly diminished tumour number and tumour burden. For suppression of carcinogenesis in vivo, 9cRA was much more potent than all-trans-retinoic acid, both as a single agent or in combination with TAM, although both retinoids had equivalent inhibitory effects on DNA synthesis in cultured human breast cancer cell lines. Both 9cRA and all-trans-retinoic acid induce the expression of the adhesion molecule, E-cadherin, in the SK-BR-3 cell line. It is suggested that clinical evaluation of the combination of 9cRA and TAM, for chemoprevention or for adjuvant therapy, should be considered. KW - carcinoma KW - drug therapy KW - mammary gland neoplasms KW - neoplasms KW - prevention KW - retinoic acid KW - vitamins KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - chemotherapy KW - mammary tumour KW - tretinoin KW - vitamin A acid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407405&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The E1A oncogene induces resistance to the effects of 1,25-dihydroxyvitamin D3 on inhibition of growth of mouse keratinocytes. AU - Park, K. AU - Bae, H. AU - Heydemann, A. AU - Roberts, A. B. AU - Dotto, G. P. AU - Sporn, M. B. AU - Kim, S. J. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 23 SP - 6087 EP - 6089 SN - 0008-5472 AD - Park, K.: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951408501. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 32222-06-3. Subject Subsets: Human Nutrition N2 - Calcitriol inhibited DNA synthesis in transformed mouse keratinocytes (Pam212) in a time- and dose-dependent manner as measured by [³H]thymidine incorporation. To investigate the mechanism through which calcitriol acts, its effects on Pam212 cells further transformed with the E1A oncogene were examined. It is shown that transformation of the cells with the E1A oncogene induced resistance to the effects of calcitriol on inhibition of growth of Pam212 cells. While calcitriol treatment increased the level of expression of vitamin D receptor mRNA 20-fold in parental cells, the E1A-transformed cells failed to express vitamin D receptor mRNA even after treatment with calcitriol. Transfection of the E1A-transformed cell line with an expression construct encoding the vitamin D receptor restored receptor expression as well as the inhibition of growth by calcitriol. These results suggest that one of the mechanisms for acquisition of calcitriol resistance induced by E1A may involve loss of vitamin D receptor inducibility by calcitriol. KW - calcitriol KW - carcinogenesis KW - cell cultures KW - oncogenes KW - vitamins KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408501&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. AU - Sinha, R. AU - Rothman, N. AU - Brown, E. D. AU - Mark, S. D. AU - Hoover, R. N. AU - Caporaso, N. E. AU - Levander, O. A. AU - Knize, M. G. AU - Lang, N. P. AU - Kadlubar, F. F. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1994/// VL - 54 IS - 23 SP - 6154 EP - 6159 SN - 0008-5472 AD - Sinha, R.: Environmental Epidemiology, Branch/Epidemiology, National Cancer Institute, N1H, Rockville, Maryland 20892, USA. N1 - Accession Number: 19951408504. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition N2 - Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) activities were examined in healthy nonsmokers (33 men and 33 women). The study was designed to minimize the influence of known inducers of CYP1A2. Subjects consumed meat pan-fried at a low temperature (100°C) for 7 days followed by 7 days of meat pan-fried at a high temperature (250°C). The low temperature-cooked meat had undetectable levels of heterocyclic amines (HAAs) while the high temperature-cooked meat contained high amounts of HAAs (2-amino-3,8-dimethylimidazo(4.5-f)quinoxaline (MeIQx) 9.0 ng/g, 2-amino-3,7,8-trimethylimidazo(4.5-f)quinoxaline (DiMeIQx) 2.1 ng/g and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) 32.8 ng/g). In contrast, total polycyclic aromatic hydrocarbon content was similar in both meat samples (10.7 ng/g in low temperature-cooked meat and 10.1 ng/g in high temperature-cooked meat). At the end of each period, subjects wee tested for CYP1A2 and NAT2 enzyme activity by caffeine metabolism phenotyping. NAT2 activity remained unchanged throughout the study while CYP1A2 activity increased in 72% of subjects after consuming high temperature-cooked meat (P<0.0002), suggesting induction by some compound(s) formed during high temperature cooking. If HAAs are shown to be human carcinogens in epidemiological studies, then meat cooked at high temperatures may pose an increased cancer risk because it contains both inducers of CYP1A2 and procarcinogens Me1Qx, DiMeIQx, and PhIP known to be activated by this enzyme. KW - carcinogenesis KW - carcinogens KW - cytochromes KW - frying KW - heterocyclic nitrogen compounds KW - meat KW - risk KW - temperature KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Meat Produce (QQ030) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408504&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of ethnic differences on the pattern of HTLV-I-associated T-cell leukemia/lymphoma (HATL) in the United States. AU - Levine, P. H. AU - Manns, A. AU - Jaffe, E. S. AU - Colclough, G. AU - Cavallaro, A. AU - Reddy, G. AU - Blattner, W. A. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1994/// VL - 56 IS - 2 SP - 177 EP - 181 SN - 0020-7136 AD - Levine, P. H.: National Cancer Institute, EPN #434, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005637. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health N2 - Although human T-cell lymphotropic virus type I (HTLV-I) is endemic in Japan and the Caribbean islands, the reported clinical and epidemiological features of adult T-cell leukaemia/lymphoma (ATL) in these 2 parts of the world are quite different. ATL has been diagnosed at a younger age and is reported more frequently as the lymphomatous type rather than the acute type with leukaemia in the Caribbean basin as compared with the presentation in Japan. In order to characterize ATL in the USA, a registry has been established at the National Cancer Institute for the purpose of recording all cases originally diagnosed in the USA. This registry was utilized to examine the effect of ethnic differences on age of onset and clinical features of ATL, using the same database. Clinical and laboratory information was obtained from 177 patients suspected of having ATL, who were treated at the National Institutes of Health, or had biological samples sent for evaluation, or were reported in the literature. Histopathological review and virological studies were performed by standardized methods. Of 177 patients registered, 127 were considered as having ATL, according to an algorithm combining clinical, pathological and laboratory features. Presenting features in the confirmed cases consisted primarily of lymphadenopathy (76.6%), hypercalcaemia (72.5%), leukaemia (82%), skin involvement (48.2%) and hepatomegaly (53.6%). Patients of Japanese ancestry were generally older (median age 63, range 51 to 73 years) than patients of African-American descent (median age 39, range 7 to 75 years) and presented more often with leukaemia (90% vs. 69%). Of the 103 cases where country of birth was confirmed, 45 (43.7%) were born in the USA. The prognosis was generally poor (median survival 3.24 months), but rare long-term remissions were documented. KW - adult t-cell leukaemia KW - disease prevalence KW - ethnicity KW - HTLV infections KW - human diseases KW - infections KW - leukaemia KW - neoplasms KW - North America KW - USA KW - Deltaretrovirus KW - human t-cell lymphotropic virus KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - adult T-cell leukemia KW - blood cancer KW - cancers KW - ethnic differences KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - leucaemia KW - leukemia KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005637&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Koumbalones A and B, new casbane diterpenes from Maprounea africana. AU - Kashman, Y. AU - Bernart, M. W. AU - Tischler, M. AU - Cardellina II, J. H. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1994/// VL - 57 IS - 3 SP - 426 EP - 430 SN - 0163-3864 AD - Kashman, Y.: Laboratory of Drug Discovery Research & Development, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702, USA. N1 - Accession Number: 19950301194. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Horticultural Science N2 - The organic extract of Maprounea africana roots (collected from the Central African Republic) yielded koumbalones A and B, defined by spectral methods as new variations on the casbane ring system. Their structures, relative configurations, and solution conformations were determined by a combination of spectral analyses and molecular modeling. Because koumbalone A spontaneously converts to koumbalone B at room temperature, koumblane B may be an artefact of isolation. KW - chemical structure KW - diterpenoids KW - medicinal plants KW - plant composition KW - roots KW - spectral analysis KW - Central African Republic KW - Euphorbiaceae KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Euphorbiaceae KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - chemical constituents of plants KW - drug plants KW - Maprounea KW - Maprounea africana KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Forests and Forest Trees (Biology and Ecology) (KK100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950301194&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii. AU - Fuller, R. W. AU - Cardellina, J. H., II AU - Cragg, G. M. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1994/// VL - 57 IS - 10 SP - 1442 EP - 1445 SN - 0163-3864 AD - Fuller, R. W.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950300282. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - A characteristic pattern of differential cytotoxicity of extracts of Iberis amara seeds, predominantly toward renal tumour, brain tumour and melanoma cell lines in the NCI human disease-oriented tumour screening panel, was traced to cucurbitacins E and I. This same differential cytotoxicity profile was detected in extracts of Begonia plebeja roots (collected from Belize) and Gonystylus keithii twigs (collected from Sarawak). Computer-assisted recognition of these profiles was followed by a rapid chemical fractionation, thus permitting the efficient dereplication of those extracts containing cucurbitacins B and D, respectively. This is the first report of cucurbitacins from the genus Gonystylus. KW - cell lines KW - cucurbitacins KW - cytotoxic compounds KW - cytotoxicity KW - isolation KW - plant composition KW - plant extracts KW - roots KW - seeds KW - stems KW - sterols KW - triterpenoids KW - Belize KW - Sarawak KW - Begonia KW - Begoniaceae KW - Brassicaceae KW - Gonystylus KW - Iberis KW - man KW - Thymelaeaceae KW - Begoniaceae KW - Violales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Capparidales KW - Thymelaeaceae KW - Myrtales KW - Brassicaceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Begonia KW - Gonystylus KW - Iberis KW - ACP Countries KW - Caribbean Community KW - Central America KW - America KW - Commonwealth of Nations KW - Developing Countries KW - Borneo KW - South East Asia KW - Asia KW - Malaysia KW - APEC countries KW - ASEAN Countries KW - Threshold Countries KW - Begonia plebeja KW - Capparales KW - chemical constituents of plants KW - Gonystylus keithii KW - Iberis amara KW - Thymelaeales KW - Plant Composition (FF040) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950300282&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Novel naphthoquinones from Conospermum incurvum. AU - Dai, J. R. AU - Decosterd, L. A. AU - Gustafson, K. R. AU - Cardellina, J. H., II AU - Gray, G. N. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1994/// VL - 57 IS - 11 SP - 1511 EP - 1516 SN - 0163-3864 AD - Dai, J. R.: Laboratory of Drug Discovery Research and Developmental, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950302631. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 130-15-4. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - During the re-isolation of the trimeric naphthoquinone derivative, conocurvone, from an extract of the roots of the Australian shrub, C. incurvum, 6 monomeric naphthoquinones were isolated (including 3 novel 1,4-naphthoquinone derivatives). The structures of the novel compounds were elucidated from spectral data. While conocurvone is a potent inhibitor of HIV-1-induced cell killing, all of the monomeric naphthoquinone derivatives were inactive against HIV-1. KW - chemical structure KW - human immunodeficiency viruses KW - medicinal plants KW - naphthoquinones KW - plant composition KW - roots KW - spectral analysis KW - Australia KW - Proteaceae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Proteales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - chemical constituents of plants KW - Conospermum incurvum KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Forests and Forest Trees (Biology and Ecology) (KK100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950302631&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thoracotomy for pulmonary mycoses in non-HIV-immunosuppressed patients. AU - Temeck, B. K. AU - Venzon, D. J. AU - Moskaluk, C. A. AU - Pass, H. I. JO - Annals of Thoracic Surgery JF - Annals of Thoracic Surgery Y1 - 1994/// VL - 58 IS - 2 SP - 333 EP - 338 SN - 0003-4975 AD - Temeck, B. K.: Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200293. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Of 36 immunosuppressed patients (28 men, 8 women, aged 4-59 yr) undergoing thoracotomy for the treatment of pulmonary fungal disease at the National Cancer Institute, Maryland, USA, during 1975-1993, the underlying causes of immunosuppression were malignancy (9 cases), Wegener's granulomatosis (4), haematological disorders (6) or chronic granulomatous disease of childhood (17). Symptoms present in 89% of patients included fever (27 cases), cough (20) and chest pain (14). Chest X-ray studies revealed the presence of cavitary disease in 7 patients, a mass in 8, infiltrates in 20 or cavity and infiltrate in 1. A preoperative diagnosis was lacking in 23 of the 36 patients. Procedures included wedge biopsy (13 cases), segmentectomy with or without wedge or chest wall resection (5), lobectomy with or without chest wall resection (16), wedge resection plus completion pneumonectomy (1) and segmentectomy plus completion pneumonectomy (1). Fungi identified included Aspergillus (23 cases), Zygomycetes (4), Cryptococcus neoformans (3) and Candida albicans, Coccidioides immitis, Conidiobolus incongruus, Histoplasma capsulatum, Sarcinosporon inkin and Wangiella dermatitidis in 1 patient each. Specific antifungal treatment was instituted in 34 patients (94%). Nine of 11 patients died of multiorgan system failure. Univariate analysis identified the following as prognostic of death during hospitalization: underlying haematological disease (P=0.012), angioinvasive disease (P=0.0064), treatment with chemotherapy and steroids (P=0.052), and a granulocyte percentage of ≤30% or a granulocyte count of ≤100 (P=0.048). Multivariate analysis revealed that angioinvasion correlated with all risk factors and operative mortality. 19 patients remained alive at a mean follow-up period of 2.8 yr. KW - aspergillosis KW - candidosis KW - coccidioidomycosis KW - cryptococcosis KW - histoplasmosis KW - hosts KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - infections KW - lungs KW - opportunistic infections KW - predisposition KW - surgery KW - therapy KW - zygomycosis KW - Maryland KW - USA KW - Ancylistaceae KW - Aspergillus KW - Candida albicans KW - Coccidioides immitis KW - Conidiobolus KW - Cryptococcus neoformans KW - Deuteromycotina KW - Entomophthoraceae KW - Exophiala dermatitidis KW - Histoplasma capsulatum KW - man KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Ancylistaceae KW - Entomophthorales KW - Entomophthoromycotina KW - Zygomycota KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Herpotrichiellaceae KW - Chaetothyriales KW - Conidiobolus KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Exophiala KW - Ajellomyces capsulatus KW - candidiasis KW - coccidiomycosis KW - Conidiobolus incongruus KW - european blastomycosis KW - fungus KW - Hyphomycetes KW - mitosporic fungi KW - phycomycosis KW - Sarcinosporon KW - Sarcinosporon inkin KW - therapeutics KW - United States of America KW - Wangiella KW - Wangiella dermatitidis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200293&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adult T-cell leukemia/lymphoma: a working point-score classification for epidemiological studies. AU - Levine, P. H. AU - Cleghorn, F. AU - Manns, A. AU - Jaffe, E. S. AU - Navarro-Roman, L. AU - Blattner, W. A. AU - Hanchard, B. AU - Oliveira, M. S. de AU - Matutes, E. AU - Catovsky, D. AU - Shimoyama, M. AU - Tajima, K. AU - Sonoda, S. AU - Yamaguchi, K. AU - Takatsuki, K. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1994/// VL - 59 IS - 4 SP - 491 EP - 493 SN - 0020-7136 AD - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010093. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - This report summarises current information regarding adult T-cell leukaemia/lymphoma (ATL) and proposes a classification facilitating comparison of case series in geographically and ethnically different populations. KW - human diseases KW - lymphoma KW - neoplasms KW - Deltaretrovirus KW - human t-cell lymphotropic virus KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010093&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determinants of total daily energy expenditure: variability in physical activity. AU - Rising, R. AU - Harper, I. T. AU - Fontvielle, A. M. AU - Ferraro, R. T. AU - Spraul, M. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1994/// VL - 59 IS - 4 SP - 800 EP - 804 SN - 0002-9165 AD - Rising, R.: National Institutes of Health, Clinical Diabetes and Nutrition Section, 4212 North 16th Street, Room 541-A, Phoenix, AZ 85016. USA. N1 - Accession Number: 19941406887. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition N2 - Excessive energy intake and/or reduced total daily energy expenditure (TEE) causes obesity. To examine the relation between obesity and TEE in an obesity-prone population, TEE, 24-h sedentary energy expenditure (SEDEE) and basal metabolic rate (BMR) were measured in 30 US Pima Indian men by the doubly labelled water method and a respiratory chamber. The energy expenditure for physical activity (EEACT) was calculated as TEE - (BMR + 0.1 TEE), where 10% of TEE is an estimate of the thermic effect of food. Fat-free mass was the best single determinant of TEE, explaining 48% of its variance. TEE, SEDEE, BMR and EEACT were 12010±2292, 9945±1559, 7677±1901 and 3297±1732 kJ/day, respectively. Because EEACT is dependent on body weight, EEACT/kg body weight and TEE/(BMR + 0.1 TEE) were used as indexes of the level of physical activity. Both indexes correlated negatively with percent body fat. The results suggest that obesity is associated with lower levels of physical activity. KW - energy exchange KW - ethnic groups KW - men KW - obesity KW - physical activity KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406887&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased risk of colorectal cancer among smokers: results of a 26-year follow-up of US veterans and a review. AU - Heineman, E. F. AU - Zahm, S. H. AU - McLaughlin, J. K. AU - Vaught, J. B. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1994/// VL - 59 IS - 6 SP - 728 EP - 738 SN - 0020-7136 AD - Heineman, E. F.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19962001394. Publication Type: Journal Article. Language: English. Number of References: 72 ref. Subject Subsets: Public Health N2 - A cohort of 248 046 American veterans (followed prospectively for 26 years) was evaluated to clarify the relationship between tobacco use and risk of colorectal cancer. In comparison with veterans who had never used tobacco, the risk of death was significantly increased for colon cancer and rectal cancer among current and former cigarette smokers and among pipe or cigar smokers, controlling for social class and occupational physical activity. Users of chewing tobacco or snuff also showed a significantly elevated rectal-cancer risk. For both sites, risk increased significantly with pack-years, earlier age at first use, and number of cigarettes. These results reinforce 2 recent reports of the association of cigarette smoking and colorectal cancer in men and women. Inconsistencies in the findings of earlier epidemiological studies appear to be due in large part to differences in length of follow-up or in choice of controls. Studies with at least 20 years of follow-up or population-based controls have tended to find elevated risk with tobacco smoking, while those with shorter follow-up or hospital controls have not. This, plus the strength and consistency of the association of smoking and colon polyps, suggest that smoking may primarily affect an early stage in the development of colon cancer. If this association is causal, tobacco use may be responsible for 16% of colon-cancer and 22% of rectal-cancer deaths among these veterans. KW - colon KW - colorectal cancer KW - epidemiology KW - human diseases KW - neoplasms KW - rectum KW - risk factors KW - tobacco smoking KW - toxicology KW - veterans KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - United States of America KW - war veterans KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy intake and physical activity in relation to indexes of body fat: the National Heart, Lung, and Blood Institute Growth and Health Study. AU - Obarzanek, E. AU - Schreiber, G. B. AU - Crawford, P. B. AU - Goldman, S. R. AU - Barrier, P. M. AU - Frederick, M. M. AU - Lakaos, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1994/// VL - 60 IS - 1 SP - 15 EP - 22 SN - 0002-9165 AD - Obarzanek, E.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941408052. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - The relation between energy intake, physical activity, and body fat was investigated in the baseline visit of 2379 black and white US girls 9-10 years old. 3-day food records, 3-day physical activity diaries, physical-activity pattern questionnaires, and an assessment of the length of time spent watching television and videos were obtained. Multivariate-regression analyses showed that age, number of hours of television and video watching, percent of energy from saturated fatty acids, and activity-pattern score best explained the variation in body mass index and sum of 3 skinfold-thickness measurements for black girls. The best model for white girls included age, number of hours of television and video watching, and percent of energy from total fat. The results indicate that body fatness is related to energy intake and expenditure in black and white girls. Longitudinal studies will help assess the value of these variables in predicting changes in body fat. KW - body fat KW - children KW - diet studies KW - energy intake KW - ethnic groups KW - girls KW - nutrition surveys KW - obesity KW - physical activity KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - nutritional surveys KW - United States of America KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408052&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database. AU - Yong, L. C. AU - Forman, M. R. AU - Beecher, G. R. AU - Graubard, B. I. AU - Campbell, W. AU - Reichman, M. E. AU - Taylor, P. R. AU - Lanza, E. AU - Holden, J. AU - Judd, J. T. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1994/// VL - 60 IS - 2 SP - 223 EP - 230 SN - 0002-9165 AD - Yong, L. C.: Cancer Prevention Studies Branch, DCPC, National Cancer Institute, EPN-211, Rockville, MD 20892, USA. N1 - Accession Number: 19941409972. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - The diet-plasma relations for carotenoids were examined in a group of 98 nonsmoking premenopausal women who participated in the cross-sectional phase of the National Cancer Institute (NCI)-US Department of Agriculture (USDA) diet study on alcohol-hormone metabolism, l988-90. With use of the newly developed USDA-NCI carotenoid food composition database, the mean daily intakes of carotenoids were significantly higher when estimated from the food-frequency questionnaire (FFQ) than from the 7-day diet records. Lycopene, lutein plus zeaxanthin, and β-carotene were the major plasma carotenoids. After adjustment for body mass index, energy and alcohol intakes, and total plasma cholesterol concentration, significant correlations were observed between the diet record and the FFQ-estimated carotenoid intakes and their respective plasma concentrations. The data indicated that plasma carotenoid concentrations were reflective of the dietary intake, but the magnitude of the correlation varied depending on the specific carotenoid and on the dietary assessment tool. KW - blood KW - carotenoids KW - databases KW - diet studies KW - food composition KW - intake KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - data banks KW - tetraterpenoids KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409972&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resting metabolic rate of anorexia nervosa patients during weight gain. AU - Obarzanek, E. AU - Lesem, M. D. AU - Jimerson, D. C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1994/// VL - 60 IS - 5 SP - 666 EP - 675 SN - 0002-9165 AD - Obarzanek, E.: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA. N1 - Accession Number: 19951402478. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Subject Subsets: Human Nutrition N2 - To examine whether changes in energy metabolism may contribute to the difficulty of weight gain observed in anorexic patients, resting metabolic rate (RMR) and neuroendocrine function were studied in 10 patients diagnosed with anorexia nervosa. RMR per kilogram lean body mass was not significantly different from that of healthy subjects on admission (95.9±5.6 vs. 103.6±3.3 kJ/kg, respectively), during early refeeding (108.6±6.9 kJ/kg), or at target weight (102.1±3.8 kJ/kg). At late refeeding, RMR was significantly higher (132.1±4.9 kJ/kg, P<0.0001). There were no significant correlations between plasma norepinephrine and thyroid hormones and RMR. The increase in RMR during refeeding is at least double that observed in other studies in which normal-weight subjects are experimentally overfed or experimentally underfed and then refed. The results suggest that the increase in RMR during refeeding is disproportionate to weight gain and this large magnitude of increase may be unique to anorexia nervosa. KW - anorexia nervosa KW - energy metabolism KW - heat production KW - patients KW - refeeding KW - resting energy exchange KW - weight gain KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorigenesis KW - thermogenesis KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Eating behavior in bulimia nervosa: multiple meal analyses. AU - Hetherington, M. M. AU - Altemus, M. AU - Nelson, M. L. AU - Bernat, A. S. AU - Gold, P. W. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1994/// VL - 60 IS - 6 SP - 864 EP - 873 SN - 0002-9165 AD - Hetherington, M. M.: Clinical Neuroendocrinology Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA. N1 - Accession Number: 19951402517. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - 10 bulimic individuals were admitted to an inpatient unit and for 7 consecutive days eating behaviour was observed and recorded. Age-, sex- and weight-matched control subjects (n = 10) were admitted to the same unit for 4 days. All food and fluid intake, frequency of binge eating and purging, and ratings of appetite and mood before and after eating were recorded every 24 h. Bulimic patients demonstrated chaotic eating patterns that varied within as well as between individuals. Total daily energy intake was significantly higher for bulimic patients than for control subjects. On average, patients binged 1.6 times, purged 3 times and ate one snack or meal without purging daily. Macronutrient analyses of intake revealed significantly less energy from protein and more energy from fat in bulimic patients compared with control subjects. Some improvement of mood was noted after binges, the magnitude of which was greatest after purging. KW - analysis KW - appetite KW - appetite disorders KW - behaviour KW - bulimia KW - feeding behaviour KW - meals KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - binge eating KW - bulimia nervosa KW - eating disorders KW - feeding behavior KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil). AU - Mock, B. A. AU - Holiday, D. L. AU - Cerretti, D. P. AU - Darnell, S. C. AU - O'Brien, A. D. AU - Potter, M. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 1 SP - 325 EP - 328 SN - 0019-9567 AD - Mock, B. A.: Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19950810320. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology; Animal Breeding N2 - The interval of mouse chromosome 1 extending from Idh-1 to Pep-3 harbours the natural resistance gene Ity/Lsh/Bcg; it controls the outcome of infection with Salmonella typhimurium, Leishmania donovani, and several Mycobacterium species. This region also contains a DNA repair gene, Rep-1, which determines the rapidity with which double-strand breaks in chromatin are repaired. BALB/cAnPt and DBA/2N mice differ in their phenotypic expression of these genes. To generate appropriate strains of mice for the study of these genes, a series of 10 C.D2 congenic strains recombinant across a 28-centimorgan interval of mouse chromosome 1 extending from Idh-1 to Pep-3 were derived from crosses of the C.D2-Idh-1Pep-3 congenic strain back to BALB/cAn. Analyses of these recombinant strains will allow the correlation of biological-immunological phenotypes with defined genetic regions. KW - congenic strains KW - disease resistance KW - DNA KW - DNA repair KW - genes KW - genetics KW - parasites KW - resistance KW - strains KW - Leishmania donovani KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - BCG resistance KW - congenic KW - deoxyribonucleic acid KW - immunity to Salmonella typhimurium KW - leishmaniasis resistance KW - repair KW - resistance to disease KW - villin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950810320&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Size heterogeneity among antigenically related Giardia lamblia variant-specific surface proteins is due to differences in tandem repeat copy number. AU - Mowatt, M. R. AU - Nguyen, B. Y. T. AU - Conrad, J. T. AU - Adam, R. D. AU - Nash, T. E. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 4 SP - 1213 EP - 1218 SN - 0019-9567 AD - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804774. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - An epitope that is conserved among variant-specific surface proteins (VSPs) expressed by cloned trophozoite lines derived from the independent Giardia lamblia [Giardia duodenalis] isolates WB, G3M, Be-2 and CAT was studied. The epitope recognized by MAb 6E7 lies entirely within the region of tandemly repeated 65-amino acid units that is characteristic of these size-variant VSPs. Northern (RNA) hybridization, cDNA cloning and DNA sequence analysis indicated that size heterogeneity among these VSPs is due to differences in the number of repetitive units. KW - amino acid sequences KW - antigenic variation KW - antigens KW - genes KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804774&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phagocytosis of medically important yeasts by polymorphonuclear leukocytes. AU - Lyman, C. A. AU - Walsh, T. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 4 SP - 1489 EP - 1493 SN - 0019-9567 AD - Lyman, C. A.: T. J. Walsh, Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200670. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Using a modified fluorescence quenching assay to distinguish between attached and ingested organisms, percent phagocytosis of several medically important yeasts was determined. The percentages of phagocytosis of serum-opsonized Candida albicans, C. tropicalis, C. parapsilosis and Torulopsis glabrata were all comparable at 37°C. There was significantly less phagocytosis of Cryptococcus neoformans and Trichosporon beigelii isolates (P<0.001). It is concluded that phagocytosis of Candida albicans by polymorphonuclear leukocytes is comparable to that of species other than C. albicans but is significantly greater than that of the basidiomycetous yeasts T. beigelii and Cryptococcus neoformans. KW - immunology KW - neutrophils KW - phagocytosis KW - yeasts KW - Candida albicans KW - Candida glabrata KW - Candida parapsilosis KW - Candida tropicalis KW - Cryptococcus neoformans KW - Trichosporon beigelii KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Torulopsis KW - Pezizomycotina KW - Trichosporon KW - Trichosporonaceae KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200670&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti. AU - Raghavan, N. AU - Freedman, D. O. AU - Fitzgerald, P. C. AU - Unnasch, T. R. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 5 SP - 1901 EP - 1908 SN - 0019-9567 AD - Raghavan, N.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940803469. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9001-06-3. Subject Subsets: Helminthology N2 - While there is no direct evidence demonstrating the existence of protective immunity to Wuchereria bancrofti infection in humans, the presence of individuals, in populations in areas where infection is endemic, with no clinical evidence of past or current infection despite appreciable exposure to the infective larvae, suggests that protective immunity to filarial parasites may occur naturally. Earlier work indicated that such putatively immune individuals generated antibodies to a 43 000 MW antigen from larval extracts of Brugia malayi that was recognized by only 8% of the infected population. With rabbit antiserum raised against this 43 000 MW antigen, a recombinant clone, WbN43, with an insert size of 2.3 kb, was identified from a Wuchereria bancrofti genomic expression library. The recombinant fusion protein was differentially recognized by the putatively immune individuals but not by the infected patients. The coding sequence (684 bp) from the 5′ end had significant sequence similarity to chitinases from Serratia marcescens, Bacillus circulans, Streptomyces plicatus, and B. malayi. Peptide sequencing of the expressed product also defined a chitinase-like sequence. Molecular characterization indicated WbN43 to be a low-copy-number gene, with expression predominantly in infective larvae and microfilariae but not in adult parasites. KW - antigens KW - chitinase KW - helminths KW - human diseases KW - immunity KW - molecular genetics KW - nucleotide sequences KW - parasites KW - recombinant antigens KW - man KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - immunogens KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803469&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Giardia lamblia infections in adult mice. AU - Byrd, L. G. AU - Conrad, J. T. AU - Nash, T. E. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 8 SP - 3583 EP - 3585 SN - 0019-9567 AD - Byrd, L. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940807147. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology N2 - An adult mouse-Giardia lamblia [Giardia duodenalis] model was developed and used to study host-parasite interactions, including antigenic variation. The H7/1 clone of isolate GS infected mice consistently and produced infections in 14 mouse strains tested. Infection patterns were mouse strain and Giardia isolate dependent. Antigenic variation occurred in immunocompetent mice but not in mice with severe combined immunodeficiency. KW - animal models KW - experimental infections KW - giardiasis KW - host parasite relationships KW - laboratory animals KW - parasites KW - strains KW - Giardia duodenalis KW - Hexamitidae KW - mice KW - Muridae KW - protozoa KW - rodents KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - giardiosis KW - parasite host relationships KW - Laboratory Animal Science (LL040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940807147&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HYP1, a hydrophobin gene from Aspergillus fumigatus, complements the rodletless phenotype in Aspergillus nidulans. AU - Parta, M. AU - Chang, Y. AU - Rulong, S. AU - Pinto-DaSilva, P. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1994/// VL - 62 IS - 10 SP - 4389 EP - 4395 SN - 0019-9567 AD - Parta, M.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19951203330. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - A. fumigatus produces conidia that are highly dispersible and resistant to degradation. These properties were analysed by studying the rodlets which form the outer spore coat protein. Degenerate primers based on hydrophobins in other fungi were applied to genomic DNA from A. fumigatus in PCR. A product of this reaction with similarity to an A. nidulans gene as judged by Southern hydridization was chosen for further study. Cloning and sequencing revealed a gene with 2 introns which encodes a protein of 159 amino acids. Structural characteristics consistent with those of other fungal hydrophobin genes, especially conserved cysteine residues, are present. The expression of the gene is limited to the developmental stages in which maturing conidiophores are present. This A. fumigatus gene, HYP1, was used to transform a mutant strain of A. nidulans that lacks rodlets. Transformants with a single copy of HYP1, was used to transform a mutant strain of A. nidulans that lacks rodlets. Transformants with a single copy of HYP1 expressed a rodlet layer on their conidia as observed by freeze-fracture electron microscopy. KW - genes KW - genetics KW - mutants KW - nucleotide sequences KW - phenotypes KW - Aspergillus fumigatus KW - Emericella nidulans KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Emericella KW - Aspergillus nidulans KW - DNA sequences KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression and antigenicity of Plasmodium falciparum major merozoite surface protein (MSP119) variants secreted from Saccharomyces cerevisiae. AU - Kaslow, D. C. AU - Hui, G. AU - Kumar, S. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1994/// VL - 63 IS - 2 SP - 283 EP - 289 SN - 0166-6851 AD - Kaslow, D. C.: Molecular Vaccine Section, Building 4, Room B1-37, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802834. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Four antigenic variants of the 19 kDa carboxy terminal fragment of Plasmodium falciparum merozoite surface protein, MSP1 (MSP119), were expressed in Saccharomyces cerevisiae as histidine-tagged, secreted polypeptides (rMSP119s). Structural analysis of the rMSP119s indicated that a single amino acid change (E to Q) in the first EGF-like domain of the yeast-secreted rMSP19 proteins caused a significant change in their disulfide bond-dependent conformation. The antigenicity of the rMSP119s were qualitatively and quantitatively analyzed by direct and competitive binding ELISAs. The data indicated that conserved and variant B cell determinants of MSP119, as well as epitopes that are known targets of protective antibodies, were recreated authentically in the rMSP119s.From AS<new para>ADDITIONAL ABSTRACT:<new para>Four antigenic variants of the 19 000 MW carboxy terminal fragment of Plasmodium falciparum merozoite surface protein, MSP1 (MSP119), were expressed in Saccharomyces cerevisiae as histidine-tagged, secreted polypeptides (rMSP119s). Structural analysis of the rMSP119s indicated that a single amino acid change (E to Q) in the first EGF-like domain of the yeast-secreted rMSP19 proteins caused a significant change in their disulfide bond-dependent conformation. The antigenicity of the rMSP119s were qualitatively and quantitatively analyzed by direct and competitive binding ELISAs. The data indicated that conserved and variant B cell determinants of MSP119, as well as epitopes that are known targets of protective antibodies, were recreated authentically in the rMSP119s. KW - amino acid sequences KW - antigenic variation KW - antigens KW - epitopes KW - Merozoites KW - parasites KW - Proteins KW - recombinant proteins KW - surface antigens KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic determinants KW - antigenic polymorphism KW - antigenicity KW - immunogens KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802834&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes. AU - Dolan, S. A. AU - Proctor, J. L. AU - Alling, D. W. AU - Okubo, Y. AU - Wellems, T. E. AU - Miller, L. H. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1994/// VL - 64 IS - 1 SP - 55 EP - 63 SN - 0166-6851 AD - Dolan, S. A.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, NIH Building 4, Room 126 Bethesda, MD 20892, USA. N1 - Accession Number: 19940805184. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Four clones of Plasmodium falciparum with differing specificities for erythrocyte invasion were studied using erythrocytes that are mutant for either glycophorin A or B, and enzyme modification of the erythrocyte surface with neuraminidase and trypsin. Neuraminidase alone abolished invasion of 2 parasite clones (Dd2, FCR3/A2: these invade after trypsin treatment alone). A 3rd clone (7G8) was unable to invade trypsin-treated erythrocytes. The 4th-clone (HB3) was able to invade after either neuraminidase or trypsin treatment. The receptor for invasion of trypsin-treated erythrocytes was explored in 2 ways: treatment of trypsin-treated normal cells with neuraminidase, and trypsin treatment of glycophorin B-deficient cells. Both treatments eliminated invasion by all clones, indicating that the trypsin-independent pathway uses sialic acid and glycophorin B. To identify parasite proteins involved in the different pathways, erythrocyte binding assays were performed with soluble parasite proteins from each clone. Based on binding assays using erythrocytes that lack glycophorin A, the parasite protein known as EBA-175 appears to bind predominantly to glycophorin A. In contrast, the glycophorin B pathway does not appear to involve EBA-175, as binding of EBA-175 was similarly reduced to trypsin-treated normal and trypsin-treated glycophorin B-deficient erythrocytes. The glycophorin B-dependent, sialic acid-dependent invasion of trypsin-treated normal erythrocytes uses a different parasite ligand, indicating 2 or more sialic-dependent pathways for invasion. Clone 7G8, which cannot invade trypsin-treated erythrocytes, may be missing the ligand for invasion via glycophorin B. Redundancy in the invasion process may give a selective advantage to parasites that must survive in polymorphic human populations. KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - human diseases KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - blood red cells KW - glycophorin B KW - glycophorins KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805184&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetoplastida display naturally occurring ancillary DNA-containing structures. AU - Miyahira, Y. AU - Dvorak, J. A. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1994/// VL - 65 IS - 2 SP - 339 EP - 349 SN - 0166-6851 AD - Miyahira, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, Room 106, 12441 Parklawn Drive, Rockville, MD 20852-1727, USA. N1 - Accession Number: 19950800977. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology N2 - Kinetoplast-derived, DNA-containing structures were found in several members of the order Kinetoplastida. The structures, for which the name ancillary DNA-containing structures (aDNA) is proposed, were discovered during the course of low-light-level video fluorescence microscopy studies using several nucleic acid-specific fluorescent reagents. DNase treatment and supravital stain with Höechst 33342 confirmed that aDNA is not an artifact of specimen preparation. Fluorescent in situ hybridization using either a 122-bp kinetoplast DNA-specific probe derived from a conserved region of minicircle DNA or a 188-bp nuclear DNA-specific probe derived from highly repetitive nuclear DNA demonstrated that aDNA is derived from the kinetoplast and not the nucleus. However, the structures do not contain minicircle DNA replication intermediates. Immunofluorescence assays using an anti-mitochondrial protein antibody, anti-mtp 70, demonstrated that the structures contain mitochondrial protein and confirmed their kinetoplast origin. The frequency of occurrence of aDNA varies markedly between members of the Kinetoplastida. In the case of Trypanosoma cruzi stocks, the percentage of cells with aDNA was positively correlated to the population doubling time of the stock. However, there was no statistically significant relationship between the developmental or replicative stage of the parasite and the frequency of aDNA. An inhibitor of DNA topoisomerase I had no effect upon the frequency of aDNA. An inhibitor of DNA topoisomerase II gave equivocal results depending upon the parasite stock used. It is speculated that aDNA may be the morphological consequence of a yet-to-be-determined biological process intrinsic to, but variable within, the Kinetoplastida. KW - DNA KW - human diseases KW - molecular genetics KW - parasites KW - Kinetoplastida KW - protozoa KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - ancillary DNA KW - biochemical genetics KW - deoxyribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800977&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Host specificity of ribosomal DNA variation in sylvatic Trypanosoma cruzi from North America. AU - Clark, C. G. AU - Pung, O. J. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1994/// VL - 66 IS - 1 SP - 175 EP - 179 SN - 0166-6851 AD - Clark, C. G.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Building 4/Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801110. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Eighteen sylvatic trypanosome isolates (13 from raccoon Procyon lotor, 4 from opossum Didelphis marsupialis and one from Triatoma sanguisuga, all from Georgia, USA, except one from raccoon in Maryland) and 4 human Trypanosoma cruzi reference strains (all from Brazil) were studied. Riboprinting (based on digesting PCR amplified SSU-rDNA) of the 17 sylvatic isolates from mammals resulted in 2 distinct patterns that corelated with the host from which they had been cultured, one pattern being seen only in the opossum isolates, the other in the raccoon isolates. The riboprint obtained for the isolate from Triatoma sanguisuga was identical to those of the raccoon isolates. The term "ribodeme" is coined for populations which share the same riboprint pattern: ribodeme I consisted of the raccoon, Triatoma sanguisuga and 3 of the human isolates, ribodeme II of the opossum isolates, and ribodeme III of one of the human isolates. Findings in the North American isolates are consistent with a "founder effect" and vertical transmission. It is suggested that Trypanosoma cruzi may only have entered once into the population of each mammal species in the area. KW - Chagas' disease KW - disease vectors KW - epidemiology KW - human diseases KW - molecular genetics KW - molecular taxonomy KW - parasites KW - ribosomal DNA KW - Georgia KW - Maryland KW - USA KW - Didelphis marsupialis KW - Hemiptera KW - Procyon lotor KW - protozoa KW - Reduviidae KW - Sarcomastigophora KW - Triatoma sanguisuga KW - Triatominae KW - Trypanosoma cruzi KW - Trypanosomatidae KW - Didelphis KW - Didelphidae KW - Didelphimorphia KW - marsupials KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - Procyon KW - Procyonidae KW - Fissipeda KW - carnivores KW - Heteroptera KW - Hemiptera KW - Protozoa KW - Reduviidae KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Triatoma KW - Triatominae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southeastern States of USA KW - biochemical genetics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801110&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments. AU - Schubert, U. AU - Strebel, K. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 4 SP - 2260 EP - 2271 SN - 0022-538X AD - Schubert, U.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003366. Publication Type: Journal Article. Language: English. Number of References: 49 ref. KW - activity KW - human diseases KW - localization KW - Vpu protein KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003366&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of humam immunodeficiency virus type 1. AU - Van Lint, C. AU - Ghysdael, J. AU - Paras, P. Jr. AU - Burny, A. AU - Verdin, E. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 4 SP - 2632 EP - 2648 SN - 0022-538X AD - Van Lint, C.: Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003362. Publication Type: Journal Article. Language: English. Number of References: 93 ref. KW - genes KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - nucleotide sequences KW - pol gene KW - regulation KW - transcription KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA sequences KW - DNA transcription KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spontaneous substitutions in the vicinity of the V3 analog affect cell tropism and pathogenicity of simian immunodeficiency virus. AU - Hirsch, V. M. AU - Martin, J. E. AU - Dapolito, G. AU - Elkins, W. R. AU - London, W. T. AU - Goldstein, S. AU - Johnson, P. R. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 4 SP - 2649 EP - 2661 SN - 0022-538X AD - Hirsch, V. M.: Immunodeficiency Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Twinbrook Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA. N1 - Accession Number: 19952003373. Publication Type: Journal Article. Language: English. Number of References: 54 ref. KW - animal models KW - envelope proteins KW - mutations KW - pathogenicity KW - tropisms KW - man KW - simian immunodeficiency virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003373&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type 1 strains: evidence for interspecies transmission. AU - Koralnik, I. J. AU - Boeri, E. AU - Saxinger, W. C. AU - Lo Monico, A. AU - Fullen, J. AU - Gessian, A. AU - Guo, H-G. AU - Gallo, R. C. AU - Markham, P. AU - Kalyanaraman, V. AU - Hirsch, V. AU - Allan, J. AU - Murthy, K. AU - Alford, P. AU - Slattery, J. P. AU - O'Brien, S. J. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 4 SP - 2693 EP - 2707 SN - 0022-538X AD - Koralnik, I. J.: Correspondence address: G. Franchini, Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm 6H01, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003364. Publication Type: Journal Article. Language: English. Number of References: 62 ref. KW - ancestry KW - env gene KW - human diseases KW - phylogeny KW - transmission KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - HTLV-BLV group KW - simian T-cell leukaemia/lymphotropic virus type I KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003364&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of minireovirus as a Norwalk-like virus in pediatric patients with gastroenteritis. AU - Lew, J. F. AU - Petric, M. AU - Kapikian, A. Z. AU - Jiang, X. AU - Estes, M. K. AU - Green, K. Y. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 5 SP - 3391 EP - 3396 SN - 0022-538X AD - Lew, J. F.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 7, Rm 129, 5000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010411. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - In 1977, 30- to 32-nm virus-like particles, named minireovirus because of their unique morphologic appearance, were detected by electron microscopy in the stools of Canadian infants and young children with gastroenteritis. Sequence analysis of approximately 2 800 consecutive bases derived from overlapping PCR clones of a recent minireovirus clinical isolate showed 52% nucleotide sequence identity with the Norwalk virus sequence and, in addition, demonstrated that the genomic organizations of these two viruses were similar. These data show that minireovirus is a Norwalk-like virus and should now also be included in the Caliciviridae family. KW - children KW - gastroenteritis KW - human diseases KW - identification KW - infants KW - Canada KW - North America KW - Caliciviridae KW - man KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Norovirus KW - Caliciviridae KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - minireovirus KW - Norwalk-like virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010411&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope. AU - Willey, R. L. AU - Theodore, T. S. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 7 SP - 4409 EP - 4419 SN - 0022-538X AD - Willey, R. L.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952006358. Publication Type: Journal Article. Language: English. Number of References: 60 ref. KW - amino acids KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006358&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex Class II expression and CD4+ T cells. AU - Giese, N. A. AU - Giese, T. AU - Morse, H. C. III JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 9 SP - 5819 EP - 5824 SN - 0022-538X AD - Giese, N. A.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001713. Publication Type: Journal Article. Language: English. Number of References: 23 ref. KW - animal models KW - antigens KW - CD4+ lymphocytes KW - human diseases KW - major histocompatibility complex KW - pathogenesis KW - mice KW - Retroviridae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenicity KW - CD4+ cells KW - histocompatibility complex KW - immunogens KW - murine AIDS KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001713&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. AU - Engelman, A. AU - Hickman, A. B. AU - Craigie, R. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 9 SP - 5911 EP - 5917 SN - 0022-538X AD - Engelman, A.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001702. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2. KW - binding KW - DNA KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - processing KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001702&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A lion lentivirus related to feline immunodeficiency virus: epidemiologic and phylogenetic aspects. AU - Brown, E. W. AU - Yuhki, N. AU - Packer, C. AU - O'Brien, S. J. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 9 SP - 5953 EP - 5968 SN - 0022-538X AD - Brown, E. W.: Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19942217183. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 9068-38-6. Subject Subsets: Veterinary Science; Veterinary Science N2 - A serological survey for antibodies to feline immunodeficiency virus (FIV) detected an endemic lentivirus in 90% of over 400 free-ranging African and Asian lions (Panthera leo). A lion lentivirus (FIV-Ple) was isolated by infection of lion lymphocytes in vitro. Seroconversion was found in 2 Serengeti lions. There was no evidence for maternal transmission as a major route of infections in lions. A phylogenetic analysis of cloned FIV-Ple pol gene sequences from 27 lions from 4 African populations (Serengeti Reserve, Ngorongoro Crater, Lake Manyara and Kruger Park) detected high intra- and interindividual genetic diversity. Three FIV-Ple phylogenetic clusters or clades were identified with phenetic, parsimony and likelihood analyses. The 3 clades, which occurred not only together in the same population but throughout Africa, were as divergent from each other as were homologous pol sequences of lentivirus isolates from distinct feline species such as the puma and domestic cat. The FIV-Ple clades were more closely related to each other than to other feline lentiviruses (monophyletic for lion species), suggesting that the ancestors of FIV-Ple evolved in geographically isolated lion populations that converged recently. There is no clear evidence of FIV-Ple-associated pathology, suggesting a historic genetic accomodation of the lion lentivirus to its host leading to coevolved host-parasite symbiosis (or commensalism) in the population similar to that suggested for endemic simian immunodeficiency virus without pathology in free-ranging African monkey species. KW - immunoblotting KW - molecular biology KW - nucleotide sequences KW - phylogeny KW - polymerase chain reaction KW - reverse transcriptase KW - viral diseases KW - Africa KW - Felidae KW - feline immunodeficiency virus KW - lentivirus KW - man KW - Panthera KW - retroviridae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - Felidae KW - DNA sequences KW - PCR KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942217183&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences. AU - Vicenzi, E. AU - Dimitrov, D. S. AU - Engelman, A. AU - Migone, T. S. AU - Purcell, D. F. J. AU - Leonard, J. AU - Englund, G. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 12 SP - 7879 EP - 7890 SN - 0022-538X AD - Vicenzi, E.: Correspondence address: M. A. Martin, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007089. Publication Type: Journal Article. Language: English. Number of References: 60 ref. KW - deletions KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - long terminal repeat KW - nucleotide analysis KW - U5 region KW - viral DNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007089&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II. AU - Giri, A. AU - Markham, P. AU - Digilio, L. AU - Hurteau, G. AU - Gallo, R. C. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1994/// VL - 68 IS - 12 SP - 8392 EP - 8395 SN - 0022-538X AD - Giri, A.: Correspondence address: G. Franchini, Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A01, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007042. Publication Type: Journal Article. Language: English. Number of References: 24 ref. KW - human diseases KW - chimpanzees KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - human t-cell lymphotropic virus type ii KW - man KW - retroviridae KW - Pan KW - Pongidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - HTLV-BLV group KW - simian T-cell lymphotropic virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007042&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of human immunodeficiency virus infection in children. AU - Willoughby, A. JO - Annals of Allergy JF - Annals of Allergy Y1 - 1994/// VL - 72 IS - 3 SP - 185 EP - 193 SN - 0003-4738 AD - Willoughby, A.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA. N1 - Accession Number: 19952010562. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - children KW - epidemiology KW - human diseases KW - human immunodeficiency viruses KW - infections KW - reviews KW - viral diseases KW - North America KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - human immunodeficiency virus KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010562&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The price of mammography in the United States: data from the National Survey of mammography facilities. AU - Breen, N. AU - Brown, M. L. JO - Milbank Quarterly JF - Milbank Quarterly Y1 - 1994/// VL - 72 IS - 3 SP - 431 EP - 450 SN - 0887-378X AD - Breen, N.: (N. Breen) Applied Research Branch, National Cancer Institute, Executive Plaza North, Room 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19952000732. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health N2 - This paper deals with costs in the USA specificially. In many other countries with screening programmes such as the UK cost is not an issue. Danielle Horton KW - breast KW - breast cancer KW - costs KW - neoplasms KW - screening KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - costings KW - screening tests KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000732&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary effects on exercising muscle metabolism and performance by 31P-MRS. AU - Larson, D. E. AU - Hesslink, R. L. AU - Hrovat, M. I. AU - Fishman, R. S. AU - Systrom, D. M. JO - Journal of Applied Physiology JF - Journal of Applied Physiology Y1 - 1994/// VL - 77 IS - 3 SP - 1108 EP - 1115 SN - 8750-7587 AD - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19951413544. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 67-07-2. Subject Subsets: Human Nutrition N2 - The effect of diet on short-term exercise capacity, skeletal muscle pH and bioenergetic state was investigated by 31P-magnetic resonance spectroscopy in 5 male and 4 female, healthy adults. Subjects performed incremental quadriceps exercise to exhaustion after 5 days of high-carbohydrate (HCHO) or high-fat (HFAT) diet randomly assigned in crossover design and separated by a 2.5-day period of ad libitum mixed diet. Simultaneous measurements were made of pulmonary gas exchange, minute ventilation and quadriceps muscle pH and phosphorylation potential. At rest and peak exercise, respiratory exchange ratio and minute ventilation were higher after HCHO than after HFAT (P<0.05), indicating greater CHO utilization. HCHO did not increase peak oxygen consumption (VO2) but increased exercise duration (339±34 s for HCHO vs. 308±25 s for HFAT; P<0.05). HCHO was associated with a blunted early decrease in phosphocreatine (PCr)/P intracellular (Pi) vs. VO2 (-4.1±0.7 × 10-2 min/ml for HCHO vs. -5.6±1.2 × 10-2 for HFAT; P<0.05). The slope of PCr/Pi vs. VO2, before and after the PCr-threshold, was correlated with exercise time. Results suggest that a dietary intake high in CHO improves exercise efficiency through beneficial effects on intracellular phosphorylation potential. KW - adults KW - carbohydrate metabolism KW - carbohydrates KW - exercise KW - fats KW - glycolysis KW - intake KW - metabolism KW - oxygen consumption KW - performance KW - pH KW - phosphocreatine KW - skeletal muscle KW - spectroscopy KW - ventilation KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - creatine phosphate KW - hydrogen ion concentration KW - potential of hydrogen KW - saccharides KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413544&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Complementation of an Escherichia coli glycolysis mutant by Giardia lamblia triosephosphate isomerase. AU - Mowatt, M. R. AU - Weinbach, E. C. AU - Howard, T. C. AU - Nash, T. E. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 78 IS - 1 SP - 85 EP - 92 SN - 0014-4894 AD - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802328. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The Giardia lamblia triosephosphate isomerase (TIM) gene was cloned using a probe generated by a polymerase chain reaction employing primers complementary to highly conserved regions of TIM. The nucleotide sequence predicts a protein 38 and 47% identical to TIM from prokaryotic and eukaryotic sources, respectively. The TIM gene lacks introns and is transcribed to yield a polyadenylated mRNA with an extremely short 5′ untranslated region. The Giardia TIM gene complemented an Escherichia coli triosephosphate isomerase deletion mutant. KW - complementation KW - enzymes KW - genes KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Giardia duodenalis KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - Escherichia coli glycolysis KW - triosephosphate isomerase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802328&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma gondii: acquired ocular toxoplasmosis in the murine model, protective role of TNF-α and IFN-γ. AU - Gazzinelli, R. T. AU - Brézin, A. AU - Li, Q. AU - Nussenblatt, R. B. AU - Chan, C. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 78 IS - 2 SP - 217 EP - 229 SN - 0014-4894 AD - Gazzinelli, R. T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940802798. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Protozoology; Tropical Diseases N2 - The eyes and brains from C57BL/6 mice infected with an avirulent strain of Toxoplasma gondii (ME49) were studied. Focal ocular inflammation and retinal pigment epithelial involvement were commonly observed after 15 days of infection. Four weeks pi a stable number of cysts was observed in the brain but rarely in the eye, and they did not elicit an inflammatory response. In most of the ocular lesions the presence of the parasite could not be demonstrated even by PCR. B1 DNA fragments of T. gondii were detected in only 4 of 11 eyes tested by PCR and Southern blot hybridization. Treatment of mice with MAbs against T cells (CD4 plus CD8) or cytokines (IFN-γ or TNF-α) resulted in a marked increase of ocular lesions, more often associated with the presence of the parasite and the severity of inflammatory response. KW - brain KW - diagnosis KW - disease models KW - experimental infections KW - eyes KW - immune response KW - immunology KW - interferon KW - monoclonal antibodies KW - parasites KW - pathology KW - polymerase chain reaction KW - tumour necrosis factor KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cachectin KW - cachexin KW - cerebrum KW - immunity reactions KW - immunological reactions KW - PCR KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802798&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: differential lysis of two developmental stages of malaria sporozoites by the alternative pathway of complement. AU - Touray, M. G. AU - Seeley, D. C., Jr. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 78 IS - 3 SP - 294 EP - 301 SN - 0014-4894 AD - Touray, M. G.: Laboratory of Malaria Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19940805556. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 9007-36-7. Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology N2 - Whereas 86% of Plasmodium gallinaceum sporozoites from oocysts in Aedes aegypti were lysed when incubated in fresh chicken serum in vitro, only 24% of sporozoites from salivary glands were lysed under identical incubation conditions. Preincubation of oocyst sporozoites in a homogenate of female A. aegypti salivary glands did not diminish their susceptibility to lysis by serum, indicating that lysis was mediated by the interaction of serum factors with parasite-specific molecules. The lytic activity of fresh chicken serum was abrogated by incubating for 45 minutes at 56°C or chelating with EDTA. Fresh chicken serum specifically depleted of Ca2+, by chelating with EGTA in the presence of Mg2+, retained its ability to lyse oocyst sporozoites. The lysis of salivary gland sporozoites mediated by chicken antisporozoite serum was abrogated by EGTA, indicating that the antibody-dependent complement pathway in chicken serum is blocked by EGTA. Because oocyst sporozoite lysis by serum was heat sensitive and Mg2+ dependent, but Ca2+ independent, it is concluded that lysis was mediated by the alternative pathway of complement. KW - complement KW - disease vectors KW - lysis KW - parasites KW - serum KW - sporozoites KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805556&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of two cysteine-rich, lipophilic proteins on the surface of Plasmodium knowlesi ookinetes: Pks20 and Pks24. AU - Fried, M. AU - Gwadz, R. W. AU - Kaslow, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 78 IS - 3 SP - 326 EP - 330 SN - 0014-4894 AD - Fried, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19940805559. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Of 30 MAbs produced using mice immunized 3 times with 4 × 106Plasmodium knowlesi, 25 reacted with the surface of P. knowlesi ookinetes by IFA. 15 culture supernatants from these surface-positive hybridoma cell lines were further characterized by immunoblotting with non-reduced SDS extracts of P. knowlesi ookinetes. 11 culture supernatants reacted with a 24 000 MW protein (Pks24), 3 with a 20 000 MW protein (Pks20), one with an 18 000 MW protein and one to a triplet of proteins of MW about 200 000. Pks24 and Pks20 were shown to be cysteine-rich, lipophilic proteins. Data are presented which suggest that Pks24 and Pks20 are homologues of the family of epidermal growth factor-like transmission-blocking target antigens present in P. falciparum, P. gallinaceum and P. berghei (Pfs25, Pgs25, Pgs28 and Pbs21). KW - monoclonal antibodies KW - ookinetes KW - parasites KW - proteins KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805559&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium: parasite chitinase and its role in malaria transmission. AU - Shahabuddin, M. AU - Kaslow, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 79 IS - 1 SP - 85 EP - 88 SN - 0014-4894 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801682. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 9001-06-3. Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology N2 - This review focuses on Plasmodium chitinase and the role that it plays in the malaria parasite's egress from the bloodmeal in the midgut of the insect vector. The formation of the mosquito peritrophic membrane (PM) is briefly described. It is suggested that to cross the PM the parasite has evolved a zymogen with chitinolytic activity that is activated by mosquito midgut protease. This may allow the parasite to cross the PM more efficiently and in synchrony with the mosquito's physiology. It is suggested that inhibiting these chitinases by chemotherapeutic agents or vaccine-induced antibodies may prove to be potent measures for controlling parasite transmission. KW - chitinase KW - disease transmission KW - disease vectors KW - human diseases KW - parasites KW - peritrophic membrane KW - reviews KW - transmission KW - Anopheles KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodiidae KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Staurosporine inhibits invasion of erythrocytes by malarial merozoites. AU - Ward, G. E. AU - Fujioka, H. AU - Aikawa, M. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1994/// VL - 79 IS - 3 SP - 480 EP - 487 SN - 0014-4894 AD - Ward, G. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803933. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology N2 - Staurosporine, a protein kinase inhibitor, inhibited the invasion of rhesus monkey erythrocytes by Plasmodium knowlesi merozoites with an IC50 of 250 nM. The drug exerted its effects primarily on the merozoite, with little or no effect on the erythrocyte. Okadaic acid, an inhibitor of protein phosphatases, partially abrogated the inhibitory effects of staurosporine. Staurosporine arrested invasion at a step ultrastructurally similar to the arrest caused by cytochalasins B and D: the merozoite attaches, apically reorients, and forms a junction with the erythrocyte, but it does not internalize. It is suggested that protein phosphorylation within the merozoite plays an important role in the internalization step of invasion. KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - invasion KW - merozoites KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium knowlesi KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - blood red cells KW - parasite host relationships KW - red blood cells KW - staurosporine KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803933&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage. AU - Saville, M. W. AU - Taga, K. AU - Foli, A. AU - Broder, S. AU - Tosato, G. AU - Yarchoan, R. JO - Blood JF - Blood Y1 - 1994/// VL - 83 IS - 12 SP - 3591 EP - 3599 SN - 0006-4971 AD - Saville, M. W.: National Cancer Institute, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007112. Publication Type: Journal Article. Language: English. KW - Cells KW - HIV infections KW - Inhibition KW - Macrophages KW - Monocytes KW - Replication KW - human immunodeficiency virus infections KW - Interleukin-10 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007112&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - US dietary patterns associated with fat intake: the 1987 National Health Interview Survey. AU - Subar, A. F. AU - Ziegler, R. G. AU - Patterson, B. H. AU - Ursin, G. AU - Graubard, B. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1994/// VL - 84 IS - 3 SP - 359 EP - 366 SN - 0090-0036 AD - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, Surveillance Program, Applied Research Branch, 9000 Rockville Pike, EPN 313, Bethesda, MD 20892, USA. N1 - Accession Number: 19951403529. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Potatoes N2 - Food frequency data were used to investigate dietary patterns associated with fat intake. Data from the 1987 National Health Interview Survey of 20 143 adults were used in the study. Intakes of vegetables, fruits, cereals, fish/chicken, low-fat milk, alcoholic beverages, vitamin C, percentage of energy from carbohydrates, carotenoids, folate, dietary fibre, carbohydrates and vitamin A decreased as percentage of energy from fat increased. Intakes of salty snacks, peanuts, processed and red meats, whole milk and cheese, dessert, eggs, fried potatoes, table fats, cholesterol, vitamin E, sodium, protein and energy increased with percentage of energy from fat. Results by demographic subgroups showed few differences from those found in the total population. Fat intake is consistently associated with specific dietary patterns. Such patterns need to be evaluated concurrently in studies of diet and chronic disease. KW - diet studies KW - fats KW - food groups KW - intake KW - nutrients KW - nutrition KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403529&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas. AU - Bhatia, K. AU - Spangler, G. AU - Gaidano, G. AU - Hamdy, N. AU - Dalla-Favera, R. AU - Magrath, I. JO - Blood JF - Blood Y1 - 1994/// VL - 84 IS - 3 SP - 883 EP - 888 SN - 0006-4971 AD - Bhatia, K.: Building 10/13c205, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007117. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - genomes KW - Mutations KW - Non-Hodgkin's lymphoma KW - Pathogenesis KW - AIDS KW - C-myc gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary sources of fats and cholesterol in US children aged 2 through 5 years. AU - Thompson, F. E. AU - Dennison, B. A. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1994/// VL - 84 IS - 5 SP - 799 EP - 806 SN - 0090-0036 AD - Thompson, F. E.: National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19951403506. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Dairy Science N2 - A study of lipid intakes among preschool children had 3 objectives: it analysed the contributions of 38 food groups to fat, saturated fat and cholesterol intakes; estimated the effects of food substitutions on intakes; and examined demographic differences in food group intake and food group sources of these lipids. The sample consisted of 547 children, 2 to 5 years old, from the US Department of Agriculture's 1985 and 1986 Continuing Surveys of Food Intakes by Individuals. Dietary information for 4 non-consecutive days throughout a year was used. All foods were classified into groups and the lipids contributed from each group were computed. More than 80% of the children consumed more total fat, saturated fats and cholesterol than is recommended. The major source of total fat and saturated fats was whole milk; the major sources of dietary cholesterol were eggs and whole milk. Children's food consumption patterns differed by region of the country and race/ethnicity, providing opportunities to refine nutrition education interventions and evaluations. By substituting lower-fat foods for the major sources of saturated fats, significant reductions in preschool children's intakes of saturated fats, fat and dietary cholesterol could be achieved. KW - children KW - cholesterol KW - cows KW - diet studies KW - diets KW - fats KW - intake KW - milk KW - milk consumption KW - sources KW - USA KW - cattle KW - man KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) KW - Milk and Dairy Produce (QQ010) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403506&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. AU - Kirnbauer, R. AU - Hubbert, N. L. AU - Wheeler, C. M. AU - Becker, T. M. AU - Lowry, D. R. AU - Schiller, J. T. AU - Galloway, D. A. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 7 SP - 494 EP - 499 SN - 0027-8874 AD - Kirnbauer, R.: (J.T. Schiller) Laboratory of Cellular Oncology, National Cancer Institute, Bldg. 36, Rm 1D19, Bethesda, MD 20892, USA. N1 - Accession Number: 19942027846. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - An ELISA was developed using newly developed HPV16 virus-like particles as antigens to detect anti-HPV16 virion IgG antibodies. These particles are comprised of HPV16 structural proteins that are self-assembled in insect cells after expression by recombinant baculoviruses. The sera of 122 women from New Mexico, USA whose HPV status had been previously evaluated by nucleic acid-based methods, were tested by this ELISA. The sera of 59% of women (32 of 54) positive for genital HPV16 DNA by polymerase chain reaction (PCR) were positive in the ELISA assay compared with sera from women who had tested negative for HPV DNA (P <0.0005). In contrast, 6% of HPV DNA-negative women (two of 31) and 9% of women positive for low-risk HPV 6/11 DNA (one of 11) were ELISA positive by this criterion. The sera of women who were DNA positive for two additional high-risk HPV types were evaluated; the sera of 31% of HPV18-positive (four of 13) and 38% of HPV31-positive women (five of 13) were positive in the HPV16 particle ELISA. The sera of 75% of HPV16 DNA-positive women with severe dysplasias (12 of 16) gave positive ELISA results. The sera of 67% of women (28 of 42) who tested positive for HPV16 DNA by both PCR and the less sensitive ViraType assay tested positive in the ELISA compared with 33% of women (four of 12) who were positive by PCR but negative by ViraType (P <0.05). The authors conclude that the majority of women with cervical HPV16 infection generate an IgG antibody response to conformationally dependent epitopes of HPV16 L1 that can be detected by ELISA. This particular ELISA, or a similar one incorporating virus-like particles of additional HPV types, may be useful in determining the natural history of high-risk HPV infection and perhaps help to identify women at risk for developing cervical cancer. [Denise A. Galloway discusses human papillomavirus capsids as a new approach to identify serological markers of HPV infection in an editorial on p474 of this issue.]From AS KW - diagnosis KW - ELISA KW - infections KW - New Mexico KW - North America KW - USA KW - human papillomaviruses KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Western States of USA KW - Southwestern States of USA KW - Papillomaviridae KW - enzyme linked immunosorbent assay KW - Human papillomavirus KW - Papovaviridae KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027846&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduced risk of esophageal cancer associated with green tea consumption. AU - Gao, Y. T. AU - McLaughlin, J. K. AU - Blot, W. J. AU - Ji, B. T. AU - Dai, Q. AU - Fraumeni, J. F. Jr JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 11 SP - 855 EP - 858 SN - 0027-8874 AD - Gao, Y. T.: (J.K. McLaughlin) National Institutes of Health, Executive Plaza North, Rm. 415G, Rockville, MD 20852, USA. N1 - Accession Number: 19942028225. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases N2 - Medical records of 1016 patients aged 30-74 years old who were diagnosed with oesophageal cancer from October 1, 1990, through January 31, 1993, were identified from the Shanghai Cancer Registry, which covers 6.8 million people in the urban area of Shanghai, China. Patient interviews were then conducted using a structured, standardized questionnaire to obtain information on demographic characteristics, residential history, height and weight, diet, smoking, alcohol and tea drinking, medical history, family history of cancer, occupation, physical activity, and reproductive history. Of the 902 patients interviewed, 734 (81.4%) had their disease pathologically confirmed. There were 1552 control subjects interviewed, including 240 alternates. All analyses of tea effects were conducted separately among men and women and all were adjusted for age. After further adjustment for other known confounders, a protective effect of green tea drinking on oesophageal cancer was observed among women (odds ratio [OR] = 0.50; 95% confidence interval [CI] = 0.30-0.83), and this risk decreased (P for trend ≤0.01) as tea consumption increased. Among men, the ORs were also below 1.00, although not statistically significant. ORs for green tea intake were estimated among those persons who neither smoked nor drank alcohol. In this subset, statistically significant decreases in risk among tea drinkers were observed for both men (OR = 0.43; 95% CI = 0.22-0.86; P for trend = 0.05) and women (OR = 0.40; 95% CI = 0.20-0.77; P for trend <0.001). The authors conclude that this population-based, case-control study of oesophageal cancer in urban Shanghai suggests a protective effect of green tea consumption. Although these findings are consistent with studies in laboratory animals, indicating that green tea can inhibit oesophageal carcinogenesis, further investigations are definitely needed. From AS KW - green tea KW - neoplasms KW - oesophageal cancer KW - oesophagus KW - protection KW - tea KW - Asia KW - China KW - Camellia sinensis KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - esophagus KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028225&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Health claims about vitamin C and cancer. AU - Ziegler, R. G. AU - Byers, T. T2 - Journal of the National Cancer Institute JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 11 SP - 871 EP - 872 SN - 0027-8874 AD - Ziegler, R. G.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Executive Plaza North, Rm 443, Rockville, MD 20852, USA. N1 - Accession Number: 19942028224. Publication Type: Correspondence. Language: English. Registry Number: 50-81-7. Subject Subsets: Tropical Diseases N2 - The correspondents comment on the implications of the negative result from an important intervention trial carried out on 40-69-year-olds from the general population of Linxian, China, a county with extremely high rates of oesophageal and gastric cardia cancer (ibid., 1993, 85, 1483). KW - ascorbic acid KW - failure KW - neoplasms KW - Nutrition KW - oesophagus KW - protection KW - stomach KW - Asia KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancer sites KW - cancers KW - esophagus KW - People's Republic of China KW - vitamin C KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028224&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Temporal patterns in colorectal cancer incidence, survival, and mortality from 1950 through 1990. AU - Chu, K. C. AU - Tarone, R. E. AU - Chow, W. H. AU - Hankey, B. F. AU - Ries, L. A. G. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 13 SP - 997 EP - 1006 SN - 0027-8874 AD - Chu, K. C.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19952002309. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Public Health N2 - Colorectal cancer mortality rates among US white males remained relatively constant from 1950 through 1984 but declined sharply from 1985 through 1990. Those for US white females decreased consistently from 1950 through 1984, with an acceleration of the decline from 1985 through 1990. A study was planned to investigate patterns in incidence, survival, and mortality rates over time in order to examine possible reasons for the gender difference in mortality trends and for the decrease in the slope of the mortality trends for both males and females in the late 1980s. Incidence and survival data from the Connecticut Cancer Registry were examined to investigate the gender differences in mortality rates from 1950 through 1984. Incidence and survival data from the Surveillance, Epidemiology, and End Results (SEER) Programme were investigated to examine reasons for the abrupt downturn in mortality rates for both white males and white females beginning around 1985. During the period 1950 through 1984, the colorectal cancer incidence rates in Connecticut increased for males and declined slightly for females. Survival rates were similar for both sexes, increasing on average over 1% per year for both females and males from 1950 through 1984. Examination of SEER data from 1975 through 1990 revealed that for both males and females there were (1) declines in overall incidence and mortality rates beginning in the mid-1980s, (2) steady declines in distant disease incidence rates since 1975, (3) increases in regional disease incidence rates until the early 1980s followed by declines in the late 1980s, and (4) increases in local disease incidence rates until the mid-1980s followed by declines in the late 1980s. Age-period-cohort analyses of mortality rates indicated a statistically significant moderation of colorectal cancer risk with both advancing birth cohorts and recent calendar periods. The gender differences in colorectal cancer mortality rate trends observed from 1950 through 1984 are due to differences in incidence rate trends between males and females. Declining colorectal mortality rates in the late 1980s for males and females appear to reflect improved early detection. The peaking and subsequent decline of stage-specific incidence rates at later years for successively lower stage indicate sequential stage shifts as cancers are detected increasingly earlier over time. The increased use of sigmoidoscopy and faecal occult blood tests (triggering colonoscopy) appears to have played an important role in reducing colorectal cancer mortality. Improvements in birth cohort trends in risk for colorectal cancer for each sex suggest that lifestyle changes may have also contributed to the steady reductions in colorectal cancer mortality. KW - colon KW - colorectal cancer KW - disease prevalence KW - human diseases KW - mortality KW - neoplasms KW - rectum KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - death rate KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002309&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups. AU - Davis, C. D. AU - Ghoshal, A. AU - Schut, H. A. J. AU - Snyderwine, E. G. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 14 SP - 1065 EP - 1070 SN - 0027-8874 AD - Davis, C. D.: Laboratory of Experimental Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bldg. 37, Room 3C28, Bethesda, MD, USA. N1 - Accession Number: 19951406314. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - To investigate the significance of rat milk as a route of exposure of the neonate to dietary heterocyclic amines, the metabolites of 2-amino-1-methyl-6phenylimidazo(4,5-b)pyridine (PhIP) in rat milk and in urine of nursing pups was examined. Lactating Fischer 344 rats with 5-day-old pups were given a single oral dose of [³H]PhIP 10 mg/kg. Milk was collected from the dams and urine from the pups and then the samples were analysed for metabolites of PhIP, using HPLC. PhIP-DNA adduct values in the tissues of the pups were estimated by 32P-post-labelling analysis. 3 radioactive peaks were observed by HPLC separation of milk samples: an unidentified early eluting peak, 4′-hydroxy-PhIP, and PhIP. 4 metabolites and the parent compound were found in urine of the pups nursed by dams given radiolabelled PhIP: PhIP-4′-O-glucuronide, PhIP-4′-sulfate, 4′-hydroxy-PhIP and N²-hydroxy-PhIP-N³-glucuronide. 4′-Hydroxy-PhIP and its conjugates contributed about 60% of the radioactivity found in the urine. By 32P-post-labelling analysis, PhIP-DNA adducts were detected in spleen, lung, heart, kidney, liver and stomach of pups at mean values ranging from 0.06 to 0.55 adducts/107 nucleotides. The large percentage of 4′-hydroxy-PhIP and its conjugates in the urine indicates that 5-day-old pups detoxify PhIP and further metabolize 4′-hydroxy-PhIP obtained from the rat milk. The presence of the glucuronide conjugate of N-hydroxy-PhIP in the urine of pups and the lack of detectable conjugate or N-hydroxylamine itself in rat milk suggest that PhIP from rat milk undergoes metabolic activation via N-hydroxylation in 5-day-old rat pups. This conclusion was further supported by the observation that hepatic S9 fractions from the pups activated PhIP to a mutagen in the Ames Salmonella mutagenicity assay and by the presence of PhIP-DNA adducts in the tissues of the pups. The findings reported here may have carcinogenic and toxicological implications for the infants of women who breast-feed and consume a diet rich in cooked meat. KW - amines KW - breast feeding KW - carcinogens KW - heterocyclic nitrogen compounds KW - infants KW - lactation KW - metabolism KW - neonates KW - rat milk KW - sucking KW - suckling KW - urine KW - young animals KW - man KW - rats KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - newborn infants KW - rat lactation KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406314&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protein intake and risk of renal cell cancer. AU - Chow, W. H. AU - Gridley, G. AU - McLaughlin, J. K. AU - Mandel, J. S. AU - Wacholder, S. AU - Blot, W. J. AU - Niwa, S. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 15 SP - 1131 EP - 1139 SN - 0027-8874 AD - Chow, W. H.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19951408450. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition N2 - The role of diet in renal cell cancer risk was examined. Subjects (n=690) were white residents of Minnesota, USA, 20 to 79 years old with histologically confirmed renal cell cancer that had been diagnosed between July 1, 1988 and December 31, 1990. 707 sex-, age- and education-matched controls were selected from the general population of Minnesota. Usual adult dietary intakes were assessed by questionnaire and odds ratios were calculated by logistic regression analyses. Increased risks of renal cell cancer were observed with increasing consumption of several food groups, including red meat (P=0.05), high-protein foods (P=0.01) and staple (grains, breads and potatoes) foods (P=0.009). When examined by macronutrient status, risks increased monotonically with amount of protein intake, from 1.2 (95% confidence interval (CI) = 0.7-1.9) to 1.4 (95% CI = 0.8-2.5) and 1.9 (95% CI = 1.0-3.6) (P=0.03) in the second, third and fourth quartiles of intake, respectively, after adjustment for age, sex, energy intake, body mass index and cigarette smoking. No significant or consistent associations were detected with the intake of other dietary nutrients or beverages. Although an independent effect of dietary protein has not been previously associated with renal cell cancer, high protein consumption has been related to development of other chronic renal conditions that may predispose an individual to this cancer. KW - carcinoma KW - diet studies KW - kidneys KW - protein intake KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408450&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer incidence in a population with a high prevalence of infection with human immunodeficiency virus type 1. AU - Rabkin, C. S. AU - Yellin, F. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1994/// VL - 86 IS - 22 SP - 1711 EP - 1716 SN - 0027-8874 AD - Rabkin, C. S.: National Institutes of Health, EPN/434, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001589. Publication Type: Journal Article. Language: English. Number of References: 48 ref. KW - Burkitt's lymphoma KW - epidemiology KW - HIV infections KW - Kaposi's sarcoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001589&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Meeting on parasites and the invertebrate vector. AU - Kaslow, D. C. AU - Nussenzweig, V. AU - Miller, L. JO - Memórias do Instituto Oswaldo Cruz JF - Memórias do Instituto Oswaldo Cruz Y1 - 1994/// VL - 89 IS - 2 SP - 279 EP - 295 SN - 0074-0276 AD - Kaslow, D. C.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950808905. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Registry Number: 9001-67-6. Subject Subsets: Protozoology N2 - A meeting on parasites and their invertebrate vectors, held at the John D. and Catherine T. MacArthur Foundation, USA, from November 18-21 1993, discussed insect defence mechanisms; life cycle transitions; changes in surface molecules during host transition stages; interactions of parasites with host extracellular matrix proteins; insect factors in parasite refractoriness; insect factors in mammalian pathogenesis; molecular approaches to understanding the parasite in the vector; the introduction of genes into vector populations; and identification of opportunities for the future. Included among these major topics are communications on trypanosomal trans-sialidases; lipophosphoglycans of Leishmania; chitinase secretion and Leishmania and Plasmodium; pathogenic protozoa; insect saliva and parasite pathogenicity; and the genetic analysis of trypanosome surface glycoprotein function. KW - biochemistry KW - enzymes KW - genes KW - host parasite relationships KW - immune response KW - life cycle KW - molecular genetics KW - parasites KW - pathogenesis KW - proteins KW - protozoal infections KW - sialidase KW - surface proteins KW - vectors KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - exo-alpha-sialidase KW - immunity reactions KW - immunological reactions KW - membrane proteins KW - neuraminidase KW - parasite host relationships KW - Parasites and the Invertebrate Vector KW - protozoal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808905&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist. AU - Poli, G. AU - Kinter, A. L. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 1 SP - 108 EP - 112 SN - 0027-8424 AD - Poli, G.: Building 10A, Room 6A33A, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028414. Publication Type: Journal Article. Language: English. KW - human immunodeficiency viruses KW - Immunology KW - interleukins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - HUMAN IMMUNODEFICIENCY VIRUS KW - Monocytic cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide. AU - Oswald, I. P. AU - Eltoum, I. AU - Wynn, T. A. AU - Schwartz, B. AU - Caspar, P. AU - Paulin, D. AU - Sher, A. AU - James, S. L. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 3 SP - 999 EP - 1003 SN - 0027-8424 AD - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950808020. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Helminthology N2 - In vitro exposure of murine endothelial cells to various cytokines (interferon γ, tumour necrosis factor α, or interleukin 1α or 1β) resulted in their activation to kill Schistosoma mansoni schistosomula through an arginine-dependent mechanism involving production of nitric oxide (NO). Cytokine-treated endothelial cells showed increased expression of mRNA for the inducible form of the NO synthase, and both NO production and larval killing were suppressed by treatment with competitive inhibitors. The effector function of cytokine-treated endothelial cells was similar to that of activated inflammatory tissue macrophages, although activation appeared to be differentially regulated in these 2 cell types. Activated endothelial cells killed older (18-day) forms, such as those currently thought to be a primary target of immune elimination in the lungs of mice previously vaccinated with radiation-attenuated cercariae, as well as newly transformed larvae. In C57BL/6 mice, which become resistant to S. mansoni infection as a result of vaccination with irradiated cercariae, endothelial cell morphology characteristic of activation was observed in the lung by 1 to 2 weeks after challenge infection. Similar endothelial cell changes were absent in P-strain mice, which do not become resistant as a result of vaccination. It is considered that endothelial cells, not traditionally considered to be part of the immune system, may play an important role in immunity to S. mansoni and, by means of NO-dependent killing, could serve as effectors of resistance to other intravascular pathogens. KW - cytokines KW - helminths KW - immunity KW - interferon KW - interleukin 1 KW - parasites KW - tumour necrosis factor KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - cachectin KW - cachexin KW - endothelial cells KW - parasitic worms KW - Strigeida KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808020&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection. AU - Smythe, J. A. AU - Sun, D. AU - Thomson, M. AU - Markham, P. D. AU - Reitz, M. S. Jr AU - Gallo, R. C. AU - Lisziewicz, J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 9 SP - 3657 EP - 3661 SN - 0027-8424 AD - Smythe, J. A.: (J. Lisziewicz) Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050759. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - gene therapy KW - HIV infections KW - molecular biology KW - prevention KW - treatment KW - AIDS KW - Gag mutants KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050759&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus. AU - Lusso, P. AU - Secchiero, P. AU - Crowley, R. W. AU - Garzino-Demo, A. AU - Berneman, Z. N. AU - Gallo, R. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 9 SP - 3872 EP - 3876 SN - 0027-8424 AD - Lusso, P.: Laboratory of Tumor Cell Biology,Building 37, Room 6A09, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050762. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors show that CD4 is a critical component of the cellular membrane receptor of human herpesvirus type 7. CD4+ cells infected with HHV-7 show selective and progressive downregulation of CD4 expression and monoclonal antibodies against CD4 inhibited the HHV-7 infection. Marked reciprocal interference was seen between HHV-7 and HIV. Persistent infection of cells with HIV or contact with gp120 endowed them with resistance to HHV-7 and exposure of cells to HHV-7 reduced infectability of cells with HIV. Studies are now needed of the influence of active HHV-7 on the course of HIV infection. This appears to be the first time that two unrelated viruses have been shown to share the same receptor on susceptible cells. The authors found that monoclonal antibodies to the V1, V2 and V3 domains but not the V4 domain of CD4 all inhibited HHV-7 infection of cells. HHV-7 was unable to infect productively HeLa cells although it bound to their surface membrane.D. W. FitzSimons KW - CD4 antigens KW - HIV infections KW - human immunodeficiency viruses KW - natural history KW - receptors KW - resistance KW - treatment KW - human herpesvirus 7 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - CD4 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050762&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth. AU - McConkey, G. A. AU - Ittarat, I. AU - Meshnick, S. R. AU - McCutchan, T. F. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 10 SP - 4244 EP - 4248 SN - 0027-8424 AD - McConkey, G. A.: Molecular Biology Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950806977. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 150-13-0. Subject Subsets: Protozoology N2 - Cloned lines of Plasmodium falciparum were isolated that, unlike the parent line from which they were derived, relied on exogenous p-aminobenzoic acid (PABA) for growth. Isolation involved random mutagenesis of a cloned line of P. falciparum and subsequent selection of PABA-dependent parasites. Both parent and PABA-dependent clones were analysed for PABA uptake and synthesis. Each clone took up comparable amounts of PABA from the medium. The parent line, clone 3D7, can synthesize PABA de novo whereas the PABA-dependent clones cannot. The requirement of exogenous PABA for growth by the auxotrophic strains, coupled with their inability to synthesize PABA, indicated that normal parasite growth can be completely supported by either synthesis or salvage. This work further clarified the relationship between the availability of PABA and success of the parasite, an issue of debate from classic studies showing reduced parasite load in individuals on milk-fed diets. KW - growth KW - malaria KW - p-aminobenzoic acid KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - PABA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806977&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. AU - Boyer, P. L. AU - Tantillo, C. AU - Jacobo-Molina, A. AU - Nanni, R. G. AU - Ding, J. AU - Arnold, E. AU - Hughes, S. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 11 SP - 4882 EP - 4886 SN - 0027-8424 AD - Boyer, P. L.: (S. H. Hughes) Advanced BioScience Laboratories-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, PO Box B, Building 539, Frederick MD 21702-1201, USA. N1 - Accession Number: 19942050773. Publication Type: Journal Article. Language: English. Registry Number: 9068-38-6. KW - antiviral agents KW - genomes KW - human immunodeficiency viruses KW - molecular biology KW - nucleotide sequences KW - resistance KW - reverse transcriptase KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA sequences KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050773&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. AU - Burton, J. D. AU - Bamford, R. N. AU - Peters, C. AU - Grant, A. J. AU - Kurys, G. AU - Goldman, C. K. AU - Brennan, J. AU - Roessler, E. AU - Waldmann, T. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 11 SP - 4935 EP - 4939 SN - 0027-8424 AD - Burton, J. D.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008353. Publication Type: Journal Article. Language: English. Number of References: 22 ref. KW - interleukins KW - lymphokines KW - T lymphocytes KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - HTLV-BLV group KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008353&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. AU - Pimenta, P. F. P. AU - Saraiva, E. M. B. AU - Rowton, E. AU - Modi, G. B. AU - Garraway, L. A. AU - Beverley, S. M. AU - Turco, S. J. AU - Sacks, D. L. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 19 SP - 9155 EP - 9159 SN - 0027-8424 AD - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, Immunology and Cell Biology Section, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803018. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Comparison of a large number of phlebotomine vector/Leishmania pairs revealed that species-specific differences in vectorial competence were in every case directly correlated with the ability of promastigotes to attach to the sand-fly midgut, the variable outcomes of which were controlled by structural polymorphisms in the surface lipophosphoglycan (LPG) of the parasite. The ability of Phlebotomus papatasi to transmit only Leishmania major could be attributed to the unique, highly substituted nature of L. major LPG that provides for multiple terminally exposed β-linked galactose residues for binding. While the relatively unsubstituted LPGs of other Leishmania species were unable to mediate promastigote attachment to P. papatasi, they could mediate binding to midguts of P. argentipes, which was found to be a potentially competent vector for every Leishmania species examined. It is suggested that at least some phlebotomine vectors differ with respect to the parasite recognition sites which they express and that midgut adhesion is a sufficiently critical component of vectorial competence as to provide the evolutionary drive for LPG structural polymorphisms. KW - disease vectors KW - lipophosphoglycans KW - parasites KW - vector competence KW - Diptera KW - Leishmania KW - Leishmania major KW - Phlebotominae KW - Phlebotomus KW - Phlebotomus argentipes KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Trypanosomatidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Leishmania KW - Psychodidae KW - Diptera KW - Phlebotominae KW - Phlebotomus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803018&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. AU - Yamanaka, S. AU - Johnson, M. D. AU - Grinberg, A. AU - Westphal, H. AU - Crawley, J. N. AU - Taniike, M. AU - Suzuki, K. AU - Proia, R. L. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 21 SP - 9975 EP - 9979 SN - 0027-8424 AD - Yamanaka, S.: Section on Biochemical Genetics, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950100309. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9027-52-5. Subject Subsets: Agricultural Biotechnology N2 - Tay-Sachs disease, the prototype of the GM2 gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, β-hexosaminidase A. As a consequence of the enzyme deficiency, GM2 ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system (CNS). Rapid mental and motor deterioration starting in the 1st year of life leads to death by 2-4 years of age. Through the targeted disruption of the mouse Hexa gene in embryonic stem cells, mice were produced with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice displayed <1% of normal β-hexosaminidase A activity and accumulated GM2 ganglioside in their CNS in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At 3-5 months of age, the mutant mice showed no apparent defects in motor or memory function. These β-hexosaminidase A-deficient mice should be useful for devising strategies to introduce functional enzyme and genes into the CNS. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease. KW - animal models KW - beta-N-acetylhexosaminidase KW - biotechnology KW - gangliosides KW - homologous recombination KW - targeted mutagenesis KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hexosaminidase KW - Tay-Sachs disease KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Non-communicable Human Diseases and Injuries (VV600) KW - Laboratory Animal Science (LL040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950100309&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful passive and active immunization of cynomolgus monkeys against hepatitis E. AU - Tsarev, S. A. AU - Tsareva, T. S. AU - Emerson, S. U. AU - Govindarajan, S. AU - Shapiro, M. AU - Gerin, J. L. AU - Purcell, R. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 21 SP - 10198 EP - 10202 SN - 0027-8424 AD - Tsarev, S. A.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007023. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health KW - animal models KW - hepatitis E KW - human diseases KW - immunization KW - passive immunization KW - hepatitis E virus KW - man KW - monkeys KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007023&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. AU - Clerici, M. AU - Sarin, A. AU - Coffman, R. L. AU - Wynn, T. A. AU - Blatt, S. P. AU - Hendrix, C. W. AU - Wolf, S. F. AU - Shearer, G. M. AU - Henkart, P. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1994/// VL - 91 IS - 25 SP - 11811 EP - 11815 SN - 0027-8424 AD - Clerici, M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.. N1 - Accession Number: 19952006875. Publication Type: Journal Article. Language: English. Number of References: 30 ref. KW - apoptosis KW - cellular biology KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - interleukins KW - pathogenesis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cell biology KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biology of the development of Plasmodium in the mosquito midgut: a molecular and cellular view. AU - Shahabuddin, M. AU - Kaslow, D. C. JO - Bulletin de l'Institut Pasteur, France JF - Bulletin de l'Institut Pasteur, France Y1 - 1994/// VL - 92 IS - 2 SP - 119 EP - 132 SN - 0020-2452 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950810690. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 64 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The biology of the development of Plasmodium in the mosquito midgut is reviewed from a molecular and cellular viewpoint under the following headings: sporogonic development of Plasmodium in the mosquito vector (emergence from erythrocytes; exflagellation; fertilization; development of zygote to ookinete); the peritrophic matrix; Plasmodium and mosquito PM [peritrophic matrix]. KW - development KW - developmental stages KW - disease vectors KW - life history KW - malaria KW - midgut KW - molecular biology KW - parasites KW - reviews KW - vectors KW - Anopheles KW - Culicidae KW - Diptera KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - growth phase KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950810690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. AU - Castillo, C. AU - Bogardus, C. AU - Bergman, R. AU - Thuillez, P. AU - Lillioja, S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1994/// VL - 93 IS - 1 SP - 10 EP - 16 SN - 0021-9738 AD - Castillo, C.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19951410568. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 50-99-7, 9004-10-8. Subject Subsets: Human Nutrition N2 - Insulin action and obesity are correlated with the density of muscle capillary supply in man. Since the altered muscle anatomy in the obese might affect interstitial insulin concentrations and reduce insulin action, peripheral lymphatic vessels were cannulated in lean and obese men (21.2 to 36.6 years old) and peripheral lymph insulin concentrations were compared with whole body glucose uptake during a euglycaemic, hyperinsulinaemic clamp. Lymph insulin concentrations in the lower limb averaged only 34% of arterial insulin concentrations during 150 min of insulin infusion. Obese subjects had the highest arterial (P≤0.0001) and lymph insulin (P<0.005) concentrations, but the lowest glucose uptake rates (P<0.002). In contrast to the initial steep increase then plateau of arterial insulins, lymph insulin and whole body glucose uptake rates increased slowly and did not consistently reach a plateau. In each individual, the glucose uptake closely correlated with peripheral lymphatic insulin concentrations (mean r² = 0.95). The coupling between glucose uptake and lymph insulin (glucose uptake/pmol insulin) was much steeper in lean subjects than in the obese (P≤0.0001). These results indicate that even if insulin diffusion into tissues is rate limiting for insulin action, a tissue defect rather than an insulin diffusion defect causes insulin resistance in obese subjects. KW - glucose KW - insulin KW - lymph KW - men KW - obesity KW - uptake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dextrose KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. AU - Rader, D. J. AU - Cain, W. AU - Ikewaki, K. AU - Talley, G. AU - Zech, L. A. AU - Usher, D. AU - Brewer, H. B., Jr. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1994/// VL - 93 IS - 6 SP - 2758 EP - 2763 SN - 0021-9738 AD - Rader, D. J.: Molecular Disease Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951408107. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - Lipoprotein(a) (Lp[a]) is an atherogenic lipoprotein which is similar in structure to LDL but contains an additional protein called apolipoprotein(a) (apo[a]). Apo(a) is highly polymorphic in size, and there is a strong inverse association between the size of the apo(a) isoform and the plasma concentration of Lp(a). In vivo catabolism of Lp(a) particles containing different size apo(a) isoforms were compared to establish whether there is an effect of apo(a) isoform size on the catabolic rate of Lp(a). In the first series of studies, 4 normal subjects were injected with radiolabelled S1-Lp(a) and S2-Lp(a) and another 4 were injected with radiolabelled S2-Lp(a) and S4-Lp(a). No significant differences in fractional catabolic rate were found between Lp(a) particles containing different apo(a) isoforms. To confirm that apo(a) isoform size does not influence the rate of Lp(a) catabolism, 3 subjects heterozygous for apo(a) were selected for preparative isolation of both Lp(a) particles. The first was a B/S3-apo(a) subject, the second a S4/S6-apo(a) subject and the third an F/S3-apo(a) subject. From each subject, both Lp(a) particles were preparatively isolated, radiolabelled and injected into donor subjects and normal volunteers. In all cases, the catabolic rates of the 2 forms of Lp(a) were not significantly different. In contrast, the allele-specific apo(a) production rates were more than twice as great for the smaller apo(a) isoforms than for the larger apo(a) isoforms. In 17 studies directly comparing Lp(a) particles of different apo(a) isoform size, the mean fractional catabolic rate of the Lp(a) with smaller size apo(a) was 0.329±0.090 day-1 and of the Lp(a) with the larger size apo(a) 0.306±0.079 day-1, not significantly different. In summary, the inverse association of plasma Lp(a) concentrations with apo(a) isoform size is not due to differences in the catabolic rates of Lp(a) but rather to differences in Lp(a) production rates. KW - apolipoproteins KW - blood KW - catabolism KW - kinetics KW - lipid metabolism KW - lipoproteins KW - metabolism KW - size KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fat metabolism KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408107&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lipid levels in adults with cystic fibrosis. AU - Slesinski, M. J. AU - Gloninger, M. F. AU - Costantino, J. P. AU - Orenstein, D. M. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1994/// VL - 94 IS - 4 SP - 402 EP - 408 SN - 0002-8223 AD - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951401402. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The hypothesis that an energy-dense, high-fat diet, which is necessary to maintain weight in adults with cystic fibrosis, does not result in high serum cholesterol concentrations was tested. Dietary, anthropometric and biochemical data from 31 adults with cystic fibrosis, 50 obligate carriers of the cystic fibrosis gene, and 26 controls who did not have cystic fibrosis were correlated at a cystic fibrosis centre in Pittsburgh, USA. Adults with cystic fibrosis had a lower mean serum cholesterol concentration and higher mean intakes of energy and fat than controls. Univariate correlation coefficients were estimated to measure the relative intensity of association between 2 variables. Mean total serum cholesterol concentrations in men with cystic fibrosis and male controls was 3.1 and 4.7 mmol/litre, respectively (P<0.001). Mean total serum cholesterol concentrations in women with cystic fibrosis was 3.2 compared with 4.3 mmol/litre in female controls (P<0.001). 3 adults with cystic fibrosis and no signs of pancreatic insufficiency had serum cholesterol concentrations in the high normal range. Carriers had serum lipid concentrations in the same range as controls. The findings indicate that a high-energy, high-fat diet does not increase serum lipid concentrations in those patients with cystic fibrosis and pancreatic insufficiency. However, those individuals with cystic fibrosis and normal pancreatic function may be at the same risk as the general population for developing high serum lipid concentrations. They should have their serum lipid concentrations monitored and be given appropriate dietary recommendations. KW - adults KW - blood lipids KW - cholesterol KW - cystic fibrosis KW - diet treatment KW - energy intake KW - fats KW - intake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - diet prescription KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor: a novel strategy for the therapy of KS. AU - Ensoli, B. AU - Markham, P. AU - Kao, V. AU - Barillari, G. AU - Fiorelli, V. AU - Gendelman, R. AU - Raffeld, M. AU - Zon, G. AU - Gallo, R. C. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1994/// VL - 94 IS - 5 SP - 1736 EP - 1746 SN - 0021-9738 AD - Ensoli, B.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6A09, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001599. Publication Type: Journal Article. Language: English. Number of References: 39 ref. KW - acquired immune deficiency syndrome KW - angiogenesis KW - human diseases KW - inhibition KW - Kaposi's sarcoma KW - pathogenesis KW - treatment KW - AIDS KW - antisense oligonucleotides KW - fibroblast growth factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001599&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional prediction of pressure ulcers. AU - Breslow, R. A. AU - Bergstrom, N. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1994/// VL - 94 IS - 11 SP - 1301 EP - 1304 SN - 0002-8223 AD - Breslow, R. A.: National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA. N1 - Accession Number: 19951402287. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - This article focuses on nutritional risk factors that predict the development of pressure ulcers in hospital and nursing home patients. Cross-sectional studies associate inadequate energy and protein intake; underweight; low triceps skinfold measurement; and low serum albumin, serum cholesterol and haemoglobin values with pressure ulcers. Prospective studies identify inadequate energy and protein intake, a poor score on the Braden scale (a risk assessment instrument that includes a nutrition component) and possibly low serum albumin as risk factors for developing a pressure ulcer. Nutritionists should provide a high-energy, high-protein diet for patients at risk of development of pressure ulcers to improve their dietary intake and nutritional state. KW - anthropometric dimensions KW - blood KW - cholesterol KW - diet KW - energy intake KW - haemoglobin KW - nutritional state KW - protein intake KW - risk KW - serum albumin KW - ulcers KW - underweight KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anthropometric measurements KW - hemoglobin KW - nutritional status KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402287&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gravidity, obesity,and non-insulin-dependent diabetes among Pima Indian women. AU - Charles, M. A. AU - Pettitt, D. J. AU - McCance, D. R. AU - Hanson, R. L. AU - Bennett, P. H. AU - Knowler, W. C. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1994/// VL - 97 IS - 3 SP - 250 EP - 255 SN - 0002-9343 AD - Charles, M. A.: National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, Arizona 85014, USA. N1 - Accession Number: 19951407790. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - A study was conducted to evaluate the relationship among gravidity, obesity and non-insulin-dependent diabetes mellitus (NIDDM) in 2779 Pima Indian women. Prevalence of NIDDM was higher among women who had never been pregnant than among those who had been pregnant (age- and obesity-adjusted odds ratio = 2.0; 95% confidence interval (CI) = 1.5 to 2.7). Controlled for age and obesity, nondiabetic women who had never been pregnant had higher fasting plasma glucose concentrations by 2% (P=0.004), higher fasting serum insulin concentrations by 8% (P=0.09) and higher 2-h serum insulin concentrations by 10% (P=0.07) than nondiabetic women who had been pregnant. Among 1025 women observed for an average of 8 years, those who had not been pregnant by the baseline examination were at significantly higher risk for developing NIDDM before 40 years old (incidence rate ratio = 1.5; 95% CI = 1.2 to 2.1), but that difference could be accounted for by a higher degree of obesity. It is hypothesized that Pima Indian women who have a high risk for NIDDM develop obesity and hyperinsulinaemia at an early age, and that may be responsible for decreased fertility because of associated changes in sex hormones. KW - diabetes KW - ethnic groups KW - fertility KW - obesity KW - pregnancy KW - risk KW - risk factors KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - gestation KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407790&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NO as an effector molecule of parasite killing: modulation of its synthesis by cytokines. AU - Oswald, I. P. AU - Wynn, T. A. AU - Sher, A. AU - James, S. L. JO - Comparative Biochemistry and Physiology. C, Pharmacology, Toxicology & Endocrinology JF - Comparative Biochemistry and Physiology. C, Pharmacology, Toxicology & Endocrinology Y1 - 1994/// VL - 108 IS - 1 SP - 11 EP - 18 SN - 0742-8413 AD - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801247. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 76057-06-2, 9008-11-1, 10102-43-9. Subject Subsets: Protozoology; Helminthology N2 - This review considers the role of nitric oxide (NO) as a major effector molecule of macrophage cytotoxicity against a variety of microbial targets, including protozoan and helminth parasites. NO production by macrophages is arginine dependent and catalyzed by a cytokine-inducible form of the NO synthase. This activity is positively controlled by several up-regulatory stimuli (including interferon-γ, tumour necrosis factor-α and interleukin (IL)-2) and negatively controlled by others (principally IL-10, IL-4 and transforming growth factor-β). Other cell types, such as endothelial cells and hepatocytes, display a similar capacity for NO production in response to cytokine stimulation. In murine models of leishmaniasis and schistosomiasis, in vivo NO synthesis correlates with protective immunity against infection. KW - cytokines KW - endothelium KW - helminths KW - immune response KW - interferon KW - interleukins KW - liver cells KW - macrophages KW - nitric oxide KW - parasites KW - reviews KW - transforming growth factor KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - hepatocytes KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801247&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of the lipophosphoglycan of Leishmania in vector competence. AU - Sacks, D. L. AU - Saraiva, E. M. AU - Rowton, E. AU - Turco, S. J. AU - Pimenta, P. F. A2 - Smith, J. E. A2 - Chappell, L. H. JO - Parasitology JF - Parasitology Y1 - 1994/// VL - 108 SP - S55 EP - S62 SN - 0031-1820 AD - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800683. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 42 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The surface lipophosphoglycans (LPG) of Leishmania promastigotes express stage- and species-specific polymorphisms that are defined by variations in the type and number of phosphorylated oligosaccharide repeats. The way in which these polymorphic structures control the development of transmissible infections in the sandfly vector as well as the species-specificity of vectorial competence was studied in Phlebotomus papatasi, P. argentipes and Lutzomyia longipalpis. Procyclic promastigotes displayed an inherent capacity to bind to midgut epithelial cells of a competent vector. This capacity was lost during their transformation to metacyclic promastigotes, permitting the selective release and anterior migration of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release were found to be controlled by developmental modifications in terminally exposed saccharides on LPG, which, depending on the species of Leishmania, involved either substitution or capping of terminal side-chain sugars, loss of terminal side-chain sugars, substitution or loss of neutral capping sugars. The stage-specific terminal sugars involved in midgut adhesion are, in some cases, also species-specific, and the extent to which these differences affect midgut attachment, forcefully predicted vectorial competence. KW - disease vectors KW - host parasite relationships KW - human diseases KW - leishmaniasis KW - lipophosphoglycans KW - parasites KW - promastigotes KW - vector competence KW - vector-borne diseases KW - Diptera KW - Leishmania KW - Lutzomyia longipalpis KW - Phlebotominae KW - Phlebotomus argentipes KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Trypanosomatidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Lutzomyia KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Phlebotomus KW - leishmaniosis KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800683&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Misdiagnosed HIV infection in pregnant women: implications for clinical care. AU - Sheon, A. R. AU - Fox, H. E. AU - Alexander, G. AU - Buck, A. AU - Higgins, A. AU - McDermott, S. M. AU - Moroso, G. AU - Moye, J. AU - Pacheco-Acosta, E. JO - Public Health Reports JF - Public Health Reports Y1 - 1994/// VL - 109 IS - 5 SP - 694 EP - 699 SN - 0033-3549 AD - Sheon, A. R.: Divison of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Rockville, MD 20892, USA. N1 - Accession Number: 19952001094. Publication Type: Journal Article. Language: English. Number of References: 27 ref. KW - antibody testing KW - HIV infections KW - human diseases KW - maternal transmission KW - misdiagnosis KW - pregnancy KW - serology KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antibody detection KW - antibody tests KW - gestation KW - human immunodeficiency virus infections KW - mother to child transmission KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001094&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Social and legal factors related to drug abuse in the United States and Japan. AU - Greberman, S. B. AU - Wada, K. JO - Public Health Reports JF - Public Health Reports Y1 - 1994/// VL - 109 IS - 6 SP - 731 EP - 737 SN - 0033-3549 AD - Greberman, S. B.: National Institute on Drug Abuse Addiction Research Center, Treatment Branch, P.O. Box 5180, Baltimore, MD 21224, USA. N1 - Accession Number: 19952010526. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - An overview. KW - drug abuse KW - human diseases KW - law KW - reviews KW - sociology KW - Asia KW - Japan KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - America KW - North America KW - drug use KW - legal aspects KW - legal principles KW - social aspects KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Laws and Regulations (DD500) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010526&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Postoperative complications in patients receiving suramin therapy. AU - Cole, D. AU - Ettinghausen, S. E. AU - Pass, H. I. AU - Danforth, D. N. AU - Linehan, M. W. AU - Myers, C. W. AU - Cooper, M. R. AU - Sindelar, W. F. JO - Surgery JF - Surgery Y1 - 1994/// VL - 116 IS - 1 SP - 90 EP - 95 SN - 0039-6060 AD - Cole, D.: Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10 Room 2B42, Bethesda, MD 20892, USA. N1 - Accession Number: 19940804357. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 145-63-1. Subject Subsets: Protozoology; Helminthology KW - adverse effects KW - antiprotozoal agents KW - helminths KW - parasites KW - suramin KW - surgery KW - toxicity KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - adverse reactions KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Diagnosis of ocular toxoplasmosis by the use of immunocytology and the polymerase chain reaction. AU - Chan, C. C. AU - Palestine, A. G. AU - Li, Q. AU - Nussenblatt, R. B. T2 - American Journal of Ophthalmology JO - American Journal of Ophthalmology JF - American Journal of Ophthalmology Y1 - 1994/// VL - 117 IS - 6 SP - 803 EP - 805 SN - 0002-9394 AD - Chan, C. C.: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805019. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology N2 - The use of polymerase chain reaction (PCR), for amplification of the 35-fold repetitive B1 gene of Toxoplasma gondii, in the diagnosis of ocular toxoplasmosis is reported. A 61-year-old man with an 18 year history of chronic lymphocytic leukaemia presented with deterioration of vision in the left eye. Routine investigations failed to find a convincing cause of his retinitis. A diagnostic vitrectomy was performed and PCR identified T. gondii. Subsequent post mortem examination provided further material and, using PCR, only sections through the ocular lesion were positive for T. gondii. In this patient, the phenotype of the infiltrating cells found in the left eye proved critical for the diagnosis and to help guide therapy. KW - case reports KW - human diseases KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - retinitis KW - toxoplasmosis KW - USA KW - Apicomplexa KW - man KW - protozoa KW - Sarcocystidae KW - Toxoplasma gondii KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Eucoccidiorida KW - Apicomplexa KW - Toxoplasma KW - Sarcocystidae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nucleotide sequence and analysis of the gene in Borrelia burgdorferi encoding the immunogenic P39 antigen. AU - Simpson, W. J. AU - Cieplak, W. AU - Schrumpf, M. E. AU - Barbour, A. G. AU - Schwan, T. G. JO - FEMS Microbiology Letters JF - FEMS Microbiology Letters Y1 - 1994/// VL - 119 IS - 3 SP - 381 EP - 388 SN - 0378-1097 AD - Simpson, W. J.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19960500232. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The P39 antigen is a specific, highly conserved and immunogenic protein of B. burgdorferi s.l. The nucleotide sequence of the gene encoding this protein was determined and found to be the first of 2 tandemly arranged open reading frames (ORFs) located on the spirochaete's chromosome. These 2 ORFs were designated bmpA for the gene encoding P39 and bmpB for the gene encoding the putative protein ORF2 encoded by the 2nd ORF. The nucleic acid sequence identity for the 2 ORFs was 62%, while their deduced amino acid sequences were 52% identical. Comparison to sequence databases demonstrated that the deduced amino acid sequences of both P39 and ORF2 were homologous to TmpC, a putative outer or cytoplasmic lipoprotein of Treponema pallidum. KW - amino acid sequences KW - genes KW - molecular genetics KW - nucleotide sequences KW - proteins KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - DNA sequences KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats. AU - Davis, C. D. AU - Farb, A. AU - Thorgeirsson, S. S. AU - Virmani, R. AU - Synderwine, E. G. JO - Toxicology and Applied Pharmacology JF - Toxicology and Applied Pharmacology Y1 - 1994/// VL - 124 IS - 2 SP - 201 EP - 211 SN - 0041-008X AD - Davis, C. D.: Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19941405664. Publication Type: Journal Article. Language: English. Number of References: 37 refs. Subject Subsets: Human Nutrition N2 - Cooked meat contains a number of mutagenic/carcinogenic heterocyclic amines, including 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP). Monkeys treated with IQ show myocyte degeneration and mitochondrial changes. To develop models to investigate heterocyclic amine cardiotoxicity, primary cultures of foetal rat myocytes were exposed to the activated forms of the carcinogens (N-OH-IQ and N-OH-PhIP). Lactate dehydrogenase leakage increased in proportion to carcinogen dose but was significantly greater in cells exposed to N-OH-IQ than that in cells exposed to N-OH-PhIP. Electron microscopy revealed that treated cells had swollen and irregular mitochondria and fewer organelles. However, DNA adducts, assessed using the 32P-postlabelling method, were significantly higher in myocytes exposed to N-OH-PhIP than in cells exposed to N-OH-IQ. The toxic effects of heterocyclic amines were also evaluated in rats given IQ or PhIP (100 mg/kg, by mouth 10 doses during 2 weeks). Light microscopic and ultra-structural cardiac abnormalities were present in 7 of 8 rats exposed to IQ or PhIP. Whereas controls had a normal cardiac morphology, carcinogen-treated rats had foci of chronic inflammation with myocyte necrosis, myofibrillar dissolution and disarray, and dilation of T-tubules. The results suggest that, in addition to be carcinogenic, food mutagens may play a role in cardiac degeneration. KW - amines KW - cell cultures KW - foods KW - heart KW - heterocyclic nitrogen compounds KW - muscles KW - mutagenesis KW - mutagenicity KW - mutagens KW - toxicity KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405664&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determination of fractional absorption of dietary calcium in humans. AU - Yergey, A. L. AU - Abrams, S. A. AU - Vieira, N. E. AU - Aldroubi, A. AU - Marini, J. AU - Sidbury, J. B. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1994/// VL - 124 IS - 5 SP - 674 EP - 682 SN - 0022-3166 AD - Yergey, A. L.: National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19941407064. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition N2 - 4 dual-isotopic label methods for estimating true fractional absorption of dietary calcium were compared in normal subjects (including pregnant and lactating women and children), adults with osteoporosis secondary to glycogen storage disease and patients with osteogenesis imperfecta. The ratio of the integrals of oral label in a 24-h pooled urine to intravenous label in the same urine (α24h) was taken as the standard against which the others were compared. αSpot was the ratio of the fraction of oral label to the fraction of intravenous label in a single urine specimen; αLag was the ratio of the value of oral label in blood 4 h after administration to the value of intravenous label in blood 2 h after administration. αDec was obtained by deconvoluting response to the intravenous label from the response to the oral tracer. Results were as follows: α24h = 0.273±0.124, αDec = 0.300±0.101 (n=14), αSpot = 0.359±0.179 and αLag = 0.271±0.103. The Bland-Altman approach for comparison of methods was used to show that results for αSpot and αLag can be expected, with a 95% confidence limit, to differ from the value of α24h by 60 and 69%, respectively. The results for αDec were shown to be not only indistinguishable from α24h but identical from a theoretical perspective. KW - bone diseases KW - bone formation KW - calcium absorption KW - comparisons KW - estimation KW - glycogenosis KW - isotopes KW - metabolic disorders KW - methodology KW - osteogenesis imperfecta KW - osteoporosis KW - tracer techniques KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bone calcification KW - brittle bone disease KW - glycogen disease KW - glycogen storage disease KW - glycogenic hepatomegaly KW - metabolic diseases KW - methods KW - Pompe's disease KW - Von Gierke's disease KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Chemistry (ZZ600) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407064&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary assessment resource manual. AU - Thompson, F. E. AU - Byers, T. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1994/// VL - 124 IS - 11, SUP SP - 2245S EP - 2317S SN - 0022-3166 AD - Thompson, F. E.: National Cancer Institute, Division of Cancer Prevention and Control, Applied Research Branch, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19951400129. Publication Type: Journal Article. Language: English. Number of References: 234 ref. Subject Subsets: Human Nutrition N2 - This manual is intended to help nutritionists and others involved in assessing diet. It provides a brief description and critical evaluation of common dietary assessment methods, advice on choosing the most appropriate method for various designs, a discussion of issues to be considered when assessing diet, examples of specific assessment tools and a list of reviews and publications on dietary assessments. KW - assessment KW - diet KW - diet study techniques KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400129&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gianotti-Crosti syndrome and human immunodeficiency virus infection. AU - Blauvelt, A. AU - Turner, M. L. JO - Archives of Dermatology JF - Archives of Dermatology Y1 - 1994/// VL - 130 IS - 4 SP - 481 EP - 483 SN - 0003-987X AD - Blauvelt, A.: (M.L. Turner) Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006225. Publication Type: Journal Article. Language: English. KW - Children KW - Dermatology KW - Hepatitis C KW - HIV infections KW - lesions KW - skin KW - skin lesions KW - Cytomegalovirus KW - man KW - Mycobacterium KW - Mycobacterium avium complex KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - bacterium KW - dermis KW - Gianotti-Crosti syndrome KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006225&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for an in vivo role of insulin-like growth factor-binding protein-1 and -2 as inhibitors of collagen gene expression in vitamin C-deficient and fasted guinea pigs. AU - Gosiewska, A. AU - Wilson, S. AU - Kwon, D. AU - Peterkofsky, B. JO - Endocrinology (Philadelphia) JF - Endocrinology (Philadelphia) Y1 - 1994/// VL - 134 IS - 3 SP - 1329 EP - 1339 SN - 0013-7227 AD - Gosiewska, A.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19941412483. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 50-81-7, 61912-98-9. Subject Subsets: Human Nutrition N2 - The kinetics of induction of insulin-like growth factor-binding protein-1 and -2 (IGFBP-1 and -2) relative to suppression of collagen gene expression was investigated. Guinea pigs were fasted for 10 to 96 h, with 3 to 24% weight loss, or received an ascorbate-free diet for up to 4 weeks, with 5 to 28% weight loss during the third and fourth weeks (phase II of scurvy). In both deficiencies, there was noncoordinate regulation of collagen mRNA expression in tissues. Type I collagen mRNA concentrations in skin decreased rapidly after 5 to 10% weight loss and reached about 10% of normal values, whereas in bone, there was a later, and not as extensive, decrease. The concentration of cartilage type II collagen mRNA decreased rapidly initially, but then remained at 40 to 50% of normal. Circulating insulin-like growth factor I (IGF-I) concentrations remained normal during the period when collagen gene expression was initially suppressed, although there was a later decrease. In contrast, mRNAs for IGFBP-1 and -2 and the circulating proteins were induced before or concomitantly with the suppression of collagen gene expression. The ability of fasted or scorbutic guinea pig sera to inhibit IGF-I action in cells increased in parallel with IGFBP activity ([125I]IGF-I binding), which, in turn, mainly reflected the concentration of IGFBP-1 in sera. Serum insulin may be the primary regulator of the IGFBPs. Its values were decreased to 10 to 13% of normal when weight loss commenced, whereas cortisol values, although increased, did not correlate with the induction of IGFBPs. The overall results taken together with recent findings from cell culture experiments are compatible with circulating IGFBP-1 and -2 acting as inhibitors of collagen gene expression by blocking IGF-I action during fasting and phase II of vitamin C deficiency. KW - ascorbic acid KW - binding proteins KW - collagen KW - deficiency KW - gene expression KW - inhibition KW - insulin-like growth factor KW - vitamins KW - guineapigs KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - guinea pigs KW - somatomedin C KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412483&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy adjustment methods for nutritional epidemiology: the effect of categorization. AU - Brown, C. C. AU - Kipnis, V. AU - Freedman, L. S. AU - Hartman, A. M. AU - Schatzkin, A. AU - Wacholder, S. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1994/// VL - 139 IS - 3 SP - 323 EP - 338 SN - 0002-9262 AD - Brown, C. C.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951400966. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition N2 - The interpretation of 4 alternative energy adjustment methods (Residual, Standard, Partition and Nutrient Density) that have been proposed for the analysis of nutritional epidemiology studies was examined. These methods have so far been compared under circumstances where intake of the nutrient of interest is measured as a continuous variable. Because it is common practice to categorize nutrient intakes in the analysis, the authors investigate the effect of such categorization on the interpretation of results from the 4 methods with the use of computer simulations and statistical theory. They consider 4 cases: where the nutrient intake is divided into quartiles or ordered so as to investigate trend over the quartile groups, combined with using an adjusting variable that is continuous or categorized. The results show: Residual, Standard and Partition methods are no longer equivalent as they are in the continuous case; compared with the Standard method, the Residual method appears to be more powerful for detecting trends in relative odds, is more robust to residual confounding when the adjustment variable is categorized, and provides more meaningful odds ratios; and the Residual and Nutrient Density methods give closely similar results. KW - assessment KW - diet study techniques KW - epidemiology KW - methodology KW - models KW - nutrition KW - statistics KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - methods KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400966&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome. AU - Biggar, R. J. AU - Curtis, R. E. AU - Cote, T. R. AU - Rabkin, C. S. AU - Melbye, M. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1994/// VL - 139 IS - 4 SP - 362 EP - 368 SN - 0002-9262 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19942006081. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - HIV infections KW - Kaposi's sarcoma KW - Neoplasms KW - Non-Hodgkin's lymphoma KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - cancers KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006081&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Physical activity and risk of breast cancer in the Framingham Heart Study. AU - Dorgan, J. F. AU - Brown, C. AU - et al. AU - Barrett, M. ( JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1994/// VL - 139 IS - 7 SP - 662 EP - 669 SN - 0002-9262 AD - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, EPN, Room 211, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19942028515. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors analysed data from the Framingham Heart Study [in the USA] to evaluate the association between physical activity and breast cancer risk. Physical activity was ascertained by a physician-administered questionnaire from 2321 women at the fourth biennial examination conducted in 1954-1956. Breast cancers were identified by self-report, surveillance of admissions to Framingham Union Hospital, and review of death records; all but one were histologically confirmed. During 28 years of follow-up, 117 breast cancer cases were diagnosed among the 2307 women with data on physical activity and reproductive history (a potential confounder). Analysis was performed using Cox proportional hazards models with age as the underlying time variable. Models were adjusted for age at physical activity assessment, menopausal status, age at first pregnancy, parity, education, occupation, and alcohol ingestion. [The authors] observed a gradient of increasing risk of breast cancer with increasing physical activity (trend P = 0.06). The relative risk for women in the highest vs. lowest activity quartile was 1.6 (95% confidence interval 0.9-3.0; P = 0.13). Although both moderate-to-heavy leisure and occupational activities were associated with an increased risk, the association was marginally significant only for leisure activity (P = 0.06). [The authors'] findings do not support a protective effect of physical activity during adulthood for breast cancer, but suggest an increased risk among more active women.AS KW - breast KW - neoplasms KW - physical activity KW - risk factors KW - North America KW - USA KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028515&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of the electrophoretic karyotypes and chromosomal location of ten genes in the two varieties of Cryptococcus neoformans. AU - Wickes, B. L. AU - Moore, T. D. E. AU - Kwon-Chung, K. J. JO - Microbiology (Reading) JF - Microbiology (Reading) Y1 - 1994/// VL - 140 IS - 3 SP - 543 EP - 550 SN - 1350-0872 AD - Wickes, B. L.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201196. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Multiple isolates of C. neoformans var. neoformans and C. neoformans var. gattii, as well as previously characterized representative isolates, were compared for their electrophoretic karyotypes using pulsed-field electrophoresis. The 2 varieties could be clearly distinguished based upon the size of the smallest chromosome. The smallest chromosome for isolates of the gattii variety (serotypes B and C) was 400-700 kb in size. The smallest chromosome for isolates of the neoformans variety was consistently larger, approx. 770 kb in size. Isolates of the gattii variety averaged 13 chromosomes while the neoformans variety averaged 12. The size of the Cryptococcus genome was approx. 23 megabases. With regard to gene position, isolates of C. neoformans var. neoformans tended to be more conserved than those of var. gattii. KW - electrophoresis KW - genetics KW - karyotypes KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus neoformans KW - Cryptococcus neoformans var. gattii KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201196&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Maternal smoking during lactation: relation to infant size at one year of age. AU - Little, R. E. AU - Lambert, M. D., III AU - Worthington-Roberts, B. AU - Ervin, C. H. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1994/// VL - 140 IS - 6 SP - 544 EP - 554 SN - 0002-9262 AD - Little, R. E.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. N1 - Accession Number: 19950400489. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - This study was conducted to test the hypothesis that breast-fed infants of smokers are smaller in size at 1 year of age than breast-fed infants of non-smokers. Three groups of infants were selected from all singletons born to women who were seen for prenatal care in their 6th month of pregnancy at a health maintenance organization in Seattle, Washington, USA, between Jan. 1982 and April 1983. Breast-fed infants of smokers (n = 74) were compared with breast-fed infants of non-smokers (n = 195) and with bottle-fed infants of smokers (n = 64). Mothers were interviewed at 1 and 3 months after delivery; both the mother and the infant were seen at 1 year. Among breast feeders, smokers' infants were twice as likely as non-smokers' infants to have body weight >1 s.d. above the mean (relative risk = 2.04, 95% confidence interval 1.15-3.61). This relationship persisted after control for gestational age and weight at birth, length of lactation, mother's size and diet, exposure to other drugs in human milk, and all other variables measured in this study. Every 10 cigarettes smoked while breast-feeding predicted an additional 3% infant body weight at 1 year. In summary, breast-fed infants of smokers in this study gained more weight after birth than the other 2 groups; at 1 year of age, they were heavier and had significantly higher body weight. KW - body weight KW - breast feeding KW - growth KW - infants KW - lactation KW - liveweight gain KW - tobacco smoking KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human lactation KW - liveweight gains KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400489&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Moderate low birth weight and infectious disease mortality during infancy and childhood. AU - Read, J. S. AU - Clemens, J. D. AU - Klebanoff, M. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1994/// VL - 140 IS - 8 SP - 721 EP - 733 SN - 0002-9262 AD - Read, J. S.: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 19952001489. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health N2 - The purpose of this study was to determine whether moderately low birth weight, singleton babies without congenital anomalies are at increased risk for postperinatal infectious disease mortality. The study cohort consisted of 54 795 live births assembled at 12 medical school-affiliated hospitals in different regions of the United States between 1959 and 1966 and followed prospectively. After exclusions of multiple gestation births, very low birth weight (less than 1500 g) births, births with major congenital anomalies, and first-week deaths, 51 931 children remained for analysis. Postperinatal infectious disease mortality was assessed through age 7 years. Causes of death were classified independently by two pediatricians, blinded to birth weight status, according to an algorithm developed for the study. Moderately low birth weight infants and children were at increased risk of infectious disease mortality (relative risk (RR) = 2.49, 95% confidence interval (CI) 1.74-3.55). The risk persisted among those whose deaths met the authors' strictest criteria for infectious aetiology and was sustained beyond infancy throughout the age interval under analysis. Among those with moderate low birth weight, there was an increased risk among those with preterm birth (RR = 2.77, 95% CI 1.19-6.46) but not among those who were born small-for-gestational age (RR = 1.19, 95% CI 0.37-3.83). The data suggest that moderate low birth weight renders individuals vulnerable to infectious disease mortality during both infancy and childhood. Among moderately low birth weight infants and children, this vulnerability appeared to be attributable primarily to preterm birth rather than to intrauterine growth retardation. KW - birth weight KW - children KW - human diseases KW - infant mortality KW - infants KW - infectious diseases KW - low birth weight infants KW - mortality KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - communicable diseases KW - death rate KW - United States of America KW - Demography (UU200) KW - Human Fertility (UU250) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001489&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. AU - Margolis, N. AU - Hogan, D. AU - Cieplak, W., Jr. AU - Schwan, T. G. AU - Rosa, P. A. JO - Gene JF - Gene Y1 - 1994/// VL - 143 IS - 1 SP - 105 EP - 110 SN - 0378-1119 AD - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950504927. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Synthesis of the B. burgdorferi outer surface protein C (OspC) is quite variable. The ospC gene from B. burgdorferi isolate CA-11.2A, a clone in which ospC expression varies, was cloned and sequenced. The 5' flanking region of the gene contains at least 2 consensus promoter regions, as well as 2 large overlapping inverted repeats. Sequence comparison to other OspC proteins indicated that the CA-11.2A OspC is as closely related to OspC from 2 different genospecies of Lyme disease spirochaetes as it is to OspC from the prototype B. burgdorferi strain, B31. Comparisons of the OspC amino acid (aa) sequence with those in aa sequence databases revealed partial identity with the variable major proteins Vmp3 and Vmp24 of B. hermsii, a causative agent of tick-borne relapsing fever. An ospC probe hybridized to B. hermsii restriction fragments and linear plasmids that were also recognized by the vmp3 and vmp24 probes. OspC and these Vmp appear to be related, but their synthesis is regulated differently in the 2 species of spirochaetes. This represents a fascinating example of the evolution of the number, position, regulation and perhaps function of homologous genes in 2 related pathogens. These parameters may relate to characteristic properties of the pathogens and their separate tick vectors. KW - genes KW - Lyme disease KW - nucleotide sequences KW - promoters KW - proteins KW - Borrelia burgdorferi KW - Borrelia hermsii KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - DNA sequences KW - lyme borreliosis KW - OspC KW - promoter region KW - promoter sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950504927&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Myocardial changes in acute Trypanosoma cruzi infection: ultrastructural evidence of immune damage and the role of microangiopathy. AU - Andrade, Z. A. AU - Andrade, S. G. AU - Correa, R. AU - Sadigursky, M. AU - Ferrans, V. J. JO - American Journal of Pathology JF - American Journal of Pathology Y1 - 1994/// VL - 144 IS - 6 SP - 1403 EP - 1411 SN - 0002-9440 AD - Andrade, Z. A.: Pathology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 2N-240, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009420. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology N2 - Histological and ultrastructural studies of the hearts of dogs sacrificed 18 to 26 days after intraperitoneal inoculation with 4 × 105 blood forms of the 12 SF strain of Trypanosoma cruzi/kg of body weight disclosed myocarditis characterized by parasitic invasion of some myocytes, damage and necrosis of nonparasitized myocytes, and interstitial infiltration by mononuclear cells. Nonparasitized myocytes showed alterations ranging from mild oedema to severe myocytolysis. These changes often were accompanied by contacts of myocytes with lymphocytes (both granular and agranular) and macrophages. These contacts were characterized by focal loss of the myocyte basement membranes of the two cells. Contacts between lymphocytes and capillary endothelial cells were also frequent. Platelet aggregates and fibrin microthrombi were observed in some capillaries. The findings suggest that immune effector cells play a major role in the pathogenesis of the myocyte damage and the microangiopathy in acute Chagas' disease. KW - Chagas' disease KW - disease models KW - experimental infections KW - heart KW - histopathology KW - human diseases KW - immunopathology KW - parasites KW - pathology KW - ultrastructure KW - dogs KW - protozoa KW - Trypanosoma cruzi KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009420&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence, transcript characterization and polymorphisms of a Plasmodium falciparum gene belonging to the heat-shock protein (HSP) 90 family. AU - Su XinZhuan AU - Wellems, T. E. JO - Gene JF - Gene Y1 - 1994/// VL - 151 IS - 1/2 SP - 225 EP - 230 SN - 0378-1119 AD - Su XinZhuan: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960802782. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Protozoology N2 - A gene (pfhsp86) encoding a member of the heat-shock protein 90 (HSP90) family was isolated from Plasmodium falciparum (Pf). The pfhsp86 coding region comprises 2 exons separated by an 0.8-kb intron with consensus splice junction sequences. The transcript itself is 3.4-kb long and includes a 0.65-kb 5′-untranslated region (UTR) and a 0.54-kb 3′-UTR. Upstream of the transcription start point (tsp) are putative promoter modules: an inverted CCAAT box, a G+C-rich sequence and several TATA sequences. Transcription is enhanced in erythrocyte-stage parasites cultivated at elevated temperatures (2- to 3-fold at 39°C and 3- to 4-fold at 41°C, relative to 37°C). The pfhsp86 gene maps within a chromosome 7 segment that is linked to chloroquine (Cq) response in a Pf cross. The parents of this cross (Dd2, HB3) differ in the first exon by 2 trinucleotide repeats, while more divergence is apparent between the introns. These trinucleotide repeat differences are linked to Cq response in the HB3 X Dd2 cross, but they did not predict Cq response in 9 Pf lines from different locations. KW - amino acid sequences KW - antimalarials KW - antiprotozoal agents KW - chloroquine KW - drug resistance KW - genes KW - heat shock proteins KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. AU - Shirai, M. AU - Pendleton, C. D. AU - Ahlers, J. AU - Takeshita, T. AU - Newman, M. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 152 IS - 2 SP - 549 EP - 556 SN - 0022-1767 AD - Shirai, M.: (J.A. Berzofsky) National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005474. Publication Type: Journal Article. Language: English. KW - Cytotoxic T lymphocytes KW - human immunodeficiency viruses KW - Immune response KW - Immunology KW - Peptides KW - Vaccines KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - HUMAN IMMUNODEFICIENCY VIRUS KW - immunity reactions KW - immunological reactions KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005474&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 Nef activity in murine T cells: CD4 modulation and positive enhancement. AU - Rhee, S. S. AU - Marsh, J. W. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 152 IS - 10 SP - 5128 EP - 5134 SN - 0022-1767 AD - Rhee, S. S.: (J.W. Marsh) Laboratory of Molecular Biology, National Institute of Mental Health, Building 36/Room 1B08, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007098. Publication Type: Journal Article. Language: English. KW - CD4 antigens KW - human immunodeficiency viruses KW - lymphocyte transformation KW - Nef protein KW - Pathogenesis KW - T lymphocytes KW - Mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - HUMAN IMMUNODEFICIENCY VIRUS KW - T cells KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007098&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. AU - Cheever, A. W. AU - Williams, M. E. AU - Wynn, T. A. AU - Finkelman, F. D. AU - Seder, R. A. AU - Cox, T. N. AU - Hieny, S. AU - Caspar, P. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 2 SP - 753 EP - 759 SN - 0022-1767 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002511. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 207137-56-2. Subject Subsets: Tropical Diseases; Helminthology N2 - Increasing evidence suggests that schistosome egg granulomas are primarily Th2 cellular reactions. Mice infected with Schistosoma mansoni were treated with a neutralizing mAb against IL-4 to evaluate the role of this cytokine in the generation of parasite egg-induced cell-mediated responses and hepatic pathology. Animals treated with anti-IL-4 before egg deposition showed decreased IL-4, IL-5, and IL-10 production in response to in vitro antigenic stimulations and decreased IL-5 and IL-13 mRNA levels in the liver. As observed previously, non-B, non-T cells were a major source of IL-4 in infected mice treated with control mAb, and the diminished IL-4 response in anti-IL-4-treated animals was shown to be caused at least in part by a reduction in the number of these cells, as well as by decreased secretion of IL-4 per cell. In contrast, production of the Th1 cytokines IL-2 and IFN-γ was elevated in anti-IL-4-treated infected mice in vitro, and the corresponding mRNAs in the liver were increased. Anti-IL-4 treatment did not consistently reduce the size of hepatic granulomas around S. mansoni eggs, but markedly inhibited granuloma formation in the lungs of the same animals after i.v. egg injection. Nevertheless, anti-IL-4 treated infected mice showed consistent and marked reductions in hepatic collagen deposition. These findings indicate that IL-4 plays a major role in the development of the Th2 response in S. mansoni-infected mice and contributes to the pathogenesis of hepatic fibrosis. KW - cytokines KW - experimental infections KW - fibrosis KW - helminths KW - human diseases KW - immune response KW - immunopathology KW - interleukin 4 KW - laboratory animals KW - parasites KW - schistosomiasis KW - T lymphocytes KW - treatment KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma mansoni KW - Schistosomatidae KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. AU - Sarin, A. AU - Clerici, M. AU - Blatt, S. P. AU - Hendrix, C. W. AU - Shearer,G. M. AU - Henkart, P. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 2 SP - 862 EP - 872 SN - 0022-1767 AD - Sarin, A.: (P.A. Henkart) National Cancer Institute, Building 10, Room 4B-17, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007109. Publication Type: Journal Article. Language: English. KW - Apoptosis KW - HIV infections KW - Inhibition KW - Pathogenesis KW - Calpain KW - Cysteine protease inhibitors KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. AU - Oswald, I. P. AU - Caspar, P. AU - Jankovic, D. AU - Wynn, T. A. AU - Pearce, E. J. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 4 SP - 1707 EP - 1713 SN - 0022-1767 AD - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA. N1 - Accession Number: 19952003789. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2. Subject Subsets: Tropical Diseases; Helminthology N2 - In the mouse, infection with Schistosoma mansoni results in the selective induction of CD4+ T lymphocytes belonging to the Th2 subset. Schistosome ova are responsible for the development of Th2 responses seen in patently infected animals and the injection of eggs subcutaneously into the footpad leads to the development of elevated Th2 cytokine production by T cells in the draining popliteal lymph node. Using the egg infection model, the authors have shown that IL-12 suppressed schistosome egg-induced Th2 responses as evidenced by decreased IL-4, IL-5, and IL-10 secretion in vitro while increasing the production of the Th1 cytokine IFN-γ. Similar responses were obtained using either total lymph node cells or purified CD4+ T cells, indicating that IL-12 acts at the T cell level. When given as a single injection IL-12 was most effective at inhibiting Th2 responses when administered 2 days after egg inoculation, a time when T cells are still in a Th0 phase. The suppression of Th2 responses induced by IL-12 was blocked when the animals were simultaneously injected with neutralizing anti-IFN-γ mAb, either systemically or systemically plus locally. Anti-IFN-γ also inhibited the enhancement of IFN-γ responses induced by IL-12 but only if the mAb was administered systemically plus locally. NK cells are likely to be a major source of the immunoregulatory IFN-γ, because the effects of IL-12 on Th2 cytokine production were suppressed in mice treated with anti-asialo-GM1 Abs. Together these results suggest that IL-12 may have potential use in preventing or treating parasite-induced pathology resulting from Th2 cytokine production. KW - cytokines KW - disease models KW - experimental infections KW - helminths KW - immune response KW - immunotherapy KW - interferon KW - interleukin 10 KW - interleukin 12 KW - interleukin 4 KW - interleukin 5 KW - interleukins KW - ova KW - parasites KW - schistosomiasis KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003789&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. AU - Gazzinelli, R. T. AU - Wysocka, M. AU - Hayashi, S. AU - Denkers, E. Y. AU - Hieny, S. AU - Caspar, P. AU - Trinchieri, G. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 6 SP - 2533 EP - 2543 SN - 0022-1767 AD - Gazzinelli, R. T.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003846. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 9008-11-1. Subject Subsets: Tropical Diseases; Protozoology N2 - In vitro and in vivo studies were performed to assess the involvement of IL-12 in resistance to acute and chronic infection with an avirulent strain of Toxoplasma gondii. The authors' previous findings implicated macrophages as a major source of parasite-induced IL-12. This finding was confirmed by showing that peritoneal macrophages exposed to either live parasites or soluble tachyzoite Ags produce IL-12 protein. In mice, increased expression of IL-12 (p40) mRNA in both spleen and peritoneal cells was detected as early as 2 days postinfection. Treatment with neutralizing mAbs against IL-12 increased the susceptibility of C57BL/6, BALB/c, and severe combined immunodeficient (SCID) mice to acute infection, which resulted in 100% mortality within the first 15 days after parasite inoculation. In contrast, neutralization of endogenously produced IL-12 had no effect when given during chronic infection. In agreement with the survival data, treatment with anti-IL-12 resulted in decreased IFN-γ and enhanced Th2 (IL-4 and IL-10) cytokine synthesis by splenocytes when given during acute, but not chronic, toxoplasmosis. Sorting experiments on spleen cells from acutely infected mice indicated that both CD4+ lymphocytes and NK1.1+/CD3- cells contribute to the early IFN-γ response. In contrast, CD4+ cells were found to be the major source of the cytokine during chronic disease. Together, these results suggest that the stimulation of macrophage-derived IL-12 plays a major role in both the induction of resistance and Th1 cell subset selection in acute T. gondii infection, but may not be required to maintain established immunity. KW - acute course KW - cytokines KW - disease models KW - experimental infections KW - human diseases KW - immune response KW - infections KW - interferon KW - interleukin 12 KW - interleukins KW - parasites KW - toxoplasmosis KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - severe course KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003846&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-α. AU - Maciejewski, J. P. AU - Weichold, F. F. AU - Young, N. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 9 SP - 4303 EP - 4310 SN - 0022-1767 AD - Maciejewski, J. P.: Hematology Branch, National Heart, Lung and Blood Institute, Building 10, Room 7C112, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001625. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 308079-78-9. KW - bone marrow KW - haematopoiesis KW - immunology KW - inhibition KW - pathogenesis KW - tumour necrosis factor KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood formation KW - cachectin KW - cachexin KW - haemopoiesis KW - hematopoiesis KW - human immunodeficiency virus type 1 KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001625&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. AU - Wynn, T. A. AU - Oswald, I. P. AU - Eltoum, I. A. AU - Caspar, P. AU - Lowenstein, C. J. AU - Lewis, F. A. AU - James, S. L. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1994/// VL - 153 IS - 11 SP - 5200 EP - 5209 SN - 0022-1767 AD - Wynn, T. A.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003189. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 10102-43-9, 308079-78-9, 148157-34-0. Subject Subsets: Tropical Diseases; Helminthology N2 - C57BL/6 mice were vaccinated with irradiated cercariae of Schistosoma mansoni, and, at various times after challenge infection, total lung mRNA was isolated to assess the induction of several cytokines that previously had been shown in in vitro studies to be involved in the activation of macrophages and/or endothelial cells for nitric oxide (NO) production and killing of schistosomula. Vaccinated mice demonstrated a highly significant increase in IFN-γ mRNA upon subsequent infection when compared with infected nonvaccinated controls. A similar, although less dramatic, increase in 2 other macrophage-activating cytokines, TNF-α and IL-2, also was observed. In contrast, although the Th2 cytokines IL-4, IL-5, IL-10, and IL-13 were elevated in challenged vaccinated animals, only IL-10 and IL-13 showed increases that were significant with respect to the mRNA levels observed in challenged controls. Neutralization of IFN-γ reduced immunity in vaccinated animals and resulted in decreased IFN-γ, IL-2, IL-10, TNF-α, and IL-12 p40 but markedly increased IL-4, IL-5, and IL-13 mRNA expression and serum IgE levels. Pulmonary NO synthase expression was elevated in immunized mice at a time at which immune elimination of schistosomula is believed to occur. Moreover, suppression of NO synthase activity with the inhibitor aminoguanidine reduced immunity, as measured by a 32 to 33% increase in worm burden. Together, these data support previous in vitro studies that suggest a role for NO in schistosomulum killing. Furthermore, the observation that the down-regulatory cytokines IL-4, IL-10, and IL-13 are induced together with IFN-γ may provide an explanation for the failure of this vaccine to provide complete protection. KW - cytokines KW - disease models KW - experimental infections KW - helminths KW - human diseases KW - immune response KW - immunization KW - interferon KW - interleukin 10 KW - interleukin 13 KW - interleukin 2 KW - laboratory animals KW - nitric oxide KW - parasites KW - schistosomiasis KW - tumour necrosis factor KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - cachectin KW - cachexin KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - tumor necrosis factor KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003189&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A randomized pilot study of alternating or simultaneous zidovudine and didanosine therapy in patients with symptomatic human immunodeficiency virus infection. AU - Yarchoan, R. AU - Lietzau, J. A. AU - et al. AU - Nguyen, B. Y. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 1 SP - 9 EP - 17 SN - 0022-1899 AD - Yarchoan, R.: Building 10, Room 12N226, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005523. Publication Type: Journal Article. Language: English. Registry Number: 69655-05-6, 30516-87-1. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Combination therapy KW - Didanosine KW - HIV infections KW - Treatment KW - Zidovudine KW - AIDS KW - AZT KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus infections KW - multimodal treatment KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005523&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Persistence of type-specific human papillomavirus infection among cytologically normal women. AU - Hildesheim, A. AU - Schiffman, M. H. AU - et al. AU - Gravitt, P. E. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 2 SP - 235 EP - 240 SN - 0022-1899 AD - Hildesheim, A.: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Blvd., EPN Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19942028557. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Determinants of genital human papillomavirus (HPV) persistence in 393 women [in the USA] initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged ≥30 years had a higher percentage of persistence (65%) than those ≤24 years (32%, P = 0.02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = 0.11). These findings were independent of each other and of time between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.AS KW - infections KW - persistence KW - women KW - North America KW - USA KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Papillomaviridae KW - Human papillomavirus KW - Papovaviridae KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028557&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficacy of unilamellar liposomal amphotericin B in treatment of pulmonary aspergillosis in persistently granulocytopenic rabbits: the potential role of bronchoalveolar D-mannitol and serum galactomannan as markers of infection. AU - Francis, P. AU - Lee, J. W. AU - Hoffman, A. AU - Peter, J. AU - Francesconi, A. AU - Bacher, J. AU - Shelhamer, J. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 2 SP - 356 EP - 368 SN - 0022-1899 AD - Francis, P.: T. J. Walsh, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19941201663. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 1397-89-3, 69-65-8. Subject Subsets: Medical & Veterinary Mycology N2 - A model of primary pulmonary Aspergillus fumigatus infection in rabbits was developed to reproduce the persistent levels of profound granulocytopenia and the histopathological features of bronchopneumonia, vascular invasion and haemorrhagic infarction encountered in humans. D-Mannitol was detectable in bronchoalveolar lavage fluid by GLC/MS and galactomannan was measurable in serum by latex agglutination immunoassay. A pharmacokinetically distinctive unilamellar vesicle formulation of intravenous liposomal amphotericin B (5 mg/kg daily) compared with intravenous high-dose conventional desoxycholate amphotericin B (1 mg/kg daily) was more effective in preventing nephrotoxicity, increasing survival, reducing the number of viable organisms and in decreasing tissue injury by Aspergillus. It is suggested that D-mannitol in lavage fluid and galactomannan in serum may be useful markers of pulmonary aspergillosis. It is concluded that liposomal amphotericin B is more effective and safer than desoxycholate amphotericin B in the treatment of pulmonary aspergillosis in profoundly granulocytopenic rabbits. KW - administration KW - amphotericin B KW - antifungal agents KW - aspergillosis KW - diagnosis KW - disease models KW - drug therapy KW - experimental infections KW - galactomannans KW - infections KW - liposomes KW - lungs KW - mannitol KW - predisposition KW - serology KW - techniques KW - therapy KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - bronchoalveolar lavage fluid KW - chemotherapy KW - fungistats KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941201663&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunity to onchocerciasis: identification of a putatively immune population in a hyperendemic area of Ecuador. AU - Elson, L. H. AU - Guderian, R. H. AU - Araujo, E. AU - Bradley, J. E. AU - Days, A. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 3 SP - 588 EP - 594 SN - 0022-1899 AD - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800174. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases N2 - The existence of immunity to Onchocerca volvulus (Ov) infection is suggested by the presence of uninfected persons in hyperendemic areas. A major barrier to the study of immunity has been the correct identification of putatively immune (PI) subjects. To identify a PI group in a hyperendemic area of Esmeraldas Province in Ecuador, clinical and epidemiological information was combined with a polymerase chain reaction (PCR)-based assay identifying Ov DNA in skin snips and a recombinant antigen-based ELISA. Comparison of immune responses revealed that PI subjects (n=42) had significantly lower levels of Ov-specific IgG, IgG subclasses, and IgE than infected (INF) subjects (n=45). Female subjects were significantly more likely to be PI than male subjects, and INF female subjects had significantly lower levels of Ov-specific IgG, IgG1 and IgG3 than INF male subjects. KW - helminths KW - human diseases KW - IgG KW - immune response KW - immunity KW - immunoglobulins KW - onchocerciasis KW - parasites KW - polymerase chain reaction KW - Ecuador KW - South America KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - PCR KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800174&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polymerase chain reaction-based diagnosis of Onchocerca volvulus infection: improved detection of patients with onchocerciasis. AU - Zimmerman, P. A. AU - Guderian, R. H. AU - Aruajo, E. AU - Elson, L. AU - Phadke, P. AU - Kubofcik, J. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 3 SP - 686 EP - 689 SN - 0022-1899 AD - Zimmerman, P. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800177. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - To assess the efficacy and utility of a polymerase chain reaction (PCR)-based diagnosis for Onchocerca volvulus (Ov) infection, skin snips were examined from 94 persons in an Ov-endemic region of Ecuador (Esmeraldas), and results were compared in a blinded fashion with those of a PCR assay based on the Onchocerca-specific repetitive DNA sequence, O-150. All 60 patients microfilaria-positive on skin snip examination were positive in the PCR-based assay. In addition, 13 of 34 who were microfilaria-negative by skin snips were positive in the PCR assay. This suggests that the PCR-based assay is significantly more sensitive than current methods. KW - diagnosis KW - helminths KW - human diseases KW - molecular genetics KW - onchocerciasis KW - parasites KW - polymerase chain reaction KW - Ecuador KW - South America KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - biochemical genetics KW - nematodes KW - onchocercosis KW - parasitic worms KW - PCR KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800177&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Elevated levels of tumor necrosis factor-α in Zaïrian neonate plasmas: implications for perinatal infection with the human immunodeficiency virus. AU - Brown, C. C. AU - Poli, G. AU - et al. AU - Lubaki, N. ( AU - Fauci, A. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 169 IS - 5 SP - 975 EP - 980 SN - 0022-1899 AD - Brown, C. C.: (A.S. Fauci) National Institutes of Health, Building 31, Room 7A03, Bethesda, MD 29892, USA. N1 - Accession Number: 19942006397. Publication Type: Journal Article. Language: English. Registry Number: 308079-78-9. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Cytokines KW - disease course KW - HIV infections KW - Immunology KW - Pathogenesis KW - Tumour necrosis factor KW - AIDS KW - cachectin KW - cachexin KW - disease progression KW - human immunodeficiency virus infections KW - Paediatric infections KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006397&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dynamics of emergence. AU - Krause, R. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 2 SP - 265 EP - 271 SN - 0022-1899 AD - Krause, R. M.: Fogarty International Center, National Institutes of Health, 9000 Rockville Pike, Building 31, Room B2C02, Bethesda, MD 20892, USA. N1 - Accession Number: 19942050998. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - HIV infections KW - Infectious diseases KW - Mathematical models KW - Microbiology KW - AIDS KW - communicable diseases KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050998&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantitative analysis of viral burden in tissues from adults and children with symptomatic human immunodeficiency virus type 1 infection assessed by polymerase chain reaction. AU - Sei, S. AU - Kleiner, D. E. AU - et al. AU - Kopp, J. B. ( JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 2 SP - 325 EP - 333 SN - 0022-1899 AD - Sei, S.: Pediatric Branch, National Cancer Institute, NIH Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19942051005. Publication Type: Journal Article. Language: English. KW - Colon KW - HIV infections KW - lungs KW - Lymph nodes KW - Pathology KW - Polymerase chain reaction KW - Tissues KW - human immunodeficiency virus infections KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942051005&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular characterization of Hawaii virus and other Norwalk-like viruses: Evidence for genetic polymorphism among human caliciviruses. AU - Lew, J. F. AU - Kapikian, A. Z. AU - Valdesuso, J. AU - Green, K. Y. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 3 SP - 535 EP - 542 SN - 0022-1899 AD - Lew, J. F.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952006028. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health N2 - Hawaii virus (HV), from a 1971 family outbreak of gastroenteritis, is serotypically distinct from Norwalk virus (NV), recently identified as a human calicivirus by molecular analysis. About 2600 consecutive nucleotides of the HV genome (including those encoding the viral capsid protein) and part of the polymerase region of three other viruses (MDV1, MDV6, and SV7) were sequenced. Comparison of the amino acid sequence of the capsid protein of HV with NV and other human caliciviruses (Toronto virus [TV24], Desert Shield virus [DSV395], and Southampton virus [SHV]) demonstrated the existence of two major genetic groups (genogroups) typified by HV and NV. HV had 76% identity with TV24 and 48% identity with NV, DSV395, or SHV. In addition, comparison of part of the polymerase protein of HV with other human caliciviruses also showed that there were these two genogroups. The large genetic diversity between the capsid sequence of HV and NV is consistent with their serotypic distinctiveness. KW - genetic polymorphism KW - molecular genetics KW - Caliciviridae KW - Norwalk virus KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Norovirus KW - Caliciviridae KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006028&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of hepatic pathology in SCID-Hu mice engrafted with peripheral blood lymphocytes of patients with schistosomiasis japonica. AU - Kresina, T. F. AU - Wisnewski, A. AU - Love-Homan, L. AU - Ramirez, B. AU - Neil, G. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 3 SP - 733 EP - 736 SN - 0022-1899 AD - Kresina, T. F.: National Institute of Digestive Diseases and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952006041. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9008-11-1, 207137-56-2. Subject Subsets: Tropical Diseases; Helminthology N2 - SCID mice were engrafted with peripheral blood lymphocytes (PBL) derived from persons (from the Philippines) currently or previously infected with Schistosoma japonicum. After immunization with soluble worm antigenic preparation, the SCID-Hu mice were analysed for a human immune response. ELISA revealed a low titre of human antibody recognizing soluble egg antigens in 2 of 10 mice. One mouse had detectable levels of interleukin (IL)-2 and γ-interferon, TH1 phenotype cytokines. All mice had elevated levels of IL-4, a TH2 phenotype cytokine. The human cytokine profile of the mice paralleled the patients' serum profile at clinical examination. In addition, all mice had substantial hepatic pathology, including inflammatory cell infiltrates and macrovesicular fat deposition. The data indicate that activation of PBL from patients with a history of schistosomiasis japonica infection can result in focal hepatic pathology, which may be driven by specific cytokines. KW - disease models KW - experimental infections KW - helminths KW - human diseases KW - immunopathology KW - interferon KW - interleukin 12 KW - interleukin 4 KW - laboratory animals KW - liver KW - lymphocytes KW - parasites KW - pathology KW - schistosomiasis KW - scid mice KW - Asia KW - Philippines KW - man KW - mice KW - Schistosoma japonicum KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - bilharzia KW - bilharziasis KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006041&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings. AU - McCarthy, J. S. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 3 SP - 733 EP - 736 SN - 0022-1899 AD - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952006168. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 37341-29-0. Subject Subsets: Tropical Diseases; Helminthology N2 - To characterize the clinical and laboratory features of onchocerciasis in visitors from the USA to endemic areas and to compare them with those seen in endemic subjects, 20 visitors (who had returned from Central or West Africa) and 21 endemic subjects (19 from Guatemala, and one each from Cameroon and Sierra Leone) with onchocerciasis were evaluated. Dermatitis was the most frequent clinical finding among the returned visitors. None had nodules or eye disease and, in contrast to the endemic subjects, microfiladermia was often absent or of low density. All persons studied had antibody responses measurable by ELISA to both soluble Onchocerca volvulus antigen and a panel of diagnostic recombinant antigens. Eosinophil and IgE levels were significantly higher in the endemic group, as was the capacity of peripheral blood mononuclear cells from this group to produce the T helper cell-like cytokines interleukin-4 and -5. It is likely that the chronicity and intensity of infection in endemic subjects account for the clinical and immunological differences observed between the 2 groups. KW - antigens KW - clinical aspects KW - dermatitis KW - eosinophils KW - helminths KW - IgE KW - immunology KW - imported infections KW - onchocerciasis KW - parasites KW - T lymphocytes KW - travellers KW - Africa KW - Cameroon KW - Central America KW - Guatemala KW - North America KW - Sierra Leone KW - USA KW - man KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - America KW - CACM KW - Central America KW - Latin America KW - Anglophone Africa KW - Commonwealth of Nations KW - Least Developed Countries KW - West Africa KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - antigenicity KW - clinical picture KW - eosinophil leukocytes KW - immunogens KW - nematodes KW - onchocercosis KW - parasitic worms KW - reagin KW - reaginic antibodies KW - river blindness KW - Secernentea KW - Spirurida KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006168&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifungal activity of elutriated human monocytes against Aspergillus fumigatus hyphae: enhancement by granulocyte-macrophage colony-stimulating factor and interferon-γ. AU - Roilides, E. AU - Holmes, A. AU - Blake, C. AU - Venzon, D. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 4 SP - 894 EP - 899 SN - 0022-1899 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200819. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The antifungal activity of elutriated monocytes (EHM) against Aspergillus hyphae was compared with that of polymorphonuclear leukocytes (PMNL). The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-γ (IFN-γ) on superoxide anion (O2-) release and on hyphal damage caused by EHM against unopsonized A. fumigatus hyphae was investigated. EHM had anti-hyphal activity comparable with that of PMNL. GM-CSF significantly augmented O2- release by EHM in response to PMA. Also, both GM-CSF and IFN-γ significantly enhanced the antifungal activity of EHM compared with untreated controls. It is concluded that EHM have demonstrable antifungal activity against Aspergillus hyphae that may be increased by GM-CSF and IFN-γ, suggesting their potential therapeutic role in immune reconstitution of effector cells. KW - cytokines KW - immunology KW - monocytes KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transient changes in cytokine profiles following ivermectin treatment of onchocerciasis. AU - Steel, C. AU - Lujan-Trangay, A. AU - Gonzalez-Peralta, C. AU - Zea-Flores, G. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 4 SP - 962 EP - 970 SN - 0022-1899 AD - Steel, C.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950802278. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 85898-30-2, 207137-56-2, 70288-86-7, 308079-78-9, 9008-11-1, 130068-27-8, 102524-44-7. Subject Subsets: Helminthology; Tropical Diseases N2 - Cytokine production by peripheral blood mononuclear cells after antigen or mitogen stimulation was assessed before and after semiannual ivermectin treatment (with 150 µg/kg) of 27 male patients with onchocerciasis in Guatemala. Before treatment, Onchocerca volvulus antigen (OvA) elicited interleukin (IL)-5 production but inhibited production of IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), and tumour necrosis factor-α. 6 months after the first dose of ivermectin, there were increases in IL-2, IL-4, IL-5 and interferon-γ responses to mitogen and in the GM-CSF and IL-10 responses to OvA. By 24 months (after 4 ivermectin doses), OvA-induced GM-CSF production and mitogen-induced IL-2 and IL-10 production remained elevated above pre-treatment levels, whereas that of other cytokines returned to or below pretreatment levels. KW - anthelmintics KW - colony stimulating factor KW - cytokines KW - drug therapy KW - helminths KW - human diseases KW - immune response KW - interferon KW - interleukin 10 KW - interleukin 2 KW - interleukin 4 KW - interleukin 5 KW - ivermectin KW - onchocerciasis KW - parasites KW - tumour necrosis factor KW - Central America KW - Guatemala KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - America KW - CACM KW - Central America KW - Developing Countries KW - Latin America KW - cachectin KW - cachexin KW - chemotherapy KW - granulocyte macrophage colony stimulating factor KW - immunity reactions KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802278&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus. AU - Davey, R. T., Jr. AU - Boenning, C. M. AU - Herpin, B. R. AU - Batts, D. H. AU - Metcalf, J. A. AU - Wathen, L. AU - Cox, S. R. AU - Polis, M. A. AU - Kovacs, J. A. AU - Falloon, J. AU - Walker, R. E. AU - Salzman, N. AU - Masur, H. AU - Lane, H. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 5 SP - 1180 EP - 1188 SN - 0022-1899 AD - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases and Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland USA. N1 - Accession Number: 19952001131. Publication Type: Journal Article. Language: English. KW - exotoxins KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - soluble cd4 antigens KW - toxicity KW - treatment KW - Pseudomonas aeruginosa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Pseudomonas KW - Pseudomonadaceae KW - Pseudomonadales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - fusion toxin KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - soluble CD4 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001131&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifilarial IgG4 antibodies in children from filaria-endemic areas correlate with duration of infection and are dissociated from antifilarial IgE antibodies. AU - Mahanty, S. AU - Day, K. P. AU - Alpers, M. P. AU - Kazura, J. W. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 5 SP - 1339 EP - 1343 SN - 0022-1899 AD - Mahanty, S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803051. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases N2 - This study investigated the influence that intensity and duration of transmission have on host IgG4 and IgE antibody responses to infection with Wuchereria bancrofti. The serum samples were obtained from children of villages in Papua New Guinea. One of these villages, Bonahoi, was subject to an insecticide spraying programme for a 20-year period, which ended 3 years prior to collection of serum samples in 1984. It thus provides a source of samples obtained from individuals subjected to potential exposure to infection of a short-term nature, and these are compared with samples from 3 nearby (~50 km) untreated villages. Although the group of subjects from the sprayed village was rather small (n = 9; n = 33 for non-sprayed), it was possible to demonstrate significantly lower (P <0.01) IgG4 levels in children from the sprayed village. In contrast, antifilarial IgE was elevated to similar levels in children from both types of village. These findings can be interpreted as indicating that the IgG4, but not the IgE, response to W. bancrofti in this area of transmission may reflect the duration of infection or cumulative exposure to infective larvae. This interpretation is supported by increasing levels of anti-parasite IgG4 up until 16 years of age in children from unsprayed villages. Conversely, IgE levels in the same villages have plateaued many years before this. However, the presence of significant IgE responses in children from sprayed villages may illustrate the potential of this isotype as an early marker of infection. W. Harnett<new para>ADDITIONAL ABSTRACT:<new para>Antifilarial antibody levels in 9 children residing in a village (Bonahoi) in East Sepik Province, Papua New Guinea, where transmission of Wuchereria bancrofti had been reduced (microfilaria carrier rate 6.6%) by repeated insecticide spraying (from 1961 to 1981) were compared (in 1984) with levels in residents (33 children, 17 adults) of 3 nearby villages where no control measures had been used (microfilaria carrier rates 60 to 80%). Antifilarial IgG4 levels were significantly lower in children from the sprayed village than in children or adults in non-sprayed villages, and correlated with age and intensity of microfilaraemia. In contrast, antifilarial IgE was elevated to similar levels in children and adults from both the sprayed village and the unsprayed villages. It is concluded that antifilarial IgG4 (and not IgE) levels in endemic populations appear to be directly related to the duration of infection or to the cumulative exposure to infective vectors. KW - antibodies KW - children KW - helminths KW - human diseases KW - IgE KW - IgG KW - immune response KW - immunoglobulins KW - infections KW - parasites KW - Oceania KW - Papua New Guinea KW - man KW - nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Wuchereria KW - Onchocercidae KW - ACP Countries KW - APEC countries KW - Commonwealth of Nations KW - Developing Countries KW - New Guinea KW - Melanesia KW - Australasia KW - Oceania KW - Pacific Islands KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803051&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genotyping of human T cell lymphotropic virus type I using Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination. AU - Nerurkar, V. R. AU - Song, K. J. AU - Bastian, I. B. AU - Garin, B. AU - Franchini, G. AU - Yanagihara, R. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 6 SP - 1353 EP - 1360 SN - 0022-1899 AD - Nerurkar, V. R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952001724. Publication Type: Journal Article. Language: English. Number of References: 41 ref. KW - DNA sequencing KW - evolution KW - genetic variation KW - human diseases KW - origin KW - phylogeny KW - polymerase chain reaction KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - genetic variability KW - genotypic variability KW - genotypic variation KW - HTLV-BLV group KW - nucleotide sequence analysis KW - nucleotide sequencing KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001724&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Response of human polymorphonuclear leukocytes and monocytes to Trichosporon beigelii: host defense against an emerging opportunistic pathogen. AU - Lyman, C. A. AU - Garrett, K. F. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1994/// VL - 170 IS - 6 SP - 1557 EP - 1565 SN - 0022-1899 AD - Lyman, C. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951200708. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Functional responses of polymorphonuclear leukocytes (PMNL) and elutriated human monocytes (EHM) to T. beigelii were investigated. There was significantly less PMNL phagocytosis (P<0.001) and killing (P<0.001) of T. beigelii isolates than of Candida albicans. However, levels of superoxide anions generated by PMNL in response to T. beigelii and C. albicans were comparable. Pretreatment of PMNL with granulocyte colony-stimulating factor or interferon-γ (IFN-γ) did not significantly enhance fungicidal activity. Killing of T. beigelii by EHM was also significantly impaired compared with killing of C. albicans (P<0.001). However, pretreatment of EHM with macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor or IFN-γ all resulted in enhanced fungicidal activity. It is concluded that phagocytosis and killing of T. beigelii by PMNL and EHM are significantly less efficient than that of C. albicans. However, it is suggested that monocytes may be more important in the control of Trichosporon than previously shown. KW - cytokines KW - immunology KW - leukocytes KW - monocytes KW - phagocytosis KW - Candida albicans KW - Trichosporon beigelii KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungus KW - Hyphomycetes KW - killing KW - leucocytes KW - white blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. AU - Williamson, P. R. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1994/// VL - 176 IS - 3 SP - 656 EP - 664 SN - 0021-9193 AD - Williamson, P. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941200875. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 80498-15-3. Subject Subsets: Medical & Veterinary Mycology N2 - To characterize the events involved in melanin synthesis in C. neoformans, an enzyme with diphenol oxidase activity was purified and its gene was cloned. The enzyme was purified as a glycosylated 75-kDa protein which migrated at 66 kDa on SDS-PAGE after deglycosylation by endoglycosidase F. Substrate specificity resembled that of a laccase in that it oxidized multiple diphenolic and diamino compounds. Dopamine was shown by mass spectroscopy to be oxidized to decarboxy dopachrome, an intermediate of melanin synthesis. The enzyme contained 4.1±0.1 mol of copper/mol and resembled a laccase in its absorbance spectrum, with a peak at 610 nm and the shoulder at 320 nm, corresponding to the absorbance of a type I and type III copper, respectively. The cloned gene of C. neoformans laccase (CNLAC1) contained a single open reading frame encoding a polypeptide of 624 amino acids. The encoded polypeptide contained a presumptive leader sequence, on the basis of its relative hydrophobicity and by comparison of the sequence to that of the N-terminal sequence of the purified enzyme. CNLAC1 also contained 14 introns ranging from 52 to 340 bases long. Transcriptional activity of CNLAC1 was derepressed in the absence of glucose and corresponded to an increase in enzymatic activity. KW - biochemistry KW - genetics KW - laccase KW - nucleotide sequences KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - DNA sequences KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi. AU - Samuels, D. S. AU - Marconi, R. T. AU - Huang WaiMun AU - Garon, C. F. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1994/// VL - 176 IS - 10 SP - 3072 EP - 3075 SN - 0021-9193 AD - Samuels, D. S.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950502860. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 4434-05-3. Subject Subsets: Medical & Veterinary Entomology N2 - Mutants of B. burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase [DNA topoisomerase (ATP-hydrolysing)], were isolated and characterized. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents. KW - antibiotics KW - coumamycin KW - drug resistance KW - genes KW - molecular genetics KW - mutants KW - nucleotide sequences KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - coumermycin KW - DNA sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502860&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange. AU - Marconi, R. T. AU - Samuels, D. S. AU - Landry, R. K. AU - Garon, C. F. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1994/// VL - 176 IS - 15 SP - 4572 EP - 4582 SN - 0021-9193 AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19950502857. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Analysis of the ospD gene has revealed that this gene is not universal among Lyme disease spirochaete isolates. The gene was found to be carried by 90, 50 and 24% of the Borrelia garinii, B. afzelii and B. burgdorferi isolates tested. Size variability in the ospD-encoding plasmid was also observed. Sequence analysis has demonstrated the presence of various numbers of a 17-bp repeated sequence in the upstream control (promoter) region of the gene. In addition, a region within the coding sequence where various insertions, deletions and direct repeats occur was identified. ospD gene sequences from 31 different isolates were determined and utilized in pairwise sequence comparisons and construction of a gene tree. The analyses suggest that the ospD gene was the target of several recombinational events and that the gene was recently acquired by Lyme disease spirochaetes and laterally transferred between species. KW - DNA KW - genes KW - molecular genetics KW - nucleotide sequences KW - plasmids KW - Borrelia afzelii KW - Borrelia burgdorferi KW - Borrelia garinii KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. AU - Wynn, T. A. AU - Eltoum, I. AU - Oswald, I. P. AU - Cheever, A. W. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1994/// VL - 179 IS - 5 SP - 1551 EP - 1561 SN - 0022-1007 AD - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952006080. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 9008-11-1. Subject Subsets: Tropical Diseases; Helminthology N2 - Morbidity in human schistosomiasis due to Schistosoma mansoni results primarily from the deposition of parasite eggs in portal areas where they induce a granulomatous response. In mice infected with this helminth granuloma formation is a CD4+ T helper (Th) cell-dependent process that is associated with a strong Th2 cytokine response which appears to evolve through a Th0 phase. In this report, the authors asked whether endogenously synthesized or exogenously induced interferon (IFN)γ through its suppression of Th2 cell expansion exerts a regulatory role on egg pathology. Depletion of IFN-γ or natural killer cells resulted in a marked enhancement of granuloma formation around intravenously injected eggs and was associated with increased Th2 and decreased Th1 and interleukin (IL)12 mRNA expression. Similar changes occurred when egg-injected mice were treated with neutralizing monoclonal antibodies specific for IL-12 indicating a role for this cytokine in the regulation of the granulomatous response. In contrast, treatment with exogenous rIL-12 profoundly inhibited primary granuloma formation while increasing IFN-γ, IL-2, IL-10, and IL-12 pulmonary mRNA levels and suppressing IL-4, IL-5, IL-6 and IL-13 mRNA expression. Cytokine depletion studies indicated that the effects of IL-12 could be attributed primarily to increased IFN-γ. Importantly, IL-12 also inhibited secondary granuloma formation in mice pre-sensitized with eggs demonstrating a role for the cytokine in reversing established Th2-type responses. Moreover, mice sensitized with eggs in combination with IL-12 to precommit them toward a Th1 response developed only minimal granulomas upon subsequent egg challenge. The latter findings suggest that simultaneous vaccination with antigen plus IL-12 may provide a strategy for the prevention of schistosome egg pathology as well as other diseases stemming from Th2 cytokine production. KW - animal models KW - cytokines KW - granuloma KW - helminths KW - human diseases KW - immunopathology KW - interferon KW - interleukin 12 KW - interleukins KW - parasites KW - schistosomiasis KW - T lymphocytes KW - man KW - mice KW - Schistosoma mansoni KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006080&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion. AU - Chitnis, C. E. AU - Miller, L. H. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1994/// VL - 180 IS - 2 SP - 497 EP - 506 SN - 0022-1007 AD - Chitnis, C. E.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952001654. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Tropical Diseases; Protozoology N2 - Plasmodium vivax and the related monkey malaria parasite, P. knowlesi, require interaction with the Duffy blood group antigen, a receptor for a family of chemokines that includes interleukin 8, to invade human erythrocytes. One P. vivax and 3 P. knowlesi proteins that serve as erythrocyte binding ligands in such interactions share sequence homology. Expression of different regions of the P. vivax protein in COS7 cells identified a cysteine-rich domain that bound Duffy blood group-positive but not Duffy blood group-negative human erythrocytes. The homologous domain of the P. knowlesi proteins also bound erythrocytes, but had different specificities. The P. vivax and P. knowlesi binding domains lie in 1 of 2 regions of homology with the P. falciparum sialic acid binding protein, another erythrocyte binding ligand, indicating conservation of the domain for erythrocyte binding in evolutionarily distant malaria species. The binding domains of these malaria ligands represent potential vaccine candidates and targets for receptor-blockade therapy. KW - blood group antigens KW - cell invasion KW - erythrocyte invasion KW - erythrocytes KW - human diseases KW - ligands KW - parasites KW - vaccines KW - man KW - Plasmodium KW - Plasmodium knowlesi KW - Plasmodium vivax KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium KW - blood red cells KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001654&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor Vβ5-bearing CD8+ lymphocytes. AU - Denkers, E. Y. AU - Caspar, P. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1994/// VL - 180 IS - 3 SP - 985 EP - 994 SN - 0022-1007 AD - Denkers, E. Y.: Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950808939. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - In order to investigate early immune responses to Toxoplasma gondii, the capacity of nonimmune splenocytes to respond in vitro to intact tachyzoites and soluble tachyzoite antigen (Ag) was examined. Both types of stimuli induced high levels of proliferation as well as interferon-γ (IFN-γ) secretion. Based on several key criteria, the response appeared to be driven by a superantigen present in the parasite. Thus, stimulation of C57BL/6 spleen cells with T.gondii resulted in a preferential three-fold expansion of a T lymphocyte population expressing the Vβ5 chain of the T cell receptor. Proliferation was induced using irradiated Ag-pulsed and infected splenic adherent cells, and was blocked by a major histocompatibility complex class II-specific monoclonal antibody. It was demonstrated that the response could be mediated by allogeneic class II molecules, and that it does not require cellular Ag processing. These results provide the first description of a superantigen activity in a protozoan pathogen. Superantigen-driven expansion of IFN-γ-secreting CD8+ lymphocytes may play a role in the development of the dominant IFN-γ-dependent, cell-mediated immunity characteristic of infection with this parasite. KW - cell mediated immunity KW - human diseases KW - in vitro KW - interferon KW - lymphocyte transformation KW - parasites KW - T lymphocytes KW - toxoplasmosis KW - protozoa KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cellular immunity KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808939&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. AU - Song, K. J. AU - Nerurkar, V. R. AU - Saitou, N. AU - Lazo, A. AU - Blakeslee, J. R. AU - Miyoshi, I. AU - Yanagihara, R. JO - Virology (New York) JF - Virology (New York) Y1 - 1994/// VL - 199 IS - 1 SP - 56 EP - 66 SN - 0042-6822 AD - Song, K. J.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001613. Publication Type: Journal Article. Language: English. Number of References: 44 ref. KW - evolution KW - natural history KW - nucleotide sequences KW - phylogeny KW - man KW - retroviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA sequences KW - simian T-cell lymphotropic virus type I KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001613&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An increase in p50/p65 NF-kB binding to the HIV-1 LTR is not sufficient to increase viral expression in the primary human astrocyte. AU - Conant, K. AU - Atwood, W. J. AU - Traub, R. AU - Tornatore, C. AU - Major, E. O. JO - Virology (New York) JF - Virology (New York) Y1 - 1994/// VL - 205 IS - 2 SP - 586 EP - 590 SN - 0042-6822 AD - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005783. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 308079-78-9. KW - cellular biology KW - gene expression KW - growth factors KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - regulation KW - tumour necrosis factor KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - astrocytes KW - cachectin KW - cachexin KW - cell biology KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - phorbol myristate acetate KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005783&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 modulates the expression of gelatinase A and B in monocytic cells. AU - Kalebic, T. AU - Masiero, L. AU - Onisto, M. AU - Garbisa, S. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1994/// VL - 205 IS - 2 SP - 1243 EP - 1249 SN - 0006-291X AD - Kalebic, T.: Molecular Oncology Secion, Pediatric Branch, National Cancer Institute, NIH Building 10/13N240, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19962002131. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 63231-63-0, 308079-78-9. KW - HIV infections KW - human diseases KW - modulation KW - molecular biology KW - RNA KW - tumour necrosis factor KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - gelatinases KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - proteolytic enzymes KW - ribonucleic acid KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002131&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Malaria pathogenesis. AU - Miller, L. H. AU - Good, M. F. AU - Milon, G. JO - Science (Washington) JF - Science (Washington) Y1 - 1994/// VL - 264 IS - 5167 SP - 1878 EP - 1883 SN - 0036-8075 AD - Miller, L. H.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800758. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - This article provides an overview of malaria pathogenesis under the headings: the immune system (parasite survival strategy and disease); invasion of erythrocytes; persistent infections and reinfections; severe disease; cerebral malaria; severe anaemia; pregnancy, the fetus and the newborn. KW - human diseases KW - malaria KW - parasites KW - pathogenesis KW - reviews KW - Apicomplexa KW - man KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800758&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum. AU - Sim, B. K. L. AU - Chitnis, C. E. AU - Wasniowska, K. AU - Hadley, T. J. AU - Miller, L. H. JO - Science (Washington) JF - Science (Washington) Y1 - 1994/// VL - 264 IS - 5167 SP - 1941 EP - 1944 SN - 0036-8075 AD - Sim, B. K. L.: Laboratory of Malaria Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950800760. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A 175 000 MW erythrocyte binding protein, EBA-175, of Plasmodium falciparum mediates the invasion of erythrocytes. The erythrocyte receptor for EBA-175 is dependent on sialic acid. The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of EBA-175 expressed on COS cells. Region II, which contains a cysteine-rich motif, and native EBA-175 bind specifically to glycophorin A, but not to glycophorin B, on the erythrocyte membrane. Erythrocyte recognition of EBA-175 requires both sialic acid and the peptide backbone of glycophorin A. The identification of both the receptor and ligand domains may suggest rational designs for receptor blockade and vaccines. KW - biochemistry KW - cell invasion KW - erythrocytes KW - host parasite relationships KW - human diseases KW - ligands KW - malaria KW - parasites KW - receptors KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - blood red cells KW - erythrocyte binding protein KW - glycophorins KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800760&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - CD26 antigen and HIV fusion? AU - Broder, C. C. AU - Nussbaum, O. AU - Gutheil, W. G. AU - Bachovchin, W. W. AU - Berger, E. A. AU - Patience, C.\McKnight, A.\Clapham, P. R.\Boyd, M. T.\Weiss, R. A.\Schulz, T. F.\Camerini, D.\Planelles, V.\Chen, I. S. Y.\Alizon, M.\Dragic, T.\Callebaut, C.\Jacotot, E.\Krust, B.\Hovanessian, A. G. T2 - Science, USA JO - Science, USA JF - Science, USA Y1 - 1994/// VL - 264 IS - May 20 SP - 1156 EP - 1159 AD - Broder, C. C.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006776. Publication Type: Correspondence. Language: English. KW - Cell fusion KW - cellular biology KW - HIV infections KW - Molecular biology KW - Pathogenesis KW - Receptors KW - CD26 KW - cell biology KW - human immunodeficiency virus infections KW - Viral entry KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006776&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. AU - Speir, E. AU - Modali, R. AU - Huang, E. S. AU - Leon, M. B. AU - Shawl, F. AU - Finkel, T. AU - Epstein, S. E. AU - Marx, J. JO - Science (Washington) JF - Science (Washington) Y1 - 1994/// VL - 265 IS - 5170 SP - 391 EP - 394 SN - 0036-8075 AD - Speir, E.: Cardiology Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001507. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - A subset of patients who had undergone coronary angioplasty developed restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38%) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.The role of CMV-p53 in causing clogged arteries is discussed further by J. Marx (p. 320). KW - disease prevalence KW - human diseases KW - infections KW - North America KW - USA KW - cytomegalovirus KW - man KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - restenosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001507&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lack of evidence for the dichotomy of the TH1 and TH2 predominance in HIV-infected individuals. AU - Graziosi, C. AU - Pantaleo, G. AU - et al. AU - Gantt, K. R. ( JO - Science, USA JF - Science, USA Y1 - 1994/// VL - 265 IS - Jul. 8 SP - 248 EP - 252 AD - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942007181. Publication Type: Journal Article. Language: English. Number of References: 25 notes and ref. KW - Cytokines KW - HIV infections KW - immune response KW - Immunology KW - interleukins KW - T lymphocytes KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T cells KW - THl cells KW - THO shift KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942007181&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary protein-induced renal growth: correlation between renal IGF-I synthesis and hyperplasia. AU - Chin, E. AU - Bondy, C. A. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1994/// VL - 266 IS - 4 SP - C1037 EP - C1045 SN - 0002-9513 AD - Chin, E.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951405400. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 61912-98-9. Subject Subsets: Human Nutrition N2 - Insulin-like growth factor I (IGF-I) and IGF binding protein 1 (IGFBP-1) mRNAs are colocalized in the medullary thick ascending limb (MTAL) of the rat nephron, a segment that undergoes selective growth in response to elevated dietary protein. Rats were fed on isoenergetic diets containing variable protein content (6-40%) for 1-7 days, and changes in fractional renal weight, MTAL length and regional DNA synthesis were assayed and compared with local changes in IGF-I/IGFBP-1 mRNAs, as estimated by quantitative in situ hybridization. Rats switched to high-protein diets demonstrated increased IGF-I and decreased IGFBP-1 mRNA levels in MTALs, whereas those switched to low protein showed inverse changes. The increase in renal IGF-I mRNA was maximal at 2 days and was closely paralleled by significant increases in fractional renal weight, DNA synthesis and MTAL length. Similar changes were seen in vasopressin-deficient Brattleboro and growth hormone (GH)-deficient dwarf rats in response to high-protein diets, suggesting that the effects of dietary protein in this model are not mediated by vasopressin or GH. The close spatial and temporal correlation between changes in renal IGF-I expression and changes in regional growth parameters strongly supports a role for locally produced IGF-I in the induction of protein-induced renal growth. KW - binding proteins KW - growth KW - hyperplasia KW - hypertrophy KW - insulin-like growth factor KW - kidneys KW - messenger RNA KW - protein intake KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - mRNA KW - somatomedin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405400&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. AU - Lori, F. AU - Malykh, A. AU - Cara, A. AU - Sun, D. AU - Weinstein, J. N. AU - Lisziewicz, J. AU - Gallo, R. C. JO - Science (Washington) JF - Science (Washington) Y1 - 1994/// VL - 266 IS - 5186 SP - 801 EP - 805 SN - 0036-8075 AD - Lori, F.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952001051. Publication Type: Journal Article. Language: English. Registry Number: 69655-05-6, 127-07-1. KW - antiviral agents KW - combination therapy KW - didanosine KW - human immunodeficiency viruses KW - hydroxycarbamide KW - inhibition KW - replication KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - combined modality therapy KW - dideoxyinosine KW - DNA synthesis KW - human immunodeficiency virus KW - hydroxyurea KW - multimodal treatment KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001051&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid and insulin secretion in pancreatic islets. AU - Bergsten, P. AU - Sanchez Moura, A. AU - Atwater, I. AU - Levine, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 2 SP - 1041 EP - 1045 SN - 0021-9258 AD - Bergsten, P.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951410460. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - The effect of ascorbic acid on glucose-induced insulin release from single pancreatic islets (from Sprague-Dawley rats) was measured using a new, ultra-sensitive enzyme-linked immunosorbent insulin assay. Within 20 s ascorbic acid inhibited insulin secretion; inhibition was dose dependent and completely reversible. There was a 50% inhibition of the secretory response with ascorbic acid 200 µM and 90% inhibition with ascorbic acid 400 µM. The decrease in insulin secretion was recorded as a reduction of the amplitudes of the fast insulin transients, which give rise to the oscillatory nature of insulin secretion. The inhibition of glucose-induced insulin release by ascorbic acid was associated with hyperpolarization of the pancreatic β-cell. Suppression of glucose-induced membrane depolarization was evident after 20 s, was dose dependent and was completely reversible. The data here may provide the first explanation of why plasma ascorbate concentrations are tightly controlled. KW - ascorbic acid KW - insulin secretion KW - pancreas islets KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410460&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells. AU - Gao, W. Y. AU - Agbaria, R. AU - Driscoll, J. S. AU - Mitsuya, H. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 17 SP - 12633 EP - 12638 SN - 0021-9258 AD - Gao, W. Y.: (H. Mitsuya) Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006752. Publication Type: Journal Article. Language: English. KW - analogues KW - Biochemistry KW - human immunodeficiency viruses KW - Metabolism KW - nucleoside analogues KW - nucleosides KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - analogs KW - HUMAN IMMUNODEFICIENCY VIRUS KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006752&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of phosphorylation and nucleotides on the conformation of myosin II from Acanthamoeba castellanii. AU - Redowicz, M. J. AU - Martin, B. AU - Zolkiewski, M. AU - Ginsburg, A. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 18 SP - 13558 EP - 13563 SN - 0021-9258 AD - Redowicz, M. J.: Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803490. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activity of filamentous Acanthamoeba castellanii myosin II is inactivated by phosphorylation of a short non-helical tailpiece at the C-terminal end of each heavy chain, even though the catalytic sites are in the N-terminal globular head. Consistent with this effect, phosphorylation at the tip of the tail alters the conformation of the head, as shown by a shift in the principal site of cleavage by endoproteinase Arg-C. It was shown that the sedimentation coefficient of monomeric phospho-myosin II is 1.3-4.6% lower than that of dephospho-myosin II, which suggests that phosphorylation produces a less compact conformation with a small increase in frictional coefficient. Changes in papain digestion patterns showed that bound nucleotide also affects the conformation of the head region of monomeric phospho- and dephospho-myosin II, the conformation of the head region of filamentous phospho- and dephospho-myosin II, and the conformation of the C-terminal region of the tail of filamentous phospho-myosin II. Conformational differences between the dephospho- and phospho-forms of myosin II in the presence of nucleotide, as detected by susceptibility to proteolysis appear to be greater in filaments than in monomers. These results provide additional evidence for communication between the N-terminal heads and C-terminal tails of Acanthamoeba myosin II. KW - biochemistry KW - myosins KW - nucleotides KW - parasites KW - phosphorylation KW - proteins KW - Acanthamoeba castellanii KW - Acanthamoebidae KW - protozoa KW - Sarcomastigophora KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803490&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparumS-adenosylhomocysteine hydrolase: cDNA identification, predicted protein sequence, and expression in Escherichia coli. AU - Creedon, K. A. AU - Rathod, P. K. AU - Wellems, T. E. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 23 SP - 16364 EP - 16370 SN - 0021-9258 AD - Creedon, K. A.: Laboratory of Malaria Research, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950809088. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Subject Subsets: Protozoology N2 - Compounds that specifically inhibit S-adenosylhomocysteine hydrolase (SAHH; EC 3.3.1.1) interfere with the proliferation of Plasmodium falciparum but efforts to identify the enzyme directly in parasite extracts have been unsuccessful. Genetic and biochemical evidence is presented for the presence of a gene encoding P. falciparum SAHH. The gene was transcribed as a 2.8 kilobase mRNA in erythrocytic stage parasites. Analysis of the open reading frame predicted a 53 900 MW protein having conserved regions thought to be involved in NAD binding. The cDNA sequence was incorporated into an Escherichia coli expression construct to confirm the function of the sahh product. Transformed E. coli cells produced a protein with a relative molecular weight of 56 000 which possessed SAHH activity, as evidenced by the conversion of 3-deazaadenosine to S-3-deazaadenosylhomocysteine. Several amino acid residues that have been suggested to be at the SAHH active site in other organisms show nonconserved replacements in P. falciparum, suggesting that some current proposals for the enzyme mechanism may need to be revised. Structural differences between P. falciparum and mammalian SAHH enzymes may foster innovative strategies for antimalarial drug development. KW - biochemistry KW - complementary dna KW - enzyme inhibitors KW - enzymes KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - adenosylhomocysteine hydrolase KW - biochemical genetics KW - cDNA KW - DNA sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809088&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease. AU - Wondrak, E. M. AU - Sakaguchi, K. AU - Rice, W. G. AU - Kun, E. AU - Kimmel, A. R. AU - Louis, J. M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 35 SP - 21948 EP - 21950 SN - 0021-9258 AD - Wondrak, E. M.: (J.M. Louis) Building 6, Room B1-16, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952000148. Publication Type: Journal Article. Language: English. KW - biochemistry KW - human immunodeficiency viruses KW - molecular biology KW - nucleocapsid proteins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - protease cleavage KW - protein processing KW - zinc finger domain KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The collagen binding domain of fibronectin contains a high affinity binding site for Candida albicans. AU - Nègre, E. AU - Vogel, T. AU - Levanon, A. AU - Guy, R. AU - Walsh, T. J. AU - Roberts, D. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 35 SP - 22039 EP - 22045 SN - 0021-9258 AD - Nègre, E.: Laboratory of Pathology and Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951203147. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A 30-kDa proteolytic fragment from the gelatin/collagen binding domain of fibronectin was a potent inhibitor of fibronectin binding to C. albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin-I and the heparin II-binding domains also inhibited fibronectin binding but were 13- to 1000-fold less active. In suspension, binding of fibronectin to C. albicans was regulated by growth conditions and is specific, saturable, time-dependent, reversible and divalent cation-independent. Scatchard-plot analyses indicated the presence of high affinity (Kd=1.3 × 10-9M) and low affinity (Kd=1.2 × 10-7M) receptors. Recombinant or proteolytic fragments from 4 binding domains of fibronectin promoted adhesion of C. albicans. A recombinant fragment corresponding to the cell-binding domain but with the sequence Arg-Gly-Asp-Ser deleted promoted C. albicans adhesion and inhibited fibronectin binding to C. albicans with the same activity as the natural sequence. Four peptides containing the Arg-Gly-Asp sequence and the peptides CS-1 and Arg-Glu-Asp-Val did not block the binding of fibronectin to C. albicans. It is suggested that, in contrast to the specific binding of soluble fibronectin, recognition of immobilized fibronectin by C. albicans is mediated by several domains of the protein. Interactions with the cell-binding domain are not mediated by the Arg-Gly-Asp or other known recognition sequences. Binding of fibronectin did not correlate with C3d binding to the avirulent clones of C. albicans strain H12 or with iC3b binding to variants of the strain 4918. KW - adhesion KW - fibronectins KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203147&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. AU - Kruth, H. S. AU - Skarlatos, S. I. AU - Gaynor, P. M. AU - Gamble, W. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 39 SP - 24511 EP - 24518 SN - 0021-9258 AD - Kruth, H. S.: Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951413329. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Atherosclerotic lesions have a lipid core containing crystals and liposomes enriched in unesterified cholesterol as well as numerous monocyte-macrophages enriched in cholesteryl ester. Sufficient amounts of plasma-derived HDL may not reach and efficiently remove the cholesterol deposited in lesion macrophages or in the lipid core of lesions. The potential of human monocyte-macrophages to produce nascent HDL and to solubilize cholesterol derived from interaction of monocyte-macrophages with lipoprotein and non-lipoprotein sources of cholesterol was examined. Monocyte-macrophages produced discoidal (25±6 nm long and 6±1 nm wide (mean±s.d.)) and vesicular (89±41 nm in diameter) lipoprotein particles following and during enrichment of macrophages with cholesterol from acetylated LDL (AcLDL) or cholesterol crystals. During cholesterol enrichment, discoidal particles progressively accumulated in the medium for up to 6 days. In contrast, vesicles did not increase past 2 days of incubation. Both the discoidal and vesicular lipoprotein particles had a peak density of about 1.09-1.10 g/ml. The discoidal particles contained apolipoprotein E (apoE), whereas vesicles contained a major protein constituent with a molecular mass of 22 000 daltons. The vesicles did not contain detectable apoE and the 22 000-dalton protein was not the 22 000-dalton thrombolytic fragment of apoE. Following cholesterol enrichment of macrophages with AcLDL or cholesterol crystals, macrophages excreted much of their accumulated cholesterol, even in the absence of exogenously added cholesterol acceptors. Most of this excreted cholesterol was recovered from the culture medium and was carried in the apoE discoidal particles that showed cholesterol enrichment up to a 2:1 unesterified cholesterol to phospholipid molar ratio. Findings suggest that sufficient production of these nascent HDL by macrophages within atherosclerotic lesions should facilitate removal of cellular and extracellular cholesterol, even in the absence of plasma-derived HDL. KW - cell cultures KW - cholesterol KW - high density lipoprotein KW - macrophages KW - synthesis KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413329&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The influence of DNA and nucleosome structure on integration events directed by HIV integrase. AU - Pruss, D. AU - Reeves, R. AU - Bushman, F. D. AU - Wolffe, A. P. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 40 SP - 25031 EP - 25041 SN - 0021-9258 AD - Pruss, D.: Laboratory of Molecular Embryology, NICHHD, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002108. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Registry Number: 9007-49-2. KW - DNA KW - histones KW - human diseases KW - human immunodeficiency viruses KW - integration KW - molecular biology KW - structure KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - integrase KW - nucleosome KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002108&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase. AU - Hickman, A. B. AU - Palmer, I. AU - Engelman, A. AU - Craigie, R. AU - Wingfield, P. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1994/// VL - 269 IS - 46 SP - 29279 EP - 29287 SN - 0021-9258 AD - Hickman, A. B.: Office of the Director, Protein Expression Laboratory National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002117. Publication Type: Journal Article. Language: English. Number of References: 66 ref. KW - catalytic activity KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - mutations KW - structure KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. AU - Clerici, M. AU - Levin, J. M. AU - et al. AU - Kessler, H. A. ( AU - Shearer, G. M. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 271 IS - 1 SP - 42 EP - 46 SN - 0098-7484 AD - Clerici, M.: (G.M. Shearer) National Cancer Institute, National Institutes of Health, Experimental Immunology Branch, Building 10, Room 4B17, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005341. Publication Type: Journal Article. Language: English. KW - cell mediated immunity KW - Health care workers KW - HIV infections KW - Immune response KW - Immunology KW - T lymphocytes KW - cellular immunity KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Percutaneous exposure KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005341&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ocular toxoplasmosis: an old disease revisited. AU - Nussenblatt, R. B. AU - Belfort, R., Jr. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 271 IS - 4 SP - 304 EP - 305 SN - 0098-7484 AD - Nussenblatt, R. B.: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19950809265. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology N2 - A general account of the clinical manifestations and diagnosis of ocular toxoplasmosis is given, with details of 2 selected cases (a 2-year-old Brazilian infant and a 20-year-old American man). It is emphasized that in immunodeficient patients the signs of ocular toxoplasmosis can be similar to those noted in immunocompetent patients, although multiple active lesions may be seen in both eyes which is rarely seen in patients that are not immunosuppressed. In patients with the acquired immune deficiency syndrome (AIDS), the development of ocular toxoplasmosis usually occurs before cytomegalovirus (CMV) retinitis. Exacerbations of the ocular disease are not predictable, although they are more frequent in the years immediately following the first episode and then occur less commonly with time. KW - case reports KW - diagnosis KW - eye diseases KW - eyes KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - pathology KW - reviews KW - symptoms KW - toxoplasmosis KW - Brazil KW - USA KW - cytomegalovirus KW - man KW - protozoa KW - Toxoplasma gondii KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809265&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HIV-2 transmission: implications for spread of HIV-1. AU - O'Brien, T. R. T2 - JAMA, Journal of the American Medical Association JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 271 IS - 12 SP - 903 EP - 904 SN - 0098-7484 AD - O'Brien, T. R.: National Cancer Institute, Rockville, Maryland, USA. N1 - Accession Number: 19942006764. Publication Type: Correspondence. Language: English. KW - Epidemiology KW - HIV infections KW - Infectivity KW - Sexual transmission KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus infections KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006764&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body mass index, weight change and risk of mobility disability in middle-aged and older women. The epidemiologic follow-up study of NHANES I. AU - Launer, L. J. AU - Harris, T. AU - Rumpel, C. AU - Madans, J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 271 IS - 14 SP - 1091 EP - 1098 SN - 0098-7484 AD - Launer, L. J.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, 7201 Wisconsin Ave., Gateway Bldg 3C-309, Bethesda, MD 20892, USA. N1 - Accession Number: 19951403587. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - The relation between body mass index (BMI), weight change and the onset of disability in older women was studied. White women were classified as young-old (mean age 60 years at baseline, mean age 65 years at follow-up) and old-old (mean age 76 years at baseline, mean age 80 years at follow-up). The main outcome measures were the relative odds for the onset of mobility disability associated with tertiles of past BMI (measured 6-8 years prior to disability ascertainment) and current BMI (measured 2-5 years prior to disability ascertainment) and with weight change between the 2 weight measurements. The prospective data suggested that high BMI is a strong predictor of long-term risk for mobility disability in older women and that this risk persists even to very old age. However, the paradoxical increase in risk associated with weight loss observed in the old-old women requires further study. Programmes to prevent overweight may have potential for decreasing disability in women. KW - age KW - body weight KW - disabilities KW - middle age KW - old age KW - overweight KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403587&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helicobacter pylori in peptic ulcer disease. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 272 IS - 1 SP - 65 EP - 69 SN - 0098-7484 AD - Office of Medical Applications of Research, Federal Building, Room 618, National Institutes of Health, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19962004195. Publication Type: Journal Article; Conference paper; Journal article. Corporate Author: NIH Consensus Development Panel on Helicobacter pylori in Peptide Ulcer Disease. Language: English. N2 - The National Institutes of Health Consensus Development Conference on Helicobacter pylori in Peptic Ulcer Disease brought together specialists on gastroenterology, surgery, infectious diseases, epidemiology, and pathology, as well as the public to address the following questions: (1) What is the causal relationship of H. pylori to upper gastrointestinal disease? (2) How does one diagnose and eradicate H. pylori infection? (3) Does eradication of H. pylori infection benefit the patient with peptic ulcer disease? (4) What is the relationship between H. pylori infection and gastric malignancy? (5) Which H. pylori-infected patients should be treated? (6) What are the most important questions that must be addressed by future research in H. pylori infections? Following 11/2 days of presentations by experts and discussion by the audience, a consensus panel weighted the evidence and prepared their consensus statement. Among their findings, the consensus panel concluded that (1) ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to antisecretory drugs whether on first presentation with the illness or on recurrence; (2) the value of treating of non-ulcerative dyspepsia patients with H. pylori infection remains to be determined; and (3) the interesting relationship between H. pylori infection and gastric cancers requires further exploration. KW - human diseases KW - infections KW - peptic ulcers KW - Helicobacter pylori KW - man KW - Helicobacter KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004195&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Weight cycling. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 272 IS - 15 SP - 1196 EP - 1201 SN - 0098-7484 AD - Division of Digestive Diseases and Nutrition, National Institutes of Health, Bldg 31, Room 9A23, Bethesda, MD 20892, USA. N1 - Accession Number: 19951408255. Publication Type: Journal Article. Corporate Author: USA, National Task Force on the Prevention and Treatment of Obesity Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - A metaanalysis of weight cycling, "yo-yo dieting" and weight fluctuation was undertaken and led to the following conclusions. There is no convincing evidence that weight cycling in man has adverse effects on body composition, energy expenditure, risk factors for cardiovascular disease, or the effectiveness of future efforts at weight loss. Evidence regarding increased morbidity and mortality with variation in body weight is not sufficiently compelling to override the potential benefits of moderate weight loss in significantly obese patients. Determination of the psychological impact of weight cycling requires further investigation. Non-obese individuals should focus on preventing of weight gain by means of exercise and appropriate diet. Obese individuals who undertake weight loss efforts should be ready to commit themselves to lifelong changes in lifestyle and diet. KW - body weight KW - cycling KW - health KW - obesity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - metaanalysis KW - nutrient cycling KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408255&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Survival and disease progression according to gender of patients with HIV infection. The Terry Beirn Community Programs for clinical research on AIDS. AU - Melnick, S. L. AU - Sherer, R. AU - Louis, T. A. AU - Hillman, D. AU - Rodriguez, E. M. AU - Lackman, C. AU - Capps, L. AU - Brown, L. S. Jr AU - Carlyn, M. AU - Korvick, J. A. AU - Deyton, L. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1994/// VL - 272 IS - 24 SP - 1915 EP - 1921 SN - 0098-7484 AD - Melnick, S. L.: Epidemiology Branch, Division of AIDS, National Institutes of Health, 6003 Executive Blvd, Room 2C09, MSC 7620, Bethesda, MD 20892-7620, USA. N1 - Accession Number: 19952008213. Publication Type: Journal Article. Language: English. Number of References: 46 ref. KW - disease course KW - gender relations KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mortality KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - death rate KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Insulin stimulation of glucose transport activity in rat skeletal muscle: increase in cell surface GLUT4 as assessed by photolabelling. AU - Wilson, C. M. AU - Cushman, S. W. JO - Biochemical Journal (London) JF - Biochemical Journal (London) Y1 - 1994/// VL - 299 IS - 3 SP - 755 EP - 759 SN - 0264-6021 AD - Wilson, C. M.: Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951406682. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 50-99-7, 9004-10-8. Subject Subsets: Human Nutrition N2 - A photoaffinity label was used to quantify cell surface GLUT4 glucose transporters in isolated rat soleus muscles. In this system, insulin stimulated an 8.6-fold increase in 3-O-methylglucose glucose transport, while photolabelled GLUT4 increased 8-fold. These results demonstrate that the insulin-stimulated increase in glucose transport activity in skeletal muscle can be accounted for by an increase in surface-accessible GLUT4 content. KW - glucose KW - insulin KW - metabolism KW - skeletal muscle KW - transport KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dextrose KW - transportation KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low cholesterol concentrations and severe depressive symptoms in elderly people. AU - Brown, S. L. AU - Salive, M. E. AU - Harris, T. B. AU - Simonsick, E. M. AU - Guralnik, J. M. AU - Kohout, F. J. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1994/// VL - 308 IS - 6940 SP - 1328 EP - 1332 SN - 0959-8138 AD - Brown, S. L.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA. N1 - Accession Number: 19951405957. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The reported association between low serum cholesterol concentration and severe depressive symptoms was examined in 3939 men and women ≥71 years old. All analyses were stratified by sex, and multivariate analyses were adjusted for age, self-reported health, physical function, number of drugs used and weight loss. The score of depressive symptoms on the Centers for Epidemiologic Studies' depression scale was used to quantify depression. Depressive symptoms, cholesterol concentration, weight and use of drugs were all associated with age in men and women. The relative odds of severe depressive symptoms (score ≥16) for those with low cholesterol concentrations (<4.14 mmol/litre) were 1.9 (95% confidence interval 1.1 to 3.3) for the older group of men and 1.8 (1.1 to 2.9) for the older group of women. This association was also observed when depressive symptoms were analysed as a continuous rather than a categorical variable. In multivariate models that adjusted for age, self-reported health, physical function, number of drugs used and weight loss, the association was substantially weakened. After several factors relating to health had been controlled for, no significant association between low cholesterol concentration and severe depressive symptoms was found. KW - blood KW - cholesterol KW - depression KW - drug therapy KW - health KW - mental disorders KW - old age KW - weight losses KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - mental illness KW - psychiatric disorders KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405957&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Accumulation of fatty alcohol in MCF-7 breast cancer cells. AU - Welsh, C. J. AU - Robinson, M. AU - Warne, T. R. AU - Pierce, J. H. AU - Yeh, G. C. AU - Phang, J. M. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1994/// VL - 315 IS - 1 SP - 41 EP - 47 SN - 0003-9861 AD - Welsh, C. J.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. N1 - Accession Number: 19950400097. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Dairy Science KW - epithelium KW - fatty alcohols KW - mammary gland neoplasms KW - mammary glands KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - Human Physiology and Biochemistry (VV050) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400097&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli. AU - Tipper, J. P. AU - Citron, B. A. AU - Ribeiro, P. AU - Kaufman, S. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1994/// VL - 315 IS - 2 SP - 445 EP - 453 SN - 0003-9861 AD - Tipper, J. P.: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950103118. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9037-21-2. Subject Subsets: Agricultural Biotechnology N2 - Tryptophan hydroxylase was cloned from rabbit and human, and expressed in Escherichia coli (EMBL/GenBank accession number L29305 and L29306 respectively). Each of the cDNAs, including the complete coding sequence of tryptophan hydroxylase, was obtained by reverse transcription of rabbit or human brain mRNA and subcloned into the expression vector pET-3C. The expressed rabbit brain tryptophan hydroxylase activity, measured in the presence of tetrahydrobiopterin, represents approximately a 50-fold enhancement in yield (units/g tissue (wet wt)) over that of a rabbit brain extract. The level of expressed human brain tryptophan hydroxylase was approximately 57-fold the average yield previously reported for a human brain homogenate and approximately 10-fold the activity of homogenates of human raphe nucleus. The rabbit brain and pineal-derived tryptophan hydroxylase sequences varied by disparities in 6 amino acid residues (99% identity). The human carcinoid and brain peptide sequences varied by disparities in 18 amino acid residues (96% identity). Several properties of both expressed enzymes were studied and compared with those of native tryptophan hydroxylases. KW - biotechnology KW - brain KW - gene expression KW - nucleotide sequences KW - tryptophan 5-monooxygenase KW - Escherichia coli KW - man KW - rabbits KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - bacterium KW - cerebrum KW - cloning KW - DNA sequences KW - E. coli KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950103118&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Interferon therapy for chronic viral hepatitis. AU - Bisceglie, A. M. di T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1994/// VL - 330 IS - 2 SP - 137 EP - 138 SN - 0028-4793 AD - Bisceglie, A. M. di: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005889. Publication Type: Editorial. Language: English. Number of References: 10 ref. Registry Number: 9008-11-1. KW - editorials KW - hepatitis KW - human diseases KW - immunotherapy KW - interferon KW - viral diseases KW - viral hepatitis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005889&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection. AU - Abrams, D. I. AU - Goldman, A. I. AU - et al. AU - Launer, C. ( AU - Deyton, L.\Saag, M. S. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1994/// VL - 330 IS - 10 SP - 657 EP - 662 SN - 0028-4793 AD - Abrams, D. I.: (L. Deyton) National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005816. Publication Type: Journal Article. Corporate Author: USA, Terry Beirn Community Programs for Clincal Research on AIDS Language: English. Registry Number: 30516-87-1. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Clinical aspects KW - HIV infections KW - Treatment KW - Zidovudine KW - AIDS KW - AZT KW - clinical picture KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005816&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Declining age at HIV infection in the United States. AU - Rosenberg, P. S. AU - Biggar, R. J. AU - Goedert, J. J. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1994/// VL - 330 IS - 11 SP - 789 EP - 789 SN - 0028-4793 AD - Rosenberg, P. S.: National Cancer Institute, Rockville, MD 20892, USA. N1 - Accession Number: 19942005819. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health N2 - Analysis by "back-calculation" of data on the incidence of AIDS in the USA through 1991 showed that the total number of new infections declined from peak levels in the mid-1980s to about 50 000-60 000 new infections per year from 1987-91. The estimated median age at time of infection declined from more than 30 years in the early 1980s to 25 years from 1987-91. During this latter period 1 of every 4 people newly infected with HIV was younger than 22.Hilary Richardson KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Age KW - age determination KW - Epidemiology KW - HIV infections KW - human immunodeficiency viruses KW - infections KW - North America KW - USA KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - Human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. AU - Klahr, S. AU - Levey, A. S. AU - Beck, G. J. AU - Caggiula, A. W. AU - Hunsicker, L. AU - Kusek, J. W. AU - Striker, G. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1994/// VL - 330 IS - 13 SP - 877 EP - 884 SN - 0028-4793 AD - Klahr, S.: National Instittue of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19951406382. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. This was investigated in 840 patients with various chronic renal diseases. In study 1, 585 patients with glomerular filtration rates of 25 to 55 ml min-1 1.73 m-2 of body-surface area were randomly assigned to a usual-protein diet or a low-protein diet (protein 1.3 or 0.58 g/kg body weight daily) and to a usual- or a low-blood-pressure group (mean arterial pressure, 107 or 92 mm Hg). In study 2, 255 patients with glomerular filtration rates of 13 to 24 were randomly assigned to the low-protein diet (0.58 g/kg daily) or a very-low-protein diet (0.28 g/kg daily) with a keto acid-amino acid supplement and a usual- or a low-blood-pressure group (same values as those in study 1). An 18-to-45-month follow-up was planned, with monthly evaluations of the patients. The mean follow-up was 2.2 years. In study 1, the projected mean decline in the glomerular filtration rate at 3 years did not differ significantly between the diet groups or between the blood-pressure groups. As compared with the usual-protein group and the usual-blood-pressure group, the low-protein group and the low-blood-pressure group had a more rapid decline in the glomerular filtration rate during the first 4 months after randomization and a slower decline thereafter. In study 2, the very-low-protein group had a marginally slower decline in the glomerular filtration rate than did the low-protein group (P=0.07). There was no delay in the time to the occurrence of end-stage renal disease or death. In both studies, patients in the low-blood-pressure group who had more pronounced proteinuria at base line had a significantly slower rate of decline in the glomerular filtration rate. Among patients with moderate renal insufficiency, the slower decline in renal function that started 4 months after the introduction of a low-protein diet suggests a small benefit of this dietary intervention. Among patients with more severe renal insufficiency, a very-low-protein diet, as compared with a low-protein diet, did not significantly slow the progression of renal disease. KW - blood pressure KW - control KW - inhibition KW - kidney diseases KW - protein deprivation KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - kidney disorders KW - nephropathy KW - renal diseases KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Elucidation of the poly-L-proline binding site in Acanthamoeba profilin I by NMR spectroscopy. AU - Archer, S. J. AU - Vinson, V. K. AU - Pollard, T. D. AU - Torchia, D. A. JO - FEBS Letters JF - FEBS Letters Y1 - 1994/// VL - 337 IS - 2 SP - 145 EP - 151 SN - 0014-5793 AD - Archer, S. J.: Bone Research Branch, Building 30, Room 106, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950801113. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology N2 - The multifunctional protein profilin is thought to regulate actin assembly and the phosphoinositide signaling pathway. Profilin binds to several different ligands including actin, poly-L-proline, and the head groups of polyphosphoinositides. As a preliminary step in the characterization of profilin/ligand complexes, a profilin/poly-L-proline complex in solution was studied using high resolution nuclear magnetic resonance spectroscopy. Analysis of profilin nuclear Overhauser effects and chemical shift data indicated that the protein secondary structure was conserved upon binding to poly-L-proline and that the binding site was located between the N- and C-terminal helices in a region rich in highly conserved aromatic side chains. This site is adjacent to the proposed binding site for actin. In addition, the rate constant for dissociation of the complex was found to be 1.6 ± 0.2 x 104/second. KW - BINDING SITES KW - biochemistry KW - nuclear magnetic resonance KW - parasites KW - proteins KW - Acanthamoeba KW - protozoa KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - binding site KW - polyprolines KW - profilins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801113&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic analysis of Creutzfeldt-Jakob disease and related disorders. AU - Goldfarb, L. G. AU - Brown, P. AU - Cervenakova, L. AU - Gajdusek, D. C. JO - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences JF - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Y1 - 1994/// VL - 343 IS - 1306 SP - 379 EP - 384 SN - 0962-8436 AD - Goldfarb, L. G.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19942027999. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases N2 - Genetic studies of over 200 cases of Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru have brought a reliable body of evidence that the familial forms of CJD and all known cases of GSS and FFI are linked to germline mutations in the coding region of the PRNP [normal host prion protein] gene on chromosome 20, either point substitutions or expansion of the number of 24-nucleotide repeat units. Phenotypic expression of FFI and familial CJD, clinically and pathologically distinct syndromes linked to the 178Asp->Asn substitution, is dependent on a polymorphism at codon 129. Synthetic peptides homologous to several regions of PrP spontaneously form insoluble amyloid fibrils with unique morphological characteristics and polymerization tendencies. Peptides homologous to mutated regions of PrP exhibit enhanced fibrillogenic properties and, if mixed with the wild-type peptide, produce even more abundant and larger fibrous aggregates. A similar process in vivo may be the primary event leading to amyloid accumulation and disease. AS KW - Creutzfeldt-Jakob disease KW - molecular genetics KW - biochemical genetics KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027999&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term effect of prenatal exposure to maternal microfilaraemia on immune responsiveness to filarial parasite antigens. AU - Steel, C. AU - Guinea, A. AU - McCarthy, J. S. AU - Ottesen, E. A. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 343 IS - 8902 SP - 890 EP - 893 SN - 0140-6736 AD - Steel, C.: Laboratory of Parasitic Diseases, Building 4 Room 126, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19952003192. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Tropical Diseases; Helminthology N2 - To identify long-term effects of prenatal exposure to maternal filarial-parasite infection, the authors assessed lymphocyte responses in 21 Polynesian children born 17-19 years previously to mothers diagnosed as being microfilaraemic or infection-free. All children lived on an island endemic for Wuchereria bancrofti filariasis but were free from infection at the time of study. While children (n = 10) of infection-free mothers responded vigorously to microfilarial antigen with lymphocyte proliferation, production of interleukin 2 (IL-2), IL-5, IL-10, granulocyte macrophage colony-stimulating factor (GM-CSF), and interferon γ (IFN-γ), cellular hyporesponsiveness was seen in children (n = 11) born to microfilaraemic mothers. The hyporesponsiveness appeared restricted to microfilarial antigens and did not extend to non-parasite antigens. These findings suggest that hyporesponsiveness resulted from in-utero acquisition of tolerance to microfilarial antigens in chronically-infected mothers. KW - antigens KW - children KW - filariasis KW - helminths KW - human diseases KW - infections KW - maternal immunity KW - parasites KW - Oceania KW - Polynesia KW - man KW - Nematoda KW - Onchocercidae KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Wuchereria KW - Onchocercidae KW - Oceania KW - Pacific Islands KW - antigenicity KW - immunogens KW - nematodes KW - newborn immunity KW - parasitic worms KW - Secernentea KW - Spirurida KW - vitelline immunity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003192&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Congenital anaemia after transplacental B19 parvovirus infection. AU - Brown, K. E. AU - Green, S. W. AU - Mayolo, J. A. de AU - Bellanti, J. A. AU - Smith, S. D. AU - Smith, T. J. AU - Young, N. S. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 343 IS - 8902 SP - 895 EP - 896 SN - 0140-6736 AD - Brown, K. E.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952002879. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health N2 - The authors report from Maryland, USA, 3 children with congenital anaemia after intrauterine infection with parvovirus B19. All the fetuses developed hydrops fetalis that was treated by blood transfusion. After delivery the infants had hypogammaglobulinaemia. In all 3, sera lacked B19 but viral DNA was found in bone marrow. All were treated with immunoglobulin. One child died and B19 was found in various tissues. In the other 2 cases, virus could no longer be detected after therapy but the patients remain persistently anaemic. Persistent B19 infection should be suspected in infants with congenital red-cell aplasia. KW - case reports KW - congenital infection KW - human diseases KW - infants KW - infections KW - neonates KW - Maryland KW - North America KW - USA KW - man KW - parvovirus B19 KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Parvovirus KW - Parvoviridae KW - ssDNA viruses KW - DNA viruses KW - viruses KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - newborn infants KW - prenatal infection KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002879&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tuberculosis in eastern Europe and the former Soviet Union: how concerned should we be? AU - Burns, D. N. AU - Gellert, G. A. AU - Crone, R. K. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 343 IS - 8911 SP - 1445 EP - 1446 SN - 0140-6736 AD - Burns, D. N.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19952001510. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - The authors review the changing incidence of tuberculosis (TB). Since the late 1980s the steady decline in TB began to level off and in many countries the trend was actually reversed. In eastern Europe this is thought to be a result of malnutrition, poor living conditions and inadequate supplies of antituberculosis drugs. Human immunodeficiency virus (HIV) may play a role in the future. In 1993 the WHO declared the resurgence of TB a global emergency and published new treatment guidelines. KW - disease prevalence KW - human diseases KW - risk factors KW - tuberculosis KW - Central europe KW - Europe KW - USSR KW - man KW - Mycobacterium tuberculosis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Europe KW - bacterium KW - Union of Soviet Socialist Republics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001510&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. AU - Straus, S. E. AU - Corey, L. AU - Burke, R. L. AU - Savarese, B. AU - Barnum, G. AU - Krause, P. R. AU - Kost, R. G. AU - Meier, J. L. AU - Sekulovich, R. AU - Adair, S. F. AU - Dekker, C. L. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 343 IS - 8911 SP - 1460 EP - 1463 SN - 0140-6736 AD - Straus, S. E.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N-228, Bethesda, MD 20892, USA. N1 - Accession Number: 19952001511. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Immunotherapy of chronic viral diseases with vaccines is an important but unproven concept. The authors investigated the effect of a vaccine containing recombinant glycoprotein D (gD2) of herpes simplex virus type 2 (HSV-2) on the frequency of symptomatic outbreaks in patients with genital herpes. 98 patients with documented genital herpes who reported 4-14 recurrences per year were enrolled in a double-blind, placebo-controlled trial. Subjects received injections of either 100 µg gD2 in alum or alum alone (placebo) at 0 and 2 months and recurrences were documented for 1 year. The vaccine was well tolerated. gD2 recipients reported fewer recurrences per month than placebo recipients (mean 0.42 [SE 0.05] vs. 0.55 [0.05]; P = 0.055), had fewer virologically confirmed recurrences per month (0.18 [0.03] vs. 0.28 [0.03]; P = 0.019), and had a lower median number of recurrences for the study year (4 [range 0-17] vs. 6 [0-15]; P = 0.039). Neither genital recurrences not the placebo vaccine had any discernible effect on HSV-2-specific antibody responses, but gD2 vaccine boosted neutralizing antibodies to HSV-2 fourfold and gD2-specific titres sevenfold over baseline levels. These results inspire optimism about the potential use of vaccine for the treatment of chronic, recurring viral diseases. KW - clinical trials KW - human diseases KW - immunization KW - immunotherapy KW - recombinant vaccines KW - North America KW - USA KW - Human herpesvirus 2 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - herpes simplex virus 2 KW - immune sensitization KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001511&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High incidence of anal cancer among AIDS patients. AU - Melbye, M. AU - Coté, T. R. AU - Kessler, L. AU - Gail, M. AU - Biggar,R. J. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 343 IS - Mar. 12 SP - 636 EP - 639 SN - 0140-6736 AD - Melbye, M.: (T.R. Coté) Viral Epidemiology Branch, National Cancer Institute (NCI), EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19942005812. Publication Type: Journal Article. Corporate Author: USA, AIDS/Cancer Working Group Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - anus KW - Epidemiology KW - homosexuality KW - men KW - neoplasms KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cancers KW - homosexuals KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - PCP prophylaxis in paediatric HIV infection: time for a change? AU - Kovacs, J. A. AU - Kovacs, A. A. S. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1994/// VL - 344 IS - July 2 SP - 5 EP - 6 SN - 0140-6736 AD - Kovacs, J. A.: Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19942006936. Publication Type: Journal Article. Language: English. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - Clinical aspects KW - HIV infections KW - Paediatrics KW - Pneumocystis carinii pneumonia KW - Prophylaxis KW - AIDS KW - clinical picture KW - human immunodeficiency virus infections KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006936&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. AU - Warburg, A. AU - Saraiva, E. AU - Lanzaro, G. C. AU - Titus, R. G. AU - Neva, F. JO - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences JF - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Y1 - 1994/// VL - 345 IS - 1312 SP - 223 EP - 230 SN - 0962-8436 AD - Warburg, A.: Laboratory of Malaria Research and Laboratory of Parasitic Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19950503627. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Leishmania donovani chagasi [L. infantum chagasi] parasites, transmitted by sandflies of the Lutzomyia longipalpis species complex, normally cause visceral leishmaniasis. However, in Central America infections frequently result in cutaneous disease. Experiments were undertaken to investigate the possible influence of sandfly saliva on the course of infection in humans. Erythemas caused by feeding sandflies correlated well with the levels of the erythema-inducing peptide, maxadilan, in their saliva. Saliva of Brazilian flies was the most potent, that of Colombian flies less so, and Costa Rican saliva had very little maxadilan and lacked activity. Nucleotide sequence differences in the maxadilan gene of the 3 species were detected by 'single strand conformational polymorphism' electrophoresis. Leishmania infections proliferated fastest when coinjected with the saliva of Costa Rican flies. Brazilian flies had less influence, and Colombian flies only a slight effect. Thus Costa Rican Lutzomyia longipalpis, vectors of non-ulcerative cutaneous disease, have very low vasodilatory activity and very little maxadilan, but their saliva strongly enhances cutaneous proliferation of Leishmania infections. Conversely, flies from Colombia and Brazil, vectors of visceral disease, have more maxadilan, but exacerbate cutaneous infections to a lesser degree. These coincidental observations suggest that species of Lutzomyia longipalpis differ in their propensity to modulate the pathology of the disease they transmit. KW - biochemistry KW - cutaneous leishmaniasis KW - disease transmission KW - disease vectors KW - genes KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - saliva KW - sibling species KW - transmission KW - visceral leishmaniasis KW - Brazil KW - Colombia KW - Costa Rica KW - Diptera KW - Leishmania infantum KW - Leishmania infantum chagasi KW - Lutzomyia longipalpis KW - man KW - Phlebotominae KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Trypanosomatidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Leishmania infantum KW - Lutzomyia KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Andean Group KW - CACM KW - Central America KW - biochemical genetics KW - DNA sequences KW - maxadilan KW - salivary secretions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950503627&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Direct interaction of human TFIID with the HIV-1 transactivator Tat. AU - Kashanchi, F. AU - Piras, G. AU - et al. AU - Radonovich, M. F. ( JO - Nature (London) JF - Nature (London) Y1 - 1994/// VL - 367 SP - 295 EP - 299 SN - 0028-0836 AD - Kashanchi, F.: Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942005257. Publication Type: Journal Article. Language: English. KW - Gene expression KW - HIV infections KW - Molecular biology KW - Regulation KW - Transcription KW - Transcription factors KW - Activation KW - DNA transcription KW - human immunodeficiency virus infections KW - Tat KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005257&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HIV-1 infection of non-dividing cells. AU - Freed, E. O. AU - Martin, M. A. AU - Emerman, M.\Bukrinsky, M.\Stevenson, M. T2 - Nature (London) JO - Nature (London) JF - Nature (London) Y1 - 1994/// VL - 369 IS - May 12 SP - 107 EP - 108 SN - 0028-0836 AD - Freed, E. O.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19942027001. Publication Type: Correspondence. Language: English. KW - cellular biology KW - HIV infections KW - Infectivity KW - Macrophages KW - matrix proteins KW - Molecular biology KW - Pathogenesis KW - tropisms KW - vpr gene KW - cell biology KW - Cell infections KW - human immunodeficiency virus infections KW - Inactivated T lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942027001&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV. AU - Pantaleo, G. AU - Demarest, J. F. AU - et al. AU - Soudeyns, H. ( AU - Koup, R. A.\Ho, D. D.\Koup, R. A.\Ho, D. D. JO - Nature (London) JF - Nature (London) Y1 - 1994/// VL - 370 IS - Aug. 11 SP - 463 EP - 467 SN - 0028-0836 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19942006896. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - This paper reports that during the acute clinical syndrome often seen shortly after HIV infection the T-cell-mediated primary immune response is restricted to a set of variable domain Vβ families expressed in CD8+ cytotoxic T lymphocytes. Of great interest is the fact that the most dramatic Vβ expansion occurred in those patients who progressed to AIDS in the shortest time. The patient with the fastest progression time (among the 6 studied) was noted to be HLA-1 B8 which is known to be associated with rapid progression in severe cohort studies. [Further studies along these lines may help elucidate the exact nature and meaning of these interesting documentations. See also R.A. Koup and D.D. Ho (p. 416) for discussion of this work.] A.G. Dalgleish KW - acute course KW - CD8+ lymphocytes KW - Cytotoxic T lymphocytes KW - HIV infections KW - Immune response KW - Immunology KW - Seroconversion KW - T lymphocytes KW - CD8+ cells KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Oligoclonal expansion KW - severe course KW - T cells KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006896&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure. AU - Shahabuddin, M. AU - Rawlings, D. J. AU - Kaslow, D. C. JO - Biochimica et Biophysica Acta, Gene Structure and Expression JF - Biochimica et Biophysica Acta, Gene Structure and Expression Y1 - 1994/// VL - 1219 IS - 1 SP - 191 EP - 194 SN - 0167-4781 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, Building 4, Room B1-37, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950802865. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9001-40-5. Subject Subsets: Protozoology N2 - The structure of the Plasmodium falciparum-encoded glucose-6-phosphate dehydrogenase (PfG6PD) may provide clues about the relative protection against malaria in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Pfg6pd cDNA encoding a predicted 856 amino acid residues polypeptide with a calculated MW of >94 000 was cloned. The predicted amino acid sequence is highly homologous to G6PD from other organisms. Pfg6pd mapped as a single or low copy number gene to chromosome 14. The unusually large N-terminus and the distance between the NADP-binding site and G6PD-binding site is novel for the parasite G6PD. KW - amino acid sequences KW - complementary DNA KW - genes KW - glucose-6-phosphate dehydrogenase KW - human diseases KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - cDNA KW - DNA sequences KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802865&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Processing of dengue type 4 and other flavivirus nonstructural proteins. AU - Lai, C. J. AU - Pethel, M. AU - Jan, L. R. AU - Kawano, H. AU - Cahour, A. AU - Falgout, B. A2 - Brinton, M.A. A2 - Calisher, C.A. A2 - Rueckert, R. JO - Archives of Virology, Supplementum JF - Archives of Virology, Supplementum Y1 - 1994/// IS - 9 SP - 359 EP - 368 CY - Wien; Austria PB - Springer-Verlag SN - 0939-1983 SN - 3211825223\0387825223 AD - Lai, C. J.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940502523. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - Dengue type 4 (DEN4) and other flaviviruses employ host and viral proteases for polyprotein processing. Most proteolytic cleavages in the DEN4 nonstructural protein (NS) region are mediated by the viral NS2B-NS3 protease. The N-terminal third of NS3, containing sequences homologous to serine protease active sites, is the protease domain. To determine required sequences in NS2B, deletions were introduced into DEN4 NS2B-30%NS3 cDNA and the expressed polyproteins assayed for self-cleavage. A 40 amino acid segment within NS2B was essential. Sequence analysis of NS2B predicts that this segment constitutes a hydrophilic domain surrounded by hydrophobic regions. Hydrophobicity profiles of other flavivirus NS2Bs show similar patterns. Cleavage of DEN4 NS1-NS2A requires an octapeptide sequence at the NS1 C terminus and downstream NS2A. Comparison of the analogous octapeptide sequence among flaviviruses indicates a consensus cleavage sequence of (P8)Met/Leu-Val-Xaa-Ser-Xaa-Val-Ala(P1), where Xaa are nonconserved amino acids. The effects on cleavage of amino acid substitutions in this consensus sequence were analysed. Most substitutions of the conserved residues interfered with cleavage, whereas substitutions of non-conserved residues had little or no effect. These findings indicate that the responsible enzyme recognizes well-defined sequences at the cleavage site. KW - arboviruses KW - cleavage KW - processing KW - proteins KW - viral proteins KW - dengue virus KW - Flavivirus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - dengue virus type 4 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940502523&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biolistic techniques for transfection of mosquito embryos (Anopheles gambiae). AU - Mialhe, E. AU - Miller, L. H. JO - BioTechniques (Euro Edition) JF - BioTechniques (Euro Edition) Y1 - 1994/// IS - July/August SP - 54 EP - 61 SN - 0736-6205 AD - Mialhe, E.: Laboratory of Malaria Research, Building 4, Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950100409. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9007-49-2. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology N2 - With a view to increasing the rate of genetic transformation in mosquito embryos, 3 biolistic methods were evaluated: (1) dry biolistics, involving the delivery of dry DNA-coated particles using a commercially available instrument, PDS-1000/He; (2) high pressure biolistics, involving the delivery of an aqueous suspension of DNA-coated particles by PDS-1000/He at 450-650 psi helium pressure; and (3) low pressure biolistics, involving a different accelerator, firstly described for plant transformation, to deliver DNA-coated particles suspended in water. Expression levels of the delivered luciferase gene under the control of the Drosophila heat shock protein 70 promoter were low and highly variable in embryos transfected using the dry method. The level of gene expression increased 100-fold without significantly reducing embryo viability when either of the aqueous methods were used. KW - biolistics KW - biotechnology KW - direct DNA uptake KW - DNA KW - embryo culture KW - embryos KW - experimental equipment KW - gene expression KW - gene transfer KW - genetic engineering KW - genetic transformation KW - instrumentation KW - laboratory equipment KW - luciferases KW - reporter genes KW - techniques KW - transfection KW - viability KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - experimental rigs KW - genetic manipulation KW - luciferase KW - mosquitoes KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950100409&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immunology: the role of the parasite. AU - Nash, T. E. A2 - Thompson, R. C. A. A2 - Reynoldson, J. A. A2 - Lymbery, A. J. T2 - Giardia: from molecules to disease. Y1 - 1994/// CY - Wallingford; UK PB - CAB INTERNATIONAL SN - 0851988407 AD - Nash, T. E.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19940801788. Publication Type: Book chapter. Language: English. Number of References: 61 ref. Subject Subsets: Protozoology N2 - This chapter covers antigenic variation in Giardia with regard to biological significance and variant-specific surface proteins. KW - antigenic variation KW - giardiasis KW - human diseases KW - immunology KW - parasites KW - Giardia KW - Hexamitidae KW - protozoa KW - Sarcomastigophora KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - giardiosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940801788&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Regulation of gene expression during squamous differentiation by multiple retinoic acid signalling pathways. AU - Jetton, A. M. AU - Fujimoto, W. AU - Zhang, L. X. AU - Marvin, K. W. AU - Austin, S. AU - Mills, K. J. AU - Bernacki, S. H. AU - Saunders, N. A. A2 - Livrea, M. A. A2 - Vidali, G. T2 - Retinoids: from basic science to clinical applications. Y1 - 1994/// CY - Basel; Switzerland PB - Birkhäuser Verlag AG SN - 3764328126 AD - Jetton, A. M.: Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19941410255. Publication Type: Book chapter. Language: English. Number of References: 35 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - Evidence that the regulation of squamous differentiation is complex, differs among tissues, and involves a multiplicity of signalling pathways, is reviewed. Vitamin A deficiency induces squamous differentiation in several epithelia including tracheobronchial and uterine epithelia. Retinoids suppress expression in vitro of many squamous cell-specific genes, including involucrin, transglutaminase type 1, cornifin, cholesterol sulfotransferase, loricrin and several keratins. The effect of retinoic acid on the rate of transcription of these genes may be direct or indirect. Retinoids can alter gene expression at either the transcriptional or a post-transcriptional level. By using retinoids that selectively bind and activate RAR or RXR receptors, it was shown that different actions of retinoic acid can be mediated by specific nuclear retinoic acid receptors. KW - cell differentiation KW - retinoic acid KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cytodifferentiation KW - tretinoin KW - vitamin A acid KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410255&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Retinoid status, skin tumor formation and differentiation. AU - Luca, L. M. de AU - Celli, G. AU - Kosa, K. AU - Ross, S. AU - Chen, L. C. AU - Jones, C. AU - Grover, A. AU - Mitchell, S. AU - Darwiche, N. A2 - Livrea, M. A. A2 - Vidali, G. T2 - Retinoids: from basic science to clinical applications. Y1 - 1994/// CY - Basel; Switzerland PB - Birkhäuser Verlag AG SN - 3764328126 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19941410263. Publication Type: Book chapter. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - The interplay between retinoic acid deficiency and steroid hormones in the development of changes in various epithelia, including transformation of simple columnar epithelium, initially into pseudostratified epithelium, then into squamous stratified, and eventually into the keratinizing squamous stratified phenotype is examined. Results indicated down-regulation of retinoic acid receptor α specifically in skin carcinomas simultaneously with upregulation of retinoid X receptor α (RXRα). The elevated expression of RXRα in carcinomas suggested that certain nuclear signal transduction pathways requiring RXR to form dimers may be elevated because of the growth characteristics and metastatic potential of these cells. KW - neoplasms KW - nutritional state KW - retinoids KW - skin KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - dermis KW - nutritional status KW - vitamin A compounds KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410263&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Regulation of iron metabolism in eukaryotic cells. AU - Rouault, T. AU - Klausner, R. A2 - Favier, A. E. A2 - Neve, J. A2 - Faure, P. T2 - Trace elements and free radicals in oxidative diseases. Y1 - 1994/// CY - Champaign; USA PB - American Oil Chemists' Society SN - 0935315535 AD - Rouault, T.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951404106. Publication Type: Book chapter. Language: English. Number of References: 28 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - This review focusses on the function of 3 proteins that are critical in iron metabolism. These are: ferritin, a 24-subunit iron storage molecule; the transferrin receptor, a membrane receptor that mediates uptake of iron through binding to the serum iron carrier transferrin; and the iron-responsive element binding protein, a cytosolic protein that is involved in sensing iron levels and regulating expression of ferritin, the transferrin receptor, and possibly other genes including the enzyme that is rate-limiting in haem biosynthesis, δ-aminolaevulinate synthase. KW - iron KW - metabolism KW - reviews KW - eukaryotes KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Regulation of epithelial differentiation by retinoids. AU - Rosenthal, D. AU - Lancillotti, F. AU - Darwiche, N. AU - Sinha, R. AU - Luca, L. M. de A2 - Blomhoff, R. T2 - Vitamin A in health and disease. Y1 - 1994/// CY - New York; USA PB - Marcel Dekker, Inc. SN - 0824791207 AD - Rosenthal, D.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19941407762. Publication Type: Book chapter. Language: English. Number of References: 126 ref. Subject Subsets: Human Nutrition N2 - Regulation of epithelial differentiation by retinoids is reviewed under the headings: Control of epidermal differentiation by retinoic acid; Retinoid status controls the differentiation of the tracheal epithelium; Retinoids and the vaginal and cervical epithelium. KW - differentiation KW - epithelium KW - regulation KW - retinoids KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin A compounds KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407762&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Retinoylation of proteins in mammalian cells. AU - Takahashi, N. AU - Breitman, T. R. A2 - Blomhoff, R. T2 - Vitamin A in health and disease. Y1 - 1994/// CY - New York; USA PB - Marcel Dekker, Inc. SN - 0824791207 AD - Takahashi, N.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19941407747. Publication Type: Book chapter. Language: English. Number of References: 38 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - Retinoylation of proteins is reviewed under the headings: Retinoylation of nuclear protein in the human acute myeloid leukaemia cell line HL60; Retinoylation in cells with varied sensitivity to retinoic acid; Retinoylation of HL60 protein in the presence of cycloheximide; Labelling of HL60 cellular protein by [³H]palmitic acid (PA) and [³H]myristic acid (MA); Binding of retinoylated protein to DNA-cellulose; Identification of retinoylated proteins; and Retinoylation in fresh cells of patients with myeloid leukaemias. KW - antioxidants KW - cells KW - metabolism KW - modification KW - proteins KW - retinoic acid KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - tretinoin KW - vitamin A acid KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407747&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumococcal conjugate vaccines: review and update. AU - Klein, D. L. JO - Microbial Drug Resistance JF - Microbial Drug Resistance Y1 - 1995/// VL - 1 IS - 1 SP - 49 EP - 58 AD - Klein, D. L.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19952007851. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Public Health N2 - A review of the development of conjugate vaccines and their properties. KW - conjugate vaccines KW - human diseases KW - immunization KW - reviews KW - man KW - Streptococcus pneumoniae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Streptococcus KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - bacterium KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007851&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro. AU - Maciejewski, J. P. AU - Weichold, F. F. AU - Young, N. S. AU - Cara, A. AU - Zella, D. AU - Reitz, M. S., Jr. AU - Gallo, R. C. AU - Wainberg, M. A.\Gu, Z. X. JO - Nature Medicine JF - Nature Medicine Y1 - 1995/// VL - 1 IS - 7 SP - 667 EP - 673 AD - Maciejewski, J. P.: Hematology Branch, National Heart, Lung and Blood Institute, Building 10, Room 7C103, National Institutes of Health, Bethesda, MD 20892-1652, USA. N1 - Accession Number: 19952006281. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9068-38-6. Subject Subsets: Public Health N2 - As current treatments for HIV are unsatisfactory, gene therapy approaches have been adopted including the transfer of genes encoding antibody molecules, a strategy which is termed 'intracellular immunization'. Previous studies targeting gp120 and rev with this approach have shown that the binding of intracellular antibodies to these target proteins can alter the viral life cycle and can be used to inhibit infection. In this current paper the authors have used recombinant techniques to clone genes encoding for the variable regions of the heavy and light chains from murine hybridomas producing anti-reverse transcriptase (RTase) immunoglobulin. The main reason for selecting this target is that it should prevent HIV replication before viral integration into the host genome, therefore allowing the possible resolution of the infected state. In vitro the antibody rendered HIV-permissive cells resistant to infection, with protection being conferred against a wide range of clinical isolates and laboratory strains of both HIV-1 and HIV-2. Strongest inhibitory effects on HIV replication was observed in cell lines transduced with genes encoding for both the H and L chain fragments of anti-RTase, with some degree of HIV inhibition being seen in cultures transduced with H chain fragments only. Future studies are going to focus on the design of a single-chain monoclonal fragment, consisting of fused variable VH and VL chains. The authors concluded that if this could be done efficiently, this approach may be an effective anti-HIV therapy. [In spite of its efficacy against the multiple isolates tried, it remains a distinct possibility that if the treatment has to be given several times to peripheral lymphocytes resistance will inevitably occur.] A. Dalgleish KW - acquired immune deficiency syndrome KW - antibodies KW - combination therapy KW - drug therapy KW - gene therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - reverse transcriptase KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - combined modality therapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - intracellular immunization KW - multimodal treatment KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006281&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human retroviruses in the second decade: a personal perspective. AU - Gallo, R. C. JO - Nature Medicine JF - Nature Medicine Y1 - 1995/// VL - 1 IS - 8 SP - 753 EP - 759 AD - Gallo, R. C.: Laboratory of Tumour Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962003166. Publication Type: Journal Article. Language: English. Number of References: 56 ref. KW - acquired immune deficiency syndrome KW - gene expression KW - HIV infections KW - HTLV infections KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - molecular biology KW - pathogenesis KW - replication KW - research KW - retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003166&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. AU - Katayose, D. AU - Gudas, J. AU - Nguyen, H. AU - Srivastava, S. AU - Cowan, K. H. AU - Seth, P. JO - Clinical Cancer Research JF - Clinical Cancer Research Y1 - 1995/// VL - 1 IS - 8 SP - 889 EP - 897 AD - Katayose, D.: Medical Breast Cancer Section, Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950404799. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Dairy Science N2 - A recombinant adenovirus vector (E1 minus) expressing human wild-type p53 cDNA (AdWTp53) was constructed. Infection of normal and tumour cells of lung and mammary epithelial origin with AdWTp53 resulted in high values of wild-type p53 expression. Production of p53 protein following infection was dependent on the dose of AdWTp53. Maximum amounts of p53 were produced following infection with 50 p.f.u./cell. AdWTp53 infection inhibited the growth of all human cell lines studied. However, tumour cells that did not express p53 before infection (H-358 and MDA-MB-157) and tumour cells that expressed mutant endogenous p53 protein (MDA-MB-231 and MDA-MB-453) were more sensitive to AdWTp53 cytotoxicity than cells that contained the wild-type p53 (MCF-7, MCF-10, 184B5 and normal mammary epithelial cells). All cells showed WAF1/Cip1 mRNA and protein induction following AdWTp53 infection. AdWTp53-induced cytotoxicity of human tumour cell lines expressing mutant p53 was mediated by apoptosis as shown by nucleosomal DNA fragmentation analysis. No detectable nucleosomal DNA fragmentation was observed following AdWTp53 infection of human cells expressing wild-type p53. Data suggest that endogenous p53 status is a determinant of AdWTp53-mediated cell killing of human tumour cells. KW - cell cultures KW - cell lines KW - epithelium KW - gene expression KW - gene therapy KW - mammary gland neoplasms KW - mammary glands KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950404799&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line. AU - Oravecz, T. AU - Roderiquez, G. AU - Koffi, J. AU - Wang, J. AU - Ditto, M. AU - Bou-Habib, D. C. AU - Lusso, P. AU - Norcross, M. A. AU - Dalgleish, A. G. JO - Nature Medicine JF - Nature Medicine Y1 - 1995/// VL - 1 IS - 9 SP - 919 EP - 926 AD - Oravecz, T.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Building 29B, Room 4E12, HFM-541, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009565. Publication Type: Journal Article. Language: English. Number of References: 45 ref. KW - cellular biology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - markers KW - molecular biology KW - pathogenesis KW - tropisms KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD26 KW - cell biology KW - cell surfaces KW - cell tropism KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - monocytotropic viruses KW - viral entry KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009565&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of human tonsil histocultures: a model for HIV pathogenesis. AU - Glushakova, S. AU - Baibakov, B. AU - Margolis, L. B. AU - Zimmerberg, J. JO - Nature Medicine JF - Nature Medicine Y1 - 1995/// VL - 1 IS - 12 SP - 1320 EP - 1322 AD - Glushakova, S.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002922. Publication Type: Journal Article. Language: English. Number of References: 12 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - laboratory methods KW - lymphatic diseases KW - pathogenesis KW - tissue culture KW - tonsils KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - laboratory techniques KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002922&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Laboratory diagnosis of invasive fungal infections in patients with neoplastic diseases. AU - Walsh, T. J. AU - Lyman, C. A. AU - Pizzo, P. A. A2 - Meunier, F. T2 - Baillière's Clinical Infectious Diseases Y1 - 1995/// VL - 2 IS - 1 AD - Walsh, T. J.: Pediatric Branch, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951202886. Publication Type: Journal Article; Book chapter; Journal article. Language: English. Number of References: 219 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The laboratory diagnosis of invasive fungal infections in patients with neoplastic diseases is discussed, including principles of collection, transportation, storage and accession of specimens. Clinical manifestations of invasive Candida infection, direct examination and processing of specimens, detection and significance of fungaemia, histopathology, microbiological identification of Candida spp., differential diagnosis of other yeast isolates, investigational methods of non-culture diagnosis of invasive candidosis (detection of anti-Candida antibodies, detection of Candida antigens by immunoassay), amplification of Candida DNA by the polymerase chain reaction and antifungal susceptibility testing are discussed. Clinical and radiographic correlation in invasive Aspergillus infections, microbiology of aspergillosis, significance of positive Aspergillus spp. cultures and investigational immunodiagnostic, biochemical and molecular methods of diagnosis of invasive aspergillosis are also covered. The diagnosis of other opportunistic infections caused by agents of zygomycosis, Fusarium spp., Pseudallescheria boydii, Trichosporon, Cryptococcus neoformans, Histoplasma capsulatum, Coccidioides immitis and Penicillium spp., is also considered. KW - aspergillosis KW - candidosis KW - cryptococcosis KW - diagnosis KW - fusariosis KW - histoplasmosis KW - human diseases KW - immunocompromised hosts KW - infections KW - neoplasms KW - opportunistic infections KW - predisposition KW - pseudallescheriasis KW - reviews KW - zygomycosis KW - Aspergillus KW - Candida KW - Coccidioides immitis KW - Cryptococcus neoformans KW - Fusarium KW - Histoplasma capsulatum KW - man KW - Penicillium KW - Pseudallescheria boydii KW - Trichosporon KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Histoplasma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporonaceae KW - Ajellomyces capsulatus KW - cancers KW - candidiasis KW - european blastomycosis KW - fungus KW - fusarioses KW - Hyphomycetes KW - penicilliosis KW - phycomycosis KW - trichosporonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202886&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Highly conserved retroviral zinc fingers as targets for HIV-1 therapeutic management. AU - Rice, W. G. AU - Turpin, J. A. AU - Arthur, L. O. AU - Henderson, L. E. JO - International Antiviral News JF - International Antiviral News Y1 - 1995/// VL - 3 IS - 6 SP - 87 EP - 89 SN - 0965-2310 AD - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19952006215. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 52-90-4. KW - acquired immune deficiency syndrome KW - antiviral agents KW - chelating agents KW - cysteine KW - dna binding proteins KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - molecular biology KW - nucleocapsid proteins KW - nucleotide sequences KW - residues KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - DNA sequences KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - rational design KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006215&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Discovery and development of disulphide-substituted benzamides as candidate anti-HIV drugs. AU - Rice, W. G. AU - Arthur, L. O. AU - Henderson, L. E. AU - Turpin, J. A. JO - International Antiviral News JF - International Antiviral News Y1 - 1995/// VL - 4 IS - 1 SP - 03 EP - 06 SN - 0965-2310 AD - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, PO Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962002654. Publication Type: Journal Article. Language: English. Number of References: 6 ref. KW - antiviral agents KW - dna binding motifs KW - HIV infections KW - human diseases KW - Human immunodeficiency virus 1 KW - man KW - retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - benzamides KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002654&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Microsatellite DNA and isozyme variability in a West African population of Anopheles gambiae. AU - Lanzaro, G. C. AU - Zheng, L. AU - Touré, Y. T. AU - Traoré, S. F. AU - Kafatos, F. C. AU - Vernick, K. D. JO - Insect Molecular Biology JF - Insect Molecular Biology Y1 - 1995/// VL - 4 IS - 2 SP - 105 EP - 112 SN - 0962-1075 AD - Lanzaro, G. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950504547. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Microsatellites are defined as tracts of tandemly repeated short DNA sequences. Polymorphisms in this class of DNA are currently being used to generate a genetic map of A. gambiae. The potential of microsatellites as a tool for studying the genetic structure of natural populations of this mosquito were explored. Genetic polymorphism at 20 enzyme coding gene loci and 11 microsatellite DNA loci was surveyed in a population of A. gambiae from Mali. All of the microsatellite loci surveyed were polymorphic, as compared to 40% of the isozyme loci. The mean heterozygosity for the isozyme loci was only 0.097 (±0.0035), but for the microsatellite loci it was 0.732 (±0.060). The pattern of variability was very different between isozymes and microsatellites. Typically, at an isozyme locus a single allele occurred at a frequency ≥0.75, whereas at microsatellite loci the most common allele had a frequency <0.50. It was concluded that microsatellites provide a rich source of genetic polymorphisms for the study of the population genetics of A. gambiae and are in many ways superior to isozymes for this purpose. The potential for utilizing genetically mapped microsatellite loci to explore the effect of chromosomal inversions on the distribution of genetic polymorphisms in A. gambiae are discussed. KW - DNA KW - enzyme polymorphism KW - isoenzymes KW - molecular genetics KW - population genetics KW - Mali KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - ACP Countries KW - Francophone Africa KW - Africa KW - Least Developed Countries KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - biochemical genetics KW - deoxyribonucleic acid KW - isozymes KW - microsatellite DNA KW - mosquitoes KW - tandem repeats KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950504547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lyme disease (borreliosis): a global perspective. AU - Burgdorfer, W. JO - Alpe Adria Microbiology Journal JF - Alpe Adria Microbiology Journal Y1 - 1995/// VL - 4 IS - 4 SP - 227 EP - 233 SN - 1121-9750 AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, 903 South Fourth street, Hamilton, MT 59840, USA. N1 - Accession Number: 19960503177. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology KW - disease vectors KW - human diseases KW - Lyme disease KW - reviews KW - zoonoses KW - Borrelia burgdorferi KW - Ixodes KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodidae KW - Metastigmata KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - bacterium KW - lyme borreliosis KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503177&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum zinc, and serum lipid profiles in 778 adults. AU - Hiller, R. AU - Seigel, D. AU - Sperduto, R. D. AU - Blair, N. AU - Burton, T. C. AU - Farber, M. D. AU - Gragoudas, E. S. AU - Gunter, E. W. AU - Haller, J. AU - Seddon, J. M. AU - Sowell, A. L. AU - Yannuzzi, L. A. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1995/// VL - 5 IS - 6 SP - 490 EP - 496 SN - 1047-2797 AD - Hiller, R.: Division of Biometry and Epidemiology, National Eye Institute, Bethesda, MD 20892-2510, USA. N1 - Accession Number: 19961400734. Publication Type: Journal Article. Corporate Author: USA, Eye Disease Case-control Study Group Language: English. Number of References: 47 ref. Registry Number: 7440-66-6. Subject Subsets: Human Nutrition N2 - There has been increasing use of high-dosage zinc supplementation in the USA, in particular as a potential treatment for age-related macular degeneration. The relation between fasting serum Zn and serum lipid levels was examined in 778 adults 22 to 80 years old, who were control subjects in a multicentre, clinic-based case-control study. The samples were taken during 1987 to 1990, a time when vitamin/mineral supplementation was becoming increasingly common. Higher serum Zn levels, most notably those above the highest quintile, were associated with higher levels of total serum cholesterol, LDL cholesterol and triglycerides. No significant trend was noted for HDL cholesterol. Previous studies demonstrated that high-dosage Zn supplements raise serum Zn levels. The possibility that use of such supplements can adversely affect serum lipid profiles suggests that chronic ingestion of such supplements should not be done without adequate medical supervision. KW - blood KW - blood lipids KW - lipoproteins KW - supplements KW - zinc KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Human Nutrition (General) (VV100) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400734&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Coadaptation and immunodeficiency virus: lessons from the Felidae. AU - Carpenter, M. A. AU - O'Brien, S. J. JO - Current Opinion in Genetics & Development JF - Current Opinion in Genetics & Development Y1 - 1995/// VL - 5 IS - 6 SP - 739 EP - 745 SN - 0959-437X AD - Carpenter, M. A.: National Cancer Institute, Frederick, USA. N1 - Accession Number: 19962211138. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Veterinary Science N2 - The emergence of pathogenic viruses in new species offers an unusual opportunity to monitor the coadaptation of viruses and their hosts in a dynamic process of intense biological selection. Tracking lentivirus epidemics in man, monkeys and cats reveals genomic struggles at three levels: quasi-species divergence within an individual; coadaptation of virus and host genomes subsequent to disease outbreaks; and transmission, spread and pathogenesis in related host species. Aspects of each level are revealed by examining the genetic diversity of feline immunodeficiency virus in domestic and wild cat species. This approach has been facilitated by the recent genetic characterization of a novel lentivirus in lions. KW - acquired immune deficiency syndrome KW - evolution KW - cats KW - feline immunodeficiency virus KW - lentivirus KW - lions KW - man KW - Panthera KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Panthera KW - Homo KW - Hominidae KW - Primates KW - AIDS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962211138&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogeny and natural history of the primate lentiviruses, SIV and HIV. AU - Hirsch, V. M. AU - Dapolito, G. AU - Goeken, R. AU - Campbell, B. J. JO - Current Opinion in Genetics & Development JF - Current Opinion in Genetics & Development Y1 - 1995/// VL - 5 IS - 6 SP - 798 EP - 806 SN - 0959-437X AD - Hirsch, V. M.: National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 19962007016. Publication Type: Journal Article. Language: English. Number of References: 28 ref. KW - evolution KW - genetics KW - HIV infections KW - human immunodeficiency viruses KW - phylogeny KW - primates KW - simian immunodeficiency virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007016&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment and experimental therapeutics of blastomycosis. AU - St. Georgiev, V. JO - International Journal of Antimicrobial Agents JF - International Journal of Antimicrobial Agents Y1 - 1995/// VL - 6 IS - 1 SP - 1 EP - 12 SN - 0924-8579 AD - St. Georgiev, V.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19951203047. Publication Type: Journal Article. Language: English. Number of References: 182 ref. Registry Number: 1397-89-3, 86386-73-4, 65277-42-1, 22916-47-8. Subject Subsets: Medical & Veterinary Mycology N2 - The treatment and experimental therapeutics of blastomycosis are reviewed, including 2-hydroxystilbamidine, amphotericin B, azole derivatives (ketoconazole, fluconazole, miconazole, SCH 39304, ICI 195,739, Bay R 3783 and D0970) and fungal chitin synthase inhibitors (nikkomycins). The role of host defence mechanisms in inhibition of Blastomyces dermatitidis and the treatment of adult respiratory distress syndrome secondary to blastomycosis are also discussed. KW - amphotericin B KW - antifungal agents KW - blastomycosis KW - drug therapy KW - fluconazole KW - human diseases KW - infections KW - ketoconazole KW - miconazole KW - reviews KW - therapy KW - Blastomyces dermatitidis KW - man KW - Blastomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - 2-hydroxystilbamidine KW - Bay R 3783 KW - chemotherapy KW - D0870 KW - fungistats KW - fungus KW - ICI 195,739 KW - SCH 39304 KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203047&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease. AU - Pavan, W. J. AU - Liddell, R. A. AU - Wright, A. AU - Thibaudeau, G. AU - Matteson, P. G. AU - McHugh, K. M. AU - Siracusa, L. D. JO - Mammalian Genome JF - Mammalian Genome Y1 - 1995/// VL - 6 IS - 1 SP - 1 EP - 7 SN - 0938-8990 AD - Pavan, W. J.: Laboratory for Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950102880. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Agricultural Biotechnology N2 - Mice homozygous for the lethal spotting (ls) mutation exhibit aganglionic megacolon and a white spotted coat owing to a lack of neural crest-derived enteric ganglia and melanocytes. The ls mutation disrupts the migration, differentiation or survival of these neural crest lineages during mammalian development. A human congenital disorder, Hirschsprung disease (HSCR), is also characterized by aganglionic megacolon of the distal bowel and can be accompanied by hypopigmentation of the skin. HSCR has been attributed to multiple loci acting independently or in combination. The ls mouse serves as one animal model for HSCR, and the ls gene may represent 1 of the loci responsible for some cases of HSCR in humans. This study uses 753 N2 progeny from a combination of 3 intersubspecific backcrosses to define the molecular genetic link map of the ls region and to provide resources necessary for positional cloning. Similar to some cases of HSCR, the ls mutation acts semidominantly, its phenotypic effects dependent upon the presence of modifier genes segregating in the crosses. The ls mutation was localized to a 0.8-cM region between the D2Mit113 and D2Mit174 loci. Three genes, endothelin-3 (Edn3), G-protein α-stimulating polypeptide 1 (Gnas), and phosphoenolpyruvate carboxykinase (Pck1) were assessed as candidates for the ls mutation. Only Edn3 and Gnas did not recombine with the ls mutation. It is concluded that mutational analysis of the Edn3 and Gnas genes will determine whether either gene is responsible for the neural crest deficiencies observed in ls/ls mice. KW - biotechnology KW - colon KW - gene mapping KW - linkage KW - mutations KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Hirschprung disease KW - lethal spotting KW - neural crest KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102880&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Review: pain associated with HIV infection. AU - Hirschfeld, S. AU - Morris, B. K. JO - Pediatric AIDS and HIV Infection JF - Pediatric AIDS and HIV Infection Y1 - 1995/// VL - 6 IS - 2 SP - 63 EP - 74 SN - 1045-5418 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962002103. Publication Type: Journal Article. Language: English. Number of References: 176 ref. KW - acquired immune deficiency syndrome KW - children KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - pain KW - reviews KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002103&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The third wave: HIV infection among heterosexuals in the United States and Europe. AU - Haverkos, H. W. AU - Quinn, T. C. JO - International Journal of STD & AIDS JF - International Journal of STD & AIDS Y1 - 1995/// VL - 6 IS - 4 SP - 227 EP - 232 SN - 0956-4624 AD - Haverkos, H. W.: National Institute on Drug Abuse, Rockville, Maryland, USA. N1 - Accession Number: 19952007588. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Public Health N2 - An editorial review. KW - acquired immune deficiency syndrome KW - disease transmission KW - epidemiology KW - heterosexual transmission KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infections KW - injecting drug users KW - prevention KW - risk factors KW - sexual transmission KW - surveillance KW - Europe KW - North America KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - United States of America KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007588&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Brominated chamigrane sesquiterpenes produce a novel profile of differential cytotoxicity in the NCI in vitro screen. AU - Rashid, M. A. AU - Gustafson, K. R. AU - Cardellina, J. H., II JO - Natural Product Letters JF - Natural Product Letters Y1 - 1995/// VL - 6 IS - 4 SP - 255 EP - 259 AD - Rashid, M. A.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19960310710. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Horticultural Science N2 - Bioassay-guided fractionation of an extract from the marine alga Laurencia majuscula provided 3 brominated chamigrane sesquiterpenes. These compounds produced a novel pattern of antitumour activity against the National Cancer Institute's in vitro cell line panel. They were cytotoxic to certain cell lines in the colon cancer subpanel at concentrations 10- to 100-fold lower than the mean cytotoxic concentration observed in the other tumour subpanels. KW - cell lines KW - cytotoxicity KW - in vitro KW - medicinal plants KW - medicinal properties KW - neoplasms KW - organobromine compounds KW - plant composition KW - screening KW - sesquiterpenes KW - algae KW - Ceramiales KW - Rhodomelaceae KW - plants KW - aquatic plants KW - aquatic organisms KW - eukaryotes KW - Rhodophyta KW - algae KW - seaweeds KW - Ceramiales KW - cancers KW - chemical constituents of plants KW - drug plants KW - Laurencia KW - Laurencia majuscula KW - medicinal herbs KW - officinal plants KW - screening tests KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine regulation of granuloma formation in schistosomiasis. AU - Wynn, T. A. AU - Cheever, A. W. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1995/// VL - 7 IS - 4 SP - 505 EP - 511 SN - 0952-7915 AD - Wynn, T. A.: National Institutes of Health, Building 4/126, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800793. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Registry Number: 308079-78-9. Subject Subsets: Helminthology N2 - This review focuses primarily on recent advances concerning the role of Th1 and Th2 cytokines in granuloma formation in schistosomiasis under the headings: Th2 cytokines induce granulomatous inflammation; Th1-associated cytokines suppress granuloma formation; adhesion molecules, chemokines and TNF-α; cytokines and downmodulation. KW - cytokines KW - granuloma KW - helminths KW - immunopathology KW - inflammation KW - parasites KW - reviews KW - t lymphocytes KW - tumour necrosis factor KW - Schistosoma mansoni KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - downregulation KW - granulomas KW - immunopathogenesis KW - parasitic worms KW - Strigeida KW - T cells KW - T helper cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800793&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fluconazole versus itraconazole in therapy of oropharyngeal candidiasis in cancer patients: a prospective comparative randomized trial. AU - Studená, V. AU - Sycová, Z. AU - Helpianska, L. AU - Sorkovská, D. AU - Pichna, P. AU - Lacka, J. AU - Hlavacova, E. AU - Oravcová, E. AU - Krčméry, V., Jr. AU - Studená, M. AU - Kukucková, E. JO - Journal of Chemotherapy JF - Journal of Chemotherapy Y1 - 1995/// VL - 7 IS - Suppl. 4 SP - 204 EP - 205 SN - 1120-009X AD - Studená, V.: National Cancer Institute, 83301 Bratislava, Slovakia. N1 - Accession Number: 19961201898. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref. Registry Number: 86386-73-4, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - A prospective, randomized trial was conducted to compare the efficacy and toxicity of fluconazole (100 mg/d for 10 d) and itraconazole (100 mg/d for 15 d) in the treatment of 53 cancer patients from Bratislava, Slovakia, with oropharyngeal candidosis. Infections were due to Candida albicans (39 cases), C. tropicalis (3), Torulopsis glabrata (3), and C. krusei and C. albicans (8). Fluconazole showed a better efficacy and mycological eradication rate (94.7%) than itraconazole (86%; P<0.01). The relapse rate in the itraconazole group was 53.8% compared with 21% in the fluconazole-treated group. KW - antifungal agents KW - candidosis KW - clinical trials KW - drug therapy KW - efficacy KW - fluconazole KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - itraconazole KW - mouth KW - neoplasms KW - opportunistic infections KW - pharynx KW - predisposition KW - therapy KW - Slovakia KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida tropicalis KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - Pezizomycotina KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Advances in antimicrobial chemotherapy KW - cancers KW - Candida krusei KW - candidiasis KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - therapeutics KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201898&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nucleic acid vaccines. AU - Vogel, F. R. AU - Sarver, N. JO - Clinical Microbiology Reviews JF - Clinical Microbiology Reviews Y1 - 1995/// VL - 8 IS - 3 SP - 406 EP - 410 SN - 0893-8512 AD - Vogel, F. R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010038. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health N2 - The author reviews the development of nucleic acid vaccines. KW - immunization KW - nucleic acids KW - reviews KW - vaccine development KW - vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010038&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosomiasis. AU - James, S. AU - Colley, D. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1995/// VL - 8 IS - 5 SP - 351 EP - 355 SN - 0951-7375 AD - James, S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960801271. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Schistosomiasis is reviewed with reference to epidemiology and clinical disease, diagnosis, chemotherapy, vaccine development, experimental pathogenesis and human immunology. Research on biochemical and immunological resistance mechanisms to infection, disease development and drug action should contribute to the design of more efficacious integrated control strategies. KW - clinical aspects KW - control KW - diagnosis KW - drug therapy KW - epidemiology KW - helminths KW - human diseases KW - immunology KW - parasites KW - pathogenesis KW - resistance KW - reviews KW - schistosomiasis KW - vaccines KW - man KW - Schistosoma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - chemotherapy KW - clinical picture KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Does zidovudine cause non-Hodgkin's lymphoma? AU - Coté, T. R. AU - Biggar, R. J. T2 - AIDS JO - AIDS JF - AIDS Y1 - 1995/// VL - 9 IS - 4 SP - 404 EP - 405 SN - 0269-9370 AD - Coté, T. R.: The AIDS/Cancer Study Group, Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Blvd, Rockville, MD 20852, USA. N1 - Accession Number: 19952006585. Publication Type: Correspondence. Language: English. Number of References: 6 ref. Registry Number: 30516-87-1. KW - acquired immune deficiency syndrome KW - aetiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - non-Hodgkin's lymphoma KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - causal agents KW - etiology KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006585&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-10 synergizes with multiple cytokines in enhancing HIV production in cells of monocytic lineage. AU - Weissman, D. AU - Poli, G. AU - Fauci, A. S. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1995/// VL - 9 IS - 5 SP - 442 EP - 449 AD - Weissman, D.: Laboratory of Immunoregulation, National Institutes of Health, Building 10, Room 6A02, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010478. Publication Type: Journal Article. Language: English. Number of References: 42 ref. KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - interleukins KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation between stage of disease and neurobehavioral measures in children with symptomatic HIV disease. AU - Brouwers, P. AU - Tudor-Williams, G. AU - DeCarli, C. AU - Moss, H. A. AU - Wolters, P. L. AU - Civitello, L. A. AU - Pizzo, P. A. JO - AIDS JF - AIDS Y1 - 1995/// VL - 9 IS - 7 SP - 713 EP - 720 SN - 0269-9370 AD - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Center, Rm 13N240, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19952007548. Publication Type: Journal Article. Language: English. Number of References: 37 ref. KW - acquired immune deficiency syndrome KW - CD4 antigens KW - central nervous system KW - clinical aspects KW - core protein p24 KW - diseases KW - encephalopathy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - markers KW - neurology KW - paediatrics KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4 KW - clinical picture KW - CNS KW - cognitive dyfunction KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - p24 KW - p24 antigen KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007548&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neutralization of primary HIV-1 isolates by anti-envelope monoclonal antibodies. AU - D'Souza, M. P. AU - Milman, G. AU - Bradac, J. A. AU - McPhee, D. AU - Hanson, C. V. AU - Hendry, R. M. JO - AIDS JF - AIDS Y1 - 1995/// VL - 9 IS - 8 SP - 867 EP - 874 SN - 0269-9370 AD - D'Souza, M. P.: Pathogenesis and Basis Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Solar Building, Room 2C35, Bethesda MD 20892, USA. N1 - Accession Number: 19952009247. Publication Type: Journal Article. Language: English. Number of References: 46 ref. KW - envelope proteins KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - laboratory methods KW - monoclonal antibodies KW - neutralization KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - laboratory techniques KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009247&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV infection and AIDS risk behaviors among injecting drug users entering methadone treatment: an update. AU - Battjes, R. J. AU - Pickens, R. W. AU - Brown, L. S. Jr JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1995/// VL - 10 IS - 1 SP - 90 EP - 96 AD - Battjes, R. J.: National Institute on Drug Abuse, 5600 Fishers Lane, Room 10A-38, Rockville, MD 20857, USA. N1 - Accession Number: 19962001102. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 1095-90-5, 76-99-3. KW - acquired immune deficiency syndrome KW - behaviour KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - injecting drug users KW - methadone KW - prevention KW - risk behaviour KW - sexual behaviour KW - sociology KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - behavior KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - risk behavior KW - sexual behavior KW - sexual practices KW - sexuality KW - social aspects KW - treatment centers KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001102&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation between human T-lymphotropic virus type I and neurologic diseases in Panama: 1985-1990. AU - Gracia, F. AU - Castillo, L. C. AU - Larreategui, M. AU - Roberts, B. AU - Cedeño, V. AU - Heneine, W. AU - Blattner, W. AU - Kaplan, J. E. AU - Levine, P. H. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1995/// VL - 10 IS - 2 SP - 192 EP - 197 AD - Gracia, F.: Correspondence address: P.H. Levine, Viral Epidemiology Branch, Executive Plaza North 434, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001117. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Tropical Diseases N2 - Human T-cell lymphotropic virus type I (HTLV-I) is endemic in the Caribbean basin and in Japan. HTLV-II, a closely related virus, is endemic in several groups of native Americans, including Panamanian Guaymi. In Panama, a nationwide HTLV-I/II seroprevalence of 102% has been reported. The authors evaluated the frequency of HTLV-I/II infection in patients with neurological diseases admitted to state tertiary hospitals in Panama City between 1985 and 1990. Nineteen of 322 patients with eligible diagnoses had antibodies to HTLV-I/II, 17 with HTLV-I and 2 with HTLV-II. HTLV-I was associated with spastic paraparesis (13 of 23, 56.5% vs. 4 of 299, 1.3%, P <0.001) and with cerebellar syndrome (2 of 13, 15.4%) and multiple sclerosis (2 of 54, 3.7%) (P <0.05 for both diseases compared with subject with none of these diagnoses). The two HTLV-I infected patients with cerebellar syndrome later developed spastic paraparesis. HTLV-II infection was noted in one patient with cerebellar syndrome and one with amyotrophic lateral sclerosis. All patients with other diagnoses were seronegative. Among patients with spastic paraparesis, HTLV-I-infected patients were clinically indistinguishable from seronegative subjects. There is apparently an overlapping clinical spectrum of neurologic diseases associated with HTLV-I and HTLV-II infection. KW - brain KW - epidemiology KW - HTLV-I infections KW - human diseases KW - infections KW - nervous system KW - nervous system diseases KW - neurology KW - sclerosis KW - tropical spastic paraparesis KW - Central America KW - Panama KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human t-cell lymphotropic virus type ii KW - man KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - Central America KW - Developing Countries KW - Latin America KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - cerebrum KW - HTLV-BLV group KW - neuropathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence specificity in the higher-order interaction of the Rev protein of HIV-1 with its target sequence, the RRE. AU - Powell, D. M. AU - Zhang, M. J. AU - Konings, D. A. M. AU - Wingfield, P. T. AU - Stahl, S. J. AU - Dayton, E. T. AU - Dayton, A. J. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1995/// VL - 10 IS - 3 SP - 317 EP - 323 AD - Powell, D. M.: Correspondence address: A.I. Dayton, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001123. Publication Type: Journal Article. Language: English. Number of References: 39 ref. KW - binding KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - mutations KW - Rev protein KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Rev response elements KW - wild type KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: the phenanthroline-cuprous complex. AU - Mazumder, A. AU - Gupta, M. AU - Perrin, D. M. AU - Sigman, D. S. AU - Rabinovitz, M. AU - Pommier, Y. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 1 SP - 115 EP - 125 SN - 0889-2229 AD - Mazumder, A.: Laboratory of Molecular Pharmacology, Bldg. 37, Rm. 5C25, Division of Cancer Treatment, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952005041. Publication Type: Journal Article. Language: English. Number of References: 31 ref. KW - antiviral agents KW - human diseases KW - inhibition KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - integrase KW - phenanthroline-cuprous complex KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005041&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chitinase as a vaccine. AU - Shahabuddin, M. JO - Parasitology Today JF - Parasitology Today Y1 - 1995/// VL - 11 IS - 2 SP - 46 EP - 47 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805918. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 9001-06-3. Subject Subsets: Helminthology; Protozoology N2 - The suggestion that chitinase could be a potential generalized target for blocking the transmission of various parasites is discussed with reference to recent studies on Brugia malayi and Wuchereria bancrofti. The presence of chitinase in Plasmodium, Leishmania and Trypanosoma is also discussed. KW - chitinase KW - helminths KW - human diseases KW - parasites KW - vaccines KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805918&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Humoral and cellular immune responses in rhesus macaques infected with human immunodeficiency virus type 2. AU - Abimiku, A. G. AU - Franchini, G. AU - Aldrich, K. AU - Myagkikh, M. AU - Markham, P. AU - Gard, E. AU - Gallo, R. C. AU - Robert-Guroff, M. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 3 SP - 383 EP - 393 SN - 0889-2229 AD - Abimiku, A. G.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007424. Publication Type: Journal Article. Language: English. Number of References: 65 ref. KW - animal models KW - cytotoxic T lymphocytes KW - HIV-2 infections KW - human diseases KW - immune response KW - Human immunodeficiency virus 2 KW - Macaca KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - human immunodeficiency virus type 2 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007424&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The cytoplasmic ribosomal RNAs of Plasmodium spp. AU - McCutchan, T. F. AU - Li, J. AU - McConkey, G. A. AU - Rogers, M. J. AU - Waters, A. P. JO - Parasitology Today JF - Parasitology Today Y1 - 1995/// VL - 11 IS - 4 SP - 134 EP - 138 AD - McCutchan, T. F.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950807486. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology N2 - Understanding of Plasmodium spp. cytoplasmic ribosomal RNA genes whose expression is developmentally regulated is reviewed under the headings: genomic organization of rDNA units; individual genes, rRNAs and transcriptional control; ramifications of rRNA analysis. KW - development KW - gene expression KW - genes KW - molecular genetics KW - parasites KW - ribosomal RNA KW - Plasmodium KW - protozoa KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807486&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Herbal pharmacotherapy for the attenuation of electroconvulsive shock-induced anterograde and retrograde amnestic deficits. AU - Faruqi, S. AU - Chittaranjan Andrade AU - Ramteke, S. AU - Joseph, J. AU - Venkataraman, B. V. AU - Naga Rani, M. A. JO - Convulsive Therapy JF - Convulsive Therapy Y1 - 1995/// VL - 11 IS - 4 SP - 241 EP - 247 AD - Faruqi, S.: Department of Pharmacology, St. John's Medical College, National Institute of Mental Health and Neurosciences, Bangalore, India. N1 - Accession Number: 19960309810. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Horticultural Science N2 - BR-16A is an herbal medication used in India to enhance cognition. Sixty adult male Sprague Dawley rats received either BR-16A (200 mg/kg) or vehicle alone for 16 days. During the first 7 days, rats were trained in a spatial memory task using the Hebb Williams complex maze. Once a day for the next 2 days, rats received either true or sham electroconvulsive shock (ECS) treatments. During the last 7 days of the study, rats were reexposed to the maze to assess recall of pre-ECS training and to evaluate further improvement in learning scores. BR-16A-treated rats performed better than controls both before and after ECS. It is concluded that BR-16A facilitates learning and that this effect extends to a protection against ECS-induced anterograde and retrograde amnesia. BR-16A may hence hold promise in the restriction of ECT-induced cognitive compromise. An unexpected observation in this study was that BR-16A attenuated seizure duration; implications and mechanisms are discussed. KW - anticonvulsant properties KW - herbal drugs KW - learning KW - medicinal plants KW - nervous system KW - pharmacology KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anti-convulsant properties KW - anti-epileptic properties KW - BR-16A KW - drug plants KW - herbal medicines KW - medicinal herbs KW - officinal plants KW - Plant Science (General) (FF000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960309810&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Syncytium formation in cultured human lymphoid tissue: fusion of implanted HIV glycoprotein 120/41-expressing cells with native CD4+ cells. AU - Margolis, L. B. AU - Glushakova, S. AU - Baibakov, B. AU - Zimmerberg, J. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 6 SP - 697 EP - 704 SN - 0889-2229 AD - Margolis, L. B.: Correspondence address: J. Zimmerberg, Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Building 10, Room 10014, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008195. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - cellular biology KW - formation KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - pathogenesis KW - syncytia KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cell biology KW - fusion KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008195&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antisense phosphorothioate oligodeoxynucleotides alter HIV type 1 replication in cultured human macrophages and peripheral blood mononuclear cells. AU - Weichold, F. F. AU - Lisziewicz, J. AU - Zeman, R. A. AU - Nerurkar, L. S. AU - Agrawal, S. AU - Reitz, M. S. Jr. AU - Gallo, R. C. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 7 SP - 863 EP - 867 SN - 0889-2229 AD - Weichold, F. F.: Hematology Branch, Building 10, Room 7C103, NHLBI, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-1652, USA. N1 - Accession Number: 19952010935. Publication Type: Journal Article. Language: English. Number of References: 33 ref. KW - antiviral agents KW - cell culture KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - macrophages KW - replication KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - oligodeoxynucleotides KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Highly attentuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques. AU - Franchini, G. AU - Robert-Guroff, M. AU - Tartaglia, J. AU - Aggarwal, A. AU - Abimiku, A. AU - Benson, J. AU - Markham, P. AU - Limbach, K. AU - Hurteau, G. AU - Fullen, J. AU - Aldrich, K. AU - Miller, N. AU - Sadoff, J. AU - Paoletti, E. AU - Gallo, R. C. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 8 SP - 909 EP - 920 SN - 0889-2229 AD - Franchini, G.: Laboratory of Tumor Cell Biology, Building 37, Room 6A11, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952010434. Publication Type: Journal Article. Language: English. Number of References: 53 ref. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - immunization KW - immunology KW - recombinant vaccines KW - vectors KW - Human immunodeficiency virus 2 KW - Macaca KW - man KW - poxviridae KW - Salmonella typhimurium KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - dsDNA viruses KW - DNA viruses KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - AIDS KW - bacterium KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 2 KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010434&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain. AU - Ott, D. E. AU - Coren, L. V. AU - Johnson, D. G. AU - Sowder, R. C. II AU - Arthur, L. O. AU - Henderson, L. E. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 9 SP - 1003 EP - 1006 SN - 0889-2229 AD - Ott, D. E.: AIDS Vaccine Program, Program Resources Incorporated/Dyn Corp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19952011091. Publication Type: Journal Article. Language: English. Number of References: 24 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infectivity KW - pathogenesis KW - proteins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cyclophilin A KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - virions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952011091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Conference on Advances in AIDS Vaccine Development: Seventh Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, November 6-10, 1994. AU - Lawrence, D. N. AU - Schultz, A. M. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 10 SP - 1277 EP - 1319 SN - 0889-2229 AD - Lawrence, D. N.: Vaccine and Prevention Research Program, Division of AIDS, NIAID, National Institutes of Health, Solar Building, Room 2A28A, 6003 Executive Boulevard, Rockville, MD 20892-7620, USA. N1 - Accession Number: 19962001150. Publication Type: Journal Article; Conference paper; Journal article. Language: English. KW - acquired immune deficiency syndrome KW - BCG vaccine KW - cytotoxic T lymphocytes KW - design KW - HIV infections KW - human immunodeficiency viruses KW - peptides KW - vaccines KW - viral diseases KW - Listeria monocytogenes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Listeria KW - Listeriaceae KW - Bacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - AIDS KW - bacterium KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001150&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HLA Class II on HIV particles is functional in superantigen presentation to human T cells: implications for HIV pathogenesis. AU - Rossio, J. L. AU - Bess, J. Jr AU - Henderson, L. E. AU - Cresswell, P. AU - Arthur, L. O. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1995/// VL - 11 IS - 12 SP - 1433 EP - 1439 SN - 0889-2229 AD - Rossio, J. L.: AIDS Vaccine Program, Program Resources, Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19962002019. Publication Type: Journal Article. Language: English. Number of References: 43 ref. KW - antigens KW - cell mediated immunity KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - major histocompatibility complex KW - pathogenesis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenicity KW - cellular immunity KW - histocompatibility complex KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunogens KW - immunological reactions KW - superantigens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV). AU - Crowe, J. E., Jr. JO - Vaccine JF - Vaccine Y1 - 1995/// VL - 13 IS - 4 SP - 415 EP - 421 SN - 0264-410X AD - Crowe, J. E., Jr.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962000817. Publication Type: Journal Article; Conference paper; Journal article. Corporate Author: WHO Programme for Vaccine Development. Language: English. N2 - A report of a meeting held in Nyon, Switzerland on 27 March 1994 by the WHO Programme for Vaccine Development. KW - human diseases KW - immunization KW - parainfluenza KW - parainfluenza viruses KW - vaccine development KW - vaccines KW - human respiratory syncytial virus KW - man KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Paramyxovirinae KW - immune sensitization KW - parainfluenza virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000817&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunoreactive antigenic sites of Cysticercus cellulosae relevant to human neurocysticercosis - immunocytochemical localization using human CSF as source of antibody. AU - Shankar, S. K. AU - Ravi, V. AU - Suryanarayana, V. AU - Chandramukhi, A. AU - Ravikumar, B. V. JO - Clinical Neuropathology JF - Clinical Neuropathology Y1 - 1995/// VL - 14 IS - 1 SP - 33 EP - 36 SN - 0722-5091 AD - Shankar, S. K.: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. N1 - Accession Number: 19960800475. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Helminthology N2 - In order to identify the relevant antigens of Cysticercus cellulosae [Taenia solium] recognized within the human central nervous system, immunocytochemical localization of antigens on the larva was carried out using cerebrospinal fluid of patients as the source of primary antibody. CSF from 9 proven cases of neurocysticercosis, 2 cases of culture-proven tuberculous meningitis, and 2 cases of spinal disc prolapse with no other infective or neurological disorders, were used in this study. The CSF from all the cases of neurocysticercosis reacted intensely with the glycocalyx over the integument of the cyst bladder wall. The other structures recognised by the CSF antibodies were the cytoplasm of the tegumentary cytons, stroma and the ductular system of the bladder wall. The cells, stroma and calcareous corpuscles of the scolex reacted to varying degrees with the CSF. The tegument of the spiral canal and sucker muscles in the scolex were not immunoreactive. These results suggest that the glycocalyx is the most antigenic anatomical structure of the C. cellulosae and that patients develop antibodies to it. KW - antibodies KW - antigens KW - developmental stages KW - helminths KW - human diseases KW - immunocytochemistry KW - metacestodes KW - neurocysticercosis KW - parasites KW - Taenia solium KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - growth phase KW - immunogens KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful treatment of catheter-associated fungemia due to Candida krusei and Trichosporon beigelii in a leukemic patient receiving prophylactic itraconazole. AU - Špánik, S. AU - Kollár, T. AU - Gyarfáš, J. AU - Kunová, A. AU - Krčméry, V. JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1995/// VL - 14 IS - 2 SP - 148 EP - 149 SN - 0934-9723 AD - Špánik, S.: Department of Clinical Medicine, National Cancer Institute and University of Trnava, 833 03 Bratislava, Slovakia. N1 - Accession Number: 19951202400. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 1397-89-3, 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - A case of catheter-associated fungaemia due to C. krusei and T. beigelii is reported in a 19-yr-old man from Slovakia with acute myelogenous leukaemia. The patient was receiving prophylactic itraconazole. Intravenous amphotericin B (50 mg/kg daily) was administered and the central venous catheter was removed. Because the patient refused further hospitalization, he was discharged on oral fluconazole (400 mg/d) for 14 d. Chest X-ray, ophthalmological examination and ultrasound examination 35 d after resolution of the fungaemia failed to reveal any late consequences such as organ involvement. KW - amphotericin B KW - antifungal agents KW - blood KW - candidosis KW - case reports KW - catheters KW - drug therapy KW - fluconazole KW - fungaemia KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - leukaemia KW - opportunistic infections KW - predisposition KW - therapy KW - Slovakia KW - Candida acidothermophilum KW - man KW - Trichosporon beigelii KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - blood cancer KW - Candida krusei KW - candidiasis KW - chemotherapy KW - fungemia KW - fungistats KW - fungus KW - Hyphomycetes KW - leucaemia KW - leukemia KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202400&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful treatment of catheter-related fusarial infection in immunocompromised children. AU - Velasco, E. AU - Martins, C. A. AU - Nucci, M. JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1995/// VL - 14 IS - 8 SP - 697 EP - 699 SN - 0934-9723 AD - Velasco, E.: Infectious Disease Department, Hospital do Cancer, National Cancer Institute, Rio de Janeiro, RJ, Brazil. N1 - Accession Number: 19951202924. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - Cases are reported in 4 children (aged 3-12 yr) from Brazil with acute leukaemia or solid tumours, who developed catheter-related fusarial infection. Blood cultures drawn through the central venous catheter grew Fusarium spp. in all cases. All patients recovered after removal of the central venous catheter and treatment with amphotericin B. KW - amphotericin B KW - antifungal agents KW - blood KW - case reports KW - catheters KW - children KW - drug therapy KW - fungaemia KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - leukaemia KW - neoplasms KW - opportunistic infections KW - predisposition KW - therapy KW - Brazil KW - Fusarium KW - man KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - blood cancer KW - cancers KW - chemotherapy KW - fungemia KW - fungistats KW - fungus KW - Hyphomycetes KW - leucaemia KW - leukemia KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202924&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Report of catheter-associated Trichosporon pullulans break-through fungemia in a cancer patient. AU - Kunová, A. AU - Sorkovská, D. AU - Sufliarsky, J. AU - Helpianska, L. AU - Krčméry, V. T2 - European Journal of Clinical Microbiology & Infectious Diseases JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1995/// VL - 14 IS - 8 SP - 729 EP - 730 SN - 0934-9723 AD - Kunová, A.: Department of Medicine, National Cancer Institute, Medical School and University of Trnava, 833 10 Bratislava, Slovakia. N1 - Accession Number: 19951202926. Publication Type: Correspondence. Language: English. Number of References: 3 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 65-yr-old woman from Slovakia with ovarian cancer who developed fever after chemotherapy despite receiving prophylactic ketoconazole. Blood cultures grew T. pullulans, which was also cultured from the tip of a central venous catheter. The catheter was removed and intravenous amphotericin B was administered (0.5 mg/kg daily) but the patient's condition deteriorated and she died. KW - blood KW - case reports KW - catheters KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - mycoses KW - neoplasms KW - opportunistic infections KW - predisposition KW - Slovakia KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - cancers KW - fungus KW - Hyphomycetes KW - Trichosporon pullulans KW - trichosporonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202926&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Developmentally regulated expression of a Giardia lamblia cyst wall protein gene. AU - Mowatt, M. R. AU - Luján, H. D. AU - Cotten, D. B. AU - Bowers, B. AU - Yee, J. AU - Nash, T. E. AU - Stibbs, H. H. JO - Molecular Microbiology JF - Molecular Microbiology Y1 - 1995/// VL - 15 IS - 5 SP - 955 EP - 963 SN - 0950-382X AD - Mowatt, M. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19960802780. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Protozoology N2 - The expression of a gene of Giardia lamblia [Giardia duodenalis] that encodes a protein component of the cyst wall was investigated. Transcripts from the cyst wall protein gene increased more than 100-fold during encystation, reaching a maximum between 5 and 24 h after induction. Cyst wall protein expression also increased dramatically during encystation, and, prior to its incorporation into the nascent cyst wall, the protein is contained within the encystation-specific vesicles of encysting trophozoites. The sequence of the cloned gene predicts an acidic, leucine-rich polypeptide of MW 26 000 that contains 5.3 tandemly arranged copies of a degenerate 24-amino-acid repeat. A hydrophobic amino-terminal peptide probably serves as the initial signal that targets this protein to a secretory pathway involving vesicular localization during encystation and, ultimately, secretion to form the cyst wall. KW - amino acid sequences KW - developmental stages KW - gene expression KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - transcription KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cyst wall protein KW - DNA sequences KW - DNA transcription KW - growth phase KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802780&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The human immunodeficiency virus type 1 Rev protein and the Rev-responsive element counteract the effect of an inhibitory 5′ splice site in a 3′ untranslated region. AU - Barksdale, S. K. AU - Baker, C. C. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1995/// VL - 15 IS - 6 SP - 2962 EP - 2971 SN - 0270-7306 AD - Barksdale, S. K.: Laboratory of Tumor Virus Viology, National Cancer Institute, Bethesda, MD 20892-5055, USA. N1 - Accession Number: 19962002081. Publication Type: Journal Article. Language: English. Number of References: 63 ref. KW - gene expression KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - Rev protein KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Rev responsive element KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002081&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum protein, lipid and selected vitamins during caloric restriction and soyabean supplementation in the diet of normal and tumour bearing mice. AU - Purna Mukhopadhyay AU - Jamuna Bhattacharyya AU - Utpal Sanyal AU - Sukta Das JO - Nutrition Research JF - Nutrition Research Y1 - 1995/// VL - 15 IS - 7 SP - 983 EP - 992 SN - 0271-5317 AD - Purna Mukhopadhyay: Department of Experimental Leukaemia, Chittaranjan National Cancer Institute, Calcutta - 700 026, India. N1 - Accession Number: 19951413642. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition N2 - The effects of a soyabean diet during 40% energy restriction on serum protein, lipids and vitamin status of the host were evaluated in Moloney virus-induced leukaemia (MVL) and Dalton's ascitic lymphoma (DL) bearing mice and compared with normal controls. The levels of serum vitamins A and E which declined in the presence of tumours could be improved following soyabean supplementation. Increased serum albumin noted during energy restriction could be brought down to the normal level using the soya diet. Significant hypercholesterolaemic effects of the soyabean diet were noted in all cases. The study indicates that alterations of protein, lipid and vitamins in the serum of a tumour bearing host could be modified by specific diets along with better control of the disease. KW - blood KW - blood lipids KW - blood proteins KW - energy deprivation KW - neoplasms KW - retinol KW - soyabeans KW - supplements KW - vitamin E KW - vitamins KW - Glycine (Fabaceae) KW - mice KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - axerophthol KW - blood plasma proteins KW - blood serum proteins KW - cancers KW - soybeans KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413642&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association of postprandial triglyceride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities (ARIC) Study. AU - Sharrett, A. R. AU - Chambless, L. E. AU - Heiss, G. AU - Paton, C. C. AU - Patsch, W. JO - Arteriosclerosis, Thrombosis, and Vascular Biology JF - Arteriosclerosis, Thrombosis, and Vascular Biology Y1 - 1995/// VL - 15 IS - 12 SP - 2122 EP - 2129 AD - Sharrett, A. R.: Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockledge Bldg Room 8164, Bethesda, MD 20892-7934, USA. N1 - Accession Number: 19961406911. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 79-81-2. Subject Subsets: Human Nutrition N2 - Blood lipid alterations after a fatty meal may be atherogenic, but there is little information regarding their associations with disease independent of fasting lipids. Asymptomatic atherosclerosis cases (n=229) and 373 control subjects free of atherosclerosis, as defined by carotid intima-media thickness on ultrasound images, were given a fatty meal with vitamin A, followed by 3.5- and 8-h measurements of triglycerides (TGs), TG-rich lipoprotein TGs, apoprotein B48 and retinyl palmitate. Among white men and women but not among blacks, case status was associated with greater postprandial responses of TGs and TG-rich lipoprotein TGs, but only in nonobese persons (body mass index <30 kg/m²). The associations were strong and significant after controlling for coronary risk factors (odds ratio, ~2.0) and fasting TGs (odds ratio, 1.5). Associations with other postprandial lipid measurements did not persist after controlling for fasting lipids. Elevated postprandial TGs appear to be an independent risk factor for carotid intimal thickening in nonobese whites. The lack of such a relation in obese subjects and the lipid profile they manifest suggest that postprandial TGs must be accompanied by accumulation of TG-rich lipoprotein remnants to be atherogenic. KW - atherosclerosis KW - blood lipids KW - fats KW - intake KW - lipoproteins KW - retinyl palmitate KW - triacylglycerols KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - retinol palmitate KW - triglycerides KW - vitamin A palmitate KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406911&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human herpesvirus 6 in AIDS. AU - Lusso, P. AU - Gallo, R. C. JO - Immunology Today JF - Immunology Today Y1 - 1995/// VL - 16 IS - 2 SP - 67 EP - 71 SN - 0167-4919 AD - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MA 20892, USA. N1 - Accession Number: 19962002096. Publication Type: Journal Article. Language: English. Number of References: 41 ref. KW - acquired immune deficiency syndrome KW - aetiology KW - CD4+ lymphocytes KW - disease course KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune system KW - natural killer cells KW - herpesviridae KW - human herpesvirus 6 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Roseolovirus KW - Betaherpesvirinae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - causal agents KW - CD4+ cells KW - disease progression KW - etiology KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002096&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nonspecific and lymphocytic interstitial pneumonitis in HIV-infected individuals. AU - Ognibene, F. P. JO - Seminars in Respiratory and Critical Care Medicine JF - Seminars in Respiratory and Critical Care Medicine Y1 - 1995/// VL - 16 IS - 3 SP - 227 EP - 230 AD - Ognibene, F. P.: National Institutes of Health, Critical Care Medicine Department, Building 10, Room 7D43, 10 Center Drive, MSC-1662, Bethesda, MD 20892-1662, USA. N1 - Accession Number: 19962006939. Publication Type: Journal Article. Language: English. Number of References: 31 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lungs KW - pathology KW - pneumonitis KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - general account KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - lymphocytic interstitial pneumonitis KW - non-specific interstitial pneumonitis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006939&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anti-interleukin-4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine schistosomiasis japonica. AU - Cheever, A. W. AU - Finkelman, F. D. AU - Cox, T. M. JO - Parasite Immunology JF - Parasite Immunology Y1 - 1995/// VL - 17 IS - 2 SP - 103 EP - 109 SN - 0141-9838 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803940. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 9008-11-1, 207137-56-2. Subject Subsets: Helminthology; Tropical Diseases N2 - Anti-interleukin-4 (IL-4) treatment of Schistosoma japonicum infected mice markedly inhibited in vitro secretion of the Th2 cytokines IL-4 and IL-5 from antigen stimulated spleen cells, but enhanced the secretion of the Th1 cytokine IFN-γ. IL-2 secretion was unaffected. Hepatic fibrosis was markedly diminished in anti IL-4 treated mice at 10 weeks pi while granulomas around S. japonicum eggs in the liver were slightly-to-moderately increased in size. The number of eggs/worm pair in the tissues and faeces did not differ significantly in treated and untreated mice. It is suggested that Th2 cytokine responses are important in the genesis of schistosomal hepatic fibrosis. KW - cytokines KW - experimental infections KW - fibrosis KW - helminths KW - hepatic fibrosis KW - human diseases KW - interferon KW - interleukin 4 KW - interleukin 5 KW - laboratory animals KW - liver KW - parasites KW - pathogenesis KW - schistosomiasis KW - Digenea KW - mice KW - Muridae KW - rodents KW - Schistosoma japonicum KW - Schistosomatidae KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - bilharzia KW - bilharziasis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803940&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunoregulation in human lymphatic filariasis: the role of interleukin 10. AU - Siddhartha Mahanty AU - Nutman, T. B. JO - Parasite Immunology JF - Parasite Immunology Y1 - 1995/// VL - 17 IS - 8 SP - 385 EP - 392 SN - 0141-9838 AD - Siddhartha Mahanty: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950809063. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 130068-27-8. Subject Subsets: Helminthology; Tropical Diseases N2 - In humans with lymphatic filariasis, microfilaraemia is associated with a parasite antigen-specific hyporesponsiveness when assessed by cell proliferation and secretion of interleukin-2 and interferon-γ. Hyporesponsiveness in these individuals is not only parasite antigen-specific but appears to be limited to Th1-type responses. Th2-mediated responses such as IL-5 secretion and IgE antibody production to parasite antigens are generally strong and usually no different than those seen in immunologically more reactive amicrofilaraemic individuals with chronic lymphatic pathology. The mechanisms by which Th1 responses are inhibited have not yet been elucidated, but some studies suggest that down-regulatory cytokines such as IL-10 may be involved in this process. Mononuclear cells from microfilaraemic individuals have been found to secrete greater quantities of IL-10 spontaneously and in response to parasite antigens. Mechanisms by which IL-10 may be induced by the parasite and the mode by which IL-10 may regulate parasite antigen-specific Th1 responses in these individuals are discussed. KW - cytokines KW - helminths KW - infections KW - interleukin 10 KW - interleukins KW - lymphatic filariasis KW - parasites KW - T lymphocytes KW - man KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - immunomodulation KW - immunoregulation KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - T helper cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809063&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determination of the anti-HIV drug 2′-β-fluoro-2′,3′-dideoxyadenosine in biological fluids by reversed-phase HPLC. AU - Roth, J. S. AU - Kelley, J. A. JO - Journal of Liquid Chromatography JF - Journal of Liquid Chromatography Y1 - 1995/// VL - 18 IS - 3 SP - 441 EP - 462 SN - 0148-3919 AD - Roth, J. S.: Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Building 37, Room 5C-02, Bethesda, MD 20892-0037, USA. N1 - Accession Number: 19952010173. Publication Type: Journal Article. Language: English. Number of References: 30 ref. KW - analogues KW - antiviral agents KW - biological fluids KW - detection KW - dideoxynucleosides KW - drugs KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - medicines KW - pharmaceuticals KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010173&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Racial difference in body core temperature between Pima Indian and Caucasian men. AU - Rising, R. AU - Fontvieille, A. M. AU - Larson, D. E. AU - Spraul, M. AU - Bogardus, C. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1995/// VL - 19 IS - 1 SP - 1 EP - 5 SN - 0307-0565 AD - Rising, R.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541-A, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19951404520. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition N2 - A low body temperature is associated with a low metabolic rate for a given body size and body composition. It was tested whether Pima Indians have lower body temperatures than Caucasians, a trait which might partly explain the high prevalence of obesity in this population. 25 Pima Indian (28±6 years old, 87.8±22.8 kg, 29±9% body fat) and 25 Caucasian (30±5 years old, 80.7±18.4 kg, 22±11% body fat) men had body core temperatures measured by telemetry for 24 h while in a respiratory chamber. Mean daily body core temperature was 36.93±0.12 and 36.90±0.22°C in Pima Indians and Caucasians, respectively. Since body core temperatures during sleep (SLBCT) correlated with percentage body fat, a subset of 10 Pima Indians and 10 Caucasians were pair-matched for body weight and percentage body fat. In this group, SLBCT was lower in Pima Indians than in Caucasians (36.45±0.10 vs. 36.65±0.27°C; P<0.01) and, ethnic group accounted for 20% of the variance in SLBCT (P<0.01). Surprisingly, the lower SLBCT was not associated with a low metabolic rate and therefore does not seem to play a role in the aetiology of obesity in Pima Indians. KW - body composition KW - body temperature KW - ethnic groups KW - metabolism KW - obesity KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Social Structure (UU480) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food intake and energy expenditure in obese female bingers and non-bingers. AU - Alger, S. AU - Seagle, H. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1995/// VL - 19 IS - 1 SP - 11 EP - 16 SN - 0307-0565 AD - Alger, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, National Institutes of Health, 4212 North 16th Street, Room 541-A, Arizona 85016, USA. N1 - Accession Number: 19951404522. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - Daily energy intake, dietary composition and energy expenditure were compared among obese binge eaters and obese non-bingers. 9 obese bingers (33±4 years old, 95±6 kg body weight, 39±1% body fat) and 9 obese non-bingers (47±3 years old, 93±5 kg body weight, 40±1% body fat) were admitted for 12 days to a metabolic unit. Binge eaters were defined as scoring >25 on the binge eating scale (BES). During the initial 8 days, subjects ate freely from 2 computerized vending machines offering a variety of foods and beverages. A weight maintenance diet was then provided for the next 4 days. 24 h energy expenditure (24EE) and respiratory quotient (24Q) were measured on the last day of both feeding periods in a respiratory chamber. Obese bingers showed a wider range of energy intake compared to non-bingers, but the mean daily energy intake was similar between the 2 groups (2587±454 vs. 2386±201 kcal/day) during 8 days of free intake. 24EE was not different between bingers and non-binger after 8 days of free intake (2298±147 vs. 2109±97 kcal/day, P=0.3) or 4 days of weight maintenance diet, even more so after adjustment for differences in fat-free mass, fat mass and age. Resting metabolic rate, sleeping metabolic rate, and macronutrient intake and oxidation were also similar between groups. In a controlled experimental environment, obese binge eaters exhibited a greater variability in daily energy intake than non-bingers, but showed no difference in mean daily energy intake, diet composition or metabolic rate compared to obese non-bingers. KW - appetite disorders KW - behaviour KW - body composition KW - energy exchange KW - energy intake KW - feeding behaviour KW - food intake KW - obesity KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - eating disorders KW - fatness KW - feeding behavior KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404522&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spontaneous overfeeding with a "cafeteria diet" in men: effects on 24-hour energy expenditure and substrate oxidation. AU - Larson, D. E. AU - Rising, R. AU - Ferraro, R. T. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1995/// VL - 19 IS - 5 SP - 331 EP - 337 SN - 0307-0565 AD - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N Sixteenth Street, Room 541, Phoenix, Arizona, 85016, USA. N1 - Accession Number: 19951407085. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition N2 - To investigate the relationship between obesity and ad libitum food intake (quantity and composition) and to assess the impact of ad libitum food intake on energy expenditure and macronutrient oxidation, male non-diabetic Pima Indian covering a wide range of body weight and body composition (30±8 years, 102.1±30.2 kg, 34± 9% body fat) were first fed a weight maintaining diet for at least 4 days before selecting their food for the next 5 days from 2 computerized vending machines offering a variety of familiar, palatable foods. 24-h energy expenditure (24EE) and substrate oxidation were measured in a respiratory chamber in the last day of each weight maintenance and ad libitum intake periods. Weight maintenance requirements averaged 2913±342 kcal/day. Energy intake during the ad libitum period increased to 4550±921 kcal/day (12±1% protein, 40±4% fat, 48±4% carbohydrate) i.e., a spontaneous overeating by 54±32% above the weight maintenance requirement, resulting in a 0.9±1.0 kg body weight gain. Neither the composition of the selected diet nor the degree of overeating was associated with physical characteristics, such as body weight and body consumption. When compared with baseline, spontaneous overeating on day 5 was associated with a 396±233 kcal/day increase in 24EE, a 607±503 kcal/day increase in carbohydrate oxidation, a 214±392 kcal/day decrease in lipid oxidation (P<0.01), and no change in protein oxidation. Increased carbohydrate oxidation correlated with the excess carbohydrate intake (r = 0.69, P=0.0001) accounting for 68±13% of the excess, whereas excess fat intake was not oxidized. In response to spontaneous overfeeding on a mixed "cafeteria diet", excess carbohydrate intake is oxidized, suggesting a physiological control of carbohydrate stores, whereas excess fat intake is channeled toward fat stores. None of the observed changes were related to indices of obesity. KW - effects KW - energy KW - energy exchange KW - food intake KW - men KW - nutrition physiology KW - obesity KW - overfeeding KW - oxidation KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - overnutrition KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407085&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relations of body fat and fat distribution to the serum lipid, apolipoprotein and insulin concentrations of Samoan men and women. AU - Galanis, D. J. AU - McGarvey, S. T. AU - Sobal, J. AU - Bausserman, L. AU - Levinson, P. D. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1995/// VL - 19 IS - 10 SP - 731 EP - 738 SN - 0307-0565 AD - Galanis, D. J.: Epidemiology, Demography and Biometry Program, National Institute of Aging, 7201 Wisconsin Ave., Gateway Bldg., Suite 3C-309, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951413228. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - 178 men and 147 women who were free from hypertension, diabetes and heart disease were investigated. In multivariate linear regression analyses in men body mass index (BMI) was positively associated with levels of total cholesterol, the total-HDL cholesterol ratio, apolipoprotein B and the log of triglyceride and insulin concentrations, and negatively associated with HDL and HDL2 cholesterol. The quadratic term for BMI was also found to be significantly predictive of all metabolic parameters in men, except for the log of serum insulin concentrations. Among women, in contrast, BMI levels were significantly associated only with concentrations of HDL2 cholesterol, triglyceride and insulin. In men, the associations between the abdomen-hip circumference ratio (AHR) and metabolic parameters were similar to those described for BMI, but showed no indication of non-linearity. Addition of the log of insulin to these models had little effect on the relations between the AHR and the lipid parameters, with the exceptions of total cholesterol and triglycerides. As with BMI, AHR was much less predictive of metabolic parameters in women than in men, with a significant relation existing only with the log of insulin concentrations. KW - apolipoproteins KW - blood KW - blood lipids KW - body composition KW - body fat KW - distribution KW - insulin KW - men KW - sex differences KW - women KW - American Samoa KW - Samoa KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Oceania KW - Oceania KW - Least Developed Countries KW - Developing Countries KW - Polynesia KW - Pacific Islands KW - ACP Countries KW - Commonwealth of Nations KW - Western Samoa KW - Human Nutrition (General) (VV100) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variability in metabolic rate: biological sites of regulation. AU - Tataranni, P. A. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1995/// VL - 19 IS - sup 4 SP - S102 EP - S106 SN - 0307-0565 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Rm 541, Phoenix, Arizonia 85016, USA. N1 - Accession Number: 19951413690. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition N2 - Evidence on the variability of resting metabolic rate is discussed and new lines of research into this topic are suggested. KW - metabolism KW - regulation KW - resting energy exchange KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Suppurative cutaneous granulomata caused by Microascus cinereus in a patient with chronic granulomatous disease. AU - Marques, A. R. AU - Kwon-Chung, K. J. AU - Holland, S. M. AU - Turner, M. L. AU - Gallin, J. I. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 20 IS - 1 SP - 110 EP - 114 SN - 1058-4838 AD - Marques, A. R.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseses, National Institutes of Health, Bethesda, MD 20892-1886, USA. N1 - Accession Number: 19961200400. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 9-yr-old girl from Maryland, USA, with chronic granulomatous disease who presented with erythematous papular skin lesions on the chest, back and arm. Examination of biopsy specimens from the lesions on the arm and back showed suppurative granulomata in association with acute and chronic inflammation. Histopathological examination of a specimen from the lesion on the arm revealed fungal elements and cultures yielded M. cinereus. The patient was treated with 2.5 g of intravenous amphotericin B during a 10 wk period and the lesions resolved. KW - case reports KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - mycoses KW - opportunistic infections KW - predisposition KW - Maryland KW - USA KW - man KW - Microascaceae KW - Microascus KW - Pezizomycotina KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Microascales KW - Sordariomycetes KW - Microascaceae KW - Microascus KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Ascomycotina KW - chronic granulomatous disease KW - fungus KW - Microascus cinereus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200400&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The balance of interests in natural products development. The National Cancer Institute's letter of collection. AU - Mays, T. D. AU - Duffy Mazan, K. JO - Interciencia JF - Interciencia Y1 - 1995/// VL - 20 IS - 3 SP - 130 EP - 133 SN - 0378-1844 AD - Mays, T. D.: National Cancer Institute, NIH, Building 3, Room 4A51, 900 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19970300471. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Horticultural Science N2 - The natural products programme of the National Cancer Institute (NCI) is described. The NCI letter of collection (LOC) agreement is a contractual agreement that permits the recognition of and promotes the sharing of financial rewards with indigenous peoples and source countries for their contribution to the identification and collection of natural products with potential therapeutic value in the treatment of cancer and AIDS [acquired immune deficiency syndrome]. LOC provisions, NCI obligations and source country obligations are briefly presented. KW - acquired immune deficiency syndrome KW - antineoplastic properties KW - antiviral properties KW - indigenous knowledge KW - medicinal properties KW - natural products KW - neoplasms KW - plant composition KW - AIDS KW - anti-neoplastic properties KW - anti-viral properties KW - cancers KW - chemical constituents of plants KW - Plant Science (General) (FF000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Laws and Regulations (DD500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970300471&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Management of chronic viral hepatitis in children. AU - Conjeevaram, H. S. AU - Bisceglie, A. M. di JO - Journal of Pediatric Gastroenterology and Nutrition JF - Journal of Pediatric Gastroenterology and Nutrition Y1 - 1995/// VL - 20 IS - 4 SP - 365 EP - 375 SN - 0277-2116 AD - Conjeevaram, H. S.: Liver Diseases Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952004568. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - With reference to hepatitis B, C, and D infections in children, the authors discuss the epidemiology and natural history of infections, serodiagnosis, immunotherapy and prevention stategies. KW - children KW - diagnosis KW - epidemiology KW - hepatitis B KW - hepatitis C KW - hepatitis D KW - human diseases KW - immunotherapy KW - management KW - reviews KW - viral hepatitis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fungemia in children infected with the human immunodeficiency virus: new epidemiologic patterns, emerging pathogens, and improved outcome with antifungal therapy. AU - Walsh, T. J. AU - Gonzalez, C. AU - Roilides, E. AU - Mueller, B. U. AU - Ali, N. AU - Lewis, L. L. AU - Whitcomb, T. O. AU - Marshall, D. J. AU - Pizzo, P. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 20 IS - 4 SP - 900 EP - 906 SN - 1058-4838 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Building 10, Room 13N-240, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005653. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 27 episodes of fungaemia in 22 children at the Pediatric Branch of the National Cancer Institute, Bethesda, USA, who were infected with HIV were characterized. Fungaemia in these patients presented as a community-acquired infection in the setting of out-patient total parenteral nutrition or intravenous antibiotic therapy through a chronically indwelling central venous catheter (CVC). Fungaemia developed only in patients with CVCs (P<0.001). Non-albicansCandida spp. (C. parapsilosis, C. tropicalis, C. krusei), Torulopsis glabrata, Rhodotorula rubra and Bipolaris spicifera [Cochliobolus spicifer] constituted 52% of all causes; C. albicans was the aetiological agent in the remainder. Fungaemia was detected early, within a median of 24 d after the onset of new fever, which permitted prompt administration of amphotericin B (mean dosage, 0.7 mg/kg daily; median duration, 19 d). CVCs were removed in 23 (85%) of the episodes. It is concluded that fungaemia in HIV-infected children often presents as a community-acquired infection, is frequently due to newly emerging opportunistic fungi and can be managed, with a high level of success (95% survival with no post-therapeutic sequelae), by early diagnosis, prompt initiation of amphotericin B therapy and removal of the CVC. KW - acquired immune deficiency syndrome KW - amphotericin B KW - antifungal agents KW - blood KW - catheters KW - children KW - drug therapy KW - epidemiology KW - fungaemia KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - mycoses KW - opportunistic infections KW - predisposition KW - Maryland KW - USA KW - Candida KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida parapsilosis KW - Candida tropicalis KW - cochliobolus spicifer KW - man KW - Pleosporaceae KW - Rhodotorula mucilaginosa KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Cochliobolus KW - Pleosporaceae KW - Pleosporales KW - Dothideomycetes KW - Pezizomycotina KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Rhodotorula KW - Sporidiobolales KW - Microbotryomycetes KW - Pucciniomycotina KW - Basidiomycota KW - Torulopsis KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - Candida krusei KW - chemotherapy KW - fungemia KW - fungistats KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - Rhodotorula rubra KW - Torulopsis glabrata KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005653&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytomegalovirus ureteritis as a cause of renal failure in a child infected with the human immunodeficiency virus. AU - Mueller, B. U. AU - MacKay, K. AU - Cheshire, L. B. AU - Choyke, P. L. AU - Kitchen, B. AU - Widemann, B. AU - Pizzo, P. A. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 20 IS - 4 SP - 1040 EP - 1051 SN - 1058-4838 AD - Mueller, B. U.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005656. Publication Type: Journal Article. Language: English. Number of References: 22 ref. KW - diagnosis KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inflammation KW - opportunistic infections KW - paediatrics KW - renal failure KW - ureter KW - cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - kidney failure KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005656&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiretroviral therapy: reference guide to major clinical trials in patients infected with human immunodeficiency virus. AU - Spooner, K. M. AU - Lane, H. C. AU - Masur, H. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 20 IS - 5 SP - 1145 EP - 1151 SN - 1058-4838 AD - Spooner, K. M.: Correspondence address: H. Masur, National Institutes of Health, 10 Center Drive, MSC 1662, Building 10, Room 7D43, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007852. Publication Type: Journal Article. Language: English. Number of References: 25 ref. KW - antiviral agents KW - clinical trials KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007852&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biological correlates of binge eating. AU - Yanovski, S. Z. JO - Addictive Behaviors JF - Addictive Behaviors Y1 - 1995/// VL - 20 IS - 6 SP - 705 EP - 712 SN - 0306-4603 AD - Yanovski, S. Z.: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-6600, USA. N1 - Accession Number: 19961405298. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Human Nutrition N2 - Neuroendocrine and metabolic abnormalities are seen in both anorexia nervosa and bulimia nervosa, but they have not been described in binge eating disorder, in which neither starvation nor compensatory behaviours are present. Although findings may reflect biologic differences among subgroups of binge eaters, an alternative explanation is that many of the biological correlates of binge eating are the result of metabolic derangement secondary to starvation and/or purging. The identification of binge eating disorder provides an opportunity to study the causes and concomitants of binge eating in the absence of compensatory behaviours. KW - appetite disorders KW - metabolism KW - nutrition physiology KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - eating disorders KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961405298&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Foetal nutrition and the risk of non-insulin-dependent diabetes mellitus in Pima Indians. AU - Nelson, R. G. AU - McCance, D. R. AU - Pettitt, D. J. JO - Proceedings of the Nutrition Society of New Zealand JF - Proceedings of the Nutrition Society of New Zealand Y1 - 1995/// VL - 20 SP - 89 EP - 95 SN - 0110-4187 AD - Nelson, R. G.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. N1 - Accession Number: 19961407058. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition N2 - A U-shaped relationship between diabetes prevalence and birth weight has been described in the Pima Indians with the highest diabetes prevalence in those with the lowest and highest birth weight. The increased risk of diabetes among those with a high birth weight can be explained largely by the presence of maternal diabetes during pregnancy. The increased risk among those with a low birth weight may be due to impaired development of the foetal pancreas associated with nutritional deprivation or to the selective survival of low birth-weight infants that are genetically susceptible to the development of diabetes. KW - birth weight KW - diabetes KW - ethnic groups KW - fetal development KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Proteins binding to the promoter region of the operon encoding the major outer surface proteins OspA and OspB of Borrelia burgdorferi. AU - Margolis, N. AU - Samuels, D. S. JO - Molecular Biology Reports JF - Molecular Biology Reports Y1 - 1995/// VL - 21 IS - 3 SP - 159 EP - 164 SN - 0301-4851 AD - Margolis, N.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19960504263. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - The synthesis of the major outer surface proteins OspA and OspB in B. burgdorferi varies among strains and during in vitro cultivation. B. burgdorferi CA-11.2A was examined for the presence of proteins that bind to the ospAB operon promoter region. 3 major DNA-protein complexes were detected using a mobility shift assay; one of these complexes was due to sequence-specific binding. These proteins may be involved in the regulation of ospAB transcription and the pathogenesis of Lyme disease. KW - binding proteins KW - DNA KW - human diseases KW - Lyme disease KW - molecular genetics KW - operons KW - proteins KW - transcription KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - biochemical genetics KW - carrier proteins KW - deoxyribonucleic acid KW - DNA transcription KW - lyme borreliosis KW - outer surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960504263&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sinusitis in children infected with human immunodeficiency virus: clinical characteristics, risk factors, and prophylaxis. AU - Mofenson, L. M. AU - Korelitz, J. AU - Pelton, S. AU - Moye, J. Jr. AU - Nugent, R. AU - Bethel, J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 21 IS - 5 SP - 1175 EP - 1181 SN - 1058-4838 AD - Mofenson, L. M.: Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Executive Building, Room 4B11, 6100 Executive Boulevard MSC 7510, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19962000501. Publication Type: Journal Article. Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group. Language: English. Number of References: 30 ref. KW - children KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - opportunistic infections KW - sinusitis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000501&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases. AU - Ross, J. P. AU - Holland, S. M. AU - Gill, V. J. AU - DeCarlo, E. S. AU - Gallin, J. I. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1995/// VL - 21 IS - 5 SP - 1291 EP - 1293 SN - 1058-4838 AD - Ross, J. P.: Laboratories of Host Defenses and Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19962004452. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health N2 - A report of 2 cases in men aged 22 and 34 years in the USA. KW - bacterial diseases KW - case reports KW - epidemiology KW - human diseases KW - infections KW - North America KW - USA KW - Burkholderia gladioli KW - man KW - Burkholderia KW - Burkholderiaceae KW - Burkholderiales KW - Betaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - Pseudomonas gladioli KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004452&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food choices of whites, blacks, and Hispanics: data from the 1987 National Health Interview Survey. AU - Patterson, B. H. AU - Harlan, L. C. AU - Block, G. AU - Kahle, L. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1995/// VL - 23 IS - 2 SP - 105 EP - 119 SN - 0163-5581 AD - Patterson, B. H.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7354, USA. N1 - Accession Number: 20001413039. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - An overview of the diets of whites, blacks and Hispanics is presented using data from the 1987 National Health Interview Survey (NHIS). Food frequency data from the 1987 NHIS on 20 143 adults were used to estimate the percentage of adults, by gender and race/ethnicity, who consume some 59 foods six or more times per year, median number of servings for consumers, and frequency of consumption of skin on poultry and fat on red meat. On the basis of percent consumption of these foods, women appear to have a more diverse diet than men. Women eat more fruits and vegetables, less meat, and fewer high-fat foods and drink fewer alcoholic beverages. Whites eat a more varied diet than blacks and Hispanics; blacks eat more fried and high-fat food; consumption of high-fat foods is lowest among Hispanics. Public health messages, especially those aimed at cancer prevention, should be targeted at increasing the overall consumption of fruits and vegetables, decreasing consumption of high-fat foods, especially among white and black men, and increasing consumption of those healthful foods already consumed by particular race/ethnicity groups. KW - alcoholic beverages KW - beverages KW - blacks KW - Caucasian KW - consumers KW - diet studies KW - ethnic groups KW - food consumption KW - foods KW - fruits KW - guidelines KW - health KW - Hispanics KW - mortality KW - neoplasms KW - poultry KW - prevention KW - public health KW - reviews KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - death rate KW - domesticated birds KW - drinks KW - recommendations KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413039&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type-1 integrase. AU - Mazumder, A. AU - Pommier, Y. JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1995/// VL - 23 IS - 15 SP - 2865 EP - 2871 SN - 0305-1048 AD - Mazumder, A.: Correspondence address: Y. Pommier, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 37, Room 5C25, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001501. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 951-78-0. KW - acquired immune deficiency syndrome KW - catalytic activity KW - deoxyuridine KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - nucleotides KW - substrates KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - integrase KW - reverse transciptase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001501&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - AIDS and cancer registry linkage: measurement and enhancement of registry completeness. AU - Coté, T. R. AU - O'Brien, T. R. AU - Ward, J. W. AU - Wilson, S. E. AU - Blattner, W. A. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1995/// VL - 24 IS - 4 SP - 375 EP - 377 SN - 0091-7435 AD - Coté, T. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19952009862. Publication Type: Journal Article. Corporate Author: USA, National AIDS/Cancer Match Study Group Language: English. Number of References: 9 refs. KW - acquired immune deficiency syndrome KW - epidemiology KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - registration KW - statistics KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cancers KW - human immunodeficiency virus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009862&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). AU - Kozak, C. A. AU - Gatignol, A. AU - Graham, K. AU - Jeang, K. T. AU - McBride, O. W. JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1995/// VL - 25 IS - 1 SP - 66 EP - 72 SN - 0888-7543 AD - Kozak, C. A.: Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950102735. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Agricultural Biotechnology N2 - Infection with the HIV-1 virus requires the involvement of host cell factors. The identification of these and the elucidation of their specific functions has been difficult. A human cDNA, TRBP, was previously cloned and characterized as a positive regulator of gene expression that binds to the TAR region of the HIV-1 genome. In this study this factor was shown to be encoded by a gene, TARBP2, that maps to human chromosome 12 and mouse chromosome 15, and 1 human pseudogene (TARBP2P) and 2 mouse TRBP-related sequences (Tarbp2-rs1, Tarbp2-rs2) were identified and mapped. The map location of the expressed gene identifies it as a candidate for the previously identified factor encoded on human chromosome 12 that has been shown to be important for expression of HIV-1 genes. Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells. KW - biotechnology KW - diseases KW - DNA binding proteins KW - gene mapping KW - genetic mapping KW - human immunodeficiency viruses KW - protein KW - Human immunodeficiency virus 1 KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102735&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3. AU - Patel, A. AU - Rochelle, J. M. AU - Jones, J. M. AU - Sumegi, J. AU - Uhl, G. R. AU - Seldin, M. F. AU - Meisler, M. H. AU - Gregor, P. JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1995/// VL - 25 IS - 1 SP - 314 EP - 317 SN - 0888-7543 AD - Patel, A.: Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Box 5180, Baltimore, MD 21224, USA. N1 - Accession Number: 19950102857. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 107-35-7. Subject Subsets: Agricultural Biotechnology N2 - The gene encoding the taurine transporter, Taut, was mapped to the central region of mouse chromosome 6. By analysing a cross that segregated the neurological mutant mnd2, Taut was excluded as a candidate gene for this closely linked mutation. To map the human taurine transporter gene, TAUT, a sequence-tagged site (STS) corresponding to the 3′ untranslated region of the human cDNA was developed. TAUT was assigned to human chromosome 3 by typing this STS on a panel of somatic cell hybrids. Further analysis of a hybrid panel containing defined deletions of chromosome 3 suggested that TAUT maps to 3p21-p25. These data extend a conserved linkage group on mouse chromosome 6 and human chromosome 3p. Deletion of TAUT might contribute to some phenotypic features of the 3p- syndrome. KW - biotechnology KW - gene mapping KW - mapping KW - neurotransmitters KW - taurine KW - transporters KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cartography KW - implement trailers KW - implement transporters KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950102857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro anti-HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: implications for its combined use with AZT or ddI. AU - Chokekijchai, S. AU - Shirasaka, T. AU - Weinstein, J. N. AU - Mitsuya, H. JO - Antiviral Research JF - Antiviral Research Y1 - 1995/// VL - 28 IS - 1 SP - 25 EP - 38 SN - 0166-3542 AD - Chokekijchai, S.: Correspondence address: H. Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009153. Publication Type: Journal Article. Language: English. Number of References: 35 ref. KW - acquired immune deficiency syndrome KW - analogues KW - antiviral agents KW - combination therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - nucleoside analogues KW - nucleosides KW - proteinase inhibitors KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - analogs KW - combined modality therapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - multimodal treatment KW - nucleoside analogs KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009153&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2′,3′-dideoxy-3′-thiacytidine. AU - Kavlick, M. AU - Shirasaka, T. AU - Kojima, E. AU - Pluda, J. M. AU - Hui, F. Jr AU - Yarchoan, R. AU - Mitsuya, H. JO - Antiviral Research JF - Antiviral Research Y1 - 1995/// VL - 28 IS - 2 SP - 133 EP - 146 SN - 0166-3542 AD - Kavlick, M.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002701. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 134678-17-4. KW - analogues KW - drug resistance KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lamivudine KW - nucleoside analogues KW - nucleosides KW - therapy KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 3TC KW - analogs KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - nucleoside analogs KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002701&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The Polycomb and trithorax group proteins of Drosophila: Trans-regulators of homeotic gene function. AU - Kennison, J. A. JO - Annual Review of Genetics JF - Annual Review of Genetics Y1 - 1995/// VL - 29 SP - 289 EP - 303 SN - 0066-4197 AD - Kennison, J. A.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2785, USA. N1 - Accession Number: 19970501287. Publication Type: Journal Article. Language: English. Number of References: 82 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology N2 - The Polycomb and trithorax group genes encode trans-regulators of homeotic gene function in Drosophila. The Polycomb group genes encode transcriptional repressors, while the trithorax group proteins are positive factors required for homeotic gene function. Among the Polycomb group proteins, the POLYCOMB protein has been most extensively characterized. The POLYCOMB protein contains a chromodomain, a conserved domain found in a Drosophila protein with effects on position-effect variegation. Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that modifies chromatin to facilitate the transcriptional activation by gene-specific DNA-binding proteins. The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins. KW - agricultural entomology KW - genes KW - genetics KW - homeotic genes KW - molecular genetics KW - proteins KW - regulation KW - reviews KW - arthropods KW - Drosophila KW - invertebrates KW - animals KW - eukaryotes KW - Drosophilidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - biochemical genetics KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501287&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Porphyria cutanea tarda in hepatitis C virus-infected blood donors. AU - Conry-Cantilena, C. AU - Vilamidou, L. AU - Melpolder, J. C. AU - VanRaden, M. AU - Alter, H. J. JO - Journal of the American Academy of Dermatology JF - Journal of the American Academy of Dermatology Y1 - 1995/// VL - 32 IS - 3 SP - 512 EP - 514 SN - 0190-9622 AD - Conry-Cantilena, C.: Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002869. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health N2 - A report of two cases. KW - blood donors KW - case reports KW - hepatitis C KW - human diseases KW - porphyria cutanea tarda KW - Maryland KW - North America KW - USA KW - hepatitis C virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002869&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection and quantitation of the glucuronoxylomannan-like polysaccharide antigen from clinical and nonclinical isolates of Trichosporon beigelii and implications for pathogenicity. AU - Lyman, C. A. AU - Devi, S. J. N. AU - Nathanson, J. AU - Frasch, C. E. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 1 SP - 126 EP - 130 SN - 0095-1137 AD - Lyman, C. A.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951201349. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - The amounts of antigen produced and the expression of O-acetyl epitopes from 35 T. beigelii strs. isolated from deep and superficial infections in patients in the USA were studied. By counterimmunoelectrophoresis, 10 of 10 isolates from deep infections were positive for polysaccharide, compared with 7 of 13 isolates from superficial infections (P=0.02). All 23 strs. tested were positive for polysaccharide when screened by immunodot. By enzyme immunoassay, the cross-reactive antigen produced by deep isolates (n=9) had a mean titre of 1:5500. In contrast, superficial isolates (n=22) produced significantly less antigen than the deep isolates (P<0.001), with a mean titre of 1:700. Isolates from environmental sources (n=3) were similar to the superficial isolates, with a mean titre of 1:600. The mean concn of cross-reactive polysaccharide released by deep isolates and superficial isolates were 3.09±0.44 and 1.74±0.30 µg/ml, respectively, when measured by rocket immunoelectrophoresis (P=0.02). O-Acetyl epitopes were detected on polysaccharide from 8 of 9 T. beigelii strs. isolated from deep sources, while only 2 of 12 superficial isolates expressed detectable O-acetyl epitopes (P=0.01). It is concluded that while all isolates of T. beigelii tested were capable of producing glucuronoxylomannan-like cross-reactive antigen, pathogenic isolates produced significantly more antigen than superficial or environmental isolates. Significantly more pathogenic isolates than superficial or environmental isolates expressed antigen that was O acetylated. KW - antigens KW - cross reaction KW - hosts KW - human diseases KW - immunology KW - infections KW - mycoses KW - pathogenicity KW - polysaccharides KW - USA KW - man KW - Trichosporon KW - Trichosporon beigelii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - Trichosporon KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - complex carbohydrates KW - fungus KW - Hyphomycetes KW - immunogens KW - trichosporonosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201349&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - PCR amplification of rRNA intergenic spacer regions as a method for epidemiologic typing of Clostridium difficile. AU - Cartwright, C. P. AU - Stock, F. AU - Beekmann, S. E. AU - Williams, E. C. AU - Gill, V. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 1 SP - 184 EP - 187 SN - 0095-1137 AD - Cartwright, C. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnusson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19952002445. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health N2 - From January to March 1993, a suspected outbreak of antibiotic-associated diarrhoea occurred on a paediatric oncology ward of the Clinical Center Hospital at the National Institutes of Health. Isolates of Clostridium difficile obtained from 6 patients implicated in this outbreak were typed by both PCR amplification of rRNA intergenic spacer regions (PCR ribotyping) and restriction endonuclease analysis of genomic DNA. Comparable results were obtained with both methods; five of the 6 patients were infected with the same strain of Cl. difficile. Subsequent analysis of 102 of Cl. difficile isolates obtained from symptomatic patients throughout the Clinical Center revealed the existence of 41 distinct and reproducible PCR ribotypes. These data suggest that PCR ribotyping provides a discriminatory, reproducible, and simple alternative to conventional molecular approaches for typing strains of Cl. difficile. KW - diarrhoea KW - human diseases KW - infections KW - polymerase chain reaction KW - strains KW - Maryland KW - North America KW - USA KW - Clostridium difficile KW - man KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - diarrhea KW - PCR KW - scouring KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of increasing inoculum sizes of pathogenic filamentous fungi on MICs of antifungal agents by broth microdilution method. AU - Gehrt, A. AU - Peter, J. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 5 SP - 1302 EP - 1307 SN - 0095-1137 AD - Gehrt, A.: Mycology Unit, Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951202337. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1397-89-3, 2022-85-7, 84625-61-6, 22916-47-8. Subject Subsets: Medical & Veterinary Mycology N2 - The influence of different inoculum sizes on min. inhibitory concn (MIC) of amphotericin B, 5-fluorocytosine [flucytosine], itraconazole and miconazole was investigated by the broth microdilution method using 32 clinical isolates (8 Aspergillus fumigatus, 8 A. flavus, 5 Rhizopus arrhizus, 8 Pseudallescheria boydii and 3 Fusarium solani). Four inoculum sizes were studied: 1 × 10²-5 × 10², 1 × 10³-5 × 10³, 1 × 104-5 × 104 and 1 × 105-5 × 105 colony forming units (CFU)/ml. The NCCLS reference method for antifungal susceptibility testing in yeasts was modified and applied to filamentous fungi. The inoculum was spectrophotometrically adjusted and all tests were performed in buffered medium (RPMI 1640) at pH 7.0 with incubation at 35°C for 72 h. MIC were read at 24, 48 and 72 h. Amphotericin B showed a min. effect of inoculum size on MIC for all species with the exception of P. boydii (P<0.05). A significant effect of inoculum size on MIC was observed with flucytosine, for which there was an increase of >10-fold in MIC against all Aspergillus spp. between inoculum concn of 10² and 104 CFU/ml (P<0.001). For itraconazole, the results showed a more species-dependent increase of MIC, especially for R. arrhizus and P. boydii. Miconazole, which was tested only with P. boydii, did not demonstrate a significant effect of inoculum size on MIC. It is concluded that the effect of inoculum size on MIC for filamentous fungi is dependent upon the organism and antifungal compound tested. Itraconazole and flucytosine demonstrated significant inoculum effects, while amphotericin B and miconazole showed comparatively minimum inoculum effects against pathogenic filamentous fungi. P. boydii and R. arrhizus showed the greatest inoculum effect. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - flucytosine KW - itraconazole KW - miconazole KW - techniques KW - Aspergillus flavus KW - Aspergillus fumigatus KW - fungi KW - Haematonectria haematococca KW - Mucoraceae KW - Pseudallescheria boydii KW - Rhizopus arrhizus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Fusarium KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Rhizopus KW - Mucoraceae KW - Mucorales KW - Mucoromycotina KW - Zygomycota KW - Haematonectria KW - 5-fluorocytosine KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - Fusarium solani KW - Hyphomycetes KW - susceptibility testing KW - Pesticides and Drugs (General) (HH400) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202337&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of Microsporidia in stool specimens by using PCR and restriction endonucleases. AU - Fedorko, D. P. AU - Nelson, N. A. AU - Cartwright, C. P. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 7 SP - 1739 EP - 1741 SN - 0095-1137 AD - Fedorko, D. P.: Microbiology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960801066. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology N2 - A PCR-based assay was developed for the detection of Microspora in clinical specimens. A single primer pair complementary to conserved sequences of the small-subunit rRNA enabled amplification of DNA from the 4 major microsporan pathogens of humans: Encephalitozoon cuniculi, Encephalitozoon hellem, Enterocytozoon bieneusi and Septata intestinalis. The extraction method allowed PCR amplification of E. bieneusi and S. intestinalis DNA from sodium hypochlorite-treated stool specimens. Differentiation between E. bieneusi and S. intestinalis was accomplished by restriction endonuclease digestion of PCR products using PstI and HaeIII. KW - diagnosis KW - DNA KW - faeces KW - gastrointestinal diseases KW - human diseases KW - immunocompromised hosts KW - opportunistic infections KW - parasites KW - polymerase chain reaction KW - protozoal infections KW - restriction endonuclease analysis KW - restriction endonucleases KW - Encephalitozoon intestinalis KW - Enterocytozoon bieneusi KW - man KW - Microspora KW - protozoa KW - Encephalitozoon KW - Encephalitozoonidae KW - Microspora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Enterocytozoon KW - Enterocytozoonidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - deoxyribonucleic acid KW - feces KW - PCR KW - protozoal diseases KW - Septata intestinalis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801066&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diversity of DNA fingerprints in Cryptococcus neoformans. AU - Varma, A. AU - Swinne, D. AU - Staib, F. AU - Bennett, J. E. AU - Kwon-Chung, K. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 7 SP - 1807 EP - 1814 SN - 0095-1137 AD - Varma, A.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19961201159. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology N2 - DNA fingerprint patterns of 156 C. neoformans isolates (26 AIDS patients, 46 non-AIDS patients and 40 environmental sources) from both varieties (126 C. neoformans var. neoformans and 30 C. neoformans var. gattii isolates) and from 7 countries were analysed by using the DNA probe UT-4p. Nine and 12 distinct DNA fingerprint patterns were observed for isolates of C. neoformans and C. neoformans var. gattii, respectively. No pattern was unique to AIDS patients, non-AIDS patients or the environment. Pattern II was observed more often in non-AIDS patients (8 of 23) than in AIDS patients (0 of 25). Pattern V was the most prevalent pattern (42 of 82) in clinical and environmental isolates. Isolates from 3 AIDS patients in Burundi and Zaire exhibited patterns identical to each other but different from those of isolates collected from their houses (dust of floors, walls) or a nearby pigeon coop. DNA fingerprint stability was determined for 53 isolates from 9 non-AIDS patients at different time intervals during 5 to 128 wk of antifungal therapy. For 8 patients, the fingerprint pattern was stable while the 9th may have had a mixed infection. Pattern II was observed in 4 of 9 patients, which was similar to 4 of 14 in other non-AIDS patients as reported here. In spite of the extensive pattern heterogeneity among 15 C. neoformans var. gattii isolates in Australia, the patterns observed in 7 California isolates were quite different from those in Australia. Among isolates of C. neoformans var. gattii, one fingerprint pattern (designated b) was observed in several countries of the Far East. The fingerprint patterns of 2 of 3 environmental isolates from Eucalyptus camaldulensis trees in Australia were identical to those of 2 of the 12 clinical isolates from that country. KW - acquired immune deficiency syndrome KW - contamination KW - cryptococcosis KW - DNA fingerprinting KW - epidemiology KW - genetics KW - genotypes KW - homes KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - opportunistic infections KW - predisposition KW - Australia KW - Burundi KW - California KW - Congo Democratic Republic KW - USA KW - Cryptococcus gattii KW - Cryptococcus neoformans KW - Eucalyptus KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus neoformans KW - Myrtaceae KW - Myrtales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - Pacific States of USA KW - Western States of USA KW - USA KW - North America KW - America KW - AIDS KW - Cryptococcus neoformans var. gattii KW - european blastomycosis KW - fungus KW - United States of America KW - Zaire KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201159&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mycoplasma pneumoniae and Mycoplasma genitalium mixture in synovial fluid isolate. AU - Tully, J. G. AU - Rose, D. I. AU - Baseman, J. B. AU - Dallo, S. F. AU - Lazzell, A. L. AU - Davis, C. P. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 7 SP - 1851 EP - 1855 SN - 0095-1137 AD - Tully, J. G.: Mycoplasma Section, National Institute of Allergy and Infectious Diseases, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19952007130. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health N2 - A mycoplasma cultured from synovial fluid specimens from a patient with pneumonia and subsequent polyarthritis was identified initially as Mycoplasma pneumoniae. In retrospective studies, the culture was shown also to contain M. genitalium. In this paper, the laboratory techniques employed in the identification and separation of the 2 species are presented, and evidence to implicate post-infectious autoimmunity is provided. An increasing number of reports of M. genitalium in human tissue sites and difficulties in isolation and identification of the organism in the clinical laboratory suggest the need for more extensive application of rapid and specific detection systems for both M. genitalium and M. pneumoniae in the clinical laboratory. KW - differentiation KW - human diseases KW - immunofluorescence KW - man KW - Mycoplasma genitalium KW - Mycoplasma pneumoniae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycoplasma KW - Mycoplasmataceae KW - Mycoplasmatales KW - Mollicutes KW - Firmicutes KW - Bacteria KW - prokaryotes KW - bacterium KW - fluorescent antibody technique KW - IFAT KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007130&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantitative PCR for human herpesviruses 6 and 7. AU - Secchiero, P. AU - Zella, D. AU - Crowley, R. W. AU - Gallo, R. C. AU - Lusso, P. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 8 SP - 2124 EP - 2130 SN - 0095-1137 AD - Secchiero, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962003097. Publication Type: Journal Article. Language: English. Number of References: 47 ref. N2 - The authors developed a quantitative polymerase chain reaction (PCR) assay for the detection of human herpesvirus 6 (HHV-6) (variants A and B) and HHV-7 DNAs in clinical samples using a non-homologous internal standard (IS) for each virus that is coamplified with the wild-type target sequence in the same vial and with the same pair of primers. This method allows for a correction of the variability of efficiency of the PCR technique. A standard curve is constructed for each experiment by coamplification of known quantities of the cloned HHV-6 or HHV-7 target templates with the respective IS. Absolute quantitation of the test samples is then achieved by determining the viral target/IS ratio of the hybridization signals of the amplification products and plotting this value against the standard curve. Using this assay the authors quantitated the amount of HHV-6 or HHV-7 DNA in infected cell cultures and demonstrated an inhibitory effect of phosphobiformic acid on the replication of HHV-6 and HHV-7 in vitro. For the first clinical application of this procedure, the authors performed preliminary measurements of the loads of HHV-6 and HHV-7 in lymph nodes from patients with Hodgkin's disease and AIDS. They conclude that application of this quantitative PCR method should be helpful for elucidating the pathogenic roles of HHV-6 and HHV-7. [The validity of quantitation of HHV-6 and HHV-7 DNA in clinical specimens as an approach to distinguishing latent from active infection with these agents totally depends on, as these authors state, latency being "associated with a low viral burden". However, they supply no evidence to support this statement. Longitudinally, the level of virus load in an individual patient is likely to change with the natural history of the viral disease and during administration of antiviral chemotherapy. It remains to be proved whether the amount of viral load in every patient with latent HHV-6 or HHV-7 infection will always be lower than that in every patient with active infection with these agents. Recent studies with serial CMV DNA detection in urine by PCR suggested that renal transplant patients with active rather than latent infection had higher maximal viral loads, but there was much overlap between the viral DNA concentrations in different patients at other times. (Journal of General Virology 1995; 76: 309-319).] D.J. Morris. KW - diagnosis KW - human diseases KW - infections KW - lymph nodes KW - polymerase chain reaction KW - human herpesvirus 6 KW - human herpesvirus 7 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003097&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - PCR and single-strand conformational polymorphism for recognition of medically important opportunistic fungi. AU - Walsh, T. J. AU - Francesconi, A. AU - Kasai, M. AU - Chanock, S. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1995/// VL - 33 IS - 12 SP - 3216 EP - 3220 SN - 0095-1137 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, 20892 MD, USA. N1 - Accession Number: 19951203445. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Polymerase chain reaction (PCR) has been shown to be useful for the detection of the presence of fungal DNA in both laboratory and clinical samples. Considerable interest has been focused on the utility of selecting universal primers, those that recognize constant regions among most medically important fungi. Once an amplicon, or piece of amplified DNA determined by the unique pair of oligonucleotide primers, has been generated, several different methods may be used to distinguish between genera and between species. The 2 major approaches have utilized differences in restriction enzyme digestion patterns or hybridization with specific probe. The application of single-strand conformational polymorphism (SSCP) as a technique to delineate the differences between fungal species and/or genera is described. Minor sequence variations in small single-stranded DNA cause subtle changes in conformation, allowing these strands to be separated on polyacrylamide gels by SSCP. A 197-bp fragment amplified from the 18S rRNA gene, common to all medically important fungi, was used. After amplification, the fragments were denatured and run on an acrylamide-glycerol gel at room temp. or 4°C for 4.5 or 4 h, respectively. Under room temp. conditions, the SSCP patterns for Candida albicans, C. tropicalis and C. parapsilosis were identical and all strains within each species demonstrated the same pattern. These patterns differed markedly from those of the genus Aspergillus. The SSCP patterns of major and minor bands at room temp. permitted distinction between strains of A. fumigatus and A. flavus. There was also consistency of the SSCP banding pattern among different strains of the same Aspergillus sp. The SSCP patterns for other medically important opportunistic fungi, such as Cryptococcus neoformans, Pseudallescheria boydii and Rhizopus arrhizus, were sufficiently unique to permit distinction from those of Candida albicans and A. fumigatus. It is concluded that the technique of PCR-SSCP provides a novel method by which to recognize and distinguish medically important opportunistic fungi and which has potential applications to molecular diagnosis, taxonomic classification, molecular epidemiology and elucidation of mechanisms of antifungal drug resistance. KW - identification KW - polymerase chain reaction KW - techniques KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Candida albicans KW - Candida parapsilosis KW - Candida tropicalis KW - Cryptococcus neoformans KW - Mucoraceae KW - Pseudallescheria boydii KW - Rhizopus arrhizus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Sordariomycetes KW - Rhizopus KW - Mucoraceae KW - Mucorales KW - Mucoromycotina KW - Zygomycota KW - fungus KW - Hyphomycetes KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) and International Cooperative Biodiversity Group (ICBG) programs. AU - Suffness, M. AU - Cragg, G. M. AU - Grever, M. R. AU - Grifo, F. J. AU - Johnson, G. AU - Mead, J. A. R. AU - Schepartz, S. A. AU - Venditti, J. M. AU - Wolpert, M. A2 - Valeriote, F. A2 - Pezzuto, J. JO - International Journal of Pharmacognosy JF - International Journal of Pharmacognosy Y1 - 1995/// VL - 33 IS - SUPPL SP - 5 EP - 16 SN - 0925-1618 AD - Suffness, M.: Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19960300453. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 2 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - The high interest in natural products as sources of pharmaceutical products led to the creation of the NCNPDDG programme by the National Cancer Institute with the goal of bringing together scientists from academia, industry and government in a focused effort for discovery of new drugs for cancer treatment. Similarly, the National Institutes of Health, the National Science Foundation, and the US Agency for International Development have joined together to form the ICBG programme to promote the goals of biodiversity conservation, economic development and pharmaceutical discovery. Both programmes are briefly described. KW - antineoplastic agents KW - antineoplastic properties KW - biodiversity KW - conservation KW - development agencies KW - government organizations KW - natural products KW - research KW - anti-neoplastic properties KW - cytotoxic agents KW - Drug discovery and development KW - studies KW - Plant Science (General) (FF000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960300453&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary intake changes associated with post-cyclone food aid in Western Somoa. AU - Galanis, D. J. AU - Chin-Hong, P. V. AU - McGarvey, S. T. AU - Messet, E. AU - Parkinson, D. JO - Ecology of Food and Nutrition JF - Ecology of Food and Nutrition Y1 - 1995/// VL - 34 IS - 2 SP - 137 EP - 147 SN - 0367-0244 AD - Galanis, D. J.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951414151. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology; Rural Development N2 - This study examines dietary intake responses to a food aid programme in Western Samoa, which consisted primarily of rice and flour supplements. Using a semi-quantitative food frequency questionnaire, intake estimates were made for 147 Samoans (72 men, 75 women; 25-55 years old), 5 months before and 8 months after a tropical cyclone. Study participants were from urban Apia (n=34) and 3 rural, more traditional villages (n=113). For the total sample, consumption of rice and pancakes more than doubled, and the contribution of these foods to total carbohydrate and energy intake increased about 3-fold (P<0.0001). Significant decreases were noted for the nutrient contribution from breadfruit and coconut products. These dietary changes were significantly less in the urban sub-sample. These results indicate the food aid may have accelerated an existing modernizing trend in the diet of Samoans. The nutritional and economic implications are discussed within the context of Western Samoa. KW - diet studies KW - food aid KW - natural disasters KW - nutrition programmes KW - rural development KW - Samoa KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - Polynesia KW - Oceania KW - Pacific Islands KW - feeding programmes KW - feeding programs KW - food programs KW - nutrition programs KW - Western Samoa KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000) KW - Diet Studies (VV110) KW - Consumer Economics (EE720) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414151&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase. AU - Mazumder, A. AU - Gazit, A. AU - Levitzki, A. AU - Nicklaus, M. AU - Yung, J. AU - Kohlhagen, G. AU - Pommier, Y. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1995/// VL - 34 IS - 46 SP - 15111 EP - 15122 SN - 0006-2960 AD - Mazumder, A.: Laboratories of Molecular Pharmacology and Medicinal Chemistry, Division of Basic Science, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006413. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9026-43-1. KW - antiviral agents KW - antiviral properties KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - protein kinase KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - integrase KW - tyrphostins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006413&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of novel differentially expressed hepatic genes in cholesterol-fed rabbits by a non-targeted gene approach. AU - Remaley, A. T. AU - Schumacher, U. K. AU - Amouzadeh, H. R. AU - Brewer, H. B., Jr. AU - Hoeg, J. M. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1995/// VL - 36 IS - 2 SP - 308 EP - 314 SN - 0022-2275 AD - Remaley, A. T.: National Heart, Lung, and Blood Institute, National Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19951404532. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The effect of cholesterol on gene expression was investigated in differentially expressed genes from the polymerase chain reaction (PCR) based subtraction library prepared from the liver of chow fed and cholesterol fed rabbits. 9 upregulated and 4 downregulated cDNA fragments were isolated. As determined by Northern blot analysis, the expression of the isolated cDNAs began to change as early as the first week on the cholesterol rich diet or as late as 4 weeks, which corresponded with hepatic cholesterol accumulation. 3 of the cDNAs were identified by DNA sequence homology, whereas the remaining cDNAs had no significant homology match. CYP1A1, a cytochrome P450 isoenzyme, was found to be downregulated in hepatocytes by cholesterol feeding. Osteopontin and Mac-2, which are produced by macrophages, were found to be upregulated in Kupffer cells by cholesterol feeding. Overall results demonstrate the usefulness of the subtraction library approach for identifying new candidate genes for exploring the pathogenesis of atherosclerosis. KW - atherosclerosis KW - cholesterol KW - gene expression KW - genes KW - identification KW - intake KW - liver KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404532&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Maternal-fetal interactions affect growth of human immunodeficiency virus type 1 transgenic mice. AU - Franks, R. R. AU - Ray, P. E. AU - Babbott, C. C. AU - Bryant, J. L. AU - Notkins, A. L. AU - Santoro, T. J. AU - Klotman, P. E. JO - Pediatric Research JF - Pediatric Research Y1 - 1995/// VL - 37 IS - 1 SP - 56 EP - 63 SN - 0031-3998 AD - Franks, R. R.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003111. Publication Type: Journal Article. Language: English. Number of References: 59 ref. KW - animal models KW - HIV infections KW - interactions KW - maternal transmission KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus infections KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003111&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupational risks for cutaneous melanoma among men in Sweden. AU - Linet, M. S. AU - Malker, H. S. R. AU - Chow WongHo AU - McLaughlin, J. K. AU - Weiner, J. A. AU - Stone, B. J. AU - Ericsson, J. L. E. AU - Fraumeni, J. F., Jr. JO - Journal of Occupational and Environmental Medicine JF - Journal of Occupational and Environmental Medicine Y1 - 1995/// VL - 37 IS - 9 SP - 1127 EP - 1135 AD - Linet, M. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, EPN 415, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19962004976. Publication Type: Journal Article. Language: English. Number of References: 81 ref. Subject Subsets: Public Health N2 - A population-based linked-registry was used to evaluate incidence of malignant melanoma of the skin among Swedish men by industry and occupation. There were 3850 cutaneous melanoma cases identified in the 19-year follow-up of men employed in 1960. New associations were observed for men employed in the breweries and malt-processing industry and in shoe fabrication from leather and skins. Several findings supported associations previously reported in other countries, including an excess risk among workers in basic chemical production and the printing industry and among professional, technical, and white-collar workers. Risk overall was not increased among farmers, despite a significant excess of melanoma of the face, neck, and scalp. Although this linked registry analysis lacked information about specific agents, duration of employment, and occupational and recreational sun exposures, it did provide leads for new associations and confirmed previous ones. Nevertheless, because of these limitations, aetiological clues must be interpreted cautiously. KW - cutaneous melanoma KW - epidemiology KW - human diseases KW - men KW - neoplasms KW - occupational health KW - occupations KW - risk factors KW - workers KW - Europe KW - Sweden KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004976&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacokinetics of michellamine B, a naphthylisoquinoline alkaloid with in vitro activity against human immunodeficiency virus types 1 and 2, in the mouse and dog. AU - Supko, J. G. AU - Malspeis, L. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 1 SP - 9 EP - 14 SN - 0066-4804 AD - Supko, J. G.: Laboratory of Pharmaceutical Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701, USA. N1 - Accession Number: 19952005309. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - Concentrations of the naphthylisoquinoline alkaloid that were effective against HIV-1 and HIV-2 in vitro were achievable in mice and dogs after intravenous administration without toxicity. Metabolic pathways could not be elucidated. KW - alkaloids KW - antiviral agents KW - human immunodeficiency viruses KW - isoquinoline alkaloids KW - natural products KW - pharmacokinetics KW - plant products KW - toxicity KW - animals KW - dogs KW - man KW - mice KW - eukaryotes KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - Muridae KW - rodents KW - crop products KW - human immunodeficiency virus KW - michellamine B KW - naphthylisoquinolines KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005309&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms. AU - McMahon, J. B. AU - Currens, M. J. AU - Gulakowski, R. J. AU - Buckheit, R. W. Jr AU - Lackman-Smith, C. AU - Hallock, Y. F. AU - Boyd, M. R. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 2 SP - 484 EP - 488 SN - 0066-4804 AD - McMahon, J. B.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19952005316. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - A new dimeric alkaloid (extracted from the aerial parts of the tropical vine Ancistrocladus korupensis) was found to act at two stages of the HIV life cycle. It inhibited RTase and human DNA polymerases α and β as well as cell fusion and syncytium formation when added up to 48 h after acute infection, but complete inhibition of viral replication occurred only when it was added immediately after infection. Fully established cell infections were not affected by michellamine B. KW - alkaloids KW - antiviral agents KW - antiviral plants KW - antiviral properties KW - human immunodeficiency viruses KW - medicinal plants KW - natural products KW - pharmacokinetics KW - plant products KW - toxicity KW - Ancistrocladaceae KW - Ancistrocladus korupensis KW - man KW - plants KW - Theales KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Ancistrocladus KW - Ancistrocladaceae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-viral properties KW - crop products KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - michellamine B KW - naphthylisoquinolines KW - officinal plants KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Plant Composition (FF040) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. AU - Polis, M. A. AU - Spooner, K. M. AU - Baird, B. F. AU - Manischewitz, J. F. AU - Jaffe, H. S. AU - Fisher, P. E. AU - Falloon, J. AU - Davey, R. T., Jr. AU - Kovacs, J. A. AU - Walker, R. E. AU - Whitcup, S. M. AU - Nussenblatt, R. B. AU - Lane, H. C. AU - Masur, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 4 SP - 882 EP - 886 SN - 0066-4804 AD - Polis, M. A.: National Institute of Allergy and Infectious Diseases, Building 10, Room 11C103, Bethesda, MD 20892, USA. N1 - Accession Number: 19952006120. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 113852-37-2. KW - acquired immune deficiency syndrome KW - adverse effects KW - analogues KW - antiviral agents KW - cidofovir KW - HIV infections KW - human diseases KW - infections KW - nucleotides KW - pharmacokinetics KW - therapy KW - toxicity KW - treatment KW - cytomegalovirus KW - man KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AIDS KW - analogs KW - human immunodeficiency virus infections KW - nucleotide analogues KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006120&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Therapeutic monitoring of experimental invasive pulmonary aspergillosis by ultrafast computerized tomography, a novel, noninvasive method for measuring responses to antifungal therapy. AU - Walsh, T. J. AU - Garrett, K. AU - Feuerstein, E. AU - Girton, M. AU - Allende, M. AU - Bacher, J. AU - Francesconi, A. AU - Schaufele, R. AU - Pizzo, P. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 5 SP - 1065 EP - 1069 SN - 0066-4804 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951202384. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The course of pulmonary infiltrates was monitored by serial ultrafast computerized tomography (UFCT) in persistently granulocytopenic rabbits with experimental invasive pulmonary aspergillosis. The course of pulmonary lesions measured by serial UFCT scans was compared with those measured by conventional chest radiography, histopathological resolution of lesions and microbiological clearance of Aspergillus fumigatus. Treatment groups included either amphotericin B colloidal dispersion in dosages of 1, 5 and 10 mg/kg of body wt daily intravenously or conventional desoxycholate amphotericin B at 1 mg/kg daily intravenously. Therapeutic monitoring of pulmonary lesions by UFCT demonstrated a significant dose-response relationship. Lesions continued to progress in untreated controls, whereas lesions in treated rabbits initially increased and then decreased in response to antifungal therapy in a dosage-dependent manner (P≤0.05 to P≤0.005, depending upon the groups compared). This same trend of resolution of lesions in response to antifungal therapy was also demonstrated by post-mortem examination and by microbiological clearance of the organism. The data indicated that amphotericin B colloidal dispersion at 5 and 10 mg/kg daily exerted a more rapid rate of clearance of lesions than conventional amphotericin B. UFCT was more sensitive than conventional chest radiography in detecting lesions due to invasive pulmonary aspergillosis (P<0.05 to P<0.005, depending upon the groups compared). These findings established a correlation among UFCT-defined lesions, microbiological response and resolution of pathologically defined lesions in experimental invasive pulmonary aspergillosis. It is concluded that aerial monitoring of UFCT-defined lesions of aspergillosis provides a novel system for determining the antifungal response of organism-mediated tissue injury. KW - administration KW - amphotericin B KW - antifungal agents KW - aspergillosis KW - computed tomography KW - diagnosis KW - drug formulations KW - drug therapy KW - experimental infections KW - infections KW - lipids KW - lungs KW - therapy KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - lipins KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951202384&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii. AU - Walsh, T. J. AU - Peter, J. AU - McGough, D. A. AU - Fothergill, A. W. AU - Rinaldi, M. G. AU - Pizzo, P. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 6 SP - 1361 EP - 1364 SN - 0066-4804 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200300. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 1397-89-3, 86386-73-4, 84625-61-6, 22916-47-8. Subject Subsets: Medical & Veterinary Mycology N2 - The in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole and fluconazole, against P. boydii, was determined. Combinations of amphotericin B and antifungal azoles were synergistic, additive or indifferent in their interaction against P. boydii. Antagonism was not observed. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - azoles KW - drug synergy KW - fluconazole KW - itraconazole KW - miconazole KW - synergism KW - Pseudallescheria boydii KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - susceptibility testing KW - synergy KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200300&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species. AU - Chokekijchai, S. AU - Kojima, E. AU - Anderson, S. AU - Nomizu, M. AU - Tanaka, M. AU - Machida, M. AU - Date, T. AU - Toyota, K. AU - Ishida, S. AU - Watanabe, K. AU - Yoshioka, H. AU - Roller, P. P. AU - Murakami, K. AU - Mitsuya, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 10 SP - 2345 EP - 2347 SN - 0066-4804 AD - Chokekijchai, S.: Correspondence address: H, Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008782. Publication Type: Journal Article. Language: English. Number of References: 12 ref. KW - acquired immune deficiency syndrome KW - antiviral agents KW - cell fusion KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inhibitors KW - oligopeptides KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogues in resting and activated peripheral blood mononuclear cells. AU - Shirasaka, T. AU - Chokekijchai, S. AU - Yamada, A. AU - Gosselin, G. AU - Imbach, J. L. AU - Mitsuya, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 11 SP - 2555 EP - 2559 SN - 0066-4804 AD - Shirasaka, T.: Correspondence address: H. Mitsuya, Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19962000613. Publication Type: Journal Article. Language: English. Number of References: 20 ref. KW - activity KW - analogues KW - antiviral agents KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - nucleoside analogues KW - nucleosides KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - analogs KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000613&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates. AU - Blaney, S. M. AU - Daniel, M. J. AU - Harker, A. J. AU - Godwin, K. AU - Balis, F. M. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1995/// VL - 39 IS - 12 SP - 2779 EP - 2782 SN - 0066-4804 AD - Blaney, S. M.: The Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007045. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 7841-89-2. KW - animal models KW - dideoxycytidine KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - pharmacokinetics KW - Macaca KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007045&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Are there alternative avian influenza viruses for generation of stable attenuated avian-human influenza A reassortant viruses? AU - Subbarao, K. AU - Webster, R. G. AU - Yoshihiro Kawaoka AU - Murphy, B. R. JO - Virus Research JF - Virus Research Y1 - 1995/// VL - 39 IS - 2/3 SP - 105 EP - 118 SN - 0168-1702 AD - Subbarao, K.: Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 106, 7 Center Drive MSC 0720, Bethesda, MD, USA. N1 - Accession Number: 19962213413. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Veterinary Science KW - avian influenza KW - avian influenza A viruses KW - avian influenza viruses KW - human diseases KW - influenza a KW - influenza viruses KW - live vaccines KW - viral diseases KW - Influenza A virus KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthomyxoviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Influenzavirus A KW - attenuated vaccines KW - avian influenzavirus KW - bird flu KW - bird grippe KW - bird influenza KW - fowl plague virus KW - influenzavirus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962213413&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helicobacter pylori infection. A reversible cause of hypergastrinemia and hyperchlorhydria which may mimic Zollinger-Ellison syndrome. AU - Metz, D. C. AU - Weber, H. C. AU - Orbuch, M. AU - Strader, D. B. AU - Lubensky, I. A. AU - Jensen, R. T. JO - Digestive Diseases and Sciences JF - Digestive Diseases and Sciences Y1 - 1995/// VL - 40 IS - 1 SP - 153 EP - 159 SN - 0163-2116 AD - Metz, D. C.: National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952002520. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health N2 - The cases of 2 males, aged 13 years and 34 years, from Maryland, USA. KW - case reports KW - human diseases KW - infection KW - infections KW - stomach KW - zollinger-ellison syndrome KW - Maryland KW - North America KW - USA KW - Helicobacter pylori KW - man KW - Helicobacter KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - hyperacidity (agricola) KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Distribution of genetic diversity in relation to chromosomal inversions in the malaria mosquito Anopheles gambiae. AU - Mathiopoulos, K. D. AU - Lanzaro, G. C. JO - Journal of Molecular Evolution JF - Journal of Molecular Evolution Y1 - 1995/// VL - 40 IS - 6 SP - 578 EP - 584 SN - 0022-2844 AD - Mathiopoulos, K. D.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960500902. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - The authors compared the genetic variation of areas inside and outside inversions in 2 distinct inversion karyotypes of A. gambiae. 35 cDNA clones were mapped on the 5 arms of the A. gambiae chromosomes with divisional probes. 16 of these clones, localized both inside and outside inversions of chromosome 2, were used as probes in order to determine the nucleotide diversity of different parts of the genome in the 2 inversion karyotypes. It was observed that the sequence diversity inside the inversion is >3-fold lower than in areas outside the inversion and that the degree of divergence increases gradually at loci at increasing distance from the inversion. To interpret the data, the authors present a selectionist and a stochastic model, both of which point to a relative recent origin of the studied inversion and may suggest differences between the evolutionary history of inversions in Anopheles and Drosophila species. KW - chromosome inversion KW - clones KW - cytogenetics KW - DNA KW - genetics KW - inversion polymorphism KW - models KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Candida glabrata, Candida krusei, non-albicans Candida spp., and other fungal organisms in a sixty-bed national cancer center in 1989-1993: no association with the use of fluconazole. AU - Kunová, A. AU - Trupl, J. AU - Špánik, S. AU - Drgona, L. AU - Šufliarsky, J. AU - Lacka, J. AU - Studená, V. AU - Hlaváčová, E. AU - Studená, M. AU - Kukučková, E. AU - Kollár, T. AU - Pichna, P. AU - Oravcová, E. AU - Krčméry, K., Jr. JO - Chemotherapy (Basel) JF - Chemotherapy (Basel) Y1 - 1995/// VL - 41 IS - 1 SP - 39 EP - 44 SN - 0009-3157 AD - Kunová, A.: Department of Microbiology, National Cancer Institute, Bratislava, Slovakia. N1 - Accession Number: 19951201775. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - During 1989-1993, the incidence of C. krusei and other non-albicans Candida spp. was analysed at the National Cancer Center, Bratislava, Slovakia. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%. After introduction of fluconazole into prophylaxis in acute leukaemia in 1991, the incidence of C. krusei was 12.7%. After 3 yr of fluconazole use in therapy and prophylaxis, the incidence of C. krusei in 1993 was 14.8%, which was lower than before fluconazole was introduced in Slovakia. 97.6% of all isolated fungi were yeasts and 2.4% were moulds. Among yeasts, the most frequently isolated pathogen was C. albicans with 64.3% in 1989 and 74.2% in 1993 followed by C. krusei with 21.2% in 1992 and 16.5% in 1989, but 14.8% in 1993. C. tropicalis and C. glabrata [Torulopsis glabrata] were isolated with frequencies of 9.03% in 1989 and 2.7% in 1993. Among the moulds, Aspergillus spp. were most frequently isolated. It is concluded that of these mycologically proven fungal infections confirmed by positive blood cultures or biopsies, C. albicans and Aspergillus spp. were the most common causative organisms. KW - aspergillosis KW - candidosis KW - drug therapy KW - epidemiology KW - fluconazole KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - neoplasms KW - opportunistic infections KW - predisposition KW - prophylaxis KW - therapy KW - Slovakia KW - Aspergillus KW - Candida KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida tropicalis KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Candida KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - cancers KW - Candida krusei KW - candidiasis KW - chemotherapy KW - fungus KW - Hyphomycetes KW - therapeutics KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201775&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration. AU - Yanagihara, R. AU - Saitou, N. AU - Nerurkar, V. R. AU - Song, K. J. AU - Bastian, I. AU - Franchini, G. AU - Gajdusek, D. C. JO - Cellular and Molecular Biology JF - Cellular and Molecular Biology Y1 - 1995/// VL - 41 IS - SUP 1 SP - S145 EP - S161 SN - 0145-5680 AD - Yanagihara, R.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 5B-21, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005475. Publication Type: Journal Article. Language: English. Number of References: 111 ref. Subject Subsets: Tropical Diseases N2 - Phylogenetic trees based on selected regions of the gag, pol, env and pX genes of HTLV-I from widely separated geographical regions and of simian T-cell lymphotropic virus type I (STLV-I) from African and Asian catarrhines, constructed using the neighbour-joining and maximum parsimony methods, indicated that the Australo-Melanesian and cosmopolitan strains of HTLV-I have evolved along separate geographically dependent lineages, with African STLV-I strains clustering with cosmopolitan HTLV-I strains and Asian STLV-I strains diverging from the common ancestral virus before the Australo-Melanesian HTLV-I strains. When viewed within the context of non-human primate evolution and human occupation of Australia and Melanesia, the rate of molecular change of HTLV-I and STLV-I is approximately 2.5-6.8 × 10-7 substitutions per site per year. Overall, the sequence and phylogenetic analyses are in accord with interspecies virus transmission among non-human primates, as well as between non-human primates and humans, with independent evolution of HTLV-I in Southeast Asia and in Africa, and with dissemination of HTLV-I by forced or voluntary movements of human populations. The immunosuppressive and T-cell activation properties of HTLV-I places at added risk these Australian Aboriginal and Melanesian populations, some of which are in imminent threat of infection with human immunodeficiency virus type 1. KW - evolution KW - HTLV infections KW - molecular biology KW - nucleotide sequences KW - phylogeny KW - Africa KW - Asia KW - Melanesia KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - retroviridae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Australasia KW - Oceania KW - Pacific Islands KW - DNA sequences KW - gene sequences KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of N-acetyl-β-hexosaminidase from Acanthamoeba castellanii. AU - Baldwin, K. M. AU - Bowers, B. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1995/// VL - 42 IS - 3 SP - 237 EP - 242 SN - 1066-5234 AD - Baldwin, K. M.: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, Bldg. 3, Rm B1-22, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950808083. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9027-52-5. Subject Subsets: Protozoology N2 - The lysosomal enzyme N-acetyl-β-hexosaminidase (βhex) was purified from Acanthamoeba castellanii growth medium by a 3 step procedure. The enzyme was precipitated with ammonium sulfate, partially purified on a DE52 column and purified to homogeneity on an affinity column. The purified βhex appeared to be a monomer of 58 000 MW with an isoelectric point of ~ 5.8. The enzyme activity in growth medium was stable for several months. The purified βhex was enzymatically deglycosylated and injected into 2 rabbits to make polyclonal antibodies. One antiserum was specific for βhex, but the other stained many bands on immunoblots of whole A. castellanii cell preparations. Using fluorescently-labelled secondary antibodies, it was shown that both antisera stained digestive vacuoles in the cytoplasm but did not stain the contractile vacuole. The multi-specific antiserum had high avidity for βhex but also stained the carbohydrate portion of other molecules. These other molecules may also be lysosomal enzymes since the activity of several other lysosomal enzymes was partially immunoprecipitable with the antiserum. These antibodies could be used to study traffic patterns among the variety of vacuolar structures in Acanthamoeba cytoplasm. KW - antibodies KW - beta-n-acetylhexosaminidase KW - biochemistry KW - cytoplasm KW - enzymes KW - lysosomes KW - organelles KW - parasites KW - purification KW - vacuoles KW - Acanthamoeba castellanii KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - hexosaminidase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808083&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis. AU - Diamond, L. S. AU - Clark, C. G. AU - Cunnick, C. C. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1995/// VL - 42 IS - 3 SP - 277 EP - 278 SN - 1066-5234 AD - Diamond, L. S.: Laboratory of Parasitic Diseases, NIAID, Bldg 4, Rm 126, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950808087. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9000-71-9. Subject Subsets: Protozoology N2 - Pancreatic digests of casein are major ingredients of media used in the axenic cultivation of lumen-dwelling parasitic protozoa, especially Entamoeba spp., Giardia intestinalis and trichomonads, including Trichomonas vaginalis. The digest used almost exclusively in the development of these media, Medo-Peptone (Trypticase BBL), has not been available since 1981. Tests of similar type digests have revealed none equal to Medo-Peptone, and it has become increasingly difficult to obtain new batches which will support even modest growth of E. histolytica. A casein-free medium (YI-S), consisting of a nutrient broth, vitamin mixture and serum, has been developed in response to this problem and is recommended as a replacement for the casein-dependent medium TYI-S-33. KW - casein KW - cell culture KW - culture media KW - culture techniques KW - in vitro culture KW - parasites KW - Entamoeba KW - Entamoeba histolytica KW - Giardia duodenalis KW - Giardia intestinalis KW - protozoa KW - Trichomonas vaginalis KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Trichomonas KW - Trichomonadidae KW - Trichomonadida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Other Invertebrate Culture (Not Aquaculture) (LL030) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808087&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of iron deficient anemia in infant rhesus macaques. AU - Kriete, M. F. AU - Champoux, M. AU - Suomi, S. J. JO - Laboratory Animal Science JF - Laboratory Animal Science Y1 - 1995/// VL - 45 IS - 1 SP - 15 EP - 21 SN - 0023-6764 AD - Kriete, M. F.: National Eye Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19952208524. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 7439-89-6. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science; Animal Nutrition; Human Nutrition N2 - A retrospective analysis of complete blood count data obtained from 56 rhesus macaque infants over a 5-month period was conducted. 14 infants were exclusively dam-reared, and 42 were nursery-reared. By 60 days of age, erythrocyte indices were lower in the dam-reared monkeys than in the nursery-reared animals. Between 90 to 150 days of age, an apparent iron deficiency anaemia developed in the dam-reared infants only. This anaemia was characterized as a microcytic, hypochromic anaemia. The time of onset of anaemia was comparable developmentally to that observed in exclusively breast-fed human infants. At no time were these infants clinically or behaviourally affected by the anaemia. Haematological status of the dams did not correlate with that of their infants. It could not be determined whether dam's parity was predictive of the development of anaemia in the infant. These observed phenomena in rhesus monkeys may serve as a potential non-human primate model for the anaemia that is observed in exclusively breast-fed human infants. KW - anaemia KW - artificial rearing KW - blood disorders KW - breast feeding KW - deficiency KW - deficiency diseases KW - disease models KW - diseases KW - infants KW - iron KW - iron deficiency anaemia KW - laboratory animals KW - trace elements KW - wild animals KW - Macaca KW - man KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - anemia KW - blood diseases KW - haematologic disorders KW - hand rearing KW - hematologic disorders KW - iron deficiency anemia KW - microelements KW - Laboratory Animal Science (LL040) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952208524&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spiroplasma ixodetis sp. nov., a new species from Ixodes pacificus ticks collected in Oregon. AU - Tully, J. G. AU - Rose, D. L. AU - Yunker, C. E. AU - Carle, P. AU - Bové, J. M. AU - Williamson, D. L. AU - Whitcomb, R. F. JO - International Journal of Systematic Bacteriology JF - International Journal of Systematic Bacteriology Y1 - 1995/// VL - 45 IS - 1 SP - 23 EP - 28 SN - 0020-7713 AD - Tully, J. G.: Mycoplasma Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Frederick Cancer Research Facility, Frederick, MD 21702, USA. N1 - Accession Number: 19950502477. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A total of 8 strains of mollicutes was isolated from pooled suspensions prepared from I. pacificus collected in Oregon, USA. Morphologic examination by electron and dark-field microscopic techniques showed that each strain consisted of a mixture of motile, tightly coiled helical cells, small coccoid cells with diameters ranging from 300 to 500 nm, and pleomorphic, straight or branched filamentous forms. All cellular forms were surrounded by a single cytoplasmic membrane, and there was no evidence of a cell wall. The organisms were filtered and fastidious in their growth requirements. The optimum temperature for growth was 30°C, but multiplication occurred at temperatures ranging from 23 to 32°C. The strains catabolized glucose but did not hydrolyse arginine or urea. The genome size of Y32T (T = type strain) was 2220 kbp, and the DNA base composition (guanine-plus-cytosine content) of this organism was 25±1 mol%. The 8 isolates were serologically related to each other but were not related to 37 other type or representative strains belonging to the genus Spiroplasma. Strain Y32 (= ATCC 33835) is the type strain of S. ixodetis sp. nov. KW - new species KW - symbionts KW - taxonomy KW - Oregon KW - USA KW - Acari KW - Arachnida KW - Entomoplasmatales KW - Ixodes pacificus KW - Ixodidae KW - Mollicutes KW - Spiroplasma KW - Spiroplasma ixodetis KW - Spiroplasmataceae KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Mollicutes KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Spiroplasmataceae KW - Entomoplasmatales KW - Spiroplasma KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - systematics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502477&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: genetic and phylogenetic evidence for common source of infection. AU - Nerurkar, V. R. AU - Achiron, A. AU - Song, K. J. AU - Melland, R. R. AU - Pinhas-Hamiel, O. AU - Melamed, E. AU - Shohat, B. AU - Yanagihara, R. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1995/// VL - 45 IS - 4 SP - 361 EP - 366 SN - 0146-6615 AD - Nerurkar, V. R.: Correspondence address: R. Yanagihara, National Institutes of Health, Bldg. 36, Rm. 5B21, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009640. Publication Type: Journal Article. Language: English. Number of References: 29 ref. KW - epidemiology KW - htlv-I infections KW - human diseases KW - phylogeny KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009640&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The U-shaped association between body mass index and mortality: relationship with weight gain in a native American population. AU - Hanson, R. L. AU - McCance, D. R. AU - Jacobsson, L. T. H. AU - Narayan, K. M. V. AU - Nelson, R. G. AU - Pettitt, D. J. AU - Bennett, P. H. AU - Knowler, W. C. JO - Journal of Clinical Epidemiology JF - Journal of Clinical Epidemiology Y1 - 1995/// VL - 48 IS - 7 SP - 903 EP - 916 SN - 0895-4356 AD - Hanson, R. L.: Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550E. Indian School Road, Phoenix, AZ 85014, USA. N1 - Accession Number: 19951409494. Publication Type: Journal Article. Language: English. Number of References: 86 ref. Subject Subsets: Human Nutrition N2 - To determine whether weight loss explains high mortality rates in those with a low body mass index (BMI), the relationship between BMI, rate of weight gain and mortality were examined in 814 diabetic and 1814 nondiabetic Pima Indians in a longitudinal survey with a mean duration of follow-up of 8.1 years. The participants had had at least 2 examinations after the age of 20 years. BMI showed a U-shaped relationship with mortality rates in men, while an inverse relationship was seen in women. Subjects who were losing weight had higher mortality rates that those who were gaining. However, excess mortality among the lightest subjects was present among those who were gaining weight. Among nondiabetic subjects, the mortality ratio (MR) for BMI <25 compared with 30-35 kg/m² was 1.5 unadjusted for weight gain, while the adjusted MR was 1.3. Weight loss, which may reflect underlying illness, was associated with high mortality rates in Pima Indians, but this did not fully account for the high mortality in the lightest individuals. KW - American Indians KW - body measurements KW - diabetes KW - ethnic groups KW - mortality KW - obesity KW - weight gain KW - weight losses KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - death rate KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409494&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of human immunodeficiency virus type-1 integrase by curcumin. AU - Mazumder, A. AU - Raghaven, K. AU - Weinstein, J. AU - Kohn, K. W. AU - Pommier, Y. JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1995/// VL - 49 IS - 8 SP - 1165 EP - 1170 SN - 0006-2952 AD - Mazumder, A.: Correspondence address: Y. Pommier, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962002085. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 458-37-7. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants KW - antiviral properties KW - curcumin KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - phenylpropanoids KW - structure KW - turmeric KW - Curcuma longa KW - Human immunodeficiency virus 1 KW - man KW - Curcuma KW - Zingiberaceae KW - Zingiberales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-viral properties KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-food/Non-feed Plant Products (SS200) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002085&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enhancement by hydroxyurea of the anti-human immunodeficiency virus type 1 potency of 2′-Β-fluoro-2′,3′-dideoxyadenosine in peripheral blood mononuclear cells. AU - Gao, W. Y. AU - Mitsuya, H. AU - Driscoll, J. S. AU - Johns, D. G. JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1995/// VL - 50 IS - 2 SP - 274 EP - 276 SN - 0006-2952 AD - Gao, W. Y.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A24, Bethesda, MD 20982, USA. N1 - Accession Number: 19962001911. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 69655-05-6, 127-07-1. KW - antiviral agents KW - didanosine KW - HIV infections KW - human diseases KW - hydroxycarbamide KW - inhibitors KW - molecular biology KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dideoxyinosine KW - fluoro-dideoxyadenosine KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - hydroxyurea KW - mononuclear cells KW - peripheral blood KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001911&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence and phylogenetic analyses of human T cell lymphotropic virus type I from a Brazilian woman with adult T cell leukemia: comparison with virus strains from South America and the Caribbean basin. AU - Song, K. J. AU - Nerurkar, V. R. AU - Pereira-Cortez, A. J. AU - Yamamoto, M. AU - Taguchi, H. AU - Miyoshi, I. AU - Yanagihara, R. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1995/// VL - 52 IS - 1 SP - 101 EP - 108 SN - 0002-9637 AD - Song, K. J.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004541. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Tropical Diseases N2 - To clarify the genetic and phylogenetic relationship between an HTLV-I strain isolated from a Brazilian woman with adult T cell leukaemia and viral isolates from elsewhere in South America and from other geographical regions, selected regions of the gag, pol, env, and pX genes were amplified and directly sequenced. The overall sequence similarities between the Brazil-R-1 strain and the Japanese prototype ATK strain were 98.7% based on 1295 nucelotides and 99.1% based on 429 amino acids. Phylogenetic analysis indicated that strain Brazil-R-1 clustered with other Brazilian and South American HTLV-I isolates and was more closely related to Caribbean isolates from Martinique and Guadeloupe than to virus strains from other geographical regions. These data suggest a common source of HTLV-I infection in the Caribbean basin and South America. KW - geographical variation KW - human diseases KW - infections KW - strains KW - Brazil KW - Caribbean KW - South america KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - HTLV-BLV group KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004541&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neurocysticercosis and performance on neuropsychologic tests: a family study in Ecuador. AU - Levav, M. AU - Mirsky, A. F. AU - Cruz, M. E. AU - Cruz, I. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1995/// VL - 53 IS - 5 SP - 552 EP - 557 SN - 0002-9637 AD - Levav, M.: Section on Clinical and Experimental Neuropsychology, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1366, USA. N1 - Accession Number: 19960800931. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - A study of neurocysticercosis (NCC) was conducted in Ecuador in a group of 123 subjects (49 males and 74 females, 9-62 years of age) from a community sample that was part of a larger neuroepidemiological inquiry. A discriminant function procedure was used to select the tests that would be most sensitive at distinguishing between affected and nonaffected individuals. The results suggest that behavioural functions that include aspects of inhibitory control, motor and visual-motor output are impaired in adolescent and adult subjects with NCC. KW - brain KW - clinical aspects KW - diagnosis KW - helminths KW - human diseases KW - metacestodes KW - neurocysticercosis KW - parasites KW - Ecuador KW - South America KW - man KW - Taenia solium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - cerebrum KW - clinical picture KW - host behaviour KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800931&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method. AU - Sinha, R. AU - Rothman, N. AU - Brown, E. D. AU - Salmon, C. P. AU - Knize, M. G. AU - Swanson, C. A. AU - Rossi, S. C. AU - Mark, S. D. AU - Levander, O. A. AU - Felton, J. S. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1995/// VL - 55 IS - 20 SP - 4516 EP - 4519 SN - 0008-5472 AD - Sinha, R.: Epidemiology and Biostatistics Programme, National Cancer Institute, N1H, Rockville Maryland 20892, USA. N1 - Accession Number: 19951414417. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - Heterocyclic aromatic amines (HAAs) are mutagenic and carcinogenic compounds found in meats cooked at high temperatures. Although chicken is consumed in large quantities in the USA, there is little information on its HAA content. The objective of this study was to estimate the 5 predominant HAAa (IQ, MelQ, MeIQx, DiMeIQx and PhIP) in chicken cooked by various methods to different degrees of "doneness". Chicken breasts were pan fried, oven-broiled or grilled/barbecued. Whole chickens were roasted or stewed. Skinless, boneless chicken breasts were cooked to 3 degrees of doneness: just until done, well done or very well done. high levels of PhIP (ranging from 12 to 480 ng/g cooked meat) were found in chicken breasts when pan fried, oven-broiled and grilled/barbecued but not in whole roasted or stewed chicken. PhIP concentration increased in skinless, boneless chicken breast with longer cooking time, higher temperature and greater degree of surface browning. PhIP concentration was also high in chicken breasts cooked with skin and bones. MeIQx and DiMeIQx levels increased with the degree of doneness, whereas IQ and MeIQ were not detectable in any of these chicken samples. Certain cooking methods produce PhIP, a known colon and breast carcinogen in rodents and possibly a human carcinogen, at substantially higher levels in chicken than has been reported previously in red meat. KW - carcinogens KW - chicken meat KW - cooking KW - poultry KW - fowls KW - Gallus gallus KW - Gallus KW - Phasianidae KW - Galliformes KW - birds KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chickens KW - domesticated birds KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414417&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol and pancreatic cancer in blacks and whites in the United States. AU - Silverman, D. T. AU - Brown, L. M. AU - Hoover, R. N. AU - Schiffman, M. AU - Lillemoe, K. D. AU - Schoenberg, J. B. AU - Swanson, G. M. AU - Hayes, R. B. AU - Greenberg, R. S. AU - Benichou, J. AU - Schwartz, A. G. AU - Liff, L. M. AU - Pottern, L. M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1995/// VL - 55 IS - 21 SP - 4899 EP - 4905 SN - 0008-5472 AD - Silverman, D. T.: Epidemiology & Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951414940. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition N2 - A population-based, case-control study of pancreatic cancer based on direct interviews with 307 white and 179 black incident cases and 1164 white and 945 black population controls was conducted in 3 areas of the USA to examine the role alcohol drinking plays as a risk factor for pancreatic cancer and to estimate the extent to which it may explain the higher incidence of pancreatic cancer in blacks compared to whites. The findings indicate that alcohol drinking at the levels typically consumed by the general population of the USA is probably not a risk factor for pancreatic cancer. The data suggest, however, that heavy alcohol drinking may be related to pancreatic cancer risk. Among men, blacks and whites who drank at least 57 drinks/week had odds ratios (ORs) of 2.2 (95% confidence interval (CI) = 0.9-5.6) and 1.4 (95% CI = 0.6-3.2), respectively. Among women, blacks who drank 8 to <21 drinks/week had an OR of 1.8 (95% CI = 0.8-4.0) and those who drank at least 21 drinks/week had an OR of 2.5 (95% CI = 1.02-5.9), but whites with the same levels of alcohol intake experienced no increased risk. Compared to whites, blacks had higher ORs associated with heavy alcohol drinking (≥57 drinks/week) in men (P=0.04) and with moderate-to-heavy drinking (≥8 drinks/week) in women (P=0.03). KW - alcoholic beverages KW - neoplasms KW - pancreas KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414940&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate. AU - Lucia, M. S. AU - Anzano, M. A. AU - Slayter, M. V. AU - Anver, M. R. AU - Green, D. M. AU - Shrader, M. W. AU - Logsdon, D. L. AU - Driver, C. L. AU - Brown, C. C. AU - Peer, C. W. AU - Roberts, A. B. AU - Sporn, M. B. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1995/// VL - 55 IS - 23 SP - 5621 EP - 5627 SN - 0008-5472 AD - Lucia, M. S.: Laboratory of Chemoprevention and Biometry Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19961402625. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition N2 - The ability of dietary N-(4-hydroxyphenyl)retinamide; 1α,25-dihydroxy-16-ene-23-yne-26,27-hexafluorochlolecalciferol (Ro24-5531) and tamoxifen to inhibit the development of androgen-promoted carcinomas of the accessory sex organs of male Lobund-Wistar rats was investigated. Invasive carcinomas of the seminal vesicle (SV) and anterior prostate (AP) were induced in Lobund-Wistar rats with 3 combinations of initiator (N-nitroso-N-methylurea (NMU)) and promoter (testosterone propionate (TP)): high-dose NMU (30 mg/kg + high-dose TP (20 mg via implant every 2 months)); high-dose NMU + low-dose TP (10 mg implanted every 2 months); or low-dose NMU (15 mg/kg) + low-dose TP. During the period of TP administration, rats were fed on a diet supplemented with N-(4-hydroxyphenyl)retinamide (1 or 2 nmol/kg diet), Ro24-5531 (1.25 or 2.5 nmol/kg diet), tamoxifen (0.5 or 5 mg/kg diet) or vehicle alone. After killing at 8.5 or 11 months, the prostate-seminal vesicle complex from each rat was processed in toto and histologically staged as to the extent of tumour involvement. In rats given low-dose TP, all 3 agents were significantly effective at reducing the incidence of invasive carcinomas of the SV and, to a lesser degree, the AP. Of the 3 agents, tamoxifen given in high dose (5 mg/kg) had the strongest activity, reducing the occurrence of invasive SV carcinomas from 72-83% in controls to 6% (P=0.0001) and the occurrence of invasive AP carcinomas from 50-72% to 18-22% (P<0.05). KW - analogues KW - antineoplastic agents KW - vitamin D KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - cytotoxic agents KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402625&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel phorbol ester from Excoecaria agallocha. AU - Erickson, K. L. AU - Beutler, J. A. AU - Cardellina, J. H., II AU - McMahon, J. B. AU - Newman, D. J. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1995/// VL - 58 IS - 5 SP - 769 EP - 772 SN - 0163-3864 AD - Erickson, K. L.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, NCI-FCRDC, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950313448. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - The leaves and latex of E. agallocha are used as a source of dart-arrow and/or fish poison, and are also used in herbal formulations. In Pakistan, the latex is used as an abortifacient, and to treat rheumatism, leprosy and paralysis. A novel phorbol ester, 12-deoxyphorbol 13-(3E,5E-decadienoate), was isolated from the bark, leaves and stems of E. agallocha (collected from northwest Australia). Its structure was determined by spectral means. 12-Deoxyphorbol 13-(3E,5E-decadienoate) inhibited the replication of HIV-1 [human immunodeficiency virus type 1] in vitro (IC50 value of 6 nM). The phorbol ester was also a potent displacer of [³H]-phorbol dibutyrate from rat brain membranes (IC50 of 17 nM). KW - antiviral properties KW - bark KW - brain KW - chemical structure KW - diterpenoids KW - esters KW - foliage KW - forest trees KW - human immunodeficiency viruses KW - leaves KW - mangroves KW - medicinal plants KW - medicinal properties KW - membranes KW - pharmacology KW - plant composition KW - poisonous plants KW - stems KW - trees KW - woody plants KW - Australia KW - animals KW - Euphorbiaceae KW - Excoecaria agallocha KW - plants KW - rats KW - eukaryotes KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Excoecaria KW - Euphorbiaceae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - anti-viral properties KW - cerebrum KW - chemical constituents of plants KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - toxic plants KW - Plant Composition (FF040) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Silviculture and Forest Management (KK110) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950313448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The pseudocalanolides: structure revision of calanolides C and D. AU - McKee, T. C. AU - Cardellina, J. H., II AU - Dreyer, G. B. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1995/// VL - 58 IS - 6 SP - 916 EP - 920 SN - 0163-3864 AD - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950614177. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 9068-38-6. Subject Subsets: Horticultural Science; Forestry; Forest Products; Aromatic & Medicinal Plants N2 - Calanolides, coumarin compounds in a novel class of HIV-1 reverse transcriptase inhibitors, were isolated recently from a tropical rain forest tree, Calophyllum lanigerum var. austrocoriaceum. NMR spectra of synthetic structures corresponding to those initially reported for natural compounds calanolide C and calanolide D showed some subtle differences from those of the natural products. Further analysis has resulted in revision of the structures of the natural compounds, now renamed pseudocalanolides C and D. KW - chemical structure KW - coumarins KW - enzyme inhibitors KW - forest trees KW - forests KW - human immunodeficiency viruses KW - medicinal plants KW - medicinal properties KW - plant composition KW - rain forests KW - reverse transcriptase KW - trees KW - woody plants KW - Calophyllum KW - Clusiaceae KW - plants KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Calophyllum KW - Calophyllum lanigerum KW - chemical constituents of plants KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - pseudocalanolides KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950614177&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A reinvestigation of Maprounea triterpenes. AU - Beutler, J. A. AU - Kashman, Y. AU - Tischler, M. AU - Cardellina, J. H., II AU - Gray, G. N. AU - Currens, M. J. AU - Wall, M. E. AU - Wani, M. C. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1995/// VL - 58 IS - 7 SP - 1039 EP - 1046 SN - 0163-3864 AD - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19950315464. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in M. africana (collected from Central African Republic) and M. membranacea (collected from Cameroon) were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were isolated, 2 from M. africana and 3 from M. membranacea. Their structures were elucidated from spectral data. KW - chemical structure KW - medicinal plants KW - medicinal properties KW - plant composition KW - triterpenoids KW - Cameroon KW - Central African Republic KW - Euphorbiaceae KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Euphorbiaceae KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - Least Developed Countries KW - chemical constituents of plants KW - drug plants KW - Maprounea KW - Maprounea africana KW - Maprounea membranacea KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950315464&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula. AU - Erickson, K. L. AU - Beutler, J. A. AU - Gray, G. N. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1995/// VL - 58 IS - 12 SP - 1848 EP - 1860 SN - 0163-3864 AD - Erickson, K. L.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19960305290. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Seven new sesquiterpenes, majapolenes A and B, majapolone and majapols A-D, were isolated from a Philippine collection of L. majuscula. With the exception of majapolene B, all compounds were isolated as inseparable diastereomeric mixtures. Their structures were elucidated from spectral data. Majapolene A, a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of L. caraibica. KW - chemical structure KW - cytotoxicity KW - plant composition KW - sesquiterpenes KW - sesquiterpenoids KW - Philippines KW - algae KW - Ceramiales KW - Rhodomelaceae KW - Rhodophyta KW - plants KW - aquatic plants KW - aquatic organisms KW - eukaryotes KW - algae KW - seaweeds KW - Rhodophyta KW - Ceramiales KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - chemical constituents of plants KW - Laurencia KW - Laurencia caraibica KW - Laurencia majuscula KW - red algae KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960305290&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of nitric oxide in parasitic infections. AU - James, S. L. JO - Microbiological Reviews JF - Microbiological Reviews Y1 - 1995/// VL - 59 IS - 4 SP - 533 EP - 547 SN - 0146-0749 AD - James, S. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19950811311. Publication Type: Journal Article. Language: English. Number of References: 204 ref. Registry Number: 10102-43-9. Subject Subsets: Helminthology; Protozoology N2 - This review covers: nitric oxide synthesis; nitric oxide action; regulation of NO production (cytokine signals enhancing NO production, signals down-regulating NO production); antiparasitic effects of NO (macrophage activity against parasite targets- schistosomiasis, leishmaniasis, toxoplasmosis, and trypanosomiasis, the unresolved case of human macrophages, activity of other cell types against parasite targets- endothelial cells, and hepatocytes); immune evasion mechanisms against NO (Toxoplasma stage conversion, schistosome metabolic transitions); other effects of NO in parasitic diseases (immunosuppression, vascular function, cancer, cerebral malaria). KW - helminths KW - nitric oxide KW - parasites KW - reviews KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950811311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Smoking and cancer mortality among US veterans: a 26-year follow-up. AU - McLaughlin, J. K. AU - Hrubec, Z. AU - Blot, W. J. AU - Fraumeni, J. F., Jr. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 60 IS - 2 SP - 190 EP - 193 SN - 0020-7136 AD - McLaughlin, J. K.: National Cancer Institute, 6130 Executive Blvd, Room 543, Rockville, MD 20852, USA. N1 - Accession Number: 19962001424. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health N2 - A 26-year follow-up of 248 046 veterans in the USA evaluating the risks of cigarette smoking revealed strong dose response effects between smoking and total cancer and a large number of cancer sites. Over 50% of cancer deaths among current smokers and 23% of cancer deaths among former smokers were attributable to cigarette smoking. KW - mortality KW - neoplasms KW - risk factors KW - tobacco smoking KW - toxicology KW - veterans KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - death rate KW - United States of America KW - war veterans KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001424&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prostate cancer risk in US blacks and whites with a family history of cancer. AU - Hayes, R. B. AU - Liff, J. M. AU - Pottern, L. M. AU - Greenberg, R. S. AU - Schoenberg, J. B. AU - Schwartz, A. G. AU - Swanson, G. M. AU - Silverman, D. T. AU - Morris Brown, L. AU - Hoover, R. N. AU - Fraumeni, J. F., Jr. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 60 IS - 3 SP - 361 EP - 364 SN - 0020-7136 AD - Hayes, R. B.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001421. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health N2 - Prostate cancer occurs more frequently in blacks than whites in the USA. A population-based case-control study which investigated the association with family history of cancer was carried out among 981 men (479 black, 502 white) with pathologically confirmed prostate cancer, diagnosed between August 1, 1986, and April 30, 1989, and 1315 controls (594 black, 721 white). Study subjects, aged 40-79, resided in Atlanta (Georgia), Detroit (Michigan), and 10 counties in New Jersey. Prostate cancer risk was significantly elevated among those who reported a history of prostate cancer in first-degree relatives (OR = 3.2; 95% CI: 2.0-5.0), with blacks and whites having similarly elevated risks. These risks were unchanged by statistical adjustment for job-related socio-economic status, education, income and marital status. Overall, the ORs associated with history of prostate cancer in fathers and brothers were 2.5 (95% CI: 1.5-4.2) and 5.3 (95% CI: 2.3-12.5), respectively. Younger and older subjects showed consistently elevated risks associated with a family history of prostate cancer. Only small non-significant excesses of prostate cancer risk were associated with a family history of breast, colorectal, or other cancer. While familial occurrence is a key risk factor for prostate cancer and likely to be genetically based, the similar familial risks among blacks and whites suggest that the ethnic disparity in incidence is influenced by environmental factors. KW - blacks KW - epidemiology KW - ethnic groups KW - familial incidence KW - human diseases KW - neoplasms KW - prostate KW - prostate cancer KW - risk factors KW - Georgia KW - Michigan KW - New Jersey KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southeastern States of USA KW - East North Central States of USA KW - North Central States of USA KW - Lake States of USA KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001421&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica. AU - Strickler, H. D. AU - Rattray, C. AU - Escoffery, C. AU - Manns, A. AU - Schiffman, M. H. AU - Brown, C. AU - Cranston, B. AU - Hanchard, B. AU - Palefsky, J. M. AU - Blattner, W. A. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 61 IS - 1 SP - 23 EP - 26 SN - 0020-7136 AD - Strickler, H. D.: Viral and Environmental Epidemiology Branches, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962002660. Publication Type: Journal Article. Language: English. Number of References: 22 ref. KW - biopsy KW - cervical cancer KW - concurrent infections KW - HTLV infections KW - human diseases KW - neoplasms KW - polymerase chain reaction KW - risk factors KW - sexual behaviour KW - women KW - Jamaica KW - Deltaretrovirus KW - human papillomaviruses KW - human t-cell lymphotropic virus type i KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Papillomaviridae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - cancers KW - colposcopy KW - HTLV-BLV group KW - human papillomavirus KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Pap smear KW - Papovaviridae KW - PCR KW - sexual behavior KW - sexual practices KW - sexuality KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002660&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Undernutrition among Bedouin Arab children: a follow-up of the Bedouin Infant Feeding Study. AU - Forman, M. R. AU - Hundt, G. L. AU - Berendes, H. W. AU - Abu-Saad, K. AU - Zangwill, L. AU - Chang, D. AU - Bellmaker, I. AU - Abu-Saad, I. AU - Graubard, B. I. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 61 IS - 3 SP - 495 EP - 500 SN - 0002-9165 AD - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19951404448. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition N2 - After 10 years of urban settlement, 680 Bedouin Arab children in Israel, who had had anthropometric assessment from birth (1981-1982) through early childhood, were reassessed in 1991-1992 to compare the rates of stunting in early and later childhood as well as to describe the factors influencing current height-for-age. Stunting had decreased from 32.7% at 18 months to 7.2% at 10 years in the 1981 birth cohort and decreased from 17.5% at 9 months to 8.2% at 9 years in the 1982 birth cohort. Based on a multiple-linear-regression analysis, height in early childhood and maternal height were significantly and positively associated with current mean height-for-age in both cohorts. In the 1982 cohort, socioeconomic status in early childhood was positively and significantly associated with current mean height-for-age. Thus, conditions that were present in early childhood had the largest influence on current height. In 1992, 10 and 6% of the infant siblings of the 1981 and 1982 cohorts, respectively, were stunted cohorts. Therefore, the high rates of early childhood stunting in 1981-1982 appeared to be a birth cohort-specific phenomenon. KW - children KW - ethnic groups KW - growth KW - growth retardation KW - infant feeding KW - infants KW - nutritional state KW - social change KW - undernutrition KW - Israel KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - Mediterranean Region KW - Middle East KW - West Asia KW - Asia KW - nutritional status KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thermic effect of food in humans: methods and results from use of a respiratory chamber. AU - Tataranni, P. A. AU - Larson, D. E. AU - Snitker, S. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 61 IS - 5 SP - 1013 EP - 1019 SN - 0002-9165 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 19951406877. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - During the past 2 decades, many investigators have estimated the thermic effect of food (TEF) in man and have speculated on its role in the development of obesity. Ways of computing TEF from daily energy expenditure estimations in a respiratory chamber were compared, the determinants of TEF evaluated and the relation between TEF and change in body weight was investigated. In 471 subjects, TEF was 1697±857 kJ/d (χ±s.d.), i.e., 18±9% of energy intake. In 114 subjects studied more than once, intraindividual TEF variability was very high (CV=48%). TEF correlated positively with the level of spontaneous physical activity (SPA) and negatively with fasting plasma glucose and insulin concentrations. TEF corelated inversely with age (men only) and body weight, percent body fat and waist-to-hip ratio (women only). The level of SPA and fasting plasma glucose concentration were the only significant determinants of TEF, explaining 15% of its variance. In 137 subjects in whom body weight was estimated ≥ 6 months after TEF estimation (mean follow-up duration of 2.9±1.7 years) a low TEF was not predictive of body weight gain. It is concluded that, despite the low reproducibility of TEF from use of a respiratory chamber, data in a large number of subjects is increased by higher SPAs and that insulin resistance is associated with a low TEF. More important, longitudinal data indicate that the variability in TEF is not associated with changes in body weight. KW - food intake KW - heat production KW - men KW - methodology KW - obesity KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorigenesis KW - fatness KW - methods KW - thermogenesis KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406877&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary behavior change: the challenge of recasting the role of fruit and vegetables in the American diet. AU - Heimendinger, J. AU - Duyn, M. A. S. van JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 61 IS - 6(S) SP - 1397S EP - 1401S SN - 0002-9165 AD - Heimendinger, J.: National Cancer Institute, National Institutes of Health, Division of Cancer Prevention and Control, 9000 Rockville Pike, EPN 330, Bethesda, MD 20892, USA. N1 - Accession Number: 19951408559. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - Trends in intake of fruits and vegetables in the USA are examined using a combination of consumption and marketing data. A brief overview of the current social marketing programme, 5 a Day for Better Health is also provided. It is described how theories of behaviour change have been applied to the development of this programme. Finally, using the Mediterranean diet as a model system, a new strategy for using the sensory qualities of fruit and vegetables, in combination with a health message, to help encourage Americans to increase consumption of these foods is proposed. KW - behaviour KW - diet studies KW - feeding behaviour KW - fruit KW - intake KW - nutrition education KW - nutrition programmes KW - vegetables KW - Mediterranean region KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - behavior KW - feeding behavior KW - feeding programmes KW - feeding programs KW - food programs KW - Mediterranean countries KW - nutrition programs KW - United States of America KW - vegetable crops KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408559&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analgesics and cancers of the renal pelvis and ureter. AU - Linet, M. S. AU - Chow WongHo AU - McLaughlin, J. K. AU - Wacholder, S. AU - Yu, M. C. AU - Schoenberg, J. B. AU - Lynch, C. AU - Fraumeni, J. F., Jr. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 62 IS - 1 SP - 15 EP - 18 SN - 0020-7136 AD - Linet, M. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962005038. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health N2 - To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the USA (New Jersey, Iowa, California). Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the non-prescription and prescription analgesics evaluated or among regular users of phenacetin, acetaminophen or aspirin. Neither cumulative lifetime ingestion nor duration of regular use of these 3 drugs, whether alone or in combination, was associated with significantly increased risk of RPU cancer, although a slight excess was observed among long-term users of acetaminophen. Risk was not increased among persons reporting highest cumulative dose and/or longest duration of phenacetin use. Although this study of RPU cancer is the largest to date, it was nonetheless limited by the small number of regular analgesic users and the relatively low response rates. Because of the relatively recent onset of widespread use of acetaminophen, its pharmacological similarity to phenacetin, a known urothelial carcinogen, and the elevation in risk seen in long-term users, further surveillance of this analgesic is believed to be warranted. KW - analgesics KW - human diseases KW - kidneys KW - neoplasms KW - risk factors KW - ureter KW - urinary tract KW - California KW - Iowa KW - New Jersey KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Corn Belt States of USA KW - North Central States of USA KW - West North Central States of USA KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - cancer sites KW - cancers KW - pain killers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005038&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of alcohol consumption on plasma carotenoid concentrations in premenopausal women: a controlled dietary study. AU - Forman, M. R. AU - Beecher, G. R. AU - Lanza, E. AU - Reichman, M. E. AU - Graubard, B. I. AU - Campbell, W. S. AU - Marr, T. AU - Yong, L. C. AU - Judd, J. T. AU - Taylor, P. R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 1 SP - 131 EP - 135 SN - 0002-9165 AD - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19951409555. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - This 6-month controlled dietary study compared the effect of alcohol 30 g/day for 3 menstrual cycles with 3 alcohol-free cycles on plasma carotenoid concentrations in 18 nonsmoking, premenopausal women (21 to 39 years old). Participants were randomly allocated within a crossover design to either phase and consumed total carotenoids about 6 mg/day under isoenergetic conditions. Blood was drawn during the third menstrual cycle of each alcohol phase. After adjustment for the mean daily specific carotenoid and energy intakes for each alcohol phase, the paired differences in mean plasma α- and β-carotene concentrations were higher by 19% (P=0.027) and 13% (P=0.034), respectively, during the alcohol-intake phase of the study. The paired difference in mean plasma lutein/zeaxanthin concentration was lower by 17% (P=0.031) when the participants consumed alcohol than when they did not. This is the first reported study in women to document the independent effect of alcohol on plasma carotenoid concentrations without the potential interaction of smoking under controlled dietary conditions. KW - alcoholic beverages KW - blood KW - carotenoids KW - intake KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - tetraterpenoids KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409555&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoic acid and methotrexate specifically increase PHA-E lectin binding to a 67-kDa glycoprotein in LA-N-1 human neuroblastoma cells. AU - Ross, S. A. AU - Jones, C. S. AU - Luca, L. M. de JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 62 IS - 3 SP - 303 EP - 308 SN - 0020-7136 AD - Ross, S. A.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bldg. 37, Rm. 3A17 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19961404454. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 59-05-2, 302-79-4. Subject Subsets: Human Nutrition N2 - Retinoic acid (RA) decreased growth and increased morphologic differentiation of human neuroblastoma LA-N-1 cells. These phenomena correlated with a specific enhancement of PHA-E lectin binding to a 67-kDa glycoprotein (gp67). Gp67 was susceptible to N-glycanase and displayed bovine serum albumin (BSA) binding by affinity chromatography analysis. The chemotherapeutic agent methotrexate (MTX) also reduced growth and induced differentiation of LA-N-1 cells. In addition, the cells responded to MTX as well as to doxorubicin by a marked increase in PHA-E binding to gp67. It is concluded that reduced growth and induction of morphological differentiation of LA-N-1 cells correlated with increased binding of PHA-E to gp67. KW - binding KW - cell cultures KW - cell growth KW - cell membranes KW - glycoproteins KW - lectins KW - methotrexate KW - neoplasms KW - receptors KW - retinoic acid KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - amethopterin KW - cancers KW - cell elongation KW - tretinoin KW - vitamin A acid KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404454&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cinnamic acid: a natural product with potential use in cancer intervention. AU - Liu Lei AU - Hudgins, W. R. AU - Shack, S. AU - Yin MuQuan AU - Samid, D. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1995/// VL - 62 IS - 3 SP - 345 EP - 350 SN - 0020-7136 AD - Liu Lei: Clinical Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, Building 10, Room 12C103, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19960305465. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 621-82-9. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Human Nutrition N2 - Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, has a long history of human use as a component of plant-derived scents and flavourings. In this study, cinnamic acid was shown to induce cytostasis and a reversal of malignant properties of human tumour cells in vitro. The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. Using melanoma cells as a model, cinnamic acid was found to induce cell differentiation, as evidenced by morphological changes and increased melanin production. Moreover, treated cells had reduced invasive capacity associated with modulation of expression of genes implicated in tumour metastasis (collagenase type IV, and tissue inhibitor metalloproteinase 2) and immunogenicity (HLA-A3, class-1 major histocompatibility antigen). Further molecular analysis indicated that the anti-tumour activity of cinnamic acid may be due in part to the inhibition of protein isoprenylation known to block mitogenic signal transduction. The results presented here identify cinnamic acid as a new member of the aromatic fatty acid class of differentiation-inducers with potential use in cancer intervention. KW - antineoplastic properties KW - cell differentiation KW - cell lines KW - cinnamic acid KW - fatty acids KW - gene expression KW - in vitro KW - metastasis KW - modulation KW - natural products KW - neoplasms KW - phenylpropanoids KW - plant composition KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anti-neoplastic properties KW - cancers KW - chemical constituents of plants KW - cytodifferentiation KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960305465&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of dual-energy X-ray absorptiometry in obese individuals. AU - Tataranni, P. A. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 4 SP - 730 EP - 734 SN - 0002-9165 AD - Tataranni, P. A.: Department of Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 19951413477. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - Body composition of 183 obese subjects with a wide range of body sizes (body mass index = 17.7-52.5 kg/m²) was assessed using dual-energy X-ray absorptiometry (DXA). Results from both sides of the body were compared to test the hypothesis that body composition is symmetrical. Data obtained by DXA were compared with those obtained by hydrodensitometry. Also the hypothesis that body composition of 1 side of the body (by DXA) accurately predicts whole body composition (by hydrodensitometry) was investigated. This latter hypothesis was validated. KW - body composition KW - estimation KW - methodology KW - obesity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - methods KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413477&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy metabolism in weight-stable postobese individuals. AU - Larson, D. E. AU - Ferraro, R. T. AU - Robertson, D. S. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 4 SP - 735 EP - 739 SN - 0002-9165 AD - Larson, D. E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19951413498. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - A low metabolic rate for a given body size and body composition and a low ratio of fat to carbohydrate oxidation predict body weight gain. Such metabolic traits could also explain, in part, the propensity of previously obese (post-obese) individuals to regain weight after dieting. 11 post-obese adults 43±13 years old, weighing 80.6±10.2 kg with 30±7% body fat (mean±s.d.); who lost 57±38 kg (23-139 kg) over 14±12 months (6-48 months) on various diet programmes and had maintained this weight loss for ≥ 2 months (2-72 months; 21±27 months), were studied. After ≥ 2 days of a weight-maintenance diet in a metabolic ward, 24-h energy expenditure and ratio of fat to carbohydrate oxidation were estimated in a respiratory chamber. Compared with a control group (n=110) with similar physical characteristics (43±14 years old, weighing 79.5±11.4 kg with 30±12% body fat), post-obese individuals had similar energy expenditures adjusted for fat-free mass, fat mass, age and sex, but higher respiratory quotients over 24 h (0.883±0.026 compared with 0.863±0.024, P<0.01) and during sleep, 10 h after the last meal (0.894±0.063 compared with 0.845±0.055). Results suggest that post-obese individuals have low rates of fat oxidation that may explain their propensity to regain weight. Therefore, obesity treatment and/or prevention should be aimed at reducing dietary fat and increasing fat oxidation (possibly by exercise) to prevent increases in body fat stores. KW - adults KW - body weight KW - energy KW - energy metabolism KW - obesity KW - weight reduction KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413498&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol and energy intake. AU - Lands, W. E. M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 5 SUPP SP - 1101S EP - 1106S SN - 0002-9165 AD - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, Willco Building, Suite 402, 6000 Executive Boulevard, MSC 7003, Bethesda, MD 20892-7003, USA. N1 - Accession Number: 19951414602. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 55 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition KW - alcoholic beverages KW - energy KW - energy intake KW - ethanol KW - intake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Advances in human energy metabolism: balancing energy requirements and energy intake KW - ethyl alcohol KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414602&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determination of optimal vitamin C requirements in humans. AU - Levine, M. AU - Dhariwal, K. R. AU - Welch, R. W. AU - Wang, Y. H. AU - Park, J. B. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 6 (SUP) SP - 1347S EP - 1356S SN - 0002-9165 AD - Levine, M.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-0850, USA. N1 - Accession Number: 19961400398. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 137 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition KW - ascorbic acid KW - nutrient requirements KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Antioxidant vitamins and beta-carotene in disease prevention KW - dietary standards KW - food requirements KW - nutritional requirements KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400398&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of nutrition intervention on intermediate endpoints in esophageal and gastric carcinogenesis. AU - Taylor, P. R. AU - Wang GuoQing AU - Dawsey, S. M. AU - Guo, W. AU - Mark, S. D. AU - Li JunYao AU - Blot, W. J. AU - Li Bing JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 6 (SUP) SP - 1420S EP - 1423S SN - 0002-9165 AD - Taylor, P. R.: National Cancer Institute, Executive Plaza North, Room 211, Bethesda, MD 20896, USA. N1 - Accession Number: 19961400409. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition KW - carcinogenesis KW - minerals KW - oesophagus KW - stomach KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Antioxidant vitamins and beta-carotene in disease prevention KW - esophagus KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400409&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of α-tocopherol and β-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention study. AU - Albanes, D. AU - Heinonen, O. P. AU - Huttunen, J. K. AU - Taylor, P. R. AU - Virtamo, J. AU - Edwards, B. K. AU - Haapakoski, J. AU - Rautalahti, M. AU - Hartman, A. M. AU - Palmgren, J. AU - Greenwald, P. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1995/// VL - 62 IS - 6 (SUP) SP - 1427S EP - 1430S SN - 0002-9165 AD - Albanes, D.: National Cancer Institute, 6130 Executive Plaza North, MSC 7326 Room 211, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19961400411. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 28 ref. Registry Number: 59-02-9, 7235-40-7. Subject Subsets: Human Nutrition KW - alpha-tocopherol KW - antioxidants KW - beta-carotene KW - neoplasms KW - prevention KW - supplements KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Antioxidant vitamins and beta-carotene in disease prevention KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400411&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice. AU - Eltoum, I. A. AU - Wynn, T. A. AU - Poindexter, R. W. AU - Finkelman, F. D. AU - Lewis, F. A. AU - Sher, A. AU - Cheever, A. W. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1995/// VL - 63 IS - 7 SP - 2532 EP - 2536 SN - 0019-9567 AD - Eltoum, I. A.: Section on Host-Parasite Relations, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20890, USA. N1 - Accession Number: 19960803635. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 207137-56-2. Subject Subsets: Helminthology N2 - A number of anticytokine antibody treatments have been shown to have a remarkable effect in modulating granulomas around intravenously injected Schistosoma mansoni eggs in the mouse model but little effect on the size of hepatic granulomas around eggs laid during experimental infections in mice. To examine this discrepancy, the effects of anticytokine antibodies on liver and lung granulomas around injected eggs and around eggs laid during infection in both locations were investigated. Anti-interleukin (IL)-4 treatment by neutralizing MAb greatly reduced the volume of granulomas around eggs injected into the liver via the portal vein and around eggs injected into the lungs via the tail vein. In contrast, granulomas around eggs laid by worms in either the liver or the lungs during the course of infection were not significantly decreased by anti-IL-4 treatment. Thus, site is not important for the disparate effects of anti-IL-4 in granuloma formation around injected versus laid eggs. This effect was seen in naive and sensitized animals and is most probably due to differences in the quality of injected eggs versus those laid in situ. KW - disease models KW - experimental infections KW - granuloma KW - helminth ova KW - helminths KW - immunology KW - immunopathology KW - interleukin 4 KW - laboratory animals KW - liver KW - lungs KW - monoclonal antibodies KW - parasites KW - pathology KW - schistosomiasis KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803635&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. AU - Stevenson, B. AU - Schwan, T. G. AU - Rosa, P. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1995/// VL - 63 IS - 11 SP - 4535 EP - 4539 SN - 0019-9567 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19960503530. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Previous studies have demonstrated that B. burgdorferi in the midguts of infected ticks shows increased expression of the antigenic outer surface protein OspC after the ticks have ingested a blood meal. This differential expression is at least partly due to a change in temperature, as an increase in OspC levels is also observed when cultures are shifted from 23 to 35°C. Immunoblotting of bacterial lysates with sera from infected mice indicated that the levels of several additional antigens were also increased in bacterial cultures shifted to 35°C; one antigen was identified as OspE. The authors also observed differential expression of OspF, which has been proposed to be coexpressed in an operon with the gene encoding OspE. KW - antigens KW - gene expression KW - laboratory animals KW - Lyme disease KW - proteins KW - temperature KW - Borrelia burgdorferi KW - mice KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - bacterium KW - immunogens KW - lyme borreliosis KW - outer surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503530&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic map of eight microsatellite markers comprising two linkage groups on rat chromosome 6. AU - Du, Y. AU - Remmers, E. F. AU - Zha, H. AU - Goldmuntz, E. A. AU - Mathern, P. AU - Crofford, L. J. AU - Szpirer, J. AU - Szpirer, C. AU - Wilder, R. L. JO - Cytogenetics and Cell Genetics JF - Cytogenetics and Cell Genetics Y1 - 1995/// VL - 68 IS - 1/2 SP - 107 EP - 111 SN - 0301-0171 AD - Du, Y.: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950100890. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9001-15-4, 9007-49-2, 9026-43-1. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - Five genes and 3 anonymous DNA loci were mapped to rat chromosome 6 by genetic linkage and somatic cell hybrid analyses. The 8 loci were all identified by PCR-based microsatellite polymorphism analysis and were characterized in 40 F2 intercross progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rats for segregation analysis. These markers formed 2 linkage groups spanning 58.1 and 4.0 cM. The 1st linkage group is comprised of 2 anonymous DNA loci and 4 genes with the following map order and distances; D6Cep8 (previously D3)-17.9 cM-D6Arb309-2.5 cM-Vsnl1 (neural visinin-like protein)-20.4 cM-Prkar2b (type IIβ regulatory subunit of cAMP-dependent protein kinase)-8.8 cM-Fkhl1 (forkhead-like transcription factor BF-1)-8.5 cM-Rnulc(18-3A U1 RNA). The 2nd linkage group is comprised of 1 gene, Ckb (creatine kinase, brain) and 1 anonymous DNA locus, D6Arb54, separated by 4.0 cM. For each marker, 2 to 8 alleles were detected in a panel of 16 inbred rat strains (ACI/N, BN/SsN, BUF/N, DA/Bk1, F344/N, LER/N, LEW/N, LOU/MN, MNR/N, MR/N, SHR/N, SR/Jr, SS/Jr, WBB1/N, WBB2/N, and WKY/N). Comparative mapping information indicated that rat chromosome 6 exhibits syntenic conservation with mouse chromosome 12. Homologues of the rat chromosome 6 loci were identified on human chromosomes 2, 7 and 14. KW - biotechnology KW - brain KW - chromosomes KW - creatine kinase KW - DNA KW - gene mapping KW - linkage groups KW - markers KW - microsatellites KW - protein kinase KW - transcription factors KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - creatine phosphokinase KW - deoxyribonucleic acid KW - minisatellites KW - No. 6 KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) KW - Human Physiology and Biochemistry (VV050) KW - Laboratory Animal Science (LL040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950100890&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis. AU - Vaidya, A. B. AU - Muratova, O. AU - Guinet, F. AU - Keister, D. AU - Wellems, T. E. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1995/// VL - 69 IS - 1 SP - 65 EP - 71 SN - 0166-6851 AD - Vaidya, A. B.: Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19950805782. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - A Plasmodium falciparum clone, Dd2, differentiates into normal-appearing gametocytes, yet poorly infects mosquitoes. The Dd2 clone, however, effectively cross-fertilized HB3, a Central American P. falciparum clone, and yielded several independent recombinant progeny. 11 HB3 X Dd2 progeny were examined for their ability to infect mosquitoes (Anopheles freeborni) and to differentiate into male gametes. The analyses indicated that the poor mosquito-infectivity of the Dd2 clone results from a defect in male gametogenesis. This defect was inherited as a single locus in the independent recombinant progeny of HB3 X Dd2. Comparison with a restriction fragment length polymorphism map of the HB3 X Dd2 cross indicated that the defective phenotype of Dd2 maps to a locus on P. falciparum chromosome 12. This genetic locus may contain determinants that play a crucial role in male gametogenesis by P. falciparum. KW - chromosomes KW - Disease vectors KW - gametogenesis KW - genetics KW - human diseases KW - infectivity KW - parasites KW - Anopheles freeborni KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unique insertion sequence and pattern of CD4 expression in variants selected with immunotoxins from human immunodeficiency virus type 1-infected T cells. AU - Fang, H. AU - Pincus, S. H. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 1 SP - 75 EP - 81 SN - 0022-538X AD - Fang, H.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth St., Hamilton, MT 59840, USA. N1 - Accession Number: 19952010306. Publication Type: Journal Article. Language: English. Number of References: 26 ref. KW - cd4 antigens KW - human diseases KW - human immunodeficiency viruses KW - infectivity KW - mutants KW - T lymphocytes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - human immunodeficiency virus KW - immunotoxins KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy. AU - Lisziewicz, J. AU - Sun, D. AU - Trapnell, B. AU - Thomson, M. AU - Chang, H. K. AU - Ensoli, B. AU - Peng, B. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 1 SP - 206 EP - 212 SN - 0022-538X AD - Lisziewicz, J.: Laboratory of Tumour Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, 37 Convent Dr. MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952010288. Publication Type: Journal Article. Language: English. Number of References: 36 ref. KW - gene therapy KW - genetic regulation KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - tat gene KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rabies virus replication in primary murine bone macrophages and in human and murine macrophage-like cell lines: implications for viral persistence. AU - Ray, N. B. AU - Ewalt, L. C. AU - Lodmell, D. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 2 SP - 764 EP - 772 SN - 0022-538X AD - Ray, N. B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19952203306. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - To determine whether rabies viruses replicate in macrophage-like cells, several human and murine macrophage-like cell lines, and primary cultures of murine bone marrow macrophages, were incubated with the Evelyn-Rokitnicki-Abelseth (ERA) virus and several different street rabies viruses (SRV). ERA rabies virus replicated well in human monocytic U937 and THP-1 cells and murine macrophage IC-21 cells, and in primary cultures of murine macrophages. Very little replication was detected in murine monocytic WEHI-3BD- and PU5-1R cells and ERA virus did nor replicate in murine monocytic P388D1 or J774A.1 cells. A tissue culture-adapted SRV of bat origin also replicated in IC-21 and U937 cells. Non-tissue culture-adapted SRV isolated from different animal species, particularly bats, replicated very little in U937, THP-1, IC-21 cells and primary murine bone marrow macrophages. To determine whether rabies virus replication depends on the state of differentiation of the macrophage-like cells, human promyelocytic HL-60 were differentiated with 12-O-tetradeconylphorbol-13-acetate (TPA). ERA rabies virus replicated in the differentiated HL-60 but not in undifferentiated HL-60 cells. Persistent infections were established in macrophage-like U937 cells with ERA rabies virus and SRV, and infectious SRV was isolated from adherent bone marrow cells of mice that had been infected 96 days earlier. Virus harvest from persistently infected U937 and the adherent bone marrow cells had specifically adapted to each cell. This specificity was shown by the inability of the viruses to infect macrophages other than U937 and primary bone marrow macrophages, respectively. Virus titres of the persistently infected U937 cells fluctuated with extended cell passage. After 30 passages, virus released from the cells lost virulence as shown by its inability to kill intracranially infected mice. The avirulent virus released from the persistently infected cells was more efficient in infecting and replicating in naive U937 cells than the virus which was used to establish the persistent infection. These results suggest that macrophages may serve as reservoirs of infection in vivo, sequestering virus which may subsequently be activated from its persistent state, resulting in clinical infection and death. KW - cell culture KW - macrophages KW - strain differences KW - viral diseases KW - man KW - mice KW - rabies virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Lyssavirus KW - Rhabdoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - persistent infections KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Tissue and Cell Culture (LL700) KW - Laboratory Animal Science (LL040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952203306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. AU - Engelman, A. AU - Englund, G. AU - Orenstein, J. M. AU - Martin, M. A. AU - Craigie, R. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 5 SP - 2729 EP - 2736 SN - 0022-538X AD - Engelman, A.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962000998. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - genomes KW - HIV infections KW - human immunodeficiency viruses KW - molecular biology KW - mutants KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000998&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus. AU - Arthur, L. O. AU - Bess, J. W. Jr AU - Urban, R. G. AU - Strominger, J. L. AU - Morton, W. R. AU - Mann, D. L. AU - Henderson, L. E. AU - Benveniste, R. E. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 5 SP - 3117 EP - 3124 SN - 0022-538X AD - Arthur, L. O.: AIDS Vaccine Program, PRI/DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962001016. Publication Type: Journal Article. Language: English. Number of References: 59 ref. KW - animal models KW - genetics KW - immunization KW - infections KW - viral diseases KW - Macaca KW - monkeys KW - simian immunodeficiency virus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - immune sensitization KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001016&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. AU - Englund, G. AU - Theodore, T. S. AU - Freed, E. O. AU - Engelman, A. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 5 SP - 3216 EP - 3219 SN - 0022-538X AD - Englund, G.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001005. Publication Type: Journal Article. Language: English. Number of References: 34 ref. KW - genetics KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - molecular biology KW - monocytes KW - polymerase chain reaction KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001005&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inducible and conditional inhibition of human immunodeficiency virus proviral expression by vascular stomatitis virus matrix protein. AU - Paik, S. Y. AU - Banerjea, C. AU - Harmison, G. G. AU - Chen, C. J. AU - Schubert, M. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 6 SP - 3529 EP - 3537 SN - 0022-538X AD - Paik, S. Y.: Correspondence address: M. Schubert, Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bldg. 36, Rm. 5W21, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009353. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. KW - acquired immune deficiency syndrome KW - cells KW - dna KW - gene expression KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - latent infections KW - molecular biology KW - pathogenesis KW - regulation KW - transcription KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - deoxyribonucleic acid KW - DNA transcription KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - reactivation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009353&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1. AU - Lusso, P. AU - Cocchi, F. AU - Balotta, C. AU - Markham, P. D. AU - Louie, A. AU - Farci, P. AU - Pal, R. AU - Gallo, R. C. AU - Reitz, M. S. Jr. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 6 SP - 3712 EP - 3720 SN - 0022-538X AD - Lusso, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg 37, Rm. 6A09, 37 Convent Dr., Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952008733. Publication Type: Journal Article. Language: English. Number of References: 49 ref. KW - cellular biology KW - human diseases KW - human immunodeficiency viruses KW - infectivity KW - macrophages KW - molecular biology KW - T lymphocytes KW - tropisms KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cell biology KW - cell tropism KW - human immunodeficiency virus KW - superinfections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008733&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that flavivirus NS1-NS2A cleavage is mediated by a membrane-bound host protease in the endoplasmic reticulum. AU - Falgout, B. AU - Markoff, L. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 11 SP - 7232 EP - 7243 SN - 0022-538X AD - Falgout, B.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19970500281. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Previous deletion mutagenesis studies have shown that the flavivirus NS1-NS2A cleavage requires the 8 C-terminal residues of NS1, constituting the cleavage recognition sequence, and sequences in NS2A far downstream of the cleavage site. The authors have now shown (using recombinant vaccinia viruses) that replacement of all of NS1 upstream of the cleavage recognition sequence with prM sequences still allows cleavage in vivo. Thus, other than the 8 C-terminal residues, NS1 is dispensable for NS1-NS2A cleavage. However, deletion of the N-terminal signal sequence abrogated cleavage, suggesting that entry into the exocytic pathway is required. Cleavage in vivo was not blocked by brefeldin A, and cleavage could occur in vitro in the presence of dog pancreas microsomes, indicating that NS1-NS2A cleavage occurs in the endoplasmic reticulum (ER). Four in-frame deletions in NS2A were cleavage defective in vitro, as were 2 mutants in which NS4A-NS4B sequences were substituted for NS2A, suggesting that most of NS2A is required. A series of substitution mutants were constructed in which all Asp, Cys, Glu, His and Ser residues in NS2A were collectively replaced; all standard proteases require at least one of these residues in their active sites. No single mutant was cleavage defective, suggesting that NS2A is not a protease. Fractionation of the microsomes indicated that the lumenal contents were not required for NS1-NS2A cleavage. It seems most likely that NS1-NS2A cleavage is effected by a host membrane-bound ER-resident protease, quite possibly signalase, and that NS2A is required to present the cleavage recognition sequence in the correct conformation to the host enzyme for cleavage. KW - arboviruses KW - cleavage KW - endoplasmic reticulum KW - membranes KW - proteinases KW - viral proteins KW - Flavivirus KW - vaccinia virus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - arthropod-borne viruses KW - nonstructural proteins KW - proteases KW - signalase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500281&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes. AU - Schubert, U. AU - Clouse, K. A. AU - Strebel, K. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 12 SP - 7699 EP - 7711 SN - 0022-538X AD - Schubert, U.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Rm 314, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19962000217. Publication Type: Journal Article. Language: English. Number of References: 68 ref. KW - cell lines KW - cells KW - culture techniques KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - Vpu protein KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000217&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. AU - Priola, S. A. AU - Chesebro, B. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 12 SP - 7754 EP - 7758 SN - 0022-538X AD - Priola, S. A.: Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. N1 - Accession Number: 19952221953. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - Recombinant hamster/mouse normal host PrP (PrP-sen) was expressed in scrapie-infected mouse neuroblastoma cells to identify specific PrP amino acid residues required for the conversion to protease resistant PrP (PrP-res). It was shown that homology to the region of mouse PrP-sen for residues 112 to 138 was required for conversion of recombinant PrP-sen to PrP-res in scrapie-infected mouse cells. A single hamster-specific PrP amino acid at residue 138 inhibited this conversion. The results support studies in man which show that specific amino acid residue changes within PrP can affect disease pathogenesis and transmission of transmissible spongiform encephalopathies across species barriers. KW - amino acids KW - cell cultures KW - disease transmission KW - inhibition KW - prions KW - proteinases KW - recombination KW - scrapie KW - spongiform encephalopathy KW - hamsters KW - mice KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic recombination KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952221953&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages. AU - Hui, R. AU - Curtis, J. F. AU - Sumner, M. T. AU - Shears, S. B. AU - Glasgow, W. C. AU - Eling, T. E. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 12 SP - 8020 EP - 8026 SN - 0022-538X AD - Hui, R.: Correspondence address: T.E. Eling, Eicosanoid Biochemistry Section, Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19962000222. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 11000-26-3. KW - CD4 antigens KW - cells KW - envelope protein gp120 KW - HIV infections KW - human diseases KW - monocytes KW - prostaglandins KW - receptors KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - gp120 KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000222&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a neurologic disease induced by a polytropic murine retrovirus: evidence for differential targeting of ecotropic and polytropic viruses in the brain. AU - Portis, J. L. AU - Czub, S. AU - Robertson, S. AU - McAtee, F. AU - Chesebro, B. JO - Journal of Virology JF - Journal of Virology Y1 - 1995/// VL - 69 IS - 12 SP - 8070 EP - 8075 SN - 0022-538X AD - Portis, J. L.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 58940, USA. N1 - Accession Number: 19962000223. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - animal models KW - brain KW - diseases KW - leukaemia KW - neurology KW - mice KW - retroviridae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RNA Reverse Transcribing Viruses KW - viruses KW - blood cancer KW - cerebrum KW - leucaemia KW - leukemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000223&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation and characterization of the gene encoding the surface membrane 3′-nucleotidase/nuclease of Leishmania donovani. AU - Debrabant, A. AU - Gottlieb, M. AU - Dwyer, D. M. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1995/// VL - 71 IS - 1 SP - 51 EP - 63 SN - 0166-6851 AD - Debrabant, A.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950807228. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9033-33-4. Subject Subsets: Protozoology N2 - Leishmania donovani and related trypanosomatid protozoa possess an externally oriented surface membrane enzyme capable of hydrolyzing both 3′-nucleotides and nucleic acids. By virtue of these activities, this 3′-nucleotidase/nuclease (3′-NT/Nu), previously shown to be analogous to fungal and plant class-I single-strand-specific nucleases, is thought to play a critical role in the salvage of purines, essential for the survival of these organisms. The 43 000 MW 3′-NT/Nu was purified from L. donovani promastigotes and treated with trypsin. Four of the released tryptic peptide fragments yielded amino-acid sequence information (Pept-1 to Pept-4) which provided the basis for the preparation of oligonucleotide primers for PCR amplification of an approximately 300-bp DNA fragment. This fragment was cloned, sequenced and used to probe a genomic L. donovani cosmid library. Nucleotide sequence analysis of a 4.5-kb SmaI fragment, isolated from a cosmid clone, revealed an open reading frame (ORF) of 1434 nt encoding a 477-amino-acid protein. Pept-1 to Pept-4 were mapped onto the ORF-deduced protein sequence. Peptides corresponding to Pept-1 to Pept-4 were synthesized and used to immunize rabbits. The resulting anti-peptide antibodies recognized the 43 000 MW protein on Western blots and immunoprecipitated the native 3′-nucleotidase activity from L. donovani membrane extracts. The ORF-deduced protein shared significant sequence identity with the S1 and P1 fungal nucleases of Aspergillus oryzae and Penicillium citrinum, respectively. It is concluded that the ORF corresponds to a gene for the L. donovani 3′-nucleotidase/nuclease. In Northern blots a nucleotide probe specific for the 3′-NT/Nu gene hybridized to a single 2.5-kb messenger RNA. Results of Southern blot analyses were consistent with the 3′-NT/Nu being encoded by a single-copy gene. This constitutes the first report of the gene for this unique trypanosomatid surface membrane enzyme. KW - amino acid sequences KW - genes KW - molecular genetics KW - nucleotidase KW - nucleotide sequences KW - open reading frames KW - parasites KW - Leishmania donovani KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - ORFs KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isoprenylation of proteins in the protozoan Giardia lamblia. AU - Luján, H. D. AU - Mowatt, M. R. AU - Chen, G. Z. AU - Nash, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1995/// VL - 72 IS - 1/2 SP - 121 EP - 127 SN - 0166-6851 AD - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950808188. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology N2 - The ability of Giardia lamblia [Giardia duodenalis] to modify several of its cellular proteins by isoprenylation is reported. Trophozoites cultured in the presence of [³H]mevalonate synthesized radiolabelled proteins of about 50 000 and 21 000 to 26 000 MW. Chemical analysis indicated that farnesyl and geranylgeranyl isoprenoids comprised the majority of the radiolabel covalently associated with trophozoite proteins. In addition, antibodies to human p21ras immunoprecipitated mevalonate-labelled species of MW about 21 000. Inhibitors of several enzymatic steps of the mevalonate pathway dramatically affected Giardia metabolism. Protein isoprenylation and cell growth were blocked by compactin and mevinolin, competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme in isoprenoid biosynthesis. In the presence of these inhibitors, Giardia growth was restored by the addition of mevalonate to the culture medium. In contrast, cell growth was blocked irreversibly by inhibitors of subsequent steps in the protein isoprenylation pathway. Trophozoite growth inhibition by limonene, perillic acid, perillyl alcohol and N-acetyl-S-farnesyl-l-cysteine was not reversed after the addition of mevalonate, dolichol, ubiquinone or cholesterol to the medium. These observations constitute the first description of protein isoprenylation in any protozoan and indicate that this post-translational modification is an important step in the regulation of the growth of this primitive eukaryote. KW - modification KW - parasites KW - proteins KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - protein isoprenylation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The structure of the large subunit rRNA expressed in blood stages of Plasmodium falciparum. AU - Waters, A. P. AU - White, W. AU - McCutchan, T. F. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1995/// VL - 72 IS - 1/2 SP - 227 EP - 237 SN - 0166-6851 AD - Waters, A. P.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19950808201. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology N2 - The sequence of the large subunit (LSU) rRNA expressed in blood-stage forms (and therefore A-type) of Plasmodium falciparum from 2 different isolates is presented. The genomic sequence was determined of an rRNA unit of the CAMP parasite strain from within the internal transcribed spacer 1 (ITS1) through the 5.8 S rRNA gene, the ITS2 and the entire large subunit rRNA gene. The corresponding sequence of the gene of the FVO strain was also determined by sequencing cDNA clones derived from blood-stage asexual parasites. Differences between the 2 were due to scattered point mutations in expansion segments of the mature rRNA regions. In addition to the point mutations, the rRNA genes from the 2 strains could be distinguished by the presence of a more complex polymorphism near the 3′ end of the molecule. The most complex polymorphic form was localized on a single chromosome and found in only a subset of geographically distinct isolates. The sequences of the 5.8 S rRNA unit and the LSU rRNA unit could be logically assembled into a complete secondary structure which conforms to the standard structure conserved in all eukaryotic ribosomes. The construction of a model of secondary structure for the LSU rRNA allowed the identification of phylogenetically conserved sequences involved in drug interaction with the ribosome, as well as those sequences involved in tertiary interactions within the rRNA itself. KW - drug resistance KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - polymorphism KW - ribosomal RNA KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808201&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hymenoptera, hypersensitivity, and history: a prologue to current day concepts and practices in the diagnosis, treatment, and prevention of insect sting allergy. AU - Cohen, S. G. AU - Bianchine, P. J. JO - Annals of Allergy, Asthma, & Immunology JF - Annals of Allergy, Asthma, & Immunology Y1 - 1995/// VL - 74 IS - 3 SP - 198 EP - 221 AD - Cohen, S. G.: National Institute of Allergy and Infectious Diseases, Solar Bldg., Rm 2C 37, Bethesda, MD 20892, USA. N1 - Accession Number: 19960200297. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition N2 - This review, with 147 references, deals with the evolution of the sting and the history of investigations into the nature of sting allergy and how it could be treated. There are also short sections on honey and the therapeutic uses of Hymenoptera (including honey bee) venom. KW - allergies KW - arthropod allergies KW - diagnosis KW - history KW - pathogenesis KW - stings KW - treatment KW - Hymenoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Apiculture (LL010) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Other Produce (QQ070) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960200297&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mapping of the intermolecular association of the human T cell leukaemia/lymphotropic virus type I p121 and the vacuolar H+-ATPase 16 kDa subunit protein. AU - Koralnik, I. J. AU - Mulloy, J. C. AU - Andresson, T. AU - Fullen, J. AU - Franchini, G. JO - Journal of General Virology JF - Journal of General Virology Y1 - 1995/// VL - 76 IS - 8 SP - 1909 EP - 1916 SN - 0022-1317 AD - Koralnik, I. J.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 37 Convent Dr MSC 4255, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962002121. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 147-85-3. KW - human diseases KW - mapping KW - mutants KW - proline KW - proteins KW - vacuoles KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - cartography KW - HTLV-BLV group KW - molecules KW - protein biology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002121&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. AU - Brindley, P. J. AU - Gam, A. A. AU - McKerrow, J. H. AU - Neva, F. A. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 80 IS - 1 SP - 1 EP - 7 SN - 0014-4894 AD - Brindley, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805055. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases N2 - The Strongyloides stercoralis zinc endopeptidase had a MW of 40 000 and a pI of 5 by zymogram analysis. Activity was not affected by incubation with β-mercaptoethanol at 22°C, but was inactivated by incubation at 100°C for 2 minutes. The enzyme (designated Ss40) is immunogenic and stimulates humoral IgG antibodies during infection of humans; the activity was immunoprecipitable from ES with pooled infection sera. A HPLC-enriched Ss40 preparation stimulated the release of histamine from peripheral blood leukocytes of people infected with S. stercoralis, suggesting that it is allergenic in humans. KW - allergens KW - antigens KW - enzymes KW - excretory secretory products KW - helminths KW - human diseases KW - IgG KW - immune response KW - immunoglobulins KW - larvae KW - parasites KW - proteinases KW - man KW - nematoda KW - Rhabditida KW - Strongyloides stercoralis KW - Strongyloididae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - antigenicity KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - proteases KW - Secernentea KW - zinc endopeptidase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unique specificity of in vitro inhibition of mosquito midgut trypsin-like activity correlates with in vitro inhibition of malaria parasite infectivity. AU - Shahabuddin, M. AU - Criscio, M. AU - Kaslow, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 80 IS - 2 SP - 212 EP - 219 SN - 0014-4894 AD - Shahabuddin, M.: Molecular Vaccine Section, Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950805835. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9002-07-7. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Aedes aegypti midgut trypsin-like proteases were characterized biochemically and compared to a mammalian trypsin. Mosquito trypsin was more sensitive to inhibition by aprotinin and less sensitive to egg white trypsin inhibitor than was bovine pancreatic trypsin. Soybean trypsin inhibitor and leupeptin inhibited both enzymes to a similar extent. Membrane-feeding assays with aprotinin, leupeptin, and egg white trypsin inhibitor revealed a correlation between in vitro inhibition of mosquito trypsin-like activity and in vivo inhibition of sporogonic development (of Plasmodium gallinaceum). The trypsin inhibitors did not interfere with mosquito survival or egg development. The results suggest a role for mosquito midgut trypsin(s) in malaria parasite development and indicate that the protease(s) is a potential target for blocking malaria transmission. KW - biochemistry KW - development KW - disease vectors KW - enzyme inhibitors KW - host parasite relationships KW - infectivity KW - inhibition KW - midgut KW - parasites KW - trypsin KW - Aedes aegypti KW - Apicomplexa KW - Culicidae KW - Diptera KW - Plasmodiidae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Protozoa KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - aprotinin KW - leupeptin KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805835&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae. AU - Vernick, K. D. AU - Fujioka, H. AU - Seeley, D. C. AU - Tandler, B. AU - Aikawa, M. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 80 IS - 4 SP - 583 EP - 595 SN - 0014-4894 AD - Vernick, K. D.: Molecular Entomology Section, Laboratory of Malaria Research, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950806551. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - A mechanism for refractoriness to P. gallinaceum was identified in the African vector of human malaria, A. gambiae. Oocysts failed to develop in the refractory mosquitoes as a result of ookinete death, which occurs within 27 h of midgut invasion. Ultrastructural studies showed that parasite death occurs while the ookinete lies free in the midgut epithelial cell cytosol, usually surrounded by an organelle-free zone that consists of finely fibrillar material. The mechanism of parasite killing did not involve a previously described refractory mechanism of parasite encapsulation. Genetic lines were selected which were refractory or susceptible to midgut infection. Genetic crossing of the lines indicated that the refractory trait is inherited as a single dominant genetic locus. Other loci probably influence oocyst number in susceptible mosquitoes. KW - disease vectors KW - host parasite relationships KW - parasites KW - susceptibility KW - vector competence KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950806551&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status. AU - Friedman, T. C. AU - Yanovski, J. A. AU - Jayasvasti, V. AU - Yanovski, S. Z. AU - Koenig, R. J. AU - Wilk, S. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1995/// VL - 80 IS - 4 SP - 1086 EP - 1089 SN - 0021-972X AD - Friedman, T. C.: Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951406983. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition KW - activity KW - blood KW - body weight KW - hyperthyroidism KW - hypothyroidism KW - obesity KW - serum KW - thyroid gland KW - thyroid hormones KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - hyperthyroidosis KW - thyroid KW - thyrotoxicosis KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406983&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. AU - Baird, D. D. AU - Umbach, D. M. AU - Lansdell, L. AU - Hughes, C. L. AU - Setchell, K. D. R. AU - Weinberg, C. R. AU - Haney, A. F. AU - Wilcox, A. J. AU - McLachlan, J. A. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1995/// VL - 80 IS - 5 SP - 1685 EP - 1690 SN - 0021-972X AD - Baird, D. D.: National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina, NC 27709, USA. N1 - Accession Number: 19951408068. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9002-68-0, 9002-67-9. Subject Subsets: Human Nutrition; Soyabeans N2 - The hypothesis that postmenopausal women on a soya-supplemented diet show oestrogenic responses was tested. 97 postmenopausal women consumed soya foods for 4 weeks or ate their usual diet (controls). Changes in urinary isoflavone concentrations served as a measure of compliance and phytoestrogen dose. Changes in serum FSH, LH, sex hormone binding globulin and vaginal cytology were measured to assess oestrogenic response. The percentage of vaginal superficial cells (indicative of oestrogenicity) increased for 19% of those eating the soya diet compared with 8% of controls (P = 0.06 when tested by ordinal logistic regression). FSH and LH did not decrease significantly with dietary supplementation as hypothesized, nor did sex hormone binding globulin increase. Little change occurred in endogenous estradiol concentration or body weight during the diet. Women with large increases in urinary isoflavone concentrations were not more likely to show oestrogenic responses than were women with more modest increases. On the basis of published estimates of phytoestrogen potency, a 4-week, soya-supplemented diet was expected to have oestrogenic effect on the liver and pituitary in post-menopausal women, but oestrogenic effects were not seen. At most, there was a small oestrogenic effect on vaginal cytology. KW - binding proteins KW - blood KW - cytology KW - FSH KW - LH KW - plant oestrogens KW - reproductive organs KW - sex hormones KW - soyabean products KW - soyabeans KW - supplements KW - vagina KW - women KW - Glycine (Fabaceae) KW - man KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - carrier proteins KW - follicle stimulating hormone KW - follitropin KW - luteinizing hormone KW - phytoestrogens KW - plant estrogens KW - soybean products KW - soybeans KW - Crop Produce (QQ050) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408068&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enzyme-linked immunosorbent assay for detection of serum antibody to Blastocystis hominis in symptomatic infections. AU - Zierdt, C. H. AU - Zierdt, W. S. AU - Nagy, B. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1995/// VL - 81 IS - 1 SP - 127 EP - 129 SN - 0022-3395 AD - Zierdt, C. H.: Microbiology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950804782. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Protozoology; Public Health N2 - An enzyme-linked immunosorbent assay was devised in order to search for antibodies against Blastocystis hominis in infected humans. Reaction proteins were obtained from washed, axenic B. hominis cells, as sonicate. The sonicate was diluted to provide 17 and 34 µg of protein per well. Dilutions of patients' sera were applied, followed by phosphatase-conjugated goat anti-human serum and phosphatase substrate. Colour was measured at 405 µm wavelength. Immunoglobulin G antibodies to high titres were found. Of 30 sera tested from 28 patients, 3 were negative at the 1/50 threshold dilution, 8 were positive at 1/50, 3 at 1/100, 2 at 1/200, 3 at 1/400, 6 at 1/800, and 5 at 1/1600. Normal sera (42 blood bank sera) were all negative at 1/50. Each serum was subjected to multiple testing. Duplicate tests were included for each run, and runs were made from 4 to 6 for each serum. B. hominis is increasingly recognized to be a cause of human enteric disease, with symptoms often like those in giardiasis. Demonstration of strong antibody response is consistent with this view. KW - detection KW - ELISA KW - human diseases KW - immunodiagnosis KW - infections KW - parasites KW - seroprevalence KW - serum KW - blastocystis hominis KW - man KW - protozoa KW - Blastocystis KW - Amoebida incertae sedis KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - enzyme linked immunosorbent assay KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: sporozoite invasion of Aedes aegypti salivary glands is inhibited by anti-gland antibodies and by lectins. AU - Barreau, C. AU - Touray, M. AU - Pimenta, P. F. AU - Miller, L. H. AU - Vernick, K. D. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 81 IS - 3 SP - 332 EP - 343 SN - 0014-4894 AD - Barreau, C.: Laboratory of Parasitic Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960801357. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Purified sporozoites from mature oocysts of Plasmodium gallinaceum were injected into Aedes aegypti. Half of the maximum invasion of salivary glands by sporozoites occurred by 6 h, and salivary gland sporozoite load did not increase after 24 h postinjection. A rabbit polyclonal antiserum was raised against female A. aegypti salivary glands which recognized tissue-specific determinants in the basal lamina of salivary glands. The purified IgG antibody fraction of the immune serum blocked sporozoite invasion in vivo. 7 of 19 lectins tested bound to salivary glands, and of these, succinylated wheat germ agglutinin and wheat germ agglutinin completely blocked sporozoite invasion. Pisum sativum agglutinin and soybean agglutinin partially blocked, and concanavalin A, Dolichos biflorus agglutinin, and Phaseolus vulgaris erythroagglutinin did not block, invasion. It is suggested that sporozoites interact with glycosylated salivary gland surface molecules, which serve as receptors for invasion, and which may be in the salivary gland basal lamina. KW - antibodies KW - disease vectors KW - igg KW - immunoglobulins KW - invasion KW - lectins KW - parasites KW - salivary glands KW - sporozoites KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - gamma-globulins KW - immune globulins KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: mosquito peritrophic matrix and the parasite-vector compatibility. AU - Shahabuddin, M. AU - Kaidoh, T. AU - Aikawa, M. AU - Kaslow, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 81 IS - 3 SP - 386 EP - 393 SN - 0014-4894 AD - Shahabuddin, M.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960801359. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Sporogonic development of Plasmodium gallinaceum was studied in susceptible (Aedes aegypti and Anopheles gambiae G3) and refractory (A. stephensi) mosquitoes. In the presence of the PM (peritrophic matrix) the number of oocysts that developed in A. gambiae G3 was about 20% of that in Aedes aegypti; no oocysts developed in Anopheles stephensi. The absence of the PM did not increase the susceptibility of Aedes aegypti or Anopheles gambiae nor did it make A. stephensi susceptible. It is concluded that the PM is not the primary determinant of P. gallinaceum compatibility in these mosquitoes. KW - compatibility KW - disease vectors KW - host parasite relationships KW - parasites KW - peritrophic membrane KW - susceptibility KW - Aedes aegypti KW - Anopheles gambiae KW - Anopheles stephensi KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium: a quantitative molecular assay for detection of sporogonic-stage malaria parasites. AU - Vernick, K. D. AU - Barreau, C. AU - Seeley, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 81 IS - 4 SP - 436 EP - 444 SN - 0014-4894 AD - Vernick, K. D.: Laboratory of Parasitic Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960801954. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - A molecular assay for the detection of malaria parasites during sporogonic development in the mosquito host is described. Specific primers for Plasmodium-specific small-subunit ribosomal RNA sequences not present in mosquito RNA were used in a reverse transcriptase-polymerase chain reaction assay. The study was carried out using Plasmodium gallinaceum from Aedes aegypti. Ookinetes and sporozoites were both recognized in the assay. The assay allowed accurate quantification of parasite number over at least two orders of magnitude, from 10-1000 sporozoites. KW - detection KW - disease vectors KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - ribosomal RNA KW - techniques KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - biochemical genetics KW - mosquitoes KW - PCR KW - rRNA KW - small subunit ribosomal RNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation. AU - Alleman, M. M. AU - Mann, V. H. AU - Bacchi, C. J. AU - Yarlett, N. AU - Gottlieb, M. AU - Dwyer, D. M. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1995/// VL - 81 IS - 4 SP - 519 EP - 528 SN - 0014-4894 AD - Alleman, M. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960801963. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology N2 - The utilization of S-adenosyl-L-[methyl-³H]methionine ([³H-methyl]AdoMet) by Crithidia luciliae was assessed under nutrient-replete and purine-starvation conditions. The radiolabel from this molecule was accumulated by purine-starved organisms at a rate about 10-fold greater than that observed in those cultivated in nutrient-replete medium. It is suggested that differences observed in [³H-methyl]AdoMet utilization between purine-starved and nutrient-replete C. luciliae may reflect the enhanced purine transport capacity which results from purine starvation. KW - biochemistry KW - methylation KW - parasites KW - proteins KW - purines KW - uptake KW - Crithidia luciliae KW - protozoa KW - Crithidia KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - purine bases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmaceutical prospecting and the potential for pharmaceutical crops. Natural product drug discovery and development at the United States National Cancer Institute. AU - Cragg, G. M. AU - Boyd, M. R. AU - Grever, M. R. AU - Schepartz, S. A. JO - Annals of the Missouri Botanical Garden JF - Annals of the Missouri Botanical Garden Y1 - 1995/// VL - 82 IS - 1 SP - 47 EP - 53 SN - 0026-6493 AD - Cragg, G. M.: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950307309. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - Chemically complex natural product drugs are not readily synthesized, and large scale production for clinical and commercial development often involves isolation from the natural source. The rapidly escalating demand for taxol, originally isolated from the bark of Taxus brevifolia, has emphasized the need for alternative sources to the wild plant, and the National Cancer Institute (NCI) has developed policies for exploring such sources at the early stages of preclinical development of potential new drugs. The potential for pharmaceutical crop development is discussed with reference to plants containing possible anti-AIDS agents. KW - acquired immune deficiency syndrome KW - antiviral properties KW - bark KW - diterpenoid alkaloids KW - drugs KW - medicinal plants KW - medicinal properties KW - natural products KW - plant composition KW - production KW - production possibilities KW - research KW - Taxaceae KW - Taxus brevifolia KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Taxus KW - Taxaceae KW - AIDS KW - anti-viral properties KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - medicines KW - officinal plants KW - pharmaceuticals KW - potential production KW - production potential KW - studies KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Plant Production (FF100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950307309&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. AU - Su XinZhuan AU - Heatwole, V. M. AU - Wertheimer, S. P. AU - Guinet, F. AU - Herrfeldt, J. A. AU - Peterson, D. S. AU - Ravetch, J. A. AU - Wellems, T. E. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1995/// VL - 82 IS - 1 SP - 89 EP - 100 SN - 0092-8674 AD - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800987. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Plasmodium falciparum evades host immunity by varying the antigenic and adhesive character of infected erythrocytes. A large and extremely diverse family of P. falciparum genes (var) that encode 200 000-350 000 proteins having the expected properties of antigenically variant adhesion molecules is described. Predicted amino acid sequences of var genes show a variable extracellular segment with domains having receptor-binding features, a transmembrane sequence and a terminal segment that is a probable submembrane anchor. There are 50-150 var genes on multiple parasite chromosomes, and some are in clustered arrangements. Probes detected two classes of var transcripts in steady-state RNA: 7.9 kb var transcripts, and an unusual family of 1.8-2.4 kb transcripts that may be involved in the expression or rearrangements of var genes. KW - adhesion KW - antigenic variation KW - antigens KW - chromosomes KW - erythrocytes KW - gene expression KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - rna probes KW - transcription KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - biochemical genetics KW - blood red cells KW - DNA sequences KW - DNA transcription KW - immunogens KW - red blood cells KW - variant surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800987&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Switches in expression of Plasmodium falciparumvar genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. AU - Smith, J. D. AU - Chitnis, C. E. AU - Craig, A. G. AU - Roberts, D. J. AU - Hudson-Taylor, D. E. AU - Peterson, D. S. AU - Pinches, R. AU - Newbold, C. I. AU - Miller, L. H. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1995/// VL - 82 IS - 1 SP - 101 EP - 110 SN - 0092-8674 AD - Smith, J. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800989. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Plasmodium falciparum expresses clonally variant antigens and ligands on the host erythrocyte surface that mediate adherence to endothelial receptors. Both are central to pathogenesis since they allow chronicity of infection and lead to the concentration of infected erythrocytes in cerebral blood vessels. The expression of variant antigenic determinants is shown to be correlated with the expression of individual members of a large multigene family named var. Each var gene contains copies of a motif that has been previously shown to bind diverse host receptors. Expression of a specific var gene correlated with binding to intercellular adhesion molecule 1 (ICAM-1). The findings are consistent with the involvement of var genes in antigenic variation and endothelial binding. KW - adhesion KW - antigenic variation KW - antigens KW - binding sites KW - blood vessels KW - brain KW - endothelium KW - erythrocytes KW - genes KW - ligands KW - molecular genetics KW - nucleotide sequences KW - parasites KW - pathogenicity KW - receptors KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - binding site KW - biochemical genetics KW - blood red cells KW - cerebrum KW - DNA sequences KW - immunogens KW - red blood cells KW - variant surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800989&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Primary mycotic abscess of the brain caused by Fonsecaea pedrosoi. Case report. AU - Vani Santosh AU - Neelam Khanna AU - Shankar, S. K. AU - Lily Pal AU - Sarala Das AU - Akepatti Chandramukhi AU - Kolluri, V. R. S. JO - Journal of Neurosurgery JF - Journal of Neurosurgery Y1 - 1995/// VL - 82 IS - 1 SP - 128 EP - 130 SN - 0022-3085 AD - Vani Santosh: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. N1 - Accession Number: 19951201701. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a non-immunocompromised 15-yr-old boy from India who presented with a 4-month history of headache, vomiting and blurred vision, and a 10-d history of right sensory seizures. Computed tomography of the head revealed a large, well-demarcated mixed density lesion with cystic areas and focal calcification in the left temporal region. The abscess was surgically removed. Histopathological examination of the resected lesion revealed brown-pigmented fungal hyphae and F. pedrosoi was cultured. The patient recovered completely after surgery and treatment with amphotericin B and flucytosine. KW - brain KW - case reports KW - children KW - hosts KW - human diseases KW - infections KW - phaeohyphomycosis KW - India KW - man KW - Phialophora pedrosoi KW - Fonsecaea KW - Herpotrichiellaceae KW - Chaetothyriales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - Phialophora KW - cerebrum KW - chromomycosis KW - Fonsecaea pedrosoi KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201701&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - EEG abnormalities, malnutrition, parasitism and goitre: a study of schoolchildren in Ecuador. AU - Levav, M. AU - Cruz, M. E. AU - Mirsky, A. F. JO - Acta Paediatrica JF - Acta Paediatrica Y1 - 1995/// VL - 84 IS - 2 SP - 197 EP - 202 SN - 0803-5253 AD - Levav, M.: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Building 10, Room 4C110, 10 Center DR MSC 1366 Bethesda, MD 20892-1366, USA. N1 - Accession Number: 19951408428. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition; Protozoology; Helminthology; Tropical Diseases N2 - Data collected from 194 school children (9 to 13 years old) residing in a mountainous community in Ecuador are reported. This study was part of an ongoing epidemiological inquiry into the prevalence of parasitism, malnutrition, neurocysticercosis, goitre, iodine levels and EEG abnormalities, and the relationships among these factors. Data were obtained by a local medical team supported by specialized personnel. The results showed that 34% of the EEG tracings were abnormal, with higher rates among girls. The best fitted log-linear model to explain the results was the combination of EEG status, parasite infection, goitre and gender. The best predictor of EEG abnormalities was found to be a diagnosis of goitre. KW - children KW - electroencephalography KW - epidemiology KW - goitre KW - health KW - helminths KW - iodine KW - malnutrition KW - metacestodes KW - parasites KW - parasitoses KW - school children KW - surveys KW - Ecuador KW - South America KW - Ascaris lumbricoides KW - Enoplida KW - man KW - protozoa KW - Taenia solium KW - Trichuris trichiura KW - Ascaris KW - Ascarididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - Trichuris KW - Trichuridae KW - Trichinellida KW - Dorylaimia KW - Enoplea KW - Enoplia KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Adenophorea KW - Ascaridida KW - EEG KW - goiter KW - nematodes KW - parasitic diseases KW - parasitic infestations KW - parasitic worms KW - parasitosis KW - pork tapeworm KW - school kids KW - schoolchildren KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408428&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. AU - Foli, A. AU - Saville, M. W. AU - Baseler, M. W. AU - Yarchoan, R. JO - Blood JF - Blood Y1 - 1995/// VL - 85 IS - 8 SP - 2114 EP - 2123 SN - 0006-4971 AD - Foli, A.: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005763. Publication Type: Journal Article. Language: English. Number of References: 70 ref. KW - cell mediated immunity KW - cytokines KW - HIV infections KW - human immunodeficiency viruses KW - immune response KW - immunology KW - interleukins KW - replication KW - T lymphocytes KW - viral replication KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cellular immunity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T cells KW - TH1 responses KW - TH2 responses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005763&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular mechanisms of human T-cell leukemia/lymphotropic virus type 1 infection. AU - Franchini, G. JO - Blood JF - Blood Y1 - 1995/// VL - 86 IS - 10 SP - 3619 EP - 3639 SN - 0006-4971 AD - Franchini, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962000656. Publication Type: Journal Article. Language: English. Number of References: 318 ref. KW - clinical aspects KW - genetics KW - HTLV-I infections KW - human diseases KW - pathogenesis KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - proliferation KW - tropical spastic parapareses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000656&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adenocarcinoma of the esophagus: role of obesity and diet. AU - Brown, L. M. AU - Swanson, C. A. AU - Gridley, G. AU - Swanson, G. M. AU - Schoenberg, J. B. AU - Greenberg, R. S. AU - Silverman, D. T. AU - Pottern, L. M. AU - Hayes, R. B. AU - Schwartz, A. G. AU - Liff, J. M. AU - Fraumeni, J. F., Jr. AU - Hoover, R. N. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1995/// VL - 87 IS - 2 SP - 104 EP - 109 SN - 0027-8874 AD - Brown, L. M.: National Institutes of Health, Executive Plaza North, Rm 415, Bethesda, MD 20892, USA. N1 - Accession Number: 19951408425. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition N2 - This study investigates dietary and nutritional risk factors for adenocarcinoma of the oesophagus. 174 white men (30 to 79 years old) with adenocarcinoma of the oesophagus and 750 control subjects living in 3 areas of the USA were studied during 1986 through 1989. Risk was significantly elevated for subjects in the heaviest quartile compared with the lightest quartile of body mass index (odds ratio (OR) = 3.1; 95% confidence interval [C1] = 1.8-5.3). No significant associations were seen with the total energy intake, number of meals eaten daily, fat intake or consumption of coffee and tea. Risks were highest for those consuming the least amount of vegetables, with some evidence of a dose response for the subcategories of cruciferous vegetables (P≤0.001) and vegetables consumed raw (P=0.10). An elevated risk was also seen for those consuming the least amount of raw fruit (P=0.05). No clear associations were reported for intake of particular micronutrients overall or in supplements, but a protective effect was associated with increasing intake of dietary fibre (P=0.004). It is concluded that an increased risk with obesity and decreased risks with intake of raw fruits and vegetables, and dietary fibre are found. KW - carcinoma KW - diet studies KW - fibre KW - fruits KW - obesity KW - oesophagus KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - esophagus KW - fatness KW - fiber KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408425&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent cancer trends in the United States. AU - Devesa, S. S. AU - Blot, W. J. AU - Stone, B. J. AU - Miller, B. A. AU - Tarone, R. E. AU - Fraumeni, J. F. Jr JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1995/// VL - 87 IS - 3 SP - 175 EP - 182 SN - 0027-8874 AD - Devesa, S. S.: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892-7368, USA. N1 - Accession Number: 19952002941. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Public Health N2 - Cancer incidence rates have been reported to be increasing in the USA, although trends vary according to form of cancer. The authors identified the cancers accounting for the rising incidence, quantified the changes that occurred from the mid-1970s to the early 1990s. They subsequently compared incidence and mortality trends to provide clues to the determinants of the temporal patterns. Sex-, race-, and age-specific and age-adjusted incidence rates for the 5-year periods 1987-1991 versus 1975-1979 were calculated for 28 cancers among men and 30 cancers among women using data from the Surveillance, Epidemiology, and End Results (SEER) Programme of cancer registration covering about 10% of the US population. Similar rates were computed using national mortality data. Cancers were ranked according to the change in incidence rates over the 2 periods. The age-adjusted incidence rates for all cancers combined increased by 18.6% among males and 12.4% among females from 1975-1979 to 1987-1991, due largely to rising rates for prostate cancer among men and for breast and lung cancers among women. National mortality rates for all cancers combined rose less steeply, 3% and 6% among men and women, respectively, driven mostly by continuing increases in lung cancer mortality, while death rates for the majority of the cancers were steady or declining. Total cancer incidence rose at all ages, but with different tumours responsible for the increases at different ages: leukaemia and brain/nervous system cancer among children; testicular cancer, non-melanoma skin cancer (largely Kaposi's sarcoma), non-Hodgkin's lymphoma, and melanoma among young and middle-aged adults; and prostate, breast, and lung cancers among older individuals. In contrast, mortality rates for all cancers combined declined among both males and females under 55 years of age, increasing only among older persons. Trends in cancer incidence and mortality differ. For most cancers, incidence rates are rising, while mortality rates are generally stable or declining. Much of the recent increase in cancer incidence can be explained by known factors. Improved detection appears to account for most of the increases in breast cancer among women and prostate cancer among men. On the other hand, cigarette smoking is the major determinant of the rise in lung cancer among women, acquired immunodeficiency syndrome has led to increases in non-Hodgkin's lymphoma and Kaposi's sarcoma among young and middle-aged men, and sunlight exposure patterns have affected the trends in melanoma. Some trends remain unexplained, however, and may reflect changing exposures to carcinogens yet to be identified and clarified. KW - disease prevalence KW - human diseases KW - neoplasms KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002941&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Japanese encephalitis virus antigen in the human brain and its topographic distribution. AU - Desai, A. AU - Shankar, S. K. AU - Ravi, V. AU - Chandramuki, A. AU - Gourie-Devi, M. JO - Acta Neuropathologica JF - Acta Neuropathologica Y1 - 1995/// VL - 89 IS - 4 SP - 368 EP - 373 SN - 0001-6322 AD - Desai, A.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. N1 - Accession Number: 19960500737. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - This study reports the pathological findings and the distribution of viral antigen in the brains of 13 confirmed and autopsied cases of Japanese encephalitis (JE) in correlation with other virus-specific immunological parameters measured in the cerebrospinal fluid (CSF) antemortem. JE virus (JEV)-specific antibodies were detected in the CSF of 10 of 13 patients, JEV antigen was detected in the CSF of 7 of 13 and JEV-specific immune complexes were detected in the CSF of 3 of 11 patients. Viral antigen was localized immunocytochemically in the brain tissue of 11 of 13 cases, indicating that viral antigen could not be cleared from the tissues by the antibody. The topographic distribution of the tissue-associated antigen in the thalamus, hippocampus, substantia nigra and medulla oblongata explains the evolution of post JE sequelae. KW - antigens KW - arboviruses KW - brain KW - cerebrospinal fluid KW - human diseases KW - Japanese encephalitis KW - nervous system diseases KW - India KW - Karnataka KW - Japanese encephalitis virus KW - man KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - antigenicity KW - arthropod-borne viruses KW - cerebrum KW - immunogens KW - Mysore KW - neuropathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500737&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transfection of Plasmodium falciparum within human red blood cells. AU - Wu, Y. AU - Sifri, C. D. AU - Lei, H. H. AU - Su, X. Z. AU - Wellems, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 4 SP - 973 EP - 977 SN - 0027-8424 AD - Wu, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803865. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9040-07-7, 9007-49-2. Subject Subsets: Protozoology N2 - Plasmodium falciparum within human erythrocytes were successfully transfected to produce chloramphenicol acetyltransferase (CAT). Electroporation of parasitized erythrocytes was used to introduce plasmids that had CAT-encoding DNA flanked by 5′ and 3′ untranslated sequences of the P. falciparum hsp86, hrp3 and hrp2 genes. These flanking sequences were required for expression as their excision abolished CAT activity in transfected parasites. Transfection signals from native CAT-encoding DNA compared well with those from a synthetic DNA sequence adapted to the P. falciparum major codon bias, demonstrating effective expression of the bacterial sequence despite its use of rare P. falciparum codons. Transfected ring-stage parasites produced CAT signals at least as strong as transfected schizont-stage parasites, even though ring stages are surrounded by more erythrocyte cytoplasm than schizonts. KW - chloramphenicol acetyltransferase KW - developmental stages KW - DNA KW - erythrocytes KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - schizonts KW - transfection KW - Apicomplexa KW - Plasmodiidae KW - Plasmodium falciparum KW - protozoa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Haemospororida KW - Apicomplexa KW - Plasmodium KW - Plasmodiidae KW - biochemical genetics KW - blood red cells KW - deoxyribonucleic acid KW - DNA sequences KW - growth phase KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803865&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. AU - Shirasaka, T. AU - Kavlick, M. F. AU - Ueno, T. AU - Gao, W. Y. AU - Kojima, E. AU - Alcaide, M. L. AU - Chokekijchai, S. AU - Roy, B. M. AU - Arnold, E. AU - Yarchoan, R. AU - Mitsuya, H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 6 SP - 2398 EP - 2402 SN - 0027-8424 AD - Shirasaka, T.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006471. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9068-38-6. KW - dideoxynucleosides KW - drug combinations KW - drug resistance KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - reverse transcriptase KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006471&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Angiogenic properties of human immunodeficiency virus type 1 Tat protein. AU - Albini, A. AU - Barillari, G. AU - Benelli, R. AU - Gallo, R. C. AU - Ensoli, B. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 11 SP - 4838 EP - 4842 SN - 0027-8424 AD - Albini, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002086. Publication Type: Journal Article. Language: English. Number of References: 45 ref. KW - acquired immune deficiency syndrome KW - angiogenesis KW - cytokines KW - development KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - Tat protein KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002086&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transient transfection and expression of firefly luciferase in Giardia lamblia. AU - Yee, J. AU - Nash, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 12 SP - 5615 EP - 5619 SN - 0027-8424 AD - Yee, J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800443. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9007-49-2, 9001-46-1, 9029-11-2, 9029-12-3. Subject Subsets: Protozoology N2 - A gene transfer system was developed for Giardia lamblia [G. duodenalis], which is considered to be one of the most primitive eukaryotes. Expression of a heterologous gene was detected in this parasite after electroporation with appropriate DNA constructs. A series of transfection plasmids was constructed, using flanking sequences of the G. lamblia glutamate dehydrogenase (GDH) gene to drive expression of the firefly luciferase reporter gene. The optimal construct consisted of a GDH/luciferase fusion gene in which the first 18 codons of the GDH gene immediately preceded the luciferase gene; this fusion gene was flanked by the upstream and downstream sequences of the GDH gene. Electroporation of this construct into G. lamblia yielded luciferase activity that was 3000- to 50 000-fold above background. Removal of either the 5′ or 3′ GDH flanking sequences from this construct resulted in significantly reduced luciferase activity, and removal of both flanking sequences reduced luciferase activity to background levels. Luciferase activity was proportional to the amount of DNA electroporated and was maximal 6 h after electroporation. KW - DNA KW - electroporation KW - gene transfer KW - genes KW - glutamate dehydrogenase KW - luciferases KW - molecular genetics KW - parasites KW - plasmids KW - reporter genes KW - transfection KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - deoxyribonucleic acid KW - luciferase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800443&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues. AU - Jenkins, T. M. AU - Hickman, A. B. AU - Dyda, F. AU - Ghirlando, R. AU - Davies, D. R. AU - Craigie, R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 13 SP - 6057 EP - 6061 SN - 0027-8424 AD - Jenkins, T. M.: Correspondence address: R. Craigie, Building 5, Room 301, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001915. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9007-49-2. KW - DNA KW - genomes KW - HIV infections KW - human diseases KW - hydrophobicity KW - molecular biology KW - mutants KW - proteins KW - residues KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001915&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Direct evidence for secondary loss of mitochondria in Entamoeba histolytica. AU - Clark, C. G. AU - Roger, A. J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 14 SP - 6518 EP - 6521 SN - 0027-8424 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960803795. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Protozoology N2 - Archezoan protists are thought to represent lineages that diverged from other eukaryotes before the acquisition of mitochondria and other organelles. Entamoeba histolytica was originally included in this group, although ribosomal RNA-based phylogenies have placed this species on a comparatively recent branch of the eukaryotic tree which implies its ancestors had mitochondria. In this study, direct evidence for 2ndary loss of mitochondrial function was obtained by isolating 2 E. histolytica genes encoding proteins that in other eukaryotes are localized in the mitochondrion: the enzyme pyridine nucleotide transhydrogenase and the chaperonin cpn60. Phylogenetic analysis of the E. histolytica homologue of cpn60 confirmed that it is specifically related to the mitochondrial lineage. The data suggest that a mitochondrial relic may persist in this organism. KW - genes KW - mitochondria KW - molecular genetics KW - organelles KW - parasites KW - phylogeny KW - proteins KW - ribosomal RNA KW - Entamoeba histolytica KW - eukaryotes KW - protozoa KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803795&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men. AU - Müller, J. R. AU - Janz, S. AU - Goedert, J. J. AU - Potter, M. AU - Rabkin, C. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 14 SP - 6577 EP - 6581 SN - 0027-8424 AD - Müller, J. R.: Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972005585. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 308067-57-4. N2 - Blood lymphocytes of HIV-seropositive and HIV-negative homosexual men from the USA, were studied for the presence of T(8;14) translocations that recombine c-myc and immunoglobulin heavy-chain (IgH) µ/IgHα switch regions. Clones with T(8;14) translocations were detected in 12 (10.5%) of 114 HIV-positive and in 2.0% of 99 uninfected patients. The majority of recombinations were found at a single time point only. Four patients, however, harboured multiple (up to four) and persistent (up to 9 years) translocation-positive cell clones. No correlation between the presence of these aberrant lymphocytes and a later lymphoma was established. The exon 1/intron 1 region of the recombined c-myc was investigated for the presence of point mutations and these were found in the nonpersistent clones. Additional alterations detected in these clones included duplications and a deletion in the c-myc gene. The pattern of base substitutions indicated that they were introduced after the translocation event. KW - blood KW - hiv infections KW - homosexuality KW - human diseases KW - human immunodeficiency viruses KW - immunoglobulins KW - men KW - t lymphocytes KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - gamma-globulins KW - homosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune globulins KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005585&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins. AU - Peterson, D. S. AU - Miller, L. H. AU - Wellems, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 15 SP - 7100 EP - 7104 SN - 0027-8424 AD - Peterson, D. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960801008. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology N2 - Open reading frames in the Plasmodium falciparum genome encode domains homologous to the adhesive domains of the P. falciparum EBA-175 erythrocyte-binding protein (eba-175 gene product) and those of the P. vivax and P. knowlesi Duffy antigen-binding proteins. These domains are referred to as Duffy binding-like (DBL), after the receptor that determines P. vivax invasion of Duffy blood group-positive human erythrocytes. Using oligonucleotide primers derived from short regions of conserved sequence, a reverse transcription-PCR method was developed that amplified sequences encoding the DBL domains of expressed genes. Products of these reverse transcription-PCR amplifications included sequences of single-copy genes (including eba-175) and variably transcribed genes that cross-hybridized to multiple regions of the genome. Restriction patterns of the multicopy genes showed a high degree of polymorphism among different parasite lines, whereas single-copy genes were generally conserved. Characterization of the single-copy genes has identified a gene (ebl-1) that is related to eba-175 and is likely to be involved in erythrocyte invasion. KW - adhesion KW - binding KW - cell invasion KW - erythrocytes KW - genes KW - genomes KW - host parasite relationships KW - molecular genetics KW - nucleotide sequences KW - open reading frames KW - parasites KW - polymerase chain reaction KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - blood red cells KW - DNA sequences KW - erythrocyte binding protein KW - ORFs KW - parasite host relationships KW - PCR KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801008&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 2′,3′-dideoxynucleoside activities against replication of human immunodeficiency virus. AU - Gao WenYi AU - Johns, D. G. AU - Chokekijchai, S. AU - Mitsuya, H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 18 SP - 8333 EP - 8337 SN - 0027-8424 AD - Gao WenYi: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007153. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 127-07-1. KW - antiviral agents KW - dideoxynucleosides KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - hydroxycarbamide KW - purines KW - pyrimidines KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - hydroxyurea KW - purine bases KW - pyrimidine bases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007153&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Passive immunotherapy for retroviral disease: influence of major histocompatibility complex type and T-cell responsiveness. AU - Hasenkrug, K. J. AU - Brooks, D. M. AU - Chesebro, B. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 23 SP - 10492 EP - 10495 SN - 0027-8424 AD - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19972001019. Publication Type: Journal Article. Language: English. Number of References: 65 ref. KW - acquired immune deficiency syndrome KW - animal models KW - disease course KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunotherapy KW - major histocompatibility complex KW - medical treatment KW - passive immunity KW - t lymphocytes KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - disease progression KW - histocompatibility complex KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death. AU - Kolesnitchenko, V. AU - Wahl, L. M. AU - Tian, H. AU - Sunila, I. AU - Tani, Y. AU - Hartmann, D. P. AU - Cossman, J. AU - Raffeld, M. AU - Orenstein, J. AU - Samelson, L. E. AU - Cohen, D. I. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 25 SP - 11889 EP - 11893 SN - 0027-8424 AD - Kolesnitchenko, V.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development. N1 - Accession Number: 19962003504. Publication Type: Journal Article. Language: English. KW - apoptosis KW - cell cycle KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - pathogenesis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003504&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element. AU - Nasioulas, G. AU - Hughes, S. H. AU - Felber, B. K. AU - Whitcomb, J. M. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1995/// VL - 92 IS - 25 SP - 11940 EP - 11944 SN - 0027-8424 AD - Nasioulas, G.: National Cancer Institute Frederick Cancer Research and Development Center, PO Box B, Building 539, Frederick< MD 21702-1201, USA. N1 - Accession Number: 19962003582. Publication Type: Journal Article. Language: English. Number of References: 74 ref. KW - gene expression KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Rev protein KW - Avian leukosis virus KW - Retroviridae KW - Alpharetrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - avian oncovirus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003582&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. AU - Rader, D. J. AU - Mann, W. A. AU - Cain, W. AU - Kraft, H. G. AU - Usher, D. AU - Zech, L. A. AU - Hoeg, J. M. AU - Davignon, J. AU - Lupien, P. AU - Grossman, M. AU - Wilson, J. M. AU - Brewer, H. B., Jr. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 95 IS - 3 SP - 1403 EP - 1408 SN - 0021-9738 AD - Rader, D. J.: Molecular Disease Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951413553. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Lipoprotein (a) (LP(a)) is an atherogenic lipoprotein which is similar in structure to LDL. The role of the LDL receptor in the catabolism of Lp(a) has been controversial. An investigation of the in vivo catabolism of Lp(a) and LDL in 5 unrelated patients with homozygous familial hypercholesterolemia (FH) with have little or no LDL receptor activity was made. Purified 125I-Lp(a) and 131I-LDL were simultaneously injected into the homozygous FH patients, their heterozygous FH parents when available and control subjects. The disappearance of plasma radioactivity was followed over time. As expected, the fractional catabolic rates (FCR) of 131I-LDL were markedly decreased in the homozygous FH patients (mean LDL FCR 0.190 day-1) and somewhat decreased in the heterozygous FH parents (mean LDL FCR 0.294 day-1). In contrast, the catabolism of 125I-Lp(a) was not significantly different in the homozygous FH patients (mean FCR 0.251 day-1), heterozygous FH parents (mean FCR 0.287 day-1). In summary, absence of a functional LDL receptor does not result in delayed catabolism of Lp(a), indicating that the LDL receptor is not a physiologically important route of Lp(a) catabolism in man. KW - atherosclerosis KW - cholesterol KW - hypercholesterolaemia KW - lipoproteins KW - low density lipoprotein KW - metabolism KW - receptors KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - hypercholesterinemia KW - hypercholesterolemia KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413553&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. AU - Fiorelli, V. AU - Gendelman, R. AU - Markham, P. D. AU - Ensoli, B. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 95 IS - 4 SP - 1723 EP - 1734 SN - 0021-9738 AD - Fiorelli, V.: Correspondence address: B. Ensoli, Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962001598. Publication Type: Journal Article. Language: English. Number of References: 79 ref. KW - acquired immune deficiency syndrome KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - pathogenesis KW - T lymphocytes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - endothelial cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001598&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Improving food frequency questionnaires: a qualitative approach using cognitive interviewing. AU - Subar, A. F. AU - Thompson, F. E. AU - Smith, A. F. AU - Jobe, J. B. AU - Ziegler, R. G. AU - Potischman, N. AU - Schatzkin, A. AU - Hartman, A. AU - Swanson, C. AU - Kruse, L. AU - Hayes, R. B. AU - Lewis, D. R. AU - Harlan, L. C. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1995/// VL - 95 IS - 7 SP - 781 EP - 788 SN - 0002-8223 AD - Subar, A. F.: National Cancer Institute, Division of Cancer Prevention and Control, EPN 313, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19951410376. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - In an attempt to improve data quality and ease of administration of standard self-administered food frequency questionnaires, various alternative approaches were tried for inquiring about frequency of consumption, portion size, seasonal intake and food preparation. Evaluation consisted of a cognitive interviewing method in which respondents verbalize their thought process while completing several variations of a questionnaire. Interviewers observed and asked follow-up probe questions to evaluate problems or inconsistencies verbalized by respondents. Consensus and judgement by interviewers and observers suggested several problematic features of food frequency questionnaires: formatting of questions about frequency and portion size; computing average frequencies for aggregated food items or for foods eaten seasonally; comprehension of many items; and ordering of foods. These findings led to cognitive refinement and innovations, which included detailed questions regarding preparation or use of low-fat varieties or other alternatives to help better describe specifics of intake for some foods; questions on seasonal intake for several foods; inclusion of portion size ranges; and additional response categories for frequency of intake. Cognitive interviewing is an important step in pinpointing cognitive problems in dietary questionnaires. KW - diet KW - diet studies KW - diet study techniques KW - questionnaires KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410376&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trends in use of vitamin and mineral supplements in the United States: the 1987 and 1992 National Health Interview Surveys. AU - Slesinski, M. J. AU - Subar, A. F. AU - Kahle, L. L. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1995/// VL - 95 IS - 8 SP - 921 EP - 923 SN - 0002-8223 AD - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 313, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19951411794. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition KW - adults KW - diet studies KW - mineral supplements KW - minerals KW - vitamin supplements KW - vitamins KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411794&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy. AU - Sinnwell, T. M. AU - Sivakumar, K. AU - Soueidan, S. AU - Jay, C. AU - Frank, J. A. AU - McLaughlin, A. C. AU - Dalakas, M. C. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 96 IS - 1 SP - 126 EP - 131 SN - 0021-9738 AD - Sinnwell, T. M.: Correspondence address: M. C. Dalakas, Building 10, Room 4N248, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001613. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 30516-87-1. KW - adverse effects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - medical treatment KW - metabolism KW - muscles KW - muscular diseases KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AZT KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - myopathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001613&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Linkage between obesity and a marker near the tumor necrosis factor-α locus in Pima Indians. AU - Norman, R. A. AU - Bogardus, C. AU - Ravussin, E. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 96 IS - 1 SP - 158 EP - 162 SN - 0021-9738 AD - Norman, R. A.: National Institutes of Health, 4214 N, 16th Street, Phoenix, AZ 85016-5319, USA. N1 - Accession Number: 19951412516. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 308079-78-9. Subject Subsets: Human Nutrition N2 - Pima Indians were scored for genotypes at 3 polymorphic dinucleotide repeat loci (markers) near the gene tumour necrosis factor-α (TNF-α) at 6p21,3. In a sibling-pair linkage analysis, percent body fat, as measured by hydrostatic weighing, was linked to the marker closest to TNF-α. The same marker was associated by analysis of variance with body mass index (BMI). To search for possible DNA variants in TNF-α that contribute to obesity, single stranded conformational polymorphism analysis was performed for 20 obese and 20 lean subjects. Primer pairs were designed for the entire TNF-α protein coding region and part of the promoter. Only a single polymorphism located in the promoter region was detected. No association could be demonstrated between alleles at this polymorphism and percent body fat. It is concluded that the linkage of TNF-α to obesity may be due to a sequence variant undetected in TNF-α or due to a variant in some other closely linked gene. KW - diabetes KW - ethnic groups KW - genetics KW - linkage KW - obesity KW - tumour necrosis factor KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cachectin KW - cachexin KW - fatness KW - tumor necrosis factor KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412516&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro. AU - McNeely, T. B. AU - Dealy, M. AU - Dripps, D. J. AU - Orenstein, J. M. AU - Eisenberg, S. P. AU - Wahl, S. M. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 96 IS - 1 SP - 456 EP - 464 SN - 0021-9738 AD - McNeely, T. B.: Building 30, Room 329, National Institute of Dental Research, National Institutes of Health, 30 Convent Drive, MSC 4352, Bethesda, MD 20892-4352, USA. N1 - Accession Number: 19962001614. Publication Type: Journal Article. Language: English. Number of References: 55 ref. KW - antiviral agents KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - proteinase inhibitors KW - proteins KW - saliva KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - protease inhibitors KW - salivary secretions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001614&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation. AU - Kadiiska, M. B. AU - Burkitt, M. J. AU - Xiang, Q. H. AU - Mason, R. P. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1995/// VL - 96 IS - 3 SP - 1653 EP - 1657 SN - 0021-9738 AD - Kadiiska, M. B.: National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. N1 - Accession Number: 19951412078. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - Electron spin resonance (ESR) spectroscopy was used to investigate hydroxyl radical generation in Sprague-Dawley rats with chronic dietary iron loading. A secondary radical spin-trapping technique was used where hydroxyl radicals form methyl radicals upon reaction with dimethyl sulfoxide (DMSO). The methyl radical was then detected by ESR spectroscopy as its adduct with the spin trap α-phenyl-N-t-butylnitrone (PBN). This adduct was detected in the bile of rats 10 weeks after being given an iron-loading diet and 40 min after the intraperitoneal injection of the spin trap PBN dissolved in DMSO. Bile samples were collected into a solution of the ferrous stabilizing chelator 2,2′-dipyridyl in order to prevent the generation of radical adducts ex vivo during bile collection. Identification of the ESR spectrum of the major radical adduct as that of PBN/CH3 provides evidence for the generation of the hydroxyl radical during iron supplementation. Desferal completely inhibited in vivo hydroxyl radical generation stimulated by high dietary iron intake. No radical adducts were detected in rats which were given the control diet for the same period of time. This is the first evidence of hydroxyl radical generation in chronic iron-loaded rats. KW - free radicals KW - intake KW - iron KW - minerals KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum D-arabinitol. AU - Walsh, T. J. AU - Merz, W. G. AU - Lee, J. W. AU - Schaufele, R. AU - Sein, T. AU - Whitcomb, P. O. AU - Ruddel, M. AU - Burns, W. AU - Wingard, J. R. AU - Switchenko, A. C. AU - Goodman, T. AU - Pizzo, P. A. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1995/// VL - 99 IS - 2 SP - 164 EP - 172 SN - 0002-9343 AD - Walsh, T. J.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19951203069. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 2152-56-9. Subject Subsets: Medical & Veterinary Mycology N2 - A rapid automated enzymatic assay was used to investigate serum D-arabinitol (DA) in a large population of high-risk patients to determine its potential diagnostic, therapeutic and prognostic significance in invasive Candida infection. A total of 3223 serum samples were collected from 274 cancer patients at 2 oncology centres in the USA. Serum DA concn were determined in coded serum samples analysed by rapid enzymatic assay. Creatinine was also analysed in the same system to determine a serum DA and creatinine ratio (DA/Cr). The sensitivity, specificity, correlation with therapeutic response and prognostic significance were analysed for all patient study groups. Infections were due to C. albicans, C. tropicalis, Torulopsis glabrata, C. parapsilosis, C. krusei, C. lusitaniae and C. guilliermondii. A DA/Cr of ≥4.0 µmol/litre per mg/dl was detected in 31 of 42 cases (74%) of fungaemia and 25 of 30 cases (83%) of the subset of persistent fungaemia. Elevated DA/Cr was detected in 4 of 10 patients (40%) with tissue-proven, deeply invasive candidosis and negative blood cultures and 7 of 16 cases (44%) of deep mucosal candidosis. Elevated serial DA/Cr levels also were detected in persistently febrile and granulocytopenic patients requiring empirical amphotericin B. Among 26 assessable cases of fungaemia, abnormally elevated DA/Cr values were detected in 14 (54%) before, 10 (38%) after and 2 (8%) simultaneously with the first microbiological report of fungaemia. The trends of serial DA/Cr values correlated with therapeutic response in 29 (85%) of 34 patients with assessable cases of fungaemia, decreasing in 8 of 9 patients (89%) with clearance of fungaemia and increasing in 21 of 25 patients (84%) with persistence of fungaemia. Among the 34 assessable patients with fungaemia, mortality was directly related to the trend of serial DA/Cr determinations over time: 71% among fungaemic patients with persistently elevated or increasing DA/Cr, and 18% among the fungaemic patients with resolving DA/Cr or who never had elevated DA/Cr (P<0.01). Rapid enzymatic detection of DA in serially collected serum samples from high-risk cancer patients permitted detection of invasive candidosis, early recognition of fungaemia and therapeutic monitoring in DA-positive cases. It is concluded that serially collected serum DA determinations complement blood cultures for improving detection and monitoring therapeutic response in patients at risk for invasive candidosis. KW - arabinitol KW - candidosis KW - diagnosis KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - neoplasms KW - opportunistic infections KW - predisposition KW - serology KW - serum KW - USA KW - Blastodendrion arztii KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida lusitaniae KW - Candida parapsilosis KW - Candida tropicalis KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - Pezizomycotina KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Blastodendrion KW - cancers KW - Candida guilliermondii KW - Candida krusei KW - candidiasis KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951203069&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The treatment of aids and cancer in the third millennium. AU - Gallo, R. C. AU - Montagnier, J. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1995/// VL - 99 IS - Sup6A SP - 6S EP - 10S SN - 0002-9343 AD - Gallo, R. C.: Laboratory of Tumor Cell Biology, Building 37, Room 6A09, National Cancer Institute, 37 Convent Drive, MSC-4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962003772. Publication Type: Journal Article. Language: English. KW - acquired immune deficiency syndrome KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - medical treatment KW - molecular biology KW - neoplasms KW - pathogenesis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cancers KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003772&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Assessment of suitability & ease of performance of seven commercial assay systems for the detection of antibodies to HIV-1. AU - Sreedharan, A. AU - Jayshree, R. S. AU - Anita Desai AU - Hema Sridhar AU - Chandramuki, A. AU - Ravi, V. JO - Indian Journal of Medical Research JF - Indian Journal of Medical Research Y1 - 1995/// VL - 101 IS - MAY SP - 179 EP - 182 AD - Sreedharan, A.: Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India. N1 - Accession Number: 19952004926. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Tropical Diseases N2 - In this study, the authors have evaluated the suitability and ease of performance of 7 HIV assays namely: Vironostika anti-HIV Uni-Form; Vironostika HIV MIXT; Elavia MIXT; Genelavia MIXT; Serodia-HIV; Immunocomb Bi-spot; and Test pack HIV-1 and 2 Abbott, for use in Indian laboratories. A panel of 41 blind coded Western blot confirmed sera were used for this purpose. Rapid assays like Immunocomb Bi-Spot, Serodia HIV and Test pack HIV-1/HIV-2 Abbott were found to be more suitable and easy to perform as compared to the ELISAs. Sensitivity of all the assays was excellent (100%). Specificity of Serodia HIV, Immunocomb Bi-spot, Test pack HIV-1 and 2 Abbott and Elavia MIXT were excellent (100%), while that of Vironostika MIXT and Vironostika anti-HIV Uni-Form was poor. Positive predictive value of the assays ranged from 64.5 to 100%. Negative predictive value of 6 of the assays was 100% and that of Vironostika anti-HIV Uni-Form was very poor. KW - antibodies KW - assessment KW - comparisons KW - detection KW - diagnosis KW - human diseases KW - human immunodeficiency viruses KW - performance KW - systems KW - Asia KW - India KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004926&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathological lesions in HIV positive patients. AU - Santosh, V. AU - Shankar, S. K. AU - Das, S. AU - Pal, L. AU - Ravi, V. AU - Desai, A. AU - Sreedharan, A. AU - Khanna, N. AU - Chandramuki, A. AU - Satishchandra, P. AU - Swamy, H. S. AU - Nagaraj, D. AU - Gourie-Devi, M. AU - Das, B. S. JO - Indian Journal of Medical Research JF - Indian Journal of Medical Research Y1 - 1995/// VL - 101 IS - APRIL SP - 134 EP - 141 AD - Santosh, V.: Department of Neuropathology, National Institute of Mental Health & Neuro Sciences, Bangalore, India. N1 - Accession Number: 19952004853. Publication Type: Journal Article. Language: English. Number of References: 22 ref. KW - central nervous system KW - encephalitis KW - human diseases KW - human immunodeficiency viruses KW - lesions KW - meningitis KW - patients KW - postmortem examinations KW - tuberculosis KW - India KW - acanthamoeba KW - Toxoplasma KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - autopsy KW - CNS KW - encephalomyelitis KW - human immunodeficiency virus KW - postmortem inspections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004853&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progress in AIDS vaccine development. AU - Johnston, M. I. JO - International Archives of Allergy and Immunology JF - International Archives of Allergy and Immunology Y1 - 1995/// VL - 108 IS - 4 SP - 313 EP - 317 SN - 1018-2438 AD - Johnston, M. I.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7620, USA. N1 - Accession Number: 19962004644. Publication Type: Journal Article. Language: English. Number of References: 29 ref. KW - acquired immune deficiency syndrome KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - vaccine development KW - vaccines KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004644&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasitic infection in malnourished school children: effects on behaviour and EEG. AU - Levav, M. AU - Mirsky, A. F. AU - Schantz, P. M. AU - Casro, S. AU - Cruz, M. E. JO - Parasitology JF - Parasitology Y1 - 1995/// VL - 110 IS - 1 SP - 103 EP - 111 SN - 0031-1820 AD - Levav, M.: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892-1366, USA. N1 - Accession Number: 19950801866. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology; Helminthology; Tropical Diseases N2 - A study of 194 children (9-13) from a mountain village in Ecuador who were infected with one or more species of intestinal helminth or protozoan parasite is described. In addition to parasite load, the assessment consisted of a battery of psychological and neuropsychological tests, an EEG examination, measures of iodine level, presence of goitre and level of nutrition. It was found that, in general, parasite infection, as measured at the baseline level, was not associated with cognitive impairment. The intensity of infection with Ascatis lumbricoides, however, was correlated with the level of verbal ability and with inhibition-control aspects of cognitive behaviour. Multivariate analysis with level of nutrition, EEG status and parasite burden showed a consistent main effect of the degree of nutrition on neuropsychological performance, particularly the language, problem solving and inhibition-control dimensions. KW - behaviour KW - children KW - electroencephalography KW - epidemiology KW - helminths KW - infection KW - malnutrition KW - neurophysiology KW - parasites KW - parasitoses KW - pathology KW - school children KW - Ecuador KW - South America KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - behavior KW - EEG KW - parasitic diseases KW - parasitic infestations KW - parasitic worms KW - parasitosis KW - school kids KW - schoolchildren KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801866&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changes in lipophosphoglycan and gene expression associated with the development of Leishmania major in Phlebotomus papatasi. AU - Saraiva, E. M. B. AU - Pimenta, P. F. P. AU - Brodin, T. N. AU - Rowton, E. AU - Modi, G. B. AU - Sacks, D. L. JO - Parasitology JF - Parasitology Y1 - 1995/// VL - 111 IS - 3 SP - 275 EP - 287 SN - 0031-1820 AD - Saraiva, E. M. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950808325. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Stage-specific molecular and morphogenic markers were used to follow the kinetics of appearance, number and position of metacyclic promastigotes developing during the course of Leishmania major infection in Phlebotomus papatasi. Expression of surface lipophosphoglycan (LPG) on transformed promastigotes was delayed until the appearance of nectomonad forms on day 3 and continued to be abundantly expressed by all promastigotes thereafter. An epitope associate with arabinose substitution of LPG side-chain oligosaccharides, identified by its differential expression by metacyclics in vitro, was detected on the surface of a low proportion of midgut promastigotes beginning on day 5 and on up to 60% of promastigotes on days 10 and 15. In contrast, 100% of the parasites egested from the mouthparts during forced feeding of 15 day infected flies stained strongly for this epitope. At each time-point, the surface expression of the modified LPG was restricted to morphologically distinguished metacyclic forms. Ultrastructural study of the metacyclic surface revealed an approximate 2-fold increase in the thickness of the surface coat compared to nectomonad forms, suggesting elongation of LPG as occurs during metacyclogenesis in vitro. A metacyclic-associated transcript (MAT-1), another marker identified by its differential expression in vitro, also showed selective expression by promastigotes in the fly, and was used in in situ hybridization studies to demonstrate the positioning of metacyclics in the anterior gut. KW - development KW - disease vectors KW - experimental infections KW - gene expression KW - intermediate hosts KW - laboratory animals KW - life history KW - lipophosphoglycans KW - molecular biology KW - molecular genetics KW - parasites KW - Diptera KW - Leishmania major KW - Phlebotominae KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - biochemical genetics KW - secondary hosts KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ribavirin as therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. AU - Bisceglie, A. M. di AU - Conjeevaram, H. S. AU - Fried, M. W. AU - Sallie, R. AU - Park, Y. AU - Yurdaydin, C. AU - Swain, M. AU - Kleiner, D. E. AU - Mahaney, K. AU - Hoofnagle, J. H. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1995/// VL - 123 IS - 12 SP - 897 EP - 903 SN - 0003-4819 AD - Bisceglie, A. M. di: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19962005625. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 36791-04-5. Subject Subsets: Public Health N2 - The authors evaluated ribavirin as therapy for chronic hepatitis C in a randomized, double-blind, placebo-controlled study at a tertiary referral research hospital in Maryland, USA. 29 patients with chronic hepatitis C who received oral ribavirin (600 mg twice daily) for 12 months and 29 controls with chronic hepatitis C who received placebo for 12 months were studied. Effects of therapy were evaluated by measuring serum aminotransferase activity and hepatitis C virus (HCV) RNA levels before, during, and for 6 months after therapy and by histological examination of liver specimens before and at the end of treatment. Patients treated with ribavirin had a prompt decrease in serum aminotransferase activity (54% overall) compared with activity before treatment and activity in controls (5% decrease). Serum aminotransferase levels became normal or nearly normal in 10 patients treated with ribavirin (35% [95% CI, 18% to 54%]) but in no controls (0% [CI, 0% to 12%]). Aminotransferase activity remained normal in only 2 patients after ribavirin therapy was discontinued (7% [CI, 1% to 23%]). Serum HCV RNA activity did not change during or after therapy. Liver biopsy specimens showed a decrease in hepatic inflammation and necrosis among ribavirin-treated patients whose aminotransferase activity became normal. The authors conclude that ribavirin has beneficial effects on serum aminotransferase activity and histological findings in the liver in patients with chronic hepatitis C, but these effects are not accompanied by changes in HCV RNA levels and are not sustained when ribavirin therapy is discontinued. Thus, ribavirin alone for periods as long as 12 months is unlikely to be of value as therapy for chronic hepatitis C. KW - chronic infections KW - drug therapy KW - hepatitis C KW - human diseases KW - ribavirin KW - Maryland KW - North America KW - USA KW - hepatitis C virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - tribavirin KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005625&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta). AU - Lane, M. A. AU - Reznick, A. Z. AU - Tilmont, E. M. AU - Lanir, A. AU - Ball, S. S. AU - Read, V. AU - Ingram, D. K. AU - Cutler, R. G. AU - Roth, G. S. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1995/// VL - 125 IS - 6 SP - 1600 EP - 1610 SN - 0022-3166 AD - Lane, M. A.: Molecular Physiology and Genetics Section, Nathan Shock Laboratories, Gerontology Research Center, National Institute on Aging, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA. N1 - Accession Number: 19951411232. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - The effects of aging and long-term (>6.0 years) food restriction on several indices of bone growth and metabolism were studied in rhesus monkeys (Macaca mulatta). Food allotments for controls approximated free access consumption, whereas food-restricted monkeys received 30% less food on a body weight basis. Cross-sectional and longitudinal age effects on serum alkaline phosphatase paralleled those reported for man. Food restriction induced a significant delay in the developmental decline (to adult levels) in total alkaline phosphatase and significantly suppressed serum interleukin 6 concentrations, particularly in younger monkeys. Also, food restriction slowed skeletal growth, as reflected by shorter crown-rump length, and significantly reduced total body bone mineral content, but not bone mineral density, measured by dual energy X-ray absorptiometry. Analyses of serum parathyroid hormone, calcium phosphate and osteocalcin concentrations suggested that the effects on skeletal growth were not related to alterations in Ca in bone formation. These findings suggest that long-term food restriction delays skeletal development in male rhesus monkeys while allowing the development of a reduced but otherwise normal skeleton. KW - aging KW - bone density KW - bones KW - metabolism KW - mineral content KW - restricted feeding KW - macaca mulatta KW - monkeys KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantification and localization of phosphorylated myosin I isoforms in Acanthamoeba castellanii. AU - Baines, I. C. AU - Corigliano-Murphy, A. AU - Korn, E. D. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1995/// VL - 130 IS - 3 SP - 591 EP - 603 SN - 0021-9525 AD - Baines, I. C.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19960803571. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9064-37-3. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activities of the 3 myosin I isoforms in Acanthamoeba castellanii were significantly expressed only after phosphorylation of a single site in the myosin I heavy chain. Synthetic phosphorylated and unphosphorylated peptides corresponding to the phosphorylation site sequences, which differ for each myosin I isoform, were used to raise isoform-specific antibodies that recognized only the phosphorylated myosin I or the total myosin I isoform (phosphorylated and unphosphorylated), respectively. With these antisera, the amounts of total and phosphorylated isoform were quantified, the phosphomyosin I isoforms were localized and the compartmental distribution of the phosphomyosin isoforms was determined. Myosin IA, which was almost entirely in the actin-rich cortex, was 70-100% phosphorylated and particularly enriched under phagocytic cups. Myosins IB and IC were predominantly associated with plasma membranes and large vacuole membranes, where they were only 10-20% phosphorylated. Cytoplasmic myosins IB and IC, like cytoplasmic myosin IA, were mostly phosphorylated (60-100%). Phosphomyosin IB was concentrated in actively motile regions of the plasma membrane. More than 20-fold more phosphomyosin IC and 10-fold more F-actin were associated with the membranes of contracting contractile vacuoles (CV) than of filling CVs. The total amount of CV-associated myosin IC remained constant, suggesting that it is phosphorylated at the start of CV contraction. The data support previous proposals that phosphomyosin IA is involved in phagocytosis, phosphomyosin IB is involved in phagocytosis and pinocytosis, and phosphomyosin IC is involved in CV contraction. KW - actin KW - antibodies KW - cell membranes KW - cytochemistry KW - cytoplasm KW - isoenzymes KW - localization KW - myosins KW - parasites KW - peptides KW - phagocytosis KW - phosphorylation KW - plasma membranes KW - vacuoles KW - Acanthamoeba castellanii KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cell membrane KW - isozymes KW - myosin KW - plasmalemma KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803571&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Eosinophilic folliculitis associated with the acquired immunodeficiency syndrome responds well to permethrin. AU - Blauvelt, A. AU - Plott, R. T. AU - Spooner, K. AU - Stearn, B. AU - Davey, R. T. AU - Turner, M. L. T2 - Archives of Dermatology JO - Archives of Dermatology JF - Archives of Dermatology Y1 - 1995/// VL - 131 IS - 3 SP - 360 EP - 361 SN - 0003-987X AD - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008269. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 52645-53-1. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - insecticides KW - permethrin KW - skin diseases KW - treatment KW - Demodex folliculorum KW - man KW - mites KW - Demodex KW - Demodicidae KW - Prostigmata KW - mites KW - Acari KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - AIDS KW - dermatoses KW - eosinophilic folliculitis KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008269&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - BK virus and a new type of JC virus excreted by HIV-1 positive patients in rural Tanzania. AU - Agostini, H. T. AU - Brubaker, G. R. AU - Shao, J. AU - Levin, A. AU - Ryschkewitsch, C. F. AU - Blattner, W. A. AU - Stoner, G. L. JO - Archives of Virology JF - Archives of Virology Y1 - 1995/// VL - 140 IS - 11 SP - 1919 EP - 1934 SN - 0304-8608 AD - Agostini, H. T.: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA. N1 - Accession Number: 19962002524. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Tropical Diseases N2 - HIV-1 positive patients from villages near Shirati, Tanzania were examined for urinary excretion of the human polyomaviruses JC and BK using the polymerase chain reaction (PCR). BK virus (BKV) was detected in 11 of 23 individuals tested. The BKV DNA sequences were all closely related to prototype Gardner strain and BKV (DUN). In contrast, a new type of JCV, termed Type 3 [or JCV (Shi)], was identified in 7 of these same 23 individuals by comparison with Type 1 and Type 2 sequences of the VP1/intergenic/T antigen region of USA, European and Asian strains. This suggests that JCV and BKV, although closely related, have different evolutionary histories within the African population. The 6 BKV regulatory regions amplified all showed the archetypal configuration. However, two of the 7 JCV regulatory regions showed rearrangements: a small deletion and an inverted repeat. JCV causes a fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML), in about 5% of AIDS patients in Europe and the USA, but only one case has been reported in Africa. The authors' results suggest that this rarity of PML is not due to the absence of JCV in the African population. KW - disease prevalence KW - epidemiology KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - infections KW - rural areas KW - rural communities KW - Africa KW - Tanzania KW - BK polyomavirus KW - JC polyomavirus KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - jc virus KW - polyomavirus hominis 1 KW - Tanganyika KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002524&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does weight loss from middle age to old age explain the inverse weight mortality relation in old age? AU - Losonczy, K. G. AU - Harris, T. B. AU - Cornoni-Huntley, J. AU - Simonsick, E. M. AU - Wallace, R. B. AU - Cook, N. R. AU - Ostfeld, A. M. AU - Blazer, D. G. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 141 IS - 4 SP - 312 EP - 321 SN - 0002-9262 AD - Losonczy, K. G.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892-9205, USA. N1 - Accession Number: 19951404930. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - Body mass index at middle age, body mass index in old age, and weight change between 50 years and old age were examined in relation to mortality in old age. The study population from the Established Populations for Epidemiologic Studies of the Elderly consisted of 6387 white subjects 70 years or older who experienced 2650 deaths during the period 1982-1987. Mortality risk was highest for persons in the heaviest quintile of body mass index at age 50 (men, relative risk (RR) 1.33, 95% confidence interval (CI) 1.13-1.57; women, RR 1.31, 95% CI 1.12-1.53) compared with persons in the middle quintile. This pattern was reversed for body mass index in old age, the persons in the lowest quintile having the highest mortality risk (men, RR 1.40, 95% CI 1.19-1.65; women, RR 1.38, 95% CI 1.17-1.63) relative to persons in the middle quintile. This reversal was explained in part by weight change. Compared with persons with stable weight, those who lost 10% or more body weight between age 50 and old age had the highest risk of mortality (men, RR 1.69, 95% CI 1.45-1.97; women, RR 1.62, 95% CI 1.38-1.90). Exclusion of participants who lost 10% or more of their weight and adjustment for health status eliminated the higher risk of death associated with low weight. The inverse association of weight and mortality in old age appears to reflect illness related weight loss from heavier weight in middle age. Weight history may be critical to understanding weight and mortality relations in old age. KW - aging KW - body weight KW - middle age KW - mortality KW - old age KW - weight losses KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - death rate KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951404930&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nitrous oxide and spontaneous abortion in female dental assistants. AU - Rowland, A. S. AU - Baird, D. D. AU - Shore, D. L. AU - Weinberg, C. R. AU - Savitz, D. A. AU - Wilcox, A. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 141 IS - 6 SP - 531 EP - 538 SN - 0002-9262 AD - Rowland, A. S.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19952003988. Publication Type: Journal Article. Language: English. Registry Number: 10024-97-2. Subject Subsets: Public Health N2 - Questionnaires were sent to 7000 dental assistants aged 18-39 years who were registered in California in 1987; 4,856 (69%) responded. Analysis was based on 1,465 respondents whose most recent pregnancy was conceived while working full time. Women were asked how many hours a week they worked with nitrous oxide during this pregnancy and whether the excess gas was scavenged (vented). Relative risk of spontaneous abortion (through week 20) was calculated using a person-week model. This allowed women with current pregnancies (13%) or induced abortions (10%) to be included for appropriate time periods of risk. A total of 101 pregnancies (7%) ended as spontaneous abortions. An elevation in risk of spontaneous abortion was seen among women who worked with nitrous oxide for 3 or more hours per week in offices not using scavenging equipment (relative risk = 2.6, 95% confidence interval 1.3-5.0, adjusted for age, smoking, and number of amalgams prepared per week), but not among those using nitrous oxide in offices with scavenging equipment. This relation changed little when analyses were restricted to confirmed pregnancies or examined for several types of potential bias. Scavenging equipment appears to be important in protecting the reproductive health of women working with nitrous oxide. KW - abortion KW - air pollutants KW - dentistry KW - nitrous oxide KW - occupational hazards KW - occupations KW - spontaneous abortion KW - women KW - California KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - dental assistants KW - miscarriage KW - United States of America KW - Occupational Health and Safety (VV900) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003988&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prognostic factors for all-cause mortality among hemophiliacs infected with human immunodeficiency virus. AU - Diamondstone, L. S. AU - Blakley, S. A. AU - Rice, J. C. AU - Clark, R. A. AU - Goedert, J. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 142 IS - 3 SP - 304 EP - 313 SN - 0002-9262 AD - Diamondstone, L. S.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19962007074. Publication Type: Journal Article. Language: English. Number of References: 46 ref. KW - acquired immune deficiency syndrome KW - haemophilia KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - mortality KW - prognosis KW - risk groups KW - USA KW - hepatitis c virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - death rate KW - hemophilia KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007074&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Colon cancer and serum vitamin D metabolite levels 10-17 years prior to diagnosis. AU - Braun, M. M. AU - Helzlsouer, K. J. AU - Hollis, B. W. AU - Comstock, G. W. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 142 IS - 6 SP - 608 EP - 611 SN - 0002-9262 AD - Braun, M. M.: Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19961407600. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 32222-06-3, 1406-16-2. Subject Subsets: Human Nutrition N2 - This study examines the hypothesis that low serum levels of vitamin D metabolites are associated with an increased risk for colon cancer. From August through November 1974, 20 305 residents of Washington County, Maryland, USA donated blood for storage at -70°C in a serum bank. Colon cancer was subsequently diagnosed among 57 of these residents during 1984-1991. Controls had donated blood in 1974 and remained free of colon cancer through the date of diagnosis of the case. 2 controls were matched to each case on age (±1 year), race, sex and date of blood draw (±1 month). Mean 25-hydroxyvitamin D levels were 23.6 and 23.2 ng/ml, and mean calcitriol levels were 34.7 and 34.6 pg/ml, in cases and controls, respectively. Analysis by quintile of serum level similarly found that none of the 95% confidence intervals of the odds ratios excluded unity, and a dose-response effect was not observed. The data provide no strong support for the hypothesis that vitamin D metabolite levels affect the subsequent risk for colon cancer. KW - blood KW - calcitriol KW - colon KW - neoplasms KW - vitamin D KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - cancers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407600&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of secular trends in CD4+ lymphocyte loss among human immunodeficiency virus type 1 (HIV-1)-infected men with known dates of seroconversion. AU - O'Brien, T. R. AU - Hoover, D. R. AU - Rosenberg, P. S. AU - Chen, B. AU - Detels, R. AU - Kingsley, L. A. AU - Phair, J. AU - Saah, A. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 142 IS - 6 SP - 636 EP - 642 SN - 0002-9262 AD - O'Brien, T. R.: Epidemiology and Biostatistics Program, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA. N1 - Accession Number: 19962006265. Publication Type: Journal Article. Language: English. Number of References: 23 ref. KW - disease course KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - men KW - seroconversion KW - serology KW - t lymphocytes KW - trends KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006265&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica. AU - Krämer, A. AU - Maloney, E. M. AU - Morgan, O. S. C. AU - Rodgers-Johnson, P. AU - Manns, A. AU - Murphy, E. L. AU - Larsen, S. AU - Cranston, B. AU - Murphy, J. AU - Benichou, J. AU - Blattner, W. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1995/// VL - 142 IS - 11 SP - 1212 EP - 1220 SN - 0002-9262 AD - Krämer, A.: Viral Epidemiology Branch, National Cancer Institute, EPN Room 434, Rockville, MD, USA. N1 - Accession Number: 19962007347. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Tropical Diseases N2 - Human T-cell lymphotropic virus type I (HTLV-I) has been aetiologically associated with a neurological syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as well as with adult T-cell leukaemia/lymphoma. This study sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals. Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurological diseases were enrolled in a retrospective study. A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with 2 (4.0%) of the controls with other neurological diseases. Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio = 4.00, 95% confidence interval 1.29-12.46 for individuals aged ≤15; odds ratio = 4.26, 95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse). Among individuals who reported this early age at initial sexual intercourse, an increased risk of HAM/TSP was associated with having reported more than 5 lifetime sexual partners (odds ratio = 2.88, 95% confidence interval 0.90-8.70). Neither an early age at initial sexual intercourse nor the number of lifetime sexual partners was a risk factor for adult T-cell leukaemia/lymphoma. These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukaemia/lymphoma is not. KW - epidemiology KW - human diseases KW - infections KW - myelopathy KW - risk factors KW - sexual partners KW - sexually transmitted diseases KW - viral diseases KW - Caribbean KW - Jamaica KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - man KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - sexually transmitted infections KW - STDs KW - venereal diseases KW - viral infections KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007347&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of IL-12 in HIV disease/AIDS. AU - Chougnet, C. AU - Clerici, M. AU - Shearer, G. M. JO - Research in Immunology JF - Research in Immunology Y1 - 1995/// VL - 146 IS - 7-8 SP - 615 EP - 619 SN - 0923-2494 AD - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19962008883. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - acquired immune deficiency syndrome KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunological deficiency KW - immunology KW - interleukins KW - pathogenesis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune deficiency KW - immunodeficiency KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008883&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of IL12 induction of cell-mediated immunity to Toxoplasma gondii. AU - Scharton-Kersten, T. AU - Denkers, E. Y. AU - Gazzinelli, R. AU - Sher, A. JO - Research in Immunology JF - Research in Immunology Y1 - 1995/// VL - 146 IS - 7/8 SP - 539 EP - 545 SN - 0923-2494 AD - Scharton-Kersten, T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960805348. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - The role of interleukin (IL)-12 in establishing the host immune response to Toxoplasma gondii is reviewed, with reference to interferon (IFN)-γ-dependent cell mediated immunity, the role of IL-12 in the initiation of the innate IFN-γ response, the role of IL-12 in adaptive immunity, and control of IL-12 function during infection. Studies have shown that T. gondii is a potent, IFN-γ-independent stimulus of controlled IL-12 production and, as a result, an effective stimulator of protective cell-mediated immunity. KW - cell mediated immunity KW - immune response KW - immunology KW - interferon KW - interleukin 12 KW - parasites KW - reviews KW - toxoplasmosis KW - protozoa KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cellular immunity KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805348&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes. AU - Wynn, T. A. AU - Sher, A. JO - Research in Immunology JF - Research in Immunology Y1 - 1995/// VL - 146 IS - 7/8 SP - 582 EP - 590 SN - 0923-2494 AD - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960805354. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - The potential of interleukin (IL)-12 as an adjuvant for vaccines designed to reduce infection and prevent the pathology associated with schistosome infection is reviewed, with reference to the enhancement of vaccine-induced immunity to Schistosoma mansoni by IL-12, the effects of IL-12 in other helminth infections, the role of endogenous and exogenous IL-12 in the regulation of schistosome egg granuloma formation, the role of interferon-γ in IL-12-mediated immunoregulation, the partial suppression of established Th2 responses and marked decrease of secondary granulomatous inflammation by IL-12, and the adjuvant activity of IL-12 in an anti-pathology vaccine for schistosomiasis. The data show that IL-12 can upregulate protective immunity against schistosomes in the attenuated vaccine model and can act as an adjuvant suppressing both granuloma formation and fibrosis induced by natural infection. KW - adjuvants KW - animal models KW - attenuation KW - fibrosis KW - granuloma KW - helminths KW - human diseases KW - immunity KW - immunization KW - inflammation KW - interferon KW - interleukin 12 KW - parasites KW - pathology KW - reviews KW - schistosomiasis KW - T lymphocytes KW - vaccine development KW - vaccines KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - bilharzia KW - bilharziasis KW - immune sensitization KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805354&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis. AU - Ognibene, F. P. AU - Shelhamer, J. H. AU - Hoffman, G. S. AU - Kerr, G. S. AU - Reda, D. AU - Fauci, A. S. AU - Leavitt, R. Y. JO - American Journal of Respiratory and Critical Care Medicine JF - American Journal of Respiratory and Critical Care Medicine Y1 - 1995/// VL - 151 IS - 3 Part 1 SP - 795 EP - 799 SN - 1073-449X AD - Ognibene, F. P.: Department of Critical Care Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1662, USA. N1 - Accession Number: 19961200244. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A retrospective analysis of all patients with a diagnosis of Wegener's granulomatosis and P. carinii pneumonia at the National Institute of Allergy and Infectious Diseases, Maryland, USA, was performed. The chart review focused on clinical, laboratory and roentgenological evidence of P. carinii pneumonia. 11 cases of P. carinii pneumonia were diagnosed in 180 patients with Wegener's granulomatosis, giving an overall incidence of approx. 6%. All patients developed P. carinii pneumonia either during the initial course of treatment or during therapy for recurrent Wegener's granulomatosis. All patients were receiving daily glucocorticoids and a 2nd immunosuppressive therapy. Lymphocytopenia was noted in all patients, with a mean ± SEM total lymphocyte count of 303±69 cells/µl. All patients tested (10 of 11) were seronegative for HIV infection. Eight patients presented with worsening chest roentgenograms compared with baseline, while 3 presented with normal chest roentgenograms. It is concluded that P. carinii is a common opportunistic pathogen in patients with Wegener's granulomatosis receiving immunosuppressive therapy. Therapeutic immunosuppression (daily glucocorticoids and immunosuppressive agents) and the resultant lymphocytopenia, as well as the lymphocyte and monocyte functional abnormalities caused by glucocorticoids, may be the most likely factors predisposing to P. carinii pneumonia in patients with Wegener's granulomatosis. It is recommended that all patients with Wegener's granulomatosis be given chemoprophylaxis against P. carinii while they are receiving daily glucocorticoids and that clinicians should evaluate these patients for P. carinii if there is even a minor clinical or roentgenographic change in their status. KW - acquired immune deficiency syndrome KW - hosts KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - infections KW - lungs KW - mycoses KW - opportunistic infections KW - pneumocystosis KW - pneumonia KW - predisposition KW - Maryland KW - USA KW - fungi KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - fungus KW - United States of America KW - Wegener's granulomatosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200244&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. AU - Berenguer, J. AU - Allende, M. C. AU - Lee, J. W. AU - Garrett, K. AU - Lyman, C. AU - Ali, N. M. AU - Bacher, J. AU - Pizzo, P. A. AU - Walsh, T. J. JO - American Journal of Respiratory and Critical Care Medicine JF - American Journal of Respiratory and Critical Care Medicine Y1 - 1995/// VL - 152 IS - 3 SP - 1079 EP - 1086 SN - 1073-449X AD - Berenguer, J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200016. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 59865-13-3. Subject Subsets: Medical & Veterinary Mycology N2 - To compare the pathogenesis of aspergillosis in patients with chemotherapy-induced granulocytopenia for neoplastic disorders and those receiving cyclosporin A plus corticosteroids for prevention and treatment of organ transplant rejection, and to further characterize the role of cyclosporin A in development of pulmonary aspergillosis, the patterns of infection and inflammation in 2 clinically applicable rabbit models of invasive pulmonary aspergillosis were studied. There were striking differences in the patterns of infection and inflammation of invasive pulmonary Aspergillus fumigatus infection according to the type of underlying immune defect. Among rabbits challenged with the same intratracheal inoculum, there was a 100% mortality for invasive pulmonary aspergillosis in profoundly granulocytopenic rabbits in comparison with a 100% survival in rabbits immunosuppressed with cyclosporin A plus methylprednisolone (CsA + MP). Lesions of pulmonary aspergillosis in granulocytopenic rabbits consisted predominantly of coagulative necrosis, intraalveolar haemorrhage and scant mononuclear inflammatory infiltrate. By comparison, pulmonary foci in rabbits immunosuppressed by CsA + MP consisted mainly of neutrophilic and monocytic infiltrates, inflammatory necrosis and scant intraalveolar haemorrhage. There was extensive infiltration by hyphae with angioinvasion in granulocytopenic rabbits, while conidia in various stages of germination predominated in CsA + MP-treated animals in which there was a paucity of hyphae or angioinvasion. Extrapulmonary disease predominated in granulocytopenic rabbits. Methylprednisolone was the major immunosuppressive drug in rabbits treated with CsA + MP. Cyclosporin A alone did not increase the progression of pulmonary aspergillosis and did so only when used chronically with methylprednisolone. KW - aspergillosis KW - ciclosporin KW - corticoids KW - experimental infections KW - immunocompromised hosts KW - infections KW - lungs KW - opportunistic infections KW - pathogenesis KW - predisposition KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - corticosteroids KW - cyclosporin KW - fungus KW - granulocytopenia KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200016&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule. AU - Takeshita, T. AU - Takahashi, H. AU - Kozlowski, S. AU - Ahlers, J. D. AU - Pendleton, C. D. AU - Moore, R. L. AU - Nakagawa, Y. AU - Yokomuro, K. AU - Fox, B. S. AU - Margulies, D. H. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 4 SP - 1973 EP - 1986 SN - 0022-1767 AD - Takeshita, T.: Correspondence address: J. A. Berzofsky, Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009467. Publication Type: Journal Article. Language: English. Number of References: 49 ref. KW - binding KW - conformation KW - human diseases KW - human immunodeficiency viruses KW - major histocompatibility complex KW - peptides KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - body conformation KW - histocompatibility complex KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines. AU - Kinter, A. L. AU - Poli, G. AU - Fox, L. AU - Hardy, E. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 5 SP - 2448 EP - 2459 SN - 0022-1767 AD - Kinter, A. L.: Building 10A, Room 6A33A, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009469. Publication Type: Journal Article. Language: English. Number of References: 74 ref. KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interleukins KW - phagocytes KW - replication KW - T lymphocytes KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009469&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. AU - Blauvelt, A. AU - Clerici, M. AU - Lucey, D. R. AU - Steinberg, S. M. AU - Yarchoan, R. AU - Walker, R. AU - Shearer, G. M. AU - Katz, S. I. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 7 SP - 3506 EP - 3515 SN - 0022-1767 AD - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Building 10/Room 12N238, 10 Center Dr., MSC 1908, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009056. Publication Type: Journal Article. Language: English. Number of References: 56 ref. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - monocytes KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Langerhans cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. AU - Samaniego, F. AU - Markham, P. D. AU - Gallo, R. C. AU - Ensoli, B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 7 SP - 3582 EP - 3592 SN - 0022-1767 AD - Samaniego, F.: Correspondence address: B. Ensoli, Laboratory of Tumor Cell Biology, Bldg. 37, Rm. 6A09, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952009058. Publication Type: Journal Article. Language: English. Number of References: 44 ref. KW - acquired immune deficiency syndrome KW - animal models KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - pathogenesis KW - man KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-β, which down-regulates macrophage antiparasitic activity. AU - Williams, M. E. AU - Casper, P. AU - Oswald, I. AU - Sharma, H. K. AU - Pankewycz, O. AU - Sher, A. AU - James, S. L. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 9 SP - 4693 EP - 4700 SN - 0022-1767 AD - Williams, M. E.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007714. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 76057-06-2. Subject Subsets: Tropical Diseases; Helminthology N2 - C57BL/6 mice immunized intradermally (i.d.) with bacillus Calmette Guerin (BCG) plus killed skin-stage schistosomula are protected against subsequent infection with Schistosoma mansoni, whereas immunization by i.v. or i.m. routes is not protective. Moreover, previous immunization via the nonprotective i.v. route interfered with the ability to subsequently induce protection by i.d. vaccination, suggesting that inhibitory responses are invoked. Given the evidence that activated macrophages (Mφ) play a role as effector cells in protection against schistosomiasis, the authors investigated the ability of spleen cells from protected and nonprotected immunized mice to produce Mφ activating and deactivating cytokines. Exposure to supernatant fluids (SNs) from Ag stimulated spleen cells of i.d., but not i.v. or i.m., immunized mice activated inflammatory Mφ for in vitro killing of schistosome larvae, through a mechanism dependent on both IFNγ and TNF-α. No evidence was observed for the preferential induction of the Mφ activating Th1 cytokines IFN-γ and IL-2 in i.d. immunized mice, nor did spleen cells from nonprotected animals produce higher levels of the Th2 associated cytokines IL-4 and IL-10, which are known to prevent Mφ activation. TGF-β was, however, detected in SNs from unprotected mice. Moreover, the Mφ inhibitory activity detected in these SNs was heat stable and neutralized by anti-TGF-β Abs, suggesting that production of transforming growth factor (TGF-β) is at least partially responsible for the failure of i.m. and i.v. immunized mice to develop immunity to S. mansoni. Thus, the induction of down-regulatory cytokines may be an important factor limiting the efficacy of certain vaccination protocols. KW - disease models KW - experimental infections KW - failure KW - helminths KW - human diseases KW - immunity KW - immunization KW - inactivated vaccines KW - laboratory animals KW - macrophages KW - parasites KW - schistosomiasis KW - transforming growth factor KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immune sensitization KW - killed vaccines KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007714&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper cytokine expression, IgE production, and tissue eosinophilia. AU - Wynn, T. A. AU - Jankovic, D. AU - Hieny, S. AU - Cheever, A. W. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 154 IS - 9 SP - 4701 EP - 4709 SN - 0022-1767 AD - Wynn, T. A.: Immunology and Cell Biology, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952007401. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 37341-29-0. Subject Subsets: Tropical Diseases; Helminthology N2 - Vaccination of mice with radiation-attenuated cercariae of Schistosoma mansoni results in a highly significant but partial protection against challenge infection. This immunity is dependent on CD4+ T cells, and because of its suppression by anti-interferon-γ (IFN-γ), appears to be caused by a Th1 response. Nevertheless, both Th1 and Th2 lymphokines are expressed in vaccinated and challenged mice, and the authors hypothesized that the expression of the latter group of down-regulatory cytokines may be responsible for the failure to obtain complete protection. Because interleukin-12 (IL-12) is a key cytokine that suppresses Th2-like responses, the authors asked whether IL-12 could increase vaccine-induced immunity to S. mansoni. Indeed, administration of IL-12 significantly reduced worm burdens following a challenge infection. IL-12-treated animals displayed a marked increase in pulmonary IFN-γ and IL-12 p40 mRNA expression, while levels of IL-4, IL-5, and IL-13 were suppressed significantly during the period of vaccination. A marked decrease in serum IgE and tissue eosinophilia, two responses regulated by Th2 cytokines, was also observed. Surprisingly, IL-12 treated/vaccinated mice failed to demonstrate a significant increase in IFN-γ, TNF-α, or nitric oxide synthase mRNA at the time of challenge infection when compared with vaccinated controls, but did, however, display significantly suppressed Th2 cytokine mRNA production. Together, these data demonstrate that exogenous IL-12 regulates Th1/Th2 responses during immunization with irradiated cercariae, and suggest that this cytokine may be used to increase vaccine-induced immunity to S. mansoni. KW - antibodies KW - cytokines KW - disease models KW - eosinophilia KW - experimental infections KW - helminths KW - human diseases KW - IgE KW - immune response KW - immunization KW - immunotherapy KW - interleukin 12 KW - interleukins KW - laboratory animals KW - parasites KW - schistosomiasis KW - T lymphocytes KW - vaccines KW - man KW - mice KW - Schistosoma mansoni KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - reagin KW - reaginic antibodies KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007401&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. AU - Zhou Ping AU - Sieve, M. C. AU - Bennett, J. AU - Kwon-Chung, K. J. AU - Tewari, R. P. AU - Gazzinelli, R. T. AU - Sher, A. AU - Seder, R. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 155 IS - 2 SP - 785 EP - 795 SN - 0022-1767 AD - Zhou Ping: Lymphokine Regulation Unit and Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200534. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9008-11-1. Subject Subsets: Medical & Veterinary Mycology N2 - The regulation of cytokine induction in mice infected with H. capsulatum and the effects of IL-12 in the course of infection were investigated. Mice infected with H. capsulatum and treated with neutralizing antibodies (Ab) to IFN-γ, TNF-γ or IL-2 experienced accelerated mortality, indicating that endogenous production of these cytokines has an important role in response to infection. Mice treated with IL-12 or a neutralizing Ab to IL-4 at the initiation of infection had substantially diminished mortality. Mice infected and treated with IL-12 showed a 2- to 3-fold increase in the amount of IFN-γ following in vitro stimulation with specific H. capsulatum antigens (Ag) compared with control infected mice. The protective effect of IL-12 was abrogated if a neutralizing Ab to IFN-γ was given at the same time, demonstrating that the role of IL-2 in protection was mediated by IFN-γ. Infected mice treated with IL-12 had a several-fold decrease in colony counts of H. capsulatum in spleen cells after 5 d of infection compared with control animals. Spleen cells from infected animals treated with IL-12 showed a striking decrease in their proliferative response to mitogen or H. capsulatum Ag. Responses were restored by addition of inhibitors of IFN-γ or nitric oxide to the in vitro cultures. It is suggested that IL-12 may be useful in immunological intervention against H. capsulatum. KW - cytokines KW - experimental infections KW - histoplasmosis KW - immune response KW - immunology KW - infections KW - interferon KW - interleukins KW - Histoplasma capsulatum KW - mice KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Histoplasma KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Ajellomyces capsulatus KW - fungus KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies. AU - Garraud, O. AU - Nkenfou, C. AU - Bradley, J. E. AU - Perler, F. B. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1995/// VL - 155 IS - 3 SP - 1316 EP - 1325 SN - 0022-1767 AD - Garraud, O.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960802284. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4, 9008-11-1, 207137-56-2. Subject Subsets: Helminthology; Tropical Diseases N2 - Filarial infection is characterized by an immune response associated with the production of antigen (Ag)-specific IgG4 and IgE and interleukin (IL)-4 and IL-5. To identify filarial Ags capable of inducing such responses and to analyse the role Ags play in sustaining it, 24 recombinant filarial parasite proteins were screened for their ability to be recognized by sera from 67 individuals with tissue-invasive filarial (Loa loa or Onchocerca volvulus) infections. Among the recombinant proteins recognized by IgG4 or IgE antibodies in 25% of the sera or more, 2 were selected on the basis of their ability to elicit polyclonal and Ag-specific IgE/IgG4 antibodies in vitro. Ov27 (analogous to Ov7/cystatin, a cysteine proteinase inhibitor) and OvD5B (analogous to Ov33, an aspartyl proteinase inhibitor) induced both a polyclonal and Ag-specific IgE/IgG4 response that was blocked by neutralizing antibodies to IL-4 and IL-3 or by soluble IL-4 receptors. Recombinant human interferon (IFN)-γ and IL-12 also led to a decrease in the production of polyclonal and Ag-specific IgE/IgG4 antibodies. In addition, these 2 recombinant proteins preferentially stimulated the secretion of IL-4, IL-5 and IL-10 (in contrast to IFN-γ). The data suggest that certain epitopes on filarial Ags preferentially elicit a Th2-type response and provide an in vitro model for studying the mechanisms underlying this process. KW - antibodies KW - antigens KW - enzyme inhibitors KW - epitopes KW - filariasis KW - helminths KW - human diseases KW - IgE KW - IgG KW - immune response KW - immunoglobulins KW - in vitro KW - infections KW - interferon KW - interleukin 4 KW - interleukin 5 KW - interleukins KW - onchocerciasis KW - parasites KW - proteins KW - recombinant proteins KW - T lymphocytes KW - Loa loa KW - man KW - Onchocerca volvulus KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Onchocerca KW - African eyeworm KW - antigenic determinants KW - antigenicity KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - reagin KW - reaginic antibodies KW - river blindness KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802284&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mycobacterium tuberculosis infection in pregnant and nonpregnant women infected with HIV in the Women and Infants Transmission Study. AU - Mofenson, L. M. AU - Rodriguez, E. M. AU - Hershow, R. AU - Fox, H. E. AU - Landesman, S. AU - Tuomala, R. AU - Diaz, C. AU - Daniels, E. AU - Brambilla, D. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1995/// VL - 155 IS - 10 SP - 1066 EP - 1072 SN - 0003-9926 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Room 4B11, 6100 Executive Blvd, MSC 7510, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19952008263. Publication Type: Journal Article. Corporate Author: USA, Women and Infants Transmission Study Group Language: English. Number of References: 31 ref. KW - acquired immune deficiency syndrome KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - opportunistic infections KW - pregnancy KW - tuberculosis KW - women KW - USA KW - man KW - Mycobacterium tuberculosis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterium KW - clinical picture KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008263&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Further analysis of the CAP59 locus of Cryptococcus neoformans: structure defined by forced expression and description of a new ribosomal protein-encoding gene. AU - Chang, Y. C. AU - Wickes, B. L. AU - Kwon-Chung, K. J. JO - Gene JF - Gene Y1 - 1995/// VL - 167 IS - 1-2 SP - 179 EP - 183 SN - 0378-1119 AD - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961202270. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology N2 - To dissect the functional region of CAP59, a C. neoformans gene necessary for capsule formation, it was placed under control of the CnGAL7 promoter (pGAL7). Among the several pGAL7::CAP59 fusion constructs, only the one containing the entire open reading frame of CAP59 was able to complement the acapsular phenotype under galactose induction. A missense mutation in the coding region abolished complementation by the fusion construct. The CAP59 locus was contiguous to a convergently transcribed L27 ribosomal protein-encoding gene (CL27). The distance between the cDNA ends of these 2 genes was only 25 bp. CL27 had 2 introns near its N terminus. The translated CL27 protein was 183 amino acids (aa) in length with an estimated molecular mass of 20 kDa, and the first 34 aa at the N terminus could be a targeting peptide for mitochondria. A high degree of restriction fragment length polymorphism was detected in the DNA sequence containing CAP59 and CL27. KW - gene expression KW - genes KW - genetics KW - virulence KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - capsule KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Summary of the 29th United States-Japan joint conference on cholera and related diarrheal diseases. AU - Lang, D. R. AU - Guerrant, R. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 1 SP - 8 EP - 12 SN - 0022-1899 AD - Lang, D. R.: Enteric Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-7630, USA. N1 - Accession Number: 19952004732. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health N2 - The 29th Joint Conference on Cholera and Related Diarrheal Diseases was held in Monterey, California, USA on 1-3 December 1993. This international meeting provided a forum to discuss ongoing research and to promote collaborations between USA and Japanese investigators. More than 130 persons representing 13 countries attended. KW - cholera KW - diarrhoea KW - diseases KW - human diseases KW - Asia KW - Japan KW - North America KW - USA KW - man KW - Vibrio cholerae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - America KW - North America KW - bacterium KW - diarrhea KW - scouring KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004732&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. AU - Secchiero, P. AU - Carrigan, D. R. AU - Asano, Y. AU - Benedetti, L. AU - Crowley, R. W. AU - Komaroff, A. L. AU - Gallo, R. C. AU - Lusso, P. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 2 SP - 273 EP - 280 SN - 0022-1899 AD - Secchiero, P.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bldg. 37, Room 6A11, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952002225. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Public Health N2 - A sensitive and specific polymerase chain reaction method for the detection of human herpesvirus 6 (HHV-6) DNA in serum or plasma has been developed. In total, 157 human serum or plasma samples were studied. HHV-6 DNA was detected in 6 (85.7%) of 7 children with exanthem subitum, 3 (23.1%) of the 13 bone marrow transplant (BMT) recipients, 4 (22.2%) of 18 human immunodeficiency virus (HIV) infected patients, 1 (2.6%) of 39 patients with chronic fatigue syndrome, and none of 37 healthy adults. In the HHV-6 positive BMT recipients, HHV-6 plasma DNA was transiently detected during episodes of fever and respiratory infection. In children with exanthem subitum and in 1 HIV infected patient, the HHV-6 strains were characterized as variant B, whereas variant A was detected in all other patients. Detection of viral DNA in serum or plasma is a marker of active infection that can be used to investigate the role of HHV-6 in human disease. KW - children KW - detection KW - diagnosis KW - human diseases KW - infections KW - polymerase chain reaction KW - North America KW - USA KW - human herpesvirus 6 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - PCR KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002225&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus. AU - Elson, L. H. AU - Calvopiña H., M. AU - Paredes Y., W. AU - Araujo N., E. AU - Bradley, J. E. AU - Guderian, R. H. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 3 SP - 652 EP - 658 SN - 0022-1899 AD - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19950804735. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9008-11-1, 130068-27-8. Subject Subsets: Helminthology; Tropical Diseases N2 - Immunity to Onchocerca volvulus infection is suggested by the presence of putatively immune (PI) subjects in a region of Ecuador in which O. volvulus is endemic. PI subjects were identified by traditional diagnostic methods combined with a polymerase chain reaction-based assay for O. volvulus DNA in skin snips. Responses of peripheral blood mononuclear cells (PBMC) from the PI group (n = 16) were compared with those of people with active infection (microfiladermic subjects; n = 51). PBMC of PI subjects proliferated significantly more to O. volvulus antigen (OvAg) than did PBMC of microfiladermic subjects but less to streptolysin-O. Cytokine analysis of PBMC culture supernatants revealed that PI subjects (n = 11) produced significantly more interferon-γ to OvAg than did those in the microfiladermic group (n =18), less IL-5 to nonparasite antigen and mitogen, and less IL-10 spontaneously. Thus, immunity to O. volvulus may in part be mediated by an antigen-specific Th1-type response. KW - helminths KW - human diseases KW - immunity KW - interferon KW - interleukin 10 KW - interleukin 5 KW - onchocerciasis KW - parasites KW - T lymphocytes KW - Ecuador KW - South America KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804735&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune responsiveness and the pathogenesis of human onchocerciasis. AU - Ottesen, E. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 3 SP - 659 EP - 671 SN - 0022-1899 AD - Ottesen, E. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950804736. Publication Type: Journal Article. Language: English. Number of References: 76 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - This review focuses on the pathogenesis (especially immune-mediated) of Onchocerca-induced tissue damage, after first detailing what is known about the systemic alterations in host responsiveness caused by O. volvulus infection. Prominent antibody but minimal cellular proliferative responses to parasite antigen typify the systemic immune response of patients with onchocerciasis. While components of this response are proinflammatory (and antiparasitic), the primary force driving the immune system is the need to contain or limit inflammation around microfilariae that die in the skin or elsewhere at rates up to hundreds of thousands per day. These dying parasites initiate local inflammatory reactions, with the result being "bystander" tissue damage, which cumulatively determines host pathology. Local and systemic immune mechanisms to contain inflammation (e.g., blocking antibodies, down-regulating cytokines) are prominent in infected patients, and their delineation is crucial to understanding the pathogenesis of onchocercal disease in the skin, eye and elsewhere. The degree of pathology appears to be directly related to both microfilarial numbers and the intensity of proinflammatory responses to them and inversely related to the effectiveness of specific mechanisms to suppress this inflammation. KW - helminths KW - human diseases KW - immunopathology KW - onchocerciasis KW - parasites KW - pathogenesis KW - reviews KW - man KW - Nematoda KW - Onchocerca volvulus KW - Onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - immunopathogenesis KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950804736&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Pneumonia and bacteremia by pneumococcal serotype 16 in a human immunodeficiency virus-infected child with normal serum antibody response to 23-valent Pneumovax vaccine. AU - Hirschfeld, S. AU - Schiffman, G. AU - Tudor-Williams, G. AU - Pizzo, P. A. T2 - Journal of Infectious Diseases JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 3 SP - 761 EP - 762 SN - 0022-1899 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003821. Publication Type: Correspondence. Language: English. Number of References: 10 ref. KW - bacterial diseases KW - children KW - HIV infections KW - human diseases KW - immunization KW - paediatrics KW - pneumonia KW - vaccines KW - man KW - Streptococcus pneumoniae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Streptococcus KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - human immunodeficiency virus infections KW - immune sensitization KW - pediatrics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003821&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes B virus infection. AU - Freifeld, A. G. AU - Hilliard, J. AU - Southers, J. AU - Murray, M. AU - Savarese, B. AU - Schmitt, J. M. AU - Straus, S. E. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 4 SP - 1031 EP - 1034 SN - 0022-1899 AD - Freifeld, A. G.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952004859. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health N2 - Herpes B virus (BV) is a common cause of recurring mucocutaneous infections in monkeys of the genus Macaca. Like its human counterpart, herpes simplex virus (HSV), BV establishes lifelong latency and can be reactivated from infected monkeys symptomatically or asymptomatically. Incidental infection of humans handling BV-shedding monkeys can result in fatal meningoencephalitis. To determine whether humans exposed to infected monkeys can acquire asymptomatic BV infections, 480 subjects were evaluated in a controlled seroprevalence study. Sera from 321 primate handlers, including many with repeated injuries inflicted by Macaca monkeys, and 159 people never exposed to monkeys were tested in blinded fashion by both competition ELISA and Western blot to determine the prevalence of BV and HSV seropositivity. Although 293 persons proved positive for HSV antibodies, no primate handlers or control subjects showed BV-specific antibody responses. There is no serological evidence that BV causes asymptomatic infections in humans. KW - herpes KW - human diseases KW - infection KW - laboratory animals KW - occupational hazards KW - occupations KW - serological surveys KW - seroprevalence KW - workers KW - North America KW - USA KW - cercopithecine herpesvirus 1 KW - man KW - Simplexvirus KW - Alphaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - seroepidemiology KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004859&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy. AU - Kojima, E. AU - Shirasaka, T. AU - Anderson, B. D. AU - Chokekijchai, S. AU - Steinberg, S. M. AU - Broder, S. AU - Yarchoan, R. AU - Mitsuya, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 5 SP - 1152 EP - 1158 SN - 0022-1899 AD - Kojima, E.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19952006100. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 69655-05-6, 30516-87-1. KW - development KW - didanosine KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - mutations KW - patients KW - therapy KW - viraemia KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - therapeutics KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Five-year follow-up of a phase I study of didanosine in patients with advanced human immunodeficiency virus infection. AU - Nguyen, B. Y. AU - Yarchoan, R. AU - Wyvill, K. M. AU - Venzon, D. J. AU - Pluda, J. M. AU - Mitsuya, H. AU - Broder, S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 5 SP - 1180 EP - 1189 SN - 0022-1899 AD - Nguyen, B. Y.: Medicine Branch, Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19952006104. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 69655-05-6. KW - didanosine KW - disease course KW - follow up KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - patients KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dideoxyinosine KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006104&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A phase I/II study of 2′-deoxy-3′-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection. AU - Pluda, J. M. AU - Cooley, T. P. AU - Montaner, J. S. G. AU - Shay, L. E. AU - Reinhalter, N. E. AU - Warthan, S. N. AU - Ruedy, J. AU - Hirst, H. M. AU - Vicary, C. A. AU - Quinn, J. B. AU - Yuen, G. J. AU - Wainberg, M. A. AU - Rubin, M. AU - Yarchoan, R. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 171 IS - 6 SP - 1438 EP - 1447 SN - 0022-1899 AD - Pluda, J. M.: Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19952007870. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 134678-17-4. KW - acquired immune deficiency syndrome KW - antiviral agents KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - lamivudine KW - patients KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 3TC KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007870&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serologic response to human papillomavirus type 16 (HPV-16) virus-like particles in HPV-16 DNA-positive invasive cervical cancer and cervical intraepithelial neoplasia grade III patients and controls from Colombia and Spain. AU - Nonnenmacher, B. AU - Hubbert, N. L. AU - Kirnbauer, R. AU - Shah, K. V. AU - Muñoz, N. AU - Bosch, F. X. AU - Sanjosé, S. de AU - Viscidi, R. AU - Lowy, D. R. AU - Schiller, J. T. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 1 SP - 19 EP - 24 SN - 0022-1899 AD - Nonnenmacher, B.: Laboratory of Cellular Oncology, National Cancer Institute, NIH, Building 36, Room 1D32, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008997. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health; Tropical Diseases N2 - A human papillomavirus (HPV) type 16 virus-like particle-based ELISA was used to assess antivirion immune responses in 300 women participating in cervical cancer case-control studies in Colombia and Spain. Virion IgG antibodies were detected in the sera of 51% and 59% of women with HPV-16 DNA-positive invasive cervical cancer and 81% and 73% of women with HPV-16 DNA-positive cervical intraepithelial neoplasia grade III (CIN III) in Colombia and Spain, respectively. Capsid antibodies were detected in 22% and 3% of cancer controls (P <0.001) and in 43% and 10% of CIN III controls (P = 0.010) from Colombia and Spain, respectively. Since Colombia has an 8-fold higher incidence of cervical cancer, these results demonstrate an association between ELISA positivity and cancer risk. Capsid antibody responses did not correlate with humoral responses of the same women to HPV-16 E6 and E7 oncoproteins. KW - antibodies KW - cervical cancer KW - controls KW - detection KW - ELISA KW - human diseases KW - infections KW - neoplasms KW - patients KW - virus-like particles KW - Colombia KW - Europe KW - South America KW - Spain KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - Papillomaviridae KW - cancers KW - enzyme linked immunosorbent assay KW - human papillomavirus KW - Papovaviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008997&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Seroprevalence of human T cell lymphotropic virus type II infection, with or without human immunodeficiency virus type 1 coinfection, among US intravenous drug users. AU - Briggs, N. C. AU - Battjes, R. J. AU - Cantor, K. P. AU - Blattner, W. A. AU - Yellin, F. M. AU - Wilson, S. AU - Ritz, A. L. AU - Weiss, S. H. AU - Goedert, J. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 1 SP - 51 EP - 58 SN - 0022-1899 AD - Briggs, N. C.: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19952009000. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Public Health N2 - Seroprevalence of human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus type 1 (HIV-1) was determined among 7841 injecting drug users (IDUs) from drug treatment centres in Baltimore, Chicago, Los Angeles, New Jersey (Asbury Park and Trenton), New York City (Brooklyn and Harlem), Philadelphia, and San Antonio, Texas; 20.9% had evidence of HTLV infection, as determined using a p21e EIA for screening and p21e blot for confirmation. With a type-specific EIA and blot used in combination, HTLV-II was identified in 97.6% of HTLV-positive IDUs whose sera could be subtyped. HIV-1 seroprevalence was 13.2%. HTLV-II without HIV-1 was most common in Los Angeles and San Antonio. HIV-1 without HTLV-II was most common in New York, New Jersey, and Baltimore. Dual infection was most common in New York and New Jersey. Logistic regression analysis revealed that seroprevalence of HTLV-II was significantly greater with HIV-1 infection and increasing age and among women, blacks, and Mexican-Americans. In conclusion, it appears that among USA IDUs, nearly all HTLV infection is attributable to HTLV-II, and HTLV-II infection is associated with HIV-1 and sociodemographic background. KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - infections KW - injecting drug users KW - mixed infections KW - seroprevalence KW - North America KW - USA KW - Deltaretrovirus KW - human t-cell lymphotropic virus type ii KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - multiple infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009000&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency. AU - Rausch, D. M. AU - Heyes, M. P. AU - Murray, E. A. AU - Eiden, L. E. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 1 SP - 59 EP - 69 SN - 0022-1899 AD - Rausch, D. M.: Section on Molecular Neuroscience, Laboratory of Cell Biology, National Institute of Mental Health, Bldg. 36, Room 3A17, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008717. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Registry Number: 30516-87-1. KW - animal models KW - central nervous system KW - immunological deficiency KW - infants KW - survival KW - treatment KW - zidovudine KW - Macaca KW - man KW - simian immunodeficiency virus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AZT KW - CNS KW - immune deficiency KW - immunodeficiency KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008717&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transplantation of skin from human immunodeficiency virus type 1-transgenic mice to normal congenic mice results in graft rejection. AU - Dumois, J. A. AU - VanderVegt, F. P. AU - Kopp, J. B. AU - Marinos, N. J. AU - Rooney, J. F. AU - Notkins, A. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 1 SP - 232 EP - 234 SN - 0022-1899 AD - Dumois, J. A.: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bldg. 30, Room 121, 30 CONVENT DR MSC 4322, Bethesda MD 20892-4322, USA. N1 - Accession Number: 19952008724. Publication Type: Journal Article. Language: English. Number of References: 12 ref. KW - animal models KW - envelope protein gp120 KW - graft rejection KW - grafts KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - skin KW - skin grafting KW - transplantation KW - Human immunodeficiency virus 1 KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dermis KW - gp120 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008724&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clearance of circulating filarial antigen as a measure of the macrofilaricidal activity of diethylcarbamazine in Wuchereria bancrofti infection. AU - McCarthy, J. S. AU - Guinea, A. AU - Weil, G. J. AU - Ottesen, E. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 2 SP - 521 EP - 526 SN - 0022-1899 AD - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950809864. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 90-89-1, 1642-54-2. Subject Subsets: Helminthology; Tropical Diseases N2 - Small doses of diethylcarbamazine (DEC) clear microfilariae (MF) from the blood of Wuchereria bancrofti-infected persons, but the dose and regimen required to kill adult worms is not clearly defined. A prospective study was undertaken to examine the macrofilaricidal effect of DEC and the ability of an assay for circulating filarial antigen (CFA) to define the effect. Twenty-five MF-positive subjects and 7 MF-negative but CFA-positive subjects were treated with DEC and followed for 18 months. Of the 25 MF-positive patients, 24 cleared MF, and 22 of 26 CFA-positive subjects cleared CFA. A significantly greater decrease in antifilarial IgG4 was seen in patients who cleared CFA than in those who did not. The complete clearance of CFA observed after therapy with DEC indicates that assessment of CFA clearance is a useful means for detecting macrofilaricidal effects of antifilarial chemotherapy. KW - activity KW - anthelmintics KW - antigens KW - circulating antigens KW - clearance KW - diethylcarbamazine KW - drug therapy KW - filariasis KW - helminths KW - human diseases KW - infection KW - parasites KW - man KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - chemotherapy KW - immunogens KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809864&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased human immunodeficiency virus (HIV) type 1 DNA content and quinolinic acid concentration in brain tissues from patients with HIV encephalopathy. AU - Sei, S. AU - Saito, K. AU - Stewart, S. K. AU - Crowley, J. S. AU - Brouwers, P. AU - Kleiner, D. E. AU - Katz, D. A. AU - Pizzo, P. A. AU - Heyes, M. P. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 3 SP - 638 EP - 647 SN - 0022-1899 AD - Sei, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19952010197. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9007-49-2. KW - brain KW - central nervous system KW - clinical aspects KW - concentration KW - dna KW - encephalopathy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - patients KW - tissues KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - clinical picture KW - CNS KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010197&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The relative distribution of T cell subsets is altered in Jamaican children infected with human T cell lymphotropic virus type 1. AU - Maloney, E. M. AU - Pate, E. AU - Wiktor, S. Z. AU - Morais, P. AU - Mann, D. AU - Gray, R. AU - Manns, A. AU - Blattner, W. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 3 SP - 867 EP - 870 SN - 0022-1899 AD - Maloney, E. M.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd., Room 434, Rockville, MD 20852, USA. N1 - Accession Number: 19952010226. Publication Type: Journal Article. Language: English. Number of References: 13 ref. KW - CD4 antigens KW - children KW - HTLV-I infections KW - human diseases KW - markers KW - risk groups KW - T lymphocytes KW - Jamaica KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - CD4 KW - HLA-DR KW - HTLV-BLV group KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010226&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of macrophage colony-stimulating factor on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus. AU - Roilides, E. AU - Sein, T. AU - Holmes, A. AU - Chanock, S. AU - Blake, C. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 4 SP - 1028 EP - 1034 SN - 0022-1899 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200205. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of recombinant human macrophage colony-stimulating factor (M-CSF) on antifungal activity of human monocytes (MNC), MNC-derived macrophages (MDM) and rabbit pulmonary alveolar macrophages (PAM) against A. fumigatus were studied. MNC-induced hyphal damage was augmented by incubation with M-CSF (P=0.027); PAM-induced hyphal damage was moderately enhanced by M-CSF (P=0.046). Phagocytosis of Aspergillus conidia by MDM and PAM was strongly enhanced by M-CSF (P<0.01). MNC pretreated with M-CSF exhibited enhanced superoxide anion production in response to PMA (P=0.026). This effect was not associated with increased levels of mRNA transcripts of the components of NADPH oxidase, the enzyme responsible for superoxide anion production. It is concluded that M-CSF augments antifungal activity of mononuclear phagocytes against both conidia and hyphae of A. fumigatus partly by enhancement of oxidation-dependent mechanisms and may have an important immunomodulatory role in prevention and treatment of invasive aspergillosis in leukopenic patients. KW - colony stimulating factor KW - immunology KW - monocytes KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200205&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia. AU - Wideroff, L. AU - Schiffman, M. H. AU - Nonnenmacher, B. AU - Hubbert, N. AU - Kirnbauer, R. AU - Greer, C. E. AU - Lowy, D. AU - Lorincz, A. T. AU - Manos, M. M. AU - Glass, A. G. AU - Scott, D. R. AU - Sherman, M. E. AU - Kurman, R. J. AU - Buckland, J. AU - Tarone, R. E. AU - Schiller, J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1995/// VL - 172 IS - 6 SP - 1425 EP - 1430 SN - 0022-1899 AD - Wideroff, L.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962001271. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health N2 - An ELISA to detect serum IgG antibody response to human papillomavirus (HPV) type 16 virus-like particles (VLPs) was evaluated in a case-control study of cervical neoplasia, nested within a prospective cohort study in Oregon, USA. Subjects included 688 controls with continued normal cytology and 152 cases with confirmed incident squamous intraepithelial lesions who were tested for DNA of a broad spectrum of HPV types at cohort enrolment and follow-up. Of controls, 16.6% were seropositive compared with 30.8% and 52.4% of cases with low- and high-grade lesions, respectively. Of HPV-16 DNA-negative subjects, 16.5% were seropositive. Seropositivity increased from 22.2% in subjects who were HPV-16 DNA-positive by polymerase chain reaction once only (enrolment or follow-up) to 83.3% in those who were HPV-16 DNA-positive at both time points. These data imply that serum antibody to HPV-16 VLPs is a relatively sensitive indicator of persisting cervical HPV-16 infection. KW - cervical cancer KW - cervix KW - elisa KW - evaluation KW - human diseases KW - infections KW - neoplasms KW - North America KW - Oregon KW - USA KW - human papillomavirus 16 KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - Papillomaviridae KW - cancer sites KW - cancers KW - enzyme linked immunosorbent assay KW - human papillomavirus KW - Papovaviridae KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. AU - Sacks, D. L. AU - Pimenta, P. F. P. AU - McConville, M. J. AU - Schneider, P. AU - Turco, S. J. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1995/// VL - 181 IS - 2 SP - 685 EP - 697 SN - 0022-1007 AD - Sacks, D. L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950803478. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - The structure and function of the abundant surface lipophosphoglycan (LPG) on Leishmania donovani promastigotes were investigated. During metacyclogenesis, the salient structural feature of LPG was conserved, involving expression of a phosphoglycan chain made up of unsubstituted disaccharide-phosphate repeats. Two important developmental modifications were observed: the size of the molecule was substantially increased because of a 2-fold increase in the number of phosphorylated disaccharide repeat units expressed, and there was a concomitant decrease in the presentation of terminally exposed sugars which was indicated by the reduced accessibility of terminal galactose residues to galactose oxidase and the loss of binding by the lectins, peanut agglutinin and concanavalin A, to metacyclic LPG in vivo and in vitro. The loss of lectin binding was not due to downregulation of the capping oligosaccharides, as the same β-linked galactose or α-linked mannose-terminating oligosaccharides were present in both procyclic and metacyclic promastigotes. The capping sugars on procyclic LPG mediated procyclic attachment to the sand fly (Phlebotomus argentipes) midgut, whereas these same sugars on metacyclic LPG failed to mediate metacyclic binding. Intact metacyclic LPG did not inhibit procyclic attachment but depolymerized LPG did, demonstrating that the ligands are normally buried. The masking of the terminal sugars was attributed to folding and clustering of the extended phosphoglycan chains. The exposure and subsequent masking of the terminal capping sugars explain the stage specificity of promastigote attachment to and release from the vector midgut, which are key events in the development of transmissible infections. KW - developmental stages KW - disease transmission KW - disease vectors KW - host parasite relationships KW - lectins KW - lipophosphoglycans KW - midgut KW - parasites KW - polysaccharides KW - promastigotes KW - transmission KW - vectors KW - Diptera KW - Leishmania donovani KW - Phlebotominae KW - Phlebotomus argentipes KW - protozoa KW - Psychodidae KW - Sarcomastigophora KW - Trypanosomatidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - complex carbohydrates KW - growth phase KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosis. AU - Leno, M. AU - Simpson, R. M. AU - Bowers, F. S. AU - Kindt, T. J. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1995/// VL - 181 IS - 4 SP - 1575 EP - 1580 SN - 0022-1007 AD - Leno, M.: Correspondence address: T. J. Kindt, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Faculty, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland, USA. N1 - Accession Number: 19952007631. Publication Type: Journal Article. Language: English. Number of References: 33 ref. KW - animal models KW - apoptosis KW - HTLV infections KW - human diseases KW - pathogenesis KW - man KW - rabbits KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007631&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activation of virus replication after vaccination of HIV-1-infected individuals. AU - Staprans, S. I. AU - Hamilton, B. L. AU - Follansbee, S. E. AU - Elbeik, T. AU - Barbosa, P. AU - Grant, R. M. AU - Feinberg, M. B. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1995/// VL - 182 IS - 6 SP - 1727 EP - 1737 SN - 0022-1007 AD - Staprans, S. I.: Correspondence address: M.B.Feinberg, Office of AIDS Research, Office of the Director, National Institutes of Health, Building 31, Room 4C06, 31 Center Drive, MSC 2340, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001517. Publication Type: Journal Article. Language: English. Number of References: 54 ref. KW - acquired immune deficiency syndrome KW - CD4+ lymphocytes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunization KW - influenza KW - replication KW - vaccines KW - viraemia KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4+ cells KW - flu KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - T4 lymphocytes KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiple determinants for growth of human immunodeficiency virus type 1 in monocyte-macrophages. AU - Malykh, A. AU - Reitz, M. S. Jr AU - Louie, A. AU - Hall, L. AU - Lori, F. JO - Virology (New York) JF - Virology (New York) Y1 - 1995/// VL - 206 IS - 1 SP - 646 EP - 650 SN - 0042-6822 AD - Malykh, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962003285. Publication Type: Journal Article. Language: English. Number of References: 39 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - monocytes KW - pathogenesis KW - tropisms KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003285&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells. AU - O'Brien, M. C. AU - Ueno, T. AU - Jahan, N. AU - Zajac-Kaye, M. AU - Mitsuya, H. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1995/// VL - 207 IS - 3 SP - 903 EP - 909 SN - 0006-291X AD - O'Brien, M. C.: The Experimental Retrovirology Section, Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002838. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9007-49-2. KW - acquired immune deficiency syndrome KW - antineoplastic agents KW - antiviral agents KW - binding KW - cells KW - DNA KW - HIV infections KW - human diseases KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cytotoxic agents KW - deoxyribonucleic acid KW - expression KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002838&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes. AU - Cara, A. AU - Guarnaccia, F. AU - Reitz, M. S. Jr AU - Gallo, R. C. AU - Lori, F. JO - Virology (New York) JF - Virology (New York) Y1 - 1995/// VL - 208 IS - 1 SP - 242 EP - 248 SN - 0042-6822 AD - Cara, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005073. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. KW - DNA KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - integration KW - macrophages KW - pathogenesis KW - replication KW - t lymphocytes KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005073&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 infection of primary human neuroblasts. AU - Ensoli, F. AU - Cafaro, A. AU - Fiorelli, V. AU - Vannelli, B. AU - Ensoli, B. AU - Thiele, C. J. JO - Virology (New York) JF - Virology (New York) Y1 - 1995/// VL - 210 IS - 1 SP - 221 EP - 225 SN - 0042-6822 AD - Ensoli, F.: Cell and Molecular Biology Section, Paediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005919. Publication Type: Journal Article. Language: English. Number of References: 46 ref. KW - central nervous system KW - hiv infections KW - human diseases KW - nerve tissue KW - neurons KW - Deltaretrovirus KW - Human immunodeficiency virus 1 KW - human t-cell lymphotropic virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - CNS KW - HTLV-BLV group KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - nerve cells KW - neurones KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005919&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread. AU - Toohey, K. AU - Wehrly, K. AU - Nishio, J. AU - Perryman, S. AU - Cheesbro, B. JO - Virology (New York) JF - Virology (New York) Y1 - 1995/// VL - 213 IS - 1 SP - 70 EP - 79 SN - 0042-6822 AD - Toohey, K.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19962008279. Publication Type: Journal Article. Language: English. Number of References: 57 ref. KW - envelope glycoproteins KW - HIV-1 infections KW - human diseases KW - macrophages KW - pathogenesis KW - phenotypes KW - replication KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - hypervariable regions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008279&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits. AU - Leng, M. AU - Hague, B. F. AU - Teller, R. AU - Kindt, T. J. JO - Virology (New York) JF - Virology (New York) Y1 - 1995/// VL - 213 IS - 2 SP - 450 EP - 454 SN - 0042-6822 AD - Leng, M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA. N1 - Accession Number: 19962002639. Publication Type: Journal Article. Language: English. Number of References: 21 ref. KW - apoptosis KW - CD4 antigens KW - genetically engineered organisms KW - HIV infections KW - human diseases KW - immunology KW - T lymphocytes KW - transgenic animals KW - Human immunodeficiency virus 1 KW - man KW - rabbits KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - CD4 KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GMOs KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002639&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of the lower-molecular-mass fraction of venoms from Dendroaspis jamesoni kaimosae and Micrurus fulvius using capillary-electrophoresis electrospray mass spectrometry. AU - Perkins, J. R. AU - Tomer, K. B. JO - European Journal of Biochemistry JF - European Journal of Biochemistry Y1 - 1995/// VL - 233 IS - 3 SP - 815 EP - 827 SN - 0014-2956 AD - Perkins, J. R.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, USA. N1 - Accession Number: 19972005059. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - Capillary electrophoresis (CE) with electrospray ionization (ESI) and selected ion-monitoring mass-spectrometric (SIM-MS) detection was used to provide as much information as possible about the lower molecular-mass fraction (peptides of molecular masses up to 8500 Da) of the venoms of Dendroaspis jamesoni kaimosae (Jameson's mamba) and Micrurus fulvius (Eastern coral snake). Method development was based on the venom of D. jamesoni kaimosae, which contains some previously described peptides, with subsequent application to the completely unknown venom of M. fulvius. CE-ESI-SIM-MS provides a rapid and extremely sensitive method for the detection and molecular-mass determination of peptides present in venoms. It was utilized to provide molecular masses and thus, by inference, confirmation of the peptide compositions for those toxins which have been previously described in the literature. This methodology indicates the presence of 83 peptides in the venom of D. jamesoni kaimosae and 49 peptides in the venom of M. fulvius in the molecular-mass range 6000-8500 Da. KW - characterization KW - electrophoresis KW - mass spectrometry KW - peptides KW - venoms KW - Dendroaspis KW - Micrurus fulvius KW - snakes KW - Elapidae KW - snakes KW - reptiles KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Micrurus KW - Dendroaspis jamesoni kaimosae KW - venom KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005059&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reexamining AIDS research priorities. AU - Paul, W. E. JO - Science (Washington) JF - Science (Washington) Y1 - 1995/// VL - 267 IS - 5198 SP - 633 EP - 636 SN - 0036-8075 AD - Paul, W. E.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952003702. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health N2 - The director of the NIH's Office of AIDS Research summarizes the scientific opportunities afforded by AIDS research, ranging from protective immunity and cytokines to behavioural research and prevention of sexually transmitted diseases and female barrier methods.D.W. FitzSimons KW - acquired immune deficiency syndrome KW - animal models KW - behaviour KW - HIV infections KW - immunology KW - policy KW - research KW - sexually transmitted diseases KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - behavior KW - human immunodeficiency virus infections KW - sexually transmitted infections KW - STDs KW - studies KW - United States of America KW - venereal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003702&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Influence of valine flooding on channeling of valine into tissue pools and on protein synthesis. AU - Smith, C. B. AU - Sun, Y. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1995/// VL - 268 IS - 4 SP - E735 EP - E744 SN - 0002-9513 AD - Smith, C. B.: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951408057. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 72-18-4. Subject Subsets: Human Nutrition N2 - Rates of valine incorporation into protein were measured under control and valine-"flooding" conditions in Sprague-Dawley rats and included correction for the degree of recycling of unlabelled valine derived from the steady-state breakdown of tissue protein into the precursor pool (tRNA bound). The correction factor λ, which is the ratio of the steady-state specific activity of valine in the tissue tRNA-bound pool to that in the arterial plasma, was estimated for each of the tissues. In controls, values of λ ranged from 0.31 in adrenals to 0.54 in heart; in flooded rats, values were higher, but only in liver was the value of λ close to 1.0. In control and flooded rats, rates of protein synthesis were highest in liver and adrenals and lowest in skeletal muscle, with intermediate values in brain and heart. Flooding resulted in increased rates of protein synthesis in liver and decreased rates in adrenals. Rates of protein synthesis in brain, heart and skeletal muscle were not significantly affected by flooding. KW - amino acids KW - infusion KW - protein synthesis KW - tissues KW - valine KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - protein biosynthesis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408057&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats. AU - Corwin, R. L. AU - Rowe, P. M. AU - Crawley, J. N. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1995/// VL - 269 IS - 3, 2 SP - R511 EP - R518 SN - 0002-9513 AD - Corwin, R. L.: Section on Behavioural Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951414333. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - The neuropeptide galanin has been proposed to play a role in the regulation of fat intake. The purpose of the present investigation was to examine if galanin and the galanin receptor antagonist M40 would have selective effects on fat intake in a fat-diet choice paradigm in male Sprague-Dawley rats. Rats were adapted to 22-h access to diet alone and 2-h daily access to separate sources of fat and diet in the early dark cycle. Galanin (300 pmol, 1 nmol) or M40 (2-500 pmol) was micro inserted bilaterally into the paraventricular nucleus of the hypothalamus (PVN) before the 2-h choice period, and diet and fat intake were measured. M40 had no effect on diet or fat intake. Galanin stimulated diet intake and increased the ratio of diet to fat consumed but had no significant effect on fat intake alone. These results suggest that endogenous galanin in the PVN may not play a primary role in the regulation of fat intake when fat is available in addition to a nutritionally balanced diet. KW - antagonists KW - fats KW - food intake KW - intake KW - neuropeptides KW - obesity KW - receptors KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414333&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of HIV-1 gag protein subcellular targeting by protein kinase C. AU - Yu, G. AU - Shen, F. S. AU - Sturch, S. AU - Aquino, A. AU - Glazer, R. I. AU - Felsted, R. L. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 9 SP - 4792 EP - 4796 SN - 0021-9258 AD - Yu, G.: Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19952005414. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 9026-43-1. KW - biochemistry KW - cellular biology KW - gag protein KW - gene expression KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - phosphorylation KW - protein kinase KW - regulation KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cell biology KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. AU - Welch, R. W. AU - Wang, Y. AU - Crossman, A., Jr. AU - Park, J. B. AU - Kirk, K. L. AU - Levine, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 21 SP - 12584 EP - 12592 SN - 0021-9258 AD - Welch, R. W.: Laboratory of Cell Biology and Genetics, National Institutes of Health, Bethesda, Maryland 20892-0850, USA. N1 - Accession Number: 19961403421. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 50-81-7, 490-83-5. Subject Subsets: Human Nutrition N2 - To investigate whether ascorbate alone, dehydroascorbic acid alone, or both are transported into cells, specific assays for each compound, freshly synthesized pure dehydroascorbic acid, the specially synthesized analogue 6-chloroascorbate, and a new assay for 6-chloroascorbate were undertaken. Ascorbate and dehydroascorbic acid were transported and accumulated distinctly; neither competed with the other. Ascorbate was accumulated as ascorbate by sodium-dependent carrier-mediated active transport. Dehydroascorbic acid transport and accumulation as ascorbate was at least 10-fold faster than ascorbate transport and was sodium-independent. Once transported, dehydroascorbic acid was immediately reduced intracellularly to ascorbate. The analogue 6-chloroascorbate had no effect on dehydroascorbic acid transport but was a competitive inhibitor of ascorbate transport. The Ka for 6-chloroascorbate (2.9-4.4 µM) was similar to the Km for ascorbate transport (9.8-12.6 µM). 6-Chloroascorbate was itself transported and accumulated in fibroblasts by a sodium-dependent transporter. The data provide new information that ascorbate and dehydroascorbic acid are transported into neutrophils and fibroblasts by 2 distinct mechanisms and that the compound available for intracellular utilization is ascorbate. KW - active transport KW - analogues KW - ascorbic acid KW - cell cultures KW - dehydroascorbic acid KW - transport KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - accumulation KW - analogs KW - transportation KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403421&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification of a variant-specific surface protein of Giardia lamblia and characterization of its metal-binding properties. AU - Luján, H. D. AU - Mowatt, M. R. AU - Wu JingJing AU - Lu Yun AU - Lees, A. AU - Chance, M. R. AU - Nash, T. E. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 23 SP - 13807 EP - 13813 SN - 0021-9258 AD - Luján, H. D.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960800373. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 52-90-4, 7439-89-6, 7440-66-6. Subject Subsets: Protozoology N2 - Giardia lamblia [G. duodenalis] undergoes surface antigenic variation by modulating the expression of different variant-specific surface proteins (VSP) which are cysteine-rich and bind zinc and other heavy metals in vitro. An immunoaffinity chromatographic method was developed to purify a VSP in order to determine its biochemical properties. The sequences of 2 different proteolytic fragments agreed with the sequence deduced from the cloned gene and the amino-terminal sequence indicated the removal of a 14-residue signal peptide, consistent with the transport of VSP to the cell surface. The protein was not glycosylated and had an isoelectric point of 5.3. X-ray microanalyses indicated that the major metals in G. lamblia trophozoites, as well as in purified VSP, are zinc and iron. The zinc concentration in G. lamblia cells was found to be 0.43 and the iron concentration 0.80 mM. It is proposed that metal coordination stabilizes the VSPs, rendering them resistant to proteolytic attack in the upper small intestine. The ability of G. lamblia to bind ions may play a role in nutritional deficiency and/or malabsorption in heavily infected persons. KW - binding KW - binding proteins KW - biochemistry KW - chromatography KW - cysteine KW - cytochemistry KW - giardiasis KW - human diseases KW - ions KW - iron KW - malabsorption KW - metals KW - nutrient deficiencies KW - parasites KW - proteins KW - proteolysis KW - purification KW - small intestine KW - surface proteins KW - zinc KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - carrier proteins KW - giardiosis KW - malabsorption syndrome KW - membrane proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800373&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. AU - Bebenek, K. AU - Beard, W. A. AU - Casas-Finet, J. R. AU - Kim, H. R. AU - Darden, T. A. AU - Wilson, S. H. AU - Kunkel, T. A. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 33 SP - 19516 EP - 19523 SN - 0021-9258 AD - Bebenek, K.: Correspondence address: T. A. Kunkel, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19962001070. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9068-38-6. KW - amino acids KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - reverse transcriptase KW - structure KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001070&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates. AU - Ueno, T. AU - Shirasaka, T. AU - Mitsuya, H. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 40 SP - 23605 EP - 23611 SN - 0021-9258 AD - Ueno, T.: Correspondence address: H. Mitsuya, The Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Building 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19962001615. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9068-38-6. KW - analogues KW - drug resistance KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - nucleoside analogues KW - nucleosides KW - reverse transcriptase KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - analogs KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001615&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection. AU - Freed, E. O. AU - Martin, M. A. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 41 SP - 23883 EP - 23886 SN - 0021-9258 AD - Freed, E. O.: Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19962002680. Publication Type: Journal Article. Language: English. Number of References: 153 ref. KW - acquired immune deficiency syndrome KW - envelope glycoproteins KW - HIV infections KW - human diseases KW - life cycle KW - molecular biology KW - proteins KW - reviews KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - function KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002680&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A helical epitope in the C4 domain of HIV glycoprotein 120. AU - Robey, F. A. AU - Kelson-Harris, T. AU - Roller, P. P. AU - Robert-Guroff, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1995/// VL - 270 IS - 41 SP - 23918 EP - 23921 SN - 0021-9258 AD - Robey, F. A.: Peptide and Immunochemistry Unit, Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002682. Publication Type: Journal Article. Language: English. Number of References: 19 ref. KW - acquired immune deficiency syndrome KW - antibodies KW - envelope protein gp120 KW - envelope proteins KW - epitopes KW - HIV infections KW - human diseases KW - molecular biology KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - antigenic determinants KW - domain KW - gp120 KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Scope of the AIDS epidemic in the United States. AU - Rosenberg, P. S. JO - Science (Washington) JF - Science (Washington) Y1 - 1995/// VL - 270 IS - 5240 SP - 1372 SN - 0036-8075 AD - Rosenberg, P. S.: National Cancer Institute, Rockville, MD 20852-4910, USA. N1 - Accession Number: 19962001059. Publication Type: Journal Article. Language: English. Number of References: 20 ref. KW - acquired immune deficiency syndrome KW - epidemiology KW - ethnic groups KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mathematical models KW - surveillance KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001059&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Birth weight and perinatal mortality: a comparison of the United States and Norway. AU - Wilcox, A. AU - Skjærven, R. AU - Buekens, P. AU - Kiely, J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 273 IS - 9 SP - 709 EP - 711 SN - 0098-7484 AD - Wilcox, A.: Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19962001427. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health N2 - The authors set out to compare perinatal mortality in the USA and Norway, using a new analytic approach based on relative birth weight. They compared linked birth and perinatal death records for USA and Norwegian births from 1986 through 1987, the most recently available 2-year period. A total of 7 445 914 USA births and 105 084 Norwegian births. The higher rate of perinatal death in the USA compared with Norway is due to an excess of preterm deliveries in the USA. Low-weight, preterm births comprise 2.9% of US births compared with 2.1% of Norwegian births. If the USA could eliminate this slight excess of preterm delivery, perinatal mortality in the USA would decrease to the level in Norway. Unexpectedly, the survival of newborns at any given birth weight is virtually the same in the USA and Norway when newborns' birth weights are considered relative to their own nation's weight. Low rates of perinatal mortality in the Scandinavian countries have usually been attributed to the heavier weights of their newborns. Higher mortality among USA infants is in fact due entirely to a small excess of preterm deliveries. The lighter weights of USA newborns at term appear not to affect perinatal survival. Furthermore, the apparent survival advantage of low-weight USA newborns (used by policymakers as evidence of superior USA intensive neonatal care) may be at least partly an artifact. When weight-specific mortality rates are adjusted to relative low birth weight, low-weight newborns have the same survival in Norway as in the USA. The prevention of excess mortality among USA infants is concluded to depend on the prevention of preterm births, not on changes in mean birth weight. KW - birth weight KW - comparisons KW - infants KW - low birth weight infants KW - mortality KW - neonates KW - perinatal mortality KW - Europe KW - North America KW - Norway KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - Developed Countries KW - EFTA KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - APEC countries KW - North America KW - death rate KW - newborn infants KW - United States of America KW - Demography (UU200) KW - Human Fertility (UU250) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001427&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell lymphotropic virus type I-associated adult T-cell leukemia. The Joseph Goldberger Clinical Investigator Lecture. AU - Waldmann, T. A. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 273 IS - 9 SP - 735 EP - 737 SN - 0098-7484 AD - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, Bldg 10, Room 4N115, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952008212. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 85898-30-2, 102524-44-7. KW - adult T-cell leukaemia KW - human diseases KW - immunotherapy KW - interleukin 2 KW - monoclonal antibodies KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - retroviridae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adult T-cell leukemia KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Promising new treatments for cytomegalovirus retinitis. AU - Polis, M. A. AU - Masur, H. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 273 IS - 18 SP - 1457 EP - 1459 SN - 0098-7484 AD - Polis, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19952006928. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health N2 - A commentary. KW - human diseases KW - infections KW - retinitis KW - reviews KW - Human herpesvirus 5 KW - man KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human cytomegalovirus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006928&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breast cancer among radiologic technologists. AU - Boice, J. D., Jr. AU - Mandel, J. S. AU - Doody, M. M. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 274 IS - 5 SP - 394 EP - 401 SN - 0098-7484 AD - Boice, J. D., Jr.: Radiation Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, EPN/Room 408, Bethesda, MD 20892, USA. N1 - Accession Number: 19962000336. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health N2 - Of 105 385 female radiological technologists (certified by the American Registry of Radiologic Technologists since 1926) sent questionnaires to evaluate the risk of occupation associated breast cancer, 79 016 responded. Six hundred breast cancer cases were identified. Each of 528 eligible subjects with breast cancer was matched to five control subjects based on age, year of certification, and follow-up time. Study subjects had been certified for a mean of 29 years; 63.8% of cases and 62.6% of controls had worked as radiological technologists for 10 years or more. Significantly increased risks for breast cancer were associated with early age at menarche (for <11 years of age: RR = 1.79: 95% confidence interval [CI], 1.09 to 2.94), nulliparity (PR = 1.36; 95% CI, 1.04 to 1.78), first-degree relative with history of breast cancer (RR = 2.07; 95% CI, 1.56 to 2.74), prior breast biopsy (RR = 1.53; 95% CI, 1.17 to 2.00), alcohol consumption (for >14 alcoholic drinks per week: RR = 2.12; 95% CI, 1.06 to 4.27), thyroid cancer (RR = 5.36; 95% CI, 1.64 to 17.5), hyperthyroidism (RR = 1.66; 95% CI, 1.02 to 2.71), and residence in the northeastern USA (RR = 1.66; 95% CI, 1.19 to 2.30). Jobs involving radiotherapy, radioisotopes, or fluoroscopic equipment, however, were not linked to breast cancer risk, nor were personal exposures to fluoroscopy or multifilm procedures. Use of birth control pills, postmenopausal oestrogens, or permanent hair dyes also were not risk factors. Based on dosimetry records for 35% of study subjects, cumulative exposure appeared low. Among women who worked more than 20 years, the RR for breast cancer was 1.13 (95% CI, 0.79 to 1.64). The authors conclude that more than 50% of the reported breast cancers could be explained by established risk factors. Employment as a radiological technologist, however, was not found to increase the risk of breast cancer. The contribution of prolonged exposure to relatively low doses of ionizing radiation to breast cancer risk was too small to be detectable at this time. KW - breast KW - breast cancer KW - health care workers KW - human diseases KW - ionizing radiation KW - neoplasms KW - occupational health KW - occupations KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000336&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Studies of cancer and radiation dose among atomic bomb survivors. AU - Land, C. E. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 274 IS - 5 SP - 402 EP - 407 SN - 0098-7484 AD - Land, C. E.: Radiation Epidemiology Branch, National Cancer Institute, EPN 408, 6130 Executive Blvd, MS 7362, Bethesda, MD 20892-7362, USA. N1 - Accession Number: 19952009727. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health N2 - A comprehensive programme of medical follow-up of survivors of the atomic bombings of Hiroshima and Nagasaki, Japan, by the Radiation Effects Research Foundation (RERF) has produced quantitative estimates of cancer risk from exposure to ionizing radiation. For breast cancer in women, in particular, the strength of the radiation dose response and the generally low level of population risk in the absence of radiation exposure have led to a clear description of excess risk and its variation by age at exposure and over time following exposure. Comparisons of RERF data with data from medically irradiated populations have yielded additional information on the influence of population and underlying breast cancer rates on radiation-related risk. Epidemiological investigations of breast cancer cases and matched controls among atomic bomb survivors have clarified the role of reproductive history as a modifier of the carcinogenic effects of radiation exposure. Finally, a pattern of radiation-related risk by attained age among the survivors exposed during childhood or adolescence suggests the possible existence of a radiation-susceptible sub-group. The hypothetical existence of such a group is lent plausibility by the results of recent family studies suggesting that heritable mutations in certain genes are associated with familial aggregations of breast cancer. The recent isolation and cloning of one such gene, BRCA1, makes it likely that the hypothesis can be tested using molecular assays of archival and other tissue obtained from atomic bomb survivor cases and controls. KW - breast KW - breast cancer KW - epidemiology KW - fallout KW - human diseases KW - ionizing radiation KW - neoplasms KW - risk factors KW - Asia KW - Japan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - radioactive fallout KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009727&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HDL cholesterol predicts coronary heart disease mortality in older persons. AU - Corti, M. C. AU - Guralnik, J. M. AU - Salive, M. E. AU - Harris, T. AU - Field, T. S. AU - Wallace, R. B. AU - Berkman, L. F. AU - Seeman, T. E. AU - Glynn, R. J. AU - Hennekens, C. H. AU - Havlik, R. J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 274 IS - 7 SP - 539 EP - 544 SN - 0098-7484 AD - Corti, M. C.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD, USA. N1 - Accession Number: 19961404283. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The relation of total cholesterol and HDL cholesterol (HDL-C) with coronary heart disease (CHD) mortality and with occurrence of new CHD events in persons >71 years old was examined in 2527 women and 1377 men. New CHD events were evaluated in persons with no CHD history or hospitalization. Death due to CHD. After adjustment for established CHD risk factors, the relative risk (RR) of death due to CHD for those with low HDL-C (<0.90 mmol/litre) compared with the reference group (HDL-C ≥1.55 mmol/litre) was 2.5 (95% confidence interval (CI) 1.6-4.0). Elevated risk was present in subgroups 71-80 years old (RR 4.1; 95% CI 1.9-8.8) and over 80 years (RR 1.8; 95% CI 0.99-3.4), and in men and women. Low HDL-C predicted an increased risk of occurrence of new CHD events (RR 1.4; 95% CI 1.1-2.0), with similar but nonsignificant results in subgroups of men and women. Total cholesterol was less consistently associated with CHD mortality than HDL-C. When individuals with total cholesterol of at least 6.20 mmol/litre were compared with the reference group with total cholesterol of 4.16-5.19 mmol/litre, a significant risk of CHD mortality was seen for women (RR 1.8; 95% CI 1.03-3.0) but not for men (RR 1.0; 95% CI 0.5-2.0). In the total population, for each 1-unit increase in the total cholesterol/HDL-C ratio there was a 17% increase in the risk of CHD death that was significant. Low HDL-C predicts CHD mortality and occurrence of new CHD events in persons older than 70 years. Elevated total cholesterol was not found to be associated with CHD mortality in older men, but may be a risk factor for CHD in older women. KW - atherosclerosis KW - blood lipids KW - cholesterol KW - heart diseases KW - high density lipoprotein KW - mortality KW - old age KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - arteriosclerosis KW - coronary diseases KW - death rate KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404283&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety of the blood supply. AU - Sloand, E. M. AU - Pitt, E. AU - Klein, H. G. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1995/// VL - 274 IS - 17 SP - 1368 EP - 1373 SN - 0098-7484 AD - Sloand, E. M.: National Heart, Lung and Blood Institute, 31 Center Drive, MSC 2490, Building 31, Room 4A11, Bethesda, MD 20892-2490, USA. N1 - Accession Number: 19962000622. Publication Type: Journal Article. Language: English. Number of References: 108 ref. KW - blood transfusion KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - safety KW - transmission KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962000622&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ascorbic acid transport and distribution of human B lymphocytes. AU - Bergsten, P. AU - Yu, R. AU - Kehrl, J. AU - Levine, M. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1995/// VL - 317 IS - 1 SP - 208 EP - 214 SN - 0003-9861 AD - Bergsten, P.: Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland 20892, USA. N1 - Accession Number: 19951413547. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Ascorbic acid transport was investigated in human B lymphocytes. The vitamin was transported by 2 components. The first was a high-affinity activity with an apparent Km of 7-10 µM and Vmax of 0.14 mM/h (3.11 × 10-4µmol × h-1× mg protein-1). The activity was concentration and temperature dependent, saturable and inhibited by carbonylcyanide-p-trifluoromethoxyphenylhydrazone and ouabain and generated ascorbic acid accumulation against a concentration gradient. Kinetics for the second component were indeterminate because ascorbate was not accumulated against a concentration gradient. Subcellular fractionation revealed that intracellular ascorbic acid in human B lymphocytes was >90% localized to the cytosol and not protein bound. Kinetic parameters of high-affinity ascorbic acid transport could operate effectively with plasma concentrations normally found in man. KW - ascorbic acid KW - distribution KW - lymphocytes KW - transport KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - transportation KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Prophylactic immune globulin in children with HIV disease. AU - Mofenson, L. M. AU - Nugent, R. AU - Spector, S. A.\Gelber, R. D.\Wara, D. W. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1995/// VL - 332 IS - 11 SP - 750 EP - 751 SN - 0028-4793 AD - Mofenson, L. M.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004309. Publication Type: Correspondence. Language: English. Number of References: 8 ref. Registry Number: 308067-57-4, 723-46-6, 738-70-5. KW - clinical trials KW - HIV infections KW - human diseases KW - immunoglobulins KW - immunotherapy KW - prophylaxis KW - sulfamethoxazole KW - treatment KW - trimethoprim KW - gamma-globulins KW - human immunodeficiency virus infections KW - immune globulins KW - sulphamethoxazole KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004309&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A population-based serologic survey of immunity to tetanus in the United States. AU - Gergen, P. J. AU - McQuillan, G. M. AU - Kiely, M. AU - Ezzati-Rice, T. M. AU - Sutter, R. W. AU - Virella, G. AU - Sanford, J. P. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1995/// VL - 332 IS - 12 SP - 761 EP - 766 SN - 0028-4793 AD - Gergen, P. J.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19962001357. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health N2 - To provide more accurate estimates, serum levels of antibody against tetanus were measured as part of the third National Health and Nutrition Examination Survey (NHANES III), which studied a representative sample of the civilian, non-institutionalized population of the USA. The authors measured tetanus antitoxin using a solid-phase enzyme immunoassay in serum samples from 10 618 persons 6 years of age and older who were examined during phase 1 of NHANES III in 1988 to 1991. Overall, 69.7% of Americans 6 years of age and older had protective levels of tetanus antibodies (>0.15 IU/ml). The rate decreased from 87.7% among those 6 to 11 years of age to 27.8% among those 70 years of age or older. Among children 6 to 16 years of age, 82.2% had protective levels of tetanus antibodies, with little variation according to race or ethnicity. More men than women were immune (79.0% vs. 62.4%). Mexican Americans had a significantly lower rate of immunity (57.9%, P <0.05) than either non-Hispanic whites (72.7%) or non-Hispanic blacks (68.1%). Those with a history of military service, higher levels of education, or incomes above the poverty level were more likely to have protective antibody levels. Although the prevalence of immunity declined rapidly starting at the age of 40 years, most of the 107 cases of tetanus (with 20 deaths) reported in 1989 and 1990 occurred in persons 60 years of age or older. Despite the fact that effective vaccines against tetanus have been available since the 1940s, many Americans do not have immunity to tetanus, and the rates are lowest among the elderly. There is an excellent correlation between vaccination rates (96%) and immunity (96%) among 6-year-olds. However, antibody levels decline over time, and one fifth of older children (10 to 16 years of age) do not have protective antibody levels. [An editorial by J.P. Sanford entitled "tetanus-forgotten but not gone" discusses tetanus immunization further.] KW - editorials KW - human diseases KW - immunity KW - immunization KW - immunization programmes KW - serological surveys KW - tetanus KW - vaccines KW - North America KW - USA KW - Clostridium tetani KW - man KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - bacterium KW - immune sensitization KW - immunization programs KW - lockjaw KW - seroepidemiology KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Human immunodeficiency virus. AU - Arthur, L. O. AU - Henderson, L. E. AU - Benveniste, R. E. AU - Phillips, D. M. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1995/// VL - 332 IS - 25 SP - 1719 EP - 1719 SN - 0028-4793 AD - Arthur, L. O.: National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19952009884. Publication Type: Correspondence. Language: English. Number of References: 4 ref. KW - electron microscopy KW - envelope glycoproteins KW - human diseases KW - human immunodeficiency viruses KW - membranes KW - proteins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009884&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Homocysteine metabolism in pregnancies complicated by neural-tube defects. AU - Mills, J. L. AU - McPartlin, J. M. AU - Kirke, P. N. AU - Lee, Y. J. AU - Conley, M. R. AU - Weir, D. G. AU - Scott, J. M. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1995/// VL - 345 IS - 8943 SP - 149 EP - 151 SN - 0140-6736 AD - Mills, J. L.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19951412228. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 68-19-9, 59-30-3, 6027-13-0. Subject Subsets: Human Nutrition N2 - Folic acid taken around the time of conception can prevent many neural-tube defects. Women with low-normal vitamin B12 values may also be at increased risk. Whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects was studied. Blood was obtained during pregnancies that produced 81 infants with neural-tube defects and 323 normal children. Samples were assayed for homocysteine, methylmalonic acid, plasma folate, red-cell folate, and B12. Mothers of children with neural-tube defects had significantly higher homocysteine values (8.62 μmol/litre) than did B12 matched controls (7.96 μmol/litre, P=0.03). The difference was significant (P=0.004) in the lower half of the B12 distribution after adjusting for plasma folate. Results show that an abnormality in homocysteine metabolism, apparently related to methionine synthase, is present in many women who give birth to children with neural-tube defects. Overcoming this abnormality is likely to be the mechanism by which folic acid prevents neural-tube defects. These findings suggest that the most effective periconceptional prophylaxis to prevent neural-tube defects may require B12 as well as folic acid. KW - cyanocobalamin KW - fetal development disorders KW - folic acid KW - homocysteine KW - infants KW - metabolism KW - pregnancy KW - prevention KW - supplements KW - vitamin b12 KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cobalamin KW - foetal development disorders KW - folacin KW - folate KW - gestation KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene therapy and immune restoration for HIV disease. AU - Bridges, S. H. AU - Sarver, N. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1995/// VL - 345 IS - 8947 SP - 427 EP - 432 SN - 0140-6736 AD - Bridges, S. H.: Correspondence address: N. Sarver, Targeted Interventions Bramch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building, Bethesda, MD 20898-7620, USA. N1 - Accession Number: 19952002745. Publication Type: Journal Article. Language: English. Number of References: 47 ref. KW - acquired immune deficiency syndrome KW - gene therapy KW - HIV infections KW - human diseases KW - immunity KW - immunopathology KW - treatment KW - vaccine development KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus infections KW - immunopathogenesis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Search for HIV-1 group O infection in Nigeria. AU - Dada, A. J. AU - Olumide, Y. M. AU - Henrard, D. R. AU - Phelps, B. AU - Pau, C. P. AU - Quinn, T. C. AU - Biggar, R. J. AU - O'Brien, T. R. AU - Blattner, W. A. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1995/// VL - 345 IS - 8962 SP - 1436 EP - 1436 SN - 0140-6736 AD - Dada, A. J.: Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. N1 - Accession Number: 19952005814. Publication Type: Correspondence. Language: English. Number of References: 5 ref. KW - acquired immune deficiency syndrome KW - aetiology KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Nigeria KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - AIDS KW - causal agents KW - etiology KW - group O infection KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005814&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment of HIV-associated Kaposi's sarcoma with paclitaxel. AU - Saville, M. W. AU - Lietzau, J. AU - Pluda, J. M. AU - Feuerstein, I. AU - Odom, J. AU - Wilson, W. H. AU - Humphrey, R. W. AU - Feigal, E. AU - Steinberg, S. M. AU - Broder, S. AU - Yarchoan, R. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1995/// VL - 346 IS - 8966 SP - 26 EP - 28 SN - 0140-6736 AD - Saville, M. W.: Correspondence address: Dr Robert Yarchoan, Building 10, Room 12N226, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19952005990. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 33069-62-4. KW - acquired immune deficiency syndrome KW - adverse effects KW - antineoplastic agents KW - dosage KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - opportunistic infections KW - paclitaxel KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AIDS KW - cytotoxic agents KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - taxol KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005990&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Conjunctival malignant disease with AIDS in USA. AU - Goedert, J. J. AU - Coté, T. R. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1995/// VL - 346 IS - 8969 SP - 257 EP - 258 SN - 0140-6736 AD - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19952007203. Publication Type: Correspondence. Language: English. Number of References: 5 ref. KW - acquired immune deficiency syndrome KW - conjunctiva KW - eye diseases KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - melanoma KW - neoplasms KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cancers KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007203&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. AU - Lunardi-Iskandar, Y. AU - Bryant, J. L. AU - Zeman, R. A. AU - Lam, V. H. AU - Samaniego, F. AU - Besnier, J. M. AU - Hermans, P. AU - Thierry, A. R. AU - Gill, P. AU - Gallo, R. C. JO - Nature (London) JF - Nature (London) Y1 - 1995/// VL - 375 IS - 6526 SP - 64 EP - 68 SN - 0028-0836 AD - Lunardi-Iskandar, Y.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19952004552. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 53321-48-5, 11130-48-6, 9002-61-3. KW - acquired immune deficiency syndrome KW - animal models KW - chorionic gonadotropin KW - HIV infections KW - hormones KW - human diseases KW - kaposi's sarcoma KW - metastasis KW - neoplasms KW - pathogenesis KW - pregnancy KW - women KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - AIDS KW - cancers KW - choriogonadotropin KW - gestation KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004552&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. AU - Wynn, T. A. AU - Cheever, A. W. AU - Jankovic, D. AU - Poindexter, R. W. AU - Caspar, P. AU - Lewis, F. A. AU - Sher, A. JO - Nature (London) JF - Nature (London) Y1 - 1995/// VL - 376 IS - 6541 SP - 594 EP - 596 SN - 0028-0836 AD - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19950807573. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Helminthology N2 - It has previously been shown in mice that interleukin (IL)-12 administered peritoneally with schistosome eggs prevents subsequent pulmonary granuloma formation on intravenous challenge with eggs. It is now shown that sensitization with eggs plus IL-12 partly inhibits granuloma formation and dramatically reduces the tissue fibrosis induced by natural infection with Schistosoma mansoni worms. These results are an example of a vaccine against parasites which acts by preventing pathology rather than infection. IL-12 is known to favour the priming of Th1 rather than Th2 cells, and the effects on fibrosis are accompanied by replacement of the Th2-dominated pattern of cytokine expression characteristic of S. mansoni infection with one dominated by Th1 cytokines. Elevated Th2 cytokine expression and fibrosis are common manifestations of wide variety of infectious diseases and atopic disorders which might be ameliorated by vaccination with antigen and IL-12. KW - cytokines KW - experimental infections KW - fibrosis KW - helminths KW - human diseases KW - immunotherapy KW - interleukin 12 KW - laboratory animals KW - parasites KW - schistosomiasis KW - vaccination KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807573&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Kaposi's sarcoma in pregnant women. AU - Rabkin, C. S. AU - Chibwe, G. AU - Muyunda, K. AU - Musaba, E. AU - Berger, P. AU - Dirnhofer, S. AU - Lunardi-Iskandar, Y.\Zeman, R. A.\Lam, V. H.\Samaniego, F.\Thierry, A. R.\Gallo, R. C.\Bryant, J. L. T2 - Nature (London) JO - Nature (London) JF - Nature (London) Y1 - 1995/// VL - 377 IS - 6544 SP - 21 EP - 22 SN - 0028-0836 AD - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, EPN/434, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009182. Publication Type: Correspondence. Language: English. Number of References: 20 ref. KW - hcg KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - kaposi's sarcoma KW - pregnancy KW - women KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gestation KW - human chorionic gonadotropin KW - human gonadotropic hormone KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - urogonadotropin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009182&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of apoptosis in mature T cells by tumour necrosis factor. AU - Zheng, L. AU - Fisher, G. AU - Miller, R. E. AU - Peschon, J. AU - Lynch, D. H. AU - Lenardo, M. J. JO - Nature (London) JF - Nature (London) Y1 - 1995/// VL - 377 IS - 6545 SP - 348 EP - 351 SN - 0028-0836 AD - Zheng, L.: Correspondence address: M. J. Lenardo, Laboratory of Immunology, National Institite of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19952009608. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 308079-78-9. KW - apoptosis KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - T lymphocytes KW - tumour necrosis factor KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - Fas ligand KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune system regulation KW - T cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009608&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Separation of tryptophan and related indoles by micellar electrokinetic chromatography with KrF laser-induced fluorescence detection. AU - Chan, K. C. AU - Muschik, G. M. AU - Issaq, H. J. JO - Journal of Chromatography JF - Journal of Chromatography Y1 - 1995/// VL - 718 IS - 1 SP - 203 EP - 210 SN - 0021-9673 AD - Chan, K. C.: SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA. N1 - Accession Number: 19961400383. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 73-22-3. Subject Subsets: Human Nutrition N2 - Micellar electrokinetic chromatography (MEKC) was applied for the separation of tryptophan and related indoles. Using a 5 mM sodium borate buffer (pH 9.2) containing 50 mM sodium dodecyl sulfate and 5% acetonitrile, 11 indoles were baseline separated in under 17 min. Most of the indoles were detected at the nM level by native fluorescence using KrF laser-induced fluorescence (LIF), which was about 100 times more sensitive than UV absorption detection at 200 nm. Preliminary results show that the MEKC-LIF with direct sample injection is a feasible method for assessing indole profiles in diluted urine and serum. KW - analytical methods KW - chromatography KW - detection KW - fluorescence KW - indoles KW - tryptophan KW - analytical techniques KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961400383&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Pursuit of new leads to antitumour and anti-HIV agents from plants. AU - Cardellina, J. H., II AU - Boyd, M. R. A2 - K Hostettmann A2 - A Marston A2 - M Maillard A2 - M Hamburger T2 - Phytochemistry of plants used in traditional medicine JO - Phytochemistry of plants used in traditional medicine JF - Phytochemistry of plants used in traditional medicine Y1 - 1995/// IS - 37 SP - 81 EP - 93 CY - Oxford; UK PB - Oxford University Press SN - 0198577753 AD - Cardellina, J. H., II: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962007857. Publication Type: Miscellaneous. Language: English. Number of References: 28 ref. KW - development KW - drug therapy KW - human immunodeficiency viruses KW - medicinal plants KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - chemotherapy KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Non-food/Non-feed Plant Products (SS200) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The characteristics that differentiate Filobasidiella depauperata from Filobasidiella neoformans. AU - Kwon-Chung, K. J. AU - Chang, Y. C. AU - Bauer, R. AU - Swann, E. C. AU - Taylor, J. W. AU - Goel, R. A2 - Boekhout, T. A2 - Samson, R. A. JO - Studies in Mycology JF - Studies in Mycology Y1 - 1995/// IS - 38 SP - 67 EP - 79 CY - Baarn; Netherlands PB - Centraalbureau voor Schimmelcultures (CBS) SN - 0166-0616 AD - Kwon-Chung, K. J.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200843. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The characteristics that differentiate F. depauperata and F. neoformans are discussed, including 18S ribosomal DNA sequences, ultrastructure of hyphal septa and nuclear division, life-cycles and biochemical characteristics. KW - identification KW - ribosomal DNA KW - taxonomy KW - techniques KW - ultrastructure KW - Cryptococcus neoformans KW - Filobasidiella KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - Filobasidiella depauperata KW - Filobasidiella neoformans KW - fungus KW - Heterobasidiomycetes - systematics and applied aspects KW - systematics KW - Taxonomy and Evolution (ZZ380) KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200843&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antifungal agents. AU - Bennett, J. E. A2 - Mandell, G. L. A2 - Bennett, J. E. A2 - Dolin, R. T2 - Mandell, Douglas and Bennett's principles and practice of infectious diseases. Volume 1. Y1 - 1995/// IS - Ed. 4 CY - New York; USA PB - Churchill Livingstone SN - 0443089353 AD - Bennett, J. E.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Health and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19961202032. Publication Type: Book chapter. Language: English. Number of References: 105 ref. Registry Number: 1397-89-3, 65-85-0, 86386-73-4, 2022-85-7, 84625-61-6, 65277-42-1, 69-72-7. Subject Subsets: Medical & Veterinary Mycology N2 - Topical and systemic antifungal agents are discussed with the emphasis on pharmacology. Agents for cutaneous use such as salicylic and benzoic acids, allylamines, azoles, morpholine derivatives and polyenes; topical agents for vaginal use; oral therapy for superficial mycoses; and treatment of deep mycoses with amphotericin B, flucytosine, ketoconazole, itraconazole and fluconazole are considered. KW - amphotericin B KW - antifungal agents KW - azoles KW - benzoic acid KW - fluconazole KW - flucytosine KW - itraconazole KW - ketoconazole KW - mycoses KW - reviews KW - salicylic acid KW - therapy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 5-fluorocytosine KW - allylamines KW - fungistats KW - polyenes KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202032&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Strongyloides stercoralis. AU - Neva, F. A2 - Farthing, M. J. G. A2 - Keusch, G. T. A2 - Wakelin, D. T2 - Enteric infection 2: intestinal helminths. JO - Enteric infection 2: intestinal helminths. JF - Enteric infection 2: intestinal helminths. Y1 - 1995/// SP - 87 EP - 105 CY - London; UK PB - Chapman & Hall Ltd SN - 0412391406 AD - Neva, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19950807177. Publication Type: Miscellaneous. Language: English. Number of References: 69 ref. KW - helminthoses KW - helminths KW - human diseases KW - strongyloidiasis KW - man KW - Rhabditida KW - Strongyloides stercoralis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - nematodes KW - parasitic worms KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807177&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antigenic variation in Giardia lamblia. AU - Nash, T. E. A2 - Boothroyd, J. C. A2 - Komuniecki, R. T2 - Molecular approaches to parasitology. Y1 - 1995/// CY - New York; USA PB - Wiley-Liss, Inc. SN - 0471103411 AD - Nash, T. E.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800031. Publication Type: Book chapter. Language: English. Number of References: 51 ref. Subject Subsets: Protozoology KW - antigenic variation KW - molecular biology KW - molecular genetics KW - parasites KW - parasitology KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800031&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Immune responses in lymphatic-dwelling filarial infections. AU - Nutman, T. B. A2 - Boothroyd, J. C. A2 - Komuniecki, R. T2 - Molecular approaches to parasitology. Y1 - 1995/// CY - New York; USA PB - Wiley-Liss, Inc. SN - 0471103411 AD - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800061. Publication Type: Book chapter. Language: English. Number of References: 48 ref. Subject Subsets: Helminthology KW - filariids KW - helminths KW - immune response KW - molecular biology KW - parasites KW - parasitology KW - man KW - onchocercidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - immunity reactions KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800061&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Regulation of cell-mediated immunity by parasites: the ups and downs of an important host adaptation. AU - Sher, A. A2 - Boothroyd, J. C. A2 - Komuniecki, R. T2 - Molecular approaches to parasitology. Y1 - 1995/// CY - New York; USA PB - Wiley-Liss, Inc. SN - 0471103411 AD - Sher, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19960800055. Publication Type: Book chapter. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology; Helminthology KW - helminths KW - molecular biology KW - parasites KW - parasitology KW - protozoa KW - invertebrates KW - animals KW - eukaryotes KW - immunoregulation KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Taxol®: science and applications. A2 - Suffness, M. T2 - Taxol®: science and applications. Y1 - 1995/// CY - Boca Raton; USA PB - CRC Press, Inc. SN - 084938382X AD - National Cancer Institute, National Insititutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19950316216. Publication Type: Book. Language: English. Registry Number: 33069-62-4. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Forestry; Forest Products N2 - This book, designed to be of interest to all those who wish to have a broad perspective on taxol research and development, discusses the supply, biology and chemistry of taxol, and the use of taxol in the treatment of breast and ovarian cancer. The book is divided into 14 chapters: (1) Discovery and development of taxol; (2) Yew and us: a brief history of the yew tree; (3) Taxus for taxol and taxoids; (4) Potential of plant cell culture for taxane production; (5) Semisynthesis of taxol and taxotere; (6) Toward the total synthesis of taxol and it analogues; (7) Biosynthesis of taxol; (8) Preclinical antitumour activity of taxanes; (9) Biopharmaceutics of paclitaxel (taxol): formulation, activity and pharmacokinetics; (10) The use of taxol in cell biology; (11) Detection and isolation; (12) Natural taxoids: structure and chemistry; (13) The medicinal chemistry of taxol; and (14) Taxol: clinical results and current issues in development. There is a subject index. KW - alkaloids KW - antineoplastic properties KW - biosynthesis KW - chemical structure KW - clinical trials KW - diterpenoid alkaloids KW - diterpenoids KW - in vitro culture KW - in vitro production KW - medicinal plants KW - medicinal properties KW - paclitaxel KW - pharmacokinetics KW - pharmacology KW - plant composition KW - synthesis KW - man KW - Taxaceae KW - Taxus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - Taxaceae KW - anti-neoplastic properties KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - taxol KW - Taxol: science and applications KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-wood Forest Products (KK540) KW - in vitro Culture of Plant Material (FF170) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950316216&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Technical advances in AIDS research in the human nervous system. A2 - Major, E. O. A2 - Levy, J. A. T2 - Technical advances in AIDS research in the human nervous system. Y1 - 1995/// CY - New York; USA PB - Plenum Publishing Corporation SN - 0306450003 AD - National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA. N1 - Accession Number: 19962001958. Publication Type: Book. Language: English. Number of References: ref. KW - acquired immune deficiency syndrome KW - brain KW - central nervous system KW - culture techniques KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - neurology KW - pathogenesis KW - proteins KW - toxins KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cerebrum KW - CNS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001958&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structural features of the large subunit rRNA expressed in Plasmodium falciparum sporozoites that distinguish it from the asexually expressed large subunit rRNA. AU - Rogers, M. J. AU - Gutell, R. R. AU - Damberger, S. H. AU - Li Jun AU - McConkey, G. A. AU - Waters, A. P. AU - McCutchan, T. F. JO - RNA JF - RNA Y1 - 1996/// VL - 2 IS - 2 SP - 134 EP - 145 AD - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970801518. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Protozoology N2 - The 5.8S and 28S rRNAs from Plasmodium falciparum that are expressed in the sporozoite stage (S gene) of the parasites' life cycle in the mosquito host were identified and compared with transcripts expressed in the red blood cells (A gene) of the vertebrate host. This completes the first set of A- and S-type nuclear-encoded rRNA genes for a Plasmodium species. Analysis of the predicted secondary structures of the 2 units showed that most differences between the A- and S-type genes occur in regions previously known to be variable. However, the predicted secondary structure of both 28S rRNAs indicated 11 positions within conserved areas that are not typical of eukaryotic rRNAs. Although the A-type gene resembled almost all eukaryotes, being atypical in only 4 of the 11 positions, the S gene is variant in 8 of the 11 positions. In 3 of these positions, the S-type gene resembles the consensus nucleotides for the 23S rRNA from Eubacteria and/or Archaea. A few differences occur in regions associated with ribosome function, in particular the GTPase site where the S-type differs in a base pair and loop from all known sequences. Further, the identification of compensatory changes at conserved points of interactions between the 5.8S-28S rRNAs indicates that transcripts from A- and S-units should not be interchangeable. KW - genes KW - molecular genetics KW - nucleotide sequences KW - parasites KW - ribosomal RNA KW - sporozoites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801518&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Application of molecular techniques to the diagnosis of microsporidial infection. AU - Fedorko, D. P. AU - Hijazi, Y. M. JO - Emerging Infectious Diseases JF - Emerging Infectious Diseases Y1 - 1996/// VL - 2 IS - 3 SP - 183 EP - 191 AD - Fedorko, D. P.: Clinical pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C-385, Bethesda, MD 20892-1508, USA. N1 - Accession Number: 19960805117. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Protozoology N2 - This short review of the diagnosis of microsporidial infection covers traditional diagnostic methods (transmission electron microscopy, light and fluorescent microscopy, cell culture, serology) and molecular techniques. KW - diagnosis KW - molecular genetics KW - parasites KW - reviews KW - man KW - Microspora KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Protozoa KW - invertebrates KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fusin - a place for HIV-1 and T4 cells to meet. AU - Dimitrov, D. S. JO - Nature Medicine JF - Nature Medicine Y1 - 1996/// VL - 2 IS - 6 SP - 640 EP - 641 AD - Dimitrov, D. S.: National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006870. Publication Type: Journal Article. Language: English. Number of References: 8 ref. KW - binding sites KW - human diseases KW - t lymphocytes KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - binding site KW - fusin KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006870&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV integrase: a novel antiviral target. AU - Craigie, R. JO - International Antiviral News JF - International Antiviral News Y1 - 1996/// VL - 4 IS - 2 SP - 30 EP - 32 SN - 0965-2310 AD - Craigie, R.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002897. Publication Type: Journal Article. Language: English. Number of References: 21 ref. KW - acquired immune deficiency syndrome KW - antiviral agents KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inhibitors KW - integration KW - molecular biology KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - integrase KW - mechanism KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002897&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Obesity and risk of renal cell cancer. AU - Chow WongHo AU - McLaughlin, J. K. AU - Mandel, J. S. AU - Wacholder, S. AU - Niwa, S. AU - Fraumeni, J. F., Jr. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1996/// VL - 5 IS - 1 SP - 17 EP - 21 SN - 1055-9965 AD - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. N1 - Accession Number: 19962007851. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition; Public Health N2 - In a population-based case-control study including 449 directly interviewed cases and 707 controls in Minnesota, USA, the risk of renal cell cancer associated with height, weight, body mass index (BMI), and frequency of weight changes was assessed. Odds ratios and 95% confidence intervals were estimated by using logistic regression models. Among women, risk increased with increasing usual BMI (P for trend <0.001). A nearly 4-fold risk was found among the 10% of women with the highest usual BMI (odds ratio = 3.8; confidence interval = 1.7-8.4). Among men, no clear trend was observed with usual weight or BMI, although the highest risk (30-50%) generally was seen among those in the upper deciles of weight or BMI. There was no clear indication that excess BMI early or late in life disproportionately affected risk. Risk also was not related to patterns of weight fluctuations or use of diet pills. This study supports previous observations linking renal cell cancer risk to increased BMI among women and suggests a weaker association in men. Given the increasing prevalence of obesity and the rising incidence of renal cell cancer in the USA, additional studies are needed to disentangle the effects of BMI from various correlates and to identify the mechanisms by which obesity affects risk. KW - body mass index KW - human diseases KW - kidney cancer KW - kidneys KW - neoplasms KW - obesity KW - risk KW - risk factors KW - Minnesota KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lake States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancer sites KW - cancers KW - fatness KW - renal cancer KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007851&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary profiles and anti-oxidants in a rural population of central Italy with a low frequency of cancer. AU - Caperle, M. AU - Maiani, G. AU - Azzini, E. AU - Conti, E. M. S. AU - Raguzzini, A. AU - Ramazzotti, V. AU - Crespi, M. JO - European Journal of Cancer Prevention JF - European Journal of Cancer Prevention Y1 - 1996/// VL - 5 IS - 3 SP - 197 EP - 206 SN - 0959-8278 AD - Caperle, M.: Section of Epidemiology, Regina Elena National Cancer Institute, Viale Regina Elena 291, 00161 Rome, Italy. N1 - Accession Number: 19961406861. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 50-81-7, 104404-69-5, 9031-37-2, 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition N2 - This descriptive, cross-sectional study reports the antioxidant activities of 736 individuals, randomly selected from residents of 2 small towns of the Latina province of Italy (an area with low frequency of cancer). The circulating levels of vitamins A, C and E, ceruloplasmin, carotenoids (lutein + zeaxanthin, lycopene, α- and β-carotene, cryptoxanthin), cholesterol, HDL cholesterol and triglycerides, as well as anthropometric measurements (skin-folds, height, weight) were evaluated. A dietary interview was also performed by means of a semi-quantitative questionnaire. All the antioxidants were above the cut-off points for normality, whereas body mass index, % fat and serum lipids were not clearly suggestive of a protected population. The data obtained could be useful to estimate the baseline values of protective microelements and to assess dietary profiles in populations following a Mediterranean diet. KW - antioxidants KW - ascorbic acid KW - blood KW - blood lipids KW - carotenoids KW - ceruloplasmin KW - diet studies KW - incidence KW - neoplasms KW - retinol KW - vitamin E KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - axerophthol KW - caeruloplasmin KW - cancers KW - tetraterpenoids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406861&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Colorectal cancer and folate status: a nested case-control study among male smokers. AU - Glynn, S. A. AU - Albanes, D. AU - Pietinen, P. AU - Brown, C. C. AU - Rautalahti, M. AU - Tangrea, J. A. AU - Gunter, E. W. AU - Barrett, M. J. AU - Virtamo, J. AU - Taylor, P. R. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1996/// VL - 5 IS - 7 SP - 487 EP - 494 SN - 1055-9965 AD - Glynn, S. A.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 211, 9000 Rockville Pike, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19971404860. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition; Public Health N2 - The relationship between folate status and colorectal cancer was examined in a case-control study nested within the Alpha-Tocopherol Beta-Carotene (ATBC) Study cohort of 29 133 male smokers in Finland, 50-69 years old, recruited between 1985 and 1988 and followed for 5-8 years. Serum folate was measured in 144 cases of colorectal cancer (91 colon, 53 rectum) occurring in 1985 through November 1993, identified from the Finnish cancer registry and 276 controls matched to cases on baseline age, clinic and time of blood collection. Baseline dietary folate was available from a food-use questionnaire for 386 of these men (92%). Conditional logistic regression modelling was used. Non-significant association was observed between serum folate and colon or rectal cancer. Although a 2-fold increase in rectal cancer risk was suggested for men with serum folate >2.9 ng/ml and those in the highest quartile of energy-adjusted folate intake, there was no evidence of a monotonic dose-response and all confidence intervals included unity. For dietary folate and colon cancer, odds ratios (OR) of 0.40 (95% confidence interval (CI), 0.16-0.96), 0.34 (95% CI, 0.13-0.88), and 0.51 (95% CI, 0.20-1.31) were obtained for the second to fourth quartiles of energy-adjusted folate intake, respectively, compared to the first (P for trend=0.15). Furthermore, men with a high-alcohol, low folate, low-protein diet were at higher risk for colon cancer than men who consumed a low-alcohol, high-folate, high-protein diet (OR, 4.79; 95% CI, 1.36-16.93). This study suggests a possible association between low folate intake and increased risk of colon cancer (but not rectal cancer). KW - alcoholic beverages KW - blood KW - colon KW - colorectal cancer KW - diet studies KW - epidemiology KW - folic acid KW - intake KW - men KW - neoplasms KW - nutrition KW - nutritional state KW - protein intake KW - rectum KW - risk KW - risk factors KW - tobacco smoking KW - vitamins KW - Europe KW - Finland KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancer sites KW - cancers KW - folacin KW - folate KW - nutritional status KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404860&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk. AU - Dorgan, J. F. AU - Longcope, C. AU - Stephenson, H. E., Jr. AU - Falk, R. T. AU - Miller, R. AU - Franz, C. AU - Kahle, L. AU - Campbell, W. S. AU - Tangrea, J. A. AU - Schatzkin, A. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1996/// VL - 5 IS - 7 SP - 533 EP - 539 SN - 1055-9965 AD - Dorgan, J. F.: Divison of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19972003758. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 53-16-7. Subject Subsets: Public Health N2 - To evaluate the relation of serum sex hormones to breast cancer risk, a prospective nested case-control study was conducted using the Breast Cancer Serum Bank (Columbia, MO, USA). This bank included serum from 3375 postmenopausal women free of cancer and not taking replacement oestrogens when they donated blood between 1977 and 1987. Of these, 71 were diagnosed subsequently with breast cancer. For each case, 2 women alive and free of cancer at the age of the case's diagnosis and matched to the case on age and on date and time of day of blood collection were selected as controls. The median age of subjects at blood collection was 62 years, and the time from blood collection to diagnosis ranged from <1 to 9.5 years, with a median of 2.9 years. Postmenopausal women with elevated serum levels of total and non-sex hormone-binding globulin-bound E2 were at an increased risk of developing breast cancer. For non-sex hormone-binding globulin-bound E2, risks were elevated 4-5 fold for women in the upper 3 quartiles relative to those in the lowest quartile. Although breast cancer was not related to oestrone or oestrone sulfate concentration, the ratio of oestrone sulfate to oestrone was significantly inversely associated with risk, suggesting that women who develop breast cancer may be less able to metabolize oestrone to its less active form. Serum testosterone was significantly positively associated with postmenopausal breast cancer; the relative risk for women in the highest vs. the lowest quartile was 6.2 (95% confidence interval, 2.0-19.0). These results support the hypothesis that prediagnostic serum oestrogens and androgens are related to the subsequent diagnosis of breast cancer in postmenopausal women. KW - blood donors KW - breast KW - breast cancer KW - diagnosis KW - estrone KW - human diseases KW - incidence KW - neoplasms KW - oestrogens KW - risk factors KW - serum KW - sex hormones KW - women KW - Missouri KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - breasts KW - cancer sites KW - cancers KW - estrogens KW - oestrol KW - oestrone KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003758&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Distribution of human leukocyte antigens in a population of black patients with human T-cell lymphotropic virus type I-associated adult T-cell leukemia/lymphoma. AU - White, J. D. AU - Johnson, J. A. AU - Nam, J. AU - Cranston, B. AU - Hanchard, B. AU - Waldmann, T. A. AU - Manns, A. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1996/// VL - 5 IS - 11 SP - 873 EP - 877 SN - 1055-9965 AD - White, J. D.: Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001178. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - The results of this pilot study indicate that black patients with adult T-cell leukaemia (ATL) may have increased frequencies of certain class I HLA when compared with a racially similar HTLV-I-positive reference population. This suggests that either these antigens may represent markers for a population at greater risk of developing ATL once infected in the process of malignant transformation or progression from the carrier state to onset of ATL. These antigens should be targeted in larger studies to confirm or refute these findings. KW - adult T-cell leukaemia KW - antigens KW - blacks KW - disease course KW - epidemiology KW - ethnic groups KW - htlv-i infections KW - malignant course KW - t lymphocytes KW - USA KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adult T-cell leukemia KW - antigenicity KW - disease progression KW - HTLV-BLV group KW - immunogens KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001178&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene therapy for AIDS. AU - Bunnell, B. A. AU - Morgan, R. A. JO - Molecules and Cells JF - Molecules and Cells Y1 - 1996/// VL - 6 IS - 1 SP - 1 EP - 12 AD - Bunnell, B. A.: Clinical Gene Therapy Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001075. Publication Type: Journal Article. Language: English. Number of References: 111 ref. N2 - The use of gene therapy for HIV-1 infection is reviewed, including the life cycle of HIV-1, nucleic acid- and protein-based gene therapy approaches. Anti-HIV gene therapy clinical trials, using transdominant negative proteins, ribozymes, antisense nucleic acids or single-chain antibodies, are discussed. KW - acquired immune deficiency syndrome KW - gene therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - therapy KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001075&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Seven-year trends in plasma low-density-lipoprotein-cholesterol in young adults: the CARDIA study. AU - Bild, D. E. AU - Jacobs, D. R. Jr. AU - Liu Kiang AU - Williams, O. D. AU - Hilner, J. E. AU - Perkins, L. L. AU - Marcovina, S. M. AU - Hulley, S. B. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1996/// VL - 6 IS - 3 SP - 235 EP - 245 SN - 1047-2797 AD - Bild, D. E.: National Heart, Lung, and Blood Institute, Bethesda, MD, USA. N1 - Accession Number: 19961409655. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - To identify determinants of recent trends in blood lipid concentrations and characterize their influence on age-related increases in LDL-cholesterol, a cohort of black and white men and women aged 18-30 years in 1985-1986, from the USA were examined. Trends were assessed by comparing participants aged 25-30 years at baseline (1985-86) with those aged 25-30 years at year 7 (2788 and 1395 subjects, respectively). LDL-cholesterol was lower among those aged 25-30 years at year 7 (5.9 to 10.2 mg/100 ml depending on race-sex group; P<0.001); weight was higher (8.3 to 12.5 lb; Pless than\0.001); Keys score was lower (-4.2 to -7.3 units; P<0.001); and use of oral contraceptives was greater (white women only, P<0.01). Among 4086 participants followed for 7 years, LDL-cholesterol changed little or decreased, despite substantial weight increases in all groups (11.6 to 19.0 lb; P<0.001). Keys scores decreased by 6.1 to 8.0 units, and use of oral contraceptives decreased (P<0.001). Declining trends in LDL-cholesterol occurred despite upward trends in weight; the decline was associated with lower fat and cholesterol intake and offset expected age-related increases in LDL-cholesterol. KW - adults KW - aging KW - blood lipids KW - body weight KW - cholesterol KW - diet KW - fats KW - food intake KW - low density lipoprotein KW - oral contraceptives KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ageing KW - United States of America KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409655&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Virus-encoded zinc fingers as targets for antiviral chemotherapy. AU - Rice, W. G. AU - Turpin, J. A. JO - Reviews in Medical Virology JF - Reviews in Medical Virology Y1 - 1996/// VL - 6 IS - 4 SP - 187 EP - 199 SN - 1052-9276 AD - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001508. Publication Type: Journal Article. Language: English. Number of References: 57 ref. N2 - A personal perspective is presented on the efforts to move the concept of retroviral zinc finger inhibitors toward practical application, and a historical perspective is provided of this emerging area of antiviral research. The clinical potential of zinc finger inhibitors in HIV-1 therapeutics is discussed. KW - antiviral agents KW - antiviral properties KW - drug targets KW - drug therapy KW - HIV infections KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - research KW - treatment KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anti-viral properties KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - other agents KW - studies KW - zinc finger inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001508&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer and comorbidity in older patients: a descriptive profile. AU - Yancik, R. AU - Havlik, R. J. AU - Wesley, M. N. AU - Ries, L. AU - Long, S. AU - Rossi, W. K. AU - Edwards, B. K. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1996/// VL - 6 IS - 5 SP - 399 EP - 412 SN - 1047-2797 AD - Yancik, R.: National Institute on Aging, National Institutes of Health, Building 31, Room 5C05, 31 Center Dr. MSC 2292, Bethesda, MD 20892-2292, USA. N1 - Accession Number: 19972002122. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health N2 - In 1992, the National Institute on Aging (NIA) and the National Cancer Institute (NCI) in the USA initiated a study to assess the prevalence of comorbid conditions in elderly patients with cancer. Seven cancer sites were selected for the study: breast, cervix, ovary, prostate, colon, stomach, and urinary bladder. This report on around 7600 patients in the study sample describes the NIA/NCI approach to developing information on comorbidity in elderly patients and addresses the chronic disease burden (comorbidity) and severity for 6 particular conditions: arthritis, chronic obstructive pulmonary disease (COPD), diabetes, gastrointestinal problems, heart-related conditions, and hypertension. Data on comorbidity were collected by abstracting information from hospital medical records. Patients were registered in 6 geographical areas of the NCI Surveillance, Epidemiology, and End Results (SEER) Program. A stratified random sample of patients aged 55 to 64, 65 to 74, and 75 years or older with the index cancers were selected. Comorbidity data were matched with data from the conventional SEER monitoring system. Analyses showed that hypertension is the most prevalent condition and is also much more common as a current management problem rather than as history for the NIA/NCI SEER Study patients. Heart conditions varied slightly in the percentage of severity reported, but percentages for all tumours remained within a range of 13 to 26% for current and past categories. A similar range was observed for arthritis, with the higher percentage seen in the current problem category. For episodic complaints (e.g., gastrointestinal problems), a medical history was more common, except for cancers that involve complaints associated with the malignancy (e.g. colon and stomach cancers and, to a lesser extent, ovarian cancer). COPD and diabetes were less prevalent. Analyses currently under way will determine the impact of a patient's comorbidity burden on the cancer continuum of diagnosis, treatment, and survival. The broad and independent effects of chronic conditions, singly and in combination, are being examined. KW - arthritis KW - bladder KW - breast KW - breast cancer KW - cardiovascular diseases KW - cervical cancer KW - cervix KW - chronic course KW - colon KW - colorectal cancer KW - diabetes KW - elderly KW - epidemiology KW - gastrointestinal diseases KW - human diseases KW - hypertension KW - morbidity KW - neoplasms KW - ovaries KW - prostate KW - respiratory diseases KW - stomach KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - aged KW - breasts KW - cancers KW - comorbidity KW - elderly people KW - high blood pressure KW - lung diseases KW - older adults KW - senior citizens KW - United States of America KW - urinary bladder KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002122&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cardiovascular risk factors and hyperinsulinemia in elderly men: the Honolulu Heart Program. AU - Burchfiel, C. M. AU - Curb, J. D. AU - Arakaki, R. AU - Abbott, R. D. AU - Sharp, D. S. AU - Rodriguez, B. L. AU - Yano, K. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1996/// VL - 6 IS - 6 SP - 490 EP - 497 SN - 1047-2797 AD - Burchfiel, C. M.: Honolulu Heart Program, National Heart, Lung and Blood Institute, 347 North Kuakini Street, Honolulu, HI 96817, USA. N1 - Accession Number: 19971402030. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Associations of cardiovascular risk factors, including several measures of adiposity, with hyperinsulinaemia were assessed in 3562 elderly (age 71-93 years) Japanese American men from the Honolulu Heart Program, Hawaii who were examined between 1991 and 1993. In addition, cardiovascular risk factors measured 25 years earlier were also examined in relation to hyperinsulinaemia. Hyperinsulinaemia was defined as fasting insulin ≥95th percentile (20 µU/ml) among the subset of subjects (n=504) who were nonobese and free of clinical diabetes and glucose intolerance. When this definition was applied to the entire population, the prevalence of hyperinsulinaemia declined cross-sectionally with age (P<0.001) from 24.2% in men aged 71-74 years to 16.4% in men aged 85-93 years. Factors having a positive and independent association with hyperinsulinaemia included body mass index (BMI), triglycerides, glucose, haematocrit, use of diabetic medication, heart rate and hypertension. The association with physical activity was negative. Triglycerides, BMI, diabetic medication, hypertension, and smoking levels measured 25 years earlier were also associated independently with hyperinsulinaemia. Associations were similar in nondiabetic subjects. 3 measures of adiposity (BMI, waist circumference and subscapular skinfold thickness) were independently related to hyperinsulinaemia cross-sectionally. However, associations involving a difference between the 80th and 20th percentiles in each adiposity measure appeared strongest for BMI (odds ratio (OR), 4.5, 95% confidence interval (CI), 3.7-5.6) and waist circumference (OR, 4.1, 95% CI, 3.3-5.1) and slightly weaker for subscapular skinfold thickness (OR, 2.1, 95% CI, 1.8-2.5). These findings suggest that features of an insulin resistance syndrome including dyslipidaemia, glucose intolerance, hypertension and obesity, assessed cross-sectionally and 25 years previously, are associated independently with hyperinsulinaemia in elderly Japanese American men. KW - adipose tissue KW - anthropometric dimensions KW - arm circumference KW - blood KW - blood pressure KW - blood sugar KW - body measurements KW - cardiovascular diseases KW - diabetes KW - heart rate KW - hyperinsulinaemia KW - hypertension KW - insulin KW - men KW - obesity KW - old age KW - resistance KW - risk factors KW - skin fold thickness KW - triacylglycerols KW - Hawaii KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Polynesia KW - Oceania KW - Pacific Islands KW - anthropometric measurements KW - blood glucose KW - fatness KW - glucose in blood KW - high blood pressure KW - hyperinsulinemia KW - triglycerides KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402030&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrition and cervical neoplasia. AU - Potischman, N. AU - Brinton, L. A. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1996/// VL - 7 IS - 1 SP - 113 EP - 126 SN - 0957-5243 AD - Potischman, N.: Nutritional Epidemiology Section, Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961410610. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Registry Number: 50-81-7, 59-30-3, 1406-18-4. Subject Subsets: Human Nutrition N2 - The relationship between nutritional factors and cervical neoplasia are reviewed under the headings: Introduction; Methodology; Ecologic studies; Retinoids; Carotenoids; Vitamin C; Vitamin E; Folate; Other nutritional factors; Summary and conclusions; Biologic plausibility; and Comment and future direction. KW - ascorbic acid KW - carotenoids KW - cervix KW - folic acid KW - neoplasms KW - nutrition KW - retinoids KW - reviews KW - vitamin E KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - folacin KW - folate KW - tetraterpenoids KW - vitamin A compounds KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410610&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutrition and lung cancer. AU - Ziegler, R. G. AU - Mayne, S. T. AU - Swanson, C. A. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1996/// VL - 7 IS - 1 SP - 157 EP - 177 SN - 0957-5243 AD - Ziegler, R. G.: Nutritional Epidemiology Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961410613. Publication Type: Journal Article. Language: English. Number of References: 161 ref. Registry Number: 57-88-5, 59-30-3. Subject Subsets: Human Nutrition N2 - The relationship between dietary factors and lung cancer are reviewed under the headings: Introduction; Vitamin A and β-carotene - a historical perspective; Vegetables, fruits and carotenoids; Recent evidence; Generalizability of effect; Strength of association and population preventive fraction; Potential mechanisms; Antioxidant micronutrients; Folic acid; Total fat, saturated and cholesterol; Correlation studies; Retrospective studies; Prospective studies; Interpretation and potential mechanisms; Independence and interrelationships of dietary effects; Intervention trials; Historical perspective; Premalignant endpoints; Malignant endpoints; Interpretation of intervention trials; and Summary and conclusions. KW - antioxidants KW - carotenoids KW - cholesterol KW - diet KW - folic acid KW - fruit KW - lungs KW - neoplasms KW - nutrition KW - reviews KW - vegetables KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - folacin KW - folate KW - tetraterpenoids KW - vegetable crops KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410613&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Stability of HIV-1 RNA in blood samples from patients with HIV-1 infection as determined by a quantitative polymerase chain reaction-based assay. AU - Shirasaka, T. AU - Kojima, E. AU - Mitsuya, H. T2 - Clinical and Diagnostic Virology JO - Clinical and Diagnostic Virology JF - Clinical and Diagnostic Virology Y1 - 1996/// VL - 7 IS - 2 SP - 121 EP - 124 SN - 0928-0197 AD - Shirasaka, T.: The Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010033. Publication Type: Correspondence. Language: English. Number of References: 15 ref. Registry Number: 63231-63-0. KW - blood KW - HIV-1 infections KW - human diseases KW - patients KW - polymerase chain reaction KW - quantitative techniques KW - RNA KW - stability KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - PCR KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010033&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiviral immunity in HIV-1 infected long-term non-progressors (LTNPs). AU - Pantaleo, G. AU - Vaccarezza, M. AU - Graziosi, C. AU - Cohen, O. J. AU - Fauci, A. S. JO - Seminars in Virology JF - Seminars in Virology Y1 - 1996/// VL - 7 IS - 2 SP - 131 EP - 138 SN - 1044-5773 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007696. Publication Type: Journal Article. Language: English. N2 - Now that the acquired immunodeficiency syndrome (AIDS) epidemic is well into its second decade, it has become evident that a small percentage (approximately 5%) of HIV-infected individuals do not experience progression of HIV disease even after several years of being infected with HIV. These individuals have been designated as 'long term non-progressors' (LTNPs). From a virologic standpoint, these LTNPs have low viral burden in mononuclear cells, but persistent virus replication as manifested by chronic and generally low levels of plasma viremia. From an immunologic standpoint, immune functions including CD8+ T-cell- and CD4+ T-cell-mediated functions are preserved. In addition, they show a vigorous humoral immune response. More importantly, lymphoid tissue structure and function are preserved in LTNPs. Despite persistent low-level virus replication and chronic stimulation of the immune system, immune activation is qualitatively and quantitatively different in LTNPs compared to that observed in HIV-infected individuals whose HIV disease has progressed. KW - disease course KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - replication KW - viral load KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - nonprogressors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007696&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Childhood exposure to magnetic fields: residential area measurements compared to personal dosimetry. AU - Friedman, D. R. AU - Hatch, E. E. AU - Tarone, R. AU - Kaune, W. T. AU - Kleinerman, R. A. AU - Wacholder, S. AU - Boice, J. D., Jr. AU - Linet, M. S. JO - Epidemiology JF - Epidemiology Y1 - 1996/// VL - 7 IS - 2 SP - 151 EP - 155 SN - 1044-3983 AD - Friedman, D. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. N1 - Accession Number: 19962008851. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - This study examined the relation between area measurements of residential magnetic fields and personal dosimetry measurements among 64 control children aged 2-14 years from the US National Cancer Institute-Children's Cancer Group's 9 state case control study of childhood leukaemia. Children spent >40% of the 24 hours of weekdays in their bedrooms, and 68% of their time at home. At-home personal dosimetry levels were highly correlated with total personal dosimetry levels in children under 9 years (Spearman correlation coefficient, R = 0.94), whereas the correlation was lower in older children (R = 0.59). For all children combined, bedroom 24-hour measurements correlated well with at-home personal dosimetry levels (R = 0.76). It is concluded that the 24-hour bedroom measurement was a useful predictor of both at-home and total personal dosimetry measurements. These data suggest, particularly for younger children, that in-home area measurements predict both current residential and current total magnetic field exposures. KW - children KW - electromagnetic radiation KW - exposure KW - leukaemia KW - measurement KW - neoplasms KW - radiation KW - toxicology KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - blood cancer KW - cancers KW - leucaemia KW - leukemia KW - metrology KW - United States of America KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008851&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of diet and antihypertensive therapy on creatinine clearance and serum creatinine concentration in the Modification of Diet in Renal Disease Study. JO - Journal of the American Society of Nephrology JF - Journal of the American Society of Nephrology Y1 - 1996/// VL - 7 IS - 4 SP - 556 EP - 566 SN - 1046-6673 AD - National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19971409329. Publication Type: Journal Article. Corporate Author: USA, Modification of Diet in Renal Disease Study Group Language: English. Number of References: 35 ref. Registry Number: 60-72-5. Subject Subsets: Human Nutrition N2 - The effect of dietary protein and antihypertensive therapy on creatinine (Cr) clearance (Ccr) and serum creatinine concentration (Pcr) was assessed in patients participating in the Modification of Diet in Renal Disease (MDRD) Study. This study compared the effects of assignment to a low vs. usual-protein diet and to a low vs. usual-blood pressure goal on the decline in these measurements over 3 years in 585 patients with baseline glomerular filtration rate (GFR) of 25-55 ml/min per 1.73 m² (study A). It also assessed correlations and associations of these measurements with each other and with protein intake, blood pressure, class of antihypertensive agents, and renal diagnosis in 840 patients with baseline GFR of 13-55 ml/min per 1.73 m² (studies A and B). In study A, the estimated mean decline in GFR at 3 years did not differ between the low and usual-protein diet groups. However, Cr clearance from tubular secretion (CTScr) declined more in the low-protein diet group (P<0.05). Consequently, the low-protein diet group had a greater decline in Ccr (P<0.05). The low-protein diet group also had a greater decline in Cr excretion (UcrV) (P<0.05). The decline in UcrV was proportionately greater than the decline in CTScr, hence the decline in the reciprocal of Pcr (1/Pcr) was less in the low-protein diet group. In study A, there was no significant difference in the decline in GFR at 3 years between the low and usual-blood pressure groups. However, there was a lesser decline in CTScr in the low blood pressure group (P<0.05). Consequently, the decline in Ccr was less in the low blood pressure group (P<0.05). There was no significant difference in UcrV between the blood pressure groups. Hence, the decline in 1/Pcr paralleled the decline in Ccr; it was less in the low blood pressure group (P<0.05). In studies A and B, correlations of rates of decline in Ccr and GFR were 0.64 and 0.79, respectively (P<0.001). Correlations of rates of decline in 1/Pcr and GFR were 0.79 and 0.85, respectively (P<0.001). In studies A and B combined, baseline GFR, CTScr and UcrV correlated significantly with protein intake (r = 0.45, 0.47 and 0.36, respectively; P<0.001), but not with blood pressure. Baseline CTScr was significantly lower in patients with polycystic kidney disease and tubulointerstitial diseases or urinary tract diseases, compared with glomerular and other diseases (P<0.05). It was also lower in patients who were taking calcium channel blockers, compared with patients not taking these agents, and in patients not taking diuretics, compared with patients taking diuretics (P<0.05). It is concluded that Cr secretion and excretion are affected by protein intake. KW - antihypertensive agents KW - blood pressure KW - creatinine KW - excretion KW - glomerular filtration rate KW - kidney diseases KW - protein intake KW - renal function KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - kidney disorders KW - kidney function KW - nephropathy KW - renal diseases KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409329&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Factors associated with disclosure of diagnosis to children with HIV/AIDS. AU - Wiener, L. S. AU - Battles, H. B. AU - Heilman, N. AU - Sigelman, C. K. AU - Pizzo, P. A. JO - Pediatric AIDS and HIV Infection JF - Pediatric AIDS and HIV Infection Y1 - 1996/// VL - 7 IS - 5 SP - 310 EP - 324 SN - 1045-5418 AD - Wiener, L. S.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972000107. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - Factors that affect the process of disclosure of AIDS and its consequences were studied in 99 parent-child dyads from the USA. Parents and HIV-infected children were interviewed and administered several standardized measures. Parental depression, family environment, social support satisfaction, socioeconomic status, child and parent gender, child's age, parental HIV serostatus and disease severity were used to predict disclosure status. Results indicated that the majority of caregivers do disclose the diagnosis to the child, usually with no ill-effects, and that age is the most significant predictor of whether or not a child has been told. KW - acquired immune deficiency syndrome KW - children KW - counselling KW - diagnosis KW - health care KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - social welfare KW - sociology KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - counseling KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - social aspects KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000107&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Drinking water nitrate and the risk of non-Hodgkin's lymphoma. AU - Ward, M. H. AU - Mark, S. D. AU - Cantor, K. P. AU - Weisenburger, D. D. AU - Correa-Villaseñor, A. AU - Zahm, S. H. JO - Epidemiology JF - Epidemiology Y1 - 1996/// VL - 7 IS - 5 SP - 465 EP - 471 SN - 1044-3983 AD - Ward, M. H.: Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Boulevard, EPN-418, Bethesda, MD 20892-7364, USA. N1 - Accession Number: 19971409267. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 14797-55-8, 50-81-7, 7727-37-9. Subject Subsets: Human Nutrition; Public Health N2 - The association between drinking water contaminated with nitrates and non-Hodgkin's Lymphoma (NHL), after accounting for dietary nitrate intake, was evaluated in 156 cases and 527 controls, in rural Nebraska, USA, between 1947 and 1979. Long-term consumption of community water with average nitrate levels in the highest quartile (≥4 mg/litre nitrate-nitrogen) was positively associated with risk (odds ratio (OR)=2.0; 95% confidence interval (CI)=1.1-3.6). Dietary nitrate, which came mainly from vegetables, was not associated with NHL risk, after adjusting for vitamin C [ascorbic acid] and carotene intakes. Persons with a lower intake of vitamin C were at slightly higher risk of developing NHL than persons whose daily intake was ≥130 mg, for all levels of intake of drinking water nitrate. Similar effects were observed for the combined effect of water nitrate and carotene intake. Nitrate levels in private wells were measured at the time of the interview for 51 cases and 150 controls but were not associated with the risk of NHL, after adjusting for pesticide use on the farm. It is concluded that long-term exposure to elevated nitrate levels in drinking water may increase the risk of NHL. KW - ascorbic acid KW - contamination KW - drinking water KW - men KW - nitrate KW - nitrates KW - nitrogen KW - non-hodgkin's lymphoma KW - toxicology KW - vegetables KW - women KW - Nebraska KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Northern Plains States of USA KW - West North Central States of USA KW - North Central States of USA KW - United States of America KW - vegetable crops KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Pesticides and Drugs (General) (HH400) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409267&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body composition in clinically stable men with HIV infection. AU - Grady, C. AU - Ropka, M. AU - Anderson, R. AU - Lane, H. C. JO - Journal of the Association of Nurses in AIDS Care JF - Journal of the Association of Nurses in AIDS Care Y1 - 1996/// VL - 7 IS - 6 SP - 29 EP - 38 AD - Grady, C.: Clinical Therapeutics Laboratory, National Institute of Nursing Research, NIH, Bethesda, MD, USA. N1 - Accession Number: 19972002230. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - Clinically stable HIV-infected men (n=106) receiving investigational antiretrovirals were recruited. Subjects were divided into 3 HIV disease severity groups by CD4+ cell count. Standard measures of body composition were assessed, as well as serum measures of visceral protein stores and kilocalorie intake. Group 1 subjects (CD4+ T cells >200) had significantly lower measures of body fat compared with Group 2 (CD4+ between 200 and 600) and Group 3 (CD4+ >600) despite adequate kilocalorie intake. Group 2 and Group 3 were not significantly different from each other. The entire cohort had significantly lower muscle mass compared to norms. It is concluded that people with advanced HIV disease have reduced muscle and fat. KW - body parts KW - clinical aspects KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - men KW - muscles KW - nutrition KW - T lymphocytes KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002230&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combination chemotherapy for advanced bilharzial bladder carcinoma. AU - Khaled, H. M. AU - El-Mawla, N. G. AU - El-Said, A. AU - Hamza, M. R. AU - Gaafar, R. AU - El-Attar, I. AU - Rabia, A. A. AU - Magrath, I. JO - Annals of Oncology JF - Annals of Oncology Y1 - 1996/// VL - 7 IS - 7 SP - 751 EP - 754 SN - 0923-7534 AD - Khaled, H. M.: Department of Medical Oncology, National Cancer Institute, Cairo, Egypt. N1 - Accession Number: 19970800396. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 57-22-7. Subject Subsets: Helminthology; Tropical Diseases N2 - Carcinoma of the bilharzial bladder, the most common cancer in Egyptian patients, is usually treated by surgery. Therapeutic combinations of identified active agents were administered in alternating cycles to patients who had not previously received chemotherapy. The study included 30 patients with inoperable disease (20), recurrent disease (5, 2 of whom subsequently developed metastases) or metastatic disease (5). There were 27 males and 3 females, with a median age of 48.5 years (range 29-65 years). Fourteen patients had squamous cell carcinoma, 12 had transitional cell carcinoma, 2 had adenocarcinoma and 2 had undifferentiated carcinoma. Chemotherapy consisted of epidoxorubicin (120 mg/sqm i.v., day 1) and vincristine (1.4 mg/sqm i.v., days 1 and 8), alternating with etoposide (100 mg/sqm i.v. infusion over 1 h, days 1 to 5) and ifosfamide (1800 mg/sqm i.v. infusion over 2 h, days 1 to 5). Mesna was given as a uroprotector at 40% of the ifosfamide dose at 0, 4 and 8 h after the ifosfamide infusion. Courses were repeated every 3-4 weeks. Among the 22 evaluable patients, 8 (36.5%) had a partial and 1 (4.5%) had a complete response, giving a response rate of 46%. Three more patients had responses that were less than a partial remission,and 6 patients showed disease stabilisation. Toxicities were tolerable and consisted mainly of myelosuppression. Results were further analysed in relation to pathological subtype, disease status at the start of chemotherapy and the delivered dose intensity. No relationship was found between any of these parameters and response to therapy. Advanced bilharzial bladder cancer appears to be relatively sensitive to combination chemotherapy, but complete remission and prolonged survival is rare in patients with advanced disease. KW - bladder KW - bladder cancer KW - bladder diseases KW - drug combinations KW - drug therapy KW - drug toxicity KW - helminths KW - human diseases KW - neoplasms KW - parasites KW - schistosomiasis KW - vincristine KW - Africa KW - Egypt KW - man KW - Schistosoma haematobium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - bilharzia KW - bilharziasis KW - cancer sites KW - cancers KW - chemotherapy KW - epidoxorubicin KW - etoposide KW - ifosfamide KW - mesna KW - Misr KW - parasitic worms KW - schistosomosis KW - Strigeida KW - urinary bladder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. AU - Kitareewan, S. AU - Burka, L. T. AU - Tomer, K. B. AU - Parker, C. E. AU - Deterding, L. J. AU - Stevens, R. D. AU - Forman, B. M. AU - Mais, D. E. AU - Heyman, R. A. AU - McMorris, T. AU - Weinberger, C. JO - Molecular Biology of the Cell JF - Molecular Biology of the Cell Y1 - 1996/// VL - 7 IS - 8 SP - 1153 EP - 1166 SN - 1059-1524 AD - Kitareewan, S.: Orphan Receptor Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. N1 - Accession Number: 19961408846. Publication Type: Journal Article. Language: English. Number of References: 88 ref. Registry Number: 1406-65-1. Subject Subsets: Human Nutrition N2 - RXR is a nuclear receptor that plays a central role in cell signalling by pairing with a host of other receptors. Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR activator. Here a unique RXR effector is described, identified from organic extracts of bovine serum by following RXR-dependent transcriptional activity. Structural analyses of material in active fractions pointed to the saturated diterpenoid phytanic acid, which induced RXR-dependent transcription at concentrations between 4 and 64 µM. Although 200 times more potent than phytanic acid, 9cRA was undetectable in equivalent amounts of extract and cannot be present at a concentration that could account for the activity. Phytenic acid, another phytol metabolite, was synthesized and stimulated RXR with a potency and efficacy similar to phytanic acid. These metabolites specifically displaced [³H]-9cRA from RXR with Ki values of 4 µM, indicating that their transcriptional effects are mediated by direct receptor interactions. Phytol metabolites are compelling candidates for physiological effectors, because their RXR binding affinities and activation potencies match their micromolar circulating concentrations. Given their exclusive dietary origin, these chlorophyll metabolites may represent essential nutrients that coordinate cellular metabolism through RXR-dependent signalling pathways. KW - cell cultures KW - chlorophyll KW - diet KW - gene expression KW - metabolites KW - plant products KW - transcription factors KW - crop products KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408846&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of dietary protein restriction on the progression of moderate renal disease in the Modification of Diet in Renal Disease Study. JO - Journal of the American Society of Nephrology JF - Journal of the American Society of Nephrology Y1 - 1996/// VL - 7 IS - 12 SP - 2616 EP - 2626 SN - 1046-6673 AD - National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19971408650. Publication Type: Journal Article. Corporate Author: USA, Modification of Diet in Renal Disease Study Group Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - 585 patients were given a low-protein diet (LPD; 0.58 g/kg daily) or a normal diet (1.3 g/kg day). The comparisons of randomized groups revealed a faster glomerular filtration rate (GFR) decline during the first 4 months of the LPD but no difference in the variability in GFR decline between the diet groups, indicating a uniform short-term effect of the LPD on GFR, probably as a result of haemodynamic adjustments. After 4 months, the mean decline in GFR in the LPD group was slower, and the variability of the rate of decline was smaller, than in the normal diet group. This suggests a greater beneficial effect of the LPD in patients with a more rapid GFR decline. Over 3 years LPD caused no significant change in mean GFR decline, but reduced the variability of the decline. Correlational analyses revealed trends similar to the comparisons of randomized groups. During the first 4 months, patients with a greater decline in protein intake (irrespective of diet group) had a greater decline in GFR; thereafter, LPD patients had a slower GFR decline. Over 3 years, there was no significant correlation between GFR decline and achieved protein intake. The relative risk of death or renal failure was 0.65 (95% CI 0.38-1.10; P=0.10) in patients assigned to the LPD group compared with the normal diet group. During follow-up, the increase in urine protein excretion was delayed in the LPD group (P=0.008) and in patients with lower achieved protein intake (P=0.005). The results provide some support for the hypothesis that dietary protein restriction slows the progression of moderate renal disease. KW - excretion KW - glomerular filtration rate KW - haemodynamics KW - kidney diseases KW - protein deprivation KW - protein intake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hemodynamics KW - kidney disorders KW - nephropathy KW - renal diseases KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408650&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation. AU - Tian, H. AU - Lempicki, R. AU - King, L. AU - Donoghue, E. AU - Samelson, L. E. AU - Cohen, D. I. JO - International Immunology JF - International Immunology Y1 - 1996/// VL - 8 IS - 1 SP - 65 EP - 74 SN - 0953-8178 AD - Tian, H.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006421. Publication Type: Journal Article. Language: English. Number of References: 62 ref. KW - CD4+ lymphocytes KW - cytopathogenicity KW - envelope proteins KW - enzymes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - killing KW - protein tyrosine kinases KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006421&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HIV causes AIDS: Koch's postulates fulfilled. AU - O'Brien, S. J. AU - Goedert, J. J. T2 - Current Opinion in Immunology JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1996/// VL - 8 IS - 5 SP - 613 EP - 618 SN - 0952-7915 AD - O'Brien, S. J.: National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972004850. Publication Type: Editorial. Language: English. Number of References: 84 refs. N2 - The debate over whether HIV causes AIDS is discussed; epidemiological association, isolation of pathogen from AIDS patients and transmission pathogenesis in animal models or in man are considered. KW - acquired immune deficiency syndrome KW - disease transmission KW - epidemiology KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004850&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The use of oral fluid to determine HIV-1 prevalence rates among men in Mexico City. AU - Rio, C. del AU - Guarner, J. AU - Izazola-Licea, J. A. T2 - AIDS JO - AIDS JF - AIDS Y1 - 1996/// VL - 10 IS - 2 SP - 233 EP - 235 SN - 0269-9370 AD - Rio, C. del: CONASIDA, National AIDS Council, National Cancer Institute, Mexico City, Mexico. N1 - Accession Number: 19962002582. Publication Type: Correspondence. Language: English. Number of References: 11 ref. KW - ELISA KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - laboratory methods KW - saliva KW - serological surveys KW - testing KW - Mexico KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - North America KW - OECD Countries KW - Threshold Countries KW - enzyme linked immunosorbent assay KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - laboratory techniques KW - salivary secretions KW - seroepidemiology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002582&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. AU - Sei, Y. AU - Whitesell, L. AU - Kustova, Y. AU - Paul, I. A. AU - Morse, H. C., III AU - Skolnick, P. AU - Basile, A. S. JO - FASEB Journal JF - FASEB Journal Y1 - 1996/// VL - 10 IS - 2 SP - 339 EP - 344 SN - 0892-6638 AD - Sei, Y.: Labroratory of Neuroscience, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19962003782. Publication Type: Journal Article. Language: English. Registry Number: 60-18-4. KW - acquired immune deficiency syndrome KW - brain KW - dementia KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunological deficiency KW - phosphorylation KW - tyrosine KW - Denmark KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - AIDS KW - cerebrum KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune deficiency KW - immunodeficiency KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003782&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. AU - Horn, V. AU - Minucci, S. AU - Ogryzko, V. V. AU - Adamson, E. D. AU - Howard, B. H. AU - Levin, A. A. AU - Ozato, K. JO - FASEB Journal JF - FASEB Journal Y1 - 1996/// VL - 10 IS - 9 SP - 1071 EP - 1077 SN - 0892-6638 AD - Horn, V.: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19961408113. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - In P19 embryonic carcinoma cells, characteristic DNA fragmentation was observed within 36 h after addition of retinoic acid (RA). Synthetic retinoids that were selective for RA receptors (RAR) were also effective in inducing apoptosis, whereas retinoid X receptor (RXR) selective ligands were without effect. The combination of RAR and RXR ligands resulted in a synergistic increase in apoptotic cell death. As with apoptosis, neuronal differentiation of P19 cells was synergistically induced by the combination of RAR and RXR ligands. Data obtained with an RAR antagonist and with P19 cells carrying a dominant negative RXR indicate that the 2 processes are receptor mediated. Together, the results indicate that retinoid-induced apoptosis and neuronal differentiation are closely coupled, and that RAR and RXR play a role in these processes as active receptors for their respective ligands. KW - apoptosis KW - carcinoma KW - cell cultures KW - cell growth KW - cells KW - development KW - differentiation KW - embryos KW - ligands KW - neoplasms KW - receptors KW - retinoic acid KW - retinoids KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cell elongation KW - tretinoin KW - vitamin A acid KW - vitamin A compounds KW - Human Reproduction and Development (VV060) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408113&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Potential heterosexual Kaposi's sarcoma-associated herpesvirus transmission in a couple with HIV-induced immunodepression and with Kaposi's sarcoma and multicentric Castleman's disease. AU - Tirelli, U. AU - Gaidano, G. AU - Errante, D. AU - Carbone, A. T2 - AIDS JO - AIDS JF - AIDS Y1 - 1996/// VL - 10 IS - 11 SP - 1291 EP - 1304 SN - 0269-9370 AD - Tirelli, U.: Division of Medical Oncology and AIDS, CRO National Cancer Institute, Aviano, Italy. N1 - Accession Number: 19972000636. Publication Type: Correspondence. Language: English. Number of References: 2 ref. KW - acquired immune deficiency syndrome KW - aetiology KW - heterosexuality KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunological deficiency KW - Kaposi's sarcoma KW - transmission KW - Human herpesvirus 8 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Rhadinovirus KW - Gammaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - Castleman's disease KW - causal agents KW - etiology KW - heterosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune deficiency KW - immunodeficiency KW - Kaposi's sarcoma-associated herpesvirus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000636&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal cancer in the pre-AIDS era. AU - Biggar, R. J. AU - Melbye, M. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 11 IS - 2 SP - 178 EP - 182 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962003481. Publication Type: Journal Article. Language: English. Number of References: 24 ref. KW - acquired immune deficiency syndrome KW - anus KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cancers KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003481&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Examining the molecular genetics of HTLV-I with an infectious molecular clone of the virus and permissive cell culture systems. AU - Derse, D. AU - Mikovits, J. AU - Waters, D. AU - Brining, S. AU - Ruscetti, F. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 12 IS - 1 SP - 1 EP - 5 AD - Derse, D.: Laboratory of Leukocyte Biology, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962006053. Publication Type: Journal Article. Language: English. Number of References: 36 ref. KW - HTLV-I infections KW - human diseases KW - molecular biology KW - pathogenesis KW - T lymphocytes KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006053&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype. AU - Bhattacharyya, D. AU - Brooks, B. R. AU - Callahan, L. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 2 SP - 83 EP - 90 SN - 0889-2229 AD - Bhattacharyya, D.: Laboratory of Structural Biology, Division of Computer Research and Technology, National Institutes of Health, Bldg. 12A, Room 2041, 12 South Drive MSC 5626, Bethesda, MD 20892-5626, USA. N1 - Accession Number: 19962003554. Publication Type: Journal Article. Language: English. Number of References: 48 ref. KW - envelope protein gp120 KW - HIV-1 infections KW - human diseases KW - pathogenesis KW - phenotypes KW - syncytia KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gp120 KW - human immunodeficiency virus type 1 KW - V3 loop KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV type 1 nef perturbs eye lens development in transgenic mice. AU - Dickie, P. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 3 SP - 177 EP - 189 SN - 0889-2229 AD - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19962003710. Publication Type: Journal Article. Language: English. Number of References: 76 ref. KW - animal models KW - eye diseases KW - eye lens KW - HIV-1 infections KW - human diseases KW - Nef protein KW - pathogenesis KW - Human immunodeficiency virus 1 KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization. AU - Ahlers, J. D. AU - Dunlop, N. AU - Pendleton, C. D. AU - Newman, M. AU - Nara, P. L. AU - Berzofsky, J. A. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 4 SP - 259 EP - 272 SN - 0889-2229 AD - Ahlers, J. D.: Molecular Immunogenetics and Vaccine Research Section Metabolism Branch, National Cancer Institute, National Institute of Health (NIH), Bethesda, MD 20892, USA. N1 - Accession Number: 19962004663. Publication Type: Journal Article. Language: English. Number of References: 72 ref. KW - adjuvants KW - HIV-1 infections KW - human diseases KW - immune response KW - immunization KW - vaccines KW - Human immunodeficiency virus 1 KW - man KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004663&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Attenuated poxvirus vectors as carriers in vaccines against human T cell leukemia-lymphoma virus type I. AU - Franchini, G. AU - Benson, J. AU - Gallo, R. AU - Paoletti, E. AU - Tartaglia, J. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 5 SP - 407 EP - 408 SN - 0889-2229 AD - Franchini, G.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972002605. Publication Type: Journal Article. Language: English. Number of References: 21 ref. N2 - The development of a vaccine against human t-cell lymphotropic virus type I using attenuated poxvirus vectors is discussed. KW - htlv-i infections KW - human diseases KW - vaccines KW - vectors KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - HTLV-BLV group KW - poxvirus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002605&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell lymphotropic virus type I infection in Barbados: results of a 20-year follow-up study. AU - Rabkin, C. S. AU - Corbin, D. O. C. AU - Felton, S. AU - Barker, H. AU - Davison, D. AU - Dearden, C. AU - Blattner, W. A. AU - Evans, A. S. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 12 IS - 5 SP - 519 EP - 522 AD - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA. N1 - Accession Number: 19962008000. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Tropical Diseases N2 - Forty-one human T-cell lymphotropic virus type I (HTLV-I)-seropositive individuals were identified among 1012 subjects with stored serum samples from a health and seroepidemiological survey conducted in Barbados in 1972. These 41 subjects plus 79 HTLV-I-seronegative household members were targeted in a follow-up study 20 years later. Sixteen seropositive subjects and 22 seronegative subjects were interviewed, examined, and phlebotomized. There were no changes in HTLV-I serostatus between the 1972 and follow-up serum samples. Three (19%) of the seropositive subjects had HTLV-I-associated disorders: two with dermatitis and one with "smouldering" adult T-cell leukemia. Neurological and immunological function was similar in HTLV-I-seropositive and HTLV-I-seronegative subjects. HTLV-I antibodies persist over many years, and the risk for seroconversion of household contacts is low. KW - adult T-cell leukaemia KW - epidemiology KW - HTLV-I infections KW - human diseases KW - infections KW - serological surveys KW - Barbados KW - Caribbean KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Windward Islands KW - Lesser Antilles KW - Antilles KW - Caribbean KW - America KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - adult T-cell leukemia KW - HTLV-BLV group KW - seroepidemiology KW - West Indies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008000&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine regulation of HIV replication induced by dendritic cell-CD4-positive T cell interactions. AU - Weissman, D. AU - Daucher, J. AU - Barker, T. AU - Adelsberger, J. AU - Baseler, M. AU - Fauci, A. S. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 9 SP - 759 EP - 767 SN - 0889-2229 AD - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007212. Publication Type: Journal Article. Language: English. Number of References: 71 ref. N2 - It has been established that human immunodeficiency virus (HIV) replication occurs throughout the course of disease in the lymphoid tissue. We have developed a model system to study the effect of cytokines and other agents on HIV replication using cocultures of DCs and T cells that reflect the cell-to-cell interactions that occur in the microenvironment of lymphoid tissue. Dendritic cells from peripheral blood, when pulsed with small amounts of HIV, induce infection in autologous, unstimulated CD4-positive T cells. Using this system, cytokines, anti-cytokine antibodies, and inhibitors of cellular activation were added to cultures and the effects on cellular proliferation and activation and HIV production were measured. Cytokines that increased T cell proliferation, such as IL-2 and IL-4, enhanced HIV replication, while the effect of IL-12 was more complex. HIV production was inhibited by blocking endogenously produced IL-2, as well as by adding IL-10, which blocks IL-2 secretion, antigen-presenting cell function, and T cell activation. Proinflammatory cytokines induced modest enhancement of viral replication in cocultures of HIV-pulsed DCs and CD4-positive T cells. Thus, using a model of HIV replication that more closely mimics the in vivo microenvironment of lymphoid tissue may allow a better analysis of the effect of cytokines and cytokine networks, as well as agents that modify immune activation on HIV replication. KW - CD4+ lymphocytes KW - cytokines KW - dendritic cells KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - interleukins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Conference summary: novel HIV therapies-from discovery to clinical proof of concept. AU - Miller, R. H. AU - Turk, S. R. AU - Black, R. J. AU - Bridges, S. AU - Sarver, N. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 10 SP - 859 EP - 865 SN - 0889-2229 AD - Miller, R. H.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962008088. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 32 ref. KW - antiviral agents KW - gene therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunotherapy KW - pathogenesis KW - research KW - therapy KW - vaccines KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - studies KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008088&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Models of HIV type 1 proviral gene expression in wild-type HIV and MLV/HIV transgenic mice. AU - Dickie, P. AU - Gazzinelli, R. AU - Chang LungJi JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 12 SP - 1103 EP - 1116 SN - 0889-2229 AD - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19962007809. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - Two proviral HIV transgenic mouse models, one bearing wild-type HIV proviral DNA and the other a modified provirus in which the viral LTRs contained the core enhancer of the Moloney murine leukemia virus (MLV), were compared. The MLV/HIV chimeric LTR, in which the MLV enhancer replaced the NF-κB-binding motifs, was transcriptionally active in human and murine cells in vitro and virus containing the chimeric LTR was replication competent in human cell cultures. Transgenic mice derived from microinjections of chimeric MLV/HIV proviral DNA transcribed HIV genes at a greater frequency and at higher levels than wild-type HIV proviral transgenic mice. MLV/HIV mice were also more apt to develop disease; wasting, periocular infections, and a degenerative myopathy characterized the most predominant phenotype. The tissue specificities of the wild-type and chimeric LTRs in transgenic mice were remarkably similar, but a significant difference was apparent in lymphoid cells. Basal level and LPS-inducible HIV gene expression occurred in peritoneal and bone marrow-derived macrophages from wild-type HIV transgenic mice. In contrast, HIV gene expression in macrophages from MLV/HIV mice was undetectable, even following LPS induction. However, cultured splenocytes from MLV/HIV mice supported HIV proviral gene transcription better than splenocytes from HIV mice, particularly after induction with LPS or anti-IgD antibody but not with concanavalin A. These data suggest that in transgenic mice, the HIV and MLV/HIV LTRs display a differential tropism for macrophages and B cells, respectively. HIV and MLV/HIV transgenic mice represent alternative models amenable to in vivo studies of HIV gene regulation in lymphoid cells, the induction of HIV-related disease and the evaluation of anti-HIV therapies. KW - animal models KW - disease course KW - gene expression KW - genetically engineered organisms KW - HIV-1 infections KW - human diseases KW - transgenic animals KW - tropisms KW - Human immunodeficiency virus 1 KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GMOs KW - human immunodeficiency virus type 1 KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007809&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mother-to-infant transmission of HIV type 1: role of major histocompatibility antigen differences. AU - Mittleman, B. B. AU - Shearer, G. M. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1996/// VL - 12 IS - 15 SP - 1397 EP - 1400 SN - 0889-2229 AD - Mittleman, B. B.: Experimental Immunology Branch, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972008909. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - antigens KW - HIV-1 infections KW - human diseases KW - immune response KW - major histocompatibility complex KW - maternal transmission KW - pregnancy KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - gestation KW - histocompatibility complex KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunogens KW - immunological reactions KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008909&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Myopathy and spontaneous Pasteurella pneumotropica-induced abscess formation in an HIV-1 transgenic mouse model. AU - Dickie, P. AU - Mounts, P. AU - Purcell, D. AU - Miller, G. AU - Fredrickson, T. AU - Chang, L. J. AU - Martin, M. A. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 13 IS - 2 SP - 101 EP - 116 AD - Dickie, P.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19972001944. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2, 63231-63-0. N2 - In an effort to augment HIV-1 gene expression in transgenic mice, an infectious proviral DNA clone was modified by deleting the two NFκ B binding sites and some adjacent upstream LTR sequences and replacing them with the core enhancer of Moloney murine leukaemia virus (MLV). Two independent lines of MLV/HIV transgenic mice were established that expressed HIV-1-specific RNA in lymphoid tissue, striated skeletal muscle, and the eye lens. Heterozygous animals from each transgenic line spontaneously developed an inflammatory disease of the eye associated with the production of copious amounts of purulent lacrimal secretions beginning at 2 weeks of age. Periorbital abscess formation became grossly apparent by 2 months of age and Pasteurella pneumotropica was cultured from the harderian glands and conjunctival surfaces of many of the MLV/HIV animals but not their nontransgenic, cohabiting littermates. This gram-negative commensal bacterium has been previously associated with a similar disease phenotype in immunocompromised (e.g., nude mice) rodent colonies. MLV/ HIV mice developed normally until 15 weeks of age, when weight loss and wasting occurred, culminating in premature death (as earlier as 6 months of age). The cachexia was associated with an initially focal and subsequently progressive myopathy, coinciding with age-related increases of HIV gene expression in muscle. KW - abscesses KW - age differences KW - animal models KW - clones KW - death KW - DNA KW - enhancers KW - eyes KW - gene expression KW - genetically engineered organisms KW - Gram negative bacteria KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - leukaemia KW - modification KW - muscular diseases KW - phenotypes KW - prematurity KW - RNA KW - secretions KW - skeleton KW - transgenic animals KW - weight losses KW - Bacteria KW - Human immunodeficiency virus 1 KW - mice KW - Pasteurella KW - Pasteurella pneumotropica KW - rodents KW - viruses KW - Bacteria KW - prokaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Proteobacteria KW - Pasteurella KW - abscess KW - bacterium KW - blood cancer KW - deoxyribonucleic acid KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - Gram-negative bacteria KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - leucaemia KW - leukemia KW - myopathy KW - ribonucleic acid KW - transgenic mice KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001944&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cigarette smoking, bacterial pneumonia, and other clinical outcomes in HIV-1 infection. AU - Burns, D. N. AU - Hillman, D. AU - Neaton, J. D. AU - Sherer, R. AU - Mitchell, T. AU - Capps, L. AU - Vallier, W. G. AU - Thurnherr, M. D. AU - Gordin, F. M. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 13 IS - 4 SP - 374 EP - 383 AD - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19972001320. Publication Type: Journal Article. Language: English. Number of References: 65 ref. N2 - Cigarette smoking has been associated with impaired immune defenses and an increased risk of certain infectious and neoplastic diseases in HIV-1 seronegative populations. The relationship between cigarette smoking and clinical outcome was studied in a prospective cohort of 3221 HIV-1-seropositive men and women enrolled in the Terry Beirn Community Programs for Clinical Research on AIDS. Differences in clinical outcomes between never, former and current cigarette smokers were assessed using proportional hazards regression analysis. After adjustment for CD4+ cell count, prior disease progression, use of antiretroviral therapy and other covariates, there was no difference between current smokers and never smokers in the overall risk of opportunistic diseases or death. However, current smokers were more likely than never smokers to develop bacterial pneumonia, oral candidosis and AIDS dementia complex. In addition, current smokers were less likely to develop Kaposi's sarcoma and several other non-respiratory tract diseases. If confirmed by other studies, these findings have important clinical implications. KW - acquired immune deficiency syndrome KW - AIDS dementia complex KW - candidosis KW - cigarettes KW - clinical aspects KW - death KW - disease course KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - mouth KW - pneumonia KW - tobacco smoking KW - USA KW - Candida KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - human immunodeficiency viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - candidiasis KW - clinical picture KW - disease progression KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001320&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Insights on the pathogenicity of human T-lymphotropic/leukemia virus types I and II. AU - Cereseto, A. AU - Mulloy, J. C. AU - Franchini, G. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 13 IS - SUP 1 SP - S69 EP - S75 AD - Cereseto, A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972000164. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Registry Number: 102524-44-7, 85898-30-2. KW - cell cycle KW - HTLV-I infections KW - human diseases KW - interleukin 2 KW - microbiology KW - pathogenesis KW - pathogenicity KW - receptors KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders. AU - Waldmann, T. A. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1996/// VL - 13 IS - SUP 1 SP - S179 EP - S185 AD - Waldmann, T. A.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972000177. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 102524-44-7, 85898-30-2. KW - adult T-cell leukaemia KW - HTLV infections KW - human diseases KW - immunotherapy KW - interleukin 15 KW - interleukin 2 KW - receptors KW - treatment KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adult T-cell leukemia KW - HTLV therapy KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000177&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. AU - Remmers, E. F. AU - Longman, R. E. AU - Du Ying AU - O'Hare, A. AU - Cannon, G. W. AU - Griffiths, M. M. AU - Wilder, R. L. JO - Nature Genetics JF - Nature Genetics Y1 - 1996/// VL - 14 IS - 1 SP - 82 EP - 85 SN - 1061-4036 AD - Remmers, E. F.: Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19960106488. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in man has been hampered by several factors, including (1) multiple interacting genetic loci contributing to susceptibility, (2) complex interactions of environmental and genetic factors, (3) genetic heterogeneity, and (4) low penetrance. Quantitative trait loci (QTLs) were mapped that control inflammatory arthritis susceptibility and/or severity in progeny of 2 inbred rat strains with significantly different susceptibilities to collagen-induced arthritis (CIA), an animal model for RA. A major susceptibility factor, Cia1, was identified on Chr 20 in the vicinity of the rat MHC. By limiting the analysis to animals with arthritis-susceptible MHC genotypes and using genome-wide QTL analytical techniques, 4 non-MHC QTLs, Cia2, 3, 4 and 5, were found on Chr 1, 4, 7 and 10, which contributed to disease severity. In addition, a QTL on Chr 8 was suggestive of linkage. KW - animal models KW - arthritis KW - biotechnology KW - collagen KW - diseases KW - gene mapping KW - genes KW - human diseases KW - immunogenetics KW - linkage KW - major histocompatibility complex KW - quantitative trait loci KW - quantitative traits KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - histocompatibility complex KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960106488&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preclinical efficacy of a glucuronoxylomannan-tetanus toxoid conjugate vaccine of Cryptococcus neoformans in a murine model. AU - Devi, S. J. N. JO - Vaccine JF - Vaccine Y1 - 1996/// VL - 14 IS - 9 SP - 841 EP - 844 SN - 0264-410X AD - Devi, S. J. N.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961201912. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A conjugate vaccine composed of the cryptococcal capsular glucuronoxylomannan covalently coupled to tetanus toxoid (GXM-TT) was constructed and evaluated. The vaccine elicited high levels of capsular antibodies in mice by active and passive immunizations and conferred 70-80% protection against a moderate challenge with 10³C. neoformans. Monitoring of serum GXM and anti-GXM antibody levels and of incidence of cryptococcal isolation from various organs of mice indicated that presence of vaccine-induced antibodies during the first 4-6 wk of infection is critical for clearance of cryptococci from various organs, for limiting serum GXM titres from reaching immunosuppressive levels and ultimately for survival. KW - antibodies KW - conjugate vaccines KW - cryptococcosis KW - efficacy KW - experimental infections KW - human diseases KW - humoral immunity KW - immunology KW - infections KW - mannans KW - vaccination KW - vaccines KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - capsule KW - european blastomycosis KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201912&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of tissue diagnosis in pulmonary involvement in pediatric human immunodeficiency virus infection. AU - Izraeli, S. AU - Mueller, B. U. AU - Ling, A. AU - Temeck, B. K. AU - Lewis, L. L. AU - Chang, R. AU - Shad, A. T. AU - Pass, H. I. AU - Pizzo, P. A. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1996/// VL - 15 IS - 2 SP - 112 EP - 116 SN - 0891-3668 AD - Izraeli, S.: Pediatric Branch, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962004413. Publication Type: Journal Article. Language: English. Number of References: 16 ref. KW - biopsy KW - children KW - diagnosis KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - lungs KW - respiratory diseases KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - lung diseases KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004413&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Specific and total carotenoid intakes among oral contraceptive and estrogen hormone users in the United States. AU - Nebeling, L. C. AU - Forman, M. R. AU - Graubard, B. I. AU - Snyder, R. A. JO - Journal of the American College of Nutrition JF - Journal of the American College of Nutrition Y1 - 1996/// VL - 15 IS - 6 SP - 608 EP - 613 SN - 0731-5724 AD - Nebeling, L. C.: National Cancer Institute, Division of Cancer Prevention and Control, Executive Plaza North, Suite 211, 6130 Executive Blvd ., MSC 7326, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19971401781. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition N2 - Carotenoid intakes were compared between hormone users and non-users in a nationally representative sample of women in the USA. Women with potentially greater risk for disease were identified. Data from the 1987 National Health Interview Survey's - Epidemiology Supplement food frequency questionnaire were linked to the United States Department of Agriculture-National Cancer Institute Carotenoid database to estimate mean total and specific carotenoid intakes. Women (n=8962) were grouped by menopausal status and classified by hormone use into premenopausal oral contraceptive users/non-users (n=5918) and postmenopausal oestrogen replacement hormone users/non-users (n=3044). Mean carotenoid intakes and standard errors were weighted using the SUDAAN software package and adjusted for potential confounding factors using multiple linear regression analysis. Compared with non-users, oral contraceptive users had lower specific carotenoid intakes. Demographic and lifestyle characteristics differed between oral contraceptive users/non-users and were examined in relation to carotenoid intakes. More oral contraceptive users than non-users were married, highly educated, drank alcoholic beverages and smoked. After adjustment for these factors in a multiple linear regression model, the associations between oral contraceptive use and carotenoid intake remained significant. Mean carotenoid intakes were not different among oestrogen hormone replacement users versus non-users. It was concluded that oral contraceptive users have lower dietary carotenoid intakes than non-users. Since oral contraceptive users smoke and drink more than non-users, and both factors are associated with lower carotenoid intakes, oral contraceptive users form a potential high risk group for disease. KW - alcoholic beverages KW - carotenoids KW - contraceptives KW - diet studies KW - hormone supplements KW - hormones KW - intake KW - menopause KW - oestrogens KW - oral contraceptives KW - replacement KW - risk KW - socioeconomic status KW - tobacco smoking KW - women KW - Usa KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - estrogens KW - tetraterpenoids KW - United States of America KW - Diet Studies (VV110) KW - Physiology of Human Nutrition (VV120) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401781&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cryptococcosis in human immunodeficiency virus-infected children. AU - Gonzalez, C. E. AU - Shetty, D. AU - Lewis, L. L. AU - Mueller, B. U. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1996/// VL - 15 IS - 9 SP - 796 EP - 800 SN - 0891-3668 AD - Gonzalez, C. E.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971200785. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - Cases of paediatric cryptococcosis were identified through a retrospective review of the hospital records of the 473 HIV-infected children prospectively monitored in the Pediatric Branch of the National Cancer Institute, Maryland, USA, during 1987-95. Four (0.85%) patients developed cryptococcosis during the study period. All patients had profound depression of the absolute CD4+ cell counts, a history of previous opportunistic infections and onset of cryptococcosis in the second decade of life. Cryptococcosis developed as a disseminated infection or a localized process of the lungs. Intermittent fever was the most common presenting manifestation. Serum cryptococcal antigen was positive in all patients and gradually declined after the institution of antifungal therapy. All patients were treated with amphotericin B with or without flucytosine as initial therapy. Suppressive therapy consisted of fluconazole with or without flucytosine. There were no deaths due to Cryptococcus neoformans. It is concluded that cryptococcosis is an infrequent yet treatable opportunistic infection of advanced paediatric AIDS that may present with subtle manifestations and warrants careful consideration in the evaluation of febrile HIV-infected children. KW - acquired immune deficiency syndrome KW - amphotericin B KW - children KW - cryptococcosis KW - fluconazole KW - flucytosine KW - generalized infections KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - lungs KW - opportunistic infections KW - predisposition KW - Maryland KW - USA KW - Cryptococcus neoformans KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - 5-fluorocytosine KW - AIDS KW - european blastomycosis KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200785&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sociodemographic, hygienic and nutritional correlates of Helicobacter pylori infection of young Bangladeshi children. AU - Clemens, J. AU - Albert, M. J. AU - Rao, M. AU - Huda, S. AU - Qadri, F. AU - Loon, F. P. L. van AU - Pradhan, B. AU - Naficy, A. AU - Banik, A. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1996/// VL - 15 IS - 12 SP - 1113 EP - 1118 SN - 0891-3668 AD - Clemens, J.: Epidemiology Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B03, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003260. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 308067-58-5. Subject Subsets: Tropical Diseases; Rural Development; Human Nutrition N2 - A random population-based survey of 257 rural Bangladeshi children aged 2-5 years and 312 children aged 6-9 years was carried out. Seropositivity for Helicobacter pylori, as manifested by the presence of serum IgG anti-H. pylori antibodies, was correlated with nutritional status of the sampled children and with sociodemographic features and access to clean water and latrine facilities among families of the children. Among children aged 2-5 years, the 123 (48%) who were infected with H. pylori were similar to the 134 non-infected children with respect to socioeconomic level, family access to tube well water and family ownership of a latrine. However, families of infected children had more persons per sleeping room in the home (3.8 vs. 3.2, P <0.05) and were more likely to be Hindu (20% vs. 10%, P <0.05). Infected children did not differ significantly from non-infected children in Z scores for weight-for-age (-2.66 vs. -2.78), weight-for-height (-1.17 vs. -1.28) or height-for-age (-3.58 vs. -3.56). Analysis of survey children aged 6-9 years also revealed similar nutritional indexes among infected vs. non-infected children. It was concluded that household crowding and behaviours that differ between Hindus and Muslims, but not lack of access to clean water and latrines, may enhance the transmission of H. pylori to rural Bangladeshi children. Although confirming the high frequency of infections in young Bangladeshi children, the findings do not support the notion that H. pylori is responsible for the high prevalence of malnutrition in this setting. KW - bacterial diseases KW - children KW - disease transmission KW - epidemiology KW - families KW - households KW - human diseases KW - hygiene KW - IgG KW - infections KW - malnutrition KW - nutritional state KW - risk factors KW - rural areas KW - rural development KW - socioeconomic status KW - socioeconomics KW - Asia KW - Bangladesh KW - Helicobacter pylori KW - man KW - Helicobacter KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - South Asia KW - Asia KW - bacterial infections KW - bacterioses KW - bacterium KW - nutritional status KW - socioeconomic aspects KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Income and Poverty (EE950) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003260&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Statistical evidence for shared transient causes of anatomically distinct birth defects. AU - Weinberg, C. R. AU - Skjærven, R. AU - Wilcox, A. J. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1996/// VL - 15 IS - 19 SP - 2029 EP - 2036 SN - 0277-6715 AD - Weinberg, C. R.: MD A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19962008646. Publication Type: Journal Article. Language: English. Number of References: 5 ref. N2 - Certain pairs of anatomically distinct birth defects co-occur in the same baby more often than predicted under independence. Such an excess might reflect either the fact that some subpopulations of parents have inherently increased risk for both, or that certain pregnancies are at increased risk for both, even within the same couple, perhaps, due to transient exposures specific to the pregnancy. The authors focus on the latter possibility in the context of a large birth registry and two relatively common types of defects, by testing the null hypothesis that within sibships the two defects occur independently. Focusing on sibships where both defects occurred, they propose a test based on the total number of 'co-incidences', sibships where both occurred in the same baby. Such a test can be carried out either with or without allowance for possible dependence of risk on birth order. Applying this to club foot and sex organ defects among sibships from the Medical Birth Registry of Norway, strong evidence for excess within-family co-incidence was found, suggesting that there are shared, time-varying (hence perhaps modifiable) causal components in their aetiology. KW - congenital abnormalities KW - disease statistics KW - human diseases KW - incidence KW - risk KW - statistical analysis KW - statistics KW - Norway KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - EFTA KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - birth defects KW - congenital malformations KW - statistical methods KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008646&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - cis-Acting sequences located downstream of the human immunodeficiency virus type 1 promoter affect its chromatin structure and transcriptional activity. AU - El-Kharroubi, A. AU - Martin, M. A. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1996/// VL - 16 IS - 6 SP - 2958 EP - 2966 SN - 0270-7306 AD - El-Kharroubi, A.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006826. Publication Type: Journal Article. Language: English. Number of References: 52 ref. KW - chromatin KW - human diseases KW - promoters KW - regulatory sequences KW - transcription KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA transcription KW - human immunodeficiency virus type 1 KW - promoter region KW - promoter sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006826&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA. AU - Clemens, K. E. AU - Piras, G. AU - Radonovich, M. F. AU - Kyeong Sook Choi AU - Duvall, J. F. AU - DeJong, J. AU - Roeder, R. AU - Brady, J. N. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1996/// VL - 16 IS - 9 SP - 4656 EP - 4664 SN - 0270-7306 AD - Clemens, K. E.: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892-5055, USA. N1 - Accession Number: 19962008541. Publication Type: Journal Article. Language: English. Number of References: 112 ref. N2 - The authors report a physical and functional interaction between Tax and the transcription factor, TFIIA. First, Tax was found to interact with the 35-kDa (α) subunit of TFIIA in the yeast two-hybrid interaction system. Two previously characterized mutants with point mutations in Tax, M32 (Y196A, K197S) and M41 (H287A, P288S), which were shown to be defective in Tax-activated transcription were unable to interact with TFIIA in this assay. Secondly, a glutathione-S-transferase (GST) affinity-binding assay showed that the interaction of holo-TFIIA with GST-Tax was 20-fold higher than that observed with either the GST-Tax M32 activation mutant or the GST control. Thirdly, a coimmunoprecipitation assay showed that in HTLV-1-infected human T lymphocytes, Tax and TFIIA were associated. Finally, TFIIA facilitates Tax transactivation in vitro and in vivo. In vitro transcription studies showed reduced levels of Tax-activated transcription in cell extracts depleted of TFIIA. In addition, transfection of human T lymphocytes with TFIIA expression vectors enhanced Tax-activated transcription of an HTLV-1 long terminal repeat-chloramphenicol acetyltransferase reporter construct. The study suggests that the interaction of Tax with the transcription factor TFIIA may play a role in Tax-mediated transcriptional activation. KW - HTLV-I infections KW - human diseases KW - Tax protein KW - transactivation KW - transcription factors KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008541&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protective immunity against HIV infection: has nature done the experiment for us? AU - Shearer, G. M. AU - Clerici, M. JO - Immunology Today JF - Immunology Today Y1 - 1996/// VL - 17 IS - 1 SP - 21 EP - 21 SN - 0167-4919 AD - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002671. Publication Type: Journal Article. Language: English. Number of References: 37 ref. KW - acquired immune deficiency syndrome KW - blood products KW - health care workers KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunity KW - immunology KW - needle sharing KW - risk factors KW - sexual behaviour KW - T lymphocytes KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - sexual behavior KW - sexual practices KW - sexuality KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002671&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosomiasis as a predisposing factor to veno-occlusive disease of the liver following allogeneic bone marrow transplantation. AU - Mahmoud, H. K. JO - Bone Marrow Transplantation JF - Bone Marrow Transplantation Y1 - 1996/// VL - 17 IS - 3 SP - 401 EP - 403 SN - 0268-3369 AD - Mahmoud, H. K.: BMT Unit, National Cancer Institute, Cairo University, Egypt. N1 - Accession Number: 19960805566. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Among 89 allogeneic bone marrow transplant recipients in Egypt, veno-occlusive disease of the liver (VOD) was diagnosed in 10 patients (11.2%). All cases (n=5) with schistosomal hepatic periportal fibrosis detected by pre-transplant ultrasonography developed severe fatal VOD in spite of normal initial liver functions and absence of portal hypertension. 3 had a history of infection with Schistosoma mansoni and 2 with S. haematobium. The incidence of VOD among patients without previous schistosomal contact was 5.95% (5 of 84). The relative risk to develop VOD was calculated to be 16.8-fold higher in patients with previous schistosomiasis. Schistosomal hepatic periportal fibrosis may thus be added to the known risk factors predisposing to the development of VOD in allogeneic transplant recipients. KW - bone marrow transplant KW - helminths KW - human diseases KW - liver KW - liver diseases KW - parasites KW - pathogenicity KW - schistosomiasis KW - Africa KW - Egypt KW - man KW - Schistosoma KW - Schistosoma haematobium KW - Schistosoma mansoni KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Schistosoma KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - bilharzia KW - bilharziasis KW - Misr KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805566&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evolving concepts of prevention and treatment of invasive fungal infections in pediatric bone marrow transplant recipients. AU - Chanock, S. J. AU - Walsh, T. J. JO - Bone Marrow Transplantation JF - Bone Marrow Transplantation Y1 - 1996/// VL - 18 IS - Suppl. 3 SP - S15 EP - S20 SN - 0268-3369 AD - Chanock, S. J.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971201896. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 53 ref. Registry Number: 1397-89-3, 86386-73-4, 2022-85-7, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - The current approach towards therapeutic options available for the prevention and treatment of fungal infections in children undergoing marrow transplantation is reviewed. Treatment with amphotericin B, imidazoles, fluconazole, itraconazole and flucytosine is discussed. KW - amphotericin B KW - antifungal agents KW - bone marrow transplant KW - children KW - drug therapy KW - fluconazole KW - flucytosine KW - fungicides KW - human diseases KW - immunocompromised hosts KW - infections KW - itraconazole KW - mycoses KW - opportunistic infections KW - predisposition KW - prevention KW - prophylaxis KW - reviews KW - therapy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 5-fluorocytosine KW - chemotherapy KW - fungistats KW - Marrow transplantation in children - current results and controversies KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201896&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Correlates and predictors of weight loss in young adults: the CARDIA study. AU - Bild, D. E. AU - Sholinsky, P. AU - Smith, D. E. AU - Lewis, C. E. AU - Hardin, J. M. AU - Burke, G. L. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1996/// VL - 20 IS - 1 SP - 47 EP - 55 SN - 0307-0565 AD - Bild, D. E.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Federal Building, Room 300, 7550 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19961401235. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition N2 - A study was conducted to examine associations of sociodemographic characteristics, behaviours, attitudes and medical factors with weight loss in a population-based biracial cohort of young adults. 4278 black and white men and women aged 18-30 years were studied in 1985-1986. Weight, height, education, income, subscapular skinfold thickness, waist and hip circumferences, medical history, smoking, physical activity, dietary energy, fat and alcohol intake, physical fitness measured by treadmill testing, self-reported dieting, history of weight loss and regain, perception of body size and belief in health consequences of overweight were recorded. Results showed that weight loss, defined as reduction of 5% or more of baseline weight, occurred in 8.9% of the cohort, ranging from 4.9% among white men who were not overweight at baseline to 21.5% among white women who were overweight. Weight loss was more common in women than men and in overweight white women than overweight black women. Although findings differed among the 4 race-sex groups, weight loss was generally associated with greater baseline fatness, lower baseline physical fitness level, self-perception of being overweight, dieting and previous weight loss and regain. Greater baseline fatness, a perception of being overweight and dieting were also associated with weight gain. Among the overweight, low baseline fitness and an increase in physical activity were the factors most consistently associated with weight loss. Weight loss in young adults varies by race, sex and body weight and is associated with a variety of behaviours and attitudes, some of which are also associated with weight gain and, thus, may be associated with weight fluctuation. KW - adults KW - diet KW - epidemiology KW - exercise KW - health KW - obesity KW - overweight KW - weight reduction KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961401235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recall of body weight and body size estimation in women enrolled in the breast cancer detection and demonstration project (BCDDP). AU - Muñoz, K. A. AU - Ballard-Barbash, R. AU - Graubard, B. AU - Swanson, C. A. AU - Schairer, C. AU - Kahle, L. L. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1996/// VL - 20 IS - 9 SP - 854 EP - 859 SN - 0307-0565 AD - Muñoz, K. A.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19961409732. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition N2 - The relationship between body mass index (BMI) and pictorial representations of body size were examined in 5807 women (33-77 years old) enrolled in the National Cancer Institute's and American Cancer Society's Breast Cancer Detection and Demonstration Project (BCDDP). Body weight and height were estimated in 1973. In 1977, a subset of the cohort recalled their usual height and weight at 10-year intervals starting at age 20. In 1987, subjects reported their usual and current weight and selected 1 of 9 pictorials best representing their body size at 15, 25, 40, 50 and +60 years old. For the cohort and among Caucasian women, Pearson correlations between recalled BMI (kg/m²) and pictorials for each decade ranged from 0.62-0.67 and was 0.80 for current BMI and current pictorial. The range of correlations between pictorials and recalled BMI for other race/ethnic groups were 0.72-0.87 (Black), 0.53-0.75 (Hispanic) and 0.28-0.87 (Asian). Among a subset of women with data on estimated BMI, recalled BMI and pictorials at specific ages, correlation between pictorials and estimated BMI was 0.75, compared to the correlation between recalled BMI and estimated BMI which was 0.89. Correlations between recalled BMI and estimated BMI were increased compared with the correlation between pictorials and estimated BMI. Therefore, estimates of body size by pictorials alone may not be appropriate for epidemiological investigations. Alternate uses of pictorials may include assessment of body weight in low literate populations or in instances where body weight is not or has not been estimated. KW - age KW - assessment KW - body measurements KW - body weight KW - estimation KW - ethnic groups KW - mammary gland neoplasms KW - self perception KW - size KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - mammary tumour KW - self concept KW - United States of America KW - Techniques and Methodology (ZZ900) KW - Human Nutrition (General) (VV100) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409732&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dual energy X-ray absorptiometry: inter-machine variability. AU - Tataranni, P. A. AU - Pettitt, D. J. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1996/// VL - 20 IS - 11 SP - 1048 EP - 1050 SN - 0307-0565 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19961411039. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition N2 - Dual-energy X-ray absorptiometry (DEXA) is rapidly becoming the method of choice for body composition measurements. Inter-machine variability was tested because large differences in body composition measurements between different DEXA machines have been reported. A comparison of total scans using 2 DEXA machines from the same manufacturer (DPX-L; Lunar Co, Madison, WI) on subjects (5 men, 5 women; 31-58 years old) was carried out. Significant differences were observed between the 2 machines for all mean values of body composition variables as a result of a systematic underestimation of bone mineral and overestimation of fat tissue by one machine compared with the other. However, the magnitude of the observed differences was small (namely bone mineral 68±57 g; percent body fat -1.7±1%). It was concluded that differences do exist in the performances of 2 DEXA machines from the same manufacturer. Although the differences reported in this study are small, emphasis should be given in pre-testing machines when multiple apparatuses are used in a study. Also, because the observed error was systematic, randomized designs are necessary when more than one DEXA machine is used in a longitudinal/intervention study. Better yet, manufacturers of DEXA machine should standardize their equipments to ensure the best consistency between machines. KW - analytical methods KW - body composition KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - Techniques and Methodology (ZZ900) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961411039&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estimating the attributable risk of residential radon among nonsmoking women: initial results and methodologic challenges. AU - Alavanja, M. C. R. AU - Brownson, R. C. AU - Benichou, J. AU - Boice, J. A2 - Hopke, P. K. JO - Environment International JF - Environment International Y1 - 1996/// VL - 22 IS - Suppl. 1 SP - S1005 EP - S1013 SN - 0160-4120 AD - Alavanja, M. C. R.: Department of Health & Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19982002656. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 10043-92-2. N2 - A population-based, case-control study of incident lung cancer among women in Missouri (USA) who were lifetime nonsmokers and long-term exsmokers was conducted in 1986-92. The study included 538 lung cancer cases and 1183 population-based, age matched controls. Information on lung cancer risk factors was obtained by interviewing cases, next-of-kin of cases and controls. Year-long radon measurements were also sought in every dwelling occupied for the previous 5-30 years. The mean radon level found in homes was 1.6 pCi/litre. This level of radon exposure is somewhat higher than that observed in the USA as a whole (mean 1.25 pCi/litre). A small nonsignificant risk was found for study subjects exposed to a median domestic radon concentration of 4 pCi/litre (25 year time-weight average). Since only a small fraction of the population is exposed at this level, it is estimated that the population attributable risk (PAR) for domestic radon is between 1 and 4% in Missouri. The growing body of residential studies has not clearly shown an elevation in lung cancer risk due to low-level, long-term radon exposure. It may be difficult to demonstrate a statistically significant increase in risk due in part to the inherent methodological difficulties associated with assessing the potential carcinogenic effect of low-level radon exposure, errors in reconstructing past radon exposures and population mobility which tends to homogenize exposures. A complementary method of radon exposure measurement, now being used in a second epidemiological evaluation of lung cancer in Missouri, which uses heirloom glass to assess actual historic cumulative dose, is discussed, and may help strengthen future studies. KW - epidemiology KW - exposure KW - human diseases KW - lung cancer KW - neoplasms KW - radon KW - risk KW - risk factors KW - women KW - Missouri KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002656&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus. AU - Spooner, K. M. AU - Lane, H. C. AU - Masur, H. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 1 SP - 15 EP - 27 SN - 1058-4838 AD - Spooner, K. M.: Critical Care Medicine, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001961. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - The results of clinical trials, meta-analyses and observational studies of antiretroviral therapy administered to HIV-1-infected patients are presented. The tables are based upon published articles and abstracts, and both the results of each study and the reviewers' interpretation are presented. KW - antiviral agents KW - clinical trials KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - therapy KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001961&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies. AU - Levine, P. H. AU - Dale, J. K. AU - Benson-Grigg, E. AU - Fritz, S. AU - Grufferman, S. AU - Straus, S. E. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 2 SP - 408 EP - 409 SN - 1058-4838 AD - Levine, P. H.: Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962008848. Publication Type: Journal Article. Language: English. Number of References: 10 ref. N2 - In 1993 a cluster of chronic fatigue syndrome (CFS) cases was investigated in a women's residential facility in the USA, which was associated with an outbreak of influenza-like illness in February 1990. Between 1990 and 1993 36 women had lived in the facility, 16 of whom reported fatigue that lasted ≤1 month during the 3-year study interval. 2 of the residents who entered the facility before 1990 already had fatigue, 5 residents stated that the onset of fatigue corresponded to the outbreak of the influenza-like illness, and 9 women described no temporal relationship between their fatigue and the influenza outbreak. In 2 of these 9 women the fatigue resolved after several weeks, but in the other 7 women it persisted. In 1993, 14 of 18 women residing in the facility were enrolled in this study, including 8 healthy women and 6 with fatigue (3 with fatigue dating to the influenza outbreak and 3 with fatigue that arose at other times). Standardized questionnaires and laboratory tests revealed that only 2 fatigued women met Centers for Disease Control and Prevention (CDC) criteria for CFS, including 1 with symptoms dating to the influenza outbreak. The results of routine blood studies and serologies for antibodies to Epstein-Barr virus and human herpesvirus type 6 were comparable among fatigued and healthy residents. It is concluded from this analysis that: the reported clustering of the cases was exaggerated; no clinical, psychological, or immunological feature that was assessed distinguished residents whose fatigue arose in association with the influenza-like illness from those in whom the fatigue was more clearly sporadic or from the healthy controls; most subjects did not meet the CDC criteria for CFS and those who did meet the criteria could not be distinguished from those who did not. KW - chronic fatigue syndrome KW - clinical aspects KW - fatigue KW - human diseases KW - immunology KW - influenza KW - outbreaks KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - clinical picture KW - flu KW - tiredness KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008848&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for fungemia in children infected with human immunodeficiency virus: a case-control study. AU - Gonzalez, C. E. AU - Venzon, D. AU - Lee, S. AU - Mueller, B. U. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 3 SP - 515 EP - 521 SN - 1058-4838 AD - Gonzalez, C. E.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961202436. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A matched case-control study was performed to define the risk factors related to the occurrence of fungaemia in HIV-positive children. During 1987-93, 22 (6.3%) of 347 HIV-positive children at the Pediatric Branch of the National Cancer Institute, Maryland, USA, developed fungaemia. Causative organisms were Candida albicans (14 episodes), C. parapsilosis (4), C. tropicalis (2), C. krusei (1), Torulopsis glabrata (4), Rhodotorula rubra (3) and Bipolaris spicifera [Cochliobolus spicifer] (1). Each of these 22 cases was matched by age and gender with 3 controls. Multiple logistic regression indicated that the best predictor of fungaemia in this population was the presence of a central venous catheter placed for >90 d (P<0.00001), followed by a group of risk factors composed of 10 independent variables adjusted for a CD4 cell count of <100/µl (P<0.045). Those variables included treatment with >3 antibiotics, treatment with >3 parenteral antibiotics, >30 d of antibiotic treatment, bacterial infections, >30 d in the hospital, hypoalbuminaemia, C3 classification of HIV infection and malnourishment. It is concluded that prolonged placement of central venous catheters is the most important risk factor for fungaemia in HIV-infected children and that the risk of fungaemia is further influenced by antibacterial therapy, catheter manipulation and host response. KW - acquired immune deficiency syndrome KW - blood KW - candidosis KW - catheters KW - children KW - fungaemia KW - hiv infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - opportunistic infections KW - predisposition KW - risk factors KW - Maryland KW - USA KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida parapsilosis KW - Candida tropicalis KW - Cochliobolus spicifer KW - man KW - Pleosporaceae KW - Rhodotorula mucilaginosa KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Cochliobolus KW - Pleosporaceae KW - Pleosporales KW - Dothideomycetes KW - Pezizomycotina KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Rhodotorula KW - Sporidiobolales KW - Microbotryomycetes KW - Pucciniomycotina KW - Basidiomycota KW - Torulopsis KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - Candida krusei KW - candidiasis KW - fungemia KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - Rhodotorula rubra KW - Torulopsis glabrata KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202436&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Asymptomatic solitary pulmonary nodules due to Cryptococcus neoformans in patients infected with human immunodeficiency virus. AU - Miller, K. D. AU - Mican, J. A. M. AU - Davey, R. T. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 4 SP - 810 EP - 812 SN - 1058-4838 AD - Miller, K. D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971202492. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Cases are reported in 3 HIV-positive men (aged 38, 44 and 42 years) from Maryland, USA, who developed solitary pulmonary nodules caused by Cryptococcus neoformans which were identified on routine surveillance chest roentgenograms. KW - asymptomatic infections KW - case reports KW - cryptococcosis KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - lungs KW - men KW - opportunistic infections KW - predisposition KW - Maryland KW - USA KW - Cryptococcus neoformans KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - european blastomycosis KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971202492&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diethylcarbamazine-induced reversal of early lymphatic dysfunction in a patient with bancroftian filariasis: assessment with use of lymphoscintigraphy. AU - Moore, T. A. AU - Reynolds, J. C. AU - Kenney, R. T. AU - Johnston, W. AU - Nutman, T. B. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 5 SP - 1007 EP - 1011 SN - 1058-4838 AD - Moore, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970801110. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 90-89-1, 1642-54-2. Subject Subsets: Helminthology; Tropical Diseases N2 - The clinical presentation of expatriates exposed to infective larvae of Wuchereria bancrofti is distinct from the chronic pathological condition seen among the native population and is similar to the findings in experimentally infected individuals who show early development of signs of lymphatic obstruction. The case of a 25-year-old Peace Corps volunteer working in Gabon is presented, who developed acute lymphatic dysfunction with leg swelling within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by using an ELISA which detected antibodies that reacted specifically to the recombinant W. bancrofti protein Wb 1.2. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with a 21-day course of diethylcarbamazine (6 mg/kg/day) followed by prophylaxis with 300 mg of diethylcarbamazine weekly reversed both the physical and lymphoscintigraphic abnormalities and prevented further recurrence. KW - anthelmintics KW - bancroftian filariasis KW - case reports KW - clinical aspects KW - diagnosis KW - diagnostic techniques KW - diethylcarbamazine KW - drug therapy KW - ELISA KW - filariasis KW - helminths KW - human diseases KW - lymph flow KW - lymphatic diseases KW - lymphatic filariasis KW - lymphatic system KW - nematode infections KW - parasites KW - pathology KW - prophylaxis KW - Africa KW - Gabon KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - chemotherapy KW - clinical picture KW - enzyme linked immunosorbent assay KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801110&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mycobacterium chelonae infection mimicking cutaneous vasculitis: case report. AU - Sran, P. K. AU - Kansupada, K. AU - Whitcup, S. M. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1996/// VL - 23 IS - 5 SP - 1189 EP - 1190 SN - 1058-4838 AD - Sran, P. K.: National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972000875. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health N2 - This paper reports the case of a 60-year-old woman from Hawaii with subcutaneous nodules due to Mycobacterium chelonae infection that were difficult to differentiate from vasculitis, panniculitis or abscess. KW - aetiology KW - bacterial diseases KW - case reports KW - epidemiology KW - human diseases KW - infection KW - infections KW - women KW - Hawaii KW - North America KW - USA KW - man KW - Mycobacterium KW - Mycobacterium chelonae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Polynesia KW - Oceania KW - Pacific Islands KW - bacterial infections KW - bacterioses KW - bacterium KW - causal agents KW - etiology KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Fatal Trichosporon pullulans breakthrough fungemia in cancer patients: report of three patients who failed on prophylaxis with itraconazole. AU - Kunová, A. AU - Godal, J. AU - Sufliarsky, J. AU - Špánik, S. AU - Kollár, T. AU - Krčméry, V., Jr. T2 - Infection JO - Infection JF - Infection Y1 - 1996/// VL - 24 IS - 3 SP - 273 EP - 274 SN - 0300-8126 AD - Kunová, A.: National Cancer Institute, Trnava, Slovakia. N1 - Accession Number: 19961201553. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 1397-89-3, 84625-61-6. Subject Subsets: Medical & Veterinary Mycology N2 - Cases are reported in a 65-yr-old woman and 63- and 55-yr-old men from Slovakia who were receiving itraconazole prophylaxis (200 or 100 mg/d) during chemotherapy through a central venous catheter for neoplastic diseases. All 3 patients were neutropenic and developed fever. Blood cultures grew T. pullulans in all 3 cases. Amphotericin B was started in all patients but 2 died of the infection after 6 and 1 d of therapy. One patient improved after amphotericin B therapy but he died 17 d later after progression of his underlying disease. KW - amphotericin B KW - antifungal agents KW - blood KW - case reports KW - catheters KW - drug therapy KW - fungaemia KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - itraconazole KW - neoplasms KW - opportunistic infections KW - predisposition KW - prophylaxis KW - Slovakia KW - man KW - Trichosporon KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - Trichosporon KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - cancers KW - chemotherapy KW - fungemia KW - fungistats KW - fungus KW - Hyphomycetes KW - Trichosporon pullulans KW - trichosporonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201553&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The potential of dietary modification to prevent cancer. AU - Greenwald, P. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1996/// VL - 25 IS - 1 SP - 41 EP - 43 SN - 0091-7435 AD - Greenwald, P.: Division of Cancer Prevention and Control, National Cancer Institute, Building 31, Room 10A52, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19961408417. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition N2 - An overview is presented. KW - diet KW - modification KW - neoplasms KW - prevention KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Health Foundation 25th anniversary symposium KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408417&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Can school health education programs make a difference? AU - Stone, E. J. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1996/// VL - 25 IS - 1 SP - 54 EP - 55 SN - 0091-7435 AD - Stone, E. J.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 2 Rockledge Center, Room 8134, 6701 Rockledge Drive, Bethesda, Maryland 20892-7936, USA. N1 - Accession Number: 19961408420. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition N2 - A brief overview is presented focusing on the Child and Adolescent Trial for Cardiovascular Health. This 8-year multicentre (96 schools in California, Louisiana, Minnesota and Texas, USA) randomized trial (1987-1994) investigated whether behaviourally orientated cardiovascular school- and family-based health programmes could produce positive changes in health habits and favourably affect the cardiovascular risk profiles of elementary school children. Interventions included classroom curricular and school environmental modifications related to food consumption, physical activity and tobacco use. Family- and home-based programmes complemented the school-based activities. KW - behaviour KW - cardiovascular diseases KW - children KW - families KW - food consumption KW - health education KW - homes KW - physical activity KW - reviews KW - risk KW - school children KW - tobacco smoking KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - American Health Foundation 25th anniversary symposium KW - behavior KW - school kids KW - schoolchildren KW - United States of America KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408420&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary retinoic acid inhibits mouse skin carcinogenesis irrespective of age at initiation. AU - Luca, L. M. de AU - Tarone, R. AU - Huynh Minh AU - Jones, C. S. AU - Chen LiChuan JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1996/// VL - 25 IS - 3 SP - 249 EP - 257 SN - 0163-5581 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20001413028. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - In the two-stage protocol of skin carcinogenesis, the carcinogen 7,12-dimethylbenz[aanthracene (DMBA) is applied to the skin of mice at around 7 weeks of age. We previously performed DMBA initiation at three weeks of age to study the effect of pharmacological (30 µg/g diet) dietary retinoic acid (RA) on skin carcinogenesis. In this study we asked whether dietary pharmacological RA is equally effective against skin carcinogenesis when mice are initiated with (DMBA) at 7 weeks of age and then subjected to weekly applications of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) or mezerein (MEZ) for 20 weeks. Similar to the 3-week initiation protocol, high dietary RA inhibited papilloma incidence and yield in MEZ- but not in TPA-promoted female SENCAR mice. In addition, carcinoma incidence and yield were decreased by high dietary RA in TPA- as well as MEZ-treated mice. These data demonstrate that the high dietary RA diet is as effective in inhibiting papilloma and carcinoma formation when the DMBA is applied at 7 weeks of age as at 3 weeks. KW - age KW - carcinogenesis KW - carcinogens KW - carcinoma KW - diets KW - neoplasms KW - papilloma KW - promoters KW - retinoic acid KW - skin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - dermis KW - papillomas KW - promoter region KW - promoter sequences KW - tretinoin KW - vitamin A acid KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413028&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Influence of dietary protein, fat, and fiber on growth, blood chemistry, and tumor incidences in Fischer 344 rats. AU - Rao, G. N. AU - Edmondson, J. AU - Hildebrandt, P. K. AU - Bruner, R. H. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1996/// VL - 25 IS - 3 SP - 269 EP - 279 SN - 0163-5581 AD - Rao, G. N.: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 20001413170. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Composition of diets may influence growth, diseases, tumour rates, and responses to chemical treatment. For two years, Fischer 344 rats were fed the NIH-07 open-formula nonpurified diet (23% protein, 5% fat, and 3.5% fibre) and nonpurified experimental diets (NTP-90, NTP-91, and NTP-92) containing lower protein and higher fat and fibre (14.6-15.3% protein, 7.2-8.5% fat, and 9.4-14% fibre) than the NIH-07 diet. Rats were evaluated for growth patterns, survival, haematology, serum chemistry, nephropathy, and tumour incidences. Growth patterns were similar in rats fed the experimental diets and in those fed the NIH-07 diet. However, in rats fed the experimental diets, the adult body weights were significantly (6-9%) lower and the survival at 110 weeks of age was significantly higher (15-20%) than in rats fed the NIH-07 diet. Lower protein content of experimental diets decreased the severity of nephropathy. Higher fat content of experimental diets appears to have decreased the incidence or delayed the development of leukaemia and associated mortality in males. Higher fibre content of experimental diets appears to have delayed the development of mammary tumours and associated mortality in females. Higher fat and/or fibre of the experimental diets decreased the incidence of pheochromocytomas in males. The lower protein and higher fat and fibre contents of the experimental diets decreased the spontaneous tumour burden in two-year studies. These studies indicate that diets for rats in long-term studies could be modified to decrease the severity of nephropathy and to decrease/delay the development of spontaneous tumours. KW - blood chemistry KW - chemical treatment KW - composition KW - diets KW - evaluation KW - fat KW - fibre KW - haematology KW - intake KW - kidney diseases KW - leukaemia KW - mortality KW - neoplasms KW - protein KW - protein content KW - protein intake KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood cancer KW - cancers KW - death rate KW - fiber KW - hematology KW - kidney disorders KW - leucaemia KW - leukemia KW - nephropathy KW - renal diseases KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reproducibility of a self-administered diet History Questionnaire administered three times over three different seasons. AU - Hartman, A. M. AU - Block, G. AU - Chan, W. AU - Williams, J. AU - McAdams, M. AU - Banks, W. L., Jr. AU - Robbins, A. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1996/// VL - 25 IS - 3 SP - 305 EP - 315 SN - 0163-5581 AD - Hartman, A. M.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 20001413173. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition N2 - The reproducibility of the widely used Health Habits and History Questionnaire (HHHQ) for estimating "usual past-year" nutrient intake was examined. The HHHQ was self-administered on three occasions during three different seasons; 68 women (average age 43 years) provided usable data for all three questionnaires in the appropriate seasons. Intraclass correlations (ICC) among the three administrations ranged from 0.56 (carotene) to 0.82 (fat as percentage of energy), with a median of 0.72. Thus, reliability was moderate to good, and season of administration/ordinality generally had little impact on ranking of individuals. The point estimates of intake of energy and a number of nutrients were higher in the first administration (winter). Except for dietary fibre and possibly carotene, most differences disappeared when adjusted for energy using a nutrient density approach, as well as using repeated-measures regression models. The higher intake in the first administration may be due more to either learning or fatigue effects rather than an effect of seasonal food availability on perceptions of usual intake. These data should be used in conjunction with validity data in the future to help evaluate the gain in precision of group means (and changes in these means) and improved estimates of odds ratios and correlations between nutrients and factors such as serum values, if a questionnaire is administered more than once. KW - analytical methods KW - carotenes KW - diets KW - fibre KW - food intake KW - health KW - intake KW - models KW - nutrients KW - questionnaires KW - ratios KW - seasonal variation KW - seasons KW - surveys KW - winter KW - analytical techniques KW - fiber KW - seasonal changes KW - seasonal fluctuations KW - Techniques and Methodology (ZZ900) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413173&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preventing AIDS among drug users: evaluating efficacy. AU - Singer, M. AU - Needle, R. JO - Journal of Drug Issues JF - Journal of Drug Issues Y1 - 1996/// VL - 26 IS - 3 SP - 521 EP - 523 AD - Singer, M.: Hispanic Health Council, National Institute on Drug Abuse, NIH, Bethesda MD, USA. N1 - Accession Number: 19972006198. Publication Type: Journal Article. Language: English. Number of References: 13 ref. N2 - Based on the lessons, both positive and negative, learned during the first wave of AIDS prevention projects targeted to drug users, the authors say that we are now in a position to move to a second wave of even more effective prevention models. Given the high rates of HIV and other life-threatening infections among drug users, especially in some regions of the country and elsewhere in the world, there is a critical need to build on the kind of projects reported in this special issue to make the "Stop AIDS" slogan of the AIDS movement a reality. KW - acquired immune deficiency syndrome KW - disease prevention KW - drug abuse KW - human diseases KW - human immunodeficiency viruses KW - injecting drug users KW - prevention KW - transmission KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - drug use KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006198&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor. AU - Turpin, J. A. AU - Schaeffer, C. A. AU - Ming Bu AU - Graham, L. AU - Buckheit, R. W. Jr. AU - Clanton, D. AU - Rice, W. G. JO - Antiviral Research JF - Antiviral Research Y1 - 1996/// VL - 29 IS - 2/3 SP - 269 EP - 277 SN - 0166-3542 AD - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Building 431T-B. P.O. Box B. Frederick, MD 21702, USA. N1 - Accession Number: 19962008295. Publication Type: Journal Article. Language: English. Number of References: 19 ref. KW - antiviral agents KW - HIV-1 infections KW - human diseases KW - proteinase inhibitors KW - replication KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - human secretory leukocyte proteinase inhibitor KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008295&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune-based therapies for treatment of HIV infection. AU - Piscitelli, S. C. AU - Minor, J. R. AU - Saville, M. W. AU - Davey, R. T., Jr. JO - Annals of Pharmacotherapy JF - Annals of Pharmacotherapy Y1 - 1996/// VL - 30 IS - 1 SP - 62 EP - 76 SN - 1042-9611 AD - Piscitelli, S. C.: Department of Pharmacy, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007945. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 145 ref. Registry Number: 9008-11-1, 308079-78-9. KW - cytokines KW - gene therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunotherapy KW - interferon KW - interleukins KW - reviews KW - tumour necrosis factor KW - vaccines KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007945&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heat loss during cold exposure in adult and aged C57BL/6J mice. AU - Shefer, V. I. AU - Talan, M. I. AU - Engel, B. T. JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1996/// VL - 31 IS - 5 SP - 597 EP - 604 SN - 0531-5565 AD - Shefer, V. I.: Gerontology Research Center, Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. N1 - Accession Number: 19971401195. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition N2 - Metabolic heat production (MHP), colonic temperature (Tco), and nonevaporative (dry) heat loss were measured in adult and aged C57BL/6J male mice during cold exposure. Dry heat loss was assessed as a differential temperature (Td) between incoming and outgoing air through the chamber for indirect calorimetry. The average Td during cold exposure normalized to surface area for adult mice was significantly higher than that for the aged mice (0.0618±0.0003°C/cm² and 0.0553±0.0005°C/cm², respectively). Linear regression analysis showed that, at the same Tco, aged mice showed lower values of Td normalized to surface area, indicating that at the same body temperature they were losing less heat than ADULT animals. It was concluded that age-related decline in cold tolerance in mice is not due to a lack of ability to reduce heat loss during cold exposure. On the contrary, AGED animals had lower heat loss in comparison with ADULT. We suggest that augmentation of heat conservation mechanisms is an adaptive response to diminishing cold-induced heat production. KW - age KW - aging KW - body temperature KW - cold stress KW - energy metabolism KW - heat loss KW - heat production KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - calorigenesis KW - thermogenesis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401195&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Losses of arachidonic acid in rat liver after alcohol inhalation. AU - Salem, N., Jr. AU - Reyzer, M. AU - Karanian, J. JO - Lipids JF - Lipids Y1 - 1996/// VL - 31 IS - SUPPL SP - S153 EP - S156 SN - 0024-4201 AD - Salem, N., Jr.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, 12501 Washington Ave., Rockville, MD 20852, USA. N1 - Accession Number: 19961404425. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 12 ref. Registry Number: 506-32-1, 64-17-5. Subject Subsets: Human Nutrition N2 - Rats were exposed to alcohol by inhalation and were fed a diet that simulated the poor diet of some alcoholics. It is hypothesized that some of the pathophysiological effects of alcohol are related to its effects on essential fatty acid metabolism and composition of vital organs. A diet that contains no 20 and 22-carbon essential fatty acids and has low levels of 18-carbon essential fatty acids was used as a dietary challenge. Addition of a second metabolic challenge, i.e., alcohol, led to loss of tissue polyunsaturates, particularly liver arachidonate. A method of cycling alcohol inhalation for 12 h/day was also presented, which was also shown to lower liver arachidonic acid content. KW - arachidonic acid KW - diet KW - essential fatty acids KW - ethanol KW - inhalation KW - liver KW - losses KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 2nd congress of the International Society for the Study of Fatty Acids and Lipids KW - eicosatetraenoic acid KW - ethyl alcohol KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404425&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians. AU - Tataranni, P. A. AU - Baier, L. J. AU - Paolisso, G. AU - Howard, B. V. AU - Ravussin, E. JO - Lipids JF - Lipids Y1 - 1996/// VL - 31 IS - SUPPL SP - S267 EP - S270 SN - 0024-4201 AD - Tataranni, P. A.: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Diabetes and Nutrition Section, 4212 N. 16th Str., Room 541-A, Phoenix, AZ 85016, USA. N1 - Accession Number: 19961404436. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 31 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - The role of lipids in the pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM) was examined in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose-fatty acid cycle. Dyslipaemia, although often associated with diabetes, did not predict NIDDM and might be associated with, or the consequence of, insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid oxidation rates and insulin resistance. KW - American Indians KW - diabetes KW - ethnic groups KW - fatty acids KW - insulin KW - lipid metabolism KW - lipids KW - pathogenesis KW - resistance KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - 2nd congress of the International Society for the Study of Fatty Acids and Lipids KW - fat metabolism KW - lipins KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404436&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The structure-activity relationship of lipoxygenase products of long-chain polyunsaturated fatty acids: effects on human platelet aggregation. AU - Karanian, J. W. AU - Kim HeeYong AU - Salem, N., Jr. JO - Lipids JF - Lipids Y1 - 1996/// VL - 31 IS - SUPPL SP - S305 EP - S308 SN - 0024-4201 AD - Karanian, J. W.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcoholsm and Alcohol Abuse, National Institutes of Health, Room 2, 12501 Washington St., Rockville, MD 20852, USA. N1 - Accession Number: 19961404444. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 26 ref. Registry Number: 506-32-1, 25167-62-8, 9029-60-1. Subject Subsets: Human Nutrition N2 - The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was examined to delineate potencies and structure-activity function. The 22-carbon n-3 fatty acids were more potent inhibitors than the n-6 lipoxygenase derivatives. Submicromolar levels of docosapentaenoic and especially docosahexaenoic hydroperoxy and hydroxy derivatives specifically antagonized the platelet aggregating effect of arachidonic acid (AA) but not that of ADP or collagen. Chain length (22-C > 20-C), double-bond position (n-3 > n-6), and double-bond number (6 > 5 > 4) influenced the degree of inhibition of AA-induced aggregation of platelets. Moreover, significant differences in potency were associated with specific structural aspects of lipoxygenase derivatives of docosahexaenoic acid as follows: functional group (OOH > OH) and positional isomer (14-OOH, 14-OH, 20-OOH > 11-OOH, 17-OOH > 10-OOH > 11-OH, 8-OOH, 7-OOH > 4-OOH). KW - aggregation KW - arachidonic acid KW - blood coagulation KW - docosahexaenoic acid KW - eicosanoids KW - in vitro KW - lipoxygenase KW - long chain fatty acids KW - platelets KW - polyenoic fatty acids KW - products KW - structure KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 2nd congress of the International Society for the Study of Fatty Acids and Lipids KW - blood platelets KW - clotting system KW - eicosatetraenoic acid KW - polyunsaturated fatty acids KW - thrombocytes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404444&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). AU - Foli, A. AU - Sogocio, K. M. AU - Anderson, B. AU - Kavlick, M. AU - Saville, M. W. AU - Wainberg, M. A. AU - Gu ZhengXian AU - Cherrington, J. M. AU - Mitsuya, H. AU - Yarchoan, R. JO - Antiviral Research JF - Antiviral Research Y1 - 1996/// VL - 32 IS - 2 SP - 91 EP - 98 SN - 0166-3542 AD - Foli, A.: Medicine Branch, National Cancer Institute, Bethesda, MD 20892-1906, USA. N1 - Accession Number: 19962009010. Publication Type: Journal Article. Language: English. Number of References: 38 ref. KW - antiviral agents KW - drug resistance KW - enzyme inhibitors KW - human immunodeficiency viruses KW - in vitro KW - mutations KW - reverse transcriptase inhibitors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009010&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Psychopharmacology in HIV-positive patients: research perspectives. AU - Vitiello, B. AU - Stover, E. S. JO - Psychopharmacology Bulletin JF - Psychopharmacology Bulletin Y1 - 1996/// VL - 32 IS - 3 SP - 293 EP - 297 AD - Vitiello, B.: National Institute of Mental Health, Office on AIDS, Rockville, MD 20857, USA. N1 - Accession Number: 19972002306. Publication Type: Journal Article; Annual report; Journal article. Language: English. Number of References: 17 ref. N2 - Psychotropic medications play an important role in the treatment of HIV-positive subjects suffering from neuropsychiatric disorders or other AIDS-related symptomatology. The quality of life of these patients can be significantly improved by the appropriate use of these agents. Various aspects of psychopharmacology that are relevant to HIV-positive patients include assessment of efficacy, tolerability, drug-interactions and effects on cognition. These topics need further investigation and require focused research efforts. This report highlights current research needs and presents specific recommendations that emerged at a recent meeting on psychopharmacology for HIV-positive patients organized by the National Institute of Mental Health (NIMH), Maryland, USA.Editorial Comment:This paper reviews the state-of-the-art in psychopharmacology research in HIV infection and makes a number of suggestions for increasing our research data base in this important area of treatment research. KW - acquired immune deficiency syndrome KW - drug therapy KW - guidelines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - patients KW - psychosocial aspects KW - research KW - sociology KW - treatment KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - neuropsychiatry KW - recommendations KW - social aspects KW - studies KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats. AU - Su XinZhuan AU - Wellems, T. E. JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1996/// VL - 33 IS - 3 SP - 430 EP - 444 SN - 0888-7543 AD - Su XinZhuan: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA. N1 - Accession Number: 19960804366. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Simple sequence length polymorphisms (SSLPs) were investigated for use as markers for genetic studies of Plasmodium falciparum. Of 507 simple sequence repeats identified from P. falciparum sequences in GenBank and a genomic DNA library, 224 were tested for polymorphisms using polymerase chain reaction assays. This yielded a set of 188 that showed SSLPs among different parasite lines, of which 116 were assigned to previously mapped chromosome linkage groups. Features of the SSLPs are consistent with the view that malaria parasites evolved from algal-like ancestors. KW - chromosome maps KW - chromosomes KW - DNA libraries KW - evolution KW - genetic markers KW - genetic polymorphism KW - genetics KW - genome analysis KW - linkage KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804366&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Granulocyte-macrophage colony-stimulating factor and interferon-γ prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae. AU - Roilides, E. AU - Blake, C. AU - Holmes, A. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1996/// VL - 34 IS - 1 SP - 63 EP - 69 SN - 0268-1218 AD - Roilides, E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200831. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The effect of dexamethasone (DEX) on superoxide anion (O2-) release and damage caused by elutriated human monocytes (EHM) on unopsonized hyphae of A. fumigatus were investigated. In addition, the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-γ (IFN-γ) on these functions of DEX-treated EHM were also studied. Treatment of EHM with concn of DEX in the range 5-500 nM (1.4-140 ng/ml) for 48 h suppressed O2- release in response to phorbol myristate acetate in a dose-dependent fashion. Similarly, DEX significantly suppressed hyphal damage caused by EHM as measured by colorimetric MTT assay. Both GM-CSF (5 mg/ml) and IFN-γ (1.2 ng/ml) added at day 0 to the EHM together with DEX (500 nM) significantly enhanced O2- release and percentage hyphal damage, preventing the DEX-induced suppression of EHM function. GM-CSF and IFN-γ prevented the deleterious effects of DEX on antifungal activity of EHM against Aspergillus, suggesting a potential therapeutic role in patients at risk for or suffering from invasive aspergillosis. KW - colony stimulating factor KW - corticoids KW - cytokines KW - immune response KW - immunology KW - immunosuppression KW - immunotherapy KW - monocytes KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - corticosteroids KW - fungus KW - Hyphomycetes KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200831&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of hepatic and renal P4502E1 of neonatal rats exposed translactationally to ethanol. AU - Chhabra, S. K. AU - Perella, C. AU - Anderson, L. M. JO - Food and Chemical Toxicology JF - Food and Chemical Toxicology Y1 - 1996/// VL - 34 IS - 5 SP - 469 EP - 476 SN - 0278-6915 AD - Chhabra, S. K.: Perinatal Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, SAIC-Frederick, Frederick, MD 21702, USA. N1 - Accession Number: 19970400393. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9035-51-2, 64-17-5. Subject Subsets: Dairy Science; Human Nutrition N2 - The effect of maternal ethanol intake during lactation on neonatal cytochrome P4502E1 was investigated in Sprague-Dawley rats. Mother rats were exposed to 15% (v/v) ethanol in drinking water from day 1 of lactation to 4, 7 or 14 days postpartum. Hepatic and renal N-nitrosodimethylamine (NDMA) demethylase activities were increased (P<0.01), an activity of cytochrome P4502E1, in lactating rats given ethanol in drinking water. NDMA demethylase activity also increased (P<0.01) in the livers of 7- and 14-day old female and male rat pups and in the kidneys of 7- and 14-day female and 14-day male rat pups exposed to ethanol through the transmammary route. Cytochrome P4502E1 protein content, assayed by immunoblotting, increased in the maternal liver and kidney of all groups consuming ethanol. Cytochrome P4502E1 protein content increased in the livers of 7- and 14-day old male and female and in the kidneys of 14-day female rat pups exposed translactationally to ethanol. No effect of ethanol on enzyme activity or protein content of cytochrome P4502E1 was observed in the liver or kidney of 4-day-old rat pups. Results demonstrate the translactational effect of ethanol on neonatal cytochrome P4502E1, which is involved in the metabolism of many low molecular weight xenobiotics, and indicate the possibility of alterations occurring in the kinetics of neonatal drug and xenobiotic metabolism and also in processes connected with perinatal carcinogenesis. KW - activity KW - cytochrome p-450 KW - enzymes KW - ethanol KW - intake KW - kidneys KW - lactation KW - liver KW - progeny KW - proteins KW - rat feeding KW - rat milk KW - young animals KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ethyl alcohol KW - rat lactation KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) KW - Milk and Dairy Produce (QQ010) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970400393&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Improved plaque assays for Rickettsia prowazekii in Vero76 cells. AU - Policastro, P. F. AU - Peacock, M. G. AU - Hackstadt, T. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1996/// VL - 34 IS - 8 SP - 1944 EP - 1948 SN - 0095-1137 AD - Policastro, P. F.: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19970500180. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Typhus group rickettsiae, including R. prowazekii and R. typhi, produce visible plaques on primary chick embryo fibroblasts and low-passage mouse embryo fibroblasts but do not form reproducible plaques on continuous cell culture lines. The authors tested medium overlay modifications for plaque formation of typhus group rickettsiae on the continuous fibroblast cell line Vero76. A procedure involving primary overlay with medium at pH 6.8, which was followed 2-3 days later with secondary overlay at neutral pH containing 1 µg of emetine per ml and 20 µg of NaF per ml, resulted in visible plaques at 7-10 days postinfection. A single-step procedure involving overlay with medium containing 50 ng of dextran sulfate per ml also resulted in plaque formation within 8 days postinfection. These assays represent reproducible and inexpensive methods for evaluating the infectious titres of typhus group rickettsiae, cloning single plaque isolates, and testing the susceptibilities of rickettsiae to antibiotics. KW - assays KW - cell culture KW - cell lines KW - culture techniques KW - fibroblasts KW - Rickettsia canadensis KW - Rickettsia prowazekii KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - plaque assays KW - plaque formation KW - Rickettsia canada KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500180&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. AU - Schwan, T. G. AU - Schrumpf, M. E. AU - Hinnebusch, B. J. AU - Anderson, D. E., Jr. AU - Konkel, M. E. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1996/// VL - 34 IS - 10 SP - 2483 EP - 2492 SN - 0095-1137 AD - Schwan, T. G.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19970501357. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Public Health N2 - Serological confirmation of tick-borne relapsing fever is based on either an immunofluorescence assay or an ELISA using whole cells or sonicated Borrelia hermsii as the antigen. However, antigenic variability of this bacterium's outer surface proteins and antigens shared with the Lyme disease spirochaete (B. burgdorferi), may cause both false-negative and false-positive results when testing sera of patients suspected to have either relapsing fever or Lyme disease. To develop a specific serological test for relapsing fever, the authors created a genomic DNA library of B. hermsii, screened transformed Escherichia coli cells for immunoreactivity with high-titred (≥1:2048) human anti-B. hermsii antiserum, and selected an immunoreactive clone (pSPR75) expressing a 39-kDa protein. DNA sequencing, subcloning and serum adsorption experiments identified the immunoreactive protein as a homologue of GlpQ, a glycerophosphodiester phosphodiesterase identified previously in E. coli, Haemophilus influenzae and Bacillus subtilis. Serum samples from humans and mice infected with Borrelia hermsii or other species of relapsing fever spirochaetes contained antibodies recognizing GlpQ, whereas serum samples from Lyme disease and syphilis patients were nonreactive. KW - antigens KW - clones KW - diagnosis KW - diagnostic techniques KW - DNA KW - enzymes KW - human diseases KW - immunodiagnosis KW - Lyme disease KW - proteins KW - relapsing fever KW - tickborne relapsing fever KW - Borrelia KW - Borrelia burgdorferi KW - Borrelia hermsii KW - Escherichia coli KW - man KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - bacterium KW - Borreia hermsii KW - deoxyribonucleic acid KW - E. coli KW - immunogens KW - lyme borreliosis KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of Chiron HIV-1/HIV-2 recombinant immunoblot assay. AU - Kline, R. L. AU - McNairn, D. AU - Holodniy, M. AU - Mole, L. AU - Margolis, D. AU - Blattner, W. AU - Quinn, T. C. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1996/// VL - 34 IS - 11 SP - 2650 EP - 2653 SN - 0095-1137 AD - Kline, R. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19982002240. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - In a study to determine the reliability, sensitivity, and specificity of the Chiron RIBA HIV-1/HIV-2 Strip ImmunobVV200lot Assay (RIBA HIV-1/2 SIA) for confirmation of human immunodeficiency virus type 1 (HIV-1) and HIV-2 antibodies, 1,263 serum samples from various populations in the United States, Caribbean, Africa, India, and Thailand were evaluated by RIBA HIV-1/2 SIA, and the results were compared with those obtained by an HIV-1 Western blot (immunoblot) assay. All sera were tested by HIV enzyme immunoassay, RIBA HIV-1/2 SIA, and Western blotting. Samples with discrepant results were further tested by an HIV-1 and/or HIV-2 immunofluorescent-antibody assay and HIV-1 p24 antigen assay. The RIBA HIV-1/2 SIA detected all 17 HIV-1 and HIV-2 dually reactive serum samples, all 215 HIV-2-positive serum samples, and 480 of 481 HIV-1-positive serum samples for a sensitivity of 99.8%. Of 548 negative samples, 523 were RIBA HIV-1/2 SIA negative, for a specificity of 95.4%, with 22 (4%) samples interpreted as indeterminate and 3 (0.6%) interpreted as falsely positive. Western blotting detected 391 of 548 negative samples (specificity, 71.4%), with 152 (27.7%) samples interpreted as indeterminate and 5 (0.9%) interpreted as falsely positive. In conclusion, the RIBA HIV-1/2 SIA had a sensitivity comparable to that of Western blotting and could discriminate HIV-1 from HIV-2 in one blot, providing a cost advantage. Because of its high degree of specificity, the RIBA HIV-1/2 SIA further reduced the number of indeterminate results found by Western blotting, providing a more accurate means of assessing seronegative individuals. KW - evaluation KW - recombinant immunoblot assay KW - RIBA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002240&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diverse patterns of recognition of hepatitis C virus core and nonstructural antigens by antibodies present in Egyptian cancer patients and blood donors. AU - Attia, M. A. M. AU - Zekri, A. R. N. AU - Goudsmit, J. AU - Boom, R. AU - Khaled, H. M. AU - Mansour, M. T. AU - Wolf, F. de AU - Alam El-Din, H. M. AU - Sol, C. J. A. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1996/// VL - 34 IS - 11 SP - 2665 EP - 2669 SN - 0095-1137 AD - Attia, M. A. M.: Virology and Immunology, National Cancer Institute, University of Cairo, Cairo, Egypt. N1 - Accession Number: 19972000505. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases N2 - Serum samples from 429 cancer patients, 82 unpaid blood donors, and 74 paid blood donors were tested for hepatitis C virus (HCV) markers using 2 commercially available enzyme immunoassays (EIAs). 229/429 (53.4%) cancer patients were positive by the 2 EIAs. 34/156 (21.8%) of the blood donors were positive by the EIAs, with a higher prevalence among paid blood donors (20/74; 27%) compared with that among the unpaid blood donors (14/82; 17%). EIA-positive sera were tested for confirmation of the results in an immunoblot assay (LiaTek) in which reactivities to 4 synthetic peptides representing the HCV core protein and 2 synthetic peptides representing nonstructural proteins 4 and 5 were measured. Of 243 first and/or second EIA-positive samples from cancer patients, 188 (77.2%) were confirmed to be positive in the synthetic peptide immunoblot. 33/35 (94.3%) blood donor samples were confirmed to be positive. A great diversity in reactivity patterns was seen. However, all sera from the group of paid blood donors were exclusively reactive to core peptides 1 and 2. A subset of LiaTek assay-positive samples were tested by the four-antigen RIBA-2 assay. The sera from the paid blood donors were all nonreactive. A subset of the LiaTek-positive sera was analysed for the presence of the HCV genome by reverse transcriptase-PCR. 11 of the 20 serum samples with reactivity to LiaTek core peptides 1 and 2 only were HCV reverse transcriptase-PCR positive, as were the majority of the sera with other reactivity patterns by the LiaTek assay. The results confirm the very high prevalence of HCV infection in Egypt, and also indicate that there is circulating in Egypt, particularly in the group of blood donors paid for their donation, an HCV variant which elicits an immune response that is not detected by the RIBA-2 assay. KW - antibodies KW - antigens KW - blood donors KW - detection KW - diagnosis KW - disease markers KW - disease prevalence KW - diversity KW - enzyme immunoassay KW - epidemiology KW - hepatitis C KW - human diseases KW - neoplasms KW - patients KW - seroprevalence KW - Asia KW - Egypt KW - hepatitis c virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - antigenicity KW - cancers KW - immunogens KW - Misr KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000505&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long PCR and its application to hepatitis viruses: amplification of hepatitis A, hepatitis B, and hepatitis C virus genomes. AU - Tellier, R. AU - Bukh, J. AU - Emerson, S. U. AU - Miller, R. H. AU - Purcell, R. H. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1996/// VL - 34 IS - 12 SP - 3085 EP - 3091 SN - 0095-1137 AD - Tellier, R.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19972001142. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - In this study virtually the entire genomes of hepatitis A virus, hepatitis B virus, and hepatitis C virus were amplified by using the recently described technique of long PCR. In order to do this, it was first demonstrated, using the λ phage, that long PCR can be made highly sensitive and that the sensitivity can be further enhanced by nested long PCR. Using tobacco mosaic virus as a model, it was also shown that a reverse transcriptase reaction can be linked to a long PCR, enabling the nearly full-length amplification of the genomes of RNA viruses. These techniques were then applied to serial dilutions of titrated stocks of well-characterized strains of hepatitis A, B, and C viruses. The nearly full-length sequence of each of these viruses was amplified from a small number of viral genomes, demonstrating the sensitivity of the process. KW - amplification KW - genes KW - genomes KW - human diseases KW - molecular biology KW - polymerase chain reaction KW - viral diseases KW - viral hepatitis KW - hepatitis A virus KW - hepatitis B virus KW - hepatitis C virus KW - man KW - Hepatovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - Hepacivirus KW - Flaviviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - PCR KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001142&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10. AU - Mock, B. A. AU - Liu LiMin AU - Paslier, D. le AU - Huang Shi JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1996/// VL - 37 IS - 1 SP - 24 EP - 28 SN - 0888-7543 AD - Mock, B. A.: National Cancer Institute, National Institutes of Health, Building 37, Room 2B08, 37 Convent Drive, MSC4255, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19970100564. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology N2 - Blimp1 restriction fragment length polymorphisms (RFLP) between BALB/cAnPt mice and Mus spretus were identified using a human BLIMP1 probe. A haplotype analysis of the RFLP in (BALB/cAnPt ×M. spretus) × BALB/cAnPt mice showed that Blimp1 was located on chromosome 10 approximately 14 cM distal to Myb. KW - B lymphocytes KW - biotechnology KW - gene mapping KW - linkage KW - maturation KW - transcription KW - transcription factors KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - B cells KW - B lymphocyte maturation promoting transcription factor KW - DNA transcription KW - maturation promoting KW - synteny KW - tumour suppressors KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970100564&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method. AU - Ikewaki, K. AU - Zech, L. A. AU - Brewer, B., Jr. AU - Rader, D. J. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1996/// VL - 37 IS - 2 SP - 399 EP - 407 SN - 0022-2275 AD - Ikewaki, K.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961403257. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - ApoA-II is a major apolipoprotein constituent of HDL and may play an important role in lipoprotein metabolism and predisposition to atherosclerosis. Previous radiotracer kinetic studies have suggested that the metabolism of apoA-II in man may be different than the metabolism of apoA-I, the major HDL apolipoprotein. In the present study, an endogenous labelling technique using stable isotopically labelled amino acids was used to study apoA-II metabolism and compared the results to those obtained by a simultaneous exogenous radiotracer labelling method. 7 subjects with HDL cholesterol levels ranging from 9 to 93 mg/100 ml and apoA-II levels from 13 to 60 mg/100 ml were investigated in this study. [13C6]phenylalanine and 131I-labelled apoA-II were simultaneously administered as a primed-constant infusion and a bolus injection, respectively. In the endogenous labelling study, plateau tracer/tracee ratios of VLDL apoB-100 were used as estimates for the precursor pool tracer-tracee ratios for apoA-II synthesis. Residence times of apoA-II using these 2 independent methods were found to be highly correlated (r = 0.973, P<0.0002). These results indicate that the endogenous labelling of apoA-II using stable isotopically labelled amino acids is a reasonable alternative to the conventional exogenous radiotracer labelling method for the investigation of apoA-II turnover. However, under the conditions of this experimental design and modelling strategy, the apoA-II residence times as determined by endogenous labelling were significantly longer (mean 5.33 days) than by exogenous radiotracer (mean 4.65 days). This suggests that apoA-II turnover may be even slower than believed based on radiotracer studies, and further supports the concept that HDL containing apoA-II are metabolized differently than HDL without apoA-II. KW - apolipoproteins KW - atherosclerosis KW - isotopes KW - kinetics KW - tracer techniques KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - Physiology of Human Nutrition (VV120) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403257&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. AU - Zha HongBin AU - Remmers, E. F. AU - Szpirer, C. AU - Szpirer, J. AU - Zhang HeYing AU - Kozak, C. A. AU - Wilder, R. L. JO - Genomics (San Diego) JF - Genomics (San Diego) Y1 - 1996/// VL - 37 IS - 3 SP - 386 EP - 389 SN - 0888-7543 AD - Zha HongBin: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19970100575. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Animal Breeding; Agricultural Biotechnology N2 - A rat genomic cosmid library was screened with the mouse epimorphin cDNA probe and a single cosmid clone containing the rat epimorphin gene (Epim) was isolated. Nine contiguous exons were identified in rat Epim. The deduced amino acid sequence of rat Epim shared 96 and 86% identity with mouse and human epimorphins respectively. Using somatic cell hybridization, rat Epim was assigned to chromosome 12 and the gene was regionally localized to 12q16 by fluorescence in situ hybridization. The location of mouse Epim was determined by linkage analysis in 2 crosses: (NFS/N or C58/J ×Mus spretus) ×M. musculus musculus; (NFS/N ×Mus spretus) ×Mus spretus or C58/J. Epim was localized to chromosome 5, closely linked to Gus and Gnb2. The rat genomic DNA sequences have been submitted to GenBank/EMBL with accession numbers U35039-U35047. KW - biotechnology KW - DNA hybridization KW - gene mapping KW - linkage KW - maps KW - nucleotide sequences KW - somatic hybridization KW - man KW - mice KW - rats KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - DNA sequences KW - epimorphin KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Laboratory Animal Science (LL040) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970100575&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency: LPL(Asp9 -> Asn, Tyr262 -> His). AU - Rouis, M. AU - Lohse, P. AU - Dugi, K. A. AU - Lohse, P. AU - Beg, O. U. AU - Ronan, R. AU - Talley, G. D. AU - Brunzell, J. D. AU - Santamarina-Fojo, S. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1996/// VL - 37 IS - 3 SP - 651 EP - 661 SN - 0022-2275 AD - Rouis, M.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961404164. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9004-02-8. Subject Subsets: Human Nutrition KW - deficiency KW - glycosaminoglycans KW - homozygosity KW - hypertriglyceridaemia KW - lipoprotein lipase KW - mutations KW - pancreatitis KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - diacylglycerol lipase KW - hypertriglyceridemia KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Synthesis and assembly of chimeric human immunodeficiency virus gag pseudovirions. AU - Tobin, G. J. AU - Nagashima, K. AU - Gonda, M. A. JO - Intervirology JF - Intervirology Y1 - 1996/// VL - 39 IS - 1/2 SP - 40 EP - 48 SN - 0300-5526 AD - Tobin, G. J.: Laboratory of Cell and Molecular Structure, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Md., USA. N1 - Accession Number: 19972007872. Publication Type: Journal Article. Language: English. Number of References: 43 ref. N2 - Expression of the HIV Gag precursor in insect cells by recombinant baculoviruses results in the assembly and budding of noninfectious pseudovirions that resemble immature virus. Three strategies for packaging additional viral epitopes into pseudovirions were examined: coinfection of insect cells with individual baculoviruses encoding separate Gag and Env structural genes, inframe Gag-Env fusion proteins, and Gag-frameshift-Env fusion proteins. Electron microscopy and Western blot analysis indicated that neither the coinfection nor the inframe fusion strategies reliably produced large quantities of structurally stable chimeric pseudovirions. The frameshift fusion method utilized the retroviral Gag-Pol ribosomal frameshift mechanism for the coexpression of Gag and Gag-frameshift-Env fusion proteins. Large quantities of pseudovirions containing both the Gag and Env epitopes were produced in insect cells. Mice inoculated with the Gag-frameshift-Env pseudovirions developed cytotoxic lymphocyte responses to both HIV Gag and Env epitopes. Vaccine and immunotherapeutic applications of chimeric pseudovirions are discussed. KW - acquired immune deficiency syndrome KW - cytotoxicity KW - epitopes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphocyte transformation KW - lymphocytes KW - mixed infections KW - precursors KW - responses KW - ribosomes KW - vaccines KW - western blotting KW - Baculoviridae KW - man KW - mice KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - AIDS KW - antigenic determinants KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - multiple infections KW - recombinant viruses KW - strategies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007872&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of cytokines on antiviral pharmacokinetics: an alternative approach to assessment of drug interactions using bioequivalence guidelines. AU - Piscitelli, S. C. AU - Amantea, M. A. AU - Vogel, S. AU - Bechtel, C. AU - Metcalf, J. A. AU - Kovacs, J. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1996/// VL - 40 IS - 1 SP - 161 EP - 165 SN - 0066-4804 AD - Piscitelli, S. C.: Department of Pharmacy, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19962004735. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 69655-05-6, 30516-87-1. KW - analogues KW - antiviral agents KW - cytokines KW - didanosine KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - immunomodulators KW - nucleoside analogues KW - nucleosides KW - pharmacokinetics KW - zidovudine KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - analogs KW - AZT KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004735&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells. AU - Das, R. AU - Vonderhaar, B. K. JO - Breast Cancer Research and Treatment JF - Breast Cancer Research and Treatment Y1 - 1996/// VL - 40 IS - 2 SP - 141 EP - 149 SN - 0167-6806 AD - Das, R.: Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892-1402, USA. N1 - Accession Number: 19960404078. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9002-62-4, 60-18-4. Subject Subsets: Dairy Science N2 - It was demonstrated that 2 prolactin (PRL)-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells respond to treatment with up to 250 ng/ml PRL for up to 15 min by rapid and transient activation of a series of kinases. Raf-1 was activated within 2-5 min of PRL treatment. This was followed rapidly by activation of MEK (mitogen activated protein, MAP kinase kinase) and MAP kinase activity in these cells. Increased MAP kinase activity was accompanied by tyrosine phosphorylation of both the 42- and 44-kDa isoforms. The tyrosine kinase inhibitors genestein and tyrphostin blocked the increase in MAP kinase activity as well as PRL-induced growth of the T47D cells. It was concluded that the PRL receptor, after binding to PRL in mammary cells, activated the raf-MEK-MAP kinase pathway for signal transduction leading to mitogenesis. KW - activity KW - cell lines KW - enzymes KW - epithelium KW - hormone receptors KW - kinases KW - mammary gland neoplasms KW - mammary glands KW - phosphorylation KW - prolactin KW - tyrosine KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - lactogenic hormone KW - mammary tumour KW - mammotropin KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960404078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Randomized, controlled phase I/II trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients. AU - Davey, R. T., Jr. AU - Chaitt, D. G. AU - Reed, G. F. AU - Freimuth, W. W. AU - Herpin, B. R. AU - Metcalf, J. A. AU - Eastman, P. S. AU - Falloon, J. AU - Kovacs, J. A. AU - Polis, M. A. AU - Walker, R. E. AU - Masur, H. AU - Boyle, J. AU - Coleman, S. AU - Cox, S. R. AU - Wathen, L. AU - Daenzer, C. L. AU - Lane, H. C. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1996/// VL - 40 IS - 7 SP - 1657 EP - 1664 SN - 0066-4804 AD - Davey, R. T., Jr.: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006874. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 30516-87-1, 136817-59-9, 69655-05-6. KW - adverse effects KW - analogues KW - antiviral agents KW - clinical trials KW - combination therapy KW - delavirdine KW - didanosine KW - drug therapy KW - hiv infections KW - human diseases KW - nucleoside analogues KW - nucleosides KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - analogs KW - AZT KW - chemotherapy KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - multimodal treatment KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006874&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Potent activity of 2′-β-fluoro-2′,3′-dideoxyadenosine against human immunodeficiency virus type 1 infection in hu-PBL-SCID mice. AU - Ruxrungtham, K. AU - Boone, E. AU - Ford, H., Jr. AU - Driscoll, J. S. AU - Davey, R. T., Jr. AU - Lane, H. C. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1996/// VL - 40 IS - 10 SP - 2369 EP - 2374 SN - 0066-4804 AD - Ruxrungtham, K.: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20892-1894, USA. N1 - Accession Number: 19972000704. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 4097-22-7, 30516-87-1. N2 - A new antiviral agent, 2′-β-fluoro-2′,3′-dideoxyadenosine (FddA) was evaluated in vivo for anti-HIV activity when administered prior to infection of severe combined immunodeficiency (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID). Following a challenge with 50 × 100% tissue culture infective doses of HIV-1 lymphadenopathy-associated virus, 39 of 42 (93%) control mice developed HIV infection, as shown by positive coculture or positive PCR. Administration of zidovudine decreased the infection rate to 5 of 16 (31%), while administration of FddA decreased the infection rate to 0 of 44. In follow-up controlled studies, the anti-HIV activity of FddA was confirmed, with 18 of 20 control mice showing evidence of HIV infection, compared with 4 of 20 FddA-treated mice. In addition to having direct anti-HIV effects, FddA had a protective effect on human CD4+ T cells in HIV infection. Mice treated with FddA had a significantly higher percentage of CD4+ T cells than controls (10.3%±3.4% vs. 0.27%±0.21%; P=0.01). It is concluded that FddA, with its potent anti-HIV activity in vivo, high oral bioavailability, long intracellular half-life and ability to preserve CD4+ cells in the presence of HIV, appears to be a promising agent for clinical investigation. KW - antiviral agents KW - antiviral properties KW - dideoxyadenosine KW - drug therapy KW - enzyme inhibitors KW - experimental infections KW - HIV-1 infections KW - human immunodeficiency viruses KW - reverse transcriptase inhibitors KW - treatment KW - zidovudine KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anti-viral properties KW - AZT KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000704&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection. AU - Vasudevachari, M. B. AU - Zhang, Y. M. AU - Imamichi, H. AU - Imamichi, T. AU - Falloon, J. AU - Salzman, N. P. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1996/// VL - 40 IS - 11 SP - 2535 EP - 2541 SN - 0066-4804 AD - Vasudevachari, M. B.: Laboratory of Molecular Retrovirology, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972000064. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 150378-17-9. N2 - A rapid procedure for the detection of drug-resistant variants in patients on protease inhibitor therapy, based on the loss of 2 HindII restriction enzyme digestion sites, was used to detect the emergence of mutated viruses at various times after the initiation of therapy with the HIV-1 protease inhibitor indinavir. The method included viral RNA isolation from plasma and reverse transcription polymerase chain reaction (PCR) amplification of the protease gene with fluorescence-tagged primers. The PCR product was digested with HindII, the cleavage products were separated on a urea-acrylamide gel in a DNA sequencer and the extent of cleavage was automatically analysed with commercially available software. In viruses from 34 blood samples from 4 patients, mutations leading to an amino acid change at residue 82 appeared as early as 6 weeks after the start of therapy and persisted throughout the course of the study period (48 weeks). Mutations leading to double substitutions at residues 82 and 90 were seen at a lower frequency and appeared later than the change at position 82. The changes detected by restriction enzyme cleavage were confirmed by DNA sequencing of the cloned protease genes by reverse transcription PCR amplification of viral RNA from isolates in plasma. In addition to the changes at positions 82 and 90 M46L/I, G48V, and I54V substitutions were identified in isolates derived from indinavir-treated patients. HindII analysis of uncloned, PCR-amplified DNA could be a useful rapid screening procedure for the detection of virus isolates containing mutations at amino acid residues 82 and 90 in the HIV-1 protease gene. KW - analytical methods KW - detection KW - drug resistance KW - drug therapy KW - genes KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - indinavir KW - mutations KW - nucleotides KW - polymerase chain reaction KW - proteinase inhibitors KW - proteinases KW - screening KW - techniques KW - treatment KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - PCR KW - protease inhibitors KW - proteases KW - screening tests KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000064&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A benzoic acid glycoside from Geniostoma antherotrichum. AU - Rashid, M. A. AU - Gustafson, K. R. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Phytochemistry JF - Phytochemistry Y1 - 1996/// VL - 41 IS - 4 SP - 1205 EP - 1207 SN - 0031-9422 AD - Rashid, M. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, National Cancer Institute, Bldg 1052, Rm. 121, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19960303134. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 65-85-0. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - A glycoside derivative was isolated from an HIV [human immunodeficiency virus]-inhibitory extract of G. antherotrichum (collected from Papua New Guinea). Its structure was characterized as 2-hydroxy-3-O-β-D-glucopyranosyl-benzoic acid from spectral data. This compound was inactive in the National Cancer Institute's primary anti-HIV screen. The HIV-inhibitory activity of the extract was due to polymeric tannins. KW - antiviral plants KW - antiviral properties KW - benzoic acid KW - chemical structure KW - glycosides KW - human immunodeficiency viruses KW - medicinal plants KW - medicinal properties KW - phenolic compounds KW - plant composition KW - plant extracts KW - tannins KW - Papua New Guinea KW - Loganiaceae KW - plants KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - ACP Countries KW - APEC countries KW - Commonwealth of Nations KW - Developing Countries KW - New Guinea KW - Melanesia KW - Australasia KW - Oceania KW - Pacific Islands KW - anti-viral properties KW - chemical constituents of plants KW - drug plants KW - Geniostoma KW - Geniostoma antherotrichum KW - heterosides KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - tannic acid KW - Plant Composition (FF040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960303134&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A 2 week pair-fed study of early X-irradiation effects on rat major salivary gland function. AU - Nagler, R. M. AU - Baum, B. J. AU - Fox, P. C. JO - Archives of Oral Biology JF - Archives of Oral Biology Y1 - 1996/// VL - 41 IS - 7 SP - 713 EP - 717 SN - 0003-9969 AD - Nagler, R. M.: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-1190, USA. N1 - Accession Number: 19971409190. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - Parotid and submandibular salivary output and body weight were measured in male Wistar rats at 4, 8, 11 and 14 days after 15 Gy X-irradiation of the head and neck. Comparisons were made with 2 groups: a non-irradiated group with food and water intake restricted to that of the irradiated group (pair-fed) and a non-irradiated, ad libitum-fed control group. Parotid saliva output was significantly decreased in the irradiated group at 4, 8 and 11 days compared with the control group. The pair-fed rats also had significantly decreased parotid output at these time points and their parotid function did not differ from that of the irradiated rats. At 14 days, all 3 groups demonstrated similar parotid function. Submandibular salivary output was not affected to the same extent. Only at a single time point (11 days) was flow significantly decreased in the irradiated group. Total body weight was less than that of control rats for the irradiated and pair-fed rats at all time points. It is suggested that the early effects of radiation on salivary glands are due, in part, to limited intake of food and water during the immediate post-irradiation period. KW - body weight KW - food intake KW - irradiation KW - mandibular glands KW - parotid gland KW - radiation KW - saliva KW - salivary glands KW - water intake KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - function KW - salivary secretions KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409190&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Breakthrough fungemia due to Hansenula anomala in a leukemic patient successfully treated with amphotericin B. AU - Kunová, A. AU - Špánik, S. AU - Kollár, T. AU - Trupl, J. AU - Krčméry, V., Jr. T2 - Chemotherapy (Basel) JO - Chemotherapy (Basel) JF - Chemotherapy (Basel) Y1 - 1996/// VL - 42 IS - 2 SP - 157 EP - 158 SN - 0009-3157 AD - Kunová, A.: Department of Hematology and Microbiology, National Cancer Institute, University of Trnava, Bratislavia, Slovakia. N1 - Accession Number: 19961202019. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Registry Number: 1397-89-3, 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 46-yr-old woman from Slovakia who developed fever during chemotherapy for acute myelogenous leukaemia and while receiving prophylactic antibiotics and fluconazole. Blood cultures grew H. anomala and intravenous amphotericin B (1 mg/kg daily) was started. Blood cultures continued to be positive for H. anomala for 5 d, after which a central venous catheter was removed. Symptoms resolved after 25 d of amphotericin B therapy (total dose of 1725 g). KW - amphotericin B KW - antifungal agents KW - blood KW - case reports KW - drug therapy KW - fluconazole KW - fungaemia KW - hosts KW - human diseases KW - immunocompromised hosts KW - infections KW - leukaemia KW - mycoses KW - opportunistic infections KW - predisposition KW - therapy KW - women KW - Slovakia KW - man KW - Pichia anomala KW - Saccharomycetaceae KW - Hansenula KW - Pichiaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Pichia KW - blood cancer KW - chemotherapy KW - fungemia KW - fungistats KW - fungus KW - Hansenula anomala KW - leucaemia KW - leukemia KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lipid requirements and lipid uptake by Giardia lamblia trophozoites in culture. AU - Luján, H. D. AU - Mowatt, M. R. AU - Nash, T. E. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1996/// VL - 43 IS - 3 SP - 237 EP - 242 SN - 1066-5234 AD - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, Maryland 20892-0425, USA. N1 - Accession Number: 19960804841. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 57-88-5. Subject Subsets: Protozoology; Tropical Diseases N2 - To investigate the lipid requirements of Giardia lamblia [G. duodenalis] trophozoites and the mechanisms of lipid uptake, serum-free TYI-S-33 medium was supplemented with lipids incorporated into different lipid carriers. It was found that serum lipoproteins, β-cyclodextrins and bile salts are able to supply cholesterol and phospholipids to Giardia and support the multiplication of the parasite in vitro. Growth rates obtained with different lipoproteins or bile salts and lipid mixtures were similar to that in standard culture medium containing serum. Pulse labelling experiments using fluorescent lipid analogues demonstrated that Giardia can take up lipids from lipoproteins, β-cyclodextrins or bile salt micelles, but with different kinetics, and that bile salts greatly facilitated lipid transfer from lipoproteins and cyclodextrins to the parasite surface. The binding of different radioiodinated lipoprotein classes to the trophozoite surface, inhibition of lipoprotein interiorization at 4°C or by cytochalasin D, and incorporation studies using fluorescent low density lipoproteins suggested that a small component of lipid uptake was probably due to endocytosis of lipoproteins. KW - bile salts KW - binding KW - cholesterol KW - culture media KW - endocytosis KW - lipid absorption KW - lipids KW - lipoproteins KW - nutrient requirements KW - nutrient uptake KW - nutrients KW - parasites KW - phospholipids KW - physiology KW - requirements KW - surfaces KW - trophozoites KW - uptake KW - uptake mechanisms KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - dietary standards KW - food requirements KW - lipins KW - nutritional requirements KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804841&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parasite diversity in an endemic region for avian malaria and identification of a parasite causing penguin mortality. AU - McConkey, G. A. AU - Li Jun AU - Rogers, M. J. AU - Seeley, D. C., Jr. AU - Graczyk, T. K. AU - Cranfield, M. R. AU - McCutchan, T. F. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1996/// VL - 43 IS - 5 SP - 393 EP - 399 SN - 1066-5234 AD - McConkey, G. A.: Growth and Development Section, Laboratory of Parasitic Diseases, Building 4, Room B1-28, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970801135. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Veterinary Science; Protozoology; Medical & Veterinary Entomology; Veterinary Science N2 - The population structure of Plasmodium in vectors and host infections was investigated in an area of intense mortality due to malaria in a captive penguin (Spheniscus demersus) colony, using a polymerase chain reaction method for the identification of Plasmodium species by amplification of ribosomal sequences in DNA or RNA. Three phylogenetically distinct groups of avian Plasmodium were detected in mosquitoes (Culex pipiens and C. restuans) collected at the study site (Baltimore Zoo, Maryland, USA) during a period of high transmission. One of the 3 clades of Plasmodium was found to be prevalent in penguins monitored through the malaria transmission season and was identified on morphological criteria as P. relictum. A complete transmission cycle was defined at the study site as this parasite was directly associated with the death of a penguin. However, phylogenetic comparison of ribosomal sequences to an authenticated reference strain of P. relictum indicated that this was not the parasite causing the penguin mortality and therefore that different Plasmodium species may be morphologically indistinguishable. KW - animal diseases KW - disease transmission KW - disease vectors KW - diversity KW - epidemiology KW - identification KW - malaria KW - molecular genetics KW - morphology KW - parasites KW - polymerase chain reaction KW - protozoal infections KW - ribosomal DNA KW - ribosomal RNA KW - transmission KW - zoo animals KW - Maryland KW - USA KW - birds KW - Culex KW - Culex pipiens KW - Culex restuans KW - Culicidae KW - Diptera KW - Plasmodium KW - Plasmodium relictum KW - protozoa KW - Sphenisciformes KW - Spheniscus KW - Spheniscus demersus KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - Culex KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - birds KW - Spheniscidae KW - Sphenisciformes KW - Spheniscus KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - biochemical genetics KW - mosquitoes KW - PCR KW - penguins KW - protozoal diseases KW - rRNA KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Zoo Animals (LL080) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801135&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cryptococcal infections of the central nervous system: an analysis of predisposing factors, laboratory findings and outcome in patients from South India with special reference to HIV infection. AU - Neelam Khanna AU - Chandramuki, A. AU - Anita Desai AU - Ravi, V. JO - Journal of Medical Microbiology JF - Journal of Medical Microbiology Y1 - 1996/// VL - 45 IS - 5 SP - 376 EP - 379 SN - 0022-2615 AD - Neelam Khanna: Department of Microbiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. N1 - Accession Number: 19971200249. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology; Tropical Diseases N2 - Predisposing factors, laboratory findings and outcome were assessed in 60 patients with cryptococcal infections of the central nervous system seen at the National Institute of Mental Health and Neurosciences Hospital, Bangalore, India, during January 1978-June 1995. Predisposing factors for Cryptococcus neoformans infection were identified in 36 patients; HIV infection was the most common factor (18). Cryptococcal cultures were positive in all patients. India ink staining was positive in 48 patients and cryptococcal antigen was detected in 35 of 36 patients tested. Comparison of clinical and laboratory parameters between HIV-positive and HIV-negative patients showed that cerebrospinal fluid cell response was poorer, culture of cryptococci from non-neural sites was more frequent and mortality was higher in the HIV-positive group. Although not statistically significant, concurrent systemic infections, especially tuberculosis, were more frequent in the HIV-positive group. KW - acquired immune deficiency syndrome KW - central nervous system KW - clinical aspects KW - cryptococcosis KW - diagnosis KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - meningitis KW - mycoses KW - opportunistic infections KW - predisposition KW - prognosis KW - risk factors KW - tuberculosis KW - Asia KW - India KW - Karnataka KW - Cryptococcus neoformans KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - AIDS KW - clinical picture KW - CNS KW - european blastomycosis KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Mysore KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200249&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins. AU - Brown, D. R. AU - Brousseau, M. E. AU - Shamburek, R. D. AU - Talley, G. D. AU - Meyn, S. AU - Demosky, S. J., Jr. AU - Santamarina-Fojo, S. AU - Brewer, H. B., Jr. AU - Hoeg, J. M. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1996/// VL - 45 IS - 12 SP - 1447 EP - 1457 SN - 0026-0495 AD - Brown, D. R.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bldg 10, Room 7N115, 10 Center Dr, MSC 1666, Bethesda, MD 20892-1666, USA. N1 - Accession Number: 19971402253. Publication Type: Journal Article. Language: English. Number of References: 92 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - To elucidate the interactions between LDL and HDL in dyslipoproteinaemia a recombinant adenovirus (hLDLR-rAdV) was used to express human LDL receptors (hLDLRs) in LDL receptor-deficient rabbits. hLDLR-rAdV administration resulted in hepatocyte expression and a reduction of total, intermediate-density lipoprotein (IDL) and LDL cholesterol. In addition, hLDLR-rAdV treatment induced increased very-low-density lipoprotein (VLDL) cholesterol, increased VLDL, IDL and LDL triglycerides, decreased α- and pre-β-migrating apolipoprotein E (apo E) and decreased pre-β-migrating apo A-I at 2-4 days posttreatment and increased total plasma apo A-I and pre-β-migrating apo A-I beginning 8-10 days posttreatment. Virtually all plasma apo A-I was present on α- and pre-β-HDL. Pre-β-HDL particles with size and electrophoretic properties consistent with nascent HDL demonstrated the greatest relative apo A-I enrichment following hLDLR-rAdV treatment. It is concluded that enhanced expression of hepatocyte LDLRs by hLDLR-rAdV treatment markedly altered apo A-I-containing lipoproteins and IDL and LDL. The use of recombinant viruses to express physiologically relevant genes in intact rabbits, analogous to transfection of cells in culture, provides a new strategy for the evaluation of effects of specific gene products on metabolic systems in vivo. KW - apolipoproteins KW - blood KW - cholesterol KW - gene expression KW - genetic vectors KW - high density lipoprotein KW - hyperlipaemia KW - lipoproteins KW - liver KW - liver cells KW - low density lipoprotein KW - messenger rna KW - receptors KW - triacylglycerols KW - very low density lipoprotein KW - adenoviridae KW - rabbits KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cloning vectors KW - hepatocytes KW - hyperlipemia KW - mRNA KW - triglycerides KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402253&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of human recombinant growth hormone and human recombinant insulin-like growth factor-1 in patients with human immunodeficiency virus infection. AU - Hirschfeld, S. JO - Hormone Research JF - Hormone Research Y1 - 1996/// VL - 46 IS - 4-5 SP - 215 EP - 221 SN - 0301-0163 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001176. Publication Type: Journal Article. Language: English. Number of References: 105 ref. Registry Number: 9002-72-6. KW - body parts KW - clinical aspects KW - drug therapy KW - hiv infections KW - hormones KW - human diseases KW - human immunodeficiency viruses KW - nutrition KW - somatotropin KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - clinical picture KW - growth hormone KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001176&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enhancement of TAT-induced transactivation of the HIV-1 LTR by two genomic fragments of HHV-6. AU - GarzinoDemo, A. AU - Chen, M. AU - Lusso, P. AU - Berneman, Z. AU - DiPaolo, J. A. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1996/// VL - 50 IS - 1 SP - 20 EP - 24 SN - 0146-6615 AD - GarzinoDemo, A.: Laboratory of Biology and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972001270. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - The ability of four HHV-6 genomic clones derived from HHV-6 to transactivate the long terminal repeat (LTR) of HIV-1 in two cervical carcinoma cell lines and in a T-lymphoid cell line was tested. Two HHV-6 clones, pZVH-14 and pZVB-70, which were previously shown to increase the expression of human papillomavirus (HPV)-transforming genes, were, per se, weak transactivators of the HIV-1 LTR. However, an increased effect occurred when these clones were combined with the HIV-1 transactivator TAT-1. No such effect was seen with two other HHV-6 clones used as controls. Analysis with HIV-1 LTR deletion mutants indicated that this enhancing effect requires the presence of elements contained in both the enhancer region and the TAT activation region (TAR) of HIV-1. This data may have implications for the potential role of HHV-6 in AIDS and AIDS-related cervical carcinoma. KW - acquired immune deficiency syndrome KW - carcinoma KW - cell lines KW - cervix KW - clones KW - cofactors KW - effects KW - enhancers KW - experiments KW - genomes KW - human herpesviruses KW - human immunodeficiency viruses KW - mutants KW - neoplasms KW - Tat protein KW - transactivation KW - women KW - Herpesviridae KW - Human immunodeficiency virus 1 KW - human papillomaviruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - dsDNA viruses KW - DNA viruses KW - human immunodeficiency viruses KW - Papillomaviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Herpesviridae KW - Papillomavirus KW - AIDS KW - cancers KW - human herpesvirus KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - human papillomavirus KW - long terminal repeat KW - Papovaviridae KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Contribution of dieting to the inverse association between energy intake and body mass index. AU - Ballard-Barbash, R. AU - Graubard, I. AU - Krebs-Smith, S. M. AU - Schatzkin, A. AU - Thompson, F. E. JO - European Journal of Clinical Nutrition JF - European Journal of Clinical Nutrition Y1 - 1996/// VL - 50 IS - 2 SP - 98 EP - 106 SN - 0954-3007 AD - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961401678. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Human Nutrition N2 - A study was conducted to examine the association of energy and percentage energy from fat with body mass index (BMI) and determine if self-reported dieting altered observed associations. Dietary intake data based on dietary recalls from 4 nonconsecutive days over a 1 year period were examined relative to BMI. The relation between energy intake and % energy from fat and BMI was examined by linear regression analysis. The sample included 1854 free-living women aged 19-50 years who participated in the 1985-6 Continuing Surveys of Food Intakes by Individuals conducted by the United States Department of Agriculture. Reported energy intake was inversely associated with BMI (regression coefficient (β) = -0.001 24, standard error (s.e.) = 0.00031). Controlling for low energy dieting alone reduced the inverse energy intake-BMI association by about 20% (β = -0.00100, s.e. = 0.00031), compared to reductions of 16, 13 and 10%, respectively, when health status, age and education were added individually to the energy intake - BMI linear regression. Physical activity, smoking status, % energy from fat and report of low fat dieting did not reduce the energy intake-BMI association. Controlling for nondietary factors related to BMI and potentially influencing energy intake reduced the inverse energy intake-BMI association by about 22% (β = -0.00097, s.e. = 0.00025). Further adjustment for low energy dieting on day 1 reduced the inverse energy intake-BMI association by 40% (β = -0.00074, s.e. = 0.00026), suggesting that intermittent energy restriction was a significant factor in the reduced energy intake reported among overweight women. Percent energy from fat was not associated with BMI (β = 0.049, s.e. = 0.025, P=0.055). Exclusion of 37 women reporting poor health status further attenuated the inverse association between energy intake and BMI (β = -0.00064, s.e. = 0.00026), while it strengthened the previously non-significant positive association between % energy from fat and BMI (β = 0.062; s.e. = 0.024). Intermittent energy restriction appeared to be a significant factor in the reduced energy intake reported among overweight women in this sample. Adequate assessment of energy expenditure is required to correctly interpret the association of energy intake to body weight. KW - behaviour KW - body composition KW - body weight KW - energy exchange KW - energy intake KW - feeding behaviour KW - obesity KW - physical activity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - fatness KW - feeding behavior KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961401678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Is Kaposi's sarcoma caused by new herpesvirus? AU - Haverkos, H. W. T2 - Biomedicine & Pharmacotherapy JO - Biomedicine & Pharmacotherapy JF - Biomedicine & Pharmacotherapy Y1 - 1996/// VL - 50 IS - 6-7 SP - 318 EP - 319 SN - 0753-3322 AD - Haverkos, H. W.: National Institute on Drug Abuse, National Institutes of Health, Rockville, MD 20857, USA. N1 - Accession Number: 19972005807. Publication Type: Correspondence. Language: English. Number of References: 15 ref. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human herpesviruses KW - human immunodeficiency viruses KW - immunocompromised hosts KW - Kaposi's sarcoma KW - opportunistic infections KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - AIDS KW - human herpesvirus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005807&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunopathogenesis of HIV infection. AU - Pantaleo, G. AU - Fauci, A. S. JO - Annual Review of Microbiology JF - Annual Review of Microbiology Y1 - 1996/// VL - 50 SP - 825 EP - 854 SN - 0066-4227 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD 20892-1876, USA. N1 - Accession Number: 19972003417. Publication Type: Journal Article. Language: English. Number of References: 103 ref. N2 - The rate of progression of HIV disease may be substantially different among HIV-infected individuals. Following infection of the host with any virus, the delicate balance between virus replication and the immune response to the virus determines both the outcome of the infection, i.e. the persistence versus elimination of the virus, and the different rates of progression. During primary HIV infection, a burst of viraemia occurs that disseminates virus to the lymphoid organs. A potent immune response ensues that substantially, but usually not completely, curtails virus replication. This inability of the immune system to eliminate the virus completely leads to establishment of chronic, persistent infection that over time leads to profound immunosuppression. The potential mechanisms of virus escape from an otherwise effective immune response have been investigated. Clonal deletion of HIV-specific cytotoxic T-cell clones and sequestration of virus-specific cytotoxic cells away from the major site of virus replication represent important mechanisms of virus escape from the immune response that favour persistence of HIV. Qualitative differences in the primary immune response to HIV (i.e. mobilization of a restricted versus broader T-cell receptor repertoire) are associated with different rates of disease progression. Therefore, the initial interaction between the virus and immune system of the host is critical for the subsequent clinical outcome. KW - clones KW - cytotoxicity KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - immunopathology KW - infection KW - interactions KW - pathogenesis KW - persistence KW - receptors KW - replication KW - responses KW - reviews KW - survival KW - T lymphocytes KW - viraemia KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - follicular dendritic cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - non-progressors KW - T cells KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003417&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one. AU - Tisdale, J. F. AU - Figg, W. D. AU - Reed, E. AU - McCall, N. A. AU - Alkins, B. R. AU - Horne, M. K., III JO - American Journal of Hematology JF - American Journal of Hematology Y1 - 1996/// VL - 51 IS - 2 SP - 152 EP - 157 SN - 0361-8609 AD - Tisdale, J. F.: Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD20892, USA. N1 - Accession Number: 19970800534. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 37270-89-6, 9005-49-6, 9041-08-1, 9050-30-0, 308067-58-5, 145-63-1. Subject Subsets: Protozoology N2 - The efficacy of the trypanocide suramin against AIDS and various malignancies has been tested. Thrombocytopenia was observed in early trials with suramin in AIDS but has been uncommon in patients treated for solid tumours. It is now reported that 5 of 67 (7%) patients developed severe thrombocytopenia while receiving suramin as part of a phase II clinical trial for metastatic prostate carcinoma refractory to hormonal therapy. IgG purified from the plasma of one patient caused suramin-dependent platelet aggregation. There was also evidence of cross reactivity between suramin and heparin in this system. An immune mechanism was not observed in the other cases, suggesting that multiple mechanisms may be responsible for severe thrombocytopenia in this patient population. KW - antiprotozoal agents KW - cross reaction KW - heparin KW - IgG KW - immune response KW - neoplasms KW - parasites KW - platelets KW - suramin KW - thrombocytopenia KW - toxicity KW - trypanocides KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - blood platelets KW - cancers KW - heparin sulfate KW - heparin sulphate KW - immunity reactions KW - immunological reactions KW - thrombocytes KW - trypanocidal drugs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv20019, secreted from Saccharomyces cerevisiae. AU - Kaslow, D. C. AU - Sanjai Kumar JO - Immunology Letters JF - Immunology Letters Y1 - 1996/// VL - 51 IS - 3 SP - 187 EP - 189 SN - 0165-2478 AD - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970804491. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology N2 - In an effort to develop a protective vaccine the 19-kDa carboxy-terminus of a major merozoite protein of Plasmodium vivax (yPv20019) was expressed as a His6-tagged, secreted polypeptide in Saccharomyces cerevisiae. Seven H-2 congenic mice strains were each given 3 ip injections of 50 µg purified yPv20019 emulsified in either Freund's complete or incomplete adjuvant on days 0, 21 and 31. Serum samples taken from the mice on days 0, 21, 31 and 41 revealed that 5 of the seven H-2 mouse strains elicited antibodies that recognized yeast produced PV20019 by ELISA. Two strains (haplotypes H2b and H2k) remained negative by ELISA after the 3 vaccinations. It is concluded that the vaccine appears to be immunogenic and widely recognized, and to contain one or more helper T cell epitopes that may allow boosting with subsequent natural infections. KW - immune response KW - immunization KW - laboratory animals KW - merozoites KW - parasites KW - recombinant proteins KW - recombinant vaccines KW - surface proteins KW - vaccines KW - mice KW - Plasmodium vivax KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - membrane proteins KW - merozoite surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804491&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice. AU - Martinez, A. AU - Allegra, C. J. AU - Kovacs, J. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1996/// VL - 54 IS - 3 SP - 249 EP - 252 SN - 0002-9637 AD - Martinez, A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, 10 Center Drive MSC 1662, Bethesda, MD 20892-1662, USA. N1 - Accession Number: 19960803190. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 9002-03-3. Subject Subsets: Protozoology N2 - Epiroprim, an inhibitor of dihydrofolate reductase, was evaluated in vitro and in a mouse model of acute infection for activity against Toxoplasma gondii. The 50% inhibitory concentration (IC50) of epiroprim for T. gondii dihydrofolate reductase was 0.9 µM, similar to that of pyrimethamine, but epiroprim was 650-fold more selective than pyrimethamine for T. gondii compared with human dihydrofolate reductase. While intraperitoneally administered epiroprim (300 mg/kg/day for 14 days) alone was ineffective in mice acutely infected with the RH strain of T. gondii, 100% survival was seen when it was combined with orally administered sulfadiazine (375 mg/kg/day), which alone was also ineffective. Increases in survival were seen in combination with doses of sulfadiazine as low as 0.375 mg/kg/day. Orally administered epiroprim combined with dapsone also prolonged survival. It is considered that epiroprim is an active and potentially less toxic alternative to pyrimethamine for the treatment of toxoplasmosis. KW - antiprotozoal agents KW - dihydrofolate reductase KW - drug therapy KW - experimental infections KW - in vitro KW - inhibitors KW - laboratory animals KW - parasites KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - chemotherapy KW - epiroprim KW - tetrahydrofolate dehydrogenase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803190&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantification of Plasmodium falciparum sporozoites by ribosomal RNA detection. AU - Vernick, K. D. AU - Keister, D. B. AU - Toure, A. AU - Toure, Y. T. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1996/// VL - 54 IS - 4 SP - 430 EP - 438 SN - 0002-9637 AD - Vernick, K. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesa, MD 20892-0425, USA. N1 - Accession Number: 19960803447. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9068-38-6. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Sequences specific to the small subunit ribosomal RNA (SSU rRNA) of the sporogonic stages of P. falciparum were used to design a reverse transcriptase-polymerase chain reaction (RT-PCR) assay that can detect 0.1 sporozoites in total RNA purified from potentially infected mosquitoes (Anopheles gambiae, A. freeborni). A synthetic RNA was made that is amplified in the RT-PCR by the same primers as the parasite SSU rRNA and that serves as an internal control and competitive quantitation standard. The assay was calibrated for quantitation of sporozoites by making a standard curve with RNA from purified and counted sporozoites. The assay accurately measured sporozoite number with a linear range of at least 3 orders of magnitude in a single reaction. Some applications and limitations of the assay are discussed. KW - detection KW - disease vectors KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - reverse transcriptase KW - ribosomal RNA KW - sporozoites KW - techniques KW - Anopheles KW - Anopheles freeborni KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Plasmodium falciparum KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - biochemical genetics KW - mosquitoes KW - PCR KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Beta-carotene increases lung cancer incidence in cigarette smokers. AU - Luca, L. M. de AU - Ross, S. A. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1996/// VL - 54 IS - 6 SP - 178 EP - 180 SN - 0029-6643 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37 Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19961408382. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 7235-40-7, 68-26-8. Subject Subsets: Human Nutrition N2 - This article reviews 2 clinical trials (in Finland and USA) where cigarette smokers, at a high risk for lung cancer, were given β-carotene supplements. In both studies this resulted in an increase in lung cancer cases. KW - antioxidants KW - asbestos workers KW - beta-carotene KW - incidence KW - lung cancer KW - lungs KW - neoplasms KW - retinol KW - reviews KW - supplements KW - tobacco smoking KW - vitamins KW - Finland KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - APEC countries KW - North America KW - America KW - axerophthol KW - cancers KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new metabolite of retinol: all-trans-4-oxo-retinol as a receptor activator and differentiation agent. AU - Ross, S. A. AU - Luca, L. M. de JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1996/// VL - 54 IS - 11, Part1 SP - 355 EP - 359 SN - 0029-6643 AD - Ross, S. A.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19971404697. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 302-79-4, 68-26-8. Subject Subsets: Human Nutrition N2 - This brief critical review discusses the binding and transactivation of retinoic acid receptors by a noncarboxylated retinol metabolite, all-trans-4-oxoretinol, a metabolite of retinol synthesized in mouse embryonal carcinoma F9 cells, which may dispel the notion that retinoic acids are the only transactivators of retinoid receptor-dependant pathways. KW - binding KW - cell cultures KW - cell differentiation KW - ligands KW - metabolites KW - receptors KW - retinoic acid KW - retinol KW - reviews KW - transactivation KW - vitamins KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - cytodifferentiation KW - transcriptional activation KW - tretinoin KW - vitamin A KW - vitamin A acid KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404697&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoic acid response elements as positive and negative regulators of the expression of the homeobox b-1 gene. AU - Luca, L. M. de AU - Ross, S. A. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1996/// VL - 54 IS - 2, I SP - 61 EP - 63 SN - 0029-6643 AD - Luca, L. M. de: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19961405145. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition KW - embryogenesis KW - retinoic acid KW - reviews KW - teratogenesis KW - tretinoin KW - vitamin A acid KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961405145&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cellular and molecular biological analyses of nifurtimox resistance in Trypanosoma cruzi. AU - Nozaki, T. AU - Engel, J. C. AU - Dvorak, J. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1996/// VL - 55 IS - 1 SP - 111 EP - 117 SN - 0002-9637 AD - Nozaki, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970800661. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 23256-30-6. Subject Subsets: Protozoology N2 - Nifurtimox resistance was induced in both epimastigotes and tissue culture-derived trypomastigotes of several T. cruzi strains. The magnitude of nifurtimox resistance was strain-dependent. A variety of karyotype changes occurred in the nifurtimox-resistant (NR) strains. Chromosome-specific DNA probes identified karyotype changes common to the NR strains that were moderately resistant to nifurtimox but not the NR strains that were highly resistant to nifurtimox. A marked increase in nifurtimox resistance in one NR strain was accompanied by a 100% increase in nuclear DNA mass and a 50% increase in kinetoplast DNA mass. These data suggest that nifurtimox resistance can be accompanied by a wide spectrum of DNA changes. Both trypanothione reductase and heat-shock proteins may modulate the effects of exposure of T. cruzi to nifurtimox. However, qualitative or quantitative differences were not detected in these genes or their transcripts between the NR strains and the sensitive strains from which they were derived. An understanding of the spectrum of diversity in nifurtimox resistance at the cellular and molecular levels demonstrated in this report is critical in the development of drug therapies against Chagas' disease. KW - drug resistance KW - in vitro KW - nifurtimox KW - parasites KW - resistance KW - protozoa KW - trypanosoma cruzi KW - invertebrates KW - animals KW - eukaryotes KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of altered sympathetic nervous system activity in the pathogenesis of obesity. AU - Ravussin, E. AU - Tataranni, P. A. JO - Proceedings of the Nutrition Society JF - Proceedings of the Nutrition Society Y1 - 1996/// VL - 55 IS - 3 SP - 793 EP - 802 SN - 0029-6651 AD - Ravussin, E.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, RM 541, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19971400892. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 61 ref. Subject Subsets: Human Nutrition N2 - A review is presented of evidence that the sympathetic nervous system (SNS) may be involved in the regulation of body weight. Topics include: methods to assess SNS activity; SNS activity and obesity; SNS activity and energy expenditure; SNS activity and food intake; and SNS activity and weight gain. KW - autonomic nervous system KW - body weight KW - energy metabolism KW - food intake KW - nervous system KW - obesity KW - reviews KW - sympathetic nervous system KW - weight gain KW - man KW - rodents KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - parasympathetic system KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400892&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana. AU - McCormick, J. L. AU - McKee, T. C. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1996/// VL - 59 IS - 5 SP - 469 EP - 471 SN - 0163-3864 AD - McCormick, J. L.: National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19960307072. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry N2 - Two known quinoline alkaloids (buchapine and 3-(3-methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1H)-quinolinone) and 3 new furoquinoline alkaloids (roxiamines A-C) were isolated from the CH2Cl2-MeOH extract of flowers, leaves and twigs of E. roxburghiana (collected from Thailand) following bioactivity-directed fractionation. Buchapine and 3-(3-methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1H)-quinolinone protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 values of 0.94 and 1.64 µM, respectively); roxiamines A-C were inactive against HIV-1. KW - antiviral properties KW - chemical structure KW - flowers KW - human immunodeficiency viruses KW - leaves KW - medicinal plants KW - plant composition KW - quinoline alkaloids KW - stems KW - Thailand KW - Euodia KW - Rutaceae KW - Rutaceae KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Melicope KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - anti-viral properties KW - chemical constituents of plants KW - drug plants KW - Euodia roxburghiana KW - human immunodeficiency virus KW - medicinal herbs KW - Melicope lunu-ankenda KW - officinal plants KW - Rutales KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960307072&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytotoxic falcarinol oxylipins from Dendropanax arboreus. AU - Bernart, M. W. AU - Cardellina, J. H., II AU - Balaschak, M. S. AU - Alexander, M. R. AU - Shoemaker, R. H. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1996/// VL - 59 IS - 8 SP - 748 EP - 753 SN - 0163-3864 AD - Bernart, M. W.: Laboratory of Drug Discovery Research and Development, National Cancer Institute-Frederick Cancer Research & Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19960310830. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Bioassay-guided fractionation of the crude organic extract of leaves of D. arboreus (collected from Puerto Rico) resulted in the isolation of several compounds cytotoxic to a subset of cell lines within the National Cancer Institute's disease-oriented in vitro tumour-screening panel. The major compound responsible for cytotoxicity was falcarinol. Several other known compounds were isolated and found to be cytotoxic, including dehydrofalcarinol, a diynene, falcarindiol and dehydrofalcarindiol. In addition, 2 novel polyacetylenes, dendroarboreols A and B, were isolated and characterized by standard and inverse-detected NMR methods. Compounds were selected from this series for absolute stereochemical determination using the modified Mosher method. Preliminary in vivo evaluations using a LOX melanoma mouse xenograft model were carried out. KW - alkynes KW - animal models KW - cell lines KW - chemical structure KW - cytotoxic compounds KW - cytotoxicity KW - leaves KW - medicinal plants KW - neoplasms KW - plant composition KW - Puerto Rico KW - Araliaceae KW - mice KW - Apiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Araliaceae KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - acetylenes KW - Araliales KW - cancers KW - chemical constituents of plants KW - Dendropanax KW - Dendropanax arboreus KW - drug plants KW - medicinal herbs KW - officinal plants KW - Porto Rico KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310830&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii. AU - McKee, T. C. AU - Fuller, R. W. AU - Covington, C. D. AU - Cardellina, J. H., II AU - Gulakowski, R. J. AU - Krepps, B. L. AU - McMahon, J. B. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1996/// VL - 59 IS - 8 SP - 754 EP - 758 SN - 0163-3864 AD - McKee, T. C.: Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Bldg. 1052, Rm 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19960310831. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - Four new pyranocoumarins were isolated from extracts of C. lanigerum var. austrocoriaceum and C. teysmannii var. inophylloide (collected from Singapore and Malaysia, respectively). The structural elucidation and anti-HIV activity of calanolide E2, cordatolide E, pseudocordatolide C and calanolide F, along with a simple prenylated coumarin precursor, are described. KW - antiviral plants KW - antiviral properties KW - chemical structure KW - coumarins KW - human immunodeficiency viruses KW - medicinal plants KW - plant composition KW - plant extracts KW - Malaysia KW - Singapore KW - Calophyllum KW - Clusiaceae KW - plants KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Calophyllum KW - APEC countries KW - ASEAN Countries KW - Commonwealth of Nations KW - Developing Countries KW - South East Asia KW - Asia KW - Threshold Countries KW - anti-viral properties KW - Calophyllum lanigerum KW - Calophyllum teysmannii KW - chemical constituents of plants KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960310831&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cold acclimation-associated changes in brown adipose tissue do not necessarily indicate an increase of nonshivering thermogenesis in C57BL/6J mice. AU - Talan, M. I. AU - Kirov, S. A. AU - Clow, L. A. AU - Kosheleva, N. A. JO - Physiology & Behavior JF - Physiology & Behavior Y1 - 1996/// VL - 60 IS - 5 SP - 1285 EP - 1289 SN - 0031-9384 AD - Talan, M. I.: Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Russia. N1 - Accession Number: 19971400366. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - Non-shivering thermogenesis was examined in C57BL/67 mice that did not improve their cold tolerance after a cold-acclimation procedure (3-h partial restraint at 6°C, repeated 3-times at 2-week intervals). After cold-acclimation, mice were anaesthetized, paralysed and artificially ventilated. Oxygen consumption and carbon dioxide production were examined and metabolic heat production (MHP) was calculated while body temperature was artificially lowered 7.5°C from control. In a separate group of mice, the total amount and concentration of mitochondrial uncoupling protein, thermogenin (UCP), in interscapular brown adipose tissue (BAT) was examined immediately after completion of the cold-acclimation procedure. The concentration and the content of UCP in the mitochondria of interscapular BAT was significantly higher in all mice that had undergone the cold-acclimation procedure, regardless of its outcome, than in mice that had never been exposed to an environment below room temperature (NAIVE). MHP increased significantly during body cooling in all mice. However, MHP before and during cold-acclimation in mice that did not improve their cold tolerance was significantly lower than that in mice in which cold tolerance was improved and was not different from MHP of the NAIVE mice. Thus, in mice in which cold tolerance did not improve after repeated cold exposure, the anatomical and biochemical changes in BAT typical of cold-acclimation were not associated with a cold-induced increase in MHP. It was concluded that the expression of UCP in BAT is a necessary but not sufficient, attribute of cold-acclimation. Cold-acclimation, measured as increased cold tolerance, occurs only if synthesis of UCP in BAT is associated with an increased cold-induced response of the sympathetic nervous system. KW - acclimatization KW - adipose tissue KW - body temperature KW - brown fat KW - cold KW - cold stress KW - cold tolerance KW - environmental temperature KW - heat production KW - mitochondria KW - regulation KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorigenesis KW - thermogenesis KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400366&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body weight: estimation of risk for breast and endometrial cancers. AU - Ballard-Barbash, R. AU - Swanson, C. A. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1996/// VL - 63 IS - SUP 3 SP - 437S EP - 441S SN - 0002-9165 AD - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 343, 6130 Executive Blvd Msc 7344, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19961402728. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition KW - body weight KW - breast cancer KW - endometrium KW - estimation KW - mammary gland neoplasms KW - neoplasms KW - obesity KW - prognosis KW - risk KW - weight gain KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - endometrial area KW - fatness KW - mammary tumour KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402728&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation of energy, fat, and fiber intakes to plasma concentrations of estrogens and androgens in premenopausal women. AU - Dorgan, J. F. AU - Reichman, M. E. AU - Judd, J. T. AU - Brown, C. AU - Longcope, C. AU - Schatzkin, A. AU - Forman, M. AU - Campbell, W. S. AU - Franz, C. AU - Kahle, L. AU - Taylor, P. R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1996/// VL - 64 IS - 1 SP - 25 EP - 31 SN - 0002-9165 AD - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19961406231. Publication Type: Journal Article. Language: English. Number of References: 72 ref. Subject Subsets: Human Nutrition N2 - Dietary energy, fat and fibre intakes were estimated from 7-day food records completed by 90 premenopausal women on days 14-20 of their menstrual cycles. Fasting blood specimens were collected on days 5-7, 12-15 and 21-23 of each participant's cycle and pooled to create follicular-, midcycle- and luteal-phase samples, respectively, for analysis. Energy intake was associated inversely with plasma androstenedione and dehydroepiandrosterone sulfate (DHEAS), averaged across the 3 menstrual cycle phases, and directly with the probability of a luteal-phase rise in progesterone. For each additional 1 MJ (239 kcal) consumed, androstenedione decreased by 6.0% (95% CI: -8.4, -3.6%), DHEAs decreased by 5.1% (95% CI: -9.6, -0.4%) and the probability of a progesterone rise increased by 60% (95% CI: 5, 145%). After energy intake was adjusted for, the ratio of polyunsaturated to saturated fat (P:S) in the diet was significantly inversely associated with plasma estradiol and estrone during the luteal phase of the menstrual cycle. For each 0.1 increment in the P:S, there was a 7.6% (95% CI: -14.3, -0.5%) decrease in estradiol and a 6.8% (95% CI: -12.7, -0.6%) decrease in estrone. Results support a relation between both energy and fat ingestion and plasma sex hormone concentrations in premenopausal women. KW - androgens KW - blood KW - diet KW - diet studies KW - energy KW - energy intake KW - fats KW - fibre KW - intake KW - oestrogens KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - estrogens KW - fiber KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406231&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The fluctuation of plasma carotenoid concentrations by phase of the menstrual cycle: a controlled diet study. AU - Forman, M. R. AU - Beecher, G. R. AU - Muesing, R. AU - Lanza, E. AU - Olson, B. AU - Campbell, W. S. AU - McAdam, P. AU - Raymond, E. AU - Schulman, J. D. AU - Graubard, B. I. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1996/// VL - 64 IS - 4 SP - 559 EP - 565 SN - 0002-9165 AD - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961410574. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 7488-99-5, 7235-40-7, 57-88-5, 50-28-2, 9002-67-9, 502-65-8, 540-04-5, 27664-65-9, 57-83-0, 68-26-8, 127-40-2, 432-70-2. Subject Subsets: Human Nutrition N2 - Non-smoking, premenopausal women (n=12; aged 27±3 years) with confirmed ovulatory cycles were given a standard diet with total carotenoids 10 mg/day for 2 cycles under isoenergetic conditions. Blood was drawn for simultaneous measurement of carotenoids, lipoproteins and hormones on menses days 1-2, 4-6, 11 through 1 day after the luteinizing hormone surge and 7-8 days after the surge, representing the menses, early and late follicular and midluteal phases, respectively. Regression modeling with adjustment for plasma cholesterol concentrations was used to compare mean individual and total plasma carotenoid concentrations by phase of the cycle. Plasma carotenoid concentrations were at their lowest at menses and significantly higher thereafter, except for α-carotene. Compared with plasma concentrations at menses, β-carotene peaked (increased by 9%, P=0.01) in the late follicular phase. Plasma lutein/zeaxanthin and anhydrolutein concentrations were higher by 8-11% (P≤0.006) and by 15-31% (P≤0.02), respectively, during the last 3 phases. Plasma lycopene and phytofluene concentrations peaked (increased by 12%, P=0.004; and by 21%, P=0.006, respectively) at the midluteal phase. This cyclic fluctuation may affect the estimation of the plasma carotenoid-disease relation in studies of premenopausal women. KW - alpha-carotene KW - beta-carotene KW - blood KW - carotenoids KW - cholesterol KW - estradiol KW - high density lipoprotein KW - lh KW - lipoproteins KW - low density lipoprotein KW - lycopene KW - mammary glands KW - menstrual cycle KW - phytoene KW - phytofluene KW - plasma KW - progesterone KW - retinol KW - vitamins KW - women KW - xanthophyll KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - lutein KW - luteinizing hormone KW - oestradiol KW - tetraterpenoids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Human Reproduction and Development (VV060) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410574&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differences in body composition of black and white girls. AU - Yanovski, J. A. AU - Yanovski, S. Z. AU - Filmer, K. M. AU - Hubbard, V. S. AU - Avila, N. AU - Lewis, B. AU - Reynolds, J. C. AU - Flood, M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1996/// VL - 64 IS - 6 SP - 833 EP - 839 SN - 0002-9165 AD - Yanovski, J. A.: Warren Grant Magnuson Clinical Center, Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19971401432. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition N2 - Twenty black and 20 white normal-weight American girls (7-10 years old) were recruited, who were matched for weight, body mass index (BMI), bone age, chronological age, Tanner breast stage and socioeconomic status. Each underwent anthropometric measurements, bioelectrical impedance analysis, dual-energy X-ray absorptiometry (DXA) and abdominal magnetic resonance imaging (MRI) for estimation of total (TAT), visceral (VAT) and subcutaneous (SAT) adipose tissue. Serum lipids and fasting and 2-h oral-glucose-tolerance test (OGTT) glucose and insulin concentrations were also estimated. There were no differences between groups in absolute waist circumference or waist-to-hip ratio, but waist-to-thigh ratio was decreased in black compared with white girls. Black girls had increased bone mineral density and decreased TAT, VAT and SAT compared with whites. VAT was not significantly correlated with any measure of insulin, or with serum lipids. However, basal and 2-h OGTT serum insulin were significantly correlated with SAT, estimated by MRI in black girls (r² = 0.46 for basal insulin, P=0.001; r² = 0.31 for 2-h insulin, P=0.01) but not in white girls. It was concluded that there are significant racial differences in body composition and differences in the strength of association between abdominal adipose tissue depots and insulin sensitivity in black and white girls. KW - adipose tissue KW - anthropometric dimensions KW - blacks KW - body composition KW - body fat KW - children KW - ethnic groups KW - ethnicity KW - girls KW - subcutaneous fat KW - Maryland KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - anthropometric measurements KW - ethnic differences KW - United States of America KW - Social Structure (UU480) (Discontinued March 2000) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401432&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of dietary fats and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study. AU - Dorgan, J. F. AU - Judd, J. T. AU - Longcope, C. AU - Brown, C. AU - Schatzkin, A. AU - Clevidence, B. A. AU - Campbell, W. S. AU - Nair, P. P. AU - Franz, C. AU - Kahle, L. AU - Taylor, P. R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1996/// VL - 64 IS - 6 SP - 850 EP - 855 SN - 0002-9165 AD - Dorgan, J. F.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 211, 6130 Executive Boulevard, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19971401429. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - The effects of fat and fibre consumption on plasma and urine sex hormone concentrations was examined in 43 healthy men (19-56 years old). Men were initially randomly assigned to a low-fat, high-fibre or a high-fat, low-fibre diet for 10 weeks and after a 2-week washout period crossed over to the other diet. Energy content of diets was varied to maintain constant body weight, but averaged ~13.3 MJ/day on both diets. The low-fat diet provided 18.8% of energy from fat with a ratio of polyunsaturated to saturated fat (P:S) of 1.3, whereas the high-fat diet provided 41.0% of energy from fat with a P:S of 0.6. Total dietary fibre consumption from the low- and high-fat diets averaged 4.6 and 2.0 g/MJ daily, respectively. Mean plasma concentrations of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were increased by 13 and 15%, respectively, on the high-fat, low-fibre diet and the difference from the low-fat, high-fibre diet was significant for the SHBG-bound fraction. Men's daily urinary excretion of testosterone also was increased by 13% with the high-fat, low-fibre diet compared with the low-fat, high-fibre diet (P=0.01). Conversely, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were decreased by 12-28% with the high-fat, low-fibre diet (P≤0.01). Results suggest that diet may alter endogenous sex hormone metabolism in men. KW - androgens KW - binding proteins KW - blood KW - diet KW - fats KW - fibre KW - hormones KW - intake KW - men KW - metabolism KW - neoplasms KW - oestrogens KW - polyunsaturated fats KW - prostate KW - saturated fats KW - sex hormones KW - urine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - carrier proteins KW - estrogens KW - fiber KW - polyenoic fats KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401429&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence. AU - Chang, Y. C. AU - Penoyer, L. A. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 6 SP - 1977 EP - 1983 SN - 0019-9567 AD - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19961201402. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The isolation and characterization of the gene, CAP64, which is required for capsule formation in C. neoformans, is described. An encapsulated strain created by complementation of the cap64 mutation produced fatal infection in mice within 25 d, while the cap64 acapsular strain was avirulent. Gene deletion of CAP64 from a wild-type strain resulted in the loss of capsule as well as virulence. Contour-clamped homogeneous electric field gel analysis indicated that CAP64 is located on chromosome III, which is different from the localization of another capsule-related gene, CAP59. The non-linkage between CAP64 and CAP59 was also supported by classical recombinational analysis. Database searches did not reveal any sequence with high similarity to CAP64. The CAP64 locus is contiguous to a convergently transcribed gene which has significant similarity to the gene encoding the yeast proteasome subunit, PRE1. The distance between the cDNA ends of these 2 genes is only 22 bp. It is concluded that these results confirm previous molecular genetic evidence that capsule is an essential factor for the virulence of C. neoformans in the murine model of cryptococcosis. KW - cryptococcosis KW - experimental infections KW - genes KW - genetics KW - infections KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - capsule KW - european blastomycosis KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii. AU - Grunvald, E. AU - Chiaramonte, M. AU - Hieny, S. AU - Wysocka, M. AU - Trinchieri, G. AU - Vogel, S. N. AU - Gazzinelli, R. T. AU - Sher, A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 6 SP - 2010 EP - 2018 SN - 0019-9567 AD - Grunvald, E.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19960804750. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 130068-27-8, 308079-78-9. Subject Subsets: Protozoology N2 - It was shown that a soluble Toxoplasma gondii tachyzoite extract (soluble tachyzoite antigen) can trigger the expression of 4 monokines (IL-12, TNF-α, IL-1β, IL-10) by murine inflammatory macrophages. Further characterization revealed that the parasite molecules in soluble tachyzoite antigen responsible for monokine induction are heat stable at 100°C but differ in sensitivity to protease digestion. Thus, the tachyzoite factors that stimulate TNF-α and IL-1β expression were found to be more resistant to treatment with proteinase K than those responsible for IL-12 and IL-10 induction. Similarly, while the factors responsible for the induction of all 4 monokines were found to be sensitive to periodate oxidation, the TNF-α-stimulating activity was partially resistant to treatment with the compound at a low concentration (1 mM). A further dichotomy in monokine induction signals was inferred from experiments with isoquinoline sulfonamide protein kinase inhibitors. This suggested that the pathways for TNF-α and IL-1β are protein kinase C dependent, whereas expression of IL-12 and expression of IL-10 share distinct signal transduction mechanisms involving other kinases. It is suggested that monokine induction by T. gondii is mediated by glycoproteins that may belong to distinct groups in terms of their biochemical properties and intracellular signalling pathways. KW - antigens KW - cytokines KW - immune response KW - interleukin 1 KW - interleukin 10 KW - interleukin 12 KW - macrophages KW - parasites KW - tachyzoites KW - tumour necrosis factor KW - protozoa KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - antigenicity KW - cachectin KW - cachexin KW - immunity reactions KW - immunogens KW - immunological reactions KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804750&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Specific induction of fibronectin binding activity by hemoglobin in Candida albicans grown in defined media. AU - Yan, S. AU - Nègre, E. AU - Cashel, J. A. AU - Guo, N. AU - Lyman, C. A. AU - Walsh, T. J. AU - Roberts, D. D. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 8 SP - 2930 EP - 2935 SN - 0019-9567 AD - Yan, S.: Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19961201751. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Haemoglobin was shown to be a potent and specific inducer of fibronectin (FN) receptor expression and a defined medium supplemented with haemoglobin that greatly and stably enhances the binding activity of C. albicans for soluble FN is described. Enhancement of FN binding by haemoglobin in strain 44807 was concn-dependent and was maximal at 0.1% haemoglobin with 20- to 80-fold enhancement. The haemoglobin-induced FN binding to C. albicans was saturable, with a Kd of 2.7 × 10-8M. Enhancement required growth of C. albicans in haemoglobin-containing medium, since simply exposing blastoconidia to haemoglobin in a non-growing status did not enhance binding. Induction was reversible following removal of haemoglobin from the growth medium and not associated with germination. Inorganic or protein-bound iron was not sufficient for the induction, since other iron-containing proteins or inorganic iron salts were inactive. Growth in the simple medium yeast nitrogen base supplemented with haemoglobin increased cell adhesion to immobilized FN and to cultured monolayers of bovine corneal endothelial cells. It is suggested that haemoglobin may be an important regulator of FN binding activity in C. albicans and therefore may play a role in its pathogenesis. KW - adhesion KW - culture media KW - endothelium KW - fibronectins KW - haemoglobin KW - matrix proteins KW - pathogenesis KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - hemoglobin KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201751&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. AU - Nagineni, C. N. AU - Pardhasaradhi, K. AU - Martins, M. C. AU - Detrick, B. AU - Hooks, J. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 10 SP - 4188 EP - 4196 SN - 0019-9567 AD - Nagineni, C. N.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 6N 228, Bethesda, Maryland 20892-1596, USA. N1 - Accession Number: 19960806078. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 10102-43-9, 73-22-3, 308079-78-9, 9008-11-1. Subject Subsets: Protozoology N2 - A human retinal pigment epithelial (HRPE) cell in vitro model system was developed to evaluate Toxoplasma gondii replication in ocular toxoplasmosis and the regulation of this replication by cytokines. Replication was quantified by counting the foci of infection (plaque formation) and the numbers of tachyzoites released into the supernatant fluids. Pretreatment of cultures with recombinant human tumour necrosis factor (TNF)-α, interferon (IFN)-α, IFN-β or IFN-γ for 24 h prior to inoculation inhibited T. gondii replication in a dose-dependent manner. Of these cytokines, IFN-γ was the most potent and T. gondii replication was completely inhibited at a concentration of 100 U/ml. The anti-toxoplasmic activity of IFN-γ was significantly blocked by monoclonal antibody to IFN-γ. Treatment of the cultures with IFN-γ from day 1 or 2 pi with T. gondii also offered protection against the parasite. The anti-toxoplasmic activity of TNF-α or IFN-α, -β or -γ in these cultures was independent of the nitric oxide (NO) pathway, since NO production was not found in HRPE cells treated with these cytokines. Addition of tryptophan to IFN-γ-treated cells significantly reversed the inhibitory effects of IFN-γ, suggesting that IFN-γ acts by depleting cellular tryptophan. This effect was confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction of indoleamine 2,3-dioxygenase (IDO), an enzyme that converts tryptophan to kynurenine. The results indicated that interferons inhibit T. gondii replication in HRPE by NO-independent but IDO-dependent mechanisms. KW - cell cultures KW - cells KW - cytokines KW - epithelium KW - eye diseases KW - eyes KW - growth inhibitors KW - human diseases KW - immune response KW - in vitro KW - interferon KW - nitric oxide KW - parasites KW - recombinant proteins KW - retina KW - tachyzoites KW - toxoplasmosis KW - tryptophan KW - tumour necrosis factor KW - protozoa KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cachectin KW - cachexin KW - immunity reactions KW - immunological reactions KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960806078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness. AU - Elson, L. H. AU - Days, A. AU - Calvopiña, M. AU - Paredes, W. AU - Araujo, E. AU - Guderian, R. H. AU - Bradley, J. E. AU - Nutman, T. B. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 12 SP - 5061 EP - 5065 SN - 0019-9567 AD - Elson, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19970802375. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 37341-29-0, 308067-58-5. Subject Subsets: Helminthology; Tropical Diseases N2 - Afro-Ecuadorean individuals from an area in northwest Ecuador where Onchocerca volvulus is hyperendemic (73.9% prevalence) were monitored for infection over the past 16 years. To determine whether in utero exposure to O. volvulus biases a child's subsequent immune responses, children aged 9 to 16 years whose mothers' infection status was known were chosen for study. Children of infected mothers (n = 19) had significantly higher levels of skin microfilariae than children of uninfected mothers (n = 13). While serum levels of O. volvulus-specific IgG, IgG subclasses and IgE showed no significant differences between the 2 groups of children, peripheral blood mononuclear cells of children of infected mothers produced higher levels of Th2-type cytokines to several parasite antigens and lower levels of Th1-type cytokines to nonparasite antigens than those of children of uninfected mothers. Therefore, in utero exposure to O. volvulus has a long-term effect on the child's subsequent cellular immune response that may render the child more susceptible to O. volvulus infection postnatally. KW - children KW - cytokines KW - disease prevalence KW - epidemiology KW - helminths KW - human diseases KW - IgE KW - IgG KW - immune response KW - immunity KW - microfilariae KW - mothers KW - onchocerciasis KW - parasites KW - prenatal period KW - skin KW - T lymphocytes KW - Ecuador KW - South America KW - man KW - Nematoda KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - dermis KW - immunity reactions KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - reagin KW - reaginic antibodies KW - river blindness KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802375&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata. AU - Petter, R. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1996/// VL - 64 IS - 12 SP - 5269 EP - 5273 SN - 0019-9567 AD - Petter, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19971200446. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 7440-44-0, 99-20-7. Subject Subsets: Medical & Veterinary Mycology N2 - The SNF1 gene product, a serine/threonine protein kinase, is a global regulatory protein which has been isolated from several organisms. In Saccharomyces cerevisiae the SNF1 gene product is essential for the derepression of glucose repression since snf1 strains are unable to utilize sucrose, galactose, maltose, melibiose or non-fermentable carbohydrates. Moreover, the SNF1 gene product was suggested to interact with additional regulatory pathways and to affect the expression of multiple target genes as reflected by the pleiotropic nature of the snf1 mutation. The characterization of the SNF1 homologue of C. glabrata [Torulopsis glabrata], a pathogenic yeast phylogenetically related to S. cerevisiae, is reported. The carbon utilization spectrum of C. glabrata is considerably narrower than that of other pathogenic yeasts and the majority of the strains utilize solely glucose and trehalose from among 20 of the most commonly tested carbohydrates. Disruption of the C. glabrata SNF1 homologue resulted in the loss of the ability to utilize trehalose, indicating that even in an organism with such a limited carbon utilization spectrum, the regulatory mechanism governing catabolic repression is preserved. KW - carbon KW - genes KW - genetics KW - physiology KW - trehalose KW - Candida glabrata KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomyces KW - Saccharomycetaceae KW - Torulopsis KW - Pezizomycotina KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200446&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor? AU - Bour, S. AU - Schubert, U. AU - Peden, K. AU - Strebel, K. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 2 SP - 820 EP - 829 SN - 0022-538X AD - Bour, S.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962003976. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - envelope glycoproteins KW - gene expression KW - HIV infections KW - human diseases KW - regulatory genes KW - release KW - viral regulatory proteins KW - Vpu protein KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003976&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-κB binding and protein kinase C activity in primary human astrocytes. AU - Conant, K. AU - Ma, M. AU - Nath, A. AU - Major, E. O. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 3 SP - 1384 EP - 1389 SN - 0022-538X AD - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA. N1 - Accession Number: 19962005270. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Registry Number: 9026-43-1. N2 - Human immunodeficiency virus type 1 (HIV-1) infection has been associated with an increase in the binding of the transcription factor NF-κB to its consensus sequence in the viral promoter. Using cultures of primary human fetal astrocytes, we show that exogenous HIV-1 Tat protein, which has been demonstrated to be released from infected cells, is associated with an increase in the binding of this transcription factor to an HIV-1 long terminal repeat κB sequence. This effect occurs rapidly and is independent of new protein synthesis. We also demonstrate that extracellular Tat protein is associated with an increase in protein kinase C activity. If Tat functions similarly in other cell types, such findings could relate to some of this protein's previously described physiological effects. These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor. KW - binding KW - HIV-1 infections KW - human diseases KW - protein kinase KW - Tat protein KW - transcription factors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Folding, assembly, and intracellular trafficking of the human immunodeficiency virus type 1 envelope glycoprotein analyzed with monoclonal antibodies recognizing maturational intermediates. AU - Otteken, A. AU - Earl, P. L. AU - Moss, B. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 6 SP - 3407 EP - 3415 SN - 0022-538X AD - Otteken, A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0455, USA. N1 - Accession Number: 19962008138. Publication Type: Journal Article. Language: English. Number of References: 48 ref. N2 - Monoclonal antibodies (MAbs) that bind linear or conformational epitopes on monomeric or oligomeric HIV-1 envelope glycoproteins were screened for their recognition of maturational intermediates. On the basis of reactivities with gp160 at different times after pulse-labelling, the MAbs were sorted into groups that exhibited binding which was immediate and constant, immediate but transient, delayed, late, or very late. This grouping was consistent with the selectivity of the MAbs for structural features of gp160. Thus, a MAb to the V3 loop reacted with envelope proteins at all times, in accord with the relative conformational independence and accessibility of the epitope. Several MAbs that preferentially react with monomeric gp160 exhibited diminished binding after the pulse. A 10-min. lag occurred before gp160 reacted with conformational MAbs that inhibited CD4 binding. The availability of epitopes for other conformational MAbs, including some that react equally with monomeric and oligomeric gp160 and some that react better with oligomeric forms, was half-maximal in 30 min. and closely followed the kinetics of gp160 oligomerization. Remarkably, there was a 1- to 2-h delay before gp160 reacted with stringent oligomer-specific MAbs. After 4 h, approximately 20% of the gp160 was recognized by these MAbs. Epitopes recognized by monomer-specific or CD4-blocking MAbs but not by oligomer-dependent MAbs were present on gp160 molecules associated with the molecular chaperone BiP/GRP78. MAbs with a preference for monomers reacted with recombinant or HIV-1 envelope proteins in the endoplasmic reticulum, whereas the oligomer-specific MAbs recognized them in the Golgi complex. Additional information regarding gp160 maturation and intracellular trafficking was obtained by using brefeldin A, dithiothreitol, and a low temperature. KW - conformation KW - envelope glycoproteins KW - envelope protein gp160 KW - epitopes KW - HIV-1 infections KW - human diseases KW - monoclonal antibodies KW - processing KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenic determinants KW - body conformation KW - gp160 KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008138&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. AU - Hirsch, V. M. AU - Fuerst, T. R. AU - Sutter, G. AU - Carroll, M. W. AU - Yang, L. C. AU - Goldstein, S. AU - Piatak, M. Jr. AU - Elkins, W. R. AU - Alvord, W. G. AU - Montefiori, D. C. AU - Moss, B. AU - Lifson, J. D. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 6 SP - 3741 EP - 3752 SN - 0022-538X AD - Hirsch, V. M.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. N1 - Accession Number: 19962008148. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - The dynamics of plasma viremia were explored in a group of 12 SIV-infected rhesus macaques (Macaca mulatta) that had received prior immunization with either nonrecombinant or trivalent (gag-pol, env) SIV-recombinant vaccinia viruses. Three distinct patterns of viral replication observed during and following primary viremia accounted for significant differences in survival times. High-level primary plasma viremia with subsequently increasing viremia was associated with rapid progression to AIDS (n = 2). A high-level primary plasma virus load with a transient decline and subsequent progressive increase in viremia in the post-acute phase of infection was associated with progression to AIDS within a year (n = 6). Low levels of primary plasma viremia followed by sustained restriction of virus replication were associated with maintenance of normal lymphocyte subsets and intact lymphoid architecture (n = 4), reminiscent of the profile observed in human immunodeficiency virus type 1-infected long-term nonprogressors. Three of four macaques that showed this pattern had been immunized with an SIV recombinant derived from the attenuated vaccinia virus, modified vaccinia virus Ankara. These data link the dynamics and extent of virus replication to disease course and suggest that sustained suppression of virus promotes long-term, asymptomatic survival of SIV-infected macaques. These findings also suggest that vaccine modulation of host immunity may have profound beneficial effects on the subsequent disease course, even if sterilizing immunity is not achieved. KW - animal models KW - disease course KW - HIV-1 infections KW - immune response KW - immunization KW - survival KW - viraemia KW - Human immunodeficiency virus 1 KW - Macaca KW - simian immunodeficiency virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. AU - Men RuHe AU - Bray, M. AU - Clark, D. AU - Chanock, R. M. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 6 SP - 3930 EP - 3937 SN - 0022-538X AD - Men RuHe: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19970500141. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3′ noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne flaviviruses have been identified. A series of deletions that range from 30 to 262 nt were introduced into this upstream region of full-length DEN4 cDNA to create viable deletion mutants, some of which might prove to be useful for inclusion in a live attenuated virus vaccine. When studied by an infectious-centre assay, most full-length RNA transcripts of the deletion constructs exhibited reduced infectivity when transfected into simian LLC-MK2 cells compared with the full-length RNA transcripts of wild-type parental virus. Deletion mutations that extended as far as the 5′ boundary of the 3′ noncoding region and whose 3′ boundary did not extend beyond the last 113 nt of the 3′ end were viable. With the exception of mutant 3′d 303-183, which contained a deletion of nt 303 to 183 from the 3′ terminus, deletion mutants produced plaques that appeared late on simian LLC-MK2 cells or exhibited a small-plaque morphology on Aedes albopictus C6/36 cells compared with the wild-type virus. These mutants also replicated less efficiently and attained a lower titre in LLC-MK2 cells than parental wild-type virus. Significantly, mutant 3′d 303-183 grew to a high titre and was least restricted in growth. Mutant 3′d 303-183 and 4 other moderately to severely restricted mutants were selected for evaluation of infectivity and immunogenicity in rhesus monkeys. There was a suggestion that occurrence and duration of viraemia were reduced for some of the deletion mutants compared with the wild-type virus. However, more convincing evidence for attenuation of some of the mutants was provided by an analysis of antibody response to infection. Mutant 3′d 303-183 induced an antibody response equivalent to that stimulated by wild-type virus, whereas other mutants induced low to moderate levels of antibodies, as measured by radio-immunoprecipitation and virus neutralization. The immunogenicity of these 3′ DEN4 deletion mutants in monkeys appeared to correlate with their efficiency of growth in simian LLC-MK2 cells. One or more mutants may prove to be useful for immunization of humans against disease caused by dengue virus. KW - arboviruses KW - cell culture KW - cell lines KW - immune response KW - infection KW - laboratory animals KW - mutants KW - RNA KW - viraemia KW - Aedes albopictus KW - Culicidae KW - dengue 4 virus KW - dengue virus KW - Diptera KW - Macaca mulatta KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - arthropod-borne viruses KW - Asian tiger mosquito KW - immunity reactions KW - immunological reactions KW - mosquitoes KW - ribonucleic acid KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500141&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge. AU - Bray, M. AU - Men RuHe AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 6 SP - 4162 EP - 4166 SN - 0022-538X AD - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19970500140. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - The current strategy for dengue immunization favours the use of a vaccine containing each of the 4 serotypes. The authors previously employed full-length dengue type 4 virus (DEN4) cDNA to construct a viable intertypic dengue virus of type 1 or type 2 antigenic specificity that contained the genes for the capsid-premembrane-envelope (C-pre-M-E) structural proteins of DEN1 or pre-M and E structural proteins of DEN2 substituting for the corresponding DEN4 genes. Chimaeras DEN1/DEN4 and DEN2/DEN4, which express the nonstructural proteins of DEN4 and the C-pre-M-E structural proteins of DEN1 or the pre-M-E structural proteins of DEN2, and therefore the antigenicity of type 1 or type 2, were used to immunize rhesus monkeys. Other monkeys were inoculated with parental DEN1, DEN2 or cDNA-derived DEN4. Three of 4 monkeys immunized with DEN1/DEN4 developed neutralizing antibodies against DEN1 and were protected against subsequent DEN1 challenge. All 4 monkeys immunized with DEN2/DEN4 developed antibodies against DEN2 and were protected against subsequent DEN2 challenge. DEN1- and DEN2-immunized monkeys were protected against homologous virus challenge, but DEN4-immunized animals became viraemic on cross-challenge with DEN1 or DEN2. In a 2nd experiment, 8 monkeys were immunized with equal mixtures of DEN1/DEN4 and DEN2/DEN4. Each of these monkeys developed neutralizing antibodies against both DEN1 and DEN2 and were protected against subsequent challenge with DEN1 or DEN2. Chimaeric dengue viruses could be used to express serotype-specific antigens in a live attenuated tetravalent human vaccine. KW - arboviruses KW - chimaeras KW - genes KW - immunization KW - laboratory animals KW - vaccines KW - viral proteins KW - dengue 1 virus KW - dengue 2 virus KW - dengue 4 virus KW - dengue virus KW - Macaca mulatta KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - chimeras KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500140&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resistance of previously infected chimpanzees to successive challenges with a heterologous intraclade B strain of human immunodeficiency virus type 1. AU - Shibata, R. AU - Siemon, C. AU - Cho, M. W. AU - Arthur, L. O. AU - Nigida, S. M., Jr. AU - Matthews, T. AU - Sawyer, L. A. AU - Schultz, A. AU - Murthy, K. K. AU - Israel, Z. AU - Javadian, A. AU - Frost, P. AU - Kennedy, R. C. AU - Lane, H. C. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 7 SP - 4361 EP - 4369 SN - 0022-538X AD - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19972005478. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9007-49-2, 63231-63-0. N2 - To test whether the protective effects of attenuated simian immunodeficiency virus vaccines in macaques were applicable to the HIV-1-chimpanzee system, two groups of animals, previously infected with HIV-1IIIB or HIV-1SF2, were each challenged with a heterologous clade B virus, HIV-1DH12. Following challenge, the parameters measured included virus isolation (from plasma. peripheral blood mononuclear cells, and lymph node tissue); quantitative DNA PCR using primers capable of distinguishing HIV-1IIIB, HIV-1SF2, and HIV-1DH12 from one another; and serological assays to monitor changes in binding and neutralizing antibodies. In contrast to an HIV-1-naive chimpanzee that rapidly became infected following the inoculation of HIV-1DH12, the two chimpanzees previously infected with HIV-1IIIB resisted repeated and escalating inoculations of HIV-1DH12, as monitored by virus isolation and PCR. The two animals previously infected with HIV-1SF2 became infected with HIV-1DH12, but in contrast to the case with the HIV-1-naive chimpanzee, no cell-free viral RNA was detected in the plasma by the branched DNA procedure and levels of peripheral blood mononuclear cell-associated viral DNA were reduced 35- to 50-fold. KW - DNA KW - HIV-1 infections KW - human diseases KW - immune response KW - immunization KW - neutralizing antibodies KW - RNA KW - vaccines KW - viral load KW - chimpanzees KW - Human immunodeficiency virus 1 KW - Pan KW - Pongidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinct intranuclear locations. AU - Berthold, E. AU - Maldarelli, F. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 7 SP - 4667 EP - 4682 SN - 0022-538X AD - Berthold, E.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972005475. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Registry Number: 63231-63-0. N2 - Two distinct intranuclear locations were identified for alternatively spliced RNA transcripts expressed from the pNL4-3 infectious molecular clone of human immunodeficiency virus (HIV) type 1. Multiply spliced HIV RNA encoding tat was detected within the nucleus in large clusters; immunostaining and colocalization studies using laser-scanning confocal microscopy revealed that these structures contained the non-small nuclear ribonucleoprotein RNA processing factor, SC35. In contrast, unspliced gag RNA was detected in much smaller granules distributed throughout the nucleus, with little or no association with SC35-containing granules. Analyses of nuclear RNA expressed from recombinant plasmids encoding gag (pCMVgag-2) alone or tat (pCMVtat-2) alone revealed distributions corresponding to those obtained with pNL4-3, indicating that expression within the context of the HIV provirus was not required for the distinct RNA locations detected for these transcripts. The presence of unspliced gag RNA in small granules was confirmed in infections of H9 T-lymphocytic cells, indicating that gag localization was not restricted to transient expression systems. The intranuclear distribution of gag RNA was dependent on specific RNA sequences. Deletion of a portion of the gag gene of pCMVgag-2, containing a cis-repressing inhibitory region, resulted in redirection of unspliced gag RNA from small granules into large SC35-containing clusters. The addition of the Rev-responsive element, RRE, to the deleted pCMVgag-2 construct resulted in RNA transcripts which were no longer associated with SC35. An cellular intron, rabbit β-globin-intervening sequence 2 (IVS-2), was also identified which, when introduced into pCMVgag-2, redirected unspliced gag RNA into SC35-containing granules and permitted rev-independent Gag expression. These findings suggest that redirecting intranuclear RNA localization may influence gene expression. KW - cells KW - gag gene KW - HIV-1 infections KW - human diseases KW - localization KW - nuclei KW - RNA KW - transcription KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cell nuclei KW - DNA transcription KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract. AU - Powell, M. D. AU - Levin, J. G. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 8 SP - 5288 EP - 5296 SN - 0022-538X AD - Powell, M. D.: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Building 6B, Room 216, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19962008169. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 9007-49-2. N2 - At the 3′ end of all retroviral genomes there is a short, highly conserved sequence known as the polypurine tract (PPT), which serves as the primer for plus-strand DNA synthesis. The authors have identified the determinants for in vitro priming by the HIV-1 PPT. They show that when the PPT is removed and placed into different nucleotide contexts, new priming sites are produced at the precise 3′ end of the PPT. In addition, they found that a hybrid consisting of a 15- or 20-nucleotide RNA primer annealed to a 35-nucleotide DNA template is competent for initiation of plus-strand synthesis with HIV-1 reverse transcriptase. Thus, no cis-acting elements appear to be required for priming activity. Changes at the 5′ end of the PPT have no effect on primer function, whereas the identity of bases at the 3′ end is crucial. A primer containing only the 6 G residues from the 3′ end of the wild-type PPT sequence and 9 bases of random sequence at the 5′ end functions like a wild-type PPT. A short hybrid having a similar helical structure but a primary sequence different from that of the PPT is cleaved imprecisely, resulting in initiation of synthesis at multiple sites; however, total primer extension is close to the wild-type level. The authors conclude that helical structure as well as the presence of particular bases at the 3′ end of the PPT is essential for PPT function. KW - DNA KW - genomes KW - HIV-1 infections KW - human diseases KW - nucleotide sequences KW - structure KW - synthesis KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - DNA sequences KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008169&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. AU - Alkhatib, G. AU - Broder, C. C. AU - Berger, E. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 8 SP - 5487 EP - 5494 SN - 0022-538X AD - Alkhatib, G.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 236, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972007819. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - Work in this laboratory previously demonstrated that the tropism of different human immunodeficiency type 1 isolates for infection of human CD4+ continuous cell lines (e.g., T-cell lines and HeLa-CD4 transformants) versus primary macrophages is associated with parallel intrinsic fusogenic specificities of the corresponding envelope glycoproteins (Envs). For T-cell line-tropic isolates, it is well established that the target cell must also contain a human-specific fusion cofactor(s) whose identity is unknown. In this study, we tested the hypothesis that the Env fusion specificities underlying T-cell line versus macrophage tropism are determined by distinct cell type-specific fusion cofactors. We applied a recombinant vaccinia virus-based reporter gene assay for Env-CD4-mediated cell fusion; the LAV and Ba-L Envs served as prototypes for T-cell line-tropic and macrophage-tropic isolates, respectively. We examined CD4+ promyeloctic and monocytic cell lines that are infectible by T-cell line-tropic isolates and become susceptible to macrophage-tropic strains only after treatment with differentiating agents. We observed parallel changes in fusion specificity: untreated cells supported fusion by the LAV but not the Ba-L Env, whereas cells treated with differentiating agents acquired fusion competence for Ba-L. These results suggest that in untreated cells, the block to infection by macrophage-tropic isolates is at the level of membrane fusion; furthermore, the differential regulation of fusion permissiveness for the two classes of Envs is consistent with the existence of distinct fusion cofactors. To test this notion directly, we conducted experiments with transient cell hybrids formed between CD4-expressing nonhuman cells (murine NIH 3T3) and different human cell types. Hybrids formed with HeLa cells supported fusion by the LAV Env but not by the Ba-L Env, whereas hybrids formed with primary macrophages showed the opposite specificity; hybrids formed between HeLa cells and macrophages supported fusion by both Envs. These results suggest the existence of cell type-specific fusion cofactors selective for each type of Env, rather than fusion inhibitors for discordant Env-cell combinations. Finally, analyses based on recombinant protein expression and antibody blocking did not support the proposals by others that the CD44 or CD26 antigens are involved directly in the entry of macrophage-tropic isolates. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. AU - Neuveut, C. AU - Jeang KuanTeh JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 8 SP - 5572 EP - 5581 SN - 0022-538X AD - Neuveut, C.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19962008173. Publication Type: Journal Article. Language: English. Number of References: 70 ref. N2 - HIV-1 Tat is essential for virus replication and is a potent trans activator of viral gene expression. Evidence suggests that Tat also influences virus infectivity and cytopathicity. Extensive structure-function studies of Tat in subgenomic settings with point mutagenesis and transient transfection readouts have been performed. These reporter assays have defined certain amino acid residues as being important for trans activation of reporter plasmids. However, they have not directly addressed functions related to virus replication. The authors studied Tat structure-function in the setting of replicating viruses. They characterized mutations that emerged in Tat during HIV-1 infections of T lymphocytes. To ensure that the selection pressure for change was directed toward protein function, they constructed HIV-1s in which the Tat reading frame was freed from constraints exerted by overlapping with the reading frames of vpr, rev, and env. When these recombinant viruses were passaged in T cells, 26 novel nucleotide changes in tat were observed from sequencing of 220 independently isolated clones. Recloning of these changes into a pNL4-3 molecular background allowed for the characterization of residues in Tat important for virus replication. Interestingly, many of the changes that affected replication when they were assayed in transient trans activation of plasmid reporters were found to be relatively neutral. The authors conclude that the structure-function of Tat in virus replication is incompletely reflected by activity measurements based only on subgenomic transient transfections. KW - acquired immune deficiency syndrome KW - genomes KW - HIV-1 infections KW - human diseases KW - mutations KW - replication KW - tat gene KW - Tat protein KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008173&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. AU - Tabernero, C. AU - Zolotukhin, A. S. AU - Valentin, A. AU - Pavlakis, G. N. AU - Felber, B. K. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 9 SP - 5998 EP - 6011 SN - 0022-538X AD - Tabernero, C.: Human Retrovirus Pathogenesis Group, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19962009114. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 63231-63-0. KW - HIV-1 infections KW - human diseases KW - RNA KW - structure KW - transactivation KW - Human immunodeficiency virus 1 KW - simian immunodeficiency virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009114&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. AU - Nunn, M. F. AU - Marsh, J. W. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 9 SP - 6157 EP - 6161 SN - 0022-538X AD - Nunn, M. F.: Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962009119. Publication Type: Journal Article. Language: English. Number of References: 58 ref. N2 - Although HIV Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with a serine-threonine kinase that recognizes histone H4 as a substrate, is serologically related to rat p21-activated kinase (PAK), and is specifically activated by Rac and Cdc42. These characteristics define the Nef-associated kinase as belonging to the PAK family. PAKs initiate kinase cascades in response to environmental stimuli, and their identification as a target of Nef implicates these signalling molecules in HIV pathogenesis and provides a novel target for clinical intervention. KW - HIV-1 infections KW - human diseases KW - kinases KW - Nef protein KW - pathogenesis KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009119&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of Gag precursors and result in the release of noninfectious virus particles. AU - Turpin, J. A. AU - Terpening, S. J. AU - Schaeffer, C. A. AU - Gang Yu AU - Glover, C. J. AU - Felsted, R. L. AU - Sausville, E. A. AU - Rice, W. G. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 9 SP - 6180 EP - 6189 SN - 0022-538X AD - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702, USA. N1 - Accession Number: 19962009130. Publication Type: Journal Article. Language: English. Number of References: 58 ref. KW - antiviral agents KW - Gag protein KW - HIV-1 infections KW - human diseases KW - inhibitors KW - nucleocapsid proteins KW - processing KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - zinc fingers KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009130&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differential glycosylation, virion incorporation, and sensitivity to neutralizing antibodies of human immunodeficiency virus type 1 envelope produced from infected primary T-lymphocyte and macrophage cultures. AU - Willey, R. L. AU - Shibata, R. AU - Freed, E. O. AU - Cho, M. W. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 9 SP - 6431 EP - 6436 SN - 0022-538X AD - Willey, R. L.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962009122. Publication Type: Journal Article. Language: English. Number of References: 53 ref. KW - envelope protein gp120 KW - HIV-1 infections KW - human diseases KW - lymphocytes KW - macrophages KW - neutralization KW - processing KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - gp120 KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009122&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract. AU - Weixing Wu AU - Henderson, L. E. AU - Copeland, T. D. AU - Gorelick, R. J. AU - Bosche, W. J. AU - Rein, A. AU - Levin, J. G. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 10 SP - 7132 EP - 7142 SN - 0022-538X AD - Weixing Wu: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972007842. Publication Type: Journal Article. Language: English. Number of References: 80 ref. N2 - In an earlier study on minus-strand DNA synthesis catalyzed by murine leukemia virus reverse transcriptase, we described a prominent pause site near the polypurine tract (J. Guo, W. Wu, Z. Y. Yuan, K. Post, R. J. Crouch, and J. G. Levin, Biochemistry 34:5018-5029, 1995). We now report that pausing at this site is due to a stem-loop structure in the RNA template, formed by interaction of a number of bases in the polypurine tract, including the six G's, and a 3′ sequence which includes four C's. Addition of human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein to reverse transcriptase reactions reduces pausing by ~8- to 10-fold and stimulates synthesis of full-length DNA. Thus, NC functions as an accessory protein during elongation of minus-strand DNA and increases the efficiency of DNA synthesis, in this case, by apparently destabilizing a region of secondary structure in the template. Since NC is associated with genomic RNA in the viral core and is likely to be part of a viral replication complex, these results suggest that NC may also promote efficient DNA synthesis during virus replication. Mutational analysis indicates that the features of HIV-1 NC which are important for reduction of pausing include the basic amino acids flanking the first zinc finger, the zinc fingers, and the cysteine and aromatic amino acids within the fingers. These findings suggest that reverse transcription might be targeted by drugs which inactivate the zinc fingers of HIV-1 NC. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007842&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 infection of H9 cells induces increased glucose transporter expression. AU - Sorbara, L. R. AU - Maldarelli, F. AU - Chamoun, G. AU - Schilling, B. AU - Chokekijcahi, S. AU - Staudt, L. AU - Mitsuya, H. AU - Simpson, I. A. AU - Zeichner, S. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 10 SP - 7275 EP - 7279 SN - 0022-538X AD - Sorbara, L. R.: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972007847. Publication Type: Journal Article. Language: English. Number of References: 35 ref. N2 - A clone obtained from a differential display screen for cellular genes with altered expression during human immunodeficiency virus (HIV) infection matched the sequence for the human GLUT3 facilitative glucose transporter, a high-velocity-high-affinity facilitative transporter commonly expressed in neurons of the central nervous system. Northern (RNA) analysis showed that GLUT3 expression increased during infection. Flow cytometry showed that GLUT3 protein expression increased specifically in the HIV-infected cells; this increase correlated with increased 2-deoxyglucose transport in the HIV-infected culture. HIV infection therefore leads to increased expression of a glucose transporter normally expressed at high levels in other cell types and a corresponding increase in glucose transport activity. If HIV infection places increased metabolic demands on the host cell, changes in the expression of a cellular gene that plays an important role in cellular metabolism might provide a more favorable environment for viral replication. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007847&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of chimpanzee peripheral blood mononuclear cells by human immunodeficiency virus type 1 requires cooperative interaction between multiple variable regions of gp120. AU - Cho, M. W. AU - Shibata, R. AU - Martin, M. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 10 SP - 7318 EP - 7321 SN - 0022-538X AD - Cho, M. W.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460, USA. N1 - Accession Number: 19972007850. Publication Type: Journal Article. Language: English. Number of References: 16 ref. N2 - We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infectivity of chimpanzee PBMC, chimeric viruses containing the following components were constructed: (i) the entire envelope gene; (ii) gp120 sequences; (iii) gp41 sequences; and (iv) individual or various combinations of the gp120 variable regions of HIV-1DH125 inserted into the backbone of another HIV-1 isolate (HIV-1AD8), which is unable to infect chimpanzee PBMC. Analyses of virus replication kinetics in human and chimpanzee PBMC revealed that gp120 contains determinants which confer infectivity for chimpanzee PBMC and that the capacity to establish such an infection requires the cooperative interaction between multiple variable regions of the HIV-1DH125 gp120. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007850&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. AU - Ott, D. E. AU - Coren, L. V. AU - Kane, B. P. AU - Busch, L. K. AU - Johnson, D. G. AU - Sowder, R. C., II AU - Chertova, E. N. AU - Arthur, L. O. AU - Henderson, L. E. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 11 SP - 7734 EP - 7743 SN - 0022-538X AD - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001697. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 51 ref. N2 - The authors identified three types of cytoskeletal proteins inside HIV-1 virions by analysing subtilisin-digested particles. HIV-1 virions were digested with protease, and the treated particles were isolated by sucrose density centrifugation. This method removes both exterior viral proteins and proteins associated with microvesicles that contaminate virion preparations. Since the proteins inside the virion are protected from digestion by the viral lipid envelope, they can be isolated and analysed after treatment. Experiments presented here demonstrated that this procedure removed more than 95% of the protein associated with microvesicles. Proteins in digested HIV-1MN particles from infected H9 and CEMSS cell lines were analysed by high-pressure liquid chromatography, protein sequencing, and immunoblotting. The data revealed that three types of cytoskeletal proteins are present in virions at different concentrations relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%). Analysis of proteins within virus particles detected proteolytic fragments of α-smooth muscle actin and moesin that were cleaved at sites which might be recognized by HIV-1 protease. These cleavage products are not present in microvesicles from uninfected cells. Therefore, these processed proteins are most probably produced by HIV-1 protease digestion. The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins. KW - cytoskeleton KW - HIV-1 infections KW - human diseases KW - interactions KW - proteinases KW - proteins KW - proteolysis KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001697&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Endogenous\italic\Mtv\roman\-encoded superantigens are not required for development of murine AIDS. AU - McCarty, T. C. AU - Chattopadhyay, S. K. AU - Scherer, M. T. AU - Fredrickson, T. N. AU - Hartley, J. W. AU - Morse, H. C., III JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 11 SP - 8148 EP - 8150 SN - 0022-538X AD - McCarty, T. C.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972001943. Publication Type: Journal Article. Language: English. Number of References: 32 ref. N2 - Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumour virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder. KW - acquired immune deficiency syndrome KW - animal models KW - antigens KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunopathology KW - lymphocyte transformation KW - pathogenesis KW - mice KW - murine leukemia virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - AIDS KW - antigenicity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunogens KW - immunological reactions KW - immunopathogenesis KW - superantigens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001943&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses. AU - Bour, S. AU - Strebel, K. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 12 SP - 8285 EP - 8300 SN - 0022-538X AD - Bour, S.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460, USA. N1 - Accession Number: 19972001446. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - Identical enhancement of HIV-1 particle release was observed when either Vpu or the envelope glycoprotein of HIV-2ROD was provided in trans to a Vpu mutant of the NL-43(1) molecular clone of HIV-1. This effect was independent of the presence of the HIV-1 envelope protein. HIV-1 Vpu, as well as ROD10 Env, enhanced SIV particle release. The effects of Vpu and ROD10 Env on SIV particle release were indistinguishable and were observed in the context of full-length SIVmac239 and SIV-HIV chimeras. These results further demonstrate that ROD10 Env can functionally complement Vpu with respect to virus release. No evidence was found of CD4 degradation in the presence of ROD10 Env. KW - CD4 antigens KW - envelope glycoproteins KW - hiv infections KW - human diseases KW - microbiology KW - release KW - structural genes KW - Vpu protein KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - monkeys KW - retroviridae KW - simian immunodeficiency virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001446&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites. AU - Watkins, B. A. AU - Buge, S. AU - Aldrich, K. AU - Davis, A. E. AU - Robinson, J. AU - Reitz, M. S., Jr. AU - Robert-Guroff, M. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 12 SP - 8431 EP - 8437 SN - 0022-538X AD - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001461. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - This study analysed mutations at amino acid positions 281 and 582 in the HIV-1 envelope, where substitutions confer resistance to broadly reactive neutralizing antisera from seropositive individuals. Neither of these mutations lies within an antibody-binding site. The authors of this study conclude that the escape of HIV-1 from neutralization by polyclonal sera occurs through alterations at several different epitopes, generally resulting from single amino acid substitutions which influence envelope conformation. KW - amino acids KW - antibodies KW - binding KW - CD4 antigens KW - conformation KW - env gene KW - envelope protein gp120 KW - epitopes KW - genetic variation KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - mutations KW - neutralization KW - resistance KW - vaccines KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - antigenic determinants KW - body conformation KW - CD4 KW - genetic variability KW - genotypic variability KW - genotypic variation KW - gp120 KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001461&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes. AU - Chesebro, B. AU - Wehrly, K. AU - Nishio, J. AU - Perryman, S. JO - Journal of Virology JF - Journal of Virology Y1 - 1996/// VL - 70 IS - 12 SP - 9055 EP - 9059 SN - 0022-538X AD - Chesebro, B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19972001458. Publication Type: Journal Article. Language: English. Number of References: 50 ref. N2 - In this study the non-syncytium-inducing phenotype in T cells did not always correlate with macrophage tropism. Macrophage tropism appeared to depend on the presence of certain combinations of amino acids at five specific positions within and just outside of the V3 loop itself, whereas syncytium formation in lymphocytes was influenced by substitution of particular residues at two to four positions within V3. In most cases, different V3 amino acid positions were found to influence independently macrophage tropism and syncytium formation in T cells and position 13 was the only V3 location which appeared to influence simultaneously both macrophage tropism and syncytium formation in lymphocytes. KW - amino acids KW - clones KW - envelope glycoproteins KW - formation KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - lymphocytes KW - macrophages KW - mapping KW - microbiology KW - pathogenesis KW - phenotypes KW - syncytia KW - T lymphocytes KW - tropisms KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - cartography KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - V3 loop KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001458&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of in situ and invasive breast cancer in women aged under 45. AU - Weiss, H. A. AU - Brinton, L. A. AU - Brogan, D. AU - Coates, R. J. AU - Gammon, M. D. AU - Malone, K. E. AU - Schoenberg, J. B. AU - Swanson, C. A. JO - British Journal of Cancer JF - British Journal of Cancer Y1 - 1996/// VL - 73 IS - 10 SP - 1298 EP - 1305 SN - 0007-0920 AD - Weiss, H. A.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7374, USA. N1 - Accession Number: 19962005859. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health N2 - The incidence of in situ breast cancer in the USA has increased rapidly in recent years, even among young women. A population-based case-control study of 1616 breast cancer cases aged under 45 in the USA was used to examine risk factors for in situ, local and regional/distant tumours. Almost 60% of in situ tumours were detected by routine mammograms compared with 18% of local tumours and 8% of regional/distant tumours. After adjustment for screening history and established risk factors, family history of breast cancer in a first-degree relative and African-American race were associated with an increased risk of all stages of breast cancer. The associations with nulliparity, a previous breast biopsy and body mass index were significantly stronger for in situ tumours than for local or regional/distant disease. Alcohol consumption was associated with an increasing trend in risk of regional/distant tumours but not of earlier stage tumours, indicating that alcohol may be involved in late-stage events. Analyses by histological type of in situ tumours suggested that both ductal and lobular carcinoma in situ were associated with most established breast cancer risk factors, and the magnitude of association tended to be greater for the ductal form. KW - age differences KW - alcohol intake KW - breast KW - breast cancer KW - epidemiology KW - human diseases KW - neoplasms KW - risk factors KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - alcohol consumption KW - breasts KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005859&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental acute adult T cell leukemia-lymphoma is associated with thymic atrophy in human T cell leukemia virus type I infection. AU - Simpson, R. M. AU - Zhao TongMao AU - Hubbard, B. S. AU - Sawasdikosol, S. AU - Kindt, T. J. JO - Laboratory Investigation JF - Laboratory Investigation Y1 - 1996/// VL - 74 IS - 3 SP - 696 EP - 710 SN - 0023-6837 AD - Simpson, R. M.: Laboratory of Immunogenetics, The National Institute of Allergy and Infectious Disease, National Institutes of Health Twinbrook Facility, Rockville, Maryland, USA. N1 - Accession Number: 19972007606. Publication Type: Journal Article. Language: English. Number of References: 73 ref. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007606&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Membrane modifications in erythrocytes parasitized by Plasmodium falciparum. AU - Deitsch, K. W. AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1996/// VL - 76 IS - 1/2 SP - 1 EP - 10 SN - 0166-6851 AD - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960802859. Publication Type: Journal Article. Language: English. Number of References: 87 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - This review covers: membrane and transport processes of Plasmodium falciparum-infected erythrocytes; cytoadherence and sequestration of parasitized erythrocytes; antigenically variant adhesive molecules of P. falciparum-infected erythrocytes. KW - antigenic variation KW - cytoadherence KW - erythrocytes KW - host parasite relationships KW - immune evasion KW - malaria KW - membranes KW - parasites KW - reviews KW - plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - blood red cells KW - cell adhesion KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802859&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Distant metastasis from bilharzial bladder cancer. AU - Zaghloul, M. S. JO - Cancer JF - Cancer Y1 - 1996/// VL - 77 IS - 4 SP - 743 EP - 749 SN - 0008-543X AD - Zaghloul, M. S.: Radiotherapy Department, National Cancer Institute, Cairo, Egypt. N1 - Accession Number: 19960805386. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - A total of 357 patients with cancer of the bladder as a result of Schistosoma infection were treated at the National Cancer Institute in Cairo, Egypt, during the period 1981-1990. They were treated with either cystectomy alone, cystectomy preceded by a short course of preoperative radiotherapy (2000 cGy/5 fractions/1 week) or cystectomy followed by postoperative irradiation (5000 cGy/25 fractions/5 weeks or 3750 cGy/30 fractions/2 weeks). These patients were retrospectively analysed. The overall 5-year rate of distant metastasis was 23%, which was essentially the same in the 3 therapeutic groups. Both univariate and multivariate analyses revealed that the independent risk factors for distant metastasis were pelvic lymph node involvement, pathological stage and histopathological grade. Histological type and local pelvic recurrence appeared in the univariate analysis as working risk factors; however, they were proven by multivariate analysis to be dependent on other risk factors. Patients who had none of the independent risk factors had a lower rate of distant metastasis (11%) and a high local control rate (88%). Those who had more than one risk factor had a high distant metastasis rate (51%) and a low local control rate (41%), regardless of the treatment used. The identified independent risk factors determined both the distant metastasis and the local control rates. KW - bladder KW - disease course KW - helminths KW - histopathology KW - human diseases KW - lymph nodes KW - metastasis KW - neoplasms KW - parasites KW - pathology KW - radiotherapy KW - risk factors KW - schistosomiasis KW - surgery KW - urinary tract diseases KW - Africa KW - Egypt KW - man KW - Schistosoma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - bilharzia KW - bilharziasis KW - cancers KW - disease progression KW - Misr KW - parasitic worms KW - schistosomosis KW - Strigeida KW - urinary bladder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805386&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bimodal down-regulation of CD4 in cells expressing human immunodeficiency virus type 1 Vpu and Env. AU - Fujita, K. AU - Maldarelli, F. AU - Silver, J. JO - Journal of General Virology JF - Journal of General Virology Y1 - 1996/// VL - 77 IS - 10 SP - 2393 EP - 2401 SN - 0022-1317 AD - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972000013. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - Analysis of clones of HeLa cells stably expressing the HIV-1 envelope gene (env) and the HIV-1 receptor, CD4, revealed that individual clones consisted of 2 distinct populations of cells differing by approx. 10-fold in the level of surface CD4. When high and low CD4-expressing cells were separated by FACS, each subpopulation gave rise to a mixture of high and low CD4-expressing cells after several days in culture. High and low CD4-expressing subpopulations did not differ with respect to the amount of intracellular Env, but there was an inverse correlation between CD4 and another HIV-1 protein encoded by the same segment of the HIV genome, Vpu. High surface CD4 cells had high levels of intracellular CD4, largely in the perinuclear region, and low levels of Vpu with a diffuse staining pattern. Conversely, low surface CD4 cells had low levels of intracellular CD4 with a diffuse staining pattern, and high levels of Vpu, largely in the perinuclear region. Vectors containing mutant versions of either Env or Vpu failed to down-regulate surface CD4. KW - cd4 antigens KW - clones KW - env gene KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - microbiology KW - regulation KW - regulatory genes KW - structural genes KW - viral regulatory proteins KW - vpu gene KW - vpu protein KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - CD4 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000013&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of novel sequences and codon usage in Strongyloides stercoralis. AU - Moore, T. A. AU - Srinivasan Ramachandran AU - Gam, A. A. AU - Neva, F. A. AU - Lu WenHong AU - Saunders, L. AU - Williams, S. A. AU - Nutman, T. B. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1996/// VL - 79 IS - 2 SP - 243 EP - 248 SN - 0166-6851 AD - Moore, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960805467. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Helminthology N2 - cDNA libraries were constructed from infective filariform and rhabditiform larval stages of Strongyloides stercoralis using a technique that minimized RNA degradation and loss. 57 independent recombinants were characterized and sequenced, and codon usage was analysed. The genome was AT-rich (65% AT, 35% GC). A putative start codon (ATG) was identified in 3 of the 57 sequenced products. A stop codon was identified in all 57 sequences and in 15 of them was associated with a polyadenylated tail. A spliced leader sequence was not identified in any of the recombinants. BLAST analysis identified homologous protein-encoding genes from 28 sequences: 5 were homologous to ribosomal proteins, 14 were homologous to proteins with known function and 9 were homologous to helminth gene products of unknown function. The remaining 29 were identified as novel proteins. There was minimum overlap in the distribution of these homologous proteins between the filariform and rhabditiform larval libraries. Codon usage was significantly different from that in Caenorhabditis elegans and Onchocerca volvulus. There was a very strong bias for codons ending in A or T. [Nucleotide sequence data submitted to GenBank, accession numbers N21778 to N21834]. KW - codons KW - DNA libraries KW - helminths KW - larvae KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Rhabditida KW - Strongyloides stercoralis KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - coding triplet KW - codon usage KW - DNA sequences KW - filariform larvae KW - nematodes KW - parasitic worms KW - rhabditiform larvae KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples. AU - Kirkman, L. A. AU - Su XinZhuan AU - Wellems, T. E. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1996/// VL - 83 IS - 1 SP - 147 EP - 149 SN - 0014-4894 AD - Kirkman, L. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960804394. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology N2 - A simple method of visual colour scanning is reported by which Plasmodium falciparum clones can be rapidly and efficiently detected in the wells of microtitre plates. The method was used to isolate over 1000 recombinant progeny from a P. falciparum cross (HB3 X Dd2). Over 90% of colour-positive wells were found to contain viable parasites (0.5 to 5.0% parasitaemia), whereas the colour-negative wells consistently showed no parasites by microscopy. KW - blood KW - clones KW - genetic diversity KW - isolation KW - parasites KW - samples KW - techniques KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Other Invertebrate Culture (Not Aquaculture) (LL030) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Further studies on phorbol ester bioactivity in the Euphorbiaceae. AU - Beutler, J. A. AU - Alvarado-Lindner, A. B. AU - McCloud, T. G. JO - Annals of the Missouri Botanical Garden JF - Annals of the Missouri Botanical Garden Y1 - 1996/// VL - 83 IS - 4 SP - 530 EP - 533 SN - 0026-6493 AD - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute, Frederick Cancer Resarch and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19970303902. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 9026-43-1. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - The taxonomic distribution of phorbol esters was measured in 634 organic extracts, including 36 previously untested genera of the Euphorbiaceae, using a phorbol dibutyrate receptor binding assay (indicating phorbol esters which bind to protein kinase C). This receptor binding assay was more selective than other assays involving the use of whole animals (e.g. mouse ear irritancy assay). Phorbol bioactivity was newly detected in the genera Anthostema, Blachia, Borneodendron, Dichostemma, Spirostachys, Tapoides, Trigonostemon and Wetria. KW - anticarcinogenic properties KW - biological activity KW - chemotaxonomy KW - diterpenoids KW - enzyme activity KW - esters KW - plant composition KW - plant extracts KW - protein kinase KW - screening KW - taxonomy KW - Euphorbiaceae KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Anthostema KW - anti-carcinogenic properties KW - bioactivity KW - biochemical taxonomy KW - Blachia KW - Borneodendron KW - chemical constituents of plants KW - Dichostemma KW - screening tests KW - Spirostachys KW - systematics KW - Tapoides KW - Trigonostemon KW - Wetria KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Non-wood Forest Products (KK540) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970303902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis. AU - Mahanty, S. AU - Luke, H. E. AU - Kumaraswami, V. AU - Narayanan, P. R. AU - Vijayshekaran, V. AU - Nutman, T. B. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1996/// VL - 84 IS - 2 SP - 282 EP - 290 SN - 0014-4894 AD - Mahanty, S.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970804278. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 130068-27-8. Subject Subsets: Helminthology N2 - Responses to Brugia malayi microfilarial-derived antigens were assessed and compared to responses against adult male and mixed adult antigens of B. malayi in Madras, India (a region endemic for Wuchereria bancrofti filariasis), in 11 patients with lymphatic filariasis manifesting as elephantiasis and 8 asymptomatic microfilaraemic individuals. Proliferative responses to microfilarial and mixed adult antigens were markedly impaired in the asymptomatic individuals. T cell proliferative responses to adult male antigens did not differ significantly between the 2 groups. It was shown that the asymptomatic microfilaraemic individuals exhibited preferentially impaired Th1-type responses to microfilarial antigens and that microfilarial-induced IL-10 may be critical in the down regulation of specific Th1 responses. KW - antigens KW - cytokines KW - helminths KW - human diseases KW - immune response KW - interleukin 10 KW - lymphatic filariasis KW - microfilariae KW - parasites KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - stage specificity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804278&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased expression of the molecular chaperone BiP/GRP78 during the differentiation of a primitive eukaryote. AU - Luján, H. D. AU - Mowatt, M. R. AU - Conrad, J. T. AU - Nash, T. E. JO - Biology of the Cell JF - Biology of the Cell Y1 - 1996/// VL - 86 IS - 1 SP - 11 EP - 18 SN - 0248-4900 AD - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970801466. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Protozoology N2 - Immunological, biochemical and molecular biological approaches were used to analyse the expression of BiP/GRP78, an endoplasmic reticulum (ER)-resident chaperone, during the Giardia lamblia [Giardia duodenalis] life cycle. A MAb specific for Giardia BiP (immunoglobulin heavy chain-binding protein) permitted the visualization of the ER of this protozoan and showed that BiP expression increased simultaneously with the increased expression of CWPs (leucine-rich proteins) during encystation. However, in contrast to the 140-fold increase in levels of CWP transcripts, the steady-state level of BiP mRNA did not increase during encystation. Furthermore, potent inducers of BiP expression in higher eukaryotic cells, including agents that perturb the ER environment, did not affect BiP expression in Giardia. These results, when considered together with the profound changes that occur in the secretory pathway during Giardia encystation, indicate an important role for this molecular chaperone during the differentiation of this primitive eukaryote. KW - development KW - differentiation KW - endoplasmic reticulum KW - monoclonal antibodies KW - parasites KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801466&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retrovirus-elicited interleukin-12 and tumour necrosis factor-α as inducers of interferon-γ-mediated pathology in mouse AIDS. AU - Giese, N. A. AU - Gazzinelli, R. T. AU - Actor, J. K. AU - Morawetz, R. A. AU - Sarzotti, M. AU - Morse, H. C. III JO - Immunology JF - Immunology Y1 - 1996/// VL - 87 IS - 3 SP - 467 EP - 474 SN - 0019-2805 AD - Giese, N. A.: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962008123. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9008-11-1, 308079-78-9. KW - acquired immune deficiency syndrome KW - animal models KW - human diseases KW - immune response KW - interferon KW - interleukin 12 KW - pathogenesis KW - tumour necrosis factor KW - mice KW - Murine leukemia virus KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - cachectin KW - cachexin KW - immunity reactions KW - immunological reactions KW - murine leukaemia virus KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs. AU - Humphrey, R. W. AU - O'Brien, T. R. AU - Newcomb, F. M. AU - Nishihara, H. AU - Wyvill, K. M. AU - Ramos, G. A. AU - Saville, M. W. AU - Goedert, J. J. AU - Straus, S. E. AU - Yarchoan, R. JO - Blood JF - Blood Y1 - 1996/// VL - 88 IS - 1 SP - 297 EP - 301 SN - 0006-4971 AD - Humphrey, R. W.: Medicine Branch, National Cancer Institute, Bethesda, MD 20892-1906, USA. N1 - Accession Number: 19962007673. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 9007-49-2, 63585-09-1, 82410-32-0. KW - aetiology KW - DNA KW - foscarnet sodium KW - ganciclovir KW - HIV infections KW - human diseases KW - human herpesviruses KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - causal agents KW - deoxyribonucleic acid KW - etiology KW - human herpesvirus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - trisodium phosphonoformate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007673&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Non-Hodgkin's lymphoma and sunlight. AU - Hartge, P. AU - Devesa, S. S. AU - Grauman, D. AU - Fears, T. R. AU - Fraumeni, J. F. Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 5 SP - 298 EP - 300 SN - 0027-8874 AD - Hartge, P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19962004994. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health N2 - The results are presented of a study in the USA using mortality data for cutaneous melanoma, non-melanoma skin cancer and non-Hodgkin's lymphoma (NHL) for the period 1970-1989. The data suggest that the overall geographic variation in mortality rates for NHL in the USA does not reflect higher levels of UV radiation, however, the survey could not exclude a subtle association between NHL and sunlight, (for example, if UV radiation acted as a cofactor, if only particular cell types of NHL were affected, or if intermittent rather than cumulative UV radiation exposure altered risk). The study showed that sunlight does not bear the same clear relationship to NHL evident in the geographic variation of cutaneous melanoma and non-melanoma skin cancers. It is concluded that further investigation of the continuing pattern of high mortality rates for NHL in the Plains, the Midwest and certain coastal areas is warranted. KW - climate KW - cutaneous melanoma KW - environment KW - epidemiology KW - human diseases KW - neoplasms KW - non-Hodgkin's lymphoma KW - risk factors KW - skin KW - skin cancer KW - ultraviolet radiation KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - dermis KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Meteorology and Climate (PP500) KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004994&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. AU - Cereseto, A. AU - Diella, F. AU - Mulloy, J. C. AU - Cara, A. AU - Michieli, P. AU - Grassmann, R. AU - Franchini, G. AU - Klotman, M. E. JO - Blood JF - Blood Y1 - 1996/// VL - 88 IS - 5 SP - 1551 EP - 1560 SN - 0006-4971 AD - Cereseto, A.: Laboratory of Tumor Cell Biology, Laboratory of Tumor Immunology and Biology, Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972001678. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Registry Number: 63231-63-0. KW - cell cycle KW - cell lines KW - HTLV infections KW - human diseases KW - immune response KW - kinases KW - lymphocyte transformation KW - pathogenesis KW - proteins KW - regulation KW - responses KW - RNA KW - T lymphocytes KW - Tax protein KW - transcription KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - DNA transcription KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - immunity reactions KW - immunological reactions KW - ribonucleic acid KW - T cells KW - tumour suppressor gene p53 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Importance of α-carotene, β-carotene, and other phytochemicals in the etiology of lung cancer. AU - Ziegler, R. G. AU - Colavito, E. A. AU - Hartge, P. AU - McAdams, M. J. AU - Schoenberg, J. B. AU - Mason, T. J. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 9 SP - 612 EP - 615 SN - 0027-8874 AD - Ziegler, R. G.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961407529. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition; Public Health KW - aetiology KW - antineoplastic agents KW - carotenoids KW - lung cancer KW - lungs KW - neoplasms KW - vegetables KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancer sites KW - cancers KW - causal agents KW - cytotoxic agents KW - etiology KW - tetraterpenoids KW - vegetable crops KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407529&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relative weight, weight change, height, and breast cancer risk in Asian-American women. AU - Ziegler, R. G. AU - Hoover, R. N. AU - Nomura, A. M. Y. AU - West, D. W. AU - Wu, A. H. AU - Pike, M. C. AU - Lake, A. J. AU - Horn-Ross, P. L. AU - Kolonel, L. N. AU - Siiteri, P. K. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 10 SP - 650 EP - 660 SN - 0027-8874 AD - Ziegler, R. G.: National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892-7374, USA. N1 - Accession Number: 19961407481. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Human Nutrition; Public Health N2 - The roles of adult height, adiposity and weight change in breast cancer aetiology were examined. Subjects were women of Chinese, Japanese and Filipino ethnicities, aged 20-55 years, living in San Francisco-Oakland, Los Angeles and Oahu, USA during April 1, 1983, through June 30, 1987. 70% of 852 eligible subjects and 75% of 1287 eligible control subjects were interviewed from August 1985 through February 1989. Subjects were asked about current height, usual adult weight and usual weight in each decade of life, excluding the most recent 3 years and any periods of pregnancy. Height, recent adiposity (weight in the current decade of life/height1.5) and recent weight change (between the current and preceding decades of life) were strong predictors of breast cancer risk after adjustment was made for accepted breast cancer risk factors. Risk doubled (relative risk (RR) = 2.01; 95% confidence interval (CI) = 1.16-3.49) over the 7-inch range in height (two-sided P for trend = 0.003), with comparable effects in both premenopausal and postmenopausal women. Except for reduced risk in the heavy, younger women (weight/height1.5 >29 kg/m1.5 and <40 years old), risk was positively associated with usual adult adiposity. Trends in risk became more striking as adiposity in each succeeding decade of adult life was considered. Women in their 50s and in the top quintile of adiposity for their age group had twice the breast cancer risk (RR = 2.13; 95% CI = 1.17-3.87) of women in the bottom quintile (two-sided P for trend = 0.004). Women in their 50s, above the median adiposity for their age group, and with a recent gain of more than 10 pounds had three times the risk (RR = 3.01; 95% CI = 1.45-6.25) of women below the median adiposity and with no recent weight change. Recent weight loss was consistently associated with reduced risk (RRs of about 0.7) relative to no recent weight change. Adult adiposity, weight change, and height are critical determinants of breast cancer risk. Increased adiposity and weight gain in the decade preceding diagnosis are especially influential, suggesting that excess weight may function as a late stage promoter. Weight maintenance and/or reduction as an adult, possibly accompanied by specific changes in diet and physical activity, may have a significant and rapid impact on breast cancer risk. KW - body measurements KW - body weight KW - breast KW - breast cancer KW - height KW - mammary gland neoplasms KW - neoplasms KW - risk KW - risk factors KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - mammary tumour KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407481&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome. AU - Coté, T. R. AU - Manns, A. AU - Hardy, C. R. AU - Yellin, F. J. AU - Hartge, P. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 10 SP - 675 EP - 679 SN - 0027-8874 AD - Coté, T. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006512. Publication Type: Journal Article. Corporate Author: AIDS/Cancer Study Group Language: English. Number of References: 16 ref. Subject Subsets: Public Health N2 - AIDS and cancer registry reports at 9 state and local health departments in the USA were linked and the demographics, histology and survival of brain lymphoma cases among persons with or without AIDS were compared. 50 989 AIDS registry reports were matched to 859 398 cancer registry reports (data 1981-90) and 431 patients with both AIDS and brain lymphoma were identified. Among subjects with AIDS, those developing brain lymphoma vs. those without brain lymphoma were more likely to be white and had homosexuality as their only HIV risk factor. Of the 431 patients, 223 developed brain lymphomas during 47 465 person-years of observation after diagnosis of AIDS. The absolute incidence rate of brain lymphoma among persons with AIDS was 4.7/1000 person-years, 3600-fold higher than the base-line rate in the general population. During 1980-89, overall counts of brain lymphoma increased 9-fold. Most of this increase was derived from persons with AIDS, but a substantial increase also occurred among persons without AIDS (0.04/100 000 in 1982 to 0.28/100 000 in 1989). The median survival was shortest for persons with AIDS and brain lymphoma (2 months), was intermediate for persons with brain lymphoma without AIDS (5-7 months), and was longest for those with AIDS without brain lymphoma (14 months). KW - acquired immune deficiency syndrome KW - brain KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphoma KW - North America KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - cerebrum KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006512&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serologic association between human papillomavirus type 16 infection and esophageal cancer in Shaanxi province, China. AU - Han ChengLong AU - Qiao GuiBin AU - Hubbert, N. L. AU - Li LiangShou AU - Sun ChangSheng AU - Wang Yan AU - Yan MingXiao AU - Xu DeZhong AU - Li YuanGui AU - Lowy, D. R. AU - Schiller, J. T. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 20 SP - 1467 EP - 1471 SN - 0027-8874 AD - Han ChengLong: Laboratory of Cellular Oncology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972001894. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Tropical Diseases N2 - A case-control study was conducted in Shaanxi Province, China, an area with a population at high risk for oesophageal cancer, to assess the association of this disease with infection by human papillomavirus type 16 (HPV 16). 90 individuals with oesophageal cancer and 121 cancer-free control subjects were identified among the patients in 2 hospitals in Xi'an. Blood specimens were drawn from all study subjects, and serum was isolated by routine methods. The presence of HPV 16 antibodies in serum samples was determined by use of an ELISA that used baculovirus-derived HPV 16 virus-like particles as the antigen. A similar ELISA that used bovine papillomavirus type 1 (BPV 1) virus-like particles as the antigen controlled for the specificity of HPV 16 seroreactivity. Data from the HPV 16 and the BPV 1 assays were normalized with respect to results obtained in each assay with a control serum of known HPV 16 seroreactivity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to examine the association between HPV 16 seroreactivity and oesophageal cancer. Reported P values are two-sided. The mean seroreactivity to HPV 16 virus-like particles was significantly higher for the cancer patients than for the control subjects (mean value ± standard deviation = 0.85 ± 0.22 vs. 0.74 ± 0.18; P <0.0001). When the cancer patients and control subjects were compared by sex and age groups, the differences in mean seroreactivity remained statistically significant. The difference in mean seroreactivity to BPV 1 virus-like particles between cancer patients and control subjects was not statistically significant (0.81 ± 0.28 vs. 0.88 ± 0.32; P = 0.12); this result was not altered when sex and age groups were compared. By use of a cutoff point for HPV 16 seropositivity that was established in studies of cervical neoplasia, 24% of the cancer patients were seropositive compared with 7% of the control subjects, yielding a sex-and age-adjusted OR of 4.5 (95% CI = 1.8-11.9). In general, the OR for oesophageal cancer increased with increasing HPV 16 seroreactivity. It is concluded that HPV 16 infection may be a risk factor for oesophageal cancer. Further studies of the association between HPV 16 infection and the incidence of oesophageal cancer are needed. KW - aetiology KW - ELISA KW - epidemiology KW - human diseases KW - infections KW - neoplasms KW - oesophageal cancer KW - oesophagus KW - risk factors KW - viral diseases KW - Asia KW - China KW - Shaanxi KW - human papillomavirus 16 KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Papillomaviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - North Western China KW - China KW - cancer sites KW - cancers KW - causal agents KW - enzyme linked immunosorbent assay KW - esophageal cancer KW - esophagus KW - etiology KW - human papillomavirus KW - Papovaviridae KW - People's Republic of China KW - Shensi KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001894&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent trends in U.S. breast cancer incidence, survival, and mortality rates. AU - Chu, K. C. AU - Tarone, R. E. AU - Kessler, L. G. AU - Ries, L. A. G. AU - Hankey, B. F. AU - Miller, B. A. AU - Edwards, B. K. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 21 SP - 1571 EP - 1579 SN - 0027-8874 AD - Chu, K. C.: Special Population Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972002698. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Public Health N2 - Mortality data from the National Center for Health Statistics and incidence and survival data by extent of disease from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute, all stratified by patient age, were examined using statistical-regression techniques to determine trends in breast cancer up to 1993. The age-adjusted breast cancer mortality rate for white females in the USA decreased 6.8% from 1989 to 1993. A significant decrease in the slope of the mortality trend of approximately 2% per year was observed in every decade of age from 40 to 79 years of age. Trends in incidence rates were also similar among these age-groups: localized disease rates increased rapidly from 1982 to 1987 and stabilized or increased more slowly thereafter; regional disease rates decreased after 1987; and distant disease rates remained constant over the past 20 years. Three-year relative survival rates increased steadily and significantly for localized and regional disease from 1980 through 1989 for all ages, with no evidence of an increase in slope in the late 1980s. The decrease in the diagnosis of regional disease in the late 1980s in women >40 years probably reflects the increased use of mammography earlier in the 1980s. The increase in survival rates, particularly for regional disease, probably reflects improvements in systemic adjuvant therapy. Statistical modelling indicates that the recent decrease in breast cancer mortality is too rapid to be explained only by the increased use of mammography; likewise, there has been no equivalent dramatic increase in survival rates that would implicate therapy alone. Thus, indications are that both are involved in the recent rapid decline in breast cancer mortality rates in the USA. KW - breast KW - breast cancer KW - diagnosis KW - epidemiology KW - human diseases KW - incidence KW - mortality KW - neoplasms KW - screening KW - survival KW - trends KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - death rate KW - screening tests KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002698&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changing trends in U.S. prostate cancer incidence rates. AU - Merrill, R. M. AU - Potosky, A. L. AU - Feuer, E. J. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 22 SP - 1683 EP - 1685 SN - 0027-8874 AD - Merrill, R. M.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19972003085. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health N2 - An analysis of prostate cancer incidence rates in the USA is presented. KW - epidemiology KW - human diseases KW - incidence KW - men KW - neoplasms KW - prostate KW - prostate cancer KW - screening KW - trends KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - screening tests KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003085&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cigarette smoking among US adults by state and region: estimates from the current population survey. AU - Shopland, D. R. AU - Hartman, A. M. AU - Gibson, J. T. AU - Mueller, M. D. AU - Kessler, L. G. AU - Lynn, W. R. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1996/// VL - 88 IS - 23 SP - 1748 EP - 1758 SN - 0027-8874 AD - Shopland, D. R.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19972002893. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health N2 - Smoking prevalence rates among men and women were determined by region and for each of the 50 states of the USA and the District of Columbia from census survey data collected in 1992 and 1993. These rates were compared with rates determined in 1985. Current smoking rates (every day and some days combined) based on 266 988 adults interviewed in 1992-1993 were calculated. Substantial geographic variation existed in rates of current cigarette use among adults within the USA. In general, adults in the southern USA had higher rates of smoking and adults in the western states had lower rates of smoking than adults in the rest of the country, although differences in smoking behaviour between men and women and among various racial and ethnic populations strongly influenced these patterns. Only Kentucky and West Virginia exhibited adult smoking rates (men and women combined) of 30% or higher in 1992-1993; in contrast, in 1985, such rates were reported from 20 states. The only states in which the prevalence was below 20% in 1992-1993 were Utah (17.1%) and California (19.5%). Rates approaching 20% were reported from New Jersey (20.7%), Massachusetts (21.5%), and Nebraska, New York, and Hawaii (22.0% each) in 1992-1993. Rhode Island experienced the greatest relative decline in smoking prevalence from 1985 to 1992-1993, with a calculated relative change of -30.7% (based on a change in rate from 33.5% to 23.2%), followed by Delaware (-25.9%), the District of Columbia and New Jersey (-23.9% each), Connecticut (-23.2%), California (-22.9%), Alaska (-22.8%), Georgia (-22.6%), Massachusetts (-22.1%), and New York (-22.0%). It was concluded that smoking rates are not uniform in the USA but vary considerably from state to state, even within the same region of the country. KW - cigarettes KW - epidemiology KW - geographical variation KW - populations KW - statistics KW - tobacco smoking KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002893&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. AU - Salem, N., Jr. AU - Wegher, B. AU - Mena, P. AU - Uauy, R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 1 SP - 49 EP - 54 SN - 0027-8424 AD - Salem, N., Jr.: Laboratory of Membrane Bochemistry and Biophycs, National Institute of Alcohol BAuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 19961408488. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 506-32-1, 25167-62-8. Subject Subsets: Human Nutrition N2 - This study explores the capacity of infants to convert 18-carbon essential fatty acids to their elongated and desaturated forms, in vivo. A newly developed gas chromatography/negative chemical ionization/mass spectrometry method employing ²H-labelled essential fatty acids allowed assessment of this in vivo conversion with very high sensitivity and selectivity. The results demonstrate that infants have the capacity to convert dietary essential fatty acids administered enterally as ²H-labelled ethyl esters to their longer-chain derivatives, transport them to plasma, and incorporate them into membrane lipids. The in vivo conversion of linolenic acid (18:2n-6) to arachidonic acid (20:4n-6) is demonstrated in man. All elongases/desaturases necessary for the conversion of linolenic acid (18:3n-3) to docosahexaenoic acid (22:6n-3) are also active in the first week after birth. Although the absolute amounts of n-3 fatty acid metabolites accumulated in plasma are greater than those of the n-6 family, estimates of the endogenous pools of 18:2n-6 and 18:3n-3 indicate that n-6 fatty acid conversion rates are greater than those of the n-3 family. While these data clearly demonstrate the capability of infants to biosynthesize 22:6n-3, a lipid that is required for optimal neural development, the amounts produced in vivo from 18:3n-3 may be inadequate to support the 22:6n-3 level observed in breast-fed infants. KW - arachidonic acid KW - docosahexaenoic acid KW - essential fatty acids KW - infants KW - metabolism KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - eicosatetraenoic acid KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408488&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells. AU - Thornton, A. M. AU - Buller, R. M. L. AU - DeVico, A. L. AU - Wang, I. M. AU - Ozato, K. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 1 SP - 383 EP - 387 SN - 0027-8424 AD - Thornton, A. M.: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962004964. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9008-11-1. KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - infections KW - interferon KW - monocytes KW - Human immunodeficiency virus 1 KW - vaccinia virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004964&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. AU - Wu YiMin AU - Kirkman, L. A. AU - Wellems, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 3 SP - 1130 EP - 1134 SN - 0027-8424 AD - Wu YiMin: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19960802271. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9002-03-3, 9007-49-2, 58-14-0. Subject Subsets: Protozoology N2 - Plasmodium falciparum parasites were transformed with plasmids containing P. falciparum or Toxoplasma gondii dihydrofolate reductase-thymidylate synthase (dhfr-ts) coding sequences that confer resistance to pyrimethamine. Under pyrimethamine pressure, transformed parasites were obtained that maintained the transfected plasmids as unrearranged episomes for several weeks. These parasite populations were replaced after 2 to 3 months by parasites that had incorporated the transfected DNA into nuclear chromosomes. Depending upon the particular construct used for transformation, homologous integration was detected in the P. falciparumdhfr-ts locus (chromosome 4) or in hrp3 and hrp2 sequences that were used in the plasmid constructs as gene control regions (chromosomes 13 and 8, respectively). Transformation by homologous integration prepares the way for targeted gene alterations and deletions that will advance understanding of P. falciparum. KW - antimalarials KW - antiprotozoal agents KW - chromosomes KW - dihydrofolate reductase KW - DNA KW - drug resistance KW - genetic transformation KW - integration KW - molecular genetics KW - nucleotide sequences KW - parasites KW - plasmids KW - pyrimethamine KW - transfection KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - tetrahydrofolate dehydrogenase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. AU - Bamford, R. N. AU - Battiata, A. P. AU - Burton, J. D. AU - Sharma, H. AU - Waldmann, T. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 7 SP - 2897 EP - 2902 SN - 0027-8424 AD - Bamford, R. N.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA. N1 - Accession Number: 19962006783. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 63231-63-0. N2 - We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires interleukin (IL) 2 receptor Β-subunit expression for its action. Using anti-cytokine anti-bodies, we demonstrated that IL-T is identical to the simultaneously described IL-15. When compared to activated monocytes, IL-15 mRNA expression was 6- to 10-fold greater in HuT-102 cells. The predominant IL-15 message from HuT-102 is a chimeric mRNA joining a segment of the R region of the long terminal repeat of HTLV-I and the 5′-untranslated region (UTR) of IL-15. Normally, by alternative splicing, this 118-nucleotide R element represents the most 5′ region of several HTLV-I transcripts including tax, rex, and env. The introduction of the R element eliminated over 200 nucleotides of the IL-15 5′-UTR, including 8 of 10 upstream AUGs that are present in normal IL-15 messages. On analysis of the 5′-UTR of normal IL-15, we demonstrated that the presence of these 10 upstream AUGs interferes with IL-15 mRNA translation. Thus, IL-15 synthesis by the adult T-cell leukemia line HuT-102 involves an increase in IL-15 mRNA transcription and translation secondary to the production of an HTLV-I R element fusion message that lacks many upstream AUGs. KW - gene expression KW - HTLV-I infections KW - human diseases KW - RNA KW - translation KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - interleukin-15 KW - ribonucleic acid KW - RNA translation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006783&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. AU - Levine, M. AU - Conry-Cantilena, C. AU - Wang, Y. AU - Welch, R. W. AU - Washko, P. W. AU - Dhariwal, K. R. AU - Park, J. B. AU - Lazarev, A. AU - Graumlich, J. F. AU - King, J. AU - Cantilena, L. R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 8 SP - 3704 EP - 3709 SN - 0027-8424 AD - Levine, M.: Molecular and Clinical Nutrition Section, Building 10, Room 4D52, MSC 1372, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-1372, USA. N1 - Accession Number: 19971402078. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 69-93-2, 50-81-7. Subject Subsets: Human Nutrition N2 - An in-hospital depletion-repletion study was conducted in 7 healthy men (20-26 years old) who were hospitalized for 4-6 months and consumed a diet containing <5 mg of vitamin C daily. Steady-state plasma and tissue concentrations were determined at 7 daily doses of vitamin C from 30 to 2500 mg. Vitamin C steady-state plasma concentrations as a function of dose displayed sigmoid kinetics. The steep portion of the curve occurred between the 30- and 100-mg daily dose, the current RDA of 60 mg daily was on the lower third of the curve, the first dose beyond the sigmoid portion of the curve was 200 mg daily, and complete plasma saturation occurred at 1000 mg daily. Neutrophils, monocytes and lymphocytes saturated at 100 mg daily and contained concentrations at least 14-fold higher than plasma. Availability was complete for 200 mg of vitamin C as a single dose. No vitamin C was excreted in urine of 6 of 7 men until the 100-mg dose. At single doses of 500 mg and higher, availability declined and the absorbed amount was excreted. Oxalate and urate excretion were elevated at 1000 mg of vitamin C daily compared to lower doses. Based on these data and Institute of Medicine (USA) criteria, the current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables. Safe doses of vitamin C are less than 1000 mg daily, and vitamin C daily doses above 400 mg have no evident value. KW - ascorbic acid KW - estimation KW - fruits KW - lymphocytes KW - monocytes KW - neutrophils KW - oxalates KW - recommended dietary allowances KW - uric acid KW - vegetables KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RDA KW - recommended dietary intakes KW - vegetable crops KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. AU - Lane, M. A. AU - Baer, D. J. AU - Rumpler, W. V. AU - Weindruch, R. AU - Ingram, D. K. AU - Tilmont, E. M. AU - Cutler, R. G. AU - Roth, G. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 9 SP - 4159 EP - 4164 SN - 0027-8424 AD - Lane, M. A.: Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA. N1 - Accession Number: 19971412708. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition; Animal Nutrition N2 - Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad libitum (controls) and was reduced by ~0.5°C in age-matched monkeys subjected to 6 years of a 30% reduction in energy intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0°C. Indirect calorimetry showed that 24-h energy expenditure was reduced by approximately 24% during short-term energy restriction (ER). The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during ER. The reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by ER, now strengthening the possibility that ER may exert beneficial effects in primates analogous to those observed in rodents. KW - age KW - aging KW - body temperature KW - calorimetry KW - energy deprivation KW - energy intake KW - energy metabolism KW - monkeys KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - calorimetric methods KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. AU - Graziosi, C. AU - Gantt, K. R. AU - Vaccarezza, M. AU - Demarest, J. F. AU - Daucher, M. AU - Saag, M. S. AU - Shaw, G. M. AU - Quinn, T. C. AU - Cohen, O. J. AU - Welbon, C. C. AU - Pantaleo, G. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 9 SP - 4386 EP - 4391 SN - 0027-8424 AD - Graziosi, C.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1876, USA. N1 - Accession Number: 19962007611. Publication Type: Journal Article. Language: English. Number of References: 32 ref. KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - interleukins KW - kinetics KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007611&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus (HIV) type 2-mediated inhibition of HIV type 1: a new approach to gene therapy of HIV infection. AU - Arya, S. K. AU - Gallo, R. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 9 SP - 4486 EP - 4491 SN - 0027-8424 AD - Arya, S. K.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962007614. Publication Type: Journal Article. Language: English. Number of References: 32 ref. KW - gene therapy KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - susceptibility KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007614&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trafficking of Plasmodium chabaudi adami-infected erythrocytes within the mouse spleen. AU - Yadava, A. AU - Kumar, S. AU - Dvorak, J. A. AU - Milon, G. AU - Miller, L. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 10 SP - 4595 EP - 4599 SN - 0027-8424 AD - Yadava, A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801480. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Protozoology N2 - It was found that in Plasmodium chabaudi adami infections in mice, crisis (the time of rapidly dropping parasitaemia) was abrogated by splenectomy, indicating the role of spleen in parasite killing. To determine the potential effects of different vascular beds in parasite killing, the distribution of parasitized erythrocytes and bacteria in the spleens of P. chabaudi adami-infected mice was studied during precrisis (a period of rising parasitaemia) and during crisis. After iv injection, bacteria were localized predominantly in the marginal zone. In contrast, parasitized erythrocytes were found in the red pulp. It was also found that during precrisis, a time of no immunity, the uptake of radiolabelled infected erythrocytes by the spleen was increased, not decreased. It is implied that no change occurs in the flow of parasitized erythrocytes through the spleen during the transition to an immune state (crisis). It is suggested that immune effector mechanisms, not circulatory changes, account for spleen-dependent parasite killing during a P. chabaudi adami infection in mice. KW - erythrocytes KW - experimental infections KW - immunity KW - laboratory animals KW - parasites KW - spleen KW - mice KW - Plasmodium chabaudi KW - Plasmodium chabaudi adami KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium chabaudi KW - blood red cells KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801480&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infectivity of chimeric human T-cell leukemia virus type I molecular clones assessed by naked DNA inoculation. AU - Zhao, M. AU - Robinson, M. A. AU - Bowers, F. S. AU - Kindt, T. J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 13 SP - 6653 EP - 6658 SN - 0027-8424 AD - Zhao, M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 19972007812. Publication Type: Journal Article. Language: English. Number of References: 28 ref. N2 - Two human T-cell leukemia virus type I (HTLV-I) molecular clones, K30p and K34p were derived from HTLV-I-infected rabbit cell lines. K30p and K34p differ by 18 bp with changes in the long terminal repeats (LTRs) as well as in the gag, pol, and rex but not tax or env gene products. Cells transfected with clone K30p were infectious in vitro and injection of the K30p transfectants or naked K30p DNA into rabbits leads to chronic infection. In contrast, K34p did not mediate infection in vitro or in vivo, although the cell line from which it was derived is fully infectious and K34p transfectants produce intact virus particles. To localize differences involved in the ability of the clones to cause infection, six chimeric HTLV-I clones were constructed by shuffling corresponding fragments containing the substitutions in the LTRs, the gag/pol region and the rex region between K30p and K34p. Cells transfected with any of the six chimeras produced virus, but higher levels of virus were produced by cells transfected with those constructs containing the K30p rex region. Virus production was transient except in cells transfected with K30p or with a chimera consisting of the entire protein coding region of K30p flanked by K34p LTRs; only the transfectants showing persistent virus production mediated in vitro infection. In vivo infection in rabbits following intramuscular DNA injection was mediated by K30p as well as by a chimera of K30p containing the K34p rex gene. Comparisons revealed that virus production was greater and appeared earlier in rabbits injected with K30p. These data suggest that several defects in the K34p clone preclude infectivity and furthermore, provide systems to explore functions of HTLV-I genes. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro. AU - Feng YaXiong AU - Copeland, T. D. AU - Henderson, L. E. AU - Gorelick, R. J. AU - Bosche, W. J. AU - Levin, J. G. AU - Rein, A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 15 SP - 7577 EP - 7581 SN - 0027-8424 AD - Feng YaXiong: Retroviral Genetics Section, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001061. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 63231-63-0. N2 - After a retrovirus particle is released from the cell, the dimeric genomic RNA undergoes a change in conformation. The authors have previously proposed that this change, termed maturation of the dimer, is due to the action of nucleocapsid (NC) protein on the RNA within the virus particle. They now report that treatment of a 345-base synthetic fragment of Harvey sarcoma virus RNA with recombinant or synthetic HIV-1 NC protein converts a less stable form of dimeric RNA to a more stable form. This phenomenon thus appears to reproduce the maturation of dimeric retroviral RNA in a completely defined system in vitro. According to the authors, maturation of dimeric RNA within a retrovirus particle is the first example of action of an "RNA chaperone" protein in vivo. Studies with mutant NC proteins suggest that the activity depends upon basic amino acid residues flanking the N-terminal zinc finger and upon residues within the N-terminal finger, including an aromatic amino acid, but do not require the zinc finger structures themselves. KW - amino acids KW - HIV-1 infections KW - human diseases KW - maturation KW - nucleocapsid proteins KW - proteins KW - RNA KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001061&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cholesterol starvation induces differentiation of the intestinal parasite Giardia lamblia. AU - Luján, H. D. AU - Mowatt, M. R. AU - Byrd, L. G. AU - Nash, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 15 SP - 7628 EP - 7633 SN - 0027-8424 AD - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970800972. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 57-88-5. Subject Subsets: Protozoology; Tropical Diseases N2 - The stimulus for cyst formation in Giardia lamblia [G. duodenalis] was investigated. Cyst formation was induced in vitro when trophozoites were starved of cholesterol. Expression of cyst wall proteins was detected within encystation-specific secretory vesicles 90 minutes after the cells were placed in lipoprotein-deficient TYI-S-33 medium. Four cloned lines derived from 2 Giardia isolates were tested, and all formed cysts similarly. Addition of cholesterol, low density or very low density lipoproteins to the lipoprotein-deficient culture medium inhibited the expression of cyst wall proteins, the generation of encystation-specific vesicles and cyst wall biogenesis. In contrast, high density lipoproteins, phospholipids, bile salts and fatty acids had little or no effect. The results indicate that cholesterol starvation is necessary and sufficient for the stimulation of Giardia encystation in vitro and, probably, in the intestine of mammalian hosts. KW - cholesterol KW - culture media KW - development KW - developmental stages KW - in vitro KW - life history KW - lipoproteins KW - parasites KW - proteins KW - starvation KW - trophozoites KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cysts KW - growth phase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800972&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function. AU - Smith, S. M. AU - Markham, R. B. AU - Jeang KuanTeh JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 15 SP - 7955 EP - 7960 SN - 0027-8424 AD - Smith, S. M.: Molecular Virology Section. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972001063. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 82410-32-0, 9002-06-6. N2 - The development of an effective vaccine for HIV-1 would be a major advance toward controlling the AIDS pandemic. Several disparate strategies for a safe and effective HIV vaccine have been proposed. Recent data suggest that loss-of-function live-attenuated virus could be a safe lentivirus vaccine. The authors propose a gain-of-function approach that can complement loss-of-function in enhancing the safety profile of a live-attenuated virus. An example is described in which ganciclovir (GCV) was used to treat effectively nef(-)HIV-1 engineered to express herpes simplex virus (HSV-1) thymidine kinase (TK). This treatment was found to be highly efficient in controlling HIV-1 spread in tissue culture and in a small animal (hu-PBL-SCID) model. KW - animal models KW - antiviral agents KW - drug therapy KW - ganciclovir KW - gene therapy KW - HIV-1 infections KW - human diseases KW - immune response KW - mutations KW - nef gene KW - safety KW - thymidine kinase KW - vaccines KW - Human herpesvirus 1 KW - Human immunodeficiency virus 1 KW - mice KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - herpes simplex virus 1 KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001063&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma invasion: the parasitophorous vacuole is formed from host cell plasma membrane and pinches off via a fission pore. AU - Suss-Toby, E. AU - Zimmerberg, J. AU - Ward, G. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 16 SP - 8413 EP - 8418 SN - 0027-8424 AD - Suss-Toby, E.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19970800458. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Protozoology N2 - To test whether the parasitophorous vacuole membrane (PVM) formed by Toxoplasma gondii is derived from host cell membrane or from lipids secreted by the parasite, time-resolved capacitance measurements and video microscopy were used to assay host cell surface area during cell invasion. No significant change was observed in host cell surface area during PVM formation, demonstrating that the PVM consists primarily of invaginated host cell membrane. Pinching-off of the PVM from the host cell membrane occurred after an unexpected delay (34-305 seconds) and was seen as a 0.219 ± 0.006 pF drop in capacitance, which corresponded well to the predicted surface area of the entire PVM (30-33 µm²). The formation and closure of a fission pore connecting the extracellular medium and the vacuolar space was detected as the PVM pinched off. This final stage of parasite invasion was accomplished without any breach in cell membrane integrity. KW - cell cultures KW - cell invasion KW - cell membranes KW - host parasite relationships KW - microscopy KW - parasites KW - plasma membranes KW - vacuoles KW - protozoa KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cell membrane KW - parasite host relationships KW - parasitophorous vacuole KW - plasmalemma KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800458&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum. AU - Silva, A. M. AU - Lee, A. Y. AU - Gulnik, S. V. AU - Majer, P. AU - Collins, J. AU - Bhat, T. N. AU - Collins, P. J. AU - Cachau, R. E. AU - Luker, K. E. AU - Gluzman, I. Y. AU - Francis, S. E. AU - Oksman, A. AU - Goldberg, D. E. AU - Erickson, J. W. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 19 SP - 10034 EP - 10039 SN - 0027-8424 AD - Silva, A. M.: Structural Biochemistry Program, National Cancer Institute/SAIC, P.O. Box B, Frederick, MD 21702, USA. N1 - Accession Number: 19970805680. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology N2 - Plasmodium falciparum encodes 2 homologous aspartic proteases, plasmepsins I and II, which are essential components of its haemoglobin-degradation pathway and are novel targets for antimalarial drug development. The crystal structure of recombinant plasmepsin II complexed with pepstatin A was determined. This represents the first reported crystal structure of a protein from P. falciparum. The crystals contain molecules in 2 different conformations, revealing a remarkable degree of interdomain flexibility of the enzyme. The structure was used to design a series of selective low MW compounds that inhibit both plasmepsin II and the growth of P. falciparum in culture. KW - antimalarials KW - biochemistry KW - crystallography KW - drug development KW - enzymes KW - inhibition KW - malaria KW - parasites KW - proteinases KW - structure KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - aspartic proteases KW - pepstatin A KW - plasmepsin I KW - plasmepsin II KW - plasmepsins KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805680&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. AU - Moss, B. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 21 SP - 11341 EP - 11348 SN - 0027-8424 AD - Moss, B.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0445, USA. N1 - Accession Number: 19960106532. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 180 ref. Subject Subsets: Veterinary Science; Agricultural Biotechnology N2 - The use of vaccinia virus as a vector for expressing genes within the cytoplasm of mammalian cells is reviewed. Recombinant vaccinia viruses are used to synthesize and analyse the structure-function relationship of proteins, determine the targets of humoral and cell-mediated immunity, and investigate the types of immune response needed for protection against specific infectious diseases and cancer. The vaccine potential of recombinant vaccinia virus has been realized in the form of an effective oral wild-life rabies vaccine, although no product for humans has been licensed. A genetically altered vaccinia virus that is unable to replicate in mammalian cells and produces diminished cytopathic effects retains the capacity for high-level gene expression and immunogenicity while promising exceptional safety for laboratory workers and potential vaccine recipients. KW - biotechnology KW - gene expression KW - recombinant vaccines KW - reviews KW - safety KW - vaccination KW - vectors KW - vaccinia virus KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960106532&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of circumsporozoite proteins from avian and mammalian malarias: biological and phylogenetic implications. AU - McCutchan, T. F. AU - Kissinger, J. C. AU - Touray, M. G. AU - Rogers, M. J. AU - Li Jun AU - Sullivan, M. AU - Braga, E. M. AU - Krettli, A. U. AU - Miller, L. H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 21 SP - 11889 EP - 11894 SN - 0027-8424 AD - McCutchan, T. F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970800371. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Circumsporozoite (CS) protein genes have been characterized from many Plasmodium that infect mammals: 2 domains of the corresponding proteins, identified initially by their conservation (region I and region II), have been implicated in binding to hepatocytes. The CS gene from the avian parasite Plasmodium gallinaceum was characterized to compare these functional domains to those of mammalian Plasmodium and for the study of Plasmodium evolution. The P. gallinaceum protein showed the characteristics of CS proteins, including a secretory signal sequence, central repeat region, regions of charged amino acids and an anchor sequence. Comparison with CS signal sequences revealed 4 distinct groupings, with P. gallinaceum most closely related to the human P. falciparum. The 5-amino acid sequence designated region I, which is identical in all mammalian CS and implicated in hepatocyte invasion, was different in P. gallinaceum where the repeat region consists of 9-amino acid repeats with the consensus sequence QP(A/V)GGNGG(A/V). The conserved motif designated region II-plus, which is associated with targeting the invasion of liver cells, was also conserved in P. gallinaceum. Phylogenetic analysis of the aligned Plasmodium CS sequences yielded a tree with a topology similar to the one obtained using sequence data from the small subunit rRNA gene. The phylogeny using the CS gene supports the proposal that P. falciparum is significantly more related to avian Plasmodium than to other Plasmodium infecting mammals, although the biology of sporozoite invasion is different between the avian and mammalian species. KW - amino acid sequences KW - characterization KW - circumsporozoite protein KW - evolution KW - genes KW - liver cells KW - molecular genetics KW - nucleotide sequences KW - parasites KW - phylogeny KW - proteins KW - sporozoites KW - surface proteins KW - birds KW - mammals KW - Plasmodium KW - Plasmodium falciparum KW - Plasmodium gallinaceum KW - protozoa KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium KW - biochemical genetics KW - DNA sequences KW - hepatocytes KW - membrane proteins KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800371&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. AU - Zheng, R. AU - Jenkins, T. M. AU - Craigie, R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 24 SP - 13659 EP - 13664 SN - 0027-8424 AD - Zheng, R.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0560, USA. N1 - Accession Number: 19972004868. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 7440-66-6. N2 - Studies of the binding of zinc to HIV-1 integrase protein showed that it bound zinc with a stoichiometry of 1 zinc per integrase monomer. Analysis of zinc binding to deletion derivatives of integrase located the binding site to the N-terminal domain. Integrase with a mutation in the pair of His and Cys residues (HHCC motif) did not bind zinc, consistent with coordination of zinc by these residues. The isolated N-terminal domain was disordered in the absence of zinc but, in the presence of zinc, it adopted a secondary structure with a high alpha helical content. Integrase bound by zinc tetramerized more readily than the apoenzyme and was also more active than the apoenzyme in in vitro integration assays. It is concluded that binding of zinc to the HHCC motif stabilizes the folded state of the N-terminal domain of integrase and bound zinc is required for optimal enzymatic activity. KW - catalytic activity KW - derivatives KW - enzymes KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - mutations KW - residues KW - structure KW - zinc KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004868&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines. AU - Kinter, A. L. AU - Ostrowski, M. AU - Goletti, D. AU - Oliva, A. AU - Weissman, D. AU - Gantt, K. AU - Hardy, E. AU - Jackson, R. AU - Ehler, L. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 24 SP - 14076 EP - 14081 SN - 0027-8424 AD - Kinter, A. L.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19972004866. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 308079-78-9. N2 - This study demonstrates that the β-chemokines macrophage inflammatory proteins 1α and 1β (MIP-1α and MIP-1β) and RANTES (regulated on activation, normally T-cell expressed and secreted) inhibit HIV replication in anti-CD3 or recall antigen-stimulated peripheral blood mononuclear cells (PBMC) of asymptomatic HIV-infected subjects. Significant levels of β-chemokines were produced by both CD4+ and CD8+ PBMC subsets from HIV-infected individuals. Neutralization of endogenous MIP-1α, MIP-1β and RANTES did not rescue HIV replication in cultures to which >10% CD8+ T cells had been added, indicating that the HIV suppressor activity of CD8+ T cells cannot be explained entirely by the β-chemokines. However, significant enhancement of viral replication was observed upon neutralization of endogenous β-chemokines in CD8-depleted or CD4+ PBMCs from most donors, particularly in cultures with low inducible levels of HIV production. In contrast, certain endogenous proinflammatory cytokines induced HIV replication in these same cells. It is suggested that the levels of HIV replication in CD4+ PBMC reflect the balance of the opposing effects of endogenous suppressive factors, such as the β-chemokines, and HIV-inducing cytokines, such as tumour necrosis factor-α and interleukin 1β. KW - asymptomatic infections KW - chemokines KW - cytokines KW - effects KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - interleukins KW - macrophages KW - neutralization KW - proteins KW - regulation KW - replication KW - t lymphocytes KW - tumour necrosis factor KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cachectin KW - cachexin KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004866&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transduction of nondividing cells using pseudotyped defective high-titre HIV type 1 particles. AU - Reiser, J. AU - Harmison, G. AU - Kluepfel-Stahl, S. AU - Brady, R. O. AU - Karlsson, S. AU - Schubert, M. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 26 SP - 15266 EP - 15271 SN - 0027-8424 AD - Reiser, J.: Molecular and Medical Genetics Section, Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001394. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - Pseudotyped HIV-1 particles carrying either the ecotropic or amphotropic Moloney murine leukaemia virus (Mo-MLV) envelope proteins or the vesicular stomatitis virus G protein were released after single or double transfections of either human 293T or monkey COS-7 cells with titres of up to 107 colony-forming units/ml. A simple ultrafiltration procedure resulted in an additional 10 to 20-fold concentration of the pseudotyped particles. These vectors along with Mo-MLV-based vectors were used to transduce primary human skin fibroblasts and human peripheral blood CD34+ cells. The HIV-1 vector system was significantly more efficient than its Mo-MLV-based counterpart in transducing human skin fibroblasts arrested at the G0/G1 stage of the cell cycle by density-dependent inhibition of growth. Human CD34+ cells were transduced efficiently using HIV-1 pseudotype particles without prior stimulation with cytokines. KW - disease vectors KW - envelope proteins KW - fibroblasts KW - gene therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - proteins KW - stimulation KW - treatment KW - vectors KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD8+ T-cell-derived soluble factor(s), but not β-chemokines RANTES, MIP-1α, and MIP-1β, suppress HIV-1 replication in monocyte/macrophages. AU - Moriuchi, H. AU - Moriuchi, M. AU - Combadiere, C. AU - Murphy, P. M. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1996/// VL - 93 IS - 26 SP - 15341 EP - 15345 SN - 0027-8424 AD - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001397. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9008-11-1. N2 - To investigate whether a CD8+ T-cell-derived soluble factor(s) can also suppress HIV infection in the monocyte/macrophage (M/M) system, primary macrophages were infected with the macrophage tropic HIV-1 strain Ba-L. CD8+ T-cell-depleted peripheral blood mononuclear cells were also infected with HIV-1 IIIB or Ba-L. HIV expression from the chronically infected macrophage cell line U1 was also determined in the presence of CD8+ T-cell supernatants or β-chemokines. It is demonstrated that: CD8+ T-cell supernatants did, but β-chemokines did not, suppress HIV replication in the M/M system; antibodies to RANTES (regulated on activation normal T-cell expressed and secreted), macrophage inflammatory protein 1α (MIP-1α) and MIP-1β did not, whereas antibodies to interleukin-10, interleukin-13, interferon-α or interferon-γ modestly reduced anti-HIV activity of the CD8+ T-cell supernatants; and the CD8+ T-cell supernatants did, but β-chemokines did not, suppress HIV-1 IIIB replication in peripheral blood mononuclear cells as well as HIV expression in U1 cells. It is suggested that HIV-suppressor activity of CD8+ T cells is a multifactorial phenomenon, and that RANTES, MIP-1α and MIP-1β do not account for the entire scope of CD8+ T-cell-derived HIV-suppressor factors. KW - antibodies KW - antigens KW - cd8 antigens KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - interferon KW - macrophages KW - replication KW - t lymphocytes KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - antigenicity KW - CD8 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunogens KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001397&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12. AU - Blauvelt, A. AU - Chougnet, C. AU - Shearer, G. M. AU - Katz, S. I. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1996/// VL - 97 IS - 6 SP - 1550 EP - 1555 SN - 0021-9738 AD - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19962006259. Publication Type: Journal Article. Language: English. Number of References: 64 ref. KW - cytokines KW - dendritic cells KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - interleukins KW - T lymphocytes KW - twins KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Langerhans cells KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006259&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pain in pediatric human immunodeficiency virus infection: incidence and characteristics in a single-institution pilot study. AU - Hirschfeld, S. AU - Moss, H. AU - Dragisic, K. AU - Smith, W. AU - Pizzo, P. A. JO - Pediatrics JF - Pediatrics Y1 - 1996/// VL - 98 IS - 3 SP - 449 EP - 452 SN - 0031-4005 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. N1 - Accession Number: 19982002082. Publication Type: Journal Article; Annual report; Journal article. Language: English. N2 - Children with human immunodeficiency virus (HIV) infection have multiple complications associated with the disease process. Many of these complications are potentially painful and could affect the patient's quality of life. We examined the incidence and characteristics of the perception of pain in a cohort of families with children with HIV infection. A questionnaire was developed and validated with a cohort of families with children with cancer. In a survey of families at the Pediatric Branch of the National Cancer Institute, 61 children with HIV infection and their care givers, along with 19 children with cancer and their care givers, were interviewed to determine the incidence and impact of pain. Fifty-nine percent of the HIV-infected children and 55% of their care givers described pain as a component of their illness that impacted on their lives. Younger children and girls tended to report more pain. There was also a tendency for biological parents to expect and to treat more pain than foster parents, although there was no difference in the incidence of pain that biological and foster parents reported for their children. No differences were found between parents who were HIV positive and those who were not. In addition, no correlations were noted in incidence, expectation, or impact of pain with disease progression or surrogate markers such as CD4 counts. Pain in HIV-infected patients tended to be either in the gastrointestinal tract or limbs and usually responded to nonsteroidal anti-inflammatory therapy. The patients with cancer reported an incidence (47%) and impact of pain similar to those of previously reported studies on pediatric patients with cancer. Pain is common among children infected with HIV and can adversely impact on their lives, and its management should be a component of the general care of these patients. KW - CD4 antigens KW - children KW - complications KW - digestive system KW - digestive tract KW - disease course KW - families KW - girls KW - HIV infections KW - human immunodeficiency viruses KW - illness KW - infection KW - management KW - neoplasms KW - patients KW - questionnaires KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - alimentary tract KW - cancers KW - care providers KW - CD4 KW - disease progression KW - gastrointestinal system KW - gastrointestinal tract KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - perceptions KW - Health Services (UU350) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002082&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression. AU - Štefanová, I. AU - Saville, M. W. AU - Peters, C. AU - Cleghorn, F. R. AU - Schwartz, D. AU - Venzon, D. J. AU - Weinhold, K. J. AU - Jack, N. AU - Bartholomew, C. AU - Blattner, W. A. AU - Yarchoan, R. AU - Bolen, J. B. AU - Horak, I. D. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1996/// VL - 98 IS - 6 SP - 1290 EP - 1297 SN - 0021-9738 AD - Štefanová, I.: Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001029. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - In order to elucidate the mechanism of the HIV infection induced T cell unresponsiveness, signal-transducing molecules proximal to the T cell receptor (TCR) were studied in T lymphocytes of HIV-infected individuals. Total amounts of protein tyrosine kinases (PTKs) Lck, Fyn and ZAP-70 and the ζ chain of the TCR were found significantly decreased in T cells of symptomatic/AIDS patients as well as in T cells of individuals in acute and early asymptomatic stages of HIV infection. Unexpectedly, the detection of Lck, Fyn and ZAP-70 was reversed after the treatment of cell lysates with dithiothreitol. It is suggested that PTKs Lck, Fyn and ZAP-70 are modified by a mechanism altering the status of sulfhydryl groups. Moreover, this mechanism seemed to affect selectively T cells of HIV infected patients since B cell PTKs Syk and Lyn were detected structurally and functionally intact. Similar alterations of signalling molecules were not detected in T cells of HIV-infected long-term asymptomatic individuals. It is suggested that modification of T cell PTKs may therefore underlie the HIV-induced impairment of lymphocyte function and may potentially predict disease progression. KW - acquired immune deficiency syndrome KW - disease course KW - enzymes KW - human diseases KW - human immunodeficiency viruses KW - receptors KW - signal transduction KW - t lymphocytes KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - disease progression KW - human immunodeficiency virus KW - protein tyrosine kinases KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001029&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fungal infections. A growing threat. AU - Dixon, D. M. AU - McNeil, M. M. AU - Cohen, M. L. AU - Gellin, B. G. AU - Montagne, J. R. la JO - Public Health Reports JF - Public Health Reports Y1 - 1996/// VL - 111 IS - 3 SP - 226 EP - 235 SN - 0033-3549 AD - Dixon, D. M.: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19961201440. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The emergence of newly identified fungal pathogens and the re-emergence of previously uncommon fungal diseases in immunocompromised patients are reviewed. Infections due to Pneumocystis carinii, Candida, Cryptococcus neoformans, Trichosporon, Malassezia, Aspergillus, Penicillium marneffei, Coccidioides immitis, Histoplasma capsulatum, Blastomyces dermatitidis and Sporothrix schenckii are considered. The prevention and control of these mycoses is discussed, including increased surveillance, availability of rapid, non-invasive diagnostic tests and monitoring the development of resistance to antifungal agents. KW - aspergillosis KW - blastomycosis KW - candidosis KW - coccidioidomycosis KW - control KW - cryptococcosis KW - diagnosis KW - drug resistance KW - drug therapy KW - histoplasmosis KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - infections KW - mycoses KW - opportunistic infections KW - pneumocystosis KW - predisposition KW - reviews KW - sporotrichosis KW - Aspergillus KW - Blastomyces dermatitidis KW - Candida KW - Coccidioides immitis KW - Cryptococcus neoformans KW - Histoplasma capsulatum KW - Malassezia KW - man KW - Penicillium marneffei KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Sporothrix schenckii KW - Trichosporon KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Blastomyces KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Malasseziales KW - Ustilaginomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Penicillium KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Sporothrix KW - Ophiostomataceae KW - Ophiostomatales KW - Sordariomycetes KW - Trichosporonaceae KW - Ajellomyces capsulatus KW - candidiasis KW - chemotherapy KW - coccidiomycosis KW - european blastomycosis KW - fungus KW - Hyphomycetes KW - penicilliosis KW - trichosporonosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201440&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inclusion body myositis in HIV-1 and HTLV-1 infected patients. AU - Cupler, E. J. AU - Leon-Monzon, M. AU - Miller, J. AU - Semino-Mora, C. AU - Anderson, T. L. AU - Dalakas, M. C. JO - Brain JF - Brain Y1 - 1996/// VL - 119 SP - 1887 EP - 1893 AD - Cupler, E. J.: The Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, Building 10, Rm 4N248, MSC 1382, Bethesda, MD 20892-1382, USA. N1 - Accession Number: 19972002850. Publication Type: Journal Article. Language: English. Number of References: 26 ref. N2 - Three retrovirally infected patients are described, two with HIV-1 and one with HTLV-I, with clinical, immunopathological and histological features identical to sporadic inclusion body myositis occurring in non-infected patients. KW - body parts KW - case reports KW - clinical aspects KW - histology KW - human diseases KW - human immunodeficiency viruses KW - musculoskeletal system KW - pathology KW - USA KW - Deltaretrovirus KW - Human immunodeficiency virus 1 KW - human T-cell lymphotropic virus type I KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - skeletomuscular system KW - sporadic infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002850&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Advances in the management of AIDS-related cytomegalovirus retinitis. AU - Masur, H. AU - Whitcup, S. M. AU - Cartwright, C. AU - Polis, M. AU - Nussenblatt, R. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1996/// VL - 125 IS - 2 SP - 126 EP - 136 SN - 0003-4819 AD - Masur, H.: Clinical Center of the National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962007270. Publication Type: Journal Article. Language: English. Number of References: 69 ref. KW - acquired immune deficiency syndrome KW - clinical aspects KW - drug therapy KW - eye diseases KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - medical treatment KW - prophylaxis KW - retinitis KW - reviews KW - cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation between sodium balance and menstrual cycle symptoms in normal women. AU - Olson, B. R. AU - Forman, M. R. AU - Lanza, E. AU - McAdam, P. A. AU - Beecher, G. AU - Kimzey, L. M. AU - Campbell, W. S. AU - Raymond, E. G. AU - Brentzel, S. L. AU - Guttsches-Ebeling, B. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1996/// VL - 125 IS - 7 SP - 564 EP - 567 SN - 0003-4819 AD - Olson, B. R.: National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19971402940. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9015-94-5, 7440-23-5. Subject Subsets: Human Nutrition N2 - A prospective study of menstrual symptoms during 3 cycles: a baseline month (usual intake of sodium 115 mmol/day) followed by 2 months of Na restriction (Na intake 73.0 mmol/day) was undertaken in 13 healthy menstruating women (21-35 years old). Added salt was allowed during the last month. Investigators were aware of the diet sequence. Meals were prepared in a metabolic kitchen during the 2 months that the participants received salt-restricted diets. Plasma Na levels, urinary Na excretion and plasma renin activity were measured for 5 time periods during the baseline cycle and the 2 cycles of salt-restricted diet. 11 women completed a questionnaire assessing somatic symptoms and sensory cravings at the same time every day during the 3-month study period. Na restriction was associated with a mean decrease in plasma Na levels of 0.9±0.9 mmol/litre from a mean of 139.3 mmol/litre during the baseline cycle (P=0.018), a decrease in urinary Na excretion of 40.3±18 mmol/day from a mean of 117 mmol/day during the baseline cycle (P=0.001) and an increase in plasma renin activity of 0.14±0.08 ng/(litre/s) from a mean of 0.28 ng/(litre/s) during the baseline cycle (P=0.008). During the luteal phase of the Na restriction cycle, significant decreases in plasma Na levels of 1.23±0.5 mmol/litre (from values of 138.8 mmol/litre during the follicular phase) and increases in urinary Na excretion of 27.2±10 mmol/day (from values of 65.5 mmol/day during the follicular phase) preceded periods when menstrual symptoms were most severe. Ratings of breast tenderness increased 6- to 8-fold in the late luteal phase (P<0.001) and those of swelling or bloating increased 2- to 3-fold during early menses (P<0.001) compared with nadir symptom ratings during each cycle. Na cravings increased in the luteal phase of all cycles but were not accompanied by increased Na intake when access to added salt was allowed. Breast tenderness and bloating did not result from sodium retention in the luteal phase of the menstrual cycle. During normal and Na-restricted diet cycles, women actually had urinary Na loss, not retention, during the luteal phase; severity of menstrual symptoms was unchanged. KW - activity KW - blood KW - deprivation KW - excretion KW - intake KW - menstrual cycle KW - menstruation KW - minerals KW - renin KW - salt KW - sodium KW - symptoms KW - urine KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human Reproduction and Development (VV060) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402940&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analytical instruments for stable isotopic tracers in mineral metabolism. AU - Yergey, A. L. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 1 SP - 355S EP - 361S SN - 0022-3166 AD - Yergey, A. L.: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19961402398. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-95-4, 7440-66-6. Subject Subsets: Human Nutrition N2 - Thermal ionization mass spectrometry (TIMS) is the best of 4 currently used techniques for obtaining results of high accuracy and precision in studies of metal metabolism. TIMS is also the most general technique because it allows measurements of all the metallic elements of interest. The highest absolute sensitivity as well as the ability to determine multiple elements are simultaneously obtained with inductively coupled plasma mass spectrometry (ICP-MS). Current results with this technique show that, although element quantification may be done with acceptable accuracy and precision, use of ICP-MS in metabolic studies at low levels of isotopic labels may be limited. The most favourable elements for study using ICP-MS in metabolic studies appear to be magnesium, zinc and possibly iron. Use of this technique is limited further by isobaric interferences from plasma jet ion molecule reactions, and metabolic studies of calcium are particularly limited. Acceptable levels of accuracy and precision have been obtained from fast atom bombardment-secondary ion mass spectrometry (FAB-SIMS), which has allowed these approaches to be used in metabolic studies of Zn, Fe and Ca, but the approaches are ultimately limited by hydride isobaric interferences. FAB-SIMS and gas chromatography-mass spectrometry of metal chelates have the advantages of using widely available instrumentation. GC-MS of metal chelates has been shown to be useful in studies of chromium and selenium metabolism and for the determination of a number of other metals. Values of accuracy and precision from use of this approach have been satisfactory. KW - analytical methods KW - calcium KW - iron KW - magnesium KW - metabolism KW - mineral metabolism KW - trace elements KW - tracer techniques KW - zinc KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - microelements KW - Techniques and Methodology (ZZ900) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402398&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Homocysteine and neural tube defects. AU - Mills, J. L. AU - Scott, J. M. AU - Kirke, P. N. AU - McPartlin, J. M. AU - Conley, M. R. AU - Weir, D. G. AU - Molloy, A. M. AU - Lee, Y. J. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 3 SP - 756S EP - 760S SN - 0022-3166 AD - Mills, J. L.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20893, USA. N1 - Accession Number: 19961404260. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 59-30-3, 6027-13-0. Subject Subsets: Human Nutrition N2 - Homocysteine and neural tube defects (NTD) are reviewed under the headings: Is folate deficiency the cause of NTDs?; Is abnormal folate absorption the cause of NTDs?; Is a metabolic abnormality the cause of NTDs?; Is vitamin B12 a factor in NTDs?; Homocysteine levels in affected pregnancies; Animal studies of homocysteine metabolism in NTDs; and Other data suggesting that homocysteine metabolism is important. KW - congenital abnormalities KW - folic acid KW - homocysteine KW - nervous system diseases KW - pregnancy KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - birth defects KW - congenital malformations KW - folacin KW - folate KW - gestation KW - neuropathy KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404260&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary intake of fat, fiber and other nutrients is related to the use of vitamin and mineral supplements in the United States: the 1992 National Health Interview Survey. AU - Slesinski, M. J. AU - Subar, A. F. AU - Kahle, L. L. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 12 SP - 3001 EP - 3008 SN - 0022-3166 AD - Slesinski, M. J.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971403658. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 68-26-8, 1406-18-4, 50-81-7, 7440-70-2. Subject Subsets: Human Nutrition N2 - Nutrient intake from a food frequency questionnaire, demographic characteristics and lifestyle were examined in 11 643 dietary supplement users and non-users who participated in the 1992 National Health Interview Survey Epidemiology Supplement, USA. 46% reported taking a supplement in the past year, while 24% reported daily use. Daily use was highest among women, whites, people ≥75 years old, those at or above the poverty level, those with more than 12 years of education, former smokers and light drinkers consuming <1 alcoholic beverage per week. When sociodemographic factors, smoking status and drinking habits were controlled for, there were no significant differences in dietary nutrient intake between daily and occasional supplement users. Compared with those of non-users, diets of vitamin supplement users were lower (P<0.001) in fat and higher in fibre and vitamins A and C for men and women and higher in vitamin E and calcium for women only. It was concluded that the diet and the demographic and lifestyle characteristics of supplement users are typical of patterns associated with low risk of chronic disease. KW - age KW - alcoholic beverages KW - ascorbic acid KW - calcium KW - consumption KW - diet KW - diet studies KW - education KW - ethnicity KW - fat KW - fibre KW - health KW - intake KW - lifestyle KW - men KW - mineral supplements KW - minerals KW - mortality KW - neoplasms KW - nutrients KW - retinol KW - sex differences KW - socioeconomic status KW - tobacco smoking KW - vitamin e KW - vitamin supplements KW - vitamins KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - death rate KW - ethnic differences KW - fiber KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403658&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overview of perinatal HIV infection. AU - Fowler, M. G. AU - Rogers, M. F. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 10SUPPL SP - 2602S EP - 2607S SN - 0022-3166 AD - Fowler, M. G.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. N1 - Accession Number: 19971400212. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - An overview of the epidemiology of perinatal human immunodeficiency virus infection internationally is given, summarizing research on risk factors for mother-to-infant transmission. Perinatal prevention strategies being planned in developing and developed countries are discussed. KW - breast feeding KW - epidemiology KW - human immunodeficiency viruses KW - infants KW - infection KW - mothers KW - parturition KW - pregnancy KW - prevention KW - reviews KW - risk factors KW - transmammary transmission KW - transmission KW - transplacental transmission KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gestation KW - human immunodeficiency virus KW - Nutrition in pediatric HIV infection:setting the research agenda KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dysregulation of growth and development in HIV-infected children. AU - Hirschfeld, S. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 10SUPPL SP - 2641S EP - 2650S SN - 0022-3166 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971400242. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 25 ref. Registry Number: 61912-98-9, 9002-72-6, 9034-48-4. Subject Subsets: Human Nutrition N2 - Data from studies on growth stunting in infants and children infected with the human immunodeficiency virus and interactions between HIV and factors involved in the cellular regulation of growth are reviewed. KW - children KW - development KW - dysregulation KW - growth KW - growth retardation KW - human immunodeficiency viruses KW - infants KW - insulin-like growth factor KW - lymphocytes KW - metabolism KW - reviews KW - somatotropin KW - thyrotropin KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - growth hormone KW - human immunodeficiency virus KW - Nutrition in pediatric HIV infection:setting the research agenda KW - somatomedin C KW - thyroid-stimulating hormone KW - thyrotropic hormone KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400242&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neurobehavioral manifestations of symptomatic HIV-1 disease in children: can nutritional factors play a role? AU - Brouwers, P. AU - Decarli, C. AU - Heyes, M. P. AU - Moss, H. A. AU - Wolters, P. L. AU - Tudor-Williams, G. AU - Civitello, L. A. AU - Pizzo, P. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 10SUPPL SP - 2651S EP - 2662S SN - 0022-3166 AD - Brouwers, P.: Pediatric Branch, National Cancer Institute, NIH Clinical Cancer, Room 13N240, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19971400210. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 65 ref. Registry Number: 16887-00-6, 68-19-9, 59-30-3, 65-23-6, 30516-87-1. Subject Subsets: Human Nutrition N2 - This paper reviews studies investigating the influence of nutrition on the psychological function of children, in the context of human immunodeficiency virus (HIV) infection. Also the findings of a study by the authors are presented, which evaluated the association of change in body weight with changes in neurocognitive function, ventricular brain ratio and cerebrospinal quinolinic acid levels in HIV infected children (n=15; mean age 6.3 years) with symptomatic HIV-1 disease before and after 6 months of antiretroviral therapy with continuous intravenous infusion of zidovudine (ZVD). Significant increases in weight and neurocognitive function as well as decreases in ventricular brain ratio and cerebrospinal quinolinic acid levels were noted after therapy. Only the relation between increase in weight and decrease in ventricular brain ratio was significant (P<0.01); an increase in weight seemed to correlate with a decrease in neurocognitive function (NS). Another group of children treated at the same time with oral intermittent ZVD, but otherwise receiving the same care did not show the same magnitude of improvement in neurocognitive function. These results seem to suggest that general supportive and medical care as well as nutritional factors may only play a limited role in the neurocognitive improvements after antiretroviral therapy with continuous infusion ZVD. KW - antiviral agents KW - brain KW - cerebrospinal fluid KW - children KW - chloride KW - cognitive development KW - cyanocobalamin KW - deficiency KW - drug therapy KW - encephalopathy KW - folic acid KW - human immunodeficiency viruses KW - infection KW - malnutrition KW - neurochemistry KW - protein energy malnutrition KW - psychology KW - pyridoxine KW - trace elements KW - vitamin b12 KW - vitamins KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - cerebrum KW - chemotherapy KW - cobalamin KW - folacin KW - folate KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - mental development KW - microelements KW - Nutrition in pediatric HIV infection:setting the research agenda KW - protein calorie malnutrition KW - psychological factors KW - Physiology of Human Nutrition (VV120) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971400210&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intakes of minerals from diets and foods: is there a need for concern? AU - Pennington, J. A. T. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1996/// VL - 126 IS - 9SUPPL SP - 2304S EP - 2308S SN - 0022-3166 AD - Pennington, J. A. T.: Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda MD 20892-6600, USA. N1 - Accession Number: 19961410081. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 15 ref. Registry Number: 7440-70-2, 7440-50-8, 7553-56-2, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6. Subject Subsets: Human Nutrition N2 - This paper reviews results of the Total Diet Study, a yearly programme of the Food and Drug Administration in the USA, which as part of its monitoring of food supply, identifies changes and trends in the mineral content of foods and estimates daily mineral intakes. Results of the Total Diet Study are compared with results from other studies and it is concluded that there is a need for concern about intakes of calcium, magnesium, iron, zinc and copper for some age-sex categories in the USA. KW - calcium KW - copper KW - diet studies KW - iodine KW - iron KW - magnesium KW - manganese KW - minerals KW - nutrient requirements KW - phosphorus KW - potassium KW - salt KW - selenium KW - sodium KW - trace elements KW - zinc KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - dietary standards KW - food requirements KW - microelements KW - Mn KW - New approaches, endpoints and paradigms for RDAs of mineral elements KW - nutritional requirements KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410081&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Natural history of somatic growth in infants born to women infected by human immunodeficiency virus. AU - Moye, J., Jr. AU - Rich, K. C. AU - Kalish, L. A. AU - Sheon, A. R. AU - Diaz, C. AU - Cooper, E. R. AU - Pitt, J. AU - Handelsman, E. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1996/// VL - 128 IS - 1 SP - 58 EP - 69 SN - 0022-3476 AD - Moye, J., Jr.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 19962003776. Publication Type: Journal Article. Corporate Author: USA, Women and Infants Transmission Study Group Language: English. KW - acquired immune deficiency syndrome KW - anthropometric dimensions KW - growth KW - growth factors KW - height KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - natural history KW - weight KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - anthropometric measurements KW - head dimensions (agricola) KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - maternal KW - women transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003776&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thyroid abnormalities in children infected with human immunodeficiency virus. AU - Hirschfeld, S. AU - Laue, L. AU - Cutler, G. B., Jr. AU - Pizzo, P. A. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1996/// VL - 128 IS - 1 SP - 70 EP - 74 SN - 0022-3476 AD - Hirschfeld, S.: Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19962003777. Publication Type: Journal Article. Language: English. Registry Number: 51-48-9, 55-06-1, 6893-02-3. KW - abnormalities KW - acquired immune deficiency syndrome KW - children KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - T lymphocytes KW - thyroid gland KW - thyroid hormones KW - thyroxine KW - triiodothyronine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - function KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - liothyronine KW - T cells KW - thyroid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003777&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of virus burden in blood and sequential lymph node biopsy specimens from children infected with human immunodeficiency virus. AU - Mueller, B. U. AU - Sei, S. AU - Anderson, B. AU - Luzuriaga, K. AU - Farley, M. AU - Venzon, D. J. AU - Tudor-Williams, G. AU - Schwartzentruber, D. J. AU - Fox, C. AU - Sullivan, J. L. AU - Pizzo, P. A. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1996/// VL - 129 IS - 3 SP - 410 EP - 418 SN - 0022-3476 AD - Mueller, B. U.: Pediatric Branch, National Cancer Institute, Bethesda MD 20892-1928, USA. N1 - Accession Number: 19962009319. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 129618-40-2. KW - antiviral agents KW - biopsy KW - children KW - disease course KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - lymph nodes KW - nevirapine KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009319&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of a unique VP4 serotype that is shared by a human rotavirus (69M strain) and an equine rotavirus (H-2 strain). AU - Li, B. AU - Hoshino, Y. AU - Gorziglia, M. JO - Archives of Virology JF - Archives of Virology Y1 - 1996/// VL - 141 IS - 1 SP - 155 EP - 160 SN - 0304-8608 AD - Li, B.: Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19962215624. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - A cDNA clone representing the VP4-encoding gene of human rotavirus strain 69M (VP7 serotype 8) was constructed and inserted into a baculovirus expression vector. Baculovirus recombinants that expressed the 69M VP4 protein in Spodoptera frugiperda (Sf9) cells were screened by immunofluoresence with hyperimmune antiserum to the 69M strain and purified by terminal dilution. The expressed VP4 was detected by Coomassie blue staining of PAGE-separated proteins. The antigenic relationships between the VP4 of the 69M strain and those of various human and other animal rotavirus strains representing 10 established VP4 serotypes were examined by plaque reduction neutralization. Hyperimmune antiserum produced in guineapigs following immunization with a lysate of Sf9 cells infected with a 69M gene-4-baculovirus recombinant neutralized the infectivity of the homologous human rotavirus 69M strain as well as heterologous equine rotavirus H-2 strain to a high titre. The anti-69M VP4 hyperimmune antiserum did not neutralize other rotavirus strains of human, simian, porcine, bovine, or murine origin. It is concluded that the human rotavirus 69M strain has a distinct VP4 serotype (designated as P serotype 4) which is closely related antigenically to equine rotavirus H-2 VP4. KW - antigenic variation KW - gene expression KW - horse diseases KW - immune serum KW - infectivity KW - recombination KW - serotypes KW - viral diseases KW - viral proteins KW - virus neutralization KW - horses KW - man KW - rotavirus KW - Equus KW - Equidae KW - Perissodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - antigenic polymorphism KW - antiserum KW - genetic recombination KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pets and Companion Animals (LL070) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962215624&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States. AU - Song, J. W. AU - Baek, L. J. AU - Nagle, J. W. AU - Schlitter, D. AU - Yanagihara, R. JO - Archives of Virology JF - Archives of Virology Y1 - 1996/// VL - 141 IS - 5 SP - 959 EP - 967 SN - 0304-8608 AD - Song, J. W.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19970500579. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 63231-63-0. N2 - The S and M segments of a hantavirus, enzymatically amplified from tissues of Cloudland deer mice (Peromyscus maniculatus nubiterrae) captured during 1985 in West Virginia, USA, diverged from strains of Four Corners virus from the southwestern USA by more than 16% and 6% at the nucleotide and amino acid levels, respectively. Phylogenetic analysis suggested that this virus strain (designated Monongahela) forms a possible evolutionary link between the Four Corners and New York hantaviruses. KW - amino acid sequences KW - molecular genetics KW - phylogeny KW - RNA KW - small mammals KW - viral proteins KW - wild animals KW - USA KW - West Virginia KW - Hantavirus KW - Peromyscus maniculatus KW - Bunyaviridae KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Peromyscus KW - Sigmodontinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Appalachian States of USA KW - Southern States of USA KW - USA KW - South Atlantic States of USA KW - biochemical genetics KW - Monongahela virus KW - protein sequences KW - ribonucleic acid KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500579&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of Borrelia burgdorferi genes encoding homologues of DNA-binding protein HU and ribosomal protein S20. AU - Tilly, K. AU - Fuhrman, J. AU - Campbell, J. AU - Samuels, D. S. JO - Microbiology (Reading) JF - Microbiology (Reading) Y1 - 1996/// VL - 142 IS - 9 SP - 2471 EP - 2479 SN - 1350-0872 AD - Tilly, K.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19960505771. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology N2 - Linear DNA with covalently closed ends is the predominant form of DNA in the spirochaete B. burgdorferi. All bacteria examined to date have small DNA-binding proteins related to the Escherichia coli IHF and HU proteins that appear to play roles in DNA compaction and replication, but such proteins had not been isolated from bacteria with linear genomes. The authors found a single gene in B. burgdorferi (named hbb) whose product (named Hbb) complements the defects for λ DNA packaging found in E. coli strains mutant in the genes for IHF and HU. The sequence of the predicted B. burgdorferi protein is similar to those of HU and IHF-like proteins in other bacteria. The gene appears to be in an operon with the order rpsT-hbb-orfH, where the rpsT gene is a homologue of the E. coli gene encoding ribosomal protein S20 and the orfH gene encodes a protein of unknown function. This operon is located upstream of the previously identified B. burgdorferi rho homologue. KW - amino acid sequences KW - binding proteins KW - DNA KW - genes KW - molecular genetics KW - nucleotide sequences KW - proteins KW - ribosomes KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - carrier proteins KW - deoxyribonucleic acid KW - DNA sequences KW - HU protein KW - integration host factor KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960505771&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Measurement of exposure to nutrients: an approach to the selection of informative foods. AU - Mark, S. D. AU - Thomas, D. G. AU - Decarli, A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 143 IS - 5 SP - 514 EP - 521 SN - 0002-9262 AD - Mark, S. D.: Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892-7368, USA. N1 - Accession Number: 19961407583. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition KW - diet study techniques KW - questionnaires KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Techniques and Methodology (ZZ900) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407583&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation. AU - Mark, S. D. AU - Wang Wen AU - Fraumeni, J. F., Jr. AU - Li JunYao AU - Taylor, P. R. AU - Wang GuoQing AU - Guo, W. AU - Dawsey, S. M. AU - Li Bing AU - Blot, W. J. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 143 IS - 7 SP - 658 EP - 664 SN - 0002-9262 AD - Mark, S. D.: National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961406837. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Human Nutrition N2 - 3318 men and women (40-69 years old) from a region in rural China were randomized to receive daily either a multiple vitamin/mineral supplement or a placebo. Deaths that occurred in the participants were ascertained and classified according to cause over the 6-year period from 1985 to 1991. At the end of supplementation, blood pressure readings were taken, and the prevalence of hypertension was determined. There was a slight reduction in overall mortality in the supplement group (relative risk (RR) = 0.93, 95% confidence interval (CI) 0.75-1.16), with the decreased relative risk most pronounced for cerebrovascular disease deaths (RR = 0.63, 95% CI 0.37-1.07). This benefit was greater for men (RR = 0.42, 95% CI 0.19-0.93) than for women (RR = 0.93, 95% CI 0.44-1.98). Among the survivors, the presence of elevations in both systolic and diastolic blood pressures were less common in those who received the supplement (RR for men = 0.43, 95% CI 0.28-0.65; RR for women = 0.92, 95% CI 0.68-1.24). This study indicates that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet. KW - antioxidants KW - cardiovascular diseases KW - hypertension KW - mineral supplements KW - minerals KW - stroke KW - vitamin supplements KW - vitamins KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - high blood pressure KW - People's Republic of China KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary assessment in epidemiology: comparison of a food frequency and a diet history questionnaire with a 7-day food record. AU - Jain, M. AU - Howe, G. R. AU - Rohan, T. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 143 IS - 9 SP - 953 EP - 960 SN - 0002-9262 AD - Jain, M.: National Cancer Institute of Canada (NCIC) Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Ontario, Canada. N1 - Accession Number: 19961409181. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition N2 - The validity of 2 types of diet assessment methods, a self-administered food frequency questionnaire and an interviewer-administered detailed diet history, was assessed relative to a 7-day food record on a population-based sample of 95 men and 108 women in Toronto, Canada, between May 1989 and July 1990. Each study subject completed both questionnaire methods, a food frequency questionnaire and an interviewer-administered diet history, as well as a 7-day food record in a crossover design. Data were analysed for unadjusted and energy-adjusted nutrients to estimate Pearson's and intraclass correlations and agreement within categories. Mean values for the intake of most nutrients assessed by both questionnaire methods were similar. Average, energy-adjusted Pearson's correlation coefficients for men between a food frequency questionnaire and a 7-day food record were 0.55 for macronutrients and 0.48 for micronutrients compared with 0.47 for macro- and 0.48 for micronutrients between an interviewer-administered diet history and a 7-day food record. For women, they were 0.48 for macro- and 0.54 for micronutrients between a food frequency questionnaire and a 7-day food record and 0.46 and 0.49, respectively, between an interviewer-administered diet history and a 7-day food record. The energy-adjusted Pearson correlations were generally higher than were the energy-unadjusted Pearson correlations and the intraclass correlations. The results suggest that a food frequency questionnaire is comparable with an interviewer-administered diet history as a predictor of nutrients as estimated from a 7-day food record. KW - diet study techniques KW - epidemiology KW - questionnaires KW - sex differences KW - Canada KW - Ontario KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Canada KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409181&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prospective study of relative weight and risk of breast cancer: the Breast Cancer Detection Demonstration Project follow-up study, 1979 to 1987-1989. AU - Yong LeeChen AU - Brown, C. C. AU - Schatzkin, A. AU - Schairer, C. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 143 IS - 10 SP - 985 EP - 995 SN - 0002-9262 AD - Yong LeeChen: Cancer Prevention Studies Branch, DCPC, National Cancer Institute, EPN, Room 211, 6130 Executive Blvd., MSC 7326, Rockville, MD 20852, USA. N1 - Accession Number: 19962006210. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition; Public Health N2 - The relation between adult relative weight (weight (kg)/height (m)1.5) and breast cancer risk was prospectively examined in a cohort of 54 896 women aged 31-89 years who had previously participated in the Breast Cancer Detection Demonstration Project in the USA. During a mean follow-up period of 7 years, 226 of the premenopausal women and 1198 of the postmenopausal women developed breast cancer. Analysis was performed using Cox proportional hazards regression methods with age as the underlying time variable and adjusted for the effects of potential confounders. Among postmenopausal women, the risk of breast cancer increased with increasing relative weight (P <0.05 for trend); relative risk for the highest compared with the lowest quintile for relative weight was 1.3 (95% confidence interval (CI) 1.1-1.6). This association was modified by age at diagnosis, with relative risks of 1.1 (95% CI 0.8-1.4), 1.2 (95% CI 0.8-1.7), and 1.8 (95% CI 1.3-2.5), respectively, for women aged <60, 60-64, and ≥65 years. The higher risk of breast cancer among the older and overweight women was largely confined to women whose weights were measured during the postmenopausal but not the premenopausal period. This risk pattern was observed among the naturally menopausal women, but was also apparent in the smaller group of women with bilateral oophorectomy or hysterectomy with one ovary retained. Among premenopausal women, adult relative weight was not associated with breast cancer risk. These findings suggest that the inconsistencies in the literature on obesity and breast cancer may be due in part to the differing age distributions of the populations studied. It is concluded that prevention of obesity throughout adulthood, particularly after menopause, may help reduce breast cancer among older women. KW - age differences KW - body weight KW - breast KW - breast cancer KW - neoplasms KW - obesity KW - risk factors KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - fatness KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006210&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - NHLBI Family Heart Study: objectives and design. AU - Higgins, M. AU - Province, M. AU - Heiss, G. AU - Eckfeldt, J. AU - Ellison, R. C. AU - Folsom, A. R. AU - Rao, D. C. AU - Sprafka, J. M. AU - Williams, R. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 143 IS - 12 SP - 1219 EP - 1228 SN - 0002-9262 AD - Higgins, M.: National Heart, Lung, and Blood Institute, Bethesda, MD, USA. N1 - Accession Number: 19962007119. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition N2 - The NHLBI Family Heart Study is a multicentre, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD), atherosclerosis, and cardiovascular risk factors. In phase I, 2000 randomly selected participants and 2000 with family histories of CHD were identified among 14 592 middle-aged participants in epidemiological studies in the USA. Medical histories from these individuals, their parents and their siblings were used to calculate family risk scores that compared the number of reported and validated CHD events with the number expected based on the size, sex and age of family members. A total of 657 families with the highest risk scores and early-onset CHD and 588 randomly sampled families had clinic examinations that included electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, haemostatic factors, insulin, glucose and routine chemistries. Additional biochemical and genetic studies are being performed on selected participants. Serum, plasma, lymphocytes, red cells, and DNA are stored for future studies, including genotyping of candidate genes and anonymous markers. Contributions of genes, shared and individual environments, and behaviours to variations in risk factors, preclinical atherosclerosis, and CHD will be estimated. Linkage studies, including the quantitative trait loci approach, are planned. KW - cardiovascular diseases KW - clinical examination KW - epidemiology KW - heart diseases KW - human diseases KW - risk factors KW - screening KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - coronary diseases KW - screening tests KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007119&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Benign thyroid tumors: general risk factors and their effects on radiation risk estimation. AU - Wong, F. L. AU - Ron, E. AU - Gierlowski, T. AU - Schneider, A. B. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 144 IS - 8 SP - 728 EP - 733 SN - 0002-9262 AD - Wong, F. L.: Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972000606. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health N2 - Risk factors for benign thyroid nodules and their influence on radiation effects were examined among 544 subjects who were exposed to childhood radiation treatment for benign head and neck conditions at a hospital in Chicago, Illinois, USA, during 1939-1962. In follow-up through 1991, benign thyroid nodules were diagnosed in 131 patients. The risk of benign nodules was elevated in women (relative risk (RR) = 2.2, 95% confidence interval (CI) 1.6-3.2), Jews (RR = 1.7, 95% CI 1.1-2.5), college graduates (RR = 1.8, 95% CI 1.2-2.8), and subjects whose mother had cancer (RR = 1.7, 95% CI 1.2-2.5). There were increasing trends for risk with increasing body mass index in women and decreasing height in men. Risk was increased for women who never married (RR = 3.7, 95% CI 1.6-7.3) or who never had a full-term pregnancy (RR = 2.0, 95% CI 1.1-3.3). A significant radiation dose-response relationship was observed that was not modified by sex, education, Jewish religion, or reproductive factors. The data suggest that there are genetic, life-style (including ascertainment), and hormonal factors associated with the development of benign thyroid nodules. KW - benign course KW - epidemiology KW - human diseases KW - incidence KW - neoplasms KW - radiation KW - risk factors KW - thyroid gland KW - Illinois KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - East North Central States of USA KW - cancers KW - thyroid KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000606&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Maternal smoking during pregnancy and childhood cancer. AU - Klebanoff, M. A. AU - Clemens, J. D. AU - Read, J. S. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1996/// VL - 144 IS - 11 SP - 1028 EP - 1033 SN - 0002-9262 AD - Klebanoff, M. A.: National Institute of Child Health and Human Development, National Institutes of Health, 6100 Building, Room 7B03, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19972003105. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health N2 - The association between maternal smoking during pregnancy and childhood cancer was investigated using prospectively collected data from 54 795 liveborn children in the Collaborative Perinatal Project (1959-1966) in the USA. Cases of cancer had a histological diagnosis and/or a compatible clinical course. There were 51 children with cancer, for a cumulative incidence of cancer of 1.1 per 1000 by 96 months of age. Maternal smoking was determined at each prenatal visit; 52% of mothers reported smoking at 1 or more visits. By age 8 years, cancer had occurred in 1.4 per 1000 children whose mothers did not smoke during pregnancy, compared with 0.9 per 1000 children whose mothers smoked (P = 0.15 by log rank test); the hazard ratio was 0.67 (95% confidence interval (CI) 0.38-1.17). There was no dose-response effect of smoking compared with nonsmokers (hazard ratio for 1 to 10 cigarettes/day = 0.45, more than 10 cigarettes/day = 0.83). The hazard ratio for leukaemia among children whose mothers smoked was 0.82 (95% CI 0.31-2.11); the hazard ratio for cancers other than leukaemia was 0.60 (95% CI 0.30-1.20). Adjustment did not change the hazard ratio substantially. Although the relatively small number of cases precluded extensive study of individual types of cancer, it is concluded that maternal smoking during pregnancy is not associated with an increased risk of childhood cancer in this cohort. KW - carcinogens KW - children KW - effects KW - epidemiology KW - human diseases KW - incidence KW - leukaemia KW - mothers KW - neoplasms KW - pregnancy KW - risk factors KW - tobacco smoking KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - blood cancer KW - cancers KW - gestation KW - leucaemia KW - leukemia KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003105&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fruit and vegetable intakes of children and adolescents in the United States. AU - Krebs-Smith, S. M. AU - Cook, D. A. AU - Subar, A. F. AU - Cleveland, L. AU - Friday, J. AU - Kahle, L. L. JO - Archives of Pediatrics & Adolescent Medicine JF - Archives of Pediatrics & Adolescent Medicine Y1 - 1996/// VL - 150 IS - 1 SP - 81 EP - 86 AD - Krebs-Smith, S. M.: National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19961403448. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Potatoes N2 - To identify the ways in which fruits and vegetables are consumed by children, to provide estimates of their intakes compared with recommendations, and to estimate the percentage of children meeting those recommendations, 3 days of dietary data from respondents in the US Department of Agriculture's 1989-1991 Continuing Survey of Food Intakes by Individuals were examined. All foods reported in the survey were disaggregated into their component ingredients; all fruit and vegetable ingredients were assigned specific weights to correspond with a serving as defined by current dietary guidance materials; and the number of servings of each fruit and vegetable was tallied. A total of 3148 children and adolescents aged 2 to 18 years were studied. Percentages of fruit and vegetable servings consumed in various forms, mean number of servings consumed per day, and percentage of persons meeting various recommendations by sex/age, race/ethnicity and household income were estimated. Nearly one-quarter of all vegetables consumed by children and adolescents were french fries [potato chips]. Their intakes of all fruits and of dark green and/or deep yellow vegetables were very low compared with recommendations. Only 1 in 5 children consumed 5 or more servings of fruits and vegetables per day. Paediatricians should encourage the consumption of fruits and vegetables, especially dark green and deep yellow vegetables, by children. KW - adolescents KW - children KW - chips (French fries) KW - crisps KW - diet studies KW - fruit KW - guidelines KW - intake KW - nutrition KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - French fries KW - potato chips KW - recommendations KW - teenagers KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Crop Produce (QQ050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403448&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pollutants in breast milk. AU - Rogan, W. J. JO - Archives of Pediatrics & Adolescent Medicine JF - Archives of Pediatrics & Adolescent Medicine Y1 - 1996/// VL - 150 IS - 9 SP - 981 EP - 990 AD - Rogan, W. J.: Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. N1 - Accession Number: 19960404549. Publication Type: Journal Article. Language: English. Number of References: 102 ref. Registry Number: 72-55-9, 50-29-3, 118-74-1. Subject Subsets: Dairy Science; Human Nutrition; Agricultural Entomology; Medical & Veterinary Entomology N2 - A review is presented including: chemical agents of interest; geography; multiple congeners and mixtures; polychlorinated biphenyls and polychlorinated dibenzofurans; 2,3,7,8-tetrachlorodibenzo-p-dioxin; polychlorinated biphenyls; DDT and DDE; polybrominated biphenyls; the cyclodienes; hexachlorobenzene; risk of cancer for the child; cancer in the mother; and prevention. KW - agricultural entomology KW - congeners KW - dde KW - ddt KW - herbicides KW - hexachlorobenzene KW - human milk KW - infant feeding KW - infants KW - insecticide residues KW - insecticides KW - mothers KW - neoplasms KW - nontarget effects KW - organochlorine compounds KW - pesticide residues KW - pesticides KW - pollutants KW - polybrominated biphenyls KW - polychlorinated biphenyls KW - polychlorinated dibenzodioxins KW - polychlorinated dibenzofurans KW - residues KW - reviews KW - risk KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - breast milk KW - cancers KW - cyclodienes KW - dicophane KW - HCB KW - organic chlorine compounds KW - p,p'-dichlorodiphenyldichloroethylene KW - PCBs KW - weedicides KW - weedkillers KW - Milk and Dairy Produce (QQ010) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960404549&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toxoplasma gondii infection induces specific nonresponsiveness in lymphocytes bearing the VΒ5 chain of the mouse T cell receptor. AU - Denkers, E. Y. AU - Caspar, P. AU - Hieny, S. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 3 SP - 1089 EP - 1094 SN - 0022-1767 AD - Denkers, E. Y.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962004395. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 9008-11-1. Subject Subsets: Tropical Diseases; Protozoology N2 - The authors recently reported a superantigen activity associated with Toxoplasma gondii tachyzoites that in vitro induces preferential expansion of VΒ5+ T lymphocytes following parasite stimulation of nonimmune cells. In the experiments presented in this work, VΒ5+ lymphocyte function was examined ex vivo using mice undergoing chronic and acute infection with the avirulent parasite strain ME49 or acutely infected with the attenuated mutant ts-4. Cells bearing the TCR VΒ5 chain were found to be increased by 1.5- to 2-fold during acute infection, whereas during the chronic phase, modest decreases (~20%) in cells of the latter subset were observed. When splenocytes from chronically infected animals were stimulated in vitro with tachyzoites, the preferential expansion of VΒ5+ lymphocytes seen using cells from normal mice was not observed. Furthermore, when purified T lymphocytes were cultured with plate-bound VΒ5-specific MAb, the authors found that in contrast to normal and acutely infected animals, cells from chronically infected and ts-4-vaccinated mice were nonresponsive to TCR-induced stimulation (70% to 90% reduction relative to normal cells). In control experiments, mAb to CD3 and VΒ8 elicited normal responses in the same animals. Similarly, in contrast to normal splenocytes, cells from chronically infected mice failed to produce IFN-γ in response to anti-VΒ5 MAb. These data indicate that VΒ5+ cells are rendered nonresponsive as a result of in vivo encounter with T. gondii, and as such they provide the first demonstration of VΒ-specific anergy induced by a protozoan parasite. KW - disease models KW - experimental infections KW - immune response KW - interferon KW - laboratory animals KW - monoclonal antibodies KW - parasites KW - T lymphocytes KW - tachyzoites KW - toxoplasmosis KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004395&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis. AU - Hayashi, S. AU - Chan ChiChao AU - Gazzinelli, R. AU - Roberge, F. G. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 4 SP - 1476 EP - 1481 SN - 0022-1767 AD - Hayashi, S.: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. N1 - Accession Number: 19960803261. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 10102-43-9. Subject Subsets: Protozoology N2 - The effect of nitric oxide (NO) production on the evolution of toxoplasmosis in C57BL/6 mice was examined. Infection was induced by ip injection of Toxoplasma gondii strain ME49. NO synthesis was inhibited by treatment with aminoguanidine, a structural analogue of L-arginine. The severity of infection was evaluated by histopathologic examination of the brain. In the infected mice treated for 2 weeks with aminoguanidine, an increase in the number of Toxoplasma tachyzoites and intracellular cysts was observed accompanied by an exacerbated inflammation of the brain tissue compared with that in controls. When spleen cells from infected mice were stimulated in culture with Toxoplasma antigen, there was a marked cytotoxic effect on cells collected during the acute stage of infection and an inhibition of proliferation of the remaining viable lymphocytes. These effects were correlated with high levels of NO and PGE2 production. The suppression of NO synthesis prevented cell death and restored the lymphocyte proliferative response as well as lymphokine production. The neutralization of IFN-γ or TNF-α had no effect on NO production in the cultures of infected mouse spleen cells. Cultures in which purified macrophages and lymphocytes from infected and naive mice were mixed indicated that the production of NO was dependent on lymphocyte activation. In the later stages of infection, when the production of NO was abating, preventing PGE2 secretion with indomethacin also increased the lymphocyte proliferative response. It is concluded that the opposing effects of NO in toxoplasmosis, which protects against Toxoplasma gondii and at the same time limits the immune response, probably contribute to the establishment of the characteristic chronic state of host parasite equilibrium. KW - chronic infections KW - cytokines KW - experimental infections KW - human diseases KW - immune response KW - immunopathology KW - laboratory animals KW - nitric oxide KW - parasites KW - toxoplasmosis KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803261&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice. AU - Kullberg, M. C. AU - Berzofsky, J. A. AU - Jankovic, D. L. AU - Barbieri, S. AU - Williams, M. E. AU - Perlmann, P. AU - Sher, A. AU - Troye-Blomberg, M. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 4 SP - 1482 EP - 1489 SN - 0022-1767 AD - Kullberg, M. C.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892. N1 - Accession Number: 19960803262. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 148641-02-5, 207137-56-2. Subject Subsets: Helminthology N2 - A novel amplification mechanism underlying the increased early IL-4 production observed in Schistosoma mansoni-infected mice in response to sperm whale myoglobin (SwMb) is described. Earlier studies have shown that splenic FcεR+ non-B, non-T (NBNT) cells from schistosome-infected mice secrete IL-4 after stimulation with parasite antigen. It is demonstrated that purified NBNT cells from SwMb-immunized S. mansoni-infected mice do not respond directly to SwMb, but produce IL-4 in response to IL-3. Accordingly, it is shown that the early SwMb-specific IL-4 response of spleen cells (SC) from immunized infected mice is dependent on IL-3 and on CD4+ T cells. Thus, most of the early SwMb-induced IL-4 from SC of infected mice appears to be produced by NBNT cells triggered by IL-3 synthesized by SwMb-specific CD4+ T cells. IL-3-induced IL-4 production was also observed in purified NBNT cells from immunized uninfected mice, but the frequency and/or IL-4-producing capacity of splenic IL-3-responsive cells was found to be 8 to 16 times higher in immunized infected animals. IL-4 production by purified CD4+ cells from immunized infected mice was also seen after SwMb stimulation, but this response showed slower kinetics than those of total SC, was IL-3-independent, and on average threefold greater than that by CD4+ cells from immunized uninfected controls. Thus, increased SwMb-induced IL-4 production in immunized S. mansoni-infected mice results from direct synthesis by CD4+ T cells, as well as their stimulation via IL-3 of an expanded population of NBNT cells. The latter pathway may serve as an amplification loop for Th2-cytokine responses. KW - antigens KW - helminths KW - immune response KW - interleukin 3 KW - interleukin 4 KW - laboratory animals KW - myoglobin KW - parasites KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803262&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for distinct contributions of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant. AU - Watkins, B. A. AU - Davis, A. E. AU - Fiorentini, S. AU - MarzoVeronese, F. di AU - Reitz, M. S., Jr. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 4 SP - 1676 EP - 1683 SN - 0022-1767 AD - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, Building 37, Room 6C09, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962004338. Publication Type: Journal Article. Language: English. Number of References: 39 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - monoclonal antibodies KW - neutralization KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004338&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interference between human herpesvirus 7 and HIV-1 in mononuclear phagocytes. AU - Crowley, R. W. AU - Secchiero, P. AU - Zella, D. AU - Cara, A. AU - Gallo, R. C. AU - Lusso, P. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 5 SP - 2004 EP - 2008 SN - 0022-1767 AD - Crowley, R. W.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972000883. Publication Type: Journal Article. Language: English. Number of References: 32 ref. KW - CD4 antigens KW - HIV-1 infections KW - human diseases KW - immune response KW - inhibition KW - interactions KW - macrophages KW - monocytes KW - pathogenesis KW - receptors KW - human herpesvirus 7 KW - Human immunodeficiency virus 1 KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - CD4 KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000883&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Weight change between age 50 years and old age is associated with risk of hip fracture in white women aged 67 years and older. AU - Langlois, J. A. AU - Harris, T. AU - Looker, A. C. AU - Madans, J. JO - Archives of Internal Medicine JF - Archives of Internal Medicine Y1 - 1996/// VL - 156 IS - 9 SP - 989 EP - 994 SN - 0003-9926 AD - Langlois, J. A.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD, USA. N1 - Accession Number: 19961409651. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Human Nutrition N2 - A study was conducted to examine the effects of weight loss and weight gain from age 50 years to old age on the risk of hip fracture among 3683 postmenopausal white women aged ≥67 years and to determine if the level of weight at age 50 years modifies this risk. Extreme weight loss (≥10%) beginning at age 50 years was associated in a proportional hazards model with increased risk of hip fracture (relative risk (RR), 2.9; 95% confidence interval (CI), 2.0-4.1). This risk was greatest among women in the lowest (RR, 2.3; CI, 1.1-4.8) and middle (RR, 2.8; CI, 1.5-5.3) tertiles of body mass index at age 50 years. Among the thinnest women, even more modest weight loss (5% to <10%) was associated with increased risk of hip fracture (RR, 2.3; CI, 1.0-5.2). Weight gain of ≥10% beginning at age 50 years provided borderline protection against the risk of hip fracture (RR, 0.7; CI, 0.4-1.0). The RRs for weight gain of ≥10% were protective only among women in the middle and high tertiles of body mass index at age 50 years and were not significant (middle tertile RR, 0.8; CI, 0.3-1.8; high tertile RR, 0.6; CI, 0.2-1.9). Weight history is an important determinant of the risk of hip fracture. Weight loss beginning at age 50 years increases the risk of hip fracture in older white women, especially among those who are thin at age 50 years; weight gain of ≥10% decreases the risk of hip fracture. Physicians should include weight history in their assessment of postmenopausal older women for risk of hip fracture. KW - body weight KW - bone fractures KW - history KW - old age KW - risk KW - weight gain KW - weight reduction KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961409651&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modulation of endogenous IL-1β and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells. AU - Goletti, D. AU - Kinter, A. L. AU - Hardy, E. C. AU - Poli, G. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 156 IS - 9 SP - 3501 EP - 3508 SN - 0022-1767 AD - Goletti, D.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972005560. Publication Type: Journal Article. Language: English. Number of References: 57 ref. KW - colony stimulating factor KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunopathology KW - inhibitors KW - interleukin 1 KW - monocytes KW - pathogenesis KW - receptors KW - replication KW - synergism KW - transcription factors KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - synergy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005560&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epitope mapping by mass spectrometry. Determination of an epitope on HIV-1IIIB p26 recognized by a monoclonal antibody. AU - Parker, C. E. AU - Papac, D. I. AU - Trojak, S. K. AU - Tomer, K. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 1 SP - 198 EP - 206 SN - 0022-1767 AD - Parker, C. E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19972000895. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - Matrix-assisted laser desorption mass spectrometry in combination with proteolytic protection assays has been used to identify the functional epitope on HIV-1IIIB p26 recognized by a monoclonal antibody (mAb). In this procedure, the intact protein is affinity bound to an immobilized mAb under physiological conditions. A combination of proteolytic enzymatic cleavages was then performed to remove unprotected residues. Protected residues were identified by matrix-assisted laser desorption mass spectrometry based on their molecular weight. With this approach, an 11-residue sequence was identified as the most tightly affinity-bound fragment. In addition, two less tightly bound segments were observed. These latter two residues may contain elements of a discontinuous epitope or may be residues involved in a wider contact area. The combination of matrix-assisted laser desorption and proteolytic epitope footprinting has been applied to the determination of the epitope on a recombinant protein recognized by a mAb but should be equally applicable to the definition of an epitope on a native protein in its natural folded conformation. KW - coat proteins KW - epitopes KW - Gag protein KW - HIV-1 infections KW - human diseases KW - laboratory methods KW - mass spectrometry KW - techniques KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenic determinants KW - capsid proteins KW - human immunodeficiency virus type 1 KW - laboratory techniques KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000895&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection. AU - Frucht, D. M. AU - Holland, S. M. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 1 SP - 411 EP - 416 SN - 0022-1767 AD - Frucht, D. M.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962008191. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 9008-11-1. N2 - Six members of a family in which several members had disseminated Mycobacterium avium complex infection were studied. PHA-stimulated allogeneic cocultures of highly purified monocytes and T cells from familial patients and normal subjects, were used to show that familial patient monocytes were defective in accessory cell function for IFN-γ production. Familial patient monocytes did not inhibit IFN-γ production by normal cells, nor did inhibition of PG synthesis restore normal IFN-γ production by familial patient cells. Familial patient cells responded to the addition of exogenous IL-12 by increasing IFN-γ production, while addition of exogenous anti-IL-12 had an insignificant effect on their IFN-γ production. IL-12 was undetectable in PHA-stimulated cocultures of familial patient monocytes with familial or normal T cells. In addition, IL-12 production by adherent cells from patients and their unaffected mothers was abnormally low following stimulation with fixed Staphylococcus aureus Cowan I strain. However, normal amounts of IL-12 were detected when adherent familial patient cells were stimulated with S. aureus Cowan I strain and IFN-γ, suggesting abnormal regulation of IL-12 production by familial monocytes. It was concluded that defective IL-12 production was associated with increased susceptibility to an infectious disease, a finding that supports the critical role of this cytokine in host defence. KW - bacterial diseases KW - cytokines KW - human diseases KW - immune response KW - infections KW - interferon KW - interleukins KW - monocytes KW - susceptibility KW - man KW - Mycobacterium KW - Mycobacterium avium complex KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - bacterial infections KW - bacterioses KW - bacterium KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008191&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. AU - Gazzinelli, R. T. AU - Wysocka, M. AU - Hieny, S. AU - Scharton-Kersten, T. AU - Cheever, A. AU - Kühn, R. AU - Müller, W. AU - Trinchieri, G. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 2 SP - 798 EP - 805 SN - 0022-1767 AD - Gazzinelli, R. T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801911. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9008-11-1, 130068-27-8, 308079-78-9. Subject Subsets: Protozoology N2 - To examine the function of interleukin (IL)-10 synthesis during early infection with Toxoplasma gondii, IL-10 knockout (KO) mice were inoculated with an avirulent parasite strain (ME-49). In contrast to control mice that displayed 100% survival, the IL-10-deficient animals succumbed within the first 2 weeks of infection with no evidence of enhanced parasite proliferation. The mortality in the IL-10 KO mice was associated with enhanced liver pathology characterized by increased cellular infiltration and intense necrosis. Levels of IL-12 and interferon (IFN)-γ in sera of infected IL-10-deficient animals were 4- to 6-fold higher than those in sera from control mice, as were mRNA levels for IFN-γ, IL-1β, tumour necrosis factor (TNF)-α and IL-12 in lung tissue. Macrophages from IL-10 KO mice activated in vitro or in vivo with T. gondii produced higher levels of TNF-α and IL-12 than macrophages from controls, and spleen cells from IL-10 KO mice infected with T. gondii secreted more IFN-γ than splenocytes from nondeficient animals. In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of IFN-γ in the spleen cell populations, and in vivo depletion with anti-CD4 antibodies protected the IL-10 KO mice from parasite-induced mortality. The results suggest that endogenous IL-10 synthesis plays an important role in down-regulating monokine and IFN-γ responses to acute intracellular infection, thereby preventing host immunopathology. KW - antibodies KW - cells KW - cytokines KW - experimental infection KW - immune response KW - immunopathology KW - in vitro KW - interferon KW - interleukin 10 KW - interleukins KW - laboratory animals KW - liver KW - lungs KW - macrophages KW - mortality KW - parasites KW - pathology KW - spleen KW - strains KW - T lymphocytes KW - tumour necrosis factor KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cachectin KW - cachexin KW - death rate KW - experimental transmission KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - T cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801911&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni. AU - Jankovic, D. AU - Åslund, L. AU - Oswald, I. P. AU - Caspar, P. AU - Champion, C. AU - Pearce, E. AU - Coligan, J. E. AU - Strand, M. AU - Sher, A. AU - James, S. L. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 2 SP - 806 EP - 814 SN - 0022-1767 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801804. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - A CD4+ clone (clone B), characterized as Th1 based on its selective production of interferon (IFN)-γ and interleukin-2, was established from C57BI/6 mice protectively immunized against Schistosoma mansoni by intradermal vaccination with soluble worm antigens plus bacillus Calmette Guérin. In agreement with previous results which demonstrated an IFN-γ-dependent cell-mediated protective mechanism in this vaccination model, antigen-elicited peritoneal macrophages from syngeneic recipients of this clone were activated to kill schistosomula in vitro. Recipients of clone B also displayed significant resistance against cercarial challenge. By screening a battery of λgt11 clones from an adult worm cDNA library, one recombinant (25B) was identified that stimulated clone B specifically. Analysis of the 25B cDNA insert revealed a nucleotide sequence identical with that of the large subunit of schistosome calpain, a Ca2+-activated neutral proteinase. By expressing the products of polymerase chain reaction subcloning, a 146-amino acid region of the 25B gene was identified which contained immunological activity equivalent to the whole polypeptide. Overlapping peptides spanning this region were synthesized and a core epitope was identified with the sequence EWKGAWCDGS. Since clone B responded to supernatants from cultured schistosomula, it was postulated that the recognition of calpain released by invading larvae and the resulting induction of Th1 cytokines accounts for the protection mediated by the adoptively transferred clone. Calpain is therefore implicated as a target of protective immunity in schistosomes and provides the first example of a candidate vaccine antigen for this parasite identified on the basis of T cell reactivity. KW - amino acids KW - antigens KW - cercariae KW - clones KW - developmental stages KW - digenean larvae KW - DNA libraries KW - epitopes KW - experimental infections KW - helminths KW - immune response KW - immunization KW - in vitro KW - interferon KW - laboratory animals KW - macrophages KW - molecular genetics KW - nucleotide sequences KW - parasites KW - peptides KW - polymerase chain reaction KW - proteinases KW - recombinant vaccines KW - schistosomula KW - T lymphocytes KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - antigenic determinants KW - antigenicity KW - biochemical genetics KW - DNA sequences KW - growth phase KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - parasitic worms KW - PCR KW - proteases KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801804&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. AU - Lafrenie, R. M. AU - Wahl, L. M. AU - Epstein, J. S. AU - Hewlett, I. K. AU - Yamada, K. M. AU - Dhawan, S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 3 SP - 974 EP - 977 SN - 0022-1767 AD - Lafrenie, R. M.: Laboratory of Developmental Biology, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19962009003. Publication Type: Journal Article. Language: English. N2 - Monocytes are susceptible to HIV infection and to activation by a regulatory gene product of the HIV genome, HIV-Tat. Recently, it has been demonstrated that treatment with HIV-Tat up-regulates monocyte adhesion to the endothelium and increases metalloproteinase production. In the present study, the authors examined the ability of the HIV-Tat protein to alter the migratory and invasive behaviour of monocytes. Monocytes pretreated for 24 h with 10 ng/ml HIV-Tat exhibited enhanced migratory behaviour compared with untreated monocytes in chemotaxis assays, both in the absence of a chemoattractant as well as in response to FMLP. In addition, HIV-Tat itself induced the migration of both untreated and HIV-Tat pretreated monocytes. Checkerboard analysis showed that monocytes migrated in response to an HIV-Tat concentration gradient, thus confirming the chemotactic characteristics of the HIV-Tat protein. Pretreatment of monocytes with 10 ng/ml HIV-Tat for 24 h also increased their ability to invade reconstituted extracellular membrane (Matrigel)-coated filters by 5-fold in the absence of chemoattractant. The presence of FMLP or HIV-Tat further enhanced invasion by both untreated and HIV-Tat-pretreated monocytes by more than 10-fold. Monocyte invasion was partially inhibited by the inclusion of anti-β1 integrin Ab or tissue inhibitor of metalloproteinase (TIMP). Thus, for the first time, evidence is presented that HIV-Tat can enhance the chemotactic and invasive behaviours of monocytes and an active role is proposed for HIV-Tat in the recruitment of monocytes into extravascular tissues, a process which may contribute to the destruction of tissues and cellular architecture often seen in patients with AIDS. KW - chemotaxis KW - HIV-1 infections KW - human diseases KW - monocytes KW - pathogenesis KW - Tat protein KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009003&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine. AU - Tian JingHui AU - Miller, L. H. AU - Kaslow, D. C. AU - Ahlers, J. AU - Good, M. F. AU - Alling, D. W. AU - Berzofsky, J. A. AU - Kumar, S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 3 SP - 1176 EP - 1183 SN - 0022-1767 AD - Tian JingHui: Laboratory of Parasitic Diseases, Building 4, Room 26, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970803904. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology; Animal Breeding N2 - MSP1(19), the C-terminal 19-kDa, epidermal growth factor-like region of the merozoite surface protein 1 (MSP1), has been used as a vaccine to induce protective immunity to Plasmodium yoelii in mice and to P. falciparum in monkeys. To analyse the mechanisms and genetic regulation of this MSP1-vaccine-induced protection, the immunological correlates of protection were studied in 7 H-2 recombinant and congenic mouse strains on the B10 background. The recombinant protein was produced in Escherichia coli or Saccharomyces cerevisiae, and inoculated in 4 doses into 4 mice/group. Mice were challenged iv with 104 lethal P. yoelii 17 XL 7 days after the last dose. The number of survivors among the vaccinated mice depended on the H-2 haplotype, although the course of infection within each strain was variable; multiple H-2-linked loci were found to affect immunity, each with a different mechanism. One locus was concluded to be in the I-A region, based on the strong protection in C57BL/10 mice compared with intermediate protection in B10.A(4R) mice and the lack of a difference between B10.AKM and B10.MBR mice. Differences in efficacy of passively transferred antisera from vaccinated C57BL/10 vs B10.A(4R) mice, and in the level of immunity between vaccinated mice and those injected with sera, suggested that the protection regulated by the I-A locus was partly but not completely antibody-dependent. Two loci to the right of I-A (I-E, H-2S, or H-2D) also appeared to affect immunity, based on a correlation (P=0.03) between peak parasitaemia or mortality and the number of H-2k alleles to the right of I-A in mice that were I-Ak. One effect was antibody-independent and may correspond to a possible negative effect of the I-Ek allele. T cells from 1 nonprotected and 2 protected strains differed in their production of IFN-γ and TNF-α following immunization with MSP1(19) (the most protected strain produced less IFN-γ than the other 2, and both protected strains produced less TNF-α than the nonprotected one), but it was unclear how the differential patterns of cytokine expression related to the level of protection. It is concluded that MSP1(19)-vaccine-induced protection is regulated by H-2-linked loci corresponding to 2 different immune mechanisms. These findings may indicate the need for more than one antigen in a vaccine to protect an HLA-diverse population. KW - antibodies KW - experimental infections KW - immune response KW - immunization KW - immunogenetics KW - laboratory animals KW - major histocompatibility complex KW - malaria KW - merozoites KW - parasites KW - recombinant vaccines KW - surface proteins KW - T lymphocytes KW - vaccines KW - mice KW - Plasmodium yoelii KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - histocompatibility complex KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - membrane proteins KW - merozoite surface protein 1 KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation. AU - Goletti, D. AU - Weissman, D. AU - Jackson, R. W. AU - Graham, N. M. H. AU - Vlahov, D. AU - Klein, R. S. AU - Munsiff, S. S. AU - Ortona, L. AU - Cauda, R. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 3 SP - 1271 EP - 1278 SN - 0022-1767 AD - Goletti, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. N1 - Accession Number: 19962009004. Publication Type: Journal Article. Language: English. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - pathogenesis KW - t lymphocytes KW - Mycobacterium tuberculosis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009004&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. AU - Scharton-Kersten, T. M. AU - Wynn, T. A. AU - Denkers, E. Y. AU - Bala, S. AU - Grunvald, E. AU - Hieny, S. AU - Gazzinelli, R. T. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 9 SP - 4045 EP - 4054 SN - 0022-1767 AD - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970805445. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - The relationship between IFN-γ and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in IFN-γ knockout (gko) mice. Gko and wild type (wt) mice were inoculated with either the avirulent T. gondii strain ME49 (20 cysts per mouse) or the attenuated temperature-sensitive mutant strain ts4 (2 × 104 tachyzoites ip per mouse). The gko mice rapidly succumbed to infection with both strains of T. gondii. Microscopic examination of peritoneal exudates from infected gko mice demonstrated that mortality was associated with unchecked tachyzoite replication. However, both wt and gko mice developed a peritoneal inflammatory response that in gko mice was greater due to a 5- to 10-fold increase in the number of granulocytes recruited to the site of infection. In addition, measurement of IL-12 p40 in spleen and peritoneal cells on days 0, 3 and 5 pi, and a significant IL-12-dependent NK cell response showed that IL-12 production in gko mice was both unimpaired and functional (but lower than wt). No evidence for an IFN-γ-independent protective function for IL-12 or NK cells was apparent since in vivo treatment of gko mice with an IL-12-neutralizing mAb ablated the NK cell response, but did not decrease survival of the mice. It is concluded that there are distinct functions for IL-12 and IFN-γ in host resistance to T. gondii: IL-12 precedes and initiates synthesis of IFN-γ, while the latter lymphokine directly controls parasite growth and diminishes the contribution of IL-4 and IL-5 producing T-cell subsets. KW - acute infections KW - experimental infections KW - immune response KW - interferon KW - interleukin 12 KW - laboratory animals KW - parasites KW - tachyzoites KW - toxoplasmosis KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - cysts KW - immunity reactions KW - immunological reactions KW - severe infections KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. AU - Wynn, T. A. AU - Reynolds, A. AU - James, S. AU - Cheever, A. W. AU - Caspar, P. AU - Hieny, S. AU - Jankovic, D. AU - Strand, M. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 9 SP - 4068 EP - 4078 SN - 0022-1767 AD - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970805446. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Subject Subsets: Helminthology N2 - The effects of administering IL-12 as an adjuvant on the development of a protective humoral response in multiply immunized mice was investigated. Female C57BL/6 mice were vaccinated by immersing their tails in water containing 500 irradiated cercariae of Schistosoma mansoni for 40 min. Multiply immunized mice were vaccinated 3 times at 4- to 5-week intervals. Following percutaneous challenge with unattenuated cercariae of S. mansoni, it was found that multiply immunized mice which received IL-12 at the time of vaccination displayed a marked increase in resistance to challenge infection, with some animals demonstrating complete protection. The IL-12 vaccinated mice developed strongly polarized Th1 responses but, importantly, also showed significant increases in parasite-specific antibody and, in particular, IgG2a, IgG2b, and IgG1 isotypes. Passive transfer demonstrated an enhanced ability of serum from these animals to protect naive recipients. In addition, mice vaccinated in the presence of IL-12 also developed macrophages with increased nitric oxide-dependent killing activity against the parasites. It is concluded that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection. KW - animal models KW - experimental infections KW - helminths KW - humoral immunity KW - immune response KW - immunization KW - live vaccines KW - parasites KW - schistosomiasis KW - vaccination KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - attenuated vaccines KW - bilharzia KW - bilharziasis KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805446&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reciprocal cytotoxic T lymphocyte cross-reactivity interactions between two major epitopes within HIV-1 gp160. AU - Shirai, M. AU - Kurokohchi, K. AU - Pendleton, C. D. AU - Arichi, T. AU - Boyd, L. F. AU - Takahashi, H. AU - Margulies, D. H. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 10 SP - 4399 EP - 4411 SN - 0022-1767 AD - Shirai, M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003662. Publication Type: Journal Article. Language: English. Number of References: 51 ref. N2 - An unexpected observed cross-reactivity of CD8+ cytotoxic T lymphocytes (CTL) between 2 nonhomologous peptides of the HIV-1 IIIB gp160 envelope protein, P18 (residues 315-329) and HP53 (834-848, also called TH4.1), in the context of 4 different class I MHC molecules, Dd, Dp, Dq (or Lq) and H-2u was analysed. In strains expressing Dd, the cross-reactivity between peptides was bidirectional, whereas in other strains (H-2u, H-2p and H-2q), the cross-reactivity was unidirectional; that is, P18-specific CTLs showed no killing against targets pulsed with HP53, although HP53 stimulated CTL showed cross-reactive lysis against P18-pulsed target cells. Cross-reactivity was also shown in immunization in vivo and with target cells endogenously expressing viral protein in vitro using 2 different recombinant vaccinia viruses expressing only the N-terminal portion of gp160, containing P18 but not HP53. Peptide cross-contamination was excluded. Cold target inhibition and single cell cloning experiments indicated that the same CTL was responding to both peptides. Using substituted and truncated peptides, amino acid residues critical for cross-reactive CTL recognition were studied. Fine specificity similarities among all cross-reactive CTL lines but not non-cross-reactive lines were identified and cross-reactivity was mapped to a 10-residue core of P18 and to an 8-residue core of HP53. A comparison of these peptide sequences and recent data on residues of P18 interacting with H-2Dd provided clues to residues involved in the interaction of the CTL with the MHC-peptide complex. KW - amino acids KW - cell mediated immunity KW - cross reaction KW - cytotoxicity KW - envelope protein gp160 KW - epitopes KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - interactions KW - lymphocytes KW - peptides KW - residues KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - cellular immunity KW - gp160 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-γ with patterns of tissue expression that suggest nonredundant roles in vivo. AU - Amichay, D. AU - Gazzinelli, R. T. AU - Karupiah, G. AU - Moench, T. R. AU - Sher, A. AU - Farber, J. M. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1996/// VL - 157 IS - 10 SP - 4511 EP - 4520 SN - 0022-1767 AD - Amichay, D.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 11N-228, Bethesda, MD 20892, USA. N1 - Accession Number: 19970802357. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - MuMig and Crg-2 are interferon (IFN)-inducible murine chemokines whose human homologues (HuMig and IP-10, respectively) share activity in vitro as T cell chemoattractants. The expression of the genes Mumig, crg-2 and IFN-γ were analysed during experimental infections of mice with Plasmodium yoelii, Toxoplasma gondii and vaccinia virus. Mumig, crg-2 and IFN-γ were induced in multiple organs. During the acute phase of each infection, and after intraperitoneal injection of rIFN-γ, levels of Mumig mRNA in the liver were as high or higher than levels in any other organs. In contrast, organs showing the highest expression of crg-2 and IFN-γ varied among the experimental models, with induction of these latter 2 genes colocalizing. Differences in relative levels of expression of Mumig and crg-2 in liver and spleen were not demonstrably due to expression of the genes in different cell types within these organs. It was shown that both Mumig and crg-2 are induced in the liver in hepatocytes and in the spleen in CD11b+ cells. IFN-γ was necessary for induction of Mumig during infections with T. gondii or vaccinia virus. In contrast, induction of crg-2 was not completely dependent on IFN-γ. The results show that, despite the overlap in activities within chemokine subsets, chemokine genes show differences in their patterns of expression and in their responses to inducers that suggest nonredundant roles in vivo. The pattern of induction of crg-2 is consistent with Crg-2 acting primarily locally, whereas the pattern for Mumig induction suggests that MuMig may have a systemic role during infection. KW - cytokines KW - experimental infections KW - gene expression KW - genes KW - immune response KW - interferon KW - laboratory animals KW - liver KW - molecular genetics KW - organs KW - parasites KW - spleen KW - viral diseases KW - mice KW - Plasmodium yoelii KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - biochemical genetics KW - immunity reactions KW - immunological reactions KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cutaneous manifestations of human T cell leukemia virus type I infection in an experimental model. AU - Simpson, R. M. AU - Leno, M. AU - Hubbard, B. S. AU - Kindt, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 3 SP - 722 EP - 726 SN - 0022-1899 AD - Simpson, R. M.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. N1 - Accession Number: 19962003995. Publication Type: Journal Article. Language: English. Number of References: 16 ref. KW - disease models KW - experimental infections KW - htlv-i infections KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - rabbits KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003995&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis. AU - Mahanty, S. AU - Mollis, S. N. AU - Ravichandran, M. AU - Abrams, J. S. AU - Kumaraswami, V. AU - Jayaraman, K. AU - Ottesen, E. A. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 3 SP - 769 EP - 773 SN - 0022-1899 AD - Mahanty, S.: Clinical Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19960802804. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 130068-27-8. Subject Subsets: Helminthology; Tropical Diseases N2 - To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic microfilaraemic (MF) patients, parasite antigen (PAg)- and nonparasite antigen (NPAg)-driven IL-10 production by peripheral blood mononuclear cells (PBMC) was studied in 10 MF [Wuchereria bancrofti] patients and in 11 patients with chronic lymphatic pathology (CP). PBMC from MF patients spontaneously secreted ~10-fold more IL-10 than did PBMC from patients with CP. PAg also induced significantly more IL-10 production by PBMC from MF than from CP patients. There was a negative correlation between PAg-driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group. IL-10 secretion by plastic adherent cells from MF persons was higher in response to PAg than to NPAg, whereas IL-6 and tumour necrosis factor-α secretion were equivalent for PAg and NPAg, suggesting that PAg preferentially induces IL-10 secretion in these cells. Thus, PAg-induced IL-10 likely plays an important role in down-regulating antigen-specific proliferative responses in MF patients. KW - antigens KW - filariasis KW - helminths KW - human diseases KW - immune response KW - interleukin 10 KW - lymphatic filariasis KW - parasites KW - man KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802804&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polymerase chain reaction-based assessment after macrofilaricidal therapy in Onchocerca volvulus infection. AU - Nutman, T. B. AU - Parredes Y., W. AU - Kubofcik, J. AU - Guderian, R. H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 3 SP - 773 EP - 776 SN - 0022-1899 AD - Nutman, T. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19960802805. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Twenty-eight patients who had skin snips positive for microfilariae (Mf) were studied 120 days after receiving amocarzine, when each was negative for Mf: 16 (57%) were positive for O. volvulus DNA in a PCR-based assay. Of these, 14 (88%) were Mf positive when reassessed parasitologically on day 240, and all were Mf positive on day 365. Equally important was the finding that 12 patients had cleared both Mf and Mf DNA; only 1 was Mf positive at day 240. This suggests that the PCR-based assay provides a sensitive means for assessing infection status after macrofilaricidal chemotherapy and is an early predictor of persons likely to have a recurrence of Mf. KW - diagnosis KW - drug therapy KW - helminths KW - human diseases KW - molecular biology KW - onchocerciasis KW - parasites KW - polymerase chain reaction KW - man KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - amocarzine KW - chemotherapy KW - nematodes KW - onchocercosis KW - parasitic worms KW - PCR KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802805&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combination therapy with didanosine and interferon-α in human immunodeficiency virus-infected patients: results of a phase I/II trial. AU - Kovacs, J. A. AU - Bechtel, C. AU - Davey, R. T., Jr. AU - Falloon, J. AU - Polis, M. A. AU - Walker, R. E. AU - Metcalf, J. A. AU - Davey, V. AU - Piscitelli, S. C. AU - Baseler, M. AU - Dewar, R. AU - Salzman, N. P. AU - Masur, H. AU - Lane, H. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 4 SP - 840 EP - 848 SN - 0022-1899 AD - Kovacs, J. A.: Critical Care Medicine and Pharmacy Departments, Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962005217. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 69655-05-6, 9008-11-1. KW - antiviral agents KW - clinical trials KW - combination therapy KW - didanosine KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunological deficiency KW - immunotherapy KW - interferon KW - patients KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune deficiency KW - immunodeficiency KW - multimodal treatment KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005217&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. AU - Cohen, O. J. AU - Pantaleo, G. AU - Holodniy, M. AU - Fox, C. H. AU - Orenstein, J. M. AU - Schnittman, S. AU - Niu, M. AU - Graziosi, C. AU - Pavlakis, G. N. AU - Lalezari, J. AU - Bartlett, J. A. AU - Steigbigel, R. T. AU - Cohn, J. AU - Novak, R. AU - McMahon, D. AU - Bilello, J. AU - Fauci, A. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 4 SP - 849 EP - 856 SN - 0022-1899 AD - Cohen, O. J.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005218. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 30516-87-1. KW - antiviral agents KW - blood KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - lymph nodes KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005218&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dynamics of virus versus host interaction in children with human immunodeficiency virus type 1 infection. AU - Sei, S. AU - Akiyoshi, H. AU - Bernard, J. AU - Venzon, D. J. AU - Fox, C. H. AU - Schwartzentruber, D. J. AU - Anderson, B. D. AU - Kopp, J. B. AU - Mueller, B. U. AU - Pizzo, P. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 6 SP - 1485 EP - 1490 SN - 0022-1899 AD - Sei, S.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19962006902. Publication Type: Journal Article. Language: English. Number of References: 15 ref. KW - blood KW - children KW - cytokines KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interleukins KW - lymphatic system KW - replication KW - viraemia KW - viral load KW - viral replication KW - USA KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - United States of America KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of a polymerase chain reaction-based assay for diagnosis of Wuchereria bancrofti infection. AU - McCarthy, J. S. AU - Zhong Min AU - Gopinath, R. AU - Ottesen, E. A. AU - Williams, S. A. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 173 IS - 6 SP - 1510 EP - 1514 SN - 0022-1899 AD - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institutes of Health, Bldg. 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19970803666. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - To assess the utility of a polymerase chain reaction (PCR)-based method for diagnosis of Wuchereria bancrofti infection, blood, plasma and paraffin-embedded tissue samples from infected and uninfected subjects were tested using a PCR-based assay that detected a W. bancrofti-specific repetitive DNA sequence. The assay was positive in 100 µl of blood from 40 of 42 microfilaria-positive subjects, the 2 subjects with negative assays having microfilarial counts of 1. Samples from 127 uninfected subjects were PCR-negative. The assay was positive in 7 of 10 daytime samples in regions where infection is nocturnally periodic; PCR amplification from paraffin-embedded sections established the diagnosis of W. bancrofti infection in another 2 cases. A microtitre ELISA plate-based method was developed for rapid evaluation of large numbers of samples. The results suggest that this PCR-based assay will be useful in diagnosis of W. bancrofti infection in a variety of clinical settings. KW - blood KW - blood plasma KW - diagnosis KW - diagnostic techniques KW - ELISA KW - evaluation KW - filariasis KW - helminths KW - human diseases KW - lymphatic filariasis KW - microfilariae KW - parasites KW - polymerase chain reaction KW - tissues KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - enzyme linked immunosorbent assay KW - nematodes KW - parasitic worms KW - PCR KW - plasma (blood) KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803666&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lamivudine in children with human immunodeficiency virus infection: a phase I/II study. AU - Lewis, L. L. AU - Venzon, D. AU - Church, J. AU - Farley, M. AU - Wheeler, S. AU - Keller, A. AU - Rubin, M. AU - Yuen, G. AU - Mueller, B. AU - Sloas, M. AU - Wood, L. AU - Balis, F. AU - Shearer, G. M. AU - Brouwers, P. AU - Goldsmith, J. AU - Pizzo, P. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 1 SP - 16 EP - 25 SN - 0022-1899 AD - Lewis, L. L.: Pediatric Branch, National Cancer Institute, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19962007415. Publication Type: Journal Article. Corporate Author: National Cancer Institute Pediatric Branch Human Immunodeficiency Virus Working Group Language: English. Number of References: 31 ref. Registry Number: 134678-17-4. KW - antiviral agents KW - children KW - clinical trials KW - drug therapy KW - efficacy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - lamivudine KW - pharmacokinetics KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007415&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. AU - Chougnet, C. AU - Wynn, T. A. AU - Clerici, M. AU - Landay, A. L. AU - Kessler, H. A. AU - Rusnak, J. AU - Melcher, G. P. AU - Sher, A. AU - Shearer, G. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 1 SP - 46 EP - 53 SN - 0022-1899 AD - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1360, USA. N1 - Accession Number: 19962007418. Publication Type: Journal Article. Language: English. Number of References: 34 ref. KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - interleukins KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007418&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of immunoreactive tumor necrosis factor-α by a chimeric antibody in patients infected with human immunodeficiency virus type 1. AU - Walker, R. E. AU - Spooner, K. M. AU - Kelly, G. AU - McCloskey, R. V. AU - Woody, J. N. AU - Falloon, J. AU - Baseler, M. AU - Piscitelli, S. C. AU - Davey, R. T., Jr. AU - Polis, M. A. AU - Kovacs, J. A. AU - Masur, H. AU - Lane, H. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 1 SP - 63 EP - 68 SN - 0022-1899 AD - Walker, R. E.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007420. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 308079-78-9. KW - antibodies KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunosuppression KW - tumour necrosis factor KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007420&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Summary of the 31st United States-Japan joint conference on cholera and related diarrheal diseases. AU - Lang, D. R. AU - Guerrant, R. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 3 SP - 451 EP - 455 SN - 0022-1899 AD - Lang, D. R.: Enteric Diseases Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19972001030. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Tropical Diseases N2 - This conference was held at Kiawah Island, South Carolina, USA from 30 November to 3 December 1995. Researchers described substantial advances in cholera epidemiology, detection, molecular mechanisms, and pathophysiology plus new mechanisms for enterotoxigenic, enteroadherent, enterohaemorrhagic and enteroinvasive Escherichia coli. There was also emphasis on new work with and vaccine development with Bacteroides fragilis and Yersinia, Shigella and Salmonella species. KW - bacterial diseases KW - cholera KW - detection KW - diagnosis KW - diarrhoea KW - epidemiology KW - human diseases KW - pathogenesis KW - research KW - vaccine development KW - bacteroides fragilis KW - escherichia coli KW - man KW - salmonella KW - shigella KW - vibrio cholerae KW - Bacteroides KW - Bacteroidaceae KW - Bacteroidales KW - Bacteroidetes (class) KW - Bacteroidetes (phylum) KW - Bacteria KW - prokaryotes KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - bacterial infections KW - bacterioses KW - bacterium KW - diarrhea KW - E. coli KW - scouring KW - studies KW - United States-Japan joint conference on cholera and related diarrheal diseases KW - yersinia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001030&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for protective immunity to bancroftian filariasis in the Cook Islands. AU - Steel, C. AU - Guinea, A. AU - Ottesen, E. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 3 SP - 598 EP - 605 SN - 0022-1899 AD - Steel, C.: Laboratory of Parasitic Diseases, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970800694. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2. Subject Subsets: Helminthology; Tropical Diseases N2 - To challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a Wuchereria bancrofti endemic island in the Cook Islands, who had been diagnosed 17 years earlier as putatively immune endemic normals (PI/EN), were re-examined. Even with continued exposure to infection, all 19 had maintained their apparent infection-free status. Studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation and cytokine [interleukin (IL)-2, IL-5, IL-10, interferon-γ and granulocyte-macrophage colony-stimulating factor] responses in peripheral blood mononuclear cells) to adult- and microfilarial-stage antigens, but not antibody responses, were markedly greater in the PI/EN group than in a group of 20 age-matched, infected patients. Furthermore, the PI/EN group was comprised of high- and low-responding individuals who were clinically indistinguishable. The results provide evidence that protective immunity to lymphatic filariasis does occur and that it is probably T cell-mediated. KW - antibodies KW - antigens KW - bancroftian filariasis KW - blood cells KW - colony stimulating factor KW - cytokines KW - filariasis KW - helminths KW - human diseases KW - immune response KW - immunity KW - immunology KW - interferon KW - interleukin 10 KW - interleukin 2 KW - interleukin 5 KW - interleukins KW - lymphatic filariasis KW - nematode infections KW - parasites KW - T lymphocytes KW - Cook Islands KW - Oceania KW - man KW - Nematoda KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Developing Countries KW - New Zealand Oceania KW - Oceania KW - Polynesia KW - Pacific Islands KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800694&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiologic determinants of seroreactivity to human papillomavirus (HPV) type 16 virus-like particles in cervical HPV-16 DNA-positive and -negative women. AU - Wideroff, L. AU - Schiffman, M. H. AU - Hoover, R. AU - Tarone, R. E. AU - Nonnenmacher, B. AU - Hubbert, N. AU - Kirnbauer, R. AU - Greer, C. E. AU - Lorincz, A. T. AU - Manos, M. M. AU - Glass, A. G. AU - Scott, D. R. AU - Sherman, M. E. AU - Buckland, J. AU - Lowy, D. AU - Schiller, J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 5 SP - 937 EP - 943 SN - 0022-1899 AD - Wideroff, L.: Epidemiology and Biostatistics Program, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, USA. N1 - Accession Number: 19972000790. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health N2 - The epidemiological determinants of seroreactivity to human papillomavirus (HPV) type 16 L1/L2 virus-like particles (VLPs) were assessed separately in HPV-16 DNA-positive and -negative women participating in a nested case-control study of incident cervical neoplasia in Oregon, USA. 74 women with cervical HPV-16 DNA and 656 cytologically normal HPV-16 DNA-negative subjects were interviewed and tested at 2 time points for viral DNA and once (at the later time) for VLP seroreactivity. Among subjects who were currently HPV-16 DNA-negative, seroreactivity odds ratios increased from 2.9 for 2-5 male sex partners (vs. 0 or 1) to 5.4 for 6-9 partners and 14.0 for ≥10. Thus, prior cervical infection may be a major determinant of seroreactivity in HPV-16 DNA-negative women. This trend was not observed in HPV-16 DNA-positive subjects. Seroreactivity was independently associated with oral contraceptive use, particularly in HPV-16 DNA-negative subjects with use for ≥10 years. Consequently, a possible role for virus-steroid hormone interactions in seroconversion is suggested. KW - cervix KW - epidemiology KW - human diseases KW - immune response KW - seroprevalence KW - viral diseases KW - virus-like particles KW - women KW - North America KW - Oregon KW - USA KW - human papillomavirus 16 KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Papillomaviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - human papillomavirus KW - immunity reactions KW - immunological reactions KW - Papovaviridae KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000790&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy. AU - Sei, S. AU - Stewart, S. K. AU - Farley, M. AU - Mueller, B. U. AU - Lane, J. R. AU - Robb, M. L. AU - Brouwers, P. AU - Pizzo, P. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 6 SP - 1200 EP - 1206 SN - 0022-1899 AD - Sei, S.: Pediatric Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19972001575. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 63231-63-0, 30516-87-1. N2 - The amount of HIV-1 RNA and presence of the mutation conferring viral resistance to zidovudine were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children with or without encephalopathy. The presence of zidovudine-resistant HIV-1 in CSF affecting the neurological outcome during treatment with zidovudine was also examined. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n=25; median, 430 copies/ml; range 0-22 × 105 copies/ml) followed by the moderately encephalopathic (n=7; median, 330; range 0-1130) and non-encephalopathic groups (n=9; median, 0; range, 0-566) (P=0.007). There was no correlation between CSF and plasma HIV-1 RNA levels. Five of 7 children with wild type codon 215 had improved or stable disease during zidovudine treatment (P=0.007). It is suggested that increased viral replication and emergence of drug-resistant HIV-1 variants within the central nervous system may play a role in progression of HIV encephalopathy. KW - antiviral agents KW - blood plasma KW - body parts KW - central nervous system KW - cerebrospinal fluid KW - children KW - clinical aspects KW - disease course KW - drug resistance KW - drug therapy KW - encephalopathy KW - evaluation KW - human immunodeficiency viruses KW - mutations KW - nervous system KW - replication KW - resistance KW - rna KW - treatment KW - viral replication KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - chemotherapy KW - clinical picture KW - CNS KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - plasma (blood) KW - ribonucleic acid KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001575&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Perspective: prospects for development of vaccines against human helminth infections. AU - McCarthy, J. S. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1996/// VL - 174 IS - 6 SP - 1384 EP - 1390 SN - 0022-1899 AD - McCarthy, J. S.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970805828. Publication Type: Journal Article. Language: English. Number of References: 89 ref. Subject Subsets: Helminthology N2 - The prospects for the development of vaccines against human helminth infections are discussed under the following headings: strategies for disease control; naturally acquired human immunity; immune effector mechanisms in human helminth infection; animal models of immunity in helminth infections; strategies to identify helminth antigens as possible vaccine targets; progress towards the development of helminth vaccines; and other approaches to vaccine development. KW - helminths KW - human diseases KW - immunity KW - parasites KW - vaccination KW - vaccine development KW - vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - general account KW - parasitic worms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805828&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. AU - Stevenson, B. AU - Tilly, K. AU - Rosa, P. A. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1996/// VL - 178 IS - 12 SP - 3508 EP - 3516 SN - 0021-9193 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19960505123. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology N2 - The authors identified 4 loci in B. burgdorferi B31 that contain open reading frames capable of encoding 6 proteins that are related to the antigenic proteins OspE and OspF. These proteins were designated Erp, for OspEF-related protein, and their respective genes named erp. The erpA and erpB genes are linked, as are erpC and erpD, and the pairs probably constitute 2 operons. The erpG and erpH genes appear to be monocistronic. The ErpA and ErpC proteins are expressed by B. burgdorferi B31 in culture and are recognized by a polyclonal antiserum raised against the OspE protein of B. burgdorferi N40. The 4 erp loci are each located on different 32-kb circular plasmids that contain additional DNA sequences that are homologous to each other and to an 8.3-kb circular plasmid of B. burgdorferi s.l. Ip21. All four 32-kb plasmids can be maintained within a single bacterium, which may provide a model for the study of plasmid replication and segregation in B. burgdorferi. KW - amino acid sequences KW - antigens KW - DNA KW - genes KW - nucleotide sequences KW - open reading frames KW - plasmids KW - proteins KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - deoxyribonucleic acid KW - DNA sequences KW - immunogens KW - ORFs KW - outer surface proteins KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960505123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A developmental stage-specific histone H1 homolog of Coxiella burnetii. AU - Heinzen, R. A. AU - Hackstadt, T. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1996/// VL - 178 IS - 16 SP - 5049 EP - 5052 SN - 0021-9193 AD - Heinzen, R. A.: Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19970501301. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology N2 - Two DNA-binding proteins were detected in C. burnetii by Southwestern (DNA-protein) blotting. One of these, termed Hq1, is enriched in the small cell variant stage of the developmental cycle and displays compositional and primary amino acid sequence similarities to eukaryotic histone H1. C. burnetii appears to be another example of an intracellular parasite with morphologically distinct developmental forms whose nucleoid structure may be controlled by histone H1 homologues. KW - amino acid sequences KW - binding proteins KW - clones KW - DNA KW - histones KW - molecular genetics KW - nucleotide sequences KW - Coxiella KW - Coxiella burnetii KW - Coxiellaceae KW - Legionellales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Coxiella KW - bacterium KW - biochemical genetics KW - carrier proteins KW - deoxyribonucleic acid KW - DNA sequences KW - Hq1 KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501301&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi. AU - Rosa, P. AU - Samuels, D. S. AU - Hogan, D. AU - Stevenson, B. AU - Casjens, S. AU - Tilly, K. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1996/// VL - 178 IS - 20 SP - 5946 EP - 5953 SN - 0021-9193 AD - Rosa, P.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19970501820. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 4434-05-3, 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - The authors investigated gene inactivation by allelic exchange using a mutated borrelial gyrB gene that confers resistance to the antibiotic coumermycin A1 as a selectable marker. B. burgdorferi was transformed by electroporation with a linear fragment of DNA in which this selectable marker was flanked by sequences from a native borrelial 26-kb circular plasmid. Coumermycin A1-resistant transformants were identified in which gyrB had interrupted the targeted site on the 26-kb plasmid via homologous recombination with the flanking sequences. Antibiotic resistance conferred by the mutated gyrB gene on the plasmid was dominant, and transformed spirochaetes carrying this plasmid did not contain any unaltered copies of the plasmid. Coumermycin A1 resistance can be transferred to naive B. burgdorferi by transformation with borrelial plasmid DNA from the initial transformants. This work represents the first example of a directed mutation in B. burgdorferi whereby a large segment of heterologous DNA (gyrB) has been inserted via homologous recombination with flanking sequences, thus demonstrating the feasibility of specific gene inactivation by allelic exchange. KW - antibiotics KW - biotechnology KW - coumamycin KW - DNA KW - electroporation KW - genes KW - genetic engineering KW - genetic markers KW - mutations KW - plasmids KW - recombination KW - resistance KW - targeted mutagenesis KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - coumermycin KW - deoxyribonucleic acid KW - gene inactivation KW - genetic manipulation KW - genetic recombination KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501820&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. AU - Carrera, L. AU - Gazzinelli, R. T. AU - Badolato, R. AU - Hieny, S. AU - Müller, W. AU - Kühn, R. AU - Sacks, D. L. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 183 IS - 2 SP - 515 EP - 526 SN - 0022-1007 AD - Carrera, L.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19960803507. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Protozoology; Tropical Diseases N2 - Leishmania major promastigotes were found to avoid activation of mouse bone marrow-derived macrophages (BMMø) in vitro for production of cytokines that are typically induced during infection with other intracellular pathogens. Coexposure of BMMø to L. major and other microbial stimuli resulted in complete inhibition of interleukin (IL)-12(p40) mRNA induction and IL-12 release. In contrast, mRNA and protein levels for IL-1α, IL-1β, tumour necrosis factor (TNF)-α and inducible NO synthase (iNOS) were only partially reduced, and signals for IL-10 and monocyte chemoattractant protein (MCP-1/JE) were enhanced. L. major provided a detectable trigger for TNF-α and iNOS in BMMø primed with interferon (IFN)-γ but still failed to induce IL-12. Thus IL-12 induction was selectively impaired after infection, whereas activation pathways for other monokine responses remained relatively intact. Selective and complete inhibition of IL-12(p40) induction was observed using BMMø from either genetically susceptible or resistant mouse strains, as well as IL-10 knockout mice, and was obtained using promastigotes from cutaneous, visceral and lipophosphoglycan-deficient strains of L. major and L. donovani. The impaired production of the major physiological inducer of IFN-γ may underlie the relatively prolonged interval of parasite intracellular survival and replication that is typically associated with leishmanial infections, including those producing self-limiting disease. KW - bone marrow KW - cytokines KW - immune response KW - in vitro KW - interferon KW - interleukin 1 KW - interleukin 12 KW - interleukins KW - lymphokines KW - macrophages KW - messenger rna KW - monokines KW - parasites KW - promastigotes KW - tumour necrosis factor KW - Leishmania donovani KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - cachectin KW - cachexin KW - immunity reactions KW - immunological reactions KW - mRNA KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803507&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation. AU - Weissman, D. AU - Barker, T. D. AU - Fauci, A. S. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 183 IS - 2 SP - 687 EP - 692 SN - 0022-1007 AD - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005167. Publication Type: Journal Article. Language: English. Number of References: 33 ref. KW - antigens KW - CD4+ lymphocytes KW - dendritic cells KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunogens KW - immunological reactions KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005167&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of variants of the major surface glycoprotein of Pneumocystis carinii. AU - Angus, C. W. AU - Tu, A. AU - Vogel, P. AU - Qin, M. AU - Kovacs, J. A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 183 IS - 3 SP - 1229 EP - 1234 SN - 0022-1007 AD - Angus, C. W.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961201213. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A multicopy family of related but unique genes encodes the major surface glycoprotein (MSG) of P. carinii. To examine whether different members of this gene family are expressed by P. carinii, antisera were prepared against peptides whose sequences were determined from the deduced amino acid sequences of variants of rat-derived MSG. Immunohistochemical staining of serial sections of lungs of infected rats showed that at least 3 variants of MSG were expressed in an individual lobe, that there was a focal expression of these variants within the lung, and that the relative numbers of these foci were different. Indirect immunofluorescent staining of purified P. carinii using these antisera revealed that at least 3 variants of MSG were present in organisms isolated from an individual rat and that both cysts and trophozoites reacted with each antiserum. A substantial difference in the fraction of organisms reacting with a specific antipeptide antiserum was seen when comparing organisms isolated from rats raised in a single colony over a period of 2 yr as well as organisms isolated at one time point from rats raised in different colonies. It is suggested that P. carinii utilizes antigenic variation for evading host defense mechanisms. KW - antigens KW - gene expression KW - genes KW - glycoproteins KW - immunology KW - infections KW - mycoses KW - pneumocystosis KW - fungi KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - rats KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - antigenicity KW - fungus KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in macrophages in vivo. AU - Gazzinelli, R. T. AU - Sher, A. AU - Cheever, A. AU - Gerstberger, S. AU - Martin, M. A. AU - Dickie, P. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 183 IS - 4 SP - 1645 EP - 1655 SN - 0022-1007 AD - Gazzinelli, R. T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970800447. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Protozoology N2 - Human immunodeficiency virus (HIV)-1 transgenic mice expressing low or undetectable levels of viral mRNA in lymphoid tissue were each infected with 20 cysts of Toxoplasma gondii (avirulent strain ME-49). Exposure to the parasite resulted in an increase in HIV-1 transcripts in lymph nodes, spleen and lungs during the acute phase of infection and in the central nervous system during the chronic stage of disease. In vivo and ex vivo experiments identified macrophages as a major source of the induced HIV-1 transcripts. In contrast, T. gondii infection failed to stimulate HIV-1 transcription in tissues of 2 HIV-1 transgenic mouse strains harbouring a HIV-1 proviral DNA in which the nuclear factor (NF)-κB binding motifs from the viral long terminal repeats had been replaced with a duplicated Moloney murine leukaemia virus core enhancer. A role for NF-κB in the activation of HIV-1 by T. gondii was also suggested by the simultaneous induction of NF-κB binding activity and tumour necrosis factor-α synthesis in transgenic mouse macrophages stimulated by exposure to parasite extracts. The results demonstrate the potential of an opportunistic pathogen to induce HIV-1 transcription in vivo and suggest a mechanism for the dissemination of HIV-1 by macrophages. KW - acute course KW - central nervous system KW - chronic course KW - DNA KW - experimental infections KW - host parasite relationships KW - human immunodeficiency viruses KW - laboratory animals KW - lungs KW - lymph nodes KW - macrophages KW - molecular genetics KW - opportunistic infections KW - parasites KW - RNA KW - spleen KW - transcription KW - mice KW - protozoa KW - Toxoplasma gondii KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - biochemical genetics KW - CNS KW - deoxyribonucleic acid KW - DNA transcription KW - human immunodeficiency virus KW - parasite host relationships KW - ribonucleic acid KW - severe course KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects. AU - Marzo Veronese, F. di AU - Arnott, D. AU - Barnaba, V. AU - Loftus, D. J. AU - Sakaguchi, K. AU - Thompson, C. B. AU - Salemi, S. AU - Mastroianni, C. AU - Sette, A. AU - Shabanowitz, J. AU - Hunt, D. F. AU - Appella, E. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 183 IS - 6 SP - 2509 EP - 2516 SN - 0022-1007 AD - Marzo Veronese, F. di: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006311. Publication Type: Journal Article. Language: English. Number of References: 25 ref. KW - cytotoxic T lymphocytes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - peptides KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - vinculin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The domain on the duffy blood group antigen for binding Plasmodium vivax and P. knowlesi malarial parasites to erythrocytes. AU - Chitnis, C. E. AU - Chaudhuri, A. AU - Horuk, R. AU - Pogo, A. O. AU - Miller, L. H. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1996/// VL - 184 IS - 4 SP - 1531 EP - 1536 SN - 0022-1007 AD - Chitnis, C. E.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19970800395. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - Plasmodium vivax and P. knowlesi use the Duffy blood group antigen as a receptor to invade human erythrocytes and region II of the parasite ligands for binding to this erythrocyte receptor. The peptide within the Duffy blood group antigen of human and rhesus erythrocytes to which the P. vivax and P. knowlesi ligands bind was identified. Peptides from the NH2-terminal extracellular region of the Duffy antigen were tested for their ability to block the binding of erythrocytes to transfected Cos cells expressing on their surface region II of the Duffy-binding ligands. The binding site on the human Duffy antigen used by both the P. vivax and P. knowlesi ligands mapped to a 35-amino acid region. A 34-amino acid peptide from the equivalent region of the rhesus Duffy antigen blocked the binding of P. vivax to human erythrocytes, although the P. vivax ligand expressed on Cos cells did not bind rhesus erythrocytes. The binding of the rhesus peptide, but not the rhesus erythrocyte, to the P. vivax ligand was explained by interference of carbohydrate with the binding process. Rhesus erythrocytes, treated with N-glycanase, bound specifically to P. vivax region II. Thus, the interaction of P. vivax ligand with human and rhesus erythrocytes appears to be mediated by a peptide-peptide interaction. Glycosylation of the rhesus Duffy antigen appears to block binding of the P. vivax ligand to rhesus erythrocytes. KW - amino acid sequences KW - antigens KW - binding KW - blood KW - blood group antigens KW - cell cultures KW - cell invasion KW - erythrocyte invasion KW - erythrocytes KW - host parasite relationships KW - in vitro KW - ligands KW - parasites KW - peptides KW - receptors KW - Macaca mulatta KW - man KW - Plasmodium knowlesi KW - Plasmodium vivax KW - protozoa KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - antigenicity KW - blood red cells KW - immunogens KW - parasite host relationships KW - protein sequences KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800395&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic variants of human T-lymphotropic virus type II in American Indian groups. AU - Biggar, R. J. AU - Taylor, M. E. AU - Neel, J. V. AU - Hjelle, B. AU - Levine, P. H. AU - Black, F. L. AU - Shaw, G. M. AU - Sharp, P. M. AU - Hahn, B. H. JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 216 IS - 1 SP - 165 EP - 173 SN - 0042-6822 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19962008118. Publication Type: Journal Article. Language: English. Number of References: 33 ref. KW - epidemiology KW - ethnic groups KW - genetic variation KW - HTLV-II infections KW - human diseases KW - nucleotide sequences KW - phylogenetics KW - Deltaretrovirus KW - human t-cell lymphotropic virus type ii KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - DNA sequences KW - genetic variability KW - genotypic variability KW - genotypic variation KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008118&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs. AU - Semmes, O. J. AU - Majone, F. AU - Cantemir, C. AU - Turchetto, L. AU - Hjelle, B. AU - Jeang KuanTeh JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 217 IS - 1 SP - 373 EP - 379 SN - 0042-6822 AD - Semmes, O. J.: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962008959. Publication Type: Journal Article. Language: English. Number of References: 52 ref. KW - genomes KW - HTLV infections KW - human diseases KW - pathogenesis KW - Tax protein KW - transcription KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - human t-cell lymphotropic virus type ii KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - DNA transcription KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - long terminal repeat KW - micronuclei KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008959&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues. AU - Delahunty, M. D. AU - Rhee, I. AU - Freed, E. O. AU - Bonifacino, J. S. JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 218 IS - 1 SP - 94 EP - 102 SN - 0042-6822 AD - Delahunty, M. D.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19962007007. Publication Type: Journal Article. Language: English. Number of References: 47 ref. KW - amino acid sequences KW - envelope protein gp41 KW - HIV-1 infections KW - human diseases KW - mutations KW - pathogenesis KW - syncytia KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - gp41 KW - human immunodeficiency virus type 1 KW - membrane fusion KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007007&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma. AU - Morton, R. L. AU - David, H. AU - O'Connor, P. M. AU - Bustin, M. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1996/// VL - 222 IS - 2 SP - 368 EP - 373 SN - 0006-291X AD - Morton, R. L.: National Cancer Institute, National Institutes of Health, Bethesda MD 20852, USA. N1 - Accession Number: 19992005600. Publication Type: Journal Article. Language: English. Number of References: 19 ref. KW - Burkitt's lymphoma KW - cell cycle KW - human diseases KW - lymphoma KW - protein synthesis KW - proteins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - protein biosynthesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005600&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human fetal glial cells constitutively produce HIV-inducing cytokines. AU - Kalebic, T. JO - Experimental Cell Research JF - Experimental Cell Research Y1 - 1996/// VL - 223 IS - 2 SP - 452 EP - 458 SN - 0014-4827 AD - Kalebic, T.: Laboratory of Molecular Oncology, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962009313. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9068-38-6. KW - antibodies KW - antigens KW - cell lines KW - cytokines KW - fetus KW - human immunodeficiency viruses KW - neuroglia KW - reverse transcriptase KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenicity KW - foetus KW - glial cells KW - human immunodeficiency virus KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of CD26 does not correlate with the replication of macrophage-tropic strains of HIV-1 in T-cell lines. AU - Watkins, B. A. AU - Crowley, R. W. AU - Davis, A. E. AU - Louie, A. T. AU - Reitz, M. S., Jr. JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 224 IS - 1 SP - 276 EP - 280 SN - 0042-6822 AD - Watkins, B. A.: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19972002669. Publication Type: Journal Article. Language: English. Number of References: 37 ref. KW - CD4+ lymphocytes KW - human diseases KW - macrophages KW - proteinases KW - replication KW - strains KW - surface antigens KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4+ cells KW - human immunodeficiency virus type 1 KW - proteases KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002669&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutational analysis of a neutralization epitope on the dengue type 2 virus (DEN2) envelope protein: monoclonal antibody resistant DEN2/DEN4 chimeras exhibit reduced mouse neurovirulence. AU - Hiramatsu, K. AU - Tadano, M. AU - Men, R. AU - Lai ChingJuh JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 224 IS - 2 SP - 437 EP - 445 SN - 0042-6822 AD - Hiramatsu, K.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970501469. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology KW - amino acids KW - analysis KW - arboviruses KW - envelope proteins KW - epitopes KW - monoclonal antibodies KW - mutations KW - neutralization KW - viral proteins KW - viral structural proteins KW - virulence KW - dengue 2 virus KW - dengue 4 virus KW - dengue virus KW - mice KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - arthropod-borne viruses KW - neurovirulence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501469&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein. AU - Portis, J. L. AU - Fujisawa, R. AU - McAtee, F. J. JO - Virology (New York) JF - Virology (New York) Y1 - 1996/// VL - 226 IS - 2 SP - 384 EP - 392 SN - 0042-6822 AD - Portis, J. L.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19972001576. Publication Type: Journal Article. Language: English. KW - central nervous system KW - gag protein KW - microbiology KW - mutants KW - pathogenesis KW - proteins KW - structural genes KW - retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CNS KW - MuLV KW - other Retroviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001576&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting. AU - Soh YunJo AU - Rhee, H. M. AU - Sohn DongHwan AU - Song, B. J. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1996/// VL - 227 IS - 2 SP - 541 EP - 546 SN - 0006-291X AD - Soh YunJo: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA. N1 - Accession Number: 19991409706. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9035-51-2, 64-17-5. Subject Subsets: Human Nutrition KW - cytochrome P-450 KW - ethanol KW - fasting KW - induction KW - lymphocytes KW - messenger RNA KW - regulation KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ethyl alcohol KW - mRNA KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409706&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Monitoring cleavage of fusion proteins by matrix-assisted laser desorption ionization/mass spectrometry: recombinant HIV-1IIIB p26. AU - Parker, C. E. AU - Papac, D. I. AU - Tomer, K. B. JO - Analytical Biochemistry JF - Analytical Biochemistry Y1 - 1996/// VL - 239 IS - 1 SP - 25 EP - 34 SN - 0003-2697 AD - Parker, C. E.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19972001092. Publication Type: Journal Article. Language: English. Number of References: 21 ref. KW - enzymology KW - fusion proteins KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - laboratory methods KW - mass spectrometry KW - monitoring KW - proteins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - laboratory techniques KW - surveillance systems KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001092&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gender differences in muscle sympathetic nerve activity: effect of body fat distribution. AU - Jones, P. P. AU - Snitker, S. AU - Skinner, J. S. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1996/// VL - 270 IS - 2 SP - E363 EP - E366 SN - 0002-9513 AD - Jones, P. P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85016, USA. N1 - Accession Number: 19961404131. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition N2 - Microneurography, hydrodensitometry and waist-to-hip ratio (W/T) measures were obtained in 14 men (24±2 years old) and 14 women (27±3 years old) with a large range of percent body fat (%BF) and W/T. Regression analyses revealed positive correlations between muscle sympathetic nerve activity (MSNA) and %BF in men (r = 0.55, P=0.04) and in women (r = 0.63, P=0.02), with no difference in the slopes of the regression lines but a higher intercept in men (P<0.01). When genders were pooled, MSNA and W/T were correlated (r = 0.68, P<0.0001); this positive correlation was also found in men (r = 0.57, P=0.04) but not as strongly in women (r = 0.49, P=0.07). Forward stepwise multiple-regression analysis using %BF, W/T, gender and age indicated that W/T was the primary factor related to MSNA (R² = 0.46); the other factors were not independent predictors. It is concluded that %BF is related to MSNA in both sexes but that the regression line is shifted downward in women because of lower levels of MSNA. W/T is a better correlate of MSNA than %BF and partially explains the higher MSNA in men. The findings may be relevant to the cardiovascular and metabolic disease risk associated with abdominal obesity. KW - body composition KW - body fat KW - distribution KW - muscles KW - sex differences KW - sympathetic nervous system KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404131&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin. AU - Otteken, A. AU - Moss, B. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 1 SP - 97 EP - 103 SN - 0021-9258 AD - Otteken, A.: Laboratory of Viral Disease, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002904. Publication Type: Journal Article. Language: English. Number of References: 32 ref. KW - acquired immune deficiency syndrome KW - binding KW - envelope proteins KW - HIV infections KW - human diseases KW - molecular biology KW - proteins KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - calnexin KW - calreticulin KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cataractogenesis in transgenic mice containing the HIV-1 protease linked to the lens αA-crystallin promoter. AU - Tumminia, S. J. AU - Jonak, G. J. AU - Focht, R. J. AU - Cheng, Y. S. E. AU - Russell, P. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 1 SP - 425 EP - 431 SN - 0021-9258 AD - Tumminia, S. J.: Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002905. Publication Type: Journal Article. Language: English. Number of References: 36 ref. KW - cataract KW - eye diseases KW - eye lens KW - genetically engineered organisms KW - human diseases KW - pathogenesis KW - proteinases KW - transgenic animals KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GMOs KW - HIV-1/HIV infections KW - proteases KW - transgenic organisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002905&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of glucocorticoids on energy metabolism and food intake in humans. AU - Tataranni, P. A. AU - Larson, D. E. AU - Snitker, S. AU - Young, J. B. AU - Flatt, J. P. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1996/// VL - 271 IS - 2 SP - E317 EP - E325 SN - 0002-9513 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19961410170. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 50-24-8, 5060-55-9, 52-21-1, 51-40-1, 630-67-1, 1107-99-9, 69815-49-2, 125-02-0, 51-41-2. Subject Subsets: Human Nutrition N2 - The effect of glucocorticoid administration on energy metabolism and food intake was studied in 20 healthy, nondiabetic Caucasian male subjects (27±5 (SD) years old, 72±9 kg, 20±7% body fat) randomly and blindly assigned to glucocorticoid (methylprednisolone, METH; n=10) or placebo (PLAC; n=10) treatment. Each subject was studied twice: during a weight maintenance diet and during ad libitum food intake. Energy metabolism was measured by indirect calorimetry and food intake by an automated food-selection system. 24-h urinary norepinephrine excretion (24-h NE) was used as an estimate of sympathetic nervous system activity. During weight maintenance, METH intravenous infusion (125 mg/30 min) increased energy expenditure compared with PLAC, and after 4 days of oral therapy, METH (40 mg/day) decreased 24-h NE and increased energy expenditure compared with PLAC. During ad libitum food intake, after 4 days of METH (40 mg/day) or PLAC oral therapy, both groups increased their energy intake over weight maintenance, but the increase was larger in the METH group than the PLAC group (4554±1857 vs. 2867±846 kcal/day; P=0.04). The data suggest that therapeutic doses of glucocorticoids induce obesity mostly by increasing energy intake, an effect which may be related to the ability of glucocorticoids to act directly or indirectly on the central regulation of appetite. KW - appetite KW - calorimetry KW - energy intake KW - energy metabolism KW - excretion KW - food intake KW - glucocorticoids KW - norepinephrine KW - obesity KW - prednisolone KW - sympathetic nervous system KW - urine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorimetric methods KW - fatness KW - noradrenaline KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation. AU - Wondrak, E. M. AU - Nashed, N. T. AU - Haber, M. T. AU - Jerina, D. M. AU - Louis, J. M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 8 SP - 4477 EP - 4481 SN - 0021-9258 AD - Wondrak, E. M.: Molecular Mechanisms of Development Section, Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005597. Publication Type: Journal Article. Language: English. Number of References: 23 ref. KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - precursors KW - proteinases KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005597&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 protein expression from synthetic circles of DNA mimicking the extrachromosomal forms of viral DNA. AU - Cara, A. AU - Cereseto, A. AU - Lori, F. AU - Reitz, M. S., Jr. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 10 SP - 5393 EP - 5397 SN - 0021-9258 AD - Cara, A.: Laboratory of Tumor Cell Biology, NCI, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19962005774. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. KW - DNA KW - genes KW - HIV-1 infections KW - human immunodeficiency viruses KW - proteins KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005774&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. AU - Yang NengYu AU - Shigeta, H. AU - Shi HuiPing AU - Teng, C. T. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 10 SP - 5795 EP - 5804 SN - 0021-9258 AD - Yang NengYu: Gene Regulation Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. N1 - Accession Number: 19960402852. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 9007-49-2, 339615-76-8. Subject Subsets: Dairy Science N2 - A DNA sequence (-418 to -378, FP1), upstream from the imperfect oestrogen response element (ERE) at the 5′-flanking region of the human lactoferrin gene in RL95-2 endometrium carcinoma cells was examined. Electrophoresis mobility shift assay, site-directed mutagenesis and DNA methylation interference analyses were used. The nuclear protein binding elements in the FP1 region were mapped. Three nuclear proteins bound to the FP1 region (C1, C2 and C3 sites). The nuclear receptor, chicken ovalbumin upstream promoter-transcription factor, bound to the C2 site. Mutations in the C1 binding region abolished C1 complex formation and reduced oestrogen-dependent transcription from the lactoferrin ERE. When the imperfect ERE of the lactoferrin gene was converted to a perfect palindromic structure, the enhancing effect of the C1 binding element for oestrogen responsiveness was abolished. A complementary DNA (cDNA) clone was isolated from an RL95-2 expression library encoding the C1 site-binding protein. The encoded polypeptide maintained 99% amino acid identity with a previously described orphan nuclear oestrogen-related receptor (hERR1). A 2.2-kb messenger RNA was detected in RL95-2 cells by the newly isolated cDNA but not by the first 180 bp of the published hERR1 sequence. By Western analysis, a major 42-kDa protein was detected in the RL95-2 nuclear extract with antibody generated against glutathione S-transferase-hERR1 fusion protein. hERR1 interacted with the human oestrogen receptor through protein-protein contacts. The nucleotide sequences reported were submitted to the GenBank/EMBL Data Bank with accession number L38487 (Genome Sequence Data Base). KW - binding KW - cell culture KW - cells KW - complementary dna KW - dna KW - endometrium KW - gene expression KW - hormonal control KW - lactoferrin KW - neoplasms KW - nucleic acids KW - nucleotide sequences KW - oestrogen receptors KW - oestrogens KW - promoters KW - receptors KW - regulators KW - transcription KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cDNA KW - deoxyribonucleic acid KW - DNA sequences KW - DNA transcription KW - endocrine control KW - endometrial area KW - estrogen receptors KW - estrogens KW - governors KW - hormonal regulation KW - promoter region KW - promoter sequences KW - Human Physiology and Biochemistry (VV050) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960402852&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A soluble active mutant of HIV-1 integrase. Involvement of both the core and carboxyl-terminal domains in multimerization. AU - Jenkins, T. M. AU - Engelman, A. AU - Ghirlando, R. AU - Craigie, R. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 13 SP - 7712 EP - 7718 SN - 0021-9258 AD - Jenkins, T. M.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-0560, USA. N1 - Accession Number: 19962006807. Publication Type: Journal Article. Language: English. Number of References: 42 ref. KW - HIV-1 infections KW - human diseases KW - mutations KW - solubility KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006807&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell leukemia virus type I Tax masks c-Myc function through a cAMP-dependent pathway. AU - Semmes, O. J. AU - Barrett, J. F. AU - Dang, C. V. AU - Jeang KuanTeh JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 16 SP - 9730 EP - 9738 SN - 0021-9258 AD - Semmes, O. J.: Laboratory of Molecular Microbiology, Molecular Virology Section, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962006198. Publication Type: Journal Article. Language: English. Number of References: 95 ref. Registry Number: 60-92-4. KW - c-amp KW - genes KW - htlv infections KW - human diseases KW - mutants KW - regulatory genes KW - tax gene KW - Deltaretrovirus KW - human t-cell lymphotropic virus KW - retroviridae KW - Deltaretrovirus KW - viruses KW - RNA Reverse Transcribing Viruses KW - Retroviridae KW - cyclic adenosine monophosphate KW - cyclic AMP KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006198&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells. AU - Baier, L. J. AU - Bogardus, C. AU - Sacchettini, J. C. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 18 SP - 10892 EP - 10896 SN - 0021-9258 AD - Baier, L. J.: NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19961408733. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - A polymorphism in the gene that encodes human intestinal fatty acid binding protein (IFABP) results in an alanine (Ala54) to threonine (Thr54) substitution at codon 54 that alters the in vitro binding affinity of the protein for long-chain fatty acids. To identify potential functional variability between Ala54 and Thr54 IFABP, permanently transfected Caco-2 cell lines that express either Ala54 or Thr54 IFABP were established. Caco-2 cells that expressed Thr54 IFABP transported long-chain fatty acids and secreted triglycerides to a greater degree than Caco-2 cells expressing Ala54 IFABP. It was concluded that IFABP participates in the intracellular transport of long-chain fatty acids. In addition, the observed increase in transport of fatty acids across cells expressing Thr54 IFABP suggests a plausible physiological mechanism for the observation that Pima Indians with a Thr54 IFABP genotype have increased post-absorptive lipid oxidation rates and are more insulin-resistant than Pima Indians with a Ala54 IFABP genotype. KW - binding proteins KW - cell cultures KW - cell lines KW - fatty acids KW - genetic polymorphism KW - insulin KW - lipid metabolism KW - long chain fatty acids KW - mutants KW - resistance KW - secretion KW - transport KW - triacylglycerols KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - fat metabolism KW - transportation KW - triglycerides KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408733&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4. AU - Robey, F. A. AU - Harris-Kelson, T. AU - Robert-Guroff, M. AU - Batinic´, D. AU - Ivanov, B. AU - Lewis, M. S. AU - Roller, P. P. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 30 SP - 17990 EP - 17995 SN - 0021-9258 AD - Robey, F. A.: Peptide and Immunochemistry Unit, NIDR, National Institutes of Health Bethesda, Maryland 20892. N1 - Accession Number: 19982002231. Publication Type: Journal Article. Language: English. N2 - The fourth conserved domain of the human immunodeficiency virus type 1 (HIV-1) envelope, the C4 region of glycoprotein 120 (gp120), is believed to be a major part of gp120 that is necessary for binding to CD4. Recently, we found that C4 in gp120 is probably an α-helix, because antibodies made against helical constructs of C4 react with native and recombinant gp120 but antibodies against linear C4 constructs do not. For the present study, we performed experiments to determine, first, if CD4 could bind to the helical C4 constructs and, second, if the binding was comparable with CD4 binding to gp120. Immobilized helical constructs derived from the C4s from HIV-1 and HIV-2 bound biotinylated recombinant CD4 with Kd values of 8.59 nM and 14.59 n, respectively. Recombinant soluble CD4 inhibited the binding of biotinylated CD4 to the C4 construct from HIV-1 with a Kd of 9.88 n, and recombinant gp120 blocked the binding of CD4 to the immobilized helical construct from C4 of HIV-1 with a Kd of 8.08 n. The C4 peptide-(419-436) from HIV-1 (KIKQIINMWQEVGKAMYA-NH2) blocked CD4 binding to gp120 but only in a buffer containing 0.03% Brij 35 where the peptide displayed 17 ± 1% α-helix; without the Brij 35, peptide-(419-436) displayed no helical content. The Kd for the peptide-(419-436) blocking CD4 binding to gp120 in Brij 35-containing buffer was found to be 42 µ. These results indicate that C4 constructs from HIV-1 and HIV-2 do bind CD4, but the constructs must display an α-helical conformation to do so. In addition, the results reported here will provide answers to key questions about structural requirements for HIV vaccines and therapeutics that hinge on understanding the molecular nature of the gp120-CD4 interaction as the first step in the HIV infection process. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002231&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell leukemia virus type I tax protein transactivates RNA polymerase III promoter in vitro and in vivo. AU - Piras, G. AU - Dittmer, J. AU - Radonovich, M. F. AU - Brady, J. N. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 34 SP - 20501 EP - 20506 SN - 0021-9258 AD - Piras, G.: Laboratory of Molecular Virology, NCI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001091. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Registry Number: 9014-24-8, 9026-28-2. KW - HTLV infections KW - human diseases KW - rna polymerase KW - tax protein KW - transactivation KW - transcription KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - DNA transcription KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - RNA nucleotidyltransferase KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Deficiency in β1,3-galactosyltransferase of a Leishmania major lipophosphoglycan mutant adversely influences the Leishmania-sand fly interaction. AU - Butcher, B. A. AU - Turco, S. J. AU - Hilty, B. A. AU - Pimenta, P. F. AU - Panunzio, M. AU - Sacks, D. L. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 34 SP - 20573 EP - 20579 SN - 0021-9258 AD - Butcher, B. A.: Laboratory of Parasitic Diseases, Intracellular Parasite Biology Section, National Institutes of Health, Bethesda, MD 28092, USA. N1 - Accession Number: 19970801100. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 128449-51-4. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases N2 - To study the function of side chain oligosaccharides of the cell-surface lipophosphoglycan (LPG), mutant Leishmania major defective in side chain biosynthesis were negatively selected by agglutination with the monoclonal antibody WIC79.3, which recognizes the galactose-containing side chains of L. major LPG. One such mutant (Spock) lacked the ability to bind significantly to midguts of the natural L. major vector, Phlebotomus papatasi, and to maintain infection in the sand fly after excretion of the digested blood meal. Biochemical characterization of Spock LPG revealed its structural similarity to the LPG of L. donovani, a species whose inability to bind to and maintain infections in P. papatasi midguts has been strongly correlated with the expression of a surface LPG lacking galactose-terminated oligosaccharide side chains. An in vitro galactosyltransferase assay using wild-type or Spock membranes was used to determine that the defect in Spock LPG biosynthesis is a result of defective β1,3-galactosyltransferase activity as opposed to a modification of LPG, which would prevent it from serving as a competent substrate for galactose addition. The results showed that Spock lacks the β1,3-galactosyltransferase for side chain addition and that the LPG side chains are required for L. major to bind to and to produce transmissible infection in P. papatasi. KW - biochemistry KW - carbohydrates KW - disease transmission KW - disease vectors KW - host parasite relationships KW - lipophosphoglycans KW - midgut KW - mutants KW - N-acetyllactosaminide 3-alpha-galactosyltransferase KW - oligosaccharides KW - parasites KW - Diptera KW - Leishmania donovani KW - Leishmania major KW - Phlebotominae KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - galactosyltransferase KW - parasite host relationships KW - saccharides KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease. AU - Saxena, S. K. AU - Gravell, M. AU - Wu YouNeng AU - Mikulski, S. M. AU - Shogen, K. AU - Ardelt, W. AU - Youle, R. J. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 34 SP - 20783 EP - 20788 SN - 0021-9258 AD - Saxena, S. K.: Biochemistry Section of the Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972001090. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 63231-63-0. N2 - Ribonucleases appear to have physiological roles in host defence against cancer, viruses, and other parasites. Previously it was shown that select ribonucleases added to cells concurrently with virions blocked HIV-1 infection of H9 cells. The authors now report that a ribonuclease homologous to RNase A, named onconase, inhibits virus replication in chronically HIV-1-infected human cells without killing the virally infected cell. Examining the mechanism of this inhibition shows that onconase enters the infected cells and degrades HIV-1 RNA without degrading ribosomal RNA or the three different cellular messenger RNAs analysed. The homologous human pancreatic RNase lacks antiviral activity. Comparing recombinant forms of onconase and a onconase-human RNase chimera shows that the N-terminal 9 amino acids and the pyroglutamyl residue of onconase are required for full antiviral activity. Thus extracellular ribonucleases can enter cells, metabolize select RNAs, and inhibit HIV virion production within viable replicating cells. KW - antiviral properties KW - degradation KW - enzymes KW - hiv-1 infections KW - human diseases KW - inhibition KW - production KW - replication KW - ribonucleases KW - rna KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - human immunodeficiency virus type 1 KW - onconase KW - ribonucleic acid KW - RNASE KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001090&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The catalytic domain of Acanthamoeba myosin I heavy chain kinase. I. Identification and characterization following tryptic cleavage of the native enzyme. AU - Brzeska, H. AU - Martin, B. M. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 43 SP - 27049 EP - 27055 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801970. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9026-43-1, 9002-07-7. Subject Subsets: Protozoology N2 - The actin-activated Mg2+-ATPase activities of the myosin I isoenzymes from Acanthamoeba castellanii are greatly increased by phosphorylation catalysed by myosin I heavy chain kinase (MIHC kinase), a monomeric 97-kDa protein whose activity is greatly enhanced by acidic phospholipids and by autophosphorylation of multiple sites. It was shown that the 35-kDa COOH-terminal fragment obtained by trypsin cleavage of maximally activated, autophosphorylated kinase retains the full activity and 2 to 3 of the autophosphorylation sites of the native enzyme. Other autophosphorylation sites occur in the middle third of the native enzyme. A trypsin cleavage site within the 35-kDa region is protected in phosphorylated kinase but is readily cleaved in unphosphorylated kinase producing catalytically inactive 25- and 11-kDa fragments from the NH2- and COOH-terminal ends, respectively, of the 35-kDa peptide. This implies that the conformation around the "25/11" cleavage site changes upon phosphorylation of the native enzyme. The position of this site corresponds to the activation loop of protein kinase A. Exogenously added MIHC kinase phosphorylates the 11-kDa fragment but not the 25-kDa fragment, indicating that the phosphorylation sites of the 35-kDa catalytic fragment are located within the COOH-terminal 11-kDa. The cloning, sequencing and expression of a fully active 35-kDa catalytic domain are described. KW - cleavage KW - enzymes KW - isoenzymes KW - kinases KW - molecular weight KW - myosins KW - parasites KW - peptides KW - phosphorylation KW - protein kinase KW - proteins KW - trypsin KW - Acanthamoeba castellanii KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - isozymes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801970&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The catalytic domain of Acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21-activated kinase (PAK). AU - Brzeska, H. AU - Szczepanowska, J. AU - Hoey, J. AU - Korn, E. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 43 SP - 27056 EP - 27062 SN - 0021-9258 AD - Brzeska, H.: Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801915. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9026-43-1. Subject Subsets: Protozoology N2 - Acanthamoeba castellanii myosin I heavy chain (MIHC) kinase is a monomeric 97-kDa protein that is activated by binding to acidic phospholipids or by autophosphorylation. Activation by phospholipids is inhibited by Ca2+-calmodulin. The cloning, sequencing and expression of the cDNA corresponding to the COOH-terminal 35 kDa catalytic domain of MIHC kinase are described. The expressed catalytic domain showed substrate specificity similar to that of native kinase and resistance to trypsin similar to that of fully phosphorylated MIHC kinase. The MIHC kinase catalytic domain had only 25% sequence identity to the catalytic domain of protein kinase A and similarly low sequence identity to the catalytic domains of protein kinase C- and calmodulin-dependent kinases, but 50% sequence identity and 70% similarity to the p21-activated kinase (PAK) and STE20 family of kinases. This suggests that MIHC kinase is evolutionarily related to the PAK family, whose activities are regulated by small GTP-binding proteins. The homology includes the presence of a potential MIHC kinase autophosphorylation site as well as conserved Tyr and Ser/Thr residues in the region corresponding to the P+1 loop of protein kinase A. A synthetic peptide corresponding to this region of MIHC kinase is phosphorylated by both the expressed catalytic domain and native MIHC kinase. [Nucleotide sequence data submitted to GenBank, accession number U67056]. KW - amino acid sequences KW - amino acids KW - complementary DNA KW - enzymes KW - evolution KW - gene expression KW - kinases KW - molecular genetics KW - myosins KW - parasites KW - protein kinase KW - proteins KW - synthetic peptides KW - Acanthamoeba castellanii KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cDNA KW - cloning KW - myosin KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801915&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site.. AU - Mazumder, A. AU - Neamati, N. AU - Pilon, A. A. AU - Sunder, S. AU - Pommier, Y. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 44 SP - 27330 EP - 27338 SN - 0021-9258 AD - Mazumder, A.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001022. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9007-49-2. N2 - An assay for monitoring the DNA binding of HIV-1 integrase and the effect of cofactors and inhibitors, is described. The assay uses depurinated oligonucleotides that can form a Schiff base between the aldehydic abasic site and a nearby enzyme lysine ε-amino group which can subsequently be trapped by reduction with sodium borohydride. Chemically depurinated duplex substrates representing the U5 end of the HIV-1 DNA were initially used. An enzymatically generated abasic site was substituted for each of 10 nucleotides normally present in a 21-mer duplex oligonucleotide representing the U5 end of the HIV-1 DNA. Using HIV-1, HIV-2 or SIV integrases, the amount of covalent enzyme-DNA complex trapped decreased as the abasic site was moved away from the conserved CA dinucleotide. The enzyme-DNA complexes formed in the presence of manganese were not reversed by subsequent addition of EDTA, indicating that the divalent metal required for integrase catalysis is tightly bound in a ternary enzyme-metal-DNA complex. Both the N- and C-terminal domains of integrase contributed to efficient DNA binding and mutation of Lys-136 significantly reduced Schiff base formation, implicating this residue in viral DNA binding. KW - DNA KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - integration KW - microbiology KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001022&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1. AU - Chun, R. F. AU - Jeang KuanTeh JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 44 SP - 27888 EP - 27894 SN - 0021-9258 AD - Chun, R. F.: Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972001008. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Registry Number: 63231-63-0, 9014-24-8, 9026-28-2. N2 - An α-amanitin-resistant system was used to study the role of the carboxyl-terminal domain (CTD) in the regulated transcription of HTLV-I and HIV-1, developed previously. Transcription directed by the HTLV-I activator protein Tax was strongly promoted by CTD-deficient RNA polymerase II. In contrast, the HIV-1 activator Tat, which is recruited to the promoter by tethering to a nascent leader RNA, required CTD-containing polymerase II for transcriptional activity. Biochemically, Tat associated with a cellular CTD kinase activity, whereas Tax did not. Concordantly, cellular transcription factor Sp1, which can activate CTD-deficient polymerase II with an efficiency similar to Tax, also failed to bind a CTD kinase. KW - hiv infections KW - human diseases KW - microbiology KW - promoters KW - RNA KW - rna polymerase KW - transcription KW - transcription factors KW - Deltaretrovirus KW - Human immunodeficiency virus 1 KW - human t-cell lymphotropic virus type i KW - retroviridae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - DNA transcription KW - genomic structure KW - HTLV-BLV group KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - promoter region KW - promoter sequences KW - ribonucleic acid KW - RNA nucleotidyltransferase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001008&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cysteine protease activated by expression of HIV-1 protease in transgenic mice. MIP26 (aquaporin-0) cleavage and cataract formation in vivo and ex vivo. AU - Mitton, K. P. AU - Kamiya, T. AU - Tumminia, S. J. AU - Russell, P. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1996/// VL - 271 IS - 50 SP - 31803 EP - 31806 SN - 0021-9258 AD - Mitton, K. P.: Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001390. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 52-90-4. N2 - Transgenic mice, homozygous for HIV-1 protease expression in the eye lens, display degradation of some lens crystallins and cytoskeletal proteins prior to cataract formation on postnatal days 23-25. Alterations to the internal lens hydration state also occur; therefore, the status of the aquaporin protein MIP26 was examined over postnatal days 16-25 to determine if it was altered during cataractogenesis. The MIP was identical in transgenic and control lenses until day 21. By postnatal day 25 (frank cataract), in the lenses obtained from transgenic animals, the 26-kDa band was absent and there was a concurrent increase in the proportion of MIP23. Immunoblotting demonstrated cleavage at the C terminus. Lenses were also maintained in an organ culture system to demonstrate that the cataractogenic process is inherent to the isolated lens and to determine the contribution of cysteine protease action. Organ culture experiments revealed a similar progression to nuclear cataract formation as seen in vivo. Two-dimensional gel analysis of the soluble lens crystallin fraction of organ cultured lenses revealed the same cleavage pattern as occurs in vivo. Organ culture of transgenic lenses with E64, a cysteine protease inhibitor, dramatically delayed cataractogenesis and prevented proteolytic cleavage of both MIP26 and crystallins. HIV-1 protease, while the trigger of cataract formation, does not appear to be the protease responsible for cleavage of MIP or lens crystallins. These results suggest that activation is involved in the cleavage of these proteins and occurs downstream of HIV-1 protease action. KW - antigens KW - cataract KW - cysteine KW - cysteine proteinases KW - eye diseases KW - eyes KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - microbiology KW - proteinases KW - proteins KW - proteolysis KW - structural genes KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunogens KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001390&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. AU - Yu Feng AU - Broder, C. C. AU - Kennedy, P. E. AU - Berger, E. A. JO - Science (Washington) JF - Science (Washington) Y1 - 1996/// VL - 272 IS - 5263 SP - 872 EP - 877 SN - 0036-8075 AD - Yu Feng: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19962009192. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - A cofactor for HIV-1 fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated "fusin", is a putative G protein-coupled receptor with 7 transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1-Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD+ human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T-cell-line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates [See also J. Cohen, pp. 809-810, for comment on the significance of this work.] KW - cd4 antigens KW - CD4+ lymphocytes KW - cell fusion KW - cofactors KW - HIV-1 infections KW - human diseases KW - macrophages KW - pathogenesis KW - receptors KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - CD4+ cells KW - fusin KW - human immunodeficiency virus type 1 KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009192&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. AU - Alkhatib, G. AU - Combadiere, C. AU - Broder, C. C. AU - Yu Feng AU - Kennedy, P. E. AU - Murphy, P. M. AU - Berger, E. A. JO - Science (Washington) JF - Science (Washington) Y1 - 1996/// VL - 272 IS - 5270 SP - 1955 EP - 1958 SN - 0036-8075 AD - Alkhatib, G.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. N1 - Accession Number: 19962008604. Publication Type: Journal Article. Language: English. Number of References: 32 ref. N2 - HIV-1 entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T-cell line-tropic isolates. The chemokines RANTES, MIP-1α, and MIP-1β, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains. KW - cell fusion KW - chemokines KW - cofactors KW - cytokines KW - HIV-1 infections KW - human diseases KW - macrophages KW - pathogenesis KW - phenotypes KW - receptors KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008604&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas. AU - Hinnebusch, B. J. AU - Perry, R. D. AU - Schwan, T. G. JO - Science (Washington) JF - Science (Washington) Y1 - 1996/// VL - 273 IS - 5273 SP - 367 EP - 370 SN - 0036-8075 AD - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19970500220. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - Biological transmission of plague depends on blockage of the foregut of the vector flea by a mass of plague bacilli. Blockage in Xenopsylla cheopis was found to be dependent on the haemin storage (hms) locus. Y. pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the hms locus markedly alters the course of Y. pestis infection in its insect vector, leading to a change in blood-feeding behaviour and to efficient transmission of plague. KW - disease transmission KW - disease vectors KW - feeding KW - foregut KW - genes KW - infection KW - infections KW - laboratory animals KW - midgut KW - mutants KW - transmission KW - mice KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - Xenopsylla KW - Pulicidae KW - Siphonaptera KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - haemin KW - hemin KW - Oriental rat flea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500220&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. AU - Dean, M. AU - Carrington, M. AU - Winkler, C. AU - Huttley, G. A. AU - Smith, M. W. AU - Allikmets, R. AU - Goedert, J. J. AU - Buchbinder, S. P. AU - Vittinghoff, E. AU - Gomperts, E. AU - Donfield, S. AU - Vlahov, D. AU - Kaslow, R. AU - Saah, A. AU - Rinaldo, C. AU - Detels, R. AU - O'Brien, S. J. JO - Science (Washington) JF - Science (Washington) Y1 - 1996/// VL - 273 IS - 5283 SP - 1856 EP - 1862 SN - 0036-8075 AD - Dean, M.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19962009453. Publication Type: Journal Article. Language: English. Number of References: 53 ref. KW - alleles KW - disease course KW - genes KW - genetics KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - structural genes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009453&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ocular manifestations of AIDS. AU - Whitcup, S. M. AU - Young, L. H. Y. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 275 IS - 2 SP - 142 EP - 144 SN - 0098-7484 AD - Whitcup, S. M.: National Eye Institute, 10 Center Dr. Building 10, Room 10N202, Bethesda, MD 20892-1858, USA. N1 - Accession Number: 19962001814. Publication Type: Journal Article. Language: English. Number of References: 26 ref. KW - acquired immune deficiency syndrome KW - clinical aspects KW - eye diseases KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - opportunistic infections KW - retinitis KW - treatment KW - cytomegalovirus KW - man KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001814&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluating new vaccines for developing countries: efficacy or effectiveness? AU - Clemens, J. AU - Brenner, R. AU - Rao, M. AU - Tafari, N. AU - Lowe, C. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 275 IS - 5 SP - 390 EP - 397 SN - 0098-7484 AD - Clemens, J.: Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 19962004457. Publication Type: Journal Article. Language: English. Number of References: 87 ref. Subject Subsets: Public Health N2 - In this article, the authors review the conventional sequence of clinical evaluations of new vaccines under consideration for developing countries and explain how the typical perspective of contemporary vaccine trials may obscure rather than enlighten rational decision making about the introduction of new vaccines in these settings. They also describe how these problems may be remedied by supplementing conventional trials with new types of trials designed to evaluate the practical costs and benefits of new vaccines. KW - human diseases KW - immunization KW - infectious diseases KW - reviews KW - Developing countries KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - countries KW - communicable diseases KW - immune sensitization KW - Third World KW - Underdeveloped Countries KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004457&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary protein and blood pressure. AU - Obarzanek, E. AU - Velletri, P. A. AU - Cutler, J. A. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 275 IS - 20 SP - 1598 EP - 1603 SN - 0098-7484 AD - Obarzanek, E.: National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, 2 Rockledge Centre, MSC 7936, 6701 Rockledge Dr. Room 8136, Bethesda, MD 20892-7936, USA. N1 - Accession Number: 19961407468. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Human Nutrition N2 - The relationship between dietary protein and blood pressure in man and animals is reviewed. KW - animal models KW - blood pressure KW - protein intake KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407468&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum HIV-1 RNA levels and time to development of AIDS in the multicenter hemophilia cohort study. AU - O'Brien, T. R. AU - Blattner, W. A. AU - Waters, D. AU - Eyster, M. E. AU - Hilgartner, M. W. AU - Cohen, A. R. AU - Luban, N. AU - Hatzakis, A. AU - Aledort, L. M. AU - Rosenberg, P. S. AU - Miley, W. J. AU - Kroner, B. L. AU - Goedert, J. J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 276 IS - 2 SP - 105 EP - 110 SN - 0098-7484 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA. N1 - Accession Number: 19962007626. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0. KW - disease course KW - haemophilia KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - prognosis KW - risk groups KW - RNA KW - seroconversion KW - serology KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - disease progression KW - hemophilia KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007626&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence of dementia in older Japanese-American men in Hawaii. The Honolulu-Asia aging study. AU - White, L. AU - Petrovitch, H. AU - Ross, W. AU - Masaki, K. H. AU - Abbott, R. D. AU - Teng, E. L. AU - Rodriguez, B. L. AU - Blanchette, P. L. AU - Havlik, R. J. AU - Wergowske, G. AU - Chiu, D. AU - Foley, D. J. AU - Murdaugh, C. AU - Curb, J. D. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 276 IS - 12 SP - 955 EP - 960 SN - 0098-7484 AD - White, L.: National Institute of Aging, Honolulu Heart Program, Honolulu-Asia Aging Study, 347 N Kuakini St, Honolulu, HI 96817, USA. N1 - Accession Number: 19962008508. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health; Tropical Diseases N2 - The Honolulu Heart Program is a prospective population-based study of cardiovascular disease established in 1965. Prevalence estimates were computed from cases identified at the 1991 to 1993 examination. Cognitive performance was assessed using standardized methods, instruments, and diagnostic criteria. Subjects were 3734 Japanese-American men (80% of surviving cohort) aged 71 through 93 years, living in the community or in institutions. Age-specific, age-standardized, and cohort prevalence estimates were computed for dementia (all cause) defined by 2 sets of diagnostic criteria and 4 levels of severity. Prevalence levels for Alzheimer's disease and vascular dementia were also estimated. Dementia prevalence ranged from 2.1% in men aged 71 through 74 years to 33.4% in men aged 85 through 93 years. Age-standardized prevalence was 7.6%. Prevalence estimates for the cohort were 9.3% for dementia (all cause), 5.4% for Alzheimer's disease (primary or contributing), and 4.2% for vascular dementia (primary or contributing). More than one possible cause was found in 26% of cases. The Alzheimer's disease/vascular dementia ratio was 1.5 for cases attributed primarily to Alzheimer's disease or vascular dementia. It is concluded that prevalence of Alzheimer's disease in older Japanese-American men in Hawaii appears to be higher than in Japan but similar to European-ancestry populations. Prevalence of vascular dementia appears to be only slightly lower than in Japan, but higher than in European-ancestry populations. Further cross-national research with emphasis on standardized diagnostic methods is needed. KW - alzheimer's disease KW - dementia KW - disease prevalence KW - elderly KW - human diseases KW - men KW - Hawaii KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Polynesia KW - Oceania KW - Pacific Islands KW - aged KW - elderly people KW - older adults KW - senior citizens KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008508&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines. AU - Robbins, J. B. AU - Schneerson, R. AU - Anderson, P. AU - Smith, D. H. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 276 IS - 14 SP - 1181 EP - 1185 SN - 0098-7484 AD - Robbins, J. B.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962009168. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Public Health KW - bacterial diseases KW - conjugate vaccines KW - disease prevention KW - human diseases KW - immunization KW - infections KW - meningitis KW - reviews KW - vaccination KW - vaccines KW - Haemophilus influenzae type b KW - man KW - Haemophilus influenzae KW - Haemophilus KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009168&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. AU - Quinn, T. C. AU - Gaydos, C. AU - Shepherd, M. AU - Bobo, L. AU - Hook, E. W., III AU - Viscidi, R. AU - Rompalo, A. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1996/// VL - 276 IS - 21 SP - 1737 EP - 1742 SN - 0098-7484 AD - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19972001684. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health N2 - The aim of this study in Maryland, USA, was to determine the frequency of Chlamydia trachomatis genital infection within sexual partnerships and to identify the variables that might modify transmission. 494 people in sexual partnerships attending sexually transmitted disease clinics in Baltimore were included. DNA sequencing was performed to examine specific genotypes within and between partnerships. Cross-sectional analysis was performed to determine characteristics associated with concordance or discordance of infection with partnerships. Cultures were positive for C. trachomatis in 8.5% of males and 12.9% of females (P = 0.03). Using PCR, more infections were identified both in males (14.2%) and in females (15.8%), and the difference in infection rates analysed by sex was no longer significant. In 20.4% of 494 couples, at least 1 partner had PCR results positive for C. trachomatis, with a concordant infection rate of 10.7%, significantly higher than the 5.5% concordant infection rate demonstrable by culture (P <0.01). Male-female and female-male transmission frequencies were equal (68%). The nucleotide sequences of the major outer membrane protein gene products were identical and unique for each of 15 culture-negative, PCR-positive concordant partnerships. In concordant infections, factors associated with infection in female partners were age <20 years, >1 partner in the past 6 months, and cervical ectopy >25%. Using PCR, the frequency of chlamydia transmission by infected males and females was nearly identical. The high rate of concordant infection, high frequency of infection among asymptomatic individuals, and high frequency of transmission regardless of sex underscore the importance of routine screening for chlamydia in both males and females, along with provision of treatment to all sexual partners of chlamydia-infected individuals. KW - bacterial diseases KW - disease prevalence KW - disease transmission KW - epidemiology KW - female genital diseases KW - genotypes KW - human diseases KW - infections KW - male genital diseases KW - sexual partners KW - Maryland KW - North America KW - USA KW - Chlamydia trachomatis KW - man KW - Chlamydia KW - Chlamydiaceae KW - Chlamydiales KW - Chlamydiae KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001684&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1. AU - Currens, M. J. AU - Gulakowski, R. J. AU - Mariner, J. M. AU - Moran, R. A. AU - Buckheit, R. W., Jr. AU - Gustafson, K. R. AU - McMahon, J. B. AU - Boyd, M. R. JO - Journal of Pharmacology and Experimental Therapeutics JF - Journal of Pharmacology and Experimental Therapeutics Y1 - 1996/// VL - 279 IS - 2 SP - 645 EP - 651 SN - 0022-3565 AD - Currens, M. J.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001198. Publication Type: Journal Article. Language: English. Number of References: 37 ref. KW - antiviral agents KW - antiviral properties KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - treatment KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - anti-viral properties KW - calanolides KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - non-nucleoside RT inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001198&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A. AU - Currens, M. J. AU - Mariner, J. M. AU - McMahon, J. B. AU - Boyd, M. R. JO - Journal of Pharmacology and Experimental Therapeutics JF - Journal of Pharmacology and Experimental Therapeutics Y1 - 1996/// VL - 279 IS - 2 SP - 652 EP - 661 SN - 0022-3565 AD - Currens, M. J.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001199. Publication Type: Journal Article. Language: English. Number of References: 29 ref. KW - antiviral agents KW - antiviral properties KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - treatment KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - anti-viral properties KW - calanolides KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - non-nucleoside RT inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001199&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Avian exposure and risk of lung cancer in women in Missouri: population based case-control study. AU - Alavanja, M. C. R. AU - Brownson, R. C. AU - Berger, E. AU - Lubin, J. AU - Modigh, C. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1996/// VL - 313 IS - 7067 SP - 1233 EP - 1235 SN - 0959-8138 AD - Alavanja, M. C. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19972009228. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health N2 - To investigate the association between ownership of pet birds and the risk of lung cancer, a population based case-control study was conducted in the USA with a structured questionnaire administered by telephone. All newly diagnosed female primary lung cancer cases aged 30-84 years in Missouri, reported to the state cancer registry during 1 January 1993-31 January 1994, were invited to participate (n=652) together with 629 population-based controls. Odds ratios were computed in relation to whether or not the study subject ever kept pet birds, the type of bird kept, and several measures of intensity or duration of exposure. Odds ratios were adjusted for smoking. The odds ratio (95% confidence interval) for the development of lung cancer associated with keeping pet birds was 0.84 (0.65 to 1.09). The results were similar for the type of pet bird kept, the number of birds kept, the location of the bird in the house, and the duration of ownership. It is concluded that the keeping of pet birds carries no excess risk for the development of lung cancer. KW - aetiology KW - aviary birds KW - human diseases KW - lung cancer KW - lungs KW - neoplasms KW - pets KW - risk factors KW - women KW - Missouri KW - North America KW - USA KW - birds KW - man KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cage birds KW - cancer sites KW - cancers KW - causal agents KW - etiology KW - pet animals KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin. AU - Omatsu-Kanbe, M. AU - Zarnowski, M. J. AU - Cushman, S. W. JO - Biochemical Journal (London) JF - Biochemical Journal (London) Y1 - 1996/// VL - 315 IS - 1 SP - 25 EP - 31 SN - 0264-6021 AD - Omatsu-Kanbe, M.: Experimental Diabetes, Metabolism and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19961407443. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 58-61-7, 50-99-7, 9004-10-8, 299-95-6, 51-30-9, 6700-39-6, 76853-59-2. Subject Subsets: Human Nutrition N2 - Isolated brown adipose cells from male Sprague-Dawley rats were prepared whose viability was indicated by the expected stimulation of oxygen consumption by noradrenaline and counter-regulation of this oxygen consumption response by insulin. Insulin stimulates 3-O-methyl-D-glucose transport by about 15-fold in the absence of adenosine, and adenosine augments this response at least 2-fold. The insulin-stimulated translocation of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane is readily detected by subcellular fractionation and Western blotting, and the appearance of GLUT4 on the cell surface in response to insulin is demonstrated by bis-mannose photolabelling. Isoprenaline also stimulates glucose transport activity but only by about 3-fold; this effect is not altered by adenosine. Isoprenaline increases insulin-stimulated glucose transport activity in the absence of adenosine but decreases it in the presence of adenosine. These results demonstrate that although the regulation of glucose transport by insulin in brown adipose cells is qualitatively similar to that in white adipose cells, counter-regulation by adenosine and isoprenaline is at least quantitatively and may be qualitatively different. Isolated brown adipose cells from rats thus represent an excellent model for further examination of the mechanism by which multiple hormone signalling pathways interact to control glucose transport and GLUT4 subcellular trafficking. KW - adenosine KW - brown fat KW - glucose KW - insulin KW - isoprenaline KW - transport KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - dextrose KW - isoproterenol KW - transportation KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407443&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene expression of iron-related proteins during iron deficiency caused by scurvy in guinea pigs. AU - Gosiewska, A. AU - Mahmoodian, F. AU - Peterkofsky, B. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1996/// VL - 325 IS - 2 SP - 295 EP - 303 SN - 0003-9861 AD - Gosiewska, A.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19971401658. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 50-81-7, 9007-73-2, 7439-89-6, 11096-37-0. Subject Subsets: Human Nutrition N2 - The study aimed to find out at what stage of scurvy iron deficiency occurred and whether changes in expression of iron-related proteins during scurvy resulted directly from iron depletion or from systemic changes associated with weight loss. Guinea pigs were fed on an ascorbic acid-free diet and controls were given a 25 mg/100 g body weight ascorbic acid supplement. Serum iron decreased to 75-54% of normal during the first phase of ascorbic acid deficiency (ascorbic acid depletion, no weight loss, 0-21 days) and then decreased further in the second phase when weight loss began to occur (21-30 days). Unsaturated iron binding capacity increased to almost 4 times normal by 30 days of ascorbic acid-free diet. Ferritin L subunit concentrations decreased while H subunit was still detectable and transferrin concentrations increased on ascorbic acid-free diet. Hepatic cytosolic aconitase activity decreased to about 43% of normal in the first phase of scurvy and decreased further when weight-loss occurred, to about 28% of normal. Hepatic RNA concentrations were measured for transferrin (Tf), ferritin L subunit (FL), ferritin H subunit (FH), iron regulatory protein 1 (IRP-1) and transferrin receptor protein (TfR). TfR concentrations increased after only 7 days of ascorbic acid deficiency and continued to increase to about 5 times normal. IRP-1, FL and Tf RNAs decreased significantly even before weight loss occurred. FH RNA was not decreased significantly until the guinea pigs had lost 24-28% body weight. In conclusion vitamin C depletion leads to iron deficiency in guinea pigs which begins before weight loss occurs and leads to iron related gene expression changes which do not involve insulin-like growth factor-binding protein. KW - ascorbic acid KW - blood KW - deficiency KW - ferritin KW - gene expression KW - iron KW - metabolism KW - receptors KW - regulation KW - scurvy KW - trace elements KW - transferrin KW - vitamin deficiencies KW - vitamins KW - guineapigs KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - guinea pigs KW - microelements KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401658&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bacterial pneumonia in HIV. AU - Cohen, J. I. AU - Hirschtick, R. E.\Glassroth, J.\Jordan, M. C. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 334 IS - 3 SP - 195 EP - 195 SN - 0028-4793 AD - Cohen, J. I.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19962002048. Publication Type: Journal Article. Language: English. Number of References: 3 ref. KW - acquired immune deficiency syndrome KW - bacterial diseases KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunization KW - pneumonia KW - vaccines KW - man KW - Streptococcus pneumoniae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Streptococcus KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - AIDS KW - bacterial infections KW - bacterioses KW - bacterium KW - clinical picture KW - Haemophilus influenza KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962002048&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. AU - Stanley, S. K. AU - Ostrowski, M. A. AU - Justement, J. S. AU - Gantt, K. AU - Hedayati, S. AU - Mannix, M. AU - Roche, K. AU - Schwartzentruber, D. J. AU - Fox, C. H. AU - Fauci, A. S. AU - Greene, W. C. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 334 IS - 19 SP - 1222 EP - 1230 SN - 0028-4793 AD - Stanley, S. K.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg. 30, Rm. 7A03, 31 Center Dr., MSC-2520, Bethesda, MD 20892-2520, USA. N1 - Accession Number: 19962009187. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - [See also W. C. Greene, pp. 1264-65.] KW - antigens KW - HIV-1 infections KW - human diseases KW - immune response KW - immunization KW - immunopathology KW - pathogenesis KW - tetanus toxoid KW - viraemia KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - immunopathogenesis KW - recall antigens KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009187&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The cloning and clinical implications of HGV and HGBV-C. AU - Alter, H. J. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 334 IS - 23 SP - 1536 EP - 1537 SN - 0028-4793 AD - Alter, H. J.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962005881. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health N2 - This editorial discusses the nomenclature of viral hepatitis agents and the identification, epidemiology and pathology of the newly identified hepatitis G virus and hepatitis GB virus C. KW - aetiology KW - clinical aspects KW - editorials KW - epidemiology KW - human diseases KW - identification KW - viral diseases KW - hepatitis G virus KW - man KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - causal agents KW - clinical picture KW - cloning KW - etiology KW - hepatitis GB virus C KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005881&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis C virus-associated fulminant hepatic failure. AU - Farci, P. AU - Alter, H. J. AU - Shimoda, A. AU - Govindarajan, S. AU - Cheung, L. C. AU - Melpolder, J. C. AU - Sacher, R. A. AU - Shih, J. W. AU - Purcell, R. H. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 335 IS - 9 SP - 631 EP - 634 SN - 0028-4793 AD - Farci, P.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19962008057. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health N2 - In this report, a patient in the USA with HCV-associated fulminant hepatitis is described in whom serial studies were done that provided a unique opportunity to establish a temporal association between the acquisition of HCV infection and the development of fulminant hepatitis and to define the clinical, virological, and histological profile of fulminant hepatitis C. KW - case reports KW - clinical aspects KW - diagnosis KW - hepatitis C KW - human diseases KW - liver failure KW - District of Columbia KW - North America KW - USA KW - hepatitis C virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008057&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Zidovudine alone or in combination with didanosine or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter. AU - Saravolatz, L. D. AU - Winslow, D. L. AU - Collins, G. AU - Hodges, J. S. AU - Pettinelli, C. AU - Stein, D. S. AU - Markowitz, N. AU - Reves, R. AU - Loveless, M. O. AU - Crane, L. AU - Thompson, M. AU - Abrams, D. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 335 IS - 15 SP - 1099 EP - 1106 SN - 0028-4793 AD - Saravolatz, L. D.: Correspondence address: Dr L. Deyton, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962009080. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 69655-05-6, 7841-89-2, 30516-87-1. KW - adverse effects KW - clinical trials KW - combination therapy KW - didanosine KW - dideoxycytidine KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - zidovudine KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - AZT KW - chemotherapy KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - multimodal treatment KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009080&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. AU - Kovacs, J. A. AU - Vogel, S. AU - Albert, J. M. AU - Falloon, J. AU - Davey, R. T., Jr. AU - Walker, R. E. AU - Polis, M. A. AU - Spooner, K. AU - Metcalf, J. A. AU - Baseler, M. AU - Fyfe, G. AU - Lane, H. C. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1996/// VL - 335 IS - 18 SP - 1350 EP - 1356 SN - 0028-4793 AD - Kovacs, J. A.: Critical Care Medicine Department, Clinical Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19972000217. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - A controlled study to evaluate the long-term effects of intermitten transfusions of interleukin-2 on both CD4+ counts and viral burden in 60 HIV-infected patients from the USA, is reported. In patients treated with interleukin-2, the mean CD4+ KW - adverse effects KW - antiviral agents KW - clinical trials KW - cytokines KW - drug therapy KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunomodulators KW - immunotherapy KW - interleukins KW - t lymphocytes KW - treatment KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000217&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation and properties of bone alkaline phosphatase during vitamin C deficiency in Guinea pigs. AU - Mahmoodian, F. AU - Gosiewska, A. AU - Peterkofsky, B. JO - Archives of Biochemistry and Biophysics JF - Archives of Biochemistry and Biophysics Y1 - 1996/// VL - 336 IS - 1 SP - 86 EP - 96 SN - 0003-9861 AD - Mahmoodian, F.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19981403748. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9001-78-9, 50-81-7, 104982-03-8. Subject Subsets: Human Nutrition KW - alkaline phosphatase KW - ascorbic acid KW - bones KW - collagen KW - deficiency KW - gene expression KW - osteocalcin KW - regulation KW - scurvy KW - vitamins KW - guineapigs KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - alkaline phosphomonoesterase KW - guinea pigs KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403748&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Autoimmunity and onchocerciasis. AU - Cooper, P. J. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1996/// VL - 347 IS - 8998 SP - 404 EP - 404 SN - 0140-6736 AD - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19960803993. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - So-called autoimmunity in Onchocerca volvulus infections is considered to be related to a widespread non-specific activation of the immune system due to massive antigen load, rather than to an immunopathogenic mechanism. KW - antigens KW - autoimmune diseases KW - autoimmunity KW - helminths KW - human diseases KW - immunological diseases KW - immunology KW - immunopathology KW - onchocerciasis KW - parasites KW - man KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - immunogens KW - immunopathogenesis KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803993&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Perinatal intervention trial in Africa: effect of a birth canal cleansing intervention to prevent HIV transmission. AU - Biggar, R. J. AU - Miotti, P. G. AU - Taha, T. E. AU - Mtimavalye, L. AU - Broadhead, R. AU - Justesen, A. AU - Yellin, F. AU - Liomba, G. AU - Miley, W. AU - Waters, D. AU - Chiphangwi, J. D. AU - Goedert, J. J. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1996/// VL - 347 IS - 9016 SP - 1647 EP - 1650 SN - 0140-6736 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19962007232. Publication Type: Journal Article. Language: English. Number of References: 29 ref. KW - disease prevention KW - disease transmission KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - maternal transmission KW - pregnancy KW - women KW - Malawi KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - mother to child transmission KW - Nyasaland KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007232&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Global burden of the HIV pandemic. AU - Quinn, T. C. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1996/// VL - 348 IS - 9020 SP - 99 EP - 106 SN - 0140-6736 AD - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, Johns Hopkins University, Baltimore, MD 21205-2196, USA. N1 - Accession Number: 19962007087. Publication Type: Journal Article. Language: English. Number of References: 50 ref. KW - disease transmission KW - epidemics KW - epidemiology KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007087&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changing the natural history of HIV disease. AU - Feinberg, M. B. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1996/// VL - 348 IS - 9022 SP - 239 EP - 246 SN - 0140-6736 AD - Feinberg, M. B.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19962007653. Publication Type: Journal Article. Language: English. Number of References: 48 ref. KW - clinical aspects KW - disease course KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - pathogenesis KW - serology KW - survival KW - t lymphocytes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - clinical picture KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007653&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned. AU - Schneerson, R. AU - Robbins, J. B. AU - Taranger, J. AU - Lagergård, T. AU - Trollfors, B. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1996/// VL - 348 IS - 9037 SP - 1289 EP - 1292 SN - 0140-6736 AD - Schneerson, R.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, NIH, Room 424, Building 6, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003629. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health N2 - Vaccines for pertussis and diphtheria are reviewed with emphasis on the development and efficacy of toxoid vaccines. KW - acellular vaccines KW - bacterial diseases KW - bacterial toxins KW - diphtheria KW - efficacy KW - human diseases KW - immunity KW - immunization KW - inactivated vaccines KW - pertussis KW - reviews KW - vaccination KW - vaccine development KW - vaccines KW - bordetella pertussis KW - corynebacterium diphtheriae KW - man KW - Bordetella KW - Alcaligenaceae KW - Burkholderiales KW - Betaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Corynebacterium KW - Corynebacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - immune sensitization KW - killed vaccines KW - whooping cough KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003629&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. AU - Wachsman, J. T. JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis Y1 - 1996/// VL - 350 IS - 1 SP - 25 EP - 34 SN - 0027-5107 AD - Wachsman, J. T.: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19961410515. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 75 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition N2 - This article is an expanded version of a talk given at the 4th International Conference on Antimutagenesis and Anticarcinogenesis, September 4-9, 1994, Banff, Alberta, Canada. Studies that have examined the effects of dietary restriction on oxidative damage and apoptosis are reviewed and the beneficial effect of these on aging and carcinogenesis are also discussed. KW - aging KW - animal models KW - apoptosis KW - carcinogenesis KW - damage KW - DNA KW - food restriction KW - free radicals KW - lipid peroxidation KW - mitochondria KW - mutagenesis KW - oxidation KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - deoxyribonucleic acid KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410515&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protective selective pressure. AU - Miller, L. H. JO - Nature (London) JF - Nature (London) Y1 - 1996/// VL - 383 IS - 6600 SP - 480 EP - 481 SN - 0028-0836 AD - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970800547. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - The finding of T.N. Williams et al. [Nature (1996) 383 (6600), 522-525] that on the island of Espiritu Santo in Vanuatu, there was an increased incidence of malaria in children who were homozygous for α+-thalassaemia is discussed. This is interpreted by the authors as being evidence for a protective effect of α+-thalassaemia against dying from malaria. They suggest that protection may result from an increased incidence of mild malaria in early childhood, which generates increased immunity and reduces the likelihood of a subsequent life-threatening severe attack. KW - alpha-thalassaemia KW - children KW - epidemiology KW - human diseases KW - malaria KW - parasites KW - resistance KW - selection pressure KW - thalassaemia KW - Australasia KW - Vanuatu KW - man KW - Plasmodium KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Oceania KW - ACP Countries KW - Commonwealth of Nations KW - Least Developed Countries KW - Developing Countries KW - Melanesia KW - Australasia KW - Pacific Islands KW - alpha-thalassemia KW - New Hebrides KW - thalassemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Host factors and the pathogenesis of HIV-induced disease. AU - Fauci, A. S. JO - Nature (London) JF - Nature (London) Y1 - 1996/// VL - 384 IS - 6609 SP - 529 EP - 534 SN - 0028-0836 AD - Fauci, A. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001213. Publication Type: Journal Article. Language: English. Number of References: 113 ref. N2 - The role of host factors in the pathogenesis of HIV-induced disease is reviewed, particularly cellular activation and the role of cytokines and their receptors in regulating viral replication and in pathogenesis. Exogenous factors and HIV replication, endogenous cytokines, suppression of HIV replication, viral co-receptors and cellular tropisms, co-receptors and resistance to infection, progression of HIV-induced disease and therapeutic and preventive strategies are discussed. KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - immunopathology KW - pathogenesis KW - reviews KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gliosis in the LP-BM5 murine leukemia virus infected mouse: an animal model of retrovirus-induced dementia. AU - Kustova, Y. AU - Sei, Y. AU - Goping, G. AU - Basile, A. S. JO - Brain Research JF - Brain Research Y1 - 1996/// VL - 742 IS - 1/2 SP - 271 EP - 282 SN - 0006-8993 AD - Kustova, Y.: Laboratory of Neuroscience, Bldg 8, Rm 111, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972002941. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - Mice infected with the LP-BM5 murine leukaemia virus (MuLV) mixture develop severe immunosuppression, neurotransmitter abnormalities and cognitive impairments in the absence of significant viral or macrophage invasion of the CNS. The time-course of the changes in glial activation have been characterized in an effort to understand the cellular basis of the neurobehavioural abnormalities observed in these mice. Glial activation was determined by measuring the relative changes in F4/80 protein and GFAP immunoreactivity using immunoblots. Augmented F4/80 expression preceded that of GFAP, with global elevations of 4-6 fold at 3 weeks, sustained for up to 12 weeks after inoculation. GFAP immunoreactivity increased 2-fold only in the cerebral cortex and striatum 5 weeks postinfection, declining to control levels by 12 weeks. Immunohistochemistry revealed significant increases in microglial size and staining intensity in the cortex, corpus callosum and striatum, with the development of a unique population of highly ramified, intensely stained microglia and microglial nodules in the corpus callosum and striatum. KW - abnormalities KW - acquired immune deficiency syndrome KW - animal models KW - brain KW - dementia KW - HIV-1 infections KW - human diseases KW - immunohistochemistry KW - leukaemia KW - macrophages KW - neuroglia KW - nodules KW - pathology KW - Human immunodeficiency virus 1 KW - mice KW - Murine leukemia virus KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - AIDS KW - blood cancer KW - cerebrum KW - glial cells KW - human immunodeficiency virus type 1 KW - leucaemia KW - leukemia KW - murine leukaemia virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002941&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Production of a malaria transmission-blocking protein from recombinant yeast. AU - Wang, M. Y. AU - Kaslow, D. C. AU - Shiloach, J. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1996/// VL - 782 SP - 123 EP - 132 SN - 0077-8923 AD - Wang, M. Y.: Biotechnology Unit NIDDK Molecular Vaccine Section NISID National Institutes of Health Bethesda, MD 20892, USA. N1 - Accession Number: 19980801996. Publication Type: Journal Article. Language: English. Number of References: 16 ref. KW - human diseases KW - malaria KW - recombinant proteins KW - transmission blocking immunity KW - vaccine development KW - yeasts KW - man KW - Plasmodium KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801996&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human papillomavirus immunology and vaccine prospects. AU - Steller, M. A. AU - Schiller, J. T. JO - Journal of the National Cancer Institute Monographs JF - Journal of the National Cancer Institute Monographs Y1 - 1996/// IS - 21 SP - 145 EP - 148 AD - Steller, M. A.: National Institutes of Health, Bethesda, MD 20892-1502, USA. N1 - Accession Number: 19982000023. Publication Type: Journal Article. Language: English. Number of References: 28 ref. N2 - Therapeutic and prophylactic vaccines in the prevention of human papillomavirus (HPV) infections and HPV-related cervical cancer are discussed. KW - cervical cancer KW - human diseases KW - immunization KW - infections KW - neoplasms KW - vaccines KW - viral diseases KW - women KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Papillomaviridae KW - cancers KW - human papillomavirus KW - immune sensitization KW - Papovaviridae KW - viral infections KW - Non-communicable Human Diseases and Injuries (VV600) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000023&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Biology and tropism of human immunodeficiency virus-1 in the nervous system. AU - Conant, K. E. AU - Monaco, M. G. AU - Major, E. O. A2 - Berger, J. R. A2 - Levy, R. M. T2 - AIDS and the nervous system. JO - AIDS and the nervous system. JF - AIDS and the nervous system. Y1 - 1996/// IS - Ed. 2 SP - 39 EP - 57 CY - Philadelphia; USA PB - Lippincott-Raven Publishers SN - 0781703093 AD - Conant, K. E.: Laboratory of Molecular Medicine and Neuroscience, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972007313. Publication Type: Miscellaneous. Language: English. Number of References: 171 refs. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - nervous system diseases KW - pathogenesis KW - tropisms KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - neuropathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Food allergy in adults. AU - Metcalfe, D. D. A2 - Metcalfe, D. D. A2 - Sampson, H. A. A2 - Simon, R. A. T2 - Food allergy: adverse reactions to food and food additives. Y1 - 1996/// IS - Ed. 2 CY - Cambridge; USA PB - Blackwell Science Inc. SN - 0865424322 AD - Metcalfe, D. D.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19971407184. Publication Type: Book chapter. Language: English. Number of References: 67 ref. Registry Number: 308067-57-4. Subject Subsets: Human Nutrition; Soyabeans N2 - The prevalence of food hypersensitivity reactions in adults and the pathogenesis of immunoglobulin E (IgE)-mediated hypersensitivity reactions are reviewed. Common allergenic foods including groundnuts, soyabeans, shrimps, fish and eggs are identified. Clinical patterns of target organ responses, in vivo and in vitro and oral challenge diagnostic tests and the management of food allergy are discussed. The characteristics and treatment of allergic eosinophilic gastroenteritis, gluten-sensitive enteropathy (coeliac disease) and dermatitis herpetiformis are described. KW - adults KW - allergens KW - coeliac syndrome KW - diagnosis KW - eggs KW - fish KW - food allergies KW - gastrointestinal diseases KW - groundnuts KW - hypersensitivity KW - immunoglobulins KW - shrimps KW - soyabeans KW - Arachis hypogaea KW - Glycine (Fabaceae) KW - man KW - Decapoda KW - Malacostraca KW - Crustacea KW - arthropods KW - invertebrates KW - animals KW - aquatic animals KW - aquatic organisms KW - eukaryotes KW - Arachis KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - allergic responses KW - celiac disease KW - celiac syndrome KW - coeliac disease KW - food hypersensitivity KW - gamma-globulins KW - gluten allergy KW - hypersensitiveness KW - immune globulins KW - peanuts KW - soybeans KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Crop Produce (QQ050) KW - Aquatic Produce (QQ060) KW - Eggs and Egg Products (QQ040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407184&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Food allergy: adverse reactions to food and food additives. A2 - Metcalfe, D. D. A2 - Sampson, H. A. A2 - Simon, R. A. T2 - Food allergy: adverse reactions to food and food additives. Y1 - 1996/// IS - Ed. 2 CY - Cambridge; USA PB - Blackwell Science Inc. SN - 0865424322 AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19971407100. Publication Type: Book. Language: English. Number of References: many ref. Registry Number: 308067-57-4, 142-47-2. Subject Subsets: Human Nutrition N2 - This book on food allergy is divided into 4 parts: the basic science of adverse reactions to food antigens; the clinical science of adverse reactions to food antigens; adverse reactions to food additives; and contemporary topics in adverse reactions to foods. Individual chapters address: mucosal immunity; mast cells, basophils and immunoglobulin E; food antigens; food biotechnology and genetic engineering; antigen absorption; oral tolerance: immune responses to food antigens; in vitro diagnostic methods in the evaluation of food hypersensitivity; skin testing and oral challenge procedures; immediate reactions to foods in infants and children; food allergy in adults; eczema and food hypersensitivity; food-induced urticaria; oral allergy syndrome; the respiratory tract and food hypersensitivity; anaphylaxis and food allergy; infantile colic and food hypersensitivity; eosinophilic gastroenteritis; food protein-induced colitis and gastroenteropathy in children; gluten-sensitive enteropathy (coeliac disease); exercise- and pressure-induced syndromes; occupational reactions to food allergens; adverse reactions to sulfites; monosodium glutamate; tartrate, azo and nonazo dyes; adverse reactions to benzoates and parabens; adverse reactions to the antioxidants butylated hydroxyanisole and butylated hydroxytoluene; urticaria, angioedemia, and anaphylaxis provoked by food additives; asthma and food additives; phamacological food reactions; management of food allergy; natural history and prevention of food hypersensitivity; diets and nutrition; food toxicology; neurological reactions to foods and food additives; behaviour and adverse food reactions; psychological considerations of food allergy; connective tissue reactions to foods; and unproved diagnostic and therapeutic techniques. Summaries of individual chapters are presented elsewhere in this issue of NAR/A. KW - adults KW - anaphylaxis KW - antigens KW - asthma KW - biotechnology KW - blood cells KW - children KW - coeliac syndrome KW - colic KW - diagnosis KW - diet KW - eczema KW - food additives KW - food allergies KW - food colourants KW - gastrointestinal diseases KW - genetic engineering KW - hypersensitivity KW - immune response KW - immunoglobulins KW - infants KW - monosodium glutamate KW - mucosa KW - occupations KW - psychology KW - sulfites KW - toxic substances KW - urticaria KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - allergic responses KW - anaphylactic reactions KW - anaphylactic shock KW - antigenicity KW - celiac disease KW - celiac syndrome KW - coeliac disease KW - food colorants KW - food hypersensitivity KW - gamma-globulins KW - genetic manipulation KW - gluten allergy KW - hypersensitiveness KW - immune globulins KW - immunity reactions KW - immunogens KW - immunological reactions KW - mucous membrane KW - nettle rash KW - poisons KW - psychological factors KW - sulphites KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Insect-transmitted pathogens in the insect midgut. AU - Kaslow, D. C. AU - Welburn, S. A2 - Lehane, M. J. A2 - Billingsley, P. F. T2 - Biology of the insect midgut. JO - Biology of the insect midgut. JF - Biology of the insect midgut. Y1 - 1996/// SP - 432 EP - 462 CY - London; UK PB - Chapman & Hall Ltd SN - 041261670X AD - Kaslow, D. C.: Malaria Vaccines Section, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980501272. Publication Type: Miscellaneous. Language: English. Number of References: 8 pp. of ref. Subject Subsets: Medical & Veterinary Entomology N2 - This review focuses on the transitions that occur when a pathogen establishes itself in an invertebrate vector. Some vector genetic and/or susceptibility factors that contribute to the establishment of midgut infections are also reviewed. Protozoans, filariae, arboviruses and bacteria are considered in different sections. KW - arboviruses KW - development KW - disease vectors KW - haematophagous insects KW - host parasite relationships KW - infections KW - midgut KW - pathogens KW - reviews KW - bacteria KW - Leishmania KW - Nematoda KW - Plasmodium KW - Protozoa KW - Trypanosoma KW - prokaryotes KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - arthropod-borne viruses KW - bacterium KW - bloodsucking insects KW - filariae KW - hematophagous insects KW - nematodes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501272&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Transmission-blocking vaccines. AU - Kaslow, D. C. A2 - Hoffman, S. L. T2 - Malaria vaccine development: a multi-immune response approach. Y1 - 1996/// CY - Washington; USA PB - American Society for Microbiology (ASM) SN - 1555811116 AD - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970801980. Publication Type: Book chapter. Language: English. Number of References: 106 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - This chapter covers: biology of the sexual stages of the malaria parasite; development of transmission-blocking vaccines; immune responses to sexual-stage antigens in humans (antigenic diversity, boosting after natural infection, immunogenicity to prefertilization target antigens); progress towards developing vaccines against specific antigens (mechanisms of antibody-dependent protective immune responses, current status of efforts to design, produce and evaluate vaccines to induce antibodies to target antigens in experimental model systems, current status of efforts to design, produce and evaluate vaccines to induce antibodies to target antigens in humans, current status of field trials of transmission-blocking vaccines). KW - human diseases KW - malaria KW - parasites KW - reviews KW - transmission blocking immunity KW - vaccine development KW - vaccines KW - Plasmodium KW - protozoa KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - transmission blocking vaccines KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801980&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Racial/ethnic patterns of cancer in the United States, 1988-1992. AU - Miller, B. A. AU - Kolonel, L. N. AU - Bernstein, L. AU - Young, J. L., Jr. AU - Swanson, G. M. AU - West, D. AU - Key, C. R. AU - Liff, J. M. AU - Glover, C. S. AU - Alexander, G. A. A2 - Miller, B. A. A2 - Kolonel, L. N. A2 - Bernstein, L. A2 - Young, J. L., Jr. A2 - Swanson, G. M. A2 - West, D. A2 - Key, C. R. A2 - Liff, J. M. A2 - Glover, C. S. A2 - Alexander, G. A. T2 - Racial/ethnic patterns of cancer in the United States, 1988-1992 T3 - NIH Pub. No. 96-4104 Y1 - 1996/// CY - Bethesda; USA PB - National Cancer Institute (NCI) AD - Miller, B. A.: Surveillance Research Program, Division of Cancer and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 20083240998. Publication Type: Book. Note: NIH Pub. No. 96-4104 Language: English. Subject Subsets: Public Health N2 - This monograph provides a description of the occurrence of the major cancers among several different racial/ethnic groups in the USA. Age-adjusted incidence rates are shown graphically by age group and sex for Alaska Native, American Indian (New Mexico), black, Chinese, Filipino, Hawaiian, Hispanic, Japanese, Korean, Vietnamese, white (total), white Hispanic and white non-Hispanic populations. Age-adjusted mortality rates are also shown for these groups, with the exception of Koreans and Vietnamese, for whom national data are not yet available. Incidence rates are provided by the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute and are based on newly diagnosed cancers between 1988 and 1992 for a subset of the United States population. Mortality rates are provided by the National Center for Health Statistics and are based on cancer deaths between 1988 and 1992 for the entire United States population. The cancers included in this report are organized alphabetically. They are followed by a section on cancer control efforts in special population groups and an appendix. The appendix contains tables showing the number of newly diagnosed cancers, by racial/ethnic group, in specific regions of the USA during 1988-1992. It also includes estimates for the entire country of the number of newly diagnosed cancers and the number of cancer deaths in 1990. The intent of this publication is to promote a greater understanding of the cancer problem in the United States, to identify those who can benefit most by education on the potential risks and consequences of certain behaviours and exposures, and to indicate areas where more knowledge and scientific investigation are needed to understand why cancer occurs more frequently in some groups of people than others. KW - African Americans KW - Asians KW - blacks KW - disease incidence KW - epidemiology KW - ethnic groups KW - ethnicity KW - Hispanics KW - human diseases KW - immigrants KW - neoplasms KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - ethnic differences KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Demography (UU200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083240998&site=ehost-live&scope=site UR - http://seer.cancer.gov/publications/ethnicity/ DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Initiation and regulation of CD4+ T-cell function in host-parasite models. AU - Jankovic, D. AU - Sher, A. A2 - Romagnani, S. T2 - Th1 and Th2 cells in health and disease. Y1 - 1996/// CY - Basel; Switzerland PB - S Karger AG SN - 3805562411 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19960804253. Publication Type: Book chapter. Language: English. Number of References: 67 ref. Subject Subsets: Helminthology; Protozoology N2 - This review concentrates on 2 parasites which represent different extremes (Toxoplasma gondii which induces strong type 1 cytokine responses, and Schistosoma mansoni which is associated predominantly with a type 2 cytokine production pattern). Aspects discussed include: cellular basis of polarized cytokine expression in parasitic infections; maintenance of polarized responses in established infection; mechanisms underlying the initiation of polarized responses in different parasitic infections. KW - CD4+ lymphocytes KW - cytokines KW - helminths KW - immune response KW - parasites KW - reviews KW - protozoa KW - Schistosoma mansoni KW - Toxoplasma gondii KW - invertebrates KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - CD4+ cells KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - t helper cells KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804253&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Anopheline mosquitoes and the agents they transmit. AU - Gwadz, R. AU - Collins, F. H. A2 - Beaty, B. J. A2 - Marquardt, W. C. T2 - The biology of disease vectors. Y1 - 1996/// CY - Niwot, CO; USA PB - University Press of Colorado SN - 0870814117 AD - Gwadz, R.: Laboratory of Malaria Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. N1 - Accession Number: 19970501078. Publication Type: Book chapter. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology KW - control KW - disease transmission KW - disease vectors KW - host parasite relationships KW - life cycle KW - mosquito-borne diseases KW - parasites KW - Anopheles KW - Culicidae KW - Diptera KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501078&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Yeast infections in the immunocompromised host. AU - Walsh, T. J. A2 - Howard, D. H. A2 - Miller, J. D. T2 - The Mycota. A comprehensive treatise on fungi as experimental systems for basic and applied research. Volume VI: Human and animal relationships. Y1 - 1996/// CY - Berlin; Germany PB - Springer-Verlag SN - 3540580077 AD - Walsh, T. J.: Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19961200681. Publication Type: Book chapter. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The epidemiology, clinical manifestations, diagnosis and treatment of infections in immunocompromised hosts caused by Candida and Cryptococcus neoformans are discussed. Infections due to other yeasts such as Trichosporon beigelii, Blastoschizomyces capitatus, Malassezia furfur and dematiaceous yeasts such as Wangiella dermatitidis are also briefly considered. KW - candidosis KW - clinical aspects KW - cryptococcosis KW - diagnosis KW - drug therapy KW - epidemiology KW - human diseases KW - immunocompromised hosts KW - immunosuppression KW - infections KW - mycoses KW - opportunistic infections KW - phaeohyphomycosis KW - predisposition KW - therapy KW - yeasts KW - Candida KW - Cryptococcus neoformans KW - Exophiala dermatitidis KW - Malassezia furfur KW - man KW - Trichosporon beigelii KW - Trichosporon capitatum KW - fungi KW - eukaryotes KW - Blastoschizomyces KW - Dipodascaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Malassezia KW - Malasseziales KW - Ustilaginomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Trichosporon KW - Trichosporonaceae KW - Herpotrichiellaceae KW - Chaetothyriales KW - Eurotiomycetes KW - Pezizomycotina KW - Exophiala KW - Blastoschizomyces capitatus KW - candidiasis KW - chemotherapy KW - chromomycosis KW - clinical picture KW - european blastomycosis KW - fungus KW - Hyphomycetes KW - therapeutics KW - Wangiella KW - Wangiella dermatitidis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961200681&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Parental expressed needs: a preliminary guide for services and interventions. AU - Wiener, L. AU - Riekert, K. AU - Steinberg, S. M. AU - Pizzo, P. JO - Journal of HIV/AIDS Prevention and Education for Adolescents and Children JF - Journal of HIV/AIDS Prevention and Education for Adolescents and Children Y1 - 1997/// VL - 1 IS - 1 SP - 35 EP - 52 AD - Wiener, L.: Pediatric HIV Psychosocial Support Program, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972000327. Publication Type: Journal Article. Language: English. Number of References: 10 ref. N2 - This study examined the expressed needs of 150 caregivers of HIV-infected children. The authors assessed the frequency of reported needs and examined the effect of variables that may influence them. The variables include: the caregiver's relationship to the child, his/her HIV-status, and race, the age of the child, the route of transmission, and the child's awareness of his or her own HIV diagnosis. The study delineates the different needs articulated by caregivers for the HIV-infected children at three different developmental stages, and by the caregivers' HIV-status and relationship to the children. The most urgent needs found were for mental health services and health education. The age of the child, the parent's HIV status, and the child's awareness of his or her diagnosis had the most impact on the types of services caregivers requested. KW - acquired immune deficiency syndrome KW - children KW - community care KW - diagnosis KW - effects KW - families KW - health services KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - psychosocial aspects KW - relationships KW - sociology KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - social aspects KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000327&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin. AU - Biro, T. AU - Acs, G. AU - Acs, P. AU - Modarres, S. AU - Blumberg, P. M. JO - Journal of Investigative Dermatology, Symposium Proceedings JF - Journal of Investigative Dermatology, Symposium Proceedings Y1 - 1997/// VL - 2 IS - 1 SP - 56 EP - 60 AD - Biro, T.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19970310475. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 56 ref. Registry Number: 7440-70-2, 404-86-4, 33507-63-0. Subject Subsets: Horticultural Science N2 - C-fiber sensory afferent neurons, which contain neuropeptides such as calcitonin-gene related peptide and substance P, mediate a wide variety of physiologic responses, including chemogenic pain, thermoregulation, and neurogenic inflammation. Capsaicin, the pungent constituent in red pepper [Capsicum spp.], functions to activate and then, at higher doses and longer times, desensitize this class of neurons. This latter response provides the basis for the therapeutic application of capsaicin. A major advance in the field has been the identification of resiniferatoxin, a phorbol-related diterpene from the latex of Euphorbia resinifera, as an analogue of capsaicin that is ultrapotent but with differential selectivity. In particular, resiniferatoxin is only similar in potency for induction of pain but is much more effective for desensitization. Structure-activity analysis in whole animal experiments provides further evidence for dissociation of biologic endpoints, strongly arguing for the existence of vanilloid receptor subclasses. Using resiniferatoxin, it has been possible to define specific, high-affinity receptors for capsaicin both in animal models such as rats, and in man. Of great importance, the pharmacologic characterization in cultured dorsal root ganglion cells of the high-affinity resiniferatoxin-binding site and of the physiologic response believed to be directly coupled to the receptor, viz. calcium uptake, differed in structure-activity and in cooperativity. It is concluded that multiple high-affinity vanilloid receptor subclasses mediate vanilloid response; moreover, the resiniferatoxin-selective subclass of vanilloid receptors is not the voltage-independent, cation-nonselective ion channel as previously believed. Optimization of ligands for the individual vanilloid receptor subclasses should revolutionize this therapeutic area. KW - analogues KW - binding KW - calcium KW - capsaicin KW - inflammation KW - medicinal plants KW - medicinal properties KW - neurons KW - neuropeptides KW - pain KW - pharmacology KW - receptors KW - skin KW - structure activity relationships KW - substance P KW - uptake KW - Capsicum KW - Euphorbia KW - Solanaceae KW - Solanales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Euphorbiaceae KW - Euphorbiales KW - Euphorbia KW - analogs KW - dermis KW - drug plants KW - Euphorbia resinifera KW - medicinal herbs KW - nerve cells KW - neurones KW - officinal plants KW - resiniferatoxin KW - vanilloid receptors KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970310475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. AU - Zimmerman, P. A. AU - Buckler-White, A. AU - Alkhatib, G. AU - Spalding, T. AU - Kubofcik, J. AU - Combadiere, C. AU - Weissman, D. AU - Cohen, O. AU - Rubbert, A. AU - Lam, G. AU - Vaccarezza, M. AU - Kennedy, P. E. AU - Kumaraswami, V. AU - Giorgi, J. V. AU - Detels, R. AU - Hunter, J. AU - Chopek, M. AU - Berger, E. A. AU - Fauci, A. S. AU - Nutman, T. B. AU - Murphy, P. M. JO - Molecular Medicine JF - Molecular Medicine Y1 - 1997/// VL - 3 IS - 1 SP - 23 EP - 36 AD - Zimmerman, P. A.: Correspondence address [Nutman, T. B.]: Laboratory of Parasitic Diseases, Building 5, Rm 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19972004106. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9007-49-2. N2 - CCR5-2 was independently identified and its effects tested on HIV-1 pathogenesis in individuals with contrasting clinical outcomes, defined race, and quantified risk. Mutant CCR5 alleles were sought by directed heteroduplex analysis of genome DNA from random blood donors. Genotypic frequencies were then determined in (1) random blood donors from North America, Asia, and Africa; (2) HIV-1+ individuals; and (3) highly exposed-seronegative homosexuals with quantified risk. CCR5-2 was the only mutant allele found. It was common in Caucasians, less common in other North American racial groups, and not detected in West Africans or Tamil Indians. Homozygous CCR5-2 frequencies differed reciprocally in highly exposed-seronegative (4.5%, n=111) and HIV-1 seropositive (0%, n=614) Caucasians relative to Caucasian random blood donors (0.8%, n=387). This difference was highly significant (P<0.0001). By contrast, heterozygous CCR5-2 frequencies did not differ significantly in the same three groups (21.6, 22.6, and 21.7%, respectively). A 55% increase in the frequency of heterozygous CCR5-2 was observed in both of 2 cohorts of Caucasian homosexual male, long-term nonprogressors compared with other HIV-1+ Caucasian homosexuals (P=0.006) and compared with Caucasian random blood donors. Moreover, Kaplan-Meier estimates indicated that CCR5-2 heterozygous seroconverters had a 52.6% lower risk of developing AIDS than homozygous wild-type seroconverters. The data suggest that homozygous CCR5-2 is an HIV-1 resistance factor in Caucasians with complete penetrance and that heterozygous CCR5-2 slows the rate of disease progression in infected Caucasian homosexuals. Since the majority (~96%) of highly exposed-seronegative individuals tested are not homozygous for CCR5-2, other resistance factors must exist. Since CCR5-2 homozygotes have no obvious clinical problems, CCR5 may be a good target for the development of novel antiretroviral therapy.The nucleic acid sequence of CCR5-2 has been deposited in Genbank, #U66285.Editorial Comment:The impact of CCR5 on HIV infection risk and disease progression.At least 4 chemokine receptors, CXCR4, CCR2B, CCR3 and CCR5 are cofactors, along with CD4 and the viral envelope protein, gp120 in the first step of HIV's entry into cells. Macrophage-tropic strains of HIV use CCR3 and CCR5 whereas T-cell tropic (syncytium producing) strains use CXCR4 and CCR5 preferentially. CCR5 encodes a receptor for the CC chemokines MIP-1a, MIP-1b and RANTES, and is probably, the site through which these chemokines inhibit the growth of macrophage-tropic strains of HIV. CCR5 exists in two alleles: CCR5-1, the wild type and CCR5-2, which has a 32 base-pair deletion. The mutant allele found is racially restricted, found much more frequently in whites than in Afro-Americans, Hispanics or Native-Americans. Homozygosity for the mutant allele is associated with apparently complete resistance to infection with HIV and heterozygosity is associated with a decreased risk of disease progression. This study quantitates these risks. In a cohort of HIV seroconverters followed for more than 10 years, heterozygotes had a 52.6% lower rate of progression to AIDS compared with individuals homozygous for CCR5-1. In addition, in studies of highly exposed but sero-negative individuals, only 4% were heterozygous for CCR5-2, suggesting that other factors for resistance to HIV infection exist, and should be sought. KW - alleles KW - chemokines KW - clinical aspects KW - disease course KW - dna KW - ethnic groups KW - genomes KW - human immunodeficiency viruses KW - pathogenesis KW - resistance KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cc chemokine receptor 5 KW - clinical picture KW - deoxyribonucleic acid KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - non-progressors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein. AU - Rice, W. G. AU - Turpin, J. A. AU - Huang MingJun AU - Clanton, D. AU - Buckheit, R. W., Jr. AU - Covell, D. G. AU - Wallqvist, A. AU - McDonnell, N. B. AU - DeGuzman, R. N. AU - Summers, M. F. AU - Zalkow, L. AU - Bader, J. P. AU - Haugwitz, R. D. AU - Sausville, E. A. JO - Nature Medicine JF - Nature Medicine Y1 - 1997/// VL - 3 IS - 3 SP - 341 EP - 345 AD - Rice, W. G.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, MD 21702, USA. N1 - Accession Number: 19972003001. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7440-66-6. N2 - Nucleocapsid p7 (NCp7) proteins of HIV-1 contain 2 zinc binding domains of the sequence Cys-(X)2-Cys-(X)4-His-(X)4-Cys (CHHC). The spacing pattern and metal-chelating residues (3 Cys, 1 His) of these nucleocapsid CCHC zinc fingers are highly conserved among retroviruses. These CCHC domains are required during both the early and late phases of retroviral replication, making them attractive targets for antiviral agents. Toward that end, a number of antiviral chemotypes were identified that electrophilically attack the sulfur atoms of the zinc-coordinating cysteine residues of the domains. Such nucleocapsid inhibitors were directly virucidal by preventing the initiation of reverse transcription and blocked formation of infectious virus from cells through modification of CCHC domains within Gag precursors. Herein, it is reported that azidocarbonamide (ADA) represents a new compound that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Vendevelde et al. (AIDS Research and Human Retrovirology, 1996, 12, p567) also recently disclosed that ADA inhibits HIV-1 infection via an unidentified mechanism and that ADA was introduced into Phase I/II clinical trials in Europe for advanced AIDS. These studies distinguish ADA as the first known nucleocapsid inhibitor to progress to human trials and provide a lead compound for drug optimization. KW - antiviral agents KW - binding KW - inhibitors KW - nucleocapsid proteins KW - proteins KW - replication KW - transcription KW - treatment KW - zinc KW - Human immunodeficiency virus 1 KW - Retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - azidocarbonamide KW - DNA transcription KW - human immunodeficiency virus type 1 KW - nucleocapsid inhibitors KW - other anti-HIV antivirals KW - Pesticides and Drugs (General) (HH400) KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003001&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin. AU - Husain, S. R. AU - Gill, P. AU - Kreitman, R. J. AU - Pastan, I. AU - Puri, R. K. JO - Molecular Medicine JF - Molecular Medicine Y1 - 1997/// VL - 3 IS - 5 SP - 327 EP - 338 AD - Husain, S. R.: Correspondence address [Puri, R. K.]: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health-Bldg 29B, Rm 2NN10, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006974. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 207137-56-2. N2 - The expression of interleukin-4 receptors (IL-4R) on AIDS-Kaposi's sarcoma (KS) cells and their subunit structure was determined by radioligand receptor binding cross-linking and Northern and RT-PCR analyses. The in vitro effect of IL-4 and recombinant fusion protein made up of circularly permuted IL-4 and a mutated form of Pseudomonas exotoxin IL-4(38-37)-PE38KDEL was examined by clonogenic and protein synthesis inhibition assays. Five AIDS-KS cell lines expressed high-affinity IL-4R with a Kd of 23.5-219 pM. IL-4 appeared to crosslink to one major protein corresponding to 140 kDa and a broad band corresponding to 60-70 kDa. Both cross-linked proteins were immunoprecipitated with an antibody to human IL-4Rβ chain. AIDS-KS cells exhibited IL-4Rβ-specific mRNA. IL-4 caused a modest inhibition (31-34%) of colony formation in two AIDS-KS cell lines tested. IL-4(38-37)-PE38KDEL was found to be highly effective in inhibiting the protein synthesis in all five AIDS-KS examined. The IC50 ranged from 32 to 1225 pM. The cytotoxic action of IL-4 toxin was blocked by an excess of IL-4 exhibiting the specificity of IL-4(38-37)-PE38KDEL. The cytotoxicity of IL-4 toxin observed by a clonogenic assay corroborated well with the IC50 obtained by protein synthesis inhibition assay. Normal human endothelial cells expressed a negligible number of IL-4R (<50 sites/cell) and were less sensitive or not sensitive to IL-4(38-37)-PE38KDEL. KW - antibodies KW - antineoplastic agents KW - binding KW - cell lines KW - cytotoxicity KW - drug therapy KW - effects KW - endothelium KW - exotoxins KW - fusion proteins KW - in vitro KW - inhibition KW - interleukin 4 KW - Kaposi's sarcoma KW - neoplasms KW - protein synthesis KW - proteins KW - receptors KW - sarcoma KW - structure KW - synthesis KW - toxins KW - treatment KW - man KW - Pseudomonas KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pseudomonadaceae KW - Pseudomonadales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - cancers KW - chemotherapy KW - cytotoxic agents KW - endothelial cells KW - protein biosynthesis KW - specificity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. AU - Connors, M. AU - Kovacs, J. A. AU - Krevat, S. AU - Gea-Banacloche, J. C. AU - Sneller, M. C. AU - Flanigan, M. AU - Metcalf, J. A. AU - Walker, R. E. AU - Falloon, J. AU - Baseler, M. AU - Stevens, R. AU - Feuerstein, I. AU - Masur, H. AU - Lane, H. C. JO - Nature Medicine JF - Nature Medicine Y1 - 1997/// VL - 3 IS - 5 SP - 533 EP - 540 AD - Connors, M.: Correspondence address [Lane, H. C.]: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 11B-13, 10 Center Drive, Bethesda, MD 20892-1876, USA. N1 - Accession Number: 19972005099. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells increased only if they were present before initiation of therapy. Disruptions of the CD4+ TCR repertoire were most prevalent in patients with the lowest CD4+ T-cell counts. Antiviral or IL-12 therapy-induced increases in CD4+ T-cell counts led to only minor changes in previously disrupted repertoires. Thus, CD4+ T-cell death mediated by HIV-1 infection may result in a preferential decline in the number of naive CD4+ T cells and disruptions of the CD4+ T-cell repertoire that are not immediately corrected by antiviral or immune-based therapies.Editorial Comment:This is an extremely interesting and timely study which demonstrates that the CD4+ T-lymphocytic repertoire is not fully restored by potent antiretrovirals, with or without an immune-based therapy, in this case interleukin-12 (IL-12). Although there has been a renaissance in the treatment of HIV-1 disease, with potent combination chemotherapy, this has not always been fully helpful in immune reconstituting individuals with dramatically depleted CD4+ T-lymphocytes, prior to therapy. As such, it is also questionable whether the CD4+ T-cell diverse repertoire is at all corrected with these approaches. This is an interesting clinical and basic science study which demonstrates that there remains T-cell repertoire disruptions in patients with initial significant depletions in CD4+ lymphocytes, prior to antiviral therapy. As well, at least this one type of immune-based therapy was not fully helpful. Further studies and approaches are critically needed at this point in the AIDS epidemic in attempts to immune reconstitute patients, once viral replication has been functionally ablated by combination antiviral therapeutics. This paper confirms previous reports that, as the CD4+ count falls in progressive HIV infection, the naive CD4+ population is more severely affected than is the memory population (perhaps due to more resilient replicative potential of memory cells). Concordantly, memory cells recovered more rapidly after antiviral and IL2 therapy; and disturbingly, if the naive population was undetectable before therapy it did not reappear as the total CD4+ count rose. For TCR repertoire analysis a sophisticated technique was utilized. PCR amplification of the variable VDJ regions of TCR-β gene yields PCR fragments of on average 8 different lengths due to differences in amount of nucleotide additions. PCR was performed for each of the 22 TCR-β gene families and amount of PCR fragment of each length quantitated, allowing the repertoire analysis to be divided into 176 discrete measurements. Monozygotic twins discordant for HIV infection were studied, demonstrating obvious distortions of the TCR repertoire in HIV infection and indicating a much more severe limitation of repertoire than indicated by total CD4+ counts. Even as CD4+ counts rose towards normal levels after therapy, a normal TCR repertoire was not usually restored. KW - acquired immune deficiency syndrome KW - amplification KW - antigens KW - antiviral agents KW - CD4 antigens KW - CD4+ lymphocytes KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - infection KW - leukocyte count KW - patients KW - phenotypes KW - polymerase chain reaction KW - replication KW - T lymphocytes KW - treatment KW - viral replication KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - AIDS KW - antigenicity KW - CD4 KW - CD4+ cells KW - cell count KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunogens KW - PCR KW - T cells KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005099&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite. AU - Rogers, M. J. AU - Bukhman, Y. V. AU - McCutchan, T. F. AU - Draper, D. E. JO - RNA JF - RNA Y1 - 1997/// VL - 3 IS - 8 SP - 815 EP - 820 AD - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980802641. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology N2 - Temperature-dependent hyperchromicity profiles of synthetic RNAs corresponding to domains in the plastid and cytoplasmic RNAs of Plasmodium falciparum were examined. Thiostrepton induced a tertiary structure in the plastid-like fragment similar to that seen in eubacterial rRNA, even though they share only about 60% sequence identity. A single point mutation in the plastid-like fragment removed thiostrepton-dependent tertiary structure formation. Thus, the plastid and eubacterial RNAs share a stabilized tertiary structure induced by the drug. This direct indicator of drug sensitivity in eubacteria suggests that the plastid-encoded ribosome is similarly sensitive to thiostrepton and that the plastid is the site of drug action. Correlation of thiostrepton-sensitive and -resistant phenotypes with physical parameters suggests thiostrepton resistance as a selectable marker for plastid transformation. KW - antibiotics KW - antiprotozoal agents KW - mode of action KW - molecular genetics KW - mutations KW - parasites KW - ribosomes KW - RNA KW - transcription KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA transcription KW - ribonucleic acid KW - thiostrepton KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802641&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - CCR2 chemokine receptor and AIDS progression. AU - Smith, M. W. AU - Carrington, M. AU - Winner, C. AU - Lomb, D. AU - Dean, M. AU - Huttley, G. AU - O'Brien, S. J. T2 - Nature Medicine JO - Nature Medicine JF - Nature Medicine Y1 - 1997/// VL - 3 IS - 10 SP - 1052 EP - 1053 AD - Smith, M. W.: Science Applications International Corp., Frederick Cancer and Development Center, National Cancer Institute, Frederick MD 21702-1201, USA. N1 - Accession Number: 19972010665. Publication Type: Correspondence. Language: English. Number of References: 8 ref. N2 - These correspondents previously reported an association between the CCR2-641 chemokine receptor mutation and delayed onset of AIDS. Michael, et al. (Nature Medicine (1997) 3 1160) have now examined the San Francisco Mens' Health Study AIDS (SFMHS) cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the CCR2-641 association. It is suggested by Smith et al. that the most likely explanation for the inability of SFMHS to detect the CCR2-641 effect is the disposition of the cohort, which includes primarily seroprevalent patients and other aspects which could mask the effect. KW - acquired immune deficiency syndrome KW - chemokines KW - cytokines KW - disease course KW - effects KW - genetic polymorphism KW - genotypes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - patients KW - receptors KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - disease progression KW - HUMAN IMMUNODEFICIENCY VIRUS KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010665&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. AU - Soldan, S. S. AU - Berti, R. AU - Salem, N. AU - Secchiero, P. AU - Flamand, L. AU - Calabresi, P. A. AU - Brennan, M. B. AU - Maloni, H. W. AU - McFarland, H. F. AU - Lin HunChi AU - Patnaik, M. AU - Jacobson, S. JO - Nature Medicine JF - Nature Medicine Y1 - 1997/// VL - 3 IS - 12 SP - 1394 EP - 1397 AD - Soldan, S. S.: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 5B-16, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19982009176. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9007-49-2. N2 - Recently, HHV-6 has been reported to be present in active multiple sclerosis (MS) plaques. In order to extend these observations, sera from 36 MS patients (22 with relapsing-remitting MS (RRMS) and 14 with chronic progressive MS (CPMS)), 31 patients with other neurological diseases, 21 with other autoimmune diseases, and 14 asymptomatic healthy controls, were obtained from a medical centre in Maryland, USA, and were assayed for IgM antibodies to HHV-6 early antigen (p41/38) by enzyme immunoassay [date not given]. There was a highly significant difference in the anti-HHV-6 IgM response to HHV-6 p41/38, particularly between the RRMS group and normal controls (P<0.0011). In addition, studies to detect active HHV-6 DNA in patient sera using a nested PCR technique revealed that no HHV-6 DNA could be amplified from the serum of 47 non-MS patients, but that positive HHV-6 DNA signals could be demonstrated in 15 of 50 (30%) MS patients (14 RRMS, 1 CPMS) (P<0.0001). It is concluded that these studies support the hypothesis that HHV-6 plays a role in the aetiology of MS. KW - aetiology KW - antibodies KW - detection KW - DNA KW - human diseases KW - IgM KW - multiple sclerosis KW - nervous system diseases KW - serology KW - seroprevalence KW - viral antigens KW - viral diseases KW - Maryland KW - USA KW - human herpesvirus 6 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Roseolovirus KW - Betaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - causal agents KW - deoxyribonucleic acid KW - etiology KW - neuropathy KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009176&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of HMBP-2, a DNA-binding protein that binds to HIV-1 LTR when only one of the three Sp1 sites is methylated. AU - Shao, W. JO - Journal of Biomedical Science JF - Journal of Biomedical Science Y1 - 1997/// VL - 4 IS - 1 SP - 39 EP - 46 AD - Shao, W.: SAIC, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19972005120. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 77-78-1. N2 - HIV-1 methylation binding protein-1 (HMBP-1) (formerly called HMBP) is a protein found in human cell nuclei that binds with enhanced affinity to the fragment of the HIV-1 long terminal repeat sequence (LTR) containing 3 Sp1 sites when all 3 sites are methylated. HMBP-2 is another protein present in the nuclei of human T helper lymphocytes and HeLa cells that binds to the HIV-1 LTR. HMBP-2 binds preferentially to the same region of the HIV-1 LTR as does HMBP-1, but HMBP-2 binds best when only one of the 3 Sp1 sites is methylated. HMBP-2 can be separated from HMBP-1 chromatographically, and dimethyl sulfate (DMS) methylation interference analysis indicates that their binding sites are not identical. HMBP-2 represents a novel protein factor capable of binding to a partially methylated region of the HIV-1 LTR. KW - dimethyl sulfate KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - interference KW - lymphocytes KW - microbiology KW - nuclei KW - proteins KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - cell nuclei KW - dimethyl sulphate KW - genomic structure KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - LTR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005120&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients. AU - Lucey, D. R. AU - Pinto, L. A. AU - Bethke, F. R. AU - Rusnak, J. AU - Melcher, G. P. AU - Hashemi, F. N. AU - Landay, A. L. AU - Kessler, H. A. AU - Paxton, R. J. AU - Grabstein, K. AU - Shearer, G. M. JO - Clinical and Diagnostic Laboratory Immunology JF - Clinical and Diagnostic Laboratory Immunology Y1 - 1997/// VL - 4 IS - 1 SP - 43 EP - 48 SN - 1071-412X AD - Lucey, D. R.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972002827. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2. N2 - The effects of IL-15 on induction of lymphokine-activated killer (LAK) cells, gamma interferon (IFN-γ) production from HIV-positive peripheral blood mononuclear cells (PBMCs), and HIV production from PBMCs were studied. Induction of LAK cells by IL-15 was found in eight of eight HIV-positive donors. Incubation of PBMCs from some donors with IL-15 (1, 10, 50, and 100 ng/ml) induced production of IFN-γ. The effect of IL-15 was compared with that of IL-2 on HIV replication in PBMCs from five HIV-positive patients and four HIV-negative donors whose PBMCs were infected in vitro with HIV. Levels of HIV p24 antigen were moderately lower in the presence of 10 ng of IL-15 per ml than with 10 ng of IL-2 per ml, but they were similar for 100 and 500 ng of each cytokine per ml. It is concluded that IL-15 can induce LAK cell activity in HIV-seropositive patients and can stimulate IFN-γ production from PBMCs of some donors. IL-15 stimulates levels of HIV production from PBMCs which are similar to or moderately lower than those obtained with IL-2, depending on cytokine concentration. KW - antigens KW - B lymphocytes KW - blood KW - cells KW - clinical aspects KW - core protein p24 KW - cytokines KW - donors KW - effects KW - hiv-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - in vitro KW - interferon KW - interleukin 15 KW - interleukin 2 KW - interleukins KW - patients KW - replication KW - T lymphocytes KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - B cells KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunogens KW - immunological reactions KW - p24 KW - p24 antigen KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002827&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - A minor groove binding track in reverse transcriptase. AU - Bebenek, K. AU - Beard, W. A. AU - Darden, T. A. AU - Li LePing AU - Prasad, R. AU - Luxon, B. A. AU - Gorenstein, D. G. AU - Wilson, S. H. AU - Kunkel, T. A. T2 - Nature Structural Biology JO - Nature Structural Biology JF - Nature Structural Biology Y1 - 1997/// VL - 4 IS - 3 SP - 194 EP - 197 SN - 1072-8368 AD - Bebenek, K.: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19972003798. Publication Type: Correspondence. Language: English. Number of References: 27 ref. Registry Number: 9068-38-6. N2 - Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track. KW - binding KW - HIV-1 infections KW - human diseases KW - interactions KW - microbiology KW - reverse transcriptase KW - structural genes KW - structure KW - synthesis KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - RT gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003798&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. AU - Cai, M. L. AU - Zheng, R. AU - Caffrey, M. AU - Craigie, R. AU - Clore, G. M. AU - Gronenborn, A. M. JO - Nature Structural Biology JF - Nature Structural Biology Y1 - 1997/// VL - 4 IS - 7 SP - 567 EP - 577 SN - 1072-8368 AD - Cai, M. L.: Laboratories of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. N1 - Accession Number: 19972009669. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Registry Number: 9007-49-2, 7440-66-6. N2 - The solution structure of the N-terminal zinc binding domain (residues 1-55; IN1-55) of HIV-1 integrase has been solved by NMR spectroscopy. IN1-55 is dimeric, and each monomer comprises four helices with the zinc tetrahedrally coordinated to His 12, His 16, Cys 40, and Cys 43. IN1-55 exists in two interconverting conformational states that differ with regard to the coordination of the two histidine side chains to zinc. The different histidine arrangements are associated with large conformational differences in the polypeptide backbone (residues 9-18) around the coordinating histidines. The dimer interface is predominantly hydrophobic and is formed by the packing of the N-terminal end of helix 1, and helices 3 and 4. The monomer fold is remarkably similar to that of a number of helical DNA binding proteins containing a helix-turn-helix (HTH) motif with helices 2 and 3 of IN1-55 corresponding to the HTH motif. In contrast to the DNA binding proteins where the second helix of the HTH motif is employed for DNA recognition, IN1-55 uses this helix for dimerization. KW - binding KW - DNA KW - DNA binding proteins KW - enzymes KW - human diseases KW - microbiology KW - polypeptides KW - proteins KW - structural genes KW - structure KW - zinc KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - dimers KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009669&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of squamous cell conjunctival cancer. AU - Sun, E. C. AU - Fears, T. R. AU - Goedert, J. J. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1997/// VL - 6 IS - 2 SP - 73 EP - 77 SN - 1055-9965 AD - Sun, E. C.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. N1 - Accession Number: 19972009046. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health N2 - To examine the relationship between UVB radiation exposure and squamous cell carcinoma of the conjunctiva (SCCC), US population-based age-adjusted incidence rates of SCCC and of conjunctival melanoma and squamous cell cancer of the eyelid reported during 1973-1990, were plotted against the UVB insolation of each registry site. Incidence data were examined further for patterns of second primary cancers among people with SCCC. SCCC was rare in the USA, with an incidence rate of 0.03 per 100 000 persons, although the rate was approximately 5-fold higher among males and whites. Regression analysis suggested a link between UVB exposure and SCCC rates (β=2.25; r=0.58) that was as strong as that for squamous cell carcinoma of the eyelid (β=2.73; r=0.62) and much stronger than for conjunctival melanoma (β=0.28; r=0.02). Risk of a second malignancy after SCCC was not increased overall (20 observed and 14.1 expected), although a significant excess of salivary gland cancer (4 observed and 0.03 expected) and a borderline excess of lung cancer (6 observed and 2.4 expected) were noted. These observations suggest that UV radiation contributes to SCCC development. Additional research is needed to define the other exposures and host susceptibility that may interact with UV-related genetic damage in the multifactorial development of this rare neoplasm. KW - aetiology KW - carcinoma KW - conjunctiva KW - epidemiology KW - exposure KW - eyelids KW - eyes KW - human diseases KW - melanoma KW - neoplasms KW - radiation KW - risk factors KW - solar radiation KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - causal agents KW - conjunctival cancer KW - etiology KW - sunlight KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009046&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Kuru: forty years later, a historical note. AU - Liberski, P. P. AU - Gajdusek, D. C. JO - Brain Pathology JF - Brain Pathology Y1 - 1997/// VL - 7 IS - 1 SP - 555 EP - 560 AD - Liberski, P. P.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA. N1 - Accession Number: 19972008875. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Tropical Diseases KW - clinical aspects KW - epidemiology KW - human diseases KW - kuru KW - prion diseases KW - reviews KW - Oceania KW - Papua new guinea KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - APEC countries KW - Commonwealth of Nations KW - Developing Countries KW - New Guinea KW - Melanesia KW - Australasia KW - Oceania KW - Pacific Islands KW - clinical picture KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cellular proteins in HIV virions. AU - Ott, D. E. JO - Reviews in Medical Virology JF - Reviews in Medical Virology Y1 - 1997/// VL - 7 IS - 3 SP - 167 EP - 180 SN - 1052-9276 AD - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972009414. Publication Type: Journal Article. Language: English. Number of References: 67 ref. N2 - HIV-1 virions contain both virus-encoded and cellular proteins. Recent advances in the detection, isolation, and functional characterization of host proteins incorporated in the virion have begun to furnish new insights into the interactions between virus and cell. The acquisition of host proteins by HIV-1 may also influence viral pathology in vivo. This article reviews the detection and analysis of host proteins found in HIV-1 particles and presents some potential roles that these proteins might play in the biology of the virus. KW - cells KW - characterization KW - detection KW - HIV-1 infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - major histocompatibility complex KW - microbiology KW - pathogenesis KW - pathology KW - proteins KW - reviews KW - surface proteins KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - histocompatibility complex KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - membrane proteins KW - virions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - AIDS: decline and fall of immune surveillance? AU - Feinberg, M. B. AU - McLean, A. R. JO - Current Biology JF - Current Biology Y1 - 1997/// VL - 7 IS - 3 SP - R136 EP - R140 SN - 0960-9822 AD - Feinberg, M. B.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003399. Publication Type: Journal Article. Language: English. Number of References: 10 ref. N2 - The interaction of HIV-1 with its host is discussed, in light of recent observations which cast doubt on the view that cytotoxic T cells play a key role in keeping HIV-1 infection in check, and that it is this mechanism of immune surveillance that permits progression to AIDS. This article discusses the questions of how HIV-1 maintains a chronic persistent infection, and why the immune system, while apparently active in its response to the virus, is ultimately unable to control HIV-1 infection effectively and protect the infected individual from progression to AIDS. KW - acquired immune deficiency syndrome KW - cell mediated immunity KW - cytotoxic t lymphocytes KW - disease course KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cellular immunity KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003399&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin intake: a possible determinant of plasma homocyst(e)ine among middle-aged adults. AU - Shimakawa, T. AU - Nieto, F. J. AU - Malinow, M. R. AU - Chambless, L. E. AU - Schreiner, P. J. AU - Szklo, M. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1997/// VL - 7 IS - 4 SP - 285 EP - 293 SN - 1047-2797 AD - Shimakawa, T.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethedsa, MD, USA. N1 - Accession Number: 19971409106. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 7440-70-2, 68-19-9, 59-30-3, 6027-13-0, 7439-89-6, 7723-14-0, 65-23-6, 83-88-5, 59-43-8. Subject Subsets: Human Nutrition N2 - To examine the relationship between vitamin intakes and plasma homocysteine, dietary intake data was examined from a case-control study of 322 middle-aged individuals with atherosclerosis in the carotid artery and 318 control subjects without evidence of this disease. All these individuals were selected from a probability sample of 15 800 men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study, USA. Plasma homocysteine was inversely associated with intakes of folate, vitamin B6 and vitamin B12 (controls only for this vitamin). Among non-users of vitamin supplement products, on average each tertile increase in intake of these vitamins was associated with 0.4 to 0.7 µmol/litre decrease in plasma homocysteine. There were inverse associations between plasma homocysteine and thiamin, riboflavin, calcium, phosphorus and iron. There were no significant associations between methionine and protein intake and plasma homocysteine. In almost all analyses, cases and controls showed similar associations between dietary variables and plasma homocysteine. Plasma homocysteine among users of vitamin supplement products was 1.5 µmol/litre lower than that among non-users. KW - adults KW - atherosclerosis KW - blood KW - calcium KW - consumption KW - cyanocobalamin KW - diet KW - folic acid KW - homocysteine KW - iron KW - men KW - minerals KW - nutrition surveys KW - phosphorus KW - pyridoxine KW - riboflavin KW - risk factors KW - supplements KW - thiamin KW - trace elements KW - vitamin b12 KW - vitamins KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aneurin KW - arteriosclerosis KW - cobalamin KW - folacin KW - folate KW - microelements KW - nutritional surveys KW - thiamine KW - United States of America KW - vitamin B1 KW - vitamin B2 KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterocyclic amines, cytochrome P4501A2, and N-acetyltransferase: issues involved in incorporating putative genetic susceptibility markers into epidemiological studies. AU - Sinha, R. AU - Caporaso, N. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1997/// VL - 7 IS - 5 SP - 350 EP - 356 SN - 1047-2797 AD - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA. N1 - Accession Number: 19971411227. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9035-51-2. Subject Subsets: Human Nutrition N2 - Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this variation may be genetic, as in the case of NAT2, or genetic and environmental as with CYP1A2. The effects of HCAs on the NAT2 and CYP1A2 phenotypes were examined in 33 men and 33 women. The subjects consumed a low HCA-containing diet for 1 week followed by a high HCA diet for the subsequent week. The subjects were phenotyped for CYP1A2 and NAT2 at the time of entry into the study (free-living), 1 week later (end of low-HCA or low-induction diet) and 2 weeks later (end of high-HCA or high-induction diet). Consistent with genetic sources of variability, NAT2 showed little effect of a high-HCA diet and exhibited high intraindividual correlation. CYP1A2, in contrast, was induced by a high-HCA diet and exhibited a more modest intraindividual correlation. It is concluded that incorporating putative genetic susceptibility makers in population studies requires consideration of issues of induction and inhibition of metabolizing enzymes, and effects of covariates. KW - amines KW - carcinogens KW - cooking KW - cytochrome P-450 KW - enzyme activity KW - genetics KW - heterocyclic nitrogen compounds KW - markers KW - meat KW - mutagens KW - susceptibility KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - activation KW - N-acetyltransferase KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411227&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. AU - Lee, C. G. L. AU - Jeang KuanTeh AU - Martin, M. A. AU - Pastan, I. AU - Gottesman, M. M. JO - Antisense and Nucleic Acid Drug Development JF - Antisense and Nucleic Acid Drug Development Y1 - 1997/// VL - 7 IS - 5 SP - 511 EP - 522 AD - Lee, C. G. L.: Laboratory of Cell Biology, Bldg 37, Rm 1B22, National Cancer Institute, NIH, 37 Convent Drive, MSC 4255, Bethesda, MD 20895-4255, USA. N1 - Accession Number: 19982000166. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 63231-63-0. N2 - Harvey sarcoma-based retroviral vectors encoding the multidrug resistance gene (MDR1) multidrug transporter with a hammerhead ribozyme targeted to highly conserved sequences within the HIV-1 U5 LTR segment have been constructed in a bicistronic format. The internal ribosome entry site (IRES) from encephalomyocarditis virus was used to initiate translation of the MDR1 mRNA. The ribozyme remained functional despite being tethered to MDR1. Long-term, high-level expression of both the ribozyme and MDR1, as evident by RT-PCR and FACS analysis, was observed in a human T cell line containing the construct selected with vincristine, a cytotoxic substrate for the multidrug transporter. KW - antiviral agents KW - cell lines KW - cytotoxicity KW - drug resistance KW - enzymes KW - genes KW - genomes KW - HIV-1 infections KW - human diseases KW - multiple drug resistance KW - RNA KW - T lymphocytes KW - translation KW - treatment KW - vectors KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - conserved sequences KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - ribozymes KW - RNA translation KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000166&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors and early detection of lung cancer in a cohort of Chinese tin miners. AU - Qiao YouLin AU - Taylor, P. R. AU - Yao ShuXiang AU - Erozan, Y. S. AU - Luo XueChang AU - Barrett, M. J. AU - Yan QingYuan AU - Giffen, C. A. AU - Huang ShaoQiang AU - Maher, M. M. AU - Forman, M. R. AU - Tockman, M. S. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1997/// VL - 7 IS - 8 SP - 533 EP - 541 SN - 1047-2797 AD - Qiao YouLin: Cancer Prevention Studies Branch, National Cancer Institute, National Institute of Health, Executive Plaza North, Suite 211, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19982003900. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-38-2, 10043-92-2, 7440-31-5. Subject Subsets: Tropical Diseases N2 - In order to examine risk factors and establish a biological specimen and data bank for the study of early markers of lung cancer a dynamic cohort study was designed using an ongoing lung cancer screening programme among radon- and arsenic-exposed tin miners in Yunnan, China. Through the first 4 years of the study (1992-95), 8346 miners aged ≥40 years with >10 years of occupational exposure were enrolled, risk factors were assessed, annual sputum and chest radiographs were obtained and biological specimens were collected. 243 new lung cancer cases were identified by the end of 1995. Radon and arsenic exposures were the predominant risk factors (4-fold increased risk in the highest quartile of radon exposure and a nearly 5-fold relative risk for highest quartile of arsenic exposure), but lung cancer risk was also associated with chronic bronchitis and silicosis (age adjusted relative risks, 1.73 and 1.46 respectively), as well as a number of measures of exposure to tobacco smoke, including early age of first use, duration, and cumulative exposure (relative risk, 1.59 for current tobacco smoking). KW - arsenic KW - bronchitis KW - human diseases KW - lung cancer KW - lungs KW - miners KW - neoplasms KW - occupational hazards KW - radon KW - risk factors KW - silicosis KW - tin KW - tobacco smoking KW - China KW - Yunnan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - South Western China KW - China KW - cancers KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003900&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cause-specific mortality in women receiving hormone replacement therapy. AU - Schairer, C. AU - Adami, H. O. AU - Hoover, R. AU - Persson, I. JO - Epidemiology JF - Epidemiology Y1 - 1997/// VL - 8 IS - 1 SP - 59 EP - 65 SN - 1044-3983 AD - Schairer, C.: Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USA. N1 - Accession Number: 19972008090. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 50-28-2. Subject Subsets: Public Health N2 - To assess the risks and benefits of menopausal hormone replacement therapy, a 23 246-member, population-based cohort of Swedish women who were prescribed menopausal oestrogens for a mean of 8.6 years, was followed for mortality. Compared with the general population, the standardized mortality ratio for all-cause mortality in this cohort was 0.77 (95% confidence limits = 0.73, 0.81). Deaths in each of the 12 major categories of causes of death except for injuries occurred 12-86% less frequently than expected. Four specific causes of death were examined in detail according to the type of hormone prescribed, namely weak oestrogens (primarily oestriol), more potent oestrogens (primarily oestradiol and conjugated oestrogens) in combination with a progestin, and more potent oestrogens without a progestin. Mortality from endometrial cancer was not related to the prescription of weak oestrogens or an oestrogen-progestin combination, but mortality was 40% higher in women prescribed more potent oestrogens without a progestin. Women prescribed weak oestrogens, more potent oestrogens and the combined oestrogen-progestin regimen were at reduced risk of death from ischaemic heart disease (standardized mortality ratios of 0.7, 0.6 and 0.4, respectively). The more potent oestrogens and the oestrogen-progestin combination were associated with a marked reduction in risk of intracerebral haemorrhage (standardized mortality ratios of 0.4 and 0.6, respectively) and "other" cerebrovascular disease, but not other types of stroke. The concern that use of progestins would lead to psychic disorders related to suicide was unsupported by these results. Breast cancer results were reported separately. These results provided little evidence of an adverse effect of the combined oestrogen-progestin regimen in comparison with oestrogens alone on mortality. It is concluded that both selection factors and biology may contribute to the almost across-the board-reduction in mortality associated with hormone replacement therapy. KW - breast cancer KW - cardiovascular diseases KW - causes of death KW - cerebrovascular disorders KW - death KW - endometrial cancer KW - estradiol KW - haemorrhage KW - heart KW - heart diseases KW - hormone replacement therapy KW - mortality KW - myocardial ischaemia KW - neoplasms KW - prescriptions KW - risk factors KW - trauma KW - women KW - Europe KW - Sweden KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - bleeding KW - cancers KW - coronary diseases KW - death rate KW - hemorrhage KW - ischaemic heart disease KW - myocardial ischemia KW - oestradiol KW - traumas KW - Non-communicable Human Diseases and Injuries (VV600) KW - Women (UU500) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008090&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reproductive factors, oral contraceptive use, and risk of colorectal cancer. AU - Troisi, R. AU - Schairer, C. AU - Chow WongHo AU - Schatzkin, A. AU - Brinton, L. A. AU - Fraumeni, J. F., Jr. JO - Epidemiology JF - Epidemiology Y1 - 1997/// VL - 8 IS - 1 SP - 75 EP - 79 SN - 1044-3983 AD - Troisi, R.: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7374, USA. N1 - Accession Number: 19972008091. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health N2 - Among 57 529 women (aged 31-90 years) from the USA, who volunteered for a nationwide breast cancer screening programme during 1973-80, 154 pathologically confirmed cases of colon cancer and 49 cases of rectal cancer were observed in up to 10 years of follow-up (388 555 person-years). Parity was not associated with risk of colorectal cancer (age-adjusted rate ratio for ≥4 children vs. no children = 1.0; 95% confidence interval (CI) 0.72-1.5), although decreases in proximal colon cancer and increases in distal colon cancer were observed among parous women. The effect of parity did not vary by age at diagnosis. There was no strong or consistent association for age at menarche, age at first birth, or age at natural menopause. In addition, oral contraceptive use, reflecting mainly past use, was unrelated to risk of colorectal cancer (rate ratio = 1.0; 95% CI 0.75-1.4). These results did not support the hypothesis that reproductive events or oral contraceptives influence the development of colorectal cancer. KW - colon KW - colorectal cancer KW - contraceptives KW - human diseases KW - mortality KW - neoplasms KW - oral contraceptives KW - parity KW - rectum KW - risk factors KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - death rate KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional issues and HIV/AIDS: assessment and treatment strategies. AU - Walse, C. AU - Zafonte, M. AU - Muir Bowers, J. JO - Journal of the Association of Nurses in AIDS Care JF - Journal of the Association of Nurses in AIDS Care Y1 - 1997/// VL - 8 IS - 6 SP - 71 EP - 80 AD - Walse, C.: National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982000223. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - This article summarizes aetiologies of HIV-associated nutritional deficiencies, reviews important components of nutrition assessment (including nutrition-related side effects of approved medications commonly used in HIV disease), provides an overview of common nutritional problems and interventions, and lists some available nutritional resources. KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME KW - adverse effects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - nutrition KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000223&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse chromosome 5. AU - McAllister, K. A. AU - Ramachandran, S. AU - Haugen-Strano, A. AU - Fiedorek, F. T., Jr. AU - Wiseman, R. W. JO - Mammalian Genome JF - Mammalian Genome Y1 - 1997/// VL - 8 IS - 7 SP - 540 EP - 541 SN - 0938-8990 AD - McAllister, K. A.: Laboratory of Molecular Carcingenesis, National Institute of Environmental Health Sciences, Triangle Park, North Carolina 27709, USA. N1 - Accession Number: 19970107293. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding N2 - The mouse breast cancer 2 gene (Brca2) was mapped to Chr 5: centromere-D5Mit30-(1.26 ± 0.89)-D5Mit63-(1.90 ± 1.09)-D5Mit51/D5Mit101-IM-(1.26 ± 0.89)-Ipf1-(0.63 ± 0.63)-Brca2/D5Mit122/D5Mit144/D5Mit192/D5Mit286-telomere. A (TTTGG)8 simple sequence repeat was found in intron 10 of the mouse Brca2 gene (EMBL/GenBank accession number U89503). KW - biotechnology KW - breast cancer KW - chromosomes KW - gene mapping KW - neoplasms KW - nucleotide sequences KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - breast cancer susceptibility gene KW - cancers KW - DNA sequences KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970107293&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of vitamin in differentiation and skin carcinogenesis. AU - Luca, L. M. de AU - Kosa, K. AU - Andreola, F. JO - Journal of Nutritional Biochemistry JF - Journal of Nutritional Biochemistry Y1 - 1997/// VL - 8 IS - 8 SP - 426 EP - 437 SN - 0955-2863 AD - Luca, L. M. de: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19971411306. Publication Type: Journal Article. Language: English. Number of References: 99 ref. Registry Number: 302-79-4, 68-26-8. Subject Subsets: Human Nutrition N2 - Vitamin A is reviewed under the headings: Retinoid metabolism; Retinoids and epithelial differentiation; Epithelial, cell type specific expression of retinoid receptor transcripts; Retinoid-steroid interactions in cervical epithelial differentiation; The two families of retinoid receptors; Speculations on orders of receptor interactions; Mutants of retinoic acid receptors and their biological consequences; and Chemoprevention of skin carcinogenesis by dietary retinoic acid. KW - carcinogenesis KW - cell differentiation KW - differentiation KW - epithelium KW - retinoic acid KW - retinoids KW - retinol KW - reviews KW - skin KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - cytodifferentiation KW - dermis KW - tretinoin KW - vitamin A KW - vitamin A acid KW - vitamin A alcohol KW - vitamin A compounds KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The two faces of essential fatty acids. AU - Lands, W. E. M. JO - INFORM - International News on Fats, Oils and Related Materials JF - INFORM - International News on Fats, Oils and Related Materials Y1 - 1997/// VL - 8 IS - 11 SP - 1141 EP - 1147 SN - 0897-8026 AD - Lands, W. E. M.: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19981406144. Publication Type: Journal Article. Language: English. Number of References: 88 ref. Subject Subsets: Human Nutrition N2 - This review, based on a talk at the 1997 American Oil Chemists' Society (AOCS) Annual meeting and Expo in Seattle, USA in May [1997], describes laboratory approaches to essential fatty acid research from a historical perspective, including investigations into the essential actions of fatty acids in membrane structures and in hormone formation (the "two faces" of essential fatty acids) and the role of n-3 and n-6 acids. KW - essential fatty acids KW - nutrition research KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406144&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of natural killer cells in innate resistance to protozoan infections. AU - Scharton-Kersten, T. M. AU - Sher, A. JO - Current Opinion in Immunology JF - Current Opinion in Immunology Y1 - 1997/// VL - 9 IS - 1 SP - 44 EP - 51 SN - 0952-7915 AD - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970804526. Publication Type: Journal Article. Language: English. Number of References: 86 ref. Subject Subsets: Protozoology N2 - The role of natural killer (NK) cells as major effectors of innate resistance to protozoan parasites is reviewed in relation to work both in mice and in man. The principal mechanism by which NK cells control the growth of these pathogens is considered. Recent studies which have identified a series of positive and negative signals provided by cytokines and cellular interactions which regulate protozoa-induced NK cell function are discussed. KW - cytokines KW - natural killer cells KW - parasites KW - resistance KW - reviews KW - man KW - mice KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - invertebrates KW - general account KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804526&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection. AU - Weissman, D. AU - Fauci, A. S. JO - Clinical Microbiology Reviews JF - Clinical Microbiology Reviews Y1 - 1997/// VL - 10 IS - 2 SP - 358 EP - 367 SN - 0893-8512 AD - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19972006539. Publication Type: Journal Article. Language: English. Number of References: 159 ref. N2 - This review focuses on the role of dendritic cells in the initiation and propagation of viral replication, particularly in the context of future directions of research and therapeutic strategies. KW - cells KW - dendritic cells KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immune system KW - immunology KW - immunopathology KW - pathogenesis KW - replication KW - reviews KW - vaccines KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006539&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Response to purified chick embryo cell rabies vaccine administered intradermally for post-exposure prophylaxis. AU - Madhusudana, S. N. AU - Anand, P. N. JO - National Medical Journal of India JF - National Medical Journal of India Y1 - 1997/// VL - 10 IS - 3 SP - 115 EP - 116 SN - 0970-258X AD - Madhusudana, S. N.: National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. N1 - Accession Number: 19972009392. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Tropical Diseases N2 - An intradermal regimen with purified chick embryo vaccine for post-exposure immunization of rabies was evaluated in 25 subjects from India who had nursed or casually handled a rabies patient. There was 100% seroconversion and all the subjects developed neutralizing antibody levels higher than the adequate level of 0.5 IU/ml. Only minor side-effects were observed in some subjects. The feasibility of using this regimen in routine practice is considered. KW - antibodies KW - disease prevention KW - human diseases KW - immunization KW - rabies KW - regimens KW - seroconversion KW - vaccines KW - Asia KW - India KW - Karnataka KW - man KW - rabies virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lyssavirus KW - Rhabdoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - immune sensitization KW - Mysore KW - post-exposure immunization KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009392&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Healthcare institutions as 'hot zones': emerging and re-emerging pathogens. AU - Henderson, D. K. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1997/// VL - 10 IS - 4 SP - 310 EP - 318 SN - 0951-7375 AD - Henderson, D. K.: Clinical Care, Warren A Magason Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003804. Publication Type: Journal Article. Language: English. Number of References: 129 ref. Subject Subsets: Public Health N2 - Recent information about occupational and nosocomial pathogens is reviewed, analysing the potential for health care institutions to become "hot zones". Nosocomial risks to patients from Staphylococcus aureus, coagulase-negative staphylococci and vancomycin-resistant enterococci, and risks to patients and occupational risks to health care workers from drug resistant tuberculosis and blood borne pathogens are discussed. Prevention strategies are briefly considered. KW - bacterial diseases KW - drug resistance KW - health care workers KW - hospitals KW - human diseases KW - immunocompromised hosts KW - infections KW - nosocomial infections KW - occupational hazards KW - occupational health KW - opportunistic infections KW - risk factors KW - tuberculosis KW - Enterococcus KW - man KW - Mycobacterium tuberculosis KW - Staphylococcus aureus KW - Enterococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Staphylococcus KW - Staphylococcaceae KW - Bacillales KW - bacterial infections KW - bacterioses KW - bacterium KW - hospital infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003804&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leptospirosis. AU - Vinetz, J. M. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1997/// VL - 10 IS - 5 SP - 357 EP - 361 SN - 0951-7375 AD - Vinetz, J. M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19982006347. Publication Type: Journal Article. Language: English. Number of References: 30 ref. N2 - This review focuses on recent developments in the epidemiology, clinical manifestations, pathogenesis, pathophysiology, taxonomy and diagnosis of leptospirosis, with a brief mention of current therapeutics and directions for vaccine development. KW - animal diseases KW - bacterial diseases KW - clinical aspects KW - diagnosis KW - drug therapy KW - epidemiology KW - human diseases KW - leptospirosis KW - pathogenesis KW - physiopathology KW - reviews KW - taxonomy KW - vaccine development KW - zoonoses KW - Leptospira KW - man KW - Leptospiraceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - chemotherapy KW - clinical picture KW - pathophysiology KW - systematics KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006347&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Potential new antifungal agents. AU - Groll, A. H. AU - Walsh, T. J. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1997/// VL - 10 IS - 6 SP - 449 EP - 458 SN - 0951-7375 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201878. Publication Type: Journal Article. Language: English. Number of References: 129 ref. Registry Number: 1400-61-9, 79404-91-4, 137234-62-9. N2 - Potential new antifungal agents are discussed including third generation azoles (voriconazole, SCH 56592), echinocandins and pneumocandins (cilofungin, LY 303366, L-743872), pradimicins and benanomicins, liposomal nystatin and nikkomycin Z. New emerging compounds and targets for drugs are also considered. KW - antifungal agents KW - azoles KW - cilofungin KW - echinocandins KW - liposomes KW - nystatin KW - pharmacodynamics KW - reviews KW - voriconazole KW - benanomicins KW - ceratocide KW - drug action KW - fungistats KW - L-743872 KW - LY 303366 KW - mechanism of drug action KW - nikkomycin Z KW - pneumocandins KW - pradimicins KW - SCH 56592 KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201878&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens. AU - Brouwers, P. AU - Hendricks, M. AU - Lietzau, J. A. AU - Pluda, J. M. AU - Mitsuya, H. AU - Broder, S. AU - Yarchoan, R. JO - AIDS JF - AIDS Y1 - 1997/// VL - 11 IS - 1 SP - 59 EP - 66 SN - 0269-9370 AD - Brouwers, P.: The HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972001600. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 69655-05-6, 30516-87-1. N2 - In this non-blinded clinical trial 38 patients with symptomatic HIV-1 disease, of whom 21 had evidence of CNS compromise at entry, were randomly assigned to alternating and simultaneous regimens of zidovudine and didanosine. After 12 weeks of therapy, overall significant improvements in memory and focused attention were seen on both regimens. These gains, however, were largely limited to those patients with HIV-1-associated CNS compromise at entry. Improvements were also noted in receptive vocabulary, reading, perceptual discrimination and reasoning, divided attention, motor strength, and in mood and affect. Improvements in those latter functions were generally of limited magnitude and were of comparable size for both compromised and non-compromised patients. There was no overall difference between the two drug regimens in the effects on CNS parameters. This supports the contention that the CNS constitutes a relatively independent compartment in terms of HIV disease and treatment. KW - acquired immune deficiency syndrome KW - AIDS dementia complex KW - antiviral agents KW - central nervous system KW - clinical aspects KW - combination therapy KW - didanosine KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - nervous system diseases KW - nucleosides KW - patients KW - regimens KW - symptoms KW - treatment KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - chemotherapy KW - clinical picture KW - CNS KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - multimodal treatment KW - neuropathy KW - neuropsychology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001600&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Early foscarnet failure in herpes simplex virus infection in a patient with AIDS. AU - Segal, B. H. AU - Engler, H. D. AU - Little, R. AU - Wilson, W. H. AU - Freifeld, A. G. AU - Chanock, S. J. T2 - AIDS JO - AIDS JF - AIDS Y1 - 1997/// VL - 11 IS - 4 SP - 552 EP - 553 SN - 0269-9370 AD - Segal, B. H.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19972003482. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 63585-09-1. N2 - This report describes a case of early treatment failure of foscarnet, in which new oral mucosal HSV-1 disease developed in a patient with AIDS within one week of starting high-dose foscarnet induction therapy for cytomegalovirus disease, despite in vitro susceptibility of the HSV isolate. KW - acquired immune deficiency syndrome KW - antiviral agents KW - case reports KW - drug resistance KW - drug therapy KW - foscarnet sodium KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - treatment KW - cytomegalovirus KW - Human herpesvirus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - herpes simplex virus 1 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - trisodium phosphonoformate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003482&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunologic and virologic evaluation after influenza vaccination of HIV-1-infected patients. AU - Fowke, K. R. AU - D'Amico, R. AU - Chernoff, D. N. AU - Pottage, J. C., Jr. AU - Benson, C. A. AU - Sha, B. E. AU - Kessler, H. A. AU - Landay, A. L. AU - Shearer, G. M. JO - AIDS JF - AIDS Y1 - 1997/// VL - 11 IS - 8 SP - 1013 EP - 1021 SN - 0269-9370 AD - Fowke, K. R.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 4B17 Building 10, 9000 Rockville Pike, Bethesda MD 20892, USA. N1 - Accession Number: 19972005235. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 63231-63-0. N2 - The present study was designed to determine the effect of immune activation, achieved by influenza vaccination, on plasma HIV RNA levels and immunological parameters including CD4 cell levels, antigen-stimulated T-cell function and apoptotic death of peripheral blood mononuclear cells. Thirty four HIV-infected individuals and nine uninfected controls were immunized with influenza vaccine and blood was collected at weeks 0, 2, 4, and 16. Plasma was isolated and used for HIV RNA and influenza-specific antibody quantifications. CD4 cell counts, activation and maturation markers of T-lymphocyte subsets were determined by flow cytometry. In vitro T-helper responses, spontaneous- and activation-induced cell death assays were also performed. Influenza-specific humoral and cellular immune responses correlated with CD4 count. Only in patients with CD4 counts >300 × 106/l there was a modest increase in T-cell responses to influenza virus, which was less than control subjects, observed after vaccination. Immunization had no significant effect on CD4 counts or plasma viral levels in the HIV-positive patients. Baseline apoptosis inversely correlated with CD4 counts and directly correlated with viral load. Activation-induced apoptosis did not change appreciably after vaccination and spontaneous apoptosis increased only in the <300 CD4 group. These results indicate that immune stimulation resulting from influenza vaccination did not significantly change the levels of plasma virus, CD4 cell counts, or activation-induced apoptosis in HIV-infected individuals, although an increase in the T-cell response to influenza and spontaneous apoptosis was observed in the >300 and <300 CD4 groups, respectively. KW - antibodies KW - apoptosis KW - blood plasma KW - CD4 antigens KW - CD4+ lymphocytes KW - cell mediated immunity KW - death KW - effects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - humoral immunity KW - immune response KW - immunization KW - immunology KW - immunostimulation KW - in vitro KW - influenza KW - leukocyte count KW - maturation KW - patients KW - responses KW - RNA KW - stimulation KW - T lymphocytes KW - vaccination KW - vaccines KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - CD4+ cells KW - cell count KW - cellular immunity KW - flu KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - plasma (blood) KW - ribonucleic acid KW - T cells KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Receptive and expressive language function of children with symptomatic HIV infection and relationship with disease parameters: a longitudinal 24-month follow-up study. AU - Wolters, P. L. AU - Brouwers, P. AU - Civitello, L. AU - Moss, H. A. JO - AIDS JF - AIDS Y1 - 1997/// VL - 11 IS - 9 SP - 1135 EP - 1144 SN - 0269-9370 AD - Wolters, P. L.: National Cancer Institute, HIV/AIDS Malignancy Branch, 10 Center Drive, Building 10, 13N240, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19972005837. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - Children with symptomatic HIV infection were administered an age-appropriate standardized comprehensive language test and general cognitive measure prior to starting antiretroviral therapy (n=44) and again after 6 months (n=29) and 24 months (n=17). CD4 percentage and CT brain scans were also obtained at each evaluation. Expressive language was significantly more impaired than receptive language at the baseline, 6- and 24-month evaluations. No significant changes over time were found in receptive or expressive language from baseline to after 6 months of antiretroviral therapy, but despite treatment, language scores declined significantly between 6 and 24 months. Overall cognitive function, however, remained stable from baseline to 24 months. Age-adjusted CD4 percentage increased significantly over the initial 6 months, then remained stable. Overall CT brain scan severity ratings did not change significantly over 24 months. Expressive language was consistently more impaired than receptive language over 24 months, further supporting an earlier finding that expressive language was differentially affected by HIV in children with symptomatic disease. Both receptive and expressive language declined significantly after 24 months despite antiretroviral therapy, although overall cognitive function remained stable. Thus, functioning in some domains may be more vulnerable to the effects of HIV and global measures of cognitive ability may mask such differential changes in specific brain functions. KW - acquired immune deficiency syndrome KW - antiviral agents KW - CD4 antigens KW - children KW - clinical aspects KW - cognitive development KW - computed tomography KW - differential diagnosis KW - follow up KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - languages KW - paediatrics KW - relationships KW - speech KW - symptoms KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4 KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - mental development KW - pediatrics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does umbilical cord blood polymerase chain reaction positivity indicate in utero (pre-labor) HIV infection? AU - Biggar, R. J. AU - Mtimavalye, L. AU - Justesen, A. AU - Broadhead, R. AU - Miley, W. AU - Waters, D. AU - Goedert, J. J. AU - Chiphangwi, J. D. AU - Taha, T. E. AU - Miotti, P. G. JO - AIDS JF - AIDS Y1 - 1997/// VL - 11 IS - 11 SP - 1375 EP - 1382 SN - 0269-9370 AD - Biggar, R. J.: Department of Obstetrics and Gynaecology, Queen Elizabeth Central Hospital, Blantyre, Malawi. Correspondence address: Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Blvd, Rockville, MD 20850, USA. N1 - Accession Number: 19972007761. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Tropical Diseases N2 - In 1994, infants born to HIV-infected women were enrolled in a study in Blantyre, Malawi. Birth weight and transmission risk factors from cord blood-positive infants were compared with cord blood-negative/HIV-positive infants on their first postnatal visit (4-7 weeks of age). Testing for HIV DNA on cord and peripheral blood was performed by polymerase chain reaction. Of 249 HIV-infected infants (overall transmission rate, 26%), 83 (33%) were cord blood-positive and 166 were initially cord blood-negative. The mean birth weight was 2.1% (59 g) lighter in cord blood-positive infants than initially cord blood-negative infants; initially cord blood-negative infants were 2.8% (80 g) lighter than uninfected infants born to HIV-infected women. There were no significant differences in the risk factors for infection between HIV-infected cord blood-positive and -negative infants; when transmission was increased, both HIV-infected cord blood-positive and -negative infants contributed to the increase in a similar proportion. It was concluded that umbilical cord blood positivity for HIV DNA did not identify a subset of in utero HIV-infected infants and suggested that HIV-infected cord blood-positive and -negative infants have similar timing and routes of HIV infection. KW - cord blood KW - diagnosis KW - DNA KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - infection KW - infections KW - maternal transmission KW - mothers KW - polymerase chain reaction KW - pregnancy KW - risk factors KW - transmission KW - women KW - Africa KW - Malawi KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - deoxyribonucleic acid KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - Nyasaland KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of serum level of some biological markers in normal bilharzial infected and patients with different types of cancer. AU - El-Houseini, M. E. AU - Abu-El-Zahaub, H. S. H. AU - Moharram, N. Z. AU - Amr, M. M. AU - El-Meniawy, F. A. JO - Journal of Tumor Marker Oncology JF - Journal of Tumor Marker Oncology Y1 - 1997/// VL - 12 IS - 2 SP - 141 EP - 148 AD - El-Houseini, M. E.: Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 19980802564. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 51-35-4, 9039-53-6. Subject Subsets: Helminthology N2 - Different proteolytic enzymes, including acid protease, collagenase and plasminogen activator, showed highly significant increases in serum levels in schistosomiasis and bladder, liver and breast cancer patients compared with healthy controls. A significant increase in hydroxyproline level was also found in the serum of bilharziasis and bladder, liver and breast cancer patients as compared to normal controls. The increases were greatest in liver and breast cancer patients but were also present to a lesser extent in bladder cancer and schistosomiasis patients. KW - breast cancer KW - disease markers KW - enzymes KW - helminths KW - human diseases KW - hydroxyproline KW - liver cancer KW - neoplasms KW - parasites KW - pathology KW - plasminogen activator KW - proteinases KW - schistosomiasis KW - serum KW - Egypt KW - man KW - Schistosoma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - bilharzia KW - bilharziasis KW - cancers KW - Misr KW - oxyproline KW - parasitic worms KW - proteases KW - schistosomosis KW - Strigeida KW - urokinase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802564&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The need for assays predictive of protection in development of malaria bloodstage vaccines. AU - Miller, L. H. AU - Good, M. F. AU - Kaslow, D. C. JO - Parasitology Today JF - Parasitology Today Y1 - 1997/// VL - 13 IS - 2 SP - 46 EP - 47 AD - Miller, L. H.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980800642. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology N2 - Essential criteria for a successful vaccine against bloodstages of Plasmodium, and studies carried out in laboratory animals are briefly discussed. The problem of deciding when to proceed to human trials is then considered and the need for in vitro assays which correlate with protective immunity is stressed. KW - assays KW - clinical trials KW - erythrocytic stages KW - field tests KW - human diseases KW - immunity KW - immunization KW - in vitro KW - malaria KW - parasites KW - vaccine development KW - vaccines KW - man KW - Plasmodium KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800642&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Primary prevention of NIDDM: a practical reality. AU - Bennett, P. H. JO - Diabetes/Metabolism Reviews JF - Diabetes/Metabolism Reviews Y1 - 1997/// VL - 13 IS - 2 SP - 105 EP - 111 SN - 0742-4221 AD - Bennett, P. H.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, USA. N1 - Accession Number: 19971412424. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - This paper reviews the aetiology of non-insulin-dependent diabetes mellitus (NIDDM); the natural history of NIDDM; the development of NIDDM; the target populations of NIDDM prevention; evidence in favour of preventive measures; evidence for primary prevention; pharmacological intervention; and rationale for primary prevention of NIDDM. KW - aetiology KW - diabetes KW - prevention KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - causal agents KW - etiology KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412424&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The pathogenesis of chorioretinal disease in onchocerciasis. AU - Cooper, P. J. AU - Guderian, R. H. AU - Proaño, R. AU - Taylor, D. W. JO - Parasitology Today JF - Parasitology Today Y1 - 1997/// VL - 13 IS - 3 SP - 94 EP - 98 AD - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19970804182. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Helminthology N2 - The pathogenesis of onchocercal chorioretinopathy is reviewed under the headings: clinical pattern of chorioretinopathy; histology; epidemiology; possible pathogenic mechanisms (microfilariae in the retina and choroid, toxic secretions, autoimmunity, immune complex disease, ischaemic atrophy, nutritional factors, genetics). KW - eyes KW - helminths KW - human diseases KW - onchocerciasis KW - parasites KW - pathogenesis KW - pathology KW - retinopathy KW - reviews KW - man KW - Nematoda KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - chorioretinopathy KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804182&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reactivation of HIV type 1 in chronically infected chimpanzees following xenostimulation with human cells or with pulses of corticosteroid. AU - Shibata, R. AU - Siemon, C. AU - Rizvi, T. A. AU - Matano, T. AU - Satterfield, W. C. AU - Lane, H. C. AU - Martin, M. A. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1997/// VL - 13 IS - 5 SP - 377 EP - 381 SN - 0889-2229 AD - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972004574. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - The administration of high-dose, 17-day courses of corticosteroids resulted in coordinate and transient increases of each of the 3 virus strains present in the original inoculum and elevation of HIV-1-specific ELISA antibody levels. Steroids administered to a second chimpanzee, chronically infected with a single HIV-1 isolate, also induced elevations of cell-associated virus. These results highlight the intimate relationship between immune system activation/immunosuppression and HIV replication in an animal model. KW - animal models KW - antibodies KW - corticoids KW - ELISA KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - immunopathology KW - relationships KW - replication KW - steroids KW - chimpanzees KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Pan KW - Pongidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency viruses KW - corticosteroids KW - enzyme linked immunosorbent assay KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004574&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased in vitro tetanus-induced production of HIV type 1 following in vivo immunization of HIV type 1-infected individuals with tetanus toxoid. AU - Ostrowski, M. A. AU - Stanley, S. K. AU - Justement, J. S. AU - Gantt, K. AU - Goletti, D. AU - Fauci, A. S. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1997/// VL - 13 IS - 6 SP - 473 EP - 480 SN - 0889-2229 AD - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19972004669. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 308079-78-9. N2 - It has been previously demonstrated that immunization of HIV-1 infected individuals with the common recall antigen, tetanus, induced transient increases in plasma viraemia as well as an increased ability to isolate virus from CD8+ T cell-depleted peripheral blood mononuclear cells (PBMCs) under minimally stimulated culture conditions (IL-2 plus IL-4) postimmunization. In this study, HIV-1-infected individuals were immunized with tetanus toxoid and PBMCs were examined at multiple time points following immunization. Tetanus-induced production of virus was defined as an increased ability to isolate HIV-1 from CD8+ T cell-depleted PBMCs in vitro in the presence of tetanus antigen as opposed to no antigen or control antigen alone. Following immunization, in vitro tetanus-induced production of HIV-1 was observed in 8 of 13 (62%) patients compared to 2 of 13 (15%) patients prior to immunization. In 4 of these patients, virus could also be isolated from CD8+ T cell-depleted PBMCs in the presence of tetanus without the addition of any exogenous IL-2. Furthermore, virus could be isolated from the unfractionated PBMCs of 2 patients when tetanus antigen alone was added to the culture in the absence of added PHA or PHA blasts. HIV-1 was isolated predominantly from CD4+ T cells with a CD45RO+, CD25+ phenotype and was associated with a trend to elevated levels in culture supernatants of IFN-γ, IL-6, TNF-α, and IL-4. These findings have important implications with regard to the role of ongoing antigen-specific immune responses in the induction of HIV-1 expression in vivo. KW - antigens KW - blood plasma KW - CD4+ lymphocytes KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunization KW - immunology KW - in vitro KW - interleukins KW - patients KW - phenotypes KW - tetanus KW - toxoids KW - tumour necrosis factor KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - cachectin KW - cachexin KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - lockjaw KW - plasma (blood) KW - T4 lymphocytes KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004669&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preliminary evidence for partial restoration of immune function in HIV type 1 infection with potent antiretroviral therapies: clues from the Fourth Conference on Retroviruses and Opportunistic Diseases. AU - Schnittman, S. M. AU - Fox, L. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1997/// VL - 13 IS - 10 SP - 815 EP - 818 SN - 0889-2229 AD - Schnittman, S. M.: Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Solar Bldg./2C22, 6003 Executive Blvd., Rockville, MD 20852-3823, USA. N1 - Accession Number: 19972006871. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 13 ref. N2 - The results of studies of potent antiretroviral combination therapies presented at the 4th Conference on Retroviruses and Opportunistic Infections held in Washington, D.C., USA, between 22 and 26 January, 1997, demonstrate that such therapies are capable of at least partially restoring the immune system that is damaged by infection with HIV-1. This includes evidence for the ability of potent therapies to begin to reverse the abnormalities of maturation, activation, and function that are attributable directly or indirectly to the CD4+ helper T lymphocyte population. KW - abnormalities KW - acquired immune deficiency syndrome KW - antiviral agents KW - human diseases KW - human immunodeficiency viruses KW - infection KW - infections KW - lymphocytes KW - opportunistic infections KW - T lymphocytes KW - USA KW - Washington KW - Human immunodeficiency virus 1 KW - man KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006871&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of human immunodeficiency virus and colony-stimulating factors on the production of interleukin 6 and tumor necrosis factor α by monocyte/macrophages. AU - Foli, A. AU - Saville, M. W. AU - May, L. T. AU - Webb, D. S. A. AU - Yarchoan, R. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1997/// VL - 13 IS - 10 SP - 829 EP - 839 SN - 0889-2229 AD - Foli, A.: Correspondence address [Yarchoan, R.] Bldg 10, Rm 12N226, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006873. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Registry Number: 308079-78-9. N2 - It was observed that, in the absence of endotoxin or cytokines, monocyte/macrophages (M/Ms) productively infected by HIV do not produce detectable interleukin 6 (IL-6) or tumour necrosis factor-α (TNF-α). However, granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that enhances HIV replication in M/Ms and is frequently used to propagate monocytotropic strains of HIV, can induce the relatively long-term production of IL-6 (up to 47 U/ml) and TNF-α (up to 47 pg/ml) by M/Ms, even in the absence of HIV. Also, HIV induced production of a relatively small (≤9 U/ml) quantity of IL-6 in M/Ms stimulated with macrophage-colony stimulating factor (M-CSF). Finally, while highly concentrated HIV induced production of both cytokines by either M/Ms or peripheral blood mononuclear cells (PBMCs), this production was almost completely eliminated when care was taken to avoid contamination of HIV by endotoxin. These data suggest that the excess IL-6 and TNF-α in HIV-infected patients does not simply result from their production by HIV-infected M/Ms and that alternative mechanisms are involved in this process. KW - colony stimulating factor KW - contamination KW - cytokines KW - endotoxins KW - human immunodeficiency viruses KW - immunology KW - interleukin 6 KW - interleukins KW - necrosis KW - patients KW - replication KW - strains KW - tumour necrosis factor KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - cachectin KW - cachexin KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - long term KW - mechanisms KW - mononuclear cells KW - peripheral blood KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006873&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery. AU - Rey-Ferro, M. AU - Castaño, R. AU - Orozco, O. AU - Serna, A. AU - Moreno, A. JO - Nutrition JF - Nutrition Y1 - 1997/// VL - 13 IS - 10 SP - 878 EP - 881 AD - Rey-Ferro, M.: Gastrointestinal Surgery and Endoscopy Program, National Cancer Institute, Universidad Nacional, Santafé de Bogotá, Colombia. N1 - Accession Number: 19981401009. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - Blood samples were taken before and 5 days after surgery from 22 men and 18 women aged 54±14 years with gastric cancer at the National Cancer Institute in Bogotá, Colombia. Mononuclear cell typing was done by flow cytometry allowing a bicolor analysis. Nutritional evaluation was obtained through measurement of albumin levels, average weight loss and nutritional risk index (NRI). Half of the malignancies were localized to the middle and lower third of the stomach: stage I, 17.55%; stage II, 10%; stage III, 55%; and stage IV, 17.5%. 20 subtotal gastrectomies, 11 total gastrectomies, 7 gastrojejunostomies and 2 oesophagogastrectomies with D1 and D2-D3 lymph node resection were performed. A postoperative morbidity of 22.5% and a mortality of 7.5% were observed. A preoperative cellular immunosuppression was identified, with a helper lymphocyte (CD4) to suppressor/cytotoxic lymphocyte (CD8) ratio of 1.38 normal value (NV>1.5), which increased according to the stage of the disease. Patients who died presented with a significantly greater preoperative cellular immunosuppression than those who survived. Postoperative mortality correlated significantly with hypoalbuminemia. In those who died, weight loss was greater [not significant] than in those who survived. Patients with severe malnutrition had greater postoperative mortality according to the NRI. It is concluded that severe preoperative cellular immunosuppression (CD4/CD8 <1), hypoalbuminaemia, weight loss and severe NRI have a positive predictive value for mortality in patients with gastric cancer. KW - gastrectomy KW - immune competence KW - immune response KW - malnutrition KW - morbidity KW - mortality KW - neoplasms KW - nutritional state KW - serum albumin KW - stomach KW - surgery KW - weight losses KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - death rate KW - immunity reactions KW - immunocompetence KW - immunological competence KW - immunological reactions KW - nutritional status KW - stomach removal KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401009&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIVsmmpbj14. AU - Lori, F. AU - Gallo, R. C. AU - Malykh, A. AU - Cara, A. AU - Romano, J. AU - Markham, P. AU - Franchini, G. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1997/// VL - 13 IS - 13 SP - 1083 EP - 1088 SN - 0889-2229 AD - Lori, F.: Basic Research Laboratory, National Cancer Institute, 37 Convent Drive, Bldg 37, Rm. 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008649. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 69655-05-6, 127-07-1, 63231-63-0. N2 - It has been previously reported that hydroxyurea (HU) displays anti-HIV-1 activity and potentiates the antiviral effects of didanosine (ddI) in vitro. To assess the antiviral efficacy of HU in an animal model, the effects of HU and ddI, either individually or as combination therapy, were tested in a model using infection of pigtail macaque with the acutely fatal variant SIVsmmpbj14. At the high dosage used (100 mg/kg/day), HU monotherapy failed to protect the exposed animals from viral infection and death, which occurred within 10 days postinoculation. However, both of the ddI-treated animals (5 mg/kg/day) survived the SIVsmmpbj14 lethal dose and displayed a reduction in viral load (undetectable SIV RNA or p27gag) in the primary phase of infection. Of the animals treated with the combination of drugs, one died at day 18 after infection and failed to seroconvert to viral antigens. These data suggest that a high dose of HU monotherapy does not protect against death induced by SIVsmmpbj14. However, lower doses of HU as monotherapy or combination therapy deserve further evaluation for their therapeutic effects. KW - antiviral agents KW - antiviral properties KW - combination therapy KW - didanosine KW - drug therapy KW - experimental infections KW - hydroxycarbamide KW - laboratory animals KW - RNA KW - treatment KW - viral load KW - Human immunodeficiency virus 1 KW - Macaca KW - simian immunodeficiency virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anti-viral properties KW - chemotherapy KW - combined modality therapy KW - dideoxyinosine KW - human immunodeficiency virus type 1 KW - hydroxyurea KW - multimodal treatment KW - ribonucleic acid KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008649&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Blood collection on filter paper: a practical approach to sample collection for studies of perinatal HIV transmission. AU - Biggar, R. J. AU - Miley, W. AU - Miotti, P. AU - Taha, T. E. AU - Butcher, A. AU - Spadoro, J. AU - Waters, D. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1997/// VL - 14 IS - 4 SP - 368 EP - 373 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, EPN-434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19972004528. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - In this study, 15 810 filter paper cards with dried blood spots were collected. Infants were seen at age 6 and 12 weeks, and PCR was routinely done in duplicate on each sample. Of 186 negative controls (infants born to HIV-negative women), 2 (1.1%) had a single strongly reactive PCR result; the repeated duplicates were both negative. In contrast, all 24 known positive samples were strongly positive in both tests. Results were available from 1976 duplicate tests on 1235 infants born to HIV-infected women. Based on the PCR result on a later sample, the positive predictive value was 97.6% if both replicates were strongly positive (absorbance: 0.8 OD450U), 100% when one of the replicates was strongly positive, and 27% when one or both replicates were weakly positive (but none strongly positive). When both replicates were negative, the negative predictive value was ≥96.2%. Thus, when a single HIV PCR test has a strongly positive result, the infant is very likely to be infected. A positive PCR result after age 1 month was 98.9% accurate in predicting antibody positivity after 15 months. KW - antibodies KW - blood specimen collection KW - diagnosis KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - laboratory methods KW - maternal transmission KW - polymerase chain reaction KW - techniques KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - filter paper KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - laboratory techniques KW - mother to child transmission KW - PCR KW - positive predictive value KW - predictive value KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004528&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sexual behavior and injection drug use during pregnancy and vertical transmission of HIV-1. AU - Bulterys, M. AU - Landesman, S. AU - Burns, D. N. AU - Rubinstein, A. AU - Goedert, J. J. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1997/// VL - 15 IS - 1 SP - 76 EP - 82 AD - Bulterys, M.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA. Correspondence address [Bulterys, M.]: University of New Mexico School of Medicine, 2400 Tucker, NE, FPC Rm 149, Albuquerque, NM 87131-5267, USA. N1 - Accession Number: 19972006902. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5, 561-27-3. N2 - Maternal sexual behaviour and injecting drug use practices were evaluated as possible risk factors for vertical transmission of HIV-1. Data were analysed from the Mothers and Infants Cohort Study, a prospective study in Brooklyn and the Bronx, New York, USA. A total of 207 mother-infant sets were enrolled between 1986 and 1991 and followed for up to 4 years after the enrolment visit during pregnancy. HIV-1 transmission occurred in 49 of 201 mother-infant sets, yielding an overall transmission rate of 24.4% (95% confidence interval (CI) = 18.7% to 31.0%). Increased frequency of vaginal intercourse after the first trimester of pregnancy was positively associated with vertical transmission of HIV-1 (trend P = 0.03). A lifetime history of injecting drug use was not associated with vertical transmission. However, a history of combined cocaine and heroin injection after the first trimester of pregnancy was associated with vertical HIV-1 transmission, particularly among women with CD4+ lymphocyte levels of 20% or higher (risk ratio = 4.0; 95% CI = 2.0 to 8.1). Cocaine and heroin injecting drug use after the first trimester accounted for most of the relation between preterm birth and vertical HIV-1 transmission in this cohort. Maternal coinfection with hepatitis C virus or human T-cell lymphotropic virus types I and II could not explain these observations because coinfection with these viruses had no detectable effect on HIV-1 transmission. These results suggest that maternal sexual behaviour and injection drug use practices during the second and third trimester of pregnancy may modify the risk of vertical HIV-1 transmission. KW - cocaine KW - drug abuse KW - effects KW - hepatitis KW - hepatitis C KW - heroin KW - infants KW - injecting drug abuse KW - injecting drug users KW - injection KW - maternal transmission KW - mixed infections KW - mothers KW - pregnancy KW - risk factors KW - sexual behaviour KW - sexual intercourse KW - T lymphocytes KW - transmission KW - vagina KW - vertical transmission KW - women KW - New York KW - USA KW - Deltaretrovirus KW - Human immunodeficiency virus 1 KW - human T-cell lymphotropic virus KW - man KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - diacetylmorphine KW - diamorphine KW - drug use KW - gestation KW - HTLV-BLV group KW - human immunodeficiency virus type 1 KW - i.v. drug abuse KW - i.v. drug abusers KW - i.v. drug use KW - i.v. drug users KW - intravenous drug users KW - mother to child transmission KW - multiple infections KW - sexual behavior KW - sexual practices KW - sexuality KW - T cells KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis C virus diagnostics: technology, clinical applications and impacts. AU - Conry-Cantilena, C. JO - Trends in Biotechnology JF - Trends in Biotechnology Y1 - 1997/// VL - 15 IS - 2 SP - 71 EP - 76 SN - 0167-7799 AD - Conry-Cantilena, C.: Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982000555. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health N2 - This review firstly considers the evaluation of hepatitis C virus (HCV) infection by biochemistry and serology, covering biochemical evidence of liver disease and indirect measures of infection, serological assays, first- and second-generation antibody screening assays and third-generation anti-HCV assays. It then addresses viral detection by molecular methods: detection and quantitation of HCV RNA, genotype determination and the future of molecular testing for HCV. KW - antibody testing KW - applications KW - assays KW - biochemistry KW - genotypes KW - hepatitis C KW - human diseases KW - identification KW - liver KW - reviews KW - serology KW - techniques KW - technology KW - viral diseases KW - viral hepatitis KW - hepatitis C virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antibody detection KW - antibody tests KW - viral infections KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000555&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Survival after AIDS diagnosis in a cohort of hemophilia patients. AU - Gail, M. H. AU - Tan W.-Y. AU - Pee, D. AU - Goedert, J. J. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1997/// VL - 15 IS - 5 SP - 363 EP - 369 AD - Gail, M. H.: National Cancer Institute, Executive Plaza North, Room 431, 6130 Executive Boulevard, MSC 7368, Bethesda, MD 20892-7368, USA. N1 - Accession Number: 19972010745. Publication Type: Journal Article. Corporate Author: Multicenter Hemophilia Cohort Study Language: English. Number of References: 17 ref. N2 - This study investigated factors affecting survival after the diagnosis of AIDS in a cohort of 1253 patients with haemophilia. The nature of the AIDS-defining condition was found to be as important as age at seroconversion and CD4+ lymphocyte level in predicting survival. A multivariate analysis yielded estimates of median survival for groups defined by age at seroconversion (0 through 15, 16 through 69), CD4+ lymphocyte count (<100 cells/µl versus ≥100 cells/µl), and 10 AIDS-defining disease groups. Estimates of median survival after a single AIDS-defining condition ranged from 3 to 51 months, depending on the diseases. Median survival after a second AIDS-defining condition was about 1.5 to 2.0-fold shorter than after an initial, isolated AIDS-defining condition. HIV-related neurological disease (i.e. AIDS dementia complex or multifocal leukoencephalopathy) was a notable exception. It correlated with the shortest estimates of median survival (3 to 9 months), and this poor prognosis was no worse for patients who had a second AIDS-defining condition. The results of this analysis were consistent in most respects with other published analyses of factors affecting survival. These findings may be useful in the clinical care of persons with AIDS and in estimating the number of persons alive who have had a particular AIDS-defining disease. KW - acquired immune deficiency syndrome KW - AIDS dementia complex KW - clinical aspects KW - diagnosis KW - disease course KW - haemophilia KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphocytes KW - patients KW - prognosis KW - seroconversion KW - survival KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - clinical picture KW - disease progression KW - hemophilia KW - HUMAN IMMUNODEFICIENCY VIRUS KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Predictors and impact of patients lost to follow-up in a long-term randomized trial of immediate versus deferred antiretroviral treatment. AU - Ioannidis, J. P. A. AU - Bassett, R. AU - Hughes, M. D. AU - Volberding, P. A. AU - Sacks, H. S. AU - Lau, J. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1997/// VL - 16 IS - 1 SP - 22 EP - 30 AD - Ioannidis, J. P. A.: HIV Research Branch, Therapeutics Research Program, Divison of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building, Room 2C15, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010825. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 30516-87-1. N2 - Predictors for losses to follow-up and the impact of such losses were studied in the AIDS Clinical Trials Group 019 protocol, a long-term randomized trial of immediate versus deferred antiretroviral therapy in asymptomatic HIV-1-infected patients with >500 CD4 cells/µl. The trial was selected because it had the longest follow-up among all antiretroviral trials and the largest percentage of patients whose vital status was unknown at study end. Younger age, a history of parenteral drug use, and nonwhite race were associated with higher rates of loss to follow-up, but race was not an important predictor after adjusting for clinical site. There was large and statistically significant variability in the rates of losses among different clinical sites (P<0.001). Patient retention was significantly better in clinical sites that enrolled many participants, with 25% of enrollees lost to follow-up in sites enrolling >100 patients and 44% in sites enrolling <33 patients each. As a group, patients lost to follow-up after the second year had steeper declines of CD4 cell counts, and a significantly larger proportion had reached a CD4 cell count <300/µl in the year before being lost, compared with patients remaining in the study. Losses to follow-up probably decreased substantially the observed number of primary endpoints, curtailed the power of the trial to demonstrate any difference between immediate and deferred initiation of antiretroviral therapy, and may have introduced large bias in the estimated hazard ratio for the primary endpoint and its statistical significance. KW - acquired immune deficiency syndrome KW - antiviral agents KW - asymptomatic infections KW - CD4 antigens KW - CD4+ lymphocytes KW - clinical aspects KW - clinical trials KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - leukocyte count KW - patients KW - statistical analysis KW - treatment KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - CD4 KW - CD4+ cells KW - cell count KW - chemotherapy KW - clinical picture KW - HUMAN IMMUNODEFICIENCY VIRUS KW - human immunodeficiency virus infections KW - statistical methods KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010825&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pradimicins: a novel class of broad-spectrum antifungal compounds. AU - Walsh, T. J. AU - Giri, N. JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1997/// VL - 16 IS - 1 SP - 93 EP - 97 SN - 0934-9723 AD - Walsh, T. J.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971200513. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Pradimicins are discussed, including structure and structure-function relationship, mechanism of action, in vitro antifungal activity, in vitro antiviral activity, in vivo antifungal activity and toxicity. KW - antifungal agents KW - antifungal properties KW - antiviral properties KW - drug therapy KW - drug toxicity KW - fungicides KW - pharmacodynamics KW - structure KW - structure activity relationships KW - therapy KW - anti-fungal properties KW - anti-viral properties KW - chemotherapy KW - drug action KW - fungicidal properties KW - fungistats KW - mechanism of drug action KW - pradimicins KW - therapeutics KW - Trends in invasive fungal infections KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200513&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive aspergillosis in human immunodeficiency virus-infected children. AU - Shetty, D. AU - Giri, N. AU - Gonzalez, C. E. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1997/// VL - 16 IS - 2 SP - 216 EP - 221 SN - 0891-3668 AD - Shetty, D.: Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971202040. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology; Public Health N2 - The records of 473 HIV-infected children followed in the Pediatric Branch of the National Cancer Institute in the USA during 1987-95 were reviewed for the presence of Aspergillus infection. Seven (1.5%) patients developed invasive aspergillosis during the study period. Causative organisms were A. fumigatus (3 cases), A. glaucus (1) and Aspergillus sp. (3). All patients had low CD4+ counts reflecting severe immunosuppression. Sustained neutropenia (>7 days) or corticosteroid therapy as a predisposing factor for invasive aspergillosis was encountered in only 2 patients (28%). Invasive pulmonary aspergillosis developed in 5 patients and cutaneous aspergillosis in 2. The most common presenting features in patients with pulmonary aspergillosis were fever, cough and dyspnoea. Patients with cutaneous aspergillosis were diagnosed during life and successfully treated with amphotericin B and surgery, whereas diagnosis of pulmonary aspergillosis was made clinically in only 1 patient. It is concluded that aspergillosis is an uncommon but highly lethal opportunistic infection in HIV-infected children. KW - acquired immune deficiency syndrome KW - amphotericin B KW - aspergillosis KW - children KW - clinical aspects KW - epidemiology KW - hiv infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - mycoses KW - opportunistic infections KW - predisposition KW - North America KW - USA KW - Aspergillus KW - Aspergillus fumigatus KW - Eurotium herbariorum KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Eurotium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - Aspergillus glaucus KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971202040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytomegalovirus infection in children with human immunodeficiency virus infection. AU - Kitchen, B. J. AU - Engler, H. D. AU - Gill, V. J. AU - Marshall, D. AU - Steinberg, S. M. AU - Pizzo, P. A. AU - Mueller, B. U. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1997/// VL - 16 IS - 4 SP - 358 EP - 363 SN - 0891-3668 AD - Kitchen, B. J.: Pediatric Branch, National Cancer Institute, 10 Center Drive, Bethesda, MD, USA. N1 - Accession Number: 19972005456. Publication Type: Journal Article. Language: English. Number of References: 27 ref. N2 - To determine the prevalence of positive cytomegalovirus (CMV) cultures in paediatric patients with HIV infection, the case records of 273 HIV-infected children referred to the Pediatric Branch of the National Cancer Institute, USA, for whom CMV cultures were performed during January 1991-October 1994, were reviewed. Of this group, 189 patients (69%) had negative CMV cultures and 84 (31%) had positive cultures. The prevalence of CMV-related disease was 9% for the entire group, including 4 (2.1%) patients with negative CMV cultures. Among the 84 patients with positive CMV cultures, 21 (25%) had evidence of CMV disease. Patients with positive CMV cultures had a statistically significant decrease in survival in the presence of severe immunocompromise defined as an age-corrected CD4+ count of <21%. Of 35 postmortem examinations performed, 9 (26%) demonstrated evidence of CMV disease, including 7 patients with disseminated CMV disease. It is concluded that although CMV disease appears to be less frequent in children than adults, CMV infection still contributes significantly to morbidity and mortality in this population, especially when combined with severe immunosuppression. KW - CD4 antigens KW - CD4+ lymphocytes KW - children KW - clinical aspects KW - disseminated infections KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infection KW - leukocyte count KW - mortality KW - opportunistic infections KW - patients KW - survival KW - viral diseases KW - USA KW - Cytomegalovirus KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - CD4 KW - CD4+ cells KW - cell count KW - clinical picture KW - death rate KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T4 lymphocytes KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005456&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fatal Nocardia pulmonary infection in a child with acquired immunodeficiency syndrome and lymphoid interstitial pneumonitis. AU - Zwerski, S. AU - Witebsky, F. G. AU - Conville, P. S. AU - Gill, V. J. AU - Freifeld, A. G. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1997/// VL - 16 IS - 11 SP - 1088 EP - 1089 SN - 0891-3668 AD - Zwerski, S.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981200442. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 9-year-old boy from Maryland, USA, with vertically-acquired HIV infection and a 7-year history of progressive bilateral interstitial infiltrates presumed to be due to lymphoid interstitial pneumonitis (LIP), who presented in 1996 with exacerbation of LIP. Histological examination of bronchoalveolar lavage samples revealed long branching organisms consistent with Nocardia and cultures grew Nocardia sp. Chest computed tomography demonstrated consolidation and multiple cavities with possible bronchiectasis in the left lower lobe. Despite administration of trimethoprim sulfamethoxazole and antibiotics the patient's condition deteriorated, with increasing pulmonary insufficiency and he died of cardiac failure 3 months later. KW - acquired immune deficiency syndrome KW - boys KW - case reports KW - children KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - lungs KW - nocardiosis KW - opportunistic infections KW - pneumonitis KW - Maryland KW - USA KW - man KW - Nocardia KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nocardiaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterium KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - sulfamethoxazole trimethoprim KW - trimethoprim sulfamethoxazole KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200442&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration. AU - Wei ShuiQing AU - Mizuuchi, K. AU - Craigie, R. JO - EMBO Journal JF - EMBO Journal Y1 - 1997/// VL - 16 IS - 24 SP - 7511 EP - 7520 SN - 0261-4189 AD - Wei ShuiQing: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982002792. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9007-49-2. N2 - The nucleoprotein organization of Moloney murine leukaemia virus (MLV) pre-integration complexes was probed using a novel footprinting technique that utilizes a simplified in vitro phage Mu transposition system. It was found that several hundred base pairs at each end of the viral DNA are organized in a large nucleoprotein complex, which were termed the intasome. This structure is not formed when pre-integration complexes are made by infecting cells with integrase-minus virus, demonstrating a requirement for integrase. In contrast, footprinting of internal regions of the viral DNA did not reveal sigificant differences between pre-integration complexes with and without integrase. Treatment with high salt disrupts the intasome in parallel with loss of intermolecular integration activity. It was shown that a cellular factor is required for reconstitution of the intasome. Finally, it was demonstrated that DNA-protein interactions involving extensive regions at the ends of the viral DNA are functionally important for retroviral DNA integration activity. Current in vitro integration systems utilizing purified integrase lack the full fidelity of the in vivo reaction. These results indicate that both host factors and long viral DNA substrates may be required to reconstitute an in vitro system with all the hallmarks of DNA integration in vivo. KW - DNA KW - hosts KW - human diseases KW - in vitro KW - integration KW - interactions KW - leukaemia KW - nucleoproteins KW - replication KW - structure KW - substrates KW - systems KW - transposition KW - treatment KW - viral replication KW - Human immunodeficiency virus 1 KW - Murine leukemia virus KW - Retroviridae KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Gammaretrovirus KW - blood cancer KW - deoxyribonucleic acid KW - gene transposition KW - human immunodeficiency virus type 1 KW - leucaemia KW - leukemia KW - murine leukaemia virus KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002792&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An approach to estimating exposure-specific rates of breast cancer from a two-stage case-control study within a cohort. AU - Benichou, J. AU - Byrne, C. AU - Gail, M. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1997/// VL - 16 IS - 1/3 SP - 133 EP - 151 SN - 0277-6715 AD - Benichou, J.: National Cancer Institute, Biostatistics Branch, 6130 Executive Blvd, EPN/403, MSC 7368, Bethesda, MD 20892-7368, USA. N1 - Accession Number: 19972005745. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health N2 - The Breast Cancer Detection and Demonstration Project (BCDDP) included a cohort of >280 000 women followed for incidence of breast cancer for 5 years. These women volunteered to enrol in 29 centres in the USA between 1973 and 1980. An initial case-control sample (n = 3000) was drawn and standard risk factors obtained. In order to study the effect of mammographical features on breast cancer risk, a nested subsample of cases and controls was drawn. These data can be viewed as 2-stage case-control data within a cohort, or as cohort data with 2 nested levels of missingness, since basic characteristics like age were measured on all members of the cohort, standard risk factors were elicited only in the initial case-control sample, and mammographical features were assessed only in the nested subsample of cases and controls. A Poisson pseudo-likelihood approach to estimating age- and exposure-specific breast cancer incidence rates based on the 3 types of variables is presented. This approach takes into account the nested missingness as well as 2 other types of missingness, namely, that for basic variables and standard risk factors, some levels were omitted by design in the nested subsample of case and controls or were empty because of the sparsity of the data in that subsample. Estimates of standard errors are obtained from a parametric bootstrap. The approach is concluded to be efficient when applied to the BCDDP data and to be flexible for modelling breast cancer rates and taking the special missingness features of these data into account. KW - breast KW - breast cancer KW - epidemiology KW - estimation KW - neoplasms KW - risk factors KW - volunteers KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary change as a strategy for preventing cancer. AU - Schatzkin, A. JO - Cancer and Metastasis Reviews JF - Cancer and Metastasis Reviews Y1 - 1997/// VL - 16 IS - 3/4 SP - 377 EP - 392 SN - 0167-7659 AD - Schatzkin, A.: National Cancer Institute, Rockville Pike, Bethesda, Maryland, USA. N1 - Accession Number: 19981407172. Publication Type: Journal Article. Language: English. Number of References: 93 ref. Subject Subsets: Human Nutrition KW - aetiology KW - breast KW - colon KW - diet KW - mortality KW - neoplasms KW - nutrition KW - prevention KW - prostate KW - rectum KW - breasts KW - cancers KW - causal agents KW - death rate KW - etiology KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407172&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacometric analysis of the effect of furosemide on suramin pharmacokinetics. AU - Piscitelli, S. C. AU - Forrest, A. AU - Lush, R. M. AU - Ryan, N. AU - Whitfield, L. R. AU - Figg, W. D. JO - Pharmacotherapy JF - Pharmacotherapy Y1 - 1997/// VL - 17 IS - 3 SP - 431 EP - 437 SN - 0277-0008 AD - Piscitelli, S. C.: Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19970806209. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 54-31-9, 145-63-1. Subject Subsets: Protozoology N2 - The effects of furosemide on the pharmacokinetics of suramin were investigated in a group of 27 patients who were receiving the drug for cancer therapy. The patients received suramin by continuous or intermittent infusion with and without concomitant furosemide. Optimum suramin regimens were achieved by adaptive feedback control, and pharmacokinetic data were collected both in the presence and absence of furosemide. Suramin concentrations were determined by HLPC and were fit to a 3-compartment linear model with 6 coefficients and 2 rate inputs, which allowed furosemide to affect suramin pharmacokinetics. Individual and population parameter estimates were determined using the interactive 2-stage approach. Concomitant furosemide was associated with a median decrease in total body clearance of suramin by 36% (range 0-63%, p<0.001). No other parameter was significantly altered and there was no trend for change in any pharmacokinetic value with time. Suramin plasma concentrations were simulated with and without prolonged furosemide therapy in 26 patients for 12 weeks. The average suramin concentration increased by >33% in 12 patients; 2 patients had a >67% increase in this extreme case model. It was concluded that co-administration of furosemide with suramin can cause an increase in suramin concentrations; however, due to the long half-life of suramin, its rate of accumulation is very slow. KW - antiprotozoal agents KW - blood plasma KW - drug combinations KW - furosemide KW - parasites KW - pharmacokinetics KW - suramin KW - trypanocides KW - man KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - plasma (blood) KW - trypanocidal drugs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970806209&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Physical and functional interaction between the human T-cell lymphotropic virus type 1 tax protein and the CCAAT binding protein NF-Y. AU - PiseMasison, C. A. AU - Dittmer, J. AU - Clemens, K. E. AU - Brady, J. N. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1997/// VL - 17 IS - 3 SP - 1236 EP - 1243 SN - 0270-7306 AD - PiseMasison, C. A.: Virus Tumor Biology Section, Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA. N1 - Accession Number: 19972007918. Publication Type: Journal Article. Language: English. Number of References: 93 ref. Registry Number: 9007-49-2, 70-18-8. N2 - Tax1, a potent activator of human T-cell lymphotropic virus type 1 (HTLV-1) transcription, has been shown to modulate expression of many cellular genes. Tax1 does not bind DNA directly but regulates transcription through protein-protein interactions with sequence-specific transcription factors. Using the yeast two-hybrid system to screen for proteins which interact with Tax1, we isolated the B subunit of the CCAAT binding protein NF-Y from a HeLa cDNA library. The interaction of Tax1 with NF-YB was specific in that NF-YB did not interact with a variety of other transcription factors, including human immunodeficiency virus Tat, human papillomavirus E6, and Bicoid, or with the M7 (amino acids 29CP-AS) Tax1 mutant. However, NF-YB did interact with the C-terminal Tax1 mutants M22 (130TL-AS) and M47 (319LL-RS). We also show that in vitrotranslated NF-YB specifically bound to a glutathione S-transferase-Tax1 fusion protein. Further, Tax1 coimmunoprecipitated with NF-Y from nuclear extracts of HTLV-1-transformed cells, providing evidence for in vivo interaction of Tax1 and NF-YB. We further demonstrate that Tax1 specifically activated the NF-Y-responsive DQΒ promoter, as well as a minimal promoter which contains only the Y-box element. In addition, mutation of the Y-box element alone abrogated Tax1-mediated activation. Taken together, these data indicate that Tax1 interacts with NF-Y through the B subunit and that this interaction results in activation of the major histocompatibility complex class II promoter. Through activation of this and other NF-Y driven promoters, the Tax1-NF-Y interaction may play a critical role in causing cellular transformation and HTLV-1 pathogenesis. KW - acquired immune deficiency syndrome KW - bacterial toxins KW - complementary DNA KW - DNA KW - extracts KW - glutathione KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - major histocompatibility complex KW - mutants KW - mutations KW - promoters KW - proteins KW - T lymphocytes KW - transcription KW - yeasts KW - Deltaretrovirus KW - human papillomaviruses KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - fungi KW - eukaryotes KW - Papillomaviridae KW - dsDNA Viruses KW - DNA Viruses KW - Deltaretrovirus KW - Human T-cell lymphotropic virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Papillomavirus KW - AIDS KW - B subunit KW - cDNA KW - deoxyribonucleic acid KW - DNA transcription KW - fungus KW - histocompatibility complex KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human papillomavirus KW - Papovaviridae KW - promoter region KW - promoter sequences KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007918&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary restriction mitigates ozone-induced lung inflammation in rats: a role for endogenous antioxidants. AU - Kari, F. AU - Hatch, G. AU - Slade, R. AU - Crissman, K. AU - Simeonova, P. P. AU - Luster, M. JO - American Journal of Respiratory Cell and Molecular Biology JF - American Journal of Respiratory Cell and Molecular Biology Y1 - 1997/// VL - 17 IS - 6 SP - 740 EP - 747 SN - 1044-1549 AD - Kari, F.: Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 19981415442. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 59-02-9, 70-18-8, 10028-15-6. Subject Subsets: Human Nutrition N2 - Male F344 rats were fed NIH-31 diet ad libitum (n=10) or restricted at 75% of ad libitum intake (n=10). After 3 weeks of dietary adaptation, rats were exposed by inhalation to 2.0 mg/kg ozone (O3) for 2 h or chamber air and evaluated for cellular and biochemical indices of pulmonary toxicity. Compared with air controls, bronchoalveolar lavage fluid (BALF) from O3 exposed ad libitum fed rats contained increased protein (145 vs. 380 µg/ml), polymorphonuclear cell (PMN) infiltration (0 vs. 11%) and fibronectin (45 versus 607 U/ml). Diet restriction abrogated these indicators of pulmonary inflammation induced by ozone. Binding of 18O3 to BALF protein and cells was significantly decreased in diet restricted rats while BALF ascorbate and glutathione levels, but not α-tocopherol or urate, were increased compared with ad libitum fed rats. It is concluded that dietary restriction affords protection against O3-induced oxidant toxicity. Protection is mediated partially by increases in ascorbate in the fluid bathing the lung surface, thereby providing an antioxidant sink which minimizes the ability of O3 to reach biological targets. KW - alpha-tocopherol KW - antioxidants KW - fibronectins KW - food restriction KW - glutathione KW - inflammation KW - lungs KW - ozone KW - restricted feeding KW - toxicity KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415442&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emerging parasitic infections. AU - James, S. L. JO - FEMS Immunology and Medical Microbiology JF - FEMS Immunology and Medical Microbiology Y1 - 1997/// VL - 18 IS - 4 SP - 313 EP - 317 SN - 0928-8244 AD - James, S. L.: Division of Microbiology and Infectious Diseases, NIAID, National Institutes of Health, Solar Building, Room 3A10, 6003 Executive Boulevard, Bethesda, MD 20892, USA. N1 - Accession Number: 19980806212. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Helminthology N2 - This review of emerging and re-emerging parasitic diseases briefly discusses Cryptosporidium, Cyclospora, Enterocytozoon bieneusi, Septata intestinalis, Isospora belli, Toxoplasma gondii, Acanthamoeba, Babesia microti, Baylisascaris procyonis, Leishmania, Echinococcus multilocularis, Trypanosoma cruzi and Taenia solium, particularly with regard to the USA, and AIDS-related immunosuppression. KW - emerging infectious diseases KW - helminths KW - human diseases KW - immunocompromised hosts KW - parasites KW - parasitoses KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - emerging diseases KW - emerging infections KW - parasitic diseases KW - parasitic infestations KW - parasitic worms KW - parasitosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806212&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The relationship between study design, results, and reporting of randomized clinical trials of HIV infection. AU - Ioannidis, J. P. A. AU - Cappelleri, J. C. AU - Sacks, H. S. AU - Lau, J. JO - Controlled Clinical Trials JF - Controlled Clinical Trials Y1 - 1997/// VL - 18 IS - 5 SP - 431 EP - 444 SN - 0197-2456 AD - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Building Room 2C15, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010702. Publication Type: Journal Article; Annual report; Journal article. Language: English. Number of References: 25 ref. Registry Number: 30516-87-1. N2 - The purpose of this study was to examine whether the study design of randomized clinical trials for medications against HIV may affect the results and whether the outcomes of these trials affect reporting and publication. A database of 71 published randomized HIV-related drug efficacy trials was used and the following study design factors were considered: endpoint definition and method of analysis, masked design, sample size, and duration of follow-up. The study revealed that design factors may have an impact on the magnitude and significance of the treatment effect in HIV-related trials. Bias in reporting can further affect the information that these studies provide. Compared with trials published in specialized journals, trials published in journals of wide readership were larger (P = 0.001) and 4.4 times more likely to report "positive" results (P = 0.01). Several samples of trials with "negative" results that have remained unpublished for a long time were identified. KW - clinical aspects KW - clinical trials KW - databases KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - information KW - publications KW - relationships KW - research KW - survival KW - treatment KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - clinical picture KW - data banks KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010702&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The human health effects of DDT (dichlorodiphenyl-trichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines in public health. AU - Longnecker, M. P. AU - Rogan, W. J. AU - Lucier, G. JO - Annual Review of Public Health JF - Annual Review of Public Health Y1 - 1997/// VL - 18 SP - 211 EP - 244 SN - 0163-7525 AD - Longnecker, M. P.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. N1 - Accession Number: 19971109335. Publication Type: Journal Article. Language: English. Number of References: 7 pp. of ref. Registry Number: 50-29-3. Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology N2 - A review of data cited in the 1991-95 Medline database and elsewhere showed that high-level exposure to selected organochlorines (including DDT) in man appears to cause abnormal functioning of the liver, skin (chloracne) and nervous system. Of more general interest, however, was evidence suggesting insidious effects of background exposure. Of particular concern was the finding of neonatal hypotonia or hyporeflexia in relation to exposure to polychlorinated biphenyls (PCBs). The epidemiological data reviewed, considered in isolation, provided no convincing evidence that organochlorines cause a large excess number of cancers. A recent risk assessment that considered animal data, however, gave a cancer risk estimate for background exposure to dioxin and dioxin-like compounds (e.g. some PCBs) with an upper limit in the range of 10-4 per year. KW - agricultural entomology KW - DDT KW - insecticides KW - liver KW - neoplasms KW - nervous system KW - nontarget effects KW - organochlorine pesticides KW - pesticides KW - polychlorinated biphenyls KW - reviews KW - skin KW - toxicity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - dermis KW - dicophane KW - organic chlorine pesticides KW - PCBs KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971109335&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunologic aspects of osteoporosis. AU - Ershler, W. B. AU - Harman, S. M. AU - Keller, E. T. JO - Developmental and Comparative Immunology JF - Developmental and Comparative Immunology Y1 - 1997/// VL - 21 IS - 6 SP - 487 EP - 487 SN - 0145-305X AD - Ershler, W. B.: Gerontologic Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. N1 - Accession Number: 19981407151. Publication Type: Journal Article. Language: English. Number of References: 127 ref. Subject Subsets: Human Nutrition N2 - Following a brief introduction, the risk factors of osteoporosis and as a major health concern to the geriatric population are reviewed. The role of interleukin-6 (IL-6) in the pathogenesis of osteoporosis is discussed including, the increase with age of IL-6 and receptor levels, the relationship with oestrogen and androgens, the enhancement of osteoclastogenesis and bone remodelling. Topics also discussed include: an age associated decrease of osteoblast numbers associated with age-related osteoporosis; changes in osteoclast activity as a possible contributor to age-associated osteoporosis; hormones, aging and osteoporosis; and immunsenescence, cytokines and osteoporosis. It is concluded that there is substantial support for the hypothesis that certain pro-inflammatory cytokines, such as IL-1 and IL-6, are important in the normal bone remodelling process and in the pathogenesis of post-menopausal osteoporosis. KW - aging KW - bones KW - immunology KW - interleukins KW - osteoporosis KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407151&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new 85 kDa, breast tumour associated antigen-a potential diagnostic and prognostic agent. AU - Utpala Chattopadhyay AU - Saumitra Pal JO - Journal of Biosciences JF - Journal of Biosciences Y1 - 1997/// VL - 22 IS - 1 SP - 69 EP - 75 SN - 0250-5991 AD - Utpala Chattopadhyay: Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Calcutta 700 026, India. N1 - Accession Number: 19972007433. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Tropical Diseases N2 - A breast tumour associated antigen (BTAA) was isolated from the breast tumour tissues of untreated female cancer patients in Calcutta, India. The BTAA purified by DEAE discontinuous column chromatography followed by size exclusion HPLC was an 85 kDa glycoprotein. A high level of circulating antibodies against this antigen was observed, using ELISA, in 30/30 untreated female breast cancer patients. The BTAA was not immunologically related to murine mammary tumour virus (MuMTV) antigens but strongly resembled an 83 kDa glycoprotein tumour associated antigen, purified from MuMTV induced mouse mammary tumour. In patients after surgical removal of the breast tumour (20 patients), the circulating antibodies to the BTAA decreased gradually, but reappeared in the patients with secondary metastasis. In 10 healthy age matched women and in 5 female patients with carcinoma of tissues other than breast, no significant titre of the BTAA antibodies was observed. KW - antibodies KW - antigens KW - breast KW - breast cancer KW - carcinoma KW - characterization KW - diagnosis KW - ELISA KW - human diseases KW - immunological techniques KW - neoplasms KW - purification KW - Asia KW - India KW - West Bengal KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - antigenicity KW - breasts KW - cancer sites KW - cancers KW - enzyme linked immunosorbent assay KW - immunogens KW - serological techniques KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007433&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Results of a community-based low-literacy nutrition education program. AU - Hartman, T. J. AU - McCarthy, P. R. AU - Park, R. J. AU - Schuster, E. AU - Kushi, L. H. JO - Journal of Community Health JF - Journal of Community Health Y1 - 1997/// VL - 22 IS - 5 SP - 325 EP - 341 SN - 0094-5145 AD - Hartman, T. J.: National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19981407091. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition N2 - A nutrition intervention focused on low-fat eating pattern changes was conducted among low-literacy participants in a Twin Cities Metropolitan area Expanded Food and Nutrition Education Programme (EFNEP) in the USA. A total of 134 EFNEP participants who participated in the intervention were compared to 70 comparison participants who received EFNEP nutrition education materials. Associations between changes in outcome variables specific to the intervention were evaluated using mixed-model regression analyses. The principal effects seen for this programme were related to changes in eating pattern scales. More modest effects were seen in scales related to attitudes of low-fat eating and although changes in dietary fat intake as measured by 24-h dietary interviews suggested a positive intervention effect, this did not approach significance. KW - fats KW - intake KW - nutrition education KW - nutrition programmes KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - feeding programmes KW - feeding programs KW - food programs KW - nutrition programs KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407091&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Disseminated zygomycosis in a neutropenic patient: successful treatment with amphotericin B lipid complex and granulocyte colony-stimulating factor. AU - Gonzalez, C. E. AU - Couriel, D. R. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1997/// VL - 24 IS - 2 SP - 192 EP - 196 SN - 1058-4838 AD - Gonzalez, C. E.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971200837. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 59-year-old man from Maryland, USA, who developed persistent fever during a period of neutropenia in April 1993 following treatment for aplastic anaemia. Computed tomography (CT) of the chest revealed a mass in the right upper lobe and needle aspiration was performed. Cultures of the aspirate grew Rhizomucor pusillus and the lesion was resected. Treatment with amphotericin B (1.5 mg/kg daily) and granulocyte colony-stimulating factor (G-CSF) was started. Due to deteriorating renal function, therapy was later changed to amphotericin B lipid complex (ABLC; 4 mg/kg daily) and continued for 1 month. In August 1993 the patient was readmitted with a 3-week history of fever and right upper quadrant pain. Abdominal ultrasonography revealed bilateral, hypoechoic, solid renal masses and fine needle aspiration of these yielded necrotic debris and hyphal elements. R. pusillus was cultured from the aspirate and from urine samples. Symptoms gradually resolved after treatment with intravenous ABLC (4 mg/kg daily) and G-CSF. KW - amphotericin B KW - application methods KW - case reports KW - colony stimulating factor KW - cytokines KW - generalized infections KW - hosts KW - human diseases KW - immunocompromised hosts KW - immunology KW - immunotherapy KW - infections KW - kidneys KW - lipids KW - men KW - neutropenia KW - opportunistic infections KW - predisposition KW - therapy KW - treatment KW - zygomycosis KW - Maryland KW - USA KW - man KW - Mucoraceae KW - Rhizomucor pusillus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mucorales KW - Mucoromycotina KW - Zygomycota KW - fungi KW - Rhizomucor KW - Mucoraceae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungus KW - lipins KW - phycomycosis KW - therapeutics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vaginal colonization or infection with Candida albicans in human immunodeficiency virus-infected women during pregnancy and during the postpartum period. AU - Burns, D. N. AU - Tuomala, R. AU - Chang BeiHung AU - Hershow, R. AU - Minkoff, H. AU - Rodriguez, E. AU - Zorrilla, C. AU - Hammill, H. AU - Regan, J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1997/// VL - 24 IS - 2 SP - 201 EP - 210 SN - 1058-4838 AD - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19972003063. Publication Type: Journal Article. Corporate Author: Women and Infants Transmission Study Group. Language: English. Subject Subsets: Medical & Veterinary Mycology N2 - This study evaluated the relationship between immunological status and vaginal colonization or infection with Candida albicans for 605 women from the USA, who were enrolled in a multicentre, prospective cohort study of mother-to-infant transmission of HIV-1. A low CD4+ level (<14% vs. ≥14%, which corresponds to an absolute count of approx. 200 × 106/l) was associated with a 2- to 5-fold increased likelihood of vaginal colonization (odds ratio (OR), 2.28; 95% CI 1.01-5.19) and vaginal candidosis (OR, 3.08; 95% CI, 1.21-7.71) during pregnancy and during the postpartum period (OR, 2.98; 95% CI, 1.51-5.88 and OR, 5.45; 95% CI, 1.73-16.6, respectively). These associations persisted in multivariate logistic regression analyses. No associations with CD8+ lymphocyte levels or CD8+CD38+ or other lymphocyte subset levels were found after adjustment for CD4+ cell count and other covariates. However, postpartum (but not antepartum) antibiotic use and pregnancy were also associated with vaginal colonization and candidosis (P≤0.001 for each). Vaginal candidosis was not associated with an increased risk of mother-to-infant transmission of HIV-1; however, a related more inclusive variable, clinical vaginitis, or vaginosis of any aetiology at the last antepartum visit, was associated with mother-to-infant transmission (OR, 1.92; 95% CI, 1.07-3.43). These findings emphasize the complex, multifactorial nature of vaginal candidosis and highlight the need for safe and effective treatment and prevention strategies for women with advanced HIV infection. KW - acquired immune deficiency syndrome KW - candidosis KW - colonization KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - immunological deficiency KW - immunology KW - infection KW - infections KW - maternal transmission KW - mothers KW - opportunistic infections KW - postpartum period KW - predisposition KW - pregnancy KW - risk factors KW - transmission KW - vagina KW - women KW - USA KW - candida albicans KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - candidiasis KW - fungus KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Hyphomycetes KW - immune deficiency KW - immunodeficiency KW - mother to child transmission KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003063&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. AU - Tilly, K. AU - Casjens, S. AU - Stevenson, B. AU - Bono, J. L. AU - Samuels, D. S. AU - Hogan, D. AU - Rosa, P. JO - Molecular Microbiology JF - Molecular Microbiology Y1 - 1997/// VL - 25 IS - 2 SP - 361 EP - 373 SN - 0950-382X AD - Tilly, K.: Laboratory of Microbial Structure and Function, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19980501931. Publication Type: Journal Article. Language: English. Number of References: 78 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The 26-28 kb circular plasmid of B. burgdorferi s.l. (cp26) is ubiquitous among bacteria of this group and contains loci implicated in the mouse-tick transmission cycle. Restriction mapping and Southern hybridization indicated that the structure of cp26 is conserved among isolates from different origins and culture passage histories. The cp26 ospC gene encodes an outer surface protein whose synthesis within infected ticks increases when the ticks feed, and whose synthesis in culture increases after a temperature upshift. Previous studies of ospC coding sequences showed them to have stretches of sequence apparently derived from the ospC genes of distantly related isolates by homologous recombination after DNA transfer. Conservation was found of the promoter regions of the ospC and guaA genes, which are divergently transcribed. The increase in OspC protein after a temperature upshift was shown to parallel increases in mRNA levels, as expected if regulatory regions adjoin the conserved sequences in the promoter regions. Finally, directed insertion was used to inactivate the ospC gene of a non-infectious isolate. This first example of directed gene inactivation in B. burgdorferi shows that the OspC protein is not required for stable maintenance of cp26 or growth in culture. KW - genes KW - inactivation KW - molecular genetics KW - nucleotide sequences KW - plasmids KW - temperature KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - DNA sequences KW - ospA KW - outer surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501931&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HTLV-I Tax self-association in optimal trans-activation function. AU - Jin DongYan AU - Jeang KuanTeh JO - Nucleic Acids Research JF - Nucleic Acids Research Y1 - 1997/// VL - 25 IS - 2 SP - 379 EP - 387 SN - 0305-1048 AD - Jin DongYan: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972004876. Publication Type: Journal Article. Language: English. Number of References: 64 ref. N2 - The one hybrid and two hybrid genetic approaches in yeast were used to investigate the region(s) within HTLV-I Tax necessary for self-association. Dimer formation was also confirmed biochemically by using electrophoretic mobility shift (EMSA) and supershift assays. 22 Tax point mutants were utilized to map relevant residues. Genetic results from this series of mutants revealed that a necessary region for dimerization is contained within a previously characterized zinc finger domain. Two loss-of-function Tax mutants, each poorly active when assayed individually were found to have complementing activity when co-expressed together. This genetic complementation suggests a mechanism for trans-activation resulting from simultaneous but non-identical contact with a responsive target by each of 2 Tax monomers in a dimer. KW - genes KW - genetics KW - htlv-i infections KW - human diseases KW - mutants KW - tax protein KW - transcription KW - viral regulatory proteins KW - Deltaretrovirus KW - human t-cell lymphotropic virus type i KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - DNA transcription KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004876&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Decay rates of anti-HIV dideoxynucleotides in tissue culture systems: a simple correction for the effect of cell replication. AU - Ahluwaia, G. S. AU - Dedrick, R. L. AU - Driscoll, J. S. AU - Morrison, P. F. AU - Gao WenYi AU - Johns, D. G. JO - Drug Metabolism and Disposition JF - Drug Metabolism and Disposition Y1 - 1997/// VL - 25 IS - 7 SP - 893 EP - 896 SN - 0090-9556 AD - Ahluwaia, G. S.: Correspondence address [Burnes, D. G.]: Building 37, Rm 5B22, Laboratory of Medicinal Chemstry, Division of Basic Sciences, National Cancer Institute/NIH, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972007176. Publication Type: Journal Article. Language: English. Number of References: 14 ref. N2 - Measurement of intracellular drug levels in cell culture systems can be of predictive value in establishing rational clinical dosage schedules. Such in vitro measurements carried out with anti-HIV agents of the 2′,3′-dideoxynucleoside (ddN) class have shown that many of the pharmacologically active ddNTP metabolites of these agents have relatively long intracellular half-lives and little or no host-cell cytotoxicity. As a consequence, replication of drug-exposed cells continues at an unperturbed rate so that a systematic dilution error occurs in the measurement of ddNTP decay half-times. The aim of this study is to present a simple general formulation for the correction of measured t1/2-values for ddNTPs and for other agents with similar intracellular pharmacokinetic properties. Two factors of practical interest emerge: first, the error is greater for agents with slow intracellular clearance rates than for agents with rapid rates; and second, for cell lines with long doubling times, the measured t1/2-values approach more closely the true t1/2-values, until with the extreme case (quiescent or "G0" cells), the observed and true decay times are identical. The greatest dilution errors are seen with adenosine-based agents such as ddATP and 2′-F-ddATP, while the smallest errors are seen with rapidly cleared agents of the dideoxythymidine class. KW - analogues KW - antiviral agents KW - cell lines KW - clinical aspects KW - decay KW - drug therapy KW - effects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - mathematical models KW - measurement KW - metabolism KW - metabolites KW - nucleoside analogues KW - nucleosides KW - pharmacokinetics KW - replication KW - tissue culture KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - metrology KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007176&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme disease. AU - Dorward, D. W. AU - Fischer, E. R. AU - Brooks, D. M. A2 - Bosler, E. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1997/// VL - 25 IS - Suppl. 1 SP - S2 EP - S8 SN - 1058-4838 AD - Dorward, D. W.: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19980501763. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology N2 - To examine the nature and consequences of interactions between Lyme disease spirochaetes and immune effector cells, Borrelia burgdorferi s.l. was coincubated with primary and cultured human leukocytes. It was found that B. burgdorferi actively attaches to, invades, and kills human B and T lymphocytes. Significant killing began within 1 h of mixing. Cytopathic effects varied with respect to host cell lineage and the species, viability, and degree of attenuation of the spirochaetes. Both spirochaetal virulence and lymphocytic susceptibility could be phenotypically selected, thus indicating that both bacterial and host cell factors contribute to such interactions. These results suggest that invasion and lysis of lymphocytes may constitute previously unrecognized factors in Lyme disease and bacterial pathogenesis. KW - cells KW - cytopathogenicity KW - invasion KW - leukocytes KW - Lyme disease KW - lymphocytes KW - pathogenicity KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Annual international conference on Lyme borreliosis and other tick-borne diseases KW - bacterium KW - Basic and clinical approaches to Lyme disease: a Lyme Disease Foundation symposium KW - leucocytes KW - lyme borreliosis KW - white blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501763&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects on the Lyme disease spirochete. AU - Lubke, L. L. AU - Garon, C. F. A2 - Bosler, E. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1997/// VL - 25 IS - Suppl. 1 SP - S48 EP - S51 SN - 1058-4838 AD - Lubke, L. L.: Bacterial Pathogenesis Section, Rocky Mountain Laboratories Microscopy Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19980501772. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 15 ref. Registry Number: 20449-79-0. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi has demonstrated a capacity to resist the in vitro effects of powerful eukaryotic and prokaryotic metabolic inhibitors. However, treatment of laboratory cultures on Barbour-Stoenner-Kelly medium with melittin showed immediate and profound inhibitory effects when they were monitored by dark-field microscopy, field emission scanning electron microscopy, and optical density measurements. Furthermore, at melittin concentrations as low as 100 µg/ml, virtually all spirochaete motility ceased within seconds of inhibitor addition. Ultrastructural examination of these spirochaetes by scanning electron microscopy revealed obvious alterations in the surface envelope of the spirochaetes. KW - antibacterial properties KW - hive products KW - Lyme disease KW - melittin KW - scanning electron microscopy KW - toxicity KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Annual international conference on Lyme borreliosis and other tick-borne diseases KW - bactericidal properties KW - bacterium KW - Basic and clinical approaches to Lyme disease: a Lyme Disease Foundation symposium KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Apiculture (LL010) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501772&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition. AU - Tsai, H. F. AU - Washburn, R. G. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Molecular Microbiology JF - Molecular Microbiology Y1 - 1997/// VL - 26 IS - 1 SP - 175 EP - 183 SN - 0950-382X AD - Tsai, H. F.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19981201500. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9007-36-7. Subject Subsets: Medical & Veterinary Mycology N2 - Conidial colour mutants of A. fumigatus exhibited significant increases in C3 binding capacity compared with wild type. A reddish-pink mutation that led to enhanced C3 binding was complemented by a cosmid clone. A 3.3kb DNA fragment from the subsequently rescued cosmid was sufficient to restore the bluish-green conidial pigment. The bluish-green transformant exhibited a level of C3 binding similar to that of the parental strain. A gene, designated arp1, was responsible for the complementation. Comparison of the genomic and cDNA sequences of arp1 revealed that it has 2 introns and encodes a putative protein of 168 amino acids. Arp1 is very similar to scytalone dehydratase, an enzyme involved in 1,8-dihydroxynaphthalene-melanin synthesis in Colletotrichum lagenarium and Magnaporthe grisea. Northern hybridization analysis revealed that arp1 is developmentally regulated, being expressed during conidiation. Disruption of arp1 resulted in reddish-pink conidia and increased C3 binding. It is suggested that arp1 modulates the bluish-green pigmentation of conidia as well as complement deposition. KW - binding KW - complement KW - conidia KW - genes KW - mutants KW - pigmentation KW - Aspergillus fumigatus KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - complement binding KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201500&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Americans' knowledge of cancer risk and survival. AU - Breslow, R. A. AU - Sorkin, J. D. AU - Frey, C. M. AU - Kessler, L. G. JO - Preventive Medicine JF - Preventive Medicine Y1 - 1997/// VL - 26 IS - 2 SP - 170 EP - 177 SN - 0091-7435 AD - Breslow, R. A.: Applied Research Branch, National Cancer Institute, EPN-313, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19982004968. Publication Type: Journal Article. Language: English. Number of References: 25 ref. N2 - Results are given of a interview survey, completed by 12 035 individuals in 1992 in the USA as part of the National Health Interview Survey (NHIS). Respondents' knowledge of cancer risk factors and prospects of survival were determined using sex-appropriate questions and multiple-choice flash-card lists; respondents' access to medical care was also elicited. Among women, 70% correctly identified family history as a risk factor for cancer (men identified this less frequently) and age was identified as a risk factor by about 25% of the women. Only 35% of women identified multiple sexual partners as a risk factor for cervical cancer; the knowledge was particularly low among younger women. The percentage of women who identified age as a risk factor for breast and colon cancer decreased from 25-34 years and 35-44 years of age, respectively to age ≥75 years of age. For prostate cancer, the percentage of men who identified age as a risk factor increased between 35 and 44 years of age and remained at >50% to 75 years of age, the highest level of identification of age as a risk factor for any of the cancers among men or among women. Only about one-third of all respondents knew of the relationship between diet and cancer. Identification of risk factors tended to be lowest among those who were black or Hispanic, had the lowest income, the lowest education or no usual source of medical care. Demographic patterns for the proportion of respondents stating that chances of survival were good were similar to patterns for knowledge about risk factors. It is concluded that this survey emphasises the need for education about risk factors for cancer and the prospects of survival following early detection in the USA. KW - human diseases KW - knowledge KW - neoplasms KW - risk factors KW - survival KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004968&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intrauterine device use and endometrial cancer risk. AU - Sturgeon, S. R. AU - Brinton, L. A. AU - Berman, M. L. AU - Mortel, R. AU - Twiggs, L. B. AU - Barrett, R. J. AU - Wilbanks, G. D. AU - Lurain, J. R. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1997/// VL - 26 IS - 3 SP - 496 EP - 500 SN - 0300-5771 AD - Sturgeon, S. R.: Environmental Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN443, Bethesda, Maryland 20852, USA. N1 - Accession Number: 19972008473. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health N2 - The relation between use of an intrauterine device (IUD) and endometrial cancer risk was examined using data from a US multicentre case-control study involving 405 endometrial cancer cases (aged 20-74 years) identified between June 1987 and May 1990 and 297 population controls. 20 (4.9%) cases and 34 (11.4%) controls reported any use of an IUD. After adjustment for potential confounders. IUD use was not associated with an increased risk of endometrial cancer (RR=0.56 for ever use; 95% CI: 0.3-1.0). Little reduction in risk was observed among women who last used an IUD within 10 years of the index date (RR=0.84; 95% CI: 0.3-2.4) but risk was decreased among women who used an IUD in the more distant past (RR=0.45; 95% CI: 0.2-1.0). Risk did not vary consistently with number of years of IUD use or with years since first use. Risk was not increased among women who used inert devices (RR=0.46; 95% CI: 0.3-3.6) or those who used devices containing copper (RR=1.08; 95% CI: 0.1-3.6). It is concluded that these data do not provide any evidence of an increased risk of endometrial cancer among women who have used IUD. KW - contraceptives KW - endometrial cancer KW - endometrium KW - epidemiology KW - human diseases KW - intrauterine devices KW - neoplasms KW - risk factors KW - women KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancer sites KW - cancers KW - endometrial area KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008473&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission-blocking vaccines: uses and current status of development. AU - Kaslow, D. C. A2 - Andrews, R. H. JO - International Journal for Parasitology JF - International Journal for Parasitology Y1 - 1997/// VL - 27 IS - 2 SP - 183 EP - 189 SN - 0020-7519 AD - Kaslow, D. C.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970501175. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology N2 - An intensive effort to develop subunit vaccines for malaria targeted at various stages of the Plasmodium life cycle has been undertaken. One such vaccine, directed against the sexual and sporogonic stages and referred to as a transmission-blocking vaccine, offers the hope of controlling malaria in geographically isolated areas, preventing re-introduction of the parasite in malaria-free zones, blocking the spread of drug-resistant or vaccine escape mutants, and reducing exposure to "virulent" strains of parasites. A series of potential transmission-blocking vaccine candidates have been identified and the genes encoding these surface proteins have now been isolated and sequenced. One such vaccine candidate, Pfs25, is now being tested in human Phase I safety and immunogenicity studies. Here, the use and status of transmission-blocking vaccines are reviewed. KW - antigens KW - disease transmission KW - disease vectors KW - gametes KW - gametocytes KW - human diseases KW - malaria KW - oocysts KW - ookinetes KW - parasites KW - reviews KW - transmission blocking antibodies KW - transmission blocking immunity KW - vaccines KW - zygotes KW - Anopheles KW - Culicidae KW - Diptera KW - man KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Plasmodium KW - antigenicity KW - Australian and New Zealand Societies for Parasitology Scientific Meeting KW - immunogens KW - mosquitoes KW - transmission blocking vaccines KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501175&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trends in food intake: the 1987 and 1992 national health interview surveys. AU - Breslow, R. A. AU - Subar, A. F. AU - Patterson, B. H. AU - Block, G. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1997/// VL - 28 IS - 1 SP - 86 EP - 92 SN - 0163-5581 AD - Breslow, R. A.: Applied Research Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20001412819. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - To examine food intake trends in the US population, cross-sectional nationally representative food intake data were obtained from the 1987 and 1992 National Health Interview Survey Cancer Control Supplements. In each of these years, approximately 10 000 respondents completed methodologically consistent food frequency questionnaires containing the same 57 food items. Between 1987 and 1992, the proportion of Americans consuming high-fat foods, including fried fish, fried chicken, bacon, eggs, whole milk, and butter, decreased. The proportion of Americans drinking alcoholic beverages also decreased: fewer drank wine and hard liquor in 1992. The proportion of fruit and vegetable consumers remained stable over time. These results are similar to those obtained from more detailed national surveys. National guidelines urge Americans to avoid intake of high-fat foods, increase consumption of fruits and vegetables, and practice moderation when drinking alcoholic beverages to prevent cancer and other chronic diseases. The direction of Americans' apparent changes in food usage between 1987 and 1992, evaluated using limited data from food frequency questionnaires, suggests greater behavioural changes in the direction of guidelines recommending avoidance of foods that may increase the risk of cancer than in the direction of guidelines recommending increased consumption of foods that may confer protection. KW - alcoholic beverages KW - bacon KW - behavioural changes KW - beverages KW - butter KW - consumption KW - diet studies KW - dietary surveys KW - distilled spirits KW - eggs KW - food consumption KW - food intake KW - foods KW - fried foods KW - fruits KW - milk KW - milk consumption KW - vegetables KW - wines KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - behavior change KW - drinks KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Milk and Dairy Produce (QQ010) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular phylogeny of the genus Entamoeba as revealed by riboprinting. AU - Clark, C. G. AU - Diamond, L. S. JO - Archives of Medical Research JF - Archives of Medical Research Y1 - 1997/// VL - 28 IS - Special Issue SP - S69 EP - S70 SN - 0066-6769 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19970802424. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology KW - amoebiasis KW - genes KW - human diseases KW - molecular genetics KW - molecular taxonomy KW - parasites KW - phylogeny KW - Entamoeba KW - protozoa KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - amebiasis KW - biochemical genetics KW - small subunit ribosomal RNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802424&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cholesterol requirement and metabolism in Entamoeba histolytica. AU - Luján, H. D. AU - Diamond, L. S. JO - Archives of Medical Research JF - Archives of Medical Research Y1 - 1997/// VL - 28 IS - Special Issue SP - S96 EP - S97 SN - 0066-6769 AD - Luján, H. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892-045, USA. N1 - Accession Number: 19970802436. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 5 ref. Registry Number: 57-88-5. Subject Subsets: Protozoology KW - amoebiasis KW - biochemistry KW - cholesterol KW - cholesterol metabolism KW - human diseases KW - parasites KW - Entamoeba histolytica KW - protozoa KW - Entamoeba KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - amebiasis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802436&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. AU - Cott, J. M. A2 - Müller, W. E. A2 - Kaper, S. JO - Pharmacopsychiatry JF - Pharmacopsychiatry Y1 - 1997/// VL - 30 IS - SUP 2 SP - 108 EP - 112 AD - Cott, J. M.: National Institute of Mental Health (NIMH), 5600 Fishers Lane, Room 18-105, Rockville, Maryland 20857, USA. N1 - Accession Number: 19980308154. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Subject Subsets: Horticultural Science N2 - Hypericum perforatum (St. John's wort) has been used since the time of ancient Greece for its many medicinal properties. Modern usage is still quite diverse and includes promotion of wound healing, and treatment of kidney and lung ailments, insomnia and depression. This plant has been known to contain a red pigment, hypericin, and similar compounds, which have been assumed to be the primary active constituent(s). A crude Hypericum extract was tested in a battery of 39 in vitro receptor assays, and 2 enzyme assays. A sample of pure hypericin was also tested. Hypericin had affinity only for NMDA receptors while the crude extract had significant receptor affinity for adenosine (nonspecific), GABAA, GABAB, benzodiazepine, inositol triphosphate and monoamine oxidase A and B. With the exception of GABAA and GABAB, the concentrations of Hypericum extract required for these in vitro activities were unlikely to be attained after oral administration to animals or man. These data are consistent with recent pharmacologic evidence suggesting that other constituents of this plant may be of greater importance for the reported psychotherapeutic activity. Alternative pharmacologic mechanisms for Hypericum's antidepressant activity are critically reviewed and the possible importance of GABA receptor binding in the pharmacology of Hypericum is highlighted. KW - enzyme activity KW - enzymes KW - herbal drugs KW - medicinal plants KW - medicinal properties KW - nervous system KW - pharmacology KW - plant composition KW - plant extracts KW - receptors KW - Hypericum perforatum KW - Hypericum KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - chemical constituents of plants KW - drug plants KW - herbal medicines KW - Hypericum extract (LI 160) as a herbal antidepressant KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980308154&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of exercise training in a cold environment on thermoregulation in adult and aged C57BL/6J mice. AU - Shefer, V. I. AU - Talan, M. I. JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1997/// VL - 32 IS - 6 SP - 695 EP - 705 SN - 0531-5565 AD - Shefer, V. I.: Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA. N1 - Accession Number: 19981407636. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - The effect of exercise training in cold environment (six weeks of daily, one-hour runs on a treadmill at ambient temperature of 6 ± 1°C at 60-65% of VO2max) on cold-induced metabolic heat production, heat loss, and cold tolerance was studied in adult and aged C57BL/6J male mice. The training resulted in greater cold-induced heat production and cold tolerance without changes in heat loss, similar to the effects of daily cold exposure without exercise. In aged mice, daily cold exposures did not affect cold tolerance and cold-induced heat production, but exercise training in the cold resulted in greater cold-induced heat production and cold tolerance. Heat loss in aged mice increased similarly after both repeated cold exposures and exercise training in the cold. Therefore, mechanisms of effect of exercise training on cold tolerance are different in adult and aged animals. Exercise training in cold environment does not affect cold-induced heat production and cold tolerance in adult mice, but improves them in aged animals. KW - aging KW - body temperature KW - cold KW - cold resistance KW - cold tolerance KW - elderly KW - energy exchange KW - environmental temperature KW - exercise KW - heat loss KW - heat production KW - heat retention KW - old age KW - physical activity KW - training KW - man KW - rats KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - aged KW - ageing KW - calorigenesis KW - cold hardiness KW - elderly people KW - older adults KW - senior citizens KW - thermogenesis KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407636&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Proceeding of the second international conference on animal models for aging research, Kyoto, Japan, 12-19 May, 1995. A2 - Sprott, R. L. A2 - Takeda, T. A2 - Rocha, C. A. T2 - Experimental Gerontology JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1997/// VL - 32 IS - 1/2 SP - 1 EP - 242 SN - 0531-5565 AD - Biology of Aging Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave., Gateway Bldg., Rm. 2C231, Bethesda, MD 20892, USA. N1 - Accession Number: 19971408987. Publication Type: Conference proceedings. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition N2 - This special double issue contains 23 papers that were presented at the conference entitled: biogerontologic theories; genetic influences on aging; comparative aging with life histories in mammals; experimental design and husbandry; prospects for quantitative trait locus methodology in gerontology; issues in the choice of genetic configuration for animal aging models; selection for maximum longevity in mice; mouse and rat genotype choices; biomarkers of age and aging; expression of endothelin, fibronectin, and mortalin as aging and mortality markers; senescence-accelerated mouse (SAM): a novel murine model of senescence; management and design of the maintenance of SAM strains: an animal model for accelerated senescence and age-associated disorders; pathobiology of the SAM; genetic characterization of SAM; characteristics of age-related behavioral changes in SAMP8 and SAMP10; beneficial effects of aged garlic extract on learning and memory impairment in the SAM; neuropathological studies on strains of SAM with age-related deficits in learning and memory; effect of acidic fibroblast growth factor on basal forebrain cholergic neurons in SAM; immune abnormality in relation to non-immune diseases in SAM; in vitro study of the mechanisms of senescence acceleration; diet and calorie restriction; pathobiology of aging rodents: inbred and hybrid models; and herbal medicine and the study of aging in SAM (SAMP1TA/Ngs). The 16th and 21st papers are abstracted elsewhere in this issue of NAR/A. KW - age KW - aging KW - animal models KW - brain KW - diet KW - energy deprivation KW - experimental design KW - extracts KW - garlic KW - genetics KW - geriatrics KW - growth factors KW - immunity KW - learning KW - longevity KW - markers KW - medicinal plants KW - memory KW - models KW - mortality KW - neurons KW - selection KW - Allium sativum KW - mammals KW - mice KW - Allium KW - Alliaceae KW - Liliaceae KW - Liliales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - vertebrates KW - Chordata KW - animals KW - Muridae KW - rodents KW - mammals KW - ageing KW - cerebrum KW - death rate KW - drug plants KW - gerontology KW - medicinal herbs KW - nerve cells KW - neurones KW - officinal plants KW - plot design KW - second international conference on animal models for aging research KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408987&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet and calorie restriction. AU - Sprott, R. L. A2 - Sprott, R. L. A2 - Takeda, T. A2 - Rocha, C. A. JO - Experimental Gerontology JF - Experimental Gerontology Y1 - 1997/// VL - 32 IS - 1/2 SP - 205 EP - 214 SN - 0531-5565 AD - Sprott, R. L.: The Biology of Aging Program, The National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave., Gateway Bldg., Suite 2C231, Bethesda, Maryland 20892 USA. N1 - Accession Number: 19971408915. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition N2 - This paper briefly reviews on the effects of energy restriction on a variety of functional measures and on age-dependent tumours and lesions. The effects of energy restriction on the probability of survival and mean body weight of C57BL/6N, DBA/2N, B6xD2F1 and B6xC3F1 mice and F344, Brown Norway and F344xBN rats of both sexes are presented graphically. Recommendations for energy restriction, or at least "dietary control," are discussed. KW - aging KW - animal models KW - body weight KW - energy deprivation KW - models KW - reviews KW - sex differences KW - survival KW - mice KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - second international conference on animal models for aging research KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408915&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay. AU - Tobin, G. J. AU - Ennis, W. H. AU - Clanton, D. J. AU - Gonda, M. A. JO - Antiviral Research JF - Antiviral Research Y1 - 1997/// VL - 33 IS - 1 SP - 21 EP - 31 SN - 0166-3542 AD - Tobin, G. J.: Laboratory of Cell and Molecular Structure, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001493. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9007-49-2. N2 - A cell culture-based antiviral assay was developed to test compounds for inhibition of BIV replication. The assay uses an embryonic rabbit epithelial (EREp) cell line that is highly sensitive to BIV infection and cytopathology. The 50% effective concentrations (EC50) at which the virus was inhibited in EREp cells were determined for 13 nucleoside analogue, non-nucleoside, tumour-suppressive, or membrane-surface inhibitory compounds. The nucleoside analogues (3′-azido-2′,3′-dideoxythymidine, 2′,3′-dideoxyinosine and 2′,3′-dideoxycytosine), surface-membrane inhibitors (dextran sulfate, hypericin, Chicago Sky Blue and quinobene), the nucleoside reductase inhibitor (hydroxyurea), and a tumour-suppressive phorbol ester (prostratin) inhibited BIV with EC50 values similar to those derived in HIV-1 lymphocyte (CD4+)-based assays. BIV was markedly more resistant to inhibition with HIV-1-specific non-nucleoside reverse transcriptase inhibitors (NNRTIs) (thiazolobenzimidazole, oxathiin carboxanilide and thiocarbamate) than was HIV-1, which parallels results with NNRTIs in HIV-2 assays. KW - analogues KW - antiviral agents KW - cell lines KW - DNA KW - enzyme inhibitors KW - genomes KW - hiv infections KW - human diseases KW - inhibition KW - inhibitors KW - lymphocytes KW - microbiology KW - nucleoside analogues KW - nucleosides KW - nucleotide sequences KW - replication KW - resistance KW - reverse transcriptase inhibitors KW - bovine immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - Lentivirus KW - rabbits KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - deoxyribonucleic acid KW - DNA sequences KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - non-nucleoside reverse transcriptase inhibitors KW - nucleoside analogs KW - other Retroviridae KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001493&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV). AU - Gulakowski, R. J. AU - McMahon, J. B. AU - Buckheit, R. W. Jr. AU - Gustafson, K. R. AU - Boyd, M. R. JO - Antiviral Research JF - Antiviral Research Y1 - 1997/// VL - 33 IS - 2 SP - 87 EP - 97 SN - 0166-3542 AD - Gulakowski, R. J.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972002642. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9026-43-1, 9068-38-6. N2 - Prostratin inhibited HIV-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression in two latently-infected cell lines, but had little or no effect on chronically-infected cell lines. Prostratin caused a dose-dependent, but reversible, decrease in CD4 expression in the CEM-SS and MT-2 cell lines. This down-regulation of CD4 was inhibited in a dose-dependent manner by the protein kinase C (PKC) antagonist, staurosporine. Prostratin had no effect on reverse transcriptase or HIV-1 protease, nor did it inhibit the binding of gp120 to CD4. KW - antiviral agents KW - CD4 antigens KW - cytopathogenicity KW - effects KW - envelope protein gp120 KW - esters KW - HIV-1 infections KW - hosts KW - human diseases KW - kinases KW - microbiology KW - protein kinase KW - replication KW - reverse transcriptase KW - viral replication KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - gp120 KW - human immunodeficiency virus type 1 KW - other agents KW - phorbol KW - prostratin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002642&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alcohol's impact upon glycobiology. AU - Lands, W. E. M. JO - Indian Journal of Biochemistry & Biophysics JF - Indian Journal of Biochemistry & Biophysics Y1 - 1997/// VL - 34 IS - 1/2 SP - 212 EP - 213 SN - 0301-1208 AD - Lands, W. E. M.: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, NIH, 6000 Executive Blvd MSC 7003, Bethesda MD 20892-7003, USA. N1 - Accession Number: 19981400756. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition N2 - This paper briefly reviews ways in which some of the diseases (cardiovascular diseases, liver diseases, neuropathological illness and fetal injury) linked to excessive alcohol intake may develop from alcohol-induced alterations of cell surface molecules. KW - alcoholic beverages KW - cardiovascular diseases KW - cell membranes KW - cirrhosis KW - ethanol KW - fetus KW - injuries KW - liver diseases KW - nervous system diseases KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ethyl alcohol KW - foetus KW - liver cirrhosis KW - neuropathy KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400756&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. AU - Walsh, T. J. AU - Kasai, M. AU - Francesconi, A. AU - Landsman, D. AU - Chanock, S. J. JO - Journal of Medical and Veterinary Mycology JF - Journal of Medical and Veterinary Mycology Y1 - 1997/// VL - 35 IS - 2 SP - 133 EP - 137 SN - 0268-1218 AD - Walsh, T. J.: Infectious Diseases Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971201109. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - To identify potential target sequences that may be derived from candidate genes that share homology with the ATP binding cassette region of the human MDR-1 P-glycoprotein, degenerate oligonucleotide primers based on the known sequence from the ATP binding cassette region of the human MDR-1 P-glycoprotein were used to amplify polymerase chain reaction (PCR) products within the range of 100 bp in length from C. albicans isolates (3 fluconazole-susceptible and 3 fluconazole-resistant). Sequence analysis of individually subcloned PCR products, derived from the 6 isolates revealed 34 sequences in total. The results identified 14 clones (with at least 1 per isolate) with a high degree of homology to the ATP binding cassette of the human MDR-1 P-glycoprotein. A BLAST search did not disclose homology of these new sequences to the C. albicans CDR1 gene, indicating that C. albicans may possess >1 MDR-like gene. It is concluded that C. albicans may possess one or more additional genes encoding ATP binding cassette MDR-like proteins that are distinct from CDR1 and which could participate in the development of fluconazole resistance. KW - antifungal agents KW - drug resistance KW - fluconazole KW - fungicides KW - genes KW - genetics KW - resistance KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungistats KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Absence of tetrodotoxins in a captive-raised riparian frog, Atelopus varius. AU - Daly, J. W. AU - Padgett, W. L. AU - Saunders, R. L. AU - Cover, J. F., Jr. JO - Toxicon (Oxford) JF - Toxicon (Oxford) Y1 - 1997/// VL - 35 IS - 5 SP - 705 EP - 709 SN - 0041-0101 AD - Daly, J. W.: Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010447. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases KW - physiology KW - skin KW - toxins KW - Panama KW - frogs KW - Anura KW - Amphibia KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central America KW - America KW - Developing Countries KW - Latin America KW - Threshold Countries KW - Atelopus varius KW - dermis KW - tetrodotoxins KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Laboratory diagnosis of respiratory virus infections in 24 hours by utilizing shell vial cultures. AU - Engler, H. D. AU - Preuss, J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1997/// VL - 35 IS - 8 SP - 2165 EP - 2167 SN - 0095-1137 AD - Engler, H. D.: Microbiology Service, Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1058, USA. N1 - Accession Number: 19982005384. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health N2 - During February 1995-January 1997, 603 clinical specimens from mainly immunocompromised patients at the Clinical Center of the National Institutes of Health, Bethesda, MD, USA, were submitted for respiratory virus (RV) culture. Laboratory diagnosis was performed by immunofluorescence staining of centrifugation-enhanced shell vial (SV) cultures. The procedure, which required only a 24 h incubation period, permitted the detection of 77% of the RV-positive specimens that would ordinarily not have been detected as positive until 48 h. Staining SVs at 24 h also permitted earlier detection of viruses that were missed by rapid antigen detection methods. KW - culture techniques KW - detection KW - diagnosis KW - human diseases KW - parainfluenza viruses KW - respiratory diseases KW - viral diseases KW - Maryland KW - USA KW - human adenovirus KW - human respiratory syncytial virus KW - Influenza B virus KW - influenzavirus A KW - influenzavirus B KW - man KW - Mastadenovirus KW - Adenoviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - Influenzavirus B KW - Orthomyxoviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Paramyxovirinae KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - lung diseases KW - parainfluenza virus KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005384&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of the hybrid capture tube test and PCR for detection of human papillomavirus DNA in cervical specimens. AU - Cope, J. U. AU - Hildesheim, A. AU - Schiffman, M. H. AU - Manos, M. M. AU - Lörincz, A. T. AU - Burk, R. D. AU - Glass, A. G. AU - Greer, C. AU - Buckland, J. AU - Helgesen, K. AU - Scott, D. R. AU - Sherman, M. E. AU - Kurman, R. J. AU - Liaw, K. L. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1997/// VL - 35 IS - 9 SP - 2262 EP - 2265 SN - 0095-1137 AD - Cope, J. U.: Division of Cancer Epidemiology & Genetics, National Cancer Institute, EPN Rm 439, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004682. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health N2 - Two DNA methods that are commonly used for HPV research in the USA were compared: the MY09/MY11 L1 consensus primer PCR-based test and the first-generation Hybrid Capture tube method (HCT). Laboratory assays by each method were performed with 596 cervicovaginal specimens collected from participants in a large cohort study conducted in Portland, Oregon. Included were 499 specimens from women whose cytology was normal and 97 specimens from women with squamous intraepithelial lesions (SILs). The overall HPV DNA positivity for known types was 22.5% by PCR compared to 13.6% by HCT. When the analysis was restricted to the 14 HPV types detectable by both methods, the sensitivity of HCT, with PCR used as the standard for HPV status, was higher for specimens from women with concurrent SILs (81.0%) than for specimens from women with normal cytology (46.7%). Among specimens testing positive by both methods, 97.2% of the time the two methods agreed on whether specimens were positive for cancer-associated HPV types. Both of these HPV test methods provide information that supplements the information provided by the Pap smear. In conclusion, the PCR method has higher analytic sensitivity than HCT in detecting HPV, but HCT may be helpful in identifying women with concurrent SILs. KW - assays KW - cervical cancer KW - cervix KW - detection KW - DNA KW - human diseases KW - hybrids KW - laboratory methods KW - lesions KW - methodology KW - neoplasms KW - polymerase chain reaction KW - specimens KW - women KW - USA KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Papillomaviridae KW - cancers KW - deoxyribonucleic acid KW - human papillomavirus KW - laboratory techniques KW - methods KW - Papovaviridae KW - PCR KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of commercially available and in-house reverse transcription-PCR assays for detection of hepatitis G virus or GB virus C. AU - Forns, X. AU - Tan, D. AU - Alter, H. J. AU - Purcell, R. H. AU - Bukh, J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1997/// VL - 35 IS - 10 SP - 2698 EP - 2702 SN - 0095-1137 AD - Forns, X.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Dr., MSC 0740, Bethesda, MD 20892-0740, USA. N1 - Accession Number: 19982006672. Publication Type: Journal Article. Language: English. Number of References: 15 ref. N2 - Serum samples from 96 Spanish haemodialysis patients [date not given], as well as serial dilutions of RNA extracted from a reference strain of hepatitis G virus (HGV), were tested for HGV or GB virus C (GBV-C) RNA. Two different reverse transcription (RT)-PCR-based methods of detection were compared for the ability to detect RNA extracted from the samples: an RT-nested PCR assay with primers derived from the 5′ noncoding region (5′NC) or nonstructural region 3 (NS3) sequences and a commercially available RT-PCR assay with primers derived from the 5′NC or NS5A sequences. When RT-nested PCR was performed on 10-fold serial dilutions of RNA from the HGV reference strain, the last positive dilution was 10-7-10-8. With the commercial RT-PCR assay, the last positive dilution was 10-6-10-7. When equal amounts of RNA extracted from serum samples from 96 haemodialysis patients were tested for HGV or GBV-C RNA, 25 patients (26%) were positive by the RT-nested PCR. However, only 21 (84%) of these 25 positive patients were positive for HGV or GBV-C by the commercial RT-PCR assay. Analysis of the 5′NC and NS3 sequences amplified by RT-nested PCR demonstrated that all but 2 positive patients had unique HGV or GBV-C sequences. It is concluded that RT-nested PCR and a commercially available RT-PCR assay for HGV or GBV-C gave concordant results for 96% of the patients tested. KW - blood KW - detection KW - diagnosis KW - hepatitis KW - hepatitis g KW - human diseases KW - polymerase chain reaction KW - viral diseases KW - Spain KW - hepatitis g virus KW - man KW - viruses KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - hepatitis GB virus c KW - PCR KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006672&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantitative urine cultures do not reliably detect renal candidiasis in rabbits. AU - Navarro, E. E. AU - Almario, J. S. AU - Schaufele, R. L. AU - Bacher, J. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1997/// VL - 35 IS - 12 SP - 3292 EP - 3297 SN - 0095-1137 AD - Navarro, E. E.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981200135. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Medical & Veterinary Mycology N2 - To determine the significance of quantitative urine cultures in renal candidosis, serial quantitative urinary cultures of Candida albicans in a rabbit model of haematogenous infection were studied. Of 197 urine samples from 34 infected animals, 144 were culture-positive, with a sensitivity of 73.1% for urine cultures and a lower limit of detection of 10 colony forming units (CFU)/ml. The yield of urine cultures varied according to severity and duration of infection. The mean renal and urinary concentrations of C. albicans from rabbits with subacute candidosis differed significantly from those from rabbits with acute candidosis (P=0.013 and P≤0.001, respectively). During the first 4 days of subacute renal candidosis, >50% of all urine cultures were negative for C. albicans. Only 12 (8.1%) of 148 urine cultures in animals with subacute renal candidosis had concentrations of >10³ CFU/ml, 2.7% had concentrations of >104 CFU/ml and none were ≥105 CFU/ml. In comparison, all urine cultures from the animals with lethal acute renal candidosis had higher concentrations of C. albicans and were positive throughout the course of infection. Urinary concentrations of C. albicans were not predictive of the amount of Candida in the kidney (r≤0.49) and did not correlate with survival (r=0.0232), although the renal concentration of C. albicans (in CFU/g) inversely correlated with the duration of survival (in days) of rabbits with renal candidosis (r=0.76; P<0.001). It is concluded that a negative urine culture in rabbits does not preclude the presence of renal candidosis. The interpretation of a urine culture positive at any concentration, however, must involve an analysis of the risk factors for renal candidosis, for any urinary concentration of C. albicans may reflect kidney infection. KW - candidosis KW - cultures KW - diagnosis KW - disease models KW - experimental infections KW - infections KW - isolation KW - kidneys KW - urine KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - candidiasis KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200135&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 acquires resistance to two classes of antiviral drugs through homologous recombination. AU - Yusa, K. AU - Kavlick, M. F. AU - Kosalaraksa, P. AU - Mitsuya, H. JO - Antiviral Research JF - Antiviral Research Y1 - 1997/// VL - 36 IS - 3 SP - 179 EP - 189 SN - 0166-3542 AD - Yusa, K.: The Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bld. 10, Room 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982002477. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9068-38-6, 30516-87-1. N2 - This study demonstrates that HIV-1 readily develops resistance to 2 classes of anti-HIV-1 drugs through in vitro genetic recombination involving large segments of the viral genome. Co-transfection of COS-7 cells with an HIV-1 plasmid (pSUM13) carrying 5 mutations in the reverse transcriptase (RT)-encoding region (A62V, V75I, F77L, F116Y, Q151M), conferring resistance to multiple dideoxynucleoside analogues (ddNs), and another HIV-1 plasmid (pSUM431) carrying five mutations in the protease-encoding region (V32I, L33F, K45I, I84V, L89M), conferring resistance to protease inhibitors such as KNI-272, readily produced HIV-1 carrying both sets of mutations when propagated in MT-2 cells in the presence of azidothymidine (AZT) and KNI-272. The resultant HIV-1 variant was highly resistant to both ddNs and KNI-272. Co-infection of MT-2 cells with HIV-1SUM13 carrying the RT mutations and HIV-1SUM431 carrying the mutations in the protease also generated HIV-1 with both sets of mutations when cultured with AZT and KNI-272. KW - analogues KW - antiviral agents KW - drug resistance KW - drugs KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - inhibitors KW - mutations KW - nucleoside analogues KW - nucleosides KW - polymerase chain reaction KW - proteinase inhibitors KW - proteinases KW - reverse transcriptase KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - AZT KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - medicines KW - nucleoside analogs KW - PCR KW - pharmaceuticals KW - protease inhibitors KW - proteases KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002477&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay. AU - Ueno, T. AU - Mitsuya, H. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1997/// VL - 36 IS - 5 SP - 1092 EP - 1099 SN - 0006-2960 AD - Ueno, T.: Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003049. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 7841-89-2, 9007-49-2, 9068-38-6, 63231-63-0. N2 - Employing the single-nucleotide incorporation assay using a heteropolymeric RNA template and DNA primers, enzymatic profiles were defined of recombinant HIV-1 reverse transcriptase (RT) containing a set of 5 mutations [A62V, V75I, F77L, F116Y, and Q151M] which confers resistance to multiple 2′,3′-dideoxynucleosides (ddNs) on HIV-1. RTs containing other drug-resistance-associated mutations were also examined. The Km for dNTPs, the kcat, and the kcal/Km ratios of mutant RTs were all comparable to those of wild-type RT (RTwt). The processive primer extension activity of mutant RTs was also comparable to that of RTwt as examined in the presence of saturating concentrations of dNTPs and heparin. Determination of the Ki values toward 5′-triphosphates (TP) of various ddNs [3′-azido-2′,3′-dideoxythymidine (AZT), 2′,3′-didehydro-2′-3′-dideoxythymidine (D4T), 2′,3′-dideoxycytidine (ddC), (-)-β-L-2′,3′-dideoxy-3′-thiacytidine (3TC), (-)-β-L-2′,3′-dideoxy-5-fluorocytidine (FddC), 2′,3′-dideoxyadenosine (ddA), and 2′-β-fluoro-2′,3′-dideoxyadenosine (FddA)] and 9-(2-phosphonylmethoxyethyl)adenine diphosphate (PMEApp) revealed that RTA62V/V75I/F77L/F116Y/Q151M was insensitive to ddATP, AZTTP, D4TTP, FddATP and ddCTP, but was sensitive to PMEApp, 3TCTP and FddCTP. RTK65R was less sensitive to ddATP, FddATP, PMEApp, ddCTP and 3TCTP, while RTM184V was less sensitive only to 3TCTP and ddCTP. The determination of Ki(ddNTP)/Km(dNTP) ratios showed that AZTTP, D4TTP and ddCTP are, as substrates, as efficient for RTwt as their corresponding dNTPs, that ddATP, PMEApp and 3TCTP are moderately efficient substrates for RTwt, and that FddATP is the least efficient substrate among ddNTPs examined. The observed cross-resistance of HIV-1 RT to various ddNTPs should reflect the alteration of RT's substrate recognition and should provide insights into the molecular mechanism of RT discrimination of ddNTPs from natural substrates. KW - antiviral agents KW - biochemistry KW - dideoxycytidine KW - DNA KW - enzyme inhibitors KW - molecular biology KW - molecular genetics KW - mutations KW - nucleotides KW - reverse transcriptase KW - reverse transcriptase inhibitors KW - RNA KW - treatment KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - biochemical genetics KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003049&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resistance pattern of 2816 isolates from 17 631 blood cultures and etiology of bacteremia and fungemia in a single cancer institution. AU - Trupl, J. AU - Kunová, A. AU - Oravcová, E. AU - Pichna, P. AU - Kukučková, E. AU - Grausova, S. AU - Grey, E. AU - Spanik, S. AU - Demitrovičová, A. AU - Kral'ovičová, K. AU - Lacka, J. AU - Krupova, I. AU - Svec, J. AU - Koren, P. AU - Krčméry, V., Jr. JO - Acta Oncologica JF - Acta Oncologica Y1 - 1997/// VL - 36 IS - 6 SP - 643 EP - 649 SN - 0001-6381 AD - Trupl, J.: Department of Microbiology, National Cancer Institute, Bratislava, Slovakia. N1 - Accession Number: 19981201485. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 86386-73-4, 82419-36-1. Subject Subsets: Medical & Veterinary Mycology N2 - The resistance pattern of 2816 isolates from 17 631 blood cultures and the aetiology of isolates causing bacteraemia and fungaemia among 14 591 admissions were investigated in an 80-bed single cancer institute in Bratislava, Slovakia, during 1990-96, under the same empiric therapeutic antibiotic policy but with different prophylactic strategies. No change was found in the proportion of Gram positive vs. Gram negative bacterial isolates from bacteraemia (70% vs. 30%) during the 7-year period. The proportion of coagulase-negative staphylococci and enterococci was approx. the same before and after the introduction of ofloxacin in prophylaxis. The proportion of Pseudomonas aeruginosa and Stenotrophomonas maltophilia causing bacteraemia increased. There was no increase in Candida krusei and C. glabrata [Torulopsis glabrata] after the introduction of fluconazole into prophylactic regimens in 1992. Penicillin-resistance in viridans streptococci increased after penicillin was introduced into prophylaxis in acute leukaemia in 1993. Until 1995 no quinolone-resistant Enterobacteriaceae were observed. Susceptibility to quinolones did not significantly change within the past seven years in Enterobacteriaceae after their introduction to prophylaxis in 1991, but Pseudomonas aeruginosa decreased from 90% to 58.2%. Glycopeptide resistance in enterococci and staphylococci was minimal in the observed period (0.9-4.3%). KW - bacteraemia KW - bacterial diseases KW - blood KW - candidosis KW - drug resistance KW - fluconazole KW - fungaemia KW - human diseases KW - immunocompromised hosts KW - infections KW - neoplasms KW - ofloxacin KW - opportunistic infections KW - penicillins KW - predisposition KW - quinolones KW - Slovakia KW - Candida acidothermophilum KW - Candida glabrata KW - Enterobacteriaceae KW - man KW - Pseudomonas aeruginosa KW - Staphylococcus KW - Stenotrophomonas maltophilia KW - Streptococcus KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudomonas KW - Pseudomonadaceae KW - Pseudomonadales KW - Staphylococcaceae KW - Bacillales KW - Bacilli KW - Firmicutes KW - Stenotrophomonas KW - Xanthomonadaceae KW - Xanthomonadales KW - Streptococcaceae KW - Lactobacillales KW - Torulopsis KW - Pezizomycotina KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - bacteremia KW - bacterial infections KW - bacterioses KW - bacterium KW - cancers KW - Candida krusei KW - candidiasis KW - fungemia KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201485&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1IIIB GP120 peptide RP135. AU - Huang XiaoLin AU - Barchi, J. J., Jr. AU - Lung, F. D. T. AU - Roller, P. P. AU - Nara, P. L. AU - Muschik, J. AU - Garrity, R. R. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1997/// VL - 36 IS - 36 SP - 10846 EP - 10856 SN - 0006-2960 AD - Huang XiaoLin: Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972009859. Publication Type: Journal Article. Language: English. Number of References: 72 ref. N2 - Simple O-glycosylation was shown to have significant effects on the conformation of an important peptide epitope from the V3 loop by stabilizing a reverse turn and rigidifying the backbone conformations proximal to the glycosylation sites. These structural adjustments resulted in an enhanced binding to a monoclonal antibody which was raised to HIV-IIIB-infected cells and mapped to the unglycosylated epitope sequence. Studies such as this may be valuable in determining whether the presence of carbohydrates affects the three-dimensional conformation of gp120 subdomains. Additionally, covalently linked glycans may enhance epitope-specific antibody binding of these subdomains and prove useful in the design of glycopeptide-based vaccines. KW - antibodies KW - binding KW - biochemistry KW - conformation KW - env gene KW - envelope protein gp120 KW - epitopes KW - HIV-1 infections KW - human diseases KW - microbiology KW - properties KW - structural genes KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenic determinants KW - body conformation KW - glycosylation KW - gp120 KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009859&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts. AU - Hui, R. AU - Everhart, A. L. AU - Glasgow, W. C. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1997/// VL - 38 IS - 1 SP - 49 EP - 60 SN - 0022-2275 AD - Hui, R.: Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19971403024. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 60-33-3, 9026-43-1. Subject Subsets: Human Nutrition N2 - The uptake and mobilization of 13(S)-hydroxyoctadecadienoic acid (HODE) was investigated in Syrian hamster embryo (SHE) cells with a normal phenotype (supB+ cells) and that have lost tumour suppression function (supB- cells). Epidermal growth factor (EGF) 10 ng/ml stimulated a time- and dose-dependent incorporation and reacylation of 10\microM 13-HODE. The level of 13-HODE uptake in supB+ SHE cells was twice that of supB- SHE cells. Among classes of phospholipids, radiolabelled 10 µM 13-HODE was esterified predominantly into phosphatidylcholine and this distribution pattern was similar for both SHE cell lines. Pretreatment of cells with 10 µM of the tyrosine kinase inhibitor methyl-2,5-dihydroxycinnamate blocked EGF-stimulated HODE incorporation. Inhibition of tyrosine phosphatase activity with 100 µM sodium orthovanadate potentiated HODE uptake in supB+ but not supB- cells. Moreover, activation of protein kinase C with 20 nM phorbol ester stimulated HODE incorporation in the supB+ line only. It is concluded that the differential effects of EGF on 13-HODE uptake and mobilization in supB+ and supB- cells appear to be related to loss of the tumour suppressor phenotype. EGF-stimulated generation of esterified 13-HODE may be an important biological process in determining the mechanism and site of HODE interaction with the mitogenic signalling pathway. KW - cell cultures KW - enzymes KW - epidermal growth factor KW - fibroblasts KW - genetics KW - inhibitors KW - linoleic acid KW - metabolism KW - metabolites KW - mitogens KW - mobilization KW - neoplasms KW - phenotypes KW - phosphatidylcholines KW - phospholipids KW - protein kinase KW - uptake KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - lecithins KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403024&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat. AU - Purdon, D. AU - Arai, T. AU - Rapoport, S. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1997/// VL - 38 IS - 3 SP - 526 EP - 530 SN - 0022-2275 AD - Purdon, D.: Laboratory of Neurosciences, National Institute of Aging, National Institutes of Health, Bldg. 10, Room 6C-103, Bethesda, MD 20892, USA. N1 - Accession Number: 19971405111. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 57-88-5, 57-10-3. Subject Subsets: Human Nutrition N2 - Awake adult rats were given a solution of [9,10-³H]palmitate ([³H]PAM) by gavage. The appearance of radiolabel in plasma lipid fractions was monitored by thin-layer chromatography at fixed intervals thereafter. At 2 h, the rats were killed by microwave irradiation and radioactivity in whole brain and individual brain phospholipids was determined. In plasma, esterified [³H]PAM was mainly associated with triglyceride, phospholipid and cholesterol ester. Radioactivity appeared to a larger extent in triglyceride than in unesterified fatty acid, suggesting that unesterified [³H]PAM in plasma was largely due to release from esterified [³H]PAM by lipoprotein lipase hydrolysis. Brain radioactivity could be accounted for entirely by incorporation of unesterified plasma [³H]PAM. Esterified [³H]PAM in chylomicrons or lipoproteins was calculated to make no measurable contribution using a published value for the incorporation coefficient of [³H]PAM into brain in the evaluation. The results suggest that ingested palmitic acid (PAM) in adult rats enters blood as esterified triglyceride within chylomicrons and lipoproteins and, in part, eventually is converted to circulating unesterified PAM. It is the circulating unesterified PAM that is incorporated into brain from blood, whereas esterified PAM within plasma chylomicrons and lipoproteins makes no measurable direct contribution. KW - blood lipids KW - brain KW - cholesterol KW - chylomicron lipids KW - esterification KW - esters KW - fatty acids KW - incorporation KW - lipids KW - lipoproteins KW - palmitic acid KW - phospholipids KW - plasma KW - triacylglycerols KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - chylomicrons KW - hexadecanoic acid KW - lipins KW - triglycerides KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405111&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A new route to N-substituted 11-azaartemisinins. AU - Mekonnen, B. AU - Ziffer, H. JO - Tetrahedron Letters JF - Tetrahedron Letters Y1 - 1997/// VL - 38 IS - 5 SP - 731 EP - 734 SN - 0040-4039 AD - Mekonnen, B.: NIMH, Laboratory of Clinical Science, National Institutes of Health, Bethesda, MD 20892-0510, USA. N1 - Accession Number: 19980807472. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 63968-64-9. Subject Subsets: Botanical Pesticides; Protozoology N2 - A series of N-substituted 11-azaartemisinins were prepared in high yield by Michael additions to the amide nitrogen of 11-azaartemisinin. The presence of substituents on the unsaturated system of the Michael acceptor markedly decreased the yield of the reaction. KW - antimalarials KW - antiprotozoal agents KW - artemisinin KW - chemistry KW - human diseases KW - malaria KW - parasites KW - sesquiterpenoid lactones KW - synthesis KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - artemisinine KW - azaartemisinins KW - qinghaosu KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807472&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overexpression of human lecithin:cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner. AU - Brousseau, M. E. AU - Santamarina-Fojo, S. AU - Vaisman, B. L. AU - Applebaum-Bowden, D. AU - Bérard, A. M. AU - Talley, G. D. AU - Brewer, H. B., Jr. AU - Hoeg, J. M. JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1997/// VL - 38 IS - 12 SP - 2537 EP - 2547 SN - 0022-2275 AD - Brousseau, M. E.: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981404321. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 57-88-5, 9031-14-5. Subject Subsets: Human Nutrition N2 - 131I-labelled HDL apolipoprotein (apo)A-I and 125I-labelled LDL kinetics were assessed in age- and sex-matched groups of rabbits with high (HE), low (LE) or no human lecithin:cholesterol acyltransferase [phosphatidylcholine-sterol acyltransferase] (LCAT) expression after 6 weeks on a 0.3% cholesterol diet. In HE, the mean total cholesterol concentration (mg/100 ml) on this diet (230±50) was not significantly different from that of LE (313±46) or controls (332±52) due to the increased level of HDL-cholesterol (C) observed in HE (127±19), as compared with LE (100±33) and controls (31±4). In contrast, the mean nonHDL-C concentration for HE (103±33) was much lower than that for LE (213±39) or controls (301±55). Fast protein liquid chromatography analysis of plasma confirmed that HDL was the predominant lipoprotein class in HE on the cholesterol diet, whereas cholesteryl ester-rich, apoB-containing lipoproteins characterized the plasma of LE and, most notably, of controls. In vivo kinetic experiments demonstrated that the differences in HDL levels noted between the 3 groups were attributable to distinctive rates of apoA-I catabolism, with the mean fractional catabolic rate (FCR)/day of apoA-I slowest in HE (0.282±0.03), followed by LE (0.340±0.01) and controls (0.496±0.04). A similar, but opposite, pattern was observed for nonHDL-C levels and LDL metabolism (h-1), such that HE had the lowest nonHDL-C levels with the fastest rate of clearance (0.131±0.027), followed by LE (0.057±0.009) and controls (0.031±0.001). Strong correlations were noted between LCAT activity and apoA-I (r = -0.868, P<0.01) and LDL (r = 0.670) FCR, indicating that LCAT activity played a major role in the mediation of lipoprotein metabolism. It is concluded that these data are the first to show that LCAT overexpression can regulate both LDL and HDL metabolism in cholesterol-fed rabbits and provide a potential explanation for the prevention of diet-induced atherosclerosis previously observed. KW - apolipoproteins KW - atherosclerosis KW - blood KW - cholesterol KW - gene expression KW - high density lipoprotein KW - intake KW - kinetics KW - lipoproteins KW - low density lipoprotein KW - metabolism KW - phosphatidylcholine-sterol acyltransferase KW - rabbits KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arteriosclerosis KW - lecithin-cholesterol acyltransferase KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404321&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spinal intramedullary cysticercosis. AU - Mohanty, A. AU - Venkatrama, S. K. AU - Das, S. AU - Shankar, B. AU - Rao, B. R. AU - Vasudev, M. K. JO - Neurosurgery JF - Neurosurgery Y1 - 1997/// VL - 40 IS - 1 SP - 82 EP - 87 SN - 0148-396X AD - Mohanty, A.: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India. N1 - Accession Number: 19970803222. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Helminthology N2 - Eight patients who were surgically treated for spinal intramedullary cysticercosis between 1982 and 1991 in Bangalore, Karnataka, India, were retrospectively reviewed, and the final outcomes were assessed. In 6 patients, the cysticercosis involved the thoracic cord, whereas in the other 2, the cysticercosis was cervical in location. Only one patient had multiple soft tissue calcifications, as revealed by plain radiography. Myelography indicated an intramedullary lesion in each of 7 patients; 2 of the 7 patients had partial myelographic block, suggesting the segmental nature of the lesion. Cerebrospinal fluid studies were non-contributory. One patient had 3 cysts, whereas the other 7 had 1 cyst each. Four patients had adjacent soft purulent materials, which were revealed by histopathological examination to be granulation tissue. The neurological statuses of 7 patients improved after surgery. Six patients were followed up for a mean of 30.6 months (3 months to 5 years). Three resumed their previous occupations, 2 others were able to manage their daily activities, and one required only minimal assistance for daily activities. KW - case reports KW - cysticercosis KW - helminths KW - human diseases KW - metacestodes KW - parasites KW - spinal cord KW - India KW - Karnataka KW - man KW - Taenia solium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - Mysore KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803222&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 integrase pharmacophore: discovery of inhibitors through three dimensional database searching. AU - Nicklaus, M. C. AU - Neamati, N. AU - Hong HuiXiao AU - Mazumder, A. AU - Sunder, S. AU - Chen, J. AU - Milne, G. W. A. AU - Pommier, Y. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 6 SP - 920 EP - 929 SN - 0022-2623 AD - Nicklaus, M. C.: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972003704. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - Starting from a known inhibitor of HIV-1 integrase (IN), caffeic acid phenethyl ester (CAPE), putative three-point pharmacophore for binding of inhibitors to IN was derived. This pharmacophore was used to search the National Cancer Institute three-dimensional (3D) structural database. Out of the open, nonproprietary part of this database, comprising approximately 200,000 compounds, 267 structures were found to match the pharmacophore in at least one conformation, and 60 of these were tested in an in vitro assay against HIV-1 IN. Out of these, 19 were found to inhibit both the 3' processing and strand transfer of IN at micromolar concentrations. In order to test the validity of this pharmacophore, a small 3D database of 152 published IN inhibitors was built. A search in this database yielded a statistically significant correlation of the presence of this pharmacophore and the potency of the compounds. An automated pharmacophore identification procedure performed on this set of compounds provided additional support for the importance of this pharmacophore for binding of inhibitors to IN and hinted at a possible second pharmacophore. The role of aromatic moieties in the binding of ligands to HIV-1 IN through interactions with divalent metal cations, which are known to be necessary for activity of the enzyme, was explored in ab initio calculations. KW - antiviral agents KW - antiviral properties KW - aromatic compounds KW - assays KW - databases KW - in vitro KW - inhibitors KW - interactions KW - treatment KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - aromatics KW - data banks KW - human immunodeficiency virus type 1 KW - integrase inhibitors KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003704&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Discovery of HIV-1 integrase inhibitors by pharmacophore searching. AU - Hong HuiXiao AU - Neamati, N. AU - Wang ShaoMeng AU - Nicklaus, M. C. AU - Mazumder, A. AU - Zhao, H. AU - Burke, T. R., Jr. AU - Pommier, Y. AU - Milne, G. W. A. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 6 SP - 930 EP - 936 SN - 0022-2623 AD - Hong HuiXiao: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972003705. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - Based upon a class of known HIV-1 integrase inhibitors, several pharmacophore models were proposed from molecular modelling studies and validated using a 3D database of 152 compounds for which integrase assay data are known. Using the most probable pharmacophore model as the query, the NC1 3D database of 206,876 compounds was searched, and 340 compounds that contain the pharmacophore query were identified. 29 of these compounds were selected and tested in the HIV-1 integrase assay. This led to the discovery of 10 novel, structurally diverse HIV-1 integrase inhibitors, four of which have an IC50 value <30 µM and are promising lead compounds for further HIV-1 integrase inhibitor development. KW - antiviral agents KW - antiviral properties KW - databases KW - inhibitors KW - models KW - treatment KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - data banks KW - human immunodeficiency virus type 1 KW - integrase inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003705&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hydrazide-containing inhibitors of HIV-1 integrase. AU - Zhao He AU - Neamati, N. AU - Sunder, S. AU - Hong HuiXiao AU - Wang ShaoMeng AU - Milne, G. W. A. AU - Pommier, Y. AU - Burke, T. R., Jr. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 6 SP - 937 EP - 941 SN - 0022-2623 AD - Zhao He: Laboratories of Medicinal Chemistry and Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972003706. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 120-80-9. N2 - A large number of inhibitors of HIV integrase discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely on this potentially cytotoxic catechol substructure, NSC 310217 was identified using a three-point pharmacophore search based on its assigned structure N-(2-hydroxybenzoyl)-N-(2-hydroxy-3-phenoxypropyl)hydrazine. When a sample of NSC 310217 was obtained from the NCI repository, it was shown to exhibit potent inhibition of HIV-1 integrase (3′-processing IC50=0.6 µg/ml). Work reported herein demonstrates that NSC 320217, rather than containing N-(2-hydroxybenzoyl)-N-(2-hydroxy-3-phenoxypropyl)hydrazine, which has no inhibitory potency against HIV-1 integrase, is comprised of roughly a 1:1 mixture of N-(2-hydroxybenzoyl)-N′-(2-hydroxy-3-phenoxypropyl)hydrazine and N,N′-bis-salicylhydrazine, with all inhibitory potency residing with the latter compound (IC50 = 0.7 µM for strand transfer). KW - antiviral agents KW - antiviral properties KW - cytotoxicity KW - human immunodeficiency viruses KW - inhibition KW - inhibitors KW - pyrocatechol KW - structure KW - treatment KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - anti-viral properties KW - catechol KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - integrase inhibitors KW - pyrocatechin KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003706&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. AU - Neamati, N. AU - Hong HuiXiao AU - Mazumder, A. AU - Wang ShaoMeng AU - Sunder, S. AU - Nicklaus, M. C. AU - Milne, G. W. A. AU - Proksa, B. AU - Pommier, Y. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 6 SP - 942 EP - 951 SN - 0022-2623 AD - Neamati, N.: Laboratories of Molecular Pharmacology and Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972003707. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - 17 lichen acids comprising depsides, depsidones and their synthetic derivatives were examined for their inhibitory activity against HIV-1 integrase, and 2 pharmacophores associated with inhibition of this enzyme were identified. A search of the NCI 3D database of approx. 200,000 structures yielded some 800 compounds which contain one or the other pharmacophore. 42 of these compounds were assayed for HIV-1 integrase inhibition, and of these 27 had inhibitory IC50 values of <100 µM; 15 were below 50 µM. Several of these compounds were also examined for their activity against HIV-1 integrase and mammalian topoisomerase. KW - antiviral agents KW - antiviral properties KW - databases KW - derivatives KW - inhibition KW - inhibitors KW - treatment KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - data banks KW - human immunodeficiency virus type 1 KW - integrase inhibitors KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003707&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Arylamide inhibitors of HIV-1 integrase. AU - Zhao, H. AU - Neamati, N. AU - Mazumder, A. AU - Sunder, S. AU - Pommier, Y. AU - Burke, T. R., Jr. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 8 SP - 1186 EP - 1194 SN - 0022-2623 AD - Zhao, H.: Laboratory of Medicinal Chemistry, Bldg 37, Rm 5C06, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004644. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9007-49-2. KW - antiviral agents KW - DNA KW - enzymes KW - HIV-1 infections KW - human diseases KW - inhibitors KW - integration KW - microbiology KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - arylamides KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004644&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. AU - Mazumder, A. AU - Neamati, N. AU - Sunder, S. AU - Pertz, H. AU - Eich, E. AU - Pommier, Y. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 19 SP - 3057 EP - 3063 SN - 0022-2623 AD - Mazumder, A.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bldg 37, Rm 5C25, Bethesda, MD 20892, USA. N1 - Accession Number: 19972009823. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 458-37-7, 9007-49-2. N2 - The present study explores the mechanism of action of curcumin (diferuloylmethane) in detail using natural and synthetic analogues. Equivalent potencies of curcumin analogues are demonstrated against wild-type integrase and an integrase protein containing a mutation in the DNA binding domain. The synergistic effects obtained using a curcumin analogue in combination with another integrase inhibitor, NSC 158393, are reflective of drug binding sites which may not overlap. Binding of these analogues to the enzyme and these enzyme-inhibitor complexes to viral DNA was examined. These studies can provide mechanistic and structural information which may guide the future design of integrase inhibitors. Editorial comment:Integrase is one of the three critical enzymes in the HIV replication cycle (reverse transcriptase and protease are the other two) that can be targeted for therapeutic interventions. It has remained the most elusive of them. Studies like this one help us understand better how this enzyme works and show inhibition by curcumin (a natural colourant of some tropical medicinal plants). This knowledge should help in the design of new integrase inhibitor drugs that could be potentially useful in the future. KW - antiviral agents KW - antiviral properties KW - binding KW - curcumin KW - DNA KW - drugs KW - enzymes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - information KW - inhibition KW - mutations KW - proteinases KW - replication KW - structure KW - treatment KW - Curcuma aromatica KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Curcuma KW - Zingiberaceae KW - Zingiberales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - human immunodeficiency viruses KW - anti-viral properties KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - integrase KW - integrase inhibitors KW - medicines KW - pharmaceuticals KW - proteases KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009823&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-aryl-substituted benzimidazoles. AU - Roth, T. AU - Morningstar, M. L. AU - Boyer, P. L. AU - Hughes, S. H. AU - Buckheit, R. W. Jr. AU - Michejda, C. J. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1997/// VL - 40 IS - 26 SP - 4199 EP - 4207 SN - 0022-2623 AD - Roth, T.: Molecular Aspects of Drug Design Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA. N1 - Accession Number: 19982001945. Publication Type: Journal Article. Language: English. Number of References: 25 ref. N2 - The best inhibitor, 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole has an IC50 = 200 nM against HIV-1 wild-type reverse transcriptase in an in vitro enzyme assay. Cytoprotection assays utilizing HIV-infected MT-4 cells revealed that it had strong antiviral activity (EC50 = 440) against wild-type virus while retaining broad activity against many clinically observed HIV-1 strains resistant to nonnucleoside inhibitors. KW - antiviral agents KW - enzyme inhibitors KW - human diseases KW - human immunodeficiency viruses KW - imidazoles KW - in vitro KW - inhibitors KW - resistance KW - reverse transcriptase inhibitors KW - strains KW - synthesis KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - non-nucleoside reverse transcriptase inhibitors KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001945&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fungaemia caused by Hansenula anomala - an outbreak in a cancer hospital. AU - Thuler, L. C. S. AU - Faivichenco, S. AU - Velasco, E. AU - Martins, C. A. AU - Nascimento, C. R. G. AU - Castilho, I. A. M. A. JO - Mycoses JF - Mycoses Y1 - 1997/// VL - 40 IS - 5-6 SP - 193 EP - 196 SN - 0933-7407 AD - Thuler, L. C. S.: Cancer Hospital, National Cancer Institute, CEP 20230-130, Rio de Janeiro, Brazil. N1 - Accession Number: 19981200468. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology; Tropical Diseases N2 - An outbreak of 24 cases of fungaemia due to H. anomala is reported from a cancer hospital in Rio de Janeiro, Brazil, during July 1994-April 1996. The median age of the patients was 11 years, of whom 54.2% were female; 91.7% of the Hansenula fungaemia cases occurred in the haematology unit. The most frequent primary disease diagnosis was leukaemia (62.5%) and all of those infected had had a central venous catheter or peripheral venous catheter and had been treated previously with broad-spectrum antibiotics. Numerous other risk factors were observed: previous use of steroids, chemotherapy, radiation therapy and neutropenia. No deaths could be attributed to Hansenula infection. KW - blood KW - fungaemia KW - human diseases KW - immunocompromised hosts KW - infections KW - leukaemia KW - neoplasms KW - nosocomial infections KW - opportunistic infections KW - predisposition KW - Brazil KW - man KW - Pichia anomala KW - Saccharomycetaceae KW - Hansenula KW - Pichiaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Pichia KW - blood cancer KW - cancers KW - fungemia KW - fungus KW - Hansenula anomala KW - hospital infections KW - leucaemia KW - leukemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200468&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors. AU - Neamati, N. AU - Mazumder, A. AU - Zhao, H. AU - Sunder, S. AU - Burke, T. R., Jr. AU - Schultz, R. J. AU - Pommier, Y. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1997/// VL - 41 IS - 2 SP - 385 EP - 393 SN - 0066-4804 AD - Neamati, N.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972002421. Publication Type: Journal Article. Language: English. Number of References: 30 ref. N2 - The inhibitory effect of a series of sulfones and sulfonamides against HIV integrase (IN) was determined. Among 52 diaryl sulfones tested, 4 were highly potent (50% inhibitory concentration (IC50), 0.8-10 µg/ml), 5 had good potencies (IC50, 11-50 µg/ml), 10 showed moderate potencies (IC50, 51-100 µg/ml) and 33 were inactive (IC50 >100 µg/ml) against IN. All of the active compounds exhibited similar potencies against HIV-2 IN. Sulfa drugs, used extensively in treating Pneumocystis carinii pneumonia, were also examined. Among 19 sulfonamides tested, sulfasalazine (IC50 50 µg/ml) was the most potent. It is concluded that potent inhibitors of IN can be designed based on the results presented in this study. KW - acquired immune deficiency syndrome KW - antiviral agents KW - antiviral properties KW - human immunodeficiency viruses KW - inhibition KW - inhibitors KW - mortality KW - sulfonamides KW - treatment KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - AIDS KW - anti-viral properties KW - death rate KW - diarylsulfones KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - integrase inhibitors KW - sulphonamides KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002421&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology. AU - Humphrey, R. W. AU - Ohagen, A. AU - Davis, D. A. AU - Fukuzawa, T. AU - Hayashi, H. AU - Höglund, S. AU - Mitsuya, H. AU - Yarchoan, R. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1997/// VL - 41 IS - 5 SP - 1017 EP - 1023 SN - 0066-4804 AD - Humphrey, R. W.: Correspondence address [Yarchoan, R.]: HIV and AIDS Malignancy Branch of the National Cancer Institute, Bldg 10, Rm. 12N226, National Institutes of Health, Bethesda, MD 20892-1906, USA. N1 - Accession Number: 19972005244. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0. N2 - The processing of gag and gag-pol polyproteins by HIV-1 protease is a crucial step in the formation of infectious HIV-1 virions. This study examined whether particles produced in the presence of inhibitors of HIV-1 protease can subsequently undergo gag polyprotein cleavage with restoration of infectivity following removal of the inhibitors. Viral particles produced during 7 days of culture in the presence of the protease inhibitors KNI-272 (10 µM) and saquinavir (5µM) contained predominantly p55gag polyprotein but little or no p24gag cleavage product. Following resuspension of the particles in medium free of the inhibitor, some gag polyprotein processing was detected in particles produced from the KNI-272-treated cells, but not from the saquinavir-treated cells within the first 3 h. However, the majority of the protein remained as p55gag throughout a 48-h experimental period. The infectivity (50% tissue culture infective dose per ml) of the viral particles from KNI-272-treated cells was 106-fold lower than that of control particles and did not significantly increase over the 48 h after the inhibitor-treated cells nor to a failure of HIV RNA to be packaged in the virions. These particles also failed to express the mature phenotype by electron microscopy. Thus, while some processing of the gag polyprotein can occur in isolated HIV virions, this does not appear to be sufficient to restore infectivity in the majority of particles. This finding suggests that there may be constraints on postbudding polyprotein processing in the production of viable particles. These results should have positive implications regarding the use of protease inhibitors as anti-HIV drugs. KW - antiviral agents KW - experiments KW - formulations KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - infectivity KW - inhibitors KW - phenotypes KW - proteinase inhibitors KW - proteinases KW - RNA KW - treatment KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - protease inhibitors KW - proteases KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005244&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vitro induction of human immunodeficiency virus type 1 variants resistant to 2′-β-fluoro-2′,3′-dideoxyadenosine. AU - Tanaka, M. AU - Srinivas, R. V. AU - Ueno, T. AU - Kavlick, M. F. AU - Hui, F. K. AU - Fridland, A. AU - Driscoll, J. S. AU - Mitsuya, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1997/// VL - 41 IS - 6 SP - 1313 EP - 1318 SN - 0066-4804 AD - Tanaka, M.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006176. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9068-38-6. N2 - 2′-β-Fluoro-2′,3′-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analogue active against a wide spectrum of HIV-1 and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. HIV-1 variants resistant to F-ddA were induced by exposing wild-type HIV-1 (HIV-1LAI) to increasing concentrations of F-ddA in vitro. After 18 passages, the virus was 4-fold less sensitive to F-ddA than HIV-1LAI. Sequence analyses of the passage 18 virus revealed changes in 3 amino acids in the reverse transcriptase (RT)-encoding region of the pol gene: P to S at codon 119 (P119S; present in 3 of 13 and 28 of 28 molecular clones before and after F-ddA exposure, respectively). V179D (0 of 13 and 9 of 28, respectively), and L214F (9 of 13 and 28 of 28, respectively). Drug sensitivity assays using recombinant infectious clones confirmed that P119S was directly responsible for the reduced sensitivity of HIV-1 to F-ddA. Various infectious clones with single or multiple amino acid substitutions conferring viral resistance against nucleoside RT inhibitors, including HIV-1 variants with multi-dideoxynucleoside resistance, were generally sensitive to F-ddA. The moderate level of resistance of HIV-1 to F-ddA, together with the lack of conferment of significant cross-resistance by the F-ddA-associated amino acid substitutions, warrants further investigation of F-ddA as a potential antiviral agent for use in treatment of HIV-1 infection. KW - amino acids KW - analogues KW - antiviral agents KW - clinical aspects KW - clinical trials KW - clones KW - drug resistance KW - drugs KW - human immunodeficiency viruses KW - in vitro KW - nucleoside analogues KW - nucleosides KW - resistance KW - reverse transcriptase KW - strains KW - susceptibility KW - treatment KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - analogs KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - medicines KW - molecular clones KW - nucleoside analogs KW - pharmaceuticals KW - sensitivity KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006176&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection. AU - Polis, M. A. AU - Piscitelli, S. C. AU - Vogel, S. AU - Witebsky, F. G. AU - Conville, P. S. AU - Petty, B. AU - Kovacs, J. A. AU - Davey, R. T., Jr. AU - Walker, R. E. AU - Falloon, J. AU - Metcalf, J. A. AU - Craft, C. AU - Lane, H. C. AU - Masur, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1997/// VL - 41 IS - 8 SP - 1709 EP - 1714 SN - 0066-4804 AD - Polis, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, RM 11C103, Mailstop 1880, Bethesda, MD 20982-1880, USA. N1 - Accession Number: 19972008302. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 81103-11-9, 30516-87-1. N2 - Co-administration of zidovudine (AZT) and clarithromycin at 3 doses (500 mg orally [po] twice daily [bid], 1000 mg po bid, and 2000 mg po bid) reduced the maximum concentration of AZT by 41% (P<0.005) and the area under the concentration-time curve from 0 to 4 hours for AZT by 25% (P<0.05) and increased the time to maximum concentration of AZT by 84% (P< 0.05), compared with AZT administered alone. Mixing studies did not detect the formation of insoluble complexes due to chelation, suggesting that the decrease in AZT concentrations results from some other mechanism. Simultaneous administration of AZT and clarithromycin appears to decrease the levels of AZT in serum, and it may be advisable that these drugs not be given at the same time. Drug interactions should be carefully evaluated in persons with advanced HIV infection who are receiving multiple pharmacological agents. KW - acquired immune deficiency syndrome KW - antiviral agents KW - blood plasma KW - clarithromycin KW - concentration KW - drug therapy KW - drugs KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - pharmacokinetics KW - treatment KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - medicines KW - pharmaceuticals KW - plasma (blood) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008302&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intraspecific variation and phylogenetic relationships in the genus Entamoeba as revealed by riboprinting. AU - Clark, C. G. AU - Diamond, L. S. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1997/// VL - 44 IS - 2 SP - 142 EP - 154 SN - 1066-5234 AD - Clark, C. G.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19980801418. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Subject Subsets: Protozoology N2 - Eighty-seven isolates of amoebae assigned to the genus Entamoeba were studied by riboprinting (restriction enzyme polymorphism analysis of polymerase chain reaction-amplified small subunit ribosomal RNA genes). Twenty-four distinct patterns were obtained, most of which corresponded to previously described species. In 3 species (Entamoeba coli, E. gingivalis and E. moshkovskii) intraspecific variation was detected that led to the grouping of isolates into 'ribodemes' (populations of amoebae that shared the same riboprint pattern). Riboprint data were used to estimate genetic distances among and within species for the construction of phylogenetic trees based on parsimony and distance analyses. The trees obtained with the 2 methods were largely congruent. In some cases the estimated distances between species were greater than the upper limit recommended for the fragment comigration method of analysis, indicating unusually deep branches within this genus. However, it appeared that species producing cysts with 8 nuclei, species producing cysts with 1 nucleus and species producing cysts with 4 nuclei form morphologically based groups that are supported by riboprint data. E. gingivalis, which does not encyst, clusters with the third group, indicating secondary loss of this ability. KW - amoebae KW - genes KW - genetic mapping KW - genetic polymorphism KW - molecular taxonomy KW - morphology KW - parasites KW - phylogeny KW - polymerase chain reaction KW - restriction endonuclease analysis KW - ribosomal RNA KW - strains KW - Entamoeba KW - Entamoeba coli KW - Entamoeba gingivalis KW - Entamoeba moshkovskii KW - protozoa KW - Endamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Entamoeba KW - cysts KW - PCR KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801418&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Influence of diet on mammary cancer in transgenic mice bearing an oncogene expressed in mammary tissue. AU - Rao, G. N. AU - Ney, E. AU - Herbert, R. A. JO - Breast Cancer Research and Treatment JF - Breast Cancer Research and Treatment Y1 - 1997/// VL - 45 IS - 2 SP - 149 EP - 158 SN - 0167-6806 AD - Rao, G. N.: Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19981406970. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition N2 - The transgenic mouse line TG.NK with c-neu, the human breast cancer oncogene homologue of erbB2, was evaluated to determine its suitability for study of intervention strategies to delay/prevent the development of breast cancer. There were no palpable mammary tumour masses up to 22-weeks of age, and almost all mice fed on a purified diet developed palpable mammary tumours by 28-weeks of age. Nonpurified diets decreased the incidence and multiplicity, and delayed the development of mammary tumours as compared to a purified diet. Increasing the fibre content of nonpurified diet decreased the tumour incidence further. There was approximately a 19-week interval between weaning and development of palpable mammary masses to evaluate intervention strategies to delay or prevent the development of mammary cancer in the TG.NK mouse model. Fibre from nonpurified cereal ingredients appears to be highly beneficial in delaying the development of mammary cancer in TG.NK mice, and this observation is in agreement with human epidemiological findings. Therefore, the TG.NK transgenic mouse with oncogene c-neu (erbB2), appears to be a useful animal model for evaluation of dietary intervention strategies. KW - animal models KW - diet KW - fibre KW - intake KW - mammary gland neoplasms KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fiber KW - mammary tumour KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406970&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Meta-analyses of dietary fats and mammary neoplasms in rodent experiments. AU - Fay, M. P. AU - Freedman, L. S. A2 - Clarke, R. JO - Breast Cancer Research and Treatment JF - Breast Cancer Research and Treatment Y1 - 1997/// VL - 46 IS - 2/3 SP - 215 EP - 223 SN - 0167-6806 AD - Fay, M. P.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda MD, USA. N1 - Accession Number: 19981405785. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition N2 - Two meta-analyses of experiments on dietary fat and mammary tumour incidence in rodents are reviewed, emphasizing a meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 PUFA most strongly enhance mammary tumours in rodents and that saturated fats also enhance tumours, although less strongly. The research also shows that energy restriction protects against mammary tumours. It is demonstrated that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations. KW - animal models KW - energy deprivation KW - fats KW - fatty acids KW - intake KW - international comparisons KW - mammary gland neoplasms KW - polyenoic fatty acids KW - reviews KW - saturated fats KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - polyunsaturated fatty acids KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981405785&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients. AU - Ravi, V. AU - Parida, S. AU - Desai, A. AU - Chandramuki, A. AU - Gourie-Devi, M. AU - Grau, G. E. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1997/// VL - 51 IS - 2 SP - 132 EP - 136 SN - 0146-6615 AD - Ravi, V.: Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. N1 - Accession Number: 19970504233. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 308079-78-9. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases N2 - To investigate the prognostic role of tumour necrosis factor (TNF) in Japanese encephalitis (JE) virus infection, the authors measured the immunoreactive forms of TNF concentrations in the serum and cerebrospinal fluid (CSF) of 47 laboratory-confirmed cases of JE (in Bangalore, India). It was observed that TNF levels were elevated (>15 pg/ml) in all the 47 serum samples (range 19.4-923.8 pg/ml), while in 46 of 47 CSF samples TNF was elevated (range 10.8-376 pg/ml). The mean (SD) TNF levels in the serum of fatal cases was 234.34 pg/ml (304.40) as compared to the mean of 85.31 pg/ml (SD 153.92) in nonfatal cases. Similar observations were also made with respect to the TNF levels in the CSF; the mean of fatal cases was 69.39 pg/ ml (SD 39.00) in contrast to the mean of 62.41 pg/ml (SD 75.25) of nonfatal cases. The increase in TNF levels did not show any correlation to the duration of illness. The mortality rate increased with increasing concentrations of TNF in the serum and CSF. Correlation of laboratory parameters to final outcome revealed that TNF concentrations above 50 pg/ml in serum correlated significantly (P = 0.05) with a fatal outcome, whilst high levels of JE virus IgM antibodies (>500 units) in the CSF correlated with a nonfatal outcome (P = 0.03). These results suggest that TNF can be used as a possible prognosticator of a fatal outcome in JE virus infection. KW - arboviruses KW - cerebrospinal fluid KW - clinical aspects KW - cytokines KW - human diseases KW - immune response KW - Japanese encephalitis KW - nervous system diseases KW - serum KW - tumour necrosis factor KW - Asia KW - India KW - Karnataka KW - Japanese encephalitis virus KW - man KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - arthropod-borne viruses KW - cachectin KW - cachexin KW - clinical picture KW - immunity reactions KW - immunological reactions KW - Mysore KW - neuropathy KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504233&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine regulation of schistosome-induced granuloma and fibrosis. AU - Wahl, S. M. AU - Frazier-Jessen, M. AU - Jin, W. W. AU - Kopp, J. B. AU - Sher, A. AU - Cheever, A. W. JO - Kidney International JF - Kidney International Y1 - 1997/// VL - 51 IS - 5 SP - 1370 EP - 1375 SN - 0085-2538 AD - Wahl, S. M.: Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4352, USA. N1 - Accession Number: 19980800387. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 130068-27-8, 207137-56-2, 76057-06-2. Subject Subsets: Helminthology N2 - Eggs of Schistosoma mansoni trigger a granulomatous inflammatory reaction; the egg antigens are eliminated slowly and the persistent granulomatous response leads to prolonged matrix synthesis and hepatic fibrosis. In mice, soluble egg antigens (SEA) induced interleukin (IL)-4 synthesis, promoting a dominant T helper type 2 lymphocyte accumulation with the release of additional cytokines (IL-5, IL-10) which suppressed Th1 lymphocyte subset cytokines and mediated the characteristic pathophysiology. Manipulation of the cytokine profile with antagonists or exogenous cytokine delivery altered the course of hepatic inflammation and fibrosis. During the granulomatous response, transforming growth factor (TGF)-β was also produced which may have modulated inflammation and regulated fibrogenesis. In TGF-β1-gene targeted mutant mice that over-expressed TGF-β1 (TGF-β1 transgenics) or in which TGF-β1 had been inactivated (TGF-β1-/-; null mutation) or partially inactivated (TGF-β1+/-; null mutation heterozygotes), the altered production of TGF-β1 impacted on S. mansoni granuloma and hepatic fibrosis. Thus, in addition to the Th1/Th2 cytokine balance, modulation of TGF-β1 may change the outcome of chronic inflammatory fibrotic disease. KW - antigens KW - cytokines KW - experimental infections KW - fibrosis KW - granuloma KW - helminth ova KW - helminths KW - immune response KW - inflammation KW - interleukin 10 KW - interleukin 4 KW - interleukin 5 KW - laboratory animals KW - liver KW - liver diseases KW - mutants KW - parasites KW - pathogenesis KW - pathology KW - schistosomiasis KW - T lymphocytes KW - transforming growth factor KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - antigenicity KW - bilharzia KW - bilharziasis KW - immunity reactions KW - immunogens KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800387&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoic acid as a therapy for emphysema? AU - DeLuca, L. M. AU - Ross, S. A. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1997/// VL - 55 IS - 8 SP - 307 EP - 308 SN - 0029-6643 AD - DeLuca, L. M.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37, Room 3A-17, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19971410643. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - The beneficial role of retinoic acid in emphysema is discussed. KW - respiratory diseases KW - retinoic acid KW - reviews KW - therapy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - lung diseases KW - therapeutics KW - tretinoin KW - vitamin A acid KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410643&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular differences between several species of Strongyloides and comparison of selected isolates of S. stercoralis using a polymerase chain reaction-linked restriction fragment length polymorphism approach. AU - Srinivasan Ramachandran AU - Gam, A. A. AU - Neva, F. A. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1997/// VL - 56 IS - 1 SP - 61 EP - 65 SN - 0002-9637 AD - Srinivasan Ramachandran: Clinical Parasitology Unit, Laboratory of Parasitic Diseases, Building 4, Room 126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19970802588. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Helminthology N2 - The relationships between the parasitic nematodes of medical importance belonging to the genus Strongyloides were studied using a polymerase chain reaction (PCR)-linked restriction fragment length polymorphism approach. Several human and dog isolates of S. stercoralis, a monkey isolate of S. fuelleborni, and S. ratti, a rodent parasite, were used. The molecular analysis was based on amplification of the internal transcribed spacer and the 5′ portion of the 23S-like rRNA gene followed by restriction enzyme digests. The length of the PCR product was specific to each species and varied around 1.5 kilobase pairs. Using 9 restriction enzymes, both interspecific and intraspecific variations were analysed. With 4 restriction enzymes (Taq I, Dde I, Dra I and Mwo I), human isolates of S. stercoralis from different parts of the world showed identical patterns and could be differentiated from the dog isolate of S. stercoralis. Interspecific differences were readily observed with these and other enzymes. In addition to providing new information on the genomic characteristics of Strongyloides parasites, the results suggest that this technique could be useful for diagnostic and epidemiological investigations. KW - helminths KW - molecular genetics KW - molecular taxonomy KW - parasites KW - polymerase chain reaction KW - restriction fragment length polymorphism KW - Nematoda KW - Rhabditida KW - Strongyloides KW - Strongyloides fuelleborni KW - Strongyloides ratti KW - Strongyloides stercoralis KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Strongyloididae KW - Rhabditida KW - Strongyloides KW - biochemical genetics KW - nematodes KW - parasitic worms KW - PCR KW - RFLP KW - Secernentea KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802588&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of malaria parasite RNA from decade-old Giemsa-stained blood smears and dried mosquitoes. AU - Li, J. AU - Wirtz, R. A. AU - McCutchan, T. F. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1997/// VL - 57 IS - 6 SP - 727 EP - 731 SN - 0002-9637 AD - Li, J.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19980803048. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology N2 - RNA isolated from recently prepared and historically preserved slides containing smears of Plasmodium-infected blood was analysed. It was demonstrated that slides preserved for as long as 20 years could yield RNA that was a suitable template for polymerase chain reaction (PCR) amplification. Mosquitoes that had been stored for a number of years under ambient temperature could also be used as an RNA source. The RNA amplification from slide-derived material was shown to be dependent on the addition of reverse transcriptase, and the resultant products were specific to the developmental stage of the parasite. Amplification of ribosomal RNA with primers conserved for Plasmodium and hybridization with species-specific probes provided a general, unbiased method for species determination. Messenger RNA transcripts from slides also appeared to serve as templates. It is suggested that this procedure may add complementary information to that derived from microscopic examination of Giemsa-stained blood smears including species identification, variant antigen identification and drug resistance status. KW - analysis KW - blood KW - diagnosis KW - malaria KW - nucleotide sequences KW - parasites KW - polymerase chain reaction KW - ribosomal RNA KW - RNA KW - smears KW - Anopheles KW - Culicidae KW - Diptera KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - DNA sequences KW - mosquitoes KW - PCR KW - ribonucleic acid KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803048&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity. AU - Turley, J. M. AU - Ruscetti, F. W. AU - Kim SeongJin AU - Fu Tao AU - Gou, F. V. AU - Birchenall-Roberts, M. C. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1997/// VL - 57 IS - 13 SP - 2668 EP - 2675 SN - 0008-5472 AD - Turley, J. M.: Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA. N1 - Accession Number: 19971410904. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Registry Number: 59-02-9, 1406-18-4. Subject Subsets: Human Nutrition N2 - Vitamin E succinate (VES) inhibited the proliferation of the oestrogen receptor-negative human breast cancer cell line, BT-20, in the G1 phase of the cell cycle. Overexpression of E2F-1 blocked the ability of VES to inhibit BT-20 cell growth, suggesting that VES regulation of E2F-1 activity leads to growth arrest of BT-20 cells, VES, although having little effect on E2F-1 steady-state protein concentration, decreased E2F-1 phosphorylation and transactivation activity and increased cyclin A binding to E2F-1. GAL4-E2F-1 deletion mutant studies indicated that cyclin A negatively regulates E2F function. In VES-treated BT-20 cells, the cyclin A protein exhibited reduced kinase activity, which correlated with decreased steady-state concentrations and binding of cyclin-dependent kinase-2 to cyclin A and increased steady-state concentrations and binding of p21cip1 to cyclin A and cyclin-dependent kinase-2. The functional consequence of the negative regulatory effect of VES on E2F-1 function was shown by the ability of VES to inhibit the transcriptional activation of an E2F-1 responsive gene, c-myc. These studies show that VES induces growth inhibition of BT-20 cells through a mechanism that involves cyclin A-negative regulation of E2F-mediated transcription. KW - alpha-tocopherol KW - antineoplastic agents KW - breast cancer KW - cell cultures KW - cell growth KW - gene expression KW - inhibition KW - mammary gland neoplasms KW - neoplasms KW - transcription KW - vitamin e KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cell elongation KW - cytotoxic agents KW - DNA transcription KW - mammary tumour KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice. AU - Hursting, S. D. AU - Perkins, S. N. AU - Brown, C. C. AU - Haines, D. C. AU - Phang, J. M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1997/// VL - 57 IS - 14 SP - 2843 EP - 2846 SN - 0008-5472 AD - Hursting, S. D.: Laboratory of Nutritional and Molecular Regulation, Division of Basic Sciences, National Cancer Institute, NIH, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19971411225. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - Energy restriction (ER) delays spontaneous carcinogenesis in p53-deficient (p53-/-) mice, suggesting that ER modulates carcinogenesis by p53-independent mechanisms. To further evaluate the role of p53, tumour development was monitored in p53-/- and wild-type (p53+/+) mice fed ad libitum (AL) or an ER regimen (60% of AL energy intake). ER delayed tumour mortality in p53-/- and p53+/+ mice (mean time to death, 169 and 648 days, respectively) relative to AL feeding (104 and 470 days). The estimated age-specific cancer death rate AL:ER ratios were 4.3 for p53-/- mice and 4.4 for p53+/+ mice. Thus, despite the accelerated onset of carcinogenesis in p53-/- mice, the tumour-delaying effect of ER was similar in the two genotypes. KW - carcinogenesis KW - energy deprivation KW - energy intake KW - food restriction KW - genotypes KW - neoplasms KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411225&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. AU - Fay, M. P. AU - Freedman, L. S. AU - Clifford, C. K. AU - Midthune, D. N. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1997/// VL - 57 IS - 18 SP - 3979 EP - 3988 SN - 0008-5472 AD - Fay, M. P.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, 6130 Executive Blvd. MSC 7354, Bethesda, Maryland 20892-7354, USA. N1 - Accession Number: 19981400109. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Subject Subsets: Human Nutrition N2 - A meta-analysis was performed on data extracted from 97 reports of experiments, involving a total of 12 803 mice or rats, studying the effect on mammary tumour incidence of different types of dietary fatty acids. Fatty acids were categorized into saturated, monounsaturated, n-6 polyunsaturated and n-3 polyunsaturated. The relation between tumour incidence and percentage of total energy from these fatty acids was modelled using conditional logistic regression and allowing for varying effects between experiments, and for each fatty acid the effect of substituting the fatty acid energy for nonfat energy was estimated. The n-6 PUFA had a strong tumour-enhancing effect and saturated fats had a weaker tumour-enhancing effect. The n-3 PUFA had a small protective effect that was not significant. There was no significant effect of monounsaturated fats. The n-6 PUFA had a stronger tumour-enhancing effect at levels under 4% of total energy, but an effect is still present at intake levels greater than 4% of energy. In addition, when the intake of n-6 PUFA was at least 4% of energy, the n-6 PUFA effect remained stronger than the saturated fat effect. KW - development KW - energy intake KW - fats KW - fatty acids KW - intake KW - mammary gland neoplasms KW - monoenoic fatty acids KW - polyenoic fatty acids KW - reviews KW - saturated fatty acids KW - mice KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - monounsaturated fatty acids KW - polyunsaturated fatty acids KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. AU - Dunn, S. E. AU - Kari, F. W. AU - French, J. AU - Leininger, J. R. AU - Travlos, G. AU - Wilson, R. AU - Barrett, J. C. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1997/// VL - 57 IS - 21 SP - 4667 EP - 4672 SN - 0008-5472 AD - Dunn, S. E.: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19981402345. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 61912-98-9. Subject Subsets: Human Nutrition N2 - Insulin-like growth factor I (IGF-I) is lowered during dietary restriction (DR) in man and rats. As IGF-I modulates cell proliferation, apoptosis and tumorigenesis, the mechanisms behind the protective effects of DR may depend on the reduction of this multifaceted growth factor. To examine this hypothesis, IGF-I was restored during DR to ascertain if lowering of IGF-I was central to slowing bladder cancer progression during DR. Heterozygous p53-deficient mice received a bladder carcinogen, p-cresidine, to induce preneoplasia. After confirmation of bladder urothelial preneoplasia, the mice were divided into 3 groups: ad libitum; 20% DR; and 20% DR plus IGF-I (IGF-I/DR). Serum IGF-I was lowered 24% by DR but was completely restored in the IGF-I/DR-treated mice using recombinant IGF-I administered via osmotic minipumps. Although tumour progression was decreased by DR, restoration of IGF-I serum concentrations in DR-treated mice increased the stage of the cancers. Furthermore, IGF-I modulated tumour progression independent of changes in body weight. Rates of apoptosis in the preneoplastic lesions were 10 times higher in DR-treated mice compared with those in IGF/DR- and ad libitum-treated mice. Administration of IGF-I to DR-treated mice also stimulated cell proliferation 6-fold in hyperplastic foci. It was concluded that DR lowered IGF-I concentrations, thereby favouring apoptosis over cell proliferation and ultimately slowing tumour progression. KW - apoptosis KW - bladder KW - carcinogenesis KW - energy intake KW - food restriction KW - insulin-like growth factor KW - neoplasms KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - somatomedin C KW - urinary bladder KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402345&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Natural products in drug discovery and development. AU - Cragg, G. M. AU - Newman, D. J. AU - Snader, K. M. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1997/// VL - 60 IS - 1 SP - 52 EP - 60 SN - 0163-3864 AD - Cragg, G. M.: Natural Products Branch, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19970303849. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - The importance of natural products in drug discovery and development is evaluated with reference to data on new drugs to combat cancer and infectious diseases approved by either the United States Food and Drug Administration or comparable entities in other countries and reported mainly in the Annual Reports of Medicinal Chemistry during 1984-94, and potential anticancer compounds reported to be in the pre-New Drug Application phase up to the end of 1995. Data is presented in the following classes: (B) biologics (vaccines and monoclonals derived from mammalian sources); (N) derived from an unmodified natural product source; (ND) derived from a natural product source; (S) synthetic source; and (S*) synthetic source, but modelled on a natural product parent. Drugs are listed with disease indication, generic name and references. Some chemical structures are also presented. KW - anticancer properties KW - biological activity KW - chemical structure KW - medicinal plants KW - medicinal properties KW - natural products KW - plant composition KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - anti-cancer properties KW - bioactivity KW - chemical constituents of plants KW - drug plants KW - medicinal herbs KW - officinal plants KW - United States of America KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Pesticides and Drugs (General) (HH400) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970303849&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii. AU - Groweiss, A. AU - Cardellina, J. H., II AU - Pannell, L. K. AU - Uyakul, D. AU - Kashman, Y. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1997/// VL - 60 IS - 2 SP - 116 EP - 121 SN - 0163-3864 AD - Groweiss, A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19970304352. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Forestry N2 - Two novel natural products, lanneaquinol and 2′(R)-hydroxylanneaquinol, were isolated from the organic extract of fruits, leaves, stems and twigs of L. welwitschii (collected from Cameroon in 1987). Their structures were solved by spectroanalytical methods and confirmed by comparison to synthetic models. The absolute configuration of 2′(R)-hydroxylanneaquinol was determined by the modified Mosher method. Both compounds exhibited modest cytotoxicity against the NCI panel of 60 human tumour cell lines. The structures of 2 isomeric 4,5-dihydroxy-5-alkyl-2-cyclohexenones, which appear to be biogenetic precursors of the novel hydroquinones, were also elucidated. KW - cell lines KW - chemical structure KW - cytotoxic compounds KW - cytotoxicity KW - fruits KW - leaves KW - medicinal plants KW - plant composition KW - quinones KW - stems KW - Cameroon KW - Anacardiaceae KW - Lannea KW - man KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Anacardiaceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Lannea KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - chemical constituents of plants KW - drug plants KW - Lannea welwitschii KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970304352&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms. AU - McKee, T. C. AU - Bokesch, H. R. AU - McCormick, J. L. AU - Rashid, M. A. AU - Spielvogel, D. AU - Gustafson, K. R. AU - Alavanja, M. M. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1997/// VL - 60 IS - 5 SP - 431 EP - 438 SN - 0163-3864 AD - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19970306393. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Agroforestry N2 - Seven new cytotoxic isomalabaricane triterpenes were isolated from a sponge Stelletta sp. (collected from Australia), 2 anti-HIV [human immunodeficiency virus] pterocarpans and 6 isoflavanoids were isolated from 2 tropical plants in the genus Erythrina (bark of E. glauca collected from Guatemala; roots of E. lysistemon collected from Tanzania), and 3 anti-HIV enniatins were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fibre assay. KW - antiviral plants KW - antiviral properties KW - bark KW - characterization KW - chemical structure KW - cytotoxic compounds KW - cytotoxicity KW - human immunodeficiency viruses KW - isoflavonoids KW - isolation KW - medicinal plants KW - medicinal properties KW - multipurpose trees KW - phenolic compounds KW - roots KW - trees KW - woody plants KW - Australia KW - Guatemala KW - Tanzania KW - Alternaria KW - Erythrina KW - Erythrina fusca KW - Fusarium KW - Papilionoideae KW - plants KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Pleosporaceae KW - Pleosporales KW - Dothideomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Papilionoideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Erythrina KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - CACM KW - Central America KW - America KW - Developing Countries KW - Latin America KW - ACP Countries KW - Anglophone Africa KW - Africa KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - SADC Countries KW - anti-viral properties KW - drug plants KW - Erythrina glauca KW - Erythrina lysistemon KW - fungus KW - human immunodeficiency virus KW - Hyphomycetes KW - medicinal herbs KW - officinal plants KW - Stelletta KW - Tanganyika KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-wood Forest Products (KK540) KW - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970306393&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. AU - Hallock, Y. F. AU - Manfredi, K. P. AU - Dai JinRui AU - Cardellina, J. H., II AU - Gulakowski, R. J. AU - McMahon, J. B. AU - Schäffer, M. AU - Stahl, M. AU - Gulden, K. P. AU - Bringmann, G. AU - François, G. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1997/// VL - 60 IS - 7 SP - 677 EP - 683 SN - 0163-3864 AD - Hallock, Y. F.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19970308516. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Protozoology N2 - New monomeric (korupensamine E) and dimeric (michellamines D-F) naphthylisoquinoline alkaloids were isolated from extracts of leaves of the tropical liana A. korupensis (collected from Cameroon). Their structures were determined from spectral data and chemical degradation. Michellamines D-F exhibited in vitro HIV [human immunodeficiency virus]-inhibitory activity comparable to that of michellamine B (EC50 values of 2-6 µM). Korupensamine E exhibited in vitro antimalarial activity (against Plasmodium falciparum) comparable to that of korupensamines A-D (IC50 value of 2 µg/ml). KW - alkaloids KW - antimalarials KW - antiprotozoal agents KW - antiprotozoal properties KW - antiviral plants KW - antiviral properties KW - biological activity KW - chemical structure KW - human immunodeficiency viruses KW - in vitro KW - isoquinoline alkaloids KW - leaves KW - medicinal plants KW - parasites KW - plant composition KW - plant extracts KW - Cameroon KW - Ancistrocladaceae KW - Ancistrocladus KW - Ancistrocladus korupensis KW - plants KW - Plasmodium falciparum KW - protozoa KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Ancistrocladaceae KW - Ancistrocladus KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - anti-protozoal properties KW - anti-viral properties KW - bioactivity KW - chemical constituents of plants KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Plant Composition (FF040) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970308516&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. AU - Deitsch, K. W. AU - Moxon, E. R. AU - Wellems, T. E. JO - Microbiological and Molecular Biology Reviews JF - Microbiological and Molecular Biology Reviews Y1 - 1997/// VL - 61 IS - 3 SP - 281 EP - 293 AD - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970806170. Publication Type: Journal Article. Language: English. Number of References: 192 ref. Subject Subsets: Protozoology; Medical & Veterinary Mycology N2 - This review begins with a description of some biological forms of antigenic variation and their effects on the virulence of Trypanosoma brucei, Plasmodium falciparum, Neisseria meningitidis, N. gonorrhoeae, Haemophilus influenzae, Borrelia spp., and Candida albicans. Common characteristics of hypermutable genetic loci which mediate the high rates of phenotypic variation are explored, and genetic mechanisms responsible for such variations are described and depicted diagrammatically. These include phase variation, gene conversion, point mutation, and genomic rearrangement. KW - antigenic variation KW - gene conversion KW - genes KW - immune evasion KW - loci KW - molecular genetics KW - mutations KW - parasites KW - phenotypic variation KW - reviews KW - virulence KW - Borrelia KW - Candida albicans KW - Haemophilus influenzae KW - Neisseria gonorrhoeae KW - Neisseria meningitidis KW - Plasmodium falciparum KW - protozoa KW - Trypanosoma brucei KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Haemophilus KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Proteobacteria KW - Neisseria KW - Neisseriaceae KW - Neisseriales KW - Betaproteobacteria KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - antigenic polymorphism KW - bacterium KW - biochemical genetics KW - fungus KW - genomic rearrangement KW - Hyphomycetes KW - Meningococcus KW - phase variation KW - phenotypic variability KW - point mutations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970806170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activity measures in rhesus monkeys on long-term calorie restriction. AU - Weed, J. L. AU - Lane, M. A. AU - Roth, G. S. AU - Speer, D. L. AU - Ingram, D. K. JO - Physiology & Behavior JF - Physiology & Behavior Y1 - 1997/// VL - 62 IS - 1 SP - 97 EP - 103 SN - 0031-9384 AD - Weed, J. L.: Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute of Aging National Institutes of Health, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD, USA. N1 - Accession Number: 19971409826. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition N2 - Energy restriction (ER), undernutrition without malnutrition, extends the mean and maximal lifespan of several ecologically diverse species. Rodents on ER demonstrate increased activity measured as spontaneous locomotion, wheel running, open field behaviour or movement. Activity measures were recorded from 19 male rhesus monkeys (Macaca mulatta) as controls (C) which were fed on a nutritious diet to approximate ad libitum levels, or as experimentals (E) which were fed 30% less than age- and weight-matched controls. Within each diet group, some monkeys (n=10) began ER at 2.3 years of age (range 2.2-2.4 years, J Group) while another group (n=9) began ER at about 4.6 years of age (range 4-5.25, A group). Beginning about 6 years after initiation of the study, behavioural activity was measured via ultrasonic motion detectors and recorded on videotape. Diurnal and circadian activity was clearly discernible. Peaks in activity were associated with mealtime and colony husbandry. Compared to Group A, Group J monkeys exhibited higher overall activity as measured by sensors, and also significantly more circling. Compared to AC monkeys, group AE monkeys demonstrated higher rates of gross motor behaviour, pacing, stereotypies and grooming. The increases in motor activity observed in one group of monkeys were consistent with results obtained from rodent studies of ER and aging. ER did not significantly inhibit or negatively influence the display of behaviour of rhesus monkeys in the laboratory environment. KW - activity KW - aging KW - behaviour KW - diet KW - energy deprivation KW - physical activity KW - macaca mulatta KW - monkeys KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - behavior KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409826&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Developmental differences determine larval susceptibility to nitric oxide-mediated killing in a murine model of vaccination against Schistosoma mansoni. AU - Ahmed, S. F. AU - Oswald, I. P. AU - Caspar, P. AU - Hieny, S. AU - Keefer, L. AU - Sher, A. AU - James, S. L. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 1 SP - 219 EP - 226 SN - 0019-9567 AD - Ahmed, S. F.: Parasitology and International Programs Branch, Solar Building, Room 3A-10, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7630, USA. N1 - Accession Number: 19970801070. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 10102-43-9. Subject Subsets: Helminthology; Tropical Diseases N2 - In Schistosoma mansoni infection in animals vaccinated with attenuated parasites, attrition of challenge parasites occurs during migration through the lungs in vivo although parasites recovered from the lungs appear to be relatively resistant to cytotoxic effector mechanisms in vitro. The susceptibilities were compared of different stages of larvae to killing by nitric oxide (NO), which has previously been shown to be involved in the larvicidal function of cytokine-activated cytotoxic effector cells. Lung-stage larvae obtained 1 week after infection of mice with 3000 cercariae were not killed in vitro by NO generated either by a chemical NO donor or by activated cells. In contrast, parasites obtained from the portal system of control mice or from the lungs of vaccinated mice 2.5 weeks following challenge infection were killed by NO. As previously shown for mammalian cell targets, the effects of NO in susceptible larval stages may involve enzymes required for aerobic energy metabolism, since similar cytotoxicity was demonstrated by chemical inhibitors of the citric acid cycle or mitochondrial respiration. Together with previous observations of enhanced Th1 activity and expression of NO synthase in the lungs of vaccinated mice at 2.5 weeks after challenge infection, these observations elucidate the immune mechanism of vaccine-induced resistance to S. mansoni infection and suggest that conversion to a less metabolically active state may allow pathogens to escape the effects of the important effector molecule NO. KW - animal models KW - digenean larvae KW - experimental infections KW - helminths KW - immunity KW - immunization KW - in vitro KW - laboratory animals KW - lungs KW - metabolism KW - nitric oxide KW - parasites KW - resistance KW - schistosomiasis KW - T lymphocytes KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immune sensitization KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801070&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum. AU - Zhou Ping AU - Sieve, M. C. AU - Tewari, R. P. AU - Seder, R. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 3 SP - 936 EP - 942 SN - 0019-9567 AD - Zhou Ping: Lymphokine Regulation Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971200684. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The immunomodulatory effects of interleukin-12 (IL-12) on disseminated histoplasmosis in immunodeficient SCID mice were examined. SCID mice infected with H. capsulatum and treated with IL-12 showed an increase in survival and a reduction in the colony counts of H. capsulatum in internal organs at 14 days after infection. The protective effect of IL-12 was abrogated if animals were also treated with a neutralizing antibody to gamma interferon (IFN-γ). IL-12 treatment also resulted in an increase in mRNA expression and protein production for IFN-γ, tumor necrosis factor alpha (TNF-α) and nitric oxide from spleen cells. When IL-12 was combined with amphotericin B (AmB) treatment, there was a significant increase in survival compared with either modality alone. Moreover, combined treatment resulted in an increase in both IFN-γ and TNF-α production, as well as in a substantial reduction in H. capsulatum burden at 35 and 90 days postinfection. It is concluded that IL-12 modulates the protective immune response to histoplasmosis in SCID mice and that IL-12 in combination with AmB may be useful as a treatment for H. capsulatum in immunodeficient hosts. KW - amphotericin B KW - antifungal agents KW - drug therapy KW - experimental infections KW - fungicides KW - histoplasmosis KW - immune response KW - immunocompromised hosts KW - immunology KW - immunosuppression KW - immunotherapy KW - infections KW - interleukins KW - opportunistic infections KW - predisposition KW - synergism KW - therapy KW - Histoplasma capsulatum KW - mice KW - Histoplasma KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Ajellomyces KW - Ajellomyces capsulatus KW - chemotherapy KW - fungistats KW - fungus KW - immunity reactions KW - immunological reactions KW - synergy KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200684&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines. AU - Duffy, P. E. AU - Kaslow, D. C. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 3 SP - 1109 EP - 1113 SN - 0019-9567 AD - Duffy, P. E.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA. N1 - Accession Number: 19980801708. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases; Medical & Veterinary Entomology N2 - Alignment of the sequences of the Plasmodium surface proteins Pfs25 (from P. falciparum), Pgs25 and Pgs28 (from P. gallinaceum) revealed areas of nucleotide similarity which were used to produce a polymerase chain reaction probe to find Pfs28, which was sequenced from 7 laboratory strains of P. falciparum. The genes for Pfs25 and Pfs28 were found to be closely linked. Antibodies to Pfs28 blocked infectivity of Plasmodium falciparum in Anopheles freeborni, and when combined with antibodies to Pfs25 provided synergy in blocking transmission. In conclusion, Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine. The deduced amino acid sequence of Pfs28 has been submitted to GenBank under accession number L25843. KW - amino acid sequences KW - antigens KW - disease transmission KW - gene location KW - genes KW - genetics KW - human diseases KW - infectivity KW - linkage KW - malaria KW - nucleotide sequences KW - parasites KW - polymerase chain reaction KW - surface antigens KW - vaccine development KW - Culicidae KW - Diptera KW - man KW - Plasmodium falciparum KW - protozoa KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - antigenicity KW - DNA sequences KW - immunogens KW - monosomic analysis KW - mosquitoes KW - nullisomic analysis KW - PCR KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ad libitum food intake in humans after manipulation of glycogen stores. AU - Snitker, S. AU - Larson, D. E. AU - Tataranni, P. A. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 4 SP - 941 EP - 946 SN - 0002-9165 AD - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 5-41, Phoenix, AZ 85016, USA. N1 - Accession Number: 19971406297. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9005-79-2. Subject Subsets: Human Nutrition N2 - In 8 white men with a mean SD) age of 30±4 years, body weight of 82±20 kg, and percentage body fat of 22±5%, exercise and diets were used to produce high (HG) or low glycogen (LG) stores in a randomized crossover design. After each treatment, a vastus lateralis muscle biopsy was obtained. Subsequent ad libitum food intake was measured with an automated food-selection system during 2 days in a respiratory chamber. Despite a 46±21% difference in muscle glycogen between the two treatments, ad libitum 2-day food intakes (energy, weight or macronutrients) were similar between treatments (HG 23.80±4.67; LG 21.20±6.73 MJ/day). However, energy intake on the second day of ad libitum feeding was negatively correlated with carbohydrate balance on the first day, adjusted for the effect of total energy intake and treatment. Adjusted carbohydrate balance on day 1 only explained 9% of the variance in energy intake on day 2. The 24-h respiratory quotient on the first day after treatment was higher after the HG than after the LG treatment: 0.94±0.04 and 0.88±0.07 (P<0.001). The findings suggest that body glycogen stores play at most a minor role in short-term food intake regulation, and in the short term, imbalances in glycogen stores are corrected by adjustments of macronutrient oxidation rates. KW - carbohydrates KW - diet KW - energy metabolism KW - food intake KW - glycogen KW - men KW - skeletal muscle KW - stores KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - saccharides KW - storage structures KW - storehouses KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971406297&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of a new vitamin C-deficient diet in a depletion-repletion clinical trial. AU - King, J. AU - Wang YaoHui AU - Welch, R. W. AU - Dhariwal, K. R. AU - Conry-Cantilena, C. AU - Levine, M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 5 SP - 1434 EP - 1440 SN - 0002-9165 AD - King, J.: Department of Nutrition, Diabetes Branch, National Institutes of Health, Bethesda, MD 20892-1372, USA. N1 - Accession Number: 19971406697. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 50-81-7, 7439-89-6. Subject Subsets: Human Nutrition N2 - To examine the recommended dietary allowance (RDA) for ascorbic acid, a unique ascorbic acid-deficient diet was developed using a nutrient database and selective menus. 14 different menus were developed offering >300 items containing ascorbic acid 0-2.4 mg/serving. Seven healthy male volunteers were hospitalized for 116-180 days and daily dietary ascorbic acid was restricted to ≤5.0 mg using the newly developed diet. Mean daily dietary ascorbic acid intake was <3.9 mg for the 7 subjects. With concurrent supplementation, the diet provided ≥85% of the RDA for 17 essential nutrients. Within 3 weeks of admission, the diet induced ascorbic acid deficiency as indicated by plasma concentrations, which decreased from 23±6.9 to 6.9±2.0 µmol/litre. Daily intake of ascorbic acid and 5 other nutrients was estimated by nutrient database analyses. Mean energy, protein and iron were 105-185% of the RDA and total and saturated fat were 32% and 10% of energy, respectively. Weight and nutritionally relevant indexes remained normal. Dietary adherence, calculated by the number of days with ≤5.0 mg ascorbic acid per total study days, was 88-98% per repletion dose. Computer analyses of menu selections permitted individual preferences to be met while restricting ascorbic acid intake to ≤5.0 mg/day. There were no complications from the diet during the depletion and repletion phases. It was concluded that using this diet, ascorbic acid pharmacokinetics for escalating doses could be estimated in healthy volunteers. KW - ascorbic acid KW - databases KW - deficiency KW - diet KW - energy intake KW - iron KW - men KW - nutrients KW - pharmacokinetics KW - protein KW - recommended dietary allowances KW - saturated fats KW - trace elements KW - vitamin deficiencies KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - data banks KW - microelements KW - RDA KW - recommended dietary intakes KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971406697&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 gene. AU - Chang, Y. C. AU - Cherniak, R. AU - Kozel, T. R. AU - Granger, D. L. AU - Morris, L. C. AU - Weinhold, L. C. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 5 SP - 1584 EP - 1592 SN - 0019-9567 AD - Chang, Y. C.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971201195. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Medical & Veterinary Mycology N2 - An encapsulated C. neoformans strain, TYCC38-602, was created by transforming C. neoformans strain 602 (an acapsular clinical isolate) with the CAP64 gene which was isolated from a serotype D strain. Serological tests and chemical analysis of the major polysaccharide capsule of TYCC38-602 indicated that strain 602 was originally derived from a serotype A strain. Restoration of the ability to produce a capsule enabled strain 602 to cause fatal infection in mice, whereas the acapsular strain 602 remained avirulent. Capsule-restored yeast cells of strain 602 activated the human complement system and bound C3 fragments in a manner characteristic of encapsulated cryptococci. In addition, the capsule in TYCC38-602 masked the ability of the organism to induce tumour necrosis factor-α and subsequent nitric oxide synthase production in primed macrophage-like cells. The results indicated that the lack of capsule in strain 602 is the reason for its inability to cause fatal infection. The acapsular phenotype accounts for differences in various biological activities of strain 602 compared with encapsulated strains. The results also indicated that the gene product of CAP64 does not contribute to serotype specificity of capsules in C. neoformans. KW - cryptococcosis KW - experimental infections KW - genes KW - genetics KW - infections KW - pathogenicity KW - serotypes KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - capsule KW - european blastomycosis KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201195&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis. AU - Siddartha Mahanty AU - Manickam Ravichandran AU - Uma Raman AU - Kunthala Jayaraman AU - Kumaraswami, V. AU - Nutman, T. B. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 5 SP - 1742 EP - 1747 SN - 0019-9567 AD - Siddartha Mahanty: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980800158. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 9008-11-1, 130068-27-8. Subject Subsets: Helminthology N2 - The mechanisms by which interleukin-10 (IL-10) regulates antigen-specific hyporesponsiveness in asymptomatic microfilaraemic (MF) individuals were investigated. Peripheral blood mononuclear cells from 11 MF individuals in Madras, India were stimulated in vitro with Brugia malayi antigen (BMA) or mycobacterial purified protein derivative (PPD) in the presence of neutralizing anti-IL-10 or isotype control monoclonal antibodies. As expected, BMA stimulated little or no gamma interferon (IFN-γ) secretion in MF individuals as compared with controls, whereas PPD stimulated IFN-γ in all but one. Neutralization of endogenous BMA-driven IL-10 secretion led to augmentation (1.5- to 10-fold) of IFN-γ in 7 of 9 MF individuals, and did so in a BMA-specific manner (PPD-driven IFN-γ was augmented in only 2 of 8 MF individuals and only 1.5- to 2-fold), indicating that IL-10 downregulates type 1 responses in these individuals. Type 2 responses (IL-5 secretion) were unaffected by the IL-10 blockade. To assess whether IL-12 could reverse the type 1 downregulation observed, the effect of recombinant human IL-12 (rhIL-12) on BMA-driven IL-5 and IFN-γ production was also evaluated. rhIL-12 augmented both BMA- and PPD-driven IFN-γ production 5- to 10-fold in 6 of 9 MF individuals. These data demonstrate that IL-10 downregulates BMA-driven type 1 responses and that IL-12 can overcome downregulation of Th1 responses associated with microfilaraemia, but does so in a non-antigen-specific manner. KW - antigens KW - filariasis KW - helminths KW - human diseases KW - immune response KW - in vitro KW - interferon KW - interleukin 10 KW - interleukin 5 KW - interleukins KW - lymphatic filariasis KW - microfilariae KW - parasites KW - India KW - Tamil Nadu KW - Brugia malayi KW - man KW - Wuchereria bancrofti KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Wuchereria KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - Madras KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800158&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni. AU - Yap, G. AU - Cheever, A. AU - Caspar, P. AU - Jankovic, D. AU - Sher, A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 7 SP - 2583 EP - 2586 SN - 0019-9567 AD - Yap, G.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA. N1 - Accession Number: 19970803621. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - The granulomatous response to schistosome eggs is a CD4 T-cell-dependent, Th2-cytokine-dominated immunopathological response. As infection proceeds to chronicity, both granuloma formation and egg-induced cytokine production become downregulated and previous experiments have implicated CD8 T cells in this process. One mechanism by which CD8 T cells could suppress immunopathology is through the production of the counterregulatory cytokine gamma interferon (IFN-γ). To investigate this hypothesis, hepatic granuloma formation and egg-induced cytokine production were analysed in Schistosoma mansoni-infected gene knockout mice deficient in either CD8 lymphocytes or IFN-γ. It was found that neither immunological component played an essential function in the control of granuloma and cytokine responses during either the acute or chronic stage of infection. Other mechanisms may therefore be more important in the regulation of immunopathology in schistosomiasis. KW - acute course KW - chronic course KW - experimental infections KW - granuloma KW - helminth ova KW - helminths KW - immunopathology KW - interferon KW - laboratory animals KW - parasites KW - schistosomiasis KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - severe course KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970803621&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of protection induced by immunization with recombinant proteins from different regions of merozoite surface protein 1 of Plasmodium yoelii. AU - Tian JingHui AU - Sanjai Kumar AU - Kaslow, D. C. AU - Miller, L. H. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 8 SP - 3032 EP - 3036 SN - 0019-9567 AD - Tian JingHui: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19980802773. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - To determine which regions of Plasmodium merozoite surface protein 1 (MSP1) can induce protection against malaria, P. yoelii MSP1 was divided into 4 separate regions. Each was expressed in Escherichia coli as a fusion protein with glutathione S-transferase (GST). The N-terminal fragment began after the cleavage site for the signal sequence and ended in the region comparable to the cleavage site for the C terminus of the 82-kDa peptide of P. falciparum. This expressed protein was 30 kDa smaller than the predicted peptide. One peptide from the middle region was produced, and the C terminus consisted of a 42-kDa fragment corresponding to the analogous peptide of P. falciparum and a 19-kDa fragment that extended 37 amino acids in the amino-terminal direction beyond the probable cleavage site. Three mouse strains (CAF1, BALB/c, and A/J) were vaccinated with each of the 4 recombinant proteins of MSP1, and then challenged with potentially lethal doses of P. yoelii. Only 2 of 12 unvaccinated mice survived. Mice vaccinated with the C-terminal 19-kDa protein were highly protected, with 12 of 12 surviving, as were those vaccinated with the 42-kDa protein that contained the 19-kDa fragment (12 of 13 survived). The N-terminally expressed fragment of P. yoelii was not full-length because of proteolytic cleavage in E. coli; the GST-82-kDa partial fragments induced some immunity (9 of 12 survived), but the surviving mice still had high parasitaemias. Vaccination with the peptide from the middle region of MSP1 gave minimal or no protection (6 of 12 survived, with high parasitaemia). KW - animal diseases KW - experimental infections KW - human diseases KW - immunization KW - laboratory animals KW - laboratory mammals KW - malaria KW - parasites KW - recombinant antigens KW - recombinant vaccines KW - surface antigens KW - vaccine development KW - mice KW - Plasmodium yoelii KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - immune sensitization KW - merozoite surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802773&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A gene homologous to Saccharomyces cerevisiae SNF1 appears to be essential for the viability of Candida albicans. AU - Petter, R. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1997/// VL - 65 IS - 12 SP - 4909 EP - 4917 SN - 0019-9567 AD - Petter, R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19981200450. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The isolation and characterization of an SNF1 homologue from C. albicans (CaSNF1), which is apparently essential for the viability of this organism, are reported. The putative amino acid sequence of CaSNF1 had 68% identity with that of SNF1 of S. cerevisiae (ScSNF1) and could restore the S. cerevisiaesnf1Δ mutant's ability to utilize sucrose. Disruption of one of the CaSNF1 alleles resulted in morphological changes and decreased growth rates but did not modify the carbon source utilization pattern. Repetitive unsuccessful attempts to generate a snf1/snf1 homozygote by disruption of the second allele, using various vectors and approaches, suggested the lethal nature of this mutation. Integration into the second allele was possible only when a full-length functional SNF1 sequence was reassembled, further supporting this hypothesis and indicating that the indispensability of Snf1p prevented the isolation of snf1/snf1 mutants. The mutant bearing 2 disrupted SNF1 alleles and the SNF1 functional sequence maintained its ability to utilize sucrose and produced stellate colonies with extensive hyphal growth on agar media. It was demonstrated that in a mouse model, the virulences of this mutant and the wild-type strain were similar, suggesting that hyphal growth in vitro is not an indicator for higher virulence. KW - candidosis KW - experimental infections KW - genes KW - genetics KW - infections KW - pathogenicity KW - viability KW - Candida albicans KW - mice KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Saccharomyces KW - Saccharomycetaceae KW - candidiasis KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200450&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Randomized trials of sodium reduction: an overview. AU - Cutler, J. A. AU - Follmann, D. AU - Allender, P. S. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 2SUP SP - 643S EP - 651S SN - 0002-9165 AD - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971403449. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 50 + 1 ref. Registry Number: 7440-23-5. Subject Subsets: Human Nutrition N2 - This article reviews the evidence as to whether dietary sodium intake should be decreased to lower the risk of cardiovascular disease. More specifically the relationship between change in sodium intake and change in diastolic and systolic blood pressure is examined. Also briefly discussed is whether intake of dietary sodium can be decreased. KW - adults KW - blood pressure KW - cardiovascular diseases KW - clinical trials KW - hypertension KW - intake KW - minerals KW - reduction KW - restricted feeding KW - reviews KW - salt KW - sodium KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Dietary sodium and health KW - high blood pressure KW - metaanalysis KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403449&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Register of dietary assessment calibration-validation studies: a status report. AU - Thompson, F. E. AU - Moler, J. E. AU - Freedman, L. S. AU - Clifford, C. K. AU - Stables, G. J. AU - Willett, W. C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 4 Supp SP - 1142S EP - 1147S SN - 0002-9165 AD - Thompson, F. E.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Room 313, 6130 Executive Boulevard, MSC 7344, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19971405918. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 52 ref. Subject Subsets: Human Nutrition KW - assessment KW - calibration KW - diet study techniques KW - dietary surveys KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - registers KW - Second international conference on dietary assessment methods KW - Diet Studies (VV110) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405918&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comments on "adjustments for total energy intake in epidemiologic studies". AU - Freedman, L. S. AU - Kipnis, V. AU - Brown, C. C. AU - Schatzkin, A. AU - Wacholder, S. AU - Hartman, A. M. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 4 Supp SP - 1229S EP - 1231S SN - 0002-9165 AD - Freedman, L. S.: Biometry and Cancer Prevention Studies Branches, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7354, USA. N1 - Accession Number: 19971405967. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition KW - diet study techniques KW - energy KW - energy intake KW - epidemiology KW - methodology KW - nutrition KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - methods KW - Second international conference on dietary assessment methods KW - Diet Studies (VV110) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405967&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterizing food intake patterns of American adults. AU - Krebs-Smith, S. M. AU - Cleveland, L. E. AU - Ballard-Barbash, R. AU - Cook, D. A. AU - Kahle, L. L. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 65 IS - 4 Supp SP - 1264S EP - 1268S SN - 0002-9165 AD - Krebs-Smith, S. M.: National Cancer Institute, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19971405924. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition KW - adults KW - diet study techniques KW - food intake KW - fruit KW - patterns KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Second international conference on dietary assessment methods KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405924&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of supplemental β-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. AU - Albanes, D. AU - Virtamo, J. AU - Taylor, P. R. AU - Rautalahti, M. AU - Pietinen, P. AU - Heinonen, O. P. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 66 IS - 2 SP - 366 EP - 372 SN - 0002-9165 AD - Albanes, D.: National Cancer Institute, Executive Plaza North-Suite 211, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19971410949. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 59-02-9, 7235-40-7, 502-65-8, 127-40-2, 144-68-3. Subject Subsets: Human Nutrition N2 - It was determined whether serum carotenoid or retinol concentrations were altered by β-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use. Participants in this substudy were 491 men aged 58-76 years from the metropolitan Helsinki study centre (237 receiving supplemental β-carotene (20 mg/day) and 254 not receiving such supplementation). Dietary carotenoids, retinol, and alcohol, and serum β-carotene, α-tocopherol, retinol, and cholesterol were assessed at baseline. After an average of 6.7 years of supplementation, serum was collected and carotenoid, retinol and α-tocopherol concentrations were estimated by HPLC. Serum carotenoid fractions were highly correlated with each other (P≤0.0001). Compared with the unsupplemented group, the β-carotene group had higher serum concentrations of β-carotene (1483%), α-carotene (145%) and β-cryptoxanthin (67%) (P≤0.0001). Retinol concentrations were 6% higher (P=0.03) and lutein was 11% lower (P=0.02) in the supplemented group. Serum lycopene, zeaxanthin and α-tocopherol did not differ according to β-carotene-supplementation status. Although these β-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (>12.9 g/day, median) was related to lower (10-38%) concentrations of carotenoids, particularly β-carotene, α-carotene and β-cryptoxanthin, in the supplemented and unsupplemented groups. Smoking status did not significantly influence the supplementation-related differences in serum carotenoid and retinol values but concentrations of carotenoids were generally highest in participants who quit smoking while in the study and lowest in current smokers of ≥20 cigarettes/day. This study showed that serum concentrations of non-β-carotene carotenoids are altered by long-term β-carotene supplementation and confirms the adverse effects of alcohol and cigarette smoking on serum carotenoids. KW - alcohol intake KW - alcoholic beverages KW - alpha-tocopherol KW - beta-carotene KW - blood KW - carotenoids KW - lycopene KW - neoplasms KW - supplements KW - tobacco smoking KW - vitamins KW - xanthophyll KW - zeaxanthin KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - alcohol consumption KW - cancers KW - lutein KW - tetraterpenoids KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410949&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Carrying the burden of cardiovascular risk in old age: associations of weight and weight change with prevalent cardiovascular disease, risk factors, and health status in the Cardiovascular Health Study. AU - Harris, T. B. AU - Savage, B. J. AU - Tell, G. S. AU - Haan, M. AU - Kumanyika, S. AU - Lynch, J. C. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 66 IS - 4 SP - 837 EP - 844 SN - 0002-9165 AD - Harris, T. B.: Epidemiology, Demography and Biometry Program, National Institute on Aging, Gateway Building, Room 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892-9205, USA. N1 - Accession Number: 19981400087. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - Measured weight in old age, reported weight at 50 years old and weight change from 50 years old to old age were examined in association with prevalent cardiovascular disease (CVD), CVD risk factors and health status in 4954 men and women (≥ 65 years old) who were enrolled in the Cardiovascular Health Study (CHS). Heavier weight (i.e., generally weight in the fourth quartile for the cohort) at 50 years old was more closely associated with prevalent CVD than was current weight, with these associations stronger in women than in men. Heavier current weight and heavier weight at 50 years old were associated with cardiovascular risk factors, including higher blood pressure, lower HDL cholesterol and higher fasting insulin. Heavier weight at both time points was related to mobility problems in men and women and to lower current physical activity levels; among women, strong associations were also seen with lower education and current income. Remaining within 10% of reported weight at 50 years old was associated with better health status as measured by reported health, mobility difficulty, number of medications and prevalent CVD in men. Paradoxically, most cardiovascular risk factors were lowest for weight losers despite an association of weight loss with poorer health. It was concluded that, in this cohort of people aged ≥65 years, heavier weight was associated with CVD and CVD risk factors, suggesting that prevention of overweight may prove beneficial in improving cardiovascular risk in older persons. Weight stability from 50 years old to old age was associated with better health status than was weight gain or loss. KW - age KW - body weight KW - cardiovascular diseases KW - health KW - men KW - obesity KW - old age KW - risk factors KW - sex differences KW - weight reduction KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400087&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Consistency between US dietary fat intake and serum total cholesterol concentrations: the National Health and Nutrition Examination Surveys. AU - Ernst, N. D. AU - Sempos, C. T. AU - Briefel, R. R. AU - Clark, M. B. A2 - Rivlin, R. S JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1997/// VL - 66 IS - 4S SP - 965S EP - 972S SN - 0002-9165 AD - Ernst, N. D.: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19971412979. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 16 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Between the early 1970s and early 1990s there were 3 National Health and Nutrition Examination Surveys (NHANES) in the USA: NHANES I, 1971-1974; NHANES II, 1976-1980; and NHANES III, phase 1, 1988-1991. During the 18 years between the mid-point of NHANES I (1972) and the mid-point of phase 1 of NHANES III (1990), the age-adjusted mean percentage of energy from fat declined from 36.4 to 34.1% for adults aged 20-74 years. Trend data are shown in the paper for dietary fat and cholesterol as well as for serum cholesterol from NHANES I (1971-1975) to NHANES III (1988-1991) by age, sex and race-ethnicity. The results document a decline in dietary fat, saturated fat, dietary cholesterol and serum cholesterol. The observed changes reflect those that are predicted by the classic Keys and Hegsted formulas. Changes in reported intake are matched by similar shifts in the food supply for sources of these nutrients. These changes suggest that the Healthy People 2000 goal in the USA of reducing the mean serum cholesterol concentration of US adults to\less or equal\200 mg/100 ml (5.17 mmol/litre) is attainable. KW - adults KW - age differences KW - blood KW - cholesterol KW - diet studies KW - energy intake KW - ethnic groups KW - fat consumption KW - nutrition surveys KW - saturated fats KW - sex differences KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fats and oil consumption in health and disease KW - nutritional surveys KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412979&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A comparison of the incidence of severe malaria in Malian children with normal and C-trait hemoglobin profiles. AU - Guinet, F. AU - Diallo, D. A. AU - Minta, D. AU - Dicko, A. AU - Sissoko, M. S. AU - Keita, M. M. AU - Wellems, T. E. AU - Doumbo, O. JO - Acta Tropica JF - Acta Tropica Y1 - 1997/// VL - 68 IS - 2 SP - 175 EP - 182 SN - 0001-706X AD - Guinet, F.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20 892-0425, USA. N1 - Accession Number: 19970805572. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology; Tropical Diseases N2 - A survey of the haemoglobin profiles among children admitted to the Gabriel Touré Hospital in Bamako, Mali, with symptomatic and severe malaria was carried out between August and December 1994. All the children were aged between 6 months and 9 years and identification of Plasmodium falciparum was by Giemsa-stained thick blood films and blood smears. Electrophoresis was used to analyse the haemoglobin types of 169 children; children with AC (heterozygous state for HbA and HbC) and AA (homozygous state for HbA) profiles presented with severe malaria at comparable rates (99 of 149 cases of severe malaria in children with AA profiles; 11 of 16 cases of severe malaria in children with AC and SC profiles). Two children, one of whom presented with cerebral malaria, were found to have SC (heterozygous state for HbS and HbC) profiles. No CC (homozygous for HbC) profiles were detected in the study cohort. KW - blood KW - cerebral malaria KW - children KW - haemoglobin KW - haemoglobinopathies KW - human diseases KW - incidence KW - malaria KW - parasites KW - Mali KW - man KW - Plasmodium falciparum KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - ACP Countries KW - Francophone Africa KW - Africa KW - Least Developed Countries KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - haemoglobin C KW - hemoglobin KW - hemoglobinopathies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805572&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference. AU - Ward, M. H. AU - Sinha, R. AU - Heineman, E. F. AU - Rothman, N. AU - Markin, R. AU - Weisenburger, D. D. AU - Correa, P. AU - Zahm, S. H. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1997/// VL - 71 IS - 1 SP - 14 EP - 19 SN - 0020-7136 AD - Ward, M. H.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981403739. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition N2 - Telephone interviews were conducted with white men and women diagnosed with adenocarcinoma of the stomach (n=176) and oesophagus (n=143) between July 1988 and June 1993 and 502 controls in 66 counties of eastern Nebraska, USA. The dietary assessment included several questions about usual cooking methods for meats and doneness preference for beef. High intake of red meat was associated with increased risks for stomach and oesophageal cancers. Overall, broiling or frying of beef, chicken or pork was not associated with the risk of these tumours. Barbecuing/grilling, reported as the usual cooking method for a small number of study participants, was associated with an elevated risk of stomach and oesophageal cancers. After excluding those who reported usually barbecuing/grilling, a source of polycyclic aromatic hydrocarbons and heterocyclic amines (HCA), doneness level was evaluated as a surrogate for HCA exposure. Compared to a preference for rare/medium rare beef, odds ratios were 2.4 for medium, 2.4 for medium well and 3.2 for well done, a significant positive trend. Doneness level was not associated with a significant trend in risk of oesophageal cancer. KW - amines KW - beef KW - chicken meat KW - consumption KW - cooking KW - digestive tract KW - frying KW - heterocyclic nitrogen compounds KW - neoplasms KW - oesophagus KW - pigmeat KW - polycyclic hydrocarbons KW - poultry KW - stomach KW - Nebraska KW - USA KW - fowls KW - man KW - Gallus gallus KW - Gallus KW - Phasianidae KW - Galliformes KW - birds KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Northern Plains States of USA KW - West North Central States of USA KW - North Central States of USA KW - cancers KW - chickens KW - domesticated birds KW - esophagus KW - gastrointestinal tract KW - pork KW - United States of America KW - Meat Produce (QQ030) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403739&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. AU - Tabernero, C. AU - Zolotukhin, A. S. AU - Bear, J. AU - Schneider, R. AU - Karsenty, G. AU - Felber, B. K. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 1 SP - 95 EP - 101 SN - 0022-538X AD - Tabernero, C.: Human Retrovirus Pathogenesis Group, National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972001537. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 63231-63-0. N2 - HIV-1 replication depends on the posttranscriptional regulation by the viral Rev protein and can be replaced with the posttranscriptional RNA control element (CTE) of the type D simian retroviruses. It identifies a sequence which shares only nucleotide sequences of the internal loops and secondary structure with the CTE and which is part of the novel murine intracisternal-A particle (IAP) retroelement, inserted within the transcribed mouse osteocalcin-related gene. This sequence, named CTEIAP, can replace the Rev-mediated regulation of HIV-1, hence it is a posttranscriptional regulatory element. Related elements have been identified in other IAPs. These results suggest that insertional mutagenesis can affect gene expression by providing a functional posttranscriptional control element. The CTEIAP and CTEs of the type D simian retroviruses represent a novel class of RNA elements characterized by unique sequences within the internal loops which are predicted to represent the interaction site with cellular factor(s). These findings suggest that such elements may be involved in posttranscriptional regulation of cellular mRNAs. KW - gene expression KW - human immunodeficiency viruses KW - identification KW - interactions KW - microbiology KW - nucleotide sequences KW - nucleotides KW - regulation KW - regulatory genes KW - replication KW - rev gene KW - rna KW - shares KW - structure KW - unique sequences KW - Human immunodeficiency virus 1 KW - mice KW - monkeys KW - Retroviridae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Primates KW - DNA sequences KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - unique DNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001537&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Control of immunodeficiency and lymphoproliferation in mouse AIDS: studies of mice deficient in CD8+ T cells or perforin. AU - Tang Yao AU - Hügin, A. W. AU - Giese, N. A. AU - Gabrielle, L. AU - Chattopadhyay, S. K. AU - Fredrickson, T. N. AU - Kägi, D. AU - Hartley, J. W. AU - Morse, H. C. III JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 3 SP - 1808 EP - 1813 SN - 0022-538X AD - Tang Yao: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, 9000 Rockville Pike, Bethesda, MD 20892-0760, USA. N1 - Accession Number: 19972003129. Publication Type: Journal Article. Language: English. N2 - CD8+ T cells were previously shown to be important in preventing lymphoproliferation and immunodeficiency following infection of murine AIDS (MAIDS)-resistant mice with LP-BM5 mixture of murine leukaemia viruses. To evaluate further the mechanisms contributing to MAIDS resistance, the authors studied mice lacking CD8+ T cells or deficient in perforin owing to knockout of the β2-microglobulin (β2M) or perforin gene, respectively. In contrast to wild-type, MAIDS-resistant controls, , B10.A mice homozygous for the β2M mutation and B10.D2 mice homozygous for the perforin mutation were diagnosed as having MAIDS by five to eight weeks after infection by the criteria of lymphoproliferation, impaired proliferative responses to mitogens, and changes in cell population as judged by histopathology and flow cytometry. Unexpectedly, there was no progression of lymphoproliferation through 24 weeks, even though immune functions were severely compromised. Expression of the defective virus responsible for MAIDS was enhanced in spleens of the knockouts in comparison with wild-type mice. These results demonstrate that perforin-dependent functions of CD8+ T cells contribute to MAIDS resistance but that other, non-CD8+-dependent mechanisms are of equal or greater importance. KW - acquired immune deficiency syndrome KW - animal models KW - CD8+ lymphocytes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - immunopathology KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD8+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003129&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable. AU - Sinclair, E. AU - Barbosa, P. AU - Feinberg, M. B. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 5 SP - 3641 EP - 3651 SN - 0022-538X AD - Sinclair, E.: Office of AIDS Research, National Institutes of Health, 31 Center Dr., Building 31, Room 4C06, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004681. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - To establish more clearly whether the SIV and HIV-1 nef gene products are functionally analogous, the replication kinetics and infectivity of variants of SIVmac329 that either do (SIVnef+) or do not (SIVΔnef) encode intact nef gene products were compared. SIVnef+ replicates more rapidly than nef-defective viruses in both humans and rhesus peripheral blood mononuclear cells. As previously described for HIV-1 Nef, SIV Nef also enhances virus infectivity within each cycle of virus replication. As a strategy for evaluating the in vivo contribution of HIV-1 nef alleles and long terminal repeat regulatory sequences to the pathogenesis of immunodeficiency disease, SIV-HIV chimeras were constructed, in which the nef coding and U3 regulator regions of SIVmac329 were replaced by the corresponding regions from HIV-1/R73 (SIVR7nef+). SIVR7nef+ displays enhanced infectivity and accelerated replication kinetics in primary human and rhesus PBMC infections compared to its nef-defective counterpart. Converse chimeras, containing SIV Nef in an HIV-1 background (R7SIVnef+) also exhibit greater infectivity than matched nef-defective viruses (R7SIVΔnef). These data indicate that SIV Nef, like that of HIV-1, does enhance virus replication in primary cells in tissue culture and that HIV-1 and SIV Nef are functionally interchangeable in the context of both HIV-1 and SIV. KW - chimaeras KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - infections KW - infectivity KW - kinetics KW - microbiology KW - nef gene KW - Nef protein KW - regulatory genes KW - replication KW - tissue culture KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - monkeys KW - simian immunodeficiency virus KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chimeras KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004681&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques. AU - Digilio, L. AU - Giri, A. AU - Cho, N. AU - Slattery, J. AU - Markham, P. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 5 SP - 3684 EP - 3692 SN - 0022-538X AD - Digilio, L.: Laboratory of Basic Research, National Cancer Institute, NIH, 37 Convent Dr., MSC 4255 Bldg. 37, Room 6A11, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972004682. Publication Type: Journal Article. Language: English. Number of References: 60 ref. N2 - STLV-2pan-p is a novel retrovirus distantly related to HTLV-II and displays a host range similar to that demonstrated for other HTLV and STLV strains. KW - hosts KW - HTLV infections KW - human diseases KW - microbiology KW - pathogenesis KW - phylogenetics KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Macaca KW - monkeys KW - Pan KW - Pan paniscus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Deltaretrovirus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pongidae KW - Pan KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - other Retroviridae KW - simian T-cell lymphotropic virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells. AU - Robertson, S. J. AU - Hasenkrug, K. J. AU - Chesebro, B. AU - Portis, J. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 7 SP - 5287 EP - 5294 SN - 0022-538X AD - Robertson, S. J.: Correspondence address [Portis, J. L.]: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S. 4th St., Hamilton, MT 59840, USA. N1 - Accession Number: 19972006022. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - Properties of the CNS infection by 2 of the neurovirulent viruses, Fr98 and Fr98/SE, and the non-neurovirulent virus Fr54 were examined in detail in an effort to identify features of these infections that correlate with neurovirulence. No differences were found between the neurovirulent and non-neurovirulent viruses with respect to the appearance of vacuolar degeneration, activation of astrocytes and microglial cells, regional distribution of virus, or the cell types infected in the brain. However, application of more quantitative measurements of viral protein expression in the brain revealed viral burden to be a consistent correlate of neurovirulence in this model. It is suggested that the neurovirulent viruses differ from the non-neurovirulent virus in the extent of their spread among microglial cells after initial virus entry into the brain. KW - brain KW - central nervous system KW - infection KW - infections KW - microbiology KW - neuroglia KW - pathogenesis KW - pathogenicity KW - properties KW - viral proteins KW - mice KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - CNS KW - glial cells KW - other Retroviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006022&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo. AU - Fujisawa, R. AU - McAtee, F. J. AU - Zirbel, J. H. AU - Portis, J. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 7 SP - 5355 EP - 5360 SN - 0022-538X AD - Fujisawa, R.: Correspondence address [Portis, J. L.]: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S. 4th St., Hamilton, MT 59840, USA. N1 - Accession Number: 19972006023. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - The processing of the protein expressed in fibroblasts was compared with that expressed in the spleens of infected mice. Expression of the glycosylated Gag precursor as well as its proteolytic cleavage appeared similar in vitro and in vivo, although differences in glycosylation were noted. However, whereas the L domain exhibited strictly a cytosolic orientation in fibroblasts in vitro, it was displayed at the cell surface on a subpopulation of spleen cells in vivo, suggesting an alternate orientation in the membrane. KW - experimental infections KW - fibroblasts KW - gag protein KW - in vitro KW - microbiology KW - precursors KW - proteolysis KW - spleen KW - structural genes KW - virulence KW - mice KW - Murine leukemia virus KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - murine leukaemia virus KW - other Retroviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006023&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. AU - Zhang YiMing AU - Imamichi, H. AU - Imamichi, T. AU - Lane, H. C. AU - Falloon, J. AU - Vasudevachari, M. B. AU - Salzman, N. P. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 9 SP - 6662 EP - 6670 SN - 0022-538X AD - Zhang YiMing: Correspondence address [Salzman, N. P.]: SAIC Frederick, Frederick Cancer Research & Development Center, National Cancer Institute, Frederick, MD, USA. N1 - Accession Number: 19972008513. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 150378-17-9, 63231-63-0. N2 - Two different responses to the therapy were observed in a group of patients receiving the protease inhibitor indinavir. In one, suppression of virus replication occurred and has persisted for 90 weeks (bDNA, <500 HIV-l RNA copies/ml). In the second group, a rebound in virus levels in plasma followed the initial sharp decline observed at the start of therapy. This was associated with the emergence of drug-resistant variants. Sequence analysis of the protease gene during the course of therapy revealed that in this second group there was a sequential acquisition of protease mutations at amino acids 46, 82, 54, 71, 89, and 90. In the six patients in this group, there was also an identical mutation in the gag p7/pl gag protease cleavage site. In three of the patients, this change was seen as early as 6 to 10 weeks after the start of therapy. In one patient, a second mutation occurred at the gag pl/p6 cleavage site, but it appeared 18 weeks after the time of appearance of the p7/pl mutation. Recombinant HIV-1 variants containing two or three mutations in the protease gene were constructed either with mutations at the p7/pl cleavage site or with wild-type (WT) gag sequences. When recombinant HIV-I-containing protease mutations at 46 and 82 was grown in MT2 cells, there was a 68% reduction in its rate of replication compared to the WT virus. Introduction of an additional mutation at the gag p7/pl protease cleavage site compensated for the partially defective protease gene. Similarly, rates of replication of viruses with mutations M46L/I, I54V, and V82A in protease were enhanced both in the presence and in the absence of Indinavir when combined with mutations in the gag p7/pl and the gag pl/p6 cleavage sites. Optimal rates of virus replication require protease cleavage of precursor polyproteins. A mutation in the cleavage site that enhanced the availability of a protein that was rate limiting for virus maturation would confer on that virus a significant growth advantage and may explain the uniform emergence of viruses with alterations at the p7/pl cleavage site. This is the first report of the emergence of mutations in the gag p7/pl protease cleavage sites in patients receiving protease therapy and identifies this change as an important determinant of HIV-l resistance to protease inhibitors in patient populations. KW - amino acids KW - antiviral agents KW - blood plasma KW - drug resistance KW - drug therapy KW - gag gene KW - gag protein KW - indinavir KW - inhibitors KW - mutations KW - precursors KW - proteinase inhibitors KW - proteinases KW - replication KW - RNA KW - treatment KW - viral replication KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antiretrovirals KW - chemotherapy KW - cleavage sites KW - human immunodeficiency virus type 1 KW - plasma (blood) KW - protease gene KW - protease inhibitors KW - proteases KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008513&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes. AU - Lebedeva, I. AU - Fujita, K. AU - Nihrane, A. AU - Silver, J. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 9 SP - 7061 EP - 7067 SN - 0022-538X AD - Lebedeva, I.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980500374. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Semliki Forest virus vectors encoding murine leukaemia virus (MLV) envelope protein with a truncated cytoplasmic tail generate submicrometre, cell-associated, membranous particles which transmit replication-competent vector RNA specifically to cells bearing the MLV receptor. Such "minimal" viruses could have applications as retroviral vaccines or in the study of virus evolution. KW - arboviruses KW - disease vectors KW - envelope proteins KW - gene expression KW - infections KW - molecular genetics KW - vectors KW - viral proteins KW - murine leukemia virus KW - Semliki Forest virus KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Alphavirus KW - Togaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - arthropod-borne viruses KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection. AU - Nowak, M. A. AU - Lloyd, A. L. AU - Vasquez, G. M. AU - Wiltrout, T. A. AU - Wahl, L. M. AU - Bischofberger, N. AU - Williams, J. AU - Kinter, A. AU - Fauci, A. S. AU - Hirsch, V. M. AU - Lifson, J. D. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 10 SP - 7518 EP - 7525 SN - 0022-538X AD - Nowak, M. A.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Building 535, Room 509, Frederick, MD 21702, USA. N1 - Accession Number: 19972010765. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 63231-63-0. N2 - Mathematical modelling of viral replication dynamics, based on sequential measurements of levels of virion-associated RNA in plasma during antiretroviral treatment, has led to fundamental new insights into HIV-1 pathogenesis. The SIV-infected macaque model was used to perform detailed measurements and mathematical modelling during primary infection and during treatment of established infection with the antiretroviral drug (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA). The calculated clearance half-life for productively infected cells during resolution of the peak viraemia of primary infection was of the order of 1 day, with slightly shorter clearance half-lives calculated during PMPA treatment. Viral reproduction rates upon discontinuation of PMPA treatment after 2 weeks were approximately twofold greater than those obtained just prior to initiation of treatment in the same animals, likely reflecting accumulation of susceptible target cells during treatment. The basic reproductive ratio (R0) for the spread of SIV infection in vivo, which represents the number of productively infected cells derived from each productively infected cell at the beginning of infection, was also estimated. This parameter quantifies the extent to which antiviral therapy or vaccination must limit the initial spread of virus to prevent establishment of chronic disseminated infection. The results thus provide an important guide for efforts to develop vaccines against SIV and, by extension, HIV. KW - animal models KW - antiviral agents KW - blood plasma KW - chronic course KW - disseminated infections KW - drug therapy KW - dynamics KW - half life KW - human diseases KW - human immunodeficiency viruses KW - infection KW - mathematical models KW - models KW - replication KW - reproduction KW - RNA KW - therapy KW - treatment KW - vaccination KW - vaccines KW - viral replication KW - Macaca KW - monkeys KW - simian immunodeficiency virus KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - plasma (blood) KW - primary infections KW - ribonucleic acid KW - therapeutics KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010765&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge. AU - Buge, S. L. AU - Alipanah, S. AU - Markham, A. P. AU - Cheng, S. AU - Kalyan, N. AU - Miller, C. J. AU - Lubeck, M. AU - Udem, S. AU - Eldridge, J. AU - Robert-Guroff, M. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 11 SP - 8531 EP - 8541 SN - 0022-538X AD - Buge, S. L.: Basic Research Laboratory, National Cancer Institute, Building 37, Room 6A11, 37 Convent Dr., Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19972010798. Publication Type: Journal Article. Language: English. Number of References: 59 ref. N2 - This study establishes that the rhesus macaque model is suitable for assessing adenovirus (Ad)-based SIV vaccines. Using a combination protocol involving (i) priming with an Ad5 host range mutant (Ad5hr)-SIVsmenv recombinant that efficiently replicates in monkey cells and expresses the SIVsm envelope gene and (ii) boosting with a native subunit, SIVmac251 gp120, it is demonstrated that humoral, cellular, and mucosal immune responses are elicited in rhesus macaques. It is further shown that this approach, in which only SIV envelope was used as immunogen, resulted in significantly decreased viral burdens following infection with the virulent SIVmac251 isolate by the vaginal route. Inclusion of additional SIV components in the vaccine should result in greater protective efficacy. The availability of this new rhesus macaque model will expedite evaluation of additional Ad recombinants in this highly promising combination vaccine approach and will facilitate testing of protective efficacy of the Ad-based vaccine strategy against multiple routes of viral transmission. KW - ENV gene KW - HIV infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - infection KW - mucosa KW - responses KW - vaccines KW - vagina KW - virulence KW - Macaca KW - Macaca mulatta KW - monkeys KW - simian immunodeficiency virus KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Macaca KW - HUMAN IMMUNODEFICIENCY VIRUS KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - mucous membrane KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010798&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice. AU - Lavignon, M. AU - Richardson, J. AU - Evans, L. H. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 11 SP - 8923 EP - 8927 SN - 0022-538X AD - Lavignon, M.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19972010809. Publication Type: Journal Article. Language: English. Number of References: 48 ref. N2 - These studies identified a region of the MuLv genome which encodes the nucleocapsid protein and a portion of the viral protease as the only region that influenced the difference in polytropic-MuLV generation by Mo-MuLV and F-MuLV57. KW - genomes KW - monoclonal antibodies KW - nucleocapsid proteins KW - proteinases KW - Murine leukemia virus KW - Retroviridae KW - viruses KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - murine leukaemia virus KW - proteases KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010809&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. AU - Lifson, J. D. AU - Nowak, M. A. AU - Goldstein, S. AU - Rossio, J. L. AU - Kinter, A. AU - Vasquez, G. AU - Wiltrout, T. A. AU - Brown, C. AU - Schneider, D. AU - Wahl, L. AU - Lloyd, A. L. AU - Williams, J. AU - Elkins, W. R. AU - Fauci, A. S. AU - Hirsch, V. M. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 12 SP - 9508 EP - 9514 SN - 0022-538X AD - Lifson, J. D.: Laboratory of Retroviral Pathogenesis, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute-Frederick Cancer Resarch and Development Center, Bldg 535, Rm 509, Frederick, MD 21702. N1 - Accession Number: 19982000527. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Registry Number: 63231-63-0. N2 - Different patterns of viral replication correlate with the natural history of disease progression in humans and macaques infected with HIV-1 and SIV, respectively. However, the viral and host factors influencing these patterns of viral replication in vivo are poorly understood. We intensively studied viral replication in macaques receiving identical inocula of SIV. Marked differences in viral replication patterns were apparent within the first week following inoculation, a time prior to the development of measurable specific immune effector responses to viral antigens. Plasma viral RNA levels measured on day 7 postinoculation correlated with levels measured in the postacute phase of infection. Differences in the susceptibility of host cells from different animals to in vitro SIV infection correlated with the permissiveness of the animals for early in vivo viral replication and hence with the postacute set point level of plasma viremia. These results suggest that host factors that exert their effects prior to full development of specific immune responses are critical in establishing the in vivo viral replication pattern and associated clinical course in subjects infected with SIV and, by extension, with HIV-1. KW - blood plasma KW - clinical aspects KW - disease course KW - HIV-1 infections KW - hosts KW - human diseases KW - immune response KW - in vitro KW - infection KW - pathogenesis KW - replication KW - responses KW - RNA KW - susceptibility KW - viral replication KW - Human immunodeficiency virus 1 KW - Macaca KW - man KW - monkeys KW - simian immunodeficiency virus KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - clinical picture KW - disease progression KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - plasma (blood) KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000527&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1. AU - Moriuchi, H. AU - Moriuchi, M. AU - Arthos, J. AU - Hoxie, J. AU - Fauci, A. S. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 12 SP - 9664 EP - 9671 SN - 0022-538X AD - Moriuchi, H.: National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Dr., MSC-1576, Bethesda, MD 20892-1576. N1 - Accession Number: 19982000531. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - Different strains of HIV-1 vary markedly in the ability to infect cells of the monocyte/macrophage (M/M) lineage. M/M are generally resistant to infection with T-cell-tropic (T-tropic) strains of HIV-1. Recently, the chemokine receptors CCR5 and CXCR4 were identified as cofactors for fusion/entry of macrophage- and T-tropic strains of HIV-1, respectively. To investigate the mechanisms of resistance of M/M to T-tropic HIV-1 infection, a number of subclones of the U937 pro-monocytic cell line were examined. It was found that certain subclones of U937 (plus clones) could, while others (minus clones) could not, support replication of T-tropic strains of HIV-1. It was demonstrated that (i) both minus and plus clones support HIV-1 replication when transfected with an infectious molecular cDNA clone of a T-tropic HIV-1; (ii) minus clones do not, but plus clones do, efficiently support fusion with cells expressing HIV-1 IIIB Env; (iii) both plus and minus clones (with the exception of one clone) express physiologically functional CXCR4 protein as well as CD4 on the cell surface; (iv) introduction of CXCR4 into the CXCR4-negative clone does not restore fusogenicity with or susceptibility to T-tropic HIV-1; and (v) a ligand (stromal cell-derived factor 1) for or a monoclonal antibody (12G5) to CXCR4 does not effectively inhibit HIV-mediated cell-to-cell fusion of U937 cells. These data indicate that resistance to T-tropic HIV-1 infection of U937 minus clones occurs at fusion/ entry events and that expression of functional CXCR4 and CD4 is not a sole determinant for susceptibility to T-tropic HIV-1 infection; furthermore, they suggest that other factors are positively or negatively involved in HIV-mediated cell-to-cell fusion in U937 pro-monocytic cells. KW - antibodies KW - CD4 antigens KW - chemokines KW - clones KW - cofactors KW - complementary DNA KW - cytokines KW - human diseases KW - human immunodeficiency viruses KW - infection KW - monoclonal antibodies KW - pathogenesis KW - receptors KW - replication KW - resistance KW - strains KW - susceptibility KW - tropisms KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - cDNA KW - cloning KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000531&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficient expression by an alphavirus replicon of a functional ribozyme targeted to human immunodeficiency virus type 1. AU - Smith, S. M. AU - Maldarelli, F. AU - Jeang KuanTeh JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 12 SP - 9713 EP - 9721 SN - 0022-538X AD - Smith, S. M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bulding 4, Room 306, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19980500200. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 63231-63-0. N2 - Intracellular applications of ribozymes have been limited partly by the availability of suitable high-expression systems. For RNA effectors, consideration of an RNA virus vector system for delivery and expression is reasonable. It is shown that alphavirus replicons can be highly efficient non-integrating ribozyme-expressing vectors. Using a hammerhead ribozyme targeted to a highly conserved sequence in the U5 region of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, it was demonstrated that a full-length 8.3-kb Semliki Forest virus ribozyme (SFVRz) chimeric RNA maintains catalytic activity. SFVRz is packaged into viral particles, and these particles transduce mammalian cells efficiently. SFVRz-transduced BHK cells were found to produce large amounts of genomic and subgenomic forms of ribozyme-containing RNAs that are functional in cleaving a U5-tagged mRNA. The RNase protection assay shows that HIV-1 U5-chloramphenicol acetyltransferase mRNA expressed intracellularly from an RNA polymerase II promoter is quantitatively eliminated in SFVRz-transduced BHK cells. KW - antiviral agents KW - enzymes KW - gene expression KW - human diseases KW - human immunodeficiency viruses KW - RNA KW - Alphavirus KW - Semliki Forest virus KW - Togaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Alphavirus KW - human immunodeficiency virus KW - ribonucleic acid KW - ribozymes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500200&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. AU - Kolenitchenko, V. AU - King, L. AU - Riva, A. AU - Tani, Y. AU - Korsmeyer, S. J. AU - Cohen, D. I. JO - Journal of Virology JF - Journal of Virology Y1 - 1997/// VL - 71 IS - 12 SP - 9753 EP - 9763 SN - 0022-538X AD - Kolenitchenko, V.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm. 6A11, Bethesda, MD 20892-4255. N1 - Accession Number: 19982000534. Publication Type: Journal Article. Language: English. Number of References: 85 ref. N2 - The relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1) was investigated, by employing diverse strategies to inhibit PCD or to detect its common end-stage sequelae. When Bcl-2-transfected cell lines were infected with HIV-l, their viability was only slightly higher than that of control infections. Although the adenovirus ElB 19-kDa protein has been reported to be a stronger competitor of apoptosis than Bcl-2, it did not inhibit HIV-mediated cell death better than Bcl-2 protein. Competition for Fas ligand or inactivation of the Fas pathway secondary to intracellular mutation (MOLT-4 T cells) also had modest effects on overall cell death during acute HIV infection. In contrast to these observations with HIV infection or with HIV envelope-initiated cell death, Tat-expressing cell lines were much more susceptible (200% enhancement) to Fas-induced apoptosis than controls and Bcl-2 overexpression strongly (75%) inhibited this apoptotic T-cell death. PCD associated with FasR ligation resulted in the cleavage of common interleukin-1β converting enzyme (ICE)-protease targets, poly(ADP-ribose) polymerase (PARP) and pro-ICE, whereas cleaved products were not readily detected during HIV infection of peripheral blood mononuclear cells or T-cell lines even during periods of extensive cell death. These results indicate that one important form of HIV-mediated cell killing proceeds by a pathway that lacks the characteristics of T-cell apoptosis. The authors' observations support the conclusion that at least 2 HIV genes (env and tat) can kill T cells by distinct pathways and that an envelope-initiated process of T-cell death can be discriminated from apoptosis by many of the properties most closely associated with apoptotic cell death. KW - acute infections KW - apoptosis KW - cell lines KW - death KW - genes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - inactivation KW - infection KW - ligature KW - mutations KW - properties KW - T lymphocytes KW - Adenoviridae KW - human adenovirus KW - Human immunodeficiency virus 1 KW - viruses KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Mastadenovirus KW - Adenoviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - ligation KW - mononuclear cells KW - peripheral blood KW - severe infections KW - strategies KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current status of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccine development: memorandum from a joint WHO/NIAID meeting. AU - Murphy, B. R. AU - Collins, P. L. JO - Bulletin of the World Health Organization JF - Bulletin of the World Health Organization Y1 - 1997/// VL - 75 IS - 4 SP - 307 EP - 313 SN - 0042-9686 AD - Murphy, B. R.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. N1 - Accession Number: 19982006620. Publication Type: Journal Article. Language: English. Language of Summary: French. Subject Subsets: Public Health N2 - A summary of a joint WHO/NIAID meeting on the current status of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccine development, held in Bethesda, Maryland, USA, 30 September-October 1996, is presented. The worldwide impact of RSV and PIV3, current status of development of RSV and PIV3 vaccines, applications of recombinant DNA technology to the development and characterization of vaccines and to the understanding of viral pathogenesis, are discussed. KW - disease prevention KW - human diseases KW - parainfluenza viruses KW - reviews KW - vaccine development KW - vaccines KW - viral diseases KW - human respiratory syncytial virus KW - man KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Paramyxovirinae KW - parainfluenza virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006620&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors. AU - Fujita, K. AU - Omura, S. AU - Silver, J. JO - Journal of General Virology JF - Journal of General Virology Y1 - 1997/// VL - 78 IS - 3 SP - 619 EP - 625 SN - 0022-1317 AD - Fujita, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004274. Publication Type: Journal Article. Language: English. Number of References: 23 ref. N2 - HIV-1 encodes 3 genes, Vpu, Env and Nef, that decrease cellular CD4. Vpu and Env act cooperatively to accelerate degradation of CD4 in the endoplasmic reticulum. It is reported that Vpu/Env-induced CD4 degradation is inhibited by lactacystin, a specific inhibitor of the proteasome, and by other proteasome inhibitors, but not by non-proteasome protease inhibitors. It is also noted that Vpu has amino acid sequence homology with a segment of IκB known to be involved in proteasome-mediated degradation, suggesting that HIV-1 could have transduced cellular sequences to enhance down-regulation of CD4. KW - amino acid sequences KW - antiviral agents KW - cd4 antigens KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - inhibitors KW - microbiology KW - proteinase inhibitors KW - proteinases KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - CD4 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - protease inhibitors KW - proteases KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004274&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence variations and viral genomic state of human papillomavirus type 16 in penile carcinomas from Ugandan patients. AU - Tornesello, M. L. AU - Buonaguro, F. M. AU - Meglio, A. AU - Buonaguro, L. AU - Beth-Giraldo, E. AU - Giraldo, G. JO - Journal of General Virology JF - Journal of General Virology Y1 - 1997/// VL - 78 IS - 9 SP - 2199 EP - 2208 SN - 0022-1317 AD - Tornesello, M. L.: Division of Viral Oncology, National Cancer Institute, 'Fondazione Pascale', I-80131 Naples, Italy. N1 - Accession Number: 19982004686. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - Sequence variations in the E6/E7 (nt 34-880) and the L1 (nt 6584-7035) ORFs, and in the long control region (LCR) (nt 7289-93) of human papillomavirus type 16 (HPV-16) were analysed in five penile carcinoma biopsies obtained from Ugandan patients in 1972-80. Uganda is a country with a high incidence of genital cancers. All five isolates were classified as members of African-1 lineage (Af1) by phylogenetic analysis based on long control region (LCR) sequences. The E6 gene phylogenetic analysis, however, showed that four isolates fell into a new subclass designated Af1-u. This subclass, characterized by three point mutations located at the 5′ end of the E6 gene with resulting changes in amino acids at positions 10 and 14, is distinguishable from the Af1 class by the absence of synonymous mutations at nt 286 and 289. The nonsynonymous substitution at nt 335 was present in three out of five samples. The E6 Af1 mutation pattern was present in only a single Ugandan HPV-16 isolate. Nucleotide sequence analysis of the E7 and L1 regions did not allow any Af1 subclass identification. The physical state of the viral DNA in these samples was characterized by polymerase chain reaction (PCR) and Southern blot analysis. Oligonucleotides which enable amplification of the full length E2 region (nt 2734-3872) failed to amplify the target sequence in four out of five samples, suggesting disruption of the E2 ORF and integration of the HPV genome into the human DNA. Southern blot analysis confirmed the virus integration status. KW - carcinoma KW - DNA sequencing KW - neoplasms KW - nucleotide sequences KW - open reading frames KW - polymerase chain reaction KW - southern blotting KW - human papillomaviruses KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Papillomaviridae KW - cancers KW - DNA sequences KW - human papillomavirus KW - nucleotide sequence analysis KW - nucleotide sequencing KW - ORFs KW - Papovaviridae KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004686&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Syncytium formation induced by human immunodeficiency virus type 1 isolates correlates with affinity for CD4. AU - Watkins, B. A. AU - Crowley, R. AU - Davis, A. E. AU - Louie, A. T. AU - Reitz, M. S. Jr. JO - Journal of General Virology JF - Journal of General Virology Y1 - 1997/// VL - 78 IS - 10 SP - 2513 EP - 2522 SN - 0022-1317 AD - Watkins, B. A.: Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Correspondence address [Watkins, B. A.]: Matritech, Inc., 330 Nevada St, Newton, MA 02160, USA. N1 - Accession Number: 19982000344. Publication Type: Journal Article. Language: English. Number of References: 47 ref. N2 - This study investigated the contributions of different regions of the env gene to syncytia induction using chimeric viruses that contain part of the genome of a strain that lacks this ability (HIV-1Ba-L) within the genome of a virus that can form syncytia (HIV-1HXB-2). When tested in two cell lines susceptible to both parental viruses, as well as in primary cells, these chimeric viruses demonstrated that the ability to induce syncytia formation was determined by regions of env outside the V3 loop, which encompass residues that contribute to the binding of CD4 by gp120. Further investigation failed to show any difference in the expression of gp120 on the cell surface or cell adhesion molecules by cells infected with SI or NSI variants that would explain the observed differences in the ability to form syncytia. Assays of relative affinity for CD4 indicated that gp 120 from SI variants showed a significantly higher affinity for CD4 than gp 120 from NSI variants. These observations suggest that areas of the HIV-1 env gene contributing to the CD4 binding site may also contribute to the determination of syncytium-inducing (SI) and non-syncytium-inducing (NSI) phenotypes. KW - adhesion KW - binding KW - CD4 antigens KW - cell lines KW - cells KW - clinical aspects KW - ENV gene KW - envelope protein gp120 KW - formation KW - genomes KW - human immunodeficiency viruses KW - pathogenesis KW - phenotypes KW - prognosis KW - proteins KW - strains KW - surface proteins KW - syncytia KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - clinical picture KW - gp120 KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - membrane proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000344&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differences in corticotropin-releasing hormone-stimuated adrenocorticotropin and cortisol before and after weight loss. AU - Yanovski, J. A. AU - Yanovski, S. Z. AU - Gold, P. W. AU - Chrousos, G. P. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1997/// VL - 82 IS - 6 SP - 1874 EP - 1878 SN - 0021-972X AD - Yanovski, J. A.: National Institutes of Health, Building 10, Room 10N62-1862, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19971409410. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 6000-74-4, 125-04-2, 13609-67-1, 9015-71-8, 50-03-3, 50-23-7. Subject Subsets: Human Nutrition N2 - The hypothalamic-pituitary-adrenal (HPA) axis of 34 healthy obese women (35.9±7.3 years old; body mass index, 40.2±7.9 kg/m²) was studied before and after a 21.0±7.9-kg weight loss induced by a 26-week weight loss programme that included 12 weeks of a 3350 kJ/day (800 kcal/day) liquid formula diet, 6 weeks of gradual refeeding and 6 weeks of energy stabilization at 5020-6280 kJ/day (1200-1500 kcal/day). Obese subjects were evaluated twice: before energy restriction and during the last 3 weeks of energy stabilization with a 3-h evening 1 µg/kg ovine corticotrophin-releasing-hormone (oCRH) stimulation test. CRH-stimulated ACTH and cortisol values were compared to those of a control group of 12 normal weight women (33.9±6.6 years old). Before energy restriction, ACTH and cortisol responses to oCRH were similar in obese women and normal weight controls. Weight loss did not significantly alter the ACTH response to oCRH; however, the total plasma cortisol response to oCRH decreased with weight loss (area under the curve, 96 320±21 040 nmol/litre-1 min-1 before weight loss; 82 450±22 460 nmol/litre-1 min-1 after weight loss; P<0.001). Cortisol-binding globulin also decreased after weight loss (2 270±1 050) compared to values obtained before weight loss (3 590±1 360; P<0.001) or to those of normal weight controls (3 910±1 400 nmol/litre; P<0.001). Assay for plasma free cortisol, before or 180 min after oCRH treatment, showed no significant changes in cortisol responses resulting from weight loss. As plasma free cortisol was not altered by weight reduction, the decrease in the total cortisol response to oCRH after weight loss appears to be secondary to significant decreases in cortisol-binding globulin. It is concluded that when obese women lose large amounts of weight with a 3350 kJ/day, very low energy diet, such weight reduction does not significantly affect the HPA axis. KW - binding proteins KW - corticoliberin KW - hydrocortisone KW - obesity KW - weight reduction KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - corticotropin releasing factor KW - corticotropin releasing hormone KW - cortisol KW - fatness KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971409410&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction. AU - Lane, M. A. AU - Ingram, D. K. AU - Ball, S. S. AU - Roth, G. S. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1997/// VL - 82 IS - 7 SP - 2093 EP - 2096 SN - 0021-972X AD - Lane, M. A.: Gerontology Research Center, Nathan W. Shock Laboratories, National Institute on Aging, National Institutes of Health, Johns Hopkins University Bayview Campus, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19971411380. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 53-43-0, 14808-79-8. Subject Subsets: Human Nutrition N2 - Male and female rhesus monkeys exhibited a steady, age-related decline in serum dehydroepiandrosterone [prasterone] sulfate (DHEAS). This decline met several criteria for a biomarker of aging, including cross-sectional and longitudinal linear decreases with age and significant stability of individual differences over time. In addition, the proportional age-related loss of DHEAS in rhesus monkeys was over twice the rate of decline observed in man. Most important was the finding that, in rhesus monkeys, energy restriction (70% of ad libitum intake), which extends life span and retards aging in laboratory rodents, slowed the postmaturational decline in serum DHEAS levels. This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species. KW - aging KW - food restriction KW - markers KW - prasterone KW - sulfate KW - monkeys KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - dehydroepiandrosterone KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411380&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin 1α increases serum leptin concentrations in humans. AU - Janik, J. E. AU - Curti, B. D. AU - Considine, R. V. AU - Rager, H. C. AU - Powers, G. C. AU - Alvord, W. G. AU - Smith, J. W., II AU - Gause, B. L. AU - Kopp, W. C. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1997/// VL - 82 IS - 9 SP - 3084 EP - 3086 SN - 0021-972X AD - Janik, J. E.: Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, Maryland 20892-1906, USA. N1 - Accession Number: 19971412848. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 169494-85-3. Subject Subsets: Human Nutrition N2 - Serum leptin concentrations were measured in patients with cancer before and after administration of recombinant human interleukin (IL)-1α. 14 patients (8 men and 6 women aged 32-70 years) received IL-1α 0.03, 0.1 or 0.3 µg/kg daily for 5 days. Serum leptin concentrations increased in all but 2 patients within 24 h after the first dose. The increase in leptin was correlated directly with IL-1α dose (P=0.0030). Despite continued administration of IL-1α, serum leptin concentrations returned to pretreatment levels by day 5 of therapy. It is concluded that an increase in serum leptin concentrations may be 1 mechanism by which anorexia is induced by IL-1α. However, tachyphylaxis of the leptin response suggests that other mechanisms also are involved. KW - blood KW - cytokines KW - hormones KW - interleukin 1 KW - interleukins KW - leptin KW - neoplasms KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412848&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosoma mansoni: unisexual infections sensitize mice for granuloma formation around intravenously injected eggs. AU - Cheever, A. W. AU - Lewis, F. A. AU - Wynn, T. A. JO - Parasitology Research JF - Parasitology Research Y1 - 1997/// VL - 83 IS - 1 SP - 57 EP - 59 SN - 0044-3255 AD - Cheever, A. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970800902. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Helminthology N2 - Mice carrying unisexual infections with male or female Schistosoma mansoni for 9 weeks developed accelerated and augmented reactions to S. mansoni eggs injected iv. The size of circumoval granulomas observed in the lungs of unisexually infected mice did not differ significantly from the reactions seen in bisexually infected mice. Tissue eosinophilia in the granulomas was also augmented similarly over that in naive mice by unisexual or bisexual infection. The cross-reactivity between worm and egg antigens is considered relevant to the development of acute toxaemic schistosomiasis mansoni and, perhaps, to the consideration of antigens to be used for vaccination against S. mansoni infection. KW - experimental infections KW - helminths KW - human diseases KW - immunopathology KW - laboratory animals KW - ova KW - parasites KW - pathogenesis KW - schistosomiasis KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - granulomata KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800902&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparum: a high proportion of parasites from a population of the Dd2 strain are able to invade erythrocytes by an alternative pathway. AU - Soubes, S. C AU - Wellems, T. E. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1997/// VL - 86 IS - 1 SP - 79 EP - 83 SN - 0014-4894 AD - Soubes, S. C: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980803304. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9001-67-6. Subject Subsets: Protozoology N2 - Evidence is presented that a switch in gene expression from inability to ability to invade neuraminidase [sialidase]-treated erythrocytes has occurred in a high proportion of parasites in a population of the Plasmodium falciparum Dd2 clone. The high proportion of the Dd2-Nm (sialic acid-independent) subpopulation (1 of 217, 0.46%) argues for the existence of high frequency mutations, allowing the switch to an alternative pathway of invasion rather than the selection of low mutation events. KW - cell invasion KW - erythrocytes KW - gene expression KW - genetics KW - host parasite relationships KW - human diseases KW - malaria KW - mutations KW - parasites KW - sialidase KW - strains KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - blood red cells KW - exo-alpha-sialidase KW - neuraminidase KW - parasite host relationships KW - red blood cells KW - sialic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803304&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interaction between timing of perinatal human immunodeficiency virus infection and the design of preventive and therapeutic interventions. AU - Mofenson, L. M. JO - Acta Paediatrica, Supplement JF - Acta Paediatrica, Supplement Y1 - 1997/// VL - 86 IS - 421 SP - 1 EP - 9 CY - Stockholm; Sweden PB - Scandinavian University Press SN - 0803-5326 AD - Mofenson, L. M.: Pediatric, Adolescent & Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health & Human Development, National Institutes of Health, Rockville, MD, USA. N1 - Accession Number: 19972006612. Publication Type: Journal Article. Language: English. Registry Number: 30516-87-1. N2 - In 1994, the hypothesis that transmission of HIV from mother to child could be interrupted became a reality when it was shown that a regimen of zidovudine given to HIV-infected pregnant women and their newborn infants could reduce the risk of perinatal transmission by two-thirds. An understanding of the pathogenesis of transmission is crucial for interpreting these results, for design of future interventions and for understanding the natural history of perinatal HIV infection. This paper reviews current information regarding the timing of and risk factors for perinatal HIV transmission, and the relationship between the timing of transmission and design of efforts to interrupt transmission and to slow disease progression in infected infants. KW - antiviral agents KW - children KW - disease course KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - intervention KW - maternal transmission KW - mothers KW - neonates KW - pregnancy KW - prevention KW - prophylaxis KW - regimens KW - relationships KW - reviews KW - risk factors KW - transmission KW - women KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - chemotherapy KW - disease progression KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - newborn infants KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) KW - Women (UU500) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006612&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vertical transmission of human immunodeficiency virus type 1 : insights from studies of multiple pregnancies. AU - Goedert, J. J. JO - Acta Paediatrica, Supplement JF - Acta Paediatrica, Supplement Y1 - 1997/// VL - 86 IS - 421 SP - 56 EP - 59 CY - Stockholm; Sweden PB - Scandinavian University Press SN - 0803-5326 AD - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, Suite 434, Rockville, MD 20852, USA. N1 - Accession Number: 19972006706. Publication Type: Journal Article. Language: English. Number of References: 12 ref. KW - acquired immune deficiency syndrome KW - disease course KW - epidemiology KW - experiments KW - human diseases KW - human immunodeficiency viruses KW - immunogenetics KW - infection KW - maternal transmission KW - mothers KW - multiple births KW - pregnancy KW - registration KW - survival KW - susceptibility KW - transmission KW - Human immunodeficiency virus 1 KW - Lentivirus KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cloning KW - disease progression KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006706&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reducing the risk of perinatal HIV-1 transmission with zidovudine: results and implications of AIDS Clinical Trials Group protocol 076. AU - Mofenson, L. M. JO - Acta Paediatrica, Supplement JF - Acta Paediatrica, Supplement Y1 - 1997/// VL - 86 IS - 421 SP - 89 EP - 96 CY - Stockholm; Sweden PB - Scandinavian University Press SN - 0803-5326 AD - Mofenson, L. M.: Pediatric, Adolescent & Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health & Human Development, National Institutes of Health, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA. N1 - Accession Number: 19972006713. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 30516-87-1. KW - acquired immune deficiency syndrome KW - antiviral agents KW - clinical aspects KW - clinical trials KW - drug therapy KW - guidelines KW - human diseases KW - human immunodeficiency viruses KW - maternal transmission KW - mothers KW - prophylaxis KW - public health KW - transmission KW - treatment KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - recommendations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006713&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progress in prevention of perinatal HIV-1. AU - Fowler, M. G. AU - Mofenson, L. JO - Acta Paediatrica, Supplement JF - Acta Paediatrica, Supplement Y1 - 1997/// VL - 86 IS - 421 SP - 97 EP - 103 CY - Stockholm; Sweden PB - Scandinavian University Press SN - 0803-5326 AD - Fowler, M. G.: Efficacy Trials Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19972006714. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 30516-87-1. KW - antiviral agents KW - clinical aspects KW - clinical trials KW - disease prevention KW - disseminated infections KW - drug therapy KW - HIV-1 infections KW - human diseases KW - maternal transmission KW - mothers KW - neonates KW - prophylaxis KW - reviews KW - transmission KW - zidovudine KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AZT KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - newborn infants KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006714&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection. AU - Freed, E. O. AU - Englund, G. AU - Maldarelli, G. AU - Martin, M. A. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1997/// VL - 88 IS - 2 SP - 171 EP - 174 SN - 0092-8674 AD - Freed, E. O.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972003203. Publication Type: Journal Article. Language: English. N2 - The authors comment on studies by Gallay et al.(Cell, [1995] 80 379-388; 83 569-576). In reply, Trono and Gallay comment: Freed et al. previously questioned the role of matrix protein (MA) NLS in HIV-1 infection of macrophages. In line with this position, they now present data contesting the participation of the C-terminal phosphorylation of MA in this process. To address this controversy, Trono and Gallay first compared the status of MA tyrosine phosphorylation of their and Freed et al.'s viruses. Several points could be made. First, no significant difference was noted between their and Freed et al.'s viruses. Second, the phenotype of the Vpr/MA tyrosine mutant viruses systematically correlated with that of the Vpr/MA NLS variants. Third, the phenotype of both types of MA/Vpr-defective strains was linked to the multiplicity of infection (m.o.i.), so that these viruses exhibited wild-type replication kinetics when a high initial inoculum (i.e. 40 ng p24 antigen per 2 × 105 cells) was used, whereas their growth was severely impaired when the cells were exposed to a lower dose of virus (i.e. 0.2 or 2 ng p24 antigen per 2 × 105 cells), within the range of that used in all previous analyses. In summary, these results are consistent with the claim (see above references and Bukrinskaya et al. Proceedings of the National Academy of Sciences USA, [1996] 9 367-371) that MA tyrosine phosphorylation participates in facilitating HIV-1 nuclear import. Even though under some experimental conditions the point made by Freed et al. is valid, Trono and Gallay feel at this stage that technical differences, for instance related to the use of different m.o.i. values, explain the discrepancy between the different groups' results. KW - core proteins KW - HIV-1 infections KW - human diseases KW - infection KW - macrophages KW - microbiology KW - pathogenesis KW - phenotypes KW - phosphorylation KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003203&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. AU - Lubin, J. H. AU - Boice, J. D., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 1 SP - 49 EP - 57 SN - 0027-8874 AD - Lubin, J. H.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972008019. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 10043-92-2. Subject Subsets: Public Health N2 - To provide more information on the risk of lung cancer from indoor radon, a meta-analysis of all case-control studies that included at least 200 case subjects each and that used long-term indoor radon measurements was conducted. Eight studies were available and included a total of 4263 lung cancer case subjects and 6612 control subjects. From the published results of each study, confounder-adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) for categories of radon concentration were obtained, and weighted linear regression analyses were performed. The combined trend in the RR was significantly different from zero (two-sided P = 0.03), and an estimated RR of 1.14 (95% CI = 1.0-1.3) at 150 Bq/m³ was found. An influence analysis indicated that no single study dominated the combined results. The exposure-response trend was similar to model-based extrapolations from underground miners and to RRs computed directly from miners with low cumulative exposures. However there were significant differences in the study-specific estimates of the exposure response (two-sided P <0.001), which were not explained by study differences in percent of the defined exposure interval covered by radon measurements, mean number of residences per subject, and other factors. The results of the meta-analysis indicated that the risk from indoor radon is not likely to be markedly greater than that predicted from miners and that the negative exposure response reported in some ecological studies is likely due to model misspecification or uncontrolled confounding and can be rejected. It is concluded that the studies of underground miners remain the best source of data to use to assess risk from indoor radon. KW - buildings KW - dwellings KW - epidemiology KW - human diseases KW - lung cancer KW - lungs KW - miners KW - neoplasms KW - public health KW - radiation KW - radon KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancer sites KW - cancers KW - Human Health and the Environment (VV500) KW - Occupational Health and Safety (VV900) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease. AU - Levin, M. C. AU - Krichavsky, M. AU - Fox, R. J. AU - Lehky, T. AU - Jacobson, S. AU - Fox, C. AU - Kleghorn, F. AU - White, J. AU - Young, N. AU - Edwards, R. J. AU - Jack, N. E. AU - Bartholomew, C. T2 - Blood JO - Blood JF - Blood Y1 - 1997/// VL - 89 IS - 1 SP - 346 EP - 348 SN - 0006-4971 AD - Levin, M. C.: Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurologic Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19972002349. Publication Type: Correspondence. Language: English. Number of References: 12 ref. KW - autoimmune diseases KW - bone marrow KW - clinical aspects KW - HTLV infections KW - human diseases KW - latent infections KW - neurology KW - Deltaretrovirus KW - human t-cell lymphotropic virus type I KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002349&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Birth cohort and calendar period trends in breast cancer mortality in the United States and Canada. AU - Tarone, R. E. AU - Chu, K. C. AU - Gaudette, L. A. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 3 SP - 251 EP - 256 SN - 0027-8874 AD - Tarone, R. E.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19972009446. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health N2 - Breast cancer mortality rates during 1969-92 for white women and black women in 4 regions of the USA and for all women throughout Canada were compared to identify racial, regional and temporal differences. Differences and trends in the rates were evaluated in view of breast cancer risk factors and relevant medical interventions. Age-period-cohort models were fitted to the data, and changes in birth cohort trends (suggesting a change in a breast cancer risk factor or protective factor) and calendar period trends (suggesting, in part, the impact of new or improved medical interventions) were examined. Breast cancer mortality rates for white women were significantly higher in the North-east than in any other region of the USA (P <0.005); the rates for black women were not. Birth cohort trends for all women were similar until 1940, with a moderation of mortality risk beginning around 1924. A marked moderation of risk by 4-year birth cohorts was observed for US white women born after 1950, whereas stable or slightly decreasing trends were observed for US black women and Canadian women. For women born from 1924 to 1938, fertility rates increased for all 3 groups; after 1950, they declined uniformly. Looking at temporal effects, the slope of the mortality calendar period trend increased in the 1980s compared with the 1970s for all women. In the last calendar period, 1991-92, a trend of decreasing mortality rates was found for white women in the USA and for Canadian women. Possible explanations for these observations are discussed. KW - blacks KW - breast KW - breast cancer KW - detection KW - diagnosis KW - ethnic groups KW - fertility KW - human diseases KW - mortality KW - neoplasms KW - risk factors KW - screening KW - therapy KW - trends KW - women KW - Canada KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - breasts KW - cancer sites KW - cancers KW - death rate KW - screening tests KW - therapeutics KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009446&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication. AU - Sloand, E. M. AU - Young, N. S. AU - Kumar, P. AU - Weichold, F. F. AU - Sato, T. AU - Maciejewski, J. P. JO - Blood JF - Blood Y1 - 1997/// VL - 89 IS - 4 SP - 1357 EP - 1363 SN - 0006-4971 AD - Sloand, E. M.: National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Correspondence address: J. P. Maciejewski, University of Nevada, School of Medicine, Department of Microbiology-320, Howard Medical Building, Reno, NV 89557-0046, USA. N1 - Accession Number: 19972004407. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - Increased Fas-receptor (CD95) expression on CD4+ and CD8+ lymphocytes was seen among 86 HIV-1-infected patients compared with normal blood donor controls; individuals with AIDS and a history of opportunistic infection had significantly more Fas receptor expression than did asymptomatic HIV-infected persons and normal controls. Soluble and membrane-bound forms of Fas ligand were produced in greater amounts by peripheral blood mononuclear cell cultures and in plasma from HIV-1-infected persons than from normal controls. Furthermore, triggering of lymphocytes from HIV-infected persons by the agonistic anti-Fas monoclonal antibody, CH 11, increased levels of interleukin-1β converting enzyme, a protein associated with apoptosis. KW - acquired immune deficiency syndrome KW - apoptosis KW - CD4+ lymphocytes KW - HIV-1 infections KW - human diseases KW - immune response KW - immunology KW - immunopathology KW - monoclonal antibodies KW - pathogenesis KW - receptors KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4+ cells KW - Fas ligand KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004407&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National Institutes of Health Consensus Development Conference Statement: breast cancer screening for women ages 40-49, January 21-23, 1997. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 14 SP - 1015 EP - 1026 SN - 0027-8874 AD - Correspondence address: B. Hall, Office of Medical Applications of Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982001718. Publication Type: Journal Article. Corporate Author: USA, National Institutes of Health Consensus Development Panel Language: English. Number of References: 93 ref. Subject Subsets: Public Health KW - breast KW - breast cancer KW - human diseases KW - neoplasms KW - screening KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - breasts KW - cancers KW - screening tests KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001718&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Benzene and the dose-related incidence of hematologic neoplasms in China. AU - Hayes, R. B. AU - Yin, S. N. AU - Dosemeci, M. AU - Li, G. N. AU - Wacholder, S. AU - Travis, L. B. AU - Li, C. Y. AU - Rothman, N. AU - Hoover, R. N. AU - Linet, M. S. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 14 SP - 1065 EP - 1071 SN - 0027-8874 AD - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982001719. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 71-43-2. Subject Subsets: Tropical Diseases N2 - A cohort of 74 828 benzene-exposed and 35 805 unexposed workers employed during 1972-87 in 12 cities in China was identified and followed to determine the incidence of haematological neoplasms and related disorders. Relative risks (RRs) (ratios of incidence rates for specific haematological neoplasms and related disorders in the benzene-exposed group to incidence rates in the unexposed group) were determined by use of Poisson regression analysis. For workers historically exposed to benzene at mean levels of <10 p.p.m., the RR for all haematological neoplasms combined was 2.2 (95% confidence interval [CI]=1.1-4.2) and, for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes, the RR was 3.2 (95% CI=1.0-4.2), and for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes, the RR was 3.2 (95% CI=1.0-10.1). For individuals who were occupationally exposed to benzene at constant levels of ≥25 p.p.m., the RR for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes was 7.1 (95% CI=2.1-23.7). Workers with 10 or more years of benzene exposure had an RR of developing non-Hodgkin's lymphoma of 4.2 (95% CI=1.1-15.9), and the development of this neoplasm was linked most strongly to exposure that had occurred at least 10 years before diagnosis (distant exposure) (P for trend=0.005, two-sided). In contrast, the risk for the combination of acute non-lymphocytic leukaemia and related myelodysplastic syndromes was significantly increased among those with more recent benzene exposure (P for trend=0.003, two-sided), but it was not linked to distant exposure (P for trend=0.51, two-sided). It is suggested that benzene exposure is associated with a spectrum of haematological neoplasms and related disorders in humans. Risks for these conditions are elevated at mean benzene-exposure levels of <10 p.p.m. and show a tendency to rise with increasing levels of exposure. The temporal pattern of benzene exposure appears to be important in determining the risk of developing specific diseases. KW - benzene KW - epidemiology KW - exposure KW - human diseases KW - incidence KW - leukaemia KW - lymphoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - risk KW - risk factors KW - workers KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - blood cancer KW - cancers KW - leucaemia KW - leukemia KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001719&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. AU - Hildesheim, A. AU - Anderson, L. M. AU - Chen ChienJen AU - Cheng YuJuen AU - Brinton, L. A. AU - Daly, A. K. AU - Reed, C. D. AU - Chen IHow AU - Caporaso, N. E. AU - Hsu MowMing AU - Chen JenYang AU - Idle, J. R. AU - Hoover, R. N. AU - Yang CzauSiung AU - Chhabra, S. K. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 16 SP - 1207 EP - 1212 SN - 0027-8874 AD - Hildesheim, A.: National Institutes of Health, Executive Plaza North, Rm 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010479. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Tropical Diseases N2 - A case-control study was conducted to investigate whether variations in the CYP2E1 gene (for cytochrome P450 2E1 enzyme) affect the risk of developing nasopharyngeal cancer. 364 patients with nasopharyngeal carcinoma (96% of 378 eligible patients) and 320 control subjects (86% of 374 eligible subjects) from Taiwan were studied during 1991-94. A risk factor questionnaire was administered to participants to assess factors postulated to be linked to nasopharyngeal carcinoma. Peripheral blood was obtained from all subjects and DNA was purified from nucleated cells. A polymerase chain reaction-based restriction fragment length polymorphism assay that used the restriction enzymes Rsa I and Dra I was used to detect wild-type and variant forms of the CYP2E1 gene. Individuals homozygous for an allele of the CYP2E1 gene that is detected by Rsa I digestion (c2 allele) were found to have an increased risk of nasopharyngeal carcinoma (relative risk (RR)=2.6; 95% confidence interval (CI)=1.2-5.7); this effect was limited to non-smokers (RR=9.3; 95% CI=2.7-32) and was not affected by alcohol consumption. It is suggested that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk. KW - carcinoma KW - epidemiology KW - genes KW - human diseases KW - nasopharynx KW - neoplasms KW - patients KW - polymorphism KW - questionnaires KW - restriction fragment length polymorphism KW - risk factors KW - Taiwan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - South East Asia KW - Asia KW - cancers KW - Formosa KW - nasopharyngeal carcinoma KW - RFLP KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010479&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breast implants and cancer. AU - Brinton, L. A. AU - Brown, S. L. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 18 SP - 1341 EP - 1349 SN - 0027-8874 AD - Brinton, L. A.: Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19982005844. Publication Type: Journal Article. Language: English. Number of References: 118 ref. N2 - This general review of studies examines evidence on the long-term safety of silicon and polyurethane foam-covered breast implants. Issues discussed include the interference of implants with breast visualization during mammography (and possible delay in breast cancer diagnosis) and studies concerning implants and incidence of sarcomas, multiple myeloma, lymphomas and other cancers. It is concluded that there is currently little evidence to support the concern that breast implants increase the risk of subsequent breast cancer and there is insufficient data to determine any relationship with predisposition to other cancers. KW - breast cancer KW - human diseases KW - mammary glands KW - neoplasms KW - prostheses KW - reviews KW - risk factors KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005844&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. AU - Wideroff, L. AU - Gridley, G. AU - Mellemkjaer, L. AU - Chow, W. H. AU - Linet, M. AU - Keehn, S. AU - Borch-Johnsen, K. AU - Olsen, J. H. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 18 SP - 1360 EP - 1365 SN - 0027-8874 AD - Wideroff, L.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19982005843. Publication Type: Journal Article. Language: English. Number of References: 43 ref. N2 - Discharge records of 109 581 individuals, hospitalized in Denmark with a diagnosis of diabetes during 1977-89, were linked with national cancer registry records to 1993. Cancer incidence in diabetics during this period was, for males, 4666 and for females, 4165. The standardized incidence ratios (SIRs) for primary liver cancer were 4.0 (95% confidence interval (CI)=3.5-4.6) in males and 2.1 (95% CI=1.6-2.7) in females. These SIRs remained elevated with increasing years of follow-up and after exclusion of patients with reported risk factors (e.g. cirrhosis and hepatitis) or patients whose cancers were diagnosed at autopsy. Kidney cancer risk was elevated, with SIRs of 1.4 (95% CI=1.2-1.6) in males and 1.7 (95% CI=1.4-1.9) in females. For both sexes combined, the SIR for pancreatic cancer was 2.1 (95% CI=1.9-2.4), with a follow-up time of 1-4 years; this SIR declined to 1.3 (95% CI=1.1-1.6) after 5-9 years of follow-up. Excess risks were also observed for biliary tract and endometrial cancers. The SIRs for kidney and endometrial cancers were lower after exclusion of diabetics with reported obesity. Elevated risks of oral/pharyngeal and oesophageal cancers were observed in cohort members entering at age <50 years, which it is suggested may reflect the high preponderance of non-insulin dependent diabetes mellitus in these cohort members. It is concluded that patients hospitalized with a diagnosis of diabetes are at a notably higher risk of developing primary liver cancer. KW - diabetes KW - diabetes mellitus KW - digestive tract KW - endometrium KW - epidemiology KW - females KW - incidence KW - kidneys KW - liver KW - liver cancer KW - males KW - neoplasms KW - pancreas KW - risk factors KW - Denmark KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - endometrial area KW - gastrointestinal tract KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005843&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk of second malignant neoplasms among long-term survivors of testicular cancer. AU - Travis, L. B. AU - Curtis, R. E. AU - Storm, H. AU - Hall, P. AU - Holowaty, E. AU - Leeuwen, F. E. van AU - Kohler, B. A. AU - Pukkala, E. AU - Lynch, C. F. AU - Andersson, M. AU - Bergfeldt, K. AU - Clarke, E. A. AU - Wiklund, T. AU - Stoter, G. AU - Gospodarowicz, M. AU - Sturgeon, J. AU - Fraumeni, J. F., Jr. AU - Boice, J. D., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1997/// VL - 89 IS - 19 SP - 1429 EP - 1439 SN - 0027-8874 AD - Travis, L. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19982005409. Publication Type: Journal Article. Language: English. Number of References: 70 ref. N2 - A total of 28843 patients diagnosed with a first primary cancer of the testis between 1 January, 1935 and 31 December, 1993 and who survived ≥1 year, were identified within 16 population-based tumour registries in the USA, Canada, Sweden, Finland, Denmark and the Netherlands. 3300 men had survived >20 years. Second cancers were reported in 1406 men (observed-to-expected ratio (O/E)=1.43; 95% confidence interval=1.36-1.51), with significant excesses noted for acute lymphoblastic leukaemia (O/E=5.20), acute nonlymphocytic leukaemia (O/E=3.07), melanoma (O/E=1.69), non-Hodgkin's lymphoma (O/E=1.88) and cancers of the stomach (O/E=1.95), colon (O/E=1.27), rectum (O/E=1.41), pancreas (O/E=2.21), prostate (O/E=1.26), kidney (O/E=1.50), bladder (O/E=2.02), thyroid (O/E=2.92) and connective tissue (O/E=3.16). Overall risk was similar after seminomas (O/E=1.42) or nonseminomatous tumours (O/E=1.50). Risk of solid tumours increased with time since the diagnosis of testicular cancer, yielding an O/E=1.54 (O=369) among 20-year survivors (2-sided P for trend=0.00002). Secondary leukaemia was associated with both radiotherapy and chemotherapy, but excess cancers of the stomach, bladder and possibly, pancreas were associated mainly with radiotherapy. It is concluded that men with testicular cancer continue to be at significantly elevated risk of second malignant neoplasms for over 2 decades following initial diagnosis and that many factors may be involved. KW - bladder KW - colon KW - colorectal cancer KW - human diseases KW - kidneys KW - leukaemia KW - lymphoma KW - malignant course KW - melanoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - pancreas KW - prostate KW - radiotherapy KW - rectum KW - risk KW - stomach KW - testes KW - thyroid gland KW - America KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood cancer KW - cancers KW - leucaemia KW - leukemia KW - testicles KW - thyroid KW - urinary bladder KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005409&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Physical mapping of a defect in Plasmodium falciparum male gametocytogenesis to an 800 kb segment of chromosome 12. AU - Guinet, F. AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1997/// VL - 90 IS - 1 SP - 343 EP - 346 SN - 0166-6851 AD - Guinet, F.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980804658. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology N2 - Studies on chromosome 12 of the poorly mosquito-infective Dd2 clone of Plasmodium falciparum by pulsed-field gradient electrophoresis showed that the mdv defect did not result from large deletions or rearrangements that would have been detected in the 800 kb chromosome segment at the resolution of the study (20-50 kb). It is suggested that small scale rearrangements or localized mutations that produce changes in the structure and expression of one or more genes may be responsible for the defect. KW - chromosome maps KW - chromosomes KW - gametes KW - gametocytes KW - gene mapping KW - genes KW - genetics KW - malaria KW - mapping KW - mutations KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - cartography KW - gametocytogenesis KW - rearrangements KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804658&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparum Pfs40, renamed Pf39, is localized to an intracellular membrane-bound compartment and is not sexual stage-specific. AU - Templeton, T. J. AU - Fujioka, H. AU - Aikawa, M. AU - Parker, K. C. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1997/// VL - 90 IS - 1 SP - 359 EP - 365 SN - 0166-6851 AD - Templeton, T. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980804661. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Protozoology N2 - Studies of the product of the presumed Pfs40 gene of Plasmodium falciparum showed that it is not expressed on the parasite cell surface and is therefore likely to be a protein distinct from the previously described sexual-stage specific 40-kDa cell surface protein. The cloned gene was characterized and defined, and renamed Pf39, as a protein expressed in both sexual and asexual stages. It is localized to an intracellular membranous compartment suggestive of endoplasmic reticulum. KW - endoplasmic reticulum KW - genes KW - molecular genetics KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - Pf39 KW - Pfs40 KW - sexual stages KW - stage specificity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Non-ulcerative cutaneous leishmaniasis in Honduras fails to respond to topical paromomycin. AU - Neva, F. A. AU - Ponce, C. AU - Ponce, E. AU - Kreutzer, R. AU - Modabber, F. AU - Olliaro, P. JO - Transactions of the Royal Society of Tropical Medicine and Hygiene JF - Transactions of the Royal Society of Tropical Medicine and Hygiene Y1 - 1997/// VL - 91 IS - 4 SP - 473 EP - 475 SN - 0035-9203 AD - Neva, F. A.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19980801739. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7542-37-2. Subject Subsets: Protozoology; Tropical Diseases N2 - A double-"blind", placebo-controlled trial of topical therapy with 15% paromomycin and 10% urea in white paraffin was carried out on 53 patients with non-ulcerating cutaneous leishmaniasis in Honduras. Although the treatment was not effective, 18 of 26 isolates at one of the study sites (San Juan Bautista) were found by isoenzyme typing to be Leishmania mexicana. The lesions from which the L. mexicana isolates were recovered were clinically indistinguishable from those caused by L. chagasi [L. infantum chagasi], the aetiologic agent previously found for this form of leishmaniasis. This is the first documented report of L. mexicana in Honduras. KW - antiprotozoal agents KW - cutaneous leishmaniasis KW - drug therapy KW - geographical distribution KW - human diseases KW - leishmaniasis KW - lesions KW - new geographic records KW - parasites KW - paromomycin KW - pathology KW - skin lesions KW - Honduras KW - Leishmania infantum chagasi KW - Leishmania mexicana KW - man KW - protozoa KW - Leishmania infantum KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - CACM KW - Central America KW - America KW - Developing Countries KW - Latin America KW - aminosidine KW - chemotherapy KW - leishmaniosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801739&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Complex polymorphisms in an ~330 kDa protein are linked to chloroquine-resistant P. falciparum in southeast Asia and Africa. AU - Su XinZhuan AU - Kirkman, L. A. AU - Fujioka, H. AU - Wellems, T. E. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1997/// VL - 91 IS - 5 SP - 593 EP - 603 SN - 0092-8674 AD - Su XinZhuan: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980803849. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Protozoology; Tropical Diseases N2 - The production of a cross between a Plasmodium falciparum chloroquine sensitive (HB3) and a P. falciparum chloroquine resistant clone (Dd2) provided a genetic approach to study the chloroquine resistance mechanism. Chloroquine resistance in the P. falciparum cross mapped as a Mendelian trait to a 36 kb segment of chromosome 7. This segment harboured cg2, a gene encoding a unique ~330 kDa protein with complex polymorphisms. It is suggested that a specific set of polymorphisms in 20 chloroquine-resistant P. falciparum isolates from Asia and Africa, in contrast with numerous differences in 21 sensitive P. falciparum isolates, indicate selection of a cg2 allele originating in Indochina over 40 years ago. One chloroquine-sensitive clone exhibited this allele, suggesting the occurrence of another resistance component. P. falciparum from South America had cg2 polymorphisms consistent with a separate origin of resistance. The CG2 protein was found at the parasite periphery, a site of chloroquine transport, and in association with haemozoin of the digestive vacuole. KW - amino acid sequences KW - antimalarials KW - antiprotozoal agents KW - chloroquine KW - chromosomes KW - drug resistance KW - genes KW - genetic polymorphism KW - human diseases KW - malaria KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - Africa KW - Indochina KW - South America KW - South East Asia KW - man KW - Plasmodium falciparum KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - South East Asia KW - Asia KW - America KW - biochemical genetics KW - DNA sequences KW - protein sequences KW - Southeast Asia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803849&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum hepatitis G virus RNA in patients with chronic viral hepatitis. AU - Marrone, A. AU - Shih WaiKuo AU - Nakatsuji, Y. AU - Alter, H. J. AU - Lau, D. AU - Vergalla, J. AU - Hoofnagle, J. H. JO - American Journal of Gastroenterology JF - American Journal of Gastroenterology Y1 - 1997/// VL - 92 IS - 11 SP - 1992 EP - 1996 SN - 0002-9270 AD - Marrone, A.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982005081. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9008-11-1, 36791-04-5, 63231-63-0. Subject Subsets: Public Health N2 - To study the role of hepatitis G virus (HGV) in the course of chronic viral hepatitis, stored serum samples from 108 patients with chronic hepatitis B and 99 patients with chronic hepatitis C who participated in trials (in the USA) of α-interferon or ribavirin between 1984 and 1991 were evaluated for the presence of hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA by branched DNA and for the presence of HGV RNA by polymerase chain reaction (PCR), using primers from the NS5 region of the genome. Initially, 20 (19%) patients with hepatitis B and 11 (11%) with hepatitis C had HGV RNA in their serum. Patients with and without HGV infection were similar with regard to clinical features, laboratory tests and hepatic histology. HGV RNA levels fell during interferon therapy and became undetectable in those receiving the highest doses; however, HGV RNA levels returned to pretreatment values when therapy was stopped. With ribavirin therapy, HGV RNA levels did not change. Two- to 12-year follow-up serum samples were available from 17 initially HGV RNA-positive patients, of whom only 10 (59%) were still positive. It is concluded that HGV infection is common among patients with chronic hepatitis B and C but has little effect on the short-term course of disease or response to therapy. HGV RNA levels are suppressed but not eradicated by α-interferon and are unaffected by ribavirin treatment. Spontaneous loss of HGV RNA occurs over time in a proportion of patients. KW - chronic infections KW - clinical aspects KW - disease course KW - drug therapy KW - epidemiology KW - hepatitis B KW - hepatitis C KW - human diseases KW - infections KW - interferon KW - liver diseases KW - ribavirin KW - RNA KW - viral diseases KW - viral hepatitis KW - USA KW - Flavivirus KW - gb virus c KW - hepatitis B virus KW - hepatitis C virus KW - hepatitis g virus KW - man KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - Hepacivirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - clinical picture KW - disease progression KW - gb virus KW - ribonucleic acid KW - tribavirin KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005081&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12. AU - Wynn, T. A. A2 - Cordeiro, R. A2 - Moqbel, R. A2 - Weller, P. F. JO - Memorias do Instituto Oswaldo Cruz, Supplement JF - Memorias do Instituto Oswaldo Cruz, Supplement Y1 - 1997/// VL - 92 SP - 105 EP - 108 AD - Wynn, T. A.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980805047. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 308067-57-4. Subject Subsets: Helminthology N2 - The effects of interleukin (IL)-12 on immunity to schistosomiasis in mice immunized once (1X) or 3 times (3X) with attenuated cercariae of Schistosoma mansoni are reviewed. While multiply-immunized/saline-treated mice demonstrated a 70-80% reduction in parasite burden, 3X/IL-12-vaccinated animals displayed a striking >90% reduction in challenge infection, with many mice demonstrating complete protection. 3X/saline-vaccinated mice produced a mixed Th1/Th2-type cytokine response, while 3X/IL-12 immunized animals displayed a dominant Th1-type response. The animals vaccinated with IL-12 also showed a highly significant increase in total immunoglobulin titres specific for IrV-5, a known protective antigen. 3X/IL-12 serum alone, when transferred to naive mice, reduced worm burdens by over 60% while 3X/saline serum transferred significantly less protection. Nevertheless, animals vaccinated in the presence of IL-12 also developed macrophages with enhanced nitric oxide dependent killing activity against the parasites. These observations suggest that IL-12, initially described as an adjuvant for cell-mediated immunity, may also be used as an adjuvant for promoting both humoral and cell-mediated protective responses. KW - adjuvants KW - antigens KW - cercariae KW - cytokines KW - experimental infections KW - helminths KW - immune response KW - immunization KW - immunoglobulins KW - interleukin 12 KW - laboratory animals KW - parasites KW - reviews KW - schistosomiasis KW - T lymphocytes KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - antigenicity KW - bilharzia KW - bilharziasis KW - gamma-globulins KW - immune globulins KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805047&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. AU - Pantaleo, G. AU - Demarest, J. F. AU - Schacker, T. AU - Vaccarezza, M. AU - Cohen, O. J. AU - Daucher, M. AU - Graziosi, C. AU - Schnittman, S. S. AU - Quinn, T. C. AU - Shaw, G. M. AU - Perrin, L. AU - Tambussi, G. AU - Lazzarin, A. AU - Sekaly, R. P. AU - Soudeyns, H. AU - Corey, L. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 1 SP - 254 EP - 258 SN - 0027-8424 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972001408. Publication Type: Journal Article. Language: English. Number of References: 40 ref. N2 - Following infection of the host with a virus, the delicate balance between virus replication/spread and the immune response to the virus determines the outcome of infection, i.e., persistence versus elimination of the virus. It is unclear, however, what relative roles immunological and virological factors play during primary viral infection in determining the subsequent clinical outcome. By studying a cohort of subjects with primary HIV infection, it has been demonstrated that qualitative differences in the primary immune response to HIV, but not quantitative differences in the initial levels of viremia are associated with different clinical outcomes. Taken together, these results provide evidence that the initial interaction between the virus and the immune system of the host is an important determining factor in the subsequent clinical outcome, and that immunological factors operative during primary infection, as much as or more thanal virologic factors are critical determinants of the ultimate progression of HIV disease. KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - immunopathology KW - pathogenesis KW - replication KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001408&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I. AU - Brzeska, H. AU - Knaus, U. G. AU - Wang ZhenYuan AU - Bokoch, G. M. AU - Korn, E. D. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 4 SP - 1092 EP - 1095 SN - 0027-8424 AD - Brzeska, H.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, 9000 Rockville Pike, 3 Center Drive MSC 0301, Bethesda, MD 20892-0301, USA. N1 - Accession Number: 19970804414. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Protozoology N2 - The catalytic domain of Acanthamoeba myosin I heavy chain kinase (MIHCK) has extensive sequence similarity to the p21-activated kinase (PAK)/STE20 family of kinases from mammals and yeast, which are activated by small GTP-binding proteins. MIHCK, the 35-kDa catalytic domain of MIHCK (35K), and PAK1 were assayed using 4 different synthetic peptides (PC9, PCJ, PK12, PAK13) as substrates. The concentration of each of the peptide substrates was 0.4 mM and the kinase concentrations were 3.36 µg/ml for MIHCK, 5.36 µg/ml for 35K, and 2.36 µg/ml for PAK. PAK1 had similar substrate specificity to MIHCK exhibiting the highest relative kinase activity with a substrate which had tyrosine residues 2 positions C-terminal to the phosphorylatable serine (PC9). PAK1 also phosphorylated the heavy chain (1 mol of Pi per mol), and activated Acanthamoeba myosin I in a very similar manner to MIHCK. It is concluded that these results, together with the known involvement of Acanthamoeba myosin I, yeast myosin I, STE20, PAK, and small GTP-binding proteins in membrane- and cytoskeleton-associated morphogenetic transformations and activities, suggest that myosins may be physiological substrates for the PAK/STE20 family and thus mediators of these events. KW - biochemistry KW - kinases KW - myosins KW - parasites KW - Acanthamoeba KW - protozoa KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunity to retroviral infection: the Friend virus model. AU - Hasenkrug, K. J. AU - Chesebro, B. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 15 SP - 7811 EP - 7816 SN - 0027-8424 AD - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA. N1 - Accession Number: 19972008317. Publication Type: Journal Article. Language: English. Number of References: 95 ref. N2 - Friend virus infection of adult immuno-competent mice is a well established model for studying genetic resistance to infection by an immunosuppressive retrovirus. This paper reviews both the genetics of immune resistance and the types of immune responses required for recovery from infection. Specific major histocompatibility complex (MHC) class I and II alleles are necessary for recovery, as is a non-MHC gene, Rfv-3, which controls virus-specific antibody responses. In concordance with these genetic requirements are immunological requirements for cytotoxic T lymphocyte, T helper, and antibody responses, each of which provides essential non-overlapping functions. The complexity of responses necessary for recovery from Friend virus infection has implications for both immunotherapies and vaccines. For example, it is shown that successful passive antibody therapy is dependent on MHC type because of the requirement for T cell responses. For vaccines, successful immunization requires priming of both T cell and B cell responses. In vivo depletion experiments demonstrate different requirements for CD8+ T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed. KW - antibodies KW - B lymphocytes KW - cytotoxicity KW - genetics KW - immune response KW - immunization KW - immunology KW - major histocompatibility complex KW - responses KW - reviews KW - T lymphocytes KW - vaccines KW - mice KW - retroviridae KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - RNA Reverse Transcribing Viruses KW - viruses KW - B cells KW - histocompatibility complex KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - MHC antigens KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for rapid disappearance of initially expanded HIV-1 specific CD8+ T cell clones during primary HIV infection. AU - Pantaleo, G. AU - Soudeyns, H. AU - Demarest, J. F. AU - Vaccarezza, M. AU - Graziosi, C. AU - Paolucci, S. AU - Daucher, M. B. AU - Cohen, O. J. AU - Denis, F. AU - Biddison, W. E. AU - Sekaly, R. P. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 18 SP - 9848 EP - 9853 SN - 0027-8424 AD - Pantaleo, G.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.Correspondence address [Pantaleo, G.]: Laboratory of AIDS Immunopathogenesis, Department of Medicine, Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. N1 - Accession Number: 19972008629. Publication Type: Journal Article. Language: English. Number of References: 48 ref. N2 - Down-regulation of the initial burst of viraemia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analysed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance of clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection. KW - cell mediated immunity KW - clones KW - cytotoxic T lymphocytes KW - cytotoxicity KW - epitopes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunology KW - lymphocytes KW - mutations KW - receptors KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - cellular immunity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - primary infections KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008629&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel virus in swine is closely related to the human hepatitis E virus. AU - Meng XiangJin AU - Purcell, R. H. AU - Halbur, P. G. AU - Lehman, J. R. AU - Webb, D. M. AU - Tsareva, T. S. AU - Haynes, J. S. AU - Thacker, B. J. AU - Emerson, S. U. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 18 SP - 9860 EP - 9865 SN - 0027-8424 AD - Meng XiangJin: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0740, Bethesda, MD 20892, USA. N1 - Accession Number: 19982203589. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science N2 - A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Serum samples from pigs in 15 commercial herds in the midwestern USA were tested for HEV using an ELISA. The majority of pigs ≥3 months of age were seropositive. Young pigs naturally infected by swine HEV were clinically healthy but had microscopic evidence of hepatitis, and developed viraemia before seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. It is suggested that the discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis. KW - amino acid sequences KW - ELISA KW - hepatitis KW - nucleotide sequences KW - phylogeny KW - zoonoses KW - USA KW - hepatitis E virus KW - man KW - pigs KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sus scrofa KW - Sus KW - Suidae KW - Suiformes KW - Artiodactyla KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - DNA sequences KW - enzyme linked immunosorbent assay KW - hogs KW - protein sequences KW - swine KW - United States of America KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982203589&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence. AU - Ahlers, J. D. AU - Takeshita, T. AU - Pendleton, C. D. AU - Berzofsky, J. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 20 SP - 10856 EP - 10861 SN - 0027-8424 AD - Ahlers, J. D.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010620. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus, one should be able to increase viral peptide binding to the MHC in the rational design of synthetic peptide vaccines. The T1 helper peptide from the HIV-1 envelope protein was made more immunogenic for inducing T-cell proliferation to the native sequence by replacing a residue that exerts an adverse influence on peptide binding to an MHC class II molecule. Mice immunized with vaccine constructs combining the more potent Th helper (Th) epitope with a cytotoxic T lymphocyte (CTL) determinant developed greatly enhanced CTL responses. Use of class II MHC-congenic mice confirmed that the enhancement of CTL response was due to class II-restricted help. Thus, enhanced T-cell help is key for optimal induction of CTLs, and by modification of the native immunogen to increase binding to the MHC, it is possible to develop second-generation vaccine constructs that enhance both Th cell activation and CTL induction. KW - animal models KW - antigens KW - cells KW - cytotoxicity KW - envelope proteins KW - epitopes KW - human diseases KW - immune response KW - lymphocyte transformation KW - lymphocytes KW - major histocompatibility complex KW - modification KW - peptides KW - proteins KW - T lymphocytes KW - vaccines KW - Human immunodeficiency virus 1 KW - mice KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - antigenicity KW - histocompatibility complex KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunogenicity KW - immunogens KW - immunological reactions KW - T cells KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010620&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. AU - Fidock, D. A. AU - Wellems, T. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 20 SP - 10931 EP - 10936 SN - 0027-8424 AD - Fidock, D. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980801874. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9002-03-3, 59-05-2, 500-92-5. Subject Subsets: Protozoology N2 - To investigate suggestions that WR99210 and proguanil act against a target other than the reductase moiety of the Plasmodium falciparum bifunctional dihydrofolate reductase (DHFR)-thymidylate synthase enzyme, P. falciparum was transformed with a variant form of human DHFR selectable by methotrexate. Human DHFR was found to fully negate the antiparasitic effect of WR99210, thus demonstrating that the only significant action of WR99210 is against parasite DHFR. Although the human enzyme also resulted in greater resistance to cycloguanil, no decrease was found in the level of susceptibility of transformed parasites to proguanil, thus providing evidence of intrinsic activity of this parent compound against a target other than DHFR. The transformation system described has the advantage that P. falciparum drug-resistant lines are uniformly sensitive to methotrexate and will complement transformation with existing pyrimethamine-resistance markers in functional studies of P. falciparum genes. This system also provides an approach for screening and identifying novel DHFR inhibitors that will be important in combined chemotherapeutic formulations against malaria. KW - antiprotozoal agents KW - biochemistry KW - dihydrofolate reductase KW - drug resistance KW - enzymes KW - human diseases KW - malaria KW - methotrexate KW - parasites KW - proguanil KW - transformation KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - amethopterin KW - chlorguanide KW - chloroguanide KW - dihydrofolate reductase-thymidylate synthase KW - tetrahydrofolate dehydrogenase KW - thymidylate synthase KW - WR99210 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980801874&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. AU - Chun TaeWook AU - Stuyver, L. AU - Mizell, S. B. AU - Ehler, L. A. AU - Mican, J. A. M. AU - Baseler, M. AU - Lloyd, A. L. AU - Nowak, M. A. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 24 SP - 13193 EP - 13197 SN - 0027-8424 AD - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIG, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA. N1 - Accession Number: 19982001869. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-49-2, 63231-63-0. N2 - Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4+ T cells and what role these cells play in the persistence of HIV-1 infection in individuals receiving such treatment. The present study demonstrates that highly purified CD4+ T cells from 13 of 13 patients receiving HAART with an average treatment time of 10 months and with undetectable (<500 copies HIV RNA/ml) plasma viraemia by a commonly used bDNA assay carried integrated proviral DNA and were capable of producing infectious virus upon cellular activation in vitro. Phenotypic analysis of HIV-1 produced by activation of latently infected CD4+ T cells revealed the presence in some patients of syncytium-inducing virus. In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viraemia, suggests persistent active virus replication in vivo. KW - antiviral agents KW - blood plasma KW - combination therapy KW - DNA KW - drugs KW - human diseases KW - human immunodeficiency viruses KW - infection KW - inhibitors KW - latent infections KW - patients KW - proteinase inhibitors KW - proteinases KW - regimens KW - replication KW - RNA KW - T lymphocytes KW - treatment KW - viral load KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - combined modality therapy KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - medicines KW - multimodal treatment KW - pharmaceuticals KW - plasma (blood) KW - protease inhibitors KW - proteases KW - ribonucleic acid KW - T cells KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001869&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. AU - Takemoto, S. AU - Mulloy, J. C. AU - Ceresto, A. AU - Migone, T. S. AU - Patel, B. K. R. AU - Matsuoka, M. AU - Yamaguchi, K. AU - Takatsuki, K. AU - Kamihira, S. AU - White, J. D. AU - Leonard, W. J. AU - Waldmann, T. AU - Franchini, G. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 25 SP - 13897 EP - 13902 SN - 0027-8424 AD - Takemoto, S.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, 37 Convent Drive, Bldg. 37, Rm 6A11 Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982001975. Publication Type: Journal Article. Language: English. Number of References: 42 ref. N2 - These results imply that Janus kinases (JAK) and signal transducer and activators of transcription (STAT) activation is associated with replication of leukaemic cells and that therapeutic approaches aimed at JAK/STAT inhibition may be considered to halt neoplastic growth. KW - adult T-cell leukaemia KW - inhibition KW - kinases KW - lymphocyte transformation KW - neoplasms KW - pathogenesis KW - proteins KW - replication KW - T lymphocytes KW - transcription KW - transcription factors KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - adult T-cell leukemia KW - cancers KW - DNA transcription KW - HTLV-BLV group KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001975&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Asian genotypes of JC virus in native Americans and in a Pacific island population: markers of viral evolution and human migration. AU - Agostini, H. T. AU - Yanagihara, R. AU - Davis, V. AU - Ryschkewitsch, C. F. AU - Stoner, G. L. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1997/// VL - 94 IS - 26 SP - 14542 EP - 14546 SN - 0027-8424 AD - Agostini, H. T.: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982005893. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - A total of 68 Navaho from New Mexico,USA, 25 Flathead from Montana, USA, and 29 Chamorro from Guam, in Micronesia were tested for JC virus. Using PCR amplification of a fragment of the VP1 gene, JCV DNA was detected in the urine of 45 (66%) Navaho, 14 (56%) Flathead, and 20 (69%) Chamorro. Genotyping of viral DNAs in these cohorts by cycle sequencing showed predominantly type 2 (Asian), rather than type 1 (European). The large majority (56-89%) of strains excreted by Native Americans and Pacific Islanders were the type 2A subtype, consistent with the origin of these strains in Asia. These findings indicate that JCV infection of Native Americans predates contact with Europeans, and likely predates migration of Amerind ancestors across the Bering land bridge around 12 000-30 000 years ago. If JCV had already differentiated into stable modern genotypes and subtypes prior to first settlement, the origin of JCV in humans may date from 50 000 to 100 000 years ago or more. It is concluded that JCV may have coevolved with the human species, and that it provides a convenient marker for human migrations in both prehistoric and modern times. KW - epidemiology KW - ethnic groups KW - evolution KW - genotypes KW - human diseases KW - migration KW - strains KW - Guam KW - Montana KW - New Mexico KW - USA KW - JC polyomavirus KW - man KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Oceania KW - Oceania KW - Developing Countries KW - Mariana Islands KW - Micronesia KW - Pacific Islands KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Western States of USA KW - Southwestern States of USA KW - JC virus KW - subtypes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005893&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A simple risk estimates study for oral cavity cancer: practical approach in Indian context. AU - Datta, K. AU - Saha, R. K. AU - Chakrabarti, R. N. JO - Journal of the Indian Medical Association JF - Journal of the Indian Medical Association Y1 - 1997/// VL - 95 IS - 3 SP - 70 EP - 71 SN - 0019-5847 AD - Datta, K.: Chittaranjan National Cancer Institute, Calcutta 700026, India. N1 - Accession Number: 19972008818. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Tropical Diseases N2 - A study was conducted on 131 cases of oral cavity cancer (OCC), 145 cases of oral leukoplakia and a control group of 704 subjects with no oral lesions, to investigate risk factors associated with the development of carcinoma of oral cavity in a hospital based cancer registry in Calcutta, India, during 1990-91. Personal interviews, as well as physical examinations of the subjects enabled evaluation of a variety of potential risk factors. Each potential risk factor such as tobacco chewing, tobacco smoking, snuff dipping, alcohol consumption, bad oral and dental hygiene and age were given certain numerical values. Each subject was first given a scoring and then analysed and correlated with the presenting lesions, if present. Results showed that tobacco chewing and bad oral and dental hygiene contributed mainly to higher scoring. Among the subjects in high risk group (scoring >400) 63% had OCC, 21% had oral leukoplakia and 16% had no clinical oral lesions. Among the medium risk group (scoring 100-400) 6% had OCC, 21% had leukoplakia and 73% had no oral lesions. In low risk group (scoring <100) 8% had leukoplakia and 92% had no clinical oral lesions. Using the scoring system, it is suggested that the high risk group for OCC could be identified from general population and cancer detection tests could be especially directed towards this target group to detect maximum number of cases with minimum possible resources. KW - carcinoma KW - clinical aspects KW - detection KW - human diseases KW - lesions KW - mouth KW - neoplasms KW - oral cancer KW - risk factors KW - risk groups KW - tobacco KW - Asia KW - India KW - West Bengal KW - man KW - Nicotiana KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Solanaceae KW - Solanales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - cancer sites KW - cancers KW - clinical picture KW - leukoplakia KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008818&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Randomized controlled clinical trials of experimental vaccines. AU - Naficy, A. B. AU - Clemens, J. D. AU - Rao, M. R. JO - Bulletin de l'Institut Pasteur JF - Bulletin de l'Institut Pasteur Y1 - 1997/// VL - 95 IS - 4 SP - 187 EP - 196 AD - Naficy, A. B.: National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. N1 - Accession Number: 19982006040. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 33 ref. N2 - Aspects of the design of randomized controlled clinical trials to evaluate the clinical protection conferred by experimental vaccines and to provide further evidence of their safety, as demanded by regulatory agencies before these candidate vaccines can be licensed and introduced into routine public health practice, are discussed. KW - clinical aspects KW - clinical trials KW - experiments KW - human diseases KW - immunization KW - public health KW - reviews KW - safety KW - vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - immune sensitization KW - Health Services (UU350) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changes in carotenoid intake in the United States: The 1987 and 1992 National Health Interview Surveys. AU - Nebeling, L. C. AU - Forman, M. R. AU - Graubard, B. I. AU - Snyder, R. A. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1997/// VL - 97 IS - 9 SP - 991 EP - 996 SN - 0002-8223 AD - Nebeling, L. C.: National Cancer Institute, EPN 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19981414171. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 502-65-8, 127-40-2. Subject Subsets: Human Nutrition N2 - A food frequency questionnaire (FFQ) was collected from a representative sample of respondents to the 1987 and 1992 US National Health Interview Surveys throughout 2 calendar quarters. Black and white adults aged 18-69 years, participated in 1987 (n=8161) and 1992 (n=8341). FFQ data were matched and linked to the US Department of Agriculture-National Cancer Institute carotenoid food composition database for analysis. Mean differences in carotenoid intake over time were compared by sociodemographic characteristics and region of the country, after adjustment for sampling weights in a multiple linear regression model. Mean intake of the carotenoid lutein decreased among white women (18%), among adults aged 40-69 years (16%), among persons with 9-12 years of education (11%), among non-drinkers (18%), among drinkers of 1-6 alcoholic drinks/week (7%), among smokers (former smokers by 11%, current smokers by 7% and never smokers by 9%), among income groups (<$20,000 by 7%, ≥$20,000 by 9%) and residents in the south and northeast USA (by 13% each, respectively). Mean intake of the carotenoid lycopene increased among white men (9%), among adults aged 18-39 years and aged 40-69 years (by 5 and 6%, respectively), among those with 13 years of education or more (12.5%), among alcohol drinkers (by 10 and 7% for 1-6 vs. 7 or more drinks/week, respectively), among former and current smokers (by 6% each), among those with incomes ≥$20,000 (8%) and among residents in the west (16%) and midwest (5%). All differences described were significant. It is concluded that the decrease in lutein intake (from dark green leafy vegetables), particularly in white women, may have public health implications as a result of the recognized inverse association between carotenoid intake and disease risk. KW - age KW - alcoholic beverages KW - carotenoids KW - diet studies KW - education KW - ethnicity KW - lycopene KW - tobacco smoking KW - xanthophyll KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ethnic differences KW - lutein KW - tetraterpenoids KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414171&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietetics and foodservice personnel are ready for team problem solving. AU - Wolf, K. N. AU - Schiller, M. R. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1997/// VL - 97 IS - 9 SP - 997 EP - 1002 SN - 0002-8223 AD - Wolf, K. N.: National Cancer Institute, EPN 211, 6130 Executive Blvd, MSC 7326, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19981414172. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition N2 - 321 dietetics and food service personnel (n=632) in 8 hospitals in Ohio responded to a questionnaire on problem-solving abilities. In general, all respondents were somewhat oriented toward group problem solving and were confident in their problem-solving skills. Problem-solving expertise within the organization decreased for the respondents as the problem moved from their direct work areas to the organization level. Dietitians displayed higher self-efficacy in contributing to problem-solving teams than did food service personnel, indicating a 75% chance that they would contribute whereas all other respondents indicated a 50% chance of contributing. It is concluded that the results of this study generate optimism for involving all dietetics and food service personnel in team problem solving. However, training activities are needed for food service personnel and dietetics professionals. KW - dietitians KW - hospital catering KW - hospital personnel KW - hospitals KW - skills KW - Ohio KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - East North Central States of USA KW - hospital food service KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414172&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Total energy expenditure and the level of physical activity correlate with plasma leptin concentrations in five-year-old children. AU - Salbe, A. D. AU - Nicolson, M. AU - Ravussin, E. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1997/// VL - 99 IS - 4 SP - 592 EP - 595 SN - 0021-9738 AD - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016-5319, USA. N1 - Accession Number: 19971403525. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 169494-85-3. Subject Subsets: Human Nutrition N2 - The purpose of this study was to assess the relationship between fasting plasma leptin concentrations and energy expenditure in 5-year-old Pima Indian children (67 males/76 females). Body composition was assessed by isotopic water dilution (18O) whereas total energy expenditure (TEE) and resting metabolic rate (RMR) were measured using doubly labelled water and indirect calorimetry, respectively. The physical activity level was calculated as the ratio of TEE:RMR. Plasma leptin concentrations were positively correlated to percent body fat (r = 0.84, P<0.0001), but were similar in boys and girls after adjusting for percent body fat. Most importantly, it was found that, independent of the percentage of body fat, plasma leptin concentrations correlated with TEE (in absolute values, r = 0.37, P<0.0001) or adjusted for body size (r = 0.42, P<0.0001) and with physical activity level (r = 0.26, P<0.01), but not RMR. These results suggest that, as in animal models, leptin plays a role in energy expenditure in man. KW - blood KW - body fat KW - children KW - energy exchange KW - energy metabolism KW - leptin KW - obesity KW - physical activity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403525&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New directions in food allergy research. AU - Plaut, M. JO - Journal of Allergy and Clinical Immunology JF - Journal of Allergy and Clinical Immunology Y1 - 1997/// VL - 100 IS - 1 SP - 7 EP - 10 SN - 0091-6749 AD - Plaut, M.: Asthma, Allergy and Inflammation Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Room 4A25, Bethesda, MD 20892-7640, USA. N1 - Accession Number: 19981407127. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - A synopsis is given of a workshop entitled "New Directions in Food Allergy Research" which took place at the National Institutes of Health, Bethesda, MD, USA from July 29-30, 1996. Topics discussed include the clinical manifestations and natural history of food allergies, molecular characterization of allergens, immune responses in the gastrointestinal tract and new advances in allergy research. KW - allergens KW - digestive tract KW - food allergies KW - foods KW - immune response KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - food hypersensitivity KW - gastrointestinal tract KW - immunity reactions KW - immunological reactions KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407127&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety of a fat-reduced diet: the dietary intervention study in children (DISC). AU - Obarzanek, E. AU - Hunsberger, S. A. AU - Horn, L. van AU - Hartmuller, V. V. AU - Barton, B. A. AU - Stevens, V. J. AU - Kwiterovich, P. O. AU - Franklin, F. A. AU - Kimm, S. Y. S. AU - Lasser, N. L. AU - Simons-Morton, D. G. AU - Lauer, R. M. JO - Pediatrics JF - Pediatrics Y1 - 1997/// VL - 100 IS - 1 SP - 51 EP - 59 SN - 0031-4005 AD - Obarzanek, E.: National Heart, Lung and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, Maryland, USA. N1 - Accession Number: 19981415109. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 50-81-7, 7235-40-7, 7440-70-2, 57-88-5, 68-19-9, 9007-73-2, 59-30-3, 7439-95-4, 59-67-6, 7723-14-0, 68-26-8, 83-88-5, 59-43-8, 1406-18-4, 7440-66-6. Subject Subsets: Human Nutrition N2 - The relationship between energy intake from fat and anthropometric, biochemical and dietary measures of nutritional adequacy and safety was examined in a 3-year longitudinal study of 663 children (362 boys and 301 girls), 8-10 years old at baseline, with elevated LDL cholesterol, who were participants of the Dietary Intervention Study in Children. Energy intake from fat was assessed from three 24-h recalls at each time point. Lower intake was not related to anthropometric measures or serum Zn, retinol, albumin, β-carotene or vitamin E. Lower fat intake was related to: higher levels of red blood cell folate and haemoglobin, with a trend toward higher serum ferritin; higher intakes of folate, vitamin C and vitamin A, with a trend toward higher iron intake; lower intakes of Ca, Zn, Mg, P, vitamin B12, thiamin, niacin and riboflavin; increased risk of consuming less than two-thirds of the recommended dietary allowances for Ca in girls at baseline, and Zn and vitamin E in boys and girls at all visits. It is concluded that lower fat intakes during puberty are nutritionally adequate for growth and maintenance of normal levels of nutritional biochemical measures, and are associated with beneficial effects on blood folate and haemoglobin. Although lower fat diets were related to lower self-reported intakes of several nutrients, no adverse effects were observed on blood biochemical measures of nutritional status. KW - anthropometric dimensions KW - ascorbic acid KW - beta-carotene KW - blood KW - boys KW - calcium KW - children KW - cholesterol KW - cyanocobalamin KW - energy intake KW - erythrocytes KW - fat KW - ferritin KW - folic acid KW - girls KW - growth KW - haemoglobin KW - hypercholesterolaemia KW - hyperlipoproteinaemia KW - low density lipoprotein KW - magnesium KW - minerals KW - nicotinic acid KW - nutritional state KW - phosphorus KW - retinol KW - riboflavin KW - safety KW - serum albumin KW - sex differences KW - thiamin KW - trace elements KW - vitamin B12 KW - vitamin E KW - vitamins KW - zinc KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aneurin KW - anthropometric measurements KW - axerophthol KW - blood red cells KW - cobalamin KW - folacin KW - folate KW - hemoglobin KW - hypercholesterinemia KW - hypercholesterolemia KW - hyperlipoproteinemia KW - microelements KW - niacin KW - nutritional status KW - red blood cells KW - thiamine KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin B1 KW - vitamin B2 KW - vitamin C KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors. AU - Cohen, O. J. AU - Vaccarezza, M. AU - Lam, G. K. AU - Baird, B. F. AU - Wildt, K. AU - Murphy, P. M. AU - Zimmerman, P. A. AU - Nutman, T. B. AU - Fox, C. H. AU - Hoover, S. AU - Adelsberger, J. AU - Basseler, M. AU - Arthos, J. AU - Davey, R. T., Jr. AU - Dewar, R. L. AU - Matcalf, J. AU - Schwartzentruber, D. J. AU - Orenstein, J. M. AU - Buchbinder, S. AU - Saah, A. J. AU - Detels, R. AU - Phair, J. AU - Rinaldo, C. AU - Margolick, J. B. AU - Pantaleo, G. AU - Fauci, A. S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1997/// VL - 100 IS - 6 SP - 1581 EP - 1589 SN - 0021-9738 AD - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, 10 Center Drive MSC 1876, Building 10, Room 11B13, Bethesda, MD 20892-1876, USA. N1 - Accession Number: 19972010251. Publication Type: Journal Article. Language: English. Number of References: 61 ref. N2 - HIV-1-infected long-term nonprogressors are a heterogeneous group of individuals with regard to immunological and virological markers of HIV-1 disease. CC chemokine receptor 5 (CCR5) has recently been identified as an important coreceptor for HIV-1 entry into CD4+ T cells. A mutant allele of CCR5 confers a high degree of resistance of HIV-1 infection in homozygous individuals and partial protection against HIV disease progression in heterozygotes. The frequency of CCR5 heterozygotes is increased among HIV-1-infected long-term nonprogressors compared with progressors; however, the host defence mechanisms responsible for nonprogression in CCR5 heterozygotes are unknown. It was hypothesized that nonprogressors who were heterozygous for the mutant CCR5 gene might define a subgroup of nonprogressors with higher CD4+ T-cell counts and lower viral load compared with CCR5 wild-type nonprogressors. However, in a cohort of 33 HIV-1-infected long-term nonprogressors, those who were heterozygous for the mutant CCR5 gene were indistinguishable from CCR5 wild-type nonprogressors with regard to all measured immunological and virological parameters. Although epidemiological data support a role for the mutant CCR5 allele in the determination of the state of long-term nonprogression in some HIV-1-infected individuals, it is not the only determinant. Furthermore, long-term nonprogressors with the wild-type CCR5 genotype are indistinguishable from heterozygotes from an immunological and virological standpoint. KW - chemokines KW - cytokines KW - disease course KW - epidemiology KW - genotypes KW - heterogeneity KW - heterozygosity KW - HIV-1 infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - leukocyte count KW - lymph nodes KW - pathogenesis KW - phenotypes KW - polymorphism KW - receptors KW - T lymphocytes KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cell count KW - disease progression KW - human immunodeficiency virus KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010251&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways. AU - Blauvelt, A. AU - Asada, H. AU - Saville, M. W. AU - Klaus-Kovtun, V. AU - Altman, D. J. AU - Yarchoan, R. AU - Katz, S. I. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1997/// VL - 100 IS - 8 SP - 2043 EP - 2053 SN - 0021-9738 AD - Blauvelt, A.: Dermatology Branch, National Cancer Institute, Building 10, Room 12N238, 10 Center Drive, MSC 1908, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19982000963. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - There is substantial evidence that dendritic cells (DCs) residing within epithelial surfaces (e.g., Langerhans cells) are the initial cells infected with HIV after mucosal exposure to virus. To study DC-HIV interactions in detail, Langerhans cell-like DCs were propagated from cord blood CD34+ cells and from adult blood plastic-adherent peripheral blood mononuclear cells in the presence of cytokines (GM-CSF, IL-4, and/or TNF-α). DCs pulsed overnight with HIVBaL or HIVIIIB were infected productively with both viral subtypes (as assessed by PCR, supernatant p24 protein levels, electron microscopy, and antibody staining). Productive infection could be blocked by anti-CD4 monoclonal antibodies, RANTES (regulated upon activation, normal T cell expressed and secreted) (for HIVBaL), stromal cell-derived factor-1 (for HIVIIIB), or azidothymidine added during the HIV pulse, as well as by blocking DC proliferation. However, pulsing DC with HIVs under these blocking conditions had no effect on the ability of DCs to capture virus and transmit infection to cocultured antigen-stimulated CD4+ T cells. Thus, it is shown by several criteria that (a) productive infection of DCs and (b) the ability of DCs to capture virus are mediated through separate pathways. It is suggested that strategies designed to block mucosal transmission of HIV should consider interfering with both virus infection and virus capture by DCs. KW - antibodies KW - CD4 antigens KW - cells KW - core protein p24 KW - cytokines KW - dendritic cells KW - effects KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immunopathology KW - infection KW - interactions KW - mucosa KW - pathogenesis KW - T lymphocytes KW - transmission KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunopathogenesis KW - mucous membrane KW - p24 KW - p24 antigen KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food intakes of US children and adolescents compared with recommendations. AU - Muñoz, K. A. AU - Krebs-Smith, S. M. AU - Ballard-Barbash, R. AU - Cleveland, L. E. JO - Pediatrics JF - Pediatrics Y1 - 1997/// VL - 100 IS - 3, 1 of 2 SP - 323 EP - 329 SN - 0031-4005 AD - Muñoz, K. A.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19981415110. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - To determine the proportion of young people meeting national recommendations for food group intake and to identify food intake patterns, data from the USDA's 1989-1991 Continuing Surveys of Food Intakes by Individuals were used to estimate food intake. Intake was determined from 3 days of diet by disaggregating foods into their component ingredients and using weights that corresponded to servings. The sample included 3307 subjects, 2-19 years old, living in the USA. Mean numbers of servings per day were below minimum recommendations for all food groups except the dairy group (ages 2 to 11). Percentages of young people meeting recommendations ranged from 30% for fruit, grain, meat, and dairy to 36% for vegetables. 16% of youth did not meet any recommendations, and 1% met all recommendations. The pattern of meeting all recommendations resulted in nutrient intakes above the recommended dietary allowances and was high in fat. Conversely, meeting none of the recommendations resulted in intakes well below the recommended dietary allowances for some nutrients. Total fat and added sugars averaged 35 and 15% of energy, respectively, and levels were similar among most demographic groups. It is concluded that children and adolescents in the USA follow eating patterns that do not meet national recommendations. KW - cereal grains KW - children KW - diet studies KW - fat KW - food groups KW - food intake KW - fruit KW - intake KW - meat KW - milk KW - recommended dietary allowances KW - sugars KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - RDA KW - recommended dietary intakes KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Milk and Dairy Produce (QQ010) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415110&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A simple method for measurement of cell-substrate attachment forces: application to HIV-1 Tat. AU - Channavajjala, L. S. AU - Eidsath, A. AU - Saxinger, W. C. JO - Journal of Cell Science JF - Journal of Cell Science Y1 - 1997/// VL - 110 IS - 2 SP - 249 EP - 256 SN - 0021-9533 AD - Channavajjala, L. S.: Laboratory of Tumor Cell Biology, NIH/National Cancer Institute, 37 Convent Drive, MSC 4255, Bldg 37, Rm 6B04, Bethesda, MD, USA. N1 - Accession Number: 19972005032. Publication Type: Journal Article. Language: English. Number of References: 40 ref. N2 - In order to understand the importance of cell attachment to HIV-1 Tat, the strength of cell attachment to immobilized Tat in microtiter plate wells was quantified by the application of buoyant force. By replacing the attachment medium with dense medium, and subjecting the attached cells in the microtiter plates to centrifugal force in the conventional upright position, weakly binding and strongly binding cells could be discriminated (and separated) by varying the centrifugal speed. The strength of attachment of HT1080 cells to Tat was compared with that of the well-known extracellular matrix (ECM) proteins fibronectin and vitronectin. It was observed that all 3 proteins mediated significant attachment of HT1080 cells both at 4°C and 37°C. However, unlike the ECM proteins, Tat was unable to engage in higher strength binding when the temperature was raised to 37°C. The relatively weak binding of HT1080 cells to Tat (in the order of 3.0 µdynes/picomole of coated Tat) and lack of strengthening of binding to Tat at physiological temperature suggests that this protein does not mimic adhesion molecule function. It is anticipated that the methodology developed and described here will be useful in a wide variety of cell-matrix and cell-cell interaction studies. KW - adhesion KW - application KW - cells KW - fibronectins KW - forces KW - HIV-1 infections KW - human diseases KW - interactions KW - measurement KW - methodology KW - microbiology KW - pathogenesis KW - proteins KW - quantitative techniques KW - regulatory genes KW - substrates KW - tat gene KW - Tat protein KW - temperature KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - buoyancy KW - human immunodeficiency virus type 1 KW - methods KW - metrology KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005032&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nonsurgical therapy for pulmonary hydatid cyst disease. AU - Mawhorter, S. AU - Temeck, B. AU - Chang, R. AU - Pass, H. AU - Nash, T. JO - Chest JF - Chest Y1 - 1997/// VL - 112 IS - 5 SP - 1432 EP - 1436 SN - 0012-3692 AD - Mawhorter, S.: Laboratory of Parasitic Diseases, Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19980803932. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 54965-21-8. Subject Subsets: Helminthology; Public Health; Tropical Diseases N2 - The use of percutaneous drainage and albendazole treatment in a Peruvian patient (who immigrated to the USA in 1985) with a large recurrent, isolated, pulmonary cyst caused by Echinococcus granulosus is described. It is suggested that traditional therapy in this patient would have resulted in severe morbidity. Therapeutic options and possible complications are discussed. KW - albendazole KW - anthelmintics KW - case reports KW - echinococcosis KW - helminths KW - human diseases KW - lungs KW - medical treatment KW - parasites KW - therapy KW - Peru KW - USA KW - Echinococcus KW - Echinococcus granulosus KW - man KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - Echinococcus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Andean Group KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - South America KW - Developed Countries KW - North America KW - OECD Countries KW - cysts KW - hydatid disease KW - hydatidosis KW - parasitic worms KW - therapeutics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803932&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Defects of monocyte interleukin 12 production and humoral immunity in Whipple's disease. AU - Marth, T. AU - Neurath, M. AU - Cuccherini, B. A. AU - Strober, W. JO - Gastroenterology JF - Gastroenterology Y1 - 1997/// VL - 113 IS - 2 SP - 442 EP - 448 SN - 0016-5085 AD - Marth, T.: Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982006416. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 308067-57-4. Subject Subsets: Public Health N2 - Whipple's disease (WD) is a systemic infection in which the causative bacteria typically accumulate within macrophages. The aim of this study was to test whether this macrophage dysfunction is the cause or result of previously shown T-cell defects. In vitro production of interleukin (IL)-12, IL-10, tumour necrosis factor α, interferon γ (IFN-γ), and transforming growth factor β (TGF-β) from purified monocytes and peripheral blood mononuclear cells (PBMCs); cytokine expression on duodenal biopsy specimens; and serum cytokine and immunoglobulin (Ig) levels were tested in 9 patients with WD. Reduced monocyte IL-12 production and decreased IFN-γ secretion by PBMCs in vitro were found, as well as reduced immunohistological staining for IL-12 and IFN-γ, but no decrease in other cytokines was found in patients with WD. A similar but less severe defect in 2 relatives with WD argued for a genetic basis of this abnormality. Serum IgG2, an IFN-γ-dependent Ig subclass, and serum TGF-β levels were reduced in patients with WD. It is suggested that the described monocyte defects in WD may result in a secondary reduction of IFN-γ production and IgG2 serum levels. This provides a rationale for additive immunotherapy in patients with antibiotic-refractory WD. KW - bacterial diseases KW - cytokines KW - human diseases KW - humoral immunity KW - immunity KW - immunoglobulins KW - macrophages KW - monocytes KW - T lymphocytes KW - Whipple's disease KW - Germany KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Western Europe KW - Europe KW - bacterial infections KW - bacterioses KW - bacterium KW - gamma-globulins KW - immune globulins KW - T cells KW - Tropheryma whippelii KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006416&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa. AU - Lau, D. T. Y. AU - Everhart, J. AU - Kleiner, D. E. AU - Park, Y. AU - Vergalla, J. AU - Schmid, P. AU - Hoofnagle, J. H. JO - Gastroenterology JF - Gastroenterology Y1 - 1997/// VL - 113 IS - 5 SP - 1660 EP - 1667 SN - 0016-5085 AD - Lau, D. T. Y.: Liver Diseases Section, Digestive Diseases Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982005090. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9008-11-1. Subject Subsets: Public Health N2 - A total of 103 patients with chronic hepatitis B who underwent interferon (IFN)-α therapy in 3 clinical trials, conducted at the National Institutes of Health, Bethesda, MD, USA during 1984-91, were followed up for serological status, biochemical evidence of liver disease, and liver complications or mortality through 1994. 31 patients (30%) responded to therapy, with loss of hepatitis B e antigen (HBeAg) and viral DNA from serum. Responders were more likely than nonresponders to be women, black, and to have more severe liver disease including cirrhosis (P<0.05). Up to 11 years (mean, 6.2 years) after therapy, a higher percentage of responders than nonresponders were still negative for HBeAg (94% vs. 40%; P<0.001) and hepatitis B surface antigen (71% vs. 8.3%; P<0.001). Overall, the rate of liver-related complications and death did not differ by IFN-α response, but with adjustment for cirrhosis, nonresponders had higher rates of liver-related complications and mortality (hazard ratio, 13.7). It is concluded that the response to IFN-α therapy in chronic hepatitis B is usually a sustained improvement in disease markers and, when cirrhosis is considered, patient outcome. KW - antigens KW - chronic infections KW - cirrhosis KW - clinical aspects KW - complications KW - drug therapy KW - follow up KW - hepatitis B KW - human diseases KW - interferon KW - liver diseases KW - mortality KW - prognosis KW - serology KW - viral diseases KW - USA KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - chemotherapy KW - clinical picture KW - death rate KW - immunogens KW - liver cirrhosis KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005090&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut. AU - Pimenta, P. F. P. AU - Modi, G. B. AU - Pereira, S. T. AU - Shahabuddin, M. AU - Sacks, D. L. JO - Parasitology JF - Parasitology Y1 - 1997/// VL - 115 IS - 4 SP - 359 EP - 369 SN - 0031-1820 AD - Pimenta, P. F. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980500130. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 103782-08-7, 9001-06-3. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - The role of the peritrophic matrix (PM) in the development of Leishmania major infections in Phlebotomus papatasi was investigated by addition of exogenous chitinase to the blood meal, which completely blocked PM formation. Surprisingly, the absence of the PM was associated with the loss of midgut infections. The chitinase was not directly toxic to the parasite, nor were midgut infections lost due to premature expulsion of the blood meal. Most parasites were killed in chitinase-treated flies within the first 4 h after feeding. Substantial early killing was also observed in control flies, suggesting that the lack of PM exacerbates lethal conditions which normally exist in the blood-fed midgut. Early parasite mortality was reversed by soybean trypsin inhibitor. Allosamidin, a specific inhibitor of chitinase, led to a thickening of the PM, and also prevented the early parasite mortality seen in infected flies. Susceptibility to gut proteases was extremely high in transitional-stage parasites, while amastigotes and fully transformed promastigotes were relatively resistant. A novel role for the PM in promoting parasite survival is suggested, in which the PM creates a barrier to the rapid diffusion of digestive enzymes, and limits the exposure of parasites to these enzymes during the time when they are especially vulnerable to proteolytic damage. KW - allosamidin KW - chitinase KW - disease vectors KW - host parasite relationships KW - hydrolysis KW - midgut KW - parasites KW - peritrophic membrane KW - Diptera KW - Leishmania major KW - Phlebotominae KW - Phlebotomus papatasi KW - protozoa KW - Psychodidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500130&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator. AU - Desai, A. AU - Shankar, S. K. AU - Jayakumar, P. N. AU - Chandramuki, A. AU - Gourie-Devi, M. AU - Ravikumar, B. V. AU - Ravi, V. JO - Epidemiology and Infection JF - Epidemiology and Infection Y1 - 1997/// VL - 118 IS - 2 SP - 165 EP - 171 SN - 0950-2688 AD - Desai, A.: Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India. N1 - Accession Number: 19970802266. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - The frequency of cerebral cysticercosis (CC) (Taenia solium metacestode infections) in patients with Japanese encephalitis (JE) was investigated in Bangalore, Karnataka, India, with emphasis on its role in predicting the final clinical outcome. Among 163 confirmed cases of JE, 37.42% (61 of 163) also had CC. This was confirmed by ELISA antibody detection in the cerebrospinal fluid (CSF) of 45 cases, by computed tomography (CT) scan in 6 cases, at autopsy in 3 cases, by CT scan and autopsy in 2 cases, by CSF antibody levels and CT scan in 4 cases, and by CSF antibodies and autopsy in 1 case. The presence of CC was recorded in 24.39% (10 of 41) of the JE cases that recovered, in 39.47% (15 of 38) of the cases that recovered but had neurological problems, and in 53.84% (21 of 39) cases who died. A statistical analysis showed that the coexistence of CC in JE cases indicated a poor outcome. KW - brain KW - brain diseases KW - cerebrospinal fluid KW - cestode infections KW - cestode larvae KW - computed tomography KW - concurrent infections KW - cysticercosis KW - disease prevalence KW - ELISA KW - helminths KW - human diseases KW - interactions KW - Japanese encephalitis KW - metacestodes KW - mixed infections KW - nervous system diseases KW - neurocysticercosis KW - parasites KW - postmortem examinations KW - prognosis KW - Asia KW - India KW - Japanese encephalitis virus KW - man KW - Taenia solium KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - autopsy KW - brain disorders KW - cerebrum KW - enzyme linked immunosorbent assay KW - multiple infections KW - neuropathy KW - parasitic worms KW - pork tapeworm KW - postmortem inspections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802266&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. AU - Corti, M. C. AU - Guralnik, J. M. AU - Salive, M. E. AU - Harris, T. AU - Ferrucci, L. AU - Glynn, R. J. AU - Havlik, R. J. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1997/// VL - 126 IS - 10 SP - 753 EP - 760 SN - 0003-4819 AD - Corti, M. C.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA. N1 - Accession Number: 19981402534. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - A multicentre, longitudinal study with a 5 year follow up to death was carried out to determine whether total cholesterol level is a risk factor for coronary heart disease (CHD) in older adults or inadequate adjustment for co-occurring diseases. 4066 men and women from East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven, Connecticut were included. In 1988, subjects were interviewed about health status and blood samples were taken. Mortality was followed-up to 1992. Analyses included all fatal CHD events (252 deaths) and did not adjust for risk factors for CHD and measures of frailty. Subjects with the lowest total cholesterol levels (≤4.15 mmol/litre) had the highest rate of death from CHD, whereas those with elevated total cholesterol levels (≥6.20 mmol/litre) had a lower risk for death from CHD (P for trend=0.04). After adjustment for established risk factors for CHD and markers of poor health (including chronic conditions, low serum iron and albumin levels) and exclusion of 44 deaths from CHD occurring in the first year, elevated total cholesterol levels predicted increased risk for death from CHD and the risk for death from CHD decreased as cholesterol levels decreased (P for trend =0.005). It is concluded that elevated total cholesterol level is a risk factor for death from CHD in older adults, and the apparent adverse effects associated with low cholesterol levels are secondary to comorbidity and frailty. This suggests that excluding older persons from cholesterol screening is inappropriate, but interpretation of results in older persons requires clinical judgment. KW - cardiovascular diseases KW - causes of death KW - cholesterol KW - heart diseases KW - hypercholesterolaemia KW - hypocholesterolaemia KW - mortality KW - Connecticut KW - Iowa KW - Massachusetts KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Corn Belt States of USA KW - North Central States of USA KW - West North Central States of USA KW - coronary diseases KW - death rate KW - hypercholesterinemia KW - hypercholesterolemia KW - hypocholesterolemia KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402534&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Crystalluria and urinary tract abnormalities associated with indinavir. AU - Kopp, J. B. AU - Miller, K. D. AU - Mican, J. A. M. AU - Feuerstein, I. M. AU - Vaughan, E. AU - Baker, C. AU - Pannell, L. K. AU - Falloon, J. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1997/// VL - 127 IS - 2 SP - 119 EP - 125 SN - 0003-4819 AD - Kopp, J. B.: Building 10, Rm 3N116, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006840. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 150378-17-9. N2 - Of 240 patients receiving indinavir, 142 provided urine specimens for analysis. 29 (20%) had crystals consisting of plate-like rectangles and fan-shaped or starburst forms. Mass spectrometry and HPLC confirmed that these crystals were composed of indinavir. Of 40 patients who were not receiving indinavir, none had similar crystals (P<0.001). 19 of the 240 patients receiving indinavir (8%) developed urologic symptoms. Of these, 7 (3%) had nephrolithiasis and the other 12 (5%) had previously undescribed syndromes: crystalluria associated with dysuria and crystalluria associated with back or flank pain. 4 of the patients with the latter syndrome had radiographic evidence of intrarenal sludging. It is concluded that indinavir forms characteristic crystals in the urine. This crystalluria may be associated with dysuria and urinary frequency, with flank or back pain associated with intrarenal sludging, and with the classic syndrome of renal colic.Editorial Comment:This study defines the urinary tract problems associated with the use of Indinavir. These problems affect up to 12% of the patients taking this drug (if you include the patients described in an added 'Note in proof' in this paper). This very interesting article also describes, and shows beautiful photographs of indinavir crystals in the urine; the latest addition to the collection of urine sediments that medical students will have to learn in the future. KW - abnormalities KW - adverse effects KW - antiviral agents KW - drug therapy KW - HPLC KW - human diseases KW - indinavir KW - kidneys KW - patients KW - students KW - treatment KW - urinary tract KW - urine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - chemotherapy KW - high performance liquid chromatography KW - syndromes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006840&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Significance of sarcopenia in the elderly. AU - Chhanda Dutta A2 - Beck, M. A. et al. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1997/// VL - 127 IS - 5SUPPL SP - 992 EP - 992 SN - 0022-3166 AD - Chhanda Dutta: Geriatrics Program, National Institute of Aging, Bethesda, MD 20893, USA. N1 - Accession Number: 19971408867. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition N2 - This article briefly reviews the public health effect of sarcopenia and discusses future research possibilities. KW - body composition KW - losses KW - old age KW - public health KW - reviews KW - skeletal muscle KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Society for Nutritional Sciences annual meeting KW - sarcopenia KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408867&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New nonpurified diet (NTP-2000) for rodents in the national toxicology program's toxicology and carcinogenesis studies. AU - Rao, G. N. A2 - Beck, M. A. et al. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1997/// VL - 127 IS - 5SUPPL SP - 842S EP - 846S SN - 0022-3166 AD - Rao, G. N.: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19971408503. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 22 ref. Registry Number: 7440-70-2, 7723-14-0. Subject Subsets: Human Nutrition; Animal Nutrition N2 - This article presents a summary of the results from a series of studies that formulated several experimental diets and used them to examine the influence of dietary protein, fat and fibre on chronic diseases and tumour incidences in rats. Based on the results of the experimental diets, an open-formula non-purified diet designated as NTP-2000 was designed; the formulation and composition of this diet is described. The results of a 13-week study comparing the diets NIH-07 and NTP-2000 are also presented. Generally, the NTP-2000 diet was adequate for growth, did not affect the haematological parameters and did not cause substantial changes in blood chemistry, serum enzyme or serum electrolyte values. The NTP-2000 diet decreased liver and kidney weights, prevented nephrocalcinosis and decreased the severity of diet- and possible age-associated lesions. KW - calcium KW - carcinogenesis KW - composition KW - diets KW - evaluation KW - fat KW - fats KW - fibre KW - growth KW - lesions KW - minerals KW - neoplasms KW - phosphorus KW - proteins KW - toxicology KW - rats KW - rodents KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ain-2000 KW - American Society for Nutritional Sciences annual meeting KW - cancers KW - fiber KW - Feed Composition and Quality (RR300) KW - Human Nutrition (General) (VV100) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408503&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anthropometry and breast cancer. AU - Ziegler, R. G. A2 - Beck, M. A. et al. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1997/// VL - 127 IS - 5SUPPL SP - 924S EP - 928S SN - 0022-3166 AD - Ziegler, R. G.: Nutritional Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971408659. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition N2 - Studies that examine the relationship between measurements of body size and shape (including height, adiposity, weight change and fat deposition patterns) and breast cancer risk are reviewed. KW - abdominal fat KW - adipose tissue KW - anthropometric dimensions KW - body fat KW - body weight KW - energy balance KW - energy intake KW - height KW - mammary gland neoplasms KW - obesity KW - physical activity KW - reviews KW - risk KW - weight gain KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Society for Nutritional Sciences annual meeting KW - anthropometric measurements KW - fatness KW - mammary tumour KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408659&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Perspectives on integrating experimental and epidemiologic research on diet, anthropometry and breast cancer. AU - Ballard-Barbash, R. AU - Birt, D. F. AU - Kestin, M. AU - King, I. B. A2 - Beck, M. A. et al. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1997/// VL - 127 IS - 5SUPPL SP - 936S EP - 939S SN - 0022-3166 AD - Ballard-Barbash, R.: Applied Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19971408662. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Three perspectives on the integration of experimental and epidemiological research on diet, anthropometry and breast cancer are presented: integration of basic, clinical and epidemiological research on anthropometry and breast cancer; limitations and synergy of epidemiological and experimental approaches; and controlled dietary interventions and intermediate endpoints. Possible future improvements in animal models are also discussed. KW - adipose tissue KW - animal experiments KW - animal models KW - anthropometric dimensions KW - body weight KW - carcinogenesis KW - diet KW - dietary fat KW - energy intake KW - epidemiology KW - genetically engineered organisms KW - height KW - mammary gland neoplasms KW - research KW - transgenic animals KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Society for Nutritional Sciences annual meeting KW - animal research KW - anthropometric measurements KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - mammary tumour KW - source fat KW - studies KW - transgenic organisms KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Muscle mass and strength: relation to function in population studies. AU - Harris, T. A2 - Beck, M. A. et al. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1997/// VL - 127 IS - 5SUPPL SP - 1004S EP - 1006S SN - 0022-3166 AD - Harris, T.: National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971408872. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - This article briefly reviews longitudinal population studies that examined the relationship between sarcopenia and muscle function over time. KW - age KW - mass KW - men KW - old age KW - reviews KW - sex differences KW - skeletal muscle KW - strength KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - American Society for Nutritional Sciences annual meeting KW - Human Nutrition (General) (VV100) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408872&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low levels of physical activity in 5-year-old children. AU - Salbe, A. D. AU - Fontvieille, A. M. AU - Harper, I. T. AU - Ravussin, E. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1997/// VL - 131 IS - 3 SP - 423 EP - 429 SN - 0022-3476 AD - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. N1 - Accession Number: 19981401028. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - Physical activity levels were investigated in 43 white and 84 Pima Indian children aged 5 years at the National Institute of Diabetes and Digestive and Kidney Diseases in Phoenix, Arizona and the National Institutes of Health Field Clinic in Sacaton, Arizona, USA, from summer 1991-1995. Pima Indian children (mean age 5.5 years) had significantly higher body weight (23 vs. 19.1 kg), body mass index, relative weight, percentage body fat (30 vs. 21%), fat mass and anthropometric dimensions than white children (mean age 5.4 years). There were no significant differences in total energy expenditure (TEE) and resting metabolic rate (RMR) between the 2 groups. Percentage body fat was negatively correlated with the number of past year recreational activities and parental activity rating. White and Pima Indian children had physical activity levels (TEE/RMR) of 1.35, significantly lower than the WHO recommendation (1.7-2.0) and a TEE value 25% lower than WHO recommendation for dietary intake (67 kcal/kg per day). It is concluded that the cause of obesity in Pima Indian children is most likely due to increased dietary intake, probably in the form of high-fat foods. KW - anthropometric dimensions KW - body fat KW - body weight KW - children KW - energy exchange KW - ethnic groups KW - physical activity KW - resting energy exchange KW - Arizona KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mountain States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southwestern States of USA KW - anthropometric measurements KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401028&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A developmental defect in Plasmodium falciparum male gametogenesis. AU - Guinet, F. AU - Dvorak, J. A. AU - Fujioka, H. AU - Keister, D. B. AU - Muratova, O. AU - Kaslow, D. C. AU - Aikawa, M. AU - Vaidya, A. B. AU - Wellems, T. E. JO - Journal of Cell Biology JF - Journal of Cell Biology Y1 - 1997/// VL - 135 IS - 1 SP - 269 EP - 278 SN - 0021-9525 AD - Guinet, F.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970805868. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Protozoology N2 - A defect is described that affects the development of competent male gametocytes from a mutant clone of Plasmodium falciparum (Dd2). Comparison of the Dd2 clone with the predecessor clone from which it was derived (W2′82) showed that the defect is a mutation that arose during the long-term cultivation of asexual stages in vitro. Light and electron microscopic images, and indirect immunofluorescence assays with male-specific anti-α-tubulin II antibodies, indicated a global disruption of male development at the gametocyte level, with at least a 70-90% reduction in the proportion of mature male gametocytes by the Dd2 clone relative to W2′82. A high prevalence of abnormal gametocyte forms, frequently containing multiple and unusually large vacuoles, was associated with the defect. It is suggested that the reduced production of mature male gametocytes may reflect a problem in processes that commit a gametocyte to male development or a progressive attrition of viable male gametocytes during maturation. The defect is genetically linked to an almost complete absence of male gamete production and of infectivity to mosquitoes. This is the first sex-specific developmental mutation identified and characterized in Plasmodium. KW - clones KW - development KW - gametocytes KW - gametogenesis KW - human diseases KW - malaria KW - mutations KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970805868&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Insulin stimulates both leptin secretion and production by rat white adipose tissue. AU - Barr, V. A. AU - Malide, D. AU - Zarnowski, M. J. AU - Taylor, S. I. AU - Cushman, S. W. JO - Endocrinology (Philadelphia) JF - Endocrinology (Philadelphia) Y1 - 1997/// VL - 138 IS - 10 SP - 4463 EP - 4472 SN - 0013-7227 AD - Barr, V. A.: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892-1829, USA. N1 - Accession Number: 19981404402. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9004-10-8, 169494-85-3. Subject Subsets: Human Nutrition KW - adipocytes KW - adipose tissue KW - in vitro KW - insulin KW - leptin KW - production KW - secretion KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fat cells KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Five complete genomes of JC virus Type 3 from Africans and African Americans. AU - Agostini, H. T. AU - Ryschkewitsch, C. F. AU - Brubaker, G. R. AU - Shao, J. AU - Stoner, G. L. JO - Archives of Virology JF - Archives of Virology Y1 - 1997/// VL - 142 IS - 4 SP - 637 EP - 655 SN - 0304-8608 AD - Agostini, H. T.: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-4126, USA. N1 - Accession Number: 19972006681. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Tropical Diseases N2 - The complete sequence of 5 human polyomavirus JC virus (JCV) Type 3 strains is reported. The entire JCV genome was polymerase chain reaction amplified from urine specimens of 3 African and 2 African-American individuals. The African consensus sequence was compared with the Type 1 and Type 2 prototype strains, JCV (Mad-1) and JCV(GS/B), respectively. Type 3 differed in 2.2% of its coding region genome from JCV (Mad-1) and in 1.3% from JCV(GS/B). Within the coding region the sequence variation among the 3 types was higher in the capsid protein VP1 and in the regulatory protein large T antigen than in the agnoprotein or in VP2/3. Notable Type 3-specific changes were located at sites adjacent to the zinc finger motif and near the major donor and acceptor splice junctions of large T antigen. Four of the 5 urinary Type 3 strains had an unrearranged, archetypal regulatory region. African strain #309 showed a 10-bp deletion at a location similar to that previously described for #307 from Tanzania. The African-American Type 3 strain #312 was closely related to the African consensus sequence. The complete genome of a urinary JCV strain from another African-American male, previously reported as a possible Type 5, showed a sequence difference of only 0.52% from the Tanzanian consensus and was reclassified as a subtype of Type 3. KW - DNA binding motifs KW - ethnic groups KW - genes KW - genomes KW - nucleotide sequences KW - progressive multifocal leukoencephalopathy KW - proteins KW - strains KW - JC polyomavirus KW - man KW - Polyomavirus KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - DNA sequences KW - jc virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006681&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rabies viruses infect primary cultures of murine, feline, and human microglia and astrocytes. AU - Ray, N. B. AU - Power, C. AU - Lynch, W. P. AU - Ewalt, L. C. AU - Lodmell, D. L. JO - Archives of Virology JF - Archives of Virology Y1 - 1997/// VL - 142 IS - 5 SP - 1011 EP - 1019 SN - 0304-8608 AD - Ray, N. B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, MT 59840, USA. N1 - Accession Number: 19972209052. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - Primary cultures of murine, feline, and human microglia and astrocytes were infected with different rabies viruses: 2 unpassaged street virus isolates, a cell culture-adapted strain, and a mouse brain-passaged strain. Infection was detected by immunofluorescence in 15 of the 16 (94%) virus-glial cell combinations. Replication of infectious virus, determined by infectivity assay, was detected in 7 of 8 (88%) virus-cell combinations. These results show that astrocytes and microglia can be infected by rabies viruses, suggesting that they may have a role in disease, perhaps contributing to viral spread, persistence and/or neuronal dysfunction. KW - cell culture KW - immunofluorescence KW - nervous system KW - viral diseases KW - cats KW - man KW - mice KW - rabies virus KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Muridae KW - rodents KW - Lyssavirus KW - Rhabdoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - astrocytes KW - fluorescent antibody technique KW - IFAT KW - microglia KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Tissue and Cell Culture (LL700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972209052&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intake of Vitamins E, C, and A and risk of lung cancer. The NHANES I Epidemiologic Followup Study. AU - Yong LeeChen AU - Brown, C. C. AU - Schatzkin, A. AU - Dresser, C. M. AU - Slesinski, M. J. AU - Cox, C. S. AU - Taylor, P. R. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1997/// VL - 146 IS - 3 SP - 231 EP - 243 SN - 0002-9262 AD - Yong LeeChen: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19971412974. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 68-26-8, 1406-18-4, 50-81-7. Subject Subsets: Human Nutrition N2 - The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-h recall) and lung cancer incidence was studied in the First National Health and Nutrition Examination Survey Epidemiologic Followup Study cohort of 3968 men and 6100 women, aged 25-74 years. During a median follow-up period of 19 years (from 1971-1975 to 1992), 248 persons developed lung cancer. Adjusted for potential confounders using Cox proportional hazards regression methods with age as the underlying time variable, the relative risk of lung cancer for subjects in the highest quartile of vitamin C intake compared with those in the lowest quartile was 0.66 (95% confidence interval (CI) 0.45-0.96). For vitamin A intake, a protective effect was observed only for its fruit and vegetable component (carotenoids) among current smokers (relative risk = 0.49, 95% CI 0.29-0.84), but this was modified by the intensity of smoking (a significant effect (relative risk = 0.33, 95% CI 0.13-0.84) was observed only for those in the lowest tertile of pack-years of smoking). The vitamin E intake-lung cancer relation was modified by the intensity of smoking with a significant protective effect confined to current smokers in the lowest tertile of pack-years of smoking (relative risk = 0.36, 95% CI 0.16-0.83). There was no additional protective effect of vitamin E, C, and A supplements beyond that provided through dietary intake. When vitamin E, vitamin C, and carotenoid intakes were examined in combination, a strong protective effect was observed for those in the highest quartile compared with those in the lowest quartile of all 3intakes (relative risk = 0.32, 95% CI 0.14-0.74). These data provide support for a protective role of vitamins E and C and of carotenoids against lung cancer risk but with a modification in effects by the intensity of cigarette exposure. While smoking avoidance is the most important behaviour to reduce lung cancer risk, the daily consumption of a variety of fruits and vegetables that provide a combination of these nutrients and other potential protective factors may offer the best dietary protection against lung cancer. KW - ascorbic acid KW - carcinogenesis KW - carotenoids KW - fruit KW - intake KW - lung cancer KW - lungs KW - neoplasms KW - retinol KW - risk KW - tobacco smoking KW - tocopherols KW - vegetables KW - vitamin E KW - vitamins KW - Maryland KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - tetraterpenoids KW - United States of America KW - vegetable crops KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Insulin and endometrial cancer. AU - Troisi, R. AU - Paotischman, N. AU - Hoover, R. N. AU - Siiteri, P. AU - Brinton, L. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1997/// VL - 146 IS - 6 SP - 476 EP - 482 SN - 0002-9262 AD - Troisi, R.: Environmental Epidemiology Branch, National Cancer Institute, EPN Room 443, 6130 Executive Blvd., Bethesda, MD 70892-7374, USA. N1 - Accession Number: 19972010387. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 59112-80-0, 50-28-2, 53-16-7, 9004-10-8. Subject Subsets: Human Nutrition; Public Health N2 - Circulating sex hormones and fasting C-peptide levels were measured in sera obtained from 165 postmenopausal endometrial cancer cases in the USA accrued between 1 June 1987 and 15 May 1990, from hospitals in Chicago, Illinois; Hershey, Pennsylvania; Irvine and Long Beach, California; Minneapolis, Minnesota; and Winston-Salem, North Carolina, and 180 community and hysterectomy controls. Women with a personal history of diabetes were excluded. Among controls, C-peptide was positively correlated with body mass index (BMI) (r = 0.44), waist-to-thigh circumference ratio (r = 0.24), oestrone (r = 0.18), and oestradiol (r = 0.28) (albumin-bound (r = 0.45), and free (r = 0.37)) and negatively correlated with sex hormone-binding globulin (r = -0.48). In age-adjusted analyses, the odds ratios and 95% confidence intervals for tertiles of C-peptide and endometrial cancer were, from lowest to highest: 1.0 (reference), 0.78 (95% confidence interval (CI) 0.43-1.4), and 2.2 (95% CI 1.3-3.7). Further adjustment for BMI substantially attenuated the odds ratios for the highest tertile of C-peptide (odds ratio = 1.2, 95% CI 0.63-2.1), and adjustment for body mass index and other risk factors for endometrial cancer eliminated the association (odds ratio = 1.0, 95% CI 0.55-2.0). In contrast, adjustment for C-peptide had little influence on the magnitude of the positive associations between body mass index (odds ratio for highest vs. lowest tertile, without and with adjustment for C-peptide = 4.1 (95% CI 2.3-7.5) and 3.7 (95% CI 1.9-7.1), respectively) or several steroid hormones and endometrial cancer. These data are not consistent with the hypothesis that the effect of obesity on endometrial cancer risk is mediated through high insulin levels. KW - C-peptide KW - diabetes KW - effects KW - endometrial cancer KW - estradiol KW - estrone KW - human diseases KW - hyperinsulinism KW - insulin KW - neoplasms KW - obesity KW - risk factors KW - sex hormones KW - steroids KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - fatness KW - oestradiol KW - oestrol KW - oestrone KW - proinsulin C-peptide KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010387&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of measurement error on energy-adjustment models in nutritional epidemiology. AU - Kipnis, V. AU - Freedman, L. S. AU - Brown, C. C. AU - Hartman, A. M. AU - Schatzkin, A. AU - Wacholder, S. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1997/// VL - 146 IS - 10 SP - 842 EP - 855 SN - 0002-9262 AD - Kipnis, V.: Biometry Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 344, 6130 Executive Blvd., MSC 7354, Bethesda, MD 20892-7354, USA. N1 - Accession Number: 19981408254. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition N2 - Contrary to conventional assumptions invoked in the standard treatment of the effect of measurement error in regression analysis, reporting errors in dietary studies are usually biased, correlated with true nutrient intakes and with each other, heteroscedastic and nonnormally distributed. Methods developed in this paper allow for this more complex error structure and are therefore more appropriate for dietary data. For practical illustration, these methods were applied to data from the Women's Health Trial Vanguard Study. The results demonstrate considerable shrinkage in the magnitude of the estimated main exposure effect in energy-adjustment models due to attenuation of the true effect and contamination from the effect of an adjusting covariate. In most cases, this shrinkage causes a sharply reduced statistical power of the corresponding significance test in comparison with measurement without error. These results emphasize the need to understand the measurement error properties of dietary instruments through validation/calibration studies and, where possible, to correct for the impact of measurement error when applying energy-adjustment models. KW - diet study techniques KW - energy intake KW - epidemiology KW - measurement KW - models KW - nutrition research KW - regression analysis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - metrology KW - Diet Studies (VV110) KW - Techniques and Methodology (ZZ900) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408254&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Degenerate MHC restriction reveals the contribution of Class I MHC molecules in determining the fine specificity of CTL recognition of an immunodominant determinant of HIV-1 gp160 V3 loop. AU - Shirai, M. AU - Kozlowski, S. AU - Margulies, D. H. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 158 IS - 7 SP - 3181 EP - 3188 SN - 0022-1767 AD - Shirai, M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1578, USA. N1 - Accession Number: 19972004039. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - Three class I MHC molecules that are distinct in sequence and serology surprisingly cross-present the same HIV-1 peptide to T cells of each of the other haplotypes. This MHC restriction degeneracy is representative of the bulk of the CTL population with this specificity. Taking advantage of this degeneracy, it was possible to examine the influence that the presenting class I MHC molecule has on the fine specificity of response of a single CTL with a single TCR, as had been done previously for class II-restricted responses in the degenerate cytochrome c system. Reciprocal differences were found that indicate that different class I MHC molecules impose an apparently different fine specificity on the same TCR of a CTL, emphasizing the concerted role of both receptors in the determining the specificity of the CTL recognition event. KW - antigens KW - envelope protein gp160 KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - major histocompatibility complex KW - responses KW - serology KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - antigenicity KW - gp160 KW - histocompatibility complex KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunogens KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004039&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Borrelia burgdorferi activates nuclear factor-κB and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts. AU - Ebnet, K. AU - Brown, K. D. AU - Siebenlist, U. K. AU - Simon, M. M. AU - Shaw, S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 158 IS - 7 SP - 3285 EP - 3292 SN - 0022-1767 AD - Ebnet, K.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970504484. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9008-11-1, 142298-00-8. Subject Subsets: Medical & Veterinary Entomology N2 - The potential of B. burgdorferi to induce gene expression of chemokines and adhesion molecules in human endothelial cells, keratinocytes and fibroblasts was analysed. Induction of the chemokines RANTES (regulated upon activation, normal T cells expressed and secreted), monocyte chemoattractant protein-1, interleukin-8, gro-α, IFN-inducible protein-10, and mig (monokine induced by γ-IFN), and of the adhesion molecules E-selectin, ICAM-1 and VCAM-1 in endothelial cells and induction of the same chemokines and ICAM-1 in fibroblasts was found. This is mediated by the lipid moiety of the outer surface lipoprotein A. Induction of chemokine and adhesion molecule genes by B. burgdorferi occurs rapidly and does not require new protein synthesis. Induction is blocked by inhibitors of nuclear factor (NF)-κB. Also, B. burgdorferi induces nuclear translocation of NF-κB and a transient increase in the expression of its inhibitor IκB-α. These findings indicate that B. burgdorferi is a potent inducer of molecules required for leukocyte recruitment to inflammatory foci, and the data suggest that this biological activity is due to the ability of the spirochaetes to activate the pleiotropic transcription factor NF-κB. KW - cells KW - chemokines KW - cytokines KW - endothelium KW - fibroblasts KW - gene expression KW - human diseases KW - immune response KW - immunopathology KW - inflammation KW - interferon KW - interleukin 8 KW - interleukins KW - leukocytes KW - lipids KW - lipoproteins KW - Lyme disease KW - surface proteins KW - T lymphocytes KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adhesion molecules KW - bacterium KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - leucocytes KW - lipins KW - lyme borreliosis KW - membrane proteins KW - outer surface proteins KW - T cells KW - white blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504484&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nuclear factor-κB potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection. AU - Moriuchi, H. AU - Moriuchi, M. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 158 IS - 7 SP - 3483 EP - 3491 SN - 0022-1767 AD - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004040. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 62-38-4. N2 - To investigate the molecular mechanisms of RANTES expression, the RANTES promoter region was analysed by transient expression and gel-mobility shift assays. It was demonstrated that: (1) RANTES promoter activity is upregulated by PMA plus ionomycin, coexpression of the p65 subunit of nuclear factor (NF)-κB, the proinflammatory cytokines TNF-α and IL-1β, and the CD28 costimulatory pathway; (2) the RANTES promoter region contains 4 NF-κB binding sites at positions -30, -44, -213 and -579 relative to the transcription start site; (3) one site (-213) is an NF-AT (nuclear factor of activated T cells) binding site that also has weak affinity to NF-κB, and the most distal site (-579) also serves as a CD28-responsive element; and (4) mutation on any of those NF-κB sites of coexpression of IκBα (cytoplasmic inhibitor of NF-κB) markedly reduced the promoter activity. Thus, NF-κB, a potent transcriptional activator of HIV expression, is also involved in the expression of RANTES, a chemokine that blocks infection by macrophage-tropic strains of HIV. KW - cytokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - infection KW - mutations KW - phenylmercury acetate KW - promoters KW - strains KW - transcription KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - DNA transcription KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - PMA KW - promoter region KW - promoter sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vaccine-specific antibody responses induced by HIV-1 envelope subunit vaccines. AU - Pincus, S. H. AU - Messer, K. G. AU - Cole, R. AU - Ireland, R. AU - VanCott, T. C. AU - Pinter, A. AU - Schwartz, D. H. AU - Graham, B. S. AU - Gorse, G. J. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 158 IS - 7 SP - 3511 EP - 3520 SN - 0022-1767 AD - Pincus, S. H.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19972004042. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - The first generation of candidate vaccines to prevent HIV infection consisted of recombinant envelope proteins (Env, gp120 and gp160) derived from a single laboratory strain of HIV, designated IIIB/LAV, but produced with different expression systems. This study examined the fine specificity of the human Ab response to each vaccine and compared them to the response of laboratory workers infected with the same strain of HIV. The best responders from each vaccine protocol were studied and compared. Detailed comparisons of the fine specificity of the Ab response were possible because all immunological assays were performed using homologous recombinant proteins, peptides and virus stocks. Although the total amounts of anti-Env Ab were comparable, the groups exhibited significant differences in epitope specificity, avidity and functional capacity of the Ab response. The data demonstrate that the form of the immunogen (e.g., live virus or recombinant protein) is important in determining the quality of the Ab response. Conclusions are also drawn regarding characteristics of there anti-HIV-neutralizing Ab response. These studies represent one of the most detailed analyses of the human Ab response to any Ag and have implications for the development of vaccines for HIV as well as for other microbial pathogens. KW - antibodies KW - antibody formation KW - envelope proteins KW - epitopes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - infection KW - laboratories KW - laboratory workers KW - proteins KW - responses KW - vaccines KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004042&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs. AU - Ahlers, J. D. AU - Dunlop, N. AU - Alling, D. W. AU - Nara, P. L. AU - Berzofsky, J. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 158 IS - 8 SP - 3947 EP - 3958 SN - 0022-1767 AD - Ahlers, J. D.: Correspondence address [Berzofsky, J. A.]: Molecular Immunogenetics and Vaccine Research Section Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004699. Publication Type: Journal Article. Language: English. Number of References: 80 ref. Registry Number: 9007-49-2. N2 - The effects were studied of IL-2, IL-4, IL-7, IL-1β, IL-12, IFN-γ, TNF-α and granulocyte-macrophage colony-stimulating factor (GM-CSF) incorporated with peptide in adjuvant on a variety of responses elicited: cytotoxic T lymphocytes, T-cell proliferation, cytokine production and message, and antibody isotype, were investigated. GM-CSF was the single most effective cytokine for enhancing both cellular and humoral immunity to 2 previously characterized HIV-1MN vaccine constructs. Novel synergies were also detected. GM-CSF synergized with IL-12 for CTL induction in BALB/c mice concomitant with suppression of Th2 cytokines IL-4 and IL-10. TNF-α also synergized with IL-12, but by a different mechanism, inducing IFN-γ production in BALB/c mice and thus shifting the response to a Th1 phenotype. The results suggested that in addition to IL-2, optimum induction of CD8+ CTL in vivo requires a combination of cytokines, including GM-CSF (probably acting to enhance Ag presentation and CD4+ cell help), and IL-12 (steering the Th response toward Th1 cytokines). Editorial Comment: This paper explores the ability of several cytokines to augment and steer the immune response in different directions. Several recent papers have explored the use of IL-12 to augment specifically a Th1/CTL response [Tsuji, et al. Journal of Immunology (1997) 158, 4008, 1997]. In this study, Ahlers et al. perform an extensive survey using peptide immunization of mice combined with injection of IL-2, IL-4, IL-7, IL-1β, IL-12, IFN-γ, TNF-α and GM-CSF. GM-CSF was the most useful cytokine for enhancing both antibody and cellular responses. Optimal CTL induction was achieved by using both GM-CSF and IL-12. The authors speculate that GM-CSF enhances antigen presentation and IL-12 steers the CD4 response to a Th1 phenotype. It will be interesting to see these results extended to use in DNA vaccine models. KW - adjuvants KW - antibodies KW - antigens KW - CD4 antigens KW - cytokines KW - DNA KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - humoral immunity KW - immune response KW - immunity KW - immunization KW - immunology KW - injection KW - phenotypes KW - production KW - responses KW - T lymphocytes KW - vaccines KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - CD4 KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004699&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - FcεRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology. AU - Jankovic, D. AU - Kullberg, M. C. AU - Dombrowicz, D. AU - Barbieri, S. AU - Caspar, P. AU - Wynn, T. A. AU - Paul, W. E. AU - Cheever, A. W. AU - Kinet, J. P. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 4 SP - 1868 EP - 1875 SN - 0022-1767 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19970804917. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 37341-29-0, 308067-57-4, 207137-56-2. Subject Subsets: Helminthology; Tropical Diseases N2 - The IgE/FcεRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by FcεRI+ non-B, non-T (NBNT) cells. To evaluate the role of IgE/FcεRI signalling in the host response to helminths, Schistosoma mansoni infection was studied in FcεRI knockout (KO) mice. Infected wild-type (wt) and KO animals showed comparable adult worm and tissue egg burdens, arguing against a role for FcεRI interactions in host resistance. Significantly, NBNT cells from infected KO, in contrast to wt animals, did not secrete IL-4 when stimulated with anti-IgE antibody or soluble parasite antigen. Nevertheless, serum IgE levels and Th2 cytokine production profiles were comparable in both strains of mice, demonstrating that the antigen-dependent stimulation of IL-4 secretion by NBNT cells is not essential for helminth-induced Th2 differentiation. However, when stimulated with low antigen doses, splenocytes from infected FcεRI-deficient mice produced less IL-4 in vitro than similar cultures from infected wt animals, an effect attributable to their defective NBNT cell function. Moreover, infected KO mice showed enhanced egg granuloma formation and hepatic fibrosis, revealing that the IgE/FcεRI interaction, while not essential for Th2 response development or resistance to primary infection, plays a significant role in down-regulating host pathology. KW - cytokines KW - experimental infections KW - helminths KW - human diseases KW - IgE KW - immune response KW - immunity KW - immunoglobulins KW - interleukin 4 KW - laboratory animals KW - liver KW - parasites KW - pathology KW - receptors KW - schistosomiasis KW - t lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bilharzia KW - bilharziasis KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - reagin KW - reaginic antibodies KW - schistosomosis KW - Strigeida KW - T cells KW - T helper cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970804917&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. AU - Denkers, E. Y. AU - Yap, G. AU - Scharton-Kersten, T. AU - Charest, H. AU - Butcher, B. A. AU - Caspar, P. AU - Heiny, S. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 4 SP - 1903 EP - 1908 SN - 0022-1767 AD - Denkers, E. Y.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980800050. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - Resistance of perforin knockout (PKO) mice to infection with Toxoplasma gondii was assessed in models of acute infection and during chronic disease. PKO mice vaccinated with the attenuated mutant, ts-4, displayed severely defective cytotoxic T lymphocyte (CTL) responses against tachyzoite-infected targets. Lysis of the natural killer (NK) target, YAC-1, was also severely impaired in PKO mice following ts-4 vaccination. In contrast, wild-type mice developed high levels of CTL and NK lytic activity after ts-4 vaccination. Despite severely defective lytic activity, vaccinated PKO animals were completely resistant to challenge with the virulent strain RH, which normally causes a lethal acute infection. Resistance was attributable to production of IFN-γ, which remained unimpaired in the PKO animals. In contrast, when PKO mice were infected with low virulence parasite strain ME49, which progresses to the cyst-forming stage after passage through an acute phase, accelerated mortality was observed beginning at 75 days pi. A 3- to 4-fold increase in brain cyst numbers was also found by day 30 in infected PKO animals. Nevertheless, the PKO strain produced normal levels of IFN-γ after ME49 infection, ruling out impaired production of the latter cytokine as a cause of increased susceptibility. It is concluded that perforin-dependent cytolytic function is not required for host resistance to lethal acute infection in preimmunized animals, but that this activity contributes to the control of infection during the chronic stage. KW - acute course KW - chronic course KW - cytokines KW - cytolysis KW - cytotoxic T lymphocytes KW - disease resistance KW - experimental infections KW - immune response KW - interferon KW - laboratory animals KW - mortality KW - natural killer cells KW - parasites KW - tachyzoites KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - death rate KW - immunity reactions KW - immunological reactions KW - perforin KW - resistance to disease KW - severe course KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800050&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. AU - Biddison, W. E. AU - Kubota, R. AU - Kawanishi, T. AU - Taub, D. D. AU - Cruikshank, W. W. AU - Center, D. M. AU - Connor, E. W. AU - Utz, U. AU - Jacobson, S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 4 SP - 2018 EP - 2025 SN - 0022-1767 AD - Biddison, W. E.: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10/Room 5B-16, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008271. Publication Type: Journal Article. Language: English. Number of References: 50 ref. N2 - In this study, it was demonstrated that HAM/TSP patients have elevated levels of IFN-γ-producing CD8+ T cells in their peripheral blood, and a panel of HTLV-I peptide specific CD8+ CTL clones isolated from the peripheral blood of 3 HAM/TSP patients were analyzed for their capacity to secrete the pro-inflammatory mediators IFN-γ, TNF-α, MIP-1β, IL-16, and matrix metalloproteinases. KW - CD4+ lymphocytes KW - CD8+ lymphocytes KW - chemokines KW - cytokines KW - human diseases KW - immunology KW - T lymphocytes KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4+ cells KW - CD8+ cells KW - HTLV-BLV group KW - peripheral blood KW - T cells KW - T4 lymphocytes KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120. AU - Jankovic, D. AU - Caspar, P. AU - Zweig, M. AU - Garcia-Moll, M. AU - Showalter, S. D. AU - Vogel, F. R. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 5 SP - 2409 EP - 2417 SN - 0022-1767 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4/126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19972009693. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - In the present study the use of IL-12 was evaluated as an adjuvant for promoting both humoral and cell-mediated immunity to recombinant HIV-1 gp120, a molecule previously shown to be weakly immunogenic in mice in the absence of adjuvant. HIV envelope glycoproteins are under consideration as a component of candidate vaccines for preventing AIDS and can serve as targets for both antibody- and CTL-dependent effector mechanisms. It is shown here that IL-12 can serve as an effective adjuvant for simultaneously enhancing both humoral and type 1 cytokine responses to gp120. It appears, however, that optimal immunization in this situation depends on the route of administration of IL-12 as well as the combined formulation of the cytokine and antigen with alum. The IL-12 vaccination protocol described may have general applicability in boosting responses to weakly immunogenic protein antigen. KW - acquired immune deficiency syndrome KW - adjuvants KW - antibodies KW - antigens KW - cell mediated immunity KW - cytokines KW - envelope glycoproteins KW - glycoproteins KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - humoral immunity KW - immune response KW - immunity KW - immunization KW - immunogenetics KW - immunology KW - interleukin 12 KW - interleukins KW - responses KW - vaccination KW - vaccines KW - Human immunodeficiency virus 1 KW - mice KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - antigenicity KW - cellular immunity KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009693&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of parasite antigen-specific antibody responses in unsensitized human B cells is dependent on the presence of cytokines after T cell priming. AU - Garraud, O. AU - Perler, F. B. AU - Bradley, J. E. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 10 SP - 4793 EP - 4798 SN - 0022-1767 AD - Garraud, O.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20850, USA. N1 - Accession Number: 19980802434. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2. Subject Subsets: Helminthology N2 - Using 2 recombinant filarial protein antigens (Ov27 and OvD5B, from Onchocerca volvulus) and keyhole limpet haemocyanin, T cells from uninfected, nonatopic humans were sensitized in such a manner that they were able to provide help for the selective induction of an antigen-specific antibody response; interleukins 2 and 4 (IL-2 and IL-4) were shown to be critical for sensitizing the T cells. Once sensitized, these T cells could provide the necessary signals for B cells to produce antigen-specific antibodies on exposure to the antigens, provided that IL-4 (or in some experiments IL-2) was supplied exogenously. Primary exposure of T cells to IFN-γ, but not exposure to IL-12, prevented the antigen-sensitized T cells from helping B cells to produce specific antibodies, apart from the IgG2 isotype. These data suggest that antibody-producing B cells of a defined antigen specificity and isotype can be generated differentially after in vitro priming of human T cells by antigens, provided regulatory cytokines are also present. KW - antigens KW - B lymphocytes KW - cytokines KW - haemocyanins KW - helminths KW - immune response KW - in vitro KW - induction KW - interferon KW - interleukin 2 KW - interleukin 4 KW - interleukins KW - parasites KW - recombinant antigens KW - T lymphocytes KW - man KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - B cells KW - hemocyanins KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802434&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry. AU - Moriuchi, H. AU - Mouiuchi , M. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1997/// VL - 159 IS - 11 SP - 5441 EP - 5449 SN - 0022-1767 AD - Moriuchi, H.: National Institutes of Health, Bldg 10, Rm 6A11, 10 Center Drive, MSC-1576, Bethesda, MD 20892, USA. N1 - Accession Number: 19982000414. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9003-98-9, 9007-49-2. N2 - The chemokine receptor CCR5 is a cofactor for cellular entry of macrophage-tropic strains of HIV-1. Expression of CCR5 is restricted to T cells, macrophages, and certain cell lines; however, the mechanisms controlling its expression remain largely unknown. To delineate these mechanisms, approximately 1.0 kb of DNA from the immediate 5′ upstream region of CCR5 was cloned and characterized. CCR5 promoter activity was up-regulated by PMA, and a region spanning -417 to +61 relative to the transcription start site was sufficient for the basal and induced activity. DNase [deoxyribonuclease] I footprinting assays demonstrated several protected areas within this region, and gel shift assays determined binding sites for transcriptional factors Oct-1, Oct-2, T cell factor 1α, and GATA1. CCR5 promoter activity was also induced by IL-2 or anti-CD3 Ab, while stimulation with anti-CD28 Ab markedly reduced CD3-mediated up-regulation of the CCR5 promoter. Flow cytometry confirmed the findings at the level of cell surface expression. KW - clones KW - cofactors KW - deoxyribonuclease I KW - DNA KW - flow cytometry KW - promoters KW - stimulation KW - strains KW - T lymphocytes KW - transcription KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cell surface proteins KW - deoxyribonuclease KW - deoxyribonucleic acid KW - DNA transcription KW - DNASE KW - human immunodeficiency virus type 1 KW - mechanisms KW - promoter region KW - promoter sequences KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Symptomatic appendiceal wall thickening in an HIV-infected patient cause by interleukin-2 therapy. AU - Avila, N. A. AU - Dwyer, A. J. AU - Falloon, J. JO - American Journal of Roentgenology JF - American Journal of Roentgenology Y1 - 1997/// VL - 169 IS - 2 SP - 499 EP - 500 SN - 0361-803X AD - Avila, N. A.: Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg. 10, Rm 1C-660, 10 Center Dr., MSC 1182, Bethesda, MD 20892-1182, USA. N1 - Accession Number: 19972009678. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 102524-44-7, 85898-30-2. KW - adverse effects KW - case reports KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunomodulators KW - interleukin 2 KW - interleukins KW - symptoms KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons. AU - Davey, R. T., Jr. AU - Chaitt, D. G. AU - Piscitelli, S. C. AU - Wells, M. AU - Kovacs, J. A. AU - Walker, R. E. AU - Falloon, J. AU - Polis, M. A. AU - Metcalf, J. A. AU - Masur, H. AU - Fyfe, G. AU - Lane, H. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 175 IS - 4 SP - 781 EP - 789 SN - 0022-1899 AD - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Room 11C103, Bethesda, MD 20892-1880, USA. N1 - Accession Number: 19972004509. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 102524-44-7, 85898-30-2. N2 - The safety and efficacy were assessed of 5-day cycles of subcutaneous (sc) interleukin-2 (IL-2) every 8 weeks in HIV-1-infected outpatients with ≥200 CD4+ cells/µl. Immunological, virological, and toxicity parameters were measured in 18 patients receiving standard antiretrovirals plus 5-day courses of sc IL-2 (3-18 MIU/day) every 2 months. Systemic toxicities established the maximally tolerated dose (MTD) of IL-2 as 15 MIU/day. CD4+ cell responses appeared to correlate directly with baseline CD4+ cell counts, with several patients experiencing a dramatic rise after 3 cycles. Virus load increased only transiently in the peri-injection period. It was concluded that serial cycles of outpatient sc IL-2 can be administered safely, with an MTD of 15 MIU/day. Patients with higher baseline counts appear to have a greater CD4+ cell response to sc IL-2 therapy.Editorial Comment:IL-2 increases significantly the CD4+ cell count of patients with HIV infection at the cost of a significant toxicity. This article shows that the subcutaneous route is better tolerated than the intravenous. There is an ongoing ACTG trial (ACTG 328) that is comparing two i.v. high dose regimens and highly active antiretroviral therapy (HAART) with HAART alone, that will help define the role of high dose IL-2 as adjuvant therapy in HIV infection. KW - adjuvants KW - antiviral agents KW - CD4 antigens KW - CD4+ lymphocytes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunomodulators KW - immunotherapy KW - infection KW - interleukin 2 KW - interleukins KW - leukocyte count KW - patients KW - regimens KW - safety KW - subcutaneous injection KW - toxicity KW - treatment KW - viral load KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - CD4+ cells KW - cell count KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - outpatients KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Occupational Health and Safety (VV900) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004509&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1 infected children. AU - Mofenson, L. M. AU - Korelitz, J. AU - Meyer, W. A., III AU - Bethel, J. AU - Rich, K. AU - Pahwa, S. AU - Moye, J., Jr. AU - Nugent, R. AU - Read, J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 175 IS - 5 SP - 1029 EP - 1038 SN - 0022-1899 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19972004727. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 308067-57-4, 63231-63-0. N2 - Association of HIV-1 RNA level, CD4+ cell percentage and mortality was examined in stored sera from 254 infected children in an intravenous immunoglobulin infection prophylaxis trial. 92 children (36.2%) died (41 during the study, 51 during long-term follow-up). The geometric mean baseline HIV-1 RNA level was 104 636 copies/ml and the mean CD4+ cell percentage was 25%. Relative risk of death (RR) was 2.1 if the baseline RNA level was >100 000 copies/ml (95% CI, 2.2-4.0). If RNA levels increased after baseline, the RR was 1.8 (95% CI, 1.3-2.6) and if the CD4+ cell percentage dropped to <15%, the RR was 2.8 (95% CI, 1.6-4.9). In a multivariate model, both baseline RNA level and CD4+ cell percentage were independently associated with mortality risk. In a time-dependent model, the RR per log10 increase in HIV-1 RNA copy numbers were 2.8 (95% CI, 2.1-3.6) and per 5 percentage point decrement in CD4+ cell percentage was 1.3 (95% CI, 1.2-1.5). Both variables should be considered in decision-making regarding therapy and evaluation of antiretroviral response. KW - antiviral agents KW - CD4 antigens KW - children KW - clinical aspects KW - death KW - disease course KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunoglobulins KW - infection KW - lymphocytes KW - mortality KW - relationships KW - RNA KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - clinical picture KW - death rate KW - disease progression KW - gamma-globulins KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immune globulins KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004727&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus-specific peptide. AU - Davis, D. A. AU - Humphrey, R. W. AU - Newcomb, F. M. AU - O'Brien, T. R. AU - Goedert, J. J. AU - Straus, S. E. AU - Yarchoan, R. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 175 IS - 5 SP - 1071 EP - 1079 SN - 0022-1899 AD - Davis, D. A.: Correspondence address [Yarchoan, R.]: National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004732. Publication Type: Journal Article. Language: English. Number of References: 42 ref. N2 - In an attempt to assess KSHV/HHV-8 infection, an ELISA was developed using an 18-amino acid peptide from a putative minor capsid protein of KSHV/HHV-8 conjugated to bovine serum albumin. Overall, sera from HIV-1 positive patients with KS had a higher reactivity in the assay than did sera from HIV-1 positive patients without KS (P=0.018). Of 35 HIV-1-positive patients with KS, 60% were antibody positive, compared with 27% of 33 HIV-1-positive patients without KS. Of 30 healthy blood donors, 20% were antibody positive. The ELISA responses did not correlate with antibody titres to Epstein-Barr virus. Given the homology and antigenic relatedness between KSHV/HHV-8 and Epstein-Barr virus, serological assays involving unique KSHV/HHV-8 peptides may prove to be valuable in defining the epidemiology and clinical expression of this virus. KW - antibodies KW - blood serum KW - clinical aspects KW - ELISA KW - epidemiology KW - human diseases KW - human herpesviruses KW - immunology KW - infections KW - patients KW - peptides KW - responses KW - serology KW - Human herpesvirus 4 KW - Human immunodeficiency virus 1 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - clinical picture KW - enzyme linked immunosorbent assay KW - epstein-barr virus KW - human herpesvirus KW - human immunodeficiency virus type 1 KW - other microorganisms KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004732&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Influence of other maternal variables on the relationship between maternal virus load and mother-to-infant transmission of human immunodeficiency virus type 1. AU - Burns, D. N. AU - Landesman, S. AU - Wright, D. J. AU - Waters, D. AU - Mitchell, R. M. AU - Rubinstein, A. AU - Willoughby, A. AU - Goedert, J. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 175 IS - 5 SP - 1206 EP - 1210 SN - 0022-1899 AD - Burns, D. N.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510, USA. N1 - Accession Number: 19972004736. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 63231-63-0. N2 - To assess the relationship between HIV-1 RNA level, other important covariates, and mother-to-infant (vertical) transmission of HIV-1, third trimester repository specimens from 160 HIV-1-seropositive women enrolled in the Mothers and Infants Cohort Study during 1986-91 were assayed in batch for HIV-1 RNA. A significant association between peripheral blood HIV-1 RNA level and vertical transmission remained after controlling for CD4+ cell level, duration of ruptured membranes, "hard" drug (cocaine and heroin) use, and frequency of sexual activity during pregnancy. However, the association was attenuated among women with advanced HIV infection and those with a high frequency of sexual activity during pregnancy. In these settings, interventions that target risk factors other than virus load may be particularly important for preventing vertical transmission of HIV-1. KW - disease transmission KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - infection KW - maternal transmission KW - mothers KW - risk factors KW - RNA KW - transmission KW - women KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004736&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - JC virus (JCV) genotypes in brain tissue from patients with progressive multifocal leukoencephalopathy (PML) and in urine from controls without PML: increased frequency of JCV type 2 in PML. AU - Agostini, H. T. AU - Ryschkewitsch, C. F. AU - Mory, R. AU - Singer, E. J. AU - Stoner, G. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 176 IS - 1 SP - 1 EP - 8 SN - 0022-1899 AD - Agostini, H. T.: Correspondence address [Stoner, G. L.]: Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD 20892-4126, USA. N1 - Accession Number: 19972005929. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 59865-13-3, 9007-49-2. N2 - In this study, the control group consisted of 213 persons not infected with HIV-1 and 32 HIV-infected persons. JCV excretion in HIV-positive individuals confirmed that JCV DNA can be detected in >40% of single urine samples from persons aged >30 years. HIV-1 infection did not appear to increase the overall frequency of JCV excretion. This agrees with previously published results in which neither HIV-positive patients with low CD4+ lymphocyte counts nor multiple sclerosis patients treated with cyclosporin showed an increased frequency of JC viruria compared with immunocompetent controls. 67 probands were tested more than once for JCV excretion in their urine, and in most, the excretion status was stable. 12 persons had transient viruria, indicating that JCV excretion can be variable. It may therefore be useful to test serial samples in order to increase the probability of identifying the JCV genotype carried by a particular individual. Editorial comment:This interesting small study suggests that there may be differences in the strain of JC virus that causes PML. This might explain why there is a large number of individuals who shed JC in their urine but do not develop PML. This hypothesis should be explored further in a larger population. KW - body parts KW - brain KW - ciclosporin KW - clinical aspects KW - controls KW - DNA KW - encephalopathy KW - genotypes KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immune competence KW - infection KW - lymphocytes KW - multiple sclerosis KW - nervous system KW - patients KW - progressive multifocal leukoencephalopathy KW - samples KW - urine KW - Human immunodeficiency virus 1 KW - JC polyomavirus KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - clinical picture KW - cyclosporin KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunocompetence KW - immunological competence KW - jc virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005929&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing. AU - Shibata, R. AU - Maldarelli, F. AU - Siemon, C. AU - Matano, T. AU - Parta, M. AU - Miller, G. AU - Fredrickson, T. AU - Martin, M. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 176 IS - 2 SP - 362 EP - 373 SN - 0022-1899 AD - Shibata, R.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg. 4, Rm 305, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19972006927. Publication Type: Journal Article. Language: English. Number of References: 27 ref. N2 - Chimeric simian-HIV (SHIVs) carrying envelope glycoproteins derived from a T cell-macrophage dual-tropic primary isolate HIV-1 strain DH12 were constructed. When inoculated into macaque monkeys, SHIVMD14 carrying SIV-derived nef established significantly higher virus loads than did SHIVMD1, which contained the HIV-1 nef gene. Three patterns of CD4 cell depletion were observed in infected monkeys: exponential and irreversible loss to undetectable levels within 10 weeks of infection; marked reduction during acute infection followed by partial recovery and stabilization (lasting from 10 weeks to >1 year), with later decline to undetectable levels in some animals; and a transient loss during acute infection. The induced immunodeficiency was accompanied by CD4 cell counts of <50 cells/µl and was associated with Pneumocystis carinii pneumonia, cytomegalovirus meningoencephalitis, lymphoid depletion, and thymic atrophy. KW - acute infections KW - CD4 antigens KW - CD4+ lymphocytes KW - depletion KW - envelope glycoproteins KW - glycoproteins KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - leukocyte count KW - microbiology KW - pathogenesis KW - pathogenicity KW - Cytomegalovirus KW - Human immunodeficiency virus 1 KW - Macaca KW - monkeys KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - human immunodeficiency viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Pneumocystis KW - Pneumocystidaceae KW - CD4 KW - CD4+ cells KW - cell count KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - severe infections KW - T4 lymphocytes KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006927&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Summary of antibody workshop: the role of humoral immunity in the treatment and prevention of emerging and extant infectious diseases. AU - Krause, R. M. AU - Dimmock, N. J. AU - Morens, D. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 176 IS - 3 SP - 549 EP - 559 SN - 0022-1899 AD - Krause, R. M.: Fogarty International Center, Bldg. 16, Rm 202B, 16 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008597. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 72 ref. N2 - The role of humoral immunity in treatment and prevention was the focus of discussion at a 1966 workshop entitled, "The Role of Humoral Immunity in the Treatment and Prevention of Infectious Diseases: The In Vitro and In Vivo Processes Initiated by Antibodies that Neutralize and Destroy Infectious Agents". The cellular and molecular mechanisms of neutralization were examined in detail. It was noted that success in passive immunity has frequently been the key element in devising a successful strategy to develop a vaccine for active immunization. The workshop concluded on a cautious note of optimism that antibody-based treatment and prevention for diseases such as HIV infection, Ebola fever, and others of clinical and public health importance deserve further development and clinical trial. KW - antibodies KW - clinical aspects KW - human immunodeficiency viruses KW - humoral immunity KW - immunity KW - immunology KW - public health KW - treatment KW - vaccines KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - strategies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Health Services (UU350) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008597&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - International colloquium on ebola virus research: summary report. AU - Breman, J. G. AU - Groen, G. van der AU - Peters, C. J. AU - Heymann, D. L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 176 IS - 4 SP - 1058 EP - 1063 SN - 0022-1899 AD - Breman, J. G.: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010637. Publication Type: Journal Article; Annual report; Conference paper; Journal article. Language: English. Number of References: 43 ref. Subject Subsets: Tropical Diseases N2 - The International Colloquium on Ebola Virus Research was held at the Institute of Tropical Medicine (ITM), Antwerp, Belgium, 4-7 September 1996. The meeting was co-organized by the ITM and the National Institutes of Health (NIH), Bethesda, Maryland, with major support from the Centers for Disease Control and Prevention (CDC), Atlanta, the Commission of the European Communities (CEC), Brussels, and the World Health Organization (WHO), Geneva. A total of 180 persons involved in filovirus research and control from 30 countries participated, including 23 representatives from African countries where Ebola and Marburg virus infections have been detected. Seven themes were addressed: (1) emerging infectious diseases priorities, (2) recent Ebola virus outbreaks, with emphasis on Zaire and Gabon, (3) virology and molecular biology, (4) pathology and pathogenesis, (5) therapy and prevention, (6) natural history, including seroarchaeology, and (7) strengthening the filovirus research network. The colloquium commemorated the 20th anniversary of the first isolation, characterization, investigation, and control of Ebola virus, detected in Zaire and the Sudan in 1976. KW - human diseases KW - research KW - viral diseases KW - Ebolavirus KW - Filovirus KW - man KW - Filoviridae KW - Mononegavirales KW - negative-sense ssRNA Viruses KW - ssRNA Viruses KW - RNA Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Filovirus KW - Ebola virus KW - studies KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010637&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial. AU - Straus, S. E. AU - Wald, A. AU - Kost, R. G. AU - McKenzie, R. AU - Langenberg, A. G. M. AU - Hohman, P. AU - Lekstrom, J. AU - Cox, E. AU - Nakamura, M. AU - Sekulovich, R. AU - Izu, A. AU - Dekker, C. AU - Corey, L. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1997/// VL - 176 IS - 5 SP - 1129 EP - 1134 SN - 0022-1899 AD - Straus, S. E.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982001792. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health N2 - To determine the safety, immunogenicity, and efficacy of a recombinant herpes simplex virus type 2 glycoprotein D and B vaccine in the treatment of recurrent genital herpes, a randomized, placebo-controlled trial was held at two referral centres in Maryland and Washington, USA. Healthy patients with 4-14 recurrences per year received injections of both glycoproteins in MF59 adjuvant or of MF59 alone at 0, 2, 12, and 14 months. For 18 study months, the rate and number of recurrences, the duration and severity of the first confirmed recurrence, vaccine immunogenicity, and rates of local and systemic reactions were determined. The monthly rate of recurrences was not significantly improved, but the duration and severity of the first study outbreak was reduced significantly by vaccination. Glycoprotein-specific and neutralizing antibodies were boosted by vaccination for the duration of the study. In conclusion, this vaccine is safe and immunogenic and ameliorated an observed first postvaccination genital recurrence, but it does not reduce recurrence frequency. KW - antibodies KW - glycoproteins KW - herpes KW - herpes simplex KW - herpes simplex viruses KW - human diseases KW - human herpesviruses KW - immunization KW - immunotherapy KW - recombinant vaccines KW - relapse KW - vaccination KW - vaccines KW - Maryland KW - USA KW - Washington KW - Human herpesvirus 2 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - herpes simplex virus KW - herpes simplex virus 2 KW - Human herpesvirus KW - immune sensitization KW - recurrence of disease KW - relapses KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001792&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The bacterial nucleoid visualized by fluorescence microscopy of cells lysed within agarose: comparison of Escherichia coli and spirochetes of the genus Borrelia. AU - Hinnebusch, B. J. AU - Bendich, A. J. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1997/// VL - 179 IS - 7 SP - 2228 EP - 2237 SN - 0021-9193 AD - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19970502512. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9012-36-6, 9007-49-2. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology N2 - The nucleoids of E. coli and the spirochaetes B. burgdorferi and B. hermsii were examined by epifluorescence microscopy of bacterial cells embedded in agarose and lysed in situ with detergent and protease. The typical E. coli nucleoid was a rosette in which 20-50 long loops of DNA emanated from a dense node of DNA. The percentages of cells in a population having nucleoids with 0, 1, 2 and 3 nodes varied with growth rate and growth phase. The borrelia nucleoid, in contrast, was a loose network of DNA strands devoid of nodes. This nucleoid structure difference correlates with the unusual genome of Borrelia species, which consists primarily of linear replicons, including a 950-kb linear chromosome and linear plasmids. This method provides a simple, direct means to analyse the structure of the bacterial nucleoid. KW - agarose KW - cells KW - DNA KW - fluorescence microscopy KW - techniques KW - Borrelia KW - Borrelia burgdorferi KW - Borrelia hermsii KW - Escherichia coli KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Borrelia KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - bacterium KW - deoxyribonucleic acid KW - E. coli KW - nucleoids KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970502512&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. AU - Stevenson, B. AU - Casjens, S. AU - Vugt, R. van AU - Porcella, S. F. AU - Tilly, K. AU - Bono, J. L. AU - Rosa, P. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1997/// VL - 179 IS - 13 SP - 4285 EP - 4291 SN - 0021-9193 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 19980500338. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - The authors mapped the genes encoding the antigenic lipoproteins OspE and OspF to an ~18-kb circular plasmid in B. burgdorferi N40. Sequencing and restriction mapping revealed that this plasmid, cp18, is homologous to an 18-kb region of the cp32 circular plasmids found in the Lyme disease spirochaetes. The data showed that cp18 may have arisen from an ancestral cp32 plasmid by deletion of a 14-kb region of DNA, indicating that a significant portion of the cp32 plasmid is not essential in cis for plasmid maintenance. These findings suggest that a relatively small recombinant plasmid capable of being stably maintained in B. burgdorferi could be constructed from a cp32 plasmid. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are U83898-U83899, and additional sequences are added to U42599 and U60963. KW - antigens KW - characterization KW - DNA KW - genes KW - lipoproteins KW - molecular genetics KW - nucleotide sequences KW - plasmids KW - surface proteins KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - immunogens KW - membrane proteins KW - outer surface proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500338&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. AU - Scharton-Kersten, T. M. AU - Yap, G. AU - Magram, J. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1997/// VL - 185 IS - 7 SP - 1261 EP - 1273 SN - 0022-1007 AD - Scharton-Kersten, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980800508. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - To formally test in vivo the hypothesis that the induction by interferon-γ (IFN-γ) of reactive nitrogen intermediates is a major mechanism of host resistance to intracellular pathogens, the course of Toxoplasma gondii infection was assessed in nitric oxide synthase (iNOS)-/- mice. As expected, macrophages from these animals displayed defective microbicidal activity against the parasite in vitro. Nevertheless, in contrast to IFN-γ-/- or interleukin-12 (IL-12) p40-/- animals, iNOS-deficient mice survived acute infection and controlled parasite growth at the site of inoculation. This early resistance was ablated by neutralization of IFN-γ or IL-12 in vivo and markedly diminished by depletion of neutrophils, demonstrating the existence of previously unappreciated NO-independent mechanisms operating against the parasite during early infection. By 3-4 weeks pi, however, iNOS knockout mice did succumb to T. gondii. At that stage parasite expansion and pathology were evident in the central nervous system but not the periphery, suggesting that the protective role of nitric oxide against this intracellular infection is tissue-specific rather than systemic. KW - acute infections KW - animal diseases KW - chronic infections KW - experimental infections KW - human diseases KW - immune response KW - immunological factors KW - interferon KW - interleukin 12 KW - laboratory animals KW - laboratory mammals KW - parasites KW - toxoplasmosis KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - nitric oxide synthase KW - severe infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800508&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. AU - Palmer, L. D. AU - Weng NanPing AU - Levine, B. L. AU - June, C. H. AU - Lane, H. C. AU - Hodes, R. J. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1997/// VL - 185 IS - 7 SP - 1381 EP - 1386 SN - 0022-1007 AD - Palmer, L. D.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004651. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - To address the possible role of replicative senescence in HIV infection, telomere length, telomerase activity and in vitro replicative capacity were assessed in peripheral blood T cells from HIV+ and HIV- donors. Genetic and age-specific effects on these parameters were controlled by studying HIV-discordant pairs of monozygotic twins. Telomere terminal restriction fragment (TRF) lengths from CD4+ T cells of HIV+ donors were significantly greater than those from HIV- twins. In contrast, telomere lengths in CD8+ T cells from HIV+ donors were shorter than in HIV- donors. The in vitro replicative capacity of CD4+ cells from HIV+ donors was equivalent to that of HIV- donors in response to stimulation through T-cell receptor CD3 and CD28. Little or no telomerase activity was detected in freshly isolated CD4+ or CD8+ lymphocytes from HIV+ or HIV- donors, but was induced by in vitro stimulation of both HIV+ and HIV- donor cells. It is suggested that HIV infection is associated with alterations in the population dynamics of both CD4+ and CD8+ T cells, but the results fail to provide evidence for clonal exhaustion or replicative senescence as a mechanism underlying the decline in CD4+ T cells of HIV-infected donors. KW - age differences KW - analysis KW - donors KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - length KW - lymphocytes KW - microbiology KW - monozygotic twins KW - pathogenesis KW - populations KW - receptors KW - responses KW - stimulation KW - t lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004651&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. AU - Liao, F. AU - Alkhatib, G. AU - Peden, K. W. C. AU - Sharma, G. AU - Berger, E. A. AU - Farber, J. M. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1997/// VL - 185 IS - 10 SP - 2015 EP - 2023 SN - 0022-1007 AD - Liao, F.: National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006121. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - As part of studies on the roles of chemokines in lymphocyte biology, experiments were designed to identify novel chemokine receptors in human T cells. This report describes the molecular cloning of a cDNA for STRL33, a gene encoding a GPCR related to known chemokine receptors that is expressed in lymphoid tissues and activated T cells, and is induced in activated PBL. It is demonstrated that STRL33, in marked contrast with CXCR4 and CCR5, can function with CD4 as a cofactor for cell fusion mediated by Envs of both M-tropic and TCL-tropic strains of HIV-1 and that transfection with STRL33 significantly enhances the ability of Jurkat cells to support productive infection with HIV-1. These data suggest that STRL33 may play a role in the establishment and/or the course of HIV-1 infection. KW - CD4 antigens KW - chemokines KW - cofactors KW - complementary DNA KW - experiments KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - infection KW - lymphocytes KW - receptors KW - strains KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - CD4 KW - cDNA KW - cloning KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006121&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. AU - Gurunathan, S. AU - Sacks, D. L. AU - Brown, D. R. AU - Reiner, S. L. AU - Charest, H. AU - Glaichenhaus, N. AU - Seder, R. A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1997/// VL - 186 IS - 7 SP - 1137 EP - 1147 SN - 0022-1007 AD - Gurunathan, S.: Lymphokine Regulation Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980803818. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9007-49-2, 308067-58-5, 9008-11-1. Subject Subsets: Protozoology N2 - To determine whether DNA immunization could elicit protective immunity to Leishmania major in susceptible BALB/c mice, cDNA for the cloned Leishmania antigen LACK was inserted into a eukaryotic expression vector downstream to the cytomegalovirus promoter. Susceptible BALB/c mice were then vaccinated subcutaneously with LACK DNA and challenged with L. major promastigotes. The protective efficacy (measured by footpad swelling or the number of parasites per mg of tissue) of LACK DNA vaccination was compared with that of recombinant LACK protein with or without recombinant interleukin (rIL)-12 protein. It was found to be similar to that achieved by LACK protein and rIL-12, but much superior to that achieved by LACK protein without rIL-12. The immunity conferred by LACK DNA was durable insofar as mice challenged 5 weeks after vaccination were still protected, and the infection was controlled for at least 20 weeks after challenge. In addition, the ability of mice to control infection at sites distant to the site of vaccination suggests that systemic protection was achieved. Immunity was dose-dependent. The control of disease progression and parasitic burden in mice vaccinated with LACK DNA was associated with enhancement of antigen-specific interferon-γ (IFN-γ) and IgG production. Both the enhancement of IFN-γ production and the protective immune response induced by LACK DNA vaccination were IL-12 dependent, as shown by treating mice with a neutralizing antibody against IL-12. Unexpectedly, depletion of CD8+ T cells at the time of vaccination or infection also abolished the protective response induced by LACK DNA vaccination, suggesting a role for these cells in DNA-vaccine-induced protection against L. major. It is concluded that DNA immunization may offer an attractive alternative vaccination strategy against intracellular pathogens, as compared with conventional vaccination with antigens combined with adjuvants. KW - animal diseases KW - antigens KW - CD8+ lymphocytes KW - DNA KW - DNA vaccines KW - experimental infections KW - human diseases KW - IgG KW - immunity KW - immunization KW - interferon KW - interleukin 12 KW - laboratory animals KW - laboratory mammals KW - leishmaniasis KW - parasites KW - promastigotes KW - proteins KW - recombinant proteins KW - vaccination KW - vaccine development KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - antigenicity KW - CD8+ cells KW - deoxyribonucleic acid KW - immune sensitization KW - immunogens KW - leishmaniosis KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803818&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. AU - Reis e Sousa, C. AU - Hieny, S. AU - Scharton-Kersten, T. AU - Jankovic, D. AU - Charest, H. AU - Germain, R. N. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1997/// VL - 186 IS - 11 SP - 1819 EP - 1829 SN - 0022-1007 AD - Reis e Sousa, C.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-1872, USA. N1 - Accession Number: 19980803938. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Protozoology N2 - The early induction of interleukin (IL)-12 is a critical event in determining the development of both innate resistance and adaptive immunity to many intracellular pathogens. Previous in vitro studies have suggested that the macrophage (MΦ) is a major source of the initial IL-12 produced upon microbial stimulation and that this response promotes the differentiation of protective T helper cell 1 (Th1) CD4+ lymphocytes from precursors that are primed on antigen-bearing dendritic cells (DC). Immunolocalization experiments and flow cytometric analysis were used to show that, contrary to expectation, DC and not MΦ are the initial cells to synthesize IL-12 in the spleens of mice exposed in vivo to an extract of Toxoplasma gondii or to lipopolysaccharide, 2 well characterized microbial stimulants of this cytokine. This production of IL-12 occurs very rapidly and is independent of interferon-γ priming or of signals from T cells, such as CD40 ligand. IL-12 production by splenic DC is accompanied by an increase in number of DCs, as well as a redistribution to the T cell areas and the acquisition of markers characteristic of interdigitating dendritic cells. The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL-12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens. This model avoids the need to invoke a 3-cell interaction for Th1 differentiation and points to the DC as both a sentinel for innate recognition and the dictator of class selection in the subsequent adaptive response. KW - dendritic cells KW - experimental infections KW - immune response KW - interleukin 12 KW - laboratory animals KW - macrophages KW - parasites KW - resistance KW - T lymphocytes KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803938&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Two tandemly arrayed genes encode the (histidine) secretory acid phosphatases of Leishmania donovani. AU - Shakarian, A. M. AU - Ellis, S. L. AU - Mallinson, D. J. AU - Olafson, R. W. AU - Dwyer, D. M. JO - Gene JF - Gene Y1 - 1997/// VL - 196 IS - 1/2 SP - 127 EP - 137 SN - 0378-1119 AD - Shakarian, A. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990800807. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9001-77-8, 71-00-1. Subject Subsets: Protozoology N2 - Secretory acid phosphatase (SAcP) was purified from Leishmania donovani culture supernatants and the amino-acid sequence was obtained from both the N-terminus and a tryptic peptide fragment derived from the isolated protein. A polymerase chain reaction (PCR)-based strategy, using degenerate oligo primers designed from the amino-acid sequence data, identified 2 single-copy, tandemly arrayed open reading frames capable of encoding the L. donovani SAcP (SAcP-1, 2052 bp and SAcP-2, 2124 bp). Both SAcP-1 and -2 were shown to be actively transcribed by L. donovani promastigotes by reverse transcription and PCR amplification. The deduced amino-acid sequences of SAcP-1 and SAcP-2 showed high conservation to each other in 4 regions: a 23-amino-acid signal peptide; a catalytic domain containing several potential N-linked glycosylation sites; a Ser/Thr-rich repeat region containing multiple potential phosphorylation sites; and a common C-terminus. Within the catalytic domain, the L. donovani SAcPs possessed 2 conserved consensus sequences characteristic of histidine acid phosphatases (AcPs). Antisera to native L. donovani SAcP immunoprecipitated in vitro transcription/translation products of both SAcP-1 and SAcP-2. The data indicate that the acid phosphatase activity secreted by L. donovani promastigotes is composed of 2 (histidine) AcP isoforms that are encoded by SAcP-1 and SAcP-2, respectively. KW - acid phosphatase KW - amino acid sequences KW - enzymes KW - excretory secretory products KW - genes KW - histidine KW - molecular genetics KW - open reading frames KW - parasites KW - polymerase chain reaction KW - promastigotes KW - Leishmania donovani KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - acid phosphomonoesterase KW - biochemical genetics KW - ORFs KW - PCR KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990800807&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes. AU - Leggatt, G. R. AU - Alexander-Miller, M. A. AU - Kumar, A. M. AU - Hoffman, S. L. AU - Berzofsky, J. A. JO - Journal of Immunological Methods JF - Journal of Immunological Methods Y1 - 1997/// VL - 201 IS - 1 SP - 1 EP - 10 SN - 0022-1759 AD - Leggatt, G. R.: Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, National Institutes of Health, Bethesda, MD 20892-1578, USA. N1 - Accession Number: 19970802387. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology N2 - A simple visual assay for identifying peptides specifically recognized by cytotoxic T lymphocytes (CTL) is described, based on the discovery that CTL develop increased adhesive properties upon T cell receptor (TCR) triggering. Several murine CTL lines were shown to pellet to the bottom of a 96-well plate in the absence of peptide. In contrast, these same CTL lines incubated with their cognate peptide, allowing them to present peptide to each other, adhered to the sides of the well and were readily distinguished by macroscopic visual examination of the plate after 4-5 h or overnight incubation. This CTL adherence assay (CAA) demonstrated peptide specificity and MHC restriction, and was titratable with peptide concentration. With this technique, a minimal-sized Plasmodium falciparum CTL epitope was correctly identified from a panel of overlapping nonamers, although the adherence pattern of 2 mono-substituted variant peptides was less predictive of lytic activity. Substitutions in an HIV-1 envelope CTL epitope that reduced lytic activity were correctly predicted. On preincubation, inhibitors of RNA and protein synthesis abrogated the adherence, indicating a need for live cells. Wortmannin, a PI-3 kinase inhibitor, inhibited the peptide specific adherence, consistent with a role for TCR or integrin signal transduction in CAA. Other cytoskeletal and metabolic inhibitors had no effect. Adherence of the T cells appeared to involve low affinity nonspecific interactions. CAA may represent a rapid simple method for screening large numbers of peptides to find cytolytic epitopes for a given CTL line and may identify additional epitopes causing T cell activation and adherence, but not cytolytic activity. KW - assays KW - cell lines KW - cytoadherence KW - epitopes KW - immune response KW - in vitro KW - inhibitors KW - laboratory animals KW - major histocompatibility complex KW - methodology KW - parasites KW - peptides KW - T lymphocytes KW - techniques KW - mice KW - Plasmodium falciparum KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - antigenic determinants KW - cell adhesion KW - histocompatibility complex KW - immunity reactions KW - immunological reactions KW - methods KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970802387&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs. AU - Kashanchi, F. AU - Sadaie, M. R. AU - Brady, J. N. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 227 IS - 2 SP - 431 EP - 438 SN - 0042-6822 AD - Kashanchi, F.: Virus Tumor Biology Section, Laboratory of Molecular Virology, National Cancer Institute, NIH Bethesda, MD 20892, USA. N1 - Accession Number: 19972002468. Publication Type: Journal Article. Language: English. Number of References: 26 ref. N2 - This is an interesting initial study which demonstrates that peptide analogues of Tat can directly inhibit HIV-1 induction from latently-infected cells after stimulation. This may be an important new approach for anti-HIV-1 gene therapy. Further studies will be necessary in primary human cell types to determine the potency of this effect as an intracellular immunization technology. KW - analogues KW - antigens KW - genes KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - microbiology KW - peptides KW - promoters KW - regulatory genes KW - replication KW - tat gene KW - transactivation KW - transcription KW - viral replication KW - Deltaretrovirus KW - Human immunodeficiency virus 1 KW - human T-cell lymphotropic virus type I KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - analogs KW - antigenicity KW - DNA transcription KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunogens KW - promoter region KW - promoter sequences KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002468&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Posttranscriptional regulation by Rev protein of human immunodeficiency virus type 1 results in nonrandom nuclear localization of gag mRNA. AU - Romanov, V. I. AU - Zolotukhin, A. S. AU - Aleksandroff, N. N. AU - Silva, P. P. da AU - Felber, B. K. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 228 IS - 2 SP - 360 EP - 370 SN - 0042-6822 AD - Romanov, V. I.: Human Retrovirus Pathogenesis Group, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972003121. Publication Type: Journal Article. Language: English. N2 - The expression of HIV-1 mRNAs containing the Rev-responsive element is regulated at the posttranscriptional level by the viral Rev protein. Rev increases the nucleocytoplasmic export of these mRNAs, leading to high expression. Using in situ hybridization and electron microscopy, the authors investigated the localization of a subgenomic gag mRNA in the absence and presence of Rev. In addition to the previously shown cytoplasmic accumulation of the Rev-dependent RNA, it was observed that in the presence of Rev the nuclear gag mRNA accumulates non randomly and forms specific localization patterns at the nuclear membrane and in the nucleoplasm. Cellular mRNAs for β-actin and glyceraldehyde-3-phosphate dehydrogenase were not found to form such patterns. These data suggest that Rev leads the gag mRNA to specific subnuclear locations, which further supports the transport function of Rev. KW - cells KW - Gag protein KW - HIV-1 infections KW - human diseases KW - localization KW - messenger rna KW - microbiology KW - regulatory genes KW - rev gene KW - Rev protein KW - transcription KW - transport KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - DNA transcription KW - human immunodeficiency virus type 1 KW - mRNA KW - transportation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003121&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations. AU - Bess, J. W., Jr. AU - Gorelick, R. J. AU - Bosche, W. J. AU - Henderson, L. E. AU - Arthur, L. O. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 230 IS - 1 SP - 134 EP - 144 SN - 0042-6822 AD - Bess, J. W., Jr.: AIDS Vaccine Program, SAIC, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972004712. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 63231-63-0, 57-50-1. N2 - Microvesicles band in sucrose gradients in a range of densities that includes the same density as retroviruses. To characterize these microvesicles, HIV-1 infected and uninfected human T-cell lines were propagated and viruses and microvesicles were purified from clarified cell culture supernatants by sucrose density gradient centrifugation or centrifugation through 20% sucrose pads. Microvesicles were found to contain various proteins, including HLA DR and β2-microglobulin (β2-M), and a substantial amount of RNA and DNA. The concentrations of HIV-1 p24CA, HLA DR and β2-M were determined by radioimmunoassay. The ratios of HIV-1 p24CA to HLA DR and β2-M varied with respect to the HIV-1 isolate, host cell, and other factors. Electron microscopic analysis of microvesicles revealed that they consisted of particles of various sizes and morphologies. Although HIV-1 particles are known to contain some cellular proteins, microvesicles from HIV-1 infected H9 cells appeared to contain little or no HIV-1 gp120SU. KW - cell lines KW - concentration KW - contamination KW - hiv infections KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - laboratory methods KW - methodology KW - proteins KW - RNA KW - sucrose KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - laboratory techniques KW - methods KW - other methods KW - ribonucleic acid KW - saccharose KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004712&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses. AU - Giri, A. AU - Slattery, J. P. AU - Heneine, W. AU - Gessain, A. AU - Rivadeneira, E. AU - Desrosiers, R. C. AU - Rosen, L. AU - Anthony, R. AU - Pamungkas, J. AU - Iskandriati, D. AU - Richards, A. L. AU - Herve, V. AU - McClure, H. AU - O'Brien, S. J. AU - Franchini, G. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 231 IS - 1 SP - 96 EP - 104 SN - 0042-6822 AD - Giri, A.: Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19972005260. Publication Type: Journal Article. Language: English. Number of References: 58 ref. N2 - A genetically diverse, monophyletic lineage consisting of 8 new viral strains from several species of Asian macaques was identified. The second lineage consisted of a monophyletic assemblage of HTLV-II/STLV-II strains from Africa and the New World, including an isolate from a pygmy chimp (Pan paniscus) as an early divergence within the lineage. High levels of genetic variation among strains from Asian STLV-I macaque suggest the virus arose in Asia. Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin. KW - diversity KW - genetic variation KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - microbiology KW - populations KW - strains KW - T lymphocytes KW - Africa KW - Asia KW - Deltaretrovirus KW - human T-cell lymphotropic virus type II KW - Macaca KW - monkeys KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - genetic variability KW - genotypic variability KW - genotypic variation KW - HTLV-BLV group KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - other Retroviridae KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005260&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. AU - Derse, D. AU - Mikovits, J. AU - Ruscetti, F. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 237 IS - 1 SP - 123 EP - 128 SN - 0042-6822 AD - Derse, D.: Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute, Frederick MD 21702-1201, USA. N1 - Accession Number: 19972010690. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - To identify possible functions for ORFs X-1 and X-II, an infectious molecular clone of HTLV-I and a mutant provirus lacking these ORFs were compared with respect to virus replication, gene expression, and ability to immortalize primary T cells. When transiently transfected into 293 cells, both intact and deleted proviruses directed the synthesis of virus mRNAs and proteins that were quantitatively and qualitatively identical. These viruses were also indistinguishable in their abilities to infect and replicate in DBS-FRhL cells, which are permissive for HTLV-I propagation. Immortalized T-cell lines were established after cell-free or coculture methods for infection of activated, human peripheral blood or cord blood lymphocytes with each of the cloned viruses. The growth kinetics, cytokine dependence, and cell surface markers of the infected T-cell cultures were similar for each provirus clone. Thus, ORFs X-1 and X-II are not essential for virus infectivity, replication, gene expression, or T-cell immortalization in vitro. KW - cell lines KW - clones KW - culture media KW - culture techniques KW - cytokines KW - HTLV-I infections KW - human diseases KW - infection KW - lymphocytes KW - open reading frames KW - proteins KW - proviruses KW - replication KW - surface proteins KW - synthesis KW - T lymphocytes KW - viral replication KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - HTLV-BLV group KW - membrane proteins KW - ORFs KW - T cells KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010690&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family. AU - Ohno, H. AU - Aguilar, R. C. AU - Fournier, M. C. AU - Hennecke, S. AU - Cosson, P. AU - Bonifacino, J. S. JO - Virology (New York) JF - Virology (New York) Y1 - 1997/// VL - 238 IS - 2 SP - 305 EP - 315 SN - 0042-6822 AD - Ohno, H.: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982000298. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 11096-37-0. N2 - The resemblance of the Env endocytic signals to other signals found in host cell proteins suggests that they may share the same endocytic machinery. This study demonstrates that this is indeed the case. Over-expression of proteins having the tyrosine-based signals of the Env complex saturates the intracellular sorting machinery and, as a consequence, increases the surface expression of the transferrin receptor (TfR), a protein that is normally internalized by virtue of a tyrosine-based signal. Furthermore, it is demonstrated that the tyrosine-based signals of the HIV-1 Env complex bind to the µ2 chain of clathrin-associated adaptor complex AP-2, a protein that was previously implicated in the endocytosis of other cellular proteins. Finally, it is shown that the same signals interact with two other members of the adaptor medium chain family, µ1 and µ3A, albeit with lower avidity. KW - cells KW - envelope glycoproteins KW - glycoproteins KW - HIV-1 infections KW - hosts KW - human diseases KW - pathogenesis KW - plasma membranes KW - proteins KW - receptors KW - transferrin KW - uptake KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cell membrane KW - human immunodeficiency virus type 1 KW - internalization KW - plasmalemma KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000298&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regulation and trafficking of three distinct 18 S ribosomal RNAs during development of the malaria parasite. AU - Li Jun AU - Gutell, R. R. AU - Damberger, S. H. AU - Wirtz, R. A. AU - Kissinger, J. C. AU - Rogers, M. J. AU - Sattabongkot, J. AU - McCutchan, T. F. JO - Journal of Molecular Biology JF - Journal of Molecular Biology Y1 - 1997/// VL - 269 IS - 2 SP - 203 EP - 213 SN - 0022-2836 AD - Li Jun: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000804060. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology N2 - Developmental progression in Plasmodium vivax is correlated with changes in regions of ribosomal RNA sequence. The A-type ribosome is predominantly found in infected erythrocytes and in the vector blood meal; transcripts from the A gene are replaced by transcripts from the O gene shortly after fertilization and increase in number as the parasite develops in the vector midgut; transcripts from the S gene begin as the parasite oocyst matures and are included in sporozoites that migrate to the salivary gland. KW - biological development KW - blood-meals KW - development KW - developmental stages KW - disease vectors KW - erythrocytes KW - gene expression KW - genes KW - life cycle KW - malaria KW - midgut KW - molecular genetics KW - nucleotide sequences KW - oocysts KW - parasites KW - ribosomal RNA KW - ribosomes KW - salivary glands KW - sporozoites KW - transcription KW - Plasmodium vivax KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - blood red cells KW - DNA sequences KW - DNA transcription KW - growth phase KW - red blood cells KW - rRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804060&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Plasmodium falciparum protein synthesis: targeting the plastid-like organelle with thiostrepton. AU - McConkey, G. A. AU - Rogers, M. J. AU - McCutchan, T. F. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 4 SP - 2046 EP - 2049 SN - 0021-9258 AD - McConkey, G. A.: Growth and Development Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19970801942. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9007-49-2, 13292-46-1. Subject Subsets: Protozoology N2 - Plasmodium falciparum has 2 extrachromosomal DNAs associated with organelles whose function is unclear. Both genomes encode ribosomal RNAs (rRNAs) that are distinct from the nuclear-encoded rRNAs. Secondary structure analysis of all the P. falciparum rRNAs indicated that only the large subunit (LSU) rRNA encoded by the plastid-like genome is the target for thiostrepton (a thiazole-containing peptide antibiotic). Thiostrepton inhibited growth of the parasite in the micromolar range, which is 10-fold lower than concentrations with observable effects on total protein synthesis. The selective effects of thiostrepton on the plastid function were further examined by comparing differential effects of the drug on cytoplasmic and organellar encoded transcripts. Treatment with either thiostrepton or rifampin [rifampicin] (an inhibitor of organellar and eubacterial RNA polymerase) showed disappearance of organellar-encoded RNA transcripts within 6 h of treatment while transcripts of a nuclear-encoded mRNA remained constant for at least 8 h. The results demonstrate a selective effect on organelle function that is suggestive of interference in the protein synthesis apparatus of the plastid. The sensitivity of P. falciparum to thiostrepton confirms that the plastid-like genome is essential for the erythrocytic cycle and presents a novel therapeutic site. KW - antimalarials KW - antiprotozoal agents KW - DNA KW - genomes KW - growth inhibitors KW - in vitro KW - inhibitors KW - mode of action KW - organelles KW - parasites KW - plastids KW - protein synthesis KW - ribosomal RNA KW - rifampicin KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - protein biosynthesis KW - rifampin KW - rifamycin amp KW - rRNA KW - thiostrepton KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970801942&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. AU - Kannan, S. AU - Santis, M. de AU - Lohmeyer, M. AU - Riese, D. J., II AU - Smith, G. H. AU - Hynes, N. AU - Seno, M. AU - Brandt, R. AU - Bianco, C. AU - Persico, G. AU - Kenney, N. AU - Normanno, N. AU - Martínez Lacaci, I. AU - Ciardiello, F. AU - Stern, D. F. AU - Gullick, W. J. AU - Salomon, D. S. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 6 SP - 3330 EP - 3335 SN - 0021-9258 AD - Kannan, S.: Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NIC, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19970401616. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9026-43-1, 60-18-4. Subject Subsets: Dairy Science N2 - Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family, interacted with a high-affinity, saturable binding site(s) on HC-11 mouse mammary epithelial cells and on several different human breast cancer cell lines. This receptor exhibits specificity for CR-1, since other EGF-related peptides including EGF, transforming growth factor-α, heparin-binding EGF-like growth factor, amphiregulin, epiregulin, betacellulin or heregulin-β1 that bind to either the EGF receptor or to other type 1 receptor tyrosine kinases such as erb B-3 or erb B-4 fail to compete for binding. Conversely, CR-1 did not directly bind to or activate the tyrosine kinases associated with the EGFR, erb B-2, erb B-3 or erb B-4 either alone or in various pairwise combinations which have been ectopically expressed in Ba/F3 mouse pro-B lymphocyte cells. However, exogenous CR-1 could induce an increase in the tyrosine phosphorylation of 185- and 120-kDa proteins and a rapid (within 3-5 min) increase in the tyrosine phosphorylation of the SH2-containing adaptor proteins p66, p52 and p46 Shc in mouse mammary HC-11 epithelial cells and in human MDA-MB-453 and SKBr-3 breast cancer cells. CR-1 also promoted an increase in the association of the adaptor Grb2-guanine nucleotide exchange factor-mouse son of sevenless (mSOS) signalling complex with tyrosine-phosphorylated Shc in HC-11 cells. Finally, CR-1 was able to increase p42erk-2 mitogen-activated protein kinase (MAPK) activity in HC-11 cells within 5-10 min of treatment. It is concluded that CR-1 can function through a receptor which activates intracellular components in the ras/raf/MEK/MAPK pathway. KW - cell lines KW - cells KW - epidermal growth factor KW - epithelium KW - growth factors KW - kinases KW - mammary gland neoplasms KW - mammary glands KW - neoplasms KW - nucleotides KW - peptides KW - phosphorylation KW - protein kinase KW - receptors KW - tyrosine KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - amphiregulin KW - betacellulin KW - cancers KW - epiregulin KW - heregulin KW - mammary tumour KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Human Physiology and Biochemistry (VV050) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970401616&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. AU - Hollander, M. C. AU - Zhan QiMin AU - Bae, I. AU - Fornace, A. J., Jr. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 21 SP - 13731 EP - 13737 SN - 0021-9258 AD - Hollander, M. C.: Laboratory of Molecular Pharmacology, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19970105595. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - Induction of the human DNA damage- and growth arrest-inducible gene, GADD34, by ionizing radiation was only seen in certain cell lines and correlated with apoptosis following ionizing radiation. In addition, the kinetics and dose response of GADD34 to ionizing radiation closely paralleled that of the apoptosis inhibitor, BAX. However, unlike BAX, the GADD34 response was independent of cellular p53 status. The C-terminus of GADD34 has homology with the C-termini of 2 viral proteins, one of which is known to prevent apoptosis of virus infected cells. The association of GADD34 expression with certain types of apoptosis and its homology with a known apoptosis regulator suggests that GADD34 may play a role in apoptosis as well. KW - apoptosis KW - dna repair KW - genes KW - kinetics KW - neoplasms KW - mammals KW - man KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - cancers KW - homology KW - tumour suppressors KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970105595&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. AU - Rumsey, S. C. AU - Kwon, O. AU - Xu GuoWei AU - Burant, C. f. AU - Simpson, I. AU - Levine, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 30 SP - 18982 EP - 18989 SN - 0021-9258 AD - Rumsey, S. C.: NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19981402542. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 50-81-7, 490-83-5, 50-99-7. Subject Subsets: Human Nutrition; Animal Nutrition N2 - Using the Xenopus laevis oocyte expression system, transport of dehydroascorbic acid (DHA) and ascorbic acid (AA) via glucose transporter isoforms GLUT1-5 and SGLT1 was studied. The apparent Km of DHA transport via GLUT1 and GLUT3 was 1.1±0.2 and 1.7±0.3 mM, respectively. HPLC analysis confirmed 100% reduction of DHA to AA within oocytes. GLUT4 transport of DHA was only 2- to 4-fold above control and transport kinetics could not be calculated. GLUT2, GLUT5, and SGLT1 did not transport DHA and none of the isoforms transported AA. Radiolabelled sugar transport confirmed transporter function and identity of all cDNA clones was confirmed by restriction fragment mapping. GLUT1 and GLUT3 cDNA were further verified by polymerase chain reaction. DHA transport activity in GLUT1 and GLUT3 was inhibited by 2-deoxyglucose, D-glucose, and 3-O-methylglucose among other hexoses while fructose and L-glucose showed no inhibition. Inhibition by the endofacial inhibitor, cytochalasin B, was non-competitive and inhibition by the exofacial inhibitor, 4,6-O-ethylidene-α-glucose, was competitive. Expressed mutant constructs of GLUT1 and GLUT3 did not transport DHA. DHA and 2-deoxyglucose uptake by Chinese hamster ovary cells overexpressing GLUT1 or GLUT3 was increased 2- to 8-fold over control cells. These studies suggest GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA. KW - absorption KW - ascorbic acid KW - cell culture KW - cell cultures KW - cells KW - dehydroascorbic acid KW - glucose KW - transport KW - vitamins KW - dextrose KW - transportation KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Animal Tissue and Cell Culture (LL700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402542&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions. AU - Alkhatib, G. AU - Berger, E. A. AU - Murphy, P. M. AU - Pease, J. E. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 33 SP - 20420 EP - 20426 SN - 0021-9258 AD - Alkhatib, G.: Correspondence address [Murphy, P. M.]: Laboratory of Host Defenses, National Institutes of Health, Bldg 10, 11N113, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008633. Publication Type: Journal Article. Language: English. Number of References: 53 ref. N2 - The chemokine receptors CXCR4, CCR2b, CCR3, and CCR5 are cell entry co-receptors for HIV-1. Using an HIV-l envelope (Env)-dependent cell-cell fusion model of entry, it was shown that CCR3 can interact with Envs from certain macrophage (M)-tropic strains (which also use CCR5), T cell line (TCL)-tropic laboratory-adapted strains (which also use CXCR4), and a dual-tropic primary isolate (which also uses CCR2b, CCR5, and CXCR4). Paradoxically, CCRl is the closest homologue to CCR3 (63% amino acid identity), but lacked HIV-1 co-receptor activity. These results confirm and extend previous reports. Replacing the N-terminal segment of CCR3 with that of CCRl abolished activity of the resulting chimera for M-tropic and TCL-tropic Envs, but not for the dual-tropic Env. Replacing extracellular loop 2 of CCR3 with that of CCRl abolished activity for TCL-tropic Envs, but not for M- and dual-tropic Envs. A chimera containing all four extracellular regions of CCR3 on a backbone of CCR1 lacked any activity. Env-CCR3 interactions were strongly inhibited by the major CCR3 ligand eotaxin, but weakly or not at all by other CCR3 ligands. With primary macrophages, eotaxin induced transient calcium flux and partially inhibited fusion with cells expressing M-tropic Envs. It is concluded that specificity determinants for different Envs are located in shared and distinct extracellular regions of CCR3, the transmembrane/cytoplasmic domains make major contributions to co-receptor function, and CCR3 may be used by certain HIV-1 strains as a cell fusion factor on macrophages. KW - cell invasion KW - cell lines KW - chemokines KW - chimaeras KW - immunology KW - macrophages KW - receptors KW - strains KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - ccr2b KW - ccr3 KW - ccr5 KW - chemokine receptors KW - chimeras KW - coreceptors KW - cxcr4 KW - human immunodeficiency virus type 1 KW - specificity KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008633&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The isolated RNase H domain of murine leukemia virus reverse transcriptase. Retention of activity with concomitant loss of specificity. AU - Zhan XinYi AU - Crouch, R. J. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 35 SP - 22023 EP - 22029 SN - 0021-9258 AD - Zhan XinYi: Correspondence address [Crouch, R. J.]: Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008631. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9068-38-6. N2 - Retroviral RNases H are similar in sequence and structure to Escherichia coli RNase HI and yet have differences in substrate specificities, metal ion requirements, and specific activities. Separation of reverse transcriptase (RT) into polymerase and RNase H domains yields an active RNase H from murine leukaemia virus (MuLV) but an inactive HIV RNase H. The "handle region" present in E.coli RNase HI but absent in HIV RNase H contributes to the binding to its substrate and when inserted into HIV RNase H results in an active enzyme retaining some degree of specificity. Here, it is shown that MuLV protein containing the C-terminal 175 amino acids with its own handle region or that of E.coli RNase HI has the same specific activity as the RNase H of RT, but retains a preference for MN2+ as the cation required for activity, and has association rate (KA) 10% that of E.coli RNase HI. However, with model substrates, specificities for removal of the tRNAPro primer and polypurine tract stability are lost, indicating specificity of RNase H of MuLV requires the remainder of the RT. Differences in KA while significant, appear insufficient to account for the differences in specific activities of the bacterial and viral RNases H. KW - amino acids KW - human immunodeficiency viruses KW - leukaemia KW - microbiology KW - molecular biology KW - molecular genetics KW - reverse transcriptase KW - ribonucleases KW - structural genes KW - retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - biochemical genetics KW - blood cancer KW - human immunodeficiency virus KW - leucaemia KW - leukemia KW - other Retroviridae KW - RNASE KW - RNase H KW - specificity KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008631&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. AU - Gong DaWei AU - He YuFang AU - Karas, M. AU - Reitman, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 39 SP - 24129 EP - 24132 SN - 0021-9258 AD - Gong DaWei: Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1770, USA. N1 - Accession Number: 19981407540. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 1926-94-9, 2265-67-7, 2392-39-4, 312-93-6, 50-02-2, 55812-90-3, 7743-96-6, 16978-57-7, 1879-72-7, 169494-85-3. Subject Subsets: Human Nutrition N2 - Uncoupling protein (UCP)3 is expressed at high levels in muscle and rodent brown adipose tissue. Overexpression in yeast reduced the mitochondrial membrane potential, showing that UCP3 is a functional uncoupling protein. UCP3 RNA levels are regulated by hormonal and dietary manipulations. In contrast, levels of UCP2, a widely expressed UCP family member, showed little hormonal regulation. In particular, muscle UCP3 levels were decreased 3-fold in hypothyroid rats and increased 6-fold in hyperthyroid rats. Thus UCP3 is a strong candidate to explain the effects of thyroid hormone on thermogenesis. White adipose UCP3 levels were greatly increased by treatment with the β3-adrenergic agonist, CL214613, suggesting another pathway for increasing thermogenesis. UCP3 mRNA levels were also regulated by dexamethasone, leptin and starvation, albeit differently in muscle and brown adipose tissue. Starvation caused increased muscle and decreased BAT UCP3, suggesting that muscle assumes a larger role in thermoregulation during starvation. The UCP3 gene is located close to that encoding UCP2, in a chromosomal region implicated in previous linkage studies as contributing to obesity. KW - adipose tissue KW - brown fat KW - dexamethasone KW - gene expression KW - heat production KW - leptin KW - obesity KW - regulation KW - skeletal muscle KW - starvation KW - thyroid gland KW - thyroid hormones KW - tissues KW - mice KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorigenesis KW - fatness KW - thermogenesis KW - thyroid KW - uncoupling protein KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407540&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro. AU - Davis, D. A. AU - Newcomb, F. M. AU - Starke, D. W. AU - Ott, D. E. AU - Mieyal, J. J. AU - Yarchoan, R. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1997/// VL - 272 IS - 41 SP - 25935 EP - 25940 SN - 0021-9258 AD - Davis, D. A.: HIV and AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010649. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 70-18-8. N2 - Previous studies have suggested that the two conserved cysteines of the HIV-1 protease may be involved in regulating protease activity. This study examined diglutathionylated wild type protease (Cys-67-SSG, Cys-95-SSG) and the monoglutathionylated protease mutants (C67A, Cys-95-SSG and C95A, Cys-67-SSG) as potential substrates for thioltransferase (glutaredoxin). Glutathione alone was not a effective reductant, whereas thioltransferase displayed differential catalysis toward the Cys-95-SSG and Cys-67-SSG sites. At low thioltransferase concentrations (5nM), deglutathionylation occurred almost exclusively at Cys-95-SSG. With substantially more thioltransferase (100 nM) Cys-67-SSG was partially deglutationylated but only at 20% of the rate of Cys-95-SSG reduction. Treatment of the diglutathionylated protease with thioltransferase not only restored protease activity but generated an enzyme preparation that had a 3- to 5-fold greater specific activity relative to the fully reduced form. Immunoblot analysis of HIV-1MN virus with an antibody to thioltransferase detected a band co-migrating with recombinant thioltransferase that persisted following subtilisin treatment, indicating the presence of thioltransferase within HIV-1. These results implicate thioltransferase in the regulation and/or maintenance of protease activity in HIV-1 infected cells. KW - analysis KW - antibodies KW - biochemistry KW - catalytic activity KW - concentration KW - glutathione KW - HIV-1 infections KW - human diseases KW - immunoblotting KW - mutants KW - proteinases KW - regulation KW - substrates KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - proteases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010649&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma leptin responses to fasting in Pima Indians. AU - Pratley, R. E. AU - Nicolson, M. AU - Bogardus, C. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1997/// VL - 273 IS - 3, 1 SP - E644 EP - E649 SN - 0002-9513 AD - Pratley, R. E.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19971411875. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9004-10-8, 169494-85-3. Subject Subsets: Human Nutrition N2 - This study examined the plasma leptin responses to a standard test meal and a subsequent 24-h fast in 231 healthy Pima Indians (35±2 years old), recruited from the Gila River Indian Community, USA, and then related these responses to changes in plasma insulin, selected metabolites and energy expenditure. Plasma leptin concentrations decreased by 8% (P<0.05) 2-4 h after the test meal. They returned to baseline 6-12 h after the subjects ate, then subsequently decreased and, by the end of the fast, were an average of 37% below baseline (P<0.0001). Changes in plasma leptin concentrations did not correlate with changes in plasma glucose, insulin, triglyceride or nonesterified fatty acid concentrations or with changes in metabolic rate. It was concluded that plasma leptin concentrations decrease in response to short-term energy restriction alone. It was suggested that the decrease in plasma leptin concentrations with fasting may be an important homeostatic response to an energy deficit, stimulating food intake and thus restoring energy balance. KW - blood KW - blood sugar KW - energy balance KW - ethnic groups KW - fasting KW - fatty acids KW - food intake KW - insulin KW - leptin KW - metabolism KW - obesity KW - responses KW - triacylglycerols KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood glucose KW - fatness KW - glucose in blood KW - triglycerides KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In search of AIDS-resistance genes. AU - O'Brien, S. J. AU - Dean, M. JO - Scientific American JF - Scientific American Y1 - 1997/// VL - 277 IS - 3 SP - 28 EP - 35 SN - 0036-8733 AD - O'Brien, S. J.: Laboratory of Genomic Diversity, National Cancer Institute, USA. N1 - Accession Number: 19972010160. Publication Type: Journal Article. Language: English. Number of References: 4 ref. N2 - This review examines the genetic factors that confer resistance against HIV-1. In particular, it focuses on the gene for the CCR5 receptor and the protective effect associated with homozygosity for the deletion mutant. Implications for treatment are discussed. KW - acquired immune deficiency syndrome KW - alleles KW - chemokines KW - cytokines KW - genes KW - HIV-1 infections KW - homozygosity KW - human diseases KW - immunology KW - pathogenesis KW - receptors KW - resistance KW - reviews KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - genetic susceptibility KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010160&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Therapeutic effect of combination antiretroviral therapy on cytomegalovirus retinitis. AU - Whitcup, S. M. AU - Fortin, E. AU - Nussenblatt, R. B. AU - Polis, M. A. AU - Muccioli, C. AU - Belfort, R., Jr. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1997/// VL - 277 IS - 19 SP - 1519 EP - 1520 SN - 0098-7484 AD - Whitcup, S. M.: National Eye Institute, Bethesda, MD, USA. N1 - Accession Number: 19972007211. Publication Type: Journal Article. Language: English. Number of References: 6 ref. KW - acquired immune deficiency syndrome KW - antiviral agents KW - case reports KW - combination therapy KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - retinitis KW - treatment KW - cytomegalovirus KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - combined modality therapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - multimodal treatment KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007211&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. AU - Smith, M. W. ( AU - et al. JO - Science (Washington) JF - Science (Washington) Y1 - 1997/// VL - 277 IS - 5328 SP - 959 EP - 965 SN - 0036-8075 AD - Smith, M. W. (: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19972008574. Publication Type: Journal Article. Language: English. Number of References: 57 ref. N2 - The critical role of chemokine receptors (CCR5 and CXCR4) in HIV-1 infection and pathogenesis prompted a search for polymorphisms in other chemokine receptor genes that mediate HIV-1 disease progression. A mutation (CCR2-641) within the first transmembrane of the CCR2 chemokine and HIV-1 receptor gene is described that occurred at an allele frequency of 10 to 15% among Caucasians and African Americans. Genetic association analysis of 5 AIDS cohorts (3003 patients) revealed that although CCR2-641 exerts no influence on the incidence of HIV-1 infection, HIV-1-infected individuals carrying the CCR2-641 allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele. Because CCR2-641 occurs invariably on a CCR5+-bearing chromosomal haplotype, the independent effects of CCR5-Δ32 (which also delays AIDS onset) and CCR2-641 were determined. An estimated 38 to 45% of AIDS patients whose disease progresses rapidly (less than 3 years until onset of AIDS symptoms after HIV-1 exposure) can be attributed to their CCR2-+/+ or CCR5-+/+ genotype, whereas the survival of 28 to 29% of long-term survivors, who avoid AIDS for 16 years or more, can be explained by a mutant genotype for CCR2 or CCR5. Editorial comment:This extremely interesting molecular epidemiological study now demonstrates that an additional variant of a chemokine receptor seems to be associated with slow progression to HIV-1-immune suppression. It has been previously shown by this and other groups that the CCR5 receptor heterologous and homozygous variant affected HIV-1 infection and in vivo replication. This new study demonstrates that the CCR2 gene may contain a mutation which favourably alters the clinical progression of HIV-1 infection in these individuals. As such, further studies will be necessary to correlate the growing number of chemokine receptors which may be associated with HIV-1 infection and transmission in vivo plus progression of disease. KW - acquired immune deficiency syndrome KW - chemokines KW - clinical aspects KW - genes KW - genotypes KW - immunology KW - receptors KW - transmembrane proteins KW - transmission KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - ccr2 KW - ccr5 KW - chemokine receptors KW - clinical picture KW - human immunodeficiency virus type 1 KW - long term KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008574&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epstein-Barr virus and the immune system. Hide and seek. AU - Cohen, J. I. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1997/// VL - 278 IS - 6 SP - 510 EP - 513 SN - 0098-7484 AD - Cohen, J. I.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972008776. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health N2 - A case is presented of Epstein-Barr virus-associated Burkitt's lymphoma in a 35-year-old man from Maryland, USA. The pathogenesis of Epstein-Barr infection is discussed. KW - Burkitt's lymphoma KW - case reports KW - human diseases KW - immune system KW - infections KW - lymphoma KW - neoplasms KW - pathogenesis KW - viral diseases KW - Maryland KW - North America KW - USA KW - Human herpesvirus 4 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - epstein-barr virus KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008776&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The risk of bovine spongiform encephalopathy ('mad cow disease') to human health. AU - Brown, P. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1997/// VL - 278 IS - 12 SP - 1008 EP - 1011 SN - 0098-7484 AD - Brown, P.: Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. N1 - Accession Number: 19982208474. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science; Animal Nutrition N2 - The link between human cases of new variant Creutzfeldt-Jakob disease in Britain and eating beef infected with the agent of bovine spongiform encephalopathy (BSE) is discussed, and reasons for and against the presumption are explained. The risk of a similar situation occurring in countries other than Britain, in particular the USA, is assessed in terms of the existence of scrapie (in sheep) or unrecognized BSE (in cattle), the practice of recycling non-edible sheep and cattle tissue as animal feed and precautionary measures already taken or under consideration by government agencies. KW - bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - disease transmission KW - feeds KW - health KW - human diseases KW - prion diseases KW - public health KW - risk factors KW - scrapie KW - UK KW - USA KW - cattle KW - sheep KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Ovis KW - British Isles KW - Western Europe KW - Europe KW - Commonwealth of Nations KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - APEC countries KW - North America KW - America KW - bovine encephalopathy KW - Britain KW - BSE KW - feeding stuffs KW - mad cow disease KW - United Kingdom KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982208474&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer incidence after retinoblastoma: radiation dose and sarcoma risk. AU - Wong, F. L. AU - Boice, J. D., Jr. AU - Abramson, D. H. AU - Tarone, R. E. AU - Kleinerman, R. A. AU - Stovall, M. AU - Goldman, M. B. AU - Seddon, J. M. AU - Tarbell, N. AU - Fraumeni, J. F., Jr. AU - Li, F. P. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1997/// VL - 278 IS - 15 SP - 1262 EP - 1267 SN - 0098-7484 AD - Wong, F. L.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003541. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health N2 - The objective of this study was to examine the long-term risk of new primary neoplasms in survivors of childhood retinoblastoma and quantify the role of radiotherapy in sarcoma development. A cohort of 1604 patients with retinoblastoma identified from hospital records in Massachusetts and New York, USA between 1914 and 1984, who survived for ≥one year after diagnosis and were known to be alive in 1925 or later, were followed up. Follow-up began 1 year after diagnosis of retinoblastoma and ended at date of loss to follow-up (n=112, median duration=4.2 years), the date of death (n=330) or December 1993 (n=1162). Incidence of subsequent cancers (recorded on 2 occasions, between 1987 and 1988 and in 1993, during telephone interviews) was significantly elevated only in the 961 patients with hereditary retinoblastoma, in whom 190 cancers were diagnosed vs. 6.3 expected in the general population (relative risk [RR], 30; 95% confidence interval, 26-47). Cumulative incidence (±s.e.) of a second cancer at 50 years after diagnosis was 51.0% (±6.2%) for hereditary retinoblastoma and 5.0% (±3.0%) for non-hereditary retinoblastoma. All 114 sarcomas of diverse histological types occurred in patients with hereditary retinoblastoma. For soft tissue sarcomas, the RRs showed a stepwise increase at all dose categories and were significant between 10 and 29.9 Gy and between 30 and 59.9 Gy. A radiation risk for all sarcomas combined was evident at doses >5 Gy, rising to 10.7-fold at doses of ≥60 Gy (P<0.05). It is concluded that genetic predisposition has a substantial impact on risk of subsequent cancers in retinoblastoma patients, which is further increased by radiation treatment. This is the first reported demonstration of a radiation dose-response relationship in humans for soft tissue sarcomas. It is suggested that retinoblastoma patients should be examined for new cancers and followed into later life to determine whether their extraordinary cancer risk extends to common cancers of adulthood. KW - children KW - epidemiology KW - genetic factors KW - human diseases KW - incidence KW - neoplasms KW - predisposition KW - radiation KW - risk KW - risk factors KW - sarcoma KW - Massachusetts KW - New York KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Middle Atlantic States of USA KW - cancers KW - retinoblastoma KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003541&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rab 3D in rat adipose cells and its overexpression in genetic obesity (Zucker fatty rat). AU - Guerre-Millo, M. AU - Baldini, G. AU - Lodish, H. F. AU - Lavau, M. AU - Cushman, S. W. JO - Biochemical Journal (London) JF - Biochemical Journal (London) Y1 - 1997/// VL - 321 IS - 1 SP - 89 EP - 93 SN - 0264-6021 AD - Guerre-Millo, M.: Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19971405039. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 50-99-7, 86-01-1, 9004-10-8. Subject Subsets: Human Nutrition N2 - The subcellular distribution of Rab 3D, a member of the Rab 3 subfamily of low-molecular-mass GTP-binding proteins, in Sprague-Dawley rat adipose cells was examined, given the hypothesis that this protein might be involved in insulin-stimulated GLUT4 exocytosis. Rab 3D immunoreactivity was associated predominantly with the high-density microsomal fraction, where the signal intensity was 3- and 7-fold greater than that in plasma membranes and low-density microsomes respectively. Rab 3D did not co-localize with GLUT4 on immuno-isolated intracellular vesicles and, unlike GLUT4, it is not redistributed in response to insulin. Thus, if Rab 3D plays a role in GLUT4 trafficking, it relies on mechanisms independent of relocation. Rab 3D was overexpressed in adipose cells of obese (fa/fa) Zucker rats, in a tissue- and isoform-specific manner. The pathophysiological significance of this defect remains elusive. This could form the molecular basis for altered adipose secretory function in obesity. KW - adipocytes KW - adipose tissue KW - binding proteins KW - gene expression KW - glucose KW - guanosine triphosphate KW - insulin KW - microsomes KW - obesity KW - transporters KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - dextrose KW - fat cells KW - fatness KW - implement trailers KW - implement transporters KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405039&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS. AU - Sei, Y. AU - Nishida, K. AU - Kustova, Y. AU - Markey, S. P. AU - Morse, H. C., III AU - Basile, A. S. JO - European Journal of Pharmacology JF - European Journal of Pharmacology Y1 - 1997/// VL - 325 IS - 1 SP - 81 EP - 84 SN - 0014-2999 AD - Sei, Y.: Laboratory of Neuroscience, NIDDK, Bldg 8, Rm 111, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19972006250. Publication Type: Journal Article. Language: English. Number of References: 14 ref. N2 - Tumour necrosis factor-α (TNF-α) and platelet-activating factor (PAF) have been implicated in the pathogenesis of HIV-associated encephalopathy. The effects of pentoxifylline on brain PAF levels were examined in mice infected with the LP-BM5 murine leukaemia virus (MuLV). 7 weeks after viral inoculation , significant increases in serum TNF-α and brain PAF levels were observed. One week of treatment with pentoxifylline initiated 6 weeks post-infection significantly reduced both serum TNF-α and brain PAF levels. A significant positive correlation was observed between the levels of these substances (r=0.62; P<0.01). This study demonstrated that pentoxifylline treatment was effective in decreasing the levels of TNF-α in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV. KW - acquired immune deficiency syndrome KW - brain KW - immunomodulators KW - inoculation KW - leukaemia KW - necrosis KW - platelet activating factor KW - treatment KW - mice KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - blood cancer KW - cerebrum KW - leucaemia KW - leukemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006250&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The treatment of chronic viral hepatitis. AU - Hoofnagle, J. H. AU - Bisceglie, A. M. di JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 336 IS - 5 SP - 347 EP - 356 SN - 0028-4793 AD - Hoofnagle, J. H.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010396. Publication Type: Journal Article. Language: English. Number of References: 106 ref. Registry Number: 9008-11-1. Subject Subsets: Public Health N2 - Drug therapy for chronic hepatitis B, hepatitis delta, and hepatitis C is reviewed, including clinical and serological features, therapy with interferon alpha, indications for therapy, indicators of a response to therapy, therapy of atypical forms and new approaches to therapy. KW - chronic infections KW - clinical aspects KW - drug therapy KW - hepatitis B KW - hepatitis C KW - hepatitis D KW - human diseases KW - interferon KW - reviews KW - serology KW - viral diseases KW - viral hepatitis KW - hepatitis B virus KW - hepatitis C virus KW - hepatitis delta virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Deltavirus KW - negative-sense ssRNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - clinical picture KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. AU - Alter, H. J. AU - Nakatsuji, Y. AU - Melpolder, J. AU - Wages, J. AU - Wesley, R. AU - Shih, J. W. K. AU - Kim, J. P. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 336 IS - 11 SP - 747 EP - 754 SN - 0028-4793 AD - Alter, H. J.: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972010188. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9000-86-6. Subject Subsets: Public Health N2 - Serum samples collected in the USA in 1972-95 from 357 transfusion recipients, 157 controls who did not receive transfusions, 500 randomly selected blood donors, and 230 donors of blood received by hepatitis G virus (HGV)-infected patients were tested for HGV RNA by qualitative and quantitative polymerase-chain-reaction assays. Samples obtained before transfusion and serially after transfusion from 79 of 81 transfusion recipients who had transfusion-associated non-A, non-B hepatitis were also tested. Of the 79 patients with transfusion-associated hepatitis, 63 (80%) had infections related to the hepatitis C virus (HCV) and 3 had preexisting HCV and the cause of their acute hepatitis could not be determined; of the remaining 13 patients, 3 had acute HGV infection, and 10 were infected with unidentified agents. Six of the 63 patients with HCV infection who were tested (10%) were also infected with HGV. The 3 patients infected only with HGV had mild hepatitis (mean peak alanine aminotransferase concentration 198 U per litre; none had jaundice); the concentrations of alanine aminotransferase and HGV RNA were not well correlated. The combined HCV and HGV infections were no more severe than HCV infections alone; the alanine aminotransferase values paralleled the concentrations of HCV RNA, but not those of HGV RNA. There were 35 HGV infections among the 357 transfusion recipients; only 3 had hepatitis with HGV as the sole viral marker. One of the 157 controls and 7 of the 500 randomly selected blood donors (1.4%) had detectable HGV RNA. In all 8 instances in which a transfusion recipient had acute HGV infection after transfusion and samples from all donors could be tested, at least one HGV-positive donor was identified. It was concluded that HGV was common in a group of blood donors, and it can be transmitted by transfusion. Most HGV infections were not associated with hepatitis. HGV did not worsen the course of concurrent HCV infection. No causal relation between HGV and hepatitis has been established. KW - alanine aminotransferase KW - blood donors KW - blood transfusion KW - disease transmission KW - epidemiology KW - hepatitis KW - hepatitis C KW - human diseases KW - incidence KW - liver KW - liver diseases KW - pathogenesis KW - viral hepatitis KW - USA KW - hepatitis C virus KW - hepatitis G virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - gb virus KW - glutamate pyruvate transaminase KW - glutamic pyruvic transaminase KW - GPT KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Monoclonal origin of multicentric Kaposi's sarcoma lesions. AU - Rabkin, C. S. AU - Janz, S. AU - Lash, A. AU - Coleman, A. E. AU - Musaba, E. AU - Liotta, L. AU - Biggar, R. J. AU - Zhuang ZhengPing JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 336 IS - 14 SP - 988 EP - 993 SN - 0028-4793 AD - Rabkin, C. S.: Viral Epidemiology Branch, National Cancer Institute, EPN/434, Bethesda, MD 20892, USA. N1 - Accession Number: 19972004504. Publication Type: Journal Article. Language: English. Number of References: 23 ref. N2 - These data indicate that Kaposi's sarcoma is a disseminated monoclonal cancer and that the changes that permit the clonal outgrowth of spindle cells occur before the disease spreads.Editorial Comment:This interesting study adds to our understanding of the pathogenesis of KS. Presumably KSHV (HHV-8) somehow induces a clonal transformation of spindle cells which proliferate into a tumour. The key question is how to prevent acquisition of this viral infection and to treat it before KS develops. KW - aetiology KW - clinical aspects KW - clones KW - disseminated infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - infections KW - Kaposi's sarcoma KW - monoclonal antibodies KW - neoplasms KW - pathogenesis KW - sarcoma KW - viral diseases KW - Herpesviridae KW - human herpesvirus 8 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - dsDNA viruses KW - DNA viruses KW - Herpesviridae KW - Rhadinovirus KW - Gammaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - causal agents KW - clinical picture KW - etiology KW - human immunodeficiency virus KW - spindle cells KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004504&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. AU - Struewing, J. P. AU - Hartge, P. AU - Wacholder, S. AU - Baker, S. M. AU - Berlin, M. AU - McAdams, M. AU - Timmerman, M. M. AU - Brody, L. C. AU - Tucker, M. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 336 IS - 20 SP - 1401 EP - 1408 SN - 0028-4793 AD - Struewing, J. P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19972010064. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health N2 - Blood samples were collected from 5318 Jewish men and women from Washington DC, USA, who had filled out epidemiological questionnaires [date not given]. Carriers of the 185delAG and 5382insC mutations in BRCA1 and the 6174delT mutation in BRCA2 were identified with assays based on the polymerase chain reaction. The risks of breast and other cancers were estimated by comparing the cancer histories of relatives of carriers of the mutations and noncarriers. 120 carriers of a BRCA1 or BRCA2 mutation were identified. By the age of 70, among carriers, the estimated risk of breast cancer was 56% (95% confidence interval, 40-73%), the estimated risk of ovarian cancer was 16% (95% confidence interval, 6-28%) and the estimated risk of prostate cancer, 16% (95% confidence interval, 4-30%). There were no significant differences in the risk of breast cancer between carriers of BRCA1 mutations and carriers of BRCA2 mutations and the incidence of colon cancer among the relatives of carriers was not elevated. It is concluded that >2% of Ashkenazi Jews carry mutations in BRCA1 or BRCA2 that confer increased risks of breast, ovarian and prostate cancer. The risks of breast cancer may be overestimated, but they fall well below previous estimates based on subjects from high-risk families. KW - breast cancer KW - carriers KW - epidemiology KW - ethnic groups KW - genetic factors KW - genotypes KW - human diseases KW - mutations KW - neoplasms KW - ovaries KW - prostate KW - risk KW - risk factors KW - District of Columbia KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010064&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. AU - Blauvelt, A.\Herndier, B. G.\Orenstein, J. M.\Friborg, J., Jr.\Nabel, G. J.\Nickoloff, B. J. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 336 IS - 25 SP - 1837 EP - 1839 SN - 0028-4793 AD - National Cancer Institute, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19972006228. Publication Type: Correspondence. Language: English. Number of References: 5 ref. KW - acquired immune deficiency syndrome KW - epidemiology KW - human diseases KW - human immunodeficiency viruses KW - kaposi's sarcoma KW - Herpesviridae KW - human herpesvirus 8 KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - dsDNA viruses KW - DNA viruses KW - Herpesviridae KW - Rhadinovirus KW - Gammaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006228&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. AU - Linet, M. S. AU - Hatch, E. E. AU - Kleinerman, R. A. AU - Robison, L. L. AU - Kaune, W. T. AU - Friedman, D. R. AU - Severson, R. K. AU - Haines, C. M. AU - Hartsock, C. T. AU - Niwa, S. AU - Wacholder, S. AU - Tarone, R. E. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 1 SP - 1 EP - 7 SN - 0028-4793 AD - Linet, M. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Suite 408, Bethesda, MD 20892-7362, USA. N1 - Accession Number: 19972008101. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health N2 - Previous studies found associations between childhood leukaemia and surrogate indicators of exposure to magnetic fields (the power-line classification scheme known as "wire coding"), but not between childhood leukaemia and measurements of 60-Hz residential magnetic fields. 638 children with acute lymphoblastic leukaemia (ALL) who were under 15 years of age and were registered with the Children's Cancer Group and 620 controls were enrolled in a study in the USA of residential exposure to magnetic fields generated by nearby power lines. In the subjects' current and former homes, data collectors blinded to the subjects' health status measured magnetic fields for 24 hours in each child's bedroom and for 30 seconds in three or four other rooms and outside the front door. A computer algorithm assigned wire-code categories, based on the distance and configuration of nearby power lines, to the subjects' main residences (for 416 case patients and 416 controls) and to those where the family had lived during the mother's pregnancy with the subject (for 230 case patients and 230 controls). The risk of childhood ALL was not linked to summary time-weighted average residential magnetic-field levels, categorized according to a priori criteria. The odds ratio for ALL was 1.24 (95% confidence interval, 0.86 to 1.79) at exposures of 0.200 µT or greater as compared with less than 0.065 µT. The risk of ALL was not increased among children whose main residences were in the highest wire-code category (odds ratio as compared with the lowest category, 0.88; 95% confidence interval, 0.48 to 1.63). Furthermore, the risk was not significantly associated with either residential magnetic-field levels or the wire codes of the homes mothers resided in when pregnant with the subjects. These results provide little evidence that living in homes characterized by high measured time-weighted average magnetic-field levels or by the highest wire-code category increases the risk of ALL in children. KW - algorithms KW - children KW - classification KW - dwellings KW - exposure KW - human diseases KW - indicators KW - leukaemia KW - magnetic field KW - neoplasms KW - radiation KW - risk factors KW - North America KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - acute lymphoblastic leukaemia KW - blood cancer KW - cancers KW - human health KW - leucaemia KW - leukemia KW - United States of America KW - Human Reproduction and Development (VV060) KW - Human Health and the Environment (VV500) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008101&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trial of calcium to prevent preeclampsia. AU - Levine, R. J. AU - Hauth, J. C. AU - Curet, L. B. AU - Sibai, B. M. AU - Catalano, P. M. AU - Morris, C. D. AU - Simonian, R. der AU - Esterlitz, J. R. AU - Raymond, E. G. AU - Bild, D. E. AU - Clemens, J. D. AU - Cutler, J. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 2 SP - 69 EP - 76 SN - 0028-4793 AD - Levine, R. J.: Division of Epidemiology, Statistics and Prevention Research, National Institutes of Health, Bldg. 6100, Rm. 7B03, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19971410969. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition N2 - 4589 healthy nulliparous women who were 13-21 weeks pregnant were randomly assigned to receive elemental Ca 2 g/day or placebo for the remainder of their pregnancies. Surveillance for preeclampsia was conducted by personnel unaware of treatment-group assignments, using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits, protocols for monitoring these measurements during the hospitalization for delivery and reviews of medical records of unscheduled outpatient visits and all hospitalizations. Ca supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. Preeclampsia occurred in 158 of the 2295 women in the Ca group (6.9%) and 168 of the 2294 women in the placebo group (7.3%) (relative risk, 0.94; 95% confidence interval, 0.76-1.16). There were no significant differences between the 2 groups in the prevalence of pregnancy-associated hypertension without preeclampsia (15.3% vs. 17.3%) or of all hypertensive disorders (22.2% vs. 24.6%). The mean systolic and diastolic blood pressures during pregnancy were similar in both groups. Ca did not reduce the numbers of preterm deliveries, small-for-gestational-age births, or fetal and neonatal deaths; nor did it increase urolithiasis during pregnancy. KW - blood pressure KW - calcium KW - fetal death KW - hypertension KW - infants KW - minerals KW - neonatal mortality KW - preeclampsia KW - pregnancy KW - premature infants KW - supplements KW - urolithiasis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calcium supplements KW - foetal death KW - gestation KW - high blood pressure KW - Physiology of Human Nutrition (VV120) KW - Human Reproduction and Development (VV060) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410969&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis. AU - Wilson, P. W. F. AU - Hoeg, J. M. AU - D'Agostino, R. B. AU - Silbershatz, H. AU - Belanger, A. M. AU - Poehlmann, H. AU - O'Leary, D. AU - Wolf, P. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 8 SP - 516 EP - 522 SN - 0028-4793 AD - Wilson, P. W. F.: Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA. N1 - Accession Number: 19981401923. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - Cross-sectional and longitudinal information from 429 men and 661 women in the Framingham Heart Study in the USA was studied. These subjects underwent B-mode ultrasound measurements of the carotid artery. Their mean age was 75 years, and each had attended most of the biennial clinic examinations over the 34 years before the carotid ultrasound study. Time-integrated measurements were used to assess the associations between various cardiovascular risk factors and the degree of carotid stenosis. Moderate carotid stenosis (≥25%) was present in 189 men and 226 women. The odds ratios for this degree of stenosis was compared with minimal stenosis (<25%) according to increases in risk factors. In the men, the odds ratio for moderate carotid stenosis associated with an increase of 20 mmHg in systolic blood pressure was 2.11 (95% confidence interval, 1.51-2.97). The odds ratio for an increase of 10 mg/100 ml (0.26 mmol/litre) in the cholesterol level was 1.10 (95% confidence interval, 1.03 to 1.16), and for an increase of 5 pack-years of smoking it was 1.08 (95% confidence interval, 1.03-1.13). The results were similar in the women. Time-integrated measurements of diastolic blood pressure showed significant associations with carotid stenosis in men and insignificant associations in women. It is concluded that over the long term, high systolic blood pressure, high cholesterol levels and smoking were associated with an increased risk of carotid stenosis in this elderly population. KW - blood KW - blood pressure KW - cardiovascular diseases KW - cholesterol KW - men KW - old age KW - risk factors KW - stenosis KW - tobacco smoking KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401923&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ethical complexities of conducting research in developing countries. AU - Varmus, H. AU - Satcher, D. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 14 SP - 1003 EP - 1005 SN - 0028-4793 AD - Varmus, H.: National Institutes of Health, Bethesda, MD 20892-0148, USA. N1 - Accession Number: 19972009881. Publication Type: Journal Article. Language: English. Number of References: 6 ref. N2 - The most compelling reason to use a placebo-controlled study is that it provides definitive answers to questions about the safety and value of an intervention in the setting in which the study is performed, and these answers are the point of the research. Without clear and firm answers to whether and, if so, how well an intervention works, it is impossible for a country to make a sound judgment about the appropriateness and financial feasibility of providing the intervention. If the affordable intervention is less effective than the ACTG 076 regimen-not an unlikely outcome-this information will be of little use in a country where the more effective regimen is unavailable. Equally important, it will still be unclear whether the affordable intervention is better than nothing and worth the investment of scarce health care dollars. Such studies would fail to meet the goal of determining whether a treatment that could be implemented is worth implementing. A placebo-controlled trial is not the only way to study a new intervention, but as compared with other approaches, it offers more definitive answers and a clearer view of side effects. KW - acquired immune deficiency syndrome KW - clinical trials KW - drug therapy KW - efficacy KW - ethics KW - evaluation KW - feasibility studies KW - health care KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - information KW - intervention KW - investment KW - prevention KW - regimens KW - research KW - safety KW - sociology KW - transmission KW - treatment KW - Developing countries KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - countries KW - AIDS KW - capital outlay KW - chemotherapy KW - ethics and human rights KW - feasibility KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - social aspects KW - studies KW - Third World KW - Underdeveloped Countries KW - Health Services (UU350) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009881&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Chemotherapy for AIDS-related lymphomas. AU - Wilson, W. H. AU - Sparano, J.\Straus, D. J.\Testa, M. A.\Kaplan, L. D. T2 - New England Journal of Medicine JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 16 SP - 1172 EP - 1174 SN - 0028-4793 AD - Wilson, W. H.: National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19972009901. Publication Type: Correspondence. Language: English. Number of References: 9 ref. N2 - Both Wilson and Sparano take issue with Kaplan et al. (New England Journal of Medicine (1997) 336 1641) that low-dose chemotherapy is the preferred treatment for AIDS patients with non-Hodgkin's lymphoma. Both cite cases where more aggressive chemotherapy was effective. Kaplan et al. agree that there might be exceptions, but insist that low-dose chemotherapy is effective in many patients who cannot tolerate a more toxic dose level. KW - acquired immune deficiency syndrome KW - antineoplastic agents KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphoma KW - neoplasms KW - non-Hodgkin's lymphoma KW - patients KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cancers KW - chemotherapy KW - cytotoxic agents KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009901&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Postexposure treatment of HIV-Taking some risks for safety's sake. AU - Henderson, D. K. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1997/// VL - 337 IS - 21 SP - 1542 EP - 1543 SN - 0028-4793 AD - Henderson, D. K.: National Institutes of Health Clinical Center, Bethesda, MD 20892, USA. N1 - Accession Number: 19982000437. Publication Type: Journal Article. Language: English. Number of References: 11 ref. N2 - The consequences of administering potentially toxic antiretroviral agents as chemoprophylaxis are serious. Conversely, the consequences associated with not offering treatment, the possibility of an increased risk of occupational HIV infection, were and remain at least as serious. The data presented by Cardo, D. M. (et al.) [New England Journal of Medicine (1997) 337, 1485] provide additional evidence that chemoprophylaxis may well be worthwhile after occupational exposure and may be a reasonable option after any type of exposure to HIV. KW - antiviral agents KW - chemoprophylaxis KW - drug therapy KW - exposure KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - occupational hazards KW - prophylaxis KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000437&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA. AU - Goedert, J. J. AU - Kedes, D. H. AU - Ganem, D. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 349 IS - 9062 SP - 1368 EP - 1368 SN - 0140-6736 AD - Goedert, J. J.: Viral Epidemiology Branch, National Cancer Institute, Rockville MD 20852, USA. N1 - Accession Number: 19972005349. Publication Type: Journal Article. Language: English. Number of References: 4 ref. N2 - Of the 289 pregnant women, 12 (4.2%) were seropositive for anti-HHV8. This proportion is in good agreement with findings in high-risk non-pregnant women, in whom a prevalence of 3.4% was found. The present cohort included 91 women of Haitian origin. Based on earlier work indicating a higher prevalence of Kaposi's sarcoma in Haitian-born heterosexuals with AIDS compared with those born in the USA (6.3% vs 1.8%), the prevalence of HHV8 seropositivity was tested in this subgroup. Nine (10%) of 91 Haitian women were positive, significantly higher than the proportion (3/198, 1.5%) among other women (P=0.002, two-tailed Fisher's exact test). HHV8 seropositivity was not increased in women with HIV-1 infection, either among Haitian (1/28, 3.6%) or non-Haitian (2/118, 1.7%) women. All 189 infants were seronegative for HHV8, including 26 who were infected with HIV-1. Notably, none of the 9 children born to HHV8-seropositive mothers was HHV8-seropositive when tested at a median age of 12 months. KW - acquired immune deficiency syndrome KW - antibodies KW - children KW - epidemiology KW - heterosexuality KW - HIV-1 infections KW - human diseases KW - immune response KW - infants KW - Kaposi's sarcoma KW - mothers KW - pregnancy KW - women KW - Haiti KW - USA KW - Herpesviridae KW - Human herpesvirus 4 KW - human herpesvirus 8 KW - Human immunodeficiency virus 1 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - Rhadinovirus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - Caribbean Community KW - Hispaniola KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Least Developed Countries KW - Developing Countries KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AIDS KW - Epstein-Barr virus KW - gestation KW - heterosexuals KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) KW - Women (UU500) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005349&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hidden dangers of incompletely suppressive antiretroviral therapy. AU - Feinberg, M. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 349 IS - 9063 SP - 1408 EP - 1409 SN - 0140-6736 AD - Feinberg, M.: Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19972005990. Publication Type: Journal Article. Language: English. Number of References: 7 ref. N2 - Several important principles can be used to guide the choice of antiretroviral therapy. First, it is likely that HIV variants resistant to one or more drugs are already present in untreated patients. Second, the likelihood that drug-resistant variants are already present in an HIV-infected patient decreases as the number of non-cross-resistant antiretroviral drugs used in combination is increased. Third, in untreated patients the prevalence of HIV variants with high-level drug resistance through multiple mutations is also expected to decline as the number of mutations required for such resistance increases. (The need for multiple mutations to confer high-level resistance is seen with certain protease inhibitors such as ritonavir and indinavir.) Fourth, incomplete suppression of HIV replication will offer the opportunity for accumulation during continuing therapy of mutations that result in high-level drug resistance to even the most potent drugs available. KW - antiviral agents KW - clinical trials KW - drug resistance KW - drugs KW - human immunodeficiency viruses KW - inhibitors KW - mutations KW - proteinase inhibitors KW - proteinases KW - replication KW - resistance KW - treatment KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - medicines KW - pharmaceuticals KW - protease inhibitors KW - proteases KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005990&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. AU - Pettitt, D. J. AU - Forman, M. R. AU - Hanson, R. L. AU - Knowler, W. C. AU - Bennett, P. H. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 350 IS - 9072 SP - 166 EP - 168 SN - 0140-6736 AD - Pettitt, D. J.: Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014, USA. N1 - Accession Number: 19970404019. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Dairy Science; Human Nutrition N2 - Infant feeding data for the first 2 months of life were obtained from a questionnaire given to mothers of 720 Pima Indians, 10-39 years old. Height and weight were measured and subjects were subjected to a 75 g oral glucose tolerance test. 325 subjects who were exclusively bottle-fed had higher age- and sex-adjusted mean relative weights (146%) than 144 who were exclusively breast-fed (140%) or 251 who were partially breast fed (139%) (P=0.019). Subjects who were exclusively breast-fed had lower rates of non-insulin dependent diabetes mellitus (NIDDM) than those who were exclusively bottle-fed in all age groups (age 10-19, 0 of 56 vs. 6 of 165 (3.6%), age 20-29, 5 of 58 (8.6%) vs. 17 of 116 (14.7%), age 30-39, 6 of 30 (20.0%) vs. 13 of 44 (29.6%)). The odds ratio for NIDDM in exclusively breast-fed subjects, compared with those exclusively bottle-fed, was 0.41 (95% confidence interval 0.18-0.93) adjusted for age, sex, birth date, parental diabetes and birthweight. It is concluded that exclusive breast feeding for the first 2 months of life is associated with a reduced risk of NIDDM in Pima Indians. The increase in prevalence of NIDDM in some populations may be due to the concomitant decrease in breast feeding. KW - body weight KW - breast feeding KW - children KW - diabetes KW - diabetes mellitus KW - ethnic groups KW - glucose tolerance test KW - incidence KW - infant feeding KW - infants KW - men KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970404019&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues. AU - Rothman, N. AU - Cantor, K. P. AU - Blair, A. AU - Bush, D. AU - Brock, J. W. AU - Helzlsouer, K. AU - Zahm, S. H. AU - Needham, L. L. AU - Pearson, G. R. AU - Hoover, R. N. AU - Comstock, G. W. AU - Strickland, P. T. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 350 IS - 9073 SP - 240 EP - 244 SN - 0140-6736 AD - Rothman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19980502383. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 50-29-3. Subject Subsets: Medical & Veterinary Entomology; Public Health; Agricultural Entomology N2 - The steady worldwide increase in the incidence of non-Hodgkin lymphoma (NHL) during the past few decades remains mostly unexplained. Several studies suggest that there may be an association between the agricultural use of DDT and increased risk of NHL. The authors investigated the association between risk of NHL and body burden of selected organochlorines (OCs) in the general population in a nested case-control study. Prediagnostic serum concentrations of DDT, its metabolites and others OC, including polychlorinated biphenyls (PCBs), were measured in 74 cases of NHL and 147 matched controls identified from a prospective cohort of 25 802 adults, established in Washington County, Maryland, USA. There was a strong dose-response relation between quartiles of total lipid-corrected serum PCB concentrations and risk of NHL overall (odds ratio by quartile: 1.0; 1.3 (95% CI 0.5-3.3); 2.8 (1.1-7.6); and 4.5 (1.7-12.0); P for trend = 0.0008) and separately in men and in women. There was also evidence suggesting that seropositivity for Epstein-Barr virus early antigen potentiated the effects of serum PCBs. By contrast, total lipid-corrected serum concentrations of DDT were not associated with risk of NHL. The authors counsel caution with the interpretation of these results. KW - agricultural entomology KW - DDT KW - epidemiology KW - insecticide residues KW - lipids KW - lymphoma KW - metabolites KW - non-Hodgkin's lymphoma KW - nontarget effects KW - organochlorine compounds KW - organochlorine insecticides KW - pesticide residues KW - pesticides KW - polychlorinated biphenyls KW - residues KW - serum KW - Maryland KW - USA KW - Human herpesvirus 4 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - dicophane KW - Epstein-Barr virus KW - lipins KW - organic chlorine compounds KW - PCBs KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502383&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - CCR5-Δ32 gene deletion in HIV-1 infected patients. AU - Smith, M. W. AU - Dean, M. AU - Carrington, M. AU - Huttley, G. A. AU - O'Brien, S. J. AU - Michael, N. L.\Louie, L. G.\Sheppard, H. W.\Garred, P.\Eugen-Olsen, J.\Iversen, A. K. N.\Benfield, T. L.\Svejgaard, A.\Copenhagen AIDS Study Group\Wang, B.\Palasanthiran, P.\Zeigler, J.\Cunningham, A.\Saksena, N. K. T2 - Lancet (British edition) JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 350 IS - 9079 SP - 741 EP - 742 SN - 0140-6736 AD - Smith, M. W.: Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19972008583. Publication Type: Correspondence. Language: English. Number of References: 9 ref. N2 - P Garred (et al.) [Lancet (1997) 349, 1884] present a survival analysis of a cohort including 99 HIV-1 exposed Danish homosexuals, which suggested that individuals heterozygous for a 32 base-pair deletion of the CCR5 receptor gene (CCR5Δ32) progress to death more rapidly after AIDS diagnosis than do homozygous wild-type individuals. The authors' study included 210 CCR5Δ32/+ heterozygotes who were indistinguishable from 949 CCR5-+/+ homozygotes in progression to death once AIDS was diagnosed. The observed tendency, although not significant, was for CCR5-+/Δ32 individuals to progress more slowly to death than CCR5-+/+ patients. Their conclusion is that the CCR5-Δ32 mediated postponement of AIDS pathology has been confirmed, but that the proposed association of CCR5-+/Δ32 genotype with rapid decline to death after a diagnosis of AIDS has been made was not confirmed. KW - acquired immune deficiency syndrome KW - chemokines KW - genotypes KW - immunology KW - receptors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - ccr5 KW - chemokine KW - chemokine receptors KW - gene deletion KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008583&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - "Love's labours lost": failure to implement mass vaccination against group A meningococcal meningitis in sub-Saharan Africa. AU - Robbins, J. B. AU - Towne, D. W. AU - Gotschlich, E. C. AU - Schneerson, R. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// VL - 350 IS - 9081 SP - 880 EP - 882 SN - 0140-6736 AD - Robbins, J. B.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2720, USA. N1 - Accession Number: 19982005963. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Tropical Diseases N2 - The reasons why, despite the effectiveness, safety, stability and cheapness of the group A meningococcal capsular polysaccharide vaccine, another epidemic of group A meningococcal meningitis occurred in sub-Saharan Africa in 1996 are discussed. The immunological properties of the group A vaccine (as well as those of the group B and C vaccines) are discussed, and clinical trials (carried out in sub-Saharan Africa) which demonstrate the vaccine's efficacy are reported. The details of group A meningococcal meningitis epidemics in Nigeria (in 1979), Rwanda (1980) and Mali (1981) are given, and the failure of selective vaccination programmes to prevent such epidemics is discussed. It is suggested that group A meningococcal epidemic prevention and eradication could be achieved by mass vaccination of the entire population. The fact that clinical agencies in sub-Saharan Africa favoured selective vaccination over mass vaccination is thought to be the cause of the 1996 epidemic. KW - bacterial diseases KW - bacterial meningitis KW - children KW - disease control KW - disease prevention KW - epidemics KW - human diseases KW - immunization KW - meningitis KW - outbreaks KW - vaccination KW - Africa KW - Africa South of Sahara KW - man KW - Neisseria meningitidis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Neisseria KW - Neisseriaceae KW - Neisseriales KW - Betaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Africa KW - bacterial infections KW - bacterioses KW - bacterium KW - immune sensitization KW - Meningococcus KW - subsaharan Africa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antigenic variation in Giardia lamblia and the host's immune response. AU - Nash, T. E. A2 - F.Y. Liew A2 - K. Vickerman. JO - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences JF - Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Y1 - 1997/// VL - 352 IS - 1359 SP - 1369 EP - 1375 SN - 0962-8436 AD - Nash, T. E.: Laboratory of Parasitic Diseases, Gastrointestinal Parasites Section, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980800377. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Protozoology N2 - Antigenic variation in Giardia lamblia [G. duodenalis] is reviewed. The antigens involved belong to a family of variant-specific surface proteins (VSPs) which are unique, cysteine-rich zinc finger proteins. Changes in VSP expression occur within the population in vivo owing to selection of VSPs by both immune and non-immune mechanisms. After inoculation of a single G. lamblia clone (able to persist in the absence of immune pressure) expressing one VSP (≥90%) into mice or humans, the original VSP continues to be expressed until 2 weeks pi, when other VSPs gradually replace it. Selection by immune-mediated processes is suggested because switching occurs at the same time that humoral responses are first detected. Almost all trophozoites are eliminated at 3 weeks pi but a barely detectable infection persists over months. In neonatal mice, apparent self-cure is delayed until 6 or 7 weeks pi. Antigenic switching does not occur in adult or immunodeficient (SCID) mice but does occur in neonatal nude mice, implicating B-cell-mediated mechanisms in immune switching. Not all VSPs are expressed to the same degree in vivo. The purpose of antigenic variation may be presentation of a wide assortment of VSPs to hosts, increasing the chance of a successful initial infection or reinfection. Immune selection of variants comes into play following biological selection. KW - antigenic variation KW - antigens KW - B lymphocytes KW - immune response KW - parasites KW - proteins KW - reviews KW - selection KW - surface proteins KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - B cells KW - immunity reactions KW - immunogens KW - immunological reactions KW - membrane proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980800377&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Metabolism of food-derived heterocyclic amines in nonhuman primates. AU - Snyderwine, E. G. AU - Turesky, R. J. AU - Turteltaub, K. W. AU - Davis, C. D. AU - Sadrieh, N. AU - Schut, H. A. J. AU - Nagao, M. AU - Sugimura, T. AU - Thorgeirsson, U. P. AU - Adamson, R. H. AU - Thorgeirsson, S. S. JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis Y1 - 1997/// VL - 376 IS - 1/2 SP - 203 EP - 210 SN - 0027-5107 AD - Snyderwine, E. G.: Laboratory of Experimental Carcinogenesis, Building 37, Room 3C28, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19981406026. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition KW - amines KW - carcinogens KW - cooking KW - foods KW - heterocyclic nitrogen compounds KW - metabolism KW - mutagens KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406026&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pirated genes in Kaposi's sarcoma. AU - Murphy, P. M. JO - Nature (London) JF - Nature (London) Y1 - 1997/// VL - 385 IS - 6614 SP - 296 EP - 299 SN - 0028-0836 AD - Murphy, P. M.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N113, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972003525. Publication Type: Journal Article. Language: English. Number of References: 15 ref. KW - acquired immune deficiency syndrome KW - chemokines KW - genes KW - HIV-1 infections KW - human diseases KW - kaposi's sarcoma KW - neoplasms KW - oncogenes KW - pathogenesis KW - receptors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - cancers KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003525&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - A new SIV co-receptor, STRL33. AU - Alkhatib, G. AU - Liao Fang AU - Berger, E. A. AU - Farber, J. M. AU - Peden, K. W. C. T2 - Nature (London) JO - Nature (London) JF - Nature (London) Y1 - 1997/// VL - 388 IS - 6639 SP - 238 EP - 238 SN - 0028-0836 AD - Alkhatib, G.: Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19972006810. Publication Type: Correspondence. Language: English. Number of References: 18 ref. N2 - It is reported that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms, is a co-receptor for SIV. Together with a previous report that STRL33 functions with HIV-1 strains of diverse tropisms [Liao, F. (et al.) Journal of Experimental Medicine (1997), 185, 2015], these results with SIV demonstrate that STRL33 is active with a broader range of Envs than has been described for any of the co-receptors so far discovered. This attribute suggests that STRL33 will be of particular value in unravelling the structural determinants of interactions between Envs and co-receptors. KW - chemokines KW - hiv infections KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - receptors KW - Human immunodeficiency virus 1 KW - simian immunodeficiency virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006810&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. AU - Raymond, G. J. AU - Hope, J. AU - Kocisko, D. A. AU - Priola, S. A. AU - Raymond, L. D. AU - Bossers, A. AU - Ironside, J. AU - Will, R. G. AU - Chen, S. G. AU - Petersen, R. B. AU - Gambetti, P. AU - Rubenstein, R. AU - Smits, M. A. AU - Lansbury, P. T., Jr. AU - Caughey, B. T2 - Nature (London) JO - Nature (London) JF - Nature (London) Y1 - 1997/// VL - 388 IS - 6639 SP - 285 EP - 288 SN - 0028-0836 AD - Raymond, G. J.: Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA. N1 - Accession Number: 19982206967. Publication Type: Correspondence. Language: English. Number of References: 26 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - In bovine spongiform encephalopathy (BSE) and other transmissible spongiform encephalopathy (TSE) diseases, the conversion of the protease-sensitive host prion protein (PrP-sen) to a protease-resistant isoform (PrP-res) is an important event in pathogenesis. Biological aspects of TSE diseases are reflected in the specificities of in vitro PrP conversion reactions. This experiment showed that there is a correlation between in vitro conversion efficiencies and known transmissibilities of BSE, sheep scrapie and CJD. On this basis, an in vitro system was used to gauge the potential transmissibility of scrapie and BSE to humans. Limited conversion of human PrP-sen to Prp-res driven by PrP-res associated with both scrapie (PrPSc) and BSE (PrPBSE) was found. The efficiencies of these heterologous conversion reactions were similar but much lower than those of relevant homologous conversions. Thus the inherent ability of these infectious agents of BSE and scrapie to affect humans following equivalent exposure may be finite but similarly low. KW - assessment KW - bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - disease transmission KW - human diseases KW - prion diseases KW - scrapie KW - zoonoses KW - man KW - sheep KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Ovis KW - Bovidae KW - ruminants KW - Artiodactyla KW - bovine encephalopathy KW - BSE KW - mad cow disease KW - zoonotic infections KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982206967&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. AU - Weissman, D. AU - Rabin, R. L. AU - Arthos, J. AU - Rubbert, A. AU - Dybul, M. AU - Swofford, R. AU - Venkatesan, S. AU - Farber, J. M. AU - Fauci, A. S. JO - Nature (London) JF - Nature (London) Y1 - 1997/// VL - 389 IS - 6654 SP - 981 EP - 985 SN - 0028-0836 AD - Weissman, D.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892,USA Correspondence address[Weissman, D.]:Division of Infectious Diseases, University of Pennsylvania Medical Center, 536 Johnson Pavillion, Philadelphia, PA 19104, USA. N1 - Accession Number: 19972010816. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - This study shows that recombinant envelope proteins from macrophage-tropic HIV and SIV induce a signal through CCR5 on CD4+ T cells and that envelope-mediated signal transduction through CCR5 induces chemotaxis of T cells. This chemotactic response may contribute to the pathogenesis of HIV in vivo by chemo-attracting activated CD4+ cells to sites of viral replication. HIV-mediated signalling through CCR5 may also enhance viral replication in vivo by increasing the activation state of target cells. Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis. Editorial comment:The present study and those of Pal, et al. (Science (1997) 278 695), and Michael et al. (Nature Medicine (1997) 3 1160), are critical in dissecting the further complexity of chemokine and chemokine receptor interactions with HIV-1 infection. In the interesting study by Weissman, et al., it is shown that macrophagetropic HIV-1 and SIV envelopes can induce signaling through the CCR5 chemokine receptor. This increase in signal transduction leads to the chemo-attraction of activated CD4+ cells. As such, this may be an important mechanism by which uninfected cells are brought to virally-infected areas in vivo. The paper by Pal, et al. is interesting in that it demonstrates a new chemokine receptor from macrophages which seems to be very important in suppressing HIV-1 expression in primary T lymphocytes. Its utility in therapy will require further studies. Finally, the paper by Michael et al. seems to contradict a previous study that a mutation in the transmembrane domain of CCR5, entitled CCR2B (641), does not inhibit HIV-1 disease progression in vivo. This is contrary to the work by Smith et al. (Science (1997) 277 959). KW - CD4+ lymphocytes KW - chemokines KW - chemotaxis KW - cytokines KW - cytopathogenicity KW - disease course KW - envelope proteins KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - macrophages KW - mutations KW - pathogenesis KW - proteins KW - receptors KW - replication KW - responses KW - T lymphocytes KW - transmembrane proteins KW - tropisms KW - viral replication KW - Human immunodeficiency virus 1 KW - simian immunodeficiency virus KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - CD4+ cells KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - T4 lymphocytes KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010816&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of fat intake on energy balance. AU - Tataranni, P. A. AU - Ravussin, E. A2 - Anderson, G. H. A2 - Rolls, B. J. A2 - Steffen, D. G. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1997/// VL - 819 SP - 37 EP - 43 SN - 0077-8923 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 19971407938. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition N2 - The short-term and long-term effects of fat intake on energy balance are reviewed. The role of genetics in the variability of the metabolic response to fat intake is considered. It is concluded that a possible explanation for the epidemic of obesity in response to high-fat intake can be found in the oxidative hierarchy that regulates macronutrient balance in the human body. Fat intake does not promote fat oxidation and excess fat intake results in fat deposition and a new equilibrium is reached. KW - adipose tissue KW - body fat KW - energy balance KW - fats KW - genetics KW - intake KW - lipid metabolism KW - metabolism KW - obesity KW - reviews KW - weight gain KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fat metabolism KW - fatness KW - nutritional implications of macronutrient substitutes KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407938&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Replenishment of selenium deficient rats with selenium results in redistribution of the selenocysteine tRNA population in a tissue specific manner. AU - Chittum, H. S. AU - Hill, K. E. AU - Carlson, B. A. AU - Lee ByeongJae AU - Burk, R. F. AU - Hatfield, D. L. JO - Biochimica et Biophysica Acta, Molecular Cell Research JF - Biochimica et Biophysica Acta, Molecular Cell Research Y1 - 1997/// VL - 1359 IS - 1 SP - 25 EP - 34 SN - 0167-4889 AD - Chittum, H. S.: Section on Molecular Biology of Selenium, Laboratory of Basic Research, Division of Basic Sciences, Building 37 Room 2D09, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991411793. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 52-90-4, 7782-49-2, 9014-25-9. Subject Subsets: Human Nutrition N2 - It was previously reported that the Se status of rats influenced both the steady-state levels and distributions of 2 selenocysteine (Sec) tRNA isoacceptors and that these isoacceptors differed by a single methyl group attached to the ribosyl moiety at position 34. In this study, it is demonstrated that repletion of Se-deficient rats results in a gradual, tissue-dependent shift in the distribution of these isoacceptors. Rats fed a Se-deficient diet possess a greater abundance of the species unmethylated on the ribosyl moiety at position 34 compared to the form methylated at this position. A redistribution of the Sec-tRNA isoacceptors occurred in tissues of Se-supplemented rats whereby the unmethylated form gradually shifted toward the methylated form. This was true in each of 4 tissues examined, muscle, kidney, liver and heart, although the rate of redistribution was tissue-specific. Muscle manifested a predominance of 2 minor serine isoacceptors under conditions of extreme Se-deficiency which also appeared to respond to Se. Ribosomal binding studies revealed that 1 of the 2 additional isoacceptors decodes the serine codeword, AGU, and the second decodes the serine codeword, UCU. Interestingly, muscle and heart were the slower tissues to return to a 'Se adequate' tRNA distribution pattern. KW - cysteine KW - deficiency KW - diet KW - heart KW - kidneys KW - liver KW - protein synthesis KW - ribosomes KW - selenium KW - skeletal muscle KW - tissues KW - transfer RNA KW - translation KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - protein biosynthesis KW - RNA translation KW - tRNA KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411793&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 infection in a man homozygous for CCR5Δ32. AU - O'Brien, T. AU - Winkler, C. AU - Dean, M. AU - Nelson, J. A. E. AU - Carrington, M. AU - Michael, N. L. AU - White, G. C. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1997/// IS - 9060 SP - 1219 EP - 1219 SN - 0140-6736 AD - O'Brien, T.: Viral Epidemiology Branch and Laboratory of Genomic Diversity, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Bethesda, MD 20852, USA. N1 - Accession Number: 19972010434. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 113189-02-9, 30516-87-1. N2 - A patient is described who was homozygous for CCR5Δ32, but nonetheless became infected with HIV-1. A white man, born in 1969 with severe haemophilia A, received over 500 000 units of Factor VIII concentrate from 1978 through 1984. He was positive for antibodies to HIV-1 at initial testing in 1985. He also had chronic hepatitis B virus antigenaemia and hepatitis C viraemia. His CD4 lymphocyte count was low (522/µl) in 1983 and fell to 158/µl by 1986. His count continued to fall (despite treatment with zidovudine beginning in 1989), but he had no HIV-1-associated conditions until oral hairy leukoplakia was diagnosed in 1983. He developed AIDS (oesophageal candidiasis) in 1985 and died of liver failure in 1996. KW - acquired immune deficiency syndrome KW - antibodies KW - antigenaemia KW - CD4 antigens KW - chronic course KW - concentrates KW - factor VIII KW - haemophilia KW - hepatitis KW - hepatitis B KW - hepatitis C KW - infection KW - liver KW - lymphocytes KW - oral hairy leukoplakia KW - treatment KW - zidovudine KW - hepatitis B virus KW - Human immunodeficiency virus 1 KW - viruses KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - AIDS KW - antigenemia KW - AZT KW - CD4 KW - hemophilia KW - human immunodeficiency virus type 1 KW - protein feeds KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010434&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of human caliciviruses in epidemic gastroenteritis. AU - Green, K. Y. A2 - Kaaden, O. R. A2 - Czerny, C. P. A2 - Eichhorn, W. JO - Archives of Virology, Supplement JF - Archives of Virology, Supplement Y1 - 1997/// IS - Suppl. 13 SP - 153 EP - 165 SN - 3211830146 AD - Green, K. Y.: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 129, Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19982009347. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - The clinical features and transmission of epidemic gastroenteritis caused by Norwalk virus is discussed, as are research obstacles in the study of human caliciviruses, recent molecular biological approaches for the study of the human caliciviruses, and new epidemiological studies using recombinant protein-based assays. KW - clinical aspects KW - disease transmission KW - epidemics KW - epidemiology KW - foodborne diseases KW - gastroenteritis KW - gastrointestinal diseases KW - human diseases KW - identification KW - phylogenetics KW - reviews KW - viral diseases KW - waterborne diseases KW - Caliciviridae KW - man KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009347&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Human parvovirus B19 infections in infants and children. AU - Brown, K. E. AU - Young, N. S. A2 - Aronoff, S. C. T2 - Advances in pediatric infectious diseases: Volume 13. JO - Advances in pediatric infectious diseases: Volume 13. JF - Advances in pediatric infectious diseases: Volume 13. Y1 - 1997/// SP - 101 EP - 126 CY - St Louis, MO; USA PB - Mosby-Year Book, Inc. SN - 0815109601 AD - Brown, K. E.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982012800. Publication Type: Miscellaneous. Language: English. Number of References: 119 ref. KW - children KW - clinical aspects KW - control KW - diagnosis KW - disease prevention KW - disease transmission KW - epidemiology KW - human diseases KW - immune response KW - infants KW - meningitis KW - pathogenesis KW - reviews KW - viral diseases KW - man KW - Parvovirus B19 KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Parvovirus KW - Parvoviridae KW - ssDNA viruses KW - DNA viruses KW - viruses KW - clinical picture KW - immunity reactions KW - immunological reactions KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012800&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Anti-HIV nucleosides: past, present and future. AU - Johns, D. G.\Welles, L.\Yarchoan, R.\Gu Zhengxian\Wainberg, M. A.\Shafer, R. W.\Merigan, T. C. A2 - Mitsuya, H. T2 - Anti-HIV nucleosides: past, present and future. Y1 - 1997/// CY - Georgetown; USA PB - R. G. Landes Company SN - 354061950X AD - Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19972005641. Publication Type: Book. Language: English. N2 - This book is divided into 5 chapters. The first, discusses the antiretroviral activity of nucleoside analogues; chapter 2 describes their pharmacology; chapter 3 focuses on therapy of HIV-1 infection with antiretroviral nucleosides; drug resistance is covered by chapter 4; and chapter 5 discusses combination therapy with nucleoside analogue reverse transcriptase inhibitors. KW - analogues KW - antiviral agents KW - drug resistance KW - drug therapy KW - enzyme inhibitors KW - HIV-1 infections KW - human diseases KW - metabolism KW - nucleoside analogues KW - nucleosides KW - pharmacology KW - reverse transcriptase inhibitors KW - treatment KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - chemotherapy KW - human immunodeficiency virus type 1 KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005641&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Current approaches to diagnosis and treatment of candidiasis in children. AU - Walsh, T. J. A2 - Aly, R. A2 - Beutner, K. R. A2 - Maibach, H. T2 - Cutaneous infection and therapy. Y1 - 1997/// CY - New York; USA PB - Marcel Dekker Inc. SN - 0824798260 AD - Walsh, T. J.: Pediatric Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981201334. Publication Type: Book chapter. Language: English. Number of References: 114 ref. KW - antifungal agents KW - blood KW - candidosis KW - children KW - clinical aspects KW - diagnosis KW - drug therapy KW - human diseases KW - infants KW - infections KW - reviews KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - candidiasis KW - chemotherapy KW - clinical picture KW - fungistats KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201334&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The role of peroxisome proliferator activated receptor α in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis. AU - Gonzalez, F. J. T2 - Dietary fat and cancer: genetic and molecular interactions. Y1 - 1997/// CY - New York; USA PB - Plenum Publishing Corporation SN - 0306456834 AD - Gonzalez, F. J.: Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19981412924. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 110 ref. Subject Subsets: Human Nutrition N2 - The role of peroxisome proliferator-activated receptor α in carcinogenesis is reviewed under the headings: peroxisomes and peroxisome proliferation; The peroxisome proliferator-activated receptor (PPAR); Function of PPARs; Mechanism of gene activation by PPARα; Peroxisome proliferator-induced hepatocarcinogenesis; species differences and human risk assessment; The PPARα-null mouse; Isolation and characterization of the PPARα cDNA; Production of the PPARα-null mouse; Lipid metabolism in the PPARα-null mouse; The role of PPARα in dehydroepiandrosterone induction of peroxisome proliferation; PPARα and growth control; PPARα and peroxisome proliferation; PPARα and the mechanism of action of non-genotoxic carcinogens; and PPARα and species differences in response to peroxisome proliferators. KW - animal models KW - carcinogens KW - genotoxicity KW - lipid metabolism KW - neoplasms KW - peroxisomes KW - receptors KW - reviews KW - species differences KW - USA KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - fat metabolism KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412924&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Infectious diseases in immunocompromised hosts. AU - Georgiev, V. S. T2 - Infectious diseases in immunocompromised hosts. Y1 - 1997/// CY - Boca Raton; USA PB - CRC Press Inc. SN - 0849385539 AD - Georgiev, V. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982006246. Publication Type: Book. Language: English. Subject Subsets: Public Health; Tropical Diseases; Protozoology; Helminthology N2 - The sections covered and discussed in this book are: viral infections (Herpesviridae, Papovaviridae, Adenoviridae, Parvoviridae, Paramyxoviridae, Poxviridae and Hepadnaviridae) ; bacterial infections (Actinomycetes, Enterobacteriaceae, Campylobacter spp., non-cholera Vibrio spp., Listeria monocytogenes, gastrointestinal infections in the immunocompromised host, Neisseriaceae, Pseudomonadaceae, Rickettsiaceae, Alcaligenaceae, Leuconostoc spp., Treponema pallidum and Mycoplasma spp.); parasitic infections (Eucoccidiorida, Microsporidia, Leishmania spp., Strongyloides stercoralis, Cyclospora spp. and arthropod infestations in HIV-infected patients); and fungal infections (fungal cell envelope and mode of action of antimycotic agents, Deuteromycota (fungi imperfecti), Cryptococcus neoformans, Candida spp., Malassezia (Pityrosporum) spp., Trichosporon beigelii, Rhodotorula spp., other yeast-like fungi, fungi of the order Moniliales, Zygomycota, and Pneumocystis carinii). KW - bacterial diseases KW - helminths KW - HIV infections KW - human diseases KW - immunocompromised hosts KW - infectious diseases KW - microsporidiosis KW - mycoses KW - opportunistic infections KW - parasites KW - protozoal infections KW - viral diseases KW - yeasts KW - Actinomycetales KW - Adenoviridae KW - Alcaligenes KW - arthropods KW - Campylobacter KW - Candida KW - Cryptococcus neoformans KW - Cyclospora KW - Deuteromycotina KW - Enterobacteriaceae KW - Hepadnaviridae KW - Herpesviridae KW - Leishmania KW - Leuconostoc KW - Listeria monocytogenes KW - Malassezia KW - man KW - Microspora KW - Mycoplasma KW - Neisseriaceae KW - Paramyxoviridae KW - Parvoviridae KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Poxviridae KW - Protozoa KW - Pseudomonadaceae KW - Rhabditida KW - Rhodotorula KW - Rickettsiaceae KW - Strongyloides stercoralis KW - Treponema pallidum KW - Trichosporon beigelii KW - Vibrio KW - Zygomycota KW - fungi KW - eukaryotes KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Alcaligenaceae KW - Burkholderiales KW - Betaproteobacteria KW - Proteobacteria KW - invertebrates KW - animals KW - Campylobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Eimeriidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - Enterobacteriales KW - Gammaproteobacteria KW - DNA Reverse Transcribing Viruses KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Leuconostocaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Listeria KW - Listeriaceae KW - Bacillales KW - Malasseziales KW - Ustilaginomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Mycoplasmataceae KW - Mycoplasmatales KW - Mollicutes KW - Neisseriales KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - ssDNA viruses KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Pseudomonadales KW - Sporidiobolales KW - Microbotryomycetes KW - Pucciniomycotina KW - Rickettsiales KW - Alphaproteobacteria KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - Treponema KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Trichosporon KW - Trichosporonaceae KW - Vibrionaceae KW - Vibrionales KW - Zygomycota KW - bacterial infections KW - bacterioses KW - bacterium KW - communicable diseases KW - fungus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - nematodes KW - Papovaviridae KW - parasitic worms KW - protozoal diseases KW - Secernentea KW - viral infections KW - Zygomycotina KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006246&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS. A2 - Taylor, C. E. T2 - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS. Y1 - 1997/// CY - New York; USA PB - Haworth Press Inc. SN - 0789000199 AD - Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA. N1 - Accession Number: 19981405160. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition N2 - The book is divided into eight chapters entitled: nutritional determinants of resistance to tuberculosis; effects of protein calorie malnutrition on mice infected with BCG; vitamin A nutritional status - relationship to the infection and the antibody response; modulation of phagocyte function by nutrition in human immunodeficiency virus (HIV)-1 infection; malnutrition as a co-factor in HIV disease; clinical aspects of nutrition in tuberculosis; malnutrition and acquired immune deficiency syndrome (AIDS) in the developing world; and tuberculosis and the nutritionally disadvantaged - conclusions. KW - acquired immune deficiency syndrome KW - human immunodeficiency viruses KW - immunity KW - infectious diseases KW - malnutrition KW - nutritional disorders KW - tuberculosis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - communicable diseases KW - human immunodeficiency virus KW - Nutritional abnormalities in infectious diseases: effects on tuberculosis and AIDS KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981405160&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Care and maintenance of phlebotomine sandfly colonies. AU - Modi, G. B. A2 - Crampton, J. M. A2 - Beard, C. B. A2 - Louis, C. T2 - The molecular biology of insect disease vectors: a methods manual. Y1 - 1997/// CY - London; UK PB - Chapman & Hall Ltd SN - 0412736608 AD - Modi, G. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980504330. Publication Type: Book chapter. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology KW - laboratory rearing KW - maintenance KW - rearing techniques KW - Diptera KW - Lutzomyia KW - Phlebotominae KW - Phlebotomus KW - Psychodidae KW - Sergentomyia KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Other Invertebrate Culture (Not Aquaculture) (LL030) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. AU - Chuang, R. S. I. AU - Jaffe, H. AU - Cribbs, L. AU - Perez-Reyes, E. AU - Swartz, K. J. JO - Nature Neuroscience JF - Nature Neuroscience Y1 - 1998/// VL - 1 IS - 8 SP - 668 EP - 674 AD - Chuang, R. S. I.: Molecular Physiology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 2C19, 36 Convent Drive, MSC 4066, Bethesda, MD 20892, USA. N1 - Accession Number: 19990504761. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The biophysical properties of T-type voltage-gated calcium channels are well suited to pacemaking and to supporting calcium flux near the resting membrane potential in both excitable and non-excitable cells. A new scorpion toxin (kurtoxin) from Parabuthus transvaalicus that binds to the α1G T-type calcium channel with high affinity and inhibits the channel by modifying voltage-dependent gating was identified. This toxin distinguishes between α1G T-type calcium channels and other types of voltage-gated calcium channels, including α1A, α1B, α1C, and α1E. Like the other α-scorpion toxins to which it is related, kurtoxin also interacts with voltage-gated sodium channels and slows their inactivation. It is hypothesised that kurtoxin will facilitate characterization of the subunit composition of T-type calcium channels and help determine their involvement in electrical and biochemical signalling. KW - calcium channels KW - ion channels KW - ion transport KW - mode of action KW - toxins KW - Arachnida KW - Buthidae KW - Scorpiones KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Scorpiones KW - Arachnida KW - Buthidae KW - kurtoxin KW - Parabuthus KW - Parabuthus transvaalicus KW - toxinology KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduction in SIV replication in rhesus macaques infused with autologous lymphocytes engineered with antiviral genes. AU - Donahue, R. E. AU - Bunnell, B. A. AU - Zink, M. C. AU - Metzger, M. E. AU - Westro, R. P. AU - Kirby, M. R. AU - Unangst, T. AU - Clements, J. E. AU - Morgan, R. A. JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 2 SP - 181 EP - 186 AD - Donahue, R. E.: Clinical Gene Therapy Branch, National Human Genome Research Institute, NIH, B.dg 10, Rm 10C103, 10 Center Drive, Bethesda, MD 20892-1851, USA. N1 - Accession Number: 19982004291. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - To test a potential anti-HIV gene therapy strategy in the SIV animal model of HIV infection, CD4+ cell-enriched lymphocytes from 3 rhesus macaques were subjected to retrovirally mediated gene transfer with a vector expressing an antisense tat/rev gene. This group of animals and 3 control macaques were subsequently infected with SIVmac239. Blood and lymph nodes from all macaques were sampled for more than a year to monitor the progress of infection. Although all animals became infected, the animals that received the lymphocytes engineered with the antisense vector demonstrated a significant reduction in viral load in both peripheral blood and lymph nodes, had sustained numbers of CD4+ cells, and exhibited little disruption of lymph-node architecture. KW - animal models KW - antiviral agents KW - CD4+ lymphocytes KW - disease vectors KW - gene transfer KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - lymph nodes KW - lymphocytes KW - replication KW - vectors KW - viral load KW - Macaca KW - Macaca mulatta KW - man KW - simian immunodeficiency virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Macaca KW - Homo KW - Hominidae KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004291&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency. AU - Glushakova, S. AU - Grivel, J. C. AU - Fitzgerald, W. AU - Sylwester, A. AU - Zimmerberg, J. AU - Margolis, L. B. JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 3 SP - 346 EP - 349 AD - Glushakova, S.: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development NIH, Bldg 10, Rm 10D14, 10 Center Drive, Bethesda, MD 20892-1855, USA. N1 - Accession Number: 19982004437. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear. Initial infection with HIV-1 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the immune system, and, in one view, cause immunodeficiency by "exhaustion" of lymphoid tissue. An alternative hypothesis is that immunodeficiency is caused by the replacement of M-tropic viruses by T-cell (T)-tropic/syncytia-inducing (SI) viruses, which are known to be highly cytopathic in vitro and emerge late in infected individuals around the time of transition to AIDS. To test these 2 possibilities, an ex vivo model of humoral immunity to recall antigens was developed using human lymphoid tissue. This tissue supports productive infection with both M- and T-tropic HIV-1 isolates when cultured ex vivo. It was found that specific immune responses were enhanced by productive infection of the tissue with M-tropic/NSI HIV-1 isolates, but were blocked by T-tropic/SI HIV-1 isolates. The mechanism involves specific irreversible effect on B-cell activity. These results support the hypothesis that the phenotype switch to T-tropic viruses is a key determinant of acquired humoral immunodeficiency in patients infected with HIV. KW - acquired immune deficiency syndrome KW - antigens KW - B lymphocytes KW - effects KW - human diseases KW - humoral immunity KW - immune response KW - immunity KW - immunopathology KW - in vitro KW - infection KW - macrophages KW - pathogenesis KW - patients KW - phenotypes KW - syncytia KW - T lymphocytes KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - antigenicity KW - B cells KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunogens KW - immunological reactions KW - immunopathogenesis KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004437&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - New and reemerging diseases: the importance of biomedical research. AU - Fauci, A. S. JO - Emerging Infectious Diseases JF - Emerging Infectious Diseases Y1 - 1998/// VL - 4 IS - 3 SP - 374 EP - 378 AD - Fauci, A. S.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990502303. Publication Type: Journal Article. Language: English. Number of References: 8 ref. KW - emerging infectious diseases KW - human diseases KW - infectious diseases KW - research KW - communicable diseases KW - emerging diseases KW - emerging infections KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502303&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Synergistic effects of 8-Chlorocyclic-AMP and retinoic acid on induction of apoptosis in ewing's sarcoma CHP-100 cells. AU - Srivastava, R. K. AU - Srivastava, A. R. AU - Yoon, S. C. C. JO - Clinical Cancer Research JF - Clinical Cancer Research Y1 - 1998/// VL - 4 IS - 3 SP - 755 EP - 761 AD - Srivastava, R. K.: Cellular Biochemistry Section, Laboratory of Tumor Immunology, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19981408801. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - The enhanced expression of the regulatory subunit of cyclic AMP (cAMP)-dependent protein kinase type I, RIα, has been correlated with cancer cell growth. Retinoic acid (RA) has been shown to play an important role in the regulation of proliferation and differentiation in neoplastic cells. This study examined the effects of cAMP analogue 8-chlorocyclic-AMP (8-CI-cAMP) and RA (both singly and combined) on growth inhibition and apoptosis in Ewing's sarcoma CHP-100 cells were evaluated. The inhibitory effects of 8-CI-cAMP and RA (9-cis-RA, 13-cis-RA and all-trans-RA) on cell viability were time and dose related. The degree of growth inhibition induced by 9-cis-RA was the greatest among all of the RA analogues (13-cis-RA and all-trans-RA) examined. The combined effects of 8-Cl-cAMP and RA on the induction of growth arrest at the G0-G1 stage of the cell cycle, apoptosis, down-regulation of RIα and cleavage of poly(ADP-ribose) polymerase were synergistic. It was concluded that RA and 8-Cl-cAMP act in a synergistic fashion and have potential for combination chemotherapy for the treatment of malignant disease. KW - antineoplastic agents KW - drug therapy KW - neoplasms KW - retinoic acid KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - chemotherapy KW - cytotoxic agents KW - tretinoin KW - vitamin A acid KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408801&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Genetic effects on HIV disease progression. AU - Ionnidis, J. P. A. AU - O'Brien, T. R. AU - Rosenberg, P. S. AU - Contopoulos-Ioannidis, D. G. AU - Goedert, J. J. T2 - Nature Medicine JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 5 SP - 536 EP - 536 AD - Ionnidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA. N1 - Accession Number: 19982007269. Publication Type: Correspondence. Language: English. Number of References: 6 ref. N2 - The controversy surrounding the effect of specific chemokine receptor polymorphisms on HIV disease progression highlights the need for synthesis of the pertinent evidence. It also suggests that large-scale international collaborations are indispensable when it comes to addressing important questions in the field. An international meta-analysis of HIV host genetics is proposed. The meta-analysis is sponsored by the HIV/AIDS Collaborative Review Group of the International Cochrane Collaboration. The Collaboration's principles of being systematic, all-inclusive and objective benefit this rapidly growing field. For further details contact: ji24m@NIH.gov. KW - acquired immune deficiency syndrome KW - chemokines KW - cytokines KW - disease course KW - genetic variation KW - human diseases KW - human immunodeficiency viruses KW - receptors KW - resistance KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - disease progression KW - genetic variability KW - genotypic variability KW - genotypic variation KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007269&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemokines and HIV-2 second receptors: the therapeutic connection. AU - Cairns, J. S. AU - D'Souza, M. P. JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 5 SP - 563 EP - 568 AD - Cairns, J. S.: Pathogenesis and Basic Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Bldg. 2C35, Bethesda, MD 20892,USA. N1 - Accession Number: 19982007270. Publication Type: Journal Article. Language: English. Number of References: 76 ref. KW - chemokines KW - cytokines KW - pathogenesis KW - receptors KW - uptake KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007270&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein. AU - Bera, T. K. AU - Kennedy, P. E. AU - Berger, E. A. AU - Barbas, C. F. III AU - Pastan, I. JO - Molecular Medicine JF - Molecular Medicine Y1 - 1998/// VL - 4 IS - 6 SP - 384 EP - 391 AD - Bera, T. K.: Laboratory of Molecular Biology, National Cancer Institute, NIH, Bldg 37, Rm 4E16, 37 Convent Drive, MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982010891. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9007-49-2. N2 - Recombinant DNA technology was used to clone the Fv fragment of 3B3 (a high-affinity anti-gp120 antibody) and produce a single chain Fv (scFv). 3B3 scFv was then fused to a truncated version of Pseudomonas exotoxin A (PE38), giving rise to a recombinant immunotoxin 3B3(Fv)-PE38 that was expressed in E. coli and purified to near homogeneity. 3B3 (Fv)-PE38 binds with the same affinity as the parental Fab antibody to the MN strain of gp120. The immunotoxin specifically kills a gp120-expressing transfected cell line and a chronically HIV-infected lymphocytic cell line. The immunotoxin is very stable at 37°C, retaining 80% of its original activity after 24 hr. KW - antibodies KW - antiviral agents KW - cell lines KW - clones KW - DNA KW - envelope glycoproteins KW - envelope protein gp120 KW - exotoxins KW - glycoproteins KW - human diseases KW - human immunodeficiency viruses KW - immunotherapy KW - lymphocytes KW - recombinant DNA KW - Human immunodeficiency virus 1 KW - man KW - Pseudomonas KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pseudomonadaceae KW - Pseudomonadales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - deoxyribonucleic acid KW - exotoxin A KW - gp120 KW - homogeneity KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010891&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Peripheral expansion of preexisting mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. AU - Walker, R. E. AU - Carter, C. S. AU - Muul, L. AU - Natarajan, V. AU - Herpin, B. R. AU - Leitman, S. F. AU - Klein, H. G. AU - Mullen, C. A. AU - Metcalf, J. A. AU - Baseler, M. AU - Falloon, J. AU - Davey, R. T. Jr. AU - Kovacs, J. A. AU - Polis, M. A. AU - Masur, H. AU - Blaese, R. M. AU - Lane, H. C. JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 7 SP - 852 EP - 856 AD - Walker, R. E.: Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 11S231, NIH Bethesda, MD 20892, USA. N1 - Accession Number: 19982012104. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - The CD4+ T-cell pool in HIV-infected patients is in a constant state of flux as CD4+ T cells are infected and destroyed by HIV and new cells take their place. To study T-cell survival, peripheral blood lymphocytes transduced with the neomycin phosphotransferase gene were adoptively transduced between syngeneic twin pairs discordant for HIV infection. A stable fraction of marked CD4+ T cells persisted in the circulation of 4 to 18 weeks after transfer in all patients. After this time there was a precipitous decline in marked cells in 3 of the patients. At ~6 months, marked cells were in lymphoid tissues in proportions comparable to those found in peripheral blood. In two patients, the proportion of total signal for the transgene (found by PCR analysis) in the CD4/CD45RA+ T-cell population relative to the CD4/CD45RO+ population increased in the weeks after cell infusion. These findings indicate that genetically-marked CD4+ T cells persist in vivo for weeks to months and that the CD4+ T-cell pool in adults is maintained mostly by the division of mature T cells rather than by differentiation of prethymic stem cells. Thus, after elements of the T-cell repertoire are lost through HIV infection, they may be difficult to replace. KW - CD4+ lymphocytes KW - differentiation KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - lymphocyte transformation KW - survival KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012104&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection. AU - Sanjay Gurunathan AU - Prussin, C. AU - Sacks, D. L. AU - Seder, R. A. JO - Nature Medicine JF - Nature Medicine Y1 - 1998/// VL - 4 IS - 12 SP - 1409 EP - 1415 AD - Sanjay Gurunathan: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990805747. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology N2 - Mice vaccinated either with Leishmania major protein and recombinant interleukin-12 (rIL-12), or with plasmid DNA encoding the protein, controlled footpad swelling when infected 2 weeks later with L. major, but when the challenge was given after 12 weeks, only those vaccinated with the DNA controlled the infection. rIL-12 in combination with other antigens was no more effective than with this protein. Experiments using a different protein showed that leishmanial protein plus IL-12 DNA produced an immunity that lasted much longer than that elicited by leishmanial protein plus IL-12 protein. Lymph nodes from mice which were still capable of controlling infection produced interferon-γ, but those from mice which were no longer immune did not. Treatment with anti-IL-12 antibody abrogated immunity. It is concluded that the persistence of IL-12 may be the essential determinant in maintaining durable cell-mediated immune responses against intracellular parasitic infection. KW - animal diseases KW - antigens KW - cell mediated immunity KW - DNA vaccines KW - experimental infections KW - human diseases KW - immune response KW - immunity KW - immunization KW - interleukin 12 KW - interleukins KW - intracellular parasitism KW - laboratory animals KW - leishmaniasis KW - parasites KW - plasmid vectors KW - recombinant proteins KW - recombinant vaccines KW - vaccination KW - vaccines KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - antigenicity KW - cellular immunity KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - leishmaniosis KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805747&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-dendritic cell interactions promote efficient viral infection of T cells. AU - Zoeteweij, J. P. AU - Blauvelt, A. JO - Journal of Biomedical Science JF - Journal of Biomedical Science Y1 - 1998/// VL - 5 IS - 4 SP - 253 EP - 259 AD - Zoeteweij, J. P.: Dermatology Branch, National Cancer Institute, Bldg 10, Rm 12N238, 10 Center Dr., MSC 1908, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19982011108. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - HIV-dendritic cell (DC) interactions may promote efficient viral infection of T cells in a variety of settings and disease stages. Future studies will likely focus on the role of DCs in animal and organ culture models of primary HIV infection. Additionally, blocking HIV-DC interactions during both acute and chronic HIV disease may become an important therapeutic strategy for blocking infection and depletion of T cells. KW - chemokines KW - chronic course KW - cytokines KW - dendritic cells KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - pathogenesis KW - receptors KW - reviews KW - T lymphocytes KW - viral diseases KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Langerhans cells KW - T cells KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011108&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - And the best picture is-the HIV gp120 envelope, please! AU - Berger, E. A. JO - Nature Structural Biology JF - Nature Structural Biology Y1 - 1998/// VL - 5 IS - 8 SP - 671 EP - 674 SN - 1072-8368 AD - Berger, E. A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bldg 4, Rm 236, Bethesda, MD 20892, USA. N1 - Accession Number: 19982012099. Publication Type: Journal Article. Language: English. Number of References: 11 ref. N2 - Investigation of the X-ray crystallographic structure of the gp120 core coupled with mutagenesis analyses reveal details of receptor interactions and multiple layers of immune evasion. KW - chemokines KW - cytokines KW - envelope protein gp120 KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - receptors KW - structure KW - X ray crystallography KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - gp120 KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012099&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fatty acid metabolism in mitochondria: Defects and genetics. AU - Coates, P. M. JO - BioFactors JF - BioFactors Y1 - 1998/// VL - 7 IS - 3 SP - 201 EP - 202 AD - Coates, P. M.: Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981408077. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition KW - defects KW - fatty acids KW - genetic disorders KW - ketogenesis KW - lipid metabolism KW - metabolism KW - mitochondria KW - oxidation KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - fat metabolism KW - genetic defects KW - hereditary defects KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408077&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Impact of ofloxacin used prophylactically in neutropenic patients on development of resistance. AU - Spanik, S. AU - Studena, M. AU - Sykora, J. AU - Kunova, A. AU - Trupl, J. AU - Pichna, P. AU - Demitrovicova, A. AU - Kralovicova, K. AU - Grey, E. AU - Kukuckova, E. AU - Koren, P. AU - Krcmery, V., Jr. JO - Infectious Diseases in Clinical Practice JF - Infectious Diseases in Clinical Practice Y1 - 1998/// VL - 7 IS - 4 SP - 199 EP - 202 SN - 1056-9103 AD - Spanik, S.: Department of Medicine, Pharmacology, and Microbiology, National Cancer Institute, Bratislava, Slovakia. N1 - Accession Number: 19992005900. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 82419-36-1. N2 - The association between use of ofloxacin as prophylaxis for febrile neutropenia and incidence of Gram-negative bacteraemia and resistance development in Enterobacteriaceae and Pseudomonas aeruginosa was studied in a national referral cancer centre in Bratislava, Slovakia. Despite increasing use of ofloxacin, from 0 g/year in 1990 to 2350 g/year in 1996, no increase in resistance in Enterobacteriaceae was observed. The overall incidence of resistance to quinolones was 2.8%. Only 2 ofloxacin-resistant Escherichia coli strains were observed within 8 years. However, the incidence of resistance by P. aeruginosa against ofloxacin during the observation period was 6.4%-21.0%. It is concluded that increasing use of ofloxacin did not cause significant changes in resistance within the previous 8 years in Gram-negative bacilli, with the exception of Acinetobacter spp. KW - bacteraemia KW - drug resistance KW - Gram negative bacteria KW - human diseases KW - immunocompromised hosts KW - neoplasms KW - neutropenia KW - ofloxacin KW - opportunistic infections KW - prophylaxis KW - quinolones KW - Slovakia KW - Acinetobacter KW - Bacteria KW - Enterobacteriaceae KW - Escherichia coli KW - man KW - Pseudomonas aeruginosa KW - Bacteria KW - prokaryotes KW - Moraxellaceae KW - Pseudomonadales KW - Gammaproteobacteria KW - Proteobacteria KW - Enterobacteriales KW - Escherichia KW - Enterobacteriaceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pseudomonas KW - Pseudomonadaceae KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - bacteremia KW - bacterium KW - cancers KW - E. coli KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005900&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A survey of human papillomavirus 16 antibodies in patients with epithelial cancers. AU - Strickler, H. D. AU - Schiffman, M. H. AU - Shah, K. V. AU - Rabkin, C. S. AU - Schiller, J. T. AU - Wacholder, S. AU - Clayman, B. AU - Viscidi, R. P. JO - European Journal of Cancer Prevention JF - European Journal of Cancer Prevention Y1 - 1998/// VL - 7 IS - 4 SP - 305 EP - 313 SN - 0959-8278 AD - Strickler, H. D.: National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, Room 434, Rockville, MD 20852, USA. N1 - Accession Number: 19982013262. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health N2 - To assess exposure to human papillomavirus (HPV) 16 in patients with different cancers, a large serosurvey of 905 patients from Minnesota, USA, with 21 types of tumours was conducted, and IgG to HPV 16 virus-like particles were measured using a well characterized ELISA. The specimens tested were collected by a serum bank between 1975 and 1991. Patients with cervical cancer were considered 'positive controls', as about half were expected to be specifically HPV 16-related. A non-cancer study group consisting of 48 patients with endocrine disorders (e.g. diabetes) was also tested. HPV 16 antibody prevalence was highest in patients with cancers of the cervix (52±7%), vulva (27±9%), vagina (27±13%) and penis (63±16%). Seroprevalence was much lower in the non-cancer group (4±3%) and all other cancer patients: uterus (9±4%); ovary (4±3%); testis (5±4%); prostate (6±4%); squamous carcinoma (6±3%) and adenocarcinoma (4±3%) of the lung; rectum (2±2%); pancreas (8±4%); colon (2±2%); stomach (0%); oesophagus (8±4%); buccal cavity (12±5%); breast (10±4%); non-melanomatous (9±6%) and melanomatous (6±3%) skin tumours; bladder (8±4%); and kidney (2±2%). The results confirm the strong relation of HPV with several lower anogenital tract tumours, but, at least in this population, fail to identify additional epithelial tumours associated with high seroprevalence of HPV 16 VLP antibodies. KW - antibodies KW - carcinoma KW - epidemiology KW - epithelium KW - human diseases KW - IgG KW - neoplasms KW - seroprevalence KW - viral diseases KW - Minnesota KW - USA KW - human papillomavirus 16 KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lake States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Papillomaviridae KW - cancers KW - human papillomavirus KW - Papovaviridae KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013262&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The mosquito dihydrofolate reductase amplicon contains a truncated synaptic vesicle protein gene. AU - Wang, Z. H. AU - Fallon, A. M. JO - Insect Molecular Biology JF - Insect Molecular Biology Y1 - 1998/// VL - 7 IS - 4 SP - 317 EP - 325 SN - 0962-1075 AD - Wang, Z. H.: National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, Bethesda, MD 20892, USA. N1 - Accession Number: 19980504862. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9002-03-3, 59-05-2. Subject Subsets: Medical & Veterinary Entomology N2 - When maintained under continuous selection with the folate inhibitor, methotrexate, cultured Aedes albopictus cells amplify an ~200 kb region of DNA containing the dihydrofolate reductase gene. To determine whether the amplicon contained additional coding regions, Southern blots of cosmid clones containing amplicon DNA were probed separately with reverse-transcribed mRNA from methotrexate-sensitive and methotrexate-resistant cells. Cosmid pWED118 contained 5 EcoRI fragments (A, B, C, F, G) ranging in size from 2 to 5 kb that hybridized with cDNA from resistant cells. Of these, fragments B and F also hybridized to probe representing mRNA from sensitive cells, and all but fragment G hybridized to repetitive DNA from wild-type cells. Fragment G, which appeared to encode a low copy number gene in wild-type cells that subsequently became part of the dihydrofolate reductase amplicon in methotrexate-resistant cells, hybridized strongly to a 7 kb band and more weakly to bands measuring 9 and 3 kb on Northern blots containing RNA from resistant cells. Fragment G contained a 1203 bp open reading frame, encoding 401 amino acids homologous to synaptic vesicle protein SV2, a member of a transmembrane transporter family expressed in neural and endocrine cells. The region of homology included the 6 N-terminal transmembrane domains, an internal cytoplasmic loop, a 7th transmembrane domain, and most of an intravesicular loop. This partial sequence, which appears to correspond to a truncated gene generated during formation of the dihydrofolate reductase amplicon, provides a useful basis for more extensive characterization of an important gene family that may be the target of novel insecticides. KW - amplification KW - cell lines KW - cells KW - dihydrofolate reductase KW - genes KW - genetics KW - inhibitors KW - methotrexate KW - molecular biology KW - molecular genetics KW - nucleotide sequences KW - open reading frames KW - proteins KW - resistance KW - vesicles KW - Aedes albopictus KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - amethopterin KW - amplicons KW - Asian tiger mosquito KW - biochemical genetics KW - DNA sequences KW - mosquitoes KW - ORFs KW - synapses KW - tetrahydrofolate dehydrogenase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504862&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Association between consumption of antibiotics and development of resistance: 8-year experience from a Slovakian cancer center. AU - Sykora, P. AU - Trupl, J. T2 - Infectious Diseases in Clinical Practice JO - Infectious Diseases in Clinical Practice JF - Infectious Diseases in Clinical Practice Y1 - 1998/// VL - 7 IS - 7 SP - 364 EP - 365 SN - 1056-9103 AD - Sykora, P.: Department of Clinical Pharmacology, Microbiology and Pharmacy, National Cancer Institute, St. Elizabeth's Cancer Institute, Bratislava, Slovakia. N1 - Accession Number: 19992007312. Publication Type: Correspondence. Language: English. Number of References: 3 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 1404-90-6, 1404-93-9. KW - ampicillin KW - drug resistance KW - drug therapy KW - human diseases KW - neoplasms KW - penicillins KW - vancomycin KW - Slovakia KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - cancers KW - chemotherapy KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007312&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy. AU - Klebanoff, M. A. AU - Levine, R. J. AU - Dersimonian, R. AU - Clemens, J. D. AU - Wilkins, D. G. JO - Annals of Epidemiology JF - Annals of Epidemiology Y1 - 1998/// VL - 8 IS - 2 SP - 107 EP - 111 SN - 1047-2797 AD - Klebanoff, M. A.: Division of Epidemiology, Statistics, and Preventive Research, National Institute of Child Health and Human Development, NIH, 6100 Bldg Room 7B03, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19981406036. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 58-08-2. Subject Subsets: Human Nutrition N2 - Serum concentrations of caffeine and paraxanthine were determined by HPLC in 60 women with normal pregnancy outcomes who reported consuming ≤ 0.8 mg/kg per day of caffeine in a 24-h dietary recall, 60 who consumed 0.81-2.5 mg/kg per day, 60 who consumed 2.51-5.00 mg/kg per day and 59 who consumed ≥ 5.01 mg/kg per day. The weighted kappa coefficient between strata of caffeine intake and quartiles of serum paraxanthine was 0.58 among smokers and 0.53 among non-smokers, vs. 0.44 and 0.51, respectively, for quartiles of serum caffeine. The Pearson correlation coefficient between intake and paraxanthine was 0.50 for smokers and 0.53 for non-smokers, and 0.37 and 0.51, respectively, for serum caffeine. These values are comparable to the correlation between reported smoking and serum cotinine in pregnancy. It is concluded that serum concentrations of paraxanthine, and to a lesser degree, caffeine are useful to distinguish between women with varying levels of caffeine intake. KW - analytical methods KW - caffeine KW - intake KW - markers KW - pregnancy KW - serum KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - gestation KW - paraxanthine KW - Techniques and Methodology (ZZ900) KW - Diet Studies (VV110) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406036&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Advances in the treatment of chronic hepatitis B virus infection. AU - Marques, A. R. AU - Straus, S. E. JO - Reviews in Medical Virology JF - Reviews in Medical Virology Y1 - 1998/// VL - 8 IS - 4 SP - 223 EP - 234 SN - 1052-9276 AD - Marques, A. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992004245. Publication Type: Journal Article. Language: English. Number of References: 77 ref. N2 - Recent advances in our understanding of the replicative mechanism of HBV, and the development of potent nucleoside analogues as clinically effective inhibitors of the HIV reverse transcriptase or herpesvirus polymerases has opened a new era in the treatment of chronic HBV infection. Single agent therapies, such as famciclovir, lamivudine or lobucavir, have had some success. There is now a logical basis for combination therapy, because of the clear need for prolonged treatment and the associated possibility that drug resistant strains will emerge with monotherapy, but the choice of agents to combine and the regimens in which they should be employed remain uncertain. KW - analogues KW - drug therapy KW - hepatitis B KW - human diseases KW - nucleoside analogues KW - nucleosides KW - reviews KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - chemotherapy KW - nucleoside analogs KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004245&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis. AU - Hallock, Y. F. AU - Cardellina, J. H., II AU - Schäffer, M. AU - Bringmann, G. AU - François, G. AU - Boyd, M. R. JO - Bioorganic & Medicinal Chemistry Letters JF - Bioorganic & Medicinal Chemistry Letters Y1 - 1998/// VL - 8 IS - 13 SP - 1729 EP - 1734 SN - 0960-894X AD - Hallock, Y. F.: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19990801959. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Protozoology N2 - A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A, comprised of 2 different monomeric biaryl halves, was isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum. KW - alkaloids KW - antimalarials KW - antiprotozoal agents KW - antiprotozoal properties KW - in vitro KW - medicinal plants KW - novel antiprotozoal agents KW - parasites KW - plant extracts KW - Cameroon KW - Ancistrocladaceae KW - Ancistrocladus KW - Ancistrocladus korupensis KW - Human immunodeficiency virus 1 KW - Plasmodium falciparum KW - protozoa KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Ancistrocladaceae KW - Ancistrocladus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - anti-protozoal properties KW - drug plants KW - human immunodeficiency virus type 1 KW - korundamine A KW - medicinal herbs KW - naphthylisoquinoline KW - naphthylisoquinoline alkaloid KW - officinal plants KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801959&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Absorption, transport, and disposition of ascorbic acid in humans. AU - Rumsey, S. C. AU - Levine, M. JO - Journal of Nutritional Biochemistry JF - Journal of Nutritional Biochemistry Y1 - 1998/// VL - 9 IS - 3 SP - 116 EP - 130 SN - 0955-2863 AD - Rumsey, S. C.: Molecular and Clinical Nutrition Section, National Institutes of Health, Bethesda, MD 20892-1372, USA. N1 - Accession Number: 19981408365. Publication Type: Journal Article. Language: English. Number of References: 209 ref. Registry Number: 50-81-7, 490-83-5. Subject Subsets: Human Nutrition N2 - A review. KW - absorption KW - ascorbic acid KW - availability KW - dehydroascorbic acid KW - distribution KW - excretion KW - pharmacokinetics KW - tissues KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin C KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408365&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Targeting RNase L to human immunodeficiency virus RNA with 2-5A-antisense. AU - Player, M. R. AU - Maitra, R. K. AU - Silverman, R. H. AU - Torrence, P. F. JO - Antiviral Chemistry & Chemotherapy JF - Antiviral Chemistry & Chemotherapy Y1 - 1998/// VL - 9 IS - 3 SP - 225 EP - 231 SN - 0956-3202 AD - Player, M. R.: Section on Biomedical Chemistry, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA. N1 - Accession Number: 19982014890. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 63231-63-0. N2 - In an attempt to develop a lead for the application of 2-5A-antisense to the targeted destruction of human immunodeficiency virus (HIV) RNA, specific target sequences within the HIV mRNAs were identified by analysis of the theoretical secondary structure. 2-5A-antisense chimeras were chosen against a total of 11 different sequences: three in the gag mRNA, three in the rev mRNA and five in the tat mRNA. 2-5A-antisense chimera synthesis was accomplished using solid-phase phosphoramidite chemistry. These chimeras were evaluated for their activity in a cell-free assay system using purified recombinant human RNase L to effect cleavage of 32P-labelled RNA transcripts of plasmids derived from HIV NL4-3. This screening revealed that of the three 2-5A-antisense chimeras targeted against gag mRNA, only one had significant HIV RNA cleavage activity, approximately 10-fold-reduced compared to the parent 2-5A tetramer and comparable to that reported for the prototypical 2-5A-anti-PKR chimera, targeted against PKR mRNA. The cleavage activity of this chimera was specific, since a scrambled antisense domain chimera and a chimera without the key 5′-monophosphate moiety were both inactive. The 10 other 2-5A-antisense chimeras against tat and rev had significantly less activity. These results imply that HIV gag RNA, like PKR RNA and a model HIV tat-oligoA-vif RNA, can be cleaved using the 2-5A-antisense approach. The results further imply that not all regions of a potential RNA target are accessible to the 2-5A-antisense approach. KW - acquired immune deficiency syndrome KW - chimaeras KW - culture media KW - effects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - messenger RNA KW - plasmids KW - ribonucleases KW - RNA KW - structure KW - synthesis KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cell free media KW - chimeras KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - mRNA KW - ribonucleic acid KW - RNASE KW - solid phase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014890&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for male breast cancer (United States). AU - Hsing, A. W. AU - McLaughlin, J. K. AU - Cocco, P. AU - Chien, H. T. C. AU - Fraumeni, J. F., Jr. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1998/// VL - 9 IS - 3 SP - 269 EP - 275 SN - 0957-5243 AD - Hsing, A. W.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Blvd., Room 443, Bethesda, MD 20892, USA. N1 - Accession Number: 19991401723. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition N2 - A case-control study was conducted to investigate risk factors for breast cancer in men. Based on data from the 1986 National (United States) Mortality Followback Survey (NMFS) of almost 20 000 deceased adults (age 25 years or over), information obtained from next-of-kin interviews of 178 men who died of breast cancer was compared with that of 512 male controls who died of other causes. Information was obtained on selected demographic and other factors, including diet, exercise, occupation, height and weight and use of tobacco and alcohol. Increased risks were found for men who were described by their next-of-kin as very overweight (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-5.0). The risks associated with the 3 upper quartiles of body mass index (BMI) were 1.3, 1.6 and 2.3, respectively, with a significant dose-response relationship (P<0.01). An excess risk was also associated with limited exercise (OR = 1.3, CI = 0.8-2.0). Consumption of red meat was associated with an increased risk and consumption of fruits and vegetables with a decreased risk, although the trends were not significant. No association was found for tobacco or alcohol use, but an excess risk was associated with higher levels of socioeconomic status (OR = 1.8, CI = 1.1-3.0). The study suggests that obesity increases the risk of male breast cancer, possibly through hormonal mechanisms, while dietary factors, physical activity and SES indicators also play a part. KW - alcohol intake KW - anthropometric dimensions KW - body weight KW - diet KW - diet studies KW - fruit KW - lifestyle KW - mammary gland neoplasms KW - mammary glands KW - men KW - mortality KW - neoplasms KW - obesity KW - occupations KW - physical activity KW - risk KW - risk factors KW - tobacco smoking KW - vegetables KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - alcohol consumption KW - anthropometric measurements KW - cancers KW - death rate KW - fatness KW - mammary tumour KW - United States of America KW - vegetable crops KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401723&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions. AU - Smith, M. A. AU - Simon, R. AU - Strickler, H. D. AU - McQuillan, G. AU - Ries, L. A. G. AU - Linet, M. S. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1998/// VL - 9 IS - 3 SP - 285 EP - 298 SN - 0957-5243 AD - Smith, M. A.: Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19992001481. Publication Type: Journal Article. Language: English. Number of References: 115 ref. N2 - Infection patterns for hepatitis A virus (HAV) were used to indicate hygiene conditions in different populations, with emphasis on instructive USA and Japanese data. A catalytic model was fitted to these data, estimating the HAV force of infection and age-specific seroprevalence rates over time. These analyses were used to assess the temporal relationship of changes in HAV infection rates to changes in childhood leukaemia mortality and incidence rates. An inverse relationship was observed between HAV infection prevalence and rates of childhood leukaemia. Further, decreases in the HAV force of infection in the USA and Japan appeared to have preceded increases in childhood leukaemia rates. A model is described based on a putative leukaemia-inducing agent with a change in infection rate over time correlated with that of HAV that describes the temporal trends in childhood leukaemia rates for white children in the US and for Japanese children. It is suggested that improved public hygiene conditions, as measured by decreased prevalence of HAV infection, are associated with higher childhood acute lymphoblastic leukaemia (ALL) incidence rates. The model presented supports the plausibility of the hypothesis that decreased childhood exposure to a leukaemia-inducing agent associated with hygiene conditions leads to higher rates of ALL in children by increasing the frequency of in utero transmission caused by primary infection during pregnancy (or by increasing the number of individuals infected in early infancy because of lack of protective maternal antibodies). KW - children KW - epidemiology KW - hepatitis A KW - human diseases KW - hygiene KW - incidence KW - neoplasms KW - Japan KW - USA KW - hepatitis A virus KW - man KW - Hepatovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - North America KW - America KW - acute lymphoblastic leukaemia KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001481&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary exposure models for nitrates and nitrites. AU - Pennington, J. A. T. JO - Food Control JF - Food Control Y1 - 1998/// VL - 9 IS - 6 SP - 385 EP - 395 SN - 0956-7135 AD - Pennington, J. A. T.: Division of Nutrition Research Coordination, National Institutes of Health, Natcher Building, Room 5AN32A, 45 Center Drive, Bethesda, MD 20892-6600, USA. N1 - Accession Number: 19981418766. Publication Type: Journal Article. Language: English. Number of References: 122 ref. Registry Number: 14797-55-8. Subject Subsets: Human Nutrition N2 - Models to assess dietary exposure of population groups to nitrates and nitrites should be based on the major sources of these substances in foods. Most models require the use of food consumption information and will, therefore, be flawed by the problems that exist with current dietary intake assessment methods. The Total Diet Study model would probably not provide representative coverage of the nitrites in processed meats. A nitrate/nitrite database model requires the gathering and compiling of published data and data from industry on the nitrate and nitrite content of foods. A nitrate/nitrite core food model requires the identification of the foods most responsible for nitrate/nitrite consumption in the U.S. and routine collection and analyses of these products. The large database model uses the database of a national food consumption survey and assigns nitrate and nitrite values to all the foods (based on available data and imputation). A processed meat production/consumption model focuses only on nitrites added to processed, cured meats. The nitrate/nitrite core food model is the preferred approach. KW - analytical methods KW - consumption KW - diet KW - estimation KW - exposure KW - food contamination KW - foods KW - intake KW - mathematical models KW - meat products KW - models KW - nitrate KW - nitrates KW - nitrite KW - nitrites KW - sources KW - surveys KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - food contaminants KW - Human Nutrition (General) (VV100) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418766&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 2 lentivirus vectors for gene transfer: expression and potential for helper virus-free packaging. AU - Arya, S. K. AU - Zamani, M. AU - Kundra, P. JO - Human Gene Therapy JF - Human Gene Therapy Y1 - 1998/// VL - 9 IS - 9 SP - 1371 EP - 1380 SN - 1043-0342 AD - Arya, S. K.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, NIH 37 Convent Drive MSC 4255, Bldg 37, Rm 6A11, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982010711. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 63231-63-0. N2 - HIV-2 lentivirus contains elements in its leader sequence located both upstream and downstream of the splice donor sites that participate in RNA encapsidation. These elements appeared to be necessary and sufficient for packaging. Deletion of both upstream and downstream elements was clearly beneficial for curtailing helper virus protection, although this was accompanied by some but acceptable loss of expression capability. The helper virus-free phenotype of the packaging vector could be further ensured without additional loss of expression by replacing the 3′ long terminal repeat with a mini-gene containing a heterologous transcriptional termination signal and a selection marker gene. Relevant to the design of transfer vector, deletion of the splice donor site itself had a dramatic negative effect of viral gene expression. KW - antiviral agents KW - disease vectors KW - gene expression KW - gene therapy KW - gene transfer KW - human diseases KW - phenotypes KW - RNA KW - vectors KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010711&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis. AU - Walker, P. S. AU - Scharton-Kersten, T. AU - Rowton, E. D. AU - Hengge, U. AU - Bouloc, A. AU - Udey, M. C. AU - Vogel, J. C. JO - Human Gene Therapy JF - Human Gene Therapy Y1 - 1998/// VL - 9 IS - 13 SP - 1899 EP - 1907 SN - 1043-0342 AD - Walker, P. S.: Dermatology Branch, NCI, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20000809301. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9008-11-1, 207137-56-2. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Cell-mediated immunity to Leishmania major was induced by injecting BALB/c mice intradermally with plasmid DNA expressing the conserved L. major cell surface glycoprotein gp63 (gp63-pcDNA-3). CD4 T lymphocytes from gp63-pcDNA-3-immunized mice proliferated and produced IFN (interferon)-γ (but not IL (interleukin)-4) when stimulated in vitro with freeze-thawed parasites, consistent with a Th1 immune response. In contrast, lymphocyte proliferation in animals immunized with freeze-thawed parasites was associated with IL-4 (but not IFN-γ) production, suggesting a nonprotective Th2 response. Challenge studies revealed that gp63-pcDNA-3 vaccination protected 30% of susceptible mice (21 of 70) from Leishmania infection, whereas neither gp63 protein (0 of 20) nor freeze-thawed parasite vaccines (0 of 50) were efficacious. Dendritic cells derived from skin of gp63-pcDNA-3-injected mice and used to immunize naive recipients also protected them from leishmaniasis. It is concluded that gp63-pcDNA-3 genetic vaccination results in a CD4-dependent Th1 immune response that correlates with protection from disease, and suggested that skin-derived dendritic cells are involved in priming this response. KW - antigen gp63 KW - CD4+ lymphocytes KW - cell mediated immunity KW - DNA vaccines KW - glycoproteins KW - human diseases KW - immune response KW - immunization KW - interferon KW - interleukin 4 KW - leishmaniasis KW - lymphocyte transformation KW - plasmid vectors KW - skin KW - surface antigens KW - surface proteins KW - T lymphocytes KW - vaccination KW - vaccine development KW - Leishmania major KW - mice KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - CD4+ cells KW - cellular immunity KW - dermis KW - gp63 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - leishmaniosis KW - membrane proteins KW - T cells KW - T4 lymphocytes KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) KW - Animal Models of Human Diseases (VV400) (New March 2000) KW - Animal Immunology (LL650) (New March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000809301&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - World Health Organization Classification of lymphomas: a work in progress. AU - Jaffe, E. S. AU - Harris, N. L. AU - Diebold, J. AU - Müller-Hermelink, H. K. A2 - Engert, A. A2 - Parsa-Parsi, R. A2 - Diehl, V. JO - Annals of Oncology JF - Annals of Oncology Y1 - 1998/// VL - 9 IS - Suppl. 5 SP - S25 EP - S30 SN - 0923-7534 AD - Jaffe, E. S.: Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992004157. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 31 ref. KW - classification KW - human diseases KW - lymphoma KW - neoplasms KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004157&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of molecular strategies to develop a live dengue vaccine. AU - Lai, C. J. AU - Bray, M. AU - Men, R. AU - Cahour, A. AU - Chen, W. AU - Kawano, H. AU - Tadano, M. AU - Hiramatsu, K. AU - Tokimatsu, I. AU - Pletnev, A. AU - Arakai, S. AU - Shameem, G. AU - Rinaudo, M. A2 - Zeytin, F. N. A2 - Gerlich, W. JO - Clinical and Diagnostic Virology JF - Clinical and Diagnostic Virology Y1 - 1998/// VL - 10 IS - 2/3 SP - 173 EP - 179 SN - 0928-0197 AD - Lai, C. J.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990502612. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 25 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology N2 - A study was conducted to use the successful construction of dengue type 4 virus (DEN4) cDNA, which yields infectious RNA transcripts, to provide a new approach to the development of safe and effective dengue vaccines. The 3′ and 5′ noncoding (NC) regions of the genome were targeted to construct DEN4 deletion mutants, because the sequences in these regions are thought to play an important role in the regulation of viral replication. DEN4 cDNA was also employed to construct a viable chimaeric virus with dengue type 1, 2 or 3 antigenicity, by substitution of heterotypic structural protein genes. Most viable mutants, recovered from the cDNA constructs, were partially restricted for growth in simian cells as analysed by plaque morphology assay and viral yield analysis. Several 3′ NC deletion mutants which exhibited a range of growth restriction in cell culture were further evaluated for infectivity and immunogenicity in rhesus monkeys. Occurrence and duration of viraemia were reduced for these deletion mutants, compared to the wild type DEN4. Analysis of antibody response to infection in rhesus monkeys also indicated that some of these mutants were attenuated. These DEN4 deletion mutants represent promising live dengue vaccine candidates that merit further clinical evaluation. Chimaera DEN1/DEN4 or DEN2/DEN4 which expresses DEN1 or DEN2 antigenicity were also used to infect monkeys. Most monkeys immunised with these chimaeric viruses, singly or in combination, developed high titres of neutralising antibodies and were protected against homotypic wild type DEN1 or DEN2 challenge. It was concluded that DEN4 and its derived chimaeric viruses of other 3 dengue serotype specificity, that contain appropriate attenuating mutations, have a potential use in a tetravalent live vaccine against dengue. KW - arboviruses KW - chimaeras KW - immune response KW - immunization KW - laboratory animals KW - mutants KW - RNA KW - vaccines KW - viral proteins KW - dengue 1 virus KW - dengue 2 virus KW - dengue 3 virus KW - dengue 4 virus KW - dengue virus KW - Macaca mulatta KW - monkeys KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - chimeras KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - ribonucleic acid KW - structural proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502612&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene therapy for infectious diseases. AU - Bunnell, B. A. AU - Morgan, R. A. JO - Clinical Microbiology Reviews JF - Clinical Microbiology Reviews Y1 - 1998/// VL - 11 IS - 1 SP - 42 EP - 56 SN - 0893-8512 AD - Bunnell, B. A.: Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1851, USA. N1 - Accession Number: 19982006318. Publication Type: Journal Article. Language: English. Number of References: 165 ref. Subject Subsets: Public Health N2 - A review of gene therapy is presented and anti-human immunodeficiency virus (HIV) gene therapy is discussed extensively. Areas considered are: nucleic acid-based genetic therapy (antisense DNA and RNA, ribozymes, and RNA decoys); protein-based approaches to gene therapy (transdominant negative proteins, anti-infectious cellular proteins, single-chain antibodies, and suicide genes); immunotherapy (DNA vaccines and agent-specific cytotoxic T cells); and target pathogens for antimicrobial gene therapy (HIV, human T cell lymphotropic virus, influenza virus, human papillomavirus, hepatitis B and C viruses, herpes simplex virus, Epstein-Barr virus, cytomegalovirus, Mycobacterium tuberculosis). Examples of clinical trials for infectious disease are presented, including marking of syngeneic T cells, transdominant negative Rev and gene vaccines. KW - gene therapy KW - human diseases KW - infectious diseases KW - reviews KW - vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - communicable diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006318&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Does Chlamydia pneumoniae cause coronary heart disease? AU - Quinn, T. C. JO - Current Opinion in Infectious Diseases JF - Current Opinion in Infectious Diseases Y1 - 1998/// VL - 11 IS - 3 SP - 301 EP - 307 SN - 0951-7375 AD - Quinn, T. C.: National Institute of Allergy and Infectious Diseases, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. N1 - Accession Number: 19992000316. Publication Type: Journal Article. Language: English. Number of References: 67 ref. KW - atherosclerosis KW - epidemiology KW - heart diseases KW - human diseases KW - pathogenesis KW - pathology KW - reviews KW - Chlamydophila pneumoniae KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Chlamydophila KW - Chlamydiaceae KW - Chlamydiales KW - Chlamydiae KW - Bacteria KW - prokaryotes KW - arteriosclerosis KW - bacterium KW - Chlamydia pneumoniae KW - coronary diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pain as a complication of HIV disease. AU - Hirschfeld, S. JO - AIDS Patient Care and STDs JF - AIDS Patient Care and STDs Y1 - 1998/// VL - 12 IS - 2 SP - 91 EP - 108 AD - Hirschfeld, S.: National Cancer Institute, Bldg 10, Rm 13N240, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004315. Publication Type: Journal Article. Language: English. Number of References: 208 ref. N2 - Pain as a symptom is common to many pathological conditions. At its most elementary level, it is a signal from peripheral nerves with specialized receptors that there is a change in the local environment, such as pressure, pH, temperature, or some other noxious stimulus, that can be detrimental to function. Pain is particularly prevalent in patients with HIV infection. The assessment, evaluation, and treatment of pain should be an integral part of comprehending patient care. Therapy for pain should be directed toward treating the underlying cause. Analgesia should be multimodal. As pharmacology research provides agents with greater specificity and presumably fewer side effects, the functional status of patients is expected to benefit. The treatment of pain is a tacit contract with the patient that the diminution of quality of life will be addressed. It is critical for health care providers to anticipate and recognize the symptoms and effects of pain and to request specialized consultation for refractory problems. A number of hospitals and foundations have begun continuing education programmes to provide instruction and outreach to health care providers who are charged with the care of those with HIV infection. The effects of satisfactory treatment can be profound. There are anecdotal reports of patients whose entire affect, appetite and quality of life changed once it was recognized that pain was an inhibitor of function. KW - acquired immune deficiency syndrome KW - adverse effects KW - health care KW - HIV infections KW - hospitals KW - human diseases KW - human immunodeficiency viruses KW - infection KW - pain KW - patient care KW - patients KW - peripheral nerves KW - pharmacology KW - symptoms KW - temperature KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - nerves KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004315&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - CCR-5 genotype and sexual transmission of HIV-1. AU - O'Brien, T. R. AU - Padian, N. S. AU - Hodge, T. AU - Goedert, J. J. AU - O'Brien, S. J. AU - Carrington, M. T2 - AIDS JO - AIDS JF - AIDS Y1 - 1998/// VL - 12 IS - 4 SP - 444 EP - 445 SN - 0269-9370 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA. N1 - Accession Number: 19982004359. Publication Type: Correspondence. Language: English. Number of References: 6 ref. N2 - In this study, with a total of 283 female sex partners of HIV-1-infected men, no evidence was found to suggest that the risk of acquiring HIV-1 through heterosexual intercourse was decreased in women who are heterozygous for CCR-5 Δ32. KW - alleles KW - chemokines KW - cytokines KW - heterosexual transmission KW - HIV-1 infections KW - human diseases KW - infectivity KW - receptors KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Abdominal presentation of Burkitt's lymphoma in an HIV-positive patient. AU - Saif, M. W. AU - Greenberg, B. R. JO - AIDS Patient Care and STDs JF - AIDS Patient Care and STDs Y1 - 1998/// VL - 12 IS - 7 SP - 567 EP - 571 AD - Saif, M. W.: National Cancer Institute, 4700 Bradley Blvd., Chevy Chase, MD 20815, USA. N1 - Accession Number: 19982011076. Publication Type: Journal Article. Language: English. Number of References: 14 ref. N2 - A case is described of a patient with HIV infection who presented with abdominal pain and distension and was found to have an intraabdominal type of Burkitt's lymphoma. KW - abdomen KW - acquired immune deficiency syndrome KW - Burkitt's lymphoma KW - case reports KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphoma KW - neoplasms KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - cancers KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011076&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pilot study of the immunologic effects of recombinant human growth hormone and recombinant insulin-like growth factor in HIV-infected patients. AU - Nguyen, B. Y. AU - Clerici, M. AU - Venzon, D. J. AU - Bauza, S. AU - Murphy, W. J. AU - Longo, D. L. AU - Baseler, M. AU - Gesundheit, N. AU - Broder, S. AU - Shearer, G. AU - Yarchoan, R. JO - AIDS JF - AIDS Y1 - 1998/// VL - 12 IS - 8 SP - 895 EP - 904 SN - 0269-9370 AD - Nguyen, B. Y.: HIV and AIDS Malignancy Branch, Bldg 10, Rm 12N226, National Institutes of Health, Bethesda MD 20892-1906, USA. N1 - Accession Number: 19982008033. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 61912-98-9, 9002-72-6. N2 - In a randomized but not blinded trial 24 HIV-infected patients with CD4+ cell counts of 100×400×106/l who were receiving nucleoside antiretroviral therapy were given recombinant human growth hormone (rhGH), recombinant human insulin-like growth factor type 1 (rhlGF-1), or the combination administered subcutaneously for 12 weeks. Plasma IGF-1 levels were low or low-normal prior to treatment and increased with all 3 therapies. There were no significant changes in CD4+ cell counts, RA/RO CD4+ cell subsets, natural killer cell function, immunoglobin levels, or in vitro interleukin-2 production in response to mitogen or alloantigens. However, there was an upward trend (and for p18IIIB a statistically significant increase) in the in vitro IL-2 production in response to each of 5 HIV envelope peptides. Potential toxic effects included fatigue, arthralgia, oedema, myalgia, and headache. Patients also were noted to have weight gain averaging 4 kg early in the course of treatment. These results suggest that treatment with rhGH/rhIGF-1 was reasonably well tolerated and that modest improvement in HIV-specific immune function was attained. KW - adverse effects KW - antiviral agents KW - blood plasma KW - CD4+ lymphocytes KW - growth factors KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunotherapy KW - insulin-like growth factor KW - interleukins KW - leukocyte count KW - mitogens KW - peptides KW - somatotropin KW - T lymphocytes KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - CD4+ cells KW - cell count KW - growth hormone KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - plasma (blood) KW - somatomedin C KW - T cells KW - T4 lymphocytes KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008033&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An update on drug interactions with zidovudine. AU - Piscitelli, S. C. AU - Polis, M. A. JO - AIDS Patient Care and STDs JF - AIDS Patient Care and STDs Y1 - 1998/// VL - 12 IS - 9 SP - 687 EP - 690 AD - Piscitelli, S. C.: Laboratory of Immunoregulation, National Institutes of Health, Bldg 10, Rm. 11C103, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014258. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 30516-87-1. KW - adverse effects KW - antiviral agents KW - drug antagonism KW - drug combinations KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - AZT KW - chemotherapy KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014258&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques. AU - Heyes, M. P. AU - Saito, K. AU - Lackner, A. AU - Wiley, C. A. AU - Achim, C. L. AU - Markey, S. P. JO - FASEB Journal JF - FASEB Journal Y1 - 1998/// VL - 12 IS - 10 SP - 881 EP - 896 SN - 0892-6638 AD - Heyes, M. P.: Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982012882. Publication Type: Journal Article. Language: English. Number of References: 72 ref. N2 - The results of this study demonstrate a role for induction of indoleamine-2,3-dioxygenase in accelerating the local formation of quinolinic acid within the brain tissue, particularly in areas of encephalitis, rather than entry of quinolinic acid into the brain from the meninges or blood. Strategies to reduce quinolinic acid production, targeted at intracerebral sites, are potential approaches to therapy. KW - brain KW - cerebrospinal fluid KW - cytokines KW - encephalitis KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - metabolites KW - nervous system diseases KW - neurotoxicity KW - neurotoxins KW - pathogenesis KW - Macaca KW - Macaca mulatta KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Macaca KW - Homo KW - Hominidae KW - cerebrum KW - encephalomyelitis KW - human immunodeficiency virus KW - neuropathy KW - quinolinic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012882&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Individual prognoses of long-term responses to antiretroviral treatment based on virological, immunological and pharmacological parameters measured during the first week under therapy. AU - Mueller, B. U. AU - Zeichner, S. L. AU - Kuznetsov, V. A. AU - Heath-Chiozzi, M. AU - Pizzo, P. A. AU - Dimitrov, D. S. JO - AIDS JF - AIDS Y1 - 1998/// VL - 12 IS - 15 SP - F191 EP - F196 SN - 0269-9370 AD - Mueller, B. U.: Laboratory of Experimental and Computational Biology, Division of Basic Sciences, National Cancer Institute-FCRDC, Building 469, Room 216, Miller Drive, PO Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982014343. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 63231-63-0, 155213-67-5. N2 - Forty one HIV-1-infected children were treated with ritonavir for 12 weeks followed by triple drug combination treatment, and the kinetics of virus decay in plasma, ritonavir concentration and CD4+ cell counts were measured. A robust multivariate pattern recognition method was used for prediction of the long-term virological responses. The virus decay rate constants calculated from measurements of plasma viral RNA concentrations on the first, second, third, fourth and seventh day on therapy, the drug concentrations in the plasma on day 7, and the pretreatment levels of viral RNA and CD4+ cell counts, correlated with long-term levels of plasma HIV-1 RNA. The combination of these parameters contained sufficient information for correct and robust prediction of the long-term response in 88% of the treated children. The predictions of individual responses were stable as demonstrated by a cross-validation analysis, which was highly statistically significant (r = 0.87) and specific. KW - antiviral agents KW - CD4+ lymphocytes KW - children KW - combination therapy KW - disease course KW - drug therapy KW - human diseases KW - immune response KW - leukocyte count KW - prognosis KW - prognostic markers KW - proteinase inhibitors KW - ritonavir KW - RNA KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4+ cells KW - cell count KW - chemotherapy KW - combined modality therapy KW - disease progression KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - multimodal treatment KW - protease inhibitors KW - ribonucleic acid KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014343&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protease inhibitor and triple-drug therapy: cellular immune parameters are not restored in pediatric AIDS patients after 6 months of treatment. AU - Chougnet, C. AU - Fowke, K. R. AU - Mueller, B. U. AU - Smith, S. AU - Zuckerman, J. AU - Jankelevitch, S. AU - Steinberg, S. M. AU - Luban, N. AU - Pizzo, P. A. AU - Shearer, G. M. JO - AIDS JF - AIDS Y1 - 1998/// VL - 12 IS - 18 SP - 2397 EP - 2406 SN - 0269-9370 AD - Chougnet, C.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992002440. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 130068-27-8, 308079-78-9, 150378-17-9, 155213-67-5. Subject Subsets: Public Health N2 - To assess whether treatment of HIV-positive children with antiretroviral drugs for a 6-month period would improve immune function significantly, an immunological assessment of 89 HIV-positive children who received protease inhibitor (indinavir or ritonavir) monotherapy for 12-16 weeks as part of phase I/II studies, followed by triple antiretroviral therapy for an additional 12 weeks, was conducted in the USA [date not given]. Immunological parameters were assessed in vitro at 4 time points (at enrolment, at weeks 2-4, at weeks 12-16, and at weeks 24-28). Assessments included: cytokine production by monocytes, T-cell proliferation to mitogen or recall antigens (including an HIV antigen), and apoptotic cell death. Plasma levels of tumour necrosis factor (TNF)-α and soluble TNF receptor (sTNF-R) were also measured, in addition to CD4+ T-lymphocyte counts and viral load. In addition, limited analyses were performed on samples from 17 children after 120 weeks of therapy, including 104 weeks of triple therapy. At enrolment, the 89 children exhibited severe immune defects. Antiretroviral therapy raised CD4+ T-lymphocyte counts significantly and decreased viral loads. In contrast, the in vitro immune parameters studied were not improved, except for plasma levels of sTNF-RII which decreased in parallel with the decrease in viral load. In addition, there was a trend towards increased skin test reactivity for the ritonavir-treated children. No differences were seen in the immune parameters whether the patients were treated with mono- or triple therapy. Results obtained after 120 weeks of therapy demonstrated that defective interleukin-12 production was not restored by long-term therapy. KW - apoptosis KW - CD4+ lymphocytes KW - cell mediated immunity KW - children KW - cytokines KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - indinavir KW - interleukin 10 KW - interleukin 12 KW - interleukins KW - proteinase inhibitors KW - ritonavir KW - tumour necrosis factor KW - viral diseases KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cachectin KW - cachexin KW - CD4+ cells KW - cellular immunity KW - chemotherapy KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - protease inhibitors KW - T4 lymphocytes KW - tumor necrosis factor KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002440&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of guidelines for initiation of highly active antiretroviral therapy in a longitudinal cohort of HIV-infected individuals. AU - Ioannidis, J. P. A. AU - O'Brien, T. R. AU - Goedert, J. J. JO - AIDS JF - AIDS Y1 - 1998/// VL - 12 IS - 18 SP - 2417 EP - 2423 SN - 0269-9370 AD - Ioannidis, J. P. A.: HIV Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992002441. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health N2 - To evaluate several expert-developed guidelines for initiating highly active antiretroviral therapy (HAART) in patients with HIV infection, the application of such guidelines was simulated in a cohort of HIV-infected patients established and followed before HAART was available; the patients' survival without disease progression was evaluated in the absence of HAART. Longitudinal data were used that had been collected from 1982 to 1995 on a prospective cohort of 133 homosexual men from New York and District of Columbia (USA) with known or closely approximated dates of HIV-1 seroconversion and negligible antiretroviral exposure. The main definition of disease progression was CD4 cell count ≤300 × 106/litre or development of clinical AIDS diagnosis within 12 months. The mean number of years between the recommended initiation of therapy and when disease progression occurred in the absence of HAART were as follows: initiation of treatment at first visit, 4.81 years; CD4 cell count <500 × 106/litre or serum RNA >5000 copies/ml (at least 10 000 copies/ml fresh plasma), 4.35 years; CD4+ cells <500 × 106/litre or serum RNA >20 000 copies/ml (at least 40 000 copies/ml fresh plasma), 3.61 years; and CD4+ cells <500 × 106/litre, 2.72 years. The percentage of patients who had disease progression before HAART would have been recommended was 0.8, 1.6, 3.2 and 13.6% with each of these 4 approaches, respectively. It is concluded that implementation of recommended treatment guidelines will result in a substantial proportion of patients being treated for long periods before immunological or clinical disease progression would have occurred in the absence of HAART. KW - antiviral agents KW - disease course KW - disease models KW - drug therapy KW - guidelines KW - human diseases KW - human immunodeficiency viruses KW - viral diseases KW - District of Columbia KW - New York KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - chemotherapy KW - disease progression KW - human immunodeficiency virus KW - recommendations KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002441&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Life without white fat: a transgenic mouse. AU - Moitra, J. AU - Mason, M. M. AU - Olive, M. AU - Krylov, D. AU - Gavrilova, O. AU - Marcus-Samuels, B. AU - Feigenbaum, L. AU - Lee, E. AU - Aoyama, T. AU - Eckhaus, M. AU - Reitman, M. L. AU - Vinson, C. JO - Genes & Development JF - Genes & Development Y1 - 1998/// VL - 12 IS - 20 SP - 3168 EP - 3181 SN - 0890-9369 AD - Moitra, J.: Laboratory of Biochemistry, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892 USA. N1 - Accession Number: 19981417962. Publication Type: Journal Article. Language: English. Number of References: 2 pp. of ref. Registry Number: 50-99-7, 9004-10-8, 169494-85-3. Subject Subsets: Human Nutrition; Agricultural Biotechnology N2 - A transgenic mouse with no white fat tissue throughout life is described. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2 enhancer/promoter. This protein prevents the DNA binding of B-ZIP transcription factors of both the C/EBP and Jun families. The transgenic mice (named A-ZIP/F-1) have no white adipose tissue and dramatically reduced amounts of brown adipose tissue, which is inactive. They are initially growth delayed, but by week 12, surpass their littermates in weight. The mice eat, drink, and urinate copiously, have decreased fecundity, premature death, and frequently die after anesthesia. The physiological consequences of having no white fat tissue are profound. The liver is engorged with lipid, and the internal organs are enlarged. The mice are diabetic, with reduced leptin (20-fold) and elevated serum glucose (3-fold), insulin (50- to 400-fold), free fatty acids (2-fold), and triglycerides (3- to 5-fold). The A-ZIP/F-1 phenotype suggests a mouse model for the human disease lipoatrophic diabetes (Seip-Berardinelli syndrome), indicating that the lack of fat can cause diabetes. The myriad of consequences of having no fat throughout development can be addressed with this model. KW - adipocytes KW - biotechnology KW - blood sugar KW - body fat KW - diabetes KW - fatty acids KW - genetically engineered organisms KW - glucose KW - insulin KW - leptin KW - phenotypes KW - transgenic animals KW - triacylglycerols KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood glucose KW - dextrose KW - fat cells KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - glucose in blood KW - GMOs KW - transgenic organisms KW - triglycerides KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells. AU - Al-Harthi, L. AU - Owais, M. AU - Arya, S. K. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1998/// VL - 14 IS - 1 SP - 59 EP - 64 SN - 0889-2229 AD - Al-Harthi, L.: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003039. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - HIV-2 inhibited both the production of extracellular HIV-1 p24 antigen and intracellular viral RNA, suggesting the involvement of transcriptional downmodulation. Some of the defective HIV-2 proviruses also inhibited HIV-1. In some cases, these defects were transcomplemented by the corresponding HIV-1 gene products, emphasizing cross-regulation between the two viruses. The phenotype of one of the mutant HIV-1 proviruses suggested that posttranscriptional effects may also occur. In addition to the possible HIV-2 suppression of HIV-1 in vivo by cross-protective immune mechanisms, intracellular inhibition, noted here, may be another line of defence. KW - antigens KW - core protein p24 KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - interactions KW - phenotypes KW - proviruses KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - antigenicity KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - human immunodeficiency virus type 2 KW - immunogens KW - p24 KW - p24 antigen KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003039&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of 3D QSAR methodology for data mining the National Cancer Institute Repository of Small Molecules: application to HIV-1 reverse transcriptase inhibition. AU - Gussio, R. AU - Pattabiraman, N. AU - Kellogg, G. E. AU - Zaharevitz, D. W. JO - Methods, A Companion to Methods in Enzymology JF - Methods, A Companion to Methods in Enzymology Y1 - 1998/// VL - 14 IS - 3 SP - 255 EP - 263 AD - Gussio, R.: Target Structure-Based Drug Discovery Group, Information Technology Branch, Developmental Therapeutics Program, National Cancer Institute, 811 Executive Plaza North, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19982008466. Publication Type: Journal Article. Language: English. Number of References: 29 ref. KW - antiviral agents KW - databases KW - enzyme inhibitors KW - human diseases KW - inhibition KW - methodology KW - reverse transcriptase inhibitors KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - data banks KW - human immunodeficiency virus type 1 KW - methods KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008466&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lessons from the cat: feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1. AU - Elder, J. H. AU - Dean, G. A. AU - Hoover, E. A. AU - Hoxie, J. A. AU - Malim, M. H. AU - Mathes, L. AU - Neil, J. C. AU - North, T. W. AU - Sparger, E. AU - Tompkins, M. B. AU - Tompkins, W. A. F. AU - Yamamoto, J. AU - Yuhki, N. AU - Pedersen, N. C. AU - Miller, R. H. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1998/// VL - 14 IS - 9 SP - 797 EP - 801 SN - 0889-2229 AD - Elder, J. H.: Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982010447. Publication Type: Journal Article. Language: English. N2 - In July 1997 the Division of AIDS of the National Institute of Allergy and Infectious Diseases in the USA sponsored a workshop entitled "Use of the FIV/cat model for development of anti-HIV vaccines and therapeutics." The purpose of this workshop was to provide a forum for presenting new data arising from FIV research, assess the utility of the FIV/cat model, identify areas applicable to HIV/AIDS research, and solicit input from investigators on scientific gaps that can benefit from additional support. The meeting brought to the fore numerous areas where the FIV/cat model can serve as a valuable tool for developing new therapeutic strategies and vaccine designs applicable to the treatment and prevention of HIV-1 infection. KW - animal models KW - human immunodeficiency viruses KW - pathogenesis KW - research KW - therapy KW - vaccines KW - cats KW - feline immunodeficiency virus KW - Retroviridae KW - Felis KW - Felidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - studies KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The search for novel malaria transmission-blocking targets in the mosquito midgut. AU - Shahabuddin, M. AU - Cociancich, S. AU - Zieler, H. JO - Parasitology Today JF - Parasitology Today Y1 - 1998/// VL - 14 IS - 12 SP - 493 EP - 497 AD - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990800523. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Recent studies to identify the cellular and biochemical factors that affect the malaria parasite's development in the mosquito are summarized, with particular reference to factors influencing the early development of Plasmodium, receptor-mediated interactions between the parasite and the mosquito midgut, and the gut-associated immune responses directed against Plasmodium. KW - biological development KW - disease vectors KW - host parasite relationships KW - interactions KW - midgut KW - parasites KW - reviews KW - transmission blocking immunity KW - Anopheles KW - Culicidae KW - Diptera KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - parasite host relationships KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990800523&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine profiles in HIV type 1 disease and protection. AU - Shearer, G. M. AU - Clerici, M. JO - AIDS Research and Human Retroviruses JF - AIDS Research and Human Retroviruses Y1 - 1998/// VL - 14 IS - sup.2 SP - S149 EP - S152 SN - 0889-2229 AD - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982010984. Publication Type: Journal Article. Language: English. Number of References: 41 ref. KW - cytokines KW - human diseases KW - immune response KW - immunity KW - immunopathology KW - immunotherapy KW - interleukins KW - reviews KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010984&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evolution of a common structural core in the internal ribosome entry sites of Picornavirus. AU - Le ShuYun AU - Maizel, J. V., Jr. JO - Virus Genes JF - Virus Genes Y1 - 1998/// VL - 16 IS - 1 SP - 25 EP - 38 SN - 0920-8569 AD - Le ShuYun: Laboratory of Mathematical Biology, Division of Cancer Biology Diagnosis and Centers, National Cancer Institute, NIH, Bldg 469, Room 151, Frederick, Maryland 21702. N1 - Accession Number: 19982206885. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science N2 - The translational control involving internal ribosome binding occurs in poliovirus (PV), human rhinoviruses (HRV), encephalomyocarditis virus (EMCV), foot-and-mouth disease virus (FMDV), and hepatitis A virus (HAV). Internal ribosome binding utilizes cis-acting genetic elements of approximately 450 nucleotides (nt) termed the internal ribosome entry sites (IRES) found in these picornaviral 5′-untranslated region (5′UTR). Although these IRES elements are quite different in their primary sequence, a similar folding structure with a conserved 3′ structural core exists in the IRES. Phylogenetic analysis and RNA folding of the 5′ UTR of picornaviruses, including PV types 1-3, coxsackievirus types A and B, swine vesicular disease virus, echoviruses, enteroviruses (human and bovine), HRV, HAV, EMCV, mengovirus, Theiler's murine encephalomyelitis viruses, FMDV, and equine rhinoviruses, indicates that the predicted conserved structural core is indeed a general structural feature for all members of the picornavirus family. The evolution of a common structural core likely occurred by the gradual addition or deletion of structural domains and elements to preserve a similar tertiary structure that facilitates the utilization of the IRES in specific host-cell environments. KW - evolution KW - phylogeny KW - Aphthovirus KW - Cardiovirus KW - Coxsackieviruses KW - encephalomyocarditis virus KW - Foot-and-mouth disease virus KW - human echoviruses KW - Picornaviridae KW - Poliovirus KW - Theilovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Enterovirus KW - Cardiovirus KW - Foot-and-mouth disease virus KW - human echovirus KW - murine encephalomyelitis virus KW - polioviruses KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982206885&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer Institute. AU - Granovsky, M. O. AU - Mueller, B. U. AU - Nicholson, H. S. AU - Rosenberg, P. S. AU - Rabkin, C. S. JO - Journal of Clinical Oncology JF - Journal of Clinical Oncology Y1 - 1998/// VL - 16 IS - 5 SP - 1729 EP - 1735 SN - 0732-183X AD - Granovsky, M. O.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6130 Executive Blvd., EPN/434, Rockville, MD 20852, USA. N1 - Accession Number: 19982009761. Publication Type: Journal Article. Language: English. Number of References: 37 ref. N2 - The Children's Cancer Group (CCG) and the National Cancer Institute (NCI) of the USA were retrospectively surveyed for cases of cancer that occurred between July 1982 and February 1997 in children who were HIV seropositive before or at the time of cancer diagnosis. 64 children (39 boys, 25 girls) with 65 tumours were reported. 37 children (58%) acquired HIV infection vertically (median age at cancer diagnosis, 4.3 years); 22 children (34%) acquired HIV through transfusion of blood or blood products (median age at cancer diagnosis, 13.4 years). 42 children (65%) had non-Hodgkin's lymphoma (NHL). 11 children (17%) had leiomyosarcomas (or leiomyomas), which are otherwise exceptionally rare in children. Other malignancies included acute leukaemia (5 children), Kaposi's sarcoma (3 children), Hodgkin's disease (2 children), vaginal carcinoma in situ (1 child). Median survival after NHL diagnosis was 6 months (range, 1 day to 89 months) and after leiomyosarcoma, 12 months (range, 10 days to 19 months). The average monthly after NHL diagnosis was 12% n the first 6 months, which decreased to about 2% thereafter. In contrast, the monthly death rate after leiomyosarcoma diagnosis increased from 5% in the first 6 months to about 20% thereafter. KW - acquired immune deficiency syndrome KW - children KW - diagnosis KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - leukaemia KW - lymphoma KW - mortality KW - neoplasms KW - sarcoma KW - survival KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - blood cancer KW - cancers KW - death rate KW - human immunodeficiency virus KW - leucaemia KW - leukemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009761&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Advances in HIV/AIDS statistical methodology over the past decade. AU - Foulkes, M. A. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1998/// VL - 17 IS - 1 SP - 1 EP - 25 SN - 0277-6715 AD - Foulkes, M. A.: Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Correspondence address; SmithKline Beecham Biologicals, rue de l'Institut, 89, B-1330 Rixensart, Belgium. N1 - Accession Number: 19982006997. Publication Type: Journal Article. Language: English. Number of References: 358 ref. N2 - This review provides a synopsis of the developments over the past decade in mathematical and statistical methodology in response to the AIDS epidemic. It includes highlights of the development of epidemic models, approaches to describing the natural history of HIV infection, and the methods developed for HIV therapeutic or prevention research. An extensive bibliography is included. The intention is to provide a historical perspective on the methodological developments and a framework for identifying HIV/AIDS-related needs for the future. KW - acquired immune deficiency syndrome KW - human diseases KW - human immunodeficiency viruses KW - mathematical models KW - methodology KW - research KW - statistics KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - methods KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006997&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV Tat protein requirements for transactivation and repression of transcription are separable. AU - Brown, J. A. AU - Howcroft, T. K. AU - Singer, D. S. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1998/// VL - 17 IS - 1 SP - 9 EP - 16 AD - Brown, J. A.: Moleular Regulation Section, Experimental Immunology Branch, National Cancer Institute, Bldg 10, Rm 4B-17, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003004. Publication Type: Journal Article. Language: English. Number of References: 39 ref. N2 - The HIV Tat protein, primarily characterized as a transcriptional activator of the viral long terminal repeat (LTR), is also a potent repressor of major histocompatibility complex (MHC) class I transcription. This study demonstrates that these two functional activities are distinct and mediated by discrete, but overlapping, structural domains of Tat. Tat repressor activity depends on C-terminal sequences, whereas transactivation depends on N-terminal sequences; both functions require core sequences. The repressor activity requires a domain encompassing the region encoded by the second exon of the Tat gene, beginning at amino acid 73, with a C-terminal limit between amino acids 80 and 83. Tat repressor function also depends on the presence of a lysine at position 41, located within the core of the protein. Tat repressor activity is independent of two N-terminal domains essential for transactivation: the acidic segment and the cysteine-rich region. Conversely, Tat transactivation is independent of the second exon-encoded region of Tat. As further support for this novel model of separable Tat functions, it is shown that in murine fibroblasts, Tat represses class I promoter activity, but does not transactivate the HIV LTR. It is proposed that distinct structural domains mediate the two functionally distinct activities associated with the Tat protein. KW - amino acids KW - human diseases KW - human immunodeficiency viruses KW - major histocompatibility complex KW - promoters KW - proteins KW - Tat protein KW - transactivation KW - transcription KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA transcription KW - histocompatibility complex KW - human immunodeficiency virus KW - promoter region KW - promoter sequences KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003004&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estimating the cumulative incidence of HIV infection among persons with haemophilia in the United States of America. AU - Rosenberg, P. S. AU - Goedert, J. J. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1998/// VL - 17 IS - 2 SP - 155 EP - 168 SN - 0277-6715 AD - Rosenberg, P. S.: National Cancer Institute, 6130 Executive Blvd, EPN/403, Rockville, MD 20852, USA. N1 - Accession Number: 19982004031. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - Complementary approaches were used to estimate the cumulative incidence of infection with HIV among persons with haemophilia in the USA. One approach, ratio estimation, divided the cumulative number of haemophiliacs diagnosed with AIDS in the USA by the corresponding cumulative proportion with AIDS among HIV-positive subjects in the Multicenter Hemophilia Cohort Study (MHCS). The other approach, back-calculation, reconstructed past HIV incidence from national surveillance of AIDS using essentially non-parametric estimates of the hazard functions for AIDS and for pre-AIDS death. Confidence intervals were derived that fully incorporated uncertainty about the hazard functions. Results from the 2 approaches were consistent. Around 9200 haemophiliacs became infected during the course of the epidemic. Of them, around 7000 were living with HIV or AIDS as of 31 December 1992 and at least 5630 as of 31 December 1995. Credible calculations for this group must account for those who die before AIDS and for the significantly longer incubation times in those infected as children or adolescents. The consistency of back-calculation and cohort data in haemophiliacs supports the use of back-calculation to estimate prevalence in other populations. KW - acquired immune deficiency syndrome KW - children KW - epidemiology KW - haemophilia KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - incidence KW - infection KW - statistical analysis KW - America KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - hemophilia KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - statistical methods KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004031&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phylogenetic evidence for the improved RNA higher-order structure in internal ribosome entry sequences of HCV and pestiviruses. AU - Le ShuYun AU - Liu WeiMin AU - Maizel, J. V., Jr. JO - Virus Genes JF - Virus Genes Y1 - 1998/// VL - 17 IS - 3 SP - 279 EP - 295 SN - 0920-8569 AD - Le ShuYun: Laboratory of Experimental and Computational Biology Division of Basic Sciences National Cancer Institute, N1H, Bldg 469, Room 151, Frederick, MD 21702, USA. N1 - Accession Number: 19992201678. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 63231-63-0. Subject Subsets: Veterinary Science; Veterinary Science N2 - The genetic relationship of the 5′ untranslated region (UTR) and internal ribosome entry sequence (IRES) between hepatitis C virus (HCV) and animal pestiviruses was analysed. Phylogenetic analysis and RNA folding indicate a common RNA structure of the UTR of HCV and the animal pestiviruses, including HCV types 1-11, bovine diarrhea virus, border disease virus and swine fever virus. Although the common RNA structure shares similar features to that proposed for the IRES of picornavirus, phylogenetic evidence suggests 4 new tertiary interactions between conserved terminal hairpin loops and between the terminal hairpin loop of F2b and the short coding sequence for HCV and pestiviruses. It is suggested that the higher-order structures of IRES cis-acting elements for HCV and animal pestivirus are composed of stem-loop structures B-C, domains E-H, stem-loop structure J and 4 additional tertiary interactions. The common structure of IRES elements for these viruses forms a compact structure by these tertiary interactions and stem stacking. The active structural core is centred in the junction domain of E-H that is also conserved in all members of picornaviruses. The model suggests that the requirement for a small segment of the 5′ coding sequence is to form the distinct tertiary structure that facilitates the cis-acting function of the HCV IRES in the internal initiation of the translational control. KW - phylogenetics KW - RNA KW - structure KW - translation KW - viral diseases KW - hepatitis C virus KW - Pestivirus KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Pestivirus KW - Bovine diarrhea virus KW - Bovine diarrhoea virus KW - internal ribosome entry sequence KW - ribonucleic acid KW - RNA translation KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992201678&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The immunogenicity of Haemophilus influenzae type b conjugate vaccines in children born to human immunodeficiency virus-infected women. AU - Read, J. S. AU - Frasch, C. E. AU - Rich, K. AU - Fitzgerald, G. A. AU - Clemens, J. D. AU - Pitt, J. AU - Pelton, S. I. AU - Hanson, I. C. AU - Handelsman, E. AU - Diaz, C. AU - Fowler, M. G. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1998/// VL - 17 IS - 5 SP - 391 EP - 397 SN - 0891-3668 AD - Read, J. S.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA. N1 - Accession Number: 19982012206. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health N2 - Among 227 children (35 HIV-infected, 192 uninfected) at the 9-month study visit who were known to have received age-appropriate immunization with CRM197 mutant Corynebacterium diphtheriae protein-conjugated Hib vaccine, geometric mean antibody concentrations were lower among HIV-infected children (1.64 µg/ml) than among uninfected children (2.70 µg/ml), although the difference was not statistically significant. Anti-polyribosylribitol (PRP) antibody concentrations did not vary significantly among these HIV-infected children with predominantly mild-moderate disease progression according to clinical category, immunological stage or viral load (P≥0.48). The proportion of children with antibody concentrations ≥1.0 µg/ml did not vary significantly according to HIV infection status (73% uninfected, 74% infected) or, if infected, clinical or immunological disease progression or viral load. Similar results were obtained among 127 children (17 HIV-infected, 110 uninfected) eligible for analysis at the 24-month study visit. Changes in antibody concentrations over time (between 9 and 24 months of age) did not differ significantly among 10 HIV-infected as compared with 72 uninfected children (P=0.81). These results suggest that HIV-infected children with predominantly mild-moderate disease progression respond reasonably well in terms of a quantitative antibody response to Hib conjugate vaccines during the first 2 years of life. Research to further characterize the immune response to Hib conjugate vaccines and to further delineate the "durability" of anti-PRP antibody concentrations beyond 2 years of life should be pursued. KW - antibodies KW - children KW - conjugate vaccines KW - disease course KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunization KW - infants KW - transmission KW - vaccines KW - viral load KW - women KW - Corynebacterium KW - Haemophilus KW - Haemophilus influenzae KW - Haemophilus influenzae type b KW - Human immunodeficiency virus 1 KW - man KW - Corynebacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Proteobacteria KW - Haemophilus KW - Haemophilus influenzae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogenicity KW - immunological reactions KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012206&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relationship between unsupplemented vitamin A serum concentrations and measles vaccine response in Jamaican children. AU - Willy, M. E. AU - Hoover, D. R. AU - Halsey, N. A. AU - Maloney, E. M. AU - Pate, E. J. AU - Wiktor, S. Z. AU - Blattner, W. A. AU - Manns, A. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1998/// VL - 17 IS - 6 SP - 526 EP - 528 SN - 0891-3668 AD - Willy, M. E.: Hospital Epidemiology Service, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982013321. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition; Tropical Diseases N2 - A total of 208 children, recruited from a larger prospective study of human T cell lymphotrophic virus type I (HTLV-I) infection among Jamaican mothers and infants, were included in the analysis [date not given]. 21 were HTLV-I seropositive. 127 (61%) of the 208 children had vitamin A serum concentrations <1.05 µmol/litre and 43 (21%) had sub-clinical vitamin A deficiency (serum concentration <0.70 µmol/litre). Mean vitamin A serum concentrations were similar for male and female children (0.92 and 0.97 µmol/litre, respectively). Median age of measles vaccination was 9.6 months of age. 11 of 208 children (5%) were seronegative after vaccination. There was no association between an altered measles vaccination response and HTLV-I seropositivity. The relative risk for being measles antibody-seronegative after measles vaccination for children with vitamin A serum concentrations ≤1.05 vs. >1.05 µmol/litre was 1.1 (95% confidence interval, 0.3-3.7). Vitamin A serum concentration and postvaccination values obtained from an ELISA specific for measles IgG were not correlated. It is concluded that vitamin A serum concentrations do not affect the immune response to measles vaccination when children are vaccinated at 9 months and are not receiving vitamin A supplementation. KW - children KW - human diseases KW - immune response KW - immunization KW - infants KW - retinol KW - vaccination KW - vaccines KW - Jamaica KW - man KW - measles virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Morbillivirus KW - Paramyxovirinae KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - axerophthol KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013321&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for bloodstream infections at a cancer center. AU - Velasco, E. AU - Thuler, L. C. S. AU - Martins, C. A. S. AU - Dias, L. M. C. AU - Gonçalves, V. M. S. JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1998/// VL - 17 IS - 8 SP - 587 EP - 590 SN - 0934-9723 AD - Velasco, E.: Infectious Disease Service and Hospital Infection Control, National Cancer Institute, Cancer Hospital, Rio de Janeiro, Praça Cruz Vermelha, 23 Centro, Cep: 20 130-130, Brazil. N1 - Accession Number: 19992001603. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Tropical Diseases N2 - A hospital-based matched case-control study was conducted an the National Cancer Centre, Rio de Janeiro, Brazil, in order to identify risk factors for the development of bloodstream infections in adult hospitalized patients. Between January 1993 and December 1994, 264 episodes of bloodstream infection were evaluated. Significant variables identified by univariate analysis were included in a multivariate model that showed that central venous catheter (odds ratio (OR), 6.71), poor performance status (OR, 3.40), weight loss (OR, 2.47), haematological diseases (OR, 2.24), and previous antimicrobial therapy (OR, 2.12) independently influenced the outcome. The knowledge of modifiable risk factors is useful in the development of strategies that may contribute to the prevention of bloodstream infections. KW - aplastic anaemia KW - bacteraemia KW - catheters KW - immunocompromised hosts KW - leukaemia KW - lymphoma KW - myeloma KW - neoplasms KW - nosocomial infections KW - risk factors KW - weight losses KW - Brazil KW - Rio de Janeiro KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Brazil KW - aplastic anemia KW - bacteremia KW - blood cancer KW - cancers KW - hospital infections KW - leucaemia KW - leukemia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001603&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. AU - Mofenson, L. M. AU - Yogev, R. AU - Korelitz, J. AU - Bethel, J. AU - Krasinski, K. AU - Moye, J., Jr. AU - Nugent, R. AU - Rigau-Perez, J. G. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1998/// VL - 17 IS - 10 SP - 872 EP - 880 SN - 0891-3668 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 19992000959. Publication Type: Journal Article. Corporate Author: USA, National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group Language: English. Number of References: 28 ref. Registry Number: 308067-57-4. Subject Subsets: Public Health N2 - To describe the epidemiological, clinical, radiological, laboratory and treatment characteristics of acute pneumonia and its association with mortality in HIV-infected children, data were collected from 376 such children who took part in a trial of intravenous immunoglobulin (IVIG) for infection prophylaxis. The trial took place in the USA and Puerto Rico during 1988-91. CD4+ percentage was measured and HIV RNA was assessed on stored sera collected at baseline and every 3 months. Mortality was recorded during the trial and updated to 1996. All reported physician-diagnosed pneumonia episodes underwent blinded review for trial endpoint classification as acute (new radiological findings and presence of clinical symptoms) or non-acute. On blinded clinical trial endpoint review of all reported pneumonia episodes (n=281), only 47% were classified as acute. 131 episodes of acute pneumonia were reported in 93 children (47 in 31 IVIG and 84 in 62 placebo patients, P<0.01). The incidence of acute pneumonia was 24 episodes per 100 patient years. Findings associated with an acute bacterial process were uncommon (leukocytosis ≥15 000/mm³ in 21% and fever ≥103°F in 32% of episodes). Multiple acute episodes occurred in 34% of the children and were associated with increased risk of mortality in a univariate analysis (risk ratio, 2.1; 95% confidence interval, 1.3-3.4, P=0.002), but in a multivariate model only baseline HIV RNA copy number and CD4+ percentage remained independently associated with mortality (relative risk, 2.0 and 1.4, respectively, P<0.001). It is concluded that acute pneumonia was a common occurrence in HIV-infected children and was associated with long term mortality risk. It is suggested that multiple episodes of acute pneumonia represent a marker of progressive disease and immunological dysfunction rather than being causally associated with increased long term mortality. KW - acute infections KW - characteristics KW - children KW - clinical aspects KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunoglobulins KW - mortality KW - pneumonia KW - prognosis KW - prophylaxis KW - viral diseases KW - Puerto Rico KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - clinical picture KW - death rate KW - gamma-globulins KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune globulins KW - Porto Rico KW - severe infections KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000959&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. AU - Esposito, D. AU - Craigie, R. JO - EMBO Journal JF - EMBO Journal Y1 - 1998/// VL - 17 IS - 19 SP - 5832 EP - 5843 SN - 0261-4189 AD - Esposito, D.: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, 5 Center Drive MSC0560, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014273. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 9007-49-2. N2 - The results highlight the involvement of the disordered loop of the integrase core domain, specifically residues Q148 and Y143, in binding to the terminal portion of the viral DNA ends. In addition, positions upstream in the LTR termini were identified which interact with the C-terminal domain of integrase, providing evidence for the role of that domain in stabilization of viral DNA binding. Finally, a region centred 12 bases from the viral DNA terminus was identified which appears essential for viral end DNA binding in the presence of magnesium, but not in the presence of manganese, suggesting a differential effect of divalent cations on sequence-specific binding. These results help to define important regions of contact between integrase and viral DNA, and assist in the formulation of a molecular model of this vital interaction. KW - binding KW - DNA KW - enzymes KW - human diseases KW - integration KW - interactions KW - proteins KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014273&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Statistical issues for HIV surrogate endpoints: point/counterpoint. An NIAID workshop. AU - Albert, J. M. AU - Ioannidis, J. P. A. AU - Reichelderfer, P. AU - Conway, B. AU - Coombs, R. W. AU - Crane, L. AU - Demasi, R. AU - Dixon, D. O. AU - Flandre, P. AU - Hughes, M. D. AU - Kalish, L. A. AU - Larntz, K. AU - Lin DanYu AU - Marschner, I. C. AU - Muñoz, A. AU - Murray, J. AU - Neaton, J. AU - Pettinelli, C. AU - Rida, W. AU - Taylor, J. M. G. AU - Welles, S. L. JO - Statistics in Medicine JF - Statistics in Medicine Y1 - 1998/// VL - 17 IS - 21 SP - 2435 EP - 2462 SN - 0277-6715 AD - Albert, J. M.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6003 Executive Boulevard, Bethesda, MD 20892-7620, USA. N1 - Accession Number: 19982014573. Publication Type: Journal Article. Language: English. Registry Number: 63231-63-0. KW - acquired immune deficiency syndrome KW - CD4+ lymphocytes KW - disease course KW - disease markers KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - leukocyte count KW - RNA KW - statistical analysis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4+ cells KW - cell count KW - chemotherapy KW - disease progression KW - human immunodeficiency virus KW - ribonucleic acid KW - statistical methods KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014573&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Longitudinal HIV-1 RNA levels in a cohort of homosexual men. AU - O'Brien, T. R. AU - Rosenberg, P. S. AU - Yellin, F. AU - Goedert, J. J. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1998/// VL - 18 IS - 2 SP - 155 EP - 161 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, EPN 434, 6130 Executive Boulevard, Rockville, MD 20852, USA. N1 - Accession Number: 19982009710. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 63231-63-0. N2 - Reverse transcriptase polymerase chain reaction (RT-PCR) was used to examine changes in serum HIV-1 RNA levels in 111 HIV-1-infected homosexual men during the period from 1982 to 1992 and their relation to clinical outcomes. HIV-1 RNA levels increased by a median of 0.08 log10 copies/ml/year (P = 0.0001). HIV-1 RNA levels rose either gradually or abruptly for the majority of subjects; 41% had no increase. Among subjects surviving at least 8 years, HIV-1 RNA was stable during the first 4 years after seroconversion (median, 0.00 log10 copies/ml/year), but rose in years 5 through 8 (median, 0.06 log10 copies /ml/year; P =0.04). The annual HIV-1 RNA level was more predictive of AIDS (relative hazard [RH], 1.75 per 0.5 log difference; 95% CI 1.38-2.21; likelihood ratio [LR], 26.2) than the initial level alone (RH, 1.39; 95% CI, 1.10-1.76; LR, 8.5). It is concluded that most HIV-1-infected persons lack a long-term viral setpoint and that failure to account for evolution of the viral level can lead to underestimation of the risk of progression. KW - acquired immune deficiency syndrome KW - disease course KW - homosexuality KW - human diseases KW - men KW - RNA KW - survival KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - disease progression KW - homosexuals KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009710&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. AU - Kharroubi, A. el AU - Piras, G. AU - Zensen, R. AU - Martin, M. A. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1998/// VL - 18 IS - 5 SP - 2535 EP - 2544 SN - 0270-7306 AD - Kharroubi, A. el: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19982008288. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9007-49-2. N2 - The regulation of HIV-1 gene expression involves a complex interplay between cellular transcription factors, chromatin-associated proviral DNA, and the virus-encoded transactivator protein, Tat. This study shows that Tat transactivates the integrated HIV-1 long terminal repeat (LTR), even in the absence of detectable basal promoter activity, and this transcriptional activation is accompanied by chromatin remodelling downstream of the transcription initiation site, as monitored by increased accessibility to restriction endonucleases. However, with an integrated promoter lacking both Sp1 and NF-κB sites, Tat was unable to either activate transcription or induce changes in chromatin structure even when it was tethered to the HIV-1 core promoter upstream of the TATA box. Tat responsiveness was observed only when Sp1 or NF-κB was bound to the promoter, implying that Tat functions subsequent to the formation of a specific transcription initiation complex. Unlike Tat, NF-κB failed to stimulate the integrated transcriptionally silent HIV-1 promoter. Histone acetylation renders the inactive HIV-1 LTR responsive to NF-κB, indicating that a suppressive chromatin structure must be remodelled prior to transcriptional activation by NF-κB. Taken together, these results suggest that Sp1 and NF-κB are required for the assembly of transcriptional complexes on the integrated viral promoter exhibiting a continuum of basal activities, all of which are fully responsive to Tat. KW - DNA KW - gene expression KW - human diseases KW - human immunodeficiency viruses KW - promoters KW - structure KW - transactivation KW - transcription KW - transcription factors KW - Human immunodeficiency virus 1 KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - DNA transcription KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - nuclear factor kappaB KW - nuclear factors KW - promoter region KW - promoter sequences KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Modern drug development from traditional medicinal plants using radioligand receptor-binding assays. AU - Renuka Misra JO - Medicinal Research Reviews JF - Medicinal Research Reviews Y1 - 1998/// VL - 18 IS - 6 SP - 383 EP - 402 SN - 0198-6325 AD - Renuka Misra: National Institute on Aging, National Institutes of Health, Gerontology Research Center, Nathan Shock Drive, Baltimore, MD 21224 and Xechem, Inc., Research Laboratories, 100 Jersey Avenue, Bldg. B, Suite 310, New Brunswick, NJ 08901-3279, USA. N1 - Accession Number: 19990308273. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Registry Number: 9000-81-1, 9001-66-5, 9012-78-6, 56-12-2, 9011-97-6. Subject Subsets: Horticultural Science N2 - A number of traditionally used plant extracts and various "Ayurvedic medicines" that are highly valued in Ayurveda for antiaging, memory-enhancing, nerve tonic, anxiolytic, antiinflammatory and immunopotentiation, were screened using the National Institutes of Mental Health (NIMH) Synthetic Screening Program for scientific validation and the development of new leads of psychotherapeutic compounds using Radioligand Receptor Binding Assays (RRA). Crude methanolic extracts of plants are screened using approximately 40 different in vitro RRA (primarily from rat brain homogenates) and 6 enzyme assays including acetylcholine esterase, choline acetyltransferase, and monoamine oxidase (MAO), A and B. The total crude extracts of many of these plants showed potent selectivity to various receptors, especially γ-aminobutyric acid (GABAA), N-methyl-D-aspartic Acid (NMDA), and MAO receptors, which are presumed to be involved in mental disorders. The focus was on plants showing the highest displacement of GABA, cholecystokinin [pancreozymin] (CCK), NMDA, MAO, and benzodiazepines. Bioassay-guided fractionation of the most active extracts resulted in pure compounds which retained the original activity of the crude extract validating the folkloric use. A bioactivity-guided fractionation of Terminalia bellerica [T. bellirica] fruit extract led to the isolation of several pure compounds which retained the original activity of the crude extract for CCK and GABA receptors, with the exception of compound B3EA-6, which exhibited high affinity for neurokinin receptor (substance K ~ NK-1). The absolute structure of B3EA-6 has been established by X-ray crystallography. KW - acetylcholinesterase KW - amine oxidase (flavin-containing) KW - bioassays KW - brain KW - choline acetyltransferase KW - drugs KW - enzymes KW - esterases KW - gamma-aminobutyric acid KW - in vitro KW - medicinal plants KW - mental disorders KW - natural products KW - oxidoreductases KW - pancreozymin KW - plant extracts KW - receptors KW - screening KW - traditional medicines KW - India KW - rats KW - Terminalia bellirica KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Terminalia KW - Combretaceae KW - Myrtales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - cerebrum KW - cholecystokinin KW - drug plants KW - GABA KW - medicinal herbs KW - medicines KW - mental illness KW - monoamine oxidase KW - officinal plants KW - pharmaceuticals KW - psychiatric disorders KW - redox enzymes KW - screening tests KW - Plant Composition (FF040) KW - Non-wood Forest Products (KK540) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990308273&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. AU - Neuveut, C. AU - Low, K. G. AU - Maldarelli, F. AU - Schmitt, I. AU - Majone, F. AU - Grassmann, R. AU - Jeang KuanTeh JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1998/// VL - 18 IS - 6 SP - 3620 EP - 3632 SN - 0270-7306 AD - Neuveut, C.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bldg 4, No. 302, 900 Rockville Pike, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19982008467. Publication Type: Journal Article. Language: English. Number of References: 90 ref. N2 - Taken together, the findings of this study suggest that Tax might activate cyclin D-cdk in a way that is separate from its ability to complex with p16INK4a. It is proposed that Tax has two effects: inactivation of a CDK inhibitor (i.e. p16INK4a) and activation of cyclin D-cdk through a CKI-independent route(s). KW - cell cycle KW - cyclins KW - human diseases KW - pathogenesis KW - T lymphocytes KW - Tax protein KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-γ) promoter and subsequent downregulation of IFN-γ production. AU - Mikovits, J. A. AU - Young, H. A. AU - Vertino, P. AU - Issa, J. P. J. AU - Pitha, P. M. AU - Turcoski-Corrales, S. AU - Taub, D. D. AU - Petrow, C. L. AU - Baylin, S. B. AU - Ruscetti, F. W. JO - Molecular and Cellular Biology JF - Molecular and Cellular Biology Y1 - 1998/// VL - 18 IS - 9 SP - 5166 EP - 5177 SN - 0270-7306 AD - Mikovits, J. A.: PO Box B, Bldg. 567, Rm 253, National Cancer Institute-Frederick Cancer Research and Development Center, Frederic, MD 21702-1201, USA. N1 - Accession Number: 19982013174. Publication Type: Journal Article. Language: English. Number of References: 87 ref. Registry Number: 9007-49-2, 9008-11-1, 308079-78-9. N2 - This study shows that acute infection of cells with HIV-1 results in (i) increased DNA methyltransferase expression and activity, (ii) an overall increase in methylation of DNA in infected cells, and (iii) the de novo methylation of a CpG dinucleotide in the IFN-γ gene promoter, resulting in the subsequent downregulation of expression of this cytokine. The introduction of an antisense methyltransferase construct into lymphoid cells resulted in markedly decreased methyltransferase expression, hypomethylation throughout the IFN-γ gene, and increased IFN-γ production, demonstrating a direct link between methyl-transferase and IFN-γ gene expression. The ability of increased DNA methyltransferase activity to downregulate the expression of genes like the IFN-γ gene may be one of the mechanisms for dysfunction of T cells in HIV-1-infected individuals. KW - acute infections KW - cytokines KW - DNA KW - gene expression KW - genes KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - interferon KW - messenger RNA KW - methylation KW - pathogenesis KW - pathogens KW - promoters KW - T lymphocytes KW - tumour necrosis factor KW - viral diseases KW - Human immunodeficiency virus 1 KW - Retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - cachectin KW - cachexin KW - deoxyribonucleic acid KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - mRNA KW - promoter region KW - promoter sequences KW - severe infections KW - T cells KW - tumor necrosis factor KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013174&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diagnosis of invasive fungal infections: advances in nonculture systems. AU - Walsh, T. J. AU - Chanock, S. J. JO - Current Clinical Topics in Infectious Diseases JF - Current Clinical Topics in Infectious Diseases Y1 - 1998/// VL - 18 SP - 101 EP - 153 AD - Walsh, T. J.: Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19991200083. Publication Type: Journal Article. Language: English. Number of References: 277 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The current state of conventional methodologies is reviewed and the current status and future potential of non-culture methods are discussed, highlighting both their technical and clinical implications. The diagnosis of infections caused by Candida spp., Cryptococcus neoformans, Trichosporon spp., agents of endemic mycoses, Aspergillus spp., agents of zygomycosis, Fusarium spp. and Pseudallescheria boydii is considered. KW - aspergillosis KW - candidosis KW - cryptococcosis KW - diagnosis KW - human diseases KW - mycoses KW - reviews KW - zygomycosis KW - Aspergillus KW - Cryptococcus neoformans KW - Fusarium KW - man KW - Pseudallescheria boydii KW - Trichosporon KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporonaceae KW - candidiasis KW - european blastomycosis KW - fungus KW - Hyphomycetes KW - phycomycosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200083&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A preliminary study of factors associated with psychological adjustment and disease course in school-age children infected with the human imunodeficiency virus. AU - Moss, H. AU - Bose, S. AU - Wolters, P. AU - Brouwers, P. JO - Journal of Developmental and Behavioral Pediatrics JF - Journal of Developmental and Behavioral Pediatrics Y1 - 1998/// VL - 19 IS - 1 SP - 18 EP - 25 SN - 0196-206X AD - Moss, H.: HIV/AIDS Malignancy Branch, National Cancer Institute, Bldg 10, 13N240, Bethesda, MD 20892-1928, USA. N1 - Accession Number: 19982004281. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - This study consisted of a longitudinal examination (baseline and approximately 2-yr follow-up) of factors associated with psychological adjustment in a sample of 24 school-age children infected with HIV. Measures of depression, anxiety, and self-concept were administered to the children, and measures of behavioural problems, social functioning, and negative life events were administered to the parents. Generally, psychological adjustment seemed stable, though a decrease in positive social self-concept over time was observed. Negative life events were significantly associated with greater adverse psychological and behavioural outcomes at both baseline and follow-up. An additional component to the study investigated factors associated with survival. Examination of an additional 5 children who died within 12 months of baseline indicated that they experienced significantly more adverse life events, were less resilient, and had greater disease progression. The sample size was small and requires that these findings be considered as preliminary and suggestive rather than conclusive. KW - children KW - disease course KW - follow up KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - psychosocial aspects KW - survival KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004281&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infant feeding and risk of mother-to-child transmission of HIV-1 in São Paulo State, Brazil. AU - Tess, B. H. AU - Rodrigues, L. C. AU - Newell, M. L. AU - Dunn, D. T. AU - Lago, T. D. G. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1998/// VL - 19 IS - 2 SP - 189 EP - 194 AD - Tess, B. H.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6130 Executive Boulevard, EPN/434, Rockville, MD 20852, USA. N1 - Accession Number: 19982014118. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition; Dairy Science KW - breast feeding KW - epidemiology KW - human diseases KW - human milk KW - infant feeding KW - infants KW - maternal transmission KW - risk factors KW - Brazil KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - breast milk KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Milk and Dairy Produce (QQ010) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014118&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preventing discrimination against volunteers in prophylactic HIV vaccine trials: lessons from a phase II trial. AU - Sheon, A. R. AU - Wagner, L. AU - McElrath, M. J. AU - Keefer, M. C. AU - Zimmerman, E. AU - Israel, H. AU - Berger, D. AU - Fast, P. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1998/// VL - 19 IS - 5 SP - 519 EP - 526 AD - Sheon, A. R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. N1 - Accession Number: 19992004144. Publication Type: Journal Article. Language: English. Number of References: 39 ref. N2 - Frequency of HIV testing and discrimination among participants in a preventive phase II HIV vaccine trial in the USA are described. 266 vaccine trial volunteers were eligible; 247 participated in a confidential survey. 63 volunteers (26% of respondents) reported 185 HIV tests during the prior 12 to 24 months; most tests were for other research studies, health care, insurance, incarceration, or employment. Only 5 volunteers reported having positive HIV test results. Volunteers reported 99 adverse social incidents or problems, 53 of which were related to the trial. The most common type of event occurred when volunteers disclosed their trial participation and were mistakenly presumed to be infected with HIV. Few reported difficulty obtaining insurance, job loss, and inadvertent disclosure of their participation in the trial. In this vaccine trial, few serious social harms were reported. It is concluded that those who conduct HIV tests for insurance, employment, health care, or other reasons should be made aware that HIV vaccines can cause false-positive HIV test results. Those planning future trials must continue to provide needed support to volunteers. Social harms should be monitored with the same vigilance accorded to physical harms. KW - clinical trials KW - discrimination KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - surveys KW - vaccines KW - volunteers KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004144&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet. AU - Snyderwine, E. G. AU - Davis, C. D. AU - Schut, H. A. J. AU - Roberts-Thomson, S. J. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1998/// VL - 19 IS - 7 SP - 1209 EP - 1215 SN - 0143-3334 AD - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Building 37, Room 3C28, NIH, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19981418176. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition N2 - A carcinogenic dose-regimen of oral amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (75 mg/kg, 10 doses, once per day) was administered to 43-day old female Sprague-Dawley rats. The rats were then placed on a defined high fat (23.5% corn [maize] oil) or low fat (5% corn oil) diet for up to 6 weeks. The percentage of proliferating cells in terminal end bud (TEB) epithelial structures of the rat mammary gland was examined by proliferating cell nuclear antigen staining, mammary gland architecture by whole mounting, and PhIP-DNA adduct levels in mammary epithelial cells by the 32P-post-labelling assay. Immediately after dosing, the percentage of proliferating epithelial cells in TEBs was significantly higher in PhIP-treated than control rats receiving vehicle only (7.5±0.9% (n=99) vs. 4.2±0.6% (n=127), respectively). The mammary glands of PhIP-treated rats showed a significantly lower density of alveolar buds (ABs) and a higher density of TEBs than control rats, which suggests that PhIP exposure partially inhibited the normal glandular differentiation of TEBs to ABs. After 6 weeks on the diet, proliferation in TEBs was higher in rats given PhIP plus a high fat diet than in rats given vehicle plus a low fat diet. The mammary glands from rats on a high fat diet also showed a higher density of TEBs than those from rats on a low fat diet (2.08±0.34% vs. 1.04±0.20%, respectively (n=6)). PhIP-DNA adduct levels were relatively high in mammary epithelial cells of treated rats. At 3 h after the last dose of PhIP, DNA adduct levels (relative adduct labelling (RAL) × 107) were 10.5±1.7 (n=8) and 0.9±0.2 (n=7) in epithelial cells isolated from mammary gland and in the liver, respectively. DNA adduct removal rates from the mammary gland were not different between rats on the high fat and low fat diets. Adducts were still detected after 6 weeks on either diet. Thus, events that occurred prior to neoplasia in the mammary glands of PhIP-treated rats include formation of PhIP-DNA adducts at relatively high levels, and enhanced proliferation in TEBs (putative sites of origin of mammary gland carcinomas) and partial inhibition of TEB differentiation. The high fat diet, a promoter of PhIP-induced mammary gland carcinogenesis, appeared to sustain the proliferative effect of PhIP in mammary gland TEBs at a time when PhIP-DNA adducts are still detectable. KW - carcinogenesis KW - carcinogens KW - cell division KW - DNA KW - epithelium KW - fat KW - liver KW - maize oil KW - mammary gland neoplasms KW - mammary glands KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - corn oil KW - deoxyribonucleic acid KW - karyokinesis KW - mammary tumour KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418176&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Public health in central and eastern Europe and the role of environmental pollution. AU - Little, R. E. JO - Annual Review of Public Health JF - Annual Review of Public Health Y1 - 1998/// VL - 19 SP - 153 EP - 172 SN - 0163-7525 AD - Little, R. E.: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27514, USA. N1 - Accession Number: 19992001744. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - The central and eastern European countries that composed the former Eastern Bloc have experienced an alarming decline in public health since the dissolution of the Soviet Union. Death rates have increased in most age groups. Life expectancy, especially among males, has decreased in many countries; in Russia, male life expectancy dropped by 6 years between 1989 and 1994. By 2020, these countries are projected to have smaller increases in life expectancy than any other geographical region. The conditions responsible for the excess mortality are cardiovascular disease, cancer, and injuries among adults. The major factors in the sharp increase are poverty, social disintegration, and crime, overlaid on historically high rates of smoking, alcohol use, and psychosocial stress. Environmental pollution, although common and sometimes severe in the former Eastern Bloc is another cause of the sharp decline in public health since 1989. KW - cardiovascular diseases KW - human diseases KW - morbidity KW - mortality KW - neoplasms KW - pollution KW - public health KW - trauma KW - Central Europe KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Europe KW - cancers KW - death rate KW - environmental pollution KW - traumas KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001744&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. AU - Lauro, D. AU - Kido, Y. AU - Castle, A. L. AU - Zarnowski, M. J. AU - Hayashi, H. AU - Ebina, Y. AU - Accili, D. JO - Nature Genetics JF - Nature Genetics Y1 - 1998/// VL - 20 IS - 3 SP - 294 EP - 298 SN - 1061-4036 AD - Lauro, D.: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19990106730. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition; Animal Breeding N2 - Transgenic mice were generated which were insulin-resistant in skeletal muscle and adipose tissue. The mice developed all the prodromal features of type 2 diabetes but, despite the compounded effect of peripheral insulin resistance and a mild impairment of β cell function, failed to become diabetic. It is suggested that the primary site(s) of insulin resistance in diabetes needs to be re-examined. KW - adipose tissue KW - animal models KW - diabetes KW - genetically engineered organisms KW - glucose tolerance KW - insulin KW - liver KW - receptors KW - skeletal muscle KW - transgenic animals KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood sugar tolerance KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990106730&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP119) and their role in immunity to malaria. AU - Tian JingHui AU - Good, M. F. AU - Chakrit Hirunpetcharat AU - Sanjai Kumar AU - Ling, I. T. AU - Jackson, D. AU - Cooper, J. AU - Lukszo, J. AU - Coligan, J. AU - Ahlers, J. AU - Saul, A. AU - Berzofsky, J. A. AU - Holder, A. A. AU - Miller, L. H. AU - Kaslow, D. C. JO - Parasite Immunology JF - Parasite Immunology Y1 - 1998/// VL - 20 IS - 6 SP - 263 EP - 278 SN - 0141-9838 AD - Tian JingHui: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980808687. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Protozoology N2 - To determine whether MSP119-specific effector T cells can control parasitaemia, the specificity of T cells induced following immunization of mice with recombinant forms of Plasmodium yoelii MSP119 was analysed. There was no evidence that effector T cells were capable of protection since: immunization of mice with yeast-expressed MSP119, but not defined epitopes, was able to induce protection, and long-term MSP119-specific CD4+ T cell lines were incapable of adoptively transferring protection. In contrast, priming mice with the T cell epitopes resulted in a rapid anamnestic antibody response to MSP119 after either challenge with MSP119 or parasite. It is concluded that MSP119 contains multiple T cell epitopes but such epitopes are the targets of helper T cells for antibody response but not of identified effector T cells capable of controlling parasitaemia. KW - antigens KW - epitopes KW - experimental infections KW - immune response KW - immunity KW - immunization KW - laboratory animals KW - merozoites KW - parasitaemia KW - parasites KW - recombinant proteins KW - surface proteins KW - T lymphocytes KW - mice KW - Plasmodium yoelii KW - protozoa KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - antigenic determinants KW - antigenicity KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - membrane proteins KW - merozoite surface protein 1 KW - parasitemia KW - T cells KW - T helper cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808687&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification of anti-HIV lignans from Larrea tridentata by pH-zone-refining countercurrent chromatography. AU - Ma, Y. AU - Qi, L. AU - Gnabre, J. N. AU - Huang, R. C. C. AU - Chou, F. E. AU - Ito, Y. JO - Journal of Liquid Chromatography & Related Technologies JF - Journal of Liquid Chromatography & Related Technologies Y1 - 1998/// VL - 21 IS - 1/2 SP - 171 EP - 181 AD - Ma, Y.: Laboratory of Biomedical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Rm 7N322, Bldg. 10, 10 Center Drive MSC 1676, Bethesda, MD 20892-1676, USA. N1 - Accession Number: 19980304374. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - Anti-HIV lignans were purified from a dichloromethane extract of Larrea tridentata leaves by high-speed countercurrent chromatography (CCC) using pH-zone-refining CCC. When 10-20 g of the crude extract was put onto a column filled with methyl tert-butyl ether containing 25 mM trifluoroacetic acid, and eluted stepwise with aqueous 0, 50 and 100 mM NaOH, NDGA (nordihydroguaiaretic acid) and its monomethyl esters were separated as rectangular 'peaks' associated with specific pH zones. The method was also successfully applied to synthetic lignans, resulting in resolution of NDGA and its mono- and dimethyl esters. KW - antiviral agents KW - antiviral plants KW - chromatography KW - esters KW - human diseases KW - human immunodeficiency viruses KW - leaves KW - lignans KW - pH KW - plant extracts KW - purification KW - separation KW - Larrea tridentata KW - plants KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Larrea KW - Zygophyllaceae KW - Sapindales KW - Geraniales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - human immunodeficiency virus KW - hydrogen ion concentration KW - potential of hydrogen KW - separating KW - Techniques and Methodology (ZZ900) KW - Non-food/Non-feed Plant Products (SS200) KW - Plant Composition (FF040) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980304374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular alterations in sarcomas. AU - Goletz, T. J. AU - Worley, B. S. AU - Berzofsky, J. A. AU - Mackall, C. L. AU - Helman, L. J. JO - Veterinary Cancer Society Newsletter JF - Veterinary Cancer Society Newsletter Y1 - 1998/// VL - 22 IS - 4 SP - 9 EP - 11 AD - Goletz, T. J.: Pediatric Oncology Branch, Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992203383. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Veterinary Science KW - chromosome translocation KW - cytogenetics KW - neoplasms KW - sarcoma KW - cancers KW - interchange KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992203383&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine. AU - Childs, R. AU - Sanchez, C. AU - Engler, H. AU - Preuss, J. AU - Rosenfeld, S. AU - Dunbar, C. AU - Rhee, F. van AU - Plante, M. AU - Phang, S. AU - Barrett, A. J. JO - Bone Marrow Transplantation JF - Bone Marrow Transplantation Y1 - 1998/// VL - 22 IS - 9 SP - 889 EP - 893 SN - 0268-3369 AD - Childs, R.: Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992000654. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health N2 - Between September 1993 and January 1997, 56 patients received a T cell-depleted, HLA-identical sibling bone marrow transplant (BMT) for haematological malignancy at a hospital in the USA. Nine of 56 (20% actuarial) developed haemorrhagic cystitis (HC) 15-368 days post BMT. Haematuria was severe and prolonged (median duration 18 days). In 8 patients (89%), a viral aetiology was confirmed (4 adenovirus, 4 polyomavirus). HC was associated with significant morbidity, with all patients requiring continuous bladder irrigation and transfusion support for blood loss and thrombocytopenia. HC occurring before day 100 was significantly associated with a reduction in long-term survival: 1/7 (14.3%) patients developing HC before day 100 became long-term survivors vs 21/49 (42.8%) without HC by day 100 (P=0.034). In univariate analysis, HC was associated with a diagnosis of multiple myeloma (P=0.02). There was a trend towards a higher incidence of HC in patients reactivating cytomegalovirus (CMV) compared with those remaining CMV negative (18.4 vs 5.5% respectively, P=0.17). HC was not associated with graft-versus-host disease, or with the transplant dose of CD34+ progenitors or CD3+ cells, patient age or sex. Life-threatening, viral-induced HC and the unusually high incidence of adenovirus-induced HC may have been caused by immune deficiency associated with T cell depletion in this series. KW - bone marrow transplant KW - clinical aspects KW - cystitis KW - haematuria KW - human diseases KW - immunocompromised hosts KW - immunological deficiency KW - infections KW - opportunistic infections KW - survival KW - T lymphocytes KW - transplant recipients KW - urinary tract KW - urinary tract infections KW - viral diseases KW - USA KW - human adenovirus KW - Human herpesvirus 5 KW - man KW - Polyomavirus KW - Mastadenovirus KW - Adenoviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Polyomaviridae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - hematuria KW - human cytomegalovirus KW - immune deficiency KW - immunodeficiency KW - recipients KW - T cells KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000654&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of nitric oxide synthase isoforms in normal human tracheobronchial epithelial cells in vitro: dependence on retinoic acid and the state of differentiation. AU - Norford, D. AU - Koo, J. S. AU - Gray, T. AU - Alder, K. AU - Nettesheim, P. JO - Experimental Lung Research JF - Experimental Lung Research Y1 - 1998/// VL - 24 IS - 3 SP - 355 EP - 366 SN - 0190-2148 AD - Norford, D.: Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 19991402068. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - The retinoic acid (RA) and differentiation dependence of constitutive expression of the nitric oxide synthase (NOS) isoforms, iNOS, eNOS, and bNOS, was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in cultured, normal, human, tracheobronchial epithelial (NHTBE) cells. In the presence of RA (RA+), early passage NHTBE cells grown in air-liquid interface (ALI) cultures undergo mucous differentiation; in the absence of RA (RA-), they undergo metaplastic squamous differentiation. Under both conditions the respective differentiated phenotype develops around day 10 of culture. iNOS mRNA levels were much higher in RA+ cultures, expressing the mucous phenotype, than in RA- cultures, expressing the metaplastic squamous phenotype. In contrast, eNOS mRNA levels were much higher in RA- cultures than in RA+ cultures. Expression of bNOS was not significantly affected by the RA status. The pattern of expression of NOS isoforms was then studied during the course of development of the two cellular phenotypes. During the early stages of differentiation, expression of iNOS (RA+) and eNOS (RA-) was very low, indicating that the expression of these two isoforms was not only dependent on the presence or absence of RA, but also on the degree of differentiation. The differentiation dependence of bNOS mRNA was less obvious. Four days of RA treatment of RA- cultures, which reverses the squamous phenotype and restores mucous differentiation, induced iNOS expression in a concentration-dependent manner. eNOS expression was depressed by 10-8M RA, while bNOS mRNA levels were slightly reduced by 10-6M RA. No NOS proteins were detected in unstimulated RA+ and RA- cultures. iNOS protein was induced by cytokine treatment in RA+ cultures in contrast to iNOS and bNOS protein levels, which were unaffected. These studies show that constitutive expression of the NOS isoforms is differentially regulated and that iNOS and eNOS mRNA levels are dependent on the stage of mucous and squamous differentiation, respectively. bNOS expression was only marginally affected by the RA or differentiation status. KW - cell cultures KW - differentiation KW - epithelium KW - gene expression KW - lungs KW - retinoic acid KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - nitric oxide synthase KW - tretinoin KW - vitamin A acid KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402068&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Why is docosahexaenoic acid essential for nervous system function? AU - Mitchell, D. C. AU - Gawrisch, K. AU - Litman, B. J. AU - Salem, N., Jr. JO - Biochemical Society Transactions JF - Biochemical Society Transactions Y1 - 1998/// VL - 26 IS - 3 SP - 365 EP - 370 SN - 0300-5127 AD - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, DICBR, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Room 158, Rockville, MD 20852. USA. N1 - Accession Number: 19981415250. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 25167-62-8. Subject Subsets: Human Nutrition N2 - The essentiality of docosahexaenoic acid is discussed. KW - development KW - docosahexaenoic acid KW - essential fatty acids KW - infants KW - nervous system KW - polyenoic fatty acids KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - polyunsaturated fatty acids KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415250&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Successful medical management of isolated renal zygomycosis: case report and review. AU - Weng, D. E. AU - Wilson, W. H. AU - Little, R. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 26 IS - 3 SP - 601 EP - 605 SN - 1058-4838 AD - Weng, D. E.: Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19991201550. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The medical management of isolated renal zygomycosis in 42-year-old man from the USA, with AIDS, during chemotherapy for AIDS-related lymphoma, is described. After initial presentation during the first cycle of chemotherapy, the infection was contained within the kidney following recovery of the neutrophil count without medical or surgical intervention. Cultures of tissue specimens grew Rhizopus microsporus. Since the patient was not considered to be a candidate for nephrectomy, the infection was treated with amphotericin B lipid complex during subsequent chemotherapy. Neutropenia was minimized by the addition of cytokine support therapy with granulocyte colony-stimulating factor and reduced doses of chemotherapy. Following this strategy, his lymphoma completely resolved, and renal zygomycosis was controlled. The patient remained in complete remission for 18 months without evidence of progressive fungal infection. Previously reported cases of renal zygomycosis are discussed. KW - acquired immune deficiency syndrome KW - amphotericin B KW - application methods KW - case reports KW - clinical aspects KW - cytokines KW - drug formulations KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - kidneys KW - lipids KW - lymphoma KW - men KW - neutropenia KW - opportunistic infections KW - prognosis KW - zygomycosis KW - USA KW - man KW - Mucoraceae KW - Rhizopus KW - Rhizopus microsporus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mucoraceae KW - Mucorales KW - Mucoromycotina KW - Zygomycota KW - fungi KW - Rhizopus KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - chemotherapy KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - lipins KW - phycomycosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201550&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Burkholderia pseudomallei infection in a Puerto Rican patient with chronic granulomatous disease: case report and review of occurrences in the Americas. AU - Dorman, S. E. AU - Gill, V. J. AU - Gallin, J. I. AU - Holland, S. M. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 26 IS - 4 SP - 889 EP - 894 SN - 1058-4838 AD - Dorman, S. E.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982008000. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Tropical Diseases N2 - Burkholderia species, notably B. cepacia and B. gladioli, are important pathogens in patients with chronic granulomatous disease (CGD). B. pseudomallei, the causative agent of melioidosis, is endemic in Southeast Asia and northern Australia but is a rare pathogen in other parts of the world. The occurrence of B. pseudomallei infection in a Puerto Rican patient with CGD is described. This is one of only a small number of documented cases of melioidosis autochthonous to the Americas and is the first reported case of B. pseudomallei infection in a CGD patient from the Americas. It is concluded that B. pseudomallei, like B. cepacia and B. gladioli, should be considered a potential pathogen in patients with CGD and that melioidosis should be considered in the differential diagnosis for ill residents of or travellers to Puerto Rico. KW - case reports KW - human diseases KW - melioidosis KW - Puerto Rico KW - Burkholderia pseudomallei KW - man KW - Burkholderia KW - Burkholderiaceae KW - Burkholderiales KW - Betaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - bacterium KW - Berkholderia KW - chronic granulomatous disease KW - Porto Rico KW - Pseudomonas pseudomallei KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008000&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine. AU - Silva, A. E. AU - McMahon, B. J. AU - Parkinson, A. J. AU - Sjogren, M. H. AU - Hoofnagle, J. H. AU - Bisceglie, A. M. di JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 26 IS - 4 SP - 895 EP - 897 SN - 1058-4838 AD - Silva, A. E.: Hepatitis Studies Section, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982008001. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 9007-49-2. N2 - Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only 5 persons, 4 of whom remained positive during retesting. Most persons had a primary antibody response with 3 doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA. KW - antibodies KW - antigens KW - core proteins KW - disease markers KW - DNA KW - hepatitis B KW - human diseases KW - immune response KW - immunization KW - serology KW - vaccination KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenicity KW - deoxyribonucleic acid KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008001&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - AIDS-associated atypical Pneumocystis carinii pneumonia revisited. AU - Groll, A. H. AU - Keul, H. G. AU - Brodt, R. AU - Schneider, M. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 26 IS - 4 SP - 1005 EP - 1006 SN - 1058-4838 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19982007170. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A retrospective review of postmortem examination results of 359 AIDS patients who died at the University Hospital, Frankfurt, Germany, during 1982-92, demonstrated P. carinii pneumonia in 78 (22%) cases. Atypical presentations were recorded in 14 cases (during 1989-92), including tissue necrosis, cavitation, honeycombing and small granuloma-like lesions were first observed in 1989, and their relative prevalence reached 40% during 1989-92. Foci of necrotizing P. carinii infection were present in lymph nodes (4 cases) and/or various parenchymatous organs (3). Clinically atypical P. carinii pneumonia was associated with very low CD4+ lymphocyte counts, spontaneous pneumothoraces, one or more prior episodes of P. carinii pneumonia, a history of other significant pulmonary complications an a high prevalence of concomitant pulmonary cytomegalovirus infection at postmortem examination. Nine of the 14 patients with atypical P. carinii pneumonia had received aerosolized pentamidine prophylaxis for a mean of 16 months before death. KW - acquired immune deficiency syndrome KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infections KW - lungs KW - mycoses KW - Pneumocystis carinii pneumonia KW - pneumocystosis KW - pneumonia KW - postmortem examinations KW - Germany KW - fungi KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Western Europe KW - Europe KW - AIDS KW - autopsy KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - postmortem inspections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007170&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. AU - Walsh, T. J. AU - Hiemenz, J. W. AU - Seibel, N. L. AU - Perfect, J. R. AU - Horwith, G. AU - Lee, L. AU - Silber, J. L. AU - DiNubile, M. J. AU - Reboli, A. AU - Bow, E. AU - Lister, J. AU - Anaissie, E. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 26 IS - 6 SP - 1383 EP - 1396 SN - 1058-4838 AD - Walsh, T. J.: National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202288. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The safety and antifungal efficacy of amphotericin B lipid complex (ABLC) were evaluated in 556 cases of invasive fungal infection treated through an open-label, single-patient, emergency-use study of patients from the USA, who were refractory to or intolerant of conventional antifungal therapy. All 556 treatment episodes were evaluable for safety. During the course of ABLC therapy, serum creatinine levels significantly decreased from baseline (P<0.02). Among 162 patients with serum creatinine values ≥2.5 mg/dl at the start of ABLC therapy (baseline), the mean serum creatinine value decreased significantly from the 1st week until the 6th week (P<0.0003). Among the 291 mycologically confirmed cases evaluable for therapeutic response, there was a complete or partial response to ABLC in 167 (57%), including 42% (55) of 130 cases of Aspergillus infection, 67% (28) of 42 cases of disseminated Candida infection, 71% (17) of 24 cases of zygomycosis, and 82% (9) of 11 cases of Fusarium infection. Response rates varied according to the pattern of invasive fungal infection, underlying condition, and reason for enrolment (intolerance vs. progressive infection). These results support the use of ABLC in the treatment of invasive fungal infections in patients who are intolerant of or refractory to conventional antifungal therapy. KW - amphotericin B KW - antifungal agents KW - application methods KW - aspergillosis KW - candidosis KW - drug formulations KW - drug therapy KW - efficacy KW - fusariosis KW - human diseases KW - infections KW - lipids KW - safety KW - zygomycosis KW - USA KW - Aspergillus KW - Candida KW - Fusarium KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - candidiasis KW - chemotherapy KW - fungistats KW - fungus KW - fusarioses KW - Hyphomycetes KW - lipins KW - phycomycosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Flucytosine monotherapy for cryptococcosis. AU - Hospenthal, D. R. AU - Bennett, J. E. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 27 IS - 2 SP - 260 EP - 264 SN - 1058-4838 AD - Hospenthal, D. R.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202610. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 2022-85-7. Subject Subsets: Medical & Veterinary Mycology N2 - Experience with flucytosine (5-FC) monotherapy in 27 patients with disseminated Cryptococcus neoformans infection treated at the Clinical Center of the National Institutes of Health, Bethesda, USA, during 1968-73 was reviewed. Patients were selected on the basis of criteria associated with good prognosis. In this group, 5-FC monotherapy resulted in cure in 8 cases and improvement in 2. Overall, response was seen in 10 (43%) of 23 evaluable patients. Therapy failed for 13 patients, including 5 who relapsed, 2 who had partial responses and 6 without response. Resistance was noted to have developed in isolates from 6 (50%) of 12 patients for whom therapy failed. It is concluded that although the 57% failure rate associated with 5-FC alone precludes its use as monotherapy, the study did show that this treatment is well tolerated and that failure is not invariably associated with development of resistance. KW - antifungal agents KW - cryptococcosis KW - drug therapy KW - efficacy KW - flucytosine KW - generalized infections KW - human diseases KW - infections KW - USA KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - 5-fluorocytosine KW - chemotherapy KW - european blastomycosis KW - fungistats KW - fungus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202610&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive pulmonary aspergillosis in a critically ill neonate: case report and review of invasive aspergillosis during the first 3 months of life. AU - Groll, A. H. AU - Jaeger, G. AU - Allendorf, A. AU - Herrmann, G. AU - Schloesser, R. AU - Loewenich, V. von JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 27 IS - 3 SP - 437 EP - 452 SN - 1058-4838 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991201260. Publication Type: Journal Article. Language: English. Number of References: 106 ref. Registry Number: 1397-89-3. N2 - A fatal case of invasive pulmonary Aspergillus infection is reported in a severely ill neonate from the USA and 43 additional cases of invasive aspergillosis reported during 1955-1996 that occurred during the first 3 months of life are also reviewed. 11 of the 44 patients had primary cutaneous aspergillosis, 10 had invasive pulmonary aspergillosis and 14 had disseminated disease. Most infections were nosocomial in origin. Prematurity (43%); proven chronic granulomatous disease (14%); and a complex of diarrhoea, dehydration, malnutrition and invasive bacterial infections (23%) accounted for the majority of underlying conditions. At least 41% of the patients had received corticosteroid therapy before diagnosis, but only 1 patient had been neutropenic. Among patients who received medical and/or surgical treatment, outcome was relatively favourable, with an overall survival rate of 73%. It is concluded that invasive aspergillosis may occur in neonates and young infants and warrants consideration under certain circumstances. Current therapeutic approaches consist of high-dose amphotericin B and appropriate surgical interventions. KW - amphotericin B KW - aspergillosis KW - bacterial diseases KW - case reports KW - diarrhoea KW - disseminated infections KW - generalized infections KW - human diseases KW - immunocompromised hosts KW - infections KW - lungs KW - malnutrition KW - neonates KW - nosocomial infections KW - opportunistic infections KW - predisposition KW - prematurity KW - reviews KW - survival KW - USA KW - Aspergillus KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - chronic granulomatous disease KW - diarrhea KW - fungus KW - hospital infections KW - Hyphomycetes KW - newborn infants KW - scouring KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201260&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Editorial response: primary cutaneous aspergillosis-an emerging infection among immunocompromised patients. AU - Walsh, T. J. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 27 IS - 3 SP - 453 EP - 457 SN - 1058-4838 AD - Walsh, T. J.: Immunocompromised Host Section, Bldg. 10, Rm 13N-240, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19982012377. Publication Type: Journal Article. Language: English. Number of References: 40 ref. KW - acquired immune deficiency syndrome KW - aspergillosis KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - mycoses KW - Aspergillus KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - AIDS KW - fungus KW - human immunodeficiency virus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012377&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. AU - You WeiCheng AU - Zhang Lian AU - Gail, M. H. AU - Ma JunLing AU - Chang YunSheng AU - Blot, W. J. AU - Li JiYou AU - Zhao CaiLin AU - Liu WeiDong AU - Li HuiQing AU - Hu YuanReng AU - Bravo, J. C. AU - Correa, P. AU - Xu GuangWei AU - Fraumeni, J. F., Jr. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1998/// VL - 27 IS - 6 SP - 941 EP - 944 SN - 0300-5771 AD - You WeiCheng: National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19992003639. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Tropical Diseases N2 - In order to evaluate determinants of intestinal metaplasia (IM) and dysplasia (DYS) in Cangshan County, Shandong County, China, a low risk area of gastric cancer (GC), a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. A dietary interview and measurement of serum H. pylori antibodies were performed. The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval (CI): 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% CI : 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR=3.2, 95% CI: 1.1-9.2) and IM/DYS (OR=7.8, 95% CI: 1.3-47.7). Consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. It is suggested that infection with H. pylori is a risk factor and garlic may be protective in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC. KW - alcohol intake KW - bacterial diseases KW - diet KW - epidemiology KW - garlic KW - gastritis KW - human diseases KW - lesions KW - medicinal plants KW - neoplasms KW - risk factors KW - seroprevalence KW - stomach KW - stomach cancer KW - surveys KW - China KW - Shandong KW - Allium sativum KW - Helicobacter pylori KW - man KW - Allium KW - Alliaceae KW - Liliaceae KW - Liliales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Helicobacter KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Northern China KW - China KW - alcohol consumption KW - bacterial infections KW - bacterioses KW - bacterium KW - cancers KW - drug plants KW - medicinal herbs KW - officinal plants KW - People's Republic of China KW - Shantung KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003639&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Primary cutaneous Acanthamoeba infection in a patient with AIDS. AU - Migueles, S. AU - Kumar, P. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1998/// VL - 27 IS - 6 SP - 1547 EP - 1548 SN - 1058-4838 AD - Migueles, S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11S231, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19990802330. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology KW - acquired immune deficiency syndrome KW - case reports KW - face KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - parasites KW - skin diseases KW - Maryland KW - USA KW - Acanthamoeba castellanii KW - man KW - protozoa KW - Acanthamoeba KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - dermatoses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells. AU - Belkaid, Y. AU - Butcher, B. AU - Sacks, D. L. JO - European Journal of Immunology JF - European Journal of Immunology Y1 - 1998/// VL - 28 IS - 4 SP - 1389 EP - 1400 SN - 0014-2980 AD - Belkaid, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 20000805916. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Protozoology N2 - Intracellular staining for cytokines and parasites, combined with 2-colour flow cytometric analyses, were used to examine the frequencies of IL-12-, TNF-α- and IL-6-producing macrophages in response to Leishmania major infection and/or activation with IFN-γ/lipopolysaccharide (LPS). Inflammatory macrophages were obtained from nonimmune granulomas, initiated by the injection of polyacrylamide microbeads (Bio-gel P-100) into subcutaneous pouches of 4 mouse strains (BALB/c, C3H/HeN, C57BL/6, CBA). Infection of inflammatory macrophages in vitro using metacyclic promastigotes produced identical effects on cytokine responses regardless of whether cells from genetically resistant or susceptible mouse strains were used: IL-12 was not produced in response to infection itself, virtually every infected cell lost its ability to produce IL-12 in response to IFN-γ/LPS, and the IL-6 response was partially inhibited, whereas the TNF-α response of infected cells was unimpaired. Low-multiplicity infection of inflammatory macrophages in vivo using either metacyclic promastigotes or tissue amastigotes also resulted in the complete and selective inhibition of IL-12 responses in infected cells. These data establish the physiologic relevance of prior observations regarding the selective impairment of IL-12 induction pathways in infected macrophages, and suggest a mechanisms for the delayed onset of cell-mediated control mechanisms that is typical of even self-limiting forms of leishmanial disease. KW - cytokines KW - experimental infections KW - immune response KW - immunological deficiency KW - in vitro KW - interferon KW - interleukin 12 KW - interleukin 6 KW - laboratory animals KW - lipopolysaccharides KW - macrophages KW - parasites KW - tumour necrosis factor KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - cachectin KW - cachexin KW - immune deficiency KW - immunity reactions KW - immunodeficiency KW - immunological reactions KW - tumor necrosis factor KW - Animal Models of Human Diseases (VV400) (New March 2000) KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000805916&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL-12 and up-regulation of Th2 cytokines that inhibit macrophage activation. AU - Oswald, I. P. AU - Caspar, P. AU - Wynn, T. A. AU - Scharton-Kersten, T. AU - Williams, M. E. AU - Hieny, S. AU - Sher, A. AU - James, S. L. JO - European Journal of Immunology JF - European Journal of Immunology Y1 - 1998/// VL - 28 IS - 6 SP - 1762 EP - 1772 SN - 0014-2980 AD - Oswald, I. P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990803305. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2. Subject Subsets: Helminthology N2 - In contrast to most inbred strains, P mice failed to develop significant resistance to Schistosoma mansoni infection as a result of vaccination with either irradiation-attenuated cercariae or schistosome antigens plus Bacillus Calmette Guérin, and this failure correlated with defects in macrophage larvicidal activity. Supernatant fluids from antigen-treated in vitro cultures of splenocytes from vaccinated P mice demonstrated less macrophage stimulatory activity than supernatants from cells of vaccine-responsive strains such as C57BL/6. This was not due either to diminished production of the macrophage-activating cytokine interferon (IFN)-γ by P mice, or to a lesser responsiveness of macrophages from P mice to activation by IFN-γ. Instead, P splenocytes produced 2- to 3-fold higher amounts of interleukin (IL)-4 and IL-10, which down-regulate the cytotoxic potential of IFN-γ-treated macrophages. Thus, the macrophage-activating potential of cytokine preparations from vaccinated P mice can be completely recovered by in vitro treatment with antibodies to IL-4 or IL-10. Lower levels of IL-12, which is involved in promoting development of Th1 responses, were produced by splenocytes from P as compared to C57BL/6 mice. The results indicate that a genetic predisposition toward impaired production of IL-12 and increased production of down-regulatory Th2 cytokines correlate with low response to vaccination against S. mansoni. KW - cercariae KW - cytokines KW - disease resistance KW - experimental infections KW - helminths KW - immune response KW - immunization KW - in vitro KW - interferon KW - interleukin 10 KW - interleukin 4 KW - irradiated vaccines KW - laboratory animals KW - macrophages KW - parasites KW - strains KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - resistance to disease KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803305&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human herpesvirus 8 (HHV-8) in the pathogenesis of Kaposi's sarcoma and other diseases. AU - Humphrey, R. W. AU - Davis, D. A. AU - Newcomb, F. M. AU - Yarchoan, R. JO - Leukemia and Lymphoma JF - Leukemia and Lymphoma Y1 - 1998/// VL - 28 IS - 3/4 SP - 255 EP - 264 SN - 1042-8194 AD - Humphrey, R. W.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004287. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Registry Number: 63585-09-1. N2 - The discovery of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV-8) and subsequent studies of this virus have provided a body of evidence that support the concept that this is an aetiologic agent for Kaposi's sarcoma (KS). Several studies have indicated that this virus may also be a causal agent for primary effusion lymphomas (PEL) and Castleman's disease. First generation serological assays for HHV-8 have now been developed. The preponderance of data suggest that the incidence of HHV-8 infection is highest in populations at risk for KS: male homosexuals, immunosuppressed patients, and those who live in endemic regions. HHV-8 encodes for functional homologues of human proteins that may play a role in the development of disease. As we learn more about the steps by which this virus can lead to KS and/or other diseases, rational therapies and preventative strategies may be possible. KW - acquired immune deficiency syndrome KW - antigens KW - B lymphocytes KW - cell lines KW - drugs KW - foscarnet sodium KW - homosexuality KW - human diseases KW - human immunodeficiency viruses KW - immunosuppression KW - infection KW - Kaposi's sarcoma KW - lymphoma KW - males KW - neoplasms KW - pathogenesis KW - pathogenicity KW - patients KW - phenotypes KW - populations KW - proteins KW - reviews KW - sarcoma KW - serology KW - surface antigens KW - surface proteins KW - Herpesviridae KW - human herpesvirus 8 KW - man KW - mice KW - viruses KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Rhadinovirus KW - Gammaherpesvirinae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - AIDS KW - antigenicity KW - B cells KW - cancers KW - homosexuals KW - human immunodeficiency virus KW - immunogens KW - Kaposi's sarcoma-associated herpesvirus KW - mechanisms KW - medicines KW - membrane proteins KW - pharmaceuticals KW - trisodium phosphonoformate KW - Pesticides and Drugs (General) (HH400) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004287&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National institutes of health (USA): role in tropical medicine research. AU - Western, K. A. JO - Southeast Asian Journal of Tropical Medicine and Public Health JF - Southeast Asian Journal of Tropical Medicine and Public Health Y1 - 1998/// VL - 29 IS - 2 SP - 316 EP - 318 SN - 0125-1562 AD - Western, K. A.: Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19992002721. Publication Type: Journal Article; Conference paper; Journal article. Language: English. KW - public health KW - research KW - tropical medicine KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Joint International Tropical Medicine Meeting KW - studies KW - United States of America KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002721&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Review of epidemiologic studies of alcohol and prostate cancer: 1971-1996. AU - Breslow, R. A. AU - Weed, D. L. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1998/// VL - 30 IS - 1 SP - 1 EP - 13 SN - 0163-5581 AD - Breslow, R. A.: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20001412662. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Human Nutrition N2 - Prostate cancer is the most common cancer among American men, with few established risk factors. The association between prostate cancer and alcohol, a potentially modifiable risk factor, has been examined in numerous studies. The literature on alcohol and the incidence of prostate cancer was reviewed by searching for published cohort and case-control studies using computerized databases, references, and experts, by evaluating studies for validity, and by summarizing the results and providing research recommendations. There was compelling evidence for no association between low-to-moderate alcohol consumption and prostate cancer. Most studies, however, did not assess the risk of heavy drinking, where there has been some suggestion of increased risk, or of lifetime patterns of drinking. None of the studies have used genetic markers, nor have they been conducted in populations with known familial risk. KW - alcoholic beverages KW - epidemiology KW - genetic factors KW - neoplasms KW - prostate KW - reviews KW - risk factors KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412662&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix. AU - Wideroff, L. AU - Potischman, N. AU - Glass, A. G. AU - Greer, C. E. AU - Manos, M. M. AU - Scott, D. R. AU - Burk, R. D. AU - Sherman, M. E. AU - Wacholder, S. AU - Schiffman, M. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1998/// VL - 30 IS - 2 SP - 130 EP - 136 SN - 0163-5581 AD - Wideroff, L.: Applied Research Branch, Division of Cancer Control and Population Science, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20001412968. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 50-81-7, 7235-40-7, 59-30-3, 68-26-8, 1406-18-4, 7440-66-6. Subject Subsets: Human Nutrition N2 - Several earlier case-control studies reported inverse associations of cervical squamous intraepithelial lesions (SIL) with high dietary or biomarker levels of carotenoids, folate, and vitamins C and E. However, most studies did not measure the primary causal factor, cancer-associated genital human papillomaviruses (HPV), now detected by sensitive viral DNA tests. This nested case-control study assessed whether high dietary intakes of these nutrients, plus zinc and vitamin A, reduced SIL risk in cancer-associated HPV DNA-positive women. Using a 60-item food-frequency questionnaire, nutrient estimates were obtained for 33 incident cases with high-grade lesions, 121 with low-grade lesions, 97 with equivocal SIL, and 806 cytologically normal controls sampled from a large prospective cohort study. Baseline cervicovaginal lavages were tested for HPV DNA by the polymerase chain reaction. Among DNA-positive cases (n=68) and controls (n=69), age-adjusted odds ratios (ORs) of SIL in the highest vs. the lowest nutrient quartiles were 1.4 [95% confidence interval (CI)=0.5-4.2] for vitamin A, 0.6 (CI=0.2-2.0) for β-carotene, 1.3 (CI=0.4-3.6) for vitamin C, 1.0 (CI=0.4-3.6) for vitamin E, 0.7 (CI=0.3-2.1) for folate, and 0.8 (CI=0.3-2.2) for zinc. ORs in HPV DNA-negative women approximated 1.0, with the exception of vitamin E (OR=0.5, CI=0.3-0.9). These results do not support a protective role for the above nutrients against low-grade or equivocal SIL, which constituted the majority of diagnoses in this study. KW - ascorbic acid KW - beta-carotene KW - carcinogenesis KW - carotenoids KW - cervical cancer KW - cervix KW - diets KW - epithelium KW - folic acid KW - intake KW - lesions KW - neoplasms KW - nutrients KW - questionnaires KW - ratios KW - retinol KW - surveys KW - vitamin E KW - vitamins KW - zinc KW - axerophthol KW - cancers KW - folacin KW - folate KW - tetraterpenoids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412968&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecules in focus. Leptin. AU - Prolo, P. AU - Wong MaLi AU - Licinio, J. JO - International Journal of Biochemistry & Cell Biology JF - International Journal of Biochemistry & Cell Biology Y1 - 1998/// VL - 30 IS - 12 SP - 1285 EP - 1290 AD - Prolo, P.: Unit on Clinical Research, Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA. N1 - Accession Number: 19991401060. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1, 169494-85-3. Subject Subsets: Human Nutrition N2 - A review. KW - body weight KW - hydrocortisone KW - leptin KW - obesity KW - reproduction KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cortisol KW - fatness KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401060&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish men. AU - Hartman, T. J. AU - Tangrea, J. A. AU - Pietinen, P. AU - Malila, N. AU - Virtanen, M. AU - Taylor, P. R. AU - Albanes, D. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1998/// VL - 31 IS - 1 SP - 41 EP - 48 CY - Mahwah; USA PB - Lawrence Erlbaum Associates Inc. SN - 0163-5581 AD - Hartman, T. J.: Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20003007116. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Public Health; Human Nutrition N2 - The association between coffee and black tea consumption and the subsequent risk of colon and rectal cancer was investigated within a Finnish clinical trial cohort. One hundred eleven cases of colon cancer and 83 cases of rectal cancer were diagnosed over a median of 8.0 years of follow-up. Proportional hazards regression models were used to derive adjusted relative risks (RR) and 95% confidence intervals (CI) for the association between coffee and tea consumption and cancer incidence. After controlling for confounders, coffee was not significantly associated with colon or rectal cancer. A positive association was seen for increased consumption of tea drinking and colon cancer. Compared with persons who did not drink tea, those who consumed <1 cup/day had an RR of 1.40 (95% CI=0.84-2.33) and those who consumed ≥1 cup/day had an RR of 2.09 (95% CI=1.34-3.26, p for trend=0.001). In contrast, tea consumption had little effect on rectal cancer incidence. This study does not support the hypothesis that coffee and tea protect against colorectal cancer risk. However, given the strength of the tea-colon cancer association and the significant gradient of risk we observed across level of intake, further epidemiologic research of this relationship in other populations seems warranted. KW - coffee KW - colon KW - consumption KW - human diseases KW - men KW - neoplasms KW - rectum KW - risk KW - tea KW - Finland KW - Camellia sinensis KW - Coffea KW - man KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Rubiaceae KW - Rubiales KW - Gentianales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003007116&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased retinol binding protein in the sera of patients with severe ischemic damage of the liver after transplantation. AU - Mastroianni, A. AU - Regalia, E. AU - Facchetti, G. AU - Longoni, P. D. AU - Formelli, F. AU - Pulvirenti, A. AU - Mazzaferro, V. JO - Clinical Biochemistry JF - Clinical Biochemistry Y1 - 1998/// VL - 31 IS - 2 SP - 113 EP - 116 SN - 0009-9120 AD - Mastroianni, A.: Division of Clinical Chemistry and Microbiology, Liver Transplantation Unit, National Cancer Institute, via Venezian 1, 20133 Milano, Italy. N1 - Accession Number: 19981411213. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Serum samples were obtained from 14 patients who had undergone orthotopic liver transplantation in Italy 2 weeks after the surgery and then once a month during the first year posttransplantation [date not given]. Retinol binding protein was measured in the samples by immunonephelometry. The patients were divided into 2 groups on the basis of early (first 10 days) postoperative graft function; group 1, 6 patients with severe ischaemic damage; and group II, 8 patients with moderate-severe liver dysfunction. The mean retinol binding protein concentration at one year of follow-up was persistently higher in group I than in group II (83.1±33.4 vs. 44.6±20.7 mg/litre, P<0.001). Retinol binding protein concentrations remained higher in patients of group I even when the other biochemical parameters of liver function returned to normal. The increase in retinol binding protein serum concentrations was independent of variation in other parameters of liver and kidney function, but was correlated with an increase in transthyretin and retinol concentrations. It is suggested that the results show a close relationship between a permanent high retinol binding protein concentration and severe graft injury after liver transplantation. KW - binding proteins KW - blood KW - liver KW - liver transplant KW - retinol KW - transplantation KW - transthyretin KW - vitamins KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - axerophthol KW - carrier proteins KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mammary gland carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets. AU - Snyderwine, E. G. AU - Thorgeirsson, U. P. AU - Meenakshi Venugopal AU - Roberts-Thomson, S. J. JO - Nutrition and Cancer JF - Nutrition and Cancer Y1 - 1998/// VL - 31 IS - 3 SP - 160 EP - 167 CY - Mahwah; USA PB - Lawrence Erlbaum Associates Inc. SN - 0163-5581 AD - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20003007239. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic amine derived from cooked meat. Mammary gland tumours were induced in female Sprague-Dawley rats given 10 doses of PhIP (75 mg/kg po) once per day from 43 days of age and then placed on a defined high-fat (23.5% corn [maize] oil) or low-fat (5% corn oil) diet for 25 weeks. Mammary tumour incidence was 49% (44 of 90 rats) and 31% (27 of 88 rats) in the high- and low-fat groups, respectively. No tumours were found in vehicle control rats on the high- or the low-fat diet (n=44 and 43, respectively). The higher tumour incidence in the high-fat group was due to an increase specifically in carcinomas (classified as tubulopapillary carcinomas) rather than benign tumours (tubular adenomas and fibroadenomas). The incidence of carcinomas was 45 and 24% in PhIP-treated rats on the high- and low-fat diets, respectively. In addition, the percentage of carcinomas showing stromal invasion was highest in the high-fat diet group (22 vs. 8%, high- vs. low-fat diet). Proliferating cell nuclear antigen immunostaining (PCNA) index revealed six times more proliferation in carcinomas from rats on the high-fat diet than in rats on the low-fat diet. Adenomas from rats on different diets had similar PCNA indexes. The tumour apoptotic index, quantitated by immunohistochemical detection (terminal deoxynucleotidyl transferase nick end labelling), was twice as high in carcinomas from rats on the high-fat diet as in carcinomas from rats on the low-fat diet but was similar between the two groups of adenomas. The PCNA-to-apoptosis ratio was 43 and 17 in carcinomas from rats on the high- and low-fat diets, respectively, indicating that the growth rate of carcinomas was greater in rats on the high-fat diet. The results from this study show that the high-fat diet increases the incidence, invasiveness, and growth of PhIP-induced mammary gland carcinomas. KW - animal models KW - breast cancer KW - diet KW - dietary fat KW - fats KW - heterocyclic nitrogen compounds KW - mammary glands KW - neoplasms KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - source fat KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003007239&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Non-Hodgkin's lymphoma and agricultural use of the insecticide lindane. AU - Blair, A. AU - Cantor, K. P. AU - Zahm, S. H. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1998/// VL - 33 IS - 1 SP - 82 EP - 87 SN - 0271-3586 AD - Blair, A.: Occupational Epidemiology Branch, National Cancer Institute, EPN Room 418, Bethesda, MD 20892-7364, USA. N1 - Accession Number: 19991100958. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4, 333-41-5, 608-73-1, 58-89-9. Subject Subsets: Agricultural Entomology N2 - Data from population-based case-control studies of non-Hodgkin's lymphoma among white men from Kansas, Nebraska, Iowa, and Minnesota were pooled to evaluate potential risks from environmental exposures, while controlling for potential confounding factors. These data provided the opportunity to evaluate the risk of non-Hodgkin's lymphoma from potential exposures to lindane. This pooled data set included 987 individuals with non-Hodgkin's lymphoma and 2895 population-based controls. Information was obtained by telephone or in person interviews, which included detailed questions on farm practices and agricultural use of chemicals. Reported use of lindane significantly increased the risk of non-Hodgkin's lymphoma by 50%. Some use characteristics were suggestive of an association. Odds ratios (ORs) were greater among persons who first used the pesticide 20 years before diagnosis (OR = 1.7) than more recently (OR = 1.3), among those who reported more frequent use (OR = 2.0 for use 5 or more days/year versus 1.6 for fewer than five days/year), and from use on crops (OR = 1.9), rather than from use on animals (OR = 1.3), although these differences were not statistically significant. On the other hand, ORs were lower when based on direct interviews (OR = 1.3) than on data from proxy respondents (OR = 2.1) and adjustment for potential confounding by use of 2,4-D and diazinon reduced the ORs associated with lindane use from 1.5 to 1.2 and 1.3, respectively. It is concluded that lindane does not appear to be a major aetiologic factor in the development of non-Hodgkin's lymphoma, although a small role cannot be ruled out. KW - 2,4-D KW - agricultural entomology KW - diazinon KW - HCH KW - insecticides KW - lindane KW - non-Hodgkin's lymphoma KW - nontarget effects KW - pesticides KW - Iowa KW - Kansas KW - Minnesota KW - Nebraska KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Great Plains States of USA KW - Northern Plains States of USA KW - Lake States of USA KW - (2,4-dichlorophenoxy)acetic acid KW - benzene hexachloride KW - BHC KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991100958&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. AU - Kaufman, H. L. AU - Roden, M. AU - Nathanson, D. AU - Basso, T. M. AU - Schwartzentruber, D. J. AU - Holland, S. M. JO - Journal of Pediatric Surgery JF - Journal of Pediatric Surgery Y1 - 1998/// VL - 33 IS - 5 SP - 761 EP - 763 SN - 0022-3468 AD - Kaufman, H. L.: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992000392. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9008-11-1. KW - bacterial diseases KW - case reports KW - children KW - clinical aspects KW - drug therapy KW - human diseases KW - interferon KW - leukopenia KW - mycobacterial diseases KW - splenectomy KW - splenomegaly KW - USA KW - man KW - Mycobacterium KW - Mycobacterium avium complex KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - chemotherapy KW - clinical picture KW - mycobacterial infections KW - panleukopenia KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000392&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - AIDS: a role for host genes. AU - O'Brien, S. J. JO - Hospital Practice JF - Hospital Practice Y1 - 1998/// VL - 33 IS - 7 SP - 53 EP - 79 SN - 0018-5809 AD - O'Brien, S. J.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA. N1 - Accession Number: 19982010941. Publication Type: Journal Article. Language: English. Number of References: 12 ref. N2 - Suspicion that human genes affect the natural history of AIDS has been confirmed by discoveries of three such genes, one of which confers near-total immunity in about 1% of Caucasians. The findings suggest a novel therapeutic target: not HIV but the host's cooperation with it. They also herald an era in which genomes are seen as having been shaped by the evolutionary pressures of infection, and may thus hold evolution-tested therapies. KW - acquired immune deficiency syndrome KW - genes KW - genomes KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - immunity KW - infection KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010941&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Construction of stable episomes in Cryptococcus neoformans. AU - Varma, A. AU - Kwon-Chung, K. J. JO - Current Genetics JF - Current Genetics Y1 - 1998/// VL - 34 IS - 1 SP - 60 EP - 66 SN - 0172-8083 AD - Varma, A.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991200124. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology N2 - The generation of stable plasmids constructed by inserting specific DNA sequences into previously known unstable vectors is reported. These sequences were obtained from a DNA library recovered from a previously reported stable minichromosome created by electroporative transformation in C. neoformans. A 6-kb insert from this minichromosome significantly enhanced both the frequencies at which URA5 transformants were obtained as well as the stability of their uracil prototrophy on non-selective media. A 1.5-kb sequence of this insert contained telomeric sequence repeats which when introduced into plasmids resulted in significant increases in transformation frequency. A 1081-bp sequence (STAB), present in the remainder of the insert, had an ARS-like function enhancing the episomal maintenance of plasmids in the transformants regardless of the gene (ADE2/URA5) used as a selection marker. KW - DNA KW - DNA libraries KW - genetics KW - nucleotide sequences KW - plasmid vectors KW - Cryptococcus neoformans KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - deoxyribonucleic acid KW - DNA sequences KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200124&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupational risk factors and prostate cancer in U.S. blacks and whites. AU - Krstev, S. AU - Baris, D. AU - Stewart, P. AU - Dosemeci, M. AU - Swanson, G. M. AU - Greenberg, R. S. AU - Schoenberg, J. B. AU - Schwartz, A. G. AU - Liff, J. M. AU - Hayes, R. B. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1998/// VL - 34 IS - 5 SP - 421 EP - 430 SN - 0271-3586 AD - Krstev, S.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. N1 - Accession Number: 19992007328. Publication Type: Journal Article. Language: English. Number of References: 50 ref. N2 - Occupational risk factors for prostate cancer were investigated in a large case control study among black and white subjects from the USA. The study included 981 new pathologically-confirmed prostate cancer cases (479 blacks and 502 whites) diagnosed during 1986-89, and 1315 population controls (594 blacks and 721 whites) who resided in Atlanta, Detroit, and 10 counties in New Jersey, covered by population-based cancer registries. Information on occupation, including a lifetime work history, was collected by in-person interview. No clear patterns of risk were found for U.S. whites versus blacks, nor for white-collar versus blue-collar jobs. Farming was related to prostate cancer (OR=2.17; 95% CI=1.18-3.98). Risk was restricted, however, to short-term workers and workers in crop production. Risk was not limited to those farming after 1950, when widespread use of pesticides started. Risks increased with increasing years of employment in firefighting (χ²trend, P=0.02) and power plant operations (χ²trend, P=0.03) and were elevated among long-term railroad line-haulers (OR=5.85; 95% CI=1.25-27.4); jobs with potential polycyclic aromatic hydrocarbon (PAH) exposures. Risk was elevated among athletes (OR=5.38; 95% CI=1.48-19.6). However, most of the cases were athletes before 1960, so the potential use of anabolic steroids was excluded. Although some clues about potential occupational associations were found, the overall results showed that occupation is not a major determinant of prostate cancer risk. KW - blacks KW - carcinoma KW - epidemiology KW - ethnic groups KW - human diseases KW - neoplasms KW - occupational health KW - prostate KW - risk factors KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007328&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Occupational risk factors for breast cancer among women in Shanghai. AU - Petralia, S. A. AU - Chow WongHo AU - McLaughlin, J. AU - Jin Fan AU - Gao YuTang AU - Dosemeci, M. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1998/// VL - 34 IS - 5 SP - 477 EP - 483 SN - 0271-3586 AD - Petralia, S. A.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19992007330. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - Data collected by the Shanghai Cancer Registry and the Chinese Third National Census were used to study the risk of breast cancer by occupation and by occupational exposures. Standardized incidence ratios (SIRs) were used to compare observed cases to expected numbers of cases, based on the incidence rates for Shanghai and the number of women in each occupation according to the 1982 census. Statistically elevated SIRs for breast cancer were seen for a number of professional occupational categories, with the greatest risk seen among scientific research workers (SIR=3.3). Administrative clerks, political and security personnel, and makers of rubber and plastics products also had significant excesses. Significant deficits of risk were seen for the categories of production and related workers, construction workers, and transportation equipment operators. For specific occupations, the highest SIRs were observed among doctors of Chinese-Western medicine (SIR=14.7, 95% CI=5.9-30.3) and doctors of Chinese medicine (SIR=7.2, 95% CI=4.4-11.4). Excesses were also found among teachers at each level of education, librarians, clerical workers, electrical and electronic engineers, nurses, lab technicians, accountants and book-keepers, rubber manufacturing products makers, weavers and knitters. SIRs were significantly elevated for high probability of exposure to organic solvents (SIR=1.4). For benzene exposure, significant excesses were found for overall exposure (SIR=1.1) and for medium level of exposure (SIR=1.3). There was no evidence of an association between risk and electromagnetic fields (EMF) exposure. Based on a small number of exposed, SIRs were elevated for both medium probability and high level of exposure to pesticides. KW - breast cancer KW - chemicals KW - epidemiology KW - exposure KW - human diseases KW - neoplasms KW - occupational health KW - pesticides KW - risk factors KW - women KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007330&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exposure opportunities of families of farmer pesticide applicators. AU - Gladen, B. C. AU - Sandler, D. P. AU - Zahm, S. H. AU - Kamel, F. AU - Rowland, A. S. AU - Alavanja, M. C. R. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1998/// VL - 34 IS - 6 SP - 581 EP - 587 SN - 0271-3586 AD - Gladen, B. C.: Biostatistics Branch, Mail Drop A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19992008130. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - Subjects were 26 793 licensed private pesticide applicators enrolled in the Agricultural Health Study, a cohort study being conducted in Iowa and North Carolina, USA. Questionnaires were completed by the applicators and their spouses. Many indirect exposure opportunities exist; for example, 21% of homes are within 50 yards of pesticide mixing areas, 27% of applicators store pesticides in their homes, and 94% of clothing worn for pesticide work is washed in the same machine as other laundry. Direct exposure opportunities also occur; for example, 51% of wives of applicators worked in the fields in the last growing season, 40% of wives have ever mixed or applied pesticides, and over half of children aged 11 or more do farm chores. It is concluded that the extent of the opportunities for exposure of family members of farmer pesticide applicators makes studies of their health important. KW - agriculture KW - children KW - clothing KW - exposure KW - families KW - farmers KW - homes KW - pesticides KW - spraymen KW - Iowa KW - North Carolina KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Appalachian States of USA KW - Southern States of USA KW - South Atlantic States of USA KW - apparel KW - clothes KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008130&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Megestrol acetate for anorexia in patients with far-advanced cancer: a double-blind controlled clinical trial. AU - Conno, F. de AU - Martini, C. AU - Zecca, E. AU - Balzarini, A. AU - Venturino, P. AU - Groff, L. AU - Caraceni, A. JO - European Journal of Cancer JF - European Journal of Cancer Y1 - 1998/// VL - 34 IS - 11 SP - 1705 EP - 1709 SN - 0959-8049 AD - Conno, F. de: Pain Therapy, Rehabilitation and Palliative Care Division, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy. N1 - Accession Number: 19981417446. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 3562-63-8, 595-33-5. Subject Subsets: Human Nutrition N2 - The effects of a low-dose regimen of megestrol acetate (MA; 320 mg/day) on appetite in advanced cancer patients in Italy were evaluated. Out-patients with far-advanced non-hormone responsive tumours and loss of appetite were randomized in a phase III trial, with 2 consecutive phases: a 14-day double-blind placebo controlled phase (phase A) and a 76-day open phase (phase B). During phase A, patients were treated with MA, two 160 mg tablets/day, or placebo. In phase B, the MA dose was titrated to clinical response in both groups. Appetite, food intake, body weight, performance status, mood and quality of life were evaluated with standardized measures; patients' global judgement about treatment efficacy was also requested. Of 42 patients entering the study, 33 (17 MA and 16 placebo) were evaluable for efficacy. The appetite score improved significantly with MA after 7 days (P=0.0023), and this effect was still significant at 14 days (P=0.0064). Patients judged the treatment with MA effective in 88.2% of cases (14th day), whilst placebo was considered effective by 25% (P=0.0003). None of the other measures showed significant changes during treatment. The remarkable effect on appetite evident after 7 days, without serious side-effects, shows that MA can produce significant subjective effects at a low-dose even in patients with far-advanced disease. KW - anorexia KW - appetite KW - body weight KW - drug therapy KW - food intake KW - megestrol KW - neoplasms KW - quality of life KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - cancers KW - chemotherapy KW - inappetence KW - megestrol acetate KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417446&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Correlation between human papillomavirus DNA detection in maternal cervical smears and buccal swabs of infants. AU - Chatterjee, R. AU - Mukhopadhyay, D. AU - Murmu, N. AU - Mitra, P. K. JO - Indian Journal of Experimental Biology JF - Indian Journal of Experimental Biology Y1 - 1998/// VL - 36 IS - 2 SP - 199 EP - 202 SN - 0019-5189 AD - Chatterjee, R.: Department of Tumor Virology, Chittarajan National Cancer Institute, 37 S P Mukherjee Road, Calcutta 700 026, India. N1 - Accession Number: 19982007517. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9007-49-2. Subject Subsets: Tropical Diseases N2 - The presence of human papillomavirus (HPV) in exfoliated cervical cells of pregnant women was evaluated, and the pattern of HPV transmission from Indian mothers to their neonates at birth was studied. Cervical smear cells were collected about 24 h before childbirth from 30 unselected pregnant women. Buccal swabs were collected 24 h after birth from the corresponding 31 infants (1 set of twins). The study was limited to HPV types 6/11, 16/18 and 31/33/35. HPV DNA was detected among 40% of the women (n=12), and HPV DNA was transmitted into the oral cavities of 5 (41.6%) infants from the 12 HPV-positive mothers. Maternal-infant transmission was highest for HPV 6/11 (66.6%), whereas HPV 16/18 occurred in 20% of the total cases. KW - cervix KW - DNA KW - human diseases KW - infants KW - maternal transmission KW - neonates KW - pregnancy KW - viral diseases KW - India KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - Papillomaviridae KW - deoxyribonucleic acid KW - gestation KW - human papillomavirus KW - mother to child transmission KW - newborn infants KW - Papovaviridae KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Concentrations of airborne Aspergillus compared to the incidence of invasive aspergillosis: lack of correlation. AU - Hospenthal, D. R. AU - Kwon-Chung, K. J. AU - Bennett, J. E. JO - Medical Mycology JF - Medical Mycology Y1 - 1998/// VL - 36 IS - 3 SP - 165 EP - 168 AD - Hospenthal, D. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202086. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Air sampling of the rooms and corridors of the oncology wards of the National Institutes of Health Clinical Center, Bethesda, MD, USA, was carried out during a 54-week period (autumn 1974-autumn 1975) to assess the concentration of viable Aspergillus conidia. A. fumigatus and A. flavus were recovered at a mean of 1.83 cfu/m³ air sampled. Individual samplings yielded concentrations of up to 11.6 cfu/m³. Other Aspergillus spp. were recovered at a mean of 2.38 cfu/m³ (maximum 32.6 cfu/m³). Concentration was not correlated with season or hospital ward. Review of postmortem examination results showed a mean of 6.6 cases of aspergillosis annually over a 22-year period (1956-77). No seasonal variation in case incidence was found. Six cases of invasive aspergillosis were diagnosed on the 3 cancer wards during the air sampling period, but no association was seen linking these cases with changes in recovery of airborne Aspergillus. A seasonal pattern was not observed in the overall incidence of aspergillosis cases nor concentrations of airborne conidia. KW - air KW - aspergillosis KW - contamination KW - disease transmission KW - epidemiology KW - hospitals KW - human diseases KW - nosocomial infections KW - Maryland KW - USA KW - Aspergillus KW - Aspergillus flavus KW - Aspergillus fumigatus KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fungus KW - hospital infections KW - Hyphomycetes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202086&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings. AU - Sinha, R. AU - Rothman, N. AU - Salmon, C. P. AU - Knize, M. G. AU - Brown, E. D. AU - Swanson, C. A. AU - Rhodes, D. AU - Rossi, S. AU - Felton, J. S. AU - Levander, O. A. JO - Food and Chemical Toxicology JF - Food and Chemical Toxicology Y1 - 1998/// VL - 36 IS - 4 SP - 279 EP - 287 SN - 0278-6915 AD - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza North, Rm 430, 6130 Executive Blvd, Rockville, MD 20892, USA. N1 - Accession Number: 19981411274. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - Heterocyclic amines (HCA) ([2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP)]) were determined in cooked beef using solid-phase extraction and HPLC. Steak and hamburger patties were pan-fried, oven-broiled and grilled/barbecued to 4 levels of doneness (rare, medium, well done or very well done), while beef roasts were oven cooked to 3 levels of doneness (rare, medium or well done). HCA varied with the cut of beef, cooking method and doneness level. In general, MeIQx content increased with doneness under each cooking condition for steak and hamburger patties, up to 8.2 ng/g. PhIP was the predominant HCA produced in steak (1.9-30.0 ng/g), but was formed only in very well done fried or grilled hamburger. DiMeIQx was found in trace levels in pan-fried steaks only, while IQ and MeIQ were not detectable in any of the samples. Roast beef did not contain any of the HCA, but the gravy made from the drippings from well done roasts had 2 and 7 ng/g of PhIP and MeIQx, respectively. It is concluded that epidemiological studies need to consider the type of meat, cooking method and degree of doneness/surface browning in survey questions to adequately assess the exposure of an individual to HCA. KW - amines KW - beef KW - composition KW - cooking KW - frying KW - heterocyclic nitrogen compounds KW - meat cuts KW - meat products KW - roasting KW - steaks KW - Meat Produce (QQ030) KW - Food Composition and Quality (QQ500) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411274&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Spinal extradural cysticercosis: a case report. AU - Mohanty, A. AU - Das, S. AU - Kolluri, V. R. S. AU - Das, B. S. JO - Spinal Cord JF - Spinal Cord Y1 - 1998/// VL - 36 IS - 4 SP - 285 EP - 287 AD - Mohanty, A.: Department of Neurosurgery, National Institute of Mental Health & Neuro Sciences, Bangalore, India. N1 - Accession Number: 19990800167. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 54965-21-8. Subject Subsets: Helminthology; Tropical Diseases N2 - A rare case of extradural spinal cysticercosis (caused by Taenia solium) in a 55-year-old man from India is presented. The patient presented with paraesthesiae and progressive weakness in all limbs of 5 months duration. He had evidence of extradural granulation tissue with associated destruction of C4 and C5 pedicles and laminae, causing tetraparesis. Histopathological examination revealed evidence of a degenerated cysticercal cyst with host tissue reaction. The patient showed a gradual and marked improvement after surgical decompression and a 4-week course of 15 mg/kg albendazole supplemented with corticoids for the first 2 weeks. Although rare, cysticercosis as a possible aetiology of extradural spinal compression in endemic areas. KW - aetiology KW - albendazole KW - anthelmintics KW - case reports KW - cestode infections KW - cestode larvae KW - clinical aspects KW - corticoids KW - cysticercosis KW - drug therapy KW - helminths KW - histopathology KW - human diseases KW - metacestodes KW - parasites KW - pathology KW - spine KW - surgery KW - treatment KW - India KW - man KW - Taenia solium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - causal agents KW - chemotherapy KW - clinical picture KW - corticosteroids KW - etiology KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990800167&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness. AU - Sinha, R. AU - Knize, M. G. AU - Salmon, C. P. AU - Brown, E. D. AU - Rhodes, D. AU - Felton, J. S. AU - Levander, O. A. AU - Rothman, N. JO - Food and Chemical Toxicology JF - Food and Chemical Toxicology Y1 - 1998/// VL - 36 IS - 4 SP - 289 EP - 297 SN - 0278-6915 AD - Sinha, R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza North, Rm 430, 6130 Executive Blvd, Rockville, MD 20892, USA. N1 - Accession Number: 19981411275. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition; Pig Science N2 - The concentrations of the heterocyclic amines (HCA) 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were measured in pork chops, ham slices, bacon and pork sausages cooked by different techniques and to varying levels of doneness. Pork chops and ham slices were pan-fried and oven-broiled; bacon was pan-fried, oven-broiled or microwaved; hot dogs were pan-fried, oven-broiled, grilled/barbecued or boiled; sausages and patties were pan-fried. All the products were cooked until just done, well done or very well done. HCA type and level varied by pork product, cooking method and doneness level. The highest PhIP levels were found in well done and very well done oven-broiled bacon; for very well done 30.3 and 4.0 ng/g of meat of PhIP and MeIQx, respectively. Pan-fried very well done sausage patties contained 5.4 ng/g MeIQx, while sausages contained 1.3 ng/g. MeIQx was formed in well done and very well done pan-fried but not broiled pork chops. Hot dogs or ham slices had low or undetectable levels of HCA. It is concluded that epidemiological studies investigating the relationship between HCA intake and cancer risk need to incorporate type of meat, cooking method and degree of doneness/surface browning into questions to adequately assess the exposure of an individual to HCA. KW - amines KW - bacon KW - cooking KW - frying KW - ham KW - heterocyclic nitrogen compounds KW - meat KW - meat products KW - methodology KW - neoplasms KW - pigmeat KW - sausages KW - cancers KW - methods KW - pork KW - Meat Produce (QQ030) KW - Food Composition and Quality (QQ500) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411275&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats. AU - Kusamran, W. R. AU - Ratanavila, A. AU - Tepsuwan, A. JO - Food and Chemical Toxicology JF - Food and Chemical Toxicology Y1 - 1998/// VL - 36 IS - 6 SP - 475 EP - 484 SN - 0278-6915 AD - Kusamran, W. R.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Bangkok, Thailand. N1 - Accession Number: 19981414122. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9035-51-2, 70-18-8, 50812-37-8. Subject Subsets: Horticultural Science; Human Nutrition; Agroforestry N2 - The effects of feeding of neem tree flowers (Azadirachta indica var. siamtensis), fruits of Thai and Chinese bitter gourd (Momordica charantia) and leaves of sweet basil (Ocimum basilicum) on the levels of phase I enzymes, (cytochrome P450 (P450), aniline hydroxylase (ANH) and aminopyrine-N-demethylase (AMD)), the capacity to activate the mutagenic potential of aflatoxin B1 (AFB1) and benzo[α]pyrene (BaP), and to induce the phase II enzymes (i.e. glutathione S-transferase (GST)) was studied in the livers of 20 rats. Feeding diets containing 12.5% neem flowers and Thai bitter gourd fruits for 2 weeks increased GST activity, 2.7- and 1.6-fold compared with pair-fed control values, respectively. There was a marked reduction of phase I enzyme activity. Fruits of the Chinese bitter gourd, had no effect on GST activity but decreased AMD activity and the in vitro metabolic activation of AFB1 and BaP. Dietary sweet basil leaves caused a significant increase in GST and all phase I enzymes. Neem flowers and Thai bitter gourd fruits contain monofunctional phase II enzyme inducers and compounds capable of repressing some monooxygenases, especially those involved in the metabolic activation of chemical carcinogens, while sweet basil leaves contain compounds, probably bifunctional inducers, capable of inducing phase I and phase II enzymes and Chinese bitter gourd fruits contain only compounds capable of repressing some monooxygenases. It is concluded that neem flowers and Thai bitter gourd fruits may possess chemopreventive potential, the potential of Chinese bitter gourd fruits and sweet basil leaves are not yet defined. KW - aflatoxins KW - carcinogens KW - cytochrome P-450 KW - enzyme activity KW - enzymes KW - glutathione KW - glutathione transferase KW - hepatotoxins KW - in vitro KW - inhibition KW - leaves KW - medicinal properties KW - multipurpose trees KW - mycotoxins KW - trees KW - woody plants KW - Thailand KW - Azadirachta KW - Azadirachta indica KW - Momordica KW - Momordica charantia KW - Ocimum basilicum KW - plants KW - rats KW - Meliaceae KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Azadirachta KW - Cucurbitaceae KW - Violales KW - Momordica KW - Ocimum KW - Lamiaceae KW - Lamiales KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - aminopyrine N-demethylase KW - aniline hydroxylase KW - fungal toxins KW - ligandin KW - neem KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Crop Produce (QQ050) KW - Non-wood Forest Products (KK540) KW - Agroforestry and Multipurpose Trees; Community, Farm and Social Forestry (KK600) KW - Non-food/Non-feed Plant Products (SS200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414122&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rapid extraction of genomic DNA from medically important yeasts and filamentous fungi by high-speed cell disruption. AU - Müller, F. M. C. AU - Werner, K. E. AU - Kasai, M. AU - Francesconi, A. AU - Chanock, S. J. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1998/// VL - 36 IS - 6 SP - 1625 EP - 1629 SN - 0095-1137 AD - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201781. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology N2 - A rapid DNA isolation method using high-speed cell disruption (HSCD) incorporating chaotropic reagents and lysing matrices was studied in comparison with standard phenol-chloroform (PC) extraction protocols for isolation of DNA from Candida albicans, Cryptococcus neoformans, Trichosporon beigelii, Aspergillus fumigatus and Fusarium solani. Additional extractions by HSCD were performed on Saccharomyces cerevisiae, Pseudallescheria boydii and Rhizopus arrhizus. Two different inocula (108 and 107 colony forming units (CFU)) were compared for optimization of obtained yields. The entire extraction procedure was performed on as many as 12 samples within 1 h compared with 6 h for PC extraction. In comparison with the PC procedure, HSCD DNA extraction demonstrated significantly greater yields for 108 CFU of C. albicans, T. beigelii, A. fumigatus and F. solani (P≤0.005), 107 CFU of C. neoformans (P≤0.05) and 107 CFU of A. fumigatus (P≤0.01). Yields were within the same range for 108 CFU of C. neoformans and 107 CFU of C. albicans for both HSCD extraction and PC extraction. For 107 CFU of T. beigelii, PC extraction resulted in a greater yield than did HSCD (P≤0.05). Yields obtained from 108 and 107 CFU were significantly greater for filamentous fungi than for yeasts by the HSCD extraction procedure (P<0.0001). By the PC extraction procedure, differences were not significant. For all 8 organisms, the rapid extraction procedure resulted in good yield, integrity and quality of DNA as demonstrated by restriction fragment length polymorphism, PCR and random amplified polymorphic DNA. It is concluded that mechanical disruption of fungal cells by HSCD is a safe, rapid and efficient procedure for extracting genomic DNA from medically important yeasts and especially from filamentous fungi. KW - DNA KW - extraction KW - methodology KW - techniques KW - Aspergillus fumigatus KW - Candida albicans KW - Cryptococcus neoformans KW - Haematonectria haematococca KW - Pseudallescheria boydii KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Trichosporon beigelii KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Fusarium KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Saccharomyces KW - Saccharomycetaceae KW - Trichosporon KW - Trichosporonaceae KW - Haematonectria KW - deoxyribonucleic acid KW - fungus KW - Fusarium solani KW - Hyphomycetes KW - methods KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201781&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Invasive infection with Fusarium chlamydosporum in a patient with aplastic anemia. AU - Segal, B. H. AU - Walsh, T. J. AU - Liu, J. M. AU - Wilson, J. D. AU - Kwon-Chung, K. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1998/// VL - 36 IS - 6 SP - 1772 EP - 1776 SN - 0095-1137 AD - Segal, B. H.: Laboratory of Host Defenses, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201784. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - A case is reported in a 40-year-old woman from Maryland, USA [date not given], with aplastic anaemia, who developed persistent fever and a raised, dark, crusted lesion on the left middle nasal turbinate while receiving immunosuppressive therapy and empirical amphotericin B (0.5 mg/kg daily). The lesion was surgically excised and histological analysis demonstrated invasive hyaline hyphae and some darkly pigmented structures that resembled conidia of dematiaceous molds. The dosage of amphotericin B was increased to 1.0 mg/kg daily and then changed to amphotericin B lipid complex (5 mg/kg daily) due to progressive azotaemia. Sputum culture grew F. chlamydosporum shortly after excision of the lesion. No bone involvement of evidence of progression of the disease was detected over the next few weeks; the patient died of multi-organ failure after undergoing a bone marrow transplantation, with no evidence of residual fusariosis. KW - amphotericin B KW - aplastic anaemia KW - case reports KW - drug formulations KW - fusariosis KW - human diseases KW - immunocompromised hosts KW - infections KW - lipids KW - mycoses KW - opportunistic infections KW - predisposition KW - women KW - Maryland KW - USA KW - Fusarium chlamydosporum KW - man KW - Fusarium KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aplastic anemia KW - fungus KW - fusarioses KW - Hyphomycetes KW - lipins KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201784&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC) and bioassay of mammary gland carcinogenicity in Sprague-Dawley rats. AU - Snyderwine, E. G. AU - Sadrieh, N. AU - King, R. S. AU - Schut, H. A. J. JO - Food and Chemical Toxicology JF - Food and Chemical Toxicology Y1 - 1998/// VL - 36 IS - 12 SP - 1033 EP - 1041 SN - 0278-6915 AD - Snyderwine, E. G.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Building 37, Room 3C28, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19990401871. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - Mammary gland carcinogenicity of 2-amino-9H-pyrido[2,3-b]indole (AαC), a heterocyclic amine found at relatively high concentrations in barbecued or grilled meats, was studied in female Sprague-Dawley rats. The rats were given 10 oral doses of 75 mg AαC from 43 days of age (2 consecutive 5-day periods separated by 2 days) and then placed on a high-fat (23.5% maize oil) diet for up to 50 weeks. By the end of the study period, only 1 of 20 rats had developed a mammary tumour, which was diagnosed histologically as a tubulopapillary carcinoma. No tumour development was found in other major organs. In DNA-adduct studies on rats that were necropsied 3 h after a single or multiple oral doses of 75 mg AαC/kg in maize oil, the total AαC-DNA adduct levels were much higher in liver than in other tissues. One major AαC-DNA adduct was found in mammary gland epithelial cells and other extra-hepatic tissues after single or multiple dosing, and up to 3 minor adducts were also found after multiple dosing. It is suggested that the weak mammary carcinogenicity of AαC may in part be associated with low AαC-DNA adduct levels in mammary gland epithelium. KW - amines KW - animal models KW - biogenic amines KW - breast cancer KW - carcinogenesis KW - carcinogens KW - epithelium KW - indoles KW - mammary gland neoplasms KW - mammary glands KW - meat products KW - neoplasms KW - man KW - rats KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - cancers KW - mammary tumour KW - General Physiology (ZZ340) (Discontinued March 2000) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Animal Models of Human Nutrition (VV140) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990401871&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fate of transforming DNA in pathogenic fungi. AU - Kwon-Chung, K. J. AU - Goldman, W. E. AU - Klein, B. AU - Szaniszlo, P. J. A2 - Polonelli, L. O. A2 - Walsh, T. J. JO - Medical Mycology JF - Medical Mycology Y1 - 1998/// VL - 36 IS - Suppl. 1 SP - 38 EP - 44 AD - Kwon-Chung, K. J.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202943. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. KW - DNA KW - genetic transformation KW - molecular genetics KW - Blastomyces dermatitidis KW - Cryptococcus neoformans KW - Exophiala dermatitidis KW - fungi KW - Histoplasma capsulatum KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Blastomyces KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Herpotrichiellaceae KW - Chaetothyriales KW - Exophiala KW - Ajellomyces capsulatus KW - biochemical genetics KW - deoxyribonucleic acid KW - fungus KW - Wangiella KW - Wangiella dermatitidis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202943&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of vaccines and their use in the prevention of fungal infections. AU - Dixon, D. M. AU - Casadevall, A. AU - Klein, B. AU - Mendoza, L. AU - Travassos, L. AU - Deepe, G. S., Jr. A2 - Polonelli, L. O. A2 - Walsh, T. J. JO - Medical Mycology JF - Medical Mycology Y1 - 1998/// VL - 36 IS - Suppl. 1 SP - 57 EP - 67 AD - Dixon, D. M.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202946. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 90 ref. KW - blastomycosis KW - cryptococcosis KW - disease prevention KW - histoplasmosis KW - human diseases KW - immunization KW - mycoses KW - paracoccidioidomycosis KW - reviews KW - vaccination KW - Blastomyces dermatitidis KW - Cryptococcus neoformans KW - Histoplasma capsulatum KW - man KW - Paracoccidioides brasiliensis KW - Pythiaceae KW - Pythium KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Blastomyces KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Paracoccidioides KW - Pythiaceae KW - Pythiales KW - Oomycetes KW - Oomycota KW - Mastigomycotina KW - Ajellomyces capsulatus KW - european blastomycosis KW - fungus KW - immune sensitization KW - Peronosporomycetes KW - pythiosis KW - south american blastomycosis KW - Straminipila KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202946&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. AU - Lee, C. G. L. AU - Gottesman, M. M. AU - Cardarelli, C. O. AU - Ramachandra, M. AU - Jeang KuanTeh AU - Ambudkar, S. V. AU - Pastan, I. AU - Dey, S. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1998/// VL - 37 IS - 11 SP - 3594 EP - 3601 SN - 0006-2960 AD - Lee, C. G. L.: Laboratory of Cell Biology, Bldg 37, Rm 1A09, National Cancer Institute, HIH, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982007316. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - The purpose of this study was to determine whether the protease inhibitors ritonavir, saquinavir, and indinavir are recognized by the MDR 1 multidrug transporter (P-glycoprotein, or P-gp), thereby reducing their intracellular accumulation. The results of this study indicate that the HIV-1 protease inhibitors are substrates of the human multidrug transporter, suggesting that cells in patients that express the MDR 1 transporter will be relatively resistant to the antiviral effects of the HIV-1 protease inhibitors, and that absorption, excretion, and distribution of these inhibitors in the body may be affected by the multidrug transporter. KW - antiviral agents KW - drug resistance KW - glycoproteins KW - human diseases KW - inhibitors KW - proteinase inhibitors KW - proteinases KW - substrates KW - treatment KW - uptake KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - P-glycoprotein KW - protease inhibitors KW - proteases KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Risk factors and outcome of non-Candida spp. yeasts causing fungaemia in cancer patients: comparison with Candida albicans. AU - Krčméry, V., Jr. AU - Kunová, A. AU - Trupl, J. T2 - Journal of Hospital Infection JO - Journal of Hospital Infection JF - Journal of Hospital Infection Y1 - 1998/// VL - 38 IS - 2 SP - 151 EP - 154 SN - 0195-6701 AD - Krčméry, V., Jr.: Department of Medicine, National Cancer Institute, University of Trnava, School of Public Health, 812 50 Bratislava, Slovakia. N1 - Accession Number: 19981201427. Publication Type: Correspondence. Language: English. Number of References: 3 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Cases (n=12) of non-Candida yeast fungaemia seen during the last 7 years at the National Cancer Institute, Bratislava, Slovakia, are reported. When azole prophylaxis was started in 1992, only 1 case of non-Candida fungaemia (due to Blastoschizomyces capitatus) was observed within 3 years, the remaining 11 cases appeared within the last 4 years. Six fungaemias were caused by Trichosporon spp., 3 by Cryptococcus laurentii, 1 by Hansenula anomala and 1 by Rhodotorula rubra. Six patients survived and 5 died of fungaemia. The risk factors for the 12 cases included neutropenia, previous antibiotic therapy, prophylaxis with quinolones, infected catheter, acute leukaemia, mucositis and multiple positive blood cultures for yeasts. Comparing 2 groups of fungaemias (non-Candida vs. C. albicans) occurring in the same period at the institute, multiple positive cultures, acute leukaemia, prophylaxis with ofloxacin, prophylaxis with itraconazole and infected catheter were significantly associated with non-Candida spp. aetiology in comparison with 43 C. albicans fungaemias. However, incidence of complications, overall and attributable mortality were similar in both groups. KW - blood KW - epidemiology KW - fungaemia KW - human diseases KW - immunocompromised hosts KW - infections KW - neoplasms KW - opportunistic infections KW - predisposition KW - risk factors KW - Slovakia KW - Candida albicans KW - Cryptococcus laurentii KW - man KW - Pichia anomala KW - Rhodotorula mucilaginosa KW - Saccharomycetaceae KW - Trichosporon KW - Trichosporon capitatum KW - Blastoschizomyces KW - Dipodascaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Hansenula KW - Pichiaceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Rhodotorula KW - Sporidiobolales KW - Microbotryomycetes KW - Pucciniomycotina KW - Trichosporonaceae KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Trichosporon KW - Pichia KW - Blastoschizomyces capitatus KW - cancers KW - fungemia KW - fungus KW - Hansenula anomala KW - Hyphomycetes KW - Rhodotorula rubra KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201427&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cartesian coordinate analysis of viral burden and CD4+ T-cell count in human immunodeficiency virus type-1 infection. AU - Reichelderfer, P. S. AU - Coombs, R. W. JO - Antiviral Research JF - Antiviral Research Y1 - 1998/// VL - 38 IS - 3 SP - 181 EP - 194 SN - 0166-3542 AD - Reichelderfer, P. S.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982012343. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 63231-63-0. N2 - A Cartesian coordinate plot was used to analyse the inverse relationship between viral burden (x-axis) and peripheral blood CD4+ cell count (y-axis) to extend our understanding of the mechanisms of antiviral drugs and differences in outcome resulting from variability in virus and host responses. Each of 186 subjects studied were assigned to one of four response quadrants. Quadrants A (x -, y +) and D (x +, y -) defined the effect of a change in virus load on the inverse change in CD4+ cell count expected from the natural history of HIV infection or antiretroviral therapy. Quadrants B (x +, y +) and C (x -, y -) defined the dissociation of the inverse relationship between the relative changes in CD4+ cell count and viral load that resulted from the hypothesized effect of putative virological or immunological response modifiers. Of the response modifiers studied, only the syncytium-inducing phenotype resulted in a complete dissociation of this inverse relationship. The analysis provided an integrated virological and immunological approach to better understand therapeutic responses and potential dissociation between changes in viral RNA and CD4 + cell count. This type of analysis may be helpful for individualizing patient management as well as designing and analysing studies of HIV-1 antiretroviral drugs and disease pathogenesis. KW - antiviral agents KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - leukocyte count KW - pathogenesis KW - phenotypes KW - relationships KW - RNA KW - T lymphocytes KW - variation KW - viral load KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cell count KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - T cells KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012343&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - N-3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products. AU - Zhang HongJian AU - Hamilton, J. H. AU - Salem, N., Jr. AU - Kim HeeYong JO - Journal of Lipid Research JF - Journal of Lipid Research Y1 - 1998/// VL - 39 IS - 7 SP - 1397 EP - 1403 SN - 0022-2275 AD - Zhang HongJian: Section of Mass Spectrometry, National Institutes of Health, Rockville, MD 20852, USA. N1 - Accession Number: 19981413086. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 506-32-1, 9029-60-1, 73-31-4. Subject Subsets: Human Nutrition N2 - In pineal glands from n-3 fatty acid-deficient Sprague-Dawley rats, an 87% reduction of docosahexaenoic acid was observed, and this decrease was accompanied by increases in docosatetraenoic acid (3-fold), docosapentaenoic acid (12-fold) and arachidonic acid (48%). The significant decrease of docosahexaenoic acid containing species in phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS) was also evident. These decreases in docosahexaenoic acid containing phospholipid species were compensated by substantial accumulations of docosatetraenoic acid or docosapentaenoic acid and slight increases in arachidonic acid containing PL species in PC and PE. In PS, however, the accumulation of n-6 species was not adequate to compensate for the loss of docosahexaenoic acid species. n-3 fatty acid deficiency significantly reduced non-esterified arachidonic acid and docosahexaenoic acid levels in pineal glands (25% and 65%, respectively). Concomitantly, the endogenous 12-HETE level decreased by 35% in deficient pineal glands. In contrast, n-3 deficiency led to a more than 60% increase in the daytime pineal gland melatonin level. It is concluded that n-3 fatty acid deficiency not only has profound effects on pineal gland lipid profiles but also on pineal glandbiochemical activities. This suggests that n-3 fatty acids may play a critical role in regulating pineal gland function. KW - arachidonic acid KW - composition KW - deficiency KW - lipoxygenase KW - melatonin KW - metabolism KW - phospholipids KW - pineal body KW - polyenoic fatty acids KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - eicosatetraenoic acid KW - polyunsaturated fatty acids KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981413086&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent trends in tropical medicine research at NIAID/NIH (USA). AU - Western, K. A. JO - Tropical Medicine (Nagasaki) JF - Tropical Medicine (Nagasaki) Y1 - 1998/// VL - 40 IS - 4 SP - 196 EP - 197 SN - 0385-5643 AD - Western, K. A.: National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), USA. N1 - Accession Number: 19992010009. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Tropical Diseases N2 - This summarized conference paper briefly identifies major challenges facing tropical medicine and discusses general strategies which the National Institute of Allergy and Infectious Disease (NIAID) is developing to meet these challenges. KW - disease control KW - human diseases KW - medicine KW - tropical diseases KW - tropical medicine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - medical sciences KW - NIAID KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Agencies and Organizations (DD100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010009&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins. AU - Huang, M. AU - Maynard, A. AU - Turpin, J. A. AU - Graham, L. AU - Janini, G. AU - Covell, D. G. AU - Rice, W. G. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1998/// VL - 41 IS - 9 SP - 1371 EP - 1381 SN - 0022-2623 AD - Huang, M.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 431T-B, P.O. Box B Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982007246. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Registry Number: 9007-49-2, 7440-66-6. N2 - Agents that target the two highly conserved Zn fingers of HIV nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native protein structure and nucleic acid binding capacity, and disruption of virus replication. Concentrations of 3 antiviral agents that promoted in vitro Zn ejection from NCp7 and inhibited HIV replication did not impact on the functions of cellular Zn finger proteins, including poly(ADP-ribose) polymerase and Sp1 and GATA-1 transcription factors, nor did the compounds inhibit HeLa nuclear extract-mediated transcription. KW - antiviral agents KW - binding KW - coat proteins KW - DNA KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - nucleic acids KW - proteins KW - replication KW - structure KW - transcription KW - transcription factors KW - viral replication KW - zinc KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - capsid proteins KW - deoxyribonucleic acid KW - DNA transcription KW - human immunodeficiency virus KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007246&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Maternal diabetes status does not influence energy expenditure or physical activity in 5-year-old Pima Indian children. AU - Salbe, A. D. AU - Fontvieille, A. M. AU - Pettitt, D. J. AU - Ravussin, E. JO - Diabetologia JF - Diabetologia Y1 - 1998/// VL - 41 IS - 10 SP - 1157 EP - 1162 SN - 0012-186X AD - Salbe, A. D.: Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. N1 - Accession Number: 19991407198. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - The study examined whether maternal diabetes status influences total energy expenditure (TEE by doubly labelled water), resting metabolic rate (RMR by ventilated hood) and physical activity level (PAL = TEE/RMR and assessed by activity questionnaire). Measurements were taken in 88 5-year-old Pima Indian children, 24 children of women with diabetes (2-h plasma glucose ≥11.1 mmol/litre) diagnosed before or during pregnancy and 64 children of women with normal glucose tolerance (2-h plasma glucose < 7.8 mmol/litre during pregnancy and no prior history of abnormal glucose tolerance). Although birth weight was higher in children of diabetic than of nondiabetic women (3.8± 0.6 vs 3.5±0.4 kg, P<0.03), there were no differences in weight (26.4±6.9 vs 24.2±5.6 kg) or percent body fat (18O dilution; 33±8 vs 31±8%) between the groups at 5 years of age. There was no difference in TEE (6508±1109 vs 6175±942 kJ/day) or in RMR (4674±786 vs 4483±603 kJ/day) expressed as absolute values or after adjustment for weight and sex (TEE) or fat-free mass, fat mass, and sex (RMR). Physical activity level was also similar between the groups (1.40±0.12 vs 1.38±0.12). The results suggest that maternal diabetes status does not influence energy expenditure in the children by 5 years of age. Thus the greater obesity seen at older ages in the children of women with diabetes could be due to excess energy intake. Alternatively, if energy expenditure does have a role in the aetiology of obesity in these children, perhaps it does so only in older children. KW - birth weight KW - body fat KW - children KW - diabetes KW - energy metabolism KW - ethnic groups KW - glucose tolerance KW - physical activity KW - pregnancy KW - resting energy exchange KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - blood sugar tolerance KW - gestation KW - Human Reproduction and Development (VV060) KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407198&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application. AU - Howard, O. M. Z. AU - Oppenheim, J. J. AU - Hollingshead, M. G. AU - Covey, J. M. AU - Bigelow, J. AU - McCormack, J. J. AU - Buckheit, R. W. Jr. AU - Clanton, D. J. AU - Turpin, J. A. AU - Rice, W. G. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1998/// VL - 41 IS - 13 SP - 2184 EP - 2193 SN - 0022-2623 AD - Howard, O. M. Z.: Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 432 T.-B, P. O. Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982010607. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - This report describes a distamycin analogue, 2,2′-[4,4′-[[aminocarbonyl]amino]bis[N,4′-di[pyrrole-2-carboxamide-1,1′-dimethyl]]-6,8-naphthalenedisulfonic acid]hexasodium salt (NSC 651016), that selectively inhibited chemokine binding to CCR5, CCR3, CCR1, and CXCR4, but not to CXCR2 or CCR2b, and blocked chemokine-induced calcium flux. Inhibition was not due to nonspecific charge interactions at the cell surface, but was based on a specific competition for the ligand receptor interaction sites since the inhibitory effect was specific for some but not all chemoattractant receptors. NSC 651016 inhibited in vitro replication of a wide range of HIV-1 isolates, as well as HIV-2 and SIV, and exhibited in vivo and anti-HIV-1 activity in a murine model. KW - antiviral agents KW - chemokines KW - cytokines KW - human diseases KW - inhibition KW - receptors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - distamycin KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010607&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site. AU - Neamati, N. AU - Hong HuiXiao AU - Owen, J. M. AU - Sunder, S. AU - Winslow, H. E. AU - Christensen, J. L. AU - Zhao He AU - Burke, T. R. Jr. AU - Milne, G. W. A. AU - Pommier, Y. JO - Journal of Medicinal Chemistry JF - Journal of Medicinal Chemistry Y1 - 1998/// VL - 41 IS - 17 SP - 3202 EP - 3209 SN - 0022-2623 AD - Neamati, N.: Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982012165. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9007-49-2. N2 - In previous studies N,N′-bis(salicylhydrazine) was identified as a lead compound against purified recombinant HIV-1 integrase. These earlier observations were expanded by the testing of 45 novel hydrazides. Among the compounds tested, 11 derivatives exhibited 50% inhibitory concentrations of less than 3 µM. A common feature for activity among these inhibitors is the hydroxyl group of the salicyl moiety. Although the active inhibitors must contain this hydroxyl group, other structural modifications can also influence potency. Removal of this hydroxyl group or replacement with an amino, bromo, fluoro, carboxylic acid, or ethyl ether totally abolished potency against integrase. Several asymmetric structures exhibited similar potency to the symmetric lead inhibitor 1. The superimposition of the lowest-energy conformations upon one another revealed 3 sites whose properties appear important for lingand binding. Site A is composed of the 2-hydroxyphenyl, the α-keto, and the hydrazine moieties in a planar conformation. It is proposed that this site could interact with HIV-1 integrase by chelation of the metal in the integrase active site as inhibition of HIV-1 integrase catalytic activity and DNA binding were strictly Mn2+-dependent. The hydrophobic sites B and C are probably responsible for complementarity of molecular shape between ligand and receptor. The data indicate that only those compounds which possessed sites A, B, and C in a linear orientation were potent inhibitors of HIV-1 integrase. Although all the active inhibitors possessed considerable cytotoxicity and no apparent antiviral activity in CEM cells, the study presents useful information regarding ligand interaction with HIV-1 integrase protein. KW - antiviral agents KW - antiviral properties KW - binding KW - catalytic activity KW - cytotoxicity KW - derivatives KW - DNA KW - human diseases KW - inhibitors KW - integration KW - interactions KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - integrase KW - salicylhydrazine KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012165&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription. AU - Turpin, J. A. AU - Buckheit, R. W. Jr. AU - Derse, D. AU - Hollingshead, M. AU - Williamson, K. AU - Palamone, C. AU - Osterling, M. C. AU - Hill, S. A. AU - Graham, L. AU - Schaeffer, C. A. AU - Bu Ming AU - Huang MingJun AU - Cholody, W. M. AU - Michejda, C. J. AU - Rice, W. G. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 3 SP - 487 EP - 494 SN - 0066-4804 AD - Turpin, J. A.: Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics Program, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Bldg 431T-B, P.O. Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982004379. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2, 9068-38-6, 63231-63-0. N2 - Nanomolar concentrations of temacrazine (1,4-bis[6-oxo-6H-v-triazolo[4,5,1-de]acridin-5-yl)amino-propyl]piperazine inhibited acute HIV-1 infections and suppressed the production of virus from chronically and latently infected cells containing integrated proviral DNA. This bistriazoloacridone derivative exerted its mechanism of antiviral action through selective inhibition of HIV-1 transcription during the postintegrative phase of virus replication. Mechanistic studies revealed that temacrazine blocked HIV-1 RNA formation without interference with the transcription of cellular genes or with events associated with the HIV-1 Tat and Rev regulatory proteins. Although temacrazine inhibited the in vitro 3′ processing and strand transfer activities of HIV-1 integrase, with a 50% inhibitory concentration of approximately 50 nM, no evidence of an inhibitory effect on the intracellular integration of proviral DNA into the cellular genome during the early phase of infection could be detected. Furthermore, temacrazine did not interfere with virus attachment or fusion to host cells or the enzymatic activities of HIV-1 reverse transcriptase or protease, and the compound was not directly virucidal. Demonstration of in vivo anti-HIV-1 activity by temacrazine identifies bistriazoloacridones as a new class of pharmaceuticals that selectively blocks HIV-1 transcription. KW - antiviral agents KW - concentration KW - derivatives KW - DNA KW - drugs KW - effects KW - genes KW - genomes KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - infection KW - infections KW - inhibition KW - interference KW - proteinases KW - proteins KW - replication KW - reverse transcriptase KW - RNA KW - transcription KW - treatment KW - viral regulatory proteins KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bistriazolacridones KW - deoxyribonucleic acid KW - DNA transcription KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - medicines KW - pharmaceuticals KW - proteases KW - ribonucleic acid KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004379&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite. AU - Rogers, M. J. AU - Cundliffe, E. AU - McCutchan, T. F. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 3 SP - 715 EP - 716 SN - 0066-4804 AD - Rogers, M. J.: Growth and Development Section, Laboratory of Parasitic Diseases, Building 4, Room B1-28, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980804556. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology N2 - The in vitro antimalarial efficacy of micrococcin was tested against Plasmodium falciparum. This thiopeptide antibiotic was a potent growth inhibitor, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding concentrations of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite. KW - antimalarials KW - antiprotozoal agents KW - efficacy KW - growth inhibitors KW - in vitro KW - mode of action KW - novel antiprotozoal agents KW - parasites KW - protein synthesis KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - micrococcin KW - protein biosynthesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804556&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Efficacies of zinc-finger-active drugs against Giardia lamblia. AU - Nash, T. AU - Rice, W. G. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 6 SP - 1488 EP - 1492 SN - 0066-4804 AD - Nash, T.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980807536. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 97-77-8. Subject Subsets: Protozoology N2 - Twenty-nine of 34 (85%) zinc-finger-active compounds used at concentrations ≤300 µM inhibited the in vitro growth of Giardia lamblia [G. duodenalis]. The most active compound, disulfiram (Antabuse), was effective at 1.23 ± 0.32 µM. In the adult mouse model, significant in vivo activity of disulfiram (25 mg twice daily for 4 days, administered by gavage as a fine suspension in 200 µl water) was demonstrated by increased cure rates and decreased parasite burdens. KW - antiprotozoal agents KW - disulfiram KW - drug therapy KW - efficacy KW - experimental infections KW - in vitro KW - inhibitors KW - laboratory animals KW - novel antiprotozoal agents KW - parasites KW - Giardia duodenalis KW - mice KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - chemotherapy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807536&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata. AU - Miyazaki, H. AU - Miyazaki, Y. AU - Geber, A. AU - Parkinson, T. AU - Hitchcock, C. AU - Falconer, D. J. AU - Ward, D. J. AU - Marsden, K. AU - Bennett, J. E. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 7 SP - 1695 EP - 1701 SN - 0066-4804 AD - Miyazaki, H.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19981202106. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - Sequential C. glabrata [Torulopsis glabrata] isolates were obtained from the mouth of an HIV-1-infected patient who was receiving high doses of fluconazole (800 mg/day) for oropharyngeal candidosis. Fluconazole-susceptible colonies were replaced by resistant colonies that showed both increased fluconazole efflux and increased transcripts of a gene which coded for a protein with 72.5% identity to Pdr5p, an ABC multidrug transporter in Saccharomyces cerevisiae. The deduced protein had an MW of 175 kDa and was composed of 2 homologous halves, each with 6 putative transmembrane domains and highly conserved sequences of ATP-binding domains. When the earliest and most azole-susceptible isolate of T. glabrata from this patient was exposed to fluconazole, increased transcripts of the PDR5 homologue appeared, linking azole exposure to regulation of this gene. KW - antifungal agents KW - candidosis KW - drug resistance KW - drug therapy KW - fluconazole KW - genes KW - infections KW - men KW - mouth KW - Candida glabrata KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Torulopsis KW - Pezizomycotina KW - Ascomycota KW - fungi KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - candidiasis KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety, tolerance, and pharmacokinetics of a small unilamellar liposomal formulation of amphotericin B (AmBisome) in neutropenic patients. AU - Walsh, T. J. AU - Yeldandi, V. AU - McEvoy, M. AU - Gonzalez, C. AU - Chanock, S. AU - Freifeld, A. AU - Seibel, N. I. AU - Whitcomb, P. O. AU - Jarosinski, P. AU - Boswell, G. AU - Bekersky, I. AU - Alak, A. AU - Buell, D. AU - Barret, J. AU - Wilson, W. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 9 SP - 2391 EP - 2398 SN - 0066-4804 AD - Walsh, T. J.: Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202598. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The safety, tolerance and pharmacokinetics of a small unilamellar liposomal formulation of amphotericin B (AmBisome) administered for empirical antifungal therapy were evaluated for 36 persistently febrile neutropenic adults from the USA receiving cancer chemotherapy and bone marrow transplantation. The protocol was an open-label, sequential-dose-escalation, multi-dose pharmacokinetic study which enrolled a total of 8-12 patients in each of the 4 dosage cohorts. Each cohort received daily doses of either 1.0, 2.5, 5.0 or 7.5 mg/kg of amphotericin B in the form of AmBisome. The study population consisted of patients (aged 13-80 years) with neutropenia (absolute neutrophil count <500/mm³) who were eligible to receive empirical antifungal therapy. Patients were monitored for safety and tolerance by frequent laboratory examinations and the monitoring of infusion-related reactions. Efficacy was assessed by monitoring for the development of invasive fungal infection. The pharmacokinetic parameters of AmBisome were measured as those of amphotericin B by HPLC. Noncompartmental methods were used to calculate pharmacokinetic parameters. AmBisome administered as a 1-h infusion in this population was well tolerated and was seldom associated with infusion-related toxicity. Infusion-related side effects occurred in 15 (5%) of all 331 infusions and only 2 patients (5%) required premedication. Serum creatinine, potassium and magnesium levels were not significantly changed from baseline in any of the dosage cohorts, and there was no net increase in serum transaminase levels. AmBisome followed a nonlinear dosage relationship that was consistent with reticuloendothelial uptake and redistribution. There were no breakthrough fungal infections during empirical therapy with AmBisome. It is concluded that AmBisome administered to febrile neutropenic patients in this study was well tolerated, was seldom associated with infusion-related toxicity, was characterized by nonlinear saturation kinetics, and was effective in preventing breakthrough fungal infections. KW - amphotericin B KW - antifungal agents KW - application methods KW - drug formulations KW - drug therapy KW - liposomes KW - pharmacokinetics KW - safety KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - fungistats KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202598&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifungal activity of the pradimicin derivative BMS 181184 in the treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits. AU - Gonzalez, C. E. AU - Groll, A. H. AU - Giri, N. AU - Shetty, D. AU - Al-Mohsen, I. AU - Sein, T. AU - Feuerstein, E. AU - Bacher, J. AU - Piscitelli, S. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 9 SP - 2399 EP - 2404 SN - 0066-4804 AD - Gonzalez, C. E.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202599. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The activity of BMS 181184 was evaluated in a model of invasive pulmonary Aspergillus fumigatus infection in persistently neutropenic rabbits and compared with that of amphotericin B deoxycholate. BMS 181184 at total daily doses of 50 and 150 mg/kg was at least as effective as amphotericin B at 1 mg/kg once daily in conferring survival and had comparable activity in reducing organism-mediated tissue injury and excess lung weight. Although treatment at all dosing regimens of BMS 181184 resulted in significant reductions in fungal tissue burden compared with untreated controls, equivalence to amphotericin B occurred only at the higher dosage level. Similar observations were made in bronchoalveolar lavage fluid cultures obtained postmortem. Monitoring of the animals through ultrafast computerized tomography scan revealed a marked resolution of pulmonary lesions during treatment with BMS 181184. The compound was well tolerated at all dosing regimens and no toxicity was noted. Pharmacokinetic studies revealed nonlinear drug disposition with increased clearance at higher dosages and some evidence for extravascular drug accumulation. It is concluded that BMS 181184 had excellent activity in the treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - aspergillosis KW - drug therapy KW - efficacy KW - experimental infections KW - immunocompromised hosts KW - infections KW - lungs KW - safety KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-fungal properties KW - BMS 181184 KW - chemotherapy KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - pradimicins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202599&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifungal efficacy, safety and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits. AU - Petraitis, V. AU - Petraitiene, R. AU - Groll, A. H. AU - Bell, A. AU - Callender, D. P. AU - Sein, T. AU - Schaufele, R. L. AU - McMillian, C. L. AU - Bacher, J. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1998/// VL - 42 IS - 11 SP - 2898 EP - 2905 SN - 0066-4804 AD - Petraitis, V.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981203126. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The antifungal efficacy and safety of LY303366 were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Treatment study groups were either not treated (controls) or treated with amphotericin B (AmB; 1 mg/kg daily) or with LY303366 (at 1, 5, 10, and 20 mg/kg daily). In rabbits treated with LY303366, there was a significant improvement in survival and a reduction in organism-mediated pulmonary injury measured by the number of infarcts, total lung weight and ultrafast computerized tomography scan pulmonary lesion score. Rabbits receiving prophylactic LY303366 also demonstrated significant improvement in survival and reduction in organism-mediated pulmonary injury. AmB and LY303366 had comparable therapeutic efficacies by all parameters with the exception of reduction in tissue burden of A. fumigatus, where AmB was superior to LY303366. LY303366 demonstrated a dose-dependent effect on hyphal injury with progressive truncation, swelling and vacuolization. LY303366 administered in single doses of 1, 5, 10 and 20 mg/kg demonstrated dose-proportional increases in the maximum concentration of drug in plasma and the area under the concentration-time curve from 0 to 72 h with no changes in plasma drug clearance. The 1-mg/kg dosage maintained plasma drug levels above the minimum inhibitory concentration (MIC) for 18 h, and dosages of ≥5 mg/kg maintained plasma drug levels above the MIC for the entire 24-h dosing interval. There was no significant elevation of the concentrations of hepatic transaminases or creatinine in serum in LY303366-treated rabbits. It is concluded that LY303366 improved survival and decreased pulmonary injury with no apparent toxicity in the treatment and prevention of invasive pulmonary aspergillosis in persistently neutropenic rabbits. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - aspergillosis KW - drug therapy KW - echinocandins KW - efficacy KW - experimental infections KW - lungs KW - pharmacokinetics KW - safety KW - Aspergillus fumigatus KW - rabbits KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-fungal properties KW - chemotherapy KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - LY303366 KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981203126&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Telephone support groups for HIV-positive mothers whose children have died of AIDS. AU - Wiener, L. S. JO - Social Work JF - Social Work Y1 - 1998/// VL - 43 IS - 3 SP - 279 EP - 285 AD - Wiener, L. S.: Pediatric HIV Psychosocial Support Program, National Cancer Institute, NIH, Bethesda, MD, USA. N1 - Accession Number: 19982007247. Publication Type: Journal Article. Language: English. Number of References: 11 ref. KW - acquired immune deficiency syndrome KW - children KW - death KW - human diseases KW - human immunodeficiency viruses KW - mothers KW - psychosocial aspects KW - social services KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007247&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Anxiety and depression among HIV-infected heterosexuals-a report from India. AU - Chandra, P. S. AU - Ravi, V. AU - Desai, A. AU - Subbakrishna, D. K. JO - Journal of Psychosomatic Research JF - Journal of Psychosomatic Research Y1 - 1998/// VL - 45 IS - 5 SP - 401 EP - 409 SN - 0022-3999 AD - Chandra, P. S.: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, India. N1 - Accession Number: 19982014213. Publication Type: Journal Article. Language: English. Number of References: 22 ref. N2 - The aim of the study was to study factors related to anxiety, depression, and suicidal ideation among HIV-seropositive heterosexuals soon after being tested for their HIV status for the first time. Anxiety, depression, and suicidal ideation were assessed among 51 HIV-seropositive heterosexual men and women at various stages of HIV infection. All assessments were done between 4 and 6 weeks after revelation of positive serostatus. Psychosocial variables such as quality of family relationships and substance use and sociodemographic details such as gender, income, education, and residence were studied for their association with psychiatric morbidity. Illness details studied for their association with psychiatric morbidity included stage of HIV infection, spouse's HIV status, presence of physical illness, and pain. Depression was present in 40% and anxiety in 36% of the sample. Serious suicidal intent was seen in 14%. Multiple regression analysis indicated that presence of pain, concurrent alcohol abuse, poor family relations, and presence of AIDS in the spouse were significant factors associated with depression, anxiety, and suicidal ideation. KW - acquired immune deficiency syndrome KW - anxiety KW - depression KW - families KW - human diseases KW - human immunodeficiency viruses KW - psychosocial aspects KW - suicide KW - India KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - AIDS KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014213&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adhesion of Plasmodium gallinaceum ookinetes to the Aedes aegypti midgut: sites of parasite attachment and morphological changes in the ookinete. AU - Zieler, H. AU - Garon, C. F. AU - Fischer, E. R. AU - Shahabuddin, M. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1998/// VL - 45 IS - 5 SP - 512 EP - 520 SN - 1066-5234 AD - Zieler, H.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990801357. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Plasmodium gallinaceum ookinetes adhered to A. aegypti midgut epithelia when purified ookinetes and isolated midguts were combined in vitro. Ookinetes preferentially bound to the microvillated luminal surface of the midgut and appeared to interact with 3 types of structures on the midgut surface. They adhered to and migrated through a network-like matrix, termed the microvilli-associated network, that covers the surface of the microvilli. This network forms on the luminal midgut surface in response to blood or protein meals. The ookinetes also bound directly to the microvilli on the surface of the midgut and were occasionally found immersed in the thick microvillar layer; and ookinetes associated with accumulations of vesicular structures found interspersed between the microvillated cells of the midgut. The origin of these vesicular structures is unknown, but they correlated with the surface of midgut cells invaded by ookinetes as observed by transmission electron microscopy. After binding to the midgut, ookinetes underwent extensive morphological changes: they frequently developed one or more annular constrictions and their surface roughened considerably, suggesting that midgut components remain bound to the parasite surface. The observations suggest that, in a natural infection, the ookinete interacts in a sequential manner with specific components of the midgut surface. Initial binding to the midgut surface may activate the ookinete and cause morphological changes in preparation for invasion of the midgut cells. KW - cell invasion KW - cells KW - cytoadherence KW - development KW - developmental stages KW - epithelium KW - host parasite relationships KW - in vitro KW - microvilli KW - midgut KW - morphology KW - ookinetes KW - parasites KW - transmission electron microscopy KW - ultrastructure KW - vesicles KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - cell adhesion KW - growth phase KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801357&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Contextual determinants of maternal mortality in rural Pakistan. AU - Midhet, F. AU - Becker, S. AU - Berendes, H. W. JO - Social Science & Medicine JF - Social Science & Medicine Y1 - 1998/// VL - 46 IS - 12 SP - 1587 EP - 1598 SN - 0277-9536 AD - Midhet, F.: National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B05, Bethesda, MD 20892, USA. N1 - Accession Number: 19981811250. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Rural Development; Tropical Diseases N2 - An investigation is presented of the risk factors associated with maternal mortality in 16 rural districts of Baluchistan and the Northwest Frontier (NWFP) provinces of Pakistan. A nested case-control study comprising 261 cases (maternal deaths reported during last five years) and 9135 controls (women who survived a pregnancy during last five years) was designed. Using contextual analysis, the paper estimates the interactions between the biological risk factors of maternal mortality and the district-level indicators of health services. Women under 19 or over 39 yr of age, those having their first birth, and those having a previous history of fetal loss were at greater risk of maternal death. Staffing patterns of peripheral health facilities in the district and accessibility of essential obstetric care (EOC) were significantly associated with maternal mortality. These indicators also modified the effects of the biological risk factors of maternal mortality. For example, nulliparous women living in the under-served districts were at greater risk than those living in the better-served districts. It is concluded that better staffing of peripheral health facilities and improved access to EOC could reduce the risk of maternal mortality among women in rural Baluchistan and the NWFP. KW - age KW - evaluation KW - health services KW - maternal mortality KW - maternity services KW - pregnancy KW - risk KW - rural development KW - women KW - Balochistan KW - North-West Frontier (Pakistan) KW - Pakistan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pakistan KW - South Asia KW - Asia KW - Developing Countries KW - Commonwealth of Nations KW - Baluchistan KW - gestation KW - Khyber-Pakhtunkhwa KW - North West Frontier Province KW - North-West Frontier Province KW - NWFP KW - Pakistan Northwest Frontier KW - Health Services (UU350) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981811250&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fatigue in HIV-infected men receiving investigational interleukin-2. AU - Grady, C. AU - Anderson, R. AU - Chase, G. A. JO - Nursing Research JF - Nursing Research Y1 - 1998/// VL - 47 IS - 4 SP - 227 EP - 234 AD - Grady, C.: Department of Clinical Bioethics, W. G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982012087. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 102524-44-7, 85898-30-2. N2 - Against a background of fatigue related to HIV infection and its multiple manifestations and treatments, therapy with IL-2 dramatically increases the experience of fatigue. Although this increase is transient and tends to return to baseline by 1 month, during that month the patient's life function and quality may be severely affected. KW - adverse effects KW - fatigue KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunotherapy KW - interleukin 2 KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - tiredness KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012087&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of JC virus in two African cases of progressive multifocal leukoencephalopathy including identification of JCV type 3 in a Gambian AIDS patient. AU - Stoner, G. L. AU - Agostini, H. T. AU - Ryschkewitsch, C. F. AU - Mazló, M. AU - Gullotta, F. AU - Wamukota, W. AU - Lucas, S. JO - Journal of Medical Microbiology JF - Journal of Medical Microbiology Y1 - 1998/// VL - 47 IS - 8 SP - 733 EP - 742 SN - 0022-2615 AD - Stoner, G. L.: Laboratory of Experimental Neuropathology, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992000106. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating central nervous system (CNS) infection, affecting mainly oligodendrocytes, but also occasional astrocytes. In the USA, Europe and Asia, PML is caused by the human polyomavirus JC virus (JCV) and in autopsy series occurs in about 4-7% of AIDS patients. In Africa, the prevalence of PML in AIDS patients is uncertain and the causative agent is unknown. This study reports immunocytochemical and PCR confirmation of PML in the CNS of an AIDS patient dying in Uganda, East Africa (case 1). In a Gambian patient infected with HIV-2 who died 3 months after onset of AIDS/PML in Germany (case 2), it was possible to confirm the identity of the virus by DNA sequencing of the PCR amplified JCV product. This African genotype of the virus (type 3) showed an unusual re-arrangement of the regulatory region, and could be distinguished at several sites from East African and African-American JCV strains described previously. This study has confirmed that PML is a complication of African AIDS as it is in Europe and the USA, and that JCV type 3 is pathogenic in African AIDS patients. Furthermore, the finding of an African genotype of JCV in a patient dying in Germany suggests that in this individual JCV represented a latent infection acquired in Africa. KW - acquired immune deficiency syndrome KW - detection KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - identification KW - progressive multifocal leukoencephalopathy KW - JC polyomavirus KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - JC virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-related risk behaviors among psychiatric inpatients in India. AU - Chopra, M. P. AU - Eranti, S. S. V. AU - Chandra, P. S. JO - Psychiatric Services JF - Psychiatric Services Y1 - 1998/// VL - 49 IS - 6 SP - 823 EP - 825 AD - Chopra, M. P.: Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560 029, India. N1 - Accession Number: 19982008519. Publication Type: Journal Article. Language: English. Number of References: 9 ref. N2 - This study explored patterns of risk behaviour and knowledge about HIV and AIDS among patients in an inpatient psychiatric facility in south India. 59 consecutive patients admitted to a state psychiatric hospital were interviewed using a semistructured questionnaire. 51% had a history of recent risk behaviour, and 86% had inadequate knowledge about AIDS. The most common high-risk behaviour was unprotected heterosexual intercourse with a high-risk partner. There was no correlation between knowledge and high-risk behaviour. The findings underscore the need to specifically tailor intervention programmes. KW - acquired immune deficiency syndrome KW - behaviour KW - heterosexuality KW - HIV infections KW - hospitals KW - human diseases KW - human immunodeficiency viruses KW - infection KW - mental disorders KW - patients KW - psychiatry KW - questionnaires KW - risk behaviour KW - sexual intercourse KW - India KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - AIDS KW - behavior KW - heterosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - mental illness KW - psychiatric disorders KW - risk behavior KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008519&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Validity of self-reported fat distribution in young adults: the CARDIA study. AU - Bild, D. E. AU - Sholinsky, P. D. AU - Schreiner, P. J. AU - Hilner, J. E. AU - Swanson, C. A. JO - Journal of Clinical Epidemiology JF - Journal of Clinical Epidemiology Y1 - 1998/// VL - 51 IS - 5 SP - 407 EP - 413 SN - 0895-4356 AD - Bild, D. E.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19981409876. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 57-88-5, 9004-10-8. Subject Subsets: Human Nutrition N2 - To determine the validity of self-reported information on body fat distribution, relationships between reported location of weight gain and measured waist-to-hip ratio (WHR), HDL cholesterol (HDL-C) and fasting insulin were analysed in 5115 black and white men and women aged 18-30 years from Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California in the USA. In black men, WHR adjusted for age and body mass index (BMI) ranged from 0.833 among those reporting upper and central weight gain to 0.812 among those reporting lower body weight gain (trend across 5 reported fat distribution categories, P=0.0004). Corresponding values were, for white men, 0.852-0.831; for black women, 0.777-0.721; and for white women, 0.772-0.701 (each P<0.0001). Reported fat distribution was associated with HDL-C in women, but not in men, and with fasting insulin in all groups. It is concluded that while these associations were somewhat weaker than with measured WHR, self-reported fat distribution does provide valid information about body fat distribution in young adults, particularly women. KW - anthropometric dimensions KW - blood KW - blood lipids KW - body fat KW - body weight KW - cholesterol KW - distribution KW - ethnic groups KW - ethnicity KW - high density lipoprotein KW - insulin KW - lipoproteins KW - men KW - risk factors KW - sex differences KW - weight gain KW - women KW - Alabama KW - California KW - Illinois KW - Minnesota KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - East South Central States of USA KW - Gulf States of USA KW - North America KW - OECD Countries KW - Southeastern States of USA KW - Southern States of USA KW - USA KW - Pacific States of USA KW - Western States of USA KW - Corn Belt States of USA KW - North Central States of USA KW - East North Central States of USA KW - Lake States of USA KW - West North Central States of USA KW - anthropometric measurements KW - ethnic differences KW - United States of America KW - Human Nutrition (General) (VV100) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981409876&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Play development in children with HIV infection : a pilot study. AU - Parks, R. A. AU - Oakley, F. AU - Fonseca, M. JO - American Journal of Occupational Therapy JF - American Journal of Occupational Therapy Y1 - 1998/// VL - 52 IS - 8 SP - 672 EP - 675 AD - Parks, R. A.: Rehabilitation Medicine Department, National Institutes of Health, Bldg. 10, Rm 6S-235, 10 Center Drive, MSC 1604, Bethesda, MD 20892-1604, USA. N1 - Accession Number: 19982013596. Publication Type: Journal Article. Language: English. Number of References: 5 ref. KW - behaviour KW - children KW - development KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - paediatrics KW - psychosocial aspects KW - therapy KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - behavior KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - pediatrics KW - therapeutics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013596&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neurocysticercosis - a clinicopathological appraisal. AU - Kudesia, S. AU - Vani Santosh AU - Pal, L. AU - Sarala Das AU - Shankar, S. K. JO - Medical Journal Armed Forces India JF - Medical Journal Armed Forces India Y1 - 1998/// VL - 54 IS - 1 SP - 13 EP - 18 SN - 0377-1237 AD - Kudesia, S.: National Institute of Mental Health and Neurosciences, Bangalore 560029, India. N1 - Accession Number: 19980805935. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Helminthology; Tropical Diseases N2 - Between 1977 and 1994, 153 cases of neurocysticercosis were histopathologically diagnosed on surgically resected and autopsied material in Karnataka State, India. Variable numbers of cysts were found, mostly in the cerebral parenchyma (98 cases), followed by the cerebral ventricles (14) and subarachnoid spaces (12). Cysts were rarely located in the cerebellum (8), brain stem (4) or spinal cord (6). Patients harbouring parenchymal cysts manifested predominantly with seizures and encephalitis whereas those with ventricular and/or cisternal cysts presented with features of chronic meningitis and hydrocephalus. Unusual clinical manifestations were psychiatric symptoms with behavioural abnormalities and stroke in the young as a result of cysticercal meningitis with associated arteritis. Primary cysticercal abscess in the brain parenchyma was recorded in 3 cases. In endemic areas, the co-existence of neurocysticercosis appears to enhance morbidity and mortality due to Japanese encephalitis (31 cases). KW - brain KW - brain diseases KW - brain stem KW - central nervous system KW - cestode infections KW - cestode larvae KW - clinical aspects KW - diagnosis KW - helminths KW - histopathology KW - human diseases KW - infections KW - Japanese encephalitis KW - metacestodes KW - mixed infections KW - morbidity KW - mortality KW - nervous system diseases KW - neurocysticercosis KW - parasites KW - pathology KW - spinal cord KW - India KW - Karnataka KW - Japanese encephalitis virus KW - man KW - Taenia solium KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Taenia KW - Taeniidae KW - Eucestoda KW - Cestoda KW - Platyhelminthes KW - invertebrates KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - brain disorders KW - cerebrum KW - clinical picture KW - CNS KW - death rate KW - multiple infections KW - Mysore KW - neuropathy KW - parasitic worms KW - pork tapeworm KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Towards developing HIV-2 lentivirus based retroviral vectors for gene therapy: dual gene expression in the context of HIV-2 LTR and Tat. AU - Sadaie, M. R. AU - Zamani, M. AU - Whang, S. AU - Sistron, N. AU - Arya, S. K. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1998/// VL - 54 IS - 2 SP - 118 EP - 128 SN - 0146-6615 AD - Sadaie, M. R.: Basic Research Laqboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bldg. 37, Rm 6C24, Bethesda, MD 20892. N1 - Accession Number: 19982010685. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - The expression of genes specifically directed by the HIV-2 LTR and Tat in a prototypic minimal transfer vector was investigated. The expression of a gene in a dual gene configuration depended upon its position in the transcriptional unit and the insertion of an internal translational initiation mechanism improved the expression of the downstream gene. Apparently not sufficiently appreciated previously, these effects were promoter and cell-type dependent. These data also suggest that the commonly used cellular or viral promoters may be orders of magnitude less effective than HIV-2 LTR in the presence of Tat, and thus may not be useful as internal promoters in the context of the HIV-2 LTR:Tat regulatory loop. KW - acquired immune deficiency syndrome KW - disease vectors KW - gene expression KW - gene therapy KW - human diseases KW - promoters KW - vectors KW - Human immunodeficiency virus 2 KW - Lentivirus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - AIDS KW - human immunodeficiency virus type 2 KW - promoter region KW - promoter sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010685&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase. AU - Fidock, D. A. AU - Nomura, T. AU - Wellems, T. E. JO - Molecular Pharmacology JF - Molecular Pharmacology Y1 - 1998/// VL - 54 IS - 6 SP - 1140 EP - 1147 SN - 0026-895X AD - Fidock, D. A.: Malaria Genetics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990806002. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 516-21-2, 9002-03-3, 500-92-5. Subject Subsets: Protozoology N2 - This paper describes a transformation system, involving selection by the dihydrofolate reductase (DHFR) inhibitor WR99210 of cycloguanil- sensitive or resistant Plasmodium falciparum parasites transformed with either wild-type or methotrexate-resistant human DHFR, that has application for the screening of P. falciparum-specific DHFR inhibitors that are active against drug-resistant parasites. Using this system in vitro, it was found that cycloguanil had a mode of pharmacological action distinct from the activity of its parent compound proguanil. Cycloguanil acted specifically on P. falciparum DHFR and had no other significant target - transformation with human DHFR (which can substitute for its P. falciparum equivalent) gave a very high degree of protection against cycloguanil. In contrast, transformation had very little effect on proguanil susceptibility, indicating that DHFR is not the target of proguanil, and that proguanil acts as an antimalarial in its native form as well as after conversion to cycloguanil. The authors propose a strategy of combination chemotherapy involving the use of multiple parasite-specific inhibitors that act on the same molecular target and maintain, in combination, their effectiveness against alternative forms of resistance that arise from different sets of point mutations in the target. KW - antimalarials KW - antiprotozoal agents KW - cycloguanil KW - dihydrofolate reductase KW - drug resistance KW - drug targets KW - in vitro KW - inhibitors KW - malaria KW - mode of action KW - parasites KW - proguanil KW - screening KW - techniques KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - chlorguanide KW - chloroguanide KW - cycloguanil embonate KW - screening tests KW - tetrahydrofolate dehydrogenase KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990806002&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protease inhibitors for the treatment of human immunodeficiency virus infection. AU - Kakuda, T. N. AU - Struble, K. A. AU - Piscitelli, S. C. JO - American Journal of Health-System Pharmacy JF - American Journal of Health-System Pharmacy Y1 - 1998/// VL - 55 IS - 3 SP - 233 EP - 254 AD - Kakuda, T. N.: Department of Pharmacy, Warren G. Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 1N-257, MSC 1196, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004112. Publication Type: Journal Article. Language: English. Number of References: 127 ref. N2 - The pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration of protease inhibitors are reviewed. KW - adverse effects KW - antiviral agents KW - drugs KW - human diseases KW - human immunodeficiency viruses KW - inhibitors KW - interactions KW - pharmacokinetics KW - pharmacology KW - proteinase inhibitors KW - proteinases KW - treatment KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - human immunodeficiency virus KW - medicines KW - pharmaceuticals KW - protease inhibitors KW - proteases KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004112&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selective depletion of DNA precursors. An evolving strategy for potentiation of dideoxynucleoside activity against human immunodeficiency virus. AU - Johns, D. G. AU - Gao WenYi JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1998/// VL - 55 IS - 10 SP - 1551 EP - 1556 SN - 0006-2952 AD - Johns, D. G.: Laboratory of Medicinal Chemistry, Division of Basic Sciences, Bldg. 37, Rm. 5B22, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19982007908. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 69655-05-6, 9007-49-2, 127-07-1, 63231-63-0. N2 - Since viral DNA synthesis has an absolute requirement for all 4 deoxynucleoside-5′-triphosphates (dNTPs), restriction of a single one of these is sufficient to inhibit HIV-1 replication. To date, this therapeutic strategy has been most successful when depletion of the individual dNTP is coupled with exposure to its corresponding chain-terminating dideoxynucleoside (ddN). While several examples of such combined therapy have been defined and studied in vitro, that which has been investigated most extensively at both the laboratory and the clinical level is ddATP exposure combined with dATP depletion [with dATP restriction being induced by the ribonucleotide reductase inhibitor hydroxyurea (HU) and ddATP generated from its prodrug 2′,3′-dideoxyinosine (ddI)]. Several long-term clinical trials of the hydroxyurea/2′,3′-dideoxyinosine combination have been completed, with plasma viral RNA being reduced to undetectable levels in a substantial fraction (one third to one half) of the patients treated. The major advantages of this and analogous combinations discussed in this review are their low cost relative to other current multiple drug protocols and their potential for retention of activity against drug-resistant HIV mutants. KW - antiviral agents KW - clinical trials KW - combination therapy KW - depletion KW - didanosine KW - dideoxynucleosides KW - DNA KW - drug resistance KW - genomes KW - hosts KW - human diseases KW - human immunodeficiency viruses KW - hydroxycarbamide KW - in vitro KW - metabolites KW - mutants KW - precursors KW - replication KW - reviews KW - RNA KW - synthesis KW - transcription KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - combined modality therapy KW - deoxyribonucleic acid KW - dideoxyinosine KW - DNA transcription KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - hydroxyurea KW - multimodal treatment KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007908&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2′,3′-dideoxyinosine. AU - Gao WenYi AU - Zhou BingSen AU - Johns, D. G. AU - Mitsuya, H. AU - Yen Yun JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1998/// VL - 56 IS - 1 SP - 105 EP - 112 SN - 0006-2952 AD - Gao WenYi: Experimental Retrovirology Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014879. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 69655-05-6, 127-07-1, 9047-64-7, 9068-66-0. N2 - The ribonucleotide reductase inhibitor hydroxyurea exhibits potent synergism, even at low, non-cytotoxic concentrations, with the anti-HIV-1 dideoxynucleoside 2′,3′-dideoxyinosine, bringing about failure of HIV DNA synthesis and, thus, of HIV replication. To elucidate the incompletely defined role of hydroxyurea in the hydroxyurea/dideoxyinosine interaction and, in particular, to identify the reasons for the unusual selective inhibitory action of the combination on retroviral rather than on cellular DNA synthesis, specific cDNA probes were prepared to determine the effects of low-level hydroxyurea on mammalian cell ribonucleotide reductase M1 and M2 subunit mRNA, while simultaneously quantitating the effects of the drug on cell cycle and on deoxynucleoside triphosphate pools. While dTTP, dCTP, and dGTP pools changed little or even increased in the presence of low-level hydroxyurea, there took place a rapid and specific inhibition of M2-subunit-catalyzed generation of dATP, with consequent slowing of cellular DNA synthesis and prolongation of S phase. However, the latter effect, in turn, resulted in increased M2 subunit mRNA transcription (a process blocked in G0/G1-phase cells, with full-length functional M2 transcripts being generated only during S phase) and, hence, in a return to normal levels of dATP and to a normal rate of cellular DNA synthesis. Because of this self-regulating mechanism, hydroxyurea-induced host-cell toxicity was obviated under conditions where HIV DNA synthesis, a process sensitive to both dATP depletion and the chain-terminating properties of the other inhibitory component of the combination (ddATP derived from dideoxyinosine), was unable to recover. KW - antiviral agents KW - didanosine KW - dideoxynucleosides KW - human immunodeficiency viruses KW - hydroxycarbamide KW - pharmacodynamics KW - regulation KW - ribonucleotide reductase KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - dideoxyinosine KW - drug action KW - human immunodeficiency virus KW - hydroxyurea KW - mechanism of drug action KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014879&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. AU - Ciolino, H. P. AU - Daschner, P. J. AU - Wang, T. T. Y. AU - Yeh, G. C. JO - Biochemical Pharmacology JF - Biochemical Pharmacology Y1 - 1998/// VL - 56 IS - 2 SP - 197 EP - 206 SN - 0006-2952 AD - Ciolino, H. P.: Cellular Defense and Carcinogenesis Section, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19981413248. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 458-37-7, 9035-51-2. Subject Subsets: Horticultural Science; Human Nutrition N2 - We examined the interaction of curcumin, a dietary constituent and Curcumin caused a rapid accumulation of cytochrome P450 1A1 (CYP1A1) mRNA in a time- and concentration-dependent manner, and CYP1A1 monooxygenase activity increased as measured by ethoxyresorufin-O-deethylation. Curcumin activated the DNA-binding capacity of the aryl hydrocarbon receptor (AhR) for the xenobiotic responsive element of CYP1A1 as measured by the electrophoretic-mobility shift assay (EMSA). Curcumin was able to compete with the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the AhR in isolated MCF-7 cytosol, indicating that it interacts directly with the receptor. Although curcumin could activate the AhR on its own, it partially inhibited the activation of AhR, as measured by EMSA, and partially decreased the accumulation of CYP1A1 mRNA caused by the mammary carcinogen dimethylbenzanthracene (DMBA). Curcumin competitively inhibited CYP1A1 activity in DMBA-treated cells and in microsomes isolated from DMBA-treated cells. Curcumin also inhibited the metabolic activation of DMBA, as measured by the formation of DMBA-DNA adducts, and decreased DMBA-induced cytotoxicity. It is suggested that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for the AhR and CYP1A1. Curcumin may thus be a natural ligand and substrate of the AhR pathway. KW - binding KW - cell cultures KW - curcumin KW - cytochrome P-450 KW - enzymes KW - gene expression KW - hydrocarbons KW - mammary gland neoplasms KW - neoplasms KW - prevention KW - receptors KW - cancers KW - mammary tumour KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Food Composition and Quality (QQ500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981413248&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The cloning and characterization of a novel cytochrome P450 family, CYP26, with specificity toward retinoic acid. AU - Haque, M. AU - Andreola, F. AU - DeLuca, L. M. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1998/// VL - 56 IS - 3 SP - 84 EP - 85 SN - 0029-6643 AD - Haque, M.: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 19981409786. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9035-51-2, 302-79-4. Subject Subsets: Human Nutrition N2 - Literature is briefly reviewed, describing the cloning and characterization of the CYP26 family of cytochromes in zebra fish, human and mouse tissues and the importance of this development in investigating the relationship between expression of these cytochromes and modulation of disease states, including cancer. KW - characterization KW - cytochrome P-450 KW - cytochromes KW - enzymes KW - human diseases KW - neoplasms KW - regulation KW - retinoic acid KW - reviews KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - cloning KW - tretinoin KW - vitamin A acid KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981409786&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima Indians. AU - Pratley, R. E. JO - Proceedings of the Nutrition Society JF - Proceedings of the Nutrition Society Y1 - 1998/// VL - 57 IS - 2 SP - 175 EP - 181 SN - 0029-6651 AD - Pratley, R. E.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19981411714. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - The pathogenesis of type 2 diabetes mellitus in the Pima Indians is reviewed under the following headings: who are the Pima Indians?; what is the evidence that environmental or acquired factors contribute to type 2 diabetes mellitus in Pima Indians?; what is the evidence that genetic factors contribute to the development of type 2 diabetes mellitus in Pima Indians?; Pima Indians as a model population to study the genetics of type 2 diabetes mellitus; studies of the genetics of type 2 diabetes mellitus in Pima Indians; identifying potential diabetogenic genes in Pima Indians; and gene-environment interactions in the pathogenesis of type 2 diabetes mellitus. KW - diabetes KW - diabetes mellitus KW - environmental factors KW - ethnic groups KW - genetic factors KW - pathogenesis KW - reviews KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Social Structure (UU480) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981411714&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas. AU - Hinnebusch, B. J. AU - Gage, K. L. AU - Schwan, T. G. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1998/// VL - 58 IS - 5 SP - 562 EP - 569 SN - 0002-9637 AD - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19980504747. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Medical & Veterinary Entomology N2 - In the case of bubonic plague, infective flea vectors contain large numbers of Y. pestis within a bacterial mass that blocks the flea's foregut, and only such blocked fleas are important for biological transmission. A bacterial quantitation method could therefore be used to assess the prevalence of plague-infective (blocked) fleas in a population. The authors developed a standard, curve-based, competitive polymerase chain reaction (PCR) procedure to quantitate Y. pestis in individual fleas. The quantitative PCR (Q-PCR) method equalled a colony count reference method in accuracy and precision when evaluated using mock samples and laboratory-infected fleas (Xenopsylla cheopis). The Q-PCR was more reliable than colony count, however, for field-collected fleas (Oropsylla hirsuta) and for blocked fleas collected after their death. In a sample of fleas collected from a prairie dog (Cynomys ludovicianus) colony (in Colorado, USA) in the aftermath of a plague epizootic, 48% were infected but <2% contained numbers of Y. pestis indicative of blockage. The method provides a means to monitor plague epizootics and associated risks of flea-borne transmission to humans, and is applicable to the study of other vector-borne diseases. KW - diagnostic techniques KW - disease vectors KW - ectoparasites KW - estimation KW - infectivity KW - plague KW - polymerase chain reaction KW - small mammals KW - techniques KW - wild animals KW - zoonoses KW - Colorado KW - USA KW - Cynomys KW - Cynomys ludovicianus KW - Opisocrostis KW - Opisocrostis hirsutus KW - Oropsylla KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - Sciuridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Cynomys KW - Ceratophyllidae KW - Siphonaptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - Xenopsylla KW - Pulicidae KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Opisocrostis KW - Oropsylla KW - Great Plains States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Western States of USA KW - bacterium KW - Oriental rat flea KW - Oropsylla hirsuta KW - PCR KW - United States of America KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504747&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - National Institutes of Health in the tropics. AU - Varmus, H. E. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1998/// VL - 59 IS - 1 SP - 24 EP - 28 SN - 0002-9637 AD - Varmus, H. E.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982009417. Publication Type: Journal Article. Language: English. KW - health KW - health services KW - human diseases KW - tropical medicine KW - tropics KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - tropical countries KW - tropical zones KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Health Services (UU350) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009417&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Therapy of viral hepatitis. AU - Hoofnagle, J. H. A2 - Krejs, G. J. A2 - Ferenci, P. A2 - Arnold, R. JO - Digestion JF - Digestion Y1 - 1998/// VL - 59 IS - 5 SP - 563 EP - 578 SN - 0012-2823 AD - Hoofnagle, J. H.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982013388. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Subject Subsets: Public Health N2 - This paper reviews the therapy of acute viral hepatitis due to hepatitis viruses A, B and C and chronic viral hepatitis due to hepatitis B virus, hepatitis delta virus and hepatitis C virus. KW - acute infections KW - chronic infections KW - drug therapy KW - hepatitis KW - hepatitis D KW - human diseases KW - reviews KW - viral hepatitis KW - hepatitis A virus KW - hepatitis B virus KW - hepatitis C virus KW - hepatitis delta virus KW - man KW - Hepatovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - Hepacivirus KW - Flaviviridae KW - Deltavirus KW - negative-sense ssRNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - severe infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013388&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Making the connection: perspectives on tropical medicine research in the United States. AU - James, S. L. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1998/// VL - 59 IS - 6 SP - 847 EP - 851 SN - 0002-9637 AD - James, S. L.: Parasitology and International Programs Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Solar Building, Bethesda, MD 20852, USA. N1 - Accession Number: 19992001718. Publication Type: Journal Article. Language: English. Number of References: 10 ref. N2 - This presidential address of the American Society of Tropical Medicine and Hygiene (ASTMH) was to have been delivered at the cancelled 47th annual meeting. The address discusses the connection between tropical disease research and the rest of biomedical science; the connection between ASTMH and its scientific constituency; and the connection between ASTMH and the public constituency. KW - history KW - human diseases KW - hygiene KW - research KW - tropical medicine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - american society of tropical medicine and hygiene KW - presidential address KW - studies KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001718&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato. AU - Dai JinRui AU - Hallock, Y. F. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1998/// VL - 61 IS - 3 SP - 351 EP - 353 SN - 0163-3864 AD - Dai JinRui: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Room 121, Building 1052, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19980305869. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants N2 - Three new oligostilbenes (malibatols A and B, and dibalanocarpol) and one known oligostilbene (balanocarpol) were isolated from the organic extract of the leaves of Hopea malibato. Structural elucidation of these compounds was based on interpretation of their chemical and spectral data. The balanocarpols exhibited very modest HIV-inhibitory activity, while the malibatols were cytotoxic to the host cells (CEM SS) in the antiviral assay. KW - antiviral properties KW - cells KW - chemical structure KW - cytotoxicity KW - human immunodeficiency viruses KW - leaves KW - medicinal plants KW - phenolic compounds KW - stilbenoids KW - Hopea KW - Dipterocarpaceae KW - Theales KW - Malvales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Hopea KW - anti-viral properties KW - drug plants KW - Hopea malibato KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980305869&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pyranocoumarins from tropical species of the genus Calophyllum: a chemotaxonomic study of extracts in the National Cancer Institute Collection. AU - McKee, T. C. AU - Covington, C. D. AU - Fuller, R. W. AU - Bokesch, H. R. AU - Young, S. AU - Cardellina, J. H., II AU - Kadushin, M. R. AU - Soejarto, D. D. AU - Stevens, P. F. AU - Cragg, G. M. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1998/// VL - 61 IS - 10 SP - 1252 EP - 1256 SN - 0163-3864 AD - McKee, T. C.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19980313953. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9068-38-6. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry N2 - (+)-Calanolide A, a novel dipyranocoumarin from the Malesian tree C. lanigerum var. austrocoriaceum, and a closely related compound, (-)-calanolide B, isolated from C. teysmannii var. inophylloide, are representatives of a distinct class of nonnucleoside HIV [human immunodeficiency virus]-1 specific reverse-transcriptase inhibitors under development as an AIDS [acquired immune deficiency syndrome] chemotherapeutic. NCI repository specimens totalling 315 organic extracts from 31 taxa of Calophyllum were analysed for related pyranocoumarins using a simple TLC system. Of the tested extracts, 127 were classified as 'positive'. Eight of the 31 taxa examined, representing 28 species already described (a seventh or eighth of all the species in this genus), contained prenylated coumarins, suggesting that these compounds, while sometimes abundantly present, are not widespread in the genus. Representative members of the TLC-positive extracts were partitioned between CH2Cl2 and 25% aqueous MeOH; the CH2Cl2-soluble materials were analysed by TLC and 1H NMR to confirm the presence of pyranocoumarins. The anti-HIV activity of the partitioned extracts are also presented. This study suggested that there are several distinctive coumarin chemotaxonomic markers distinguishing species of this genus. KW - acquired immune deficiency syndrome KW - antiviral plants KW - antiviral properties KW - chemical structure KW - collection KW - coumarins KW - human immunodeficiency viruses KW - medicinal plants KW - neoplasms KW - plant extracts KW - reverse transcriptase KW - species KW - tropics KW - India KW - Pacific Ocean KW - Calophyllum KW - Human immunodeficiency virus 1 KW - plants KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Calophyllum KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - oceans KW - marine areas KW - AIDS KW - anti-viral properties KW - Calophyllum lanigerum KW - Calophyllum lanigerum var. austrocoriaceum KW - Calophyllum teysmannii KW - Calophyllum teysmannii var. inophylloide KW - cancers KW - drug plants KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - medicinal herbs KW - officinal plants KW - tropical countries KW - tropical zones KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980313953&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. AU - Beutler, J. A. AU - Shoemaker, R. H. AU - Johnson, T. AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1998/// VL - 61 IS - 12 SP - 1509 EP - 1512 SN - 0163-3864 AD - Beutler, J. A.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19990301972. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Three novel geranyl stilbenes, schweinfurthins A, B and C, were isolated from the Cameroonian plant M. schweinfurthii. Their structures were determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity. KW - cell lines KW - chemical structure KW - cytotoxic compounds KW - cytotoxicity KW - medicinal plants KW - neoplasms KW - plant composition KW - stilbenoids KW - Cameroon KW - Euphorbiaceae KW - Macaranga KW - man KW - Euphorbiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Euphorbiaceae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Macaranga KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - cancers KW - chemical constituents of plants KW - drug plants KW - Macaranga schweinfurthii KW - medicinal herbs KW - officinal plants KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Non-wood Forest Products (KK540) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Non-food/Non-feed Plant Products (SS200) KW - Plant Composition (FF040) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990301972&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Saccharomyces cerevisiae-secreted fusion proteins Pfs25 and Pfs28 elicit potent Plasmodium falciparum transmission-blocking antibodies in mice. AU - Gozar, M. M. G. AU - Price, V. L. AU - Kaslow, D. C. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 1 SP - 59 EP - 64 SN - 0019-9567 AD - Gozar, M. M. G.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980805320. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 308067-58-5. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Two Plasmodium falciparum sexual-stage surface antigens, Pfs25 and Pfs28, which are candidates for use in transmission-blocking vaccines, were produced as single recombinant fusion proteins. The 39-kDa chimeric proteins, with a C-terminal His6 tag, were secreted by Saccharomyces cerevisiae, using the prepro-α-factor leader sequence to enable them to be secreted by the yeast. Pfs25-28 fusion proteins, when used to vaccinate CAF1 mice, were significantly more potent than Pfs25 or Pfs28 alone in eliciting antibodies that blocked oocyst development in Anopheles freeborni mosquitoes allowed to feed on test sera: complete inhibition of oocyst development in the mosquito midgut was achieved with fewer vaccinations, at a lower dose, and for a longer duration. The longest fusion protein gave the best results. Increased antigen-specific IgG titres and highly significant lymphoproliferative stimulation by Pfs28-containing antigens suggested the presence of an immunodominant helper T-cell epitope in the Pfs28 portion of the fusion proteins. This epitope may be responsible for the enhanced humoral response to both Pfs25 and Pfs28 antigens. Production of the fusion protein was improved 12-fold by making the gene more suitable for expression in yeast; this was done by converting Pfs28 codons to yeast-preferred codons, using a modified ADH2 promoter and incorporating a (Glu-Ala)2 repeat after the Kex2 cleavage site. KW - animal diseases KW - antibodies KW - antigens KW - disease vectors KW - epitopes KW - experimental infections KW - human diseases KW - IgG KW - immune response KW - laboratory animals KW - laboratory mammals KW - malaria KW - parasites KW - proteins KW - recombinant antigens KW - recombinant proteins KW - recombinant vaccines KW - surface antigens KW - transmission blocking antibodies KW - transmission blocking immunity KW - vaccine development KW - vector-borne diseases KW - Anopheles freeborni KW - Culicidae KW - Diptera KW - mice KW - Plasmodium falciparum KW - protozoa KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - Saccharomyces KW - Saccharomycetaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - antigenic determinants KW - antigenicity KW - fungus KW - immunity reactions KW - immunogens KW - immunological reactions KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805320&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. AU - Vázquez, N. AU - Walsh, T. J. AU - Friedman, D. AU - Chanock, S. J. AU - Lyman, C. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 1 SP - 145 EP - 150 SN - 0019-9567 AD - Vázquez, N.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981200602. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The ability of interleukin-15 (IL-15) to enhance superoxide production and antifungal activity of human monocytes was studied. After 18 and 48 h of treatment with IL-15, human elutriated monocytes manifested enhanced superoxide production in response to either phorbol myristate acetate or opsonized C. albicans blastoconidia. Similar results were obtained when monocytes were treated with IL-2, but to a lesser extent. Combination studies with IL-15 and IL-2 showed no additive or synergistic effects. Following incubation of monocytes with IL-15 for 18 h, there was no significant increase in mRNA transcripts for components of the NADPH oxidase complex, p40-phox, p47-phox and gp91-phox, indicating a post-transcriptional modulation of enhanced superoxide production. Antibodies against the γ chain of the IL-2 receptor and, to a lesser extent, against the β chain partially abrogated the IL-15-mediated enhanced superoxide production. Additionally, human monocytes showed enhanced killing activity against C. albicans after 18 h of incubation with IL-15 or IL-2, but this treatment did not enhance the ability of these cells to phagocytose C. albicans. The enhanced fungicidal activity seen after 18 h of treatment was no longer detectable after 48 h of cytokine treatment. Culture supernatants from the IL-15-treated monocytes were assayed for the presence of other pro-inflammatory cytokines. IL-15 treatment did not induce the release of detectable levels of tumour necrosis factor alpha, IL-1β, or IL-12. It is concluded that IL-15 upregulates the microbicidal activity of human monocytes against C. albicans. KW - activity KW - cytokines KW - immune response KW - immunology KW - immunostimulation KW - interleukins KW - monocytes KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - fungus KW - Hyphomycetes KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200602&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. AU - Hinnebusch, B. J. AU - Barbour, A. G. AU - Restrepo, B. I. AU - Schwan, T. G. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 2 SP - 432 EP - 440 SN - 0019-9567 AD - Hinnebusch, B. J.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19980504149. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia hermsii evades the mammalian immune system by periodically switching expression among members of 2 multigene families that encode immunogenic, antigenically distinct outer surface proteins. The type strain, B. hermsii HS1, has at least 40 complete genes and pseudogenes that participate in this multiphasic antigenic variation. Originally termed vmp (for variable major protein) genes, they have been reclassified as vsp (for variable small protein) and vlp (for variable large protein) genes, based on size and amino acid sequence similarities. To date, antigenic variation in B. hermsii has been studied only in the type strain, HS1. Nucleotide sequence comparisons of 23 B. hermsii HS1 genes revealed 5 distinct groups, the vsp gene family and 4 subfamilies of vlp genes. Polymerase chain reaction was used with family- and subfamily-specific primers, followed by restriction fragment length polymorphism analysis, to compare the vsp and vlp repertoires of HS1 and 7 other B. hermsii isolates from Washington, Idaho and California, USA. This analysis, together with pulsed-field gel electrophoresis genome profiles, revealed that the 8 isolates formed 3 distinct groups, which probably represent clonal lineages. Members of the 3 groups coexisted in the same geographic area, but they could also be isolated across large geographical distances. This population structure may result from immune selection by the host, as has been proposed for other pathogens with polymorphic antigens. KW - antigenic variation KW - antigens KW - comparisons KW - geographical variation KW - lipoproteins KW - molecular genetics KW - multigene families KW - nucleotide sequences KW - polymorphism KW - population structure KW - relapsing fever KW - California KW - Idaho KW - USA KW - Washington KW - Borrelia hermsii KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Mountain States of USA KW - Pacific Northwest States of USA KW - antigenic polymorphism KW - antigenicity KW - bacterium KW - biochemical genetics KW - DNA sequences KW - immunogens KW - outer surface proteins KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504149&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hemoglobin-induced binding of Candida albicans to the cell-binding domain of fibronectin is independent of the Arg-Gly-Asp sequence. AU - Yan, S. AU - Rodrigues, R. G. AU - Roberts, D. D. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 5 SP - 1904 EP - 1909 SN - 0019-9567 AD - Yan, S.: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201640. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology N2 - When grown in the complex medium Sabouraud broth, C. albicans expressed receptors that bind to several domains of fibronectin (FN). Growth in defined medium supplemented with 0.1% haemoglobin, however, enhanced the binding of FN to a single class of receptors, with a Kd=4.6 × 10-8M. Competitive binding assays using recombinant and proteolytic fragments of FN revealed that the cell-binding domain mediated this interaction. A recombinant 40-kDa fragment of FN consisting of type III repeats 9-13 had an inhibitory activity similar to that of the entire 120-kDa cell-binding domain, indicating that the C-terminal portion of the cell-binding domain contains the binding site. A recombinant 33-kDa fragment of the cell-binding domain and a 33-kDa fragment with the RGD sequence deleted had the same inhibitory activities, demonstrating that the RGD sequence recognized by some mammalian integrins is not required. The addition of haemoglobin to the culture medium also enhanced Candida cell adhesion to immobilized FN and to 120- and 40-kDa fragments of FN but not to the collagen-binding or fibrin I domains. Using ligand protection, a surface protein from C. albicans with an apparent molecular mass of 55 kDa was identified that was protected by both FN and the 40-kDa fragment derived from the cell-binding domain. It is concluded that haemoglobin both induces FN binding and changes the relative affinities of C. albicans for the cell- and collagen-binding domains of FN. KW - adhesion KW - candidosis KW - haemoglobin KW - pathogenesis KW - proteins KW - receptors KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - candidiasis KW - fibronectin KW - fungus KW - hemoglobin KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201640&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformans. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 5 SP - 2230 EP - 2236 SN - 0019-9567 AD - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201645. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 16 acapsular mutants of C. neoformans induced by 4-nitroquinoline-1-oxide were obtained and the acapsular phenotype of 1 of these mutants was complemented. The cloned gene was designated CAP60 and deletion of this newly described capsule-associated gene resulted in an acapsular phenotype. The proposed 67-kDa Cap60p contains 592 amino acids and appears to have a putative transmembrane domain close to the N terminus. DNA sequence analysis revealed that CAP60 has similarity to CAP59 at the centre portion of its coding regions. Contour-clamped homogeneous electric field blot analysis suggested that these 2 genes are on the same chromosome. CAP60 and CAP59, however, could not be functionally substituted for each other by direct complementation or by domain swap experiments. In addition, CAP60 is closely linked to a gene which is similar to a cellulose growth-specific gene of Agaricus bisporus, CEL1. Immunogold electron microscopy studies of the epitope-tagged CAP60 gene revealed that Cap60p was primarily localized to the nuclear membrane. Animal model studies in mice indicated that CAP60 is essential for virulence. It is concluded that CAP60 is required for both capsule formation and virulence. KW - cryptococcosis KW - experimental infections KW - genes KW - pathogenicity KW - virulence KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - capsule KW - european blastomycosis KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201645&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria. AU - Stevenson, B. AU - Bono, J. L. AU - Schwan, T. G. AU - Rosa, P. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 6 SP - 2648 EP - 2654 SN - 0019-9567 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19980506398. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi can contain multiple genes encoding different members of the Erp lipoprotein family. Some arthropod-borne bacteria increase the synthesis of proteins required for transmission or mammalian infection when cultures are shifted from cool, ambient air temperature to a warmer, blood temperature. The authors found that all of the erp genes known to be encoded by infectious isolate B31 were differentially expressed in culture after a change in temperature, with greater amounts of message being produced by bacteria shifted from 23 to 35°C than in those maintained at 23°C. Mice infected with B31 by tick (Ixodes scapularis) bite produced antibodies that recognized each of the Erp proteins within 4 weeks of infection, suggesting that the Erp proteins are produced by the bacteria during the early stages of mammalian infection and may play roles in transmission from ticks to mammals. Several of the B31 Erp proteins were also recognized by antibodies from patients with Lyme disease and may prove to be useful antigens for diagnostic testing or as components of a protective vaccine. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are U72776, U72998, U78764 and AF020657. KW - antibodies KW - biosynthesis KW - disease transmission KW - disease vectors KW - DNA KW - genes KW - immune response KW - laboratory animals KW - Lyme disease KW - molecular genetics KW - nucleotide sequences KW - proteins KW - temperature KW - Acari KW - Arachnida KW - Borrelia burgdorferi KW - Ixodes scapularis KW - man KW - mice KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Muridae KW - rodents KW - bacterium KW - biochemical genetics KW - deoxyribonucleic acid KW - DNA sequences KW - immunity reactions KW - immunological reactions KW - lyme borreliosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506398&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phase 1 evaluation of Vibrio cholerae O1, serotype Inaba, polysaccharide-cholera toxin conjugates in adult volunteers. AU - Gupta, R. K. AU - Taylor, D. N. AU - Bryla, D. A. AU - Robbins, J. B. AU - Szu, S. C. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 7 SP - 3095 EP - 3099 SN - 0019-9567 AD - Gupta, R. K.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2720, USA. N1 - Accession Number: 19982013325. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Tropical Diseases N2 - Conjugate vaccines were prepared by binding hydrazine-treated lipopolysaccharide (DeALPS) from Vibrio cholerae O1, serotype Inaba, to cholera toxin (CT) variants CT-1 and CT-2. Volunteers (n=75) in the USA were injected with either 25 µg of DeALPS, alone or as a conjugate, or the licensed cellular vaccine containing 4 × 109 organisms each of serotypes Inaba and Ogawa per ml. No serious adverse reactions were observed. DeALPS alone did not elicit serum LPS or vibriocidal antibodies in mice and only low levels of immunoglobulin M (IgM) anti-LPS in the volunteers. Recipients of the cellular vaccine had the highest IgM anti-LPS levels, but the difference was not statistically significant from that elicited by the conjugates. The conjugates elicited the highest levels of IgG anti-LPS (DeALPS-CT-2 > DeALPS-CT-1 > cellular vaccine). Both conjugates and the cellular vaccine elicited vibriocidal antibodies: after 8 months, recipients of cellular vaccine had the highest geometric mean titre (1249), followed by DeALPS-CT-2 (588) and DeALPS-CT-1 (330). The correlation coefficient between IgG anti-LPS and 2-mercaptoethanol (2-ME)-resistant vibriocidal antibodies was 0.81 (P=0.0004). Convalescent sera from cholera patients in Mexico had a mean vibriocidal titre of 2525 that was removed by treatment with 2-ME. The vibriocidal activities of sera from all vaccine groups and from the patients were absorbed (>75%) by LPS but not by either CT-1 or CT-2. Conjugate-induced IgG vibriocidal antibodies persisted longer than those elicited by the whole-cell vaccine. Both conjugates, but not the cellular vaccine, elicited IgG anti-CT. KW - conjugate vaccines KW - evaluation KW - human diseases KW - immune response KW - immunization KW - polysaccharides KW - vaccination KW - volunteers KW - USA KW - man KW - Vibrio cholerae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - complex carbohydrates KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance. AU - James, S. L. AU - Cheever, A. W. AU - Caspar, P. AU - Wynn, T. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 8 SP - 3510 EP - 3518 SN - 0019-9567 AD - James, S. L.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19990804117. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4, 10102-43-9. Subject Subsets: Helminthology N2 - Inducible nitric oxide synthase (iNOS)-deficient mice were used to determine the role of nitric oxide (NO) in mice vaccinated with irradiated cercariae of Schistosoma mansoni. ELISA and reverse transcriptase PCR analysis showed that vaccinated iNOS-deficient mice developed exacerbated type 1 cytokine responses in the lungs, the site where resistance to infection is primarily manifested. In addition, parasite-specific IgG2a and IgG2b antibody responses were significantly increased in vaccinated iNOS-deficient animals and total IgE antibody levels in serum were decreased relative to those in wild-type controls. Surprisingly, since resistance in this vaccine model is largely Th1 dependent and since Th1-related cellular and humoral immune responses were found to be exacerbated in vaccinated iNOS-deficient mice, vaccine-elicited protective immunity against challenge infection was found to be reduced. These findings demonstrate that iNOS plays a paradoxical role in immunity to S. mansoni, both in the effector mechanism of resistance and in the down regulation of the type 1 cytokine response, which is ultimately required for NO production. KW - cercariae KW - cytokines KW - experimental infections KW - helminths KW - IgE KW - IgG KW - immune response KW - immunity KW - immunoglobulins KW - laboratory animals KW - nitric oxide KW - parasites KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - gamma-globulins KW - immune globulins KW - immunity reactions KW - immunological reactions KW - inducible nitric oxide synthase KW - nitric oxide synthase KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Strigeida KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804117&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region. AU - Mei, Q. AU - Turner, R. E. AU - Sorial, V. AU - Klivington, D. AU - Angus, C. W. AU - Kovacs, J. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 9 SP - 4268 EP - 4273 SN - 0019-9567 AD - Mei, Q.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202585. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Seven major surface glycoprotein (MSG) genes were cloned from a single human isolate of P. carinii by PCR or genomic library screening and were sequenced. The predicted proteins, like rat MSGs, were closely related but unique variants, with a high level of conservation among cysteine residues. A conserved immunodominant region (of approx. 100 amino acids) near the carboxy terminus was expressed at high levels in Escherichia coli and used in Western blot studies. All 49 of the serum samples, which were taken from healthy controls as well as from patients with and without P. carinii pneumonia, were reactive with this peptide by Western blotting, supporting the hypothesis that most adult humans have been infected with P. carinii at some point. It is concluded that this recombinant MSG fragment may be a useful reagent for investigating the epidemiology of P. carinii infection in humans. KW - antigens KW - gene expression KW - genes KW - glycoproteins KW - human diseases KW - mycoses KW - pneumocystosis KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - antigenicity KW - fungus KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202585&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii. AU - Yap, G. S. AU - Scharton-Kersten, T. AU - Ferguson, D. J. P. AU - Howe, D. AU - Suzuki, Y. AU - Sher, A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 9 SP - 4382 EP - 4388 SN - 0019-9567 AD - Yap, G. S.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990803339. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology N2 - The virulent RH strain of Toxoplasma gondii is acutely lethal in mice and fails to establish chronic infection. Vaccination of BALB/c mice with a soluble tachyzoite antigen preparation, STAg, in combination with IL-12 results in partial protection against RH lethal challenge. Nevertheless, brain tissue obtained from surviving, vaccinated mice as late as 1 year after RH infection contained latent parasite forms as demonstrated by subinoculation into naive recipients. The tachyzoites arising in the subinoculated animals were genetically indistinguishable from the original RH inoculum. Microscopic examination revealed that the persistent parasite forms present in the brains of vaccinated and challenged mice have a tissue cyst-like morphology and express the bradyzoite antigen BAG-1 but not the tachyzoite-specific antigen SAG-2, and are different from the cysts formed by avirulent T. gondii strains in that the internal parasite stages display ultrastructural features intermediate between tachyzoites and bradyzoites. Moreover, the zoites within the RH tissue cysts are clearly distinct from conventional bradyzoites in their sensitivity to pepsin-HCl digestion. In contrast to the observations made with partially resistant STAg/IL-12-vaccinated animals, no latent forms could be detected in brain tissue after RH challenge of mice immunized with a live attenuated tachyzoite vaccine which confers total protection against this parasite isolate. KW - antigens KW - bradyzoites KW - cytokines KW - experimental infections KW - host parasite relationships KW - immunization KW - interleukin 12 KW - laboratory animals KW - latent infections KW - parasites KW - tachyzoites KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - antigenicity KW - immune sensitization KW - immunogens KW - parasite host relationships KW - soluble tachyzoite antigen KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803339&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages. AU - Doherty, T. M. AU - Sher, A. AU - Vogel, S. N. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1998/// VL - 66 IS - 9 SP - 4553 EP - 4556 SN - 0019-9567 AD - Doherty, T. M.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990803346. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9008-11-1, 10102-43-9, 33069-62-4. Subject Subsets: Protozoology N2 - The antitumour drug paclitaxel (Taxol) has been shown to be a lipopolysaccharide mimetic in murine macrophages. The capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and γ-interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO.)-dependent mechanism. KW - immunology KW - immunostimulation KW - interferon KW - lipopolysaccharides KW - macrophages KW - nitric oxide KW - paclitaxel KW - parasites KW - Leishmania major KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - taxol KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803346&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study. AU - Forman, M. R. AU - Johnson, E. J. AU - Lanza, E. AU - Graubard, B. I. AU - Beecher, G. R. AU - Muesing, R. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1998/// VL - 67 IS - 1 SP - 81 EP - 87 SN - 0002-9165 AD - Forman, M. R.: Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19981404299. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 432-70-2, 7488-99-5, 7235-40-7, 502-65-8, 127-40-2, 144-68-3. Subject Subsets: Human Nutrition N2 - As premenopausal women experience cyclic fluctuations of plasma carotenoids and their lipoprotein carriers, it was hypothesized that carotenoid concentrations in lipoprotein fractions fluctuate by phase of the menstrual cycle. Nine women ate a standard set of carotenoid-rich foods daily for 2 cycles under isoenergetic conditions. In the second cycle, hormones and carotenoids in lipoprotein fractions were measured in the early and late follicular and luteal phases. α-Carotene concentrations in the LDL fraction were lower in the early than in the late follicular phase (P=0.03) on the basis of regression analysis. β-Carotene concentrations in the LDL fraction and the HDL2 subfraction were higher in the late follicular than in the luteal phase (P=0.02 and P=0.04, respectively). Lutein [xanthophyll]/zeaxanthin concentrations in the LDL and HDL fractions were higher in the late follicular than in the luteal phase (P=0.03 and P=0.02, respectively). In each phase, 80% of α-carotene, 82% of β-carotene, 85% of lycopene and 64% of lutein/zeaxanthin were distributed in the LDL fraction. Among the hydrocarbon carotenoids, 18% of α-carotene and of β-carotene and 13% of lycopene were distributed in the HDL fraction, with slightly more in the HDL2 than in the HDL3 subfraction. In contrast 34% of lutein/zeaxanthin was distributed in the HDL fraction with more concentrated in the HDL3 than in the HDL2 subfraction. Less than 4% of any carotenoid was found in the VLDL+IDL (intermediate-density-lipoprotein) fractions. Thus, the hydrocarbon carotenoids were highly concentrated in the LDL fraction and xanthophyll was more evenly distributed in the LDL and HDL fractions. It was concluded that the cyclic fluctuations of these carotenoids in lipoprotein fractions add another dimension to the understanding of their transport and physiologic function. KW - alpha-carotene KW - beta-carotene KW - blood KW - carotenoids KW - diet KW - high density lipoprotein KW - lipoproteins KW - low density lipoprotein KW - lycopene KW - menstrual cycle KW - nutritional state KW - very low density lipoprotein KW - vitamins KW - women KW - xanthophyll KW - zeaxanthin KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - lutein KW - nutritional status KW - tetraterpenoids KW - Human Reproduction and Development (VV060) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404299&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. AU - Visser, M. AU - Langlois, J. AU - Guralnik, J. M. AU - Cauley, J. A. AU - Kronmal, R. A. AU - Robbins, J. AU - Williamson, J. D. AU - Harris, T. B. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1998/// VL - 68 IS - 3 SP - 584 EP - 590 SN - 0002-9165 AD - Visser, M.: National Institute on Aging, Epidemiology, Demography, and Biometry Program, Gateway Building, Room 3C309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA. N1 - Accession Number: 19981416487. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - The relation between body composition (fat mass and fat-free mass, assessed by bioelectrical impedance) and self-reported, mobility-related disability (difficulty walking or stair climbing) was studied in 2714 women and 2095 men aged 65-100 years. Data from the Cardiovascular Health Study was used: an ongoing population based, observational study of 5201 older men and women in California, Maryland, Pennsylvania and North Carolina, USA. In a cross-sectional analysis at baseline (1989-1990), disability was reported by 26.5% of women and 16.9% of men. A positive association was observed between fat mass and disability. The odds ratio for disability in the highest quintile of fat mass was 3.04 (95% CI: 2.18, 4.25) for women and 2.77 (95% CI: 1.82, 4.23) for men compared with those in the lowest quintile. Low fat-free mass was not associated with a higher prevalence of disability. In a longitudinal analysis among persons not reporting disability at baseline, 20.3% of the women and 14.8% of the men reported disability 3 years later. Fat mass at baseline was predictive of disability 3 years later, with odds ratios of 2.83 (95% CI: 1.80, 4.46) for women and 1.72 (95% CI: 1.03, 2.85) for men in the highest quintile of fat. The increased risk was not explained by age, physical activity, chronic disease or other potential confounders. Low fat-free mass was not predictive of disability. It is concluded that a high body fat is an independent predictor of mobility-related disability in older men and women. KW - anthropometric dimensions KW - body composition KW - body fat KW - body lean mass KW - disabilities KW - elderly KW - health KW - men KW - obesity KW - old age KW - risk factors KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aged KW - anthropometric measurements KW - elderly people KW - fatness KW - lean body mass KW - older adults KW - senior citizens KW - United States of America KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416487&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. AU - Pise-Masison, C. A. AU - Choi KyeongSook AU - Radonovich, M. AU - Dittmer, J. AU - Kim SeongJin AU - Brady, J. N. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 2 SP - 1165 EP - 1170 SN - 0022-538X AD - Pise-Masison, C. A.: Laboratory of Receptor Biology and Gene Expression, Division of Basic Sciences, National Cancer Institute, 41 Library Dr., 41/B403, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003053. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - These studies were initiated to analyse whether the stabilized wild-type p53 in HTLV-I-transformed cell lines was transcriptionally active. Data obtained from transfection experiments using a p53-responsive reporter plasmid and from γ-irradiation studies demonstrate that the wild-type p53 in these cell lines is not fully active. Further, it is demonstrated that Tax alone in contransfection studies is capable of inactivating p53 by inhibiting the N-terminal p53 activation domain. KW - cell lines KW - genes KW - growth KW - human diseases KW - pathogenesis KW - regulation KW - T lymphocytes KW - Tax protein KW - transactivation KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - viruses KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - T cells KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003053&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The application of a homologous recombination assay revealed amino acid resides in an LTR-retrotransposon that were critical for integration. AU - Atwood, A. AU - Choi, J. AU - Levin, H. L. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 2 SP - 1324 EP - 1333 SN - 0022-538X AD - Atwood, A.: Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982003058. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 9007-49-2. N2 - Retroviruses and their relatives, the LTR-retrotransposons, possess an integrase protein (IN) that is required for the insertion of reverse transcripts into the genome of host cells. Schizosaccharomyces pombe is the host of Tfl, an LTR-retrotransposon with integration activity that can be studied by using techniques of yeast genetics. The purpose of this study was to identify amino acid substitutions in Tfl that specifically affected the integration step of transposition. In addition to seeking amino acid substitutions in IN, the possibility was also explored that other Tfl proteins contributed to integration. By comparing the results of genetic assays that monitored both transposition and reverse transcription, it was possible to seek point mutations throughout Tfl that blocked transposition but not the synthesis of reverse transcripts. These mutant versions of Tfl were candidates of elements that possessed defects in the integration step of transposition. Five mutations in Tfl that resulted in low levels of integration were found to be located in the IN protein: two substitutions in the N-terminal Zn domain, two in the catalytic core, and one in the C-terminal domain. These results suggested that each of the three IN domains was required for Tfl transposition. The potential role of these 5 amino acid residues in the function of IN is discussed. KW - amino acids KW - DNA KW - genomes KW - hosts KW - integration KW - mutations KW - pathogenesis KW - proteins KW - recombination KW - residues KW - reverse transcription KW - ribonucleases KW - synthesis KW - techniques KW - transposition KW - yeasts KW - fungi KW - eukaryotes KW - deoxyribonucleic acid KW - fungus KW - gene transposition KW - genetic recombination KW - integrase KW - RNASE KW - RNase H KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic determinants responsible for acquisition of dengue type 2 virus mouse neurovirulence. AU - Bray, M. AU - Men, R. AU - Tokimatsu, I. AU - Lai ChingJuh JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 2 SP - 1647 EP - 1651 SN - 0022-538X AD - Bray, M.: Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19980503811. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Studies conducted some 50 years ago showed that serial intracerebral passage of dengue viruses in mice selected for neurovirulent mutants that also exhibited significant attenuation for humans. The genetic basis of mouse neurovirulence of dengue virus was investigated as it might be directly or indirectly associated with attenuation for humans. Analysis of the sequence in the C-PreM-E-NS1 region of the parental dengue type 2 virus (DEN2) New Guinea C (NGC) strain and its mouse-adapted, neurovirulent mutant revealed that 10 nucleotide changes occurred during serial passage in mice. 7 of these changes resulted in amino acid substitutions, i.e. Leu55-Phe and Arg57-Lys in PreM, Glu71-Asp, Glu126-Lys, Phe402-Ile, and Thr454-Ile in E, and Arg105-Gln in NS1. The sequence of C was fully conserved between the parental and mutant DEN2. Intertypic chimaeric dengue viruses were constructed that contained the PreM-E genes or only the NS1 gene of neurovirulent DEN2 NGC substituting for the corresponding genes of DEN4. The DEN2 (PreM-E)/DEN4 chimaera was neurovirulent for mice, whereas DEN2 (NS1)/DEN4 was not. The mutations present in the neurovirulent DEN2 PreM-E genes were then substituted singly or in combination into the sequence of the nonneurovirulent, parental DEN2. Intracerebral titration of the various mutant chimaeras so produced identified 2 amino acid changes, namely, Glu71-Asp and Glu126-Lys, in DEN2 E as being responsible for mouse neurovirulence. The conservative amino acid change of Glu71-Asp probably had a minor effect, if any. The Glu126-Lys substitution in DEN2 E, representing a change from a negatively charged amino acid to a positively charged amino acid, most probably plays an important role in conferring mouse neurovirulence. KW - acquisition KW - amino acids KW - arboviruses KW - chimaeras KW - genetics KW - virulence KW - dengue 2 virus KW - dengue virus KW - mice KW - Dengue virus KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - chimeras KW - neurovirulence KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980503811&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1. AU - Moriuchi, H. AU - Moriuchi, M. AU - Fauci, A. S. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 4 SP - 3394 EP - 3400 SN - 0022-538X AD - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, BLDG 10, Rm 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982005750. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 302-79-4. N2 - Although promonocytic cell lines such as U937 have been used as in vitro models of HIV-1 infection of monocyte-macrophages (M/M), these cell lines are susceptible to certain T-cell-tropic (T-tropic) HIV-1 strains but are resistant to M-tropic HIV-1. This study demonstrates that (i) certain U937 clones ("plus" clones), which are susceptible only to T-tropic HIV-1, become highly susceptible to M-tropic HIV-1 upon differentiation with retinoic acid (RA); (ii) other U937 clones ("minus" clones), which are resistant to both T- and M-tropic HIV-1, remain resistant to both viruses; and (iii) RA treatment induces expression of CCR5, a fusion/entry cofactor for M-tropic HIV-1 in both types of U937 clones, and yet enhances the fusogenicity of the plus clones, but not the minus clones, with M-tropic Envs. These results indicate that the major restriction of M-tropic HIV-1 infection in promonocytic cells occurs at the fusion/entry level, that differentiation into macrophage-like phenotypes renders some of these cells highly susceptible to infection with M-tropic HIV-1, and that CD4 and CCR5 may not be the only determinants of fusion/entry of M-tropic HIV-1 in these cells. KW - cell fusion KW - cofactors KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - pathogenesis KW - phenotypes KW - retinoic acid KW - T lymphocytes KW - tropisms KW - uptake KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - tretinoin KW - vitamin A acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005750&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251: dependence on route of challenge exposure. AU - Benson, J. AU - Chougnet, C. AU - Robert-Guroff, M. AU - Montefiori, D. AU - Markham, P. AU - Shearer, G. AU - Gallo, R. C. AU - Cranage, M. AU - Paoletti, E. AU - Limbach, K. AU - Venzon, D. AU - Tartaglia, J. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 5 SP - 4170 EP - 4182 SN - 0022-538X AD - Benson, J.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm. 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982006954. Publication Type: Journal Article. Language: English. Number of References: 50 ref. N2 - The gag, pol, and env genes of SIVK6W were expressed in the NYVAC vector, a genetically engineered derivative of the vaccinia virus Copenhagen strain that displays a highly attenuated phenotype in humans. In addition, the genes for the α and β chains of interleukin-12 (IL-12), as well as the IL-2 gene, were expressed in separate NYVAC vectors and inoculated intramuscularly, in conjunction with or separate from the NYVAC-SIV vaccine, in 40 macaques. The overall cytotoxic T-lymphocyte (CTL) response was greater, at the expense of proliferative and humoral responses, in animals immunized with NYVAC-SIV and NYVAC-IL-12 than in animals immunized with the NYVAC-SIV vaccine alone. At the end of the immunization regimen, half of the animals were challenged with SIVmac251 by the intravenous route and the other half were exposed to SIVmac251 intrarectally. Significantly, 5 of the 11 vaccinees exposed mucosally to SIVmac251 showed a transient peak of viraemia 1 week after viral challenge and subsequently appeared to clear viral infection. In contrast, all 12 animals inoculated intravenously became infected, but 5 to 6 months after viral challenge, 4 animals were able to control viral expression and appeared to progress to disease more slowly than control animals. Protection did not appear to be associated with any of the measured immunological parameters. Further modulation of immune responses by coadministration of NYVAC-cytokine recombinants did not appear to influence the outcome of viral challenge. The fact that the NYVAC-SIV recombinant vaccine appears to be effective per se in the animal model that best mirrors human AIDS supports the idea that the development of a highly attenuated poxvirus-based vaccine candidate can be a valuable approach to decrease significantly the spread of HIV infection by the mucosal route. KW - acquired immune deficiency syndrome KW - animal models KW - cytotoxicity KW - disease vectors KW - genes KW - HIV infections KW - human immunodeficiency viruses KW - humoral immunity KW - immune response KW - immunization KW - infection KW - infections KW - live vaccines KW - mucosa KW - pathogenicity KW - phenotypes KW - regimens KW - responses KW - T lymphocytes KW - vaccines KW - vectors KW - viral diseases KW - Macaca KW - man KW - monkeys KW - simian immunodeficiency virus KW - vaccinia virus KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - AIDS KW - attenuated vaccines KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - mucous membrane KW - T cells KW - vaccine candidates KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006954&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2pan-p) transform T cells independently of Jak/STAT activation. AU - Mulloy, J. C. AU - Migone, T. S. AU - Ross, T. M. AU - Ton, N. AU - Green, P. L. AU - Leonard, W. J. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 5 SP - 4408 EP - 4412 SN - 0022-538X AD - Mulloy, J. C.: Basic Research Laboratory, Bldg. 37, Rm 6A09, National Cancer Institute, NIH, 37 Convent Dr., MSC 4255, Bethesda, MD 20892-8394, USA. N1 - Accession Number: 19982006934. Publication Type: Journal Article. Language: English. Number of References: 41 ref. KW - lymphocyte transformation KW - pathogenesis KW - T lymphocytes KW - Deltaretrovirus KW - human T-cell lymphotropic virus type II KW - monkeys KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - simian T-lymphotropic virus type II KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006934&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates. AU - Bazan, H. A. AU - Alkhatib, G. AU - Broder, C. C. AU - Berger, E. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 5 SP - 4485 EP - 4491 SN - 0022-538X AD - Bazan, H. A.: Bldg 4, Rm 236, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982006939. Publication Type: Journal Article. Language: English. Number of References: 99 ref. N2 - Coreceptor usage by Envs from diverse primary HIV-1 isolates was analysed by a vaccinia virus-based expression and assay system. Usage of recombinant CCR5 and CXCR4 correlated closely with fusogenicity toward macrophages and T-cell lines expressing endogenous coreceptors. Recombinant CCR3 was utilized by most primary and T-cell-line-adapted Envs. Endogenous CXCR4 in macrophages was functional as a coreceptor. KW - chemokines KW - cytokines KW - envelope glycoproteins KW - glycoproteins KW - human diseases KW - human immunodeficiency viruses KW - macrophages KW - receptors KW - T lymphocytes KW - uptake KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006939&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5Δ32. AU - Michael, N. L. AU - Nelson, J. E. A. AU - Kewalramani, V. N. AU - Chang, G. AU - O'Brien, S. J. AU - Mascola, J. R. AU - Volsky, B. AU - Louder, M. AU - White, G. C. II AU - Littman, D. R. AU - Swanstrom, R. AU - O'Brien, T. R. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 7 SP - 6040 EP - 6047 SN - 0022-538X AD - Michael, N. L.: Viral Epidemiology Branch, National Cancer Institute, NIH, EPN 434, 6130 Executive Blvd., Rockville, MD 20852, USA. N1 - Accession Number: 19982009731. Publication Type: Journal Article. Language: English. Number of References: 60 ref. N2 - Individuals who are homozygous for the 32-bp deletion in the gene coding for the chemokine receptor and major HIV-1 coreceptor CCR5 (CCR5 -/-) lack functional cell surface CCR5 molecules and are relatively resistant to HIV-1 infection. HIV-1 infection in CCR5 -/- individuals although rare, has been increasingly documented. This report shows that the viral quasispecies from one such individual throughout disease is homogenous, T-cell line tropic, and phenotypically syncytium-inducing (SI); exclusively uses CXCR4; and replicates well in CCR5 -/- primary T cells. The recently discovered coreceptors BOB and Bonzo are not used. Although early and persistent SI variants have been described in longitudinal studies, this is the first demonstration of exclusive and persistent CXCR4 usage. With the caveat that the earliest viruses available from this subject were from ~4 years following primary infection, these data suggest that HIV-1 infection can be mediated and persistently maintained by viruses which exclusively utilize CXCR4. The lack of evolution toward the available minor coreceptors in this subject underscores the dominant biological roles of the major coreceptors CCR5 and CXCR4. KW - chemokines KW - cytokines KW - homozygosity KW - human diseases KW - pathogenesis KW - receptors KW - syncytia KW - tropisms KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009731&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CXCR4 and CCR5 genetic polymorophisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR4-Δ32. AU - Cohen, O. J. AU - Paolucci, S. AU - Bende, S. M. AU - Daucher, M. AU - Moriuchi, H. AU - Mouiuchi, M. AU - Cicala, C. AU - Devey, R. T. Jr. AU - Baird, B. AU - Fauci, A. S. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 7 SP - 6215 EP - 6217 SN - 0022-538X AD - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, 10 Center Dr., MSC 1876, Gldg. 10, RM. 11B13, Bethesda, MD 20892-1876, USA. N1 - Accession Number: 19982009724. Publication Type: Journal Article. Language: English. Number of References: 27 ref. N2 - Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of HIV-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to 2 nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals. KW - chemokines KW - cytokines KW - disease course KW - human diseases KW - human immunodeficiency viruses KW - mutations KW - pathogenesis KW - polymorphism KW - receptors KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - human immunodeficiency virus KW - non-progressors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009724&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. AU - Pise-Masison, C. A. AU - Radonovich M. AU - Sakaguchi, K. AU - Appella, E. AU - Brady, J. N. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 8 SP - 6348 EP - 6355 SN - 0022-538X AD - Pise-Masison, C. A.: Virus Tumor Biology Section, Laboratory of Receptor Biology and Gene Expression, Bldg. 41/B403, National Cancer Institute, NIH, Bethesda, MD 20892-5055, USA. N1 - Accession Number: 19982011038. Publication Type: Journal Article. Language: English. Number of References: 52 ref. KW - adult T-cell leukaemia KW - human diseases KW - inactivation KW - pathogenesis KW - proteins KW - T lymphocytes KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - adult T-cell leukemia KW - HTLV-BLV group KW - oncogenesis KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011038&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms. AU - Dittmer, U. AU - Brooks, D. M. AU - Hasenkrug, K. J. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 8 SP - 6554 EP - 6558 SN - 0022-538X AD - Dittmer, U.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH 903 S. 4th St., Hamilton, MT 59840, USA. N1 - Accession Number: 19982010962. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - Live-attenuated retroviruses have been shown to be effective retroviral vaccines, but currently little is known regarding the mechanism of protection. In this study Friend murine leukaemia virus (F-MuLv) was used as a model to analyse characteristics of a live-attenuated vaccine in protection against virus-induced disease. Live vaccine virus was found to be necessary for induction of immunity, since inactivated F-MuLV did not induce protection. KW - animal models KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunity KW - live vaccines KW - vaccines KW - mice KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - attenuated vaccines KW - Friend murine leukaemia virus KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Critical role for CD4+ T cells in controlling retrovirus replication and spread in persistently infected mice. AU - Hasenkrug, K. J. AU - Brooks, D. M. AU - Dittmer, U. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 8 SP - 6559 EP - 6564 SN - 0022-538X AD - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH 903 S. 4th St., Hamilton, MT 59840, USA. N1 - Accession Number: 19982010963. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - This report shows that the primary reservoir for persistent Friend virus complex infection in the spleen is a small subset of B cells. In at least half of the mice, replication of virus and spread to other cell types are shown to be controlled by a subpopulation of T cells. KW - acquired immune deficiency syndrome KW - animal models KW - B lymphocytes KW - CD4+ lymphocytes KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - leukaemia KW - replication KW - T lymphocytes KW - viral replication KW - mice KW - Retroviridae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - B cells KW - blood cancer KW - CD4+ cells KW - Friend murine leukaemia virus KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - leucaemia KW - leukemia KW - T cells KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010963&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies. AU - Ostrowski, M. A. AU - Krakauer, D. C. AU - Li YueXia AU - Justement, S. J. AU - Learn, G. AU - Ehler, L. A. AU - Stanley, S. K. AU - Nowak, M. AU - Fauci, A. S. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 10 SP - 7772 EP - 7784 SN - 0022-538X AD - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg. 10, Rm. 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982013917. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - This study defines the viral genetic basis for the transient bursts in viraemia after immune activation. Tetanus immunization was associated with dramatic and generally reversible shifts in the composition of plasma viral quasispecies. The viral bursts in most cases reflected a nonspecific increase in viral replication secondary to an expanded pool of susceptible CD4+ T cells. An exception to this was in a patient who harboured viruses of differing tropisms (syncytium inducing and non-syncytium inducing [NSI]). In this situation, immunization appeared to select for the replication of NSI viruses. In 1 of 3 patients, the data suggested that immune activation resulted in the appearance in plasma of virus induced from latently infected cells. These findings illustrate certain mechanisms whereby antigenic stimulation may influence the dynamics of HIV replication, including the relative expression of different viral variants. KW - blood plasma KW - dynamics KW - genetic variation KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunization KW - pathogenesis KW - phenotypes KW - replication KW - stimulation KW - syncytia KW - T lymphocytes KW - tetanus KW - tropisms KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - genetic variability KW - genotypic variability KW - genotypic variation KW - human immunodeficiency virus KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - lockjaw KW - plasma (blood) KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013917&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. AU - Rossio, J. L. AU - Esser, M. T. AU - Suryanarayana, K. AU - Schneider, D. K. AU - Bess, J. W. Jr. AU - Vasquez, G. M. AU - Wiltrout, T. A. AU - Chertova, E. AU - Grimes, M. K. AU - Sattentau, Q. AU - Arthur, L. O. AU - Henderson, L. E. AU - Lifson, J. D. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 10 SP - 7992 EP - 8001 SN - 0022-538X AD - Rossio, J. L.: Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Bldg 535, Rm 510, Frederick, MD 21702, USA. N1 - Accession Number: 19982013928. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 50-00-0, 7440-66-6. N2 - HIV-1 virions whose infectivity was abrogated were examined by the use of prototypical nucleocapsid zinc finger targeting compound, 2,2′-dithiopyridine (aldrithiol-2 [AT-2]). The analysis focused on assays intended to assess the conformational and functional integrity of virion surface proteins, comparing AT-2-inactivated virus to native virus and to virions inactivated by classical means such as heat treatment or formaldehyde fixation. The findings indicate that the surface proteins of AT-2-treated virus are conformationally and functionally intact, but the virions are not infectious, with the block to infectivity occurring after virion binding and membrane fusion but before reverse transcription. KW - antigens KW - antiviral properties KW - conformation KW - formaldehyde KW - heat treatment KW - human diseases KW - human immunodeficiency viruses KW - inactivation KW - infectivity KW - nucleocapsid proteins KW - proteins KW - structure KW - surface proteins KW - transcription KW - treatment KW - vaccines KW - zinc KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - antigenicity KW - body conformation KW - DNA transcription KW - heat processing KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunogens KW - membrane proteins KW - virions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013928&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89.6 envelope protein. AU - Belyakov, I. M. AU - Wyatt, L. S. AU - Ahlers, J. D. AU - Earl, P. AU - Pendleton, C. D. AU - Kelsall, B. L. AU - Strober, W. AU - Moss, B. AU - Berzofsky, J. A. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 10 SP - 8264 EP - 8272 SN - 0022-538X AD - Belyakov, I. M.: Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Bldg 10, Rm 6B-12 (MSC #1578), NIH, Bethesda, MD 20892-1578, USA. N1 - Accession Number: 19982013935. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 308079-78-9. N2 - To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. In this study, MVA was applied to HIV-1 vaccine development by incorporating the envelope protein gp160 of HIV-1 primary isolate strain 89.6 (MVA 89.6) and using it to induce mucosal cytotoxic-T-lymphocyte (CTL) immunity. Once the CTL specificity was defined, BALB/c mice were immunized intrarectally with recombinant MVA 89.6. A single mucosal immunization with MVA 89.6 elicited long-lasting antigen-specific mucosal (Peyer's patch and lamina propria) and systemic (spleen) CTL responses as effective as or more effective than those of a replication-competent vaccinia virus expressing 98.6 gp160. Immunization with MVA89.6 led to (i) the loading of antigen-presenting cells in vivo, as measured by the ex vivo active presentation of the P18-89.6 peptide to an antigen-specific CTL line, and (ii) the significant production of the proinflammatory cytokines (interleukin-6 and tumour necrosis factor alpha) in the mucosal sites. These results indicate that nonreplicating recombinant MVA may be at least as effective for mucosal immunization as replicating recombinant vaccinia virus. KW - cytokines KW - cytotoxicity KW - development KW - envelope protein gp160 KW - envelope proteins KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunity KW - immunization KW - interleukin 6 KW - modification KW - mucosa KW - necrosis KW - replication KW - safety KW - spleen KW - T lymphocytes KW - tumour necrosis factor KW - vaccines KW - Human immunodeficiency virus 1 KW - man KW - mice KW - vaccinia virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - cachectin KW - cachexin KW - gp160 KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - mucous membrane KW - T cells KW - tumor necrosis factor KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain. AU - Mulloy, J. C. AU - Kislyakova, T. AU - Cereseto, A. AU - Casereto, L. AU - LoMonico, A. AU - Fullen, J. AU - Lorenzi, M. V. AU - Cara, A. AU - Nicot, C. AU - Giam, C. Z. AU - Franchini, G. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 11 SP - 8852 EP - 8860 SN - 0022-538X AD - Mulloy, J. C.: Basic Research Laboratory, National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm 6A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014310. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - Transient coexpression of p53 and Tax resulted in the suppression of p53 transcriptional activity. Expression of Tax abrogated p53-induced G1 arrest in the Calu-6 cell line and prevented the apoptosis induced by overexpressing p53 in the HeLa/Tat cell line. KW - apoptosis KW - cell cycle KW - genes KW - human diseases KW - pathogenesis KW - Tax protein KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014310&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. AU - Mochizuki, H. AU - Schwartz, J. P. AU - Tanaka, K. AU - Brady, R. O. AU - Reiser, J. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 11 SP - 8873 EP - 8883 SN - 0022-538X AD - Mochizuki, H.: National Institutes of Health, Bldg 10, Rm 3D04, 10 Center Dr., MSC 1260, Bethesda, MD 20892-1260, USA. N1 - Accession Number: 19982014311. Publication Type: Journal Article. Language: English. Number of References: 65 ref. KW - gene therapy KW - human diseases KW - vectors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014311&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. AU - Meng XiangJin AU - Halbur, P. G. AU - Shapiro, M. S. AU - Sugantha Govindarajan AU - Bruna, J. D. AU - Mushahwar, I. K. AU - Purcell, R. H. AU - Emerson, S. U. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 12 SP - 9714 EP - 9721 SN - 0022-538X AD - Meng XiangJin: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992200277. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science N2 - The infectivity titre of a pool of swine hepatitis E virus (HEV) in pigs was measured to prepare a standardized reagent and to evaluate the dose response in pigs. Although the sequence of swine HEV varied extensively from those of most human strains of HEV, it was very closely related to the 2 strains of human HEV (US-1 and US-2) isolated in the United States. The US strains which were recently recovered from 2 patients with clinical hepatitis E in the United States shared ≥97% amino acid identity with swine HEV in open reading frames 1 and 2. Phylogenetic analyses of different regions of the genome showed that swine HEV and the US strains grouped together and formed a distinct branch. These results suggested that swine HEV may infect man. Rhesus monkeys and a chimpanzee, inoculated with swine HEV became infected. Furthermore, in a reciprocal experiment, SPF pigs were experimentally infected with the US-2 strain of human HEV that is genetically similar to swine HEV. These results provided experimental evidence for cross-species infection by the swine virus. Thus, man appears to be at risk of infection with swine HEV or closely related viruses. KW - experimental infection KW - strain differences KW - zoonoses KW - USA KW - Hepadnaviridae KW - hepatitis E virus KW - man KW - pigs KW - DNA Reverse Transcribing Viruses KW - viruses KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sus scrofa KW - Sus KW - Suidae KW - Suiformes KW - Artiodactyla KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - experimental transmission KW - hogs KW - swine KW - United States of America KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992200277&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. AU - Monaco, M. C. G. AU - Jensen, P. N. AU - Hou, J. AU - Durham, L. C. AU - Major, E. O. JO - Journal of Virology JF - Journal of Virology Y1 - 1998/// VL - 72 IS - 12 SP - 9918 EP - 9923 SN - 0022-538X AD - Monaco, M. C. G.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA. N1 - Accession Number: 19992001629. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health N2 - To determine whether tonsils harbour JC virus (JCV), 54 tonsils - 38 from children and 16 from adult donors - were tested for JCV DNA using nested PCRs with primer sets specific for the viral T protein and regulatory regions. JCV DNA was detected in 21 of 54 tonsil tissues, or 39% (15 of 38 children and 6 of 16 adults) by using regulatory-region primers and in 19 of 54 tonsil tissues, or 35% (13 of 38 children and 6 of 16 adults) by using the T-protein primers. The DNA extracted from children's non-dissected tonsil tissue, isolated tonsillar lymphocytes, and isolated stromal cells that demonstrated PCR amplification of the JCV regulatory region underwent cloning and nucleotide sequencing. Of the regulatory-region sequences obtained, nearly all contained tandem repeat arrangements. Clones originating from non-dissected tonsil tissue and tonsillar lymphocytes were found to have sequences predominantly of the Mad-1 prototype strain, whereas the majority of clones from the DNA of tonsillar stromal cells had sequences characteristic of the Mad-8br strain of JCV. A few clones demonstrated structures other than tandem repeats but were isolated only from tonsillar lymphocytes. It is concluded that these data provide the first evidence of the JCV genome in tonsil tissue and suggest that tonsils may serve as an initial site of viral infection. KW - adults KW - children KW - detection KW - DNA KW - human diseases KW - pathology KW - progressive multifocal leukoencephalopathy KW - tonsils KW - JC polyomavirus KW - man KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - deoxyribonucleic acid KW - JC virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001629&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rising incidence of biliary tract cancers in Shanghai, China. AU - Hsing, A. W. AU - Gao YuTang AU - Devesa, S. S. AU - Jin, F. AU - Fraumeni, J. F., Jr. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1998/// VL - 75 IS - 3 SP - 368 EP - 370 SN - 0020-7136 AD - Hsing, A. W.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992005740. Publication Type: Journal Article. Language: English. Number of References: 15 ref. N2 - During 1972-1994, biliary tract cancer was the most rapidly rising malignancy in Shanghai, China, with a 119% increase in men and 124% in women. The increase in incidence was seen for all 3 subsites, both sexes, and all age groups. KW - biliary system KW - epidemiology KW - human diseases KW - incidence KW - malignant course KW - men KW - neoplasms KW - women KW - China KW - Shanghai KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Eastern China KW - China KW - cancers KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005740&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary habits and stomach cancer in Shanghai, China. AU - Ji BuTian AU - Chow WongHo AU - Yang Gong AU - McLaughlin, J. K. AU - Zheng Wei AU - Shu XiaoOu AU - Jin Fan AU - Gao RuNie AU - Gao YuTang AU - Fraumeni, J. F., Jr. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1998/// VL - 76 IS - 5 SP - 659 EP - 664 SN - 0020-7136 AD - Ji BuTian: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981416991. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - To clarify risk factors for stomach cancer a population-based case-control study was conducted in Shanghai, China. 1124 stomach cancer patients (20-69 years old) who were newly diagnosed between 1988 and 1989 and 1451 controls randomly selected from among Shanghai residents were recruited. Usual adult dietary intake was assessed using a comprehensive food frequency questionnaire. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models. Risks of stomach cancer were inversely associated with high consumption of several food groups, including fresh vegetables and fruits, poultry, eggs, plant oil and some nutrients, such as protein, fat, fibre and antioxidant vitamins. By contrast, risks increased with increasing consumption of dietary carbohydrates, with OR of 1.5 (95% CI 1.1-2.1) and 1.9 (95% CI 1.3-2.9) in the highest quartile of intake among men (P=0.02) and women (P=0.0007), respectively. Similar increases in risk were associated with frequent intake of noodles and bread in men (P=0.07) and women (P=0.05) after further adjustment for fibre consumption. In addition, increased risks were associated with frequent consumption of preserved, salty or fried foods and hot soup/porridge and with irregular meals, speed eating and binge eating. No major differences in risk were seen according to subsite (cardia vs. non-cardia). It was concluded that these results suggest that diet plays a major role in stomach cancer risk. KW - antioxidants KW - carbohydrates KW - diet KW - diet studies KW - eggs KW - fat KW - feeding habits KW - fibre KW - fruit KW - neoplasms KW - plant oils KW - poultry meat KW - protein KW - risk KW - risk factors KW - stomach KW - vegetables KW - vitamins KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - eating habits KW - fiber KW - People's Republic of China KW - saccharides KW - vegetable crops KW - vegetable oils KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416991&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for colorectal cancer in a prospective study among U.S. white men. AU - Hsing, A. W. AU - McLaughlin, J. K. AU - Chow WongHo AU - Schuman, L. M. AU - Co Chien, H. T. AU - Gridley, G. AU - Bjelke, E. AU - Wacholder, S. AU - Blot, W. J. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1998/// VL - 77 IS - 4 SP - 549 EP - 553 SN - 0020-7136 AD - Hsing, A. W.: Division of Cancer Epidmeiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19991400203. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition N2 - Associations of diet, smoking/drinking and occupation with subsequent risk of fatal colorectal cancer was examined in a cohort of 17 633 white men from the USA aged 35 and older, who completed a postal questionnaire in 1966. During the subsequent 20 years of follow-up, 120 colon cancer and 25 rectal cancer deaths were identified. Due to small numbers, no significant dose-response trends were observed in the study, but the risk of colon cancer was increased among heavy cigarette smokers (≥30/day; relative risk (RR) = 2.3, 95% confidence interval (CI) 0.9-5.7), heavy beer drinkers (≥14 times/month; RR = 1.9, 95% CI 1.0-3.8) and white-collar workers (RR = 1.7, 95% CI 1.0-3.0) or crafts workers within service and trade industries (RR = 2.6, 95% CI 1.1-5.8). In addition, an increased risk was seen for those who consumed red meat more than twice a day (RR = 1.8, 95% CI 0.8-4.4). Risk patterns for cancers of the colon and rectum combined were similar to those reported for cancer of the colon, but the estimates were somewhat dampened. It was concluded that a high intake of red meat and a sedentary life-style may increase the risk of colon cancer. KW - alcoholic beverages KW - colon KW - diet KW - meat KW - men KW - neoplasms KW - occupations KW - physical activity KW - rectum KW - risk KW - risk factors KW - tobacco smoking KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400203&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Aspergillus nidulans infection in chronic granulomatous disease. AU - Segal, B. H. AU - DeCarlo, E. S. AU - Kwon-Chung, K. J. AU - Malech, H. L. AU - Gallin, J. I. AU - Holland, S. M. JO - Medicine (Baltimore) JF - Medicine (Baltimore) Y1 - 1998/// VL - 77 IS - 5 SP - 345 EP - 354 SN - 0025-7974 AD - Segal, B. H.: Laboratory of Host Defenses and Molecular Microbiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19991202315. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 1397-89-3. N2 - All cases in which A. nidulans was isolated from patients at the National Institutes of Health (Bethesda, MD, USA) during 1976-97 were reviewed. A. nidulans infection occurred in 6 patients with chronic granulomatous disease (CGD), but was not a pathogen in any other patient group. Aspergillus fumigatus was a more common pathogen in CGD compared with A. nidulans, but A. nidulans was more virulent. A. nidulans was significantly more likely to result in death compared with A. fumigatus, to involve adjacent bone and to cause disseminated disease. Patients with A. nidulans received longer courses of amphotericin B therapy than patients with A. fumigatus, and were treated with surgery more often. In contrast to A. fumigatus, A. nidulans was generally refractory to intensive antifungal therapy, suggesting that early surgery may be important. It is concluded that A. nidulans is a distinct pathogen in CGD and its isolation carries more severe implications than that of A. fumigatus. KW - amphotericin B KW - antifungal agents KW - aspergillosis KW - epidemiology KW - generalized infections KW - human diseases KW - infections KW - pathogenicity KW - prognosis KW - surgery KW - virulence KW - USA KW - Aspergillus fumigatus KW - Emericella nidulans KW - man KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Emericella KW - Aspergillus nidulans KW - chronic granulomatous disease KW - fungistats KW - fungus KW - Hyphomycetes KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202315&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of human herpesvirus-8 oncogene and cytokine homologues in an HIV-seronegative patient with multicentric Castleman's disease and primary effusion lymphoma. AU - Teruya-Feldstein, J. AU - Zauber, P. AU - Setsuda, J. E. AU - Berman, E. L. AU - Sorbara, L. AU - Raffeld, M. AU - Tosato, G. AU - Jaffe, E. S. JO - Laboratory Investigation JF - Laboratory Investigation Y1 - 1998/// VL - 78 IS - 12 SP - 1637 EP - 1642 SN - 0023-6837 AD - Teruya-Feldstein, J.: Laboratory of Pathology, Hematopathology Section, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19992006799. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - A rare case of human herpesvirus-8 (HHV-8) associated multicentric Castleman's disease (MCD), followed by the development of an HHV-8-positive pleural primary effusion lymphoma (PEL) and a gastric large cell lymphoma in an HIV-seronegative male patient is described. The lesions were negative for Epstein-Barr virus (EBV). The combination of these diverse HHV-8-associated lymphoproliferative disorders in a single patient afforded the ability to study potential differences in gene expression in these conditions. HHV-8 DNA was demonstrated by PCR in lymphoid tissues involved by MCD and PEL. By reverse transcriptase-PCR, HHV-8-related transcripts, including vG-coupled protein receptor, vbcl2, vcyclin D, vIL-6, vMIPI, and vMIPII, were detected in the PEL from the pleural cavity and the gastric lymphoma, whereas these transcripts, except for vIL-6, were not detected in a lymph node biopsy with MCD. Expression of hIL-10 was weak in the PEL from the pleural cavity, and expression of hIL-6 was undetectable in all three lesions. These data suggest that vIL-6 may be integral to the pathogenesis of MCD, whereas other viral transcripts that encode oncogene and chemokine homologues are important for HHV-8 tumourigenicity. KW - case reports KW - gene expression KW - human diseases KW - lymphatic diseases KW - lymphoma KW - Herpesviridae KW - human herpesvirus 8 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Rhadinovirus KW - Gammaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Castleman's disease KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006799&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pima Indian males have lower β-adrenergic sensitivity than Caucasian males. AU - Tataranni, P. A. AU - Christin, L. AU - Snitker, S. AU - Paolisso, G. AU - Ravussin, E. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1998/// VL - 83 IS - 4 SP - 1260 EP - 1263 SN - 0021-972X AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19981410551. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - β-Adrenergic sensitivity was examined in 87 nondiabetic normotensive individuals (52 Pima Indians (35 men/17 women) and 35 Caucasians (24 men/11 women)), matched for age and body weight. Chronotropic sensitivity to β-adrenergic stimulation was assessed by the dose of isoproterenol necessary to increase heart rate by 25 beats/min (chronotropic dose-25 (CD25)). Despite a similar basal heart rate and arterial blood pressure, Pimas tended to have lower β-adrenergic sensitivity than Caucasians (CD25 = 2.37±2.27 vs. 1.57±1.38 µg, respectively; P=0.07). This difference was significant in men (CD25 = 3.03±2.39 vs. 1.85±1.56 µg; P=0.02) but not in women (CD25 = 1.01±1.17 vs. 0.96±0.61 µg; P=0.99). In men, CD25 was positively correlated to percentage body fat (r = 0.36, P<0.01). After adjustment for percentage body fat, β-adrenergic sensitivity was still significantly lower in Pima than in Caucasian men (CD25 = 3.44±2.24 vs. 2.57±1.60 µg; P=0.05). It was concluded that increased adiposity is accompanied by decreased β-adrenergic sensitivity in men only. However, at each level of adiposity, Pima Indian men had lower β-adrenergic sensitivity than Caucasian men. In combination with a low sympathetic nervous system activity, a reduced β-adrenergic sensitivity may contribute to the low prevalence of hypertension and the high prevalence of obesity observed in Pima Indians. KW - beta-adrenergic receptors KW - ethnic groups KW - heart rate KW - hypertension KW - men KW - obesity KW - sex differences KW - sympathetic nervous system KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - high blood pressure KW - United States of America KW - Social Structure (UU480) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981410551&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progress in improving diet to reduce cancer risk. AU - Krebs-Smith, S. M. JO - Cancer JF - Cancer Y1 - 1998/// VL - 83 IS - 7 SP - 1425 EP - 1432 SN - 0008-543X AD - Krebs-Smith, S. M.: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19991404620. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition N2 - In an effort to decrease cancer risk among the population, US national health objectives for the year 2000 included recommendations to decrease intake of dietary fat and alcohol and increase intake of fruits, vegetables, and grains. National food supply data and food consumption survey data from 1970-95 were reviewed for their appropriateness for monitoring intake trends. Recent data from both sources are described and interpreted. Americans have made modest but important improvements in their diets in recent years and may meet the "Healthy People 2000" dietary objectives aimed at decreasing cancer risk. Intake of fruits, vegetables, and grains are higher, and those of fat and alcohol are lower than they were at the beginning of the decade. These trends are consistent with recent improvements in mortality rates for those cancer sites with the strongest associations with diet: the colon/rectum, prostate, and breast. Although the average intake of fruits, vegetables, and grain products is higher, it should be noted that the objective represents the minimum recommendations. Within each of these major food groups, further improvements can be made. Special efforts should be made to guide children toward improvements in their diets and to monitor the diets of children and other subgroups. KW - alcoholic beverages KW - breast KW - children KW - colon KW - diet KW - diet studies KW - fats KW - fibre KW - fruit KW - men KW - neoplasms KW - nutrition education KW - nutrition programmes KW - old age KW - prevention KW - prostate KW - rectum KW - vegetables KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - breasts KW - cancers KW - feeding programmes KW - feeding programs KW - fiber KW - food programs KW - nutrition programs KW - United States of America KW - vegetable crops KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404620&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians. AU - Baier, L. J. AU - Dobberfuhl, A. M. AU - Pratley, R. E. AU - Hanson, R. L. AU - Bogardus, C. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1998/// VL - 83 IS - 8 SP - 2993 EP - 2996 SN - 0021-972X AD - Baier, L. J.: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016. N1 - Accession Number: 19981415672. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition N2 - Electrophoretic variants of the vitamin D-binding protein (DBP) have been associated with type 2 diabetes as well as with metabolic characteristics that predispose to type 2 diabetes in several populations. The Gc gene that encodes DBP maps to chromosome 4q12, a region that has been found to be potentially linked to plasma glucose and insulin concentrations in Pima Indians. Therefore, the gene that encodes DBP was analyzed as a candidate gene for the authors' linkage findings in the Pima Indians. Sequence analysis of the coding exons identified 2 previously described missense polymorphisms at codons 416 and 420, which are the genetic basis for the 3 common electrophoretic variants of DBP (Gc1f, Gc1s and Gc2). These variants in DBP were associated with differences in oral glucose tolerance in nondiabetic Pima Indians. KW - binding proteins KW - ethnic groups KW - genetic variation KW - glucose tolerance KW - vitamin D KW - vitamins KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood sugar tolerance KW - carrier proteins KW - genetic variability KW - genotypic variability KW - genotypic variation KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415672&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - In situ lipolytic responses to isoproterenol and physiological stressors are similar in obese Pima Indians and Caucasians. AU - Snitker, S. AU - Hellmér, J., Jr. AU - Boschmann, M. AU - Odeleye, O. E. AU - Monroe, M. B. AU - Young, J. B. AU - Ravussin, E. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1998/// VL - 83 IS - 11 SP - 4054 EP - 4058 SN - 0021-972X AD - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19991400188. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 56-81-5, 299-95-6, 51-30-9, 6700-39-6, 76853-59-2. Subject Subsets: Human Nutrition N2 - The lipolytic response to adrenergic stimulation was tested in Pima Indians, a population prone to obesity and type 2 diabetes mellitus, to determine if it is lower than in Caucasians. 48 healthy, non-diabetic subjects were studied: 27 Pima Indians (12 males and 15 females, 30±7 years, 85±18 kg, 36±10% body fat) and 21 Caucasians (11 males and 10 females, 34±7 years, 105±26 kg, 39±11% body fat). Lipolysis in the abdominal subcutaneous adipose tissue was assessed in situ by glycerol concentration in microdialysis samples at baseline and during local infusion of the non-selective β-adrenergic agonist isoproterenol (10-6 mol/litre), mental stress and submaximal exercise. The baseline dialysate glycerol concentrations were similar in Pima Indians and Caucasians. Lipolytic response (relative increment in dialysate glycerol concentration, percentage above the baseline) was similar in Pima Indians and Caucasians in response to local isoproterenol infusion (77±36 and 76±40%) and exercise (38±38 and 41±41%). During mental stress, the dialysate concentration did not change significantly from baseline in either group. Changes in local blood flow, determined by ethanol dilution, did not differ between the 2 groups. In conclusion, the high propensity for obesity in Pima Indians does not seem to be due to an impaired lipolytic response to stimuli. KW - adrenergic innervation KW - beta-adrenergic agonists KW - ethnicity KW - exercise KW - glycerol KW - haemodynamics KW - isoprenaline KW - lipid metabolism KW - lipids KW - lipolysis KW - mental stress KW - obesity KW - Arizona KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mountain States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southwestern States of USA KW - ethnic differences KW - fat metabolism KW - fatness KW - glycerin KW - glycerine KW - hemodynamics KW - isoproterenol KW - lipins KW - psychological stress KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400188&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium inui is not closely related to other quartan Plasmodium species. AU - Kissinger, J. C. AU - Collins, W. E. AU - Li Jun AU - McCutchan, T. F. JO - Journal of Parasitology JF - Journal of Parasitology Y1 - 1998/// VL - 84 IS - 2 SP - 278 EP - 282 SN - 0022-3395 AD - Kissinger, J. C.: Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980807836. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology N2 - Plasmodium inui is a malarial parasite of Old World monkeys that occurs in isolated pockets throughout the Celebes, Indonesia, Malaysia and the Philippines and has traditionally been considered to be more closely related to P. malariae of humans (and its primate counterpart P. brasilianum), than to other primate Plasmodium species. This inference was made partly because of similarities in the periodicities or duration of the asexual cycle in the blood, the extended sporogonic cycle and the longer period of time for development of the pre-erythrocytic stages in the liver. Both P. inui and P. malariae have quartan (72 h) periodicities associated with their asexual cycle, whereas other primate malarias, such as P. fragile and P. cynomolgi, are associated with tertian periodicities (48 h) and P. knowlesi, with a quotidian (24 h) periodicity. Phylogenetic analyses of portions of orthologous small subunit ribosomal genes revealed that P. inui is actually more closely related to Plasmodium species of the "vivax-type" lineage than to P. malariae. Ribosomal sequence analysis of 18 different, geographically isolated, antigenically distinct P. inui isolates revealed that they are nearly identical in sequence and therefore represent the same species. KW - development KW - genes KW - life cycle KW - malaria KW - molecular taxonomy KW - nucleotide sequences KW - parasites KW - periodicity KW - phylogeny KW - ribosomal RNA KW - species KW - taxonomy KW - Indonesia KW - Malaysia KW - Philippines KW - monkeys KW - Plasmodium KW - Plasmodium brasilianum KW - Plasmodium cynomolgi KW - Plasmodium fragile KW - Plasmodium inui KW - Plasmodium knowlesi KW - Plasmodium malariae KW - Plasmodium vivax KW - Primates KW - protozoa KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Plasmodium KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - Commonwealth of Nations KW - Threshold Countries KW - DNA sequences KW - rRNA KW - systematics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807836&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: fluorescent staining of zygotes and ookinetes to study malaria parasites in mosquito. AU - Mohammed Shahabuddin AU - Gayle, M. AU - Zieler, H. AU - Laughinghouse, A. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 88 IS - 2 SP - 79 EP - 84 SN - 0014-4894 AD - Mohammed Shahabuddin: Medial Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980806469. Publication Type: Journal Article. Corporate Author: Shahabuddin, M. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - A fluorescent labelling method is described which can be used to stain the mosquito stages of Plasmodium. PKH26 was efficiently incorporated into the membranes of P. gallinaceum zygotes and ookinetes. Stained zygotes underwent normal development into ookinetes, and the stain did not affect ookinete mobility or ability to adhere to the luminal surface of the midgut of Aedes aegypti. KW - fluorescent dyes KW - ookinetes KW - parasites KW - staining KW - stains KW - techniques KW - zygotes KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806469&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: differential killing of some mosquito stages of the parasite by insect defensin. AU - Shahabuddin, M. AU - Fields, I. AU - Bulet, P. AU - Hoffmann, J. A. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 89 IS - 1 SP - 103 EP - 112 SN - 0014-4894 AD - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, Bethesda, MD 20892, USA. N1 - Accession Number: 19990500056. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - The action of defensins from an evolutionarily ancient insect (Aeshna cyanea) and a recent insect (Phormia terraenovae) were compared. Plasmodium gallinaceum zygotes were incubated in 250 µM solutions of the antibacterial peptides, Phormia defensin, Aeschna defensin, metalnikowin, thanatin, drosocin and metchnikowin. Development of zygotes to ookinetes showed that the peptides are not toxic to zygotes or developing ookinetes. When tested on mature ookinetes, none of the peptides affected the zygotes or ookinetes of P. gallinaceum. Aeschna defensin was found not to affect the transformation of mature ookinetes to oocysts. Under standard conditions it took ~8-9 days for the parasite to develop into a mature oocyst and 10-12 days to release sporozoites for invasion of the salivary glands. When Aedes aegypti were injected with defensin, oocysts appeared to be abnormal if treated 5, 6 or 7 days post blood-meal.The density of abnormal oocytes increased from 4 to 7 days post injection. The minimum amount of insect defensin required to produce abnormal oocysts was 2.5 µM. When treated with antibacterial peptides, only Aeschna and Phormia defensin-treated sporozoites were damaged. When compared Aeschna defensin was found to act more rapidly on gram-positive bacteria than Phormia defensin. It is thought that the defensins act by altering the membrane permeability of oocysts. KW - antibacterial agents KW - defensins KW - developmental stages KW - disease vectors KW - host parasite relationships KW - in vitro KW - mosquito-borne diseases KW - parasites KW - peptides KW - toxicity KW - Aedes aegypti KW - Aeshna cyanea KW - Culicidae KW - Diptera KW - Phormia terraenovae KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Aeshna KW - Aeshnidae KW - Odonata KW - Phormia KW - Calliphoridae KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - blackbottle KW - drosocin KW - growth phase KW - metalnikowin KW - metchnikowin KW - mosquitoes KW - parasite host relationships KW - thanatin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmania: amastigotes synthesize conserved secretory acid phosphatase during human infection. AU - Ellis, S. L. AU - Shakarian, A. M. AU - Dwyer, D. M. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 89 IS - 2 SP - 161 EP - 168 SN - 0014-4894 AD - Ellis, S. L.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 4, Room 126, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980808694. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9001-77-8. Subject Subsets: Protozoology N2 - Sera from patients with acute Leishmania infections (L. donovani, L. tropica, L. major, L. mexicana, L. braziliensis) were tested for anti-soluble acid phosphatase (SAcPs) antibodies using L. donovani promastigote culture supernatants. Sera from patients with visceral leishmaniasis from different endemic foci (Brazil, India, Kenya, Sudan) and also from patients with various forms of cutaneous leishmaniasis were shown to produce antibodies against SAcPs, indicating that Leishmania amastigotes produce SAcPs during infections in man. KW - acid phosphatase KW - amastigotes KW - antibodies KW - biochemistry KW - cutaneous leishmaniasis KW - human diseases KW - parasites KW - visceral leishmaniasis KW - Brazil KW - India KW - Kenya KW - Sudan KW - Leishmania KW - Leishmania braziliensis KW - Leishmania donovani KW - Leishmania major KW - Leishmania mexicana KW - Leishmania tropica KW - man KW - protozoa KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Leishmania KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Commonwealth of Nations KW - South Asia KW - Asia KW - ACP Countries KW - Anglophone Africa KW - Africa KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - acid phosphomonoesterase KW - secretory proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808694&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase. AU - Ribeiro, J. M. C. AU - Mather, T. N. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 89 IS - 2 SP - 213 EP - 221 SN - 0014-4894 AD - Ribeiro, J. M. C.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bulding 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19990500181. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 1407-47-2, 58-82-2, 7440-48-4, 7439-96-5. Subject Subsets: Medical & Veterinary Entomology N2 - The authors show that tick kininase activity behaves as a metalloenzyme that removes two amino acids at a time from bradykinin up to fragment 1-5, with fragment 1-7 appearing transiently. Tick kininase was purified from I. scapularis by HPLC. Incubation of kininase with bradykinin produced time-dependent disappearance of the bradykinin peak. The activity of the kininase was shown to be significantly enhanced by the manganese and cobalt. The tick salivary kininase was shown to have properties in common with angiotensin-converting enzyme although after a 3 h incubation with angiotensin I, <10% was hydrolysed demonstrating a specificity for bradykinin. Insufficient pure enzyme was obtained for amino acid sequencing. KW - angiotensin KW - bradykinin KW - cobalt KW - dipeptidyl carboxypeptidases KW - enzyme activity KW - enzymes KW - hydrolases KW - manganese KW - metalloproteinases KW - saliva KW - Acari KW - Arachnida KW - Ixodes scapularis KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Ixodes KW - Ixodidae KW - Metastigmata KW - Acari KW - kininases KW - Mn KW - salivary secretions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500181&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparum: parasite typing by using a multicopy microsatellite marker, PfRRM. AU - Su XinZhuan AU - Carucci, D. J. AU - Wellems, T. E. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 89 IS - 2 SP - 262 EP - 265 SN - 0014-4894 AD - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20982-0425, USA. N1 - Accession Number: 19980808705. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology N2 - Microsatellite PfRRM fingerprinting of 16 field isolates of Plasmodium falciparum is described. Multiple bands were seen for all parasite DNAs, and each parasite had a unique band pattern. PfRRM was also used to type and verify the identity of four 3D7 clones maintained in different laboratories. Labelling the PCR product with [F]dUTP avoided the use of radioactive materials, and allowed the use of an automatic DNA sequencer. KW - clones KW - DNA fingerprinting KW - identification KW - molecular genetics KW - parasites KW - polymerase chain reaction KW - strains KW - techniques KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808705&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Leishmania tropica: the identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease. AU - Lira, R. AU - Méndez, S. AU - Carrera, L. AU - Jaffe, C. AU - Neva, F. AU - Sacks, D. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 89 IS - 3 SP - 331 EP - 342 SN - 0014-4894 AD - Lira, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980808764. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology N2 - The use of anti-lipophosphoglycan monoclonal antibodies for the purification of Leishmania tropica metacyclic promastigotes from axenic culture is described. A non-healing, non-progressive form of cutaneous leishmaniasis was reproducibly established in BALB/c mice using these metacyclic promastigotes. Differences in disease progression were found in mice and hamster models using metacyclic promastigotes purified from cutaneous, visceral and viscerotropic (Desert Storm) isolates. A role for parasite-related determinants in the clinical spectrum of disease is suggested. KW - clinical aspects KW - cutaneous leishmaniasis KW - disease models KW - experimental infections KW - host parasite relationships KW - identification KW - laboratory animals KW - lipophosphoglycans KW - monoclonal antibodies KW - parasites KW - promastigotes KW - purification KW - techniques KW - visceral leishmaniasis KW - hamsters KW - Leishmania tropica KW - mice KW - protozoa KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - clinical picture KW - metacyclic promastigotes KW - parasite host relationships KW - viscerotropic leishmaniasis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808764&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term feeding of sodium saccharin to nonhuman primates: Implications for urinary tract cancer. AU - Takayama, S. AU - Sieber, S. M. AU - Adamson, R. H. AU - Thorgeirsson, U. P. AU - Dalgard, D. W. AU - Arnold, L. L. AU - Cano, M. AU - Eklund, S. AU - Cohen, S. M. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 1 SP - 19 EP - 25 SN - 0027-8874 AD - Takayama, S.: Division of Basic Sciences, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981408514. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 81-07-2. Subject Subsets: Human Nutrition N2 - Twenty monkeys of 3 species (6 African green, 7 rhesus, 6 cynomolgus, and one hybrid (of rhesus male and cynomolgus female parentage)) were given sodium saccharin in the diet 25 mg/kg body weight daily for 5 days per week, beginning within 24 h after birth and continuing for up to 24 years. Sixteen monkeys (7 rhesus and 9 cynomolgus) served as controls. During their last 2 years of life, urine was collected from selected treated and control animals and evaluated for various urinary chemistries and for the presence of calculi, microcrystalluria and precipitate. Urinary bladders were examined by light microscopy and by scanning electron microscopy. Sodium saccharin treatment had no effect on the urine or urothelium in any of these monkeys. There was no evidence of increased urothelial cell proliferation, and there was no evidence of formation of solid material in the urine. Although the dose of sodium saccharin administered to these monkeys was only 5-10 times the allowable daily intake for man, the results provide additional evidence that sodium saccharin is without a carcinogenic effect on the primate urinary tract. KW - artificial sweeteners KW - bladder KW - carcinogenesis KW - neoplasms KW - renal calculi KW - saccharin KW - species differences KW - sweeteners KW - urinary tract KW - urine KW - monkeys KW - Primates KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - kidney calculi KW - kidney stones KW - urinary bladder KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408514&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. AU - Chow WongHo AU - Blot, W. J. AU - Vaughan, T. L. AU - Risch, H. A. AU - Gammon, M. D. AU - Stanford, J. L. AU - Dubrow, R. AU - Schoenberg, J. B. AU - Mayne, S. T. AU - Farrow, D. C. AU - Habibul Ahsan AU - West, A. B. AU - Rotterdam, H. AU - Niwa, S. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 2 SP - 150 EP - 155 SN - 0027-8874 AD - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981408512. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - Anthropometric risk factors were examined in a population-based case-control study of oesophageal and gastric cancers in Connecticut, New Jersey, and western Washington, USA. Healthy control subjects (n=695) and case patients with oesophageal squamous cell carcinoma or noncardia gastric adenocarcinoma (n=589) were frequency-matched to case patients with adenocarcinomas of oesophagus or gastric cardia (n=554) by 5-year age groups, sex, and race (New Jersey only). Classification of cases by tumour site of origin and histology was determined by review of pathology materials and hospital records. Data were collected using in-person structured interviews. Associations with obesity, measured by body mass index (BMI), were estimated by odds ratios (ORs). All ORs were adjusted for geographic location, age, sex, race, cigarette smoking, and proxy response status. The ORs for oesophageal adenocarcinoma increased with increasing adult BMI. The magnitude of association with BMI was greater among the younger age groups and among nonsmokers. The ORs for gastric cardia adenocarcinoma rose moderately with increasing BMI. Adult BMI was not associated with risk of oesophageal squamous cell carcinoma or noncardia gastric adenocarcinoma. Increasing prevalence of obesity in the US population may have contributed to the upward trends in oesophageal and gastric cardia adenocarcinomas. KW - adenocarcinoma KW - age KW - anthropometric dimensions KW - body weight KW - carcinoma KW - neoplasms KW - obesity KW - oesophageal diseases KW - oesophagus KW - risk factors KW - stomach KW - tobacco smoking KW - Connecticut KW - New Jersey KW - USA KW - Washington KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Middle Atlantic States of USA KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - anthropometric measurements KW - cancers KW - esophageal diseases KW - esophagus KW - fatness KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408512&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum: use of antisera to degenerate synthetic peptides derived from the active site of protozoal chitinases to characterize an ookinete-specific chitinase. AU - Vinetz, J. M. AU - Kaslow, D. C. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1998/// VL - 90 IS - 2 SP - 199 EP - 202 SN - 0014-4894 AD - Vinetz, J. M.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990802281. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 9001-06-3. Subject Subsets: Protozoology KW - biochemistry KW - chitinase KW - enzymes KW - ookinetes KW - parasites KW - synthetic peptides KW - Plasmodium gallinaceum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - ookinete-specific chitinase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802281&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Diet during adolescence and risk of breast cancer among young women. AU - Potischman, N. AU - Weiss, H. A. AU - Swanson, C. A. AU - Coates, R. J. AU - Gammon, M. D. AU - Malone, K. E. AU - Brogan, D. AU - Stanford, J. L. AU - Hoover, R. N. AU - Brinton, L. A. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 3 SP - 226 EP - 233 SN - 0027-8874 AD - Potischman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981404146. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - Risk of early-onset breast cancer was examined in relation to diet during adolescence in a case-control study in the USA. Study participants were accrued from the following 3 geographical regions covered by cancer registries: Atlanta, GA; Seattle/Puget Sound, WA; and central New Jersey. Case patients (n=1647) were newly diagnosed with breast cancer in 1990-92, and control subjects (n=1501) were identified by random-digit-dialling techniques in the same period. In an interview, each subject was asked to recall the frequency of consumption and portion size of 29 key food items at ages 12-13 years. Mothers of a subset of respondents completed questionnaires and food groups were recalculated after removal of foods with poor agreement between mother and daughter. Logistic regression analyses were used to calculate odds ratios and 95% confidence intervals. When high vs. low quartiles of consumption were compared, there was a suggestion of a reduced risk associated with high consumption of fruits and vegetables, although this finding was not significant. Slight increases (of borderline significance) in risk of breast cancer were found for intake of chicken or high-fat meat. Intake of animal fat, high-fat foods, high-fat snacks and desserts, or milk products during adolescence had no apparent influence on breast cancer risk. Removal of foods suspected to be poorly recalled by the daughters did not change any of the risk estimates. It was concluded that these data do not provide evidence for a strong influence of dietary intakes during adolescence on risk of early-onset breast cancer. KW - adolescents KW - animal fat KW - breast KW - breast cancer KW - children KW - desserts KW - diet studies KW - fat KW - fruit KW - mammary gland neoplasms KW - mammary glands KW - meat KW - milk products KW - neoplasms KW - risk KW - vegetables KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - breasts KW - cancers KW - dairy products KW - mammary tumour KW - teenagers KW - United States of America KW - vegetable crops KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404146&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a black population. AU - Manns, A. AU - Hanchard, B. AU - Morgan, O. St. C. AU - Wilks, R. AU - Cranston, B. AU - Nam JunMo AU - Blank, M. AU - Kuwayama, M. AU - Yashiki, S. AU - Fujiyoshi, T. AU - Blattner, W. AU - Sonoda, S. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 8 SP - 617 EP - 622 SN - 0027-8874 AD - Manns, A.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19982007783. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - HLA class II alleles were studied among asymptomatic HTLV-I carriers (n = 45), patients with adult T-cell leukaemia/lymphoma (ATL; n = 49) or HTLV-I-associated myelopathy (HAM/TSP; n = 54), and HTLV-I-seronegative control subjects (n = 51) in Kingston, Jamaica. All participants were of African descent. Two antigens determined by serotyping, DR15 and DQ1, occurred at significantly increased frequency among HTLV-I carriers compared with seronegative control subjects (42% versus 22% for DR15 [odds ratio {OR} = 2.7; 95% confidence interval {CI} = 1.0-7.2] and 78% versus 53% for DQ1 [OR = 3.1; 95% CI = 1.2-8.5]). Asymptomatic carriers were shown to have an HLA class II allele distribution similar to that of patients with ATL, and the frequencies of the alleles DRB1*1501, DRB1*1101, and DQB1*0602 were significantly greater in patients with ATL and asymptomatic carriers than in patients with HAM/TSP. In addition, haplotypes DRB1*1101-DQB1*0301 and DRB1*1501-DQB1*0602 were significantly increased among patients with ATL compared with patients with HAM/TSP. These data suggest that host genetic background is an important factor in determining whether HTLV-I carriers develop either ATL or HAM/TSP. KW - adult T-cell leukaemia KW - alleles KW - antigens KW - asymptomatic infections KW - carriers KW - chronic course KW - classification KW - disease course KW - hosts KW - human diseases KW - identification KW - infection KW - major histocompatibility complex KW - myelopathy KW - serotypes KW - spastic paraparesis KW - T lymphocytes KW - tropical spastic paraparesis KW - Caribbean KW - Jamaica KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - human T-cell lymphotropic virus type I KW - man KW - Deltaretrovirus KW - viruses KW - Human T-cell lymphotropic virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - adult T-cell leukemia KW - antigenicity KW - disease progression KW - histocompatibility complex KW - HTLV-BLV group KW - immunogens KW - T cells KW - West Indies KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007783&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica. AU - Manns, A. AU - Strickler, H. D. AU - Hanchard, B. AU - Manassaram, D. M. AU - Waters, D. AU - Ablashi, D. V. T2 - Journal of the National Cancer Institute JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 14 SP - 1102 EP - 1104 SN - 0027-8874 AD - Manns, A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19982011326. Publication Type: Correspondence. Language: English. Number of References: 6 ref. Subject Subsets: Tropical Diseases N2 - The seroprevalence of human herpesvirus 8 (HHV-8) was analysed by ELISA and immunofluorescence assay among 2 Jamaican populations: 250 normal blood donors (median age 41 years, range 18-64 years; 50% female) in Kingston and 146 women (median age 33 years, range 19-78 years) attending gynaecology clinics in Kingston. The overall seroprevalence among the blood donors tested was 3.6% (9/250), with 5.0% (6/119) of the men and 2.4% (3/122) of the women having detectable levels of HHV-8 antibodies. Men were 2 times more likely to be seropositive than women (odds ratio=2.1; 95% confidence interval [CI]=0.43-12.9). Blood donors aged >40 years had a 2.9-fold greater likelihood of HHV-8 seropositivity (odds ratio=2.89; 95% CI=0.53-29), and the highest number of seropositives (6.9%) among both sexes was detected in individuals over the age of 50 years. Among the women attending the gynaecology clinics, only one patient (aged 44 years) of 146 (0.68%) was seropositive. These results indicate that the seroprevalence of HHV-8 among the Jamaican population varies predominantly by age and sex. KW - adults KW - age KW - blood donors KW - epidemiology KW - human diseases KW - seroprevalence KW - sex KW - viral diseases KW - Jamaica KW - Herpesviridae KW - Human herpesvirus 4 KW - human herpesvirus 8 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - Rhadinovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Epstein-Barr virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011326&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. AU - Silverman, D. T. AU - Swanson, C. A. AU - Gridley, G. AU - Wacholder, S. AU - Greenberg, R. S. AU - Brown, L. M. AU - Hayes, R. B. AU - Swanson, G. M. AU - Schoenberg, J. B. AU - Pottern, L. M. AU - Schwartz, A. G. AU - Fraumeni, J. F., Jr. AU - Hoover, R. N. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1998/// VL - 90 IS - 22 SP - 1710 EP - 1719 SN - 0027-8874 AD - Silverman, D. T.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19981418723. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Human Nutrition N2 - Dietary factors were evaluated to determine whether the higher incidence of pancreatic cancer experienced by black Americans compared with white Americans could be explained. A population-based case-control study of pancreatic cancer diagnosed in Atlanta, Detroit and 10 New Jersey counties, USA, from August 1986 to April 1989 was carried out. Reliable dietary histories were obtained for 436 subjects and 2003 general-population control subjects aged 30-79 years. Obesity was associated with a significant 50%-60% increased risk of pancreatic cancer that was consistent by sex and race. Although the magnitude of risk associated with obesity was identical in blacks and whites, a higher percentage of blacks were obese than were whites (women 38 vs. 16%; men 27 vs. 22%). A significant positive trend in risk was observed with increasing energy intake, with subjects in the highest quartile of energy intake experiencing a 70% higher risk than those in the lowest quartile. A significant interaction between body mass index (weight in kg/height in m² for men and weight in kg/height in m1.5 for women) and total energy intake was observed that was consistent by sex and race. Subjects in the highest quartile of body mass index and energy intake had a significant 180% higher risk than those in the lowest quartile. It is concluded that obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk of pancreatic cancer among blacks than among whites in the USA, particularly among women. The interaction between body mass index and energy intake suggests the importance of energy balance in pancreatic carcinogenesis. KW - anthropometric dimensions KW - blacks KW - carcinogenesis KW - diet KW - dietary history KW - energy balance KW - energy intake KW - ethnic groups KW - ethnicity KW - neoplasms KW - nutrition KW - obesity KW - pancreas KW - risk factors KW - Georgia KW - Michigan KW - New Jersey KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southeastern States of USA KW - East North Central States of USA KW - North Central States of USA KW - Lake States of USA KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - anthropometric measurements KW - cancers KW - ethnic differences KW - fatness KW - food history KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418723&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcγ receptors and expression of monokines. AU - Swapan, K. De AU - Venkateshan, C. N. S. AU - Seth, P. AU - Gajdusek, D. C. AU - Gibbs, C. J. Jr. JO - Blood JF - Blood Y1 - 1998/// VL - 91 IS - 6 SP - 2108 EP - 2117 SN - 0006-4971 AD - Swapan, K. De: Oral Infection and Immunity Branch, National Institute of Dental Research, the Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982005288. Publication Type: Journal Article. Language: English. Number of References: 105 ref. Registry Number: 308079-78-9. N2 - To characterize the effect of HIV-1 nef expression in human monocytes/macrophage (HMØ) and U937 on the levels of FcγRs, HLA antigens, and monokines, elutriated HMØs and U937 cells were transfected with an adenovirus-mediated Nef expression system. Nef-expressing cells downmodulated FcγRI, FcγRII, and upregulated HLA class I molecules. Nef-expressing HMØs, treated with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA), overexpressed tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-10. However, IL-6 was induced by LPS and inhibited by PMA. Additionally, a subpopulation of Nef-expressing HMØs underwent apoptosis. These data suggest that HIV-1 nef downmodulated FcγRs in myeloid cells in a manner similar to that previously reported for its effect on CD4 in T cells. KW - antigens KW - apoptosis KW - macrophages KW - monocytes KW - Nef protein KW - pathogenesis KW - receptors KW - tumour necrosis factor KW - Adenoviridae KW - Human immunodeficiency virus 1 KW - dsDNA viruses KW - DNA viruses KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - antigenicity KW - cachectin KW - cachexin KW - human immunodeficiency virus type 1 KW - immunogens KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Episomal and integrated maintenance of foreign DNA in Giardia lamblia. AU - Singer, S. M. AU - Yee, J. AU - Nash, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1998/// VL - 92 IS - 1 SP - 59 EP - 69 SN - 0166-6851 AD - Singer, S. M.: Laboratory of Parasitic Disease, Building 4/Room B1-06, 9000 Rockville Pike, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980806279. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9007-49-2, 53-79-2. Subject Subsets: Protozoology; Agricultural Biotechnology N2 - A method was developed for stably introducing DNA into the nuclei of Giardia lamblia [G. duodenalis] using puromycin acetyltransferase (pac) as a dominant selectable marker. Transfected circular DNAs were maintained as episomes in the isolate WB, a representative of one Giardia subgroup. When input DNAs were linearized, integration occurred by homologous recombination, producing gene replacements in this isolate. In isolate GS, which represents a different subgroup, both linear and circular transfected DNAs were integrated into the genome by homologous recombination. In GS, linear DNA again produced gene replacements, whereas circular DNA produced duplicative integration events. The failure of GS to replicate episomes may reflect differences in the structure or recognition of DNA replication origins between these subgroups. A plasmid shuttle vector was also developed for expression of other genes in G. lamblia. Utilizing the green fluorescent protein as a reporter gene in the WB isolate, it was shown that gene expression from this vector correlated with plasmid copy number over a range of 2 orders of magnitude. KW - biotechnology KW - DNA KW - molecular genetics KW - parasites KW - plasmids KW - puromycin KW - recombination KW - reporter genes KW - transfection KW - Giardia duodenalis KW - protozoa KW - Giardia KW - Hexamitidae KW - Diplomonadida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - deoxyribonucleic acid KW - gene replacements KW - genetic recombination KW - puromycin acetyltransferase KW - reporter gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806279&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected. AU - Tisdale, J. F. AU - Stewart, A. K. AU - Dickstein, B. AU - Little, R. F. AU - Dubé, I. AU - Cappe, D. AU - Dunbar, C. E. AU - Brown, K. E. JO - Blood JF - Blood Y1 - 1998/// VL - 92 IS - 8 SP - 2681 EP - 2687 SN - 0006-4971 AD - Tisdale, J. F.: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA. N1 - Accession Number: 19992001524. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health N2 - Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig (et al.) Science (1997) 276, 1851-1854). In this study, the authors sought to confirm these observations in their own group of MM patients (n=30). DNA was extracted from adherent stromal cells grown under varying conditions and assayed for HHV-8 sequence using PCR to amplify the orf 26 (KS330) sequence (Chang et al.Science (1994) 266, 1865-1869), as initially reported. Samples from human control subjects (n=25) were concurrently extracted and analysed. After 30 cycles of amplification, no positive samples were detected. In a more sensitive nested PCR, samples from 18 of 30 (60%) MM patients were positive, at about the limit of detection, but orf 26 sequence was also amplified from 11 of 25 (44%) human control samples. However, PCR amplification from other regions of the viral genome (orf 72 and orf 75) was uniformly negative for all MM and control samples, despite equivalent sensitivity. Additionally, all sera from MM patients were negative for HHV-8 IgG by immunofluorescence. It is concluded that the data do not support a role of HHV-8 in the aetiology of MM but may suggest the presence of a related (KS330-containing) virus in MM patients and in some control subjects. KW - aetiology KW - DNA amplification KW - human diseases KW - IgG KW - myeloma KW - neoplasms KW - plasma cells KW - polymerase chain reaction KW - serology KW - seroprevalence KW - human herpesvirus 8 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Rhadinovirus KW - Gammaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - causal agents KW - etiology KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001524&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. AU - Jin DongYan AU - Spencer, F. AU - Jeang KuanTeh JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1998/// VL - 93 IS - 1 SP - 81 EP - 91 SN - 0092-8674 AD - Jin DongYan: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19982006875. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - A search for cellular targets of the HTLV-I oncoprotein Tax identified TXBP181, which was characterized as the human homologue of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatment of cells with nocodazole, and binding to HsMAD2. HsMAD1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss of HsMAD1 function. A model of viral transformation is proposed in which Tax targets TXBP181, thereby abrogating a midpoint checkpoint. KW - human diseases KW - mitosis KW - pathogenesis KW - phenotypes KW - proteins KW - T lymphocytes KW - Tax protein KW - treatment KW - yeasts KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - fungi KW - eukaryotes KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - fungus KW - HTLV-BLV group KW - oncogenesis KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006875&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular epidemiology of human polyomavirus JC in the Biaka Pygmies and Bantu of Central Africa. AU - Chima, S. C. AU - Ryschkewitsch, C. F. AU - Stoner, G. L. JO - Memórias do Instituto Oswaldo Cruz JF - Memórias do Instituto Oswaldo Cruz Y1 - 1998/// VL - 93 IS - 5 SP - 615 EP - 623 SN - 0074-0276 AD - Chima, S. C.: Neurotoxicology Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992004129. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Tropical Diseases N2 - Based on sequence analysis of JCV complete genomes or fragments thereof, polyomavirus JC (JCV) can be classified into geographically derived genotypes. Types 1 and 2 are of European and Asian origin, respectively, whereas Types 3 and 6 are African in origin. Type 4, a possible recombinant of European and African genotypes (1 and 3) is common in the USA. To delineate the JCV genotypes in an aboriginal African population, random urine samples were collected from the Biaka Pygmies and Bantu from the Central African Republic. The study group consisted of 43 males and 25 females aged 4-55 years, with an average age of 26 years. After PCR amplification of JCV in urine, products were sequenced. Five of 23 Pygmy adults (22%) and 4 of 20 Bantu adults (20%) were positive for JC viruria. DNA sequence analysis revealed JCV Type 3, Type 6 and Type 1 variants in 2, 2 and 1 Biaka Pygmies, respectively. All the Bantu strains were Type 6. It is suggested that the presence of multiple subtypes of JCV in Biaka Pygmies may be a result of extensive interactions of Pygmies with their African tribal neighbours. KW - disease prevalence KW - genetic variation KW - genotypes KW - human diseases KW - molecular epidemiology KW - Central African Republic KW - JC polyomavirus KW - man KW - Polyomavirus KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - genetic variability KW - genotypic variability KW - genotypic variation KW - JC virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004129&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission of spongiform encephalopathy through biological products. AU - Brown, P. JO - Developments in Biological Standardization JF - Developments in Biological Standardization Y1 - 1998/// VL - 93 SP - 73 EP - 78 SN - 0301-5149 AD - Brown, P.: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992202447. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Veterinary Science KW - blood KW - blood plasma KW - bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - disease transmission KW - grafts KW - prion diseases KW - public health KW - spongiform encephalopathy KW - bovine encephalopathy KW - BSE KW - mad cow disease KW - plasma (blood) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202447&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An amino terminal intron indicates that transcripts for the Plasmodium falciparum Golgi network marker Rab6 do not encode alternative amino termini. AU - Templeton, T. J. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1998/// VL - 94 IS - 1 SP - 149 EP - 153 SN - 0166-6851 AD - Templeton, T. J.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room B1-31, NIAID/NIH, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980808811. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology N2 - The 5′ end of the pfrab6 gene of Plasmodium falciparum was analysed in detail for the presence of introns. From the results it is concluded that a single rab6 gene exists in the P. falciparum genome, and the identification of an amino terminal intron indicates that pfrab6 does not posess alternative amino termini. Nucleotide sequence data have been submitted to GenBank under accession number AF035011. KW - amino acid sequences KW - complementary DNA KW - endoplasmic reticulum KW - genes KW - Golgi apparatus KW - introns KW - molecular genetics KW - nucleotide sequences KW - parasites KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cDNA KW - DNA sequences KW - pfrab6 KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808811&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers. AU - Wellems, T. E. AU - Wootton, J. C. AU - Fujioka, H. AU - Su XinZhuan AU - Cooper, R. AU - Baruch, D. AU - Fidock, D. A. JO - Cell (Cambridge) JF - Cell (Cambridge) Y1 - 1998/// VL - 94 IS - 3 SP - 285 EP - 286 SN - 0092-8674 AD - Wellems, T. E.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980808296. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 1333-74-0, 7440-23-5. Subject Subsets: Protozoology N2 - Evidence is presented to show that the CG2 protein gene (cg2) of Plasmodium falciparum, which has been linked to chloroquine resistance, does not encode a sodium/hydrogen exchanger (NHE) responsible for drug transport, as has been proposed. A detailed reanalysis of the CG2 sequence failed to support claims for significant similarity to functional features of well-characterized eukaryotic NHE transport domains. The possible role of CG2 in chloroquine resistance is discussed. KW - antimalarials KW - antiprotozoal agents KW - chloroquine KW - drug resistance KW - genes KW - human diseases KW - hydrogen KW - malaria KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - sodium KW - man KW - Plasmodium falciparum KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - biochemical genetics KW - CG2 protein KW - DNA sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808296&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A previously unidentified host protein protects retroviral DNA from autointegration. AU - Lee, M. S. AU - Cragie, R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 4 SP - 1528 EP - 1533 SN - 0027-8424 AD - Lee, M. S.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004440. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9007-49-2. KW - chromosomes KW - DNA KW - fibroblasts KW - genomes KW - hosts KW - human immunodeficiency viruses KW - integration KW - peptides KW - proteins KW - Escherichia coli KW - Retroviridae KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - bacterium KW - deoxyribonucleic acid KW - E. coli KW - human immunodeficiency virus KW - virions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004440&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge. AU - Belyakov, I. M. AU - Derby, M. A. AU - Ahlers, J. D. AU - Kelsall, B. L. AU - Earl, P. AU - Moss, B. AU - Strober, W. AU - Berzofsky, J. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 4 SP - 1709 EP - 1714 SN - 0027-8424 AD - Belyakov, I. M.: Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982004442. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9008-11-1. N2 - Intrarectal immunization with a synthetic, multideterminant HIV peptide plus cholera toxin adjuvant induced long-lasting, antigen specific cytotoxic T-lymphocyte (CTL) memory in both the inductive (Peyer's patch) and effector (lamina propria) mucosal sites, as well as in systemic sites (spleen), whereas systemic immunization induced specific CTLs only in the spleen. Cholera toxin adjuvant, while enhancing the response, was not essential. The CTLs recognized target cells either pulsed with HIV peptide or expressing endogenous whole envelope glycoprotein of Mr 160 000 (gp160). It is shown that mucosal CTL responses are both interleukin 12 and interferon-γ dependent by using antibody-treated and knock-out mice. Finally, it is shown that intrarectal immunization with the synthetic HIV peptide vaccine protected mice against infection via mucosal challenge with a recombinant vaccinia virus expressing HIV-1IIIB gp160. These studies provide an approach to development of an HIV vaccine that induces CTL immunity in the mucosal and systemic immune systems and protects against mucosal infection with a virus expressing HIV-1 gp160. KW - adjuvants KW - antigens KW - bacterial toxins KW - cholera KW - cytotoxic T lymphocytes KW - cytotoxicity KW - envelope glycoproteins KW - envelope protein gp160 KW - glycoproteins KW - human immunodeficiency viruses KW - immune response KW - immunity KW - immunization KW - infection KW - interferon KW - interleukins KW - lymphocytes KW - mucosa KW - peptides KW - spleen KW - T lymphocytes KW - toxins KW - vaccines KW - Human immunodeficiency virus 1 KW - mice KW - vaccinia virus KW - Vibrio cholerae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - gp160 KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - mucous membrane KW - recombinant viruses KW - T cells KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004442&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells. AU - Mahana, W. AU - Zhao, T. M. AU - Teller, R. AU - Robinson, M. A. AU - Kindt, T. J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 4 SP - 1782 EP - 1787 SN - 0027-8424 AD - Mahana, W.: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, NIH, 12441 Parklawn Drive, Rockville, MD 20892, USA. N1 - Accession Number: 19982004445. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - HTLV-I causes acute leukaemic disease in a low percentage of infected individuals through obscure mechanisms. These studies compare 2 rabbit HTLV-I-infected T-cell lines: one, RH/K34, causes lethal experimental leukaemia and the other, RN/K30, mediates asymptomatic infection. It is shown that the product of the protooncogene vav is constitutively Tyr-phosphorylated in RH/K34 but not in RH/K30. A role for the retrovirus in phosphorylation of Vav was assigned by transfection experiments with molecular clones of HTLV-I derived from the 2 lines. The HTLV-I molecular clone from RN/K30, but not that from RN/K34, down-regulates Vav phosphorylation in a Herpesvirus ateles-transformed T-cell line. Use of recombinant virus clones revealed that pX region sequence differing by 2 nucleotides between the 2 clones mediates this down-regulation. Because Vav is involved in T-cell signalling and Vav phosphorylation occurs upon activation of T cells, control of the activation state of Vav by viral proteins may relate to the leukaemogenic potential of certain HTLV-I-infected cells. KW - asymptomatic infections KW - cell lines KW - clones KW - genes KW - HTLV infections KW - human diseases KW - leukaemia KW - oncogenes KW - pathogenesis KW - proteins KW - T lymphocytes KW - viral proteins KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - rabbits KW - viruses KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - blood cancer KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - leucaemia KW - leukemia KW - T cells KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004445&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T cell lymphotropic virus type I Tax protein trans-activated interleukin 15 gene transcription through an NF-κB site. AU - Azimi, N. AU - Brown, K. AU - Bamford, R. N. AU - Tagaya, Y. AU - Siebenlist, U. AU - Waldmann, T. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 5 SP - 2452 EP - 2457 SN - 0027-8424 AD - Azimi, N.: Bldg 10, Rm 4N-102, National Cancer Institute, NIH 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19982005322. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - This study demonstrates that IL-15 mRNA can be detected in freshly isolated normal T cells and T cell lines. Furthermore, its expression is 3- to 4-fold higher in HTLV-I-infected T cells. By the use of reporter constructs bearing the 5′ regulatory region of the IL-15 gene, a positive correlation was observed between HTLV-I Tax protein expression and IL-15 promoter activity in HTLV-I-infected T cells. By using a Jurkat T cell transfectant that expresses Tax under an inducible promoter, it was also demonstrated that the expression of IL-15 mRNA increased 3-fold as Tax was expressed, suggesting that the Tax protein activates IL-15 transcription. An NF-κB consensus sequence is located at the -75 and -65 region of the IL-15 5′ regulatory region. Mutations in the NF-κB motif or deletion of this sequence abrogated the promoter activity in both HTLV-I-positive and Jurkat Tax-transfectant cells. KW - human diseases KW - interleukins KW - messenger RNA KW - mutations KW - pathogenesis KW - promoters KW - T lymphocytes KW - Tax protein KW - transactivation KW - transcription KW - transcription factors KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - DNA transcription KW - HTLV-BLV group KW - mRNA KW - nuclear factor kappaB KW - nuclear factors KW - promoter region KW - promoter sequences KW - T cells KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005322&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. AU - Conant, K. AU - Garzini-Demo, A. AU - Nath, A. AU - McArthur, J. C. AU - Halliday, W. AU - Power, C. AU - Gallo, R. C. AU - Major, E. O. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 6 SP - 3117 EP - 3121 SN - 0027-8424 AD - Conant, K.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bldg 36, Rm 5W21, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982005325. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. This study shows that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte chemoattractant protein-1 (MCP-1). Astrocytic release of β-chemokines, which are relatively less selective for monocytes, including RANTES, macrophage inflammatory protein-1α, and macrophage inflammatory protein-1β, was not observed. It is also shown that MCP-1 is expressed in the brains of patients with HIV-1-associated dementia and that, of the β-chemokines tested, only MCP-1 could be detected in the cerebrospinal fluid of patients with this condition. Together, these data provide a potential link between the presence of HIV-1 in the brain and the monocytic infiltration that may substantially contribute to dementia. KW - acquired immune deficiency syndrome KW - central nervous system KW - cerebrospinal fluid KW - chemokines KW - cytokines KW - dementia KW - eicosanoids KW - human diseases KW - macrophages KW - monocytes KW - nervous system diseases KW - pathogenesis KW - Tat protein KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CNS KW - human immunodeficiency virus type 1 KW - neuropathy KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum preferentially invades vesicular ATPase-expressing cells in Aedes aegypti midgut. AU - Mohammed Shahabuddin AU - Pimenta, P. F. P. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 7 SP - 3385 EP - 3389 SN - 0027-8424 AD - Mohammed Shahabuddin: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980807522. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9000-83-3. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - It was shown that the ookinetes of P. gallinaceum selectively invade a cell type in the A. aegypti midgut. These cells, unlike the majority of the cells in the midgut, do not stain with a basophilic dye (toluidine blue) and are less osmiophilic. In addition, they contain minimal endoplasmic reticulum, lack secretory granules, and have few microvilli. They are highly vacuolated and express large amounts of vesicular ATPase which is associated with the apical plasma membrane, cytoplasmic vesicles, and tubular extensions of the basal membrane of the invaded cells. KW - adenosinetriphosphatase KW - cell invasion KW - disease transmission KW - disease vectors KW - host parasite relationships KW - midgut KW - ookinetes KW - parasites KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - ATPase KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807522&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase. AU - Szczepanowska, J. AU - Ramachandran, U. AU - Herring, C. J. AU - Gruschus, J. M. AU - Jun Qin AU - Korn, E. D. AU - Brzeska, H. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 8 SP - 4146 EP - 4151 SN - 0027-8424 AD - Szczepanowska, J.: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980807404. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 72-19-5. Subject Subsets: Protozoology N2 - Phosphorylation of Ser-627 is both necessary and sufficient for full activity of the expressed 35-kDa catalytic domain of myosin I heavy chain kinase (MIHCK). The effects of individually substituting Ala, Asp and Glu for each of the 3 hydroxyamino acids (Ser-627, Thr-631 and Thr-632) in the variable loop of Acanthamoeba MIHCK was investigated. The S627A mutant was substantially less active than wild type (wt), with a lower kcat and higher Km for both peptide substrate and ATP, but was more active than unphosphorylated wt. The S627D and S627E mutants were also less active than phosphorylated wt, indicating that acidic amino acids could not substitute for phospho-Ser-627. The activity of the T631A mutant was as low as that of the S627A mutant, whereas the T632A mutant was as active as phosphorylated wt, indicating that highly conserved Thr-631, although not phosphorylated, was essential for catalytic activity. Asp and Glu substitutions for Thr-631 and Thr-632 were inhibitory to various extents. Molecular modelling indicated that Thr-631 could hydrogen bond with conserved residue Asp-591 in the catalytic loop and that similar interactions were possible for other kinases whose activities were also regulated by phosphorylation in the variable loop. It is therefore suggested that this conserved Thr residue may be essential for the activities of other Ser/Thr protein kinases as well as for the activity of MIHCK. KW - activity KW - amino acids KW - biochemistry KW - kinases KW - myosins KW - parasites KW - phosphorylation KW - threonine KW - Acanthamoeba KW - protozoa KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - myosin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980807404&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. AU - Lubkowski, J. AU - Yang, F. AU - Alexandratos, J. AU - Wlodawer, A. AU - Zhao He AU - Burke, T. R. Jr. AU - Neamati, N. AU - Pommier, Y. AU - Merkel, G. AU - Skalka, A. M. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 9 SP - 4831 EP - 4836 SN - 0027-8424 AD - Lubkowski, J.: Macromolecular Structure Laboratory, Advanced BioScience Laboratories-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19982007306. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - The X-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-Å at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 integrase (HIV-1 IN), was found in this study to be active against ASV IN as well as HIV-1 IN. The Y-3 molecule is located in close proximity to the enzyme active site, interacts with the flexible loop, alters loop conformation, and affects the conformations of active site residues. As crystallized, a Y-3 molecule stacks against its symmetry-related mate. Preincubation of IN with metal cations does not prevent inhibition, and Y-3 binding does not prevent binding of divalent cations to IN. Three compounds chemically related to Y-3 also were investigated, but no binding was observed in the crystals. These results identify the structural elements of the inhibitor that likely determine its binding properties. KW - animal models KW - catalytic activity KW - human diseases KW - human immunodeficiency viruses KW - inhibition KW - inhibitors KW - integration KW - structure KW - birds KW - Human immunodeficiency virus 1 KW - Retroviridae KW - Rous sarcoma virus KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Alpharetrovirus KW - avian sarcoma virus KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication. AU - Grossman, Z. AU - Feinberg, M. B. AU - Paul, W. E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 11 SP - 6314 EP - 6319 SN - 0027-8424 AD - Grossman, Z.: The Office of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982008515. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - CD4+ T cell activation, required for virus replication in these cells, occurs in local microenvironmental domains in transient bursts. Thus, although most HIV originates from short-lived virus-producing cells, it is unlikely that chronic infection is generally sustained in rapid continuous cycles of productive infection as has been proposed. Such continuity of productive infection cycles would depend on efficient long-range transmission of HIV from one set of domains to another, in turn requiring the maintenance of sufficiently high concentrations of cell-free virus across lymphoid tissues at all times. By contrast, long-lived cellular sources of HIV maintain the capacity to infect newly activated cells at close range despite the temporal and spatial discontinuities of activation events. Such proximal activation and transmission (PAT) involving chronically and latently infected cells may be responsible for sustained infection, particularly when viral loads are low. Once CD4+ cells are productively infected through PAT, they can infect other activated cells in their immediate vicinity. Such events propagate locally but generally do not spread systemically, unlike in the acute phase of the infection, because of the early establishment of protective anergy. Importantly, antiretroviral drug treatment is likely to differentially impact long-range transmission and PAT. KW - antiviral agents KW - CD4 antigens KW - CD4+ lymphocytes KW - chronic course KW - concentration KW - culture media KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - infection KW - latent infections KW - lymphocyte transformation KW - pathogenesis KW - replication KW - T lymphocytes KW - transmission KW - treatment KW - viral replication KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - CD4+ cells KW - chemotherapy KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - T cells KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008515&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels. AU - Li-Smerin YingYing AU - Swartz, K. J. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 15 SP - 8585 EP - 8589 SN - 0027-8424 AD - Li-Smerin YingYing: Molecular Physiology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980506043. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 14127-61-8. Subject Subsets: Medical & Veterinary Entomology N2 - Hanatoxin and grammotoxin are related protein toxins found in the venom of the Chilean rose tarantula, Phrixotrichus spatulata. Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits voltage-gated Ca2+ channels. Both toxins inhibit their respective channels by interfering with normal operation of the voltage-dependent gating mechanism. The sequence homology of hanatoxin and grammotoxin, as well as their similar mechanism of action, raises the possibility that they interact with the same region of voltage-gated Ca2+ and K+ channels. It was shown that each toxin can interact with both voltage-gated Ca2+ and K+ channels and modify channel gating. Moreover, mutagenesis of voltage-gated K+ channels suggests that hanatoxin and grammotoxin recognize the same structural motif. It is proposed that these toxins recognize a voltage-sensing domain or module present in voltage-gated ion channels and that this domain has a highly conserved 3-d structure. KW - biochemistry KW - calcium ions KW - ion transport KW - molecular conformation KW - neurotoxicity KW - proteins KW - structure activity relationships KW - toxins KW - venoms KW - Arachnida KW - Theraphosidae KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Araneae KW - Arachnida KW - grammotoxin KW - hanatoxin KW - Phrixotrichus KW - Phrixotrichus spatulata KW - toxinology KW - venom KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506043&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection. AU - Chun TaeWook AU - Engel, D. AU - Berrey, M. M. AU - Shea, T. AU - Corey, L. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 15 SP - 8869 EP - 8873 SN - 0027-8424 AD - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA. N1 - Accession Number: 19982011099. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9007-49-2. N2 - The presence of latently infected, resting CD4+ T cells carrying replication-competent HIV-1 has been demonstrated in chronically infected individuals who are antiretroviral therapy naive as well as in those who are receiving highly active antiretroviral therapy (HAART). It is not clear, however, whether the establishment of a pool of latently infected CD4+ T cells can be blocked by early initiation of HAART after primary infection. This study demonstrates that initiation of HAART in infected individuals as early as 10 days after the onset of symptoms of primary HIV-1 infection did not prevent generation of latently infected, resting CD4+ T cells carrying integrated HIV-1 DNA as well as infectious HIV-1, despite the successful control of plasma viraemia shortly after institution of HAART. Furthermore, there was no correlation between either the duration of HAART at the time of study (range: 0.2-17 months) or the time of initiation of HAART after the onset of symptoms of primary HIV-1 infection (range: 0.3-4 months) and the frequencies of resting CD4+ T cells carrying either integrated HIV-1 DNA or infectious virus. These results underscore the rapidity with which latent reservoirs are established in primary HIV-1 infection and indicate that it is unlikely that early treatment during primary infection can prevent establishment of a pool of latently infected, resting CD4+ T cells as long as treatment is initiated after plasma viraemia becomes evident. KW - antiviral agents KW - blood plasma KW - CD4+ lymphocytes KW - DNA KW - drug therapy KW - human diseases KW - immunopathology KW - latent infections KW - pathogenesis KW - symptoms KW - treatment KW - viraemia KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4+ cells KW - chemotherapy KW - deoxyribonucleic acid KW - human immunodeficiency virus type 1 KW - immunopathogenesis KW - plasma (blood) KW - T4 lymphocytes KW - viremia KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011099&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. AU - Valentin, A. AU - Lu WenHong AU - Rosati, M. AU - Schneider, R. AU - Albert, J. AU - Karlsson, A. AU - Pavlakis, G. N. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 15 SP - 8886 EP - 8891 SN - 0027-8424 AD - Valentin, A.: Advanced BioScience Laboratories-Basic Research Program, Bldg 535, Rm 212, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982011100. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 207137-56-2. N2 - This study shows that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, increasing CXCR4 and decreasing CCR5 expression in primary CD4+ T-lymphocytes. In addition, IL-4 stimulates the expression of all HIV-1 isolates via a transcriptional activation mechanism. The combination of these effects results in increased propagation of CXCR4-using and inhibition of CCR5-using HIV-1 strains. IL-4 also activates HIV-1 expression in primary monocytes/macrophages but does not affect CCR5 expression. These results identify IL-4 as an important regulator of HIV-1 and suggest a critical role for this cytokine in the control of viral evolution and in the phenotypic switch from non-syncytia-inducing to syncytia-inducing, which leads to accelerated disease progression. KW - chemokines KW - cytokines KW - disease course KW - effects KW - human diseases KW - interleukin 4 KW - interleukins KW - pathogenesis KW - phenotypes KW - receptors KW - syncytia KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - disease progression KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011100&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. AU - Goldgur, Y. AU - Dyda, F. AU - Hickman, A. B. AU - Jenkins, T. M. AU - Craigie, R. AU - Davies, D. R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 16 SP - 9150 EP - 9154 SN - 0027-8424 AD - Goldgur, Y.: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982011102. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7439-95-4. N2 - Three additional crystal structures of the core domain of HIV-1 integrase mutants, crystallized in the presence and absence of cacodylate, as well as complexed with Mg2+, are reported. These 3 crystal forms, containing between them 7 independent core domain structures, demonstrate the unambigouous extension of the previously disordered helix α4 toward the amino terminus from residue M154 and show that the catalytic E152 points in the general direction of the two catalytic aspartates, D64 and D116. In the vicinity of the active site, the structure of the protein in the absence of cacodylate exhibits significant deviations from the previously reported structures. These differences can be attributed to the modification of C65 and C130 by cacodylate, which was an essential component of the original crystallization mixture. It was also demonstrated that, in the absence of cacodylate, this protein will bind to Mg2+, and could provide a satisfactory platform for binding of inhibitors. KW - binding KW - enzymes KW - human diseases KW - integration KW - magnesium KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - active site KW - human immunodeficiency virus type 1 KW - integrase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011102&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Footprints on the viral DNA ends in Moloney murine leukemia virus preintegration complexes reflect a specific association with integrase. AU - Wei ShuiQing AU - Mizuuchi, K. AU - Craigie, R. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 18 SP - 10535 EP - 10540 SN - 0027-8424 AD - Wei ShuiQing: Bldg 5, Rm 301, National Institute of Diabetes and Digestive and Kidney diseases, NIH, 5 Center Drive, MSC 0560, Bethesda, MD 20892-0560, USA. N1 - Accession Number: 19982013704. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 9007-49-2. N2 - Retroviral DNA integration is mediated by the preintegration complex, a large nucleoprotein complex derived from the core of the infecting virion. Mu-mediated PCR was previously used to probe the nucleoprotein organization of Moloney murine leukaemia virus preintegration complexes. A region of protection spans several hundred base pairs at each end of the viral DNA, and strong enhancements are present near the termini. The current study shows that these footprints reflect a specific association between integrase and the viral DNA ends in functional preintegration complexes. Barrier-to-autointegration factor, a cellular protein that blocks autointegration of Moloney murine leukaemia virus DNA, also plays an indirect role in generating the footprints at the ends of the viral DNA. Mu-mediated PCR was used to examine the effect of mutations at the viral DNA termini on complex formation. It was found that a replication competent mutant with a deletion at one end of the viral DNA still exhibits a strong enhancement about 20 bp from the terminus of the mutant DNA end. The site of the enhancement therefore appears to be at a fixed distance from the ends of the viral DNA. It was also found that a mutation at one end of the viral DNA, which renders the virus incompetent for replication, abolishes the enhancements and protection at both the U3 and U5 ends. A pair of functional viral DNA ends therefore is required to interact before the chemical step of 3′ end processing. KW - animal models KW - DNA KW - human diseases KW - integration KW - mutations KW - nucleoproteins KW - polymerase chain reaction KW - replication KW - mice KW - Murine leukemia virus KW - Retroviridae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - deoxyribonucleic acid KW - integrase KW - murine leukaemia virus KW - PCR KW - virions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013704&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reconstitution of HIV-1 Rev nuclear export: independent requirements for nuclear import and export. AU - Love, D. C. AU - Sweitzer, T. D. AU - Hanover, J. A. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 18 SP - 10608 EP - 10613 SN - 0027-8424 AD - Love, D. C.: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bldg 8, Rm 402, 8 Center Drive, Bethesda, MD 20892-0851, USA. N1 - Accession Number: 19982013705. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 56-65-5, 63231-63-0. N2 - Cell lines expressing a green fluorescent protein-labelled chimeric protein consisting of HIV-1 Rev and a hormone-inducible nuclear localization sequence were generated. Steroid removal switches off import thus allowing direct visualization of the Rev export pathway in living cells. After digitonin permeabilization of these cells, a functional nuclear export sequence (NES), ATP, and fractionated cytosol were sufficient for nuclear export in vitro. Nuclear pore-specific lectins and leptomycin B were potent export inhibitors. Nuclear export was not inhibited by antagonists of calcium metabolism that block nuclear import. These data further suggest that nuclear pores do not functionally close when luminal calcium stores are depleted. The distinct requirements for nuclear import and export argue that these competing processes may be regulated independently. This system should have wide applicability for the analysis of nuclear import and export. KW - ATP KW - cell lines KW - human diseases KW - in vitro KW - localization KW - proteins KW - Rev protein KW - RNA KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - adenosine triphosphate KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013705&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART. AU - Berger, E. A. AU - Moss, B. AU - Pastan, I. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 20 SP - 11511 EP - 11513 SN - 0027-8424 AD - Berger, E. A.: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Rm 236, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014288. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - The success of highly active anti-retroviral therapy (HAART) has inspired new concepts for eliminating HIV from infected individuals. A major obstacle is the persistence of long-lived reservoirs of latently infected cells that might become activated at some time after cessation of therapy. It is proposed that, in the context of treatment strategies to deliberately activate and eliminate these reservoirs, hybrid toxins targeted to kill HIV-infected cells be reconsidered in combination with HAART. Such combinations might also prove valuable in protocols aimed at preventing mother-to-child transmission and establishment of infection immediately after exposure to HIV. Experimental approaches in vitro and in animal models are suggested to test various issues related to safety and efficacy of this concept. KW - antiviral agents KW - combination therapy KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - toxins KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - combined modality therapy KW - human immunodeficiency virus KW - multimodal treatment KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014288&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reactivity of the HIV-1 nucleocapsid protein p7 zinc finger domains from the perspective of density-functional theory. AU - Maynard, A. T. AU - Huang, M. AU - Rice, W. G. AU - Covell, D. G. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 20 SP - 11578 EP - 11583 SN - 0027-8424 AD - Maynard, A. T.: Frederick Cancer Research and Development Center, National Cancer Institute, Science Applications International Corporation, Frederick, MD 21702, USA. N1 - Accession Number: 19982014289. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 7440-66-6. KW - human diseases KW - nucleocapsid proteins KW - structure KW - zinc KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014289&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 Tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes. AU - Weissman, J. D. AU - Brown, J. A. AU - Howcroft, T. K. AU - Hwang Jae AU - Chawla, A. AU - Roche, P. A. AU - Schiltz, L. AU - Nakatani, Y. AU - Singer, D. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 20 SP - 11601 EP - 11606 SN - 0027-8424 AD - Weissman, J. D.: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014290. Publication Type: Journal Article. Language: English. Number of References: 42 ref. N2 - These studies were designed to elucidate the mechanism of Tat repression and to identify any cellular factors with which Tat may interact in repressing MHC class I transcription. It is reported that Tat interacts with TAFII250, a component of the general transcription factor, TFIID, resulting in repression of MHC class I transcription in vitro. Tat binds to the histone acetyl transferase (HAT) domain of TafII250, inhibiting its activity. There was a correlation between promoter dependence on TAFII250 and susceptibility to Tat-mediated repression. These observations provide a possible mechanism for Tat repression through its binding to TAFII250. KW - gene expression KW - human diseases KW - major histocompatibility complex KW - pathogenesis KW - Tat protein KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - histocompatibility complex KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014290&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T cells: Role of signal transduction. AU - Kinter, A. AU - Catanzaro, A. AU - Monaco, J. AU - Ruiz, M. AU - Justement, J. AU - Moir, S. AU - Arthos, J. AU - Oliva, A. AU - Ehler, L. AU - Mizell, S. AU - Jackson, R. AU - Ostrowski, M. AU - Hoxie, J. AU - Offord, R. AU - Fauci, A. S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 20 SP - 11880 EP - 11885 SN - 0027-8424 AD - Kinter, A.: Bldg 10, Rm. 6A33, 10 Centre Dr., MSC-1576, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19982014291. Publication Type: Journal Article. Language: English. Number of References: 41 ref. N2 - This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signalling through inhibitory guanine nucleotide-binding regulatory (Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIV in vivo and suggest that the use of cell signalling CC-chemokines as therapeutic agents for the purpose of limiting HIV replication in vivo should be approached with caution. KW - chemokines KW - cytokines KW - human diseases KW - pathogenesis KW - T lymphocytes KW - tropisms KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014291&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesis. AU - Wang ZhenYuan AU - Wang, F. AU - Sellers, J. R. AU - Korn, E. D. AU - Hammer, J. A., III JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 26 SP - 15200 EP - 15205 SN - 0027-8424 AD - Wang ZhenYuan: Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990801631. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9064-37-3, 9000-83-3. Subject Subsets: Protozoology N2 - The actin-activated ATPase activity of Acanthamoeba myosin IC is stimulated 15- to 20-fold by phosphorylation of Ser-329 in the heavy chain. In most myosins, either glutamate or aspartate occupies this position, which lies within a surface loop that forms part of the actomyosin interface. To investigate the apparent need for a negative charge at this site, Ser-329 was mutated to alanine, asparagine, aspartate or glutamate, and the Flag-tagged wild-type or mutant heavy chain and light chain were co-expressed in baculovirus-infected insect cells. Recombinant wild-type myosin IC was indistinguishable from myosin IC purified from Acanthamoeba as determined by: the dependence of its actin-activated ATPase activity on heavy-chain phosphorylation; the unusual triphasic dependence of its ATPase activity on the concentration of F-actin; its Km for ATP; its ability to translocate actin filaments. The Ala and Asn mutants had the same low actin-activated ATPase activity as unphosphorylated wild-type myosin IC. The Glu mutant, like the phosphorylated wild-type protein, was 16-fold more active than unphosphorylated wild type, and the Asp mutant was 8-fold more active. The wild-type and mutant proteins had the same Km for ATP. Unphosphorylated wild-type protein and the Ala and Asn mutants were unable to translocate actin filaments, whereas the Glu mutant translocated filaments at the same velocity, and the Asp mutant at 50% the velocity, as phosphorylated wild-type proteins. It is concluded that an acidic amino acid can supply the negative charge in the surface loop required for the actin-dependent activities of Acanthamoeba myosin IC in vitro and that the length of the side chain that delivers this charge is important. Sequence data are available in the GenBank database under accession number AF051353. KW - actin KW - adenosinetriphosphatase KW - amino acid sequences KW - biochemistry KW - myosins KW - parasites KW - phosphorylation KW - Acanthamoeba KW - protozoa KW - Acanthamoebidae KW - Amoebida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - ATPase KW - myosin KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801631&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The JC and BK human polyoma viruses appear to be recent introductions to some South American Indian tribes: there is no serological evidence of cross-reactivity with the simian polyoma virus SV40. AU - Major, E. O. AU - Neel, J. V. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1998/// VL - 95 IS - 26 SP - 15525 EP - 15530 SN - 0027-8424 AD - Major, E. O.: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. N1 - Accession Number: 19992004044. Publication Type: Journal Article. Language: English. Number of References: 56 ref. N2 - Plasma samples collected during 1966-86 from 425 Amerindians representing 14 tribes from lower Central and northern South America were tested for haemagglutination inhibition antibodies to the human JC polyoma virus and from 369 Amerindians from 13 tribes for haemagglutination inhibition antibodies to the human BK polyoma virus. There is for both viruses highly significant heterogeneity between tribes for the prevalence of serum antibody titres ≥1/40, the pattern of infection suggesting that these 2 viruses only relatively recently have been introduced into some of these tribes. Some of these samples, from populations with no known exposure to the simian polyoma virus SV40, were also tested for antibodies to this virus by using an immunospot assay. None of the samples was found to possess antibodies to SV40. In addition, no significant titres to SV40 were found in a sample of 97 Japanese adults, many of whom had been found to exhibit elevated titres to the JC and BK viruses. It is suggested that these human sera contain significant antibody titres to the human polyoma viruses JC and BK but do not appear to contain either cross-reactive antibodies to SV40 or primary antibodies resulting from SV40 infection. KW - antibodies KW - cross reaction KW - epidemiology KW - ethnic groups KW - human diseases KW - seroprevalence KW - simian polyomaviruses KW - viral diseases KW - Central America KW - Japan KW - South America KW - BK polyomavirus KW - JC polyomavirus KW - man KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - JC virus KW - Polyomavirus hominis 1 KW - simian polyomavirus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004044&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain. AU - Smith, J. D. AU - Kyes, S. AU - Craig, A. G. AU - Fagan, T. AU - Hudson-Taylor, D. AU - Miller, L. H. AU - Baruch, D. I. AU - Newbold, C. I. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1998/// VL - 97 IS - 1/2 SP - 133 EP - 148 SN - 0166-6851 AD - Smith, J. D.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990801974. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Protozoology N2 - The A4VAR is a variant Plasmodium falciparum antigen expressed by a clonal line that binds CD36 and intercellular adhesion molecule 1 (ICAM-1). The extracellular domain coded by the A4var gene was cloned and sequenced. To probe the relationship between A4var expression and parasite adhesion to ICAM-1, var messenger RNA and protein expression were analysed in an enriched population of A4 parasites that displayed higher ICAM-1 binding. By Northern analyses, A4var was the predominant var message and antisera raised against a recombinant A4VAR protein reacted with the majority of infected erythrocytes, reinforcing previous conclusions that A4VAR binds ICAM-1. A4VAR contains 5 Duffy-binding like (DBL) domains and 2 cysteine-rich interdomain regions (CIDR) domains. DBL and CIDR domains from A4VAR were expressed in mammalian cells to determine which regions mediate binding to CD36 and ICAM-1. Using several different binding assays, the A4VAR CIDR1 was the only domain found to bind CD36. In contrast, the same assays were unable to identify the ICAM-1 binding domain in A4VAR. This is the first time that each of the DBL and CIDR domains from a P. falciparum erythrocyte membrane protein 1 (PfEMP1) have been systematically expressed and tested for binding. The results confirm that CIDR1 is sufficient to bind CD36 without any apparent contribution from other domains. Nucleotide sequence data have been submitted to the EMBL, GenBank and DDLJB databases under the accession number L42244. KW - antigens KW - binding proteins KW - biochemistry KW - cell membranes KW - clones KW - cytoadherence KW - erythrocytes KW - gene expression KW - genes KW - host parasite relationships KW - messenger RNA KW - molecular genetics KW - nucleotide sequences KW - parasites KW - proteins KW - variant surface glycoproteins KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - biochemical genetics KW - blood red cells KW - carrier proteins KW - cell adhesion KW - DNA sequences KW - immunogens KW - intercellular adhesion molecule 1 KW - mRNA KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801974&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary sources of nutrients among US adults, 1989 to 1991. AU - Subar, A. F. AU - Krebs-Smith, S. M. AU - Cook, A. AU - Kahle, L. L. JO - Journal of the American Dietetic Association JF - Journal of the American Dietetic Association Y1 - 1998/// VL - 98 IS - 5 SP - 537 EP - 547 SN - 0002-8223 AD - Subar, A. F.: National Cancer Institute, Applied Research Branch, 6130 Executive Blvd, MSC 7344, EPN 313, Bethesda, MD 20892-7344, USA. N1 - Accession Number: 19991408650. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition; Potatoes N2 - To identify major food sources of 27 nutrients and dietary constituents for US adults, single 24-h dietary recalls were used to assess intakes. From 3970 individual foods reported, 112 groups were created on the basis of similarities in nutrient content or use. Food mixtures were disaggregated using the US Department of Agriculture (USDA) food grouping system. A nationally representative sample of adults aged 19 years or older (n=10 638) from USDA's 1989-91 Continuing Survey of Food Intakes by Individuals. For each of 27 dietary components, the contribution of each food group to intake was obtained by summing the amount provided by the food group for all respondents and dividing by total intake from all food groups for all respondents. This article updates previous work and is, to the authors' knowledge, the first to provide such data for carotenes, vitamin B-12, magnesium, and copper. Beef, yeast bread, poultry, cheese, and milk were among the top 10 sources of energy, fat, and protein. The following other major sources also contributed more than 2% to energy intakes: carbohydrate: yeast bread, soft drinks/soda, cakes/cookies/quick breads/doughnuts, sugars/syrups/jams, potatoes (white), ready-to-eat cereal, and pasta; protein: pasta; and fat: margarine, salad dressings/mayonnaise, and cakes/ cookies/quick breads/doughnuts. Ready-to-eat cereals, primarily because of fortification, were among the top 10 food sources for 18 of 27 nutrients. These analyses are the most current regarding food sources of nutrients and, because of disaggregation of mixtures, provide a truer picture of contributions of each food group. KW - adults KW - diet studies KW - foods KW - nutrients KW - sources KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991408650&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection. AU - Sloand, E. M. AU - Maciejewski, J. P. AU - Sato, T. AU - Bruny, J. AU - Kumar, P. AU - Kim, S. AU - Weichold, F. F. AU - Young, N. S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 101 IS - 1 SP - 195 EP - 201 SN - 0021-9738 AD - Sloand, E. M.: Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19982004743. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9068-38-6. N2 - The role of interleukin-converting enzyme (ICE) in mediating the increased susceptibility of CD4+ lymphocytes from HIV-1-infected patients to apoptosis was investigated. ICE mRNA was present in T cells from both HIV-1-infected patients (n=40) and controls. Active ICE proteins, p10 and p20, were demonstrated by immunoblot in lymphocytes from HIV-1-infected patients and in normal lymphocytes after treatment with Fas agonist, CH11 monoclonal antibody. Cocultivation of lymphocytes from HIV-1-infected persons with Fas antagonist, antibody ZB4, resulted in decreased expression of ICE protein in lymphocytes from HIV-infected patients, and decreased apoptosis. Similar effects were obtained when cells were treated with synthetic ICE inhibitors, which blocked apoptosis in response to Fas triggering. When CD4+ and CD8+ cells were sorted by flow cytometry and analysed by reverse transcriptase PCR, ICE mRNA was present in both CD8- and CD4+ cells. However, flow cytometric analysis of lymphocytes with intracellular staining for ICE demonstrated ICE protein in the CD4+ but not the CD8+ cell fraction derived from blood of HIV-1-infected patients. These data suggest that activation of ICE occurs in vivo in CD4+ lymphocytes from HIV-1-infected individuals, and may account for the increased susceptibility of CD4+ cells to apoptosis. KW - acquired immune deficiency syndrome KW - antibodies KW - apoptosis KW - culture techniques KW - enzymes KW - flow cytometry KW - HIV-1 infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunoblotting KW - immunopathology KW - interleukin 1 KW - messenger RNA KW - pathogenesis KW - patients KW - reverse transcriptase KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - interleukin-converting enzyme KW - mRNA KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004743&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A phase I/II study of the protease inhibitor ritonavir in children with human immunodeficiency virus infection. AU - Mueller, B. U. AU - Nelson, R. P., Jr. AU - Sleasman, J. AU - Zuckerman, J. AU - Heath-Chiozzi, M. AU - Steinberg, S. M. AU - Balis, F. M. AU - Brouwers, P. AU - Hsu, A. AU - Saulis, R. AU - Sei, S. AU - Wood, L. V. AU - Zeichner, S. AU - Katz, T. T. K. AU - Higham, C. AU - Aker, D. AU - Edgerly, M. AU - Jarosinski, P. AU - Serchuck, L. AU - Whitcup, S. M. AU - Pizzuti, D. AU - Pizzo, P. A. JO - Pediatrics JF - Pediatrics Y1 - 1998/// VL - 101 IS - 3 SP - 335 EP - 343 SN - 0031-4005 AD - Mueller, B. U.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland. N1 - Accession Number: 19992000040. Publication Type: Journal Article. Language: English. Registry Number: 69655-05-6, 63231-63-0, 30516-87-1. N2 - Ritonavir, a potent antiretroviral protease inhibitor, has been approved for the treatment of adults and children with human immunodeficiency virus (HIV) infection. In a phase I/II study, we assessed the safety, tolerability, and pharmacokinetic profile of the oral solution of ritonavir in HIV-infected children and studied the preliminary antiviral and clinical effects. HIV-infected children between 6 months and 18 years of age were eligible. Four dose levels of ritonavir oral solution (250, 300, 350, and 400 mg/m² given every 12 hours) were evaluated in two age groups (≤2 years, >2 years). Ritonavir was administered alone for the first 12 weeks and then in combination with zidovudine and/or didanosine. Clinical and laboratory parameters were monitored every 2 to 4 weeks. A total of 48 children (median age, 7.7 years; range, 0.5 to 14.4 years) were included in this analysis. Dose-related nausea, diarrhoea, and abdominal pain were the most common toxicities and resulted in discontinuation of ritonavir in 7 children. Ritonavir was well absorbed at all dose levels, and plasma concentrations reached a peak 2 to 4 hours after a dose. CD4 cells counts increased by a median of 79 cells/mm³ after 4 weeks of monotherapy and were maintained throughout the study. Plasma HIV RNA decreased by 1 to 2 log10 copies/mL within 4 to 8 weeks of ritonavir monotherapy, and this level was sustained in patients enrolled at the highest dose level of 400 mg/m² for the 24-week period. The oral solution of ritonavir has potent antiretroviral activity as a single agent and is relatively well tolerated by children when administered alone or in combination with zidovudine or didanosine. KW - acquired immune deficiency syndrome KW - antiviral agents KW - blood plasma KW - CD4 antigens KW - CD4+ lymphocytes KW - children KW - clinical aspects KW - concentration KW - diarrhoea KW - didanosine KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - laboratories KW - patients KW - proteinase inhibitors KW - proteinases KW - RNA KW - safety KW - treatment KW - zidovudine KW - man KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - AZT KW - CD4 KW - CD4+ cells KW - clinical picture KW - diarrhea KW - dideoxyinosine KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - plasma (blood) KW - protease inhibitors KW - proteases KW - ribonucleic acid KW - scouring KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Occupational Health and Safety (VV900) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Virulence of catalase-deficient Aspergillus nidulans in p47phox-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease. AU - Chang, Y. C. AU - Segal, B. H. AU - Holland, S. M. AU - Miller, G. F. AU - Kown-Chung, K. J. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 101 IS - 9 SP - 1843 EP - 1850 SN - 0021-9738 AD - Chang, Y. C.: Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201886. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9001-05-2. Subject Subsets: Medical & Veterinary Mycology N2 - To test the role of pathogen-derived catalase in chronic granulomatous disease (CGD) directly, isogenic strains of A. nidulans were generated in which one or both of the catalase genes (catA and catB), were deleted. It was hypothesized that catalase-negative mutants would be less virulent than the wild-type strain in experimental animal models. CGD mice were produced by disruption of the p47phox gene, which encodes the 47-kDa subunit of the NADPH oxidase. Wild-type A. nidulans inoculated intranasally caused fatal infection in CGD mice, but did not cause disease in wild-type littermates. Wild-type A. nidulans and the catA, catB and catA/catB mutants were equally virulent in CGD mice. Histopathological studies of fatally infected CGD mice showed widely distributed lesions in the lungs regardless of the presence or absence of the catA and catB genes. Similar to the CGD model, catalase-deficient A. nidulans was highly virulent in cortisone-treated BALB/c mice. These results indicated that catalases do not play a significant role in pathogenicity of A. nidulans in p47phox-/- mice. KW - aspergillosis KW - catalase KW - enzymes KW - experimental infections KW - genes KW - genetics KW - immunological diseases KW - infections KW - pathogenicity KW - susceptibility KW - virulence KW - Emericella nidulans KW - mice KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Emericella KW - Aspergillus nidulans KW - erythrocyte catalase KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201886&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts. AU - Mott, D. M. AU - Pratley, R. E. AU - Bogardus, C. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 101 IS - 10 SP - 2251 EP - 2256 SN - 0021-9738 AD - Mott, D. M.: Clinical Diabetes & Nutrition Section, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19981410885. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 50-99-7, 9014-56-6, 9004-10-8. Subject Subsets: Human Nutrition N2 - Glycogen synthase fractional activity (GSFA) was measured in cultured myoblasts from 21 Pima Indians (12 men and 9 women aged 30±6 years) characterized in vivo using indirect calorimetry and a euglycaemic hyperinsulinaemic clamp. Basal GSFA in cultured muscle cells was inversely correlated with postabsorptive respiratory quotient of the muscle donors (r = -0.66, P=0.001) and with in vivo high dose insulin-stimulated glucose storage rates (r = 0.47, P=0.04). It is concluded that the postabsorptive respiratory quotients and insulin-mediated glucose storage rates in vivo share a common regulatory mechanism with GSFA in cultured myoblasts. Abnormal regulation of glycogen synthase phosphorylation state may be an intrinsic defect in skeletal muscle associated with obesity and insulin resistance. KW - blood sugar KW - cell cultures KW - diabetes KW - enzymes KW - ethnic groups KW - glucose KW - glucose tolerance KW - glycogen (starch) synthase KW - in vitro KW - insulin KW - metabolism KW - obesity KW - respiratory quotient KW - skeletal muscle KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood glucose KW - blood sugar tolerance KW - dextrose KW - fatness KW - glucose in blood KW - glycogen synthase KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981410885&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mutation in the signal-transducing chain of the interferon-γ receptor and susceptibility to mycobacterial infection. AU - Dorman, S. E. AU - Holland, S. M. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 101 IS - 11 SP - 2364 EP - 2369 SN - 0021-9738 AD - Dorman, S. E.: Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886, USA. N1 - Accession Number: 19982010844. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9008-11-1. Subject Subsets: Public Health KW - bacterial diseases KW - case reports KW - clinical aspects KW - disseminated infections KW - human diseases KW - immune response KW - immunocompromised hosts KW - interferon KW - mutations KW - mycobacterial diseases KW - receptors KW - Maryland KW - USA KW - man KW - Mycobacterium KW - Mycobacterium avium KW - Mycobacterium fortuitum KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - clinical picture KW - immunity reactions KW - immunological reactions KW - mycobacterial infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010844&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A phase I/II study of the protease inhibitor indinavir in children with HIV infection. AU - Mueller, B. U. AU - Sleasman, J. AU - Nelson, R. P. Jr AU - Smith, S. AU - Deutsch, P. J. AU - Ju, W. AU - Steinberg, S. M. AU - Balis, F. M. AU - Jarosinski, P. F. AU - Brouwers, P. AU - Mistry, G. AU - Winchell, G. AU - Zwerski, S. AU - Sei, S. AU - Wood, L. V. AU - Zeichner, S. AU - Pizzo, P. A. JO - Pediatrics JF - Pediatrics Y1 - 1998/// VL - 102 IS - 1 SP - 101 EP - 109 SN - 0031-4005 AD - Mueller, B. U.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19982012304. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 63231-63-0, 30516-87-1, 150378-17-9. N2 - Three dose levels (250 mg/m², 350 mg/m², and 500 mg/m² per dose given orally every 8 h) were evaluated in 2 age groups (<12 years and ≥12 years). Indinavir was initially administered as monotherapy and then in combination with zidovudine and lamivudine after 16 weeks. Fifty four HIV-infected children (ages 3.1 to 18.9 years) were enrolled. The indinavir free-base suspension was less bioavailable than the dry-filled capsule formulation, and therapy was changed to capsules in all children. Haematuria was the most common side effect, occurring in 7 (13%) children, and associated with nephrolithiasis in 1 patient. The combination of indinavir, lamivudine, and zidovudine was well tolerated. The median CD4+ cell count increased after 2 weeks of indinavir monotherapy by 64 cells/mm³, and this was sustained at all dose levels. Plasma ribonucleic acid levels decreased rapidly in a dose-dependent way, but increased toward baseline after a few weeks of indinavir monotherapy. Indinavir dry-filled capsules are relatively well tolerated by children with HIV infection, although haematuria occurs at higher doses. Future studies need to evaluate the efficacy of indinavir when combined de novo with zidovudine and lamivudine. KW - antiviral agents KW - CD4+ lymphocytes KW - children KW - clinical trials KW - combination therapy KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - indinavir KW - leukocyte count KW - proteinase inhibitors KW - RNA KW - safety KW - toxicity KW - treatment KW - zidovudine KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - CD4+ cells KW - cell count KW - chemotherapy KW - combined modality therapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - multimodal treatment KW - protease inhibitors KW - ribonucleic acid KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012304&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro. AU - Oliva, A. AU - Kinter, A. L. AU - Vaccarezza, M. AU - Rubbert, A. AU - Catanzaro, A. AU - Moir, S. AU - Monaco, J. AU - Ehler, L. AU - Mizell, S. AU - Jackson, R. AU - Li YueXia AU - Romano, J. W. AU - Fauci, A. S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 102 IS - 1 SP - 223 EP - 231 SN - 0021-9738 AD - Oliva, A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC-1576, Bethesda, MD 20892, USA. N1 - Accession Number: 19982012271. Publication Type: Journal Article. Language: English. Number of References: 58 ref. N2 - Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES (regulated on activation, normal T cell expressed and secreted), which are the natural ligands of the CC-chemokine receptor CCR5, inhibit replication of MT-2-negative strains of HIV-1 by interfering with the ability of these strains to utilize CCR5 as a coreceptor for entry in CD4+ cells. This study investigates the capacity of natural killer (NK) cells isolated from HIV-infected individuals to produce CC-chemokines and to suppress HIV replication in autologous, endogenously infected cells as well as to block entry of MT-2-negative HIV into the CD4+ T cell line PM-1. NK cells freshly isolated from HIV-infected individuals had a high number of mRNA copies for MIP-1α and RANTES. NK cells produced significant amounts of RANTES, MIP-1α, and MIP-1β constitutively, in response to stimulation with IL-2 alone and when they were performing their characteristic lytic activity (K562 killing). After CD16 cross-linking and stimulation with IL-2 or IL-15 NK cells produced CC-chemokines to levels comparable to those produced by anti-CD3-stimulated CD8+ T cells. Furthermore, CD16 cross-linked NK cells suppressed (49-97%) viral replication in cocultures of autologous CD8/NK-depleted PBMC to a degree similar to that of PHA or anti-CD3-stimulated CD8+ T cells. In 50% of patients tested, NK-mediated HIV suppression could be abrogated by neutralizing antibodies to MIP-1α, MIP-1β and RANTES; in contrast, CD8+ T cell-mediated suppression was not significantly overcome upon neutralization of CC-chemokines. Supernatants derived from cultures of CD16 cross-linked NK cells stimulated with IL-2 or IL-15 dramatically inhibited entry of a MT-2-negative strain of HIV, BaL, in the CD4+ CCR5+ PM-1 T-cell line. These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms. KW - chemokines KW - cytokines KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - in vitro KW - natural killer cells KW - replication KW - uptake KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis C virus infection in the mothers and infants cohort study. AU - Granovsky, M. O. AU - Minkoff, H. L. AU - Tess, B. H. AU - Waters, D. AU - Hatzakis, A. AU - Devoid, D. E. AU - Landesman, S. H. AU - Rubinstein, A. AU - Bisceglie, A. M. di AU - Goedert, J. J. JO - Pediatrics JF - Pediatrics Y1 - 1998/// VL - 102 IS - 2 SP - 355 EP - 359 SN - 0031-4005 AD - Granovsky, M. O.: Division of Cancer Epidemiology and Genetics, Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992000129. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 63231-63-0. N2 - The objective was to estimate the hepatitis C virus (HCV) vertical transmission rate, the effect of potential risk factors, and the pattern of HCV antibody response and viraemia in HCV-infected infants. The Mothers and Infants Cohort Study enrolled both human immunodeficiency virus (HIV)-seropositive and HIV-seronegative pregnant women at 5 obstetric clinics in New York City, USA in a prospective cohort study between January 1986 and January 1991. HCV-infected mothers and their 122 offspring were followed up for a minimum of 12 months for evidence of HCV infection as determined by persistent HCV antibodies or detection of HCV RNA by reverse transcription polymerase chain reaction. Comparisons among groups for categorical variables were performed using the Fisher's exact test. Seven (6%; 95% confidence interval, 2%-11%) of the 122 infants were HCV-infected. There was a tendency for increased risk of transmission with maternal viral and obstetrical factors, such as co-infection with HIV (7% vs 4%), high HIV viral load (13% vs 6%), HCV viraemia (8% vs 3%), vaginal delivery (6% vs 0%), and female gender of offspring (8% vs 3%), although none of the associations reached statistical significance. After loss of maternal antibody, HCV antibody seroconversion occurred at a mean age of 26 months in 3 HIV-co-infected infants compared with 7 months of age in 4 HCV-infected HIV-negative infants. Serial samples showed that HCV RNA persisted in 6 infants for at least 18 to 54 months. It is concluded that this study is in accordance with other studies that have shown low overall HCV vertical transmission risk and a trend toward higher risk with maternal risk factors such as HIV-co-infection or HCV viraemia. A delay in infant HCV antibody response may be associated with HIV co-infection although larger studies are needed to confirm these findings. KW - antibodies KW - detection KW - hepatitis C KW - human diseases KW - human immunodeficiency viruses KW - infants KW - infection KW - maternal antibodies KW - maternal transmission KW - mothers KW - polymerase chain reaction KW - pregnancy KW - risk factors KW - RNA KW - seroconversion KW - statistics KW - transcription KW - transmission KW - vertical transmission KW - women KW - New York KW - USA KW - hepatitis C virus KW - man KW - viruses KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - DNA transcription KW - gestation KW - human immunodeficiency virus KW - mother to child transmission KW - PCR KW - ribonucleic acid KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000129&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes. AU - Ueda, H. AU - Howard, O. M. Z. AU - Grimm, M. C. AU - Su ShaoBo AU - Gong WangHua AU - Evans, G. AU - Ruscetti, F. W. AU - Oppenheim, J. J. AU - Wang JiMing JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 102 IS - 4 SP - 804 EP - 812 SN - 0021-9738 AD - Ueda, H.: Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Room 31-40, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982013233. Publication Type: Journal Article. Language: English. Number of References: 49 ref. N2 - Monocytes preincubated with gp41 of the MN strain showed markedly reduced binding, calcium mobilization, and chemotaxis in response to a variety of chemokines as well as to the bacterial peptide fMLP. This generalized inhibition of monocyte activation by chemoattractants required the presence of CD4, since the effect of gp41 was only observed in CD4+ monocytes and in HEK293 cells cotransfected with chemokine receptors and an intact CD4, but not a CD4 lacking its cytoplasmic domain. Confocal microscopy showed that gp41 caused internalization of CXCR4 in HEK293 cells provided they were also cotransfected with intact CD4. In addition, pretreatment of monocytes with protein kinase C inhibitors partially reversed the inhibitory effect of gp41. Thus, gp41, which had not previously been implicated as interacting with HIV-1 fusion cofactors, downregulates chemoattractant receptors on monocytes by a CD4-dependent pathway. KW - chemokines KW - chemotaxis KW - cytokines KW - envelope protein gp41 KW - human diseases KW - monocytes KW - pathogenesis KW - receptors KW - suppression KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - gp41 KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013233&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary sources of nutrients among US children, 1989-1991. AU - Subar, A. F. AU - Krebs-Smith, S. M. AU - Cook, A. AU - Kahle, L. L. JO - Pediatrics JF - Pediatrics Y1 - 1998/// VL - 102 IS - 4 SP - 913 EP - 923 SN - 0031-4005 AD - Subar, A. F.: National Cancer Institute, Applied Research Branch, Bethesda, Maryland, USA. N1 - Accession Number: 19981417763. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 50-81-7, 59-30-3, 7439-89-6, 68-26-8, 7440-66-6. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts; Potatoes N2 - 24-h dietary recalls were collected from a nationally representative sample of children (n=4008; 2 to 18 years old) from the US Department of Agriculture's 1989-1991 Continuing Survey of Food Intakes by Individuals. For each of 16 dietary constituents, the contribution of each of 113 food groups was obtained by summing the amount provided by the food group for all individuals and dividing by total intake from all food groups for all individuals. Milk, yeast bread, cakes/cookies/quick breads/doughnuts, beef and cheese were among the top 10 sources of energy, fat and protein. Many of the top 10 sources of carbohydrate (yeast bread, soft drinks/sodas, milk, ready-to-eat cereal, cakes/cookies/quick breads/doughnuts, sugars/syrups/jams, fruit drinks, pasta, white potatoes); protein (poultry, ready-to-eat cereal, pasta); and fat (potato chips/corn chips/popcorn) also contributed >2% each to energy intakes. Ready-to-eat cereal was among the top contributors to folate, vitamin A, vitamin C, iron and zinc intakes. Fruit drinks, containing little juice, contributed ~14% of total vitamin C intakes. It was concluded that fortified foods were influential contributors to many vitamins and minerals. Low nutrient-dense foods were major contributors to energy, fats and carbohydrate. This compromises the intake of more nutritious foods and may impede compliance with current dietary guidance. KW - ascorbic acid KW - carbohydrates KW - cereal products KW - children KW - diet KW - diet studies KW - energy intake KW - fat KW - folic acid KW - foods KW - fortification KW - guidelines KW - iron KW - protein KW - retinol KW - trace elements KW - vitamins KW - zinc KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - folacin KW - folate KW - microelements KW - recommendations KW - saccharides KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417763&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1. AU - Moriuchi, M. AU - Moriuchi, H. AU - Turner, W. AU - Fauci, A. S. JO - Journal of Clinical Investigation JF - Journal of Clinical Investigation Y1 - 1998/// VL - 102 IS - 8 SP - 1540 EP - 1550 SN - 0021-9738 AD - Moriuchi, M.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19992000718. Publication Type: Journal Article. Language: English. Number of References: 83 ref. N2 - Whether exposure of macrophages to bacterial products impacts the susceptibility of these cells to HIV-1 of different cellular tropisms was examined. it is demonstrated that (1) macrophages exposed to bacterial cell wall components such as lipopolysaccharide (LPS) (Gram-negative rods), lipoteichoic acid (Gram-positive cocci), and lipoarabinomannan (Mycobacteria) become highly susceptible to T cell (T)-tropic HIV-1 (which otherwise poorly replicate in macrophages) and variably susceptible to macrophage (M)-tropic HIV-1; (2) LPS-stimulated macrophages secrete a number of soluble factors (i.e., chemokines, interferon, and proinflammatory cytokines) that variably affect HIV infection of macrophages, depending on the virus phenotype in question; and (3) LPS-stimulated macrophages express CCR5 (a major coreceptor for M-tropic HIV-1) at lower levels and CXCR4 (a major coreceptor for T-tropic HIV-1) at higher levels compared with unstimulated macrophages. It is hypothesized that a more favourable environment for T-tropic HIV-1 and a less favourable or even unfavourable environment for M-tropic HIV-1 secondary to exposure of macrophages to those bacterial products may accelerate a transition from M- to T-tropic viral phenotype, which is indicative of disease progression. KW - bacterial products KW - exposure KW - macrophages KW - pathogenesis KW - susceptibility KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000718&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. AU - Termanini, B. AU - Gibril, F. AU - Sutliff, V. E. AU - Fang Yu AU - Venzon, D. J. AU - Jensen, R. T. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1998/// VL - 104 IS - 5 SP - 422 EP - 430 SN - 0002-9343 AD - Termanini, B.: Digestive Diseases Branch, National Institute of Diabetes, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19981412734. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Registry Number: 9000-83-3, 68-19-9. Subject Subsets: Human Nutrition N2 - This study examined whether long-term treatment with omeprazole (a H+-K+-adenotriphosphatase (ATPase) inhibitor) alters serum vitamin B12 concentrations in patients with Zollinger-Ellison syndrome. 131 consecutive patients treated with either omeprazole (n=111) or histamine H2-receptor antagonists (n=20) were recruited. Serum vitamin B12 and folate concentrations and complete blood counts were determined after acid secretion had been controlled for at least 6 months. These studies were repeated yearly. Serum vitamin B12 and folate concentrations were correlated with the type of antisecretory drug and the extent of inhibition of acid secretion. The mean duration of omeprazole treatment was 4.5 years, and for H2-receptor antagonists 10 years. Vitamin B12 concentrations, but not serum folate concentrations or any haematological parameter, were lower (P=0.03) in patients treated with omeprazole, especially those with omeprazole-induced sustained hyposecretion (P=0.0014) or complete achlorhydria (P<0.0001). In 68 patients with 2 determinations at least 5 years apart, vitamin B12 concentrations decreased (30%; P=0.001) only in patients rendered achlorhydric. The duration of omeprazole treatment was inversely correlated with vitamin B12 concentrations (P=0.013), but not folate concentrations. Eight patients (6%) developed subnormal B12 concentrations during follow-up. It was concluded that long-term omeprazole treatment leads to significant decreases in serum vitamin B12 but not folate concentrations. These results suggest patients with Zollinger-Ellison syndrome treated with H+-K+-ATPase inhibitors should have their serum vitamin B12 concentrations monitored. Furthermore, these results raise the possibility that other patients treated chronically with H+-K+-ATPase inhibitors may develop B12 deficiency. KW - adenosinetriphosphatase KW - cyanocobalamin KW - drug therapy KW - gastric acid KW - inhibition KW - nutritional state KW - patients KW - serum KW - therapy KW - vitamin B12 KW - Zollinger-Ellison syndrome KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ATPase KW - chemotherapy KW - cobalamin KW - nutritional status KW - therapeutics KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412734&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A randomized comparison of fluconazole with amphotericin B as empiric anti-fungal agents in cancer patients with prolonged fever and neutropenia. AU - Malik, I. A. AU - Moid, I. AU - Aziz, Z. AU - Khan, S. AU - Suleman, M. JO - American Journal of Medicine JF - American Journal of Medicine Y1 - 1998/// VL - 105 IS - 6 SP - 478 EP - 483 SN - 0002-9343 AD - Malik, I. A.: Department of Medical Oncology, National Cancer Institute, Karachi, Pakistan. N1 - Accession Number: 19991200438. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 1397-89-3, 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - A total of 106 patients from Pakistan [date not given] with absolute neutropenia (≤500 cells µl) and persistent fever of undetermined origin (>38°C) despite 1 week of broad-spectrum antibiotic therapy were randomly assigned to receive either fluconazole 400 mg orally daily or amphotericin B 0.5 mg/kg daily. Patients with obvious invasive fungal infections were excluded, as were those with abnormal renal or hepatic function. Success was defined as defervescence with the initially assigned antifungal regimen without development of clinically evident invasive fungal infection. Six patients were excluded from the analysis, mostly because they did not have severe neutropenia. 48 patients received amphotericin B and 52 received fluconazole. Baseline clinical characteristics and laboratory parameters as well as duration of neutropenia (7.7 vs. 6.9 days), duration of fever (7.8 vs. 8.1 days) and duration of hospitalization (10.4 vs. 8.3 days) were similar between those receiving amphotericin and fluconazole. Treatment success rates and mortality rates were similar in the 2 groups: 22 (46%) patients in the amphotericin group and 29 (56%) in the fluconazole group responded successfully to therapy (P=0.3), whereas 16 (33%) patients in the amphotericin group and 14 (27%) in the fluconazole group died during hospitalization (P=0.5). Adverse events such as chills and fever (4 vs. 1), bronchospasm (2 vs. 0), severe hypokalaemia (25 vs. 12) and nephrotoxicity (9 vs. 3) were more frequently observed in patients receiving amphotericin. Adverse prognostic factors included prolonged duration of neutropenia and pneumonia. It is concluded that fluconazole is an equally effective but less toxic alternative to amphotericin B as empiric antifungal therapy in cancer patients with prolonged fever and neutropenia. KW - adverse effects KW - amphotericin B KW - efficacy KW - fluconazole KW - human diseases KW - immunocompromised hosts KW - mycoses KW - neoplasms KW - neutropenia KW - opportunistic infections KW - predisposition KW - prophylaxis KW - Pakistan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - adverse reactions KW - cancers KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200438&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 2,3,7,8-tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. AU - Landi, M. T. AU - Consonni, D. AU - Patterson, D. G., Jr. AU - Needham, L. L. AU - Lucier, G. AU - Brambilla, P. AU - Cazzaniga, M. A. AU - Mocarelli, P. AU - Pesatori, A. C. AU - Bertazzi, P. A. AU - Caporaso, N. E. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1998/// VL - 106 IS - 5 SP - 273 EP - 277 SN - 0091-6765 AD - Landi, M. T.: Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 USA. N1 - Accession Number: 19992007323. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into 3 zones (A, B, R) corresponding to decreasing TCDD levels in soil, and a cohort including all residents was enumerated. The population of the surrounding non-contaminated area (non-ABR) was chosen as referent population. Two decades after the accident, plasma TCDD levels were measured in 62 subjects randomly sampled from the highest exposed zones (A and B) and 59 subjects from non-ABR, frequency matched for age, gender and cigarette smoking status. Subjects living in the exposed areas had persistently elevated plasma TCDD levels (range=1.2-89.9 ppt; geometric mean=53.2 and 11.0 ppt for Zone A and Zone B, respectively). Levels significantly decrease by distance from the accident site (P=0.0001), down to general population values (4.9 ppt) in non-ABR, thus validating the original zone classification based on environmental measurements. Women had higher TCDD levels than men in the entire study area (P=0.0003 in Zone B; P=0.007 in non-ABR). This gender difference persists after adjustment for location within the zone, consumption of meat derived from locally raised animals, age, body mass index and smoking. There is no evidence for a gender difference in exposure, so variation in metabolism or elimination due to body fat or hormone-related factors may explain this finding. Elevated TCDD levels in women may contribute to adverse reproductive, developmental and cancer outcomes. KW - blood KW - contamination KW - dioxins KW - heterocyclic oxygen compounds KW - poisoning KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - toxicosis KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007323&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hexachlorobenzene as a possible major contributor to the dioxin activity of human milk. AU - Birgelen, A. P. J. M. van JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1998/// VL - 106 IS - 11 SP - 683 EP - 688 SN - 0091-6765 AD - Birgelen, A. P. J. M. van: National Institute of Environmental Health Sciences, P.O. Box 12233, MD B3-07, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19990404034. Publication Type: Journal Article. Language: English. Number of References: 100 ref. Registry Number: 118-74-1. Subject Subsets: Human Nutrition; Dairy Science N2 - A dioxin-like compound is a compound that binds to the aryl hydrocarbon (Ah) receptor, results in dioxin-like effects, and bioaccumulates. These are the 3 factors for including dioxin-like chemicals in the toxic equivalency factor (TEF) concept. Risk assessment of dioxin-like compounds is based on using these TEF. Hexachlorobenzene (HCB) has all 3 features and should therefore be included in the TEF concept. Relative potency values express the potency of a specific compound in comparison to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent dioxin-like compound, with a relative potency value of 1. For the estimation of the total dioxin activity in an environmental biological sample, the TEF value of a compound is multiplied by the concentration in the specific matrix. This results in a certain number of toxic equivalents (TEQ) for this compound. The total of all TEQ in a certain mixture gives the total dioxin activity of this mixture. HCB binds to the Ah receptor approximately 10 000 times less than TCDD. HCB is also about 10 000 times less potent than TCDD based on in vitro cytochrome P4501A induction and porphyrin accumulation. Using a relative potency value of 0.0001, HCB could add 10-60% to the total TEQ in human milk samples in most countries. In a few countries such as Spain, Slovakia, and the Czech Republic, HCB levels in human milk expressed as TEQ could contribute up to a factor of 6 to the total TEQ in comparison to the contribution of polychlorinated dioxins, dibenzofurans, and biphenyls together, i.e. up to a daily intake of approximately 1 ng TEQ/kg for a breast-fed infant. The HCB levels in human milk in these countries are about the same as those in India. Biochemical, immunological, and neurological changes have been observed in breast-fed infants in countries with relatively low TEQ levels in human milk. Based on this information, the author concludes that HCB should be classified as a dioxin-like compound, that more studies are needed to reduce the uncertainty in the estimation of a relative potency value for HCB, and that epidemiological studies should be undertaken in infants breast-fed in countries with high HCB exposure levels. Furthermore, measurements of HCB levels in human and environmental samples in conjunction with other dioxin-like compounds are a prerequisite for estimating the total dioxin activity in these samples. KW - breast feeding KW - dioxins KW - epidemiology KW - hexachlorobenzene KW - human milk KW - infants KW - measurement KW - polychlorinated biphenyls KW - polychlorinated dibenzodioxins KW - polychlorinated dibenzofurans KW - reviews KW - Czech Republic KW - India KW - Slovakia KW - Spain KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - Mediterranean Region KW - Southern Europe KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin KW - aryl hydrocarbon KW - breast milk KW - HCB KW - metrology KW - PCBs KW - polychlorinated dioxins KW - porphyrin KW - toxic equivalents KW - Milk and Dairy Produce (QQ010) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990404034&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Comparison of pesticides and other compounds in carpet dust samples collected from used vacuum cleaner bags and from a high-volume surface sampler. AU - Colt, J. S. AU - Zahm, S. H. AU - Camann, D. E. AU - Hartge, P. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1998/// VL - 106 IS - 11 SP - 721 EP - 724 SN - 0091-6765 AD - Colt, J. S.: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Boulevard, Room 418, Bethesda, MD 20892-7364, USA. N1 - Accession Number: 19990505054. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4, 90-43-7, 63-25-2, 57-74-9, 12789-03-6, 2921-88-2, 72-55-9, 50-29-3, 72-43-5, 87-86-5, 52645-53-1, 114-26-1. Subject Subsets: Medical & Veterinary Entomology; Weeds N2 - Epidemiologic studies of the association between residential pesticide use and cancer risk require an assessment of past pesticide exposures. Pesticide levels in carpet dust are believed to reflect long-term pesticide use. Recent epidemiologic studies have found collection of dust samples using the high-volume surface sampler (HVS3) to be expensive and cumbersome. The levels of pesticides and other compounds in dust obtained from subjects' personal used vacuum cleaner bags were compared to that collected by the HVS3 to see if this simpler method could replace the HVS3 in epidemiologic research. The homes of 15 subjects were visited, used bags taken from their vacuum cleaners, and carpet dust samples collected with the HVS3. The samples were analysed for 42 target compounds: 26 pesticides including DDT, DDE, methoxychlor, chlordane, chlopyrifos, propoxur, carbaryl, permethrin, 2-phenylphenol, pentachlorophenol and 2,4-D, 10 polycyclic aromatic hydrocarbons (PAHs), and 6 polychlorinated biphenyl (PCB) congeners using GC/MS in selected ion monitoring mode. The 2 methods agreed in detecting the presence of the target compounds between 80% and 100% of the time. Neither sampling method was consistently more sensitive. The median target compound concentrations were similar, and a paired t-test showed no significant differences. For many compounds, the concentrations of compounds in the HVS3 samples were higher than those in the used bag samples at the upper end of the concentration ranges. However, the Spearman rank correlation coefficients were 0.85 or higher for most compounds, indicating that homes would be ranked similarly using both methods. Overall, there appears to be no clear difference in the quality of the pesticide, PAH, or PCB concentration data for the 2 dust collection methods. KW - 2,4-D KW - 2-phenylphenol KW - aromatic hydrocarbons KW - carbamate insecticides KW - carbaryl KW - chlordane KW - chlorpyrifos KW - DDE KW - DDT KW - dwellings KW - fungicides KW - herbicides KW - house dust KW - methoxychlor KW - organochlorine insecticides KW - organophosphorus insecticides KW - pentachlorophenol KW - permethrin KW - pesticide residues KW - polychlorinated biphenyls KW - propoxur KW - pyrethroid insecticides KW - (2,4-dichlorophenoxy)acetic acid KW - chlorpyrifos-ethyl KW - dicophane KW - fungistats KW - p,p'-dichlorodiphenyldichloroethylene KW - PCBs KW - vacuum cleaners KW - weedicides KW - weedkillers KW - Pesticides and Drugs (General) (HH400) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505054&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein GP120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. AU - Liapi, C. AU - Takahashi, N. AU - Raynaud, F. AU - Evain-Brion, D. AU - Anderson, W. B. JO - Journal of Investigative Dermatology JF - Journal of Investigative Dermatology Y1 - 1998/// VL - 110 IS - 4 SP - 332 EP - 337 SN - 0022-202X AD - Liapi, C.: Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bldg. 37, Room 1E14, Bethesda, MD 20892, USA. N1 - Accession Number: 19982007764. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 61-19-8, 60-92-4, 9026-43-1. N2 - Because treatment of patients with peptide T (an octapeptide sequence found in HIV-1 gp120) has been observed to result in an improvement in the psoriatic condition, studies were initiated to determine if peptide T and gp120 protein treatment of normal and psoriatic human fibroblasts resulted in any changes in protein kinase (PKA) activity. The results indicated that peptide T and gp120 protein may inversely alter the intracellular levels of 8-azido-[32P]cAMP binding to the RI and RII regulatory subunits of PKA, and of PKA activity in susceptible cells. These observed changes in the cyclic AMP-PKA signalling pathway, a biochemical marker for psoriasis, may offer some mechanistic insight into the noted beneficial effects of peptide T treatment, including an improvement in psoriatic lesions. KW - acquired immune deficiency syndrome KW - AMP KW - c-AMP KW - envelope protein gp120 KW - fibroblasts KW - glycoproteins KW - human diseases KW - human immunodeficiency viruses KW - peptides KW - protein kinase KW - psoriasis KW - skin KW - skin diseases KW - treatment KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adenosine monophosphate KW - AIDS KW - cyclic adenosine monophosphate KW - cyclic AMP KW - dermatoses KW - dermis KW - gp120 KW - human immunodeficiency virus KW - peptide T KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007764&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic studies in Borrelia burgdorferi. AU - Rosa, P. AU - Bono, J. AU - Elias, A. AU - Errett, J. AU - Kupko, J. AU - Stevenson, B. AU - Taylor, G. AU - Tilly, K. JO - Wiener Klinische Wochenschrift JF - Wiener Klinische Wochenschrift Y1 - 1998/// VL - 110 IS - 24 SP - 859 EP - 862 SN - 0043-5325 AD - Rosa, P.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19990505792. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A previously developed method by which DNA without a naturally occurring B. burgdorferi homologue can be introduced into and stably maintained by B. burgdorferi, was exploited to investigate the utility of additional antibiotic resistance markers in B. burgdorferi. The feasibility of specific gene inactivation by allelic exchange is demonstrated. KW - genes KW - genetic engineering KW - inactivation KW - transformation KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - genetic manipulation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505792&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Growth of infectious and non-infectious B. burgdorferi at different salt concentrations. AU - Elias, A. AU - Bono, J. L. AU - Tilly, K. AU - Rosa, P. JO - Wiener Klinische Wochenschrift JF - Wiener Klinische Wochenschrift Y1 - 1998/// VL - 110 IS - 24 SP - 863 EP - 865 SN - 0043-5325 AD - Elias, A.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903, South Fourth Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19990505793. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 ref. Registry Number: 7647-14-5. Subject Subsets: Medical & Veterinary Entomology N2 - The effect of increased osmotic strength of culture media on growth of infectious and non-infectious Borrelia burgdorferi strains B31 and N40 was investigated. Relatively small increases in the NaCl concentration of the medium significantly inhibited growth in infectious as well as non-infectious strains. Growth of low passage, infectious clone B31-4a was more sensitive to increased NaCl concentrations than high passage, non-infectious clone B31-a. Growth of 2 infectious N40 strains, 1 low passage (N40-Lp) and 1 high passage (N40-P31) was more resistant to increased NaCl concentration than growth of infectious B31-4a. It is concluded that osmotic strength is an important physical parameter for growth of B. burgdorferiin vitro and could influence its ability to adapt and to establish an infection within ticks and mammals. KW - cell culture KW - culture media KW - culture techniques KW - environmental factors KW - growth KW - osmotic pressure KW - sodium chloride KW - strains KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - NaCl KW - osmolality KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505793&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. AU - Perkins, S. N. AU - Hursting, S. D. AU - Phang, J. M. AU - Haines, D. C. JO - Journal of Investigative Dermatology JF - Journal of Investigative Dermatology Y1 - 1998/// VL - 111 IS - 2 SP - 292 EP - 296 SN - 0022-202X AD - Perkins, S. N.: Laboratory of Nutritional and Molecular Regulation, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19981414164. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition N2 - Heterozygous p53-deficient (p53+/-) mice (in which the inactivation of one allele of the p53 tumour suppressor gene increases susceptibility to spontaneous and carcinogen-induced tumour development) and wild-type (WT) litter mates were subjected to a 2-stage skin carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. Instead of skin carcinomas, the chemical treatment protocol caused ulcerous skin lesions and 89% of mice fed ad libitum died from infection/septicaemia. When WT mice were restricted to 60% of the average energy intake of the respective ad libitum group, only 33% developed such lesions and the energy restricted (ER) mice survived twice as long on average as the ad libitum mice. ER also extended life span in p53+/- mice, but 50% of p53+/- mice subjected to ER still developed skin ulcers and the mean life span was shorter than that seen in WT mice. Differences in response to ER between WT and p53+/- mice may be due to the reduction in p53 gene dosage or dissimilarity in the application of the ER treatment. It is concluded that some of the beneficial effects of ER may need full expression of p53 for complete realization. KW - carcinogenesis KW - dermatitis KW - energy KW - energy restricted diets KW - intake KW - lifespan KW - mortality KW - neoplasms KW - restricted feeding KW - skin diseases KW - skin lesions KW - tumours KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - calorie-restricted diets KW - cancers KW - death rate KW - dermatoses KW - tumors KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414164&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - No evidence of human herpesvirus 8 infection in patients with paraneoplastic pemphigus, pemphigus vulgaris, or pemphigus foliaceus. AU - Cohen, S. S. AU - Weinstein, M. D. AU - Herndier, B. G. AU - Anhalt, G. J. AU - Blauvelt, A. JO - Journal of Investigative Dermatology JF - Journal of Investigative Dermatology Y1 - 1998/// VL - 111 IS - 5 SP - 781 EP - 783 SN - 0022-202X AD - Cohen, S. S.: Dermatology Branch, National Cancer Institute, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19982014744. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health N2 - In a search for additional human herpesvirus 8 (HHV-8)-associated diseases, patients attending a hospital in Maryland, USA, with paraneoplastic pemphigus, pemphigus vulgaris and pemphigus foliaceus, were studied [date not given]. Using an immunofluorescence assay able to specifically detect antibodies directed against lytically induced HHV-8 antigens, HHV-8 antibodies were not detected in sera from 24 patients with paraneoplastic pemphigus (including 10 with concomitant Castleman's disease) nor from 19 patients with pemphigus vulgaris. Sera from patients with Kaposi's sarcoma and from healthy US blood donors were positive (25 of 26) and negative (none of 20), respectively. In addition, HHV-8 DNA was not found in frozen lesional skin of 5 patients with pemphigus vulgaris and 5 patients with pemphigus foliaceus by nested PCR (lower limit of detection = 10 copies viral DNA per µg total cellular DNA). Finally, tissue sections of lesional skin from 10 patients with pemphigus vulgaris were negative for HHV-8 by in situ hybridization, using probes able to detect both latently and lytically expressed HHV-8 genes in Kaposi's sarcoma tissue. In summary, no evidence of HHV-8 infection was found in all types of pemphigus using a variety of methods. These findings do not support a general role for HHV-8 in skin diseases associated with immunosuppression. KW - antibodies KW - detection KW - DNA KW - human diseases KW - immunofluorescence KW - Kaposi's sarcoma KW - pemphigus (skin disease) KW - polymerase chain reaction KW - serology KW - skin diseases KW - Maryland KW - USA KW - human herpesvirus 8 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Rhadinovirus KW - Gammaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - deoxyribonucleic acid KW - dermatoses KW - fluorescent antibody technique KW - IFAT KW - PCR KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014744&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium ookinete development in the mosquito midgut: a case of reciprocal manipulation. AU - Shahabuddin, M. A2 - Hurd, H. A2 - Lane, R. A2 - Chappell, L. H. JO - Parasitology JF - Parasitology Y1 - 1998/// VL - 116 SP - S83 EP - S93 SN - 0031-1820 AD - Shahabuddin, M.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B2-37, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19980506666. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 95 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - Plasmodium ookinete development and its interactions with the Anopheles vector are reviewed. Development to ookinete allows the parasite to escape from the tightly packed blood bolus, to cross the peritrophic matrix, to be protected from the digestive environment of the midgut lumen and to invade the gut epithelium. The success of these activities may depend on the ability of the ookinete to overcome biochemical and physical barriers in the mosquito. Ookinete motility, secretion of chitinase, resistance to digestive enzymes, and recognition and invasion of the midgut epithelium may play crucial roles in the transformation to oocyst. Sporogonic development depends on the outcome of these host-parasite interactions. The study of ookinete development and its relationship with the mosquito gut may lead to the design of novel transmission-blocking strategies. KW - development KW - developmental stages KW - disease transmission KW - disease vectors KW - epithelium KW - host parasite relationships KW - interactions KW - life history KW - midgut KW - ookinetes KW - parasites KW - reviews KW - sporogony KW - Anopheles KW - Culicidae KW - Diptera KW - Plasmodium KW - protozoa KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - growth phase KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506666&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Three-dimensional structure of HIV-1 Rev protein filaments. AU - Watts, N. R. AU - Misra, M. AU - Wingfield, P. T. AU - Stahl, S. J. AU - Cheng NaiQian AU - Trus, B. L. AU - Steven, A. C. AU - Williams, R. W. JO - Journal of Structural Biology JF - Journal of Structural Biology Y1 - 1998/// VL - 121 IS - 1 SP - 41 EP - 52 SN - 1047-8477 AD - Watts, N. R.: Bldg 6, Rm B2-34, 6 Center Drive MSC 2727, National Institutes of Health, Bethesda, MD 20892-2717 USA. N1 - Accession Number: 19982008142. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 63231-63-0. N2 - The structure of Rev filaments formed in the absence of RNA was determined. These filaments may be related to the form in which Rev accumulates at the nuclear envelope prior to import. They consist of a 6-start set of helices of molecular dimers, with 31 subunits in 2 turns. Taking into account spectroscopic and other data, a tentative model is proposed, wherein the α-helices in the amino-terminal domain of Rev are in approximate alignment with each other and with the filament axis and are probably located on the inner surface of the filament wall. The carboxy-terminal domain, putatively composed in part of antiparallel beta sheet, may form the smooth outer surface. KW - biochemistry KW - human diseases KW - Rev protein KW - RNA KW - structure KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008142&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - From research to global reality: the micronutrient story. AU - Underwood, B. A. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1998/// VL - 128 IS - 2 SP - 145 EP - 151 SN - 0022-3166 AD - Underwood, B. A.: National Eye Institute, National Institute of Health, Bethesda, MD 20814, USA. N1 - Accession Number: 19991413464. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition N2 - A biographical report of the contribution of E. V. McCollum to micronutrient research is presented. KW - history KW - nutrition research KW - nutritionists KW - trace elements KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - microelements KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413464&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - α-Tocopherol concentrations in plasma but not in lipoproteins fluctuate during the menstrual cycle in healthy premenopausal women. AU - Lanza, E. AU - Forman, M. R. AU - Johnson, E. J. AU - Muesing, R. A. AU - Graubard, B. I. AU - Beecher, G. R. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1998/// VL - 128 IS - 7 SP - 1150 EP - 1155 SN - 0022-3166 AD - Lanza, E.: Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 20001409284. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 59-02-9, 57-88-5, 1406-18-4. Subject Subsets: Human Nutrition N2 - 12 free-living women, with a confirmed ovulatory cycle, were given a controlled diet for 2 consecutive menstrual cycles. Blood was drawn during the menses, early follicular, late follicular and luteal phases to simultaneously measure serum hormones, plasma lipoproteins and α-tocopherol (A-T) concentrations, and A-T distribution in the lipoprotein fractions. Plasma A-T concentrations were lower during menses than during the luteal phase by ~12% in each controlled diet cycle (P<0.001). Adjustment for serum cholesterol and triglyceride concentrations did not alter these findings. The distributions of A-T in lipoprotein cholesterol fractions were not significantly different by menstrual phase. From 61 to 62% of A-T was concentrated in the LDL fraction, with another 9-14% in HDL2, 17-22% in HDL3 and the remaining 6-8% in VLDL plus IDL. There were no significant differences in lipoprotein cholesterol fractions by menstrual phase, except for a increase (P=0.03) in HDL2 cholesterol from the early follicular to the late follicular phase. Spearman rank correlations from data during the second controlled diet month showed A-T in HDL2 in the late follicular phase was positively correlated with HDL cholesterol in the early follicular (r=0.88), late follicular (r=0.86) and luteal phases (r=0.86) and with luteal apolipoprotein (apo a-1) level (r=0.90), and luteal HDL2 cholesterol (r=0.83). A-T in HDL3 in the early follicular phase was negatively correlated with HDL2 cholesterol (r=-0.96) and apo a-1 (r=-0.85), whereas luteal A-T in HDL3 was correlated with luteal HDL3 cholesterol (r=-0.79). Late follicular A-T in VLDL was positively correlated with early follicular HDL3 cholesterol and late follicular HDL3 cholesterol (r=0.83). Fluctuations of A-T concentrations by phase of the menstrual cycle should be taken into consideration in future research concerning premenopausal women and the risk of chronic disease. KW - alpha-tocopherol KW - antioxidants KW - carotenoids KW - cholesterol KW - hormones KW - lipoproteins KW - menstrual cycle KW - vitamin E KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - tetraterpenoids KW - Human Reproduction and Development (VV060) KW - Physiology of Human Nutrition (VV120) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001409284&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children. AU - Grenade, L. la AU - Manns, A. AU - Fletcher, V. AU - Carberry, C. AU - Hanchard, B. AU - Maloney, E. M. AU - Cranston, B. AU - Williams, N. P. AU - Wilks, R. AU - Kang, E. C. AU - Blattner, W. A. JO - Archives of Dermatology JF - Archives of Dermatology Y1 - 1998/// VL - 134 IS - 4 SP - 439 EP - 444 SN - 0003-987X AD - Grenade, L. la: Department of Medicine, University of the West Indies, Kingston, Jamaica. Correspondence address [Manns, A.]: Viral Epidemiology Branch, National Cancer Institute, 6130 Executive Blvd, Suite 434, Rockville, MD 20892, USA. N1 - Accession Number: 19982007618. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4. N2 - At 2 hospitals in Kingston, Jamaica, consecutive patients older than 1.5 years diagnosed as having infective dermatitis (ID; n=50) and atopic dermatitis (AD; n=35) were enrolled based on clinical findings. The mean ages of patients with ID and AD were 6.9 and 7.8 years, respectively. Histologically, both diseases were predominantly chronic dermatitis with propensity for skin colonization with Staphylococcus aureus and β-haemolytic streptococci; however, the distribution of sites of skin involvement differed. Infection with HTLV-I was the most distinguishing feature among patients with ID, with seropositive results in 100%; only 5 (14%) of the 35 patients with AD had results seropositive for HTLV-I. Infective dermatitis was further characterized by dermatopathic lymphadenitis in 16 (67%) of 24 patients with palpable nodes. Anaemia, lymphocytosis, and low albumin and elevated serum globulin levels were more prevalent among patients with ID. Significant elevations of IgA, IgD, and IgG levels were observed among patients with ID compared with those with AD. However, both patients with AD and those with ID had levels of IgD and IgE elevated above the normal range. T-cell subsets among patients with ID revealed T-cell activation with a high percentage of HLA-DR antigen positivity, elevated CD4+ (2.4 × 109/L) and CD8+ (1.4 × 109/L) cell counts, with an increased CD4/CD8 ratio of 1:73. KW - albumins KW - antigens KW - atopy KW - CD4 antigens KW - CD8 antigens KW - children KW - chronic course KW - dermatitis KW - diagnosis KW - differential diagnosis KW - human diseases KW - IgA KW - IgE KW - IgG KW - immunoglobulins KW - laboratories KW - leukocyte count KW - lymphadenitis KW - lymphocyte transformation KW - T lymphocytes KW - Caribbean KW - Jamaica KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Staphylococcus KW - Staphylococcus aureus KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Staphylococcaceae KW - Bacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Staphylococcus KW - America KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - antigenicity KW - bacterium KW - CD4 KW - CD8 KW - cell count KW - gamma-globulins KW - HTLV-BLV group KW - IgD KW - immune globulins KW - immunogens KW - reagin KW - reaginic antibodies KW - T cells KW - West Indies KW - Health Services (UU350) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007618&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV. AU - Meng, X. J. AU - Halbur, P. G. AU - Haynes, J. S. AU - Tsareva, T. S. AU - Bruna, J. D. AU - Royer, R. L. AU - Purcell, R. H. AU - Emerson, S. U. JO - Archives of Virology JF - Archives of Virology Y1 - 1998/// VL - 143 IS - 7 SP - 1405 EP - 1415 SN - 0304-8608 AD - Meng, X. J.: Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982214236. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science N2 - Specific-pathogen-free pigs were inoculated i.v. with swine HEV (4 pigs) or with about 105 monkey infectious doses of 1 of 2 human strains (Sar-55 or Mex-14) of HEV (6 pigs). Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs inoculated with serum samples containing swine HEV seroconverted to anti-HEV 4 to 8 weeks after inoculation, and the virus spread to an uninoculated pig housed in the same room. Swine HEV was detected in nasal and rectal swab materials as early as 2 weeks after inoculation and for 4 to 8 weeks thereafter. Viraemia appeared 4 to 6 weeks after inoculation and lasted 1 to 3 weeks. The inoculated pigs appeared clinically normal and serum liver enzymes were not significantly elevated. In contrast, pigs were not infected when inoculated with the human strains of HEV. KW - experimental infection KW - pathology KW - strains KW - viraemia KW - hepatitis E virus KW - man KW - pigs KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Sus scrofa KW - Sus KW - Suidae KW - Suiformes KW - Artiodactyla KW - experimental transmission KW - hogs KW - swine KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982214236&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. AU - Bono, J. L. AU - Tilly, K. AU - Stevenson, B. AU - Hogan, D. AU - Rosa, P. JO - Microbiology (Reading) JF - Microbiology (Reading) Y1 - 1998/// VL - 144 IS - 4 SP - 1033 EP - 1044 SN - 1350-0872 AD - Bono, J. L.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19980504818. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Medical & Veterinary Entomology N2 - To elucidate the importance of oligopeptide permease for B. burgdorferi, a chromosomal locus in B. burgdorferi that encodes homologues of all 5 subunits of oligopeptide permease was identified and characterized. B. burgdorferi has multiple copies of the gene encoding the peptide-binding component, OppA; 3 reside at the chromosomal locus and 2 are on plasmids. Northern analyses indicate that each oppA gene is independently transcribed, although the 3 chromosomal oppA genes are also expressed as bi- and tri-cistronic messages. Induction of one of the plasmid-encoded oppA genes was observed following an increase in temperature, which appears to be an important cue for adaptive responses in vivo. The deduced amino acid sequences suggest that all 5 borrelial OppA homologues are lipoproteins, but the protease-resistance of at least one of them in intact bacteria is inconsistent with outer-surface localization. Insertional inactivation of a plasmid-encoded oppA gene demonstrates that it is not essential for growth in culture. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are AF000365 (oppAV), AF000366 (chromosomal opp locus) and AF000948 (oppAIV). KW - amino acid sequences KW - chromosomes KW - genes KW - lipoproteins KW - molecular genetics KW - nucleotide sequences KW - plasmids KW - temperature KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - DNA sequences KW - oligopeptide permease KW - permease KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504818&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi. AU - Stevenson, B. AU - Casjens, S. AU - Rosa, P. JO - Microbiology (Reading) JF - Microbiology (Reading) Y1 - 1998/// VL - 144 IS - 7 SP - 1869 EP - 1879 SN - 1350-0872 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA. N1 - Accession Number: 19990500684. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - A single B. burgdorferi bacterium may contain 6 or more different 32 kb circular plasmids (cp32s). Although these plasmids are homologous throughout much of their sequences, 2 loci were identified at which they can vary significantly. The cp32 plasmids and their relatives each contain 2 adjacent genes, orfC and orf3, that vary in sequence between plasmids found within clones of individual bacteria. The orfC gene product is homologous to proteins involved in partitioning of bacterial plasmids, and the differences at this locus between plasmids may account for their compatibility. The orfC-orf3 loci are located ~5 kb from another variable locus called erp. The orfC-orf3 loci were used as physically linked markers to assess genetic rearrangements in the erp loci; this revealed examples of recombination involving both individual genes and entire erp loci. Recombination of the genes encoding the Erp antigens might contribute to the evasion of the mammalian immune response and could play roles in the establishment and persistence of B. burgdorferi infections in mammalian hosts. The EMBL/GenBank/DDBJ accession numbers for the orfC-orf3 loci of B31 plasmids, cp32-2, cp32-3, cp32-4, cp32-6 and cp32-7 are AF022479-AF022483, respectively. KW - antigens KW - biotechnology KW - genes KW - immunity KW - loci KW - molecular genetics KW - nucleotide sequences KW - plasmids KW - proteins KW - recombination KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - biochemical genetics KW - DNA sequences KW - genetic recombination KW - immunogens KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500684&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Use of neural networks to model complex immunogenetic associations of disease: human leukocyte antigen impact on the progression of human immunodeficiency virus infection. AU - Ioannidis, J. P. A. AU - McQueen, P. G. AU - Goedert, J. J. AU - Kaslow, R. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1998/// VL - 147 IS - 5 SP - 464 EP - 471 SN - 0002-9262 AD - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Solar Bldg, Rm 2C31, 6003 Executive Blvd., Bethesda, MD 20892, USA. N1 - Accession Number: 19982005297. Publication Type: Journal Article. Language: English. Number of References: 30 ref. N2 - Neural networks offer further support to the notion that HIV disease progression may be dependent on complex interactions between different class I and class II alleles and transporters associated with antigen-processing variants. The effect of the current models is of moderate magnitude, and more data as well as other host and pathogen variables may need to be considered to improve the performance of the models. Artificial intelligence methods may complement linear statistical methods for evaluating immunogenetic associations of disease. KW - computers KW - disease course KW - human diseases KW - human immunodeficiency viruses KW - immunogenetics KW - interactions KW - major histocompatibility complex KW - statistical analysis KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - histocompatibility complex KW - human immunodeficiency virus KW - human leukocyte antigen KW - statistical methods KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005297&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Direct and indirect estimates of HIV-1 incidence in a high-prevalence population. AU - Cleghorn, F. R. AU - Jack, N. AU - Murphy, J. R. AU - Edwards, J. AU - Mahabir, B. AU - Paul, R. AU - O'Brien, T. AU - Greenberg, M. AU - Weinhold, K. AU - Bartholomew, C. AU - Brookmeyer, R. AU - Blattner, W. A. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1998/// VL - 147 IS - 9 SP - 834 EP - 839 SN - 0002-9262 AD - Cleghorn, F. R.: Viral Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982013035. Publication Type: Journal Article. Language: English. Number of References: 21 ref. N2 - The authors set out to estimate HIV-1 incidence in a population of heterosexual sexually transmitted disease clinic attendees in Trinidad who had a known high prevalence of HIV-1 subtype B. During 1987-1995, HIV-1 incidence estimates from serial cross-sectional studies of HIV-1 prevalence, passive follow-up of clinic recidivists, modeling of early markers of HIV-1 infection (p24 antigen screening), and a cohort study of seronegative genital ulcer disease cases were compared. Measuring incidence density in the genital ulcer disease cases directly gave the highest estimate, 6.9% per annum. Screening for the detection of early HIV-1 markers yielded an incidence of 5.0% per annum, while estimating incidence from serial cross-sectional prevalence data and clinic recidivists gave estimates of 3.5% and 4.5% per annum, respectively. These results were found to be internally consistent. Indirect estimates of incidence based on prevalence data can give accurate surrogates of true incidence. Within limitations, even crude measures of incidence are robust enough for health planning and evaluation purposes. For planning vaccine efficacy trials, consistent conservative estimates may be used to evaluate populations before targeting them for cohort studies. KW - epidemiology KW - estimates KW - human diseases KW - incidence KW - sexually transmitted diseases KW - Trinidad and Tobago KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Lesser Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - estimations KW - human immunodeficiency virus type 1 KW - sexually transmitted infections KW - STDs KW - Trinidad & Tobago KW - venereal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013035&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relation of self-image to body size and weight loss attempts in black women: the CARDIA study. AU - Riley, N. M. AU - Bild, D. E. AU - Cooper, L. AU - Schreiner, P. AU - Smith, D. E. AU - Sorlie, P. AU - Thompson, J. K. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1998/// VL - 148 IS - 11 SP - 1062 EP - 1068 SN - 0002-9262 AD - Riley, N. M.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. N1 - Accession Number: 19991402916. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition N2 - It has been suggested that the prevalence of obesity in black women is high partly because self-image in black women is not strongly dependent on body size. To determine associations between self-image, body size, and dieting behavior among black women, the authors assessed an Appearance Evaluation Subscale (AES) score (range, 1-5), a Body Image Satisfaction (BIS) score (range, 2-11), and reported dieting behaviour in a population-based sample of 1143 black women aged 24-42 years from the fourth follow-up examination (1992-93) of the Coronary Artery Risk Development in Young Adults (CARDIA) Study conducted in the USA. After adjustment for age, education, smoking, and physical activity, women in the lowest, middle, and highest tertiles of body mass index (weight (kg)/height (m)²) had mean AES scores of 3.7, 3.3, and 2.9, respectively (P<0.001), and mean BIS scores of 7.8, 6.7, and 5.9, respectively (P<0.001). After additional control for body mass index as a continuous variable, both AES and BIS scores were inversely related to ever dieting, current dieting, and previous weight loss of 10 pounds (4.5 kg) or more in all tertiles of body mass index. These results suggest that among black women, a higher body mass index is associated with poorer self-image and lower body size satisfaction and that these perceptions may be an avenue to promoting weight control. KW - behaviour KW - blacks KW - body image KW - body weight KW - ethnic groups KW - obesity KW - weight reduction KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - behavior KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402916&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mechanisms of symptom in Bartoszyn´ski's virus model. AU - Kim, Y. JO - Mathematical Biosciences JF - Mathematical Biosciences Y1 - 1998/// VL - 153 IS - 1 SP - 63 EP - 78 CY - New York; USA PB - Elsevier Science Inc. SN - 0025-5564 AD - Kim, Y.: National Institutes of Health, 6100 Executive Blvd. 7B13, Rockville, MD 20852, USA. N1 - Accession Number: 20013181409. Publication Type: Journal Article. Language: English. Number of References: 12 ref. N2 - R. Bartoszyn´ski presented a model describing the growth of rabies virus in a human host after infection by a rabid animal. This paper is concerned with that model. Our main interests are in developing mechanisms of a symptom - how the probability of the occurrence of the symptom is related to the process. Four mechanisms are suggested based on various biological backgrounds. The main variable of interests is the survival time - the time elapsing between initial infection and the occurrence of the symptom. Analytical results about the survival functions induced from the four suggested mechanisms are studied. KW - clinical aspects KW - disease course KW - human diseases KW - infection KW - mathematical models KW - pathogenesis KW - rabies KW - symptoms KW - man KW - rabies virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lyssavirus KW - Rhabdoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - clinical picture KW - disease progression KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Mathematics and Statistics (ZZ100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013181409&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Unconventional therapies for cancer. 5. Vitamins A, C and E. AU - Kaegi, E. JO - Canadian Medical Association Journal JF - Canadian Medical Association Journal Y1 - 1998/// VL - 158 IS - 11 SP - 1483 EP - 1488 SN - 0820-3946 AD - Kaegi, E.: National Cancer Institute, Canada. N1 - Accession Number: 19981418495. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Registry Number: 50-81-7, 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition KW - antioxidants KW - ascorbic acid KW - diet treatment KW - neoplasms KW - retinol KW - treatment KW - vitamin E KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - cancers KW - diet prescription KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981418495&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cutting edge: HIV-1 infection induces a selective reduction in STAT5 protein expression. AU - Pericle, F. AU - Pinto, L. A. AU - Hicks, S. AU - Kirken, R. A. AU - Sconocchia, G. AU - Rusnak, J. AU - Dolan, M. J. AU - Shearer, G. M. AU - Segal, D. M. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 160 IS - 1 SP - 28 EP - 31 SN - 0022-1767 AD - Pericle, F.: Bldg 10, Rm 4B17, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982001924. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - HIV-1 infection is accompanied by qualitative and quantitative defects in CD4+ T lymphocytes. Loss of immune function in HIV patients is usually associated with a profound dysregulation of cytokine production. To investigate whether cytokine signalling defects occur during HIV infection, PHA blasts from healthy human donors were infected with two strains of HIV-1 and screened for the expression of signal transducer and activator of transcription (STAT) proteins used in cytokine signalling. A selective decrease in STAT5B was seen 8 days after infection with the BZ167 dual-tropic HIV isolate, but not with the Ba-L, M-tropic strain. Based on these findings, purified T cells from HIV-infected patients in different stages of disease were also tested for STAT expression; decreases in STAT5A, STAT5B, and STAT1α were observed in all patients. The reduction in STATs seen in vivo and in vitro after HIV infection may contribute to the loss of T cell function in HIV disease. KW - cytokines KW - donors KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunopathology KW - in vitro KW - infection KW - pathogenesis KW - patients KW - proteins KW - strains KW - T lymphocytes KW - transcription KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA transcription KW - functions KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001924&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Helminth antigens selectively differentiate unsensitized CD45RA+CD4+ human T cells in vitro. AU - Steel, C. AU - Nutman, T. B. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 160 IS - 1 SP - 351 EP - 360 SN - 0022-1767 AD - Steel, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980804966. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Registry Number: 9008-11-1, 207137-56-2. Subject Subsets: Helminthology N2 - To examine the relationship between early exposure to filarial antigen and subsequent immune responsiveness, CD45RA+CD4+ cells from normal unsensitized donors were stimulated in vitro with soluble microfilarial antigen (MfAg) from Brugia malayi in the presence of antigen presenting cells. MfAg alone induced proliferation and IFN-γ and IL-5 production in unsensitized CD45RA+CD4+ cells, demonstrating the ability of filarial antigens to prime naive T cells in the absence of exogenous cytokines and dendritic cells. Adding exogenous cytokine(s) (particularly IL-12 and IL-4) during priming altered the MfAg-specific responses of CD45RA+CD4+ cells as well as subsequent responses to antigen. Priming solely with MfAg led to enhanced IL-5 production following antigen restimulation, suggesting that MfAg preferentially primes for type 2 responses. KW - antigens KW - cytokines KW - helminths KW - immune response KW - in vitro KW - interferon KW - interleukin 12 KW - interleukin 4 KW - interleukin 5 KW - microfilariae KW - parasites KW - T lymphocytes KW - Brugia malayi KW - Brugia KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - antigenicity KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804966&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infection of mice lacking the common cytokine receptor γ-chain (γc) reveals an unexpected role for CD4+ T lymphocytes in early IFN-γ-dependent resistance to Toxoplasma gondii. AU - Scharton-Kersten, T. AU - Nakajima, H. AU - Yap, G. AU - Sher, A. AU - Leonard, W. J. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 160 IS - 6 SP - 2565 EP - 2569 SN - 0022-1767 AD - Scharton-Kersten, T.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980804759. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - Mice lacking the common cytokine receptor γ-chain (γc) gene exhibit defective development of natural killer (NK) cells and CD8+ T cells and greatly diminished production of interferon (IFN)-γ. Because resistance of SCID mice to Toxoplasma gondii requires interleukin (IL)-12-dependent IFN-γ production by NK cells, it was expected that γc-deficient mice would succumb rapidly to the parasite. However, most γc-deficient mice survived the acute phase of T. gondii infection. As in wild-type mice, this resistance required IL-12 and IFN-γ but whereas wild-type mice depleted of CD4+ T cells survived, anti-CD4+ treated γc-deficient mice displayed diminished production of IFN-γ and all succumbed to acute infection. The results indicate a role for CD4+ T lymphocytes in IFN-γ-dependent host defence and also establish SCID and γc-deficient mice as powerful complementary tools for assessing the function of NK versus CD4+ T cells in immunopathophysiological responses. KW - cytokines KW - disease resistance KW - experimental infections KW - immune response KW - interferon KW - interleukin 12 KW - laboratory animals KW - mutants KW - natural killer cells KW - parasites KW - receptors KW - T lymphocytes KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - resistance to disease KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804759&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. AU - Rubbert, A. AU - Combadiere, C. AU - Ostrowski, M. AU - Arthos, J. AU - Dybul, M. AU - Machado, E. AU - Cohn, M. A. AU - Hoxie, J. A. AU - Murphy, P. M. AU - Fauci, A. S. AU - Weissman, D. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 160 IS - 8 SP - 3933 EP - 3941 SN - 0022-1767 AD - Rubbert, A.: Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, Bldg 10, Rm 6A02, 10 Center Drive, MSC-1576, Bethesda, MD 20892-1570, USA. N1 - Accession Number: 19982006881. Publication Type: Journal Article. Language: English. Number of References: 65 ref. N2 - Cells of the dendritic lineage are thought to be among the first cells infected after mucosal exposure to HIV. This study revealed the presence of multiple chemokine receptors on dendritic cells (DCs) that may function as coreceptors for HIV entry. DC effectively used CCR5 for entry of macrophage (M)-tropic isolates. CCR3, the eotaxin receptor, initially identified on eosinophils, is expressed on DCs and may be used as an entry coreceptor by certain dual-tropic strains. CXCR4 was not expressed on DCs, although SDF-1 induced a calcium flux and DCs could be infected by T-cell line (T)-tropic HIV. These findings provide evidence for the presence of a non-CXCR4 SDF-1 receptor on DCs that is used mainly by T-tropic strains of HIV. DCs from individuals homozygous for a 32-bp deletion of the CCR5 gene are also infectable with M-tropic strains of HIV-1, and this infection is inhibited by stromal cell-derived factor (SDF)1, suggesting that this receptor can also be used by M-tropic HIV for entry. Delineation of the spectrum of coreceptor usage on DCs may offer new approaches to interfere with the initiation and propagation of HIV infections. KW - cell lines KW - chemokines KW - cytokines KW - dendritic cells KW - eosinophils KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - infections KW - macrophages KW - mucosa KW - receptors KW - replication KW - sexual transmission KW - strains KW - T lymphocytes KW - transmission KW - tropisms KW - uptake KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - eosinophil leukocytes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mucous membrane KW - T cells KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006881&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-10 regulates liver pathology in acute murine schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. AU - Wynn, T. A. AU - Cheever, A. W. AU - Williams, M. E. AU - Hieny, S. AU - Caspar, P. AU - Kühn, R. AU - Müller, W. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 160 IS - 9 SP - 4473 EP - 4480 SN - 0022-1767 AD - Wynn, T. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980805592. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 308079-78-9. Subject Subsets: Helminthology N2 - IL-10 gene knockout mice (IL-10T) were used to examine the role of endogenous IL-10 in the down-modulation of hepatic granuloma formation and lymphocyte responses that occurs in chronic infection with Schistosoma mansoni. Although IL-10-deficient animals showed 20 to 30% mortality between 8 and 14 weeks pi, they displayed no alterations in their susceptibility to infection and produced similar numbers of eggs as their wild-type littermates. The IL-10T mice displayed a significant increase in hepatic granuloma size at the acute stage of infection, which was associated with increased IFN-γ, IL-2, IL-1β, and TNF-α mRNA expression in liver and elevated Th1-type cytokine production by lymphoid cells. Despite developing an enhanced Th1-type cytokine response, the IL-10T mice showed no consistent decrease in their Th2-type cytokine profile. Although granulomatous inflammation was enhanced at the acute stage of infection, the livers of IL-10T mice displayed no significant increase in fibrosis and underwent normal immune down-modulation at the chronic stage of infection. Moreover, the down-modulated state could be induced in IL-10T mice by sensitizing the animals to schistosome eggs before infection, further demonstrating that the major down-regulatory mechanism is not dependent upon IL-10. It is concluded that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection. KW - acute course KW - chronic course KW - cytokines KW - experimental infections KW - granuloma KW - helminths KW - immune response KW - immunopathology KW - inflammation KW - interferon KW - interleukin 1 KW - interleukin 10 KW - interleukin 2 KW - laboratory animals KW - liver KW - lymphocytes KW - mortality KW - parasites KW - pathology KW - susceptibility KW - Th1 lymphocytes KW - Th2 lymphocytes KW - tumour necrosis factor KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - cachectin KW - cachexin KW - death rate KW - gene knockout mice KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - severe course KW - Strigeida KW - T helper cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805592&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Demonstration of human T lymphotropic virus type I (HTLV-I) Tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection. AU - Kubota, R. AU - Kawanishi, T. AU - Matsubara, H. AU - Manns, A. AU - Jacobson, S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 161 IS - 1 SP - 482 EP - 488 SN - 0022-1767 AD - Kubota, R.: NINDS, National Institutes of Health, Bldg 10, Rm 5B-16, Bethesda, MD 20892, USA. N1 - Accession Number: 19982010481. Publication Type: Journal Article. Language: English. Number of References: 39 ref. N2 - These data suggest that high levels of circulating HTLV-I-specific CD8+ T lymphocytes have the potential to produce proinflammatory cytokines and may promote inflammatory responses to HTLV-I in HAM/TSP patients. KW - CD8+ lymphocytes KW - cytokines KW - human diseases KW - myelopathy KW - pathogenesis KW - Tax protein KW - tropical spastic paraparesis KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - CD8+ cells KW - HTLV-BLV group KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010481&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. AU - Ostrowski, M. A. AU - Justement, S. J. AU - Catanzaro, A. AU - Hallahan, C. A. AU - Ehler, L. A. AU - Mizell, S. B. AU - Kumar, P. N. AU - Mican, J. A. AU - Chun TaiWook AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 161 IS - 6 SP - 3195 EP - 3201 SN - 0022-1767 AD - Ostrowski, M. A.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bldg 10, Rm. 6A11, 10 Center Dr., MSC-1576, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19982013724. Publication Type: Journal Article. Language: English. Number of References: 35 ref. N2 - A cross-sectional study was conducted to evaluate the expression of 2 HIV-1 coreceptors, CCR5 and CXCR4, in whole blood samples taken from HIV-1 infected and uninfected individuals. It is demonstrated that CXCR4 on CD4+ and CD8+ T cells, and CD14+ monocytes is significantly down-regulated, and CCR5 expression on CD4+ T cells is up-regulated in HIV-infected individuals compared with uninfected controls. Coreceptor expression correlated with the level of cellular activation in vivo in both HIV-infected and uninfected individuals, with CXCR4 being expressed predominantly on quiescent (HLA-DR-) T cells and CCR5 being expressed predominantly on activated (HLA-DR+) T cells. Lower expression of CXCR4 and higher expression of CCR5 on CD4+ T cells correlated with advancing disease. In addition, a tendency for greater activation of CXCR4+CD4+ T cells in patients with advanced disease was observed. Patients who harboured syncytium-inducing viruses, however, could not be distinguished from those who harboured nonsyncytium-inducing viruses based on the level of CD4+ T-cell activation or chemokine receptor expression. KW - chemokines KW - cytokines KW - human diseases KW - human immunodeficiency viruses KW - lymphocyte transformation KW - monocytes KW - receptors KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013724&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IFN-γ, IL-12, and TNF-α are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12. AU - Hoffmann, K. F. AU - Caspar, P. AU - Cheever, A. W. AU - Wynn, T. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 161 IS - 8 SP - 4201 EP - 4210 SN - 0022-1767 AD - Hoffmann, K. F.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990803548. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Helminthology N2 - This study of the immunopathology of schistosomiasis showed that mice sensitized with Schistosoma mansoni egg antigens and IL (interleukin)-12, but depleted of IFN (interferon)-γ, IL-12, or TNF (tumour necrosis factor)-α at the time of egg laying, developed granulomas that were similar to the non-IL-12-treated control group. This contrasts with previous findings that similarly sensitized mice not depleted of these cytokines showed marked decreases in pathology compared with controls. Although all 3 anti-cytokine-treated groups exhibited a dominant type 1 response in lymph node cells restimulated ex vivo, the expression of type 2 cytokine mRNA was markedly restored at the site of granuloma formation, which suggests that all 3 cytokines are required to maintain the suppressed type 2 pattern. Moreover, egg/IL-12-sensitized mice depleted of IFN-γ or IL-12 displayed a partial reduction in IFN-γ production, suggesting that multiple type 1 cytokines were required to maintain polarized type 1 responses to chronic type 2-inducing stimuli. Together, these data reveal key roles for IFN-γ, IL-12, and TNF-α in the prevention of immunopathology following immunization with egg antigen and IL-12. KW - animal diseases KW - antigens KW - cytokines KW - experimental infection KW - fibrosis KW - granuloma KW - helminth ova KW - helminths KW - hepatic fibrosis KW - human diseases KW - immune response KW - immunization KW - immunopathology KW - interferon KW - interleukin 12 KW - laboratory animals KW - liver KW - lymph nodes KW - parasites KW - pathology KW - schistosomiasis KW - tumour necrosis factor KW - vaccine development KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - antigenicity KW - bilharzia KW - bilharziasis KW - cachectin KW - cachexin KW - experimental transmission KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803548&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. AU - Wang JiMing AU - Ueda, H. AU - Howard, O. M. Z. AU - Grimm, M. C. AU - Chertov, O. AU - Gong XiaoQi AU - Gong WangHua AU - Resau, J. H. AU - Broder, C. C. AU - Evans, G. AU - Arthur, L. O. AU - Ruscetti, F. W. AU - Oppenheim, J. J. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1998/// VL - 161 IS - 8 SP - 4309 EP - 4317 SN - 0022-1767 AD - Wang JiMing: Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Rm 31-19, Frederick, MD 21702-1201, USA. N1 - Accession Number: 19982014285. Publication Type: Journal Article. Language: English. Number of References: 45 ref. N2 - This study shows that preincubation with gp120 from various strains of HIV-1 can suppress monocyte responses to a variety of chemokines as well as the bacterial peptide FMLP in association with CD4 signal-dependent down-regulation of chemokine receptors. KW - CD4 antigens KW - chemokines KW - cytokines KW - envelope protein gp120 KW - human diseases KW - immune response KW - immunopathology KW - inflammation KW - monocytes KW - pathogenesis KW - receptors KW - Human immunodeficiency virus 1 KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CD4 KW - gp120 KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014285&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recombinant cDNA clones for immunodiagnosis of strongyloidiasis. AU - Ramachandran, S. AU - Thompson, R. W. AU - Gam, A. A. AU - Neva, F. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 1 SP - 196 EP - 203 SN - 0022-1899 AD - Ramachandran, S.: Laboratory of Parasitic Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19980804381. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 37341-29-0, 308067-58-5. Subject Subsets: Helminthology N2 - In order to make diagnosis of Strongyloides easier and more reliable, several recombinant clones from a cDNA library prepared from the infective stage of S. stercoralis, and screened with serum from strongyloidiasis patients, were characterized by sequencing the genes and expressing the proteins in Escherichia coli. Sequence analysis showed these antigens to be rich in proline and charged amino acids. Database searches revealed sequences which were similar but none which were homologous, suggesting that the antigens are unique. The results of ELISA testing indicated that recombinant proteins 5a and 12a were equally as reactive as the larval somatic antigen, if not more so. No cross-reactivity with recombinant antigen 5a was found using sera from patients with filarial or intestinal nematode infections, even though larval somatic antigen did cross-react with some of these. There was only one case of cross-reactivity with antigen 12a. Recombinant antigens 5a and 12a both detected parasite-specific IgE and IgG4 antibodies in Strongyloides-infected patients. It is concluded that these recombinant antigens should be useful in diagnostic and epidemiological studies of strongyloidiasis. KW - antibodies KW - antigens KW - diagnosis KW - DNA libraries KW - ELISA KW - helminths KW - human diseases KW - IgE KW - IgG KW - immunodiagnosis KW - nucleotide sequences KW - parasites KW - recombinant antigens KW - recombinant DNA KW - recombinant proteins KW - strongyloidiasis KW - man KW - Rhabditida KW - Strongyloides stercoralis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - antigenicity KW - DNA sequences KW - enzyme linked immunosorbent assay KW - immunogens KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - serological diagnosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804381&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Investigational vaccine for Escherichia coli O157: phase 1 study of O157 O-specific polysaccharide-Pseudomonas aeruginosa recombinant exoprotein A conjugates in adults. AU - Konadu, E. Y. AU - Parke, J. C., Jr. AU - Tran, H. T. AU - Bryla, D. A. AU - Robbins, J. B. AU - Szu, S. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 2 SP - 383 EP - 387 SN - 0022-1899 AD - Konadu, E. Y.: National Institutes of Health, Bldg. 6, Room 424, Bethesda, MD 20892-2720, USA. N1 - Accession Number: 19982008886. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health N2 - In a phase 1 clinical study, 3 investigational E. coli O157 vaccines were studied in 87 healthy adults from North Carolina, USA [date not given]. The vaccines were prepared by covalently binding E. coli O157 O-specific polysaccharide with P. aeruginosa recombinant exoprotein A. No significant adverse reactions were reported. Most volunteers (81%) responded with a >4-fold increase in IgG lipopolysaccharide (LPS) antibodies 1 week after vaccination; all volunteers responded with a >4-fold rise at 4 weeks and this level was sustained for 26 weeks after injection. All 3 vaccines elicited high titres of serum bactericidal activity that roughly correlated with the serum IgG and IgM LPS antibody levels. A phase 2 study in young children is planned. KW - adults KW - antibodies KW - bacterial diseases KW - clinical trials KW - conjugate vaccines KW - efficacy KW - human diseases KW - IgG KW - IgM KW - immune response KW - immunization KW - lipopolysaccharides KW - vaccination KW - vaccines KW - North Carolina KW - USA KW - Escherichia coli KW - man KW - Pseudomonas aeruginosa KW - Escherichia KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pseudomonas KW - Pseudomonadaceae KW - Pseudomonadales KW - Appalachian States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - South Atlantic States of USA KW - bacterial infections KW - bacterioses KW - bacterium KW - E. coli KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - United States of America KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008886&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection. AU - Lin, F. Y. C. AU - Clemens, J. D. AU - Azimi, P. H. AU - Regan, J. A. AU - Weisman, L. E. AU - Philips, J. B., III AU - Rhoads, G. G. AU - Clark, P. AU - Brenner, R. A. AU - Ferrieri, P. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 3 SP - 790 EP - 792 SN - 0022-1899 AD - Lin, F. Y. C.: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19982007465. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health N2 - The distribution of serotypes of group B streptococci (GBS) isolated from 67 infants with early-onset sepsis are described. Case-infants were assembled from 13 hospitals across the USA from 15 July 1995 to 5 February 1997 through prospective active surveillance. The distribution of GBS serotypes was Ia, 40%; Ib, 9%; II, 6%; III, 27%; V, 15%; and nontypeable, 3%. Type V occurred more frequently in the northeast region (New York and New Jersey) than in other regions (29% vs. 9%, P=0.06). Conversely, type III occurred significantly less frequently in the northeast region than other regions (10% vs. 35%, P=0.04). GBS types Ia, III, and V accounted for 82% of the isolates. It is concluded that this report supports previous observations about the emergence of GBS type V, but it is suggested that conclusions about serotype distributions based on one geographical location or on a small number of patients may not be generally applicable. Continued monitoring seems necessary for the design of a GBS vaccine. KW - bacterial diseases KW - epidemiology KW - group B streptococci KW - human diseases KW - neonates KW - polysaccharides KW - serotypes KW - USA KW - man KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterial infections KW - bacterioses KW - bacterium KW - complex carbohydrates KW - newborn infants KW - United States of America KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007465&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Splenic cytokine responses in Indian kala-azar before and after treatment. AU - Kenney, R. T. AU - Sacks, D. L. AU - Gam, A. A. AU - Murray, H. W. AU - Shyam Sundar JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 3 SP - 815 EP - 819 SN - 0022-1899 AD - Kenney, R. T.: Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19980806492. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 1397-89-3, 12550-17-3, 9008-11-1, 130068-27-8, 207137-56-2. Subject Subsets: Protozoology; Tropical Diseases N2 - Cytokine messenger RNA (mRNA) levels were measured in serial splenic aspirates from 27 patients with visceral leishmaniasis (Leishmania donovani) during monotherapy with interferon (IFN)-γ (9 patients), sodium antimony gluconate (SAG; 8 patients), or amphotericin B lipid complex (ABLC; 10 patients) in Varanasi, India. At baseline, mRNA for IFN-γ was detected in 18 (86%) of 21 patients, and mRNA for interleukin (IL)-10 and IL-4 was detected in 21 (100%) and 10 (48%) of 21 patients, respectively. With IFN-γ treatment alone, levels of IFN-γ mRNA decreased by day 10 and then returned to baseline levels; IL-10 mRNA levels were high throughout treatment. In the SAG and ABLC groups, levels of IFN-γ and IL-10 mRNA decreased significantly. It is concluded that polarized Th2 cell type responses do not appear to develop in Indian kala-azar; instead, there is an initial mixed Th1-Th2 cell response. With successful treatment and resolution of infection, both components of the immune response appear to involute. KW - amphotericin B KW - antimony sodium gluconate KW - antiprotozoal agents KW - cytokines KW - drug therapy KW - human diseases KW - immune response KW - interferon KW - interleukin 10 KW - interleukin 4 KW - kala azar KW - messenger RNA KW - parasites KW - spleen KW - visceral leishmaniasis KW - India KW - Leishmania donovani KW - man KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - chemotherapy KW - immunity reactions KW - immunological reactions KW - mRNA KW - sodium antimony gluconate KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806492&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. AU - Maeda, Y. AU - Venzon, D. J. AU - Mitsuya, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 5 SP - 1207 EP - 1213 SN - 0022-1899 AD - Maeda, Y.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg. 10, Rm 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982007284. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 69655-05-6, 30516-87-1. N2 - Investigations were done to determine whether the replication kinetics of HIV-1 were altered when the virus acquired a set of subsets of 5 mutations (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleosides. In the absence of drugs, the replication rate of all infectious clones generated was comparable to that of wild type HIV-1. However, in the presence of zidovudine or didanosine, the comparative order for replication was HIV-162/75/77/116/151> HIV-177/116/151> HIV-175/77/116/151~ HIV-1151, whereas that for drug resistance was HIV-175/77/116/151> HIV-162/75/77/116/151≥ HIV-177/116/151> HIV-1151. The virological features of these infectious mutants suggest that HIV-1 develops drug resistance through one or more mutations, which, however, sacrifice replicative capability; then it finally acquires optimal replication competence by additional mutations when the multi-dideoxynucleoside-resistant mutant emerges. KW - analogues KW - antiviral agents KW - CD4+ lymphocytes KW - clones KW - didanosine KW - dideoxynucleosides KW - disease course KW - drug resistance KW - drugs KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - infections KW - kinetics KW - leukocyte count KW - mutants KW - mutations KW - nucleoside analogues KW - nucleosides KW - opportunistic infections KW - proteinase inhibitors KW - proteinases KW - regimens KW - relationships KW - replication KW - susceptibility KW - treatment KW - zidovudine KW - Illinois KW - USA KW - Human immunodeficiency virus 1 KW - man KW - Retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - East North Central States of USA KW - analogs KW - AZT KW - CD4+ cells KW - cell count KW - dideoxyinosine KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - medicines KW - nucleoside analogs KW - pharmaceuticals KW - protease inhibitors KW - proteases KW - T4 lymphocytes KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007284&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines. AU - Goletti, D. AU - Weissman, D. AU - Jackson, R. W. AU - Collins, F. AU - Kinter, A. AU - Fauci, A. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 5 SP - 1332 EP - 1228 SN - 0022-1899 AD - Goletti, D.: National Institute of Allergy and Infectious Diseases, NIH, BLDG. 31, RM 7A03, Bethesda, MD 20892-2520, USA. N1 - Accession Number: 19982007286. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 308079-78-9, 102524-44-7, 85898-30-2. N2 - Coinfection with Mycobacterium tuberculosis and HIV is a serious problem, particularly in developing countries. Recently, M. tuberculosis and purified protein derivative (PPD) were demonstrated to induce HIV replication in CD8+ T-cell-depleted peripheral blood mononuclear cells from HIV-positive, PPD-positive persons but not in cells from PPD-negative persons. The role of endogenous and exogenous cytokines in modulating M. tuberculosis-induced HIV replication was evaluated. M. tuberculosis-induced HIV replication decreased following simultaneous inhibition of endogenous interleukin (IL)-2, IL-1β, and tumour necrosis factor-α by the addition of soluble receptors and receptor antagonists or following exogenous IL-10 and transforming growth factor (TGF)-β. In contrast, neutralization of endogenous IL-10 and TGF-β augmented M. tuberculosis-induced HIV replication by increasing cellular activation. Thus, the balance between IL-2 and proinflammatory and antiinflammatory cytokines plays a major role in M. tuberculosis-induced replication of HIV. KW - antigens KW - CD8+ lymphocytes KW - cytokines KW - growth factors KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - in vitro KW - inhibition KW - interleukin 2 KW - mixed infections KW - neutralization KW - pathogenesis KW - replication KW - tuberculin KW - tumour necrosis factor KW - man KW - Mycobacterium tuberculosis KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - cachectin KW - cachexin KW - CD8+ cells KW - human immunodeficiency virus KW - immunity reactions KW - immunogens KW - immunological reactions KW - multiple infections KW - purified protein derivative KW - T8 lymphocytes KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007286&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy. AU - Kavlick, M. F. AU - Wyvill, K. AU - Yarchoan, R. AU - Mitsuya, H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 177 IS - 6 SP - 1506 EP - 1513 SN - 0022-1899 AD - Kavlick, M. F.: Experimental Retrovirology Section, Medicine Branch, National Cancer Institute, Bldg 10, Rm 5A11, Bethesda, MD 20892, USA. N1 - Accession Number: 19982008411. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9068-38-6, 63231-63-0. N2 - A set of 5 reverse transcriptase mutations, which include Q151M, is known to confer multidideoxynucleoside resistance (MDR) in HIV-1. MDR mutations were found in 6 (17%) HIV-1 isolates from 36 patients, most of whom were receiving long-term combination therapy. Q151M was among the first of the substitutions to appear. Additional substitutions were observed, although none was common among all 6 patients. Certain zidovudine-related mutations were not observed together with MDR mutations, indicating possible enzymatic constraint. During chemotherapy, the HIV-1 RNA levels in the 6 patients initially decreased and then rose. Initially, CD4+ cell counts also responded favourably but were near or below baseline beyond 40 months of therapy. Such loss of clinical benefits appeared to coincide with the appearance of the MDR mutations. A common background genotype was not observed among HIV-1 isolates with or without MDR. KW - analogues KW - antiviral agents KW - CD4 antigens KW - CD4+ lymphocytes KW - clinical aspects KW - combination therapy KW - disease course KW - drug resistance KW - drug therapy KW - genotypes KW - human diseases KW - human immunodeficiency viruses KW - leukocyte count KW - mutations KW - nucleoside analogues KW - nucleosides KW - reverse transcriptase KW - RNA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analogs KW - CD4 KW - CD4+ cells KW - cell count KW - chemotherapy KW - clinical picture KW - combined modality therapy KW - disease progression KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - multimodal treatment KW - nucleoside analogs KW - ribonucleic acid KW - T4 lymphocytes KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008411&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data. AU - Ioannidis, J. P. A. AU - Collier, A. c. AU - Cooper, D. A. AU - Corey, L. AU - Fiddian, A. P. AU - Gazzard, B. G. AU - Griffiths, P. D. AU - Contopoulos-Ioannidis, D. G. AU - Lau, J. AU - Pavia, A. T. AU - Saag, M. S. AU - Spruance, S. L. AU - Youle, M. S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 2 SP - 349 EP - 359 SN - 0022-1899 AD - Ioannidis, J. P. A.: HIV Research Branch, National Institute of Allergy and Infectious Diseases, Solar Bldg., Rm 2C31, 6003 Executive Blvd., Bethesda, MD 20892, USA. N1 - Accession Number: 19982011008. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 59277-89-3. N2 - A meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (≥3200 mg/day) offered a significant survival benefit (P=0.006 by log-rank test) in HIV infection. The treatment effect did not vary significantly in patient subgroups of different CD4+ cell counts, haemoglobin levels, age, race, and sex, and with or without AIDS diagnosis. Acyclovir treatment (hazard ratio, 0.78; 95% CI 0.65-0.93), higher CD4+ cell count (P <0.001), higher haemoglobin level (P <0.001), and younger age (P<0.001) reduced the hazard of mortality. Acyclovir decreased herpes simplex virus infections (odds ratio [OR], 0.28; 95% CI, 0.21-0.37) and varicella-zoster virus infections (OR, 0.29; 95% CI, 0.1-0.63) but not cytomegalovirus disease or mortality from lymphoma or Kaposi's sarcoma. A survival advantage was seen specifically in studies with high incidence of clinical herpesvirus infections (≥25% per year). Given the wide confidence intervals, the small effect in low-risk patients, and recent changes in HIV therapeutics, the results should be interpreted cautiously, but the meta-analysis supports the importance of pathogenetic interactions between herpesviruses and HIV. KW - aciclovir KW - acquired immune deficiency syndrome KW - antiviral agents KW - CD4+ lymphocytes KW - diagnosis KW - drug therapy KW - herpes simplex KW - herpes simplex viruses KW - HIV infections KW - human diseases KW - human herpesviruses KW - human immunodeficiency viruses KW - interactions KW - Kaposi's sarcoma KW - leukocyte count KW - lymphoma KW - mortality KW - statistical analysis KW - survival KW - therapy KW - treatment KW - viral diseases KW - Cytomegalovirus KW - Herpesviridae KW - Human herpesvirus 3 KW - man KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Varicellovirus KW - Alphaherpesvirinae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - acyclovir KW - AIDS KW - CD4+ cells KW - cell count KW - chemotherapy KW - death rate KW - herpes simplex virus KW - Human herpesvirus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - statistical methods KW - T4 lymphocytes KW - therapeutics KW - Varicella-Zoster virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011008&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The influence of pregnancy on human immunodeficiency virus type 1 infection: antepartum and postpartum changes in human immunodeficiency virus type 1 viral load. AU - Burns, D. N. AU - Landesman, S. AU - Minkoff, H. AU - Wright, D. J. AU - Waters, D. AU - Mitchell, R. M. AU - Rubinstein, A. AU - Willoughby, A. AU - Goedert, J. J. JO - American Journal of Obstetrics and Gynecology JF - American Journal of Obstetrics and Gynecology Y1 - 1998/// VL - 178 IS - 2 SP - 355 EP - 359 AD - Burns, D. N.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510, USA. N1 - Accession Number: 19982005660. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 63231-63-0. N2 - The objective of this study was to examine the influence of pregnancy on HIV-1 viral load by measuring HIV-1 RNA levels during pregnancy and post partum in 160 women. Overall, HIV-1 RNA levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% CI 0.03 to 0.15 logs per year; P = 0.005). However, the mean slope during pregnancy was not significantly different from zero (P = 0.65). Thus pregnancy had little immediate effect on HIV-1 load in most HIV-1 seropositive women. KW - disease course KW - human diseases KW - human immunodeficiency viruses KW - pregnancy KW - RNA KW - viral load KW - women KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - disease progression KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005660&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hemoglobin differentially induces binding of Candida, Trichosporon, and Saccharomyces species to fibronectin. AU - Rodrigues, R. G. AU - Yan, S. AU - Walsh, T. J. AU - Roberts, D. D. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 2 SP - 497 EP - 502 SN - 0022-1899 AD - Rodrigues, R. G.: Laboratory of Pathology and Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19981202546. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Binding of fibronectin (FN) in solution to Candida, Trichosporon and Saccharomyces spp. was increased 20- to 110-fold by growth in medium containing haemoglobin, but specific adhesion to immobilized FN was increased only in C. albicans, C. tropicalis, C. krusei and C. glabrata [Torulopsis glabrata]. Haemoglobin induced both specific and non-specific binding of soluble FN. Non-specific binding accounted for all of the enhancement in Trichosporon beigelii and S. cerevisiae, but the Candida spp. possessed a saturable, high-affinity binding site for FN that was induced by haemoglobin. Induction of displaceable soluble FN binding correlated with the ability of haemoglobin to regulate adhesion to immobilized FN, since haemoglobin does not induce adhesion of S. cerevisiae or T. beigelii to immobilized FN. It is suggested that regulation by haemoglobin of FN binding to Candida spp. may therefore be an important factor in the pathogenesis of these yeast infections. KW - adhesion KW - candidosis KW - haemoglobin KW - pathogenesis KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida tropicalis KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Trichosporon beigelii KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomyces KW - Saccharomycetaceae KW - Torulopsis KW - Pezizomycotina KW - Trichosporon KW - Trichosporonaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Candida krusei KW - candidiasis KW - fibronectin KW - fungus KW - hemoglobin KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202546&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis. AU - Roilides, E. AU - Sein, T. AU - Schaufele, R. AU - Chanock, S. J. AU - Walsh, T. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 2 SP - 589 EP - 592 SN - 0022-1899 AD - Roilides, E.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981202547. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Serum levels of 2 immunosuppressive cytokines, markers of the Th2 pathway, interleukin (IL)-4 and IL-10, were measured by ELISA in 10 cancer patients from the USA with hepatosplenic candidosis (HSC) (22 samples) and compared with 19 healthy blood donors, 13 patients with cancer but no infection (23 samples), and 11 patients with cancer and various bacterial infections (17 samples). IL-4 was undetectable in all controls and patients. By contrast, levels of IL-10 were increased in HSC patients compared with levels in healthy donors and cancer patients without infection (P<0.001) or with bacterial infections (P<0.01). It is concluded that IL-10 but not IL-4 is increased in patients with hepatosplenic Candida infections and it is suggested that IL-10 plays a role in the pathogenesis of this infection. KW - candidosis KW - cytokines KW - human diseases KW - immune response KW - immunocompromised hosts KW - immunopathology KW - infections KW - interleukins KW - liver KW - neoplasms KW - opportunistic infections KW - predisposition KW - spleen KW - USA KW - Candida KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - candidiasis KW - fungus KW - Hyphomycetes KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae. AU - Pikis, A. AU - Donkersloot, J. A. AU - Rodriguez, W. J. AU - Keith, J. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 3 SP - 700 EP - 706 SN - 0022-1899 AD - Pikis, A.: Vaccine and Therapeutic Development Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982014070. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9002-03-3, 738-70-5. Subject Subsets: Public Health N2 - The molecular mechanism of trimethoprim resistance was investigated in 5 pneumococcal strains isolated in Washington, DC, USA from patients with invasive infections. Cloning and sequencing of the trimethoprim resistance determinant from these pneumococci indicated that an altered chromosome-encoded dihydrofolate reductase (DHFR) was responsible for the observed resistance. Comparison of DHFR sequences from pneumococcal strains with various susceptibilities to trimethoprim, together with site-directed mutagenesis, revealed that substitution of isoleucine-100 with a leucine residue resulted in trimethoprim resistance. Hydrogen bonding between the carbonyl oxygen of isoleucine-100 and the 4-amino group of trimethoprim is proposed to play a critical role in the inhibition of DHFR by trimethoprim. This enzyme-substrate model should facilitate the design of new antibacterial agents with improved activity against S. pneumoniae. KW - dihydrofolate reductase KW - drug resistance KW - human diseases KW - mutations KW - strains KW - trimethoprim KW - District of Columbia KW - USA KW - man KW - Streptococcus pneumoniae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Streptococcus KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - tetrahydrofolate dehydrogenase KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014070&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Abnormal regulation of interferon-γ, interleukin-12, and tumor necrosis factor-α in human interferon-γ receptor 1 deficiency. AU - Holland, S. M. AU - Dorman, S. E. AU - Kwon, A. AU - Pitha-Rowe, I. F. AU - Frucht, D. M. AU - Gerstberger, S. M. AU - Noel, G. J. AU - Vesterhus, P. AU - Brown, M. R. AU - Fleisher, T. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 4 SP - 1095 EP - 1104 SN - 0022-1899 AD - Holland, S. M.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992000702. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9008-11-1, 308079-78-9. N2 - The immunological sequelae of interferon-γ receptor ligand-binding chain (IFN-γR1) deficiency were characterized in 2 unrelated patients from the Indian subcontinent with severe disseminated nontuberculous mycobacterial infections and novel homozygous recessive IFN-γR1 mutations. In vitro, these patients' peripheral blood mononuclear cells produced 10% of normal IFN-γ and interleukin-12 (IL-12) in response to phytohaemagglutinin (PHA) but normal amounts of IFN-γ in response to PHA plus IL-12. Tumour necrosis factor (TNF)-α production was normal in response to endotoxin and to PHA but was not augmented by the addition of IFN-γ. An abnormal phenotype was not found in heterozygous patient relatives. It is concluded that the IFN-γ receptor plays a critical role in the regulation of IFN-γ, IL-12 and TNF-α. KW - bacterial diseases KW - case reports KW - cell mediated immunity KW - children KW - cytokines KW - genetic disorders KW - human diseases KW - immune response KW - immunological deficiency KW - interferon KW - interleukin 12 KW - interleukins KW - mutations KW - receptors KW - tumour necrosis factor KW - Pakistan KW - man KW - Mycobacterium KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - bacterial infections KW - bacterioses KW - bacterium KW - cachectin KW - cachexin KW - cellular immunity KW - genetic defects KW - hereditary defects KW - immune deficiency KW - immunity reactions KW - immunodeficiency KW - immunological reactions KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000702&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10. AU - Cooper, P. J. AU - Espinel, I. AU - Paredes, W. AU - Guderian, R. H. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 4 SP - 1133 EP - 1138 SN - 0022-1899 AD - Cooper, P. J.: Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990802533. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9008-11-1, 130068-27-8. Subject Subsets: Helminthology; Tropical Diseases N2 - Onchocerca volvulus infection has been associated with impaired cellular responses to parasite antigens, an impairment that may also extend to nonparasite antigens. To investigate the mechanism of this impaired immune response, the effect of concurrent O. volvulus infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied. The proliferative, cytokine, and antibody response to TT of O. volvulus-infected subjects (n = 19) and comparable non-infected controls (n = 20) from Esmeraldas Province, Ecuador, were studied before and 6 months after vaccination with TT. Following vaccination, antibody levels, proliferative responses, and levels of interferon-γ were significantly greater in non-infected subjects (P<0.05, P<0.001 and P<0.05, respectively); however, infected subjects produced interleukin-10, but non-infected controls did not (P<0.001). It is suggested that concurrent infection with O. volvulus can diminish the immune response to an unrelated antigen (TT) by a mechanism that is likely to involve interleukin-10. KW - antibodies KW - antigens KW - cytokines KW - helminths KW - human diseases KW - immune response KW - immunization KW - interferon KW - interleukin 10 KW - lymphocyte transformation KW - onchocerciasis KW - parasites KW - tetanus toxoid KW - toxoids KW - Ecuador KW - Clostridium tetani KW - man KW - Onchocerca volvulus KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - antigenicity KW - bacterium KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - river blindness KW - Secernentea KW - Spirurida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802533&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the flea. AU - Hinnebusch, B. J. AU - Fischer, E. R. AU - Schwan, T. G. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 5 SP - 1406 EP - 1415 SN - 0022-1899 AD - Hinnebusch, B. J.: National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19990500960. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 9039-53-6. Subject Subsets: Medical & Veterinary Entomology N2 - Yersinia pestis has a plasminogen activator (pla) gene on the 9.5-kb plasmid pPla that is hypothesized to play a role in producing the foregut blockage in the flea vector that precedes transmission. In this study, however, Y. pestis that lacked pPla, the 70kb virulence plasmid, or both plasmids, proved able to block Xenopsylla cheopis fleas normally. Blockage rates decreased with increasing environmental temperature for fleas infected with either wild type or pPla-Y. pestis. Thus, procoagulant ability of the Y. pestis pla gene product does not mediate blockage, nor does its ability to induce fibrinolysis at >28°C account for failure to block at elevated temperatures. A Y. pestis strain that lacked all or part of the third plasmid of 110 kb, however, failed to colonize the flea midgut normally, indicating that one or more genes on the large plasmid may be required for vector-borne transmission. KW - disease transmission KW - disease vectors KW - ectoparasites KW - genes KW - plasmids KW - plasminogen activator KW - temperature KW - virulence KW - Siphonaptera KW - Xenopsylla cheopis KW - Yersinia pestis KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Xenopsylla KW - Pulicidae KW - Siphonaptera KW - Yersinia (Bacteria) KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - Oriental rat flea KW - urokinase KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500960&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combination therapy with famciclovir and interferon-α for the treatment of chronic hepatitis B. AU - Marques, A. R. AU - Lau, D. T. Y. AU - McKenzie, R. AU - Straus, S. E. AU - Hoofnagle, J. H. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 5 SP - 1483 EP - 1487 SN - 0022-1899 AD - Marques, A. R.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19992001650. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9008-11-1, 104227-87-4. Subject Subsets: Public Health N2 - Five adults with chronic HBV infection in whom previous interferon-α (IFN-α) therapy had failed were treated in a pilot study [in the USA] of overlapping IFN-α and famciclovir therapy totalling 20 weeks. HBV DNA levels decreased by 0.9 log units during the initial 4-week period of famciclovir alone, followed by a further decrease of 1.8 logs during the middle 12-week period of combination therapy. HBV DNA rose by 0.9 log during the final 4-week period of IFN-α alone. Two patients cleared HBV DNA, and their liver disease improved by clinical and histological criteria. The combination of famciclovir and IFN-α appeared to be at least additive in suppressing HBV DNA. It is concluded that efficacy trials of combination therapy with famciclovir and IFN-α are warranted. KW - clinical aspects KW - combination therapy KW - drug combinations KW - drug therapy KW - famciclovir KW - hepatitis B KW - human diseases KW - interferon KW - Maryland KW - USA KW - hepatitis B virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - clinical picture KW - combined modality therapy KW - multimodal treatment KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001650&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interferon-γ and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis. AU - Neva, F. A. AU - Oliveira Filho, J. AU - Gam, A. A. AU - Thompson, R. AU - Freitas, V. AU - Melo, A. AU - Carvalho, E. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1998/// VL - 178 IS - 6 SP - 1856 EP - 1859 SN - 0022-1899 AD - Neva, F. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990802436. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2. Subject Subsets: Helminthology; Tropical Diseases N2 - A study was carried out in Brazil to investigate the interaction between infection with human T lymphotropic virus type 1 (HTLV-1) and Strongyloides stercoralis in individuals infected with one or both agents. The cytokine responses of peripheral blood mononuclear cells (PBMC) to mitogens and Strongyloides antigen were studied. PBMC of subjects infected with HTLV-1 spontaneously produced interferon (IFN)-γ with levels that correlated inversely with serum IgE levels. HTLV-1-infected subjects also had poor interleukin (IL)-4 responses to mitogenic stimulation, unlike persons without HTLV-1 infection. It is postulated that the IFN-γ produced by activated T cells in some HTLV-1-infected persons acts to down-regulate IL-4 with consequent reduction of serum IgE levels. It is suggested that the impaired IgE responses and other effects of IL-4 down-regulation may be contributing factors to more severe disease and impaired response to treatment of strongyloidiasis in some HTLV-1-infected persons. KW - antigens KW - cytokines KW - helminths KW - HTLV infections KW - human diseases KW - IgE KW - immune response KW - immunocompromised hosts KW - interactions KW - interferon KW - interleukin 4 KW - mixed infections KW - opportunistic infections KW - parasites KW - strongyloidiasis KW - T lymphocytes KW - Brazil KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Rhabditida KW - Strongyloides stercoralis KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Strongyloides KW - Strongyloididae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - antigenicity KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - immunity reactions KW - immunogens KW - immunological reactions KW - multiple infections KW - nematodes KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Secernentea KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802436&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. AU - Tsai HuieFung AU - Chang, Y. C. AU - Washburn, R. G. AU - Wheeler, M. H. AU - Kwon-Chung, K. J. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1998/// VL - 180 IS - 12 SP - 3031 EP - 3038 SN - 0021-9193 AD - Tsai HuieFung: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201965. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Medical & Veterinary Mycology N2 - An A. fumigatus gene, alb1, which is required for conidial pigmentation was identified. The alb1 gene encodes a putative polyketide synthase and disruption of alb1 resulted in an albino conidial phenotype. Expression of alb1 is developmentally regulated and the 7-kb transcript is detected only during the conidiation stage. The alb1 mutation was found to block 1,3,6,8-tetrahydroxynaphthalene production, indicating that alb1 is involved in dihydroxynaphthalene-melanin biosynthesis. Scanning electron microscopy studies showed that the alb1 disruptant exhibited a smooth conidial surface, whereas complementation of the alb1 deletion restored the echinulate wild-type surface. Disruption of alb1 resulted in a significant increase in C3 binding on conidial surfaces and the conidia of the alb1 disruptant were ingested by human neutrophils at a higher rate than were those of the wild type. The alb1-complemented strain producing bluish-green conidia exhibited inefficient C3 binding and neutrophil-mediated phagocytosis quantitatively similar to those of the wild type. The alb1 disruptant had a statistically significant loss of virulence compared with the wild-type and alb1-complemented strains in a murine model. It is suggested that disruption of alb1 causes pleiotropic effects on conidial morphology and fungal virulence. KW - aspergillosis KW - experimental infections KW - genes KW - infections KW - morphology KW - pathogenicity KW - virulence KW - Aspergillus fumigatus KW - mice KW - Aspergillus KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201965&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA. AU - Stevenson, B. AU - Bono, J. L. AU - Elias, A. AU - Tilly, K. AU - Rosa, P. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1998/// VL - 180 IS - 18 SP - 4850 EP - 4855 SN - 0021-9193 AD - Stevenson, B.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19990501774. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology N2 - A method was developed by which heterologous DNA (DNA without a naturally occurring B. burgdorferi homologue) can be introduced into and persistently maintained by B. burgdorferi. This technique uses integration of circular DNA into the bacterial genome via a single-crossover event. The ability to transform B. burgdorferi with heterologous DNA will now permit a wide range of experiments on the biology of these bacteria and their involvement in the many facets of Lyme disease. KW - biotechnology KW - genomes KW - molecular genetics KW - plasmids KW - transformation KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - biochemical genetics KW - cloning KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990501774&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signalling. AU - Jankovic, D. AU - Cheever, A. W. AU - Kullberg, M. C. AU - Wyn, T. A. AU - Yap, G. AU - Caspar, P. AU - Lewis, F. A. AU - Clynes, R. AU - Ravetch, J. V. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 187 IS - 4 SP - 619 EP - 629 SN - 0022-1007 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19980803156. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Helminthology N2 - The pathogenesis of schistosomiasis was studied in B cell deficient µMT mice infected with Schistosoma mansoni (Puerto Rican strain) by exposure of the tail to cercariae. The mice developed augmented tissue pathology and failed to undergo the spontaneous downmodulation in disease normally observed during late stages of infection. Unexpectedly, B cell deficiency did not significantly alter the T cell proliferative response or cause a shift in the Th1/Th2 balance. Since schistosome-infected Fc receptor-deficient (FcR γ chain knockout) mice displayed the same exacerbated egg pathology as that observed in infected µMT mice, it is suggested that the B cell-dependent regulatory mechanism revealed by these experiments requires receptor-mediated cell triggering. It is concluded that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells. KW - B lymphocytes KW - experimental infections KW - granuloma KW - helminths KW - immunopathology KW - laboratory animals KW - parasites KW - pathology KW - schistosomiasis KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - B cells KW - bilharzia KW - bilharziasis KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803156&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with Histoplasma capsulatum. AU - Ping Zhou AU - Seder, R. A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 187 IS - 8 SP - 1315 EP - 1324 SN - 0022-1007 AD - Ping Zhou: Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19981201629. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The role of CD40 ligand (CD40L) in mediating protection against infection with H. capsulatum was investigated using CD40L-deficient (CD40L-/-) and CD40L+/+ mice. Animals were infected with H. capsulatum and assessed for various parameters. After a lethal challenge of H. capsulatum, CD40L-/- mice were not substantially different from CD40L+/+ mice in terms of mortality, fungal burden or production of interferon-γ (IFN-γ), interleukin 12 (IL-12), nitric oxide or tumour necrosis factor α. Moreover, CD40L-/- mice treated with anti-IFN-γ or anti-IL-12 at the time of infection had accelerated mortality, providing further evidence that IL-12 and IFN-γ are produced in vivo in the absence of CD40L. In addition, CD40L-/- mice infected with a sublethal dose of H. capsulatum survived infection, whereas all mice infected with the same dose and treated with anti-IFN-γ had accelerated mortality, demonstrating that IFN-γ but not CD40L was essential for primary immunity to H. capsulatum infection. Depletion of either CD4+ or CD8+ T cells resulted in accelerated mortality in CD40L-/- mice, suggesting a critical role for these cells in response to infection. Finally, CD40L-/- mice initially infected with a sublethal dose of H. capsulatum were protected from secondary infection with a lethal dose of H. capsulatum, demonstrating that CD40L is not required for the maintenance of memory immunity. KW - cytokines KW - experimental infections KW - histoplasmosis KW - immune response KW - immunity KW - infections KW - Histoplasma capsulatum KW - mice KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Histoplasma KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Ajellomyces capsulatus KW - fungus KW - immunity reactions KW - immunological reactions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201629&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adherence of erythrocytes during exflagellation of Plasmodium falciparum microgametes is dependent on erythrocyte surface sialic acid and glycophorins. AU - Templeton, T. J. AU - Keister, D. B. AU - Muratova, O. AU - Procter, J. L. AU - Kaslow, D. C. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 187 IS - 10 SP - 1599 EP - 1609 SN - 0022-1007 AD - Templeton, T. J.: Malaria Vaccines Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19990804796. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Protozoology N2 - Male Plasmodium gametocytes within a newly ingested infected blood meal in the mosquito midgut emerge from erythrocytes and extrude approximately 8 flagellar microgametes (exflagellation). In culture, and in blood removed from infected patients, emerging microgametes avidly adhere to neighbouring uninfected and infected erythrocytes, as well as to emerged female macrogametes. The proposition of a function underlying erythrocyte adherence is supported by the observation of species-specificity in adhesion: microgametes of P. falciparum can bind human but not chicken erythrocytes, whereas P. gallinaceum microgametes bind chicken but not human erythrocytes. A binding assay was developed in which normal, enzyme-treated, variant or null erythrocytes were identified by a cell surface fluorescent label and assayed for adherence to exflagellating microgametes. Neuraminidase, trypsin or ficin treatment of human erythrocytes eliminated the ability to adhere to P. falciparum microgametes, suggesting a role of sialic acid and one or more glycophorins in the binding to a putative gamete receptor. Using nulls lacking glycophorin A [En(a-)], glycophorin B (S-s-U-) or a combination of glycophorin A and B (Mk/Mk), it was shown that erythrocytes lacking glycophorin B retain the ability to bind but a lack of glycophorin A reduced adherence by exflagellating microgametes. It is proposed that either the sialic acid moiety of glycophorins, predominantly glycophorin A, or a more complex interaction involving the glycophorin peptide backbone, is the erythrocyte receptor for adhesion to microgametes. KW - assays KW - binding KW - cytoadherence KW - development KW - developmental stages KW - erythrocytes KW - gametes KW - host parasite relationships KW - parasites KW - receptors KW - reproduction KW - Plasmodium KW - Plasmodium falciparum KW - protozoa KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - blood red cells KW - cell adhesion KW - glycophorins KW - growth phase KW - microgametes KW - parasite host relationships KW - red blood cells KW - sialic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804796&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of HIV-1 replication in latently infected CD4+ cells using a combination of cytokines. AU - Chun, T. W. AU - Engel, D. AU - Mizell, S. B. AU - Ehler, L. A. AU - Fauci, A. S. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 188 IS - 1 SP - 83 EP - 91 SN - 0022-1007 AD - Chun, T. W.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bldg 10, Rm 6A32, Bethesda, MD 20892, USA. N1 - Accession Number: 19982010886. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 308079-78-9. N2 - Although it has been demonstrated that certain cytokines, particularly proinflammatory cytokines, can enhance ongoing viral replication in peripheral blood mononuclear cells (PBMCs) of HIV-1-infected individuals, it is unclear what role these cytokines play in the induction of HIV-1 replication in latently infected, resting CD4+ T cells. This study demonstrates that the in vitro combination of the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α together with the immunoregulatory cytokine IL-2 are potent inducers of viral replication in highly purified, latently infected, resting CD4+ T cells derived from HIV-infected individuals who are antiretroviral therapy-naive as well as those who are receiving highly active antiretroviral therapy (HAART). Viral replication induced by this combination of cytokines was completely suppressed in the presence of HAART in vitro. Given that an array of cytokines, including IL-6, TNF-α, and IL-2, are copiously expressed in the microenvironment of the lymphoid tissues, which harbour the latent viral reservoirs, induction of HIV by this combination of cytokines may in part explain the commonly observed reappearance of detectable plasma viraemia in HIV-infected individuals in whom HAART was discontinued. Moreover, since it is likely that these infected cells die upon activation of virus and that HAART prevents spread of virus to adjacent cells, the observation that this combination of cytokines can markedly induce viral replication in this reservoir may have important implications for the activation-mediated diminution of the latent reservoir of HIV in patients receiving HAART. KW - antiviral agents KW - blood plasma KW - CD4+ lymphocytes KW - combination therapy KW - cytokines KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - in vitro KW - interleukins KW - pathogenesis KW - replication KW - T lymphocytes KW - tumour necrosis factor KW - viral replication KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cachectin KW - cachexin KW - CD4+ cells KW - chemotherapy KW - combined modality therapy KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - multimodal treatment KW - plasma (blood) KW - T cells KW - T4 lymphocytes KW - tumor necrosis factor KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010886&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. AU - Stebut, E. von AU - Belkaid, Y. AU - Jakob, T. AU - Sacks, D. L. AU - Udey, M. C. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 188 IS - 8 SP - 1547 EP - 1552 SN - 0022-1007 AD - Stebut, E. von: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 12N238, 9000 Rockville Pike, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19990802537. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology N2 - Using Langerhans cell (LC)-like dendritic cells (DC) expanded from C57BL/6 fetal skin, interactions involving several developmental stages of Leishmania and DC were characterized. It was confirmed that L. major amastigotes, but not promastigotes, efficiently entered LC-like DCs. Parasite internalization was associated with activation manifested by upregulation of major histocompatibility complex (MHC) class I and II surface antigens, increased expression of costimulatory molecules (CD40, CD54, CD80 and CD86), and IL-12 p40 release within 18 h. L. major-induced IL-12 p70 release by DC required interferon-γ and prolonged (72 h) incubation. In contrast, infection of inflammatory macrophages with amastigotes or promastigotes did not lead to significant changes in surface antigen expression or cytokine production. The results suggest that skin macrophages and DC are infected sequentially in cutaneous leishmaniasis and that they play distinct roles in the inflammatory and immune response initiated by L. major. Macrophages capture organisms near the site of inoculation early in the course of infection after establishment of cellular immunity, and kill amastigotes but probably do not actively participate in T cell priming. In contrast, skin DC are induced to express increased amounts of MHC antigens and costimulatory molecules and to release cytokines (including IL-12 p70) by exposure to L. major amastigotes that ultimately accumulate in lesional tissue, and thus very likely initiate protective T helper cell type 1 immunity. KW - amastigotes KW - cytokines KW - immune response KW - immunity KW - interferon KW - interleukin 12 KW - macrophages KW - major histocompatibility complex KW - parasites KW - promastigotes KW - skin KW - surface antigens KW - T lymphocytes KW - Leishmania major KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - dermis KW - histocompatibility complex KW - immunity reactions KW - immunological reactions KW - Langerhans cells KW - metacyclic forms KW - T cells KW - T helper cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802537&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. AU - Belkaid, Y. AU - Kamhawi, S. AU - Modi, G. AU - Valenzuela, J. AU - Noben-Trauth, N. AU - Rowton, E. AU - Ribeiro, J. AU - Sacks, D. L. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1998/// VL - 188 IS - 10 SP - 1941 EP - 1953 SN - 0022-1007 AD - Belkaid, Y.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990801600. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 207137-56-2. Subject Subsets: Protozoology N2 - A model of cutaneous leishmaniasis due to Leishmania major was developed that attempts to mimic the natural conditions of infection. 1000 metacyclic promastigotes were coinoculated with a salivary gland sonicate (SGS) obtained from Phlebotomus papatasi into the ear dermis of naive mice or of mice pre-exposed to SGS. The study revealed a dramatic exacerbating effect of SGS on lesion development in the dermal site and a complete abrogation of this effect in mice pre-exposed to salivary components. In both BALB/c and C57B1/6 (B/6) mice, the dermal lesions appeared earlier, were more destructive and contained greater numbers of parasites after infection in the presence of SGS. Furthermore, coinoculation of SGS converted B/6 mice into a nonhealing phenotype. No effect of SGS was seen in either interleukin (IL)-4-deficient or in SCID mice. Disease exacerbation in both BALB/c and B/6 mice was associated with an early (6 h) increase in the frequency of epidermal cells producing Th2 cytokines. SGS did not elicit Th2 cytokines in the epidermis of mice previously injected with SGS. These mice made antisaliva antibodies that were able to neutralize the ability of SGS to enhance infection and to elicit IL-4 and IL-5 responses in the epidermis. The results suggest that a history of exposure to vector saliva for individuals at risk of vector-borne infections might influence the outcome of exposure to transmitted parasites. KW - cutaneous leishmaniasis KW - cytokines KW - disease models KW - ears KW - epidermis KW - experimental infections KW - extracts KW - immune response KW - interactions KW - interleukin 4 KW - interleukin 5 KW - laboratory animals KW - parasites KW - pathogenesis KW - promastigotes KW - saliva KW - salivary glands KW - skin KW - skin diseases KW - skin lesions KW - T lymphocytes KW - vector-borne diseases KW - Leishmania major KW - mice KW - Phlebotomus papatasi KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Phlebotomus KW - Phlebotominae KW - Psychodidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - dermatoses KW - dermis KW - immunity reactions KW - immunological reactions KW - salivary secretions KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990801600&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification and cloning of the salivary nitrophorin from the hemipteran Cimex lectularius. AU - Valenzuela, J. G. AU - Ribeiro, J. M. C. JO - Journal of Experimental Biology JF - Journal of Experimental Biology Y1 - 1998/// VL - 201 IS - 18 SP - 2659 EP - 2664 SN - 0022-0949 AD - Valenzuela, J. G.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19980506636. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 87-89-8, 10102-43-9. Subject Subsets: Medical & Veterinary Entomology N2 - The salivary nitrophorin of C. lectularius was purified by DEAE chromatography and reverse-phase high-performance liquid chromatography. The purified nitrophorin had a molecular mass of 32.9 kDa. The DEAE-purified haemoprotein was able to bind nitric oxide (NO), and this binding shifted the absorption maximum from 388 nm to 438 nm. The ratio of haem to apoprotein was estimated to be of 1:1. A cDNA clone of 1079 base pairs was sequenced and was found to code for a protein with a molecular mass of 31.7 kDa. The clone sequence was in agreement with the internal peptide sequences obtained from the purified protein. Sequencing of the isolated clone indicates high similarity to several inositol phosphatases; however, no significant similarities emerged when the sequence of C. lectularius nitrophorin was compared with that of R. prolixus nitrophorin, the only other nitrophorin known in insect saliva. Since C. lectularius and R. prolixus belong to two different families of Hemiptera that evolved independently to blood feeding, a case is made for the convergent evolution of these two insect nitrophorins. KW - amino acid sequences KW - biochemistry KW - complementary DNA KW - molecular genetics KW - myo-inositol KW - nitric oxide KW - nucleotide sequences KW - proteins KW - purification KW - saliva KW - salivary glands KW - Cimex lectularius KW - Cimicidae KW - Hemiptera KW - Rhodnius prolixus KW - Cimex KW - Cimicidae KW - Heteroptera KW - Hemiptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Rhodnius KW - Triatominae KW - Reduviidae KW - bed bug KW - biochemical genetics KW - cDNA KW - DNA sequences KW - inositol KW - meso-inositol KW - nitrophorins KW - protein sequences KW - salivary secretions KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506636&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The Ld Cht1 gene encodes the secretory chitinase of the human pathogen Leishmania donovani. AU - Shakarian, A. M. AU - Dwyer, D. M. JO - Gene JF - Gene Y1 - 1998/// VL - 208 IS - 2 SP - 315 EP - 322 SN - 0378-1119 AD - Shakarian, A. M.: Cell Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990805414. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9001-06-3. Subject Subsets: Protozoology N2 - Leishmania donovani promastigotes were shown to release chitinase activity during growth in vitro. A polymerase chain reaction (PCR)-based strategy identified a single copy open reading frame capable of encoding the L. donovani chitinase (Ld Chtl, 1374 bp). Ld Chtl was shown to be actively transcribed by L. donovani promastigotes using reverse transcription and PCR amplification. The deduced amino acid sequence of Ld Chtl showed high conservation to known chitinases including the putative active and 2 substrate binding sites. Antiserum generated against 4 peptides derived from its deduced amino acid sequence immunoprecipitated an ~ 50-kDa in vitro transcription/translation product of Ld Chtl. This antiserum also immunoprecipitated both the native L. donovani 50-kDa Chtl protein and the native chitinase activity synthesized and released by these parasites. KW - amino acid sequences KW - binding KW - chitinase KW - DNA amplification KW - enzyme activity KW - enzymes KW - genes KW - in vitro KW - molecular genetics KW - open reading frames KW - parasites KW - polymerase chain reaction KW - promastigotes KW - reverse transcription KW - transcription KW - Leishmania donovani KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA transcription KW - immunoprecipitation KW - ORFs KW - PCR KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Advances in prevention and treatment of infectious complications in children and adolescents with cancer. / Fortschritte in Prävention und Therapie infektiöser Komplikationen bei Kindern und Jugendlichen mit neoplastischen Erkrankungen. AU - Groll, A. H. AU - Müller, F. M. C. JO - Klinische Pädiatrie JF - Klinische Pädiatrie Y1 - 1998/// VL - 210 IS - 3 SP - 106 EP - 114 SN - 0300-8630 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19992000992. Publication Type: Journal Article. Language: German. Language of Summary: English. Number of References: 34 ref. N2 - This article first delineates both clinical approach and current treatment strategies in the paediatric cancer patient presenting with neutropenia and fever of unknown origin. Diagnosis and treatment of the most common specific infections (caused by bacteria, fungi and viruses) are reviewed and preventive measures in the setting of anticancer treatment are discussed. KW - adolescents KW - bacterial diseases KW - children KW - clinical aspects KW - complications KW - diagnosis KW - disease prevention KW - fever KW - human diseases KW - immunocompromised hosts KW - mycoses KW - neoplasms KW - neutropenia KW - opportunistic infections KW - reviews KW - treatment KW - viral diseases KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - cancers KW - clinical picture KW - pyrexia KW - teenagers KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000992&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lipid formulations of amphotericin B: clinical perspectives for the management of invasive fungal infections in children with cancer. AU - Groll, A. H. AU - Müller, F. M. C. AU - Piscitelli, S. C. AU - Walsh, T. J. JO - Klinische Pädiatrie JF - Klinische Pädiatrie Y1 - 1998/// VL - 210 IS - 4 SP - 264 EP - 273 SN - 0300-8630 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991200565. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 86 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The clinical pharmacokinetics, safety and efficacy of lipid formulations of amphotericin B are reviewed with special emphasis on paediatric data. A rational framework is provided for the determination of the current role of these formulations in patients with cancer and proven or suspected invasive fungal infections. KW - amphotericin B KW - application methods KW - children KW - drug formulations KW - drug therapy KW - efficacy KW - immunocompromised hosts KW - lipids KW - mycoses KW - neoplasms KW - opportunistic infections KW - pharmacokinetics KW - reviews KW - safety KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - chemotherapy KW - lipins KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200565&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of Friend virus replication by a compound that reacts with the nucleocapsid zinc finger: anti-retroviral effect demonstrated in vivo. AU - Ott, D. E. AU - Hewes, S. M. AU - Alvord, W. G. AU - Henderson, L. E. AU - Arthur, L. O. JO - Virology (New York) JF - Virology (New York) Y1 - 1998/// VL - 243 IS - 2 SP - 283 EP - 292 SN - 0042-6822 AD - Ott, D. E.: AIDS Vaccine Program, SAIC/Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 211702-1201, USA. N1 - Accession Number: 19982006900. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 7440-66-6. KW - antiviral properties KW - coat proteins KW - human diseases KW - nucleocapsid proteins KW - replication KW - viral replication KW - zinc KW - Murine leukemia virus KW - Retroviridae KW - viruses KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - anti-viral properties KW - capsid proteins KW - murine leukaemia virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006900&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polymorphism in the 3′ untranslated region of MTG8 is associated with obesity in Pima Indian males. AU - Wolford, J. K. AU - Bogardus, C. AU - Prochazka, M. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1998/// VL - 246 IS - 3 SP - 624 EP - 626 SN - 0006-291X AD - Wolford, J. K.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19991402247. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition KW - anthropometric dimensions KW - ethnic groups KW - genes KW - genetic polymorphism KW - genetics KW - obesity KW - polymorphism KW - sex differences KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anthropometric measurements KW - fatness KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991402247&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunoprotective determinants in Friend murine leukemia virus envelope protein. AU - Hasenkrug, K. J. AU - Brooks, D. M. AU - Robertson, M. N. AU - Srinivas, R. V. AU - Chesebro, B. JO - Virology (New York) JF - Virology (New York) Y1 - 1998/// VL - 248 IS - 1 SP - 66 EP - 73 SN - 0042-6822 AD - Hasenkrug, K. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH903 South 4th St., Hamilton, MT 59840, USA. N1 - Accession Number: 19982012125. Publication Type: Journal Article. Language: English. Number of References: 44 ref. KW - animal models KW - envelope proteins KW - human diseases KW - human immunodeficiency viruses KW - immunity KW - immunization KW - protection KW - vaccines KW - man KW - Murine leukemia virus KW - Retroviridae KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Gammaretrovirus KW - human immunodeficiency virus KW - immune sensitization KW - murine leukaemia virus KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012125&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mapping of a neurovirulence determinant within the envelope protein of a polytropic murine retrovirus: induction of central nervous system disease by low levels of virus. AU - Poulsen, D. J. AU - Robertson, S. J. AU - Favara, C. A. AU - Portis, J. L. AU - Chesebro, B. W. JO - Virology (New York) JF - Virology (New York) Y1 - 1998/// VL - 248 IS - 2 SP - 199 EP - 207 SN - 0042-6822 AD - Poulsen, D. J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 South 4th Street, Hamilton, MT 59840, USA. N1 - Accession Number: 19982013910. Publication Type: Journal Article. Language: English. Number of References: 41 ref. KW - central nervous system KW - ENV gene KW - envelope proteins KW - nervous system KW - pathogenesis KW - virulence KW - Murine leukemia virus KW - Retroviridae KW - Gammaretrovirus KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - CNS KW - murine leukaemia virus KW - Human Physiology and Biochemistry (VV050) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013910&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Macaques infected with cloned simian immunodeficiency virus show recurring nef gene alterations. AU - Heidecker, G. AU - Muñoz, H. AU - Lloyd, P. AU - Hodge, D. AU - Ruscetti, F. W. AU - Morton, W. R. AU - Hu, S. L. AU - Benveniste, R. E. JO - Virology (New York) JF - Virology (New York) Y1 - 1998/// VL - 249 IS - 2 SP - 260 EP - 274 SN - 0042-6822 AD - Heidecker, G.: Intramural Research Support Program, SIAC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. N1 - Accession Number: 19982014298. Publication Type: Journal Article. Language: English. Number of References: 63 ref. N2 - The molecular clone of SIV/Mne used in this study has no obvious inactivating mutations in the nef gene and was obtained from a single-cell clone of infected Hut 78 cells that produced high levels of infectious virus. It was hypothesized that the virus had acquired attenuating missense mutations in nef, which should be reverted in vivo, thus highlighting residues that are important for Nef function. To test this hypothesis, nef sequences obtained from macaques that had been inoculated with biologically (single-cell clone) or molecularly cloned SIV/Mne were analysed. It was found that 5 Nef residues had undergone consistent substitutions in almost all sequences isolated late in infection from the animal studied. In addition, other residues were found to have changed in more than one animal. The macaque-adapted nef conferred increased infectivity to the virus, but mutated versions rapidly accumulated in a tissue culture environment. KW - animal models KW - human diseases KW - mutations KW - NEF gene KW - tissue culture KW - Human immunodeficiency virus 1 KW - Macaca KW - simian immunodeficiency virus KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus type 1 KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014298&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba. AU - Wang Jian AU - Villeneuve, S. AU - Zhang Jian AU - Lei PingSheng AU - Miller, C. E. AU - Lafaye, P. AU - Nato, F. AU - Szu, S. C. AU - Karpas, A. AU - Bystricky, S. AU - Robbins, J. B. AU - Kováč, P. AU - Fournier, J. M. AU - Glaudemans, C. P. J. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1998/// VL - 273 IS - 5 SP - 2777 EP - 2783 SN - 0021-9258 AD - Wang Jian: Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19982007552. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 308067-58-5. Subject Subsets: Tropical Diseases N2 - Monoclonal antibodies (IgG1s S-20-4, A-20-6 and IgA 2D6) directed against V. cholerae O1 Ogawa-lipopolysaccharide (LPS) exhibited the same fine specificities and similar affinities for synthetic mono- to hexasaccharides which mimicked the Ogawa O-polysaccharide (O-PS). They did not react with the corresponding synthetic fragments of Inaba O-PS. Binding studies using derivatives of the Ogawa monosaccharide and IgGs S-20-4 and A-20-6 revealed that the C-2 O-methyl group fits into a somewhat flexible antibody cavity and that hydrogen bonds involving the oxygen and, respectively, the OH at the 2- and 3-position of the sugar moiety as well as the 2′-position in the amide side chain are required. Monoclonal IgA ZAC-3 and IgG3 I-24-2 are specific for V. cholerae O1 serotypes Ogawa/Inaba-LPS. The former did not show binding with members of either series of the synthetic ligands related to the O-antigens of the Ogawa or Inaba serotypes, in agreement with its reported specificity for the lipid/core region. Inhibition studies revealed that the binding of purified IgG3 I-24-2 to Ogawa-LPS might be mediated by a region in the junction of the OPS to the lipid-core region of the LPS. cDNA cloning and analysis of the anti-Ogawa antibodies S-20-4, A-20-6, and 2D6 revealed a very high degree of homology among the heavy chains. Among the light chains, no such homology between S-20-4 and A-20-6 on the one hand, and 2D6 on the other hand, existed. For the anti-Inaba/Ogawa antibodies I-24-2 and ZAC-3, heavy chains were completely different, with some homology among the light chains. KW - antibodies KW - antigens KW - bacterial antigens KW - bacterial diseases KW - epitopes KW - human diseases KW - IgA KW - IgG KW - immunology KW - lipopolysaccharides KW - monoclonal antibodies KW - serotypes KW - Vibrio cholerae KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - antigenic determinants KW - antigenicity KW - bacterial infections KW - bacterioses KW - bacterium KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007552&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hemoglobin induces binding of several extracellular matrix proteins to Candida albicans. Identification of a common receptor for fibronectin, fibrinogen, and laminin. AU - Yan SiZhuang AU - Rodrigues, R. G. AU - Cahn-Hidalgo, D. AU - Walsh, T. J. AU - Roberts, D. D. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1998/// VL - 273 IS - 10 SP - 5638 EP - 5644 SN - 0021-9258 AD - Yan SiZhuang: Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19981201961. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Haemoglobin induced binding of laminin, fibrinogen and type IV collagen but not of thrombospondin-1 or type I collagen to C. albicans is reported. The binding of each protein was inhibited by the respective unlabelled ligand in a concentration-dependent manner. Fibrinogen inhibited the binding of radiolabelled fibronectin, laminin and fibrinogen with similar IC50 values, indicating that a single promiscuous receptor recognises these 3 proteins. Competitive binding studies demonstrated that a second class of receptor binds specifically to laminin. Growth of C. albicans in the presence of haemoglobin also increased cell adhesion to immobilized fibronectin, laminin, fibrinogen and type IV collagen but not to thrombospondin-1 or type I collagen. Exposure to haemoglobin induced increased or de novo expression of several surface proteins on C. albicans. One of these proteins with a molecular weight of 55 000 recognised fibronectin, based on ligand protection and affinity chromatography on immobilized fibronectin. It is concluded that haemoglobin induces both promiscuous and specific receptors for extracellular matrix proteins and, therefore, may regulate matrix adhesion during dissemination of C. albicans infections. KW - adhesion KW - candidosis KW - collagen KW - haemoglobin KW - matrix proteins KW - pathogenesis KW - Candida albicans KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - candidiasis KW - fibronectin KW - fungus KW - hemoglobin KW - Hyphomycetes KW - laminin KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201961&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat. AU - Benkirane, M. AU - Chun, R. F. AU - Xiao Hua AU - Ogryzko, V. V. AU - Howard, B. H. AU - Nakatani, Y. AU - Jeang KuanTeh JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1998/// VL - 273 IS - 38 SP - 24898 EP - 24905 SN - 0021-9258 AD - Benkirane, M.: Bldg. 4, Rm. 306, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19982013769. Publication Type: Journal Article. Language: English. Number of References: 90 ref. Registry Number: 63231-63-0. N2 - This study shows that a nuclear histone acetyltransferase activity associates with Tat. Intracellularly, Tat formed a ternary complex with p300 and P/CAF, 2 histone acetyltransferases (HATs). A murine cell defect in Tat transactivation of the HIV-1 LTR was linked to the reduced abundance of p300 and P/CAF. Thus, overexpression of p300 and P/CAF reconstituted Tat transactivation of the HIV-1 LTR in NIH3T3 cells to a level similar to that observed for human cells. By the use of transdominant p300 or P/CAF mutants that lack enzymatic activity, a requirement was delineated for the HAT component from the latter but not the former in Tat function. Finally, it was observed that Tat-associated HAT is preferentially important for transactivation of integrated, but not integrated, HIV-1 LTR. KW - chromosomes KW - hosts KW - human diseases KW - integration KW - mutants KW - proviruses KW - RNA KW - Tat protein KW - transactivation KW - transcription KW - Human immunodeficiency virus 1 KW - Retroviridae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - DNA transcription KW - histone acetyltransferase KW - human immunodeficiency virus type 1 KW - ribonucleic acid KW - transcriptional activation KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013769&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius: a new type of nucleotide-binding enzyme. AU - Valenzuela, J. G. AU - Charlab, R. AU - Galperin, M. Y. AU - Ribeiro, J. M. C. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1998/// VL - 273 IS - 46 SP - 30583 EP - 30590 SN - 0021-9258 AD - Valenzuela, J. G.: Medical Entomology Section, Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Rm. 126, 4 Center Dr., MSC 0425, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990500651. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Entomology N2 - An enzyme that hydrolyzes the phosphodiester bonds of nucleoside tri- and diphosphates, but not monophosphates, thus displaying apyrase (EC 3.6.1.5) activity, was purified from salivary glands of C. lectularius. The purified C. lectularius apyrase was an acidic protein with a pI of 5.1 and molecular mass of ~40 kDa that inhibited ADP-induced platelet aggregation and hydrolyzed platelet agonist ADP with specific activity of 379 units/mg protein. Amplification of C. lectularius cDNA corresponding to the N-terminal sequence of purified apyrase produced a probe that allowed identification of a 1.3 kilobase pair cDNA clone coding for a protein of 364 amino acid residues, the first 35 of which constituted the signal peptide. The processed form of the protein was predicted to have a molecular mass of 37.5 kDa and pI of 4.95. The identity of the product of the cDNA clone with native C. lectularius apyrase was proved by immunological testing and by expressing the gene in a heterologous host. Immune serum made against a synthetic peptide with sequence corresponding to the C-terminal region of the predicted cDNA clone recognized both C. lectularius apyrase fractions eluted from a molecular sieving high pressure liquid chromatography and the apyrase active band from chromatofocusing gels. Furthermore, transfected COS-7 cells secreted a Ca2+-dependent apyrase with a pI of 5.1 and immunoreactive material detected by the anti-apyrase serum. C. lectularius apyrase has no significant sequence similarity to any other known apyrases, but homologous sequences have been found in the genome of Caenorhabditis elegans and in mouse and human expressed sequence tags from foetal and tumour EST libraries. KW - amino acid sequences KW - clones KW - complementary DNA KW - enzymes KW - gene expression KW - genomes KW - molecular genetics KW - nucleotide sequences KW - salivary glands KW - Cimex lectularius KW - Cimicidae KW - Hemiptera KW - Cimex KW - Cimicidae KW - Heteroptera KW - Hemiptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - apyrase KW - bed bug KW - biochemical genetics KW - cDNA KW - cloning KW - DNA sequences KW - protein sequences KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500651&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Strain-dependent differences in β-sheet conformations of abnormal prion protein. AU - Caughey, B. AU - Raymond, G. J. AU - Bessen, R. A. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1998/// VL - 273 IS - 48 SP - 32230 EP - 32235 SN - 0021-9258 AD - Caughey, B.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA. N1 - Accession Number: 19992202865. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - Strain diversity in transmissible spongiform encephalopathies (TSEs) is thought to be caused by variations in the conformation of the abnormal, protease-resistant form of prion protein (PrP-res). The infection of hamsters with three TSE strains was investigated to see if it resulted in the formation of PrP-res with different conformations using limited proteinase K (PK) digestion and infrared spectroscopy. PrP-res isolated from the brains of hamsters infected with the hyper (HY), drowsy (DY), and 263K TSE strains of transmissible mink encephalopathy yielded similar SDS-PAGE profiles before PK treatment. However, after limited digestion with PK, the PrP-res from the DY strain exhibited a fragmentation pattern that was distinct from that of the other two strains. Infrared spectra of HY and 263K Pr-Pres each had major absorption bands in the amide I region at 1626 and 1636 cm-1 both before and after digestion with PK. These bands were not evident in the DY PrP-res spectra, which had a unique band at 1629-1630 cm-1 and stronger band intensity at both 1616 and 1694-1695 cm-1. Because absorbances from 1616 to 1636 cm-1 of protein infrared spectra are attributed primarily to β-sheet structures, these findings indicate that the conformations of HY and 263K PrP-res differ from DY PrP-res at least in structural regions with β-sheet secondary structure. These results support the hypothesis that strain-specific PrP-res conformers can self-propagate by converting the normal prion protein to the abnormal conformers that induce phenotypically distinct TSE diseases. KW - electrophoresis KW - pathogenesis KW - prions KW - spongiform encephalopathy KW - hamsters KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202865&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Whole body fat oxidation is related to in situ adipose tissue lipolytic response to isoproterenol in males. AU - Snitker, S. AU - Hellmér, J. AU - Boschmann, M. AU - Monroe, M. B. AU - Ravussin, E. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1998/// VL - 275 IS - 3 SP - E400 EP - E404 SN - 0002-9513 AD - Snitker, S.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. N1 - Accession Number: 19981416234. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 299-95-6, 51-30-9, 6700-39-6, 76853-59-2. Subject Subsets: Human Nutrition N2 - To determine whether impaired fat mobilization (lipolysis) may contribute to weight gain, the relation between lipolytic response to nonselective β-adrenergic stimulation and respiratory quotient (RQ) measured in a respiratory chamber was examined in 21 men (11 Caucasians, 10 Pima Indians; 32±5 years, weight 93±24 kg, body fat 30±8%) and 23 women (10 Caucasians, 13 Pima Indians; 32±9 years, weight 95±26 kg, body fat 44±8%). Lipolytic response was assessed as the relative increase in dialysate glycerol concentration (% above baseline) when isoproterenol (1 µmol/litre) was added to the perfusate of a microdialysis probe inserted in the abdominal subcutaneous adipose tissue. In men only, basal RQ measured during sleep from 0500 to 0630 h and adjusted for waist circumference was negatively correlated to lipolytic response (r=-0.66, P=0.001). The results suggest that in men, impaired β-adrenergic-mediated lipolysis may contribute to low rates of fat oxidation, a condition known to predispose to weight gain. KW - adipose tissue KW - beta-adrenergic agonists KW - body fat KW - ethnicity KW - isoprenaline KW - lipid metabolism KW - lipolysis KW - men KW - oxidation KW - respiratory quotient KW - sex differences KW - weight gain KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ethnic differences KW - fat metabolism KW - isoproterenol KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416234&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV vaccines: prospects and challenges. AU - Baltimore, D. AU - Heilman, C. JO - Scientific American JF - Scientific American Y1 - 1998/// VL - 279 IS - 1 SP - 78 EP - 83 SN - 0036-8733 AD - Baltimore, D.: National Institutes of Health AIDS Vaccine Research Committee, USA. N1 - Accession Number: 19982012252. Publication Type: Journal Article. Language: English. KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - research KW - reviews KW - vaccines KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - immunity reactions KW - immunological reactions KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012252&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates. AU - Strickler, H. D. AU - Rosenberg, P. S. AU - Devesa, S. S. AU - Hertel, J. AU - Fraumeni, J. F., Jr. AU - Goedert, J. J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 279 IS - 4 SP - 292 EP - 295 SN - 0098-7484 AD - Strickler, H. D.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19982007930. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health N2 - To determine the risk of ependymoma, osteosarcoma and mesothelioma among individuals in the USA, who as children received SV40 virus-contaminated poliovirus vaccine (used extensively between 1955 and 1963), a retrospective cohort study was conducted using data from the Surveillance, Epidemiology and End Results programme (1973-93), the Connecticut Tumor Registry (1950-69) and national mortality statistics (1947-73). Birth cohorts were grouped for analysis according to those likely to have received SV40-contaminated poliovirus vaccine as infants (born during 1956-62; 60 811 730 person-years of observation), or as children (born during 1947-52; 46 430 953 person-years) and birth cohorts that were unexposed (born during 1964-69; 44 959 979 person-years). Age-specific cancer rates were generally low. Compared with the unexposed, the relative risk (RR) of ependymoma and osteosarcoma was not increased in the cohorts exposed as infants (RR 1.06; 95% confidence interval (CI), 0.69-1.63 and RR 0.87; 95% CI 0.71-1.06, respectively), or as children (RR 0.98; 95% CI 0.57-1.69 and RR 0.85; 95% CI 0.59-1.22, respectively), nor did the exposed have an increased risk of all brain cancers. Mesotheliomas showed a non-significant increase associated with exposure, although the cohorts studied had not yet reached the age at which these tumours tend to occur, resulting in imprecise estimates of risk. KW - adverse effects KW - children KW - contamination KW - infants KW - neoplasms KW - vaccines KW - Connecticut KW - USA KW - man KW - Poliovirus KW - Polyomavirus KW - simian virus 40 KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Enterovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - Polyomavirus KW - simian polyomaviruses KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - cancers KW - human poliovirus KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007930&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Chemokine receptors and genetic variability. Another leap in HIV research. AU - O'Brien, T. R. AU - Goedert, J. J. T2 - JAMA, Journal of the American Medical Association JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 279 IS - 4 SP - 317 EP - 318 SN - 0098-7484 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, US Public Health Service, US Department of Health and Human Services, EPN 434, 6130 Executive Blvd., National Institutes of Health, North Bethesda, MD 20852, USA. N1 - Accession Number: 19982008867. Publication Type: Editorial. Language: English. Number of References: 25 ref. Registry Number: 63231-63-0. N2 - A brief overview is given of advances in HIV-1 and chemokine receptor research, from the discovery of the effect of the chemokines, RANTES, macrophage inflammatory protein-1 alpha (MIP-1α) and MIP-1β, on macrophage-tropic HIV strains in 1995 to the most recent research on genetic determinants of disease prognosis, such as the effect of CCR5Δ32 deletion reported in the same issue by M. Misrahi et al. (JAMA (1998), 279, 277-280) and also CCR2-64I. It is anticipated that the insights into the role of chemokine receptors in HIV-1 infection will enable new therapeutic approaches. KW - acquired immune deficiency syndrome KW - alleles KW - chemokines KW - children KW - cytokines KW - disease course KW - genetic variation KW - human diseases KW - human immunodeficiency viruses KW - maternal transmission KW - mortality KW - pathogenesis KW - protection KW - receptors KW - research KW - RNA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - death rate KW - disease progression KW - genetic variability KW - genotypic variability KW - genotypic variation KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - ribonucleic acid KW - studies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008867&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment and vaccination strategies to control cholera in sub-Saharan refugee settings. A cost-effectiveness analysis. AU - Naficy, A. AU - Rao, M. R. AU - Paquet, C. AU - Antona, D. AU - Sorkin, A. AU - Clemens, J. D. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 279 IS - 7 SP - 521 EP - 525 SN - 0098-7484 AD - Naficy, A.: National Institute of Child Health and Human Development, Room 7B03, 6100 Executive Blvd., Bethesda, MD 20892, USA. N1 - Accession Number: 19982009970. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Tropical Diseases; Rural Development N2 - A cost-effectiveness analysis was conducted, based on probabilities of cholera outcomes derived from epidemiological data compiled for refugee settings in Malawi during 1987-93; data for costs were obtained from a large relief agency that provides medical care in such settings. The setting was a hypothetical refugee camp with 50 000 persons in sub-Saharan Africa, evaluated for a 2-year period. The costs and outcomes were compared for alternative strategies in which appropriate rehydration therapy for cholera is introduced preemptively (at the establishment of a camp) or reactively (once an epidemic is recognized) and in which mass immunization with oral B subunit killed whole-cell (BS-WC) cholera vaccine is added to a rehydration programme either preemptively or reactively. The main outcome measures were cost per cholera case prevented and cost per cholera death averted. It was calculated that in a situation with no available rehydration therapy suitable for the management of severe cholera, preemptive therapy (US$320 per death averted) costs less and is more effective than reactive therapy (US$586 per death averted). Adding vaccination to preemptive therapy was expensive: US$1745 per additional death averted for preemptive vaccination and US$3833 per additional death averted for reactive vaccination. However, if the cost of vaccine decreases to <US$0.22 per dose, strategies combining vaccination and preemptive therapy become more cost-effective than therapy alone. KW - cholera KW - cost benefit analysis KW - costs KW - disease control KW - human diseases KW - immunization KW - oral rehydration therapy KW - refugees KW - rural development KW - vaccination KW - Africa South of Sahara KW - Malawi KW - man KW - Vibrio cholerae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Africa KW - ACP Countries KW - Anglophone Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - bacterium KW - costings KW - immune sensitization KW - Nyasaland KW - ORT KW - subsaharan Africa KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Other Control Measures (HH700) KW - Demography (UU200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009970&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Trends in HIV incidence among young adults in the United States. AU - Rosenberg, P. S. AU - Biggar, R. J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 279 IS - 23 SP - 1894 EP - 1899 SN - 0098-7484 AD - Rosenberg, P. S.: Biostatistics Branch, National Cancer Institute, 6130 Executive Blvd, EPN/403, Rockville, MD 20892, USA. N1 - Accession Number: 19982013109. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - As of January 1993, about 22 000 men and 11 000 women aged 18 to 22 years were living with HIV infection in the USA. Homosexual contact was the leading route of infection among young men. Heterosexual contact was the leading route of infection among young women. The HIV incidence attributed to homosexual contact or injection drug use decreased among persons aged 20 and 25 years between 1988 and 1993, but HIV incidence attributed to heterosexual contact was stable or increasing. Notably, in men aged 20 and 25 years, HIV prevalence declined by about 50% in white men but was relatively stable in black and Hispanic men. In contrast, HIV prevalence in women aged 20 and 25 years rose by 36% and 45%, respectively, because of increasing heterosexual transmission. Overall, HIV prevalence in persons aged 20 and 25 years declined by only 14% between 1988 and 1993. KW - acquired immune deficiency syndrome KW - adolescents KW - adults KW - children KW - drug abuse KW - drug users KW - epidemiology KW - heterosexual transmission KW - heterosexuality KW - Hispanics KW - HIV infections KW - homosexuality KW - human diseases KW - human immunodeficiency viruses KW - incidence KW - injecting drug users KW - men KW - minorities KW - transmission KW - trends KW - women KW - youth KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - drug abusers KW - drug use KW - heterosexuals KW - homosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - teenagers KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Social Structure (UU480) (Discontinued March 2000) KW - Women (UU500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013109&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. AU - Winkler, C. AU - Modi, W. AU - Smith, M. W. AU - Nelson, G. W. AU - Wu XueYun AU - Carrington, M. AU - Dean, M. AU - Honjo, T. AU - Tashiro, K. AU - Yabe, D. AU - Buchbinder, S. AU - Vittinghoff, E. AU - Goedert, J. J. AU - O'Brien, T. R. AU - Jacobson, L. P. AU - Detels, R. AU - Donfield, S. AU - Willoughby, A. AU - Gomperts, E. AU - Vlahov, D. AU - Phair, J. AU - O'Brien, S. J. JO - Science (Washington) JF - Science (Washington) Y1 - 1998/// VL - 279 IS - 5349 SP - 389 EP - 393 SN - 0036-8075 AD - Winkler, C.: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. N1 - Accession Number: 19982002981. Publication Type: Journal Article. Corporate Author: ALIVE Study; Multicenter AIDS Cohort Study; Multicenter Hemophilia Cohort Study; San Francisco City Cohort Language: English. Number of References: 47 ref. N2 - Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic HIV-1. A common polymorphism, SDF1-3′A, was identified in an evolutionarily conserved segment of the 3′ untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3′A/3′A delays the onset of AIDS, according to a genetic association analysis of 2857 patients enrolled in 5 AIDS cohort studies. The recessive protective effect of SDF1-3′A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS. KW - acquired immune deficiency syndrome KW - CD4 antigens KW - chemokines KW - cytokines KW - disease course KW - effects KW - genes KW - genetic variation KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infection KW - lymphocytes KW - mutations KW - pathogenesis KW - patients KW - protection KW - receptors KW - strains KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - CD4 KW - disease progression KW - genetic variability KW - genotypic variability KW - genotypic variation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002981&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. AU - Schrager, L. K. AU - D'Souza, M. P. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 280 IS - 1 SP - 67 EP - 71 SN - 0098-7484 AD - Schrager, L. K.: Epidemiology Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Solar Bldg 2C10, Bethesda, MD 20892, USA. N1 - Accession Number: 19982011437. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - The eradication of HIV-1 from infected persons is the ultimate goal of HIV therapeutic interventions. Great strides have been made in developing potent antiretroviral regimens that greatly suppress HIV-1 replication. Despite these therapeutic advances, major obstacles remain to eradicating HIV-1. Reservoirs of HIV-1 have been identified that represent major impediments to eradication. Conceptually, there are 2 types of sanctuaries for HIV-1, cellular and anatomical. Cellular sanctuaries may include latent CD4+ T cells containing integrated HIV-1 provirus; macrophages, which may express HIV-1 for prolonged periods; and follicular dendritic cells, which may hold infectious HIV-1 on their surfaces for indeterminate lengths of time. The key anatomical reservoir for HIV-1 appears to be the central nervous system. An understanding of the nature of HIV within these reservoirs is critical to devising strategies to hasten viral eradication. KW - antiviral agents KW - central nervous system KW - combination therapy KW - disease control KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - latent infections KW - leukocytes KW - macrophages KW - reviews KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - CNS KW - combined modality therapy KW - follicular dendritic cells KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - leucocytes KW - multimodal treatment KW - T cells KW - white blood cells KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011437&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The National Cholesterol Education Program. Progress and prospects. AU - Cleeman, J. I. AU - Lenfant, C. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1998/// VL - 280 IS - 24 SP - 2099 EP - 2104 SN - 0098-7484 AD - Cleeman, J. I.: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, 31 Center Dr, Bldg 31, Room 4A16, Bethesda, MD 20892-2480, USA. N1 - Accession Number: 19991401792. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition N2 - The review looks at The National Cholesterol Education Programme (NCEP) and the role it has played over the last 50 years. Since 1985, the NCEP has adhered to 2 principles: mounting educational campaigns for professionals and the public; building on a strong science base and working in partnership with other organizations. Progress has been made in reducing blood cholesterol and increasing cholesterol awareness. The impact of cholesterol education is clearly visible in 4 major trends: increasing professional and public cholesterol awareness; declining dietary intakes of saturated fat, total fat, and cholesterol; falling serum cholesterol levels; and a continuing decline in coronary heart disease (CHD) mortality rates. Nevertheless, cholesterol levels are still being undertreated, especially in patients with CHD, and substantial scientific and educational challenges remain. As the NCEP looks forward to the 21st century, they plan to make continued progress by using emerging scientific developments and pursuing the powerful combination of cholesterol lowering in CHD patients and in primary prevention. KW - atherosclerosis KW - blood KW - cardiovascular diseases KW - cholesterol KW - diet KW - fats KW - heart diseases KW - nutrition education KW - nutrition programmes KW - prevention KW - reviews KW - saturated fats KW - serum KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - arteriosclerosis KW - coronary diseases KW - feeding programmes KW - feeding programs KW - food programs KW - nutrition programs KW - United States of America KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991401792&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The NIMH Multisite HIV Prevention Trial: reducing HIV sexual risk behaviour. JO - Science (Washington) JF - Science (Washington) Y1 - 1998/// VL - 280 IS - 5371 SP - 1889 EP - 1894 SN - 0036-8075 AD - Multisite Staff Collaborator, National Institute of Mental Health, NIH, Parklawn Bldg., Rm 18-101, 5600 Fishers Lane, Rockville, MD 20897, USA. N1 - Accession Number: 19982009762. Publication Type: Journal Article. Corporate Author: USA, National Institute of Mental Health (NIMH) Multisite HIV Prevention Group Language: English. Number of References: 17 ref. N2 - The efficacy of a behavioural intervention to reduce HIV risk behaviours was tested in a randomized, controlled trial with 3 high-risk populations at 37 clinics from 7 sites across the USA. Compared with the 1855 individuals in the control condition, the 1851 participants assigned to a small-group, 7-session HIV risk reduction programme reported fewer unprotected sexual acts, had higher levels of condom use, and were more likely to use condoms consistently over a 12-month follow-up period. On the basis of clinical record review, no difference in overall STD reinfection rate was found between intervention and control condition participants. However, among men recruited from STD clinics, those assigned to the intervention condition had a gonorrhoea incidence rate one half that of those in the control condition. Intervention condition participants also reported fewer STD symptoms over the 12-month follow-up period. Study outcomes suggest that behavioural interventions can reduce HIV-related sexual risk behaviour among low-income women and men served in public health settings. Studies that test strategies for reducing sexual risk behaviour over longer periods of time are needed, especially with populations that remain most vulnerable to HIV infection. KW - acquired immune deficiency syndrome KW - disease prevention KW - human diseases KW - human immunodeficiency viruses KW - intervention KW - public health KW - risk reduction KW - sexual behaviour KW - sexually transmitted diseases KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - human immunodeficiency virus KW - sexual behavior KW - sexual practices KW - sexuality KW - sexually transmitted infections KW - STDs KW - United States of America KW - venereal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009762&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Bloodstream- versus tick-associated variants of a relapsing fever bacterium. AU - Schwan, T. G. AU - Hinnebusch, B. J. JO - Science (Washington) JF - Science (Washington) Y1 - 1998/// VL - 280 IS - 5371 SP - 1938 EP - 1940 SN - 0036-8075 AD - Schwan, T. G.: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19980506475. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The relapsing fever spirochaete Borrelia hermsii alternates infections between a mammal and a tick vector. Whether the spirochaete changes phenotypically in the different hosts was examined by allowing the tick Ornithodoros hermsi to feed on mice infected with serotype 7 or serotype 8 of B. hermsii. Upon infection of ticks, the spirochaetal serotype-specific variable major proteins (Vmps) 7 and 8 became undetectable and were replaced by Vmp33. This switch from a bloodstream- to tick-associated phenotype could be induced in culture by a decrease in temperature. After tick-bite transmission back to mice, the process was reversed and the spirochaetes resumed expression of the same Vmp present in the previous infectious blood meal. KW - disease vectors KW - ectoparasites KW - infections KW - laboratory animals KW - phenotypes KW - proteins KW - relapsing fever KW - temperature KW - tickborne relapsing fever KW - Acari KW - Arachnida KW - Borrelia hermsii KW - mice KW - Ornithodoros KW - Ornithodoros hermsi KW - spirochaetes KW - Arachnida KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Argasidae KW - Metastigmata KW - Acari KW - Ornithodoros KW - bacterium KW - variable major proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506475&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic acceleration of AIDS progression by a promoter variant of CCR5. AU - Martin, M. P. AU - Dean, M. AU - Smith, M. W. AU - Winkler, C. AU - Gerrard, B. AU - Michael, N. L. AU - Lee, B. AU - Doms, R. W. AU - Margolick, J. AU - Buchbinder, S. AU - Goedert, J. J. AU - O'Brien, T. R. AU - Hilgartner, M. W. AU - Vlahov, D. AU - O'Brien, S. J. AU - Carrington, M. JO - Science (Washington) JF - Science (Washington) Y1 - 1998/// VL - 282 IS - 5395 SP - 1907 EP - 1911 SN - 0036-8075 AD - Martin, M. P.: Science Applications International Corporation (SAIC), National Cancer Institute, Frederick, MD 21702, USA. N1 - Accession Number: 19992001155. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Public Health N2 - Genetic association analysis of 5 cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infected individuals homozygous for a multisite haplotype of the CCR5 regulatory region containing the promoter allele, CCR5P1, progress to AIDS more rapidly than those with other CCR5 promoter genotypes, particularly in the early years after infection. Composite genetic epidemiological analyses of genotypes bearing CCR5P1, CCR5-Δ32, CCR2-641 and SDF1-3′A affirmed distinct regulatory influences for each gene on AIDS progression. It is estimated that 10-17% of patients who develop AIDS within 3.5 years of human immunodeficiency virus type 1 (HIV-1) infection do so because they are homozygous for CCR5P1/P1, and that 7-13% of all people carry this susceptible genotype. It is concluded that the cumulative and interactive influence of these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease progression. KW - acquired immune deficiency syndrome KW - alleles KW - disease course KW - epidemiology KW - genes KW - genotypes KW - homozygosity KW - human diseases KW - molecular genetics KW - pathogenesis KW - promoters KW - receptors KW - viral diseases KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - biochemical genetics KW - disease progression KW - human immunodeficiency virus type 1 KW - promoter region KW - promoter sequences KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001155&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - "A calculated risk": the Salk polio vaccine field trials of 1954. AU - Meldrum, M. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1998/// VL - 317 IS - 7167 SP - 1233 EP - 1236 SN - 0959-8138 AD - Meldrum, M.: National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992000396. Publication Type: Journal Article. Language: English. Number of References: 21 ref. KW - clinical trials KW - history KW - human diseases KW - immunization KW - inactivated vaccines KW - poliomyelitis KW - vaccination KW - vaccines KW - viral diseases KW - USA KW - man KW - Poliovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Enterovirus KW - Picornaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human poliovirus KW - immune sensitization KW - killed vaccines KW - polio KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 1755 and all that: a historical primer of transmissible spongiform encephalopathy. AU - Brown, P. AU - Bradley, R. JO - British Medical Journal (Clinical Research edition) JF - British Medical Journal (Clinical Research edition) Y1 - 1998/// VL - 317 IS - 7174 SP - 1688 EP - 1692 SN - 0959-8138 AD - Brown, P.: Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, Building 36, Room 5B20, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992201500. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Veterinary Science N2 - A review of the history of prion diseases beginning with the first recorded mention of scrapie in sheep in 1755. KW - bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - prion diseases KW - prions KW - scrapie KW - veterinary history KW - UK KW - cattle KW - man KW - sheep KW - Bos KW - Bovidae KW - ruminants KW - Artiodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Ovis KW - British Isles KW - Western Europe KW - Europe KW - Commonwealth of Nations KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - bovine encephalopathy KW - Britain KW - BSE KW - mad cow disease KW - United Kingdom KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992201500&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. AU - Vinetz, J. M. AU - Li Jun AU - McCutchan, T. F. AU - Kaslow, D. C. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1998/// VL - 338 IS - 6 SP - 367 EP - 371 SN - 0028-4793 AD - Vinetz, J. M.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 19980802478. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 59-05-2. Subject Subsets: Protozoology; Public Health; Tropical Diseases N2 - The case is reported of a 74-year-old Greek woman from the island of Karpathos who was found to have splenomegaly during a routine examination. The woman was asymptomatic and had never travelled outside Greece. Symptoms of malaria began after she was treated with methotrexate for lymphoma. Although blood smears were repeatedly negative, Plasmodium malariae infection was diagnosed by a polymerase chain reaction assay. Malaria had been eradicated in Greece by about 1950 and it was concluded that the patient had been infected for at least 40 and possibly as long as 70 years. The disease had remained latent until the patient was treated with an immunosuppressive agent. KW - antineoplastic agents KW - asymptomatic infections KW - case reports KW - diagnosis KW - human diseases KW - immunosuppressive agents KW - infections KW - latent infections KW - malaria KW - methotrexate KW - parasites KW - polymerase chain reaction KW - spleen KW - splenomegaly KW - Greece KW - man KW - Plasmodium malariae KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - Balkans KW - Southern Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - amethopterin KW - cytotoxic agents KW - immunosuppressants KW - PCR KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission of multidrug-resistant human immunodeficiency virus-the wake-up call. AU - Cohen, O. J. AU - Fauci, A. S. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1998/// VL - 339 IS - 5 SP - 341 EP - 343 SN - 0028-4793 AD - Cohen, O. J.: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-2520, USA. N1 - Accession Number: 19982011001. Publication Type: Journal Article. Language: English. Number of References: 15 ref. N2 - The availability of potent antiretroviral drugs capable of long-term suppression of HIV replication is a welcome advance that has rapidly improved the prognosis for HIV-infected persons; however, it must be anticipated that in all but exceptional cases, the virus will have sufficient genetic plasticity to develop drug resistance during periods of subtotal suppression of replication. Transmission of multidrug-resistant HIV will most likely occur with increasing frequency, and the wake-up call provided by the report of Hecht et al. (New Engl. Jour. Med. (1998) 339 307-311) should reinforce the lessons taught by the tubercle bacillus, Staphylococcus aureus, and Streptococcus pneumoniae. Appropriate prescription of potent antiretroviral regimens, maximal adherence to the regimen, the development of new drugs directed against different stages of the viral-replication cycle, and the creation of accurate and reliable assays to assess drug resistance are all essential for the successful long-term control of HIV replication. KW - antiviral agents KW - drug resistance KW - drug therapy KW - human diseases KW - human immunodeficiency viruses KW - multiple drug resistance KW - replication KW - transmission KW - viral replication KW - man KW - Staphylococcus KW - Staphylococcus aureus KW - Streptococcus KW - Streptococcus pneumoniae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Staphylococcaceae KW - Bacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Staphylococcus KW - Streptococcaceae KW - Lactobacillales KW - Streptococcus KW - Bacillus KW - bacterium KW - chemotherapy KW - human immunodeficiency virus KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011001&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Poxvirus dilemmas - monkeypox, smallpox, and biologic terrorism. AU - Breman, J. G. AU - Henderson, D. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1998/// VL - 339 IS - 8 SP - 556 EP - 559 SN - 0028-4793 AD - Breman, J. G.: National Institutes of Health, Bethesda, MD 20892-2220, USA. N1 - Accession Number: 19982013157. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Tropical Diseases N2 - This paper discusses whether recent outbreaks of human monkeypox in the Democratic Republic of the Congo (Zaire) could represent the return of another form of smallpox. Potential use of variola virus as a biological weapon in terrorism is considered together with the implications of the WHO decision to advise destruction of all isolates of the variola virus in June 1999. KW - biological warfare KW - epidemiology KW - human diseases KW - monkeypox KW - smallpox KW - terrorism KW - viral diseases KW - Congo Democratic Republic KW - man KW - monkeypox virus KW - variola virus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthopoxvirus KW - Chordopoxvirinae KW - Poxviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Francophone Africa KW - Least Developed Countries KW - Developing Countries KW - viral infections KW - Zaire KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013157&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Visceral abdominal-fat accumulation associated with use of indinavir. AU - Miller, K. D. AU - Jones, E. AU - Yanovski, J. A. AU - Shankar, R. AU - Feuerstein, I. AU - Falloon, J. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1998/// VL - 351 IS - 9106 SP - 871 EP - 875 SN - 0140-6736 AD - Miller, K. D.: National Institutes of Health (Bldg 10, Rm 8C410), Bethesda, MD 20892, USA. N1 - Accession Number: 19982005590. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 150378-17-9. Subject Subsets: Human Nutrition N2 - The results of this study suggest that some HIV-1-infected patients on indinavir treatment accumulate intraabdominal fat that may cause abdominal symptoms. Recent evidence suggests that other HIV-1 protease inhibitors may be associated with changes in body-fat distribution. Larger studies of protease-inhibitor treatment are needed to investigate this association further and to investigate metabolic or endocrine mechanisms that may underlie this phenomenon. (However, see Lo et al.Lancet (1998) 351 867-870.) KW - abdomen KW - adverse effects KW - antiviral agents KW - body fat KW - human diseases KW - indinavir KW - proteinase inhibitors KW - symptoms KW - treatment KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adverse reactions KW - human immunodeficiency virus type 1 KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005590&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene. AU - Mei Qin AU - Gurunathan, S. AU - Masur, H. AU - Kovacs, J. A. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1998/// VL - 351 IS - 9116 SP - 1631 EP - 1632 SN - 0140-6736 AD - Mei Qin: Critical Care Medicine Department, Clinical Center and Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, MD 20892-1662, USA. N1 - Accession Number: 19981201922. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 8064-90-2. Subject Subsets: Medical & Veterinary Mycology N2 - Cases are reported in 31- and 39-year-old HIV-positive men from the USA [dates not given] with P. carinii pneumonia, in whom prophylaxis or treatment with trimethoprim-sulfamethoxazole was unsuccessful. Mutations in the dihydropteroate synthase genes were identified in both patients. KW - acquired immune deficiency syndrome KW - antifungal agents KW - case reports KW - co-trimoxazole KW - drug resistance KW - drug therapy KW - genes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - lungs KW - men KW - mutations KW - mycoses KW - opportunistic infections KW - pneumocystosis KW - pneumonia KW - treatment KW - USA KW - fungi KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - chemotherapy KW - dihydropteroate synthase KW - fungistats KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201922&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - A new classification for HIV-1. AU - Berger, E. A. AU - Doms, R. W. AU - Fenyö, E. M. AU - Korber, B. T. M. AU - Littman, D. R. AU - Moore, J. P. AU - Sattentau, Q. J. AU - Schuitemaker, H. AU - Sodroski, J. AU - Weiss, R. A. T2 - Nature (London) JO - Nature (London) JF - Nature (London) Y1 - 1998/// VL - 391 IS - 6664 SP - 240 EP - 240 SN - 0028-0836 AD - Berger, E. A.: Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bldg 4, Rm 236, Bethesda, MD 20892, USA. N1 - Accession Number: 19982002986. Publication Type: Correspondence. Language: English. Number of References: 10 ref. N2 - It is proposed that isolates that use CCR5 but not CXCR4 be termed R5 viruses, that isolates using CXCR4 but not CCR5 be designated X4 viruses, and isolates able to use both co-receptors with comparable efficiency be called R5X4. Whether an X4 or R5X4 virus is a cell-line-adapted isolate should also be specified. Under this system, R5 viruses are the strains most commonly transmitted sexually, consistent with the high resistance of individuals lacking CCR5 to infection. After about 5 years, in about 50% of patients viruses evolve that are able to use CXCR4, with or without concurrent use of CCR5. These viruses would now be called R5X4 and X4 viruses, respectively. Isolates passaged through a permanent T-cell line should be called T-cell line-adapted (TCLA) X4 or R5X4 viruses, and a similar qualifier can be used for viruses adapted to growth in other cells. A record of co-receptor use by particular HIV-1, HIV-2 and SIV strains will be maintained by the Los Alamos National Laboratory Sequence Database, together with an expanded version of this article. KW - cell lines KW - chemokines KW - classification KW - cytokines KW - human diseases KW - laboratories KW - patients KW - receptors KW - strains KW - T lymphocytes KW - Human immunodeficiency virus 2 KW - simian immunodeficiency virus KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - human immunodeficiency virus type 2 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002986&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antimutagenic and anticarcinogenic potentials of some Thai vegetables. AU - Kusamran, W. R. AU - Tepsuwan, A. AU - Kupradinun, P. JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis Y1 - 1998/// VL - 402 IS - 1/2 SP - 247 EP - 258 SN - 0027-5107 AD - Kusamran, W. R.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand. N1 - Accession Number: 19981417613. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition N2 - 15 commonly consumed Thai vegetables were extracted with hexane, chloroform and methanol, and tested for antimutagenic activities against direct-acting (AF-2 and NaN3) and indirect-acting (AFB1 and B(a)P) mutagens using Ames' mutagenicity test with Salmonella typhimurium TA100 as tester strain. Only the methanol extract of neem (Azadirachta indica) leaves contain weak antimutagen inhibiting the mutagenicities of both direct-acting mutagens. Interestingly, all vegetables studied contained compounds capable of inhibiting the mutagenicity of AFB1, while only some vegetables contain chemical compounds capable of inhibiting B(a)P. Bitter gourd (Momordica charantia), but not sweet basil (Ocimum basilicum), at 6.25 and 12.5% in the diet, partially inhibited DMBA-induced mammary gland carcinogenesis in female Sprague-Dawley rats when fed 2 weeks prior to DMBA. The results demonstrate that Thai vegetables contain antimutagens inhibiting the mutagenicity of some indirect-acting mutagen, particularly AFB1. The mechanism of their antimutagenicity may probably be the inhibition of the activity of metabolic-activating enzymes in the liver. KW - carcinogenesis KW - culinary herbs KW - enzymes KW - extracts KW - inhibition KW - liver KW - mammary gland neoplasms KW - mutagenesis KW - mutagens KW - vegetables KW - Thailand KW - Azadirachta indica KW - Momordica charantia KW - Ocimum basilicum KW - rats KW - Salmonella typhimurium KW - Azadirachta KW - Meliaceae KW - Sapindales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Momordica KW - Cucurbitaceae KW - Violales KW - Ocimum KW - Lamiaceae KW - Lamiales KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - bacterium KW - mammary tumour KW - neem KW - vegetable crops KW - Crop Produce (QQ050) KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417613&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV: from molecular recognition to tissue pathogenesis. AU - Margolis, L. JO - FEBS Letters JF - FEBS Letters Y1 - 1998/// VL - 433 IS - 1/2 SP - 5 EP - 8 SN - 0014-5793 AD - Margolis, L.: Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10D14, Bethesda, MD 20892, USA. N1 - Accession Number: 19982013208. Publication Type: Journal Article. Language: English. Number of References: 52 ref. N2 - Dramatic progress has been made recently in identifying both viral and cellular molecules responsible for binding and fusion of HIV-1 to target cells. In vivo, HIV-1 infection is transmitted by viruses that recognize chemokine receptor CCR5, while viruses isolated at later stages of HIV disease often recognize another chemokine receptor, CXCR4. It is still not understood how this molecular tropism of HIV-1 is translated into the virus' ability to compromise normal cell functions, which results in impairment of lymphoid tissue and causes AIDS. Here, how the new molecular findings might relate to HIV pathogenesis in cells and tissues are discussed. KW - acquired immune deficiency syndrome KW - binding sites KW - chemokines KW - human diseases KW - human immunodeficiency viruses KW - pathogenesis KW - receptors KW - reviews KW - viral diseases KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - binding site KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013208&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - First National AIDS Malignancy Conference. AU - Feigal, E.\Beral, V.\Kieff, E.\Palefsky, J. M.\Marco, M.\Rabkin, C. S.\Lowy, D. R.\Mueller, B. U.\Levine, A. M.\Maiman, M.\Weiss, R. A.\Gallo, R. C.\Krown, S. E.\Moore, P. S.\Neipel, F.\Nicholas, J.\Rooney, C. M.\Gaidano, G.\Kaplan, L. D. T2 - Journal of the National Cancer Institute Monographs JO - Journal of the National Cancer Institute Monographs JF - Journal of the National Cancer Institute Monographs Y1 - 1998/// IS - 23 SP - 105 + iv EP - 105 + iv AD - USA, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19982007903. Publication Type: Conference proceedings. Language: English. N2 - This issue is devoted to the proceedings of a conference held at the National Institutes of Health, Bethesda, Maryland, USA, 28-30 April, 1997. Contributions by many authors cover epidemiology of immunodeficiency-associated cancers; molecular pathogenesis of virus-induced cancers in HIV infection and AIDS; human papillomavirus infection and anogenital neoplasia in HIV disease; the community perspective of AIDS-related cancers; association of non-AIDS defining cancers with HIV infection; papillomaviruses and cervical cancer: pathogenesis and vaccine development; cancers in HIV-infected children; Hodgkin's disease in HIV infection; management of cervical neoplasia in HIV-infected women; Kaposi's sarcoma: association with humanherpesvirus 8, pathogenesis, therapeutics, KS-associated oncogenes and oncogenesis; immunotherapy for Epstein-Barr virus-associated cancers; genetic basis of AIDS-related lymphomagenesis; and clinical management of HIV-associated non-Hodgkin's lymphoma. KW - acquired immune deficiency syndrome KW - children KW - epidemiology KW - human diseases KW - Kaposi's sarcoma KW - lymphoma KW - malignant course KW - neoplasms KW - pathogenesis KW - treatment KW - Herpesviridae KW - Human herpesvirus 4 KW - human herpesvirus 8 KW - human papillomaviruses KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - Rhadinovirus KW - Papillomavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - Papillomaviridae KW - AIDS KW - cancers KW - Epstein-Barr virus KW - human papillomavirus KW - Kaposi's sarcoma-associated herpesvirus KW - Papovaviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007903&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The role of free radical mediation of protein oxidation in aging and disease. AU - Stadtman, E. R. A2 - Özben, T. T2 - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997. JO - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997. JF - Free radicals, oxidative stress, and antioxidants: pathological and physiological significance. Proceedings of a NATO Advanced Study Institute, Antalya, Turkey, 24 May-4 June, 1997. Y1 - 1998/// SP - 131 EP - 143 CY - New York; USA PB - Plenum Publishing Corporation SN - 0306458136 AD - Stadtman, E. R.: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Room 222, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991416045. Publication Type: Conference paper. Language: English. Number of References: 5 pp of ref. Subject Subsets: Human Nutrition N2 - A review. KW - aging KW - diseases KW - free radicals KW - oxidation KW - protein KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991416045&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Docosahexaenoic acid-containing phospholipids optimally promote rhodopsin activation. AU - Mitchell, D. C. AU - Litman, B. J. A2 - Riemersma, R. A. A2 - Armstrong, R. A2 - Kelly, R. W. A2 - Wilson, R. T2 - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. JO - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. JF - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. Y1 - 1998/// SP - 154 EP - 158 CY - Champaign; USA PB - AOCS Press SN - 0935315969 AD - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA. N1 - Accession Number: 19991403965. Publication Type: Conference paper. Language: English. Number of References: 19 ref. Registry Number: 25167-62-8, 9009-81-8. Subject Subsets: Human Nutrition KW - docosahexaenoic acid KW - essential fatty acids KW - phospholipids KW - polyenoic fatty acids KW - rhodopsin KW - visual pigments KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - polyunsaturated fatty acids KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403965&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Alcoholism, antioxidant status, and essential fatty acids. AU - Lands, W. E. M. AU - Pawlosky, R. J. A2 - Papas, A. M. T2 - Antioxidant status, diet, nutrition, and health. JO - Antioxidant status, diet, nutrition, and health. JF - Antioxidant status, diet, nutrition, and health. Y1 - 1998/// SP - 299 EP - 344 CY - Bethesda; USA PB - American Fisheries Society SN - 184938009X AD - Lands, W. E. M.: NIAAA, National Institutes of Health, 6000 Executive Blvd., Wilco Building, Room 400, Bethesda, MD 20892-7003, USA. N1 - Accession Number: 19991403637. Publication Type: Miscellaneous. Language: English. Number of References: 303 ref. Registry Number: 64-17-5, 70-18-8, 68-26-8, 7782-49-2, 1406-18-4. Subject Subsets: Human Nutrition N2 - This chapter describes the effects of alcohol abuse on cellular antioxidant status and on the essential fatty acids and nutrients that antioxidants help to preserve. KW - alcoholism KW - enzymes KW - ethanol KW - glutathione KW - lipid peroxidation KW - lipids KW - minerals KW - nutritional state KW - polyenoic fatty acids KW - retinol KW - selenium KW - trace elements KW - vitamin E KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - ethyl alcohol KW - lipins KW - microelements KW - nutritional status KW - polyunsaturated fatty acids KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403637&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - The phospholipid bilayer mediates the effect of primary alcohols on rhodopsin activation. AU - Mitchell, D. C. AU - Litman, B. J. A2 - Riemersma, R. A. A2 - Armstrong, R. A2 - Kelly, R. W. A2 - Wilson, R. T2 - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. JO - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. JF - Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress, Edinburgh, Scotland, UK, July 20-24, 1997. Y1 - 1998/// SP - 336 EP - 340 CY - Champaign; USA PB - AOCS Press SN - 0935315969 AD - Mitchell, D. C.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA. N1 - Accession Number: 19991404047. Publication Type: Conference paper. Language: English. Number of References: 29 ref. Registry Number: 64-17-5, 9009-81-8. Subject Subsets: Human Nutrition KW - alcoholic beverages KW - alcoholism KW - alcohols KW - cell cultures KW - ethanol KW - membranes KW - phospholipids KW - rhodopsin KW - ethyl alcohol KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404047&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antioxidants and cancer: evidence from human studies and intervention trials. AU - Albanes, D. AU - Hartman, T. J. A2 - Papas, A. M. T2 - Antioxidant status, diet, nutrition, and health. Y1 - 1998/// CY - Bethesda; USA PB - American Fisheries Society SN - 184938009X AD - Albanes, D.: Division of Clinical Sciences, National Cancer Institute, 6006 Executive Blvd., Room 321, National Institutes of Health, Bethesda, MD 20892-7058, USA. N1 - Accession Number: 19991403629. Publication Type: Book chapter. Language: English. Number of References: 385 ref. Registry Number: 50-81-7, 7235-40-7, 7439-98-7, 7782-49-2, 1406-18-4. Subject Subsets: Human Nutrition N2 - The relationship between cancer and antioxidants is explored under the following headings: Antioxidants and carcinogenesis; β-Carotene and other carotenoids-observational epidemiological studies, randomized intervention trials; Vitamin C; Vitamin E; Selenium. KW - antioxidants KW - ascorbic acid KW - beta-carotene KW - carotenoids KW - diet KW - minerals KW - molybdenum KW - neoplasms KW - selenium KW - vitamin E KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - Mo KW - tetraterpenoids KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403629&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Vitamin C. AU - Rumsey, S. C. AU - Wang, Y. AU - Levine, M. A2 - Papas, A. M. T2 - Antioxidant status, diet, nutrition, and health. Y1 - 1998/// CY - Bethesda; USA PB - American Fisheries Society SN - 184938009X AD - Rumsey, S. C.: Laboratory of Cell Biology and Kinetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20852, USA. N1 - Accession Number: 19991403616. Publication Type: Book chapter. Language: English. Number of References: 160 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - This chapter provides an overview of the current data concerning vitamin C. Areas of focus include: Biochemistry-chemical reactions, enzymatic reactions; pharmacokinetics-intake and bioavailability, plasma concentrations, cellular distribution; and In situ kinetics and recommended intake. KW - ascorbic acid KW - availability KW - blood KW - enzymes KW - guidelines KW - intake KW - kinetics KW - vitamins KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - recommendations KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403616&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Diagnosis of invasive fungal infections in transplant recipients. AU - Walsh, T. J. AU - Chanock, S. J. A2 - Bowden, R. A. A2 - Ljungman, P. A2 - Paya, C. V. T2 - Transplant infections. Y1 - 1998/// CY - Hagerstown; USA PB - Lippincott-Raven Publishers SN - 0397587767 AD - Walsh, T. J.: Infectious Disease Section, Pediatric Branch, National Cancer Institute, Bethesda, MD 90892, USA. N1 - Accession Number: 19991201745. Publication Type: Book chapter. Language: English. Number of References: 259 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The diagnosis of invasive infections due to yeasts and filamentous fungi in transplant recipients is reviewed. The clinical manifestations of candidosis and aspergillosis, direct examination and culture of Candida spp. and Aspergillus spp., the significance and detection of fungaemia, serological methods to detect candidosis and aspergillosis, amplification of Candida and Aspergillus DNA by polymerase chain reaction, and antifungal susceptibility testing of yeasts, are discussed. Infections due to Cryptococcus neoformans, Trichosporon, Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis and Penicillium marneffei, Fusarium, Pseudallescheria boydii and agents of zygomycosis, are also considered. KW - aspergillosis KW - blastomycosis KW - candidosis KW - coccidioidomycosis KW - cryptococcosis KW - diagnosis KW - fusariosis KW - histoplasmosis KW - human diseases KW - immunocompromised hosts KW - infections KW - opportunistic infections KW - reviews KW - transplant recipients KW - transplantation KW - zygomycosis KW - Aspergillus KW - Blastomyces dermatitidis KW - Candida KW - Coccidioides immitis KW - Cryptococcus neoformans KW - Fusarium KW - Histoplasma capsulatum KW - man KW - Penicillium marneffei KW - Pseudallescheria boydii KW - Trichosporon KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Blastomyces KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Histoplasma KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Penicillium KW - Pseudallescheria KW - Microascaceae KW - Microascales KW - Trichosporonaceae KW - Ajellomyces capsulatus KW - candidiasis KW - coccidiomycosis KW - european blastomycosis KW - fungus KW - fusarioses KW - Hyphomycetes KW - phycomycosis KW - recipients KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201745&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology. AU - Wynn, T. A. JO - Microbes and Infection JF - Microbes and Infection Y1 - 1999/// VL - 1 IS - 7 SP - 525 EP - 534 AD - Wynn, T. A.: The Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990805771. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Registry Number: 130068-27-8, 207137-56-2, 148157-34-0. Subject Subsets: Helminthology N2 - This review covers: the pulmonary granuloma model (evidence of a primary role for Th2-associated cytokines in egg-induced granuloma formation); IL-4 and IL-10 are both essential to the development of a polarized egg-specific Th2-type cytokine response; pulmonary egg-induced granuloma formation is mediated by the dual effects of IL-4 and IL-13; characterization of an IL-12-based vaccination strategy that reduces egg-induced pathology and Th2-type cytokine expression; the irradiated cercariae model (characterization of the resistance mechanisms in singly and multiply immunized mice); evidence of a mixed Th1/Th2-type response in the lungs and lymph nodes of vaccinated and challenged mice; IL-12 enhances immunity induced by the irradiated cercariae vaccine by boosting type-1-associated humoral and cell-mediated immune responses. KW - cytokines KW - helminths KW - immune response KW - immunization KW - immunopathology KW - interleukin 10 KW - interleukin 12 KW - interleukin 13 KW - interleukin 4 KW - parasites KW - reviews KW - schistosomiasis KW - T lymphocytes KW - vaccines KW - Schistosoma mansoni KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - animals KW - eukaryotes KW - bilharzia KW - bilharziasis KW - granulomata KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - schistosomosis KW - Strigeida KW - T cells KW - T helper cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805771&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relative validity of a food frequency questionnaire among tin miners in China: 1992/93 and 1995/96 diet validation studies. AU - Forman, M. R. AU - Zhang, J. AU - Nebeling, L. AU - Yao, S. X. AU - Slesinski, M. J. AU - Qiao, Y. L. AU - Ross, S. AU - Keith, S. AU - Maher, M. AU - Giffin, C. AU - Barrett, M. AU - Taylor, P. R. AU - Graubard, B. I. JO - Public Health Nutrition JF - Public Health Nutrition Y1 - 1999/// VL - 2 IS - 3 SP - 301 EP - 315 AD - Forman, M. R.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-7326, USA. N1 - Accession Number: 19991414296. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - Diet validation research was conducted to compare reporting of dietary intake in a food frequency questionnaire (FFQ) with intake reported in food recalls. Because the population received annual salary increments that could modify food intake, diet validation studies (DVS) were conducted during 2 time intervals. A 99-item FFQ was administered by an interviewer twice in 1-year, and responses to each FFQ item were compared with 28 days of interviewer-administered food recalls that were collected in four 1-week intervals during each season of 1992/93. The second validation study in 1995/96 had a similar design. Among a cohort of high risk tin miners for lung cancer, 2 different samples (n=141 in 1992/93, and n=113 in 1995/96) for each DVS were randomly selected from 4 representative mine units. Miners reported a significantly higher average frequency of intake of foods in the food recalls than the FFQ. Deattenuated Pearson correlation coefficients of the frequency of food intake between the FFQ and food recalls were in the range of -0.40 to 0.72 in both studies, with higher positive correlations for beverages and cereal staples than for animal protein sources, vegetables, fruits and legumes. The percentage of individuals with exact agreement in the extreme quartiles of intake in the food recalls and FFQ ranged from 0 to 100%. Among Chinese miners, the range in correlations between the food recalls and the FFQ were due to; market availability of foods during the food recall weeks compared to their annual reported intake in the FFQ, cultural perception of time and differences in how the intake of mixed dishes and their multi-ingredient foods were reported in the recalls vs. the FFQ. The range in the percentage of agreement in the same quartiles and the changes in food intake over time may have implications for the analysis of the diet-disease relationship in this cohort. KW - diet studies KW - diet study techniques KW - food intake KW - intake KW - legumes KW - lung cancer KW - lungs KW - neoplasms KW - protein sources KW - questionnaires KW - risk factors KW - vegetables KW - China KW - Fabaceae KW - man KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - People's Republic of China KW - vegetable crops KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414296&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genome projects, genetic analysis, and the changing landscape of malaria research. AU - Wellems, T. E. AU - Su XinZhuan AU - Ferdig, M. AU - Fidock, D. A. A2 - Cormack, B. A2 - Rouse, B. T. A2 - Beverley, S. M. JO - Current Opinion in Microbiology JF - Current Opinion in Microbiology Y1 - 1999/// VL - 2 IS - 4 SP - 415 EP - 419 AD - Wellems, T. E.: Malaria Genetics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 4 Center Drive, MSC 0425, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000805451. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Protozoology N2 - This review discusses recent research on the molecular genetics of Plasmodium falciparum. The main sections cover: genetic analysis and linkage maps; chromosome maps and sequencing projects; the use of the large amounts of data now available to achieve advances against the disease; and Internet resources and information exchange. It is concluded that deciphering the P. falciparum genome will require understanding at multiple levels of an integrated system, and will transform malaria research in unexpected ways. KW - diffusion of information KW - DNA sequencing KW - genetic analysis KW - genome analysis KW - human diseases KW - internet KW - malaria KW - molecular genetics KW - parasites KW - research KW - reviews KW - man KW - Plasmodium falciparum KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - biochemical genetics KW - information dissemination KW - nucleotide sequence analysis KW - nucleotide sequencing KW - studies KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) KW - Information and Documentation (CC300) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000805451&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses. AU - McDowell, M. A. AU - Sacks, D. L. A2 - Cormack, B. A2 - Rouse, B. T. A2 - Beverley, S. M. JO - Current Opinion in Microbiology JF - Current Opinion in Microbiology Y1 - 1999/// VL - 2 IS - 4 SP - 438 EP - 443 AD - McDowell, M. A.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. N1 - Accession Number: 20000805547. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Protozoology N2 - This review summarizes findings relevant to the selective impairment of interleukin 12 induction pathways in Leishmania-infected macrophages, in particular the disruption of host cell signal transduction networks. KW - host parasite relationships KW - immune response KW - immunological deficiency KW - interleukin 12 KW - leishmaniasis KW - macrophages KW - parasites KW - reviews KW - signal transduction KW - Leishmania KW - protozoa KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - immune deficiency KW - immunity reactions KW - immunodeficiency KW - immunological reactions KW - leishmaniosis KW - parasite host relationships KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) KW - Human Immunology and Allergology (VV055) (New March 2000) KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000805547&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies. Commentary. AU - Priola, S. A. AU - Caughey, B. AU - Caughey, W. S. JO - Current Opinion in Microbiology JF - Current Opinion in Microbiology Y1 - 1999/// VL - 2 IS - 5 SP - 563 EP - 566 AD - Priola, S. A.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 20002212452. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Veterinary Science KW - bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - porphyrins KW - prion diseases KW - spongiform encephalopathy KW - bovine encephalopathy KW - BSE KW - mad cow disease KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002212452&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Nutritional modulation of aging in nonhuman primates. AU - Lane, M. A. AU - Ingram, D. K. AU - Roth, G. S. JO - Journal of Nutrition, Health & Aging JF - Journal of Nutrition, Health & Aging Y1 - 1999/// VL - 3 IS - 2 SP - 69 EP - 76 AD - Lane, M. A.: Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. N1 - Accession Number: 19991413854. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition N2 - This review summarizes the major findings of studies of energy restriction in primates and its effect on lifespan and the development of age-related diseases. It is concluded that the physiological responses to energy restriction in monkeys parallel the extensive findings reported in rodents. KW - aging KW - energy KW - energy deprivation KW - longevity KW - old age KW - reviews KW - man KW - monkeys KW - Primates KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ageing KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413854&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction. AU - Kari, F. W. AU - Dunn, S. E. AU - French, J. E. AU - Barrett, J. C. JO - Journal of Nutrition, Health & Aging JF - Journal of Nutrition, Health & Aging Y1 - 1999/// VL - 3 IS - 2 SP - 92 EP - 101 AD - Kari, F. W.: Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19991413857. Publication Type: Journal Article. Language: English. Number of References: 95 ref. Registry Number: 61912-98-9. Subject Subsets: Human Nutrition N2 - This paper reviews the role of insulin-like growth factor-1 (IGF-1) and its associated regulatory apparatus as a key endocrine, autocrine and paracrine signalling system involved in mediating the anticarcinogenic activity of dietary restriction. It is concluded that epidemiological observations and clinical oncology results support the involvement of IGF-1 in carcinogenesis and anticarcinogenesis, leading to the hypothesis that factors such as IGF-1 which regulate body size and composition may be related to cancer incidence or prognosis in man. KW - carcinogenesis KW - energy deprivation KW - insulin-like growth factor KW - neoplasms KW - reviews KW - cancers KW - somatomedin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic strategies to inhibit HIV. AU - Morgan, R. A. JO - Molecular Medicine Today JF - Molecular Medicine Today Y1 - 1999/// VL - 5 IS - 10 SP - 454 EP - 458 AD - Morgan, R. A.: Gene Transfer Technology Section, Clinical Gene Therapy Branch/National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1851, USA. N1 - Accession Number: 20002006957. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - The worldwide incidence of HIV infection continues to rise despite more than a decade of intense research aimed at developing effective intervention strategies. Because the mechanisms of action of the essential HIV gene products are now known, these have become potential targets for intervention. Some of these targets are attractive candidates for intervention by gene therapy. This review focuses on the recent progress in gene therapy strategies, including approaches approved for clinical trials. The efficacy of these various anti-HIV strategies, as well as the advantages and drawbacks of the different existing gene delivery systems, is discussed. KW - gene therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Other Control Measures (HH700) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006957&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. AU - Hemmer, B. AU - Gran, B. AU - Zhao YingDong AU - Marques, A. AU - Pascal, J. AU - Tzou, A. AU - Kondo, T. AU - Cortese, I. AU - Bielekova, B. AU - Straus, S. E. AU - McFarland, H. F. AU - Houghten, R. AU - Simon, R. AU - Pinilla, C. AU - Martin, R. JO - Nature Medicine JF - Nature Medicine Y1 - 1999/// VL - 5 IS - 12 SP - 1375 EP - 1382 AD - Hemmer, B.: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5B-16, 10 Center DR MSC 1400, Bethesda, MD 20892-1400, USA. N1 - Accession Number: 20000505586. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A new method of effectively identifying both microbial epitopes and candidate autoantigens in Lyme disease is described. The approach combines data acquisition by positional scanning peptide combinatorial libraries and biometric data analysis by generation of scoring matrices. In a 35-year-old male who presented in 1993 in Wisconsin with chronic neuroborreliosis, this strategy led to the identification of potentially relevant T-cell targets derived from both Borrelia burgdorferi and the host. The antigen specificity of a single T-cell clone could be degenerate and yet the clone could preferentially recognize different peptides derived from the same organism, thus demonstrating that flexibility in T-cell recognition does not preclude specificity. KW - amino acid sequences KW - antigens KW - autoimmunity KW - clones KW - epitopes KW - human diseases KW - Lyme disease KW - molecular genetics KW - peptides KW - T lymphocytes KW - USA KW - Wisconsin KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - East North Central States of USA KW - North Central States of USA KW - USA KW - Lake States of USA KW - antigenic determinants KW - antigenicity KW - bacterium KW - biochemical genetics KW - immunogens KW - lyme borreliosis KW - protein sequences KW - T cells KW - United States of America KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000505586&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Development and testing of Streptococcus pneumoniae conjugate vaccines. AU - Klein, D. L. AU - Eskola, J. A2 - Tomasz, A. A2 - Carbon, C. JO - Clinical Microbiology and Infection JF - Clinical Microbiology and Infection Y1 - 1999/// VL - 5 IS - Suppl. 4 SP - 4S17 EP - 4S28 AD - Klein, D. L.: National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. N1 - Accession Number: 20002004541. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Subject Subsets: Public Health N2 - This paper on pneumococcal conjugate vaccines reviews clinical data that have contributed to the characterization of conjugate vaccines, recent vaccine trials that define efficacy, and alternative pneumococcal vaccine strategies. Tables outline basic and clinical issues and questions that remain to be addressed, and a summary of what is currently known and can be said about pneumococcal conjugate vaccines is provided. KW - conjugate vaccines KW - human diseases KW - reviews KW - vaccine development KW - vaccines KW - man KW - Streptococcus KW - Streptococcus pneumoniae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Streptococcaceae KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Streptococcus KW - bacterium KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004541&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of common lipooligosaccharide types in isolates from patients with otitis media by monoclonal antibodies against nontypeable Haemophilus influenzae 9274. AU - Ueyama, T. AU - Gu XinXing AU - Tsai ChaoMing AU - Karpas, A. B. AU - Lim, D. J. JO - Clinical and Diagnostic Laboratory Immunology JF - Clinical and Diagnostic Laboratory Immunology Y1 - 1999/// VL - 6 IS - 1 SP - 96 EP - 100 SN - 1071-412X AD - Ueyama, T.: Laboratory of Immunology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA. N1 - Accession Number: 19992005022. Publication Type: Journal Article. Language: English. Number of References: 24 ref. N2 - A total of 21 murine monoclonal antibodies (MAbs) were induced by nontypeable H. influenzae (NTHi) 9274. 19 MAbs were specific for the lipooligosaccharide (LOS) as determined by ELISA and Western blot analysis. When the MAbs were assayed with 5 LOS prototype strains by ELISA, all bound to strain 3198 LOS (type III), while 6 of the MAbs were also reactive with LOSs from strain 1479 (type I), 5657 (type IV) or 7502 (type V). Ten MAbs had complement-mediated bactericidal activity and 3 MAbs were opsonophagocytic against the homologous strain. Five LOS MAbs with different specificities were used to analyse 155 NTHi clinical isolates from the USA and Japan. These isolates were classified into 9 groups by ELISA. Only 4 isolates (2.6%) were not recognized by any of the 5 MAbs. Most of the isolates (91.6%) were in 4 groups which bound 3 of the 5 MAbs. One of 3 MAbs, 6347C11, had strong activity against the homologous strain and was also bactericidal to 45 clinical isolates (29%) which belonged to the 4 common patterns (25 belonged to pattern 1). It is suggested that these MAbs can be used for LOS typing in which almost all NTHi strains can be typed according to the LOS antigenicity. Among NTHi, at least one conserved LOS epitope which is a target of bactericidal antibodies exists. It is concluded that strain 9274 LOS, which is the target for bactericidal antibodies, is a candidate for LOS-based NTHi vaccines. KW - children KW - epitopes KW - human diseases KW - monoclonal antibodies KW - otitis media KW - Japan KW - USA KW - Haemophilus influenzae KW - man KW - Haemophilus KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - North America KW - America KW - antigenic determinants KW - bacterium KW - glue ear KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005022&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human uncoupling proteins and obesity. AU - Schrauwen, P. AU - Walder, K. AU - Ravussin, E. JO - Obesity Research JF - Obesity Research Y1 - 1999/// VL - 7 IS - 1 SP - 97 EP - 105 AD - Schrauwen, P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix AZ 85016, USA. N1 - Accession Number: 20001407427. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 56-65-5. Subject Subsets: Human Nutrition N2 - The headings of this review are: ATP consuming processes; non-ATP consuming processes; role of brown adipose tissue in energy metabolism; a novel UCP, UCP2; UCP in skeletal muscle, UCP3; role of UCP2 and UCP3 in obesity and energy expenditure; and regulation of UCP2 and UCP3 gene expression. KW - adipose tissue KW - ATP KW - brown fat KW - energy metabolism KW - gene expression KW - obesity KW - reviews KW - skeletal muscle KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adenosine triphosphate KW - fatness KW - uncoupling protein KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407427&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of taxol on the expression of transforming growth factor beta-1 in Ehrlich ascites carcinoma cells. AU - Saad, S. Y. AU - Ali, M. JO - Saudi Pharmaceutical Journal JF - Saudi Pharmaceutical Journal Y1 - 1999/// VL - 7 IS - 4 SP - 201 EP - 204 SN - 1319-0164 AD - Saad, S. Y.: Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. N1 - Accession Number: 20000310183. Publication Type: Journal Article. Language: English. Language of Summary: Arabic. Number of References: 15 ref. Registry Number: 33069-62-4. Subject Subsets: Horticultural Science N2 - Ehrlich ascites carcinoma cells (EAC) were relatively sensitive to taxol (from Taxus) and exhibited a significant apoptotic response following treatment in vitro. The effect of taxol treatment on the expression of transforming growth factor beta one (TGF-β1) in vitro was examined. EAC cell line (6×106 cell) were exposed to different concentrations of taxol for different intervals of time, and the amount of intracellular TGF-β1 was measured using ELISA technique and Western blotting. Results revealed that 50 nM of taxol is the optimum concentration at which TGF-β1 was expressed. Also TGF-β1 expression was maximum after 24 h of exposure to taxol rather than the other exposure times (2, 4 or 6 h). The mechanism of tumour responsiveness to taxol associated with increased expression of TGF-β1 is discussed. KW - cell lines KW - chemical composition KW - cytotoxic compounds KW - cytotoxicity KW - ELISA KW - growth factors KW - in vitro KW - medicinal plants KW - paclitaxel KW - plant composition KW - Taxus KW - Taxaceae KW - Taxopsida KW - gymnosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - chemical constituents of plants KW - drug plants KW - enzyme linked immunosorbent assay KW - medicinal herbs KW - officinal plants KW - taxol KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Non-wood Forest Products (KK540) KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000310183&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to Caucasians. AU - Weyer, C. AU - Pratley, R. E. JO - Obesity Research JF - Obesity Research Y1 - 1999/// VL - 7 IS - 5 SP - 444 EP - 452 AD - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 20001411497. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 57-88-5, 9004-10-8. Subject Subsets: Human Nutrition N2 - Plasma concentrations of acylation-stimulation protein (ASP), triglycerides (TG), free fatty acids (FFA), total cholesterol (CHOL), and insulin (INS) were measured in 15 Pima Indians (P) and 15 Caucasians (C) closely matched for age, sex, and body weight (7 lean and 8 obese subjects, body mass index (BMI) cut-off = 30), before and for 4 h after a standard mixed meal (20% of daily energy requirements, 41% carbohydrate, 44% fat, 15% protein). Fasting ASP was positively related to percent body fat (dual energy X-ray absorptiometry; r=0.49, p<0.01) and to TG and FFA, independently of percent body fat (partial r=0.42 and 0.46, respectively, both p<0.05). There were no differences in fasting TG, FFA, CHOL, INS, or ASP between lean C and lean P. In contrast, obese P had lower TG, lower CHOL, higher INS and, on average, 27% lower ASP compared to obese C. The ethnic difference in ASP remained after adjustment for TG, FFA, and percent body fat. ASP decreased in response to the meal in all 4 groups with no differences between groups. There was a significant inverse correlation between preprandial ASP and the change in FFA 60 min after the meal (r=0.56, p<0.001). Pima Indians do not have higher plasma ASP concentrations than Caucasians. Whether other alterations in the ASP-pathway, such as increased sensitivity of adipocytes to ASP, contribute to the high prevalence of obesity and low prevalence of dyslipidaemia in Pima Indians, remains to be elucidated. KW - anthropometric dimensions KW - blood chemistry KW - blood lipids KW - body fat KW - cholesterol KW - energy intake KW - ethnic groups KW - fatty acids KW - insulin KW - lipaemia KW - obesity KW - protein KW - triacylglycerols KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - acylation stimulation protein KW - anthropometric measurements KW - fatness KW - lipemia KW - triglycerides KW - Physiology of Human Nutrition (VV120) KW - Social Psychology and Social Anthropology (UU485) (New March 2000) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001411497&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quasispecies in viral persistence and pathogenesis of hepatitis C virus. AU - Forns, X. AU - Purcell, R. H. AU - Bukh, J. JO - Trends in Microbiology JF - Trends in Microbiology Y1 - 1999/// VL - 7 IS - 10 SP - 402 EP - 409 CY - Oxford; UK PB - Elsevier Science Ltd SN - 0966-842X AD - Forns, X.: Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20033098168. Publication Type: Journal Article. Language: English. Number of References: 73 ref. Subject Subsets: Public Health N2 - Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure. KW - chronic infections KW - genetic variation KW - hepatitis C KW - human diseases KW - molecular biology KW - molecular genetics KW - mutations KW - pathogenesis KW - reviews KW - hepatitis C virus KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - biochemical genetics KW - genetic variability KW - genotypic variability KW - genotypic variation KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - General Molecular Biology (ZZ360) (Discontinued March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033098168&site=ehost-live&scope=site UR - email: jbukh@niaid.nih.gov DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Role of dietary fat in the causation of breast cancer: point. AU - Greenwald, P. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1999/// VL - 8 IS - 1 SP - 3 EP - 7 SN - 1055-9965 AD - Greenwald, P.: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991412653. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Human Nutrition N2 - A review. KW - diet KW - fat KW - mammary gland neoplasms KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - mammary tumour KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412653&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors and risks for prostate cancer among blacks and whites in the United States. AU - Hayes, R. B. AU - Ziegler, R. G. AU - Gridley, G. AU - Swanson, C. AU - Greenberg, R. S. AU - Swanson, G. M. AU - Schoenberg, J. B. AU - Silverman, D. T. AU - Brown, L. M. AU - Pottern, L. M. AU - Liff, J. AU - Schwartz, A. G. AU - Fraumeni, J. F., Jr. AU - Hoover, R. N. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1999/// VL - 8 IS - 1 SP - 25 EP - 34 SN - 1055-9965 AD - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991412652. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 7440-70-2, 68-26-8. Subject Subsets: Human Nutrition N2 - Prostate cancer is the most common malignancy in men in the USA, with substantially higher rates among American blacks than whites. A population-based case-control study was undertaken in three geographic areas of the USA to evaluate the reasons for the racial disparity in incidence rates. A total of 932 men (449 black men and 483 white men) who had been newly diagnosed with pathologically confirmed prostate cancer and 1201 controls (543 black men and 658 white men) were interviewed in person to elicit information on potential risk factors. This report evaluates the impact of dietary factors, particularly the consumption of animal products and animal fat, on the risk of prostate cancer among blacks and whites in the USA. Increased consumption (g/day) of foods high in animal fat was linked to prostate cancer (independent of intake of other calories) among American blacks [by quartile of intake, odds ratio (OR) =1.0 (referent), 1.5, 2.1, and 2.0; Ptrend = 0.007], but not among American whites [by quartile of intake, OR = 1.0 (referent), 1.6, 1.5, and 1.1; Ptrend = 0.90]. However, risks for advanced prostate cancer were higher with greater intake of foods high in animal fat among blacks [by quartile of intake, OR = 1.0 (referent), 2.2, 4.2, and 3.1; Ptrend = 0.006] and whites [by quartile of intake, OR = 1.0 (referent), 2.2, 2.6, and 2.4; Ptrend = 0.02]. Increased intake of animal fat as a proportion of total caloric intake also showed positive but weaker associations with advanced prostate cancer among blacks (Ptrend = 0.13) and whites (Ptrend = 0.08). No clear associations were found with vitamin A, calcium, or specific lycopene-rich foods. The study linked greater consumption of fat from animal sources to increased risk for prostate cancer among American blacks and to advanced prostate cancer among American blacks and whites. KW - animal fat KW - animal products KW - calcium KW - diet KW - ethnic groups KW - fat KW - neoplasms KW - prostate KW - retinol KW - risk KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412652&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The anti-carcinogenic role of lycopene, abundantly present in tomato. AU - Sengupta, A. AU - Das, S. JO - European Journal of Cancer Prevention JF - European Journal of Cancer Prevention Y1 - 1999/// VL - 8 IS - 4 SP - 325 EP - 330 SN - 0959-8278 AD - Sengupta, A.: Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37 S P. Mukherjee Road, Calcutta 700026, India. N1 - Accession Number: 19991414227. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 502-65-8. Subject Subsets: Human Nutrition KW - antineoplastic agents KW - antioxidants KW - blood chemistry KW - breast cancer KW - carotenoids KW - composition KW - fruit vegetables KW - lycopene KW - neoplasms KW - pancreatic cancer KW - prevention KW - prostate cancer KW - tomatoes KW - vitamins KW - Solanum KW - Solanum lycopersicum KW - Solanum KW - Solanaceae KW - Solanales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - cancers KW - cytotoxic agents KW - Lycopersicon KW - Lycopersicon esculentum KW - metaanalysis KW - tetraterpenoids KW - Crop Produce (QQ050) KW - Food Composition and Quality (QQ500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414227&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of α-tocopherol and β-carotene supplementation on colorectal adenomas in middle-aged male smokers. AU - Malila, N. AU - Virtamo, J. AU - Virtanen, M. AU - Albanes, D. AU - Tangrea, J. A. AU - Huttunen, J. K. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1999/// VL - 8 IS - 6 SP - 489 EP - 493 SN - 1055-9965 AD - Malila, N.: Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20001408705. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7235-40-7, 1406-18-4. Subject Subsets: Human Nutrition N2 - This study was carried out within the α-Tocopherol, β-Carotene Cancer Prevention Study (ATBC Study), whose participants were randomly assigned to 4 supplementation groups: (a) α-tocopherol (AT), 50 mg/day; (b) β-carotene (BC), 20 mg/day; (c) both AT and BC; and (d) placebo. 15 538 ATBC Study participants (aged 50-69 years) who had been randomized within the areas of 3 major cities in southern Finland were included. Cases of colorectal adenoma (n=146) were identified by the pathology laboratories in the study areas, and these participants' medical records were collected and reviewed. α-Tocopherol supplementation increased the risk for adenomas (relative risk, 1.66; 95% confidence interval, 1.19-2.32), whereas β-carotene supplementation had no effect on the risk (relative risk, 0.98; 95% confidence interval, 0.71-1.35). Slightly more pre-diagnosis rectal bleeding and intestinal pain occurred in those adenoma cases who received α-tocopherol supplements than in those who did not. Thus, some bias may have resulted, with α-tocopherol supplementation leading to more colonoscopies and, thus, to an increased detection of incident polyps in this group. This is further supported by the trial finding that α-tocopherol supplementation did not increase the risk of colorectal cancer. KW - adenoma KW - beta-carotene KW - colorectal cancer KW - digestive tract KW - men KW - neoplasms KW - risk factors KW - supplements KW - tobacco smoking KW - vitamin E KW - vitamins KW - Finland KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - gastrointestinal tract KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001408705&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of vitamin intervention on the relationship between GSTM1, smoking, and lung cancer risk among male smokers. AU - Woodson, K. AU - Stewart, C. AU - Barrett, M. AU - Bhat, N. K. AU - Virtamo, J. AU - Taylor, P. R. AU - Albanes, D. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1999/// VL - 8 IS - 11 SP - 965 EP - 970 SN - 1055-9965 AD - Woodson, K.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892-7058, USA. N1 - Accession Number: 20001412645. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 59-02-9, 7235-40-7, 50812-37-8, 1406-18-4. Subject Subsets: Human Nutrition N2 - The GSTM1 (glutathione S-transferase mu-1) null genotype is suspected of increasing an individual's susceptibility to tobacco smoke carcinogens because of impaired carcinogen detoxification. The aim of this work was to discover whether there were differences in lung cancer susceptibility to smoking within the GSTM1 genotypes and the impact of antioxidant supplementation on this. The study was a nested lung cancer case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. GSTM1 genotype status was determined for 319 cases and 333 controls using a PCR-based approach. GSTM1 was evaluated as an independent risk factor and as an effect modifier of smoking using logistic regression analyses. The GSTM1 null genotype itself was unrelated to risk of lung cancer, odds ratio (OR)=1.09 and 95% confidence interval (CI), 0.79-1.50, but it may have modified the effect of smoking. There was a suggestion for a stronger association between years of smoking and lung cancer among the GSTM1 null genotype, but the differences between GSTM1 null and present genotypes were not statistically significant (P=0.12). Furthermore, the smoking association was strongest among those with the GSTM1 null genotype not receiving α-tocopherol supplementation, whereas among those receiving α-tocopherol, there was no modification by GSTM1 on the association between smoking duration and lung cancer risk. β-Carotene supplementation did not modify the relationship between GSTM1, smoking years, and lung cancer risk. In conclusion, GSTM1 is not associated with lung cancer risk in male smokers but may confer a higher susceptibility to cumulative tobacco exposure. This association may be attenuated by α-tocopherol but not by β-carotene supplementation. KW - alpha-tocopherol KW - antioxidants KW - beta-carotene KW - genotypes KW - glutathione transferase KW - lung cancer KW - neoplasms KW - risk KW - supplements KW - susceptibility KW - tobacco smoking KW - vitamin E KW - Finland KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - ligandin KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412645&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effect of β-carotene supplementation on serum vitamin D metabolite concentrations. AU - Freedman, D. M. AU - Tangrea, J. A. AU - Virtamo, J. AU - Albanes, D. JO - Cancer Epidemiology, Biomarkers & Prevention JF - Cancer Epidemiology, Biomarkers & Prevention Y1 - 1999/// VL - 8 IS - 12 SP - 1115 EP - 1116 SN - 1055-9965 AD - Freedman, D. M.: Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 7087, 6220 Executive Boulevard, Bethesda, Maryland 20892-7238, USA. N1 - Accession Number: 20001417926. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 59-02-9, 7235-40-7, 32222-06-3, 1406-16-2. Subject Subsets: Human Nutrition N2 - In the α-Tocopherol, β-Carotene Cancer Prevention (ATBC) study, a large randomized placebo-controlled trial designed to test the cancer prevention effects of α-tocopherol (50 mg/day) and β-carotene (20 mg/day), participants receiving supplemental β-carotene had significantly higher rates of lung cancer than those not receiving β-carotene. It has been hypothesized that the supplemental β-carotene may have interfered with the synthesis of vitamin D and that the resulting lower concentrations of vitamin D contributed to the elevated cancer incidence. We evaluated whether supplementation with β-carotene altered the serum concentrations of either 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D in the ATBC Study, by comparing on-study changes between baseline and follow-up serum samples among 20 randomly selected matched pairs of subjects from the β-carotene and placebo groups. In a matched-pair analysis, the difference between the changes in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the β-carotene supplement and placebo groups were small and statistically non-significant. These results provide no evidence that β-carotene supplementation interferes with the endogenous production of 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D and suggest that it is unlikely that an interaction between supplemental β-carotene and vitamin D metabolites contributed to the modest increase in lung cancer incidence observed in the ATBC Study. KW - alpha-tocopherol KW - beta-carotene KW - calcitriol KW - lung cancer KW - lungs KW - neoplasms KW - prevention KW - synthesis KW - vitamin D KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - 1,25-dihydroxycholecalciferol KW - 1,25-dihydroxyvitamin D KW - cancers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001417926&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adipose S14 mRNA is abnormally regulated in obese subjects. AU - Kirschner, L. S. AU - Mariash, C. N. JO - Thyroid JF - Thyroid Y1 - 1999/// VL - 9 IS - 2 SP - 143 EP - 148 AD - Kirschner, L. S.: National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19991412858. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - In rat hepatocyte culture, the S14 gene is necessary for induction of lipogenesis by carbohydrate metabolism and thyroid hormone. To determine if this gene plays a role in regulation of lipid storage in man, the response to fasting of the human S14 gene was compared in obese and nonobese subjects. The relative content of human S14 mRNA was measured in abdominal subcutaneous fat before and after a 48-h fast. mRNA-S14 was strongly downregulated in nonobese subjects in response to the fast, but only minimally down-regulated in obese subjects. There was an excellent correlation between body mass index, and the fasting induced fall in S14 mRNA. There was no difference in the postfasting glucose, insulin, and ketone levels between the 2 groups of subjects. Therefore, the S14 gene is abnormally downregulated during fasting in adipose tissue of obese individuals. Further study of this gene could provide important information on the mechanism of the acquisition or maintenance of obesity in man. KW - adipose tissue KW - anthropometric dimensions KW - body measurements KW - carbohydrate metabolism KW - fasting KW - genetics KW - height KW - insulin KW - lipogenesis KW - messenger RNA KW - obesity KW - regulation KW - storage KW - thyroid gland KW - thyroid hormones KW - weight KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - anthropometric measurements KW - fatness KW - lipid formation KW - mRNA KW - thyroid KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412858&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human herpesvirus 7. AU - Black, J. B. AU - Pellett, P. E. JO - Reviews in Medical Virology JF - Reviews in Medical Virology Y1 - 1999/// VL - 9 IS - 4 SP - 245 EP - 262 SN - 1052-9276 AD - Black, J. B.: National Institutes of Health, National Cancer Institute, HIV and AIDS Malignancy Branch, 10 Center Drive Building 10, Room 13N240, Bethesda, MD 20892, USA. N1 - Accession Number: 20002007398. Publication Type: Journal Article. Language: English. Number of References: 114 ref. Subject Subsets: Public Health N2 - Biological properties (isolation and propagation, life cycle, latency and persistence and effect on host cell), genomic and genetic properties, proteins, epidemiology and disease associations, diagnostic tools, and treatment are reviewed. KW - clinical aspects KW - diagnosis KW - drug therapy KW - epidemiology KW - genetics KW - human diseases KW - pathogenesis KW - proteins KW - reviews KW - Herpesviridae KW - human herpesvirus 7 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Roseolovirus KW - Betaherpesvirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - clinical picture KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Diagnosis of Human Disease (VV720) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007398&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Iron status and the risk of coronary heart disease. AU - Sempos, C. T. AU - Looker, A. C. JO - Nutrition Metabolism and Cardiovascular Diseases JF - Nutrition Metabolism and Cardiovascular Diseases Y1 - 1999/// VL - 9 IS - 6 SP - 294 EP - 303 CY - Milano; Italy PB - Medikal Press s.r.l. SN - 0939-4753 AD - Sempos, C. T.: Office of Research on Minority Health, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 20013024889. Publication Type: Journal Article. Language: English. Number of References: 102 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition N2 - This article reviews the epidemiological evidence that body iron stores may be directly associated with an increased risk of CHD or indirectly associated through such oxidation. KW - cardiovascular diseases KW - heart diseases KW - iron KW - nutritional state KW - reviews KW - risk factors KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - coronary diseases KW - nutritional status KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013024889&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. AU - Slattery, J. P. AU - Franchini, G. AU - Gessain, A. JO - Genome Research JF - Genome Research Y1 - 1999/// VL - 9 IS - 6 SP - 525 EP - 540 AD - Slattery, J. P.: Laboratory of Genomic Diversity, National Cancer Institute-Frederick Research Development Center (NCI-FCRDC) Frederick, Maryland 21702, USA. N1 - Accession Number: 19992011572. Publication Type: Journal Article. Language: English. Number of References: 4 pp of ref. N2 - Using both env and long terminal repeat (LTR) sequences, with maximal representation of genetic diversity within primate strains, the unique evolutionary history of human and simian T-cell leukemia/lymphotropic viruses (HTLV/STLV) is revised and expanded. Based on the robust application of 3 different phylogenetic algorithms of minimum evolution-neighbour joining, maximum parsimony, and maximum likelihood, overall levels of genetic diversity, specific rates of mutation within and between different regions of the viral genome, relatedness among viral strains from geographically diverse regions, and estimation of the pattern of divergence of the virus into extant lineages are addressed. Despite broad genomic similarities, type I and type II viruses do not share concordant evolutionary histories. HTLV-I/STLV-I are united through distinct phylogeographic patterns, infection of 20 primate species, multiple episodes of interspecies transmission, and exhibition of a range in levels of genetic divergence. In contrast, type II viruses are isolated from only 2 species (Homo sapiens and Pan paniscus) and are paradoxically endemic to both Amerindian tribes of the New World and human Pygmy villagers in Africa. Furthermore, HTLV-II is spreading rapidly through new host populations of intravenous drug users. Despite such clearly disparate host populations, the resultant HTLV-II/STLV-II phylogeny exhibits little phylogeographic concordance and indicates low levels of transcontinental genetic differentiation. Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion. KW - evolution KW - genetic diversity KW - genetics KW - human diseases KW - mutations KW - phylogenetics KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - man KW - Primates KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - simian t-cell lymphotropic virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011572&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). AU - Dorgan, J. F. AU - Brock, J. W. AU - Rothman, N. AU - Needham, L. L. AU - Miller, R. AU - Stephenson, H. E., Jr. AU - Schussler, N. AU - Taylor, P. R. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1999/// VL - 10 IS - 1 SP - 1 EP - 11 SN - 0957-5243 AD - Dorgan, J. F.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Room 443, 6130 Executive Boulevard, Bethesda, MD 20892-7374, USA. N1 - Accession Number: 20002008216. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 118-74-1. N2 - To prospectively evaluate relationships of organochlorine pesticides and polychlorinated biphenyls (PCBs) with breast cancer, a case-control study nested in a cohort was conducted in the USA using the Columbia, Missouri Breast Cancer Serum Bank. Women donated blood in 1977-87, and during up to 9.5 years follow-up, 105 donors who met the inclusion criteria for the current study were diagnosed with breast cancer. For each case, 2 controls matched on age and date of blood collection were selected. Five DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] analogs, 13 other organochlorine pesticides, and 27 PCBs were measured in serum. Women in the upper 3 quartiles of hexachlorobenzene were at twice the risk of breast cancer compared to those in the lowest quartile. However, there was no evidence for a dose-response relationship, and the association was limited to women whose blood was collected close to the time of diagnosis. Women with higher serum levels of other organochlorine pesticides and PCBs showed no increased risk of breast cancer overall, although positive associations were suggested for PCB-118 and PCB-138 when blood was collected close to the time of diagnosis. It is concluded that results of this study do not support a role for organochlorine pesticides and PCBs in breast cancer aetiology. KW - aetiology KW - breast cancer KW - epidemiology KW - hexachlorobenzene KW - human diseases KW - neoplasms KW - organochlorine compounds KW - organochlorine pesticides KW - polychlorinated biphenyls KW - risk factors KW - women KW - Missouri KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancers KW - causal agents KW - etiology KW - HCB KW - organic chlorine compounds KW - organic chlorine pesticides KW - PCBs KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002008216&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Tobacco and alcohol use and oral cancer in Puerto Rico. AU - Hayes, R. B. AU - Bravo-Otero, E. AU - Kleinman, D. V. AU - Brown, L. M. AU - Fraumeni, J. F., Jr. AU - Harty, L. C. AU - Winn, D. M. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1999/// VL - 10 IS - 1 SP - 27 EP - 33 SN - 0957-5243 AD - Hayes, R. B.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPN 418, Bethesda, MD 20892, USA. N1 - Accession Number: 20001409128. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition N2 - In Puerto Rico, alcohol and tobacco use were compared among non-salivary gland cancers of the mouth and pharynx (n=342), cancers of major and minor salivary glands (n=25) and 521 population-based controls. Alcohol (usual use, Ptrend<0.0001 for men and Ptrend=0.02 for women) and tobacco (usual use, Ptrend<0.0001, for both men and women) were strong independent risk factors for oral cancer in Puerto Rico, with a multiplicative effect from combined exposures. Risks did not vary systematically by use of filter vs non-filter cigarettes. Risks with use of other forms of smoked tobacco were about sevenfold among both men and women. Risks decreased only gradually after cessation of tobacco and alcohol use. Tobacco use, but not alcohol, was linked to cancers of the salivary glands. The burden of oral cancer due to alcohol and tobacco use in Puerto Rico (76% for men, 52% for women) agreed closely with earlier estimates for the mainland US population, while about 72% of salivary gland cancer (men and women, combined) was due to tobacco use. It is concluded that excess risks for oral cancer in Puerto Rico are largely explained by patterns of alcohol and tobacco use. Smoking filter vs non filter cigarettes does not alter risk, while cessation of alcohol and tobacco use appears to reduce risk only gradually. KW - alcoholic beverages KW - consumption KW - head and neck cancer KW - men KW - mouth KW - neoplasms KW - pharynx KW - risk factors KW - salivary glands KW - tobacco smoking KW - women KW - Puerto Rico KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - cancers KW - Porto Rico KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) KW - Sugar and Sugar Products (QQ020) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001409128&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Calculation of population attributable risk for alcohol and breast cancer (United States). AU - Tseng, M. AU - Weinberg, C. R. AU - Umbach, D. M. AU - Longnecker, M. P. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1999/// VL - 10 IS - 2 SP - 119 EP - 123 SN - 0957-5243 AD - Tseng, M.: National Institute of Environmental Health Sciences Epidemiology Branch, Research Triangle Park, P.O. Box 12233 MD A3-05, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 20001410742. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition N2 - Because of increasing evidence that alcohol may be causally associated with breast cancer, the population attributable risk (PAR) for alcohol and breast cancer for the US adult female population was reconsidered using an effect estimate from a meta-analysis and incorporating a revised perspective on measurement error correction. To estimate PAR, a formula appropriate to use with an adjusted effect estimate was employed. To estimate intermediate quantities needed to apply that formula, adjusted relative risk estimates from a previously published meta-analysis, as well as SEER cancer statistics and general population data from the third National Health and Nutrition Examination Survey were used. Relative risk estimates uncorrected for measurement error were used. The estimated age-adjusted PAR for alcohol and breast cancer was 2.1%. Because of the modest association between alcohol and breast cancer and the generally moderate level of alcohol intake among US women, the proportion of breast cancer attributable to alcohol intake is small. Widespread efforts to reduce alcohol consumption would not have a substantial impact on breast cancer rates in this population. While selected subgroups of women might benefit from decreasing alcohol consumption, specific profiles for such women have yet to be defined and defended. KW - alcoholic beverages KW - breast cancer KW - consumption KW - diet KW - neoplasms KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - United States of America KW - Sugar and Sugar Products (QQ020) KW - Human Nutrition (General) (VV100) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland. AU - Woodson, K. AU - Albanes, D. AU - Tangrea, J. A. AU - Rautalahti, M. AU - Virtamo, J. AU - Taylor, P. R. JO - Cancer Causes & Control JF - Cancer Causes & Control Y1 - 1999/// VL - 10 IS - 3 SP - 219 EP - 226 SN - 0957-5243 AD - Woodson, K.: Cancer Prevention Studies Branch, 6006 Executive Boulevard - Suite 321, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-7058, USA. N1 - Accession Number: 20001411516. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition N2 - The association between alcohol intake and lung cancer was evaluated in a trial-based cohort in Finland, the α-tocopherol, β-carotene Cancer Prevention Study (ATBC Study). During an average of 7.7 years of follow-up, 1059 lung cancer cases were diagnosed among the 27 111 male smokers with complete alcohol and dietary information. The relationship between alcohol and lung cancer was assessed in multivariate Cox regression models that adjusted for age, smoking, body mass index and intervention group. Non drinkers, 11% of the study population, were at increased lung cancer risk compared to drinkers (RR=1.2, 95% CI: 1.0-1.4), possibly due to the inclusion of ex-drinkers who had stopped drinking for health reasons. Among drinkers only, no association between lung cancer and total ethanol or specific beverage (beer, wine, spirits) intake were observed. No significant effect of modification by level of smoking, dietary micronutrients or trial intervention group was found; however, for men in the highest quartile of alcohol intake, a slight increase in risk for lighter smokers (<1 pack/day) and reduced risk among the heaviest smokers (>30 cigarettes/day) was observed. It is concluded that alcohol consumption was not a risk factor for lung cancer among male cigarette smokers, and its effect was not significantly modified by other factors, notably smoking history. KW - alcoholic beverages KW - anthropometric dimensions KW - consumption KW - diet KW - lifestyle KW - lung cancer KW - men KW - neoplasms KW - nutrition surveys KW - tobacco smoking KW - Finland KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - anthropometric measurements KW - cancers KW - nutritional surveys KW - Non-communicable Human Diseases and Injuries (VV600) KW - Human Nutrition (General) (VV100) KW - Sugar and Sugar Products (QQ020) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001411516&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum HIV-1 p24 antibody, HIV-1 RNA copy number and CD4 lymphocyte percentage are independently associated with risk of mortality in HIV-1-infected children. AU - Mofenson, L. M. AU - Harris, D. R. AU - Rich, K. AU - Meyer, W. A. AU - Read, J. S. AU - Moye, J., Jr. AU - Nugent, R. P. AU - Korelitz, J. AU - Bethel, J. AU - Pahwa, S. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 IS - 1 SP - 31 EP - 39 SN - 0269-9370 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children National Institute of Child Health and Human Development, Westat, Rockville, Maryland, USA. N1 - Accession Number: 19992007107. Publication Type: Journal Article. Corporate Author: National Institute of Child Health and Human Development USA, Intravenous Immunoglobulin Clinical Trial Study Group Language: English. Number of References: 43 ref. Registry Number: 63231-63-0. N2 - The association between HIV-1 p24 antibody, HIV-1 RNA, immune complex-dissociated (ICD) p24 antigen, CD4 cell percentage and mortality were evaluated in a cohort of 218 HIV-infected children. The children were enrolled in mainland USA and Puerto Rico during March 1988 to January 1991 in a trial of intravenous immunoglobulin prophylaxis of bacterial infections. CD4 cell percentage was measured and sera collected and stored at baseline and every 3 months. Stored sera were assayed for HIV-1 p24 antibody, HIV-1 RNA, and ICD p24 antigen. Mortality was recorded during the trial and updated through 1996 (mean total follow-up, 6.3 years). 81 children (37%) died; probability of mortality for children with baseline HIV-1 p24 antibody concentrations of undetectable (<1), 1-4, 5-124 and ≥125 reciprocal titre units (RTU) was 61, 50, 24 and 10%, respectively. A 3.5-fold increase in the relative risk (RR) of death (95% confidence interval (CI), 2.2-5.5) was observed among children with baseline HIV-1 p24 antibody concentration <5 RTU compared with ≥5 RTU. In multivariate analyses, p24 antibody, HIV-1 RNA and CD4 cell percentage, but not ICD p24 antigen, were independently associated with mortality; the RR of death increased by 1.7 (95% CI, 1.3-2.1) for each log10 decrease in baseline HIV-1 p24 antibody. It is concluded that HIV-1 p24 antibody, HIV-1 RNA and CD4 cell percentage independently predict mortality amongst infected children. Whereas CD4 cell percentage provides an estimate of the general degree of immune suppression, HIV-1 p24 antibody could provide an easily obtained, inexpensive assessment of CD4 cell function and could augment prognostic information provided by CD4 cell count and viral load for clinical management of infected children. KW - CD4+ lymphocytes KW - children KW - core protein p24 KW - human diseases KW - mortality KW - risk factors KW - RNA KW - viral diseases KW - Colombia KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - CD4+ cells KW - death rate KW - human immunodeficiency virus type 1 KW - p24 KW - p24 antigen KW - ribonucleic acid KW - T4 lymphocytes KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007107&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero. AU - Olivero, O. A. AU - Shearer, G. M. AU - Chougnet, C. A. AU - Kovacs, A. A. S. AU - Landay, A. L. AU - Baker, R. AU - Stek, A. M. AU - Khoury, M. M. AU - Proia, L. A. AU - Kessler, H. A. AU - Sha, B. E. AU - Tarone, R. E. AU - Poirier, M. C. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 IS - 8 SP - 919 EP - 925 SN - 0269-9370 AD - Olivero, O. A.: Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19992008672. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9007-49-2, 30516-87-1. N2 - In this prospective cohort study conducted in Chicago, Illinois, USA, DNA was extracted from peripheral blood mononuclear cells (PBMC) obtained from 28 non-pregnant adults and 12 pregnant women given zidovudine (ZDV) therapy, 6 non-pregnant adults with no exposure to ZDV and 6 non-pregnant adults who last received ZDV ≥6 months previously. In addition, DNA from cord blood leukocytes obtained from 22 infants of HIV-1-positive, ZDV-exposed women and from 12 infants unexposed to ZDV was analysed. There were 11 mother-infant pairs involving HIV-1-positive women. DNA samples were assayed for ZDV incorporation by anti-ZDV radioimmunoassay (RIA). The majority (76%) of samples from ZDV-exposed individuals, pregnant women (8 of 12), non-pregnant adults (24 of 28), or infants at delivery (15 of 22), had detectable ZDV-DNA levels. The range of positive values for ZDV-treated adults and infants was 25-544 and 22-452 molecules ZDV/106 nucleotides, respectively. Analysis of 11 mother-infant pairs showed variable ZDV-DNA incorporation in both, with no correlation by pair or by duration of drug treatment during pregnancy. Two of the 24 samples from individuals designated as controls were positive by anti-ZDV RIA. The 20-fold range for ZDV-DNA values in both adults and infants suggested large interindividual differences in ZDV phosphorylation. In conclusion, incorporation of ZDV into DNA was detected in most of the samples from ZDV-exposed adults and infants. The interindividual variability of ZDV incorporation into DNA in humans is considerable and consistent with reported variability in the formation of the ZDV-trisphosphate. KW - blood KW - cord blood KW - DNA KW - drug therapy KW - HIV-1 infections KW - human diseases KW - neonates KW - phosphorylation KW - pregnancy KW - zidovudine KW - Illinois KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - East North Central States of USA KW - AZT KW - chemotherapy KW - deoxyribonucleic acid KW - gestation KW - human immunodeficiency virus type 1 KW - newborn infants KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008672&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-specific immunity following immunization with HIV synthetic envelope peptides in asymptomatic HIV-infected patients. AU - Pinto, L. A. AU - Berzofsky, J. A. AU - Fowke, K. R. AU - Little, R. F. AU - Merced-Galindez, F. AU - Humphrey, R. AU - Ahlers, J. AU - Dunlop, N. AU - Cohen, R. B. AU - Steinberg, S. M. AU - Nara, P. AU - Shearer, G. M. AU - Yarchoan, R. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 IS - 15 SP - 2003 EP - 2012 SN - 0269-9370 AD - Pinto, L. A.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Bethesda Maryland 20892, USA. N1 - Accession Number: 20002006138. Publication Type: Journal Article. Language: English. Number of References: 54 ref. N2 - A phase I trial was conducted in the USA to evaluate the safety and immunogenicity of an HIV synthetic peptide vaccine in HIV-seropositive individuals [date not given]. The immunogens used in this study were PCLUS 3-18MN and PCLUS 6.1-18MN envelope peptides. Eight HIV-infected patients received six subcutaneous injections of 160 µg PCLUS 3-18MN in Montanide ISA 51 and were followed longitudinally for a year after the first immunization. Peripheral blood mononuclear cells (PBMC) were tested for peptide-specific T helper and cytotoxic T cell (CTL) responses, HIV-1MN neutralizing antibodies and antibodies against HIV PCLUS 3 and P18 MN peptides. PCLUS 3-18MN-specific T helper responses were significantly increased at 36 weeks (P<0.05, after adjustment for multiple comparisons) following initial immunization with PCLUS 3-18MN. A P18MN-specific CTL response, not present prior to vaccination, was observed after immunization in one patient. Serum HIV-1MN-neutralizing antibody titres increased in each of the three patients who had low titres prior to immunization. Plasma HIV RNA levels and CD4 cell counts did not change appreciably during the study period. This trial demonstrates that both peptides can be safely administered to HIV-infected individuals and that PCLUS 3-18MN induces increases in HIV peptide-specific immune responses. KW - antigens KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - immunization KW - neutralizing antibodies KW - safety KW - synthetic peptides KW - T lymphocytes KW - vaccination KW - vaccines KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006138&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Molecular interactions of HIV with host factors. AU - Strebel, K. AU - Bour, S. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 SP - S13 EP - S24 SN - 0269-9370 AD - Strebel, K.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. N1 - Accession Number: 19992011736. Publication Type: Journal Article. Language: English. Number of References: 160 ref. KW - gene expression KW - HIV infections KW - host parasite relationships KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - molecular biology KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011736&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immune reconstitution in HIV infection. AU - Gea-Banacloche, J. C. AU - Lane, H. C. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 SP - S25 EP - S38 SN - 0269-9370 AD - Gea-Banacloche, J. C.: Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19992011737. Publication Type: Journal Article. Language: English. Number of References: 163 ref. KW - CD4+ lymphocytes KW - CD8+ lymphocytes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immune response KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4+ cells KW - CD8+ cells KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - immunity reactions KW - immunological reactions KW - T4 lymphocytes KW - T8 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011737&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of nonhuman primates in the development of an AIDS vaccine. AU - Nathanson, N. AU - Hirsch, V. M. AU - Mathieson, B. J. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 SP - S113 EP - S120 SN - 0269-9370 AD - Nathanson, N.: Office of AIDS Research, National Institutes of Health, US Department of Health and Human Services, Room 4C02, Building 31, 9000 Rockville Pike, Bethesda, MD 20892-2340, USA. N1 - Accession Number: 19992011743. Publication Type: Journal Article. Language: English. Number of References: 74 ref. KW - acquired immune deficiency syndrome KW - animal models KW - disease models KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - reviews KW - vaccine development KW - vaccines KW - man KW - Primates KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011743&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies. AU - Erickson, J. W. AU - Gulnik, S. V. AU - Markowitz, M. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 SP - S189 EP - S204 SN - 0269-9370 AD - Erickson, J. W.: Structural Biochemistry Program, SAIC-Frederick, National Cancer Institute-FCRDC, Frederick, MD 21702, USA. N1 - Accession Number: 19992011748. Publication Type: Journal Article. Language: English. Number of References: 88 ref. KW - antiviral agents KW - cross resistance KW - drug resistance KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - proteinase inhibitors KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - protease inhibitors KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011748&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interruption of materno-fetal transmission. AU - Mofenson, L. M. AU - Fowler, M. G. JO - AIDS JF - AIDS Y1 - 1999/// VL - 13 SP - S205 EP - S214 SN - 0269-9370 AD - Mofenson, L. M.: Clinical Research, Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Rockville, MD 20852, USA. N1 - Accession Number: 19992011749. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 30516-87-1. KW - antiviral agents KW - disease prevention KW - disease transmission KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - pregnancy KW - prophylaxis KW - reviews KW - zidovudine KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AZT KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011749&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rickettsiae and chlamydiae: evidence of horizontal gene transfer and gene exchange. AU - Wolf, Y. I. AU - Aravind, L. AU - Koonin, E. V. JO - Trends in Genetics JF - Trends in Genetics Y1 - 1999/// VL - 15 IS - 5 SP - 173 EP - 175 SN - 0168-9525 AD - Wolf, Y. I.: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. N1 - Accession Number: 20000503304. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology KW - gene transfer KW - hosts KW - molecular genetics KW - Chlamydia trachomatis KW - Rickettsia prowazekii KW - Chlamydia KW - Chlamydiaceae KW - Chlamydiales KW - Chlamydiae KW - Bacteria KW - prokaryotes KW - Rickettsia KW - Rickettsiaceae KW - Rickettsiales KW - Alphaproteobacteria KW - Proteobacteria KW - bacterium KW - biochemical genetics KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000503304&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Oral immunisation of mice with live Japanese encephalitis virus induces a protective immune response. AU - Ramakrishna, C. AU - Anita Desai AU - Shankar, S. K. AU - Chandramuki, A. AU - Ravi, V. JO - Vaccine JF - Vaccine Y1 - 1999/// VL - 17 IS - 23/24 SP - 3102 EP - 3108 SN - 0264-410X AD - Ramakrishna, C.: Department of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India. N1 - Accession Number: 19990506007. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology N2 - The efficacy of oral immunization of mice with live Japanese encephalitis virus (JEV) was evaluated. Swiss albino mice were immunized with JEV by the peroral (PO), intraperitoneal (IP) and the subcutaneous (SC) routes on days 0, 7 and 14 using either mouse brain derived immunogen (MBDI) or cell culture derived immunogen (CCDI). Oral immunization of mice evoked high anti-JEV antibody titres by ELISA (Geometric mean titres of 5065 with CCDI and 8854 with MBDI). Moreover, the orally immunized mice showed 76.7% protection with MBDI and 70% with CCDI against intracerebral challenge with a lethal dose of JEV. This study demonstrates for the first time that oral immunization of mice with live JEV generates a brisk, protective immune response. KW - antibodies KW - arboviruses KW - immune response KW - immunization KW - Japanese encephalitis KW - laboratory animals KW - Japanese encephalitis virus KW - mice KW - Flavivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - arthropod-borne viruses KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506007&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Serum vitamin A concentrations in a North American cohort of human immunodeficiency virus type 1-infected children. AU - Read, J. S. AU - Bethel, J. AU - Harris, D. R. AU - Meyer, W. A., III AU - Korelitz, J. AU - Mofenson, L. M. AU - Moye, J., Jr. AU - Savita Pahwa AU - Rich, K. AU - Nugent, R. P. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1999/// VL - 18 IS - 2 SP - 134 EP - 142 SN - 0891-3668 AD - Read, J. S.: Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA. N1 - Accession Number: 19991405703. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - The study measured serum retinol concentrations among 207 HIV-infected children (aged between 1 month and 12 years) in the National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial, between 1988-1991. Changes in retinol concentrations were examined and the relationships between retinol concentrations and morbidity and mortality were investigated. Blood was collected from children at baseline and at 3-month intervals throughout the study. The rate of change in retinol concentrations, calculated by fitting a linear regression model, was expressed as µg/dl yearly. The median retinol concentration at baseline was 31.0 µg/dl. The rate of change in retinol concentrations (n=180) did not vary significantly by any factor other than baseline retinol concentration. Baseline retinol concentration was not associated with morbidity (incidence of infections, growth failure, CD4+ percent decline below 15%, increases in serum HIV RNA concentrations above either 105 or 106 copies/ml or acute care hospitalization). Neither baseline retinol concentration nor the rate of change of retinol concentration was associated with mortality. It is concluded that among these North American children with relatively normal retinol concentrations, retinol was not observed to be associated with morbidity or mortality. KW - blood KW - blood chemistry KW - children KW - HIV infections KW - human immunodeficiency viruses KW - infants KW - morbidity KW - mortality KW - retinol KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - death rate KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Human Physiology and Biochemistry (VV050) KW - Physiology of Human Nutrition (VV120) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991405703&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Increased adherence of fluconazole-resistant isolates of Candida species to explanted esophageal mucosa. AU - Lyman, C. A. AU - Garrett, K. F. AU - Peter, J. AU - Gonzalez, C. AU - Walsh, T. J. JO - European Journal of Clinical Microbiology & Infectious Diseases JF - European Journal of Clinical Microbiology & Infectious Diseases Y1 - 1999/// VL - 18 IS - 3 SP - 213 EP - 216 SN - 0934-9723 AD - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991201675. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 86386-73-4. Subject Subsets: Medical & Veterinary Mycology N2 - The adherence of fluconazole-resistant and fluconazole-susceptible isolates of C. albicans to explanted rabbit oesophageal mucosa was examined in vivo. Among 6 C. albicans isolates collected from HIV-infected patients, 3 fluconazole-resistant (MIC >64 µg/ml) isolates attached more avidly than 3 fluconazole-susceptible strains (MIC ≤0.5 µg/ml) to oesophageal mucosa (P≤0.05). When 3 strains each of 6 different Candida spp. were compared, the more inherently fluconazole-resistant isolates adhered more avidly in the following order: C. glabrata [Torulopsis glabrata] > C. krusei > C. albicans fluconazole-sensitive > C. tropicalis > C. parapsilosis. However, fluconazole-resistant C. albicans demonstrated the greatest degree of adherence in comparison to all fluconazole-susceptible C. albicans (P<0.001) and to all Candida spp. tested (P<0.001). It is concluded that the refractoriness of oesophageal candidosis in patients infected with fluconazole-resistant isolates may be related to both in vitro drug resistance and increased mucosal adherence. KW - adhesion KW - antifungal agents KW - antifungal properties KW - candidosis KW - drug resistance KW - fluconazole KW - in vitro KW - physiology KW - susceptibility KW - testing KW - Candida acidothermophilum KW - Candida albicans KW - Candida glabrata KW - Candida parapsilosis KW - Candida tropicalis KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Torulopsis KW - Pezizomycotina KW - anti-fungal properties KW - Candida krusei KW - candidiasis KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticide and Drug Resistance (HH410) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201675&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Body weight and prior depletion affect plasma ascorbate levels attained on identical vitamin C intake: a controlled-diet study. AU - Block, G. AU - Mangels, A. R. AU - Patterson, B. H. AU - Levander, O. A. AU - Norkus, E. P. AU - Taylor, P. R. JO - Journal of the American College of Nutrition JF - Journal of the American College of Nutrition Y1 - 1999/// VL - 18 IS - 6 SP - 628 EP - 637 SN - 0731-5724 AD - Block, G.: National Cancer Institute, Bethesda, USA. N1 - Accession Number: 20001410219. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - The aim of the study was to evaluate the role of factors that may affect the level of plasma ascorbic acid (AA), including age, body weight, physical activity, minor illness and the impact of prior depletion and repletion. After 1 month of stabilization on 60 mg AA/day, subjects underwent 2 complete depletion-repletion cycles (one cycle=one month of AA depletion with 9 mg/day, followed by 1 month of repletion with 117 mg/day). Subjects (68 men, aged 30 to 59 years) did not smoke or drink alcohol during the study. All food was provided by the study. There was extreme individual variability in the plasma AA level achieved on an identical repletion dose: after 4 weeks at 117 mg/day of AA, AA ranged from 26.8 to 85.8 µmol/litre. Body weight was inversely associated with plasma AA attained (p<0.0001). Regression analysis indicated that, compared to a 130-lb man, a 200-lb man reached 10 µmol/litre lower AA after the first repletion and 18 µmol/litre lower AA after the second repletion. One-third of the subjects did not reach a plasma plateaux after the first repletion. Prior depletion and apparent repletion also had a major impact, and only 10% of subjects reached the same plasma AA on the second repletion as on the first repletion. It is concluded that plasma AA attained on a given dose depends on body weight (or dose per kg of body weight) and on whether or not any prior depletions had been repleted adequately. The results have implications for nutrition recommendations and research design. KW - age KW - ascorbic acid KW - blood KW - blood chemistry KW - body weight KW - depletion KW - diet KW - men KW - physical activity KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410219&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Amphotericin B lipid complex in pediatric patients with invasive fungal infections. AU - Walsh, T. J. AU - Seibel, N. L. AU - Arndt, C. AU - Harris, R. E. AU - Dinubile, M. J. AU - Reboli, A. AU - Hiemenz, J. AU - Chanock, S. J. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1999/// VL - 18 IS - 8 SP - 702 EP - 708 SN - 0891-3668 AD - Walsh, T. J.: Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19991202620. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The safety and antifungal efficacy of amphotericin B lipid complex (ABLC, Abelcet) in 111 treatment episodes in paediatric patients were evaluated in an open label, emergency use multicentre study in the USA. Patients with invasive fungal infections were enrolled if they had mycoses refractory to conventional antifungal therapy, if they were intolerant of previous systemic antifungal agents or concomitant nephrotoxic drugs or if they had pre-existing renal disease. All 111 treatment episodes were evaluable for safety and 54 were evaluable for efficacy. The mean serum creatinine for the study population did not significantly change between baseline (1.23±0.11 mg/dl) and cessation of ABLC therapy (1.32±0.12 mg/dl) during 6 weeks. There were no significant differences observed between initial and end-of-therapy levels of serum potassium, magnesium, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and haemoglobin. However, there was an increase in mean total bilirubin (3.66±0.73 to 5.31±1.09 mg/dl) at the end of therapy (P=0.054). Among 54 cases fulfilling criteria for evaluation of antifungal efficacy, a complete or partial therapeutic response was obtained in 38 patients (70%) after ABLC therapy. Complete or partial therapeutic response was documented in 56% of cases with Aspergillus infection (n=25) and in 81% (n=27) with Candida infection. Among premature infants (n=8) and allogeneic marrow recipients (n=14), response rates were 88 and 57%, respectively. The response was similar in those patients enrolled due to intolerance to previous antifungal therapy or because of progressive infection. It is concluded that these results support the use of ABLC for the treatment of invasive fungal infections in paediatric patients who are intolerant or refractive to conventional antifungal therapy. KW - amphotericin B KW - antifungal agents KW - application methods KW - aspergillosis KW - candidosis KW - children KW - drug formulations KW - drug therapy KW - efficacy KW - human diseases KW - infections KW - lipids KW - mycoses KW - safety KW - USA KW - Aspergillus KW - Candida KW - fungi KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - candidiasis KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - lipins KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202620&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lyme disease vaccine. AU - Gerber, M. A. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1999/// VL - 18 IS - 9 SP - 825 EP - 826 SN - 0891-3668 AD - Gerber, M. A.: National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 20000502837. Publication Type: Journal Article. Language: English. Number of References: 10 ref. KW - human diseases KW - Lyme disease KW - vaccines KW - Borrelia burgdorferi KW - man KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - lyme borreliosis KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000502837&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low incidence of human papillomavirus type 16 antibody seroconversion in young children. AU - Manns, A. AU - Strickler, H. D. AU - Wiktor, S. Z. AU - Pate, E. J. AU - Gray, R. AU - Waters, D. JO - Pediatric Infectious Disease Journal JF - Pediatric Infectious Disease Journal Y1 - 1999/// VL - 18 IS - 9 SP - 833 EP - 835 SN - 0891-3668 AD - Manns, A.: National Cancer Institute, 6120 Executive Blvd., Room 8008, MSC 7248, Rockville, MD 20852, USA. N1 - Accession Number: 20002007686. Publication Type: Journal Article. Language: English. Number of References: 11 ref. KW - antibodies KW - disease transmission KW - human diseases KW - infants KW - neonates KW - seroconversion KW - Jamaica KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Papillomaviridae KW - human papillomavirus KW - newborn infants KW - Papovaviridae KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007686&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Responsiveness of selenoproteins to dietary selenium. AU - Allan, C. B. AU - Lacourciere, G. M. AU - Stadtman, T. C. JO - Annual Review of Nutrition JF - Annual Review of Nutrition Y1 - 1999/// VL - 19 SP - 1 EP - 16 SN - 0199-9885 AD - Allan, C. B.: NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991414994. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition N2 - A review. KW - diets KW - intake KW - reviews KW - selenium KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - selenoproteins KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414994&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS. AU - Shearer, G. M. AU - Pinto, L. A. AU - Clerici, M. JO - Immunology Today JF - Immunology Today Y1 - 1999/// VL - 20 IS - 2 SP - 66 EP - 71 SN - 0167-4919 AD - Shearer, G. M.: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992005055. Publication Type: Journal Article. Language: English. Number of References: 49 ref. KW - acquired immune deficiency syndrome KW - disease prevention KW - HIV infections KW - immunization KW - immunotherapy KW - reviews KW - vaccines KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - alloimmunization KW - human immunodeficiency virus infections KW - immune sensitization KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Relationship between event rates and treatment effects in clinical site differences within multicenter trials: an example from primary Pneumocystis carinii prophylaxis. AU - Ioannidis, J. P. A. AU - Dixon, D. O. AU - McIntosh, M. AU - Albert, J. M. AU - Bozzette, S. A. AU - Schnittman, S. M. JO - Controlled Clinical Trials JF - Controlled Clinical Trials Y1 - 1999/// VL - 20 IS - 3 SP - 253 EP - 266 SN - 0197-2456 AD - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 19991202425. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 80-08-0, 100-33-4, 140-64-7. Subject Subsets: Medical & Veterinary Mycology N2 - A diagnostic approach for evaluating the diversity observed in results of multicentre clinical trials, that emphasizes the relationship between the observed event rates and treatment effects, is presented. As an example, a trial of sequential strategies of Pneumocystis prophylaxis in HIV infection with 842 patients randomly allocated to start prophylaxis with trimethoprim/sulfamethoxazole, dapsone or pentamidine, is used. Prophylaxis failure rates varied significantly across the 30 clinical sites (0-30.3%; P=0.002 by Fisher's exact test) with prominent variability in the pentamidine arm (0-63.6%). Starting with oral regimens was better than starting with pentamidine in sites with high rates of events, whereas the 3 strategies had more similar efficacy in other sites. Sites enrolling fewer patients had lower event rates and had more patients who withdrew prematurely or were lost to follow-up. In a hierarchical regression model adjusting for random measurement error in the observed event rates, starting with trimethoprim/sulfamethoxazole was predicted to be increasingly better than starting with aerosolized pentamidine as the risk of prophylaxis failure increased (P=0.01), reducing the risk of failure by 47% when the failure rate of pentamidine was 30%, whereas the 2 regimens were predicted to be equivalent when the failure rate was 17%. Differences in event rates could reflect a combination of heterogeneity in diagnosis, administration of treatments, and disease risk in patients across sites. It is suggested that the evaluation of clinical site differences with a systematic approach focusing on event rates may give further insight in the interpretation of the results of multicentre trials beyond an average treatment effect. KW - aerosols KW - clinical aspects KW - clinical trials KW - dapsone KW - disease prevention KW - drug therapy KW - efficacy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - mycoses KW - opportunistic infections KW - pentamidine KW - pneumocystosis KW - prophylaxis KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - chemotherapy KW - clinical picture KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - sulfamethoxazole trimethoprim KW - trimethoprim sulfamethoxazole KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202425&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cervical dysplasia on cervicovaginal Papanicolaou smear among HIV-1-infected pregnant and nonpregnant women. AU - Stratton, P. AU - Prabodh Gupta AU - Riester, K. AU - Fox, H. AU - Zorrilla, C. AU - Tuomala, R. AU - Eriksen, N. AU - Vajaranant, M. AU - Minkoff, H. AU - Fowler, M. G. JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology Y1 - 1999/// VL - 20 IS - 3 SP - 300 EP - 307 AD - Stratton, P.: National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 19992004098. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - The association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors were studied in the USA. Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV-infected women were evaluated. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17% and 23.8%, respectively; P=0.09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95% confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95% CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95% CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). It is concluded that Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted. KW - cervical cancer KW - cervix KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lesions KW - neoplasms KW - pregnancy KW - women KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - gestation KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004098&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) retards mammary gland involution in lactating Sprague-Dawley rats. AU - Venugopal, M. AU - Callaway, A. AU - Snyderwine, E. G. JO - Carcinogenesis JF - Carcinogenesis Y1 - 1999/// VL - 20 IS - 7 SP - 1309 EP - 1314 SN - 0143-3334 AD - Venugopal, M.: Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 20001408440. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9002-62-4. Subject Subsets: Human Nutrition; Dairy Science N2 - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic nitrogen compound from cooked meat, is an established mammary gland carcinogen in female rats. Four doses of PhIP (150 mg/kg, p.o., once per day) were given to lactating Sprague-Dawley rats separated from their 10-day-old pups to initiate involution of the gland. 24 h after the last dose, apoptotic index in the mammary gland, as measured by the TUNEL assay, was higher in the gland from control rats than in the PhIP-treated rats (4.757±1.066 versus 1.905±0.248%; P<0.05). In comparison with controls, alveoli in the mammary gland of PhIP-treated rats were also visibly larger and contained more secretory epithelial cells. The expression of Bax, a stimulator of apoptosis, and Bcl-2, an inhibitor of apoptosis, were quantitated by western blotting. Accordingly, Bax expression was 2.7-fold higher in control rats, whereas Bcl-2 expression was 3.1-fold higher in PhIP-treated rats (Student's t-test, P<0.05). Immunohistochemistry further confirmed a lower expression of Bax and higher expression of Bcl-2 in secretory alveolar epithelial cells of the PhIP-treated mammary gland. The findings are consistent with the notion that exposure to PhIP retarded involution via partial inhibition of programmed cell death. To investigate possible mechanisms for the inhibitory effects of PhIP on mammary gland involution, serum levels of prolactin, an important hormone for the maintenance of lactation, were measured in virgin rats with regular oestrous cycles given PhIP (150 mg/kg, p.o.) on the morning of dioestrous. After one oestrous cycle, on pro-oestrous morning, serum prolactin levels were 1.3-fold higher after PhIP than after control vehicle (one-way ANOVA, Fisher LSD multiple comparison test, P<0.05). PhIP exposure during involution was associated with the induction of benign mammary tumours. Seven out of 12 rats developed fibroadenomas, and one developed a tubulo-papillary carcinoma within 1 year of receiving PhIP administration during involution (150 mg/kg, p.o., once per day for 5 days), and a high-fat diet (23.5% maize oil). An increase in serum prolactin level and the effects on mammary gland apoptosis seen with PhIP may have implications for the mechanisms of carcinogenic targeting of PhIP to the mammary gland. KW - apoptosis KW - carcinogenesis KW - carcinoma KW - heterocyclic nitrogen compounds KW - inhibition KW - involution KW - lactation KW - mammary glands KW - neoplasms KW - oestrous cycle KW - prolactin KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - breeding cycle KW - cancers KW - estrous cycle KW - lactogenic hormone KW - mammotropin KW - reproductive cycle KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001408440&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. AU - Salomon, D. S. AU - Bianco, C. AU - Santis, M. de JO - BioEssays JF - BioEssays Y1 - 1999/// VL - 21 IS - 1 SP - 61 EP - 70 SN - 0265-9247 AD - Salomon, D. S.: Tumor Factor Growth Section, LTIB, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990401521. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Dairy Science N2 - This review covers EGF (epidermal growth factor)-like growth factors in mammary gland development, EGF-like growth factors in mammary gland transformation and tumorigenesis, Cripto-1, a novel EGF-related protein, Cripto-1 expression, physicochemical properties of native and recombinant Cripto-1, Cripto-1 receptor and downstream signalling, Cripto-1 in mouse (Cr-1) and human (CR-1) mammary epithelial cells and Cripto-1 expression in human breast cancer cell lines and breast tumours. In the mouse, Cr-1 is expressed in the growing terminal end buds in the virgin mouse mammary gland and expression increases during pregnancy and lactation. Cr-1/CR-1 is overexpressed in mouse and human mammary tumours and inappropriate overexpression of Cr-1 in mouse mammary epithelial cells can lead to the clonal expansion of ductal hyperplasia. It is suggested that Cr-1/CR-1 performs a role in normal mammary gland development and that it might contribute to the early stages of mouse mammary tumorigenesis and the pathobiology of human breast cancer. KW - breast KW - breast cancer KW - epidermal growth factor KW - gene expression KW - growth factors KW - lactation KW - mammary development KW - mammary gland neoplasms KW - mammary glands KW - milk proteins KW - neoplasms KW - pregnancy KW - receptors KW - recombinant proteins KW - reviews KW - women KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - breasts KW - cancers KW - gestation KW - mammary tumour KW - Milk and Dairy Produce (QQ010) KW - General Physiology (ZZ340) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Laboratory Animal Science (LL040) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990401521&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The effects of reducing sodium and increasing potassium intake for control of hypertension and improving health. AU - Cutler, J. A. A2 - Chalmers, J. JO - Clinical and Experimental Hypertension JF - Clinical and Experimental Hypertension Y1 - 1999/// VL - 21 IS - 5/6 SP - 769 EP - 783 AD - Cutler, J. A.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20001412278. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 36 ref. Registry Number: 7440-09-7, 7440-23-5. Subject Subsets: Human Nutrition N2 - A review. From a world-wide, population perspective, the problem of excessive blood pressure levels for optimal cardiovascular health is immense and growing. Evidence from animal experimentation, observational epidemiology, and randomized clinical trials strongly support efforts to change nutritional factors in desirable directions, especially to lower dietary salt and increase potassium intake. KW - blood pressure KW - cardiovascular diseases KW - cardiovascular system KW - control KW - diets KW - epidemiology KW - health KW - hypertension KW - nutrition KW - potassium KW - reviews KW - salt KW - sodium KW - circulatory system KW - high blood pressure KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412278&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A multicenter, randomized, controlled trial of three preparations of low-dose oral α-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm³. AU - Alston, B. AU - Ellenberg, J. H. AU - Standiford, H. C. AU - Muth, K. AU - Martinez, A. AU - Greaves, W. AU - Kumi, J. JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes Y1 - 1999/// VL - 22 IS - 4 SP - 348 EP - 357 AD - Alston, B.: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7624, USA. N1 - Accession Number: 20002009489. Publication Type: Journal Article. Corporate Author: USA, Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group Language: English. Number of References: 18 ref. Registry Number: 9008-11-1. Subject Subsets: Public Health N2 - The effectiveness of low-dose oral α-interferon (α-IFN) was evaluated in 247 human immunodeficiency virus (HIV)-infected study subjects who received placebo, Alferon LDO, Veldona, or Ferimmune in a randomized, double-blind trial conducted in the USA between April 1996 and July 1997. Subjects had CD4+ counts between 50 and 350 cells/mm³and HIV-related symptoms at entry. Study subjects rated the severity of 8 symptoms using a symptom burden index (SBI). Study endpoints included changes in SBI, weight, CD4+ count and Karnofsky score between baseline and the 24-week visit. The SBI outcome and weight were measured in 99 and 106 study subjects, respectively, at both the baseline and 24-week visits. Baseline SBI scores ranged from 5.4 to 7.9 in the 4 arms. No clinically important or statistically significant differences were found among the 4 arms with regard to SBI or weight change over the 24-week period. There were also no significant differences among the arms for CD4+ cell count and Karnofsky score. Few adverse reactions were noted in any arm, and there were no significant differences between arms. Although the trial was designed to enrol 560 study subjects and was prematurely terminated because of slow accrual and discontinuations of participants, it is concluded that the small differences among the arms in the primary and secondary endpoints do not support claims of efficacy for the measures studied. KW - adverse effects KW - antiviral agents KW - CD4+ lymphocytes KW - drug formulations KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interferon KW - symptoms KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - CD4+ cells KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - T4 lymphocytes KW - United States of America KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Pesticides and Drugs; Control (HH405) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009489&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects. AU - Weyer, C. AU - Snitker, S. AU - Rising, R. AU - Bogardus, C. AU - Ravussin, E. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1999/// VL - 23 IS - 7 SP - 715 EP - 722 SN - 0307-0565 AD - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19991411277. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition N2 - The aims of the study were to provide comprehensive prediction equations for 24 h energy expenditure (24-EE), sleeping metabolic rate (SMR) and 24 h respiratory quotient (24-RQ), based on a large number of Caucasian and Pima Indian subjects, covering a wide range of body weight and composition, body fat distribution, and age; and to test whether Pima Indians have lower metabolic rate and/or higher 24-RQ than Caucasians. 916 non-diabetic subjects (561 males, 355 females; 416 Caucasians, 500 Pima Indians; 720 with normal (NGT) and 196 with impaired (IGT) glucose tolerance), aged 31.5±11.9 years, body weight 90.5±26.1 kg (mean±s.d.), spent 24 h in a respiratory chamber for measurements of 24-EE, SMR and 24-RQ. Fat-free mass (FFM) and fat mass (FM) were assessed by either hydrodensitometry or dual energy X-ray absorptiometry (DEXA). Waist circumference and waist-to-thigh ratio (WTR) were determined as measures of body fat distribution. In a stepwise multiple regression analysis, FFM, FM, sex, age, WTR, and ethnicity were significant independent determinants of 24-EE (2258±422 kcal/day), explaining 85% of its variability (24-EE (kcal/day)= 696 + 18.9 FFM (kg) + 10.0 FM (kg) + 180 male-1.9 age + 7.1 WTR + 44 Pima Indian). SMR (1623±315 kcal/day) was determined (78% of variability) by FFM, FM, sex, age, WTR, and glucose tolerance (SMR (kcal/day)=443 + 14.6 FFM (kg) + 6.9 FM (kg) + 79 male-1.0 age + 5.8 WTR + 38 IGT), but not by ethnicity. Adjustment for the respective variables reduced the variance in 24-EE from 422 to 162 kcal/day and in SMR from 315 to 146 kcal/day. 24-RQ (0.854±0.026) was determined by waist circumference and energy balance (24-RQ=0.88429-0.00175 waist circumference + 0.00004 energy balance (%)), but not by sex, ethnicity or glucose tolerance. With this equation only 13% of the variability in 24-RQ could be explained (residual variance 0.024). Compared to Caucasians, Pima Indians had higher 24-EE, but similar SMR and 24-RQ. It is concluded that this analysis provides comprehensive prediction equations for 24-EE, SMR and 24-RQ from their major known determinants. It confirms the previous findings that, even after adjustment for body composition, age, sex, ethnicity, and glucose tolerance, there is still considerable variability in energy expenditure and substrate oxidation that may, in part, be genetically determined. In adult Pima Indians, no evidence for lower metabolic rate or impaired fat oxidation that could explain the propensity towards obesity in this ethnic group was found. KW - age KW - American indians KW - basal metabolism KW - body composition KW - body weight KW - energy KW - energy metabolism KW - ethnic groups KW - ethnicity KW - genetics KW - glucose tolerance KW - obesity KW - resting energy exchange KW - sex differences KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - basal energy exchange KW - blood sugar tolerance KW - ethnic differences KW - fatness KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411277&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Overweight prevalence among youth in the United States: why so many different numbers? AU - Troiano, R. P. AU - Flegal, K. M. JO - International Journal of Obesity JF - International Journal of Obesity Y1 - 1999/// VL - 23 SP - S22 EP - S27 SN - 0307-0565 AD - Troiano, R. P.: Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19991406467. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Subject Subsets: Human Nutrition N2 - The variety and evolution among youth in the US are discussed. Issues of definition, measurements, criteria selection and comparison groups are considered and implications from estimates of the prevalance of overweight among youth are explored. Reference percentiles for body mass index from several publications are compared. KW - adolescents KW - analytical methods KW - anthropometric dimensions KW - body composition KW - body weight KW - children KW - guidelines KW - height KW - obesity KW - overweight KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - analytical techniques KW - anthropometric measurements KW - fatness KW - prevalence KW - recommendations KW - teenagers KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991406467&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Early infection in bone marrow transplantation: quantitative study of clinical factors that affect risk. AU - Engels, E. A. AU - Ellis, C. A. AU - Supran, S. E. AU - Schmid, C. H. AU - Barza, M. AU - Schenkein, D. P. AU - Koc, Y. AU - Miller, K. B. AU - Wong, J. B. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 28 IS - 2 SP - 256 EP - 266 SN - 1058-4838 AD - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Boulevard, EPN 434, Rockville, Maryland 20822, USA. N1 - Accession Number: 19992003966. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Public Health N2 - To examine clinical factors that affect infection risk, patients who received bone marrow transplants (53 autologous and 51 allogeneic) at New England Medical Center, Boston, USA were retrospectively studied. Over a median of 27 hospital days, 44 patients developed documented infections. Both autologous transplantation and haematopoietic growth factor use were associated with less prolonged neutropenia and decreased occurrence of infection (P≤0.05). In a survival regression model, variables independently associated with infection risk were the log10 of the neutrophil count (hazard ratio [HR], 0.49; 95% confidence interval [CI], 0.32-0.75), ciprofloxacin prophylaxis (HR, 0.42; 95% CI, 0.19-0.95), empirical intravenous antibiotic use (HR, 0.09; 95% CI, 0.03-0.32), and an interaction between neutrophil count and intravenous antibiotic use (HR, 1.86; 95% CI, 1.06-3.29). In this model, infection risk increases steeply at low neutrophil counts for patients receiving no antibiotic therapy. Ciprofloxacin prophylaxis and particularly intravenous antibiotic therapy provide substantial protection at low neutrophil counts. These results can be used to model management strategies for transplant recipients. KW - bone marrow transplant KW - clinical aspects KW - human diseases KW - immunocompromised hosts KW - opportunistic infections KW - risk factors KW - transplant recipients KW - Massachusetts KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - New England States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - recipients KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003966&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Treatment of hydrocephalus secondary to cryptococcal meningitis by use of shunting. AU - Park, M. K. AU - Hospenthal, D. R. AU - Bennett, J. E. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 28 IS - 3 SP - 629 EP - 633 SN - 1058-4838 AD - Park, M. K.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991201428. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The clinical courses of 10 non-HIV-infected patients (7 men, 3 women; aged 17-66 years) from the USA, with hydrocephalus secondary to cryptococcal meningitis who underwent shunting procedures during 1967--95, were reviewed. Of these 10 patients who underwent shunting, 9 had noticeable improvement in dementia and gait. Two patients required late revision of their shunts. Shunt placement in 8 patients with acute infection did not disseminate cryptococcal infection into the peritoneum or bloodstream, nor did shunting provide a nidus from which Cryptococcus neoformans organisms proved difficult to eradicate. It is concluded that shunting procedures are a safe and effective therapy for hydrocephalus in patients with cryptococcal meningitis and need not be delayed until patients are mycologically cured. KW - central nervous system KW - clinical aspects KW - complications KW - cryptococcal meningitis KW - cryptococcosis KW - human diseases KW - hydrocephalus KW - infections KW - meningitis KW - treatment KW - USA KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - clinical picture KW - CNS KW - european blastomycosis KW - fungus KW - meningeal cryptococcosis KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201428&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Guide to major clinical trials of antiretroviral therapy in human immunodeficiency virus-infected patients: protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and nucleotide reverse transcriptase inhibitors. AU - Tavel, J. A. AU - Miller, K. D. AU - Masur, H. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 28 IS - 3 SP - 643 EP - 676 SN - 1058-4838 AD - Tavel, J. A.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 115231, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19992007261. Publication Type: Journal Article. Language: English. Number of References: 99 ref. Subject Subsets: Public Health N2 - This review summarizes, in table format, studies that have shaped the principals of antiretroviral therapy, particularly clinical endpoint trials, proof-of-concept trials that have influenced the standard of care for human immunodeficiency virus treatment, double-blind, randomized trials and large trials with long-term patient follow-up. Smaller trials that address important questions are also included. KW - clinical trials KW - drug therapy KW - enzyme inhibitors KW - human diseases KW - human immunodeficiency viruses KW - proteinase inhibitors KW - reverse transcriptase inhibitors KW - reviews KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - nucleotide reverse transcriptase inhibitors KW - protease inhibitors KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007261&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Predictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawi. AU - Ioannidis, J. P. A. AU - Taha, T. E. AU - Kumwenda, N. AU - Broadhead, R. AU - Mtimavalye, L. AU - Miotti, P. AU - Yellin, F. AU - Contopoulos-Ioannidis, D. G. AU - Biggar, R. J. JO - International Journal of Epidemiology JF - International Journal of Epidemiology Y1 - 1999/// VL - 28 IS - 4 SP - 769 EP - 775 SN - 0300-5771 AD - Ioannidis, J. P. A.: HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. N1 - Accession Number: 20002007904. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 56-95-1, 18472-51-0, 3697-42-5, 55-56-1. N2 - Predictors and the impact of losses to follow-up of infants born in a large cohort of delivering women in urban Malawi during June-November 1994, were studied. The cohort was established as part of a trial of vaginal cleaning with chlorhexidine during delivery to prevent mother-to-infant transmission of HIV. The HIV infection status could not be determined for 797 (36.9%) of 2156 infants born to HIV-infected mothers; 144 (6.7%) with missing status because of various sample problems and 653 (30.3%) because they never returned to the clinic. Notably, the observed rates of perinatal transmission were significantly lower in infants who returned later for determination of their infection status (odds ratio =0.94 per month, P=0.03), even though these infants must have had an additional risk of infection from breastfeeding. In multivariate models, infants of lower birthweight (P=0.003) and, marginally, singletons (P=0.09) were less likely to return for follow-up. The parents of infants lost to follow-up tended to be less educated (P>0.001) and more likely to be in farming occupations, although one educated group, teachers and students, were also significantly less likely to return. Of these variables, infant birthweight, twins versus singletons, and maternal education were also associated with significant variation in the observed risk of perinatal transmission among infants of known HIV status. Several predictors of loss to follow-up were identified in this large HIV perinatal cohort. Losses to follow-up can impact the observed transmission rate and the risk associations in different studies. KW - birth weight KW - breast feeding KW - children KW - chlorhexidine KW - disease transmission KW - education KW - epidemiology KW - follow up KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - maternal transmission KW - mothers KW - neonates KW - occupations KW - urban areas KW - vagina KW - viral diseases KW - women KW - Africa KW - Malawi KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - newborn infants KW - Nyasaland KW - viral infections KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Women (UU500) KW - Human Sexual and Reproductive Health (VV065) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007904&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Similarities between the pathogenesis of and immunity to diphtheria and pertussis: the complex nature of serum antitoxin - induced immunity to these two diseases. AU - Schneerson, R. A2 - Cherry, J. D. A2 - Robbins, J. B. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 28 SP - S136 EP - S139 SN - 1058-4838 AD - Schneerson, R.: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Building 6, Room 424, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19992011669. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 62 ref. Registry Number: 308067-58-5. N2 - Similarities between the pathogenesis and immunity to pertussis and diphtheria are examined. As with pertussis, diphtheria toxoid vaccination confers only ~70% immunity on an individual basis, individuals with protective levels of antitoxin may contract diphtheria, and about 50% of the entire population, especially adults, have less than protective levels of antitoxin. The virtual disappearance of diphtheria followed vaccination of the entire population with diphtheria toxoid, which blocked transmission of toxigenic Corynebacterium diphtheriae and thus reduced the pathogen to almost undetectable levels. It is suggested that the individual and community-based immunity induced by diphtheria toxoid is similar to that of pertussis and pertussis toxoid. KW - antibodies KW - antitoxins KW - clinical aspects KW - diphtheria KW - human diseases KW - IgG KW - immunity KW - pathogenesis KW - pertussis KW - reviews KW - toxoids KW - vaccination KW - Corynebacterium diphtheriae KW - man KW - Corynebacterium KW - Corynebacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - clinical picture KW - whooping cough KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011669&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin A deficiency and other nutritional indices during pregnancy in human immunodeficiency virus infection: prevalence, clinical correlates, and outcome. AU - Burns, D. N. AU - FitzGerald, G. AU - Semba, R. AU - Hershow, R. AU - Zorrilla, C. AU - Pitt, J. AU - Hammill, H. AU - Cooper, E. R. AU - Fowler, M. G. AU - Landesman, S. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 29 IS - 2 SP - 328 EP - 334 SN - 1058-4838 AD - Burns, D. N.: Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 20002007127. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - Vitamin A levels in plasma and other nutritional indices were measured during pregnancy for 449 women from the USA, enrolled in a multicentre cohort study of mother-to-infant transmission of human immunodeficiency virus type 1 (HIV-1). During the third trimester, 29.6% of the women had low (20 to <30 µg/dl) and 11.1% had very low (<20 µg/dl) vitamin A levels. Vitamin A and body mass index, serum albumin levels, and haemoglobin levels were weakly correlated. After adjustment for other covariates, women with low and very low vitamin A levels before the third trimester were more likely to deliver infants with low birth weight (<2500 g) than were those with higher levels (odds ratio (OR), 4.58; 95% confidence interval (CI), 1.57-13.4; and OR, 6.99; 95% CI, 1.09-45.0, respectively). However, there was no statistically significant association between vitamin A level and mother-to-infant transmission of HIV-1. Anaemia and low body mass index before the third trimester were associated with an increased risk of transmission in univariate analyses but not in multivariate analyses. KW - albumins KW - anaemia KW - birth weight KW - blood plasma KW - clinical aspects KW - deficiency KW - disease transmission KW - haemoglobin KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - infants KW - low birth weight infants KW - maternal transmission KW - nutrition KW - pregnancy KW - retinol KW - serum albumin KW - viral diseases KW - women KW - USA KW - Human immunodeficiency virus 1 KW - man KW - viruses KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - anemia KW - axerophthol KW - clinical picture KW - gestation KW - hemoglobin KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - plasma (blood) KW - United States of America KW - viral infections KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Women (UU500) KW - Human Nutrition (General) (VV100) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007127&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. AU - Klion, A. D. AU - Horton, J. AU - Nutman, T. B. JO - Clinical Infectious Diseases JF - Clinical Infectious Diseases Y1 - 1999/// VL - 29 IS - 3 SP - 680 EP - 682 SN - 1058-4838 AD - Klion, A. D.: Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20000804143. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 54965-21-8, 90-89-1, 1642-54-2. Subject Subsets: Helminthology; Tropical Diseases N2 - Three patients who had symptomatic loiasis refractory to more than 4 courses of diethylcarbamazine were treated orally with albendazole at 200 mg twice-daily for 21 days. At the time of treatment, all patients had persistent symptoms despite decreasing titres of antifilarial antibodies and normal eosinophil counts. Symptoms resolved in all 3 patients following albendazole therapy. In one patient, nonspecific symptoms recurred 2 years later but, unlike her symptoms before albendazole therapy, were not accompanied by the appearance of subcutaneous nodules containing adult worms. The other 2 patients remained symptom-free over 8 years of follow-up. Albendazole may be useful for the treatment of loiasis in cases when diethylcarbamazine is ineffective or cannot be used. All the patients were USA residents who had acquired Loa loa infections during temporary residence in Gabon. KW - albendazole KW - anthelmintics KW - diethylcarbamazine KW - drug therapy KW - helminths KW - human diseases KW - imported infections KW - loiasis KW - nematode infections KW - parasites KW - treatment failure KW - Gabon KW - USA KW - Loa loa KW - man KW - Loa KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - ACP Countries KW - Central Africa KW - Africa South of Sahara KW - Africa KW - Developing Countries KW - Francophone Africa KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - African eyeworm KW - chemotherapy KW - loaosis KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804143&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of surface molecules on salivary glands of the mosquito, Aedes aegypti, by a panel of monoclonal antibodies. AU - Barreau, C. AU - Conrad, J. AU - Fischer, E. AU - Lujan, H. D. AU - Vernick, K. D. JO - Insect Biochemistry and Molecular Biology JF - Insect Biochemistry and Molecular Biology Y1 - 1999/// VL - 29 IS - 6 SP - 515 EP - 526 SN - 0965-1748 AD - Barreau, C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990504947. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - Characterization of salivary gland surface molecules of A. aegypti was undertaken to identify candidate receptors for Plasmodium gallinaceum sporozoite invasion. Monoclonal antibodies (MAbs) were generated against antigen enriched for salivary gland membranes and basal lamina. A panel of 44 MAbs were generated that bound to surface molecules of mosquito tissues. 24 MAbs bound exclusively to salivary glands, 6 bound to salivary glands and ovaries, one bound to salivary gland and midgut, and 13 bound to all tissues tested. Data on the immunolocalization and biochemical characteristics of the antigens are presented. Many of the salivary gland-specific MAbs bound preferentially to the median and distal lateral lobes of the salivary glands, indicating that there are anatomical region-specific biochemical differences on the gland surface. These lobes of the salivary glands are the preferential sites of malaria sporozoite invasion. Therefore, antigens specific for these regions are promising candidate receptors for sporozoite invasion. The present identification of surface molecules of mosquito salivary glands by means of monoclonal antibodies represents the first description of individual molecules on the mosquito salivary gland surface. KW - antigens KW - binding sites KW - biochemistry KW - host parasite relationships KW - monoclonal antibodies KW - parasites KW - salivary glands KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - antigenicity KW - binding site KW - immunogens KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504947&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Apoptosis in a canine model of acute chagasic myocarditis. AU - Zhang Jun AU - Andrade, Z. A. AU - Yu ZuXi AU - Andrade, S. G. AU - Takeda, K. AU - Sadirgursky, M. AU - Ferrans, V. J. JO - Journal of Molecular and Cellular Cardiology JF - Journal of Molecular and Cellular Cardiology Y1 - 1999/// VL - 31 IS - 3 SP - 581 EP - 596 AD - Zhang Jun: Pathology Section, National Heart, Lung & Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990808148. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Protozoology N2 - Six dogs were experimentally infected with Trypanosoma cruzi and necropsied 18 days later (considered to be the time of maximum intensity of acute myocarditis), as were 2 uninfected controls. The occurrence of apoptosis in the heart was investigated using confocal microscopy, nick end labelling (to detect the fragmentation of DNA, by 4 different techniques) and electron microscopy. Apoptosis was detected in cardiac myocytes (mainly those not infected by parasites), and in smaller numbers of blood vessel endothelial cells, immune effector cells and parasites. The significance of these findings is discussed. KW - apoptosis KW - Chagas' disease KW - endothelium KW - experimental infections KW - heart diseases KW - host parasite relationships KW - human diseases KW - immune response KW - laboratory animals KW - lymphocytes KW - macrophages KW - myocarditis KW - myocardium KW - parasites KW - pathogenesis KW - pathology KW - dogs KW - protozoa KW - Trypanosoma cruzi KW - Canis KW - Canidae KW - Fissipeda KW - carnivores KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Trypanosoma KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - cardiac muscle KW - coronary diseases KW - heart muscle KW - immunity reactions KW - immunological reactions KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990808148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. AU - Greiner, R. S. AU - Moriguchi, T. AU - Hutton, A. AU - Slotnick, B. M. AU - Salem, N., Jr. JO - Lipids JF - Lipids Y1 - 1999/// VL - 34 SP - S239 EP - S243 SN - 0024-4201 AD - Greiner, R. S.: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Division on Intramural Clinical and Biological Research, Rockville, Maryland, USA. N1 - Accession Number: 19991413055. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 25167-62-8. Subject Subsets: Human Nutrition KW - brain KW - docosahexaenoic acid KW - learning ability KW - mental ability KW - performance KW - smell KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - intelligence KW - learning capacity KW - olfaction KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. AU - Kim HeeYong AU - Edsall, L. JO - Lipids JF - Lipids Y1 - 1999/// VL - 34 SP - S249 EP - S250 SN - 0024-4201 AD - Kim HeeYong: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA. N1 - Accession Number: 19991413058. Publication Type: Journal Article. Language: English. Number of References: 1 ref. Registry Number: 25167-62-8. Subject Subsets: Human Nutrition KW - docosahexaenoic acid KW - nervous system KW - neurons KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - nerve cells KW - neurones KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. AU - Plouzek, C. A. AU - Ciolino, H. P. AU - Clarke, R. AU - Yeh, G. C. JO - European Journal of Cancer JF - European Journal of Cancer Y1 - 1999/// VL - 35 IS - 10 SP - 1541 EP - 1545 SN - 0959-8049 AD - Plouzek, C. A.: Cellular Defense and Carcinogenesis Section, Basic Research Laboratory, Division of Basic Science, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21701, USA. N1 - Accession Number: 19990312381. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - The transmembrane transport pump P-glycoprotein (Pgp) causes the efflux of chemotherapeutic agents from cells and is believed to be an important mechanism in multidrug resistance (MDR) in mammary tumours. An extract of Rosmarinus officinalis increased the intracellular accumulation of commonly used chemotherapeutic agents, including doxorubicin (DOX) and vinblastine (VIN), in drug-resistant MCF-7 human breast cancer cells which express Pgp. The extract inhibited the efflux of DOX and VIN (known to be substrates of Pgp) but did not affect accumulation or efflux of DOX in wild type MCF-7 cells, which lack Pgp. Treatment of drug-resistant cells with the extract increased their sensitivity to DOX, which was consistent with an increased intracellular accumulation of the drug. The extract blocked the binding of the VIN analogue azidopine to Pgp. KW - cell lines KW - cell membranes KW - cytotoxicity KW - drug interactions KW - efflux KW - in vitro KW - medicinal plants KW - neoplasms KW - plant extracts KW - rosemary KW - tumours KW - man KW - Rosmarinus officinalis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Rosmarinus KW - Lamiaceae KW - Lamiales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - cancers KW - drug plants KW - medicinal herbs KW - officinal plants KW - tumors KW - Plant Science (General) (FF000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990312381&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mortality among aerial pesticide applicators and flight instructors: follow-up from 1965-1988. AU - Cantor, K. P. AU - Silberman, W. JO - American Journal of Industrial Medicine JF - American Journal of Industrial Medicine Y1 - 1999/// VL - 36 IS - 2 SP - 239 EP - 247 SN - 0271-3586 AD - Cantor, K. P.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS-8106, Bethesda, MD 20892-7240, USA. N1 - Accession Number: 20001107289. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Agricultural Entomology; Weeds; Nematology; Plant Pathology N2 - Vital status follow-up for a retrospective cohort mortality study of 9961 male aerial pesticide applicators was extended beyond a previous study (1965-1979), through 31 December, 1988. Rate ratios (RR) were used to compare directly adjusted mortality rates between applicators and a comparison cohort of 9969 flight instructors. Standardized mortality ratios (SMR) were calculated for comparisons with the USA white male population. Among applicator pilots, there were 1441 deaths, and among instructors, 1045. In both groups, aircraft accidents were the major cause of death (446 applicators; 234 instructors). Compared with flight instructors, aerial applicator pilots were at significantly elevated risk for all causes of death (risk ratio=1.34) and for malignant neoplasms (1.18), non-motor vehicle accidents (1.71), motor vehicle accidents (1.69), and stroke (1.91). Pancreatic cancer (2.71) and leukaemia (3.35) were significantly elevated. Applicators were at lower risk of colon cancer (0.51) and multiple myeloma (0.23) mortality. Based on USA rates, the SMR for all causes of death among applicators was 111 and among instructors, 81. Aircraft accidents were a major cause of mortality in both applicator and flight instructor cohorts. Several other causes of death, some possibly related to pesticide exposure, were also elevated among pesticide applicator pilots. KW - accidents KW - aerial application KW - aerial spraying KW - agricultural aviation KW - agricultural entomology KW - aircraft KW - carcinogenesis KW - colon KW - herbicides KW - leukaemia KW - mortality KW - myeloma KW - nematicides KW - nematology KW - neoplasms KW - nontarget effects KW - nontarget organisms KW - occupational hazards KW - pancreas KW - pesticides KW - plant pathology KW - stroke KW - USA KW - arthropods KW - man KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood cancer KW - cancers KW - death rate KW - leucaemia KW - leukemia KW - non-target organisms KW - non-target species KW - nontarget species KW - phytopathology KW - United States of America KW - weedicides KW - weedkillers KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000) KW - Occupational Health and Safety (VV900) KW - Human Toxicology and Poisoning (VV810) (New March 2000) KW - Rural Health (VV550) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001107289&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation of DNA after extraction of RNA to detect the presence of Borrelia burgdorferi and expression of host cellular genes from the same tissue sample. AU - Amemiya, K. AU - Schaefer, H. AU - Pachner, A. R. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1999/// VL - 37 IS - 6 SP - 2087 EP - 2089 SN - 0095-1137 AD - Amemiya, K.: National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990504576. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Medical & Veterinary Entomology N2 - The neuropathogenesis of Lyme disease caused by B. burgdorferi was investigated in a nonhuman primate model. In the past, 2 separate pieces of tissue had to be used when both analysing for the presence of the spirochaete and examining the host response to infection. A procedure was modified to purify DNA from the same sample after the extraction of RNA. The remaining material containing the DNA was precipitated, and residual organic reagent was removed prior to deproteinization and extraction of the DNA. This procedure now allows assaying for the presence of the Lyme microorganism and analysis of the host response in the same tissue preparation. KW - detection KW - DNA KW - genes KW - hosts KW - immune response KW - isolation KW - Lyme disease KW - pathogenesis KW - RNA KW - techniques KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - deoxyribonucleic acid KW - immunity reactions KW - immunological reactions KW - lyme borreliosis KW - ribonucleic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504576&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recurrent bacteremia caused by a "Flexispira"-like organism in a patient with X-linked (Bruton's) agammaglobulinemia. AU - Weir, S. AU - Cuccherini, B. AU - Whitney, A. M. AU - Ray, M. L. AU - MacGregor, J. P. AU - Steigerwalt, A. AU - Daneshvar, M. I. AU - Weyant, R. AU - Wray, B. AU - Steele, J. AU - Strober, W. AU - Gill, V. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1999/// VL - 37 IS - 8 SP - 2439 EP - 2445 SN - 0095-1137 AD - Weir, S.: Microbiology Service, Clinical Pathology Department, W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992010306. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 1403-66-3, 1405-41-0, 64221-86-9. Subject Subsets: Public Health N2 - A patient in the USA with X-linked (Bruton's) agammaglobulinaemia was found to have persistent sepsis with a Helicobacter-like organism despite multiple courses of antibiotics. His periods of sepsis [between 1994 and 1997] were associated with leg swelling thought to be consistent with cellulitis. The organism was fastidious and required a microaerophilic environment containing H2 for growth. Optimal growth was observed at 35 to 37°C on sheep blood, CDC anaerobe, and Bordet-Gengou agars. Serial subcultures every 4 to 5 days were required to maintain viability. The organism was strongly urease positive and showed highest relatedness to Helicobacter-like organisms with the vernacular name "Flexispira rappini" by 16S rRNA gene sequence analysis. Genomic DNA hybridization studies, however, found 24 to 37% relatedness to "F. rappini" and even less to other Helicobacter spp. Although the organism phenotypically resembles "Flexispira" and Helicobacter, it is thought to represent a new taxon. The patient's infection was eventually cleared with a prolonged (5-month) course of intravenous imipenem and gentamicin. KW - bacteraemia KW - case reports KW - gentamicin KW - human diseases KW - imipenem KW - immunocompromised hosts KW - new taxa KW - sepsis KW - taxonomy KW - USA KW - Helicobacter KW - man KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacteremia KW - bacterium KW - Flexispira KW - systematics KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010306&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - An uncommon Helicobacter isolate from blood: evidence of a group of Helicobacter spp. pathogenic in AIDS patients. AU - Weir, S. C. AU - Gibert, C. L. AU - Gordin, F. M. AU - Fischer, S. H. AU - Gill, V. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1999/// VL - 37 IS - 8 SP - 2729 EP - 2733 SN - 0095-1137 AD - Weir, S. C.: Microbiology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19992010440. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health N2 - An unusual Helicobacter sp. was isolated from the blood of a human immunodeficiency virus (HIV)-infected patient in the USA in December 1997. This organism had spiral morphology, with single amphitrichous flagella, and was negative for hippurate hydrolysis, production of urease, and reduction of nitrate. 16S rRNA gene sequence analysis verified that the isolate was a species of Helicobacter, most closely related to an undescribed Helicobacter-like isolate from Vancouver, British Columbia, Canada, and to H. westmeadii, a recently described species from Australia. Both organisms had also been isolated from the blood of HIV-infected patients. These blood isolates, along with H. cinaedi, form a cluster of closely related Helicobacter spp. that may represent an emerging group of pathogens in immunocompromised patients. KW - acquired immune deficiency syndrome KW - case reports KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - pathogenicity KW - ribosomal RNA KW - USA KW - Helicobacter KW - man KW - Helicobacteraceae KW - Campylobacterales KW - Epsilonproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - bacterium KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - rRNA KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Taxonomy and Evolution (ZZ380) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010440&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evaluation of two rapid assays for detection of Clostridium difficile toxin A in stool specimens. AU - Fedorko, D. P. AU - Engler, H. D. AU - O'Shaughnessy, E. M. AU - Williams, E. C. AU - Reichelderfer, C. J. AU - Smith, W. I., Jr. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1999/// VL - 37 IS - 9 SP - 3044 EP - 3047 SN - 0095-1137 AD - Fedorko, D. P.: National Institutes of Health, Microbiology Service, CPD, Building 10, Room 2C385, 10 Center Dr. Msc 1508, Bethesda MD 20892-1508, USA. N1 - Accession Number: 20002006497. Publication Type: Journal Article. Language: English. Number of References: 23 ref. N2 - A total of 654 stool specimens were tested to compare the performance of two assays for rapid detection of toxin A, the Immunocard Toxin A test (Meridian Diagnostics, Inc.) and the Culturette Brand Toxin CD enzyme immunoassay (EIA) (Becton Dickinson Microbiology Systems), with a cytotoxin assay (Cytotoxi Test; Advanced Clinical Diagnostics) and culture on cycloserine-cefoxitin-fructose agar followed by determination of the production of toxins A and B. A chart review was performed for patients whose stool specimens provided positive results on 1 to 3 of the assays. With the "gold standard" of all 4 assays positive or chart review evidence of Clostridium difficile-associated diarrhoea (CDAD), 97 (14.8%) stool specimens were positive by one or more assays and 557 (85.2%) were negative by all methods. Total agreement for all assays was 90.5% (592 of 654). The sensitivity, specificity, positive predictive value, and negative predictive value for toxigenic culture were 94.7, 98.6, 87.1, and 99.5%, respectively, for toxigenic culture; 87.7, 98.6, 86.2, and 98.8%, respectively, for the cytotoxin assay; 71.9, 99.3, 91.1, and 97.3%, respectively, for the Immunocard; and 68.4, 99.1, 88.6, and 96.9%, respectively, for the Culturette EIA. It is concluded that while easy to perform and highly specific, these rapid assays do not appear to be sufficient for accurate diagnosis of CDAD. KW - assays KW - bacterial diseases KW - clinical aspects KW - detection KW - diarrhoea KW - enzyme immunoassay KW - human diseases KW - laboratory diagnosis KW - rapid methods KW - techniques KW - toxins KW - Clostridium difficile KW - man KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterial infections KW - bacterioses KW - bacterium KW - clinical picture KW - diarrhea KW - scouring KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Diagnosis of Human Disease (VV720) (New March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006497&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Combining high risk science with ambitious social and economic goals. AU - Rosenthal, J. P. AU - Beck, D. AU - Amar Bhat AU - Biswas, J. AU - Brady, L. AU - Bridbord, K. AU - Collins, S. AU - Cragg, G. AU - Edwards, J. AU - Fairfield, A. AU - Gottlieb, M. AU - Gschwind, L. A. AU - Hallock, Y. AU - Hawks, R. AU - Hegyeli, R. AU - Johnson, G. AU - Keusch, G. T. AU - Lyons, E. E. AU - Miller, R. AU - Rodman, J. AU - Roskoski, J. AU - Siegel-Causey, D. T3 - Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups JO - Pharmaceutical Biology JF - Pharmaceutical Biology Y1 - 1999/// VL - 37 SP - 6 EP - 21 CY - Lisse; Netherlands PB - Swets & Zeitlinger SN - 1388-0209 AD - Rosenthal, J. P.: Fogarty International Center, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892-2220, USA. N1 - Accession Number: 20003026607. Publication Type: Journal Article. Note: Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups Language: English. Number of References: 52 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Plant Genetic Resources; Plant Breeding; Rural Development; Plant Pathology; Aromatic & Medicinal Plants; Tropical Diseases; Public Health; Agricultural Entomology N2 - The International Cooperative Biodiversity Groups (ICBG) represent an experimental effort supported by 3 agencies of the US Government to integrate research in natural products drug discovery with efforts to build the scientific and economic capacity of developing countries as well as enhance the skills and incentives needed to conserve biological diversity. ICBG groups are unique, public-private collaborations that have been carrying out interdisciplinary research and development projects for up to 7 years in 12 developing countries (Latin America, Africa and Asia). In addition to research on species in 230 plant families and 25 arthropod orders, over 1400 individuals have received technical training, and potential therapies for several parasitic diseases, tuberculosis and crop diseases are in development. The ICBGs have also developed novel research and intellectual property agreements and have become important testing grounds in national and global discussions regarding access, informed consent and benefit-sharing associated with genetic resources. KW - conservation KW - economic development KW - genetic resources KW - intellectual property rights KW - natural products KW - phytochemicals KW - plant genetic resources KW - training KW - tuberculosis KW - Africa KW - Asia KW - Latin America KW - USA KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - gene resources KW - United States of America KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Biological Resources (Animal) (PP710) KW - Biological Resources (Plant) (PP720) KW - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000) KW - Natural Resource Economics (EE115) (New March 2000) KW - Education and Training (CC100) KW - Agencies and Organizations (DD100) KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Storage Problems and Pests of Non-food/Non-feed Plant Products (SS210) KW - Residues and Contamination of Plant Products (SS220) (Discontinued March 2000) KW - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003026607&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Drug Discovery, Economic Development and Conservation: The International Cooperative Biodiversity Groups. AU - Rosenthal, J. P. A2 - Rosenthal, J. P. T2 - Pharmaceutical Biology T3 - Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups JO - Pharmaceutical Biology JF - Pharmaceutical Biology Y1 - 1999/// VL - 37 SP - 144 PP. EP - 144 PP. CY - Lisse; Netherlands PB - Swets & Zeitlinger SN - 1388-0209 AD - Rosenthal, J. P.: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892-2220, USA. N1 - Accession Number: 20003026602. Publication Type: Journal issue. Note: Drug discovery, economic development and conservation: The International Cooperative Biodiversity Groups Language: English. Subject Subsets: Plant Genetic Resources; Plant Breeding; Aromatic & Medicinal Plants; Forest Products; Tropical Diseases; Forestry; Public Health; Agricultural Entomology N2 - This special supplement of the journal Pharmaceutical Biology outlines the efforts of the International Cooperative Biodiversity Groups (ICBG) Programme, funded by the US Government in partnership with industry, in supporting multidisciplinary international partnerships between research institutions, companies, communities and non-governmental organizations promoting bioprospecting for new pharmaceutical and agricultural agents. Currently, research, development and conservation efforts are being carried out in 12 developing countries, USA and UK. Of the 9 papers presented in this issue, 6 were presented at the Annual Meeting of the American Society of Pharmacognosy, Orlando, Florida, in 1998. These papers are considerably expanded in content and updated relative to the presentations that were made in Orlando. All papers describe the work of different groups funded by the ICBG Programme. KW - conservation KW - diversity KW - economic development KW - indigenous knowledge KW - intellectual property rights KW - international agreements KW - international cooperation KW - medicinal plants KW - medicinal properties KW - natural products KW - phytochemicals KW - plant genetic resources KW - Developing Countries KW - UK KW - USA KW - countries KW - British Isles KW - Western Europe KW - Europe KW - Commonwealth of Nations KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - APEC countries KW - North America KW - America KW - Britain KW - drug plants KW - medicinal herbs KW - officinal plants KW - Third World KW - Underdeveloped Countries KW - United Kingdom KW - United States of America KW - Biological Resources (Plant) (PP720) KW - Biological Resources (Animal) (PP710) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000) KW - Plant Pests (FF620) (New March 2000) KW - Plant Composition (FF040) KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Non-wood Forest Products (KK540) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003026602&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis. AU - Müller, F. M. C. AU - Kasai, M. AU - Francesconi, A. AU - Brillante, B. AU - Roden, M. AU - Peter, J. AU - Chanock, S. J. AU - Walsh, T. J. JO - Journal of Clinical Microbiology JF - Journal of Clinical Microbiology Y1 - 1999/// VL - 37 IS - 10 SP - 3405 EP - 3408 SN - 0095-1137 AD - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19991202771. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The transmission of an azole-resistant, isogenic strain of C. albicans in an HIV-infected family from the USA, of 2 children with symptomatic oropharyngeal candidosis and a mother with asymptomatic colonization during a 5-year period, is reported. These findings were confirmed by 3 different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. KW - antifungal agents KW - asymptomatic infections KW - azoles KW - candidosis KW - case reports KW - children KW - colonization KW - disease transmission KW - drug resistance KW - epidemiology KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - identification KW - immunocompromised hosts KW - infection KW - infections KW - mouth KW - opportunistic infections KW - pharynx KW - polymerase chain reaction KW - techniques KW - USA KW - Candida albicans KW - man KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - candidiasis KW - fungistats KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - PCR KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202771&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Breakthrough Candida tropicalis fungemia during ketoconazole prophylaxis in cancer patients. AU - Krcmery, V., Jr. AU - Sejnova, D. AU - Pichnova, E. JO - Acta Oncologica JF - Acta Oncologica Y1 - 1999/// VL - 38 IS - 5 SP - 663 EP - 665 SN - 0001-6381 AD - Krcmery, V., Jr.: St. Elisabeth and Pediatric National Cancer Institute, Heydukova 10, 812 50 Bratislava, Slovakia. N1 - Accession Number: 20001201659. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 65277-42-1. KW - blood KW - drug therapy KW - fungaemia KW - human diseases KW - immunocompromised hosts KW - infections KW - ketoconazole KW - mycoses KW - neoplasms KW - opportunistic infections KW - prophylaxis KW - Slovakia KW - Candida KW - Candida tropicalis KW - man KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - cancers KW - chemotherapy KW - fungemia KW - fungus KW - Hyphomycetes KW - Pesticides and Drugs (General) (HH400) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001201659&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification, cloning, and synthesis of a novel salivary anti-thrombin from the mosquito Anopheles albimanus. AU - Valenzuela, J. G. AU - Francischetti, I. M. B. AU - Ribeiro, J. M. C. JO - Biochemistry (Washington) JF - Biochemistry (Washington) Y1 - 1999/// VL - 38 IS - 34 SP - 11209 EP - 11215 SN - 0006-2960 AD - Valenzuela, J. G.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, MSC-0425 Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000505317. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9002-04-4. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology N2 - An anti-thrombin peptide (anophelin) was isolated from the salivary glands of A. albimanus through molecular sieving and reverse-phase high-performance liquid chromatography. The purified peptide inhibited thrombin-induced platelet aggregation, thrombin esterolytic activity on a synthetic substrate, and thrombin cleavage of fibrinogen. The purified anti-thrombin had a molecular mass of 6342.4 Da. Its amino terminus was blocked, but internal sequence yielded 3 peptide sequences, which were used to design oligonucleotide probes for PCR amplification of salivary gland cDNA and isolation of the full-length clone. Analysis of the sequence of anophelin shows no similarities to any other anti-thrombin peptides. Anophelin was successfully synthesized and characterized to be a tight-binding, specific, and novel inhibitor of thrombin. The new nucleotide sequence was deposited in the EMBL/GenBank/DDBJ database under accession number AF125095. KW - characterization KW - DNA cloning KW - inhibitors KW - molecular genetics KW - nucleotide sequences KW - peptides KW - salivary glands KW - thrombin KW - Anopheles albimanus KW - Culicidae KW - Diptera KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - anophelin KW - biochemical genetics KW - DNA sequences KW - mosquitoes KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000) KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000505317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection. AU - Humphrey, R. W. AU - Wyvill, K. M. AU - Nguyen BachYen AU - Shay, L. E. AU - Kohler, D. R. AU - Steinberg, S. M. AU - Ueno, T. AU - Fukasawa, T. AU - Shintani, M. AU - Hayashi, H. AU - Mitsuya, H. AU - Yarchoan, R. JO - Antiviral Research JF - Antiviral Research Y1 - 1999/// VL - 41 IS - 1 SP - 21 EP - 33 SN - 0166-3542 AD - Humphrey, R. W.: HIV and AIDS Malignancy Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Rm. 12N226, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19992006610. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - The pharmacokinetics, toxicity, and activity of KNI-272, a transition state inhibitor of HIV-1 protease, was assessed in a phase I trial in Bethesda, Maryland, USA. After an initial phase in which the pharmacokinetics were assessed, 37 patients with AIDS or symptomatic HIV infection and 100-400 CD4 cells/mm³ were entered in an escalating dose study. KNI-272 was administered 4 times daily for up to 12 weeks. Oral bioavailability ranged from 22 to 55% and was not appreciably different in the fasting and post-prandial state. The dose limiting toxicity was hepatic transaminase elevation; this could be reduced by escalating the dose over 4 weeks. When administered this way, the maximum tolerated oral dose was 40 mg/kg per day. At the highest 2 tolerated doses (26.4 and 40 mg/kg per day), there was some evidence of an anti-HIV effect with median decreases of 0.2-0.3 log10 copies/ml plasma HIV RNA; these decreases persisted through 7-8 weeks of treatment. There was an upward trend in the CD4 count at the 40 mg/kg per day dose but not at other doses. Additional studies focused on approaches to improve the therapeutic index of KNI-272 may be warranted. KW - acquired immune deficiency syndrome KW - antiviral agents KW - antiviral properties KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - new drugs KW - pharmacokinetics KW - proteinase inhibitors KW - toxicity KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - anti-viral properties KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - protease inhibitors KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006610&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Visceral adipose tissue is not increased in Pima Indians compared with equally obese Caucasians and is not related to insulin action or secretion. AU - Gautier, J. F. AU - Milner, M. R. AU - Elam, E. AU - Chen, K. AU - Ravussin, E. AU - Pratley, R. E. JO - Diabetologia JF - Diabetologia Y1 - 1999/// VL - 42 IS - 1 SP - 28 EP - 34 SN - 0012-186X AD - Gautier, J. F.: Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, UK. N1 - Accession Number: 19991411857. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Pima Indians are insulin resistant and hyperinsulinaemic compared with Caucasians. The study investigated whether abdominal fat distribution was different between Pimas and Caucasians and whether differences in the amount of visceral fat explained metabolic differences between the groups. Total body fat (absorptiometry) and abdominal fat distribution at L4-L5 (magnetic resonance imaging) were compared in 20 Pima Indians (10 men/10 women) and 20 age-, sex- and BMI-matched Caucasians. Insulin action was measured as glucose disposal during a two-step hyperinsulinaemic-euglycaemic glucose clamp and insulin secretion was assessed in response to oral and intravenous glucose tolerance tests. By design, percent body fat was similar in Pimas and Caucasians. Abdominal visceral and subcutaneous adipose tissue areas were also similar in the two groups (151±16 vs. 139±15 cm² and 489±61 vs. 441±57 cm² respectively). Plasma insulin concentrations were higher in Pimas than Caucasians in the fasting state (27±6 vs. 11±2 mU/ml; P<0.01) and after a 75-g oral glucose load (area under the curve 19975±2626 vs. 9293±1847 mU/litre per 180 min; P<0.005). Glucose disposal was lower in Pimas than Caucasians during both steps of the clamp and negatively correlated (after adjustment for percent body fat and sex) with visceral adipose tissue in Caucasians (partial r=-0.51, P=0.03), but not in Pima Indians (r=-0.03, P=0.92). Insulin secretion was not related to visceral fat independently of percent body fat in either group. It is concluded that a relative increase in visceral fat does not explain insulin resistance and hyperinsulinaemia in Pima Indians. KW - abdominal fat KW - adipose tissue KW - American indians KW - body fat KW - distribution KW - ethnic groups KW - fasting KW - glucose tolerance KW - hyperinsulinaemia KW - insulin KW - insulin secretion KW - obesity KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood sugar tolerance KW - fatness KW - hyperinsulinemia KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411857&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adherence of Candida albicans to bladder mucosa: development and application of a tissue explant assay. AU - Lyman, C. A. AU - Navarro, E. AU - Garrett, K. F. AU - Roberts, D. D. AU - Pizzo, P. A. AU - Walsh, T. J. JO - Mycoses JF - Mycoses Y1 - 1999/// VL - 42 IS - 4 SP - 255 EP - 259 SN - 0933-7407 AD - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991202123. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology N2 - In order to study the interactions between Candida sp. and uroepithelial tissue, a tissue explant assay was developed using bladder mucosa harvested from New Zealand white rabbits. Blastoconidia of C. albicans, C. tropicalis and C. glabrata [Torulopsis glabrata] attached to the uroepithelial tissue in similar quantities. However, there was significantly more adherence to the uroepithelium by pre-germinated C. albicans compared with C. albicans blastoconidia. The amount of uroepithelial tissue injury was directly related to the length of exposure of the tissue to Candida. It is concluded that this tissue explant assay may provide a useful method for investigating properties related to fungal adherence to transitional uroepithelium and organism-mediated tissue injury. KW - adhesion KW - bladder KW - epithelium KW - interactions KW - trauma KW - Candida albicans KW - Candida glabrata KW - Candida tropicalis KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Torulopsis KW - Pezizomycotina KW - fungus KW - Hyphomycetes KW - Torulopsis glabrata KW - traumas KW - urinary bladder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202123&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients. AU - Piscitelli, S. C. AU - Kelly, G. AU - Walker, R. E. AU - Kovacs, J. AU - Falloon, J. AU - Davey, R. T., Jr. AU - Raje, S. AU - Masur, H. AU - Polis, M. A. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 3 SP - 647 EP - 650 SN - 0066-4804 AD - Piscitelli, S. C.: Department of Pharmacy, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992003998. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 3056-17-5. N2 - The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated in a study in 1995 in the USA. 10 HIV-infected patients with CD4 counts of <200 cells/mm³ received stavudine (40 mg twice daily) in combination with 1-3 other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with 3 opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen. KW - analogues KW - drug therapy KW - drugs KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - interactions KW - nucleoside analogues KW - nucleosides KW - opportunistic infections KW - pharmacokinetics KW - regimens KW - stavudine KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - analogs KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - medicines KW - nucleoside analogs KW - pharmaceuticals KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003998&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Sensitivity of spermidine-deficient Saccharomyces cerevisiae to paromomycin. AU - Balasundaram, D. AU - Tabor, C. W. AU - Tabor, H. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 5 SP - 1314 EP - 1316 SN - 0066-4804 AD - Balasundaram, D.: National Institutes of Health, Bethesda, MD 20892-0830, USA. N1 - Accession Number: 19991201725. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 7542-37-2. Subject Subsets: Medical & Veterinary Mycology N2 - Spermidine-deficient S. cerevisiae cells were more sensitive to paromomycin than nondeficient cells, resulting in cessation of growth and cell death. KW - antifungal agents KW - antifungal properties KW - paromomycin KW - susceptibility KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - Saccharomyces KW - Saccharomycetaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - aminosidine KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201725&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Heteroresistance to fluconazole and voriconazole in Cryptococcus neoformans. AU - Mondon, P. AU - Petter, R. AU - Amalfitano, G. AU - Luzzati, R. AU - Concia, E. AU - Polacheck, I. AU - Kwon-Chung, K. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 8 SP - 1856 EP - 1861 SN - 0066-4804 AD - Mondon, P.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 19991202460. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 86386-73-4, 137234-62-9. Subject Subsets: Medical & Veterinary Mycology N2 - C. neoformans isolates that exhibited unusual patterns of resistance to fluconazole and voriconazole were isolated from 7 isolates from 2 different geographical regions: one isolate from an Israeli non-AIDS patient and 6 serial isolates from an Italian AIDS patient who had suffered 6 recurrent episodes of cryptococcal meningitis. Each isolate produced cultures with heterogeneous compositions in which most of the cells were susceptible, but cells highly resistant to fluconazole (minimum inhibitory concentration (MIC) ≥64 µg/ml) were recovered at a variable frequency (7 × 10-3 to 4.6 × 10-2). Evidence showed that this type of resistance was innate and was unrelated to drug exposure since the Israeli patient had never been treated with azoles or any other antimycotic agents. Analysis of clonal subpopulations of these 2 strains showed that they exhibited heterogeneous patterns of resistance. The number of subpopulations which grew on fluconazole or voriconazole agar declined progressively with increasing azole concentration without a sharp cut-off point. For the Italian serial isolates, the number of clonal populations resistant to fluconazole (64 µg/ml) and voriconazole (1 µg/ml) increased steadily, yielding the highest number for the isolate from the last episode. Attempts to purify a sensitive subpopulation failed, but clones highly resistant to fluconazole (100 µg/ml) and moderately resistant to voriconazole (1 µg/ml) always produced a homogeneous population of resistant cells. Upon maintenance on drug-free medium, however, the majority of the homogeneously resistant cells of these subclones lost their resistance and returned to the stable initial heteroresistant phenotype. The pattern of heteroresistance was not affected by the pH or osmolarity of the medium but was influenced by temperature. The resistance appeared to be suppressed at 35°C and was completely abolished at 40°C. Although heterogeneity in azole resistance among subpopulations of single isolates has been reported for Candida sp., the transient changes in expression of resistance under different growth conditions reported here have not been observed in fungal pathogens. KW - acquired immune deficiency syndrome KW - antifungal agents KW - azoles KW - central nervous system KW - clones KW - cryptococcal meningitis KW - cryptococcosis KW - drug resistance KW - fluconazole KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - meningitis KW - opportunistic infections KW - phenotypes KW - temperature KW - voriconazole KW - Cryptococcus neoformans KW - man KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - AIDS KW - CNS KW - european blastomycosis KW - fungistats KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - meningeal cryptococcosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202460&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Antifungal activity of LY303366, a novel echinocandin B, in experimental disseminated candidiasis in rabbits. AU - Petraitiene, R. AU - Petraitis, V. AU - Groll, A. H. AU - Candelario, M. AU - Sein, T. AU - Bell, A. AU - Lyman, C. A. AU - McMillian, C. L. AU - Bacher, J. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 9 SP - 2148 EP - 2155 SN - 0066-4804 AD - Petraitiene, R.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991203052. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 1397-89-3, 86386-73-4, 7440-09-7. Subject Subsets: Medical & Veterinary Mycology N2 - The safety and antifungal activity of LY303366 (LY), a new broad-spectrum semisynthetic echinocandin, were studied against disseminated candidosis in persistently neutropenic rabbits. In vitro time-kill assays demonstrated that LY has concentration-dependent fungicidal activity. The pharmacokinetics of LY in the plasma of non-neutropenic rabbits suggested a linear relationship between dose and area under the curve (AUC). The times spent above the minimum inhibitory concentration (MIC) during the experimental dosing interval of 24 h were 4 h for LY at 0.1 mg/kg of body weight/day (LY0.1), 8 h for LY at 0.25 mg/kg daily (LY0.25), 12 h for LY at 0.5 mg/kg daily (LY0.5), and 20 h for LY at 1 mg/kg daily (LY1). Antifungal therapy was administered to infected rabbits for 10 days starting 24 h after the intravenous (i.v.) inoculation of 10³Candida albicans blastoconidia. Study groups consisted of untreated controls (UCs) and animals treated with amphotericin B (AmB; 1 mg/kg daily i.v.), fluconazole (FLU; 10 mg/kg daily i.v.) and LY0.1, LY0.25, LY0.5 or LY1 i.v. Rabbits treated with LY0.5, LY1, AmB and FLU had similarly significant clearance of C. albicans from the liver, spleen, kidney, lung, vena cava and brain in comparison to that for UCs. There was a dose-dependent clearance of C. albicans from tissues in response to LY. Among rabbits treated with LY0.1 there was a significant reduction of C. albicans only in the spleen. In animals treated with LY0.25 there was a significant reduction in all tissues but the brain. By comparison, LY0.5 and LY1 cleared all tissues, including the brain, of C. albicans. These in vivo findings were consistent with the results of in vitro time-kill assays. A dose-dependent effect of altered cell wall morphology was observed among UCs and animals treated with LY0.1, and LY0.25, with a progressive transition from hyphal structure to disrupted yeast forms. Serum creatinine levels were higher and serum potassium levels were lower in AmB-treated rabbits than in UCs and LY- and FLU-treated rabbits. LY0.5 and LY1 were well tolerated, displayed predictable pharmacokinetics in plasma, and had activities comparable to those of AmB and FLU in the treatment of disseminated candidosis in persistently neutropenic rabbits. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - blood plasma KW - candidosis KW - cell walls KW - disseminated infections KW - drug therapy KW - echinocandins KW - experimental infections KW - fluconazole KW - in vitro KW - infections KW - inoculation KW - liver KW - lungs KW - pharmacokinetics KW - potassium KW - safety KW - spleen KW - yeasts KW - Candida KW - Candida albicans KW - rabbits KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - Candida KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-fungal properties KW - candidiasis KW - chemotherapy KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - LY303366 KW - plasma (blood) KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203052&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of the hematoregulatory peptide SK&F 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits. AU - Lyman, C. A. AU - Gonzalez, C. AU - Schneider, M. AU - Lee, J. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 9 SP - 2165 EP - 2169 SN - 0066-4804 AD - Lyman, C. A.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991203053. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - The effects of SK&F 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidosis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SK&F 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of colony forming units (CFU)/g in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SK&F 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. The results suggested a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidosis in the setting of profound and persistent neutropenia. KW - amphotericin B KW - antifungal agents KW - antifungal properties KW - candidosis KW - disseminated infections KW - drug therapy KW - experimental infections KW - infections KW - neutropenia KW - neutrophils KW - spleen KW - Candida KW - Candida albicans KW - rabbits KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - anti-fungal properties KW - candidiasis KW - chemotherapy KW - fungicidal properties KW - fungistats KW - fungus KW - Hyphomycetes KW - SK&F 107647 KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203053&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization. AU - Xu YanYing AU - Ambudkar, I. AU - Yamagishi, H. AU - Swaim, W. AU - Walsh, T. J. AU - O'Connell, B. C. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 9 SP - 2256 EP - 2262 SN - 0066-4804 AD - Xu YanYing: Gene Therapy and Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991203056. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Radiolabelled histatin 3, was used to show that the protein binds to C. albicans spheroplasts in a manner that is dependent on time and concentration. Binding to the spheroplasts was saturable and could be competed with unlabelled histatin 3. A single histatin 3 binding site with a Kd=5.1 µM was detected. Histatin 3 binding resulted in potassium and magnesium efflux, predominantly within the first 30 min of incubation. Studies with fluorescent histatin 3 demonstrate that the protein is internalized by C. albicans and that translocation of histatin inside the cell is closely associated with cell death. Histatin binding, internalization, and cell death were accelerated in low-ionic-strength conditions. A low extracellular salt concentration was essential for cell death to occur, even when histatin 3 was already bound to the cell. The interaction of histatin 3 with C. albicans, and subsequent cell death, was inhibited at low temperature. These results demonstrate that the candidacidal activity of histatin 3 is not due exclusively to binding at the cell surface but also involves subsequent interactions with the cell. KW - antifungal agents KW - antifungal properties KW - in vitro KW - proteins KW - saliva KW - temperature KW - Candida KW - Candida albicans KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Candida KW - anti-fungal properties KW - fungicidal properties KW - fungistats KW - fungus KW - histatins KW - histidine-rich proteins KW - Hyphomycetes KW - salivary secretions KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pharmacokinetics and safety of high-dose and extended-interval regimens of levofloxacin in human immunodeficiency virus-infected patients. AU - Piscitelli, S. C. AU - Spooner, K. AU - Baird, B. AU - Chow, A. T. AU - Fowler, C. L. AU - Williams, R. R. AU - Jaya Natarajan AU - Masur, H. AU - Walker, R. E. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 9 SP - 2323 EP - 2327 SN - 0066-4804 AD - Piscitelli, S. C.: Bldg. 10, Rm. 11C103, National Institutes of Health, 10 Center Dr. MSC 1880, Bethesda, MD 20892-1880, USA. N1 - Accession Number: 19992012601. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 100986-85-4. N2 - The pharmacokinetics of levofloxacin, administered in high doses and with extended dosing intervals, was studied in human immunodeficiency virus (HIV)-infected patients. 30 patients received either 750 mg of the drug or a placebo once daily for 14 days, followed by 750 mg or 1000 mg of the drug or a placebo 3 times weekly for an additional 14 days. Levofloxacin disposition was characterized by rapid oral absorption, with peak concentrations occurring approximately 1.5 h after dosing and elimination half-lives from 7.2 to 9.4 h. The overall incidence of any adverse effect was 70% (1000 mg) to 95% (750 mg) for levofloxacin-treated patients and 71% for those taking the placebo. Levofloxacin pharmacokinetic parameters for HIV-infected patients were consistent with those observed in studies of healthy volunteers. KW - antibacterial agents KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - levofloxacin KW - pharmacokinetics KW - regimens KW - safety KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012601&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits. AU - Groll, A. H. AU - Petraitis, V. AU - Petraitiene, R. AU - Field-Ridley, A. AU - Calendario, M. AU - Bacher, J. AU - Piscitelli, S. C. AU - Walsh, T. J. JO - Antimicrobial Agents and Chemotherapy JF - Antimicrobial Agents and Chemotherapy Y1 - 1999/// VL - 43 IS - 10 SP - 2463 EP - 2467 SN - 0066-4804 AD - Groll, A. H.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10, Center Dr., Bethesda, MD 20892, USA. N1 - Accession Number: 19991203131. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 1397-89-3, 86386-73-4, 1400-61-9. Subject Subsets: Medical & Veterinary Mycology N2 - The activity of liposomal nystatin (L-Nys) against subacute disseminated candidosis was investigated in persistently neutropenic rabbits. Antifungal therapy was administered for 10 days starting 24 h after intravenous inoculation of 10³ blastoconidia of Candida albicans. Responses to treatment were assessed by the quantitative clearance of the organism from blood and tissues. Treatments consisted of L-Nys at dosages of 2 and 4 mg/kg daily (L-Nys2 and L-Nys4, respectively) amphotericin B deoxycholate at 1 mg/kg daily (D-AmB) and fluconazole at 10 mg/kg daily (Flu). All treatments were given intravenously once daily. Compared with the results for untreated but infected control animals, treatment with L-Nys2, L-Nys4, D-AmB and Flu resulted in a significant clearance of the residual burden of C. albicans from the kidney, liver, spleen, lung and brain (P<0.0001). When the proportion of animals infected at at least one of the 5 tissue sites studied was evaluated, a dose-dependent response to treatment with L-Nys was found (P<0.05). Compared to D-AmB-treated rabbits, mean serum creatinine and blood urea nitrogen levels at the end of therapy were significantly lower in animals treated with L-Nys2 (P<0.001) and L-Nys4 (P<0.001 and P<0.01, respectively). It is concluded that L-Nys was less nephrotoxic than conventional amphotericin B and had dose-dependent activity comparable to that of amphotericin B for the early treatment of subacute disseminated candidosis in persistently neutropenic rabbits. KW - amphotericin B KW - antifungal agents KW - application methods KW - candidosis KW - disseminated infections KW - drug formulations KW - drug therapy KW - experimental infections KW - fluconazole KW - infections KW - liposomes KW - liver KW - lungs KW - nephrotoxicity KW - nystatin KW - Candida albicans KW - rabbits KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Leporidae KW - Lagomorpha KW - mammals KW - vertebrates KW - Chordata KW - animals KW - candidiasis KW - ceratocide KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991203131&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolating expressed microsporidial genes using a cDNA subtractive hybridization approach. AU - Hayman, J. R. AU - Nash, T. E. A2 - Kaneshiro, E. S. JO - Journal of Eukaryotic Microbiology JF - Journal of Eukaryotic Microbiology Y1 - 1999/// VL - 46 IS - 5 SP - 21S EP - 24S SN - 1066-5234 AD - Hayman, J. R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892, USA. N1 - Accession Number: 20000804607. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Registry Number: 9064-37-3. Subject Subsets: Protozoology N2 - Genes expressed by Encephalitozoon intestinalis during the invasion of host cells were identified by taking total messenger RNA (mRNA) and using complementary DNA (cDNA) subtractive hybridization to remove some sequences common to the host and parasite, leaving a higher proportion of sequences unique to the parasite. A number of sequences were cloned and sequenced, and 3 clones were found to have significant similarity to different regions of actin from different species. Further tests confirmed that they were of parasite origin. The full length predicted amino acid sequence of the combined clones was compared with known partial sequences of actin genes from E. hellem, Vairimorpha necatrix and Nosema locustae, and found to be 96%, 79% and 74% identical, respectively. It is concluded that the cDNA subtraction method is effective in isolating expressed microsporidial genes. KW - actin KW - amino acid sequences KW - cell invasion KW - complementary DNA KW - genes KW - messenger RNA KW - molecular genetics KW - nucleotide sequences KW - parasites KW - techniques KW - Encephalitozoon intestinalis KW - protozoa KW - Encephalitozoon KW - Encephalitozoonidae KW - Microspora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - cDNA KW - DNA sequences KW - mRNA KW - protein sequences KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804607&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. AU - Schrauwen, P. AU - Xia AU - Bogardus, C. AU - Pratley, R. E. AU - Ravussin, E. JO - Diabetes (New York) JF - Diabetes (New York) Y1 - 1999/// VL - 48 IS - 1 SP - 146 EP - 149 SN - 0012-1797 AD - Schrauwen, P.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. N1 - Accession Number: 19991409009. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition N2 - The recent discovery of uncoupling protein (UCP)-2 and UCP-3, and their high expression in skeletal muscle, has renewed interest in a possible role for these proteins in underlying the variability in energy expenditure and therefore metabolic efficiency. Using reverse transcription-polymerase chain reaction, levels of expression of UCP-2 and long and short forms of UCP-3 were measured in skeletal muscle of 19 nondiabetic, male Pima Indians covering a wide range of body weight. 24-h energy expenditure was measured in a respiratory chamber in 16 of these individuals. BMI was negatively correlated with the expression levels of the long (r=-0.53, P=0.025) and short (r=-0.46, P=0.047) forms of UCP-3. BMI was not correlated with UCP-2 expression. Metabolic rate during sleep, adjusted for fat-free mass and fat mass, was positively correlated with the long form of UCP-3 (r=0.69, P=0.006). These results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians. KW - American indians KW - energy metabolism KW - ethnic groups KW - gene expression KW - skeletal muscle KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - uncoupling protein KW - United States of America KW - Physiology of Human Nutrition (VV120) KW - Social Structure (UU480) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409009&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hypothalamic-pituitary-adrenal axis and sympathetic nervous system activities in Pima Indians and Caucasians. AU - Tataranni, P. A. AU - Cizza, G. AU - Snitker, S. AU - Gucciardo, F. AU - Lotsikas, A. AU - Chrousos, G. P. AU - Ravussin, E. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1999/// VL - 48 IS - 3 SP - 395 EP - 399 SN - 0026-0495 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Phoenix, Arizona, USA. N1 - Accession Number: 19991406784. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9002-60-2, 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1. Subject Subsets: Human Nutrition N2 - It was hypothesized that hypercortisolism and low sympathetic nervous system (SNS) activity may be found in association in Pima Indians, a population with a high prevalence of obesity. Indices of hypothalamic-pituitary-adrenal (HPA) axis and SNS activities were measured in 39 nondiabetic men, 20 Pima Indians (age, 30±5 years; weight, 94±26 kg; 35±8% body fat (mean ± SD)) and 19 Caucasians (33±9 years, 91±23 kg, 28±11% body fat). HPA axis activity was assessed by measurements of morning fasting plasma corticotropin (ACTH) and cortisol concentrations and 24-h urinary free cortisol (UFC) excretion. SNS activity was assessed as muscle sympathetic nerve activity (MSNA) by microneurography and by measurement of catecholamines (fasting plasma concentration and 24-h urinary excretion). Plasma ACTH and cortisol and UFC were similar in Pima Indians and Caucasians. MSNA was positively correlated with percent body fat (r=0.49, P=0.002) and was lower in Pima Indians compared with Caucasians after adjustment for percent body fat (24±9 vs. 31±10 bursts/min, P=0.04). It is concluded that Pima Indians, a population with a high prevalence of obesity, have lower SNS activity but normal HPA axis activity compared with Caucasians. KW - adrenal glands KW - body fat KW - catecholamines KW - corticotropin KW - ethnic groups KW - hydrocortisone KW - hypothalamus KW - obesity KW - pituitary KW - sympathetic nervous system KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACTH KW - adrenals KW - adrenocorticotropic hormone KW - adrenocorticotropin KW - cortisol KW - fatness KW - hypophysis KW - pituitary gland KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991406784&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Interrelationships of spontaneous growth hormone axis activity, body fat, and serum lipids in healthy elderly women and men. AU - O'Connor, K. G. AU - Harman, S. M. AU - Stevens, T. E. AU - Jayme, J. J. AU - Bellantoni, M. F. AU - Busby-Whitehead, M. J. AU - Christmas, C. AU - Münzer, T. AU - Tobin, J. D. AU - Roy, T. A. AU - Cottrell, E. AU - St. Clair, C. AU - Pabst, K. M. AU - Blackman, M. R. JO - Metabolism, Clinical and Experimental JF - Metabolism, Clinical and Experimental Y1 - 1999/// VL - 48 IS - 11 SP - 1424 EP - 1431 SN - 0026-0495 AD - O'Connor, K. G.: Endocrine and Applied Physiology Sections, Gerontology Research Center, National Institute on Aging, National Institutes of Health (NIH), Baltimore, MD, USA. N1 - Accession Number: 20001408199. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 57-88-5, 61912-98-9, 9002-72-6. Subject Subsets: Human Nutrition N2 - The relation between growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis function and lipid profile was examined by evaluating GH secretion, serum IGF-I and IGF binding protein-3 (IGFBP-3) levels, adiposity via the body mass index (BMI), waist to hip ratio (WHR), dual-energy x-ray absorptiometry (DEXA), and magnetic resonance imaging (MRI), and circulating lipids in 101 healthy subjects older than 65 years at John Hopkins Bayview Medical Centre, Maryland, USA [date not given]. Integrated nocturnal GH secretion (log IAUPGH) was inversely related (P < 0.005) to DEXA total and abdominal fat and MRI visceral fat in both genders. Log IAUPGH was inversely related to visceral fat in women (P < 0.005) and men (P < 0.0001), but was not significantly related to total fat in either gender. In women, log IAUPGH was related inversely to total and LDL cholesterol and positively to HDL cholesterol (P < 0.008). In men, log IAUPGH was inversely related to total cholesterol and triglycerides (P < 0.005). In women, HDL cholesterol was inversely related to the WHR (P < 0.005). In men, triglycerides were positively related (P ,less than 0.001) to the WHR and DEXA abdominal and MRI visceral fat. Multivariate regression revealed log IAUPGH, but not DEXA total body fat, to be an independent determinant of total (P < 0.001 for women and P = 0.01 for men) and LDL (P < 0.007 and P = 0.05) cholesterol in both sexes and of HDL cholesterol (P < 0.005) and triglycerides (P < 0.03) in women. Log IAUPGH, but not DEXA abdominal fat, was related to total (P < 0.005 and P < 0.03) and LDL (P < 0.03 and P = 0.05) cholesterol in both genders and to HDL in women (P < 0.05). Log IAUPGH, but not MRI visceral fat, was related to total cholesterol (P < 0.03 and P = 0.05) in women and men. Age, IGF, and IGFBP-3 were not significantly related to any body fat or lipid measures, except for a positive correlation of IGF-I with triglycerides in men. It is concluded that the endogenous nocturnal GH secretion predicts total, LDL, and HDL cholesterol levels independently of total or abdominal fat, suggesting that it is an independent cardiometabolic risk factor in healthy elderly people. KW - blood lipids KW - blood serum KW - body fat KW - body mass index KW - cholesterol KW - elderly KW - high density lipoprotein KW - human diseases KW - insulin-like growth factor KW - lipids KW - low density lipoprotein KW - magnetic resonance imaging KW - old age KW - risk factors KW - sex differences KW - somatotropin KW - triacylglycerols KW - Maryland KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aged KW - elderly people KW - growth hormone KW - lipins KW - older adults KW - senior citizens KW - somatomedin C KW - triglycerides KW - United States of America KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001408199&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Management of a measles outbreak among Old World nonhuman primates. AU - Willy, M. E. AU - Woodward, R. A. AU - Thornton, V. B. AU - Wolff, A. V. AU - Flynn, B. M. AU - Heath, J. L. AU - Villamarzo, Y. S. AU - Smith, S. AU - Bellini, W. J. AU - Rota, P. A. JO - Laboratory Animal Science JF - Laboratory Animal Science Y1 - 1999/// VL - 49 IS - 1 SP - 42 EP - 48 SN - 0023-6764 AD - Willy, M. E.: Hospital Epidemiology Service, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992207325. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Veterinary Science; Veterinary Science N2 - A measles outbreak occurred in a US facility housing primates (including Macaca mulatta, M. fascicularis and M. nemestrina) in 1996. Serum and urine specimens were collected from monkeys housed in the room where the initial measles cases were identified, other monkeys with suspicious measles-like signs, and employees working in the affected areas. Serum specimens were tested for measles virus-specific IgG and IgM antibodies, and urine specimens were tested for measles virus by virus isolation or reverse transcriptase-polymerase chain reaction. 94 monkeys in 2 separate facilities had evidence of an acute measles infection. The outbreak was caused by a wild-type virus that had been associated with recent human cases of acute measles in the USA; however, an investigation was unable to identify the original source of the outbreak. Quarantine and massive vaccination helped to control further spread of infection. KW - disease control KW - introduced species KW - laboratory animals KW - outbreaks KW - quarantine KW - vaccination KW - viral diseases KW - zoonoses KW - Maryland KW - USA KW - Macaca fascicularis KW - Macaca mulatta KW - Macaca nemestrina KW - man KW - measles virus KW - monkeys KW - Morbillivirus KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Morbillivirus KW - Paramyxovirinae KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - exotic organisms KW - exotic species KW - introduced organisms KW - non-indigenous organisms KW - non-indigenous species KW - non-native organisms KW - non-native species KW - nonindigenous organisms KW - nonindigenous species KW - United States of America KW - viral infections KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Laboratory Animal Science (LL040) KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207325&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinicopathological features and management of Pakistani patients with multiple myeloma. AU - Hina Shaheen AU - Imran Ghanghroo AU - Imtiaz Malik JO - Journal of the Pakistan Medical Association JF - Journal of the Pakistan Medical Association Y1 - 1999/// VL - 49 IS - 10 SP - 233 EP - 237 SN - 0030-9982 AD - Hina Shaheen: National Cancer Institute and Research Center, Karachi, Pakistan. N1 - Accession Number: 20002009856. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 50-24-8, 5060-55-9, 52-21-1, 630-67-1, 1107-99-9, 125-02-0. Subject Subsets: Tropical Diseases N2 - A retrospective analysis was conducted of 99 newly diagnosed patients with multiple myeloma seen during 1988-96 in Pakistan. Diagnostic criteria included bone marrow plasmacytosis, monoclonal gammopathy in serum or urine and radiological evidence of skeletal lesions. There were 57 males and 42 females. Mean age of the patients was 58 years, range 23-86 years. One-third of the patients were bed-ridden at the time of presentation. Common presenting symptoms included bone pain (82%), fatigue (78%) and backache (73%). Physical findings, laboratory features and radiological assessment revealed pallor (56%), severe anaemia with haemoglobin <8.5 gm/dl (39%), creatinine ≥2 2 mg/dl (57%), serum calcium ≥12 gm/dl (23%), uric acid ≥8 gm/dl (47%) and albumin≤3.5 gm/dl (63%). The most common monoclonal gammopathy was IgG kappa. 71% of the patients presented with stage III disease. The most common chemotherapeutic regimen utilized was melphalan and prednisolone which was administered to 88% of the patients. Complete remission was observed in 25% and partial remission in 36% of the evaluated patients. Commonest complication during the course of disease was related to skeletal involvement followed by renal failure and bone marrow suppression. Median survival of the patients was 34 months. It is concluded that multiple myeloma patients in Pakistan are younger, more frequently have poor performance status and more often present with advanced stage of disease. Response to therapy, however, is adequate and survival is comparable to Western patients. KW - clinical aspects KW - complications KW - diagnosis KW - drug therapy KW - human diseases KW - myeloma KW - pathology KW - prednisolone KW - prognosis KW - survival KW - Pakistan KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - chemotherapy KW - clinical picture KW - melphalan KW - multiple myeloma KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pesticides and Drugs; Control (HH405) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009856&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hypericum perforatum extracts as potential antidepressants. AU - Vitiello, B. JO - Journal of Pharmacy and Pharmacology JF - Journal of Pharmacy and Pharmacology Y1 - 1999/// VL - 51 IS - 5 SP - 513 EP - 517 SN - 0022-3573 AD - Vitiello, B.: National Institute of Mental Health, Room 7147, 6001 Executive Boulevard, Bethesda MD, USA. N1 - Accession Number: 19990308906. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 20 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Extracts of H. perforatum have been used in the treatment of mild to moderate depression for many years in Europe. More recently, these extracts have become available in the USA as dietary supplements and have been popularly used to improve mood. In support of this practice, data from several controlled clinical studies suggest that H. perforatum is better than placebo and as effective as established antidepressant drugs. These data have, however, several limitations, indicating the need for more research. Extant data on the safety and efficacy of H. perforatum extracts in depression are here critically reviewed and plans for further research presented. KW - antidepressants KW - clinical trials KW - depression KW - efficacy KW - medicinal plants KW - pharmacology KW - plant extracts KW - reviews KW - safety KW - treatment KW - Europe KW - USA KW - Hypericum perforatum KW - Hypericum KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - drug plants KW - medicinal herbs KW - officinal plants KW - United States of America KW - Plant Science (General) (FF000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990308906&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Distribution and metabolism of (5-Hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration. AU - Godfrey, V. B. AU - Chen LingJen AU - Griffin, R. J. AU - Lebetkin, E. H. AU - Burka, L. T. JO - Journal of Toxicology and Environmental Health. Part A JF - Journal of Toxicology and Environmental Health. Part A Y1 - 1999/// VL - 57 IS - 3 SP - 199 EP - 210 AD - Godfrey, V. B.: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 19991410211. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 67-47-0. Subject Subsets: Human Nutrition N2 - Recent reports have shown (5-Hydroxymethyl)furfural (HMF) to be an in vitro mutagen after sulfate conjugation and to be a promoter as well as a weak initiator of colonic aberrant foci in rats. In order to investigate the metabolic activation further and to provide information for HMF toxicology studies, the disposition of [14C]-HMF was investigated in male F344 rats and B6C3F1 mice following administration of either 5, 10, 100, or 500 mg/kg by gavage. Tissue distribution results indicated that absorption of HMF was rapid in male rats and mice and that tissue concentrations in male mice at the earliest time point were not linearly proportional to dose. Excretion was primarily via the urine in both, with 60-80% of the administered dose excreted by this route in 48 h. Tissue/blood ratios of HMF-derived radioactivity were greater than 1 for liver and kidney. Three metabolites were identified and quantitated in urine. Formation of one of the metabolites, N-(5-hydroxy-methyl-2-furoyl)glycine, was inversely proportional to dose in rats but not mice. None of the metabolites were sulfate conjugates nor likely to be formed from sulfate conjugates. There were relatively low levels of non-extractable radioactivity in liver, kidney, and intestines, indicating that some reactive intermediate(s) may be formed. KW - blood KW - excretion KW - HMF KW - kidneys KW - liver KW - Maillard reaction KW - metabolism KW - metabolites KW - mutagens KW - tissues KW - toxicity KW - toxicology KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - hydroxymethylfurfural KW - non-enzymatic browning KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410211&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Type 2 diabetes among the Pima Indians of Arizona: an epidemic attributable to environmental change? AU - Bennett, P. H. A2 - Arroyo, P. A2 - Bourges, H. JO - Nutrition Reviews JF - Nutrition Reviews Y1 - 1999/// VL - 57 IS - 5, II SP - S51 EP - S54 SN - 0029-6643 AD - Bennett, P. H.: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, Arizona 85014, USA. N1 - Accession Number: 19991410682. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition N2 - The history of diabetes in the Pima Indians of Arizona, USA, is described and risk factors are discussed, including genetic factors, obesity, physical activity, bottle feeding of infants, low birth weight and maternal factors. It is considered that diabetes in this group is a clear example of genetic-environmental interaction, genetic susceptibility being a prerequisite for the development of the disease and exposure to adverse environmental factors being essential for its appearance. KW - birth weight KW - diabetes mellitus KW - environment KW - ethnic groups KW - genetic factors KW - infant feeding KW - infants KW - obesity KW - physical activity KW - risk factors KW - Arizona KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mountain States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Southwestern States of USA KW - fatness KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410682&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in breast milk from two cities in Ukraine. AU - Gladen, B. C. AU - Schecter, A. J. AU - Päpke, O. AU - Shkyryak-Nyzhnyk, Z. A. AU - Hryhorczuk, D. O. AU - Little, R. E. JO - Journal of Toxicology and Environmental Health. Part A JF - Journal of Toxicology and Environmental Health. Part A Y1 - 1999/// VL - 58 IS - 3 SP - 119 EP - 127 AD - Gladen, B. C.: Biostatistics Branch, Mail Drop A3-03, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19990405266. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Dairy Science; Human Nutrition N2 - A study was carried out to determine polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF) and coplanar polychlorinated biphenyls (PCB) in human milk in the Ukraine. Samples of milk were obtained from 200 women from the cities of Kyiv and Dniprodzerzhinsk. The samples were combined into 4 pools by city and age, and analysed for 7 PCDD, 10 PCDF and 2 coplanar PCB (126 and 169). The total of the measured PCDD, expressed as toxic equivalents, ranged from 5.1 to 7.6 pg/g lipid; for PCDF from 3.6 to 5.2, and for PCB from 11 to 18 pg/g lipid. Results from the 2 cities were similar; older women had slightly higher concentrations than did younger women. Levels of these compounds seen in Ukraine were similar to or lower than those seen in other recent studies from European and Asian countries. KW - contamination KW - dioxins KW - human milk KW - pollution KW - polychlorinated biphenyls KW - polychlorinated dibenzofurans KW - women KW - Ukraine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central Europe KW - Europe KW - Developed Countries KW - breast milk KW - environmental pollution KW - PCBs KW - Pollution and Degradation (PP600) KW - Milk and Dairy Produce (QQ010) KW - Physiology of Human Nutrition (VV120) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990405266&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adeno-associated virus and development of cervical neoplasia. AU - Strickler, H. D. AU - Viscidi, R. AU - Escoffery, C. AU - Rattray, C. AU - Kotloff, K. L. AU - Goldberg, J. AU - Manns, A. AU - Rabkin, C. AU - Daniel, R. AU - Hanchard, B. AU - Brown, C. AU - Hutchinson, M. AU - Zanizer, D. AU - Palefsky, J. AU - Burk, R. D. AU - Cranston, B. AU - Clayman, B. AU - Shah, K. V. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1999/// VL - 59 IS - 1 SP - 60 EP - 65 SN - 0146-6615 AD - Strickler, H. D.: Viral Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA. N1 - Accession Number: 19992009795. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health; Tropical Diseases N2 - Evidence from several sources has suggested that adeno-associated virus (AAV) infection might protect against cervical cancer, in part, by interfering with human papillomavirus (HPV)-induced tumourigenesis. Detection of AAV type 2 (AAV-2) DNA in cervical tissues has been reported. However, there have been few in vivo studies of women with cervical HPV infection or neoplasia, and these have reported inconsistent results. Polymerase chain reaction (PCR) assays targeted to the AAV-2 rep and cap genes were used to test tissue specimens from women in an epidemiological study of cervical neoplasia in Jamaica. 105 women with low-grade cervical intraepithelial neoplasia (CIN-1), 92 women with CIN-3/carcinoma in situ or invasive cancer (CIN-3/CA), and 94 normal subjects were tested. PCR amplification of human β-globin DNA was found in almost all cervical specimens, indicating that these materials were adequate for PCR testing. The prevalence of HPV DNA, determined by HPV L1 consensus primer PCR was, as expected, strongly associated with presence and grade of neoplasia. Each of the AAV PCR assays detected as few as 10 copies of the virus genome. However, none of the 291 cervical specimens from Jamaican subjects tested positive for AAV DNA. Negative AAV PCR results were also obtained in tests of cervical samples from 79 university students in the USA. Exposure to AAV was assessed further by serology. Using a whole virus AAV-2 sandwich enzyme-linked immunosorbent assay, no relationship was found between AAV antibodies and presence or grade of neoplasia in either the Jamaican study subjects or women enrolled in a US cervical cancer case (n=74) -control (n=77) study. Overall, the data provide no evidence that AAV infection plays a role in cervical tumourigenesis or that AAV commonly infects cervical epithelial cells. KW - antibodies KW - cervical cancer KW - cervix KW - disease prevention KW - DNA KW - epidemiology KW - genes KW - genomes KW - human diseases KW - neoplasms KW - pathogenesis KW - protection KW - serology KW - women KW - Jamaica KW - adeno-associated virus KW - human papillomaviruses KW - man KW - Parvoviridae KW - ssDNA viruses KW - DNA viruses KW - viruses KW - Papillomavirus KW - dsDNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - Papillomaviridae KW - cancers KW - deoxyribonucleic acid KW - human papillomavirus KW - Papovaviridae KW - Techniques and Methodology (ZZ900) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009795&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. AU - Zhu WeiYong AU - Jones, C. S. AU - Amin, S. AU - Matsukuma, K. AU - Haque, M. AU - Vuligonda, V. AU - Chandraratna, R. A. S. AU - Luca, L. M. de JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1999/// VL - 59 IS - 1 SP - 85 EP - 90 SN - 0008-5472 AD - Zhu WeiYong: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. N1 - Accession Number: 19991403261. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition N2 - Treatment of oestrogen receptor (ER)-positive MCF-7 human breast cancer cells with retinoic acid (RA) inhibited cell growth and increased cell adhesion to fibronectin. In contrast, ER- MDA-MB-231 cells failed to respond. Western blot analysis showed that tyrosine phosphorylation of two major bands at Mr 125 000 and Mr 68 000 was induced by RA in ER+ MCF-7 human breast carcinoma cells. However, this induction was a late phenomenon detectable at 12 and 24 h, but not within 3 h. A similar increase of tyrosine phosphorylation by RA was observed in ER+ human breast cancer cell lines T-47D and ZR-75-1, but not in the ER- cell lines MDA-MB-231, MDA-MB-453, and MDA-MB-468. Focal adhesion kinase and paxillin, which localize in focal adhesion plaques and may play important roles in the integrin signalling pathway, were identified as the major proteins showing RA-induced tyrosine phosphorylation. The retinoid X receptor-selective compound SR11237 failed to induce tyrosine phosphorylation, indicating that retinoid X receptor activation is not involved in this phenomenon. In contrast, stable overexpression of a truncated RA receptor (RAR) α cDNA, RARα403, with strong RAR dominant negative activity prevented the increase in tyrosine phosphate, suggesting that RAR signalling is involved in RA-induced tyrosine phosphorylation. Tyrosine phosphorylation was induced the most by the RAR-α (193836), followed by RAR-γ (194433), but was not significantly induced by RAR-β (193174)-selective retinoids. This study demonstrates a coordinated albeit relatively late effect of RA on cell adhesion and tyrosine phosphorylation in ER+ human breast cancer cells and suggests RAR-α as the major responsible retinoid receptor. KW - adhesion KW - breast cancer KW - cell cultures KW - growth KW - mammary gland neoplasms KW - neoplasms KW - phosphorylation KW - receptors KW - retinoic acid KW - cancers KW - fibronectin KW - mammary tumour KW - tretinoin KW - vitamin A acid KW - Non-communicable Human Diseases and Injuries (VV600) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403261&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. AU - Meng XiangJin AU - Dea, S. AU - Engle, R. E. AU - Friendship, R. AU - Lyoo, Y. S. AU - Sirinarumitr, T. AU - Urairong, K. AU - Wang Dong AU - Wong, D. AU - Yoo DongWan AU - Zhang YanJin AU - Purcell, R. H. AU - Emerson, S. U. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1999/// VL - 59 IS - 3 SP - 297 EP - 302 SN - 0146-6615 AD - Meng XiangJin: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 19992216200. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science N2 - To assess the potential of pigs to serve as a global reservoir of hepatitis E virus (HEV), we measured the prevalence of HEV antibodies in pigs in two countries where hepatitis E is endemic (China and Thailand) and two countries where it is not (Korea Republic and Canada). 82 serum samples were taken from pigs in Beijing, China, together with 11 samples from pig handlers and 31 from blood donors. 75 serum samples were taken from pigs from Thailand together with those from 7 pig handlers. 140 serum samples were taken from pigs in Korea Republic. 400 serum samples were taken from pigs in Quebec, Canada, together with 312 serum samples from nursery pigs and a mixture of gilts and sows in Ontario. Swine herds in all 4 countries contained many pigs that were seropositive for IgG anti-HEV, although the percentage of seropositive pigs varied greatly from herd to herd. Most of the pig handlers in the 2 endemic countries were seropositive for HEV. It is suggested that HEV is enzootic in pigs regardless of whether HEV is endemic in the respective human population. KW - disease prevalence KW - disease surveys KW - epidemiology KW - horse diseases KW - human diseases KW - reservoir hosts KW - seroprevalence KW - viral diseases KW - zoonoses KW - Beijing KW - Canada KW - China KW - Korea Republic KW - Ontario KW - Quebec KW - Thailand KW - hepatitis E virus KW - horses KW - man KW - pigs KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Equus KW - Equidae KW - Perissodactyla KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Sus scrofa KW - Sus KW - Suidae KW - Suiformes KW - Artiodactyla KW - Northern China KW - China KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - Commonwealth of Nations KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Threshold Countries KW - Canada KW - ASEAN Countries KW - South East Asia KW - animal reservoirs KW - disease surveillance KW - hogs KW - Peking KW - People's Republic of China KW - South Korea KW - swine KW - viral infections KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992216200&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - High prevalence of TT virus (TTV) infection in patients on maintenance hemodialysis: frequent mixed infections with different genotypes and lack of evidence of associated liver disease. AU - Forns, X. AU - Hegerich, P. AU - Darnell, A. AU - Emerson, S. U. AU - Purcell, R. H. AU - Bukh, J. JO - Journal of Medical Virology JF - Journal of Medical Virology Y1 - 1999/// VL - 59 IS - 3 SP - 313 EP - 317 SN - 0146-6615 AD - Forns, X.: Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 20002007030. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 9007-49-2. N2 - Recently, a novel DNA virus, TT virus (TTV), was identified in patients with post-transfusion non-A-G hepatitis. The authors analysed the prevalence and clinical implications of TTV infection in a cohort of 96 Spanish patients on long-term haemodialysis. TTV DNA was detected by nested PCR in 51 (53%) of 96 patients, a prevalence significantly higher than that found in healthy blood donors. Persistent liver test abnormalities were found in only 2 (7.7%) of 26 patients infected with TTV alone, compared with 12 (75%) of 16 patients infected with hepatitis C or hepatitis B virus, or both (P < 0.01). Mixed infections with multiple strains of TTV, including different major genotypes, were common in patients on haemodialysis. These patients had received a significantly greater number of blood units (22.7 ± 20) compared with patients apparently infected with a single strain of TTV (8.9 ± 11) (P = 0.01). Phylogenetic analyses of TTV from infected patients identified strains of genotypes 1, 2, 3, and 4. In summary, TTV infection was common in patients on haemodialysis but was not associated with liver disease. KW - blood donors KW - clinical aspects KW - disease prevalence KW - DNA KW - epidemiology KW - genotypes KW - haemodialysis KW - hepatitis B KW - hepatitis C KW - human diseases KW - liver diseases KW - mixed infections KW - strains KW - Spain KW - hepatitis B virus KW - hepatitis C virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - Circinoviridae KW - clinical picture KW - deoxyribonucleic acid KW - hemodialysis KW - multiple infections KW - transfusion transmitted virus KW - TT virus KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007030&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Challenges of and strategies for changing prescribing practices of health care providers. AU - Horowitz, A. M. JO - Journal of Public Health Dentistry JF - Journal of Public Health Dentistry Y1 - 1999/// VL - 59 IS - 4 SP - 275 EP - 281 CY - Portland; USA PB - American Association of Public Health Dentistry (AAPHD) SN - 0022-4006 AD - Horowitz, A. M.: Office of Science Policy and Analysis, National Institute of Dental and Craniofacial Research, National Institutes of Health, 45 Center Drive, MSC 6501, 45/3AN-44B, Bethesda, MD 20892-6401, USA. N1 - Accession Number: 20003006554. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 59 ref. Registry Number: 16984-48-8. Subject Subsets: Human Nutrition N2 - Problems related to inappropriate prescribing practices of physicians in general are well recognized. Dietary fluoride supplements have been implicated as one of the contributing factors in an increase in dental fluorosis. Inappropriate prescribing practices of providers have been cited as a major factor in this implication. Numerous studies of physicians and dentists have documented a lack of knowledge and inappropriate prescribing practices regarding fluoride supplements. The purpose of this paper is to identify barriers to changing fluoride-prescribing practices of health care providers and to suggest strategies for implementing change. To increase optimal and appropriate use of fluoride supplements, educational interventions are necessary for all user groups - detail men and women, physicians, dentists, pharmacists, nurse practitioners, dental hygienists, and the public. In addition, environmental supports for the educational activities in the form of policy, regulation, standards of care, and guidelines are recommended for consideration. KW - education KW - fluoride KW - health care workers KW - physicians KW - prescriptions KW - supplements KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - doctors KW - United States of America KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003006554&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-Δ32 mutation. AU - Dean, M. AU - Jacobson, L. P. AU - McFarlane, G. AU - Margolick, J. B. AU - Jenkins, F. J. AU - Howard, O. M. Z. AU - Dong HuiFang AU - Goedert, J. J. AU - Buchbinder, S. AU - Gomperts, E. AU - Vlahov, D. AU - Oppenheim, J. J. AU - O'Brien, S. J. AU - Carrington, M. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1999/// VL - 59 IS - 15 SP - 3561 EP - 3564 SN - 0008-5472 AD - Dean, M.: Laboratories of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 20002007716. Publication Type: Journal Article. Language: English. Number of References: 29 ref. N2 - Non-Hodgkin's lymphoma (NHL) has been increasing in frequency in the industrialized world, but the environmental and genetic factors that contribute to susceptibility are not known. B-cell lymphomas represent a major cause of morbidity and mortality in HIV-infected individuals. The identification of a deletion in the CCR5 chemokine receptor gene that alters the risk for infection and progression to AIDS led to an examination of the potential role of this gene in AIDS lymphoma. A matched case-control analysis was performed using all eligible NHL cases in the Multicenter AIDS Cohort Study. Patients were matched for age, study center, time AIDS-free, and slope of the CD4+ T-cell decline. The CCR5-Δ32 allele was associated with a 3-fold lower risk of NHL among individuals after controlling for time of infection and progression toward AIDS. The CCR5 gene was not associated with a difference in risk for Kaposi's sarcoma, or opportunistic infections. Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells. Taken together, these findings suggest that the CCR5 gene plays a role in the risk of NHL in HIV-infected patients, perhaps through a mechanism involving a decreased response of B cells to the mitogenic activity of RANTES. KW - acquired immune deficiency syndrome KW - B lymphocytes KW - disease course KW - genetics KW - human diseases KW - human immunodeficiency viruses KW - Kaposi's sarcoma KW - lymphocyte transformation KW - morbidity KW - mutations KW - non-Hodgkin's lymphoma KW - opportunistic infections KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - B cells KW - disease progression KW - human immunodeficiency virus KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007716&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Retinoid metabolism in the prostate: effects of administration of the synthetic retinoid N -(4-hydroxyphenyl)retinamide. AU - Lewis, K. C. AU - Hochadel, J. F. JO - Cancer Research (Baltimore) JF - Cancer Research (Baltimore) Y1 - 1999/// VL - 59 IS - 23 SP - 5947 EP - 5955 SN - 0008-5472 AD - Lewis, K. C.: Basic Research Laboratory, Division of Basic Sciences [K. C. L.] and Intramural Research Support Program, Science Applications International Corporation-Frederick [J. F. H.] National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 20001411414. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition N2 - A series of complementary in vivo and in vitro studies have been carried out to better understand the metabolism of retinol by the prostate gland. Male Sprague-Dawley rats were fed either a control diet sufficient in vitamin A (CON group; 0.8 µg retinol equivalents (RE)/g diet) or a CON diet supplemented with the synthetic retinoid N-(4-hydroxyphenyl)-retinamide (4-HPR; CON plus 4HPR group; 1173 µg of 4-HPR/g diet). After an i.v. injection of a physiological radiolabelled dose of retinol, the retinol content and radioactivity of plasma and a number of tissues, including the prostate glands, were monitored for time periods ranging between 30 min and 41 days. On the basis of the results of these retinol turnover studies, tissue subsystem models were developed to describe retinol dynamics in the prostates of both the CON and CON plus 4HPR groups. There was a gradual decrease in the retinol content of the prostates of the 4-HPR-treated group as compared with the control, such that by the end of the study period, the CON plus 4HPR group averaged 0.166±0.0827 (mean±SD) REs, whereas the CON group was 0.732±0.190 REs. The fraction of retinol exiting the prostate each day was not significantly different in the CON as compared with the CON plus 4HPR group (0.149±0.103 vs 0.155±0.191 h (mean±FSD), respectively); however, the average amount of retinol turning over from the CON plus 4HPR group prostates (0.0885 µg/day) was nearly three times less than that of the CON group (0.243 µg/day). To obtain more detailed information on the mechanisms that might be involved in the changes in retinol kinetics observed in the in vivo studies, both a normal human prostate cell line (PrEC) and a human prostate adenocarcinoma cell line (LNCaP) were used to monitor in vitro retinol and 4-HPR dynamics. Cells were treated with 4-HPR for different time periods up to 48 h (PrEC) or 96 h (LNCaP). Retinol in the media was taken up readily by both PrEC and LNCaP cells, and there was conversion of retinol to the major storage esters of vitamin A, retinyl palmitate and retinyl stearate, as well as several minor retinyl esters, in a pattern indicative of normal retinoid esterification activity. Although 4-HPR was taken up readily and over time accumulated in both cell lines, conversion of 4-HPR to its major metabolite, N-[4-methoxyphenyl]retinamide, as well as several other metabolites of 4-HPR was apparent only in the LNCaP cells. The findings would suggest that a study design that includes appropriately designed complementary in vivo and in vitro experimental systems represents a useful approach to better understanding possible mechanisms involved in basic retinoid functioning and interactions in the prostate as well as in other organs and related tissue culture systems. KW - animal models KW - cells KW - diet KW - in vitro KW - metabolism KW - prostate KW - retinol KW - retinyl esters KW - supplements KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001411414&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Linkage of a gene causing malaria refractoriness to Diphenol oxidase-A2 on chromosome 3 of Anopheles gambiae. AU - Romans, P. AU - Black, W. C., IV AU - Sakai, R. K. AU - Gwadz, R. W. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1999/// VL - 60 IS - 1 SP - 22 EP - 29 SN - 0002-9637 AD - Romans, P.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990501643. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 63-84-5, 8049-97-6. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - An inbred line of A. gambiae is refractory to development of malaria parasites. It is homozygous for a 4.3-kb Sal I restriction fragment at the Dox-A2 locus, whereas the parent population is polymorphic at this locus, and a susceptible line is homozygous for an alternate 3.85-kb fragment. The Dox-A2 locus is located in the middle of chromosome 3R, in division 33B, and is tightly linked to a cluster of genes including Dopa decarboxylase that are involved in the production of melanin. Because the refractoriness phenotype, melanotic encapsulation of ookinete/oocysts, might involve activation of or alteration in one or more of these genes, the authors performed genetic crosses to determine whether a previously identified Plasmodium cynomolgi strain Ceylon refractoriness gene, Pif-C, is linked to Dox-A2. Backcross mosquitoes fed on one infected monkey (Macaca mulatta) developed infections of ≤100 oocysts. About 50% of these mosquitoes appeared phenotypically refractory, as expected for the backcross performed, but gave slight evidence of linkage between a refractoriness gene and Dox-A2. In contrast, females fed on a monkey that yielded higher infection levels, up to >300 oocysts, showed clear evidence of linkage between a refractoriness gene and Dox-A2. It was concluded that this Dox-A2-linked refractoriness gene is expressed under conditions particular to the higher infection levels, or that environmental factors obscured the genetic effect of this gene at lower infection levels. KW - chromosomes KW - disease vectors KW - DOPA KW - genes KW - genetics KW - inbred lines KW - infections KW - linkage KW - melanins KW - oocysts KW - parasites KW - phenotypes KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Macaca mulatta KW - monkeys KW - Plasmodium cynomolgi KW - protozoa KW - Anopheles KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Macaca KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - 3,4-dihydroxyphenylalanine KW - diphenol oxidase KW - mosquitoes KW - pure lines KW - refractoriness KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990501643&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Exposure received from application of animal insecticides. AU - Stewart, P. AU - Fears, T. AU - Nicholson, H. F. AU - Kross, B. C. AU - Ogilvie, L. K. AU - Zahm, S. H. AU - Ward, M. H. AU - Blair, A. JO - American Industrial Hygiene Association Journal JF - American Industrial Hygiene Association Journal Y1 - 1999/// VL - 60 IS - 2 SP - 208 EP - 212 SN - 0002-8894 AD - Stewart, P.: Division of Cancer Etiology and Genetics, National Cancer Institute, EPS Room 8102, 6120 Executive Blvd., MSC 7240, Bethesda, MD 20892-7240, USA. N1 - Accession Number: 19990504374. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 33089-61-1, 2921-88-2, 52-85-7, 55-38-9, 52645-53-1, 732-11-6, 51-03-6. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology N2 - Part of an investigation of data collection methods in epidemiologic studies of farmers evaluated exposures received by farmers from the application of insecticides to animals. 20 farmers were monitored during a normal application using a fluorescent dye surrogate for the active ingredient (AI). Insecticides tested were phosmet, amitraz, piperonyl butoxide, famphur, permethrin, chlorpyrifos and fenthion. Two exposure measures were estimated, AI concentration and the time-weighted average for the application period (TWAa). Four application methods were used: high- (n=5) and low-pressure (n=3) spraying, backpack (n=2) and pour-on (n=10). The 2 farmers using a backpack sprayer had nondetectable levels of dye. Only 2 of the farmers using the pour-on method had detectable dye levels, but these levels were high. All of the low- and high-pressure sprayers had detectable amounts of dye. Multiple layers of clothing, gloves, and boots (n=10) were associated with a low mean AI concentration for the exposed farmers (18 µg) and more than 2-thirds of the farmers wearing this amount of clothing had nondetectable exposures. In contrast, clothing providing little or no protection was associated with a significantly higher (P<0.01) average AI concentration (4420 µg), and less than a third of the farmers with this degree of protection had nondetectable exposures. Poor work practices (leaking equipment, contact with wet animals or fences, and back splash) were associated with statistically higher exposure levels (P<0.01) than the absence of such practices. There was a moderate statistically significant association between AI concentration and TWAa with total volume of the AI/dye/water mixture using the Spearman coefficient. Time was significantly inversely proportional to the 2 exposure measures. The association between the 2 exposure measures and AI volume was not significant. KW - amitraz KW - application methods KW - chlorpyrifos KW - clothing KW - exposure KW - famphur KW - farmers KW - fenthion KW - formamidine insecticides KW - livestock KW - nontarget effects KW - occupational hazards KW - organophosphorus insecticides KW - permethrin KW - phosmet KW - piperonyl butoxide KW - pour-on formulations KW - pyrethroid insecticides KW - spraying KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - apparel KW - chlorpyrifos-ethyl KW - clothes KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504374&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Long-term persistence of cellular hyporesponsiveness to filarial antigens after clearance of microfilaremia. AU - Ramya Gopinath AU - Hanna, L. E. AU - Kumaraswami, V. AU - Pillai, S. V. P. AU - Kavitha, V. AU - Vijayasekaran, V. AU - Rajasekharan, A. AU - Nutman, T. B. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1999/// VL - 60 IS - 5 SP - 848 EP - 853 SN - 0002-9637 AD - Ramya Gopinath: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990805163. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 90-89-1, 1642-54-2, 9008-11-1, 70288-86-7. Subject Subsets: Helminthology N2 - The persistence of parasite-specific cellular hyporesponsiveness after clearance of Wuchereria bancrofti blood microfilariae (mff) was studied in 18 individuals in Tamil Nadu, India, who had been treated with a single dose of ivermectin, diethylcarbamazine, or a combination 2-3 years previously and who had initially cleared their parasitaemia. At recruitment into the study, 50% were again mff+ and 50% remained mff-. There were no significant differences between the mff+ and mff- groups in the amount of IFN-γ produced by peripheral blood mononuclear cells in response to adult or microfilarial antigens, although IFN-γ production in response to purified protein derivative was greater in the mff+ group (geometric mean (gm) =3791 pg/ml; P=0.02) than in the mff- group (gm=600 pg/ml). It is suggested that although microfilaraemic individuals may temporarily regain the ability to produce IFN-γ to parasite antigens post-treatment, they subsequently revert to a state of hyporesponsiveness to mff-containing antigens that appears to be independent of the recurrence of microfilaraemia and the response to nonparasite antigens. KW - anthelmintics KW - diethylcarbamazine KW - drug therapy KW - helminths KW - human diseases KW - immune response KW - interferon KW - ivermectin KW - microfilariae KW - parasites KW - persistence KW - India KW - Tamil Nadu KW - man KW - Wuchereria bancrofti KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Wuchereria KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - India KW - chemotherapy KW - immunity reactions KW - immunological reactions KW - Madras KW - nematodes KW - parasitic worms KW - Secernentea KW - Spirurida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805163&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for widespread infection of wild rats with hepatitis E virus in the United States. AU - Kabrane-Lazizi, Y. AU - Fine, J. B. AU - Elm, J. AU - Glass, G. E. AU - Higa, H. AU - Diwan, A. AU - Gibbs, C. J., Jr. AU - Meng XiangJin AU - Emerson, S. U. AU - Purcell, R. H. JO - American Journal of Tropical Medicine and Hygiene JF - American Journal of Tropical Medicine and Hygiene Y1 - 1999/// VL - 61 IS - 2 SP - 331 EP - 335 SN - 0002-9637 AD - Kabrane-Lazizi, Y.: Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990506397. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 308067-58-5, 308067-57-4. N2 - Hepatitis E is an important medical pathogen in many developing countries but is rarely reported from the USA, although antibody to hepatitis E virus (anti-HEV) is found in >1% of US citizens. Zoonotic spread of the virus is suspected. Sera obtained from 239 wild rats (Rattus norvegicus, R. rattus and R. exulans) trapped in widely separated regions of the USA were tested for anti-HEV. 77% of rats from Maryland (in 1997), 90% from Hawaii (in 1986) and 44% from Louisiana (in 1995) were seropositive for anti-HEV. Rats from urban as well as rural areas were seropositive, and the prevalence of anti-HEV IgG increased in parallel with the estimated age of the rats, leading to speculation that they might be involved in the puzzling high prevalence of anti-HEV among some US city dwellers. The discovery of anti-HEV in rats in the USA and the recently reported discovery that HEV is endemic in US swine raise many questions about transmission, reservoirs and strains of HEV in developed countries. KW - antibodies KW - epidemiology KW - hosts KW - IgG KW - IgM KW - immunoglobulins KW - introduced species KW - pests KW - reservoir hosts KW - rural areas KW - serological surveys KW - small mammals KW - urban areas KW - wild animals KW - zoonoses KW - Hawaii KW - Louisiana KW - Maryland KW - USA KW - hepatitis E virus KW - rats KW - Rattus KW - Rattus exulans KW - Rattus norvegicus KW - Rattus rattus KW - Hepatitis E-like viruses KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Murinae KW - Rattus KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Polynesia KW - Oceania KW - Pacific Islands KW - Delta States of USA KW - Southern States of USA KW - Gulf States of USA KW - West South Central States of USA KW - South Atlantic States of USA KW - animal reservoirs KW - black rat KW - brown rat KW - exotic organisms KW - exotic species KW - gamma-globulins KW - immune globulins KW - introduced organisms KW - non-indigenous organisms KW - non-indigenous species KW - non-native organisms KW - non-native species KW - nonindigenous organisms KW - nonindigenous species KW - Norway rat KW - seroepidemiology KW - ship rat KW - United States of America KW - vermin KW - zoonotic infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506397&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vismiaphenones D-G, new prenylated benzophenones from Vismia cayennensis. AU - Fuller, R. W. AU - Westergaard, C. K. AU - Collins, J. W. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1999/// VL - 62 IS - 1 SP - 67 EP - 69 SN - 0163-3864 AD - Fuller, R. W.: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI-FCRDC, Bldg. 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19990302820. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry N2 - Following anti-HIV [human immunodeficiency virus] bioassay-guided fractionation, 4 new prenylated benzophenones, vismiaphenones D-G, were isolated from extracts of leaves of V. cayennensis (collected from Ecuador). Their structures were elucidated by spectral analyses. Only vismiaphenone D exhibited HIV-inhibitory activity. KW - antiviral plants KW - antiviral properties KW - chemical structure KW - fractionation KW - human immunodeficiency viruses KW - phenolic compounds KW - plant composition KW - plant extracts KW - Ecuador KW - plants KW - Vismia KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - eukaryotes KW - Clusiaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - Vismia KW - Andean Group KW - Developing Countries KW - Latin America KW - America KW - South America KW - Threshold Countries KW - anti-viral properties KW - chemical constituents of plants KW - human immunodeficiency virus KW - Vismia cayennensis KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990302820&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii. AU - Fuller, R. W. AU - Blunt, J. W. AU - Boswell, J. L. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1999/// VL - 62 IS - 1 SP - 130 EP - 132 SN - 0163-3864 AD - Fuller, R. W.: National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 19990302826. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Aromatic & Medicinal Plants; Forestry N2 - Bioassay-guided fractionation of extracts of A. stuhlmannii root wood (collected from Tanzania) led to the isolation of a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F. This compound exhibited HIV [human immunodeficiency virus]-inhibitory activity. Its structure was determined from spectral and chemical data. This is the first report of this compound type in the genus Allanblackia. KW - antiviral plants KW - antiviral properties KW - chemical structure KW - fractionation KW - human immunodeficiency viruses KW - medicinal plants KW - plant composition KW - plant extracts KW - Tanzania KW - Clusiaceae KW - plants KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Clusiaceae KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - Allanblackia KW - Allanblackia stuhlmannii KW - anti-viral properties KW - chemical constituents of plants KW - drug plants KW - human immunodeficiency virus KW - medicinal herbs KW - officinal plants KW - Tanganyika KW - Forests and Forest Trees (Biology and Ecology) (KK100) KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990302826&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - 20-O-β-Glucopyranosyl camptothecin from Mostuea brunonis: a potential camptothecin pro-drug with improved solubility. AU - Dai JinRui AU - Hallock, Y. F. AU - Cardellina, J. H., II AU - Boyd, M. R. JO - Journal of Natural Products JF - Journal of Natural Products Y1 - 1999/// VL - 62 IS - 10 SP - 1427 EP - 1429 SN - 0163-3864 AD - Dai JinRui: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick Cancer Research & Development Center, Building 1052, Room 121 Frederick, Maryland 21702-1201, USA. N1 - Accession Number: 20000305167. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants N2 - Bioassay-guided fractionation of the organic extracts of whole plants of M. brunonis, using the National Cancer Institute's (NCI) human tumour-based in vitro antitumour screen, led to the isolation and identification of camptothecin 20-O-β-D-glucoside and 3 moderately cytotoxic alkaloids, the known deoxypumiloside and strictosamide, and the new 2′-O-acetylstrictosamide, from the cytotoxic alkaloid fractions. While the previously unknown 20-O-β-D-glucopyranosyl camptothecin exhibited greater solubility in alcohol, DMSO-H2O and H2O than camptothecin, it was essentially inactive in the NCI's in vitro 60-cell line primary antitumour screen. However, it could be vulnerable to de-glucosidation in vivo, and may, therefore, merit additional evaluation as a potential prodrug of camptothecin that could be more readily formulated than the parent agent. KW - alkaloids KW - cell cultures KW - cytotoxic compounds KW - cytotoxicity KW - in vitro KW - medicinal plants KW - neoplasms KW - quinoline alkaloids KW - solubility KW - Loganiaceae KW - man KW - Gentianales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Loganiaceae KW - cancers KW - drug plants KW - medicinal herbs KW - Mostuea KW - Mostuea brunonis KW - officinal plants KW - Plant Composition (FF040) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000305167&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The p47phox-/- mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs. AU - Segal, B. H. AU - Doherty, T. M. AU - Wynn, T. A. AU - Cheever, A. W. AU - Sher, A. AU - Holland, S. M. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 4 SP - 1659 EP - 1665 SN - 0019-9567 AD - Segal, B. H.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, 10 Center Dr., Dr. MSc. 1886, Bethesda, MD 20892, USA. N1 - Accession Number: 19990803626. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Helminthology N2 - It was hypothesized that abnormal granulomata in patients with chronic granulomatous disease (CGD) may result from aberrant T-cell-mediated cytokine responses. To assess Th-1-type cytokine responses and granulomata, p47phox-/- and wild-type mice were challenged with avirulent (SmD) or virulent (SmT) variants of Mycobacterium avium 2-151. To assess Th-2-type cytokine responses and granulomata, Schistosoma mansoni eggs (SME) were used. Mononuclear cells were harvested, and cytokine responses were determined by ELISA or reverse transcriptase PCR. Following SmD or SmT challenge, splenocytes from p47phox-/- and wild-type mice generated similar polar Th-1 responses (increased levels of interferon-γ and basal levels of IL-4 and IL-5). By 8 weeks after SmT challenge, exuberant splenic granulomata developed in p47phox-/- and wild-type mice. After SME challenge, thoracic lymph node mononuclear cells from p47phox-/- and wild-type mice generated similar mixed Th-1 and Th-2 cytokine responses to SME antigen and concanavalin A. Peak lung granuloma sizes and rates of regression were similar in p47phox-/- and wild-type mice. It is suggested that exuberant granulomatous inflammation in CGD is probably not the result of skewing of T-cell responses toward the Th-1 or Th-2 pole. KW - animal models KW - cytokines KW - disease models KW - genetic disorders KW - granuloma KW - helminth ova KW - helminths KW - immune response KW - interleukins KW - laboratory animals KW - lungs KW - lymph nodes KW - parasites KW - T lymphocytes KW - mice KW - Mycobacterium avium KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacterium KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - bacterium KW - chronic granulomatous disease KW - genetic defects KW - hereditary defects KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803626&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment. AU - Cheever, A. W. AU - Poindexter, R. W. AU - Wynn, T. A. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 5 SP - 2201 EP - 2208 SN - 0019-9567 AD - Cheever, A. W.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990804912. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9008-11-1, 207137-56-2, 308079-78-9, 148157-34-0. Subject Subsets: Helminthology N2 - Egg laying by Schistosoma mansoni and S. japonicum was delayed in severe combined immunodeficiency (SCID) mice, but in a matter of weeks worm fecundity was equivalent to that in intact mice. SCID mice formed smaller hepatic granulomas and showed less fibrosis than did intact mice. The reduction in egg-associated pathology in SCID mice correlated with marked reductions in IL-4, IL-5, IL-13 and gamma interferon mRNA expression in the liver. S. mansoni infections were frequently lethal for SCID mice infected for more than 9 weeks, whereas S. japonicum-infected SCID mice died at the same rate as infected intact mice. Hepatic granuloma formation and egg laying by worms in SCID mice was unaffected by administration of recombinant murine tumour necrosis factor alpha (TNF-α). In fact, SCID and BALB/c mice appeared to express nearly equivalent levels of TNF-α mRNA in their granulomatous tissues, suggesting that there is little or no deficit in TNF-α expression in infected SCID mice. The data indicate that TNF-α may be in large part derived from a non-T-cell source. Together, these findings provide little evidence that TNF-α alone can reconstitute early fecundity, granuloma formation, or hepatic fibrosis in schistosome-infected SCID mice. KW - cytokines KW - experimental infections KW - fecundity KW - helminths KW - hepatic fibrosis KW - immunocompromised hosts KW - immunopathology KW - interferon KW - interleukin 13 KW - interleukin 4 KW - interleukin 5 KW - laboratory animals KW - parasites KW - pathology KW - SCID mice KW - T lymphocytes KW - tumour necrosis factor KW - mice KW - Schistosoma japonicum KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - cachectin KW - cachexin KW - granulomata KW - immunopathogenesis KW - parasitic worms KW - severe combined immunodeficiency KW - Strigeida KW - T cells KW - tumor necrosis factor KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804912&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers. AU - Kotake, S. AU - Schumacher, H. R., Jr. AU - Arayssi, T. K. AU - Gérard, H. C. AU - Branigan, P. J. AU - Hudson, A. P. AU - Yarboro, C. H. AU - Klippel, J. H. AU - Wilder, R. L. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 5 SP - 2682 EP - 2686 SN - 0019-9567 AD - Kotake, S.: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992007603. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9008-11-1, 130068-27-8. Subject Subsets: Public Health N2 - The synovial expression of interleukin-10 (IL-10) and gamma interferon (IFN-γ) and additional cytokine genes was examined in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-γ mRNA were relatively abundant in recent-onset Chl-AA. KW - arthritis KW - cytokines KW - gene expression KW - human diseases KW - immune response KW - interferon KW - interleukin 10 KW - Chlamydia KW - man KW - Chlamydiaceae KW - Chlamydiales KW - Chlamydiae KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - bacterium KW - immunity reactions KW - immunological reactions KW - synovial membranes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007603&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effects of environmental pH on membrane proteins in Borrelia burgdorferi. AU - Carroll, J. A. AU - Garon, C. F. AU - Schwan, T. G. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 7 SP - 3181 EP - 3187 SN - 0019-9567 AD - Carroll, J. A.: Rocky Mountain Laboratories Microscopy Branch, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. N1 - Accession Number: 20000507029. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Medical & Veterinary Entomology N2 - Borrelia burgdorferi, the causative agent of Lyme disease, alternates between the microenvironments of the tick vector, Ixodes scapularis, and a mammalian host. The environmental conditions the spirochaete encounters during its infectious cycle are suspected to differ greatly in many aspects, including available nutrients, temperature, and pH. Here we identify alterations in the membrane protein profile, as determined by immunoblotting and two-dimensional nonequilibrium pH gradient gel electrophoresis (2D-NEPHGE), that occur in virulent B. burgdorferi B31 as the pH of the medium is altered. Initial comparisons of cultures incubated at pH 6.0, 7.0, and 8.0 yielded alterations in the expression of seven membrane proteins as determined by probing with hyperimmune rabbit serum. Six of these membrane proteins (54, 45, 44, 43, 35, and 24 kDa) were either present in increased amounts in or solely expressed by cultures incubated at pH 6.0 and 7.0. The 24-kDa protein that decreased in expression at pH 8.0 was identified as outer surface protein C (OspC). In addition, a 42-kDa membrane protein increased in amount in cultures incubated at pH 8.0. Similar changes were observed with serum from a mouse infected by tick bite, with the recognition of two additional bands (48 and 46 kDa) unique to pH 6.0 and 7.0. When membrane fractions were analysed by 2D-NEPHGE, at least 37 changes in the membrane protein profile between cells incubated at pH 6.0, 7.0, and 8.0 were observed by immunoblotting and silver staining. Environmental cues such as pH may prove important in the regulation of virulence determinants and factors necessary for the adaptation of B. burgdorferi to the tick or mammalian microcosm. KW - human diseases KW - in vitro KW - Lyme disease KW - pH KW - surface proteins KW - virulence KW - Borrelia burgdorferi KW - Borrelia KW - Spirochaetaceae KW - Spirochaetales KW - Spirochaetes KW - Bacteria KW - prokaryotes KW - bacterium KW - hydrogen ion concentration KW - lyme borreliosis KW - membrane proteins KW - potential of hydrogen KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000507029&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam. AU - Kossaczka, Z. AU - Lin FengYing AU - Vô AnhHo AU - Nguyen Thi Thanh Thuy AU - Phan Van Bay AU - Tran Cong Thanh AU - Ha Ba Khiem AU - Dang Duc Trach AU - Karpas, A. AU - Hunt, S. AU - Bryla, D. A. AU - Schneerson, R. AU - Robbins, J. B. AU - Szu, S. C. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 11 SP - 5806 EP - 5810 SN - 0019-9567 AD - Kossaczka, Z.: National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20002008450. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 308067-58-5. N2 - The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi conjugate vaccines were evaluated in adults, 5- to 14-year-old children, and 2- to 4-year-old children in Vietnam. The conjugates were prepared with Pseudomonas aeruginosa recombinant exoprotein A (rEPA) as the carrier, using either N-succinimidyl-3-(2-pyridyldithio)-propionate (SPDP; Vi-rEPA1) or adipic acid dihydrazide (ADH; Vi-rEPA2) as linkers. None of the recipients experienced a temperature of >38.5°C or significant local reactions. One injection of Vi-rEPA2 into adults elicited a geometric mean (GM) increase in anti-Vi immunoglobulin G (IgG) from 9.62 enzyme-linked immunosorbent assay units/ml (EU) to 465 EU at 6 weeks; this level fell to 119 EU after 26 weeks. In the 5- to 14-year-old children, anti-Vi IgG levels at 6 weeks elicited by Vi-rEPA2, Vi-rEPA1, and Vi were 169, 22.8, and 18.9 EU, respectively (P = 0.0001 for Vi-rEPA1 and Vi with respect to Vi-rEPA2). At 26 weeks, the anti-Vi IgG levels for recipients of Vi-rEPA2, Vi-rEPA1, and Vi were 30.0, 10.8, and 13.4 EU, respectively (P < 0.001 for Vi-rEPA1 and Vi with respect to Vi-rEPA2); all were higher than the preinjection levels (P = 0.0001). Vi-rEPA2 also elicited the highest anti-Vi IgM and IgA levels of the three vaccines. In the 2- to 4-year-old children at 6 weeks following the first injection, Vi-rEPA2 elicited an anti-Vi IgG level of 69.9 EU compared to 28.9 EU for Vi-rEPA1 (P = 0.0001). Reinjection increased Vi antibody levels from 69.9 to 95.4 EU for Vi-rEPA2 and from 28.9 to 83.0 EU for Vi-rEPA1. At 26 weeks, anti-Vi IgG levels remained higher than those at preinjection (30.6 versus 0.18 for Vi-rEPA2 and 12.8 versus 0.33 for Vi-rEPA1; P = 0.0001 for both). Vi vaccine is recommended for individuals of 5 years of age or older. In the present study, the GM level of anti-Vi IgG elicited by two injections of Vi-rEPA2 in the 2- to 4-year-old children was higher than that elicited by Vi in the 5- to 14-year-old children (30.6 versus 13.4; P = 0.0001). The safety and immunogenicity of the Vi-rEPA2 conjugate warrant further investigation. KW - adolescents KW - adults KW - children KW - conjugate vaccines KW - disease prevention KW - human diseases KW - IgA KW - IgG KW - IgM KW - immune response KW - safety KW - typhoid KW - Vietnam KW - man KW - Salmonella typhi KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - Indochina KW - South East Asia KW - Asia KW - bacterium KW - immunity reactions KW - immunological reactions KW - teenagers KW - Viet Nam KW - Host Resistance and Immunity (HH600) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002008450&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response. AU - Cooper, P. J. AU - Espinel, I. AU - Wieseman, M. AU - Paredes, W. AU - Espinel, M. AU - Guderian, R. H. AU - Nutman, T. B. JO - Infection and Immunity JF - Infection and Immunity Y1 - 1999/// VL - 67 IS - 11 SP - 5951 EP - 5957 SN - 0019-9567 AD - Cooper, P. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20000804315. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases N2 - To investigate whether helminth infections may affect the efficacy of vaccines by impairing the immune response to nonparasite vaccine antigens, the antibody responses to tetanus toxoid (TT) after tetanus vaccination in 193 subjects with Onchocerca volvulus infection were compared with those of 85 noninfected controls. After vaccination, the proportions of subjects in each group attaining protective levels of antitetanus antibodies were similar (96.9% infected versus 97.6% noninfected). Postvaccination increases in antitetanus IgG and the predominant IgG isotype (IgG1) were equivalent in both groups, as were increases in specific IgG4 and IgE; however, significantly greater increases in specific IgG2 (P<0.05) and IgG3 (P<0.001) were observed in the noninfected group. Stratification of the O. volvulus-infected group into 2 groups representing light and heavy infections revealed a significantly impaired antitetanus IgG response in those with heavy infections compared to those with light infections (P<0.01) or no infection (P<0.05). The impact of concurrent intestinal helminth infections on the antitetanus response was also examined: an increased IgG4/IgE ratio was seen in those infected with Strongyloides stercoralis (P<0.05) and when all helminth infections were combined as a single group (P<0.05). The results indicate that concurrent infection with O. volvulus does not prevent the development of a protective antitetanus response, although heavier O. volvulus infections are able to alter the magnitude of this response and concurrent helminth infections (O. volvulus and intestinal helminths) may alter TT-specific antibody isotype responses. KW - antibodies KW - antigens KW - helminths KW - human diseases KW - IgE KW - IgG KW - immune response KW - immunization KW - immunoglobulins KW - infections KW - interactions KW - isotypes KW - nematode infections KW - onchocerciasis KW - parasites KW - tetanus toxoid KW - vaccines KW - Clostridium tetani KW - man KW - Onchocerca volvulus KW - Rhabditida KW - Strongyloides stercoralis KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - Strongyloides KW - Strongyloididae KW - antigenicity KW - bacterium KW - gamma-globulins KW - immune globulins KW - immune sensitization KW - immunity reactions KW - immunogens KW - immunological reactions KW - nematodes KW - onchocercosis KW - parasitic worms KW - reagin KW - reaginic antibodies KW - river blindness KW - Secernentea KW - Spirurida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804315&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Photophysical studies on antimalarial drugs. AU - Motten, A. G. AU - Martínez, L. J. AU - Holt, N. AU - Sik, R. H. AU - Reszka, K. AU - Chignell, C. F. AU - Tonnesen, H. H. AU - Roberts, J. E. JO - Photochemistry and Photobiology JF - Photochemistry and Photobiology Y1 - 1999/// VL - 69 IS - 3 SP - 282 EP - 287 SN - 0031-8655 AD - Motten, A. G.: National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA. N1 - Accession Number: 19990808168. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 69-44-3, 86-42-0, 50-63-8, 54-05-7, 132-73-0, 64-17-5, 51773-92-3, 53230-10-7, 69-05-6, 82-89-6, 63-45-6, 90-34-6, 549-56-4, 60-93-5, 6119-70-6, 130-89-2, 130-95-0, 118-42-3. Subject Subsets: Protozoology N2 - Most drugs used in the treatment of malaria produce phototoxic side effects in both the skin and the eye. Cutaneous and ocular effects that may be caused by light include changes in skin pigmentation, corneal opacity, cataract formation and other visual disturbances including irreversible retinal damage (retinopathy) leading to blindness. The mechanism for these reactions is unknown. A number of antimalarial drugs (amodiaquine, chloroquine, hydroxychloroquine, mefloquine, primaquine and quinacrine) were irradiated with light (λ >300 nm) and electron paramagnetic resonance (EPR) and laser flash photolysis studies were conducted to determine the possible active intermediates produced. Each drug produced at least one EPR adduct with the spintrap 5,5-dimethyl-1-pyrroline N-oxide in benzene: superoxide/hydroperoxyl adducts (chloroquine, mefloquine, quinacrine, amodiaquine and quinine), carbon-centred radical adducts (all but primaquine), or a nitrogen-centred radical adduct only (primaquine). In ethanol all drugs except primaquine produced some superoxide/hydroperoxyl adduct, with quinine, quinacrine and hydroxychloroquine also producing the ethoxyl adduct. As detected with flash photolysis and steady-state techniques, mefloquine, quinine, amodiaquine and a photoproduct of quinacrine produced singlet oxygen (φΔ=0.38; φΔ=0.36; φΔ=0.011; φΔ=0.013 in D2O, pD7), but only primaquine quenched singlet oxygen efficiently (2.6 × 108/M/second in D2O, pD7). Because malaria is most prevalent in regions of high light intensity, protective measures (clothing, sunblock, sunglasses or eye wraps) should be recommended when administering antimalarial drugs. KW - adverse effects KW - amodiaquine KW - antimalarials KW - antiprotozoal agents KW - blindness KW - cataract KW - chloroquine KW - clothing KW - drug toxicity KW - ethanol KW - eye diseases KW - eyes KW - human diseases KW - hydroxychloroquine KW - irradiation KW - light KW - malaria KW - mefloquine KW - mepacrine KW - parasites KW - photolysis KW - phototoxicity KW - pigmentation KW - primaquine KW - quinine KW - retina KW - skin KW - man KW - Plasmodium KW - protozoa KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - adverse reactions KW - apparel KW - clothes KW - dermis KW - ethyl alcohol KW - photodegradation KW - photolytic degradation KW - quinacrine KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990808168&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Report of a National Institutes of Health-Centers for Disease Control and Prevention workshop on the feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons. AU - Yanovski, S. Z. AU - Bain, R. P. AU - Williamson, D. F. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 69 IS - 3 SP - 366 EP - 372 SN - 0002-9165 AD - Yanovski, S. Z.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. N1 - Accession Number: 19991404819. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition N2 - The discussions that took place at the workshop are described and it was agreed that a randomised clinical trial could answer questions necessary for developing a rational clinical and public health policy for treating obesity in the USA. KW - body weight KW - government policy KW - health KW - health policy KW - obesity KW - policy KW - public health KW - weight reduction KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - fatness KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Causal criteria in nutritional epidemiology. AU - Potischman, N. AU - Weed, D. L. A2 - Byers, T. A2 - Dickson, J. H. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 69 IS - 6 SP - 1309S EP - 1314S SN - 0002-9165 AD - Potischman, N.: National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19991410527. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition KW - aetiology KW - cardiovascular diseases KW - diet KW - diet studies KW - diet study techniques KW - dietary guidelines KW - disease prevention KW - epidemiology KW - methodology KW - neoplasms KW - prevention KW - cancers KW - causal agents KW - etiology KW - methods KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410527&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Food and nutrient exposures: what to consider when evaluating epidemiologic evidence. AU - Sempos, C. T. AU - Liu Kiang AU - Ernst, N. D. A2 - Byers, T. A2 - Dickson, J. H. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 69 IS - 6 SP - 1330S EP - 1338S SN - 0002-9165 AD - Sempos, C. T.: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19991410530. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition N2 - An overview of the strengths and limitations of nutritional epidemiology is presented. Study design, dietary survey methodology and interpretation of epidemiologic data and assessment of causality are discussed. KW - cardiovascular diseases KW - diet KW - diet studies KW - diet study techniques KW - diseases KW - epidemiology KW - food consumption KW - foods KW - interpretation KW - methodology KW - neoplasms KW - nutrients KW - nutrition KW - reviews KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - methods KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410530&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - β-Carotene and lung cancer: a case study. AU - Albanes, D. A2 - Byers, T. A2 - Dickson, J. H. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 69 IS - 6 SP - 1345S EP - 1350S SN - 0002-9165 AD - Albanes, D.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19991410689. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition N2 - Available evidence of the relation betweenβ-carotene and lung cancer, including data regarding β-carotene intake (from diet and supplements), β-carotene biochemical status and fruit and vegetable consumption is reviewed. The role of this evidence in making nutrition recommendations is discussed. KW - beta-carotene KW - carotenoids KW - clinical trials KW - consumption KW - diet KW - diet studies KW - dietary guidelines KW - epidemiology KW - fruit KW - lung cancer KW - lungs KW - neoplasms KW - reviews KW - tobacco smoking KW - vegetables KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - tetraterpenoids KW - vegetable crops KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410689&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Energy metabolism in African Americans: potential risk factors for obesity. AU - Weyer, C. AU - Snitker, S. AU - Bogardus, C. AU - Ravussin, E. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 70 IS - 1 SP - 13 EP - 20 SN - 0002-9165 AD - Weyer, C.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. N1 - Accession Number: 19991411313. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition N2 - Recent reports have identified a lower resting metabolic rate in African Americans than in whites, but most studies included only females and used short-term measurements with ventilated-hood systems. Our objective was to compare 24-h measurements of energy metabolism between African American and white women and men using a respiratory chamber. 38 African American (x\+- SD: 3\+- 7 years of age, 24±10% body fat) and 288 white (31±7 years of age, 26±12% body fat) subjects spent 24 h in a respiratory chamber for measurement of 24-h energy expenditure (24EE), sleeping metabolic rate (SMR), 24-h respiratory quotient (24RQ), and substrate oxidation rates. After adjustment for sex, age, and body composition (by hydrodensitometry), African Americans had lower SMR (-301±105 kJ/day; P<0.01) and higher 24RQ (0.014±0.004; P<0.001) than whites, whereas 24EE was similar. A sex-specific analysis, using a subset of 38 whites with an equal sex distribution and similar age and body weight, revealed that African American women had lower SMR (-442±182 kJ/day; P<0.05) and lower 24EE (-580±232 kJ/day; P<0.05), but similar 24RQ values compared with white women. African American men tended to have lower SMRs than white men (-355±188 kJ/day; P=0.07), but had higher 24RQ values, accounting for a 992±327-kJ/day lower 24-h fat oxidation rate (P<0.005). These data not only confirm the findings of a lower metabolic rate in African American than in white women, but also suggest that fat oxidation is lower in African American men than in white men. KW - basal metabolism KW - energy metabolism KW - ethnic groups KW - men KW - metabolism KW - respiratory quotient KW - resting energy exchange KW - sex differences KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - basal energy exchange KW - Physiology of Human Nutrition (VV120) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411313&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genetic and environmental influences on eating patterns of twins aged ≥50 y. AU - Bree, M. B. M. van den AU - Eaves, L. J. AU - Dwyer, J. T. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 70 IS - 4 SP - 456 EP - 465 SN - 0002-9165 AD - Bree, M. B. M. van den: National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, PO Box 5180, Baltimore, MD 21224, USA. N1 - Accession Number: 20001406231. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition N2 - Male and female twins (n=4640) aged ≥50 years completed a mailed version of the National Cancer Institute food-frequency questionnaire. Factor analysis was performed to identify eating patterns among respondents. Estimates of genetic, common environmental (shared by family members), and specific environmental (unique to an individual) influences were obtained for food use, serving size, and consumption frequency by comparing monozygotic and dizygotic twin-pair groups with structural equation analysis. Two independent eating patterns were identified: the first consisted of items high in fat, salt, and sugar, and the second reflected healthful eating habits. Although the influence of environmental factors was larger, between 15 and 38% of the total variation in pattern 1 and between 33 and 40% in pattern 2 were explained by genetic influences. Models accounting for sex differences in genetic and environmental estimates fit the data significantly better for food use and serving size of foods in eating pattern 1 and for food use in eating pattern 2. It is concluded that although 60-85% of the variability in eating patterns was associated with environmental factors, genetic influences were also apparent and there was some evidence of sex specificity. KW - behaviour KW - diet KW - environmental factors KW - feeding behaviour KW - foods KW - genetics KW - nutrients KW - old age KW - sex differences KW - twins KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - behavior KW - feeding behavior KW - United States of America KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406231&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet. AU - Ponnamperuma, R. M. AU - Kirchhof, S. M. AU - Trifiletti, L. AU - Luca, L. M. de JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 70 IS - 4 SP - 502 EP - 508 SN - 0002-9165 AD - Ponnamperuma, R. M.: Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 20001406235. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 302-79-4, 68-26-8. Subject Subsets: Human Nutrition N2 - Female SENCAR mice maintained on a purified retinol-deficient diet containing either 0 or 3 µg retinoic acid/g diet were studied. Mice were either ovariectomized or intact. Squamous cells arising in the normally simple columnar epithelium of the endo cervix and uterine cavity were monitored by keratin 5 expression with immunohistochemistry. Ovariectomy did not change the time to onset of retinol deficiency. It increased the number of squamous metaplastic cells and prolonged survival in mice consuming a retinol-deficient diet by as much as 40%. It is concluded that factors other than epithelial differentiation per se control survival outcome of retinol-deficient mice. The results also show a significant increase in longevity of retinol-deficient mice when ovariectomized. KW - deficiency KW - diet KW - epithelium KW - longevity KW - metaplasia KW - mortality KW - oestrogens KW - ovariectomy KW - retinoic acid KW - retinoids KW - retinol KW - steroids KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - death rate KW - estrogens KW - tretinoin KW - vitamin A KW - vitamin A acid KW - vitamin A alcohol KW - vitamin A compounds KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406235&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Regions of the human brain affected during a liquid-meal taste perception in the fasting state: a positron emission tomography study. AU - Gautier, J. F. AU - Chen KeWei AU - Uecker, A. AU - Bandy, D. AU - Frost, J. AU - Salbe, A. D. AU - Pratley, R. E. AU - Lawson, M. AU - Ravussin, E. AU - Reiman, E. M. AU - Tataranni, P. A. JO - American Journal of Clinical Nutrition JF - American Journal of Clinical Nutrition Y1 - 1999/// VL - 70 IS - 5 SP - 806 EP - 810 SN - 0002-9165 AD - Gautier, J. F.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. N1 - Accession Number: 20001407178. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition N2 - Positron emission tomography (PET) was used to explore regions of the brain that were preferentially affected during the taste perception of a liquid meal by 11 right-handed, lean men in the fasting state. After subjects had fasted for 36 h, 2 measurements of regional cerebral blood flow (rCBF) obtained immediately after subjects retained and swallowed 2 ml of a flavoured liquid meal (the taste condition) were compared with 2 measurements of rCBF obtained immediately after subjects retained and swallowed 2 ml of water (the baseline condition). Taste was associated with increased rCBF (P<0.005) in the left dorsolateral prefrontal cortex and superior temporal gyrus; the right ventrolateral prefrontal cortex, supramarginal gyrus, and anterior thalamus; and bilaterally in the hippocampal formation, posterior cingulate, midbrain, occipital cortex, and cerebellum. Taste was also associated with decreased rCBF (P<0.005) in the right dorsolateral prefrontal cortex, superior temporal gyrus, and supplementary motor area, and bilaterally in the medial prefrontal cortex and inferior parietal lobule. It is concluded that this exploratory study provides additional evidence that the temporal cortex, thalamus, cingulate cortex, caudate, and hippocampal formation are preferentially affected by taste stimulation. The asymmetric pattern of activity in the dorsolateral prefrontal cortex and superior temporal gyrus may contribute to the taste perception of a liquid meal perceived as pleasant. Additional studies are required to determine how these regions are affected in patients with obesity or anorexia. KW - blood flow KW - brain KW - fasting KW - men KW - perception KW - taste KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cerebrum KW - Human Physiology and Biochemistry (VV050) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407178&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Function of a bovine papillomavirus type 1 exonic splicing suppressor requires a suboptimal upstream 3′ splice site. AU - Zheng ZhiMing AU - He PeiJun AU - Baker, C. C. JO - Journal of Virology JF - Journal of Virology Y1 - 1999/// VL - 73 IS - 1 SP - 29 EP - 36 SN - 0022-538X AD - Zheng ZhiMing: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA. N1 - Accession Number: 19992213135. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Veterinary Science N2 - Alternative splicing is an important mechanism for the regulation of bovine papillomavirus type 1 (BPV-1) gene expression during the virus life cycle. Previous studies have identified 2 purine-rich exonic splicing enhancers (ESEs), SE1 and SE2, located between 2 alternative 3′ splice sites at nucleotide (nt) 3225 and nt 3605. Further analysis of BPV-1 late-pre-mRNA splicing in vitro identified a 48-nt pyrimidine-rich region immediately downstream of SE1 that inhibits utilization of the nt 3225 3′ splice site. This inhibitory element, named an exonic splicing suppressor (ESS), has a U-rich 5′ end, a C-rich central part, and an AG-rich 3′ end. The present study utilized in vitro splicing of both homologous and heterologous pre-mRNAs to further characterize the ESS. The BPV-1 ESS was inserted downstream of the 3′ splice site in the BPV-1 late pre-mRNA, Rous sarcoma virus src pre-mRNA, human immunodeficiency virus tat-rev pre-mRNA, and Drosophila dsx pre-mRNA, all containing a suboptimal 3′ splice site, and in the human β-globin pre-mRNA, which contains a constitutive 3′ splice site. The results showed that suppression of splicing by the BPV-1 ESS requires an upstream suboptimal 3′ splice site but not an upstream ESE. Furthermore, the ESS functions when located either upstream or downstream of BPV-1 SE1. Mutational analyses showed that the function of the ESS is sequence dependent and that only the C-rich region of the ESS is essential for suppression of splicing in all the pre-mRNAs tested. KW - enhancers KW - gene expression KW - human immunodeficiency viruses KW - in vitro KW - inhibition KW - neoplasms KW - nucleotide sequences KW - Rous sarcoma KW - sarcoma KW - splicing KW - Drosophila KW - Papillomavirus KW - Rous sarcoma virus KW - viruses KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Drosophilidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Alpharetrovirus KW - avian viral sarcoma KW - bovine papillomavirus KW - cancers KW - DNA sequences KW - human immunodeficiency virus KW - Papovaviridae KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-Communicable Diseases and Injuries of Animals (LL860) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992213135&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a novel simian immunodeficiency virus (SIV) from l'hoest monkeys (Cercopithecus l'hoesti): implications for the origins of SIVmnd and other primate lentiviruses. AU - Hirsch, V. M. AU - Campbell, B. J. AU - Bailes, E. AU - Goeken, R. AU - Brown, C. AU - Elkins, W. R. AU - Axthelm, M. AU - Murphey-Corb, M. AU - Sharp, P. M. JO - Journal of Virology JF - Journal of Virology Y1 - 1999/// VL - 73 IS - 2 SP - 1036 EP - 1045 SN - 0022-538X AD - Hirsch, V. M.: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. N1 - Accession Number: 19990505772. Publication Type: Journal Article. Language: English. Number of References: 50 ref. N2 - The human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) appear to have originated by cross-species transmission of simian immunodeficiency virus (SIV) from asymptomatically infected African primates. Few of the SIVs characterized to date efficiently infect human primary lymphocytes. Interesting, 2 of the 3 identified to infect such cultures (SIVsm and SIVcpz) have appeared in human populations as genetically related HIVs. Here, a novel SIV isolate from the East African monkey, C. l'hoesti, which was designated SIVlhoest was characterized. This SIV isolate efficiently infected both human and macaque lymphocytes and resulted in a persistent infection of macaques [Macaca], characterized by high primary virus load and a progressive decline in circulating CD4 lymphocytes, consistent with progression to AIDS. Phylogenetic analyses showed that SIVlhoest is genetically distinct from other previously characterized primate lentiviruses, but clusters in the same major lineage as SIV from mandrills [Mandrillus sphinx] (SIVmnd), a West African primate species. Given the geographic distance between the ranges of l'hoest monkeys and mandrills, this may indicate that SIVmnd arose through cross-species transmission from close relatives of l'hoest monkeys that are sympatric with mandrills. These observations lend support to the hypothesis that the primate lentiviruses originated and coevolved within monkeys of the Cercopithecus genus. Regarded in this light, lentivirus infections of primates not belonging to the Cercopithecus genus may have resulted from cross-species transmission in the not-too-distant past. The EMBL/GenBank/DDBJ accession number for the SIVlhoest nucleotide sequence is AF075269. KW - acquired immune deficiency syndrome KW - CD4 antigens KW - CD4+ lymphocytes KW - disease course KW - disease transmission KW - experimental infections KW - lymphocytes KW - East Africa KW - Cercopithecus KW - Lentivirus KW - Macaca KW - Mandrillus KW - Mandrillus sphinx KW - monkeys KW - Primates KW - simian immunodeficiency virus KW - Cercopithecidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Lentivirus KW - Mandrillus KW - Africa South of Sahara KW - Africa KW - AIDS KW - CD4 KW - CD4+ cells KW - Cercopithecinae KW - Cercopithecus l'hoesti KW - disease progression KW - T4 lymphocytes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505772&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence. AU - Chabry, J. AU - Priola, S. A. AU - Wehrly, K. AU - Nishio, J. AU - Hope, J. AU - Chesebro, B. JO - Journal of Virology JF - Journal of Virology Y1 - 1999/// VL - 73 IS - 8 SP - 6245 EP - 6250 SN - 0022-538X AD - Chabry, J.: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 20002216868. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Veterinary Science N2 - Conversion of the normal protease-sensitive prion protein (PrP) to its abnormal protease-resistant isoform (PrP-res) is a major feature of the pathogenesis associated with transmissible spongiform encephalopathy (TSE) diseases. In previous experiments, PrP conversion was inhibited by a peptide composed of hamster PrP residues 109 to 141, suggesting that this region of the PrP molecule plays a crucial role in the conversion process. In this study, we used PrP-res derived from animals infected with two different mouse scrapie strains and one hamster scrapie strain to investigate the species specificity of these conversion reactions. Conversion of PrP was found to be completely species specific; however, despite having three amino acid differences, peptides corresponding to the hamster and mouse PrP sequences from residues 109 to 141 inhibited both the mouse and hamster PrP conversion systems equally. Furthermore, a peptide corresponding to hamster PrP residues 119 to 136, which was identical in both mouse and hamster PrP, was able to inhibit PrP-res formation in both the mouse and hamster cell-free systems as well as in scrapie-infected mouse neuroblastoma cell cultures. Because the PrP region from 119 to 136 is very conserved in most species, this peptide may have inhibitory effects on PrP conversion in a wide variety of TSE diseases. KW - prion diseases KW - prion proteins KW - prions KW - scrapie KW - spongiform encephalopathy KW - hamsters KW - mice KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002216868&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. AU - Pevenstein, S. R. AU - Williams, R. K. AU - McChesney, D. AU - Mont, E. K. AU - Smialek, J. E. AU - Straus, S. E. JO - Journal of Virology JF - Journal of Virology Y1 - 1999/// VL - 73 IS - 12 SP - 10514 EP - 10518 SN - 0022-538X AD - Pevenstein, S. R.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Building 10, 11N228, 10 Center Dr., Bethesda, MD 20892, USA. N1 - Accession Number: 20002013316. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2902±1082 (standard error of the mean) or 109 genomes/105 cells, respectively. Eleven of 14 (79%) to 13 of 15 (87%) of the ganglia were PCR positive for VZV gene 29, 31, or 62. Pooling of the results for the three VZV genes yielded a mean of 258±38 genomes/105 ganglion cells. These levels of latent viral genome loads have implications for virus distribution in and reactivation from human sensory ganglia. KW - fluorescence KW - ganglia KW - genes KW - genomes KW - glycoproteins KW - human diseases KW - polymerase chain reaction KW - quantitative techniques KW - Human herpesvirus 1 KW - Human herpesvirus 2 KW - Human herpesvirus 3 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - Varicellovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - herpes simplex virus 1 KW - herpes simplex virus 2 KW - PCR KW - varicella-zoster virus KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002013316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characteristics of pesticide use in a pesticide applicator cohort: the agricultural health study. AU - Alavanja, M. C. R. AU - Sandler, D. P. AU - McDonnell, C. J. AU - Lynch, C. F. AU - Pennybacker, M. AU - Zahm, S. H. AU - Mage, D. T. AU - Steen, W. C. AU - Wintersteen, W. AU - Blair, A. JO - Environmental Research, Section A JF - Environmental Research, Section A Y1 - 1999/// VL - 80 IS - 2 SP - 172 EP - 179 AD - Alavanja, M. C. R.: Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland Z0892, USA. N1 - Accession Number: 19990502463. Publication Type: Journal Article. Language: English. Number of References: 18 ref. N2 - Data were collected during 1994-95 on recent and historic pesticide use, pesticide application methods, and farm characteristics from 35 879 restricted-use pesticide applicators. This represented the first 2 years of the Agricultural Health Study, which is studying a large cohort of private and commercial licensed pesticide applicators in Iowa (which are certified) and North Carolina (which are licensed). In Iowa, commercial applicators apply pesticides more frequently per year than private applicators in either state. Iowa private and Iowa commercial applicators tended to use the same type of pesticides (r² = 0.88). White and non-white private applicators tended to use the same type of pesticides (r² = 0.89) as did male and female private applicators (Iowa r² = 0.85 and North Carolina r² = 0.84). There was less similarity between the types of pesticides used in Iowa and North Carolina private applicators. A greater proportion of Iowa private applicators used personal protective equipment than in North Carolina, and pesticide application methods varied by state. KW - application methods KW - applicators KW - insecticides KW - pest control KW - pesticides KW - protective clothing KW - usage KW - Iowa KW - North Carolina KW - USA KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Appalachian States of USA KW - Southern States of USA KW - South Atlantic States of USA KW - United States of America KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502463&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characteristics of persons who self-reported a high pesticide exposure event in the agricultural health study. AU - Alavanja, M. C. R. AU - Sandler, D. P. AU - McDonnell, C. J. AU - Mage, D. T. AU - Kross, B. C. AU - Rowland, A. S. AU - Blair, A. JO - Environmental Research, Section A JF - Environmental Research, Section A Y1 - 1999/// VL - 80 IS - 2 SP - 180 EP - 186 AD - Alavanja, M. C. R.: Epidemiology and Biostatistics Program, National Cancer Institute, 6130 Executive Boulevard, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991103614. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Agricultural Entomology; Weeds N2 - Data on pesticide application practices and health were obtained from a cohort of licensed pesticide applicators from Iowa and North Carolina, USA, 14% of whom reported having high pesticide exposure events (HPEEs). Females, applicators from North Carolina and private applicators were at lower risk from an HPEE. Pesticide applicators with an HPEE were more likely to delay changing their work clothing after pesticide application, mix their work clothing with the family wash, delay washing until the end of the work day, wash within the house after applications, store pesticides in their home and apply pesticides near the house and drinking wells. Personal repair of application equipment was significantly more frequent among HPEE cases, as was their first application having taken place more than 10 years previously. Over a working lifetime, at least 1 HPEE was reported by 22% of all commercial applicators in Iowa, 15% of Iowa private applicators and 10% of private applicators in North Carolina. KW - agricultural entomology KW - application KW - exposure KW - health KW - health hazards KW - herbicides KW - nontarget effects KW - occupational hazards KW - pesticides KW - safety at work KW - Iowa KW - North Carolina KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - Appalachian States of USA KW - Southern States of USA KW - South Atlantic States of USA KW - occupational safety KW - United States of America KW - weedicides KW - weedkillers KW - Pesticides and Drugs (General) (HH400) KW - Occupational Health and Safety (VV900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991103614&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates. AU - Strickler, H. D. AU - Kirk, G. D. AU - Figueroa, J. P. AU - Ward, E. AU - Braithwaite, A. R. AU - Escoffery, C. AU - Drummond, J. AU - Goebel, B. AU - Waters, D. AU - McClimens, R. AU - Manns, A. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1999/// VL - 80 IS - 3 SP - 339 EP - 344 SN - 0020-7136 AD - Strickler, H. D.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19992008340. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health; Tropical Diseases N2 - DNA of HPV 16 is found in about half of tumours tested, although population-based studies of human papillomavirus (HPV) DNA have often failed to find high rates of anogenital HPV infection in countries with high cervical cancer rates. To investigate this issue, serology was used to compare HPV 16 exposure in healthy volunteer blood donors in the USA (n=278, enrolled during 1996-97) and similar subjects from a country with 3-fold higher cervical cancer rates, Jamaica (n=257, enrolled during 1987-88). Jamaican sexually transmitted disease (STD) patients (n=831, 1994-95) were also studied to examine in detail the relation of HPV 16 antibodies with sexual history. Serology was conducted using an ELISA employing HPV 16 virus-like particles (VLPs). Age-adjusted seroprevalence rates were greatest among male (29%) and female (42%) STD patients, intermediate in male (19%) and female (24%) Jamaican blood donors and lowest among male (3%) and female (12%) US blood donors. The higher seroprevalence in women was significant, and prevalence tended to increase with age. In multivariate logistic regression, controlling for age and gender, Jamaican blood donors were 4.2-fold (95% CI 2.4-7.2) and STD patients 8.1-fold (95% CI 5.0-13.2) more likely to have HPV 16 VLP antibodies than US blood donors. Among STD patients, HPV 16 antibodies were associated with lifetime number of sex partners and years of sexual activity, as well as other factors. It is suggested that HPV 16 VLP antibodies are strongly associated with sexual behaviour. Moreover, exposure to HPV 16 appears to be much greater in Jamaica than in the USA, consistent with the high rate of cervical cancer in Jamaica. KW - age KW - antibodies KW - cervical cancer KW - disease prevalence KW - human diseases KW - neoplasms KW - risk factors KW - seroprevalence KW - sex KW - sexual behaviour KW - sexually transmitted diseases KW - Jamaica KW - USA KW - human papillomavirus 16 KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Caribbean Community KW - Commonwealth of Nations KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Threshold Countries KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - cancers KW - Human papillomavirus KW - Papovaviridae KW - sexual behavior KW - sexual practices KW - sexuality KW - STDs KW - United States of America KW - venereal diseases KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008340&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A study of adult T-cell leukemia/lymphoma incidence in central Brooklyn. AU - Levine, P. H. AU - Dosik, H. AU - Joseph, E. M. AU - Felton, S. AU - Bertoni, M. A. AU - Cervantes, J. AU - Moulana, V. AU - Miotti, A. B. AU - Goberdhan, L. J. AU - Lee, S. L. AU - Daouad, A. AU - DaCosta, M. AU - Jaffe, E. S. AU - Axiotis, C. A. AU - Cleghorn, F. R. AU - Kahn, A. AU - Welles, S. L. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1999/// VL - 80 IS - 5 SP - 662 EP - 666 SN - 0020-7136 AD - Levine, P. H.: National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992009047. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - A pilot 1-year surveillance programme was established to identify cases of adult T-cell leukaemia/lymphoma (ATL) in 7 of 10 hospitals serving the residents of 18 zip codes of central Brooklyn, New York, USA, with a combined population of 1 184 670. Of the 6198 in-patient beds in the catchment area, approx. 83% were covered. 12 incident cases of ATL were ascertained, all among persons of Afro-Caribbean descent, indicating an annual incidence in African-Americans in this community of approx. 3.2/100 000 person-years. Unexplained hypercalcaemia was the most useful screening method, identifying 3 of 5 patients not referred for possible ATL by a local haematologist. The female:male ratio was 3:1. The age pattern was different from that reported in the Caribbean Basin and closer to the pattern seen in Japan. It is concluded that this study supports evidence that human T-lymphotropic virus (HTLV-I) infection and ATL are endemic in central Brooklyn and it is suggested that a more intensive surveillance programme for this disease coupled with intervention efforts to reduce HTLV-I transmission are warranted. KW - adult T-cell leukaemia KW - disease prevalence KW - epidemiology KW - females KW - HTLV-I infections KW - human diseases KW - hypercalcaemia KW - males KW - surveillance KW - New York KW - USA KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - adult T-cell leukemia KW - HTLV-BLV group KW - hypercalcemia KW - hypercalcinemia KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009047&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA. AU - Groves, F. D. AU - Gridley, G. AU - Wacholder, S. AU - Shu, X. O. AU - Robison, L. L. AU - Neglia, J. P. AU - Linet, M. S. JO - British Journal of Cancer JF - British Journal of Cancer Y1 - 1999/// VL - 81 IS - 1 SP - 175 EP - 178 SN - 0007-0920 AD - Groves, F. D.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-7244, USA. N1 - Accession Number: 19992012028. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health N2 - Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in 9 Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and 439 controls selected by random-digit dialing and individually matched to cases on age, race and telephone exchange. Among matched pairs, similar proportions of cases and controls had received at least 1 dose of oral poliovirus (98%), diphtheria-tetanus-pertussis (97%), and measles-mumps-rubella (90%) vaccines. Only 47% of cases and 53% of controls had received any Haemophilus influenzae type b (Hib) vaccine (relative risk (RR)=0.73; 95% confidence interval (CI) 0.50-1.06). Although similar proportions of cases (12%) and controls (11%) received the polysaccharide Hib vaccine (RR=1.13; 95% CI 0.64-1.98), more controls (41%) than cases (35%) received the conjugate Hib vaccine (RR=0.57; 95% CI 0.36-0.89). Although no relationship was found between most infant vaccinations and subsequent risk of childhood ALL, the findings suggest that infants receiving the conjugate Hib vaccine may be at reduced risk of subsequent childhood acute lymphoblastic leukaemia. Further studies are needed to confirm this association and, if confirmed, to elucidate the underlying mechanism. KW - children KW - diphtheria KW - diphtheria pertussis tetanus vaccines KW - human diseases KW - immunization KW - infants KW - leukaemia KW - measles KW - measles mumps rubella vaccines KW - mumps KW - pertussis KW - risk KW - risk factors KW - rubella KW - tetanus KW - vaccination KW - vaccines KW - USA KW - Bordetella pertussis KW - Clostridium tetani KW - Corynebacterium diphtheriae KW - Haemophilus influenzae KW - Haemophilus influenzae type b KW - man KW - measles virus KW - mumps virus KW - rubella virus KW - Bordetella KW - Alcaligenaceae KW - Burkholderiales KW - Betaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Clostridium KW - Clostridiaceae KW - Clostridiales KW - Clostridia KW - Firmicutes KW - Corynebacterium KW - Corynebacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Haemophilus KW - Pasteurellaceae KW - Pasteurellales KW - Gammaproteobacteria KW - Haemophilus influenzae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Morbillivirus KW - Paramyxovirinae KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Rubulavirus KW - Rubivirus KW - Togaviridae KW - positive-sense ssRNA viruses KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - acute lymphoblastic leukaemia KW - bacterium KW - blood cancer KW - German measles KW - immune sensitization KW - leucaemia KW - leukemia KW - lockjaw KW - United States of America KW - whooping cough KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012028&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland. AU - Chow WongHo AU - Swanson, C. A. AU - Lissowska, J. AU - Groves, F. D. AU - Sobin, L. H. AU - Nasierowska-Guttmejer, A. AU - Radziszewski, J. AU - Regula, J. AU - Hsing, A. W. AU - Shyla Jagannatha AU - Zatonski, W. AU - Blot, W. J. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1999/// VL - 81 IS - 6 SP - 871 EP - 876 SN - 0020-7136 AD - Chow WongHo: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 20001412245. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition N2 - To identify reasons for the high incidence rates of stomach cancer in Poland, we conducted a population-based case-control study in Warsaw. Cases were residents aged 21 to 79 years who were newly diagnosed with stomach cancer between March 1, 1994, and April 30, 1997. Controls were randomly selected from Warsaw residents registered at the nationwide Polish Electronic System of Residence Evidence, frequency-matched to cases by age and sex. Information on demographic characteristics; consumption of cigarettes, alcohol, tea and coffee; diet; medical history; family history of cancer; occupational history; and living conditions during adolescence was elicited by trained interviewers using a structured questionnaire. Included were 464 case (90% of eligible) and 480 controls (87% of eligible). Among men, the risk of stomach cancer was significantly elevated among current smokers (OR=1.7, 95% CI=1.1-2.7) but not among former smokers. The excess risk was largely confined to long-term and heavy smokers, with significant 2-fold excess risk among men who smoked 40 or more pack-years. Among women, an 80% increase in risk was observed in both current and former smokers but dose-response trends were less consistent than among men. Alcohol consumption was not clearly related to risk, and no association was found for drinking regular coffee or herbal tea or using milk/cream in coffee or tea. A significant reduction in risk was linked to daily tea drinking among women, but not among men. Our findings confirm an association with cigarette smoking, which is estimated to account for approximately 20% of stomach cancers diagnosed among Warsaw residents during the study period. KW - adolescents KW - alcohol intake KW - beverages KW - children KW - coffee KW - digestive tract KW - neoplasms KW - questionnaires KW - stomach KW - tea KW - tobacco smoking KW - Poland KW - Camellia sinensis KW - Coffea KW - man KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Rubiaceae KW - Rubiales KW - Gentianales KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Central Europe KW - Europe KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - alcohol consumption KW - cancers KW - drinks KW - gastrointestinal tract KW - teenagers KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412245&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intake of food groups and associated micronutrients in relation to risk of early-stage breast cancer. AU - Potischman, N. AU - Swanson, C. A. AU - Coates, R. J. AU - Gammon, M. D. AU - Brogan, D. R. AU - Curtin, J. AU - Brinton, L. A. JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1999/// VL - 82 IS - 3 SP - 315 EP - 321 SN - 0020-7136 AD - Potischman, N.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 20001412240. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 59-30-3, 68-26-8. Subject Subsets: Human Nutrition N2 - In a large case-control study of early-onset breast cancer, we evaluated risk related to a variety of food groups, associated micronutrients and non-nutritive constituents. Cases treated with chemotherapy appeared to have altered reporting of food intake and were excluded. Analyses were restricted to 568 cases with in situ and localized disease and 1451 population-based controls. Reduced risks were observed for high intake of cereals and grains [odds ratio (OR)=0.84, 95% confidence interval (CI)=0.6-1.1 for highest compared with lowest quartile], vegetables (OR=0.86, 95% CI=0.6-1.1), beans (OR=0.87, 95% CI=0.7-1.2) and fibre from beans (OR=0.88, 95% CI=0.7-1.2). However, no trends of decreasing risk across quartiles of increasing intake were observed. Risk was not associated with dietary constituents related to these food groups including dietary fibre, carotenoids, vitamins A, C and E and folate. Incorporation of information from vitamin supplements did not alter the results for micronutrients. Our data suggest that intakes of cereals and grains, vegetables and beans are associated with minimal, if any, reduction in risk of early-stage breast cancer among young women. KW - beans KW - carotenoids KW - cereals KW - diet studies KW - diets KW - drug therapy KW - fibre KW - folic acid KW - food intake KW - incorporation KW - intake KW - mammary gland neoplasms KW - mammary glands KW - neoplasms KW - nutrients KW - retinol KW - supplements KW - trace elements KW - vegetables KW - vitamin supplements KW - vitamins KW - women KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - axerophthol KW - cancers KW - chemotherapy KW - fiber KW - folacin KW - folate KW - mammary tumour KW - microelements KW - tetraterpenoids KW - United States of America KW - vegetable crops KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412240&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Fusarium mycotoxins in corn and corn products in a high-risk area for gastric cancer in Shandong Province, China. AU - Groves, F. D. AU - Zhang Lian AU - Chang YunSheng AU - Ross, P. F. AU - Casper, H. AU - Norred, W. P. AU - You WeiCheng AU - Fraumeni, J. F., Jr. JO - Journal of AOAC International JF - Journal of AOAC International Y1 - 1999/// VL - 82 IS - 3 SP - 657 EP - 662 SN - 1060-3271 AD - Groves, F. D.: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892-7244, USA. N1 - Accession Number: 19991201982. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 51481-10-8, 17924-92-4. Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology; Maize; Postharvest Research N2 - To determine whether mycotoxins might account for the increased risk of stomach cancer among people consuming fermented pancakes in rural Linqu County in Shandong Province, China, specimens of corn [maize], cornmeal [maize meal], unfermented and fermented pancake batter, and cooked fermented pancakes were collected in 1996 from each of 16 households in Linqu County for analysis by the U.S. Department of Agriculture. Fumonisins B1, B2 and B3 were detected (≥0.5 µg/g) in 19, 25 and 6% of the maize specimens, respectively, as well as in various maize products. No type A trichothecenes were detected; however, the type B trichothecenes deoxynivalenol [vomitoxin] and 15-acetyldeoxynivalenol were detected (≥0.5 µg/g) in 58 and 17% of the maize specimens, respectively, and zearalenone was detected (≥0.5 µg/g) in 15% of the maize meal specimens. The mycotoxins were detected only at low levels (<10 µg/g), which did not increase with fermentation. It is concluded that these findings do not support the hypothesis that mycotoxin contamination increases the risk of gastric cancer among those who consume fermented Chinese pancakes. KW - acetyldeoxynivalenols KW - cereal products KW - contamination KW - foods KW - fumonisins KW - human diseases KW - maize KW - mycotoxins KW - neoplasms KW - risk factors KW - rural areas KW - stomach KW - vomitoxin KW - zearalenone KW - China KW - Fusarium KW - man KW - Zea mays KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Zea KW - Poaceae KW - Cyperales KW - monocotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - corn KW - deoxynivalenol KW - f-2 toxin KW - fungal toxins KW - fungus KW - Hyphomycetes KW - People's Republic of China KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Storage Problems and Pests of Food (QQ111) KW - Food Contamination, Residues and Toxicology (QQ200) KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000) KW - Feed Contamination, Residues and Toxicology (RR200) KW - Crop Produce (QQ050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201982&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evolution of precancerous lesions in a rural chinese population at high risk of gastric cancer. AU - You WeiCheng AU - Li JiYou AU - Blot, W. J. AU - Chang YunSheng AU - Jin MaoLin AU - Gail, M. H. AU - Zhang Lian AU - Liu WeiDong AU - Ma JunLing AU - Hu YuanRen AU - Mark, S. D. AU - Correa, P. AU - Fraumeni, J. F., Jr. AU - Xu GuangWei JO - International Journal of Cancer JF - International Journal of Cancer Y1 - 1999/// VL - 83 IS - 5 SP - 615 EP - 619 SN - 0020-7136 AD - You WeiCheng: National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 20002010706. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Tropical Diseases N2 - The objective was to determine the rates of transition from early to advanced gastric lesions in a population in Linqu County, China, where the gastric cancer (GC) rates are among the highest in the world. An endoscopic screening survey was launched during 1989-90 among 3399 residents aged 34-64 years with precancerous lesions diagnosed from biopsies taken from 7 standard locations in the stomach and from any suspicious sites. The cohort was subsequently followed, with endoscopic and histopathological examinations conducted in 1994. Logistic regression analysis was used to estimate odds ratios (ORs) of progression to advanced lesions of various levels of severity as a function of age, sex and baseline pathology. The rates of progression were higher among older subjects, among men and among subjects with more extensive gastric lesions. 34 incident GCs were identified during the follow-up period. The ORs of GC, adjusted for age and sex, varied from 17.1, for those with baseline diagnoses of superficial intestinal metaplasia (IM), to 29.3, for those with deep IM or mild dysplasia (DYS) or IM with glandular atrophy and neck hyperplasia, to 104.2, for those with moderate or severe DYS, as compared with subjects with superficial gastritis (SG) or chronic atrophic gastritis (CAG) at baseline. It is concluded that the prospective study of a high-risk population revealed sharp increases in the risk of GC and advanced precursor lesions according to the severity of lesions diagnosed at the start of follow-up. KW - atrophic gastritis KW - disease course KW - dysplasia KW - gastritis KW - human diseases KW - hyperplasia KW - lesions KW - neoplasms KW - pathogenesis KW - pathology KW - rural areas KW - stomach cancer KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - disease progression KW - gastric atrophy KW - People's Republic of China KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002010706&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris. AU - Blum, A. AU - Porat, R. AU - Rosenschein, U. AU - Keren, G. AU - Roth, A. AU - Laniado, S. AU - Miller, H. JO - American Journal of Cardiology JF - American Journal of Cardiology Y1 - 1999/// VL - 83 IS - 10 SP - 1488 EP - 1490 SN - 0002-9149 AD - Blum, A.: Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19991410322. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 74-79-3, 10102-43-9. Subject Subsets: Human Nutrition N2 - 10 men with intractable angina pectoris unresponsive to maximum medical therapy and in an end stage condition with no further possible intervention were administered L-arginine for 3 months. There was a significant improvement in clinical condition and and a decrease in cell adhesion molecule and cytokine levels. It is concluded that L-arginine may be therapeutic. KW - amino acids KW - arginine KW - diet KW - heart diseases KW - nitric oxide KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - angina pectoris KW - chest pains KW - coronary diseases KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410322&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Norepinephrine spillover in forearm and subcutaneous adipose tissue before and after eating. AU - Patel, J. N. AU - Eisenhofer, G. AU - Coppack, S. W. AU - Miles, J. M. JO - Journal of Clinical Endocrinology and Metabolism JF - Journal of Clinical Endocrinology and Metabolism Y1 - 1999/// VL - 84 IS - 8 SP - 2815 EP - 2819 SN - 0021-972X AD - Patel, J. N.: National Institute of Neurological Disorders and Stroke, National institutes of Health, 10 Centre Drive, MSC-1424, Building 10, Room 6N252, Bethesda, Maryland 20892-1424, USA. N1 - Accession Number: 19991415402. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 51-43-4, 9004-10-8, 51-40-1, 51-41-2, 69815-49-2. Subject Subsets: Human Nutrition N2 - The effect of feeding on systemic and local sympathetic nervous system activity and lipolysis was studied in lean healthy subjects (3 women and 5 men; aged 27.0±2.0 years; body mass index, 23.4±1.2) using isotope dilution methodology and arterio-venous sampling. Feeding increased arterial norepinephrine (NE) concentration (mean premeal, 0.96±0.12 nmol/litre; mean postmeal, 1.28±0.14 nmol/litre; P<0.02) and total body NE spillover (mean premeal, 2.11±0.30 nmol/min per litre; mean postmeal, 2.76±0.31 nmol/min per litre; P<0.02), whereas the arterial epinephrine concentration decreased (mean premeal, 289±61 pmol/litre; mean postmeal, 170±5 pmol/litre; P<0.02). Palmitate concentration and total body systemic rate of appearance of palmitate declined postprandially (mean premeal, 117±15 µmol/min; mean postmeal, 38±4 µmol/min; P<0.01). NE spillover increased by the same proportion in both forearm and adipose tissue. It is concluded that a meal caused differential changes in systemic sympatho-adrenal activity and an increase in sympathetic activity in adipose tissue postprandially. However, this increase in postprandial sympathetic activity was not enough to overcome the inhibition of lipolysis by insulin. KW - adipose tissue KW - anthropometric dimensions KW - epinephrine KW - feeding KW - food intake KW - insulin KW - lipolysis KW - nervous system KW - norepinephrine KW - sympathetic nervous system KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - adrenaline KW - anthropometric measurements KW - noradrenaline KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415402&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE. AU - Corti, M. C. AU - Guralnik, J. M. AU - Ferrucci, L. AU - Izmirlian, G. AU - Leveille, S. G. AU - Pahor, M. AU - Cohen, H. J. AU - Pieper, C. AU - Havlik, R. J. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1999/// VL - 89 IS - 3 SP - 308 EP - 314 SN - 0090-0036 AD - Corti, M. C.: Epidemiology, Demography, and Biometry Program, National Institute on Aging, NIH, 7201 Wisconsin Ave, Room 3C-309, Bethesda, MD 20892-9205, USA. N1 - Accession Number: 19992006416. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina, USA were interviewed in 1986 and followed up for mortality until 1994. Hazard ratios (HRs) for all-cause and cause-specific mortality were calculated, with adjustment for sociodemographic and coronary heart disease (CHD) risk factors. Black persons had higher mortality rates than Whites at young-old age (65-80 years) but had significantly lower mortality rates after age 80. Black persons age 80 or older had a significantly lower risk of all-cause mortality (HR of Blacks vs Whites, 0.75; 95% confidence interval [CI]=0.62, 0.90) and of CHD mortality (HR 0.44; 95% CI=0.30, 0.66). These differences were not observed for other causes of death. Racial differences in mortality are modified by age. This mortality crossover could be attributed to selective survival of the healthiest oldest Blacks or to other biomedical factors affecting longevity after age 80. Because the crossover was observed for CHD deaths only, age overreporting by Black older persons seems an unlikely explanation of the mortality differences. KW - blacks KW - cardiovascular diseases KW - ethnic groups KW - heart diseases KW - human diseases KW - mortality KW - races KW - whites KW - North Carolina KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Appalachian States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - South Atlantic States of USA KW - coronary diseases KW - death rate KW - racial differences KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006416&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Residential radon exposure and risk of lung cancer in Missouri. AU - Alavanja, M. C. R. AU - Lubin, J. H. AU - Mahaffey, J. A. AU - Brownson, R. C. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1999/// VL - 89 IS - 7 SP - 1042 EP - 1048 SN - 0090-0036 AD - Alavanja, M. C. R.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 8000, Mail Stop 8000, Bethesda, MD 20892, USA. N1 - Accession Number: 20002005795. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 10043-92-2. N2 - This study investigated residential radon exposure and lung cancer risk, using both standard radon dosimetry and a new radon monitoring technology that, evidence suggests, is a better measure of cumulative radon exposure. Missouri women (aged 30 to 84 years) newly diagnosed with primary lung cancer during 1 January 1993-31 January 1994 were invited to participate in this population-based case-control study. Both indoor air radon detectors and CR-39 alpha-particle detectors (surface monitors) were used. When surface monitors were used, a significant trend in lung cancer odds ratios was observed for 20-year time-weighted-average radon concentrations. When surface monitors were used, but not when standard radon dosimetry was used, a significant lung cancer risk was found for radon concentrations at and above the action level for mitigation of houses currently used in the USA (148 Bqm-3). The risk was below the action level used in Canada (750 Bqm-3) and many European countries (200-400 Bqm-3). KW - dwellings KW - human diseases KW - lung cancer KW - neoplasms KW - radon KW - risk factors KW - women KW - Missouri KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancers KW - United States of America KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Pollution and Degradation (PP600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005795&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Adolescent reproductive events and subsequent breast cancer risk. AU - Marcus, P. M. AU - Baird, D. D. AU - Millikan, R. C. AU - Moorman, P. G. AU - Qaqish, B. AU - Newman, B. JO - American Journal of Public Health JF - American Journal of Public Health Y1 - 1999/// VL - 89 IS - 8 SP - 1244 EP - 1247 SN - 0090-0036 AD - Marcus, P. M.: Biometry Branch Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19990404668. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - This study investigated the relationship between reproductive events during adolescence and subsequent breast cancer risk. Logistic regression models used self-reported data from 862 case patients and 790 controls in the Carolina Breast Cancer Study. Miscarriage, induced abortion, and full-term pregnancy before 20 years of age were not associated with breast cancer. Among pre-menopausal women, breast-feeding before 20 years of age was inversely associated with disease. Oral contraceptive use before 18 years of age was positively associated with disease risk among African American women only. Pregnancy during adolescence does not appear to influence breast cancer risk, but breast-feeding may. A possible increased breast cancer risk among African American women who used oral contraceptives as adolescents warrants further study. KW - adolescents KW - breast feeding KW - children KW - ethnic groups KW - induced abortion KW - infants KW - mammary gland neoplasms KW - models KW - oral contraceptives KW - pregnancy KW - risk factors KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - gestation KW - mammary tumour KW - teenagers KW - United States of America KW - Milk and Dairy Produce (QQ010) KW - Physiology of Human Nutrition (VV120) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990404668&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. AU - Stolzenberg-Solomon, R. Z. AU - Albanes, D. AU - Nieto, F. J. AU - Hartman, T. J. AU - Tangrea, J. A. AU - Rautalahti, M. AU - Sehlub, J. AU - Virtamo, J. AU - Taylor, P. R. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1999/// VL - 91 IS - 6 SP - 535 EP - 541 SN - 0027-8874 AD - Stolzenberg-Solomon, R. Z.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19991404935. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 59-30-3, 65-23-6. Subject Subsets: Human Nutrition N2 - A nested case-control study within the α-Tocopherol, β-Carotene Cancer Prevention Study cohort of 29 133 male Finnish smokers aged 50-69 years was conducted. 126 subjects with incident exocrine pancreatic cancer were matched by date of baseline blood draw (±30 days), study centre, age (±5 years), trial intervention group, and completion of dietary history to 247 control subjects, who were alive and free from cancer at the time the case subjects were diagnosed. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined by use of conditional logistic regression. Reported P values are two-tailed. Serum folate and pyridoxal-5′-phosphate (PLP) concentrations showed significant inverse dose-response relationships with pancreatic cancer risk, with the highest serum tertiles having approximately half the risk of the lowest (folate: OR=0.45; 95% CI=0.24-0.82; P for trend=0.009, and PLP: OR=0.48; 95% CI=0.26-0.88; P for trend=0.02). An increased pancreatic cancer risk was also observed with greater exposure to cigarettes (pack-years (number of packs smoked per day×number of years of smoking), highest versus lowest quartile: OR=2.13; 95% CI=1.13-3.99; P for trend=0.04). It is concluded that maintaining adequate folate and pyridoxine status may reduce the risk of pancreatic cancer and confirm the risk previously associated with cigarette smoking. KW - blood chemistry KW - diet KW - dietary history KW - folic acid KW - neoplasms KW - pancreas KW - pyridoxine KW - tobacco smoking KW - Finland KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - OECD Countries KW - Scandinavia KW - Northern Europe KW - Europe KW - cancers KW - folacin KW - folate KW - food history KW - Human Physiology and Biochemistry (VV050) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404935&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions. AU - Liaw KaiLi AU - Glass, A. G. AU - Manos, M. M. AU - Greer, C. E. AU - Scott, D. R. AU - Sherman, M. AU - Burk, R. D. AU - Kurman, R. J. AU - Wacholder, S. AU - Rush, B. B. AU - Cadell, D. M. AU - Lawler, P. AU - Tabor, D. AU - Schiffman, M. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1999/// VL - 91 IS - 11 SP - 954 EP - 960 SN - 0027-8874 AD - Liaw KaiLi: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA. N1 - Accession Number: 19992009700. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health N2 - To clarify the role of human papillomavirus (HPV) in the aetiology of squamous intra-epithelial lesions (SIL), the risk of SIL was investigated prospectively following polymerase chain reaction (PCR)-based DNA testing for a wide range of genital HPV types in a cohort of initially cytologically normal women. Starting in April 1989, 17 654 women who were receiving routine cytological screening at Kaiser Permanente (Portland, OR, USA) were followed for the development of SIL. During follow-up, 380 incident case patients and 1037 matched control subjects were eligible for this nested case-control study. Cervical lavages collected at enrollment and, later, at the time of case diagnosis (or the corresponding time for selection of control subjects) were tested for HPV DNA using a PCR-based method. The data were analysed as contingency tables with 2-sided P values or, for multivariable analyses, using odds ratios (ORs) with 95% confidence intervals (CIs). In comparison with initially HPV-negative women, women who tested positive for HPV DNA at enrollment were 3.8 times (95% CI=2.6-5.5) more likely to have low-grade SIL subsequently diagnosed for the first time during follow-up and 12.7 times more likely (95% CI=6.2-25.9) to develop high-grade SIL. At the time of diagnosis, the cross-sectional association of HPV DNA and SIL was extremely strong (OR=44.4 and 95% CI=24.2-81.5 for low-grade SIL and OR=67.1 and 95% CI=19.3-233.7 for high-grade SIL). HPV16 was the virus type most predictive of SIL, even low-grade SIL. These findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia. KW - aetiology KW - carcinoma KW - cervical cancer KW - cervix KW - epithelium KW - human diseases KW - lesions KW - neoplasms KW - women KW - Oregon KW - USA KW - human papillomaviruses KW - man KW - Papillomavirus KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pacific Northwest States of USA KW - Pacific States of USA KW - Western States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Papillomaviridae KW - cancers KW - causal agents KW - etiology KW - human papillomavirus KW - Papovaviridae KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009700&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Changing geographic patterns of lung cancer mortality in the United States, 1950 through 1994. AU - Devesa, S. S. AU - Grauman, D. J. AU - Blot, W. J. AU - Fraumeni, J. F., Jr. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1999/// VL - 91 IS - 12 SP - 1040 EP - 1050 SN - 0027-8874 AD - Devesa, S. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992011316. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - Age-adjusted race- and sex-specific lung cancer mortality rates for 1950-94 were calculated for 9 Census Divisions and 508 State Economic Areas of the USA. Pronounced geographical variation in lung cancer rates was evident, with the patterns changing substantially over time. Among white males in the 1950s and 1960s, high rates were observed in urban areas of the northeast and north central states and in areas along the southeast and Gulf coasts. By the 1970s, the northern excess began to fade, with high rates starting to cover wider areas of the south. By the 1980s to the mid-1990s, clustering of elevated rates was prominent across the southeast and south central areas, with relatively low rates throughout much of the northeast. Among white females, little geographical variation was evident in the 1950s, but thereafter relatively high rates began to appear in clusters along the Atlantic and Pacific coasts. For both sexes, consistently low rates were seen in the mountain and the plains states. Rates among blacks were consistently elevated in northern areas and low across the south. It is concluded that the changing mortality patterns for lung cancer generally coincide with regional trends in cigarette smoking, indicating that public health measures aimed at smoking prevention and cessation should have a dramatic effect in reducing lung cancer rates. KW - epidemiology KW - ethnic groups KW - human diseases KW - lung cancer KW - lungs KW - mortality KW - neoplasms KW - surveillance KW - tobacco smoking KW - urban areas KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - death rate KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011316&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent trends in childhood cancer incidence and mortality in the United States. AU - Linet, M. S. AU - Ries, L. A. G. AU - Smith, M. A. AU - Tarone, R. E. AU - Devesa, S. S. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1999/// VL - 91 IS - 12 SP - 1051 EP - 1058 SN - 0027-8874 AD - Linet, M. S.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992011317. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - Cancers diagnosed in 14 540 children aged <15 years during 1975-95 and reported to 9 population-based registries in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program were investigated. Age-adjusted incidence was analysed according to anatomical site and histological categories of the International Classification of Childhood Cancer. Age-adjusted US mortality rates were calculated. Trends in rates were evaluated by use of standard regression methods. A modest rise in the incidence of leukaemia, the most common childhood cancer, was largely due to an abrupt increase from 1983 to 1984; rates have decreased slightly since 1989. For brain and other central nervous system (CNS) cancers, incidence rose modestly, although statistically significantly (two-sided P=0.020), largely from 1983 to 1986. A few rare childhood cancers demonstrated upward trends (the 40% of skin cancers designated as dermatofibrosarcomas, adrenal neuroblastomas and retinoblastomas, the latter 2 in infants only). In contrast, incidence decreased modestly but statistically significantly for Hodgkin's disease (two-sided P=0.037). Mortality rates declined steadily for all major childhood cancer categories, although less rapidly for brain/CNS cancers. It is concluded that there was no substantial change in incidence for the major paediatric cancers, and rates remained relatively stable since the mid-1980s. The modest increases that were observed for brain/CNS cancers, leukaemia, and infant neuroblastoma were confined to the mid-1980s. The patterns indicated that the increases likely reflected diagnostic improvements or reporting changes. Dramatic declines in childhood cancer mortality represent treatment-related improvements in survival. KW - central nervous system KW - children KW - disease prevalence KW - epidemiology KW - Hodgkin's disease KW - human diseases KW - incidence KW - infants KW - leukaemia KW - mortality KW - neoplasms KW - skin KW - skin cancer KW - surveillance KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - blood cancer KW - cancer of the lymph nodes KW - cancers KW - CNS KW - death rate KW - dermis KW - leucaemia KW - leukemia KW - lymphogranuloma KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011317&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Brain and other central nervous system cancers: recent trends in incidence and mortality. AU - Legler, J. M. AU - Ries, L. A. G. AU - Smith, M. A. AU - Warren, J. L. AU - Heineman, E. F. AU - Kaplan, R. S. AU - Linet, M. S. JO - Journal of the National Cancer Institute JF - Journal of the National Cancer Institute Y1 - 1999/// VL - 91 IS - 16 SP - 1382 EP - 1390 SN - 0027-8874 AD - Legler, J. M.: Cancer Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19992012086. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Public Health N2 - During the 1980s, the incidence of primary malignant brain and other central nervous system tumours (brain cancer) was reported to be increasing among all age groups in the USA, while mortality was declining for persons <65 years of age. Data was analysed to provide updates on incidence and mortality trends for brain cancer in the USA and to examine these patterns to determine their causes. Data on incidence of brain cancer, overall and according to histology and anatomic site, and on relative survival were obtained from the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute for 1975-95. Mortality data were obtained from the National Center for Health Statistics. Medicare procedure claims from the National Cancer Institute's SEER-Medicare database were used for imaging trends. Statistically significant changes in incidence trends were identified, and annual percent changes were computed for log linear models. Rates stabilized for all age groups during the most recent period for which SEER data were available, except for the group containing individuals ≥85 years of age. Mortality trends continued to decline for the younger age groups, and the steep increases in mortality seen in the past for the elderly slowed substantially. Patterns differed by age group according to the site and grade of tumours between younger and older patients. During the last decade, use of computed tomography scans was relatively stable for those 65-74 years of age, but increased among those ≥85 years of age. It is suggested that improvements in diagnosis and changes in the diagnosis and treatment of elderly patients provide likely explanations for the observed patterns in brain cancer trends. KW - age KW - age groups KW - brain KW - brain diseases KW - central nervous system KW - computed tomography KW - disease prevalence KW - elderly KW - epidemiology KW - human diseases KW - incidence KW - mortality KW - neoplasms KW - nervous system diseases KW - statistics KW - survival KW - trends KW - tumours KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - aged KW - brain disorders KW - cancers KW - cerebrum KW - CNS KW - death rate KW - elderly people KW - neuropathy KW - older adults KW - senior citizens KW - tumors KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012086&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium falciparum: invasion of Aotus monkey red blood cells and adaptation to Aotus monkeys. AU - Kaneko, O. AU - Soubes, S. C. AU - Miller, L. H. JO - Experimental Parasitology JF - Experimental Parasitology Y1 - 1999/// VL - 93 IS - 2 SP - 116 EP - 119 SN - 0014-4894 AD - Kaneko, O.: Malaria Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room B1-37, 4 Center Drive, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000803661. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology N2 - The in vitro infection of Aotus and human erythrocytes by multiple clones and lines of Plasmodium falciparum revealed 3 patterns of cell invasion. Group 1 clones/lines invaded Aotus cells at a rate usually >40% of the rate of invasion of human control cells. Three of these (Malayan Camp, Camp/A1 and FVO) were previously adapted to Aotus and the other group 1 parasites are thought to be Aotus-adapted FVO that had contaminated and overgrown other lines. Group 2 parasites contained clones with an invasion rate 3.5-19.2% that of human control cells and had never been in Aotus before. Group 3 consisted of a single clone (3D7) that was resistant to invasion of Aotus cells (invasion rate 0-1.2% that of human control cells). KW - adaptation KW - cell invasion KW - cell lines KW - clones KW - erythrocytes KW - experimental infection KW - host parasite relationships KW - in vitro KW - infectivity KW - laboratory animals KW - parasites KW - strain differences KW - strains KW - Aotus KW - Plasmodium falciparum KW - Primates KW - protozoa KW - Cebidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - blood red cells KW - experimental transmission KW - parasite host relationships KW - red blood cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000803661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals. AU - Rabkin, C. S. AU - Yang QuanEn AU - Goedert, J. J. AU - Nguyen, G. AU - Mitsuya, H. AU - Sei, S. JO - Blood JF - Blood Y1 - 1999/// VL - 93 IS - 6 SP - 1838 EP - 1842 SN - 0006-4971 AD - Rabkin, C. S.: Viral Epidemiology Branch, HIV and AIDS Malignancy Branch, and Experimental Retrovirology Section, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992007144. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health N2 - A group of 746 HIV-1-infected persons from the USA was examined for associations of stromal cell-derived factor 1 (SDF-1) chemokine and CCR5 and CCR2 chemokine receptor gene variants with the risk of B-cell non-Hodgkin's lymphoma (NHL). The SDF1-3′A chemokine variant, which is carried by 37% of whites and 11% of blacks, was associated with approximate doubling of the NHL risk in heterozygotes and roughly a 4-fold increase in homozygotes. After a median follow-up of 11.7 years, NHL developed in 6 (19%) of 30 SDF1-3′A/3′A homozygotes and 22 (10%) of 202 SDF1-+/3′A heterozygotes, compared with 24 (5%) of 514 wild-type subjects. The acquired immunodeficiency syndrome (AIDS)-protective chemokine receptor variant CCR5-Δ32 was highly protective against NHL, whereas the AIDS-protective variant CCR2-64l had no significant effect. Racial differences in SDF1-3′A frequency may contribute to the lower risk of HIV-1-associated NHL in blacks compared with whites. SDF-1 genotyping of HIV-1-infected patients may identify subgroups warranting enhanced monitoring and targeted interventions to reduce the risk of NHL. KW - chemokines KW - genetics KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - lymphoma KW - mutations KW - receptors KW - risk KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007144&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Detection of human herpesvirus-8 and Epstein-Barr virus DNA in primary intraocular lymphomas. AU - Chan ChiChao AU - Shen DeFen AU - Whitcup, S. M. AU - Nussenblatt, R. B. AU - Phuc LeHoang AU - Roberge, F. G. AU - Cassoux, N. AU - Herbort, C. AU - Zhuang, Z. P. T2 - Blood JO - Blood JF - Blood Y1 - 1999/// VL - 93 IS - 8 SP - 2749 EP - 2751 SN - 0006-4971 AD - Chan ChiChao: National Eye Institute, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992010248. Publication Type: Correspondence. Language: English. Number of References: 10 ref. Registry Number: 9007-49-2. KW - DNA KW - eyes KW - human diseases KW - human herpesviruses KW - lymphoma KW - pathogenesis KW - USA KW - Human herpesvirus 4 KW - human herpesvirus 8 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - viruses KW - Rhadinovirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - deoxyribonucleic acid KW - Epstein-Barr virus KW - human herpesvirus KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010248&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4+ T cells and decreases their susceptibility to apoptosis in vitro and in vivo. AU - Sloand, E. M. AU - Kumar, P. N. AU - Kim, S. AU - Aniruddho Chaudhuri AU - Weichold, F. F. AU - Young, N. S. JO - Blood JF - Blood Y1 - 1999/// VL - 94 IS - 3 SP - 1021 EP - 1027 SN - 0006-4971 AD - Sloand, E. M.: National Institutes of Health, National Heart, Lung and Blood Institute, 31 Center Dr. MSC 2490, Building 31, Room 4A11, Bethesda, MD, 20892-2490, USA. N1 - Accession Number: 20002006881. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 155213-67-5. N2 - The effect of protease inhibitors on Fas-Receptor (CD95)(Fas-R (CD95)), interleukin converting enzyme (ICE (caspase 1)) expression, apoptosis, and cell death in CD4+ T cells of (1) human immunodeficiency virus (HIV)-infected patients who were receiving protease inhibitors, and (2) normal and patient CD4+ T cells cultured with a protease inhibitor in vitro was investigated. 15 American patients with advanced HIV disease on treatment showed dramatically decreased CD4+ T-cell ICE expression, diminished apoptosis, and increased numbers of CD4+ cells within 6 weeks of institution of protease inhibitor therapy, and before down-modulation of Fas-R (CD95) expression was evident. To determine the role of HIV infection, the effect of ritonavir, a protease inhibitor, on normal and patient cells in vitro was investigated. Stimulated and unstimulated normal CD4+ T cells, cultured with protease inhibitor, demonstrated markedly decreased apoptosis and ICE expression (P=0.01). While Fas-R expression was not significantly altered during short-term culture by such treatment, Fas-Ligand (Fas-L) membrane expression of phytohaemagglutinin (PHA)-stimulated blood lymphocytes was decreased by protease inhibitor. In the presence of ritonavir, CD4+ T cells from HIV-infected patients showed similar changes in ICE intracellular levels without alteration of Fas expression. In conclusion, protease inhibitors appeared to decrease CD4+ T-cell ICE expression and apoptosis before they affected Fas-R expression in HIV-infected patients. This action was independent of HIV infection, as similar effects were seen in CD4+ T cells from normal controls. Some of the benefit of protease inhibitors may be related to modification of programmed cell death, which increases CD4+ T-cell number. KW - apoptosis KW - CD4 antigens KW - gene expression KW - human diseases KW - human immunodeficiency viruses KW - infections KW - interleukins KW - phytohaemagglutinins KW - proteinase inhibitors KW - ritonavir KW - T lymphocytes KW - Maryland KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - CD4 KW - human immunodeficiency virus KW - phytohemagglutinins KW - protease inhibitors KW - T cells KW - United States of America KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006881&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV and HCV infection among drug users in Japan. AU - Wada, K. AU - Greberman, S. B. AU - Konuma, K. AU - Hirai, S. JO - Addiction JF - Addiction Y1 - 1999/// VL - 94 IS - 7 SP - 1063 EP - 1069, 1093, 1099 SN - 0965-2140 AD - Wada, K.: National Center of Neurology and Psychiatry, National Institute of Mental Health, Division of Drug Dependence and Psychotropic Drug Clinical Research, 1-7-3 Kohnodai, Ichikawa-shi, Chiba 272-0827, Japan. N1 - Accession Number: 19992011527. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 16 ref. N2 - The seroprevalence of human immunodeficiency virus (HIV), hepatitis C virus, injecting drug use, unsafe sexual behaviours, self-mutilation and tattoos was assessed in patients attending a drug and alcohol treatment centre in Japan. A cross-sectional survey was carried out at the National Sanitarium of Shimousa, Chiba, Japan, a 32-bed inpatient centre specializing in drug and alcohol treatment. HIV antibody, hepatitis C antibody, hepatitis B antigen and antibody levels were measured; questionnaires for history of sexual activities, needle and syringe use analysed; physical examination with assessment of self-amputated finger joints, tattoos, scars from lacerations and cigarette burns noted. No patients tested positive for anti-HIV. The seroprevalence of anti-HCV positives was 53.8% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. Past needle sharing was reported by 82.1% of methamphetamine-dependent patients, 18.4% of solvent-dependent patients and 5.6% of alcohol-dependent patients. A history of syringe sharing was reported by 87.2% of methamphetamine-dependent patients. More than two-thirds of all patients reported contact with commercial sex workers. Casual sexual contacts were more common among solvent and methamphetamine-dependent patients than those dependent on alcohol. Tattoos and cigarette burns were more common among methamphetamine and solvent-dependent patients than among alcohol-dependent patients. Among the methamphetamine-dependent patients, 20.5% reported self-amputated finger joints compared with none in the other patient groups. HCV prevalence is a significant problem among methamphetamine users in Japan, probably because of a high rate of needle and/or syringe sharing. Although HIV infection is currently negligible, the very high rate of needle and syringe sharing could give rise to a significant increase in the HIV rate among drug users in the future. KW - amphetamines KW - contamination KW - disease prevalence KW - disease transmission KW - drug users KW - human diseases KW - human immunodeficiency viruses KW - infection KW - injecting drug users KW - injection KW - sexual behaviour KW - surveys KW - trauma KW - viral diseases KW - Japan KW - hepatitis C virus KW - man KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - drug abusers KW - human immunodeficiency virus KW - i.v. drug abusers KW - i.v. drug users KW - intravenous drug users KW - methamphetamines KW - self mutilation KW - sexual behavior KW - sexual practices KW - sexuality KW - traumas KW - viral infections KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011527&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients. AU - Kaufman, S. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1999/// VL - 96 IS - 6 SP - 3160 EP - 3164 SN - 0027-8424 AD - Kaufman, S.: Laboratory of Neurochemistry, National Institute of Mental Health, 36 Convent Drive, MSC 4096, Building 36, Room 3D30, Bethesda, MD 20892, USA. N1 - Accession Number: 19991407014. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 63-91-2. Subject Subsets: Human Nutrition N2 - The derivation of a quantitative model of phenylalanine metabolism in humans is described. The model is based on the kinetic properties of pure recombinant human phenylalanine hydroxylase and on estimates of the in vivo rates of phenylalanine transamination and protein degradation. Calculated values for the steady-state concentration of blood phenylalanine, rate of clearance of phenylalanine from the blood after an oral load of the amino acid, and dietary tolerance of phenylalanine all agree well with data from normal as well as from phenylketonuric patients and obligate heterozygotes. These calculated values may help in the decision about the degree of restriction of phenylalanine intake that is necessary to achieve a satisfactory clinical outcome in classical patients and in those with milder forms of the disease. KW - amino acids KW - analytical methods KW - blood KW - diet KW - hyperphenylalaninaemia KW - intake KW - kinetics KW - metabolism KW - models KW - phenylalanine KW - phenylketonuria KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - hyperphenylalaninemia KW - Phenylalanine hydroxylase deficiency KW - Techniques and Methodology (ZZ900) KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407014&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. AU - Tataranni, P. A. AU - Gautier, J. F. AU - Chen KeWei AU - Uecker, A. AU - Bandy, D. AU - Salbe, A. D. AU - Pratley, R. E. AU - Lawson, M. AU - Reiman, E. M. AU - Ravussin, E. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1999/// VL - 96 IS - 8 SP - 4569 EP - 4574 SN - 0027-8424 AD - Tataranni, P. A.: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases-National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA. N1 - Accession Number: 19991407756. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition N2 - Regional cerebral blood flow (rCBF), a marker of neuronal activity, was measured in 11 healthy, normal-weight men by using positron emission tomography in a state of hunger (after 36-h fast) and a state of satiation (after a liquid meal). Hunger was associated with significantly increased rCBF in the vicinity of the hypothalamus and insular cortex and in additional paralimbic and limbic areas (orbitofrontal cortex, anterior cingulate cortex, and parahippocampal and hippocampal formation), thalamus, caudate, precuneus, putamen, and cerebellum. Satiation was associated with increased rCBF in the vicinity of the ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and inferior parietal lobule. Changes in plasma insulin concentrations in response to the meal were negatively correlated with changes in rCBF in the insular and orbitofrontal cortex. Changes in plasma free fatty acid concentrations in response to the meal were negatively correlated with changes in rCBF in the anterior cingulate and positively correlated with changes in rCBF in the dorsolateral prefrontal cortex. In conclusion, these findings raise the possibility that several regions of the brain participate in the regulation of hunger and satiation and that insulin and free fatty acids may be metabolic modulators of postprandial brain neuronal events. Although exploratory, the present study provides a foundation for investigating the human brain regions and cognitive operations that respond to nutritional stimuli. KW - appetite KW - blood flow KW - brain KW - cerebellum KW - fatty acids KW - hunger KW - hypothalamus KW - insulin KW - men KW - nervous system KW - satiety KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - brain cerebellum KW - cerebrum KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407756&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms. AU - Walker, P. S. AU - Scharton-Kersten, T. AU - Krieg, A. M. AU - Love-Homan, L. AU - Rowton, E. D. AU - Udey, M. C. AU - Vogel, J. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1999/// VL - 96 IS - 12 SP - 6970 EP - 6975 SN - 0027-8424 AD - Walker, P. S.: Dermatology Branch, National Cancer Institute, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1908, USA. N1 - Accession Number: 19990805942. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9007-49-2, 9008-11-1. Subject Subsets: Protozoology N2 - Resistance to murine leishmaniasis correlates with development of a CD4+ T helper 1 (Th1)-predominant immune response. To determine whether immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODN), known to promote a Th1 immune response, could provide protection from Leishmania infection, CpG-ODN and freeze-thawed (F/T) L. major were coinjected intradermally into susceptible BALB/c mice. A Leishmania-specific Th1-predominant immune response was induced; 40% of animals were protected from subsequent challenge, with 0% protection of animals injected with F/T Leishmania organisms and PBS, F/T organisms and control ODN, or F/T organisms alone. More striking protection (65-95%) was seen in mice first infected with intact Leishmania and then injected with CpG-ODN, either at the site of infection or at a remote site. To determine whether the protection provided by CpG-ODN depended on interleukin (IL)-12 and interferon (IFN)-γ production, both IFN-γ-deficient mice and mice treated with neutralizing anti-IL-12 monoclonal antibody were first inoculated with Leishmania and then treated with either CpG-ODN, ODN or PBS. None of these IFN-γ-deficient mice survived (0, 0 and 0 of 20, respectively) and neutralization of IL-12 completely abolished the therapeutic protection provided by CpG-ODN (0 of 20 mice surviving). It was concluded that immunostimulatory DNA sequences probably exert systemic effects via IL-12 and IFN-γ-dependent mechanisms and hold considerable promise as both vaccine adjuvants and potential therapeutic agents. KW - CD4+ lymphocytes KW - disease resistance KW - DNA KW - experimental infections KW - immune response KW - immunostimulation KW - interferon KW - interleukin 12 KW - laboratory animals KW - leishmaniasis KW - nucleotide sequences KW - parasites KW - T lymphocytes KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - CD4+ cells KW - deoxyribonucleic acid KW - DNA sequences KW - immunity reactions KW - immunological reactions KW - leishmaniosis KW - oligodeoxynucleotides KW - resistance to disease KW - T cells KW - T4 lymphocytes KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805942&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. AU - Davey, R. T., Jr. AU - Niranjan Bhat AU - Yoder, C. AU - Chun TaeWook AU - Metcalf, J. A. AU - Robin Dewar AU - Ven Natarajan AU - Lempicki, R. A. AU - Adelsberger, J. W. AU - Miller, K. D. AU - Kovacs, J. A. AU - Polis, M. A. AU - Walker, R. E. AU - Falloon, J. AU - Masur, H. AU - Gee, D. AU - Baseler, M. AU - Dimitrov, D. S. AU - Fauci, A. S. AU - Lane, H. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1999/// VL - 96 IS - 26 SP - 15109 EP - 15114 SN - 0027-8424 AD - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, (NIAID), Bethesda, MD 20892, USA. N1 - Accession Number: 20002009545. Publication Type: Journal Article. Language: English. Number of References: 31 ref. N2 - Identifying the immunological and virological consequences of discontinuing antiretroviral therapy in HIV-infected patients is of major importance in developing long-term treatment strategies for patients with HIV-1 infection. A trial was conducted to characterize these parameters after interruption of highly active antiretroviral therapy (HAART) in patients who had maintained prolonged viral suppression on antiretroviral drugs. 18 patients with CD4+ T cell counts ≥350 cells/µl and viral load below the limits of detection for ≥1 year while on HAART were enrolled prospectively in a trial [in the USA] in which HAART was discontinued. 12 of these patients had received prior IL-2 therapy and had low frequencies of resting, latently infected CD4 cells. Viral load relapse to >50 copies/ml occurred in all 18 patients independent of prior IL-2 treatment, beginning most commonly during weeks 2-3 after cessation of HAART. The mean relapse rate constant was 0.45 (0.20 log10 copies) day-1, which was very similar to the mean viral clearance rate constant after drug resumption of 0.35 (0.15 log10 copies) day-1 (P=0.28). One patient experienced a relapse delay to week 7. All patients except one experienced a relapse burden to >5000 RNA copies/ml. Ex vivo labelling with BrdUrd showed that CD4 and CD8 cell turnover increased after withdrawal of HAART and correlated with viral load whereas lymphocyte turnover decreased after reinitiation of drug treatment. It is concluded that virological relapse occurs rapidly in patients who discontinue suppressive drug therapy, even in patients with a markedly diminished pool of resting, latently infected CD4+ T cells. KW - antiviral agents KW - CD4+ lymphocytes KW - drug therapy KW - highly active antiretroviral therapy KW - HIV-1 infections KW - human diseases KW - immunology KW - relapse KW - T lymphocytes KW - viral load KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - CD4+ cells KW - chemotherapy KW - HAART KW - human immunodeficiency virus type 1 KW - recurrence of disease KW - relapses KW - T cells KW - T4 lymphocytes KW - United States of America KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009545&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis. AU - Charlab, R. AU - Valenzuela, J. G. AU - Rowton, E. D. AU - Ribeiro, J. M. C. JO - Proceedings of the National Academy of Sciences of the United States of America JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 1999/// VL - 96 IS - 26 SP - 15155 EP - 15160 SN - 0027-8424 AD - Charlab, R.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, MSC 0425, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000505113. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 37288-34-9, 9033-33-4. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology N2 - Subtractive cloning combined with biochemical approaches was used to discover activities in the salivary glands of L. longipalpis. Sequences of 9 full-length cDNA clones were obtained, 5 of which were possibly associated with blood-meal acquisition, each having cDNA similarity to: (i) Cimex lectularius apyrase, (ii) a 5′-nucleotidase/phosphodiesterase, (iii) a hyaluronidase, (iv) a protein containing a carbohydrate-recognition domain (CRD), and (v) a RGD-containing peptide with no significant matches to known proteins in the BLAST databases. Following these findings, the salivary apyrase activity of L. longipalpis was observed to be similar to that of Cimex apyrase in its metal requirements. The predicted isoelectric point of the putative apyrase matched the value found for Lutzomyia salivary apyrase. A 5′-nucleotidase, as well as hyaluronidase activity, was found in the salivary glands, and the CRD-containing cDNA matches the N-terminal sequence of the HPLC-purified salivary anticlotting protein. A cDNA similar to α-amylase was discovered and salivary enzymatic activity demonstrated for the first time in a bloodsucking arthropod. Full-length clones were also found coding for 3 proteins of unknown function matching, respectively, the N-terminal sequence of an abundant salivary protein, having similarity to the CAP superfamily of proteins and the Drosophila yellow protein. Finally, 2 partial sequences are reported that match possible housekeeping genes. The new nucleotide sequences were deposited in the EMBL/GenBank/DDBJ database under accession numbers AF131932-AF131933, and AF132510-AF132518. KW - amylases KW - DNA cloning KW - enzyme activity KW - hyaluronidase KW - molecular genetics KW - nucleotidase KW - proteins KW - salivary glands KW - Cimex lectularius KW - Diptera KW - Lutzomyia longipalpis KW - Phlebotominae KW - Psychodidae KW - Cimex KW - Cimicidae KW - Heteroptera KW - Hemiptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Lutzomyia KW - Phlebotominae KW - Psychodidae KW - Diptera KW - apyrase KW - bed bug KW - biochemical genetics KW - phosphodiesterase KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000) KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000505113&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum. AU - Deitsch, K. W. AU - Pinal, A. del AU - Wellems, T. E. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1999/// VL - 101 IS - 1/2 SP - 107 EP - 116 SN - 0166-6851 AD - Deitsch, K. W.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990805823. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Protozoology N2 - Antigenic variation and immune evasion by Plasmodium falciparum parasitized erythrocytes are mediated by expression switches among members of the multicopy var gene family. A cluster of var genes on chromosome 12 is described that showed spontaneous recombination and switches in the transcription of individual genes. The transcription switches were not associated with sequence changes in promoter regions. Transfected episomes containing a luciferase reporter under control of a var promoter were expressed regardless of the transcriptional status of the endogenous promoter. The results suggest epigenetic regulation of var gene transcription in P. falciparum that depends on the local structure of chromatin and its associated proteins. KW - antigenic variation KW - antigens KW - chromatin KW - genes KW - immune evasion KW - luciferases KW - molecular genetics KW - parasites KW - proteins KW - recombination KW - reporter genes KW - transcription KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - antigenic polymorphism KW - antigenicity KW - biochemical genetics KW - DNA transcription KW - genetic recombination KW - immunogens KW - luciferase KW - reporter gene KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805823&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Representational difference analysis of cDNA between two Dd2 clones of Plasmodium falciparum. AU - Soubes, S. C. AU - Liu Xuan AU - Miller, L. H. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1999/// VL - 101 IS - 1/2 SP - 217 EP - 221 SN - 0166-6851 AD - Soubes, S. C.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive, NIH, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990805877. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9001-67-6. Subject Subsets: Protozoology N2 - Complementary DNA-representational difference analysis (cDNA-RDA) was used to search for a messenger RNA encoding a Plasmodium falciparum ligand involved in an alternative pathway of cell invasion (sialic acid independent) expressed by the Dd2-Nm subpopulation of the Dd2 clone. Dd2-Nm parasites appear to grow at the same rate in neuraminidase-treated erythrocytes as in normal erythrocytes, whereas treatment of erythrocytes with neuraminidase to remove sialic acid leads to a 95% reduction in invasion by the Dd2 clone which has a sialic acid-dependent pathway of cell invasion. Although the cDNA-RDA method was not able to identify the gene responsible for the sialic acid-independent pathway, the method was found useful in identifying unique messages between 2 highly related clones of P. falciparum. Nucleotide sequence data have been submitted to the EMBL, GenBank and DDJB databases under accession numbers AF091994-AF091996. KW - cell invasion KW - clones KW - complementary DNA KW - erythrocytes KW - genes KW - host parasite relationships KW - identification KW - ligands KW - messenger RNA KW - molecular genetics KW - nucleotide sequences KW - parasites KW - sialidase KW - techniques KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - blood red cells KW - cDNA KW - DNA sequences KW - exo-alpha-sialidase KW - mRNA KW - neuraminidase KW - parasite host relationships KW - red blood cells KW - sialic acid KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805877&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification of additional members define a Plasmodium falciparum gene superfamily which includes Pfs48/45 and Pfs230. AU - Templeton, T. J. AU - Kaslow, D. C. JO - Molecular and Biochemical Parasitology JF - Molecular and Biochemical Parasitology Y1 - 1999/// VL - 101 IS - 1/2 SP - 223 EP - 227 SN - 0166-6851 AD - Templeton, T. J.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990805878. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology N2 - The Plasmodium falciparum surface protein Pfs230 and the protein doublet Pfs48/45 are encoded by a single gene and share a repeated 6-cys with a conserved cysteine structure. Three new members of the 6-cys domain gene superfamily were identified in the Malaria Genome Sequencing Project databases and the P. falciparum 6-cys gene superfamily currently contains 7 members: 5 within the Pfs48/45 family and 2 within the Pfs230 family. Six-cys domains were not identified outside of Plasmodium, suggesting that the domain is specific to the genus. The new Pfs48/45-related genes were named, based on the putative MW of the deduced mature protein, as Pf36, Pf41 and Pf47. Nucleotide sequences of the genes were confirmed by polymerase chain reaction amplification and sequencing from genomic DNA of the 3D7 strain of P. falciparum. Nucleotide sequence data have been submitted to GenBank under accession number AF132898. KW - genes KW - genomes KW - molecular genetics KW - molecular weight KW - nucleotide sequences KW - parasites KW - proteins KW - surface proteins KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - DNA sequences KW - membrane proteins KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805878&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Results of the National Cooperative Inner-City Asthma Study (NCICAS) environmental intervention to reduce cockroach allergen exposure in inner-city homes. AU - Gergen, P. J. AU - Mortimer, K. M. AU - Eggleston, P. A. AU - Rosenstreich, D. AU - Mitchell, H. AU - Ownby, D. AU - Kattan, M. AU - Baker, D. AU - Wright, E. C. AU - Slavin, R. AU - Malveaux, F. JO - Journal of Allergy and Clinical Immunology JF - Journal of Allergy and Clinical Immunology Y1 - 1999/// VL - 103 IS - 3 SP - 501 EP - 506 SN - 0091-6749 AD - Gergen, P. J.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-7640, USA. N1 - Accession Number: 20000504716. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 71751-41-2. Subject Subsets: Medical & Veterinary Entomology N2 - The NCICAS intervention programme was conducted at 8 asthma study units located in 7 major metropolitan areas of the USA between 1 August and 31 October 1994. As part of this intervention, a combination of education, cleaning, and extermination with Avert (abamectin) was used in an attempt to decrease cockroach (Blattella germanica) allergen levels in the homes of 265 families who had participating asthmatic children with a positive skin test to cockroach allergen (n=515). House dust in the kitchen, bedroom and TV/living room of a random subset of 48 homes undergoing cockroach extermination treatment was collected in January, March, July and December of 1995 and analysed for Bla g 1. Samples were collected 1 week before extermination and 2, 6 and 12 months after intervention. In the kitchen the geometric mean decreased relative to preextermination levels after the 2-month visit (33.6 U/g. P<0.05). The percent of kitchens with over 8 U/g of Bla g 1 was only significant from preextermination levels to 6-month levels (86.8 vs. 64.3%, P<0.5). The geometric mean level of Bla g 1 increased in the bedroom between the preextermination and 2-month visits (8.9 vs. 11.1 U/g, P<0.05). There was no significant difference in the number of cockroach stains measured in the kitchens during preextermination, 2-, 6, and 12-month visits. It was noted that ~50% households did not comply with the instructions to prepare for the extermination. There was no significant decrease in reported problems with cockroaches between intervention and control houses after 12 months. KW - abamectin KW - allergens KW - arthropod allergies KW - asthma KW - chemical control KW - dwellings KW - environmental management KW - intervention KW - sanitation KW - USA KW - Blattaria KW - Blattella germanica KW - man KW - Blattaria KW - Dictyoptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Blattella KW - Blattellidae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - avermectin B1 KW - Blattodea KW - German cockroach KW - United States of America KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000) KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Environmental Pest Management (HH200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000504716&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Organochlorines in breast milk from two cities in Ukraine. AU - Gladen, B. C. AU - Monaghan, S. C. AU - Lukyanova, E. M. AU - Hulchiy, O. P. AU - Shkyryak-Nyzhnyk, Z. A. AU - Sericano, J. L. AU - Little, R. E. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1999/// VL - 107 IS - 6 SP - 459 EP - 462 SN - 0091-6765 AD - Gladen, B. C.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 20000403551. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 72-55-9, 50-29-3, 60-57-1, 72-20-8, 608-73-1, 76-44-8, 118-74-1. Subject Subsets: Dairy Science; Human Nutrition N2 - Reports of environmental problems in the former USSR, including excess use of pesticides, have led to concerns about high levels of contamination in humans, but little information is available to assess whether these concerns are warranted. Samples of milk from 197 women from 2 cities in the Ukraine were analysed for p,p′-DDT, p,p′-DDE, endrin, dieldrin, heptachlor epoxide, trans-nonachlor, oxychlordane, hexachlorobenzene, β-hexachlorocyclohexane (HCH), and 18 polychlorinated biphenyl congeners, and results were compared with reports from Europe. The median β-HCH concentration was 731 ng/g milk fat, which is higher than other reports from Europe but lower than reports from other parts of the world. The median DDE concentration was 2,457 ng/g milk fat, which is higher than most, but not all, other reports from Europe. Concentrations of other pesticides were comparable with, or lower than, other reports from Europe. Concentrations from the city of Kyiv were lower than those from Dniprodzerzhinsk, but the differences were small. KW - congeners KW - contamination KW - DDE KW - DDT KW - dieldrin KW - endrin KW - HCH KW - heptachlor KW - hexachlorobenzene KW - human milk KW - milk fat KW - pesticide residues KW - pesticides KW - polychlorinated biphenyls KW - women KW - Europe KW - Ukraine KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central Europe KW - Europe KW - Developed Countries KW - benzene hexachloride KW - BHC KW - breast milk KW - butterfat KW - dicophane KW - HCB KW - nonachlor KW - oxychlordane KW - p,p'-dichlorodiphenyldichloroethylene KW - PCBs KW - Milk and Dairy Produce (QQ010) KW - Physiology of Human Nutrition (VV120) KW - Human Toxicology and Poisoning (VV810) (New March 2000) KW - Food Contamination, Residues and Toxicology (QQ200) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000403551&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Medicinal herbs in the United States: research needs. AU - Matthews, H. B. AU - Lucier, G. W. AU - Fisher, K. D. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1999/// VL - 107 IS - 10 SP - 773 EP - 778 SN - 0091-6765 AD - Matthews, H. B.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 20000308940. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Horticultural Science N2 - Medicinal herbs have played a major role in the development of modern medicine and continue to be widely used in their original form. Whereas it is generally agreed that most medicinal herbs are safe under the conditions used, some are toxic and should be avoided even though they are readily available, and others have significant adverse side effects when misused. Little work has been done to investigate potential adverse effects that may be associated with extended or high-dose use of medicinal herbs. Concern has been expressed that the lack of quality control used in the preparation of medicinal herbs, plus their unregulated sale and uninformed use, pose potential adverse health effects for consumers. There is also concern regarding potential herb/herb or herb/drug interactions and possible untoward health effects of medicinal herbs in sensitive subpopulations such as the young and the elderly and certain genetically predisposed individuals. These concerns are discussed at some length. Recommendations for additional research and education with reference to USA are discussed. KW - adverse effects KW - control KW - drug interactions KW - guidelines KW - health KW - herbal drugs KW - medicinal plants KW - quality controls KW - regulations KW - safety KW - toxicity KW - toxicology KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - drug plants KW - herbal medicines KW - medicinal herbs KW - officinal plants KW - quality assurance KW - recommendations KW - rules KW - United States of America KW - Plant Composition (FF040) KW - Non-food/Non-feed Plant Products (SS200) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Laws and Regulations (DD500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000308940&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Temperature and air pollution as risk factors for heat stroke in Tokyo, July and August 1980-1995. AU - Piver, W. T. AU - Ando, M. AU - Ye, F. AU - Portier, C. J. JO - Environmental Health Perspectives JF - Environmental Health Perspectives Y1 - 1999/// VL - 107 IS - 11 SP - 911 EP - 916 CY - Research Triangle Park; USA PB - National Institute of Environmental Health Sciences SN - 0091-6765 AD - Piver, W. T.: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. N1 - Accession Number: 20003025362. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health; Soils & Fertilizers N2 - Heat stroke is associated with prolonged exposures to high air temperatures that usually occur in the summer months of July and August in Tokyo, Japan. Also during July and August, residents of Tokyo are often exposed simultaneously to high concentrations of air pollutants. To assess the impacts of these combined exposures, daily numbers of heat stroke emergency transport cases/million residents for Tokyo were stratified by gender and three groups: 0-14, 15-64, and >65 years of age, for the months of July and August in 1980-1995. A regression model was constructed using daily maximum temperature (Tmax) and daily average concentrations of NO2 and O3 as model covariates. Classification indices were added to make it possible to compare the expected number of heat stroke cases by age and gender. Lag times of 1-4 days in Tmax and air quality covariates and terms to account for interactions between pairs of model covariates were also included as additional risk factors. Generalized linear models (GLMs), assuming a Poisson error structure for heat stroke emergency transport cases, were used to determine which covariates were significant risk factors for heat stroke for the three age groups of males and females. Same-day Tmax and concentrations of NO2 were the most significant risk factors for heat stroke in all age groups of males and females. The number of heat stroke emergency transport cases/million residents was greater in males than in females in the same age groups. The smallest number of heat stroke emergency transport cases/million residents occurred for females 0-14 years of age and the greatest number of heat stroke emergency transport cases/million residents occurred for males >65 years of age. KW - air pollutants KW - air pollution KW - risk factors KW - temperature KW - Honshu KW - Japan KW - Japan KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - atmospheric pollution KW - Pollution and Degradation (PP600) KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003025362&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of a multicopy family of genes encoding a surface-expressed serine endoprotease in rat Pneumocystis carinii. AU - Russian, D. A. AU - Andrawis-Sorial, V. AU - Goheen, M. P. AU - Edman, J. C. AU - Vogel, P. AU - Turner, R. E. AU - Klivington, D. L. AU - Angus, C. W. AU - Kovacs, J. A. JO - Proceedings of the Association of American Physicians JF - Proceedings of the Association of American Physicians Y1 - 1999/// VL - 111 IS - 4 SP - 347 EP - 356 AD - Russian, D. A.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1662, USA. N1 - Accession Number: 20001202069. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 56-45-1. Subject Subsets: Medical & Veterinary Mycology N2 - The characterization of a unique family of genes encoding serine endoproteases related to the Saccharomyces cerevisiae serine endoprotease kexin was identified in P. carinii. Unlike previously described serine endoprotease genes that are single copies, multiple copies of the P. carinii serine endoprotease are distributed throughout the genome. The proteins predicted by these variant genes demonstrate sequence variability, but they retain the conserved active sites associated with endoprotease activity. The serine endoprotease was localized to the organism surface by immunohistochemical and immunofluorescence studies and to the electron lucent layer of the cyst wall by immunoelectron microscopy. The findings of multiple copies of the serine endoprotease gene in the P. carinii genome, and its localization to the cell surface, suggest that this protease plays an important role in the biology of P. carinii and that antigenic variation of the surface-expressed serine endoprotease may be a strategy for immune evasion. KW - antigens KW - genes KW - genetics KW - genomes KW - immunohistochemistry KW - proteinases KW - proteins KW - serine KW - serine proteinases KW - fungi KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis KW - Pneumocystis carinii KW - rats KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - eukaryotes KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - Pneumocystis KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Saccharomyces KW - Saccharomycetaceae KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - antigenicity KW - fungus KW - immunogens KW - proteases KW - serine proteases KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202069&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Prevalence and ethnic differences in gallbladder disease in the United States. AU - Everhart, J. E. AU - Meena Khare AU - Hill, M. AU - Maurer, K. R. JO - Gastroenterology JF - Gastroenterology Y1 - 1999/// VL - 117 IS - 3 SP - 632 EP - 639 SN - 0016-5085 AD - Everhart, J. E.: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Natcher Building, Room 6AN-12J, 45 Center Drive, MSC 6600, Bethesda, Maryland 20892-6600, USA. N1 - Accession Number: 19992012477. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health N2 - A national population-based survey was performed to determine the age, sex, and ethnic distribution of gall bladder disease in the USA. The third National Health and Nutrition Examination Survey (NHANES III) conducted gall bladder ultrasonography among a representative U.S. sample of >14 000 persons. The diagnosis of gall bladder disease by detection of gallstones or cholecystectomy was made with excellent reproducibility. An estimated 6.3 million men and 14.2 million women aged 20-74 years had gall bladder disease. Age-standardized prevalence was similar for non-Hispanic white (8.6%) and Mexican American (8.9%) men, and both were higher than non-Hispanic black men (5.3%). These relationships persisted with multivariate adjustment. Among women, age-adjusted prevalence was highest for Mexican Americans (26.7%) followed by non-Hispanic whites (16.6%) and non-Hispanic blacks (13.9%). Among women, multivariate adjustment reduced the risk of gall bladder disease for both Mexican Americans and non-Hispanic blacks compared with non-Hispanic whites. KW - biliary calculi KW - Blacks KW - disease prevalence KW - epidemiology KW - ethnic groups KW - ethnicity KW - gall bladder KW - gall bladder diseases KW - Hispanics KW - human diseases KW - risk factors KW - sex KW - sex differences KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - ethnic differences KW - gallstones KW - United States of America KW - Social Psychology and Culture (UU490) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012477&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Resolution of chronic delta hepatitis after 12 years of interferon alfa therapy. AU - Lau, D. T. Y. AU - Kleiner, D. E. AU - Park, Y. AU - Bisceglie, A. M. di AU - Hoofnagle, J. H. JO - Gastroenterology JF - Gastroenterology Y1 - 1999/// VL - 117 IS - 5 SP - 1229 EP - 1233 SN - 0016-5085 AD - Lau, D. T. Y.: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA. N1 - Accession Number: 20002005679. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9008-11-1. Subject Subsets: Public Health N2 - A 42-year-old patient with chronic delta hepatitis, referred to the Liver Diseases Section of the National Institutes of Health in Maryland, USA in April 1983, was treated with interferon-α (Intron-A; 5 million units daily) for 12 years. Serial serum samples were analysed by routine liver tests and selected samples examined for quantitative levels of hepatitis B surface antigen (HBsAg) and hepatitis delta virus RNA. Liver biopsies were performed before, during and after an initial one-year course of therapy and again after 3 and 10 years of continuous therapy. With initiation of interferon therapy, serum aminotransferase levels decreased to normal range, became abnormal again when the dose was reduced, and increased to pretreatment levels when therapy was stopped. With reinstitution and prolonged therapy, aminotransferase levels became persistently normal and after several years, both hepatitis delta virus RNA and serum HBsAg became undetectable. Liver biopsy, which initially revealed cirrhosis, showed gradual improvement in inflammatory and fibrosis scores and, after 10 years, no abnormalities or fibrosis. Therapy was stopped and the patient remained free of evidence of infection. It is concluded that long-term therapy with interferon-α in high doses led to resolution of chronic delta hepatitis, disappearance of hepatitis delta and B virus markers and improvement in fibrosis. KW - case reports KW - cirrhosis KW - drug therapy KW - fibrosis KW - hepatitis B KW - hepatitis D KW - human diseases KW - interferon KW - liver diseases KW - Maryland KW - USA KW - hepatitis B virus KW - hepatitis delta virus KW - man KW - Hepadnaviridae KW - DNA Reverse Transcribing Viruses KW - viruses KW - Deltavirus KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - liver cirrhosis KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005679&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate. AU - Baumert, T. F. AU - Vergalla, J. AU - Satoi, J. AU - Thomson, M. AU - Lechmann, M. AU - Herion, D. AU - Greenberg, H. B. AU - Ito, S. AU - Liang, T. J. JO - Gastroenterology JF - Gastroenterology Y1 - 1999/// VL - 117 IS - 6 SP - 1397 EP - 1407 SN - 0016-5085 AD - Baumert, T. F.: Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 20002009708. Publication Type: Journal Article. Language: English. Number of References: 34 ref. N2 - The generation of hepatitis C virus (HCV)-like particles (HCV-LPs) in insect cells using a recombinant baculovirus containing the complementary DNA of the HCV structural proteins has been previously described. These HCV-LPs had similar morphological and biophysical properties as the putative virions. In this study, the structural features, antigenic composition, seroreactivity, and immunogenicity of purified HCV-LPs were analysed. HCV-LPs were analysed by electron microscopy and antibody immunolabelling and precipitation. An ELISA using HCV-LPs was developed. The humoral response to HCV-LPs in mice was studies by core and envelope ELISAs, Western immunoblotting, and immunofluorescence. Structural and antigenic compositions of HCV-LPs were shown to be similar to those of putative HCV virions. Using the HCV-LP ELISA, high-titre anti-HCV antibodies were detected in individuals infected with various HCV genotypes. In vivo, HCV-LPs elicited a humoral response broadly directed against HCV structural proteins. It is concluded that HCV-LPs resemble HCV virions and are capable of inducing a humoral response targeted against various regions of HCV structural proteins, suggesting that HCV-LPs may be promising as a potential vaccine candidate. KW - hepatitis C KW - human diseases KW - immune response KW - vaccine development KW - vaccines KW - viral structural proteins KW - virus-like particles KW - hepatitis C virus KW - man KW - mice KW - Hepacivirus KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - immunity reactions KW - immunogenicity KW - immunological reactions KW - Host Resistance and Immunity (HH600) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009708&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Low-grade monoclonal Epstein-Barr virus-associated lymphoproliferative disorder of the brain presenting as human immunodeficiency virus-associated encephalopathy in a child with acquired immunodeficiency syndrome. AU - Kingma, D. W. AU - Mueller, B. U. AU - Frekko, K. AU - Sorbara, L. R. AU - Wood, L. V. AU - Katz, D. AU - Raffeld, M. AU - Jaffe, E. S. JO - Archives of Pathology and Laboratory Medicine JF - Archives of Pathology and Laboratory Medicine Y1 - 1999/// VL - 123 IS - 1 SP - 83 EP - 87 SN - 0003-9985 AD - Kingma, D. W.: Hematopathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-1500, USA. N1 - Accession Number: 19992005011. Publication Type: Journal Article. Language: English. Number of References: 33 ref. N2 - A case is reported of an 8-year-old HIV-positive girl from the USA, who developed a lesion in the central nervous system that appeared to be histologically reactive and that proved to be an Epstein-Barr virus-associated monoclonal B-cell lymphoproliferative disorder by molecular analysis. The patient was diagnosed with vertically transmitted HIV infection at age 5, for which she was treated empirically with a combination of zidovudine and didanosine. At the age of 7 years, during evaluation for entry into an antiretroviral protocol, a single hypodense frontal lobe lesion was identified by computed tomography. After unsuccessful treatment for presumed toxoplasmosis and progressive neurological deterioration, a stereotactic brain biopsy was performed. Although the biopsy contained a polymorphic lymphoid infiltrate that appeared to be cytologically reactive, polymerase chain reaction and in situ hybridization studies revealed a monoclonal Epstein-Barr virus-associated B-cell lymphoproliferative disorder, which was reminiscent of polymorphic B-cell hyperplasia observed in the setting of immunosuppression following organ transplantation. Postoperative therapy included steroids and antiretroviral therapy. The lesion decreased slightly in size, and the child's neurological status was relatively unremarkable for 5 months. Subsequently, she developed cytomegalovirus retinitis, progressive encephalopathy and died with pancytopenia. KW - acquired immune deficiency syndrome KW - brain KW - case reports KW - children KW - clinical aspects KW - diagnosis KW - encephalopathy KW - girls KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - mixed infections KW - opportunistic infections KW - viral diseases KW - USA KW - Human herpesvirus 4 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Lymphocryptovirus KW - Gammaherpesvirinae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Human herpesvirus 4 KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - cerebrum KW - clinical picture KW - Epstein-Barr virus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - multiple infections KW - United States of America KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005011&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progressive multifocal leukoencephalopathy and JC virus genotypes in West African patients with acquired immunodeficiency syndrome: a pathologic and DNA sequence analysis of 4 cases. AU - Chima, S. C. AU - Agostini, H. T. AU - Ryschkewitsch, C. F. AU - Lucas, S. B. AU - Stoner, G. L. JO - Archives of Pathology and Laboratory Medicine JF - Archives of Pathology and Laboratory Medicine Y1 - 1999/// VL - 123 IS - 5 SP - 395 EP - 403 SN - 0003-9985 AD - Chima, S. C.: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992007058. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Tropical Diseases N2 - Cases of progressive multifocal leukoencephalopathy are reported in 4 HIV-positive patients from Côte d'Ivoire, and the viral genotypes are analysed. Immunohistochemical staining by labelled streptavidin-biotin for capsid protein antigen was performed on all cases. Polymerase chain reaction amplification of viral genomic DNA was followed by direct cycle sequencing. JC virus type 3 was identified in 2 cases, and type 6 was isolated in 1 case. The viral regulatory region from 1 case showed an uncommon rearrangement pattern. It is concluded that progressive multifocal leukoencephalopathy in West African patients with AIDS is caused by African genotypes of JC virus (types 3 and 6). The prevalence of disease in this postmortem examination series from sub-Saharan Africa (1.5%) was less than has been reported from Europe and the United States (4-10%) and it is suggested that this may be partly due to biological differences in JC virus genotypes. KW - acquired immune deficiency syndrome KW - case reports KW - encephalitis KW - encephalopathy KW - genetics KW - genotypes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - opportunistic infections KW - pathology KW - progressive multifocal leukoencephalopathy KW - viral diseases KW - Cote d'Ivoire KW - JC polyomavirus KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Polyomavirus KW - Polyomaviridae KW - dsDNA viruses KW - DNA viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Developing Countries KW - Francophone Africa KW - Africa KW - West Africa KW - Africa South of Sahara KW - AIDS KW - encephalomyelitis KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Ivory Coast KW - JC virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007058&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels. AU - Mahmoodian, F. AU - Peterkofsky, B. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1999/// VL - 129 IS - 1 SP - 83 EP - 91 SN - 0022-3166 AD - Mahmoodian, F.: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 20001410520. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 50-81-7, 61912-98-9. Subject Subsets: Human Nutrition N2 - Ascorbic acid deficiency causes morphologic changes in the endothelial and smooth muscle compartments of guinea pig blood vessels. Endothelial cells synthesize the basement membrane components, type IV collagen and laminin, and smooth muscle cells synthesize elastin in blood vessels. Therefore, the possibility that ascorbic acid deficiency affects the expression of these proteins was examined. Decreased expression of types I and II collagens in other tissues of ascorbic acid-deficient guinea pigs is associated with weight loss and the consequent induction of insulin-like growth factor binding proteins; thus food deprivation to induce weight loss was used also. Female guinea pigs received a ascorbic acid-free diet, supplemented orally with ascorbate. Ascorbic acid-deficient guinea pigs received the same diet but no ascorbate, and the food-deprived group received no food, but were supplemented with ascorbic acid. Concentrations of mRNAs for basement membrane components and elastin in blood vessels were measured by Northern blotting; overall basement membrane metabolism was assessed by measuring immunoreactive laminin and type IV 7S collagen in serum. Laminin mRNA in blood vessels and serum laminin concentrations were unaffected by ascorbic acid deficiency. Concentrations of type IV collagen and elastin mRNAs in blood vessels were not affected in moderately scorbutic guinea pigs (0-7% weight loss), but with increased weight loss, type IV collagen mRNA was 57% (P<0.05) and elastin mRNA was 3% (P<0.01) of normal values. In food-deprived guinea pigs, type IV collagen mRNA was 51% (P<0.05) and elastin mRNA was 35% (P<0.05) of normal. Serum type IV 7S collagen concentrations were 25% of normal in scorbutic guinea pigs with extensive weight loss. The lower expression of type IV collagen and elastin mRNAs in blood vessels may contribute to defects observed in blood vessels during scurvy. KW - ascorbic acid KW - binding proteins KW - blood vessels KW - collagen KW - deficiency KW - deficiency diseases KW - deprivation KW - endothelium KW - food deprivation KW - growth factors KW - insulin-like growth factor KW - messenger RNA KW - muscles KW - scurvy KW - supplements KW - weight losses KW - guineapigs KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - carrier proteins KW - guinea pigs KW - mRNA KW - somatomedin C KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410520&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically. AU - Trøen, G. AU - Eskild, W. AU - Fromm, S. H. AU - Luca, L. M. de AU - Ong, D. E. AU - Wardlaw, S. A. AU - Reppe, S. AU - Blomhoff, R. JO - Journal of Nutrition JF - Journal of Nutrition Y1 - 1999/// VL - 129 IS - 9 SP - 1621 EP - 1627 SN - 0022-3166 AD - Trøen, G.: Institute for Nutrition Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. N1 - Accession Number: 20001416826. Publication Type: Journal Article. Language: English. Registry Number: 68-26-8. Subject Subsets: Human Nutrition; Agricultural Biotechnology N2 - The suggested function of cellular retinol-binding protein type I [CRBP(I)] is to carry retinol to esterifying or oxidizing enzymes. The retinyl esters are used in storage or transport, whereas oxidized forms such as all-trans or 9-cis retinoic acid are metabolites used in the mechanism of action of vitamin A. Thus, high expression of human CRBP(I) [hCRBP(I)] in transgenic mice might be expected to increase the production of retinoic acid in tissues, thereby inducing a phenotype resembling vitamin A toxicity. Alternatively, a vitamin A-deficient phenotype could also be envisioned as a result of an increased accumulation of vitamin A in storage cells induced by a high hCRBP(I) level. Signs of vitamin A toxicity or deficiency were therefore examined in tissues from transgenic mice with ectopic expression of hCRBP(I). Testis and intestine, the tissues with the highest expression of the transgene, showed normal gross morphology. Similarly, no abnormalities were observed in other tissues known to be sensitive to vitamin A status such as cornea and retina, and the epithelia in the cervix, trachea and skin. Furthermore, hematologic variables known to be influenced by vitamin A status as the hemoglobin concentration, haematocrits and the number of red blood cells were within normal ranges in the transgenic mice. In conclusion, these transgenic mice have normal function of vitamin A despite high expression of hCRBP(I) in several tissues. KW - binding proteins KW - genetically engineered organisms KW - phenotypes KW - retinol KW - tissues KW - transgenic animals KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - axerophthol KW - carrier proteins KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416826&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Recent advances in varicella-zoster virus infection. AU - Cohen, J. I. AU - Brunell, P. A. AU - Straus, S. E. AU - Krause, P. R. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1999/// VL - 130 IS - 11 SP - 922 EP - 932 SN - 0003-4819 AD - Cohen, J. I.: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA. N1 - Accession Number: 19992009697. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 104 ref. Subject Subsets: Public Health N2 - An edited summary of a Clinical Staff Conference held on 27 May 1998 at the National Institutes of Health, Bethesda, Maryland, USA, is presented. The molecular biology and immunology of varicella-zoster virus (VZV) including transmission, clinical features and diagnosis of varicella and zoster, management of varicella, zoster and postherpetic neuralgia, and prevention of varicella and zoster are reviewed. KW - clinical aspects KW - diagnosis KW - drug therapy KW - herpes zoster KW - human diseases KW - immunology KW - molecular biology KW - pathogenesis KW - prevention KW - reviews KW - shingles KW - transmission KW - viral diseases KW - Human herpesvirus 3 KW - man KW - viruses KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Varicellovirus KW - Alphaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - clinical picture KW - neuralgia KW - varicella-zoster virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009697&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasma HIV viral load in patients with hemophilia and late-stage HIV disease: a measure of current immune suppression. AU - Engels, E. A. AU - Rosenberg, P. S. AU - O'Brien, T. R. AU - Goedert, J. J. JO - Annals of Internal Medicine JF - Annals of Internal Medicine Y1 - 1999/// VL - 131 IS - 4 SP - 256 EP - 264 SN - 0003-4819 AD - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8005, Rockville, MD 20822, USA. N1 - Accession Number: 19992012017. Publication Type: Journal Article. Corporate Author: Multicenter Hemophilia Cohort Study Language: English. Number of References: 36 ref. Subject Subsets: Public Health N2 - A retrospective cohort study was conducted to evaluate the relation between plasma HIV viral load and subsequent risk for disease progression in patients with late-stage HIV disease. 389 patients with haemophilia and late-stage HIV disease (CD4 count<200 cells/mm³) at 16 treatment centres for patients with haemophilia in the USA and Europe were included in the study. Plasma HIV viral load was measured at baseline. Patients were followed for AIDS-related illnesses (primary outcome) and, specifically, Pneumocystis carinii pneumonia (secondary outcome). HIV viral load strongly predicted AIDS-related illness. For patients with viral loads <4.00 log10 copies/ml, the one-year actuarial risk was 0% and the 5-year risk was 25%. For patients with viral loads of ≥6.00 log10 copies/ml, the one-year actuarial risk was 42% and the 5-year risk was 78%. A linear relation existed between viral load and risk for AIDS-related illness (hazard ratio, 2.37 per log10 copies/ml; P<0.001). In addition, viral load most strongly predicted risk for illness immediately after viral load testing; this predictive relation attenuated over time (P=0.002). These findings changed little after adjustment for CD4 cell counts that were updated during follow-up. In the first year after viral load was measured, it predicted occurrence of P. carinii pneumonia (hazard ratio, 4.69 per log10 copies/ml; P<0.001). It is concluded that in patients with haemophilia and late-stage HIV disease, viral load predicts disease progression independently of CD4 cell counts. Because viral load most strongly predicts progression immediately after load is measured, it seems to reflect the current level of immunosuppression. KW - acquired immune deficiency syndrome KW - disease course KW - haemophilia KW - human diseases KW - human immunodeficiency viruses KW - immunosuppression KW - Pneumocystis carinii pneumonia KW - prognosis KW - viral load KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - AIDS KW - disease progression KW - fungus KW - hemophilia KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012017&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Randomized trial of "slow" versus "fast" feed advancements on the incidence of necrotizing enterocolitis in very low birth weight infants. AU - Rayyis, S. F. AU - Ambalavanan, N. AU - Wright, L. AU - Carlo, W. A. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1999/// VL - 134 IS - 3 SP - 293 EP - 297 SN - 0022-3476 AD - Rayyis, S. F.: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, and National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 19991407068. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition N2 - The hypothesis that in very low birth weight (VLBW) infants, slow feed advancement (15 cc/kg per day) would decrease the overall incidence of necrotizing enterocolitis (NEC) compared with fast feed advancement (35 cc/kg per day) was tested in a randomized controlled trial. 185 formula fed infants with birth weights ranging from 501-1500 g and gestational age ≤34 weeks were randomized to either the fast or slow feeding protocols using Similac Special Care (20 cal/oz). The incidence of NEC was not significantly different between the groups (Bell stage≥II, slow 13%, fast 9%, Bell stage III (perforation) slow 4%, fast 2%). It is concluded that a doubling in the rate of feed advancement in pre-term low birth weight infants did not affect the incidence of NEC, but did cause infants to regain their birth weight earlier. KW - clinical trials KW - enteral feeding KW - enterocolitis KW - infants KW - low birth weight infants KW - neonatal necrotizing enterocolitis KW - premature infants KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - United States of America KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407068&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Viral infections in interferon-γ receptor deficiency. AU - Dorman, S. E. AU - Uzel, G. AU - Roesler, J. AU - Bradley, J. S. AU - Bastian, J. AU - Billman, G. AU - King, S. AU - Filie, A. AU - Schermerhorn, J. AU - Holland, S. M. JO - Journal of Pediatrics JF - Journal of Pediatrics Y1 - 1999/// VL - 135 IS - 5 SP - 640 EP - 643 SN - 0022-3476 AD - Dorman, S. E.: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institues of Health, Bethesda, Maryland, USA. N1 - Accession Number: 20002005056. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health N2 - Cases of severe viral infections are reported in 4 patients [USA] with interferon-α (IFN-α) receptor deficiency and mycobacterial disease [date not given]. The mycobacterial pathogens included Mycobacterium avium, M. fortuitum and M. kansasii and the viral pathogens included respiratory syncytial virus, herpes simplex virus, parainfluenza virus type 3 and varicella-zoster virus. It is concluded that although disseminated infection with non-tuberculous mycobacteria is the most common clinical presentation of IFN-α receptor deficiency, the frequency and severity of viral infections may also be increased in patients with this primary immunodeficiency. IFN-α receptor deficiency should be included in the differential diagnosis in children with severe viral infections. KW - herpes simplex KW - herpes simplex viruses KW - human diseases KW - human herpesviruses KW - immunocompromised hosts KW - immunological deficiency KW - mycobacterial diseases KW - opportunistic infections KW - varicella KW - viral diseases KW - USA KW - Human herpesvirus 3 KW - human respiratory syncytial virus KW - man KW - Mycobacterium KW - Mycobacterium avium KW - Mycobacterium fortuitum KW - Mycobacterium kansasii KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Varicellovirus KW - Alphaherpesvirinae KW - viruses KW - Pneumovirus KW - Paramyxoviridae KW - Mononegavirales KW - negative-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - Pneumovirinae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - Paramyxovirinae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - chicken pox KW - herpes simplex virus KW - Human herpesvirus KW - immune deficiency KW - immunodeficiency KW - mycobacterial infections KW - parainfluenza 3 virus KW - United States of America KW - varicella-zoster virus KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005056&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary factors and the risk of gastric cancer in Mexico City. AU - Ward, M. H. AU - López Carrillo, L. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1999/// VL - 149 IS - 10 SP - 925 EP - 932 SN - 0002-9262 AD - Ward, M. H.: Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD., USA. N1 - Accession Number: 19991410382. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition; Dairy Science N2 - A population-based case-control study of gastric cancer in the metropolitan area of Mexico City was carried out in 1989-1990. 220 patients with histologically confirmed gastric adenocarcinomas were interviewed. Controls were an age-stratified random sample of residents of Mexico City. The dietary questionnaire was a 70-item semi-quantitative food frequency adapted for the Mexican diet. Odds ratios were calculated for quartiles of consumption of food groups and were adjusted for age, gender, calories, chilli pepper intake, cigarette smoking, socioeconomic status, added salt, and history of peptic ulcer disease. There was approximately a threefold increased risk of gastric cancer for frequent consumption (highest quartile) of both fresh meat (odds ratio (OR) = 3.1) and processed meat (OR = 3.2). Odds ratios were also significantly increased for frequent consumption of milk products (OR = 2.7) and fish (OR = 2.2). There was a decreasing gradient of risk with increasing frequency of vegetable consumption due to a significant inverse trend for the yellow and orange vegetables. High intake of citrus fruits showed a slight inverse association. Consumption of salty snacks more than twice per month was associated with an 80% increased risk, and there was a significant positive trend. These findings are consistent with many studies around the world that indicate important roles for salt, processed meats, and vegetable consumption in gastric cancer risk. KW - chillies KW - diet KW - diet studies KW - dietary history KW - digestive tract KW - intake KW - meat KW - milk products KW - neoplasms KW - processed products KW - risk KW - risk factors KW - salt KW - socioeconomic status KW - stomach KW - tobacco smoking KW - ulcers KW - vegetables KW - Mexico KW - Capsicum KW - man KW - Solanaceae KW - Solanales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developing Countries KW - Latin America KW - America KW - North America KW - OECD Countries KW - Threshold Countries KW - cancers KW - dairy products KW - food history KW - gastrointestinal tract KW - vegetable crops KW - Diet Studies (VV110) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Milk and Dairy Produce (QQ010) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410382&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. AU - Cantor, K. P. AU - Lynch, C. F. AU - Hildesheim, M. E. AU - Dosemeci, M. AU - Lubin, J. AU - Alavanja, M. AU - Craun, G. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1999/// VL - 150 IS - 6 SP - 552 EP - 560 SN - 0002-9262 AD - Cantor, K. P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8106, Bethesda, MD 20892-7240, USA. N1 - Accession Number: 20002007919. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 7782-50-5. N2 - The authors conducted a population-based case-control study in Iowa, USA of 375 brain cancer patients and 2434 controls. A postal questionnaire was used to gather information on lifetime residential history, sources of drinking water, beverage intake, and other potential risk factors. Exposure to chlorination byproducts in drinking water was estimated by combining questionnaire data with historical information from water utilities and trihalomethane levels in recent samples. The analysis included 291 cases (77.6%) and 1983 controls (81.5%), for whom water quality information was available for at least 70% of lifetime years. Proxies represented 74.4% of cases. The mean number and mean duration of places of residence were comparable between direct and proxy respondents, suggesting little contribution to bias. After multivariate adjustment, odds ratios for brain cancer were 1.0, 1.1, 1.6, and 1.3 for exposure to chlorinated surface water of 0, 1-19, 20-39, and ≥40 years (p trend = 0.1). Among men, odds ratios were 1.0, 1.3, 1.7 and 2.5 (p trend = 0.04), and among women, 1.0, 1.0, 1.6, and 0.7 (p trend = 0.7). Similar findings were found with estimates of average lifetime level of trihalomethanes. The association was stronger among men with above-median tap water consumption. These observations deserve further attention, especially in view of increasing glioma rates. KW - brain KW - chlorination KW - chlorine KW - drinking water KW - human diseases KW - men KW - neoplasms KW - risk factors KW - women KW - Iowa KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Corn Belt States of USA KW - North Central States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - West North Central States of USA KW - cancers KW - cerebrum KW - trihalomethanes KW - United States of America KW - Water Resources (PP200) KW - Human Health and the Environment (VV500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007919&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Implications of a new dietary measurement error model for estimation of relative risk: application to four calibration studies. AU - Kipnis, V. AU - Carroll, R. J. AU - Freedman, L. S. AU - Li Li JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1999/// VL - 150 IS - 6 SP - 642 EP - 651 SN - 0002-9262 AD - Kipnis, V.: Biometry Branch, Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Room 344, 6130 Executive Blvd., MSC 7354, Bethesda, MD 20892-7354, USA. N1 - Accession Number: 20001406251. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition N2 - Food records or 24-h recalls are currently used to calibrate food frequency questionnaires (FFQ) and to correct disease risks for measurement error. The standard regression calibration approach requires that these reference measures contain only random within-person errors uncorrelated with errors in FFQ. Increasing evidence suggests that records/recalls are likely to be also flawed with systematic person-specific biases, so that for any individual the average of multiple replicate assessments may not converge to her/his true usual nutrient intake. A new measurement error model is proposed to accommodate person-specific bias in the reference measure and its correlation with systematic error in the FFQ. Sensitivity analysis using calibration data from 4 studies demonstrated that failure to account for person-specific bias in the reference measure can often lead to substantial underestimation of the relative risk for a nutrient. It is concluded that in the absence of information on the extent of person-specific biases in reference instruments and their relation to biases in FFQ, the adequacy of the standard methods of correcting relative risks for measurement error is in question, as is the interpretation of negative findings from nutritional epidemiology such as failure to detect an important relation between fat intake and breast cancer. KW - analytical methods KW - calibration KW - diet studies KW - diet study techniques KW - epidemiology KW - intake KW - nutrients KW - questionnaires KW - regression analysis KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - analytical techniques KW - Techniques and Methodology (ZZ900) KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406251&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Epidemiology of rotavirus diarrhea in Egyptian children and implications for disease control. AU - Naficy, A. B. AU - Abu-Elyazeed, R. AU - Holmes, J. L. AU - Rao, M. R. AU - Savarino, S. J. AU - Kim YongDai AU - Wierzba, T. F. AU - Peruski, L. AU - Lee, Y. J. AU - Gentsch, J. R. AU - Glass, R. I. AU - Clemens, J. D. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1999/// VL - 150 IS - 7 SP - 770 EP - 777 SN - 0002-9262 AD - Naficy, A. B.: Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. N1 - Accession Number: 20002004780. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Tropical Diseases N2 - A study was conducted to describe the epidemiology of rotavirus diarrhoea in a population-based cohort of children <3 years of age residing in Abu Homos, Egypt, during 1995-96. Rotavirus diarrhoea incidence rates (episodes per person-year) were 0.13 for infants aged <6 months, 0.61 for those aged 6-11 months, 0.17 for those aged 12-23 months and 0.15 for those aged 24-35 months. 56% of children with rotavirus diarrhoea had clinical dehydration; 90% of rotavirus diarrhoeal episodes occurred between July and November. In infants less than 1 year of age, receipt of breast milk was associated with a lower incidence of rotavirus diarrhoea. No other sociodemographic or environmental factor was significantly associated with rotavirus diarrhea. Of 46 rotavirus isolates with strains identified, 41 (89%) were G serotypes 1 and 2. Rotavirus diarrhoea was a major cause of morbidity in this cohort. It is suggested that promotion of breastfeeding may exert a protective effect in young infants in this setting, but improvements in water and sanitation are unlikely to be effective preventive measures. The use of effective immunization against rotavirus in early infancy should be considered a public health priority. KW - breast feeding KW - children KW - clinical aspects KW - diarrhoea KW - disease control KW - disease prevalence KW - epidemiology KW - human diseases KW - infants KW - morbidity KW - risk factors KW - seasonal variation KW - serotypes KW - strains KW - Egypt KW - man KW - Rotavirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Reoviridae KW - dsRNA viruses KW - RNA viruses KW - viruses KW - Developing Countries KW - Mediterranean Region KW - Middle East KW - North Africa KW - Africa KW - clinical picture KW - diarrhea KW - Misr KW - scouring KW - seasonal changes KW - seasonal fluctuations KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004780&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Longitudinal change in height of men and women: implications for interpretation of the body mass index. The Baltimore Longitudinal Study of Aging. AU - Sorkin, J. D. AU - Muller, D. C. AU - Andres, R. JO - American Journal of Epidemiology JF - American Journal of Epidemiology Y1 - 1999/// VL - 150 IS - 9 SP - 969 EP - 977 SN - 0002-9262 AD - Sorkin, J. D.: Metabolism Section, Laboratory of Clinical Investigation, Intramural Research Program, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA. N1 - Accession Number: 20001407568. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition N2 - 2084 men and women aged 17-94 years enrolled from 1958 to 1993 in the Baltimore Longitudinal Study of Aging were studied. On average, men's height was measured 9 times during 15 years and women's height 5 times during 9 years. The rate of decrease in height was greater for women than for men. For both sexes, height loss began at about 30 years of age and accelerated with increasing age. Cumulative height loss from 30 to 70 years of age averaged about 3 cm for men and 5 cm for women; by 80 years of age, it increased to 5 cm for men and 8 cm for women. This degree of height loss would account for an "artefactual" increase in body mass index of approximately 0.7 kg/m² for men and 1.6 kg/m² for women by 70 years of age that increases to 1.4 and 2.6 kg/m², respectively, by 80 years of age. It is concluded that true height loss with aging must be taken into account when height (or indexes based on height) is used in physiologic or clinical studies. KW - aging KW - anthropometric dimensions KW - body weight KW - elderly KW - height KW - men KW - old age KW - sex differences KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - aged KW - ageing KW - anthropometric measurements KW - elderly people KW - older adults KW - senior citizens KW - Human Nutrition (General) (VV100) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Current approaches to diagnosis and treatment of fungal infections in children infected with human immuno deficiency virus. AU - Müller, F. M. C. AU - Groll, A. H. AU - Walsh, T. J. JO - European Journal of Pediatrics JF - European Journal of Pediatrics Y1 - 1999/// VL - 158 IS - 3 SP - 187 EP - 199 SN - 0340-6199 AD - Müller, F. M. C.: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991202018. Publication Type: Journal Article. Language: English. Number of References: 111 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Current knowledge of epidemiology, clinical presentation, diagnosis and treatment of mucosal and invasive fungal infections in children and adolescents with human immunodeficiency virus is reviewed. Infections caused by Candida spp., Cryptococcus neoformans, Aspergillus spp., Histoplasma capsulatum, Coccidioides immitis, Penicillium marneffei, Pneumocystis carinii and other fungi are discussed. KW - adolescents KW - aspergillosis KW - candidosis KW - children KW - clinical aspects KW - coccidioidomycosis KW - cryptococcosis KW - diagnosis KW - drug therapy KW - epidemiology KW - histoplasmosis KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - infections KW - mycoses KW - opportunistic infections KW - pneumocystosis KW - predisposition KW - reviews KW - Aspergillus KW - Candida KW - Coccidioides immitis KW - Cryptococcus neoformans KW - Histoplasma capsulatum KW - man KW - Penicillium marneffei KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Ajellomyces KW - Ajellomycetaceae KW - Onygenales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Trichocomaceae KW - Eurotiales KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Coccidioides KW - Onygenaceae KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - Histoplasma KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Penicillium KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ajellomyces capsulatus KW - candidiasis KW - chemotherapy KW - clinical picture KW - coccidiomycosis KW - european blastomycosis KW - fungus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Hyphomycetes KW - teenagers KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202018&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-γ-dependent effector mechanisms. AU - Jankovic, D. AU - Wynn, T. A. AU - Kullberg, M. C. AU - Hieny, S. AU - Caspar, P. AU - James, S. AU - Cheever, A. W. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 162 IS - 1 SP - 345 EP - 351 SN - 0022-1767 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, Bldg. 4/126, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990803611. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9008-11-1. Subject Subsets: Helminthology N2 - In order to investigate the respective contributions of the B lymphocyte- and IFN-γ-dependent effector arms in host resistance to Schistosoma mansoni, vaccine-induced immunity (using radiation-attenuated cercariae) was compared in B cell-deficient (µMT, KO) and IFN (interferon)-γ knockout (GKO) mice. Unexpectedly, after a single vaccination, B cell knockout (KO) mice displayed less protection (P<0.005) against challenge infection, compared with control mice, although they developed a normal IFN-γ-dominated cytokine response giving them partial protection. This defect in resistance was equivalent to that displayed by GKO animals. Moreover, whereas 2 additional vaccinations significantly increased the level of immunity in wild-type mice (P<0.02), the protection in B cell KO animals remained unchanged. In contrast, multiple vaccination resulted in increased, although still defective, resistance in GKO mice. Since FcR γ KO mice, which lack functional FcγRI, FcγRIII, and FcεRI, showed no defects in vaccine-induced resistance after immunization either one or 3 times, the B cell-dependent mechanism of protection involved does not appear to require FcR signalling. Together, these findings indicate that effective vaccination against schistosomes depends on the simultaneous induction of both humoral and cell-mediated immunity, a conclusion that may explain the limited success of most subunit vaccine protocols designed to preferentially induce either B cell- or IFN-γ-dependent protective mechanisms. KW - animal diseases KW - B lymphocytes KW - cell mediated immunity KW - experimental infections KW - helminths KW - human diseases KW - humoral immunity KW - immune response KW - immunity KW - immunization KW - interferon KW - laboratory animals KW - parasites KW - vaccination KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - B cells KW - cellular immunity KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803611&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. AU - Chiaramonte, M. G. AU - Schopf, L. R. AU - Neben, T. Y. AU - Cheever, A. W. AU - Donaldson, D. D. AU - Wynn, T. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 162 IS - 2 SP - 920 EP - 930 SN - 0022-1767 AD - Chiaramonte, M. G.: Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990803438. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Registry Number: 37341-29-0, 9008-11-1, 207137-56-2, 148157-34-0. Subject Subsets: Helminthology N2 - Schistosoma mansoni egg-induced pulmonary granuloma formation is a cell-mediated inflammatory response associated with dominant Th2-type cytokine expression, tissue eosinophilia and high levels of serum IgE. It was shown that in vivo blockade of the Th2 cytokine interleukin (IL)-13, using soluble IL-13R α2-Fc fusion protein, significantly reduced the size of pulmonary granulomas in unsensitized as well as egg-sensitized mice. Blocking IL-13 also significantly reduced total serum IgE levels. However, IL-13 blockade did not affect the evolving egg-induced Th2-type cytokine response. IL-4 and IL-5, as well as IL-13, responses were indistinguishable in control-Fc- and soluble IL-13R α2-Fc fusion protein-treated animals. The smaller granulomas were also phenotypically like the control Fc-treated mice, displaying a similar eosinophil content. Additional studies in IL-4-deficient mice demonstrated that IL-13 was produced, but at much lower levels than in wild-type mice, while IL-4 expression was completely independent of IL-13. While granuloma formation was partially reduced in IL-4-deficient mice, blocking IL-13 almost completely abrogated granuloma development and pulmonary eosinophilia, while it simultaneously increased interferon (IFN)-γ production. The results show that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs. KW - cell mediated immunity KW - cytokines KW - eosinophilia KW - experimental infections KW - granuloma KW - helminth ova KW - helminths KW - IgE KW - immune response KW - inflammation KW - interferon KW - interleukin 13 KW - interleukin 4 KW - interleukin 5 KW - interleukins KW - laboratory animals KW - lungs KW - parasites KW - recombinant proteins KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - cellular immunity KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - reagin KW - reaginic antibodies KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990803438&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains. AU - Noben-Trauth, N. AU - Paul, W. E. AU - Sacks, D. L. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 162 IS - 10 SP - 6132 EP - 6140 SN - 0022-1767 AD - Noben-Trauth, N.: Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, Twinbrook II, Room 125, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA. N1 - Accession Number: 19990805938. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 9008-11-1, 207137-56-2, 148157-34-0. Subject Subsets: Protozoology N2 - Using BALB/c mice deficient in interleukin (IL)-4 (IL-4-/-) or IL-4 receptor α-chain (IL-4Rα-/-), different disease outcomes to Leishmania major infection were observed depending on parasite substrain. Infection with L. major LV39 caused progressive nonhealing ulcers and uncontrolled parasite growth in both IL-4-/- and IL-4Rα-/- mice. In contrast, infection with L. major IR173 was partially controlled in IL-4-/- mice but efficiently controlled in IL-4Rα-/- mice. Both IL-4-/- and IL-4Rα-/- mice infected with either substrain displayed reduced Th2 responses. Interferon (IFN)-γ secretion was not up-regulated in the mutant mice, even in IL-4Rα-/- mice which were resistant to L. major IR173. Lack of increased IFN-γ production suggests that cytokine cross-regulation may not be operating in this model and that the effective ratios of Th1/Th2 cytokines become more indicative of disease outcome. The partial versus complete resistance to IR173 in IL-4-/- or IL-4Rα-/- mice implies that, in addition to IL-4, IL-13 may be involved in disease progression during L. major infection. The results with LV39 infection indicate that yet another unidentified factor is capable of causing susceptibility to L. major in the absence of IL-4 or IL-4 signalling. KW - cytokines KW - disease course KW - disease resistance KW - experimental infections KW - immune response KW - interferon KW - interleukin 13 KW - interleukin 4 KW - laboratory animals KW - parasites KW - receptors KW - strain differences KW - strains KW - susceptibility KW - T lymphocytes KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - disease progression KW - immunity reactions KW - immunological reactions KW - resistance to disease KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805938&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera. AU - Scala, G. AU - Chen XueNi AU - Liu WeiMin AU - Telles, J. N. AU - Cohen, O. J. AU - Vaccarezza, M. AU - Igarashi, T. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 162 IS - 10 SP - 6155 EP - 6161 SN - 0022-1767 AD - Scala, G.: Laboratory of Immunoregulation/National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1576, USA. N1 - Accession Number: 19992009587. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - Random peptide libraries were screened using sera from HIV-infected subjects to identify antigenic and immunogenic mimics of HIV-1 epitopes. After extensive counterscreening with HIV-negative sera, peptides specifically recognized by Abs from HIV-1-infected individuals were isolated. These peptides behaved as antigenic mimics of linear or conformational HIV-1 epitopes generated in vivo in infected subjects. Consistent with these findings, sera of simian HIV-infected monkeys also recognized the HIV-specific epitopes. The selected peptides were immunogenic in mice, where they elicited HIV-specific Abs that effectively neutralized HIV-1 isolates. These results demonstrated that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection. KW - antigenic variation KW - antigens KW - envelope proteins KW - epitopes KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunogenetics KW - immunology KW - peptides KW - viral diseases KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - antigenic determinants KW - antigenic polymorphism KW - antigenicity KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunogens KW - viral infections KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009587&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Induction of HIV-1 replication by allogeneic stimulation. AU - Moriuchi, H. AU - Moriuchi, M. AU - Fauci, A. S. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 162 IS - 12 SP - 7543 EP - 7548 SN - 0022-1767 AD - Moriuchi, H.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19992011596. Publication Type: Journal Article. Language: English. Number of References: 38 ref. N2 - Allogeneic stimulation presents an immunologic challenge during pregnancy, blood transfusions, and transplantations, and has been associated with reactivation of latently infected virus such as CMV. Since HIV-1 is transmitted vertically, sexually, or via contaminated blood, the effects of allostimulation on HIV-1 infection were tested. It was shown that (1) allostimulated lymphocytes are highly susceptible to acute infection with T cell-tropic or dual-tropic HIV-1; (2) allostimulation has dichotomous effects on replication of macrophage-tropic HIV-1 - it activates HIV expression in already infected cells but inhibits HIV entry by secreting HIV-suppressive CC chemokines; (3) allogeneic stimulation of latently infected, resting CD4+ T cells induced replication of HIV-1 in these cells. These observations suggest that allogeneic stimulation may play a role in the transmission, replication, and phenotypic transition of HIV-1. KW - human diseases KW - human immunodeficiency viruses KW - immunology KW - lymphocytes KW - replication KW - stimulation KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011596&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. AU - Jankovic, D. AU - Kullberg, M. C. AU - Noben-Trauth, N. AU - Caspar, P. AU - Ward, J. M. AU - Cheever, A. W. AU - Paul, W. E. AU - Sher, A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 163 IS - 1 SP - 337 EP - 342 SN - 0022-1767 AD - Jankovic, D.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990806787. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 308067-58-5, 9008-11-1, 207137-56-2. Subject Subsets: Helminthology N2 - The function of the Th2 response in Schistosoma mansoni egg pathology was studied in interleukin (IL)-4Rα-deficient mice, which are nonresponsive to both IL-4 and IL-13. In striking contrast to IL-4 KO animals, infected IL-4Rα KO mice developed only minimal hepatic granulomas and fibrosis despite the presence of CD3+ T cells in the residual egg lesions. Liver lymphokine messenger RNA levels in these animals and IL-4 KO mice were equivalent. Infected IL-4Rα-deficient, IL-4-deficient and control mice developed similar egg antigen-specific IgG titres, arguing that CD4-dependent Th activity is intact in KO mice. As expected, IFN-γ secretion was strongly up-regulated in mesenteric lymph node cultures from both groups of deficient animals, a change reflected in increased serum IgG2a and IgG2b levels. Surprisingly, Th2 cytokine production in infected IL-4Rα KO mice was not abolished but was only reduced and resembled that previously documented in IL-4 KO animals. This residual Th2 response is likely to explain the ability of IL-4 KO mice to generate egg granulomas, which cannot be formed in IL-4Rα-deficient animals because of their lack of responsiveness to the same cytokine ligands. The results argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Rα+ non-T cell effector population. KW - experimental infections KW - fibrosis KW - granuloma KW - helminth ova KW - helminths KW - IgG KW - immune response KW - immunopathology KW - interferon KW - interleukin 4 KW - laboratory animals KW - liver KW - liver diseases KW - lymph nodes KW - mutants KW - parasites KW - T lymphocytes KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - parasitic worms KW - Strigeida KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990806787&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. AU - Hoffmann, K. F. AU - James, S. L. AU - Cheever, A. W. AU - Wynn, T. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 163 IS - 2 SP - 927 EP - 938 SN - 0022-1767 AD - Hoffmann, K. F.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990807116. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 130068-27-8, 207137-56-2. Subject Subsets: Helminthology N2 - The radiation-attenuated Schistosoma mansoni cercariae vaccine was used in mice genetically engineered to exhibit highly polarized type 1 (interleukin [IL]-10/IL-4-deficient) or type 2 (IL-10/IL-12-deficient) cytokine and antibody phenotypes. Significant differences in immunity were apparent after a single vaccination with irradiated cercariae in double cytokine-deficient versus wild-type mice but these differences disappeared after 2 vaccinations. Vaccinated IL-10-deficient mice developed a mixed and elevated type 1- and type 2-associated immune response and developed anti-schistosome immunity at levels equal to or better than those in wild-type mice. This immunity in IL-10-deficient mice correlated with higher parasite-specific antibody titres, greater proliferative capacity of lymphocytes, increased frequency of interferon (IFN)-γ- and IL-4-secreting cells, elevated perivascular/peribronchial inflammatory responses in the lung, and greater in vitro schistosomulacidal capacity of parasite antigen-elicited cells. The results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but to the induction of both type 1- and type 2-associated immune responses. KW - antibodies KW - cercariae KW - cytokines KW - deficiency KW - helminths KW - immune response KW - immunity KW - immunization KW - interleukin 10 KW - interleukin 12 KW - interleukin 4 KW - irradiated vaccines KW - laboratory animals KW - mutants KW - parasites KW - phenotypes KW - T lymphocytes KW - vaccines KW - mice KW - Schistosoma mansoni KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Schistosoma KW - Schistosomatidae KW - Digenea KW - Trematoda KW - Platyhelminthes KW - invertebrates KW - immune sensitization KW - immunity reactions KW - immunological reactions KW - parasitic worms KW - Strigeida KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807116&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. AU - Dent, A. L. AU - Doherty, T. M. AU - Paul, W. E. AU - Sher, A. AU - Staudt, L. M. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 163 IS - 4 SP - 2098 EP - 2103 SN - 0022-1767 AD - Dent, A. L.: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990807962. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 207137-56-2, 148157-34-0. Subject Subsets: Protozoology N2 - The BCL-6 gene negatively regulates Th2 responses in mice. BCL-6-/- mice on a Leishmania major-resistant genetic background (C57BL/6 × 129 intercrossed mice) were highly susceptible to L. major infection; they resembled BALB/c mice in terms of lesion size, parasite load, and the production of Th2 cytokines. BCL-6-/-IL (interleukin)-4-/- double-mutant mice were also susceptible to L. major infection, and produced levels of the Th2 cytokine IL-13 ten-fold higher than those produced by IL-4-/- littermate controls. By contrast, BCL-6-/-STAT6-/- double-mutant mice were resistant to L. major infection, despite also producing elevated levels of IL-13. It is concluded that STAT6 is required for susceptibility to L. major infection, and suggested that IL-13 signalling through STAT6 may contribute to a non-healing, exacerbated infection. KW - animal diseases KW - cytokines KW - experimental infections KW - human diseases KW - immune response KW - immunity KW - immunopathology KW - interleukin 13 KW - interleukin 4 KW - laboratory animals KW - leishmaniasis KW - parasites KW - susceptibility KW - Leishmania major KW - mice KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - immunity reactions KW - immunological reactions KW - immunopathogenesis KW - leishmaniosis KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15Rβ receptor. AU - Azimi, N. AU - Jacobson, S. AU - Leist, T. AU - Waldmann, T. A. JO - Journal of Immunology (Baltimore) JF - Journal of Immunology (Baltimore) Y1 - 1999/// VL - 163 IS - 7 SP - 4064 EP - 4072 SN - 0022-1767 AD - Azimi, N.: Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 20002006517. Publication Type: Journal Article. Language: English. Number of References: 55 ref. N2 - Human T lymphotropic virus type I (HTLV-I) is the causative agent of an inflammatory neurological disease termed HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). An ongoing lymphocyte activation exists in patients with HAM/TSP, which was demonstrated by the spontaneous proliferation of their PBMC ex vivo. It was shown that spontaneous proliferation present in HAM/TSP is due, in part, to an IL-2/IL-2R autocrine loop. However, addition of Abs against IL-2 or IL-2Rα only partially inhibited the spontaneous proliferation. Since IL-15 is a cytokine with similar functional characteristics to those of IL-2, it was reasoned that IL-15 might be an additional growth factor that contributes to the spontaneous proliferation observed in HAM/TSP. In this study, IL-15 mRNA expression was shown to be elevated in PBMC obtained from HAM/TSP patients when compared with those of the normal donors. Furthermore, it was shown that the addition of blocking Abs against IL-15 or its receptor inhibited the spontaneous proliferation of HAM/TSP PBMC. Addition of Abs directed toward both IL-15 and IL-2, or their receptors, inhibited the proliferation almost completely. These data suggest the existence of two autocrine loops involving IL-15/IL-15R and IL-2/IL-2R, both contributing to the spontaneous proliferation of HAM/TSP PBMC. KW - antibodies KW - cytokines KW - growth factors KW - human diseases KW - immunopathology KW - interleukins KW - lymphocyte transformation KW - myelopathy KW - pathogenesis KW - tropical spastic paraparesis KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - immunopathogenesis KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Human Immunology and Allergology (VV055) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Identification and characterization of novel variant major surface glycoprotein gene families in rat Pneumocystis carinii. AU - Huang, S. N. AU - Angus, C. W. AU - Turner, R. E. AU - Sorial, V. AU - Kovacs, J. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - 1 SP - 192 EP - 200 SN - 0022-1899 AD - Huang, S. N.: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19991200803. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Mycology N2 - Two novel variant major surface glycoprotein (vMSG) gene families in rat P. carinii that are closely related to but distinct from MSG were identified. These gene families encode proteins of ~90 kDa (v1MSG) and ~115 kDa (v2MSG). Compared with MSG, v1MSG is characterized by a deletion near the carboxyl terminus. The predicted v1MSG and v2MSG proteins are highly homologous to MSG at the carboxyl, but not the amino, terminus. Like MSG, they are cysteine-rich. Approx. 10% of the apparent molecular weight is due to N-linked glycosylation. Southern blotting studies demonstrated that, like MSG, v1MSG and v2MSG are the products of multicopy gene families. However, unlike MSG, each vMSG gene encodes a signal peptide, suggesting that the regulation of vMSG is different from that of MSG. KW - antigens KW - genes KW - major surface glycoproteins KW - molecular genetics KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - rats KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - antigenicity KW - biochemical genetics KW - fungus KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200803&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin. AU - Cooper, P. J. AU - Awadzi, K. AU - Ottesen, E. A. AU - Remick, D. AU - Nutman, T. B. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - 3 SP - 738 EP - 742 SN - 0022-1899 AD - Cooper, P. J.: Laboratory of Parasitic Diseases, NIAID, Bldg. 4, Room 126, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990804237. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 70288-86-7. Subject Subsets: Helminthology; Tropical Diseases N2 - To investigate the role of eosinophil activation and sequestration in the development and severity of adverse reactions after the treatment of Onchocerca volvulus infection, 40 O. volvulus-infected Ghanaians were randomized to receive a placebo, or ivermectin at a dose of 150, 400 or 600 mg/kg. Subjects were examined for typical physiologic and clinical events before and up to 48 h after treatment. Plasma samples were tested for interleukin (IL)-5 and eosinophil degranulation products (e.g., eosinophil-derived neurotoxin, EDN). After treatment, peripheral eosinophil counts declined in ivermectin-treated groups (P <.001), whereas circulating levels of IL-5 (P <.01) and EDN (P <.05) increased. Cumulative levels of IL-5 and EDN correlated with reaction scores (P <.01). High-dose ivermectin was associated with more severe reactions, more profound eosinopenia, and higher circulating levels of IL-5 and EDN, compared with the standard dose. These results suggest that eosinophil sequestration and activation/degranulation are associated with the initiation and severity of ivermectin-associated adverse reactions. KW - adverse effects KW - anthelmintics KW - blood plasma KW - drug therapy KW - eosinophils KW - helminths KW - human diseases KW - immunopathology KW - interleukin 5 KW - ivermectin KW - neurotoxins KW - onchocerciasis KW - parasites KW - placebos KW - Ghana KW - man KW - Onchocerca volvulus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Onchocerca KW - Onchocercidae KW - Rhabditida KW - Chromadoria KW - Chromadorea KW - Nematoda KW - invertebrates KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - Developing Countries KW - West Africa KW - Africa South of Sahara KW - adverse reactions KW - chemotherapy KW - eosinophil leukocytes KW - immunopathogenesis KW - nematodes KW - onchocercosis KW - parasitic worms KW - plasma (blood) KW - river blindness KW - Secernentea KW - Spirurida KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Physiology and Biochemistry (VV050) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804237&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. AU - Davey, R. T., Jr. AU - Chaitt, D. G. AU - Albert, J. M. AU - Piscitelli, S. C. AU - Kovacs, J. A. AU - Walker, R. E. AU - Falloon, J. AU - Polis, M. A. AU - Metcalf, J. A. AU - Masur, H. AU - Dewar, R. AU - Baseler, M. AU - Fyfe, G. AU - Giedlin, M. A. AU - Lane, H. C. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - 4 SP - 849 EP - 858 SN - 0022-1899 AD - Davey, R. T., Jr.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Room 11C103, Bethesda, MD 20892-1880, USA. N1 - Accession Number: 19992006359. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 102524-44-7, 85898-30-2. Subject Subsets: Public Health N2 - A total of 49 outpatients infected with human immunodeficiency virus with baseline CD4 cell counts ≥500/mm³, who were on stable antiretroviral therapy, were randomized to receive 5-day cycles of either low-dose (1.5 million IU [MIU] twice a day) or high-dose (7.5 MIU twice a day) subcutaneous (sc) interleukin (IL)-2 every 4 or 8 weeks. High-dose recipients experienced mean CD4 cell and percent slopes of +116.1 cells/month and +2.7%/month, respectively, whereas low-dose recipients displayed mean slopes of +26.7 and +1.3% in the same parameters. At month 6, high-dose recipients achieved a 94.8% increase in mean CD4 cells over baseline compared with a 19.0% increase in low-dose recipients. Although high-dose recipients encountered more constitutional side effects, these were generally not dose-limiting. It is concluded that high-dose scIL-2 therapy in outpatients with early HIV-1 infection was well tolerated and induced dramatic, sustained rises in CD4 cells. KW - CD4 antigens KW - cytokines KW - dosage KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunotherapy KW - interleukin 2 KW - T lymphocytes KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - CD4 KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - T cells KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006359&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus. AU - De Tan AU - Matsumoto, A. AU - Conry-Cantilena, C. AU - Melpolder, J. C. AU - Shih, J. W. K. AU - Leuther, M. AU - Hess, G. AU - Gibble, J. W. AU - Ness, P. M. AU - Alter, H. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - 5 SP - 1055 EP - 1061 SN - 0022-1899 AD - De Tan: Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992008728. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 63231-63-0. Subject Subsets: Public Health N2 - Serological, biochemical, and molecular analyses were used to study hepatitis G virus (HGV), antibody to the HGV envelope protein (anti-E2), risk factors, clinical significance, and the impact of HGV on coexistent hepatitis C virus (HCV). Among 329 donors in the USA with confirmed HCV infection, 12% were HGV RNA-positive and 44% were anti-E2-positive (total exposure, 56%). HGV RNA and anti-E2 were mutually exclusive except in 9 donors (1.5%); 8 of 9 subsequently lost HGV RNA but anti-E2 persisted. HGV had little impact on alanine aminotransferase, aspartate aminotransferase, or γ-glutamyl transpeptidase in donors with HGV infection alone or those co-infected with HCV. A multivariate analysis showed that injecting drug abuse was the leading risk factor for HGV transmission, followed by blood transfusion, snorting cocaine, imprisonment, and a history of sexually transmitted diseases. In summary, HGV and HCV infections were frequently associated and shared common parenteral risk factors; HGV did not appear to cause hepatitis or to worsen the course of coexistent hepatitis C. KW - blood donors KW - concurrent infections KW - human diseases KW - risk factors KW - RNA KW - USA KW - GB virus C KW - hepatitis C virus KW - hepatitis G virus KW - man KW - Flaviviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - Hepacivirus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - GB virus KW - ribonucleic acid KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008728&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Association of major histocompatibility complex determinants with the development of symptomatic and asymptomatic genital herpes simplex virus type 2 infections. AU - Lekstrom-Himes, J. A. AU - Hohman, P. AU - Warren, T. AU - Wald, A. AU - Nam JunMo AU - Simonis, T. AU - Corey, L. AU - Straus, S. E. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - 5 SP - 1077 EP - 1085 SN - 0022-1899 AD - Lekstrom-Himes, J. A.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, UK. N1 - Accession Number: 19992008731. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Public Health N2 - The clinical spectrum of herpes simplex virus (HSV) infections, ranging from asymptomatic to frequently distressing outbreaks, suggests that there may be immunological determinants of disease severity that are associated with human leukocyte antigen (HLA) expression. A controlled, prospective study identified several major histocompatibility complex (MHC) class I and II antigens whose frequencies are associated with HSV-2 infection or with frequent symptomatic genital recurrences. Previous studies were hampered by the inability to serologically identify patients with asymptomatic HSV-2 infection. Clinical evaluation and Western blot assay were used to identify 3 subject cohorts in the USA: 1 with no prior HSV infections, 1 with HSV-2 antibodies but no recognized symptoms, and 1 with HSV-2 antibodies and frequent genital recurrences. Statistical comparisons of HLA frequencies among these cohorts showed associations of HLA-B27 and -Cw2 with symptomatic disease. Also, HLA-Cw4 was significantly associated with HSV-2 infection. These associations indicate that immunological factors linked to the MHC influence the risk of HSV-2 infection and disease expression. KW - disease course KW - disease resistance KW - herpes simplex genitalis KW - human diseases KW - human leukocyte antigens KW - immunological factors KW - major histocompatibility complex KW - pathogenesis KW - symptoms KW - USA KW - Human herpesvirus 2 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Simplexvirus KW - Alphaherpesvirinae KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - disease progression KW - herpes simplex virus 2 KW - histocompatibility complex KW - resistance to disease KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008731&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - HIV infection, mucosal immunity and pathogenesis. A2 - Kresina, T. F. A2 - Mathieson, B. T2 - Journal of Infectious Diseases JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 179 IS - Suppl. 3 SP - S391 EP - S498 SN - 0022-1899 AD - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992009344. Publication Type: Conference proceedings. Language: English. KW - HIV infections KW - immunity KW - mucosa KW - pathogenesis KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mucous membrane KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009344&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection. AU - Hafner, R. AU - Inderlied, C. B. AU - Peterson, D. M. AU - Wright, D. J. AU - Standiford, H. C. AU - Drusano, G. AU - Muth, K. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 2 SP - 438 EP - 447 SN - 0022-1899 AD - Hafner, R.: Division of AIDS, National Institute of Allergy and Infectious Diseases, 6700-B Rockledge Dr. MSC 7624, Bethesda, MD 20892-7624, USA. N1 - Accession Number: 20002007148. Publication Type: Journal Article. Language: English. Number of References: 46 ref. N2 - The relationship between Mycobacterium avium complex (MAC) infection of blood and bone marrow was studied in human immunodeficiency virus-infected patients before and during treatment. Quantitative cultures were obtained at baseline from 17 persons with newly detected MAC bacteraemia. Serial blood cultures were obtained, and a second bone marrow sample was obtained at 4 or 8 weeks. At baseline, the median MAC load in bone marrow core samples was 3 log10 higher than in blood. Bone marrow MAC loads ranged widely (866-847 315 cfu/g), and no significant correlation was found between MAC load in blood and that in bone marrow core samples. MAC loads in bilateral bone marrow biopsy samples from 7 subjects were highly correlated. MAC loads declined in blood and bone marrow at similar rates during therapy, but blood was sterilized before bone marrow. Length of survival was inversely associated with initial bone marrow core MAC load but not with blood MAC load. Initiation of treatment when tissue MAC load is low may increase the likelihood of favourable clinical outcome. KW - acquired immune deficiency syndrome KW - bacteraemia KW - bone marrow KW - clinical aspects KW - disseminated infections KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - man KW - Mycobacterium KW - Mycobacterium avium KW - Mycobacterium avium complex KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - AIDS KW - bacteremia KW - bacterium KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Pesticides and Drugs; Control (HH405) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007148&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. AU - Lira, R. AU - Shyam Sundar AU - Makharia, A. AU - Kenney, R. AU - Gam, A. AU - Saraiva, E. AU - Sacks, D. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 2 SP - 564 EP - 567 SN - 0022-1899 AD - Lira, R.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19990807872. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7440-36-0, 12550-17-3. Subject Subsets: Protozoology N2 - The possibility that the high frequency of treatment failures in Indian kala azar might be due to infection with antimony-resistant strains of Leishmania donovani was experimentally addressed. L. donovani isolates were obtained from splenic aspiration smears of 24 patients in Bihar, India, who either did not respond (15) or did respond (9) to one or more full courses of treatment with sodium antimony gluconate (SAG). A strong correlation (P<0.001) between clinical response and SAG sensitivity in vitro was observed only when strains were assayed as intracellular amastigotes: responsive isolates ED50 = 2.4 ± 2.6 µg SAG/ml, ED90 = 6.4 ± 7.8 µg SAG/ml; unresponsive isolates ED50 = 7.4 ± 3.7 µg SAG/ml, ED90 = 29.1 ± 11.1 SAG/ml. No correlation with clinical response was found by use of extracellular promastigotes (ED50 = 48 ± 22 versus 52 ± 29 µg SAG/ml). The emergence of antimony-resistant L. donovani strains appears to be a cause of treatment failure in India. KW - amastigotes KW - antimony KW - antimony sodium gluconate KW - antiprotozoal agents KW - drug resistance KW - human diseases KW - in vitro KW - kala azar KW - leishmaniasis KW - parasites KW - promastigotes KW - spleen KW - strains KW - treatment failure KW - visceral leishmaniasis KW - Bihar KW - India KW - Leishmania donovani KW - man KW - protozoa KW - Leishmania KW - Trypanosomatidae KW - Kinetoplastida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - India KW - Commonwealth of Nations KW - Developing Countries KW - South Asia KW - Asia KW - antimonials KW - leishmaniosis KW - sodium antimony gluconate KW - Pesticide and Drug Resistance (HH410) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807872&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preliminary evaluation of human immunodeficiency virus type 1 (HIV-1) immunogen in children with HIV-1 infection. AU - Sei, S. AU - Sandelli, S. L. AU - Theofan, G. AU - Ratto-Kim, S. AU - Kumagai, M. AU - Loomis-Price, L. D. AU - Cox, J. H. AU - Jarosinski, P. AU - Walsek, C. M. AU - Brouwers, P. AU - Venzon, D. J. AU - Xu Jing AU - Pizzo, P. A. AU - Moss, R. B. AU - Robb, M. L. AU - Wood, L. V. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 3 SP - 626 EP - 640 SN - 0022-1899 AD - Sei, S.: HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19992012711. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Subject Subsets: Public Health N2 - The safety and preliminary activity of human immunodeficiency virus type 1 (HIV-1) immunogen were evaluated [date not given] in 10 HIV-1-infected children with disease stage N1,2 or A1,2 in the USA . Multiple inoculations of 2.5 or 10 units (U) of HIV-1 immunogen were safe and well tolerated without an acceleration of disease progression. When antiretroviral agents were coadministered, the 10 U dose appeared to be associated with more sustained reduction in plasma HIV-1 RNA than the 2.5 U dose (median log10 HIV-1 RNA at month 18, 3.07 vs. 4.01 copies/ml in 10 U (n=4) vs. 2.5 U (n=3), respectively; P=0.034). Levels of regulated-on-activation, normal T cell-expressed and -secreted chemokine produced from HIV-1 immunogen-stimulated lymphocytes in vitro were increased in the children who had HIV-1 immunogen-specific antibody responses (P<0.02) and appeared to be inversely correlated with levels of plasma HIV-1 RNA (P<0.01). It is suggested that these preliminary data warrant larger studies to determine the effectiveness of adjunctive therapy with HIV-1 immunogen in children with HIV-1 infection. KW - antigens KW - chemokines KW - children KW - clinical aspects KW - drug therapy KW - HIV infections KW - human diseases KW - immune response KW - immunotherapy KW - lymphocytes KW - safety KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - antigenicity KW - chemotherapy KW - clinical picture KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - immunity reactions KW - immunogenicity KW - immunogens KW - immunological reactions KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012711&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HTLV-I/II seroindeterminate western blot reactivity in a cohort of patients with neurological disease. AU - Soldan, S. S. AU - Graf, M. D. AU - Waziri, A. AU - Flerlage, A. N. AU - Robinson, S. M. AU - Kawanishi, T. AU - Leist, T. P. AU - Lehky, T. J. AU - Levin, M. C. AU - Jacobson, S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 3 SP - 685 EP - 694 SN - 0022-1899 AD - Soldan, S. S.: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 5B-16, Bethesda, MD 10892, USA. N1 - Accession Number: 19992012716. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health N2 - Eight patients with neurological disease and an human T-cell lymphotropic virus type I/II (HTLV-I/II) seroindeterminate Western blot pattern were identified in Japan and the USA, none of whom demonstrated increased spontaneous proliferation and HTLV-I-specific cytotoxic T lymphocyte activity. However, HTLV-I tax sequence was amplified from the peripheral blood lymphocytes of 4 of them. It is suggested that patients with chronic progressive neurological disease and HTLV-I/II Western blot seroindeterminate reactivity may harbour either defective HTLV-I, novel retrovirus with partial homology to HTLV-I, or HTLV-I in low copy number. KW - clinical aspects KW - diagnosis KW - HTLV-I infections KW - human diseases KW - nervous system diseases KW - screening KW - T lymphocytes KW - tropical spastic paraparesis KW - Japan KW - USA KW - Deltaretrovirus KW - human T-cell lymphotropic virus type I KW - human T-cell lymphotropic virus type II KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - East Asia KW - Asia KW - OECD Countries KW - North America KW - America KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - clinical picture KW - HTLV-BLV group KW - neuropathy KW - screening tests KW - T cells KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012716&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for human T cell lymphotropic virus type II infection among the Guaymi Indians of Panama. AU - Maloney, E. M. AU - Armien, B. AU - Gracia, F. AU - Castillo, L. AU - Kruger, H. AU - Levin, A. AU - Levine, P. H. AU - Kaplan, J. E. AU - Blattner, W. A. AU - Giusti, R. M. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 3 SP - 876 EP - 879 SN - 0022-1899 AD - Maloney, E. M.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza N., Room 434, 6130 Executive Blvd., MSC 7399, Bethesda, MD 20892-7399, USA. N1 - Accession Number: 19992012730. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Tropical Diseases N2 - A case-control study was conducted among the Guaymi Indians of Panama to examine risk factors for human T cell lymphotropic virus type II (HTLV-II) infection. 198 of 334 seropositive Guaymi ≥12 years of age, residing on 10 banana plantations in and around Changuinola, Bocas del Toro Province, and 460 matched seronegative controls, were enrolled between August 1994 and June 1996. In females, HTLV-II seropositivity was associated with early sexual intercourse (≤13 vs.>15 years; odds ratio (OR), 2.50; 95% confidence interval (CI), 1.11-6.14) and number of lifetime sex partners. One partner increased risk of seropositivity by 30% (OR, 1.30; CI, 1.05-1.64), and risk increased with number of partners. Similar risk was associated with number of long-term sexual relationships. Among males, intercourse with prostitutes was associated with HTLV-II seropositivity (OR, 1.68; CI, 1.04-2.72). These data support a role for sexual transmission in HTLV-II infection. It is suggested that association of seropositivity with primary residence in a traditional village (OR, 3.75; CI, 1.02-15.38) and lack of formal education (0 vs. >6 years (OR, 3.89; CI, 1.67-9.82)) observed in males may reflect differences in sexual practices associated with acculturation. KW - disease transmission KW - education KW - ethnic groups KW - human diseases KW - males KW - prostitutes KW - prostitution KW - risk factors KW - sex differences KW - sexual behaviour KW - sexual intercourse KW - sexual partners KW - sexual transmission KW - villages KW - Panama KW - Deltaretrovirus KW - human T-cell lymphotropic virus type II KW - man KW - Human T-cell lymphotropic virus KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Central America KW - America KW - Developing Countries KW - Latin America KW - Threshold Countries KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - HTLV-BLV group KW - sexual behavior KW - sexual practices KW - sexuality KW - venereal transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Social Psychology and Culture (UU490) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012730&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma. AU - O'Brien, T. R. AU - Kedes, D. AU - Ganem, D. AU - Macrae, D. R. AU - Rosenberg, P. S. AU - Molden, J. AU - Goedert, J. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 4 SP - 1010 EP - 1017 SN - 0022-1899 AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8016, Rockville, MD 20852, USA. N1 - Accession Number: 20002008396. Publication Type: Journal Article. Language: English. Number of References: 36 ref. N2 - Human herpesvirus 8 (HHV-8) seroprevalence and seroincidence was examined among 245 homosexual men from New York City (NYC) and Washington, DC (DC), USA, who have been followed since 1982. An immunofluorescence assay measured antibodies to a latent HHV-8 nuclear antigen. Seroprevalence was 20.4% in 1982; seroincidence was ~15%/year during 1982-1983 but fell sharply thereafter. NYC men had a higher seroprevalence (odds ratio, 3.43; P<0.001) and seroincidence (rate ratio, 2.13; P=0.01) than DC men. Risk of Kaposi's sarcoma (KS) was increased in seropositive men (adjusted relative hazard, 3.58; P=0.02). Among men who were seropositive for both human immunodeficiency virus type 1 and HHV-8, the 10-year cumulative risk of KS was 39%; time from coinfection to KS diagnosis ranged from 15 to 154 months (median, 63.5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS. KW - antibodies KW - concurrent infections KW - epidemics KW - epidemiology KW - HIV-1 infections KW - homosexuality KW - human diseases KW - incidence KW - Kaposi's sarcoma KW - men KW - risk factors KW - seroprevalence KW - District of Columbia KW - New York KW - USA KW - Herpesviridae KW - human herpesvirus 8 KW - Human immunodeficiency virus 1 KW - man KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Herpesviridae KW - Rhadinovirus KW - Gammaherpesvirinae KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - Middle Atlantic States of USA KW - Northeastern States of USA KW - homosexuals KW - human immunodeficiency virus type 1 KW - United States of America KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002008396&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. AU - Engels, E. A. AU - Rosenberg, P. S. AU - Biggar, R. J. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 6 SP - 1784 EP - 1789 SN - 0022-1899 AD - Engels, E. A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., MSC 7248, Rockville, MD 20822, USA. N1 - Accession Number: 20002009218. Publication Type: Journal Article. Corporate Author: USA, District of Columbia Gay Cohort; Multicenter Hemophilia Cohort Study Language: English. Number of References: 29 ref. Subject Subsets: Public Health N2 - Risk factors for zoster and trends in incidence in human immunodeficiency virus (HIV)-infected haemophiliacs and homosexual men from the USA and Europe (n=1218) were examined. 174 zoster cases were identified between 1984 and 1997 (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk (RR), 4.30; 95% confidence interval (CI), 3.11-5.95). Among haemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts were >200 cells/mm³, but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or aciclovir use. KW - adolescents KW - children KW - haemophilia KW - herpes zoster KW - HIV infections KW - homosexuality KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - incidence KW - leukocyte count KW - men KW - opportunistic infections KW - risk factors KW - shingles KW - Europe KW - USA KW - Human herpesvirus 3 KW - man KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - Varicellovirus KW - Alphaherpesvirinae KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cell count KW - hemophilia KW - homosexuals KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - teenagers KW - United States of America KW - varicella-zoster virus KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Host Resistance and Immunity (HH600) KW - Human Immunology and Allergology (VV055) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009218&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Virus levels in untreated African infants infected with human immunodeficiency virus type 1. AU - Biggar, R. J. AU - Janes, M. AU - Pilon, R. AU - Miotti, P. AU - Taha, T. E. T. AU - Broadhead, R. AU - Mtimivalye, L. AU - Kumwenda, N. AU - Cassol, S. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 6 SP - 1838 EP - 1843 SN - 0022-1899 AD - Biggar, R. J.: Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 20002009224. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Tropical Diseases N2 - Human immunodeficiency virus levels were assessed during 1994-97 in untreated infants in Malawi by analysis of dried blood spots tested by nucleic acid silica-bound amplification. Of 24 umbilical cord blood (CB)-positive samples, 83% had >10 000 copies/ml. The median virus level was 78 000 copies/ml. First positive sample median levels were 355 000 copies/ml among 52 perinatally infected infants and 130 000 copies/ml among 43 infants infected by breast-feeding. Virus levels were stable and initial levels predicted levels one year after infection (P=0.005), at which time levels did not significantly differ among in utero, perinatally, or postnatally infected infants. Neither age at infection nor route of infection significantly influenced HIV levels measured one year after infection. Most (87%) CB-positive infants were infected before labour onset, since virus levels greatly exceeded those expected in their mothers. KW - HIV infections KW - HIV-1 infections KW - human diseases KW - infants KW - maternal transmission KW - mothers KW - viral load KW - women KW - Malawi KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - ACP Countries KW - Anglophone Africa KW - Africa KW - Commonwealth of Nations KW - East Africa KW - Africa South of Sahara KW - Least Developed Countries KW - Developing Countries KW - SADC Countries KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - Nyasaland KW - Human Reproduction and Development (VV060) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009224&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. AU - Ma LiAng AU - Borio, L. AU - Masur, H. AU - Kovacs, J. A. JO - Journal of Infectious Diseases JF - Journal of Infectious Diseases Y1 - 1999/// VL - 180 IS - 6 SP - 1969 EP - 1978 SN - 0022-1899 AD - Ma LiAng: Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892-1662, USA. N1 - Accession Number: 20001202187. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 80-08-0, 9002-03-3, 723-46-6, 738-70-5. Subject Subsets: Medical & Veterinary Mycology N2 - To explore whether P. carinii is developing resistance to trimethoprim (TMP), the human P. carinii dihydrofolate reductase (DHFR) gene was cloned. DHFR and dihydropteroate synthase (DHPS) genes in 37 P. carinii isolates, obtained from 35 patients in Maryland, USA, between 1985 and 1998, were sequenced. The relationship between TMP-sulfamethoxazole or dapsone use and gene mutations was analysed. The DHFR gene sequences were identical in all isolates except one with a synonymous substitution. In contrast, the DHPS gene sequences showed mutations in 16 of the 37 isolates; prior sulfa/sulfone prophylaxis was associated with the presence of these mutations (P<0.001). It is concluded that, in addition to suggesting that there is less selective pressure on DHFR than on DHPS, this study reinforces the hypothesis that mutations in the DHPS genes are involved in the development of sulfa-resistance in P. carinii. Nucleotide sequences reported were submitted to the GenBank databases under Accession Numbers AF090368 and AF139132. KW - dapsone KW - dihydrofolate reductase KW - drug resistance KW - genes KW - human diseases KW - mutations KW - nucleotide sequences KW - sulfamethoxazole KW - trimethoprim KW - Maryland KW - USA KW - man KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystis carinii KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Pneumocystis KW - Pneumocystidaceae KW - Pneumocystidales KW - Pneumocystidomycetes KW - Taphrinomycotina KW - Ascomycota KW - fungi KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - dihydropteroate synthase KW - DNA sequences KW - fungus KW - sulphamethoxazole KW - tetrahydrofolate dehydrogenase KW - United States of America KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Pesticide and Drug Resistance (HH410) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202187&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Isolation, characterization, and localization of a capsule-associated gene, CAP10, of Cryptococcus neoformans. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1999/// VL - 181 IS - 18 SP - 5636 EP - 5643 SN - 0021-9193 AD - Chang, Y. C.: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20001203767. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Mycology N2 - The isolation and characterization of a novel gene, CAP10, which is required for C. neoformans capsule formation, is described. Complementation of the acapsular cap10 mutant produced an encapsulated strain and the deletion of CAP10 from a wild strain resulted in an acapsular phenotype. The molecular mass of the haemagglutinin epitope-tagged Cap10p is about 73 kDa, which is similar to the size predicted from sequence analysis. When CAP10 was fused with a hybrid green fluorescent protein construct, the fluorescence signals appeared as patches in the cytoplasm. Using a reporter gene construct, it was found that CAP10 was expressed at high levels in late-stationary-phase cells. In addition, the expression levels of CAP10 were modulated by the transcriptional factor STE12α. Deletion of STE12α downregulated the expression levels of CAP10 while overexpression of STE12α upregulated the expression levels of CAP10. Animal model studies in mice indicated that deletion of the CAP10 gene resulted in the loss of virulence, and complementation of the acapsular phenotype of cap10 restored virulence. Thus, CAP10 is required for capsule formation and virulence. KW - cryptococcosis KW - experimental infections KW - genes KW - laboratory animals KW - molecular genetics KW - morphology KW - pathogenicity KW - phenotypes KW - virulence KW - Cryptococcus neoformans KW - mice KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - fungi KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - biochemical genetics KW - capsule KW - european blastomycosis KW - fungus KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) KW - Animal Models of Human Diseases (VV400) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001203767&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus. AU - Tsai HueiFung AU - Wheeler, M. H. AU - Chang, Y. C. AU - Kwon-Chung, K. J. JO - Journal of Bacteriology JF - Journal of Bacteriology Y1 - 1999/// VL - 181 IS - 20 SP - 6469 EP - 6477 SN - 0021-9193 AD - Tsai HueiFung: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, 10 Center Dr., MSC 1882, Bethesda, MD 20892-1882, USA. N1 - Accession Number: 20001202907. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology N2 - Six genes, forming a gene cluster spanning 19 kb, were identified as involved in conidial pigment biosynthesis in A. fumigatus. Northern blot analyses showed the 6 genes to be developmentally regulated and expressed during conidiation. The gene products of alb1 (for "albino 1"), arp1 (for "aspergillus reddish-pink 1") and arp2 have high similarity to polyketide synthases, scytalone dehydratases and hydroxynaphthalene reductases, respectively, found in the dihydroxynaphthalene (DHN)-melanin pathway of brown and black fungi. The abr1 gene (for "aspergillus brown 1") encodes a putative protein possessing 2 signatures of multicopper oxidases. The abr2 gene product has homology to the laccase encoded by the yA gene of A. nidulans. The function of ayg1 (for "aspergillus yellowish-green 1") remains unknown. Involvement of the 6 genes in conidial pigmentation was confirmed by the altered conidial colour phenotypes that resulted from disruption of each gene in A. fumigatus. The presence of a DHN-melanin pathway in A. fumigatus was supported by the accumulation of scytalone and flaviolin in the arp1 deletant, whereas only flaviolin was accumulated in the arp2 deletants. Scytalone and flaviolin are well-known signature metabolites of the DHN-melanin pathway. Based on DNA sequence similarity, gene disruption results, and biochemical analyses, it is concluded that the 19-kb DNA fragment contains a 6-gene cluster which is required for conidial pigment biosynthesis in A. fumigatus. However, the presence of abr1, abr2, and ayg1 in addition to alb1, arp1, and arp2 suggests that conidial pigment biosynthesis in A. fumigatus is more complex than the known DHN-melanin pathway. KW - biosynthesis KW - DNA KW - genes KW - genetics KW - metabolites KW - nucleotide sequences KW - pathogenicity KW - phenotypes KW - physiology KW - pigmentation KW - pigments KW - Aspergillus KW - Aspergillus fumigatus KW - Emericella nidulans KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Aspergillus KW - Emericella KW - Aspergillus nidulans KW - deoxyribonucleic acid KW - DNA sequences KW - fungus KW - Hyphomycetes KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202907&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-γ- and tumor necrosis factor (TNF)-α-dependent host resistance to the intracellular pathogen, Toxoplasma gondii. AU - Yap, G. S. AU - Sher, A. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1999/// VL - 189 IS - 7 SP - 1083 EP - 1091 SN - 0022-1007 AD - Yap, G. S.: Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990804394. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 9008-11-1, 10102-43-9, 308079-78-9. Subject Subsets: Protozoology N2 - Pathogens within non-haemopoietic cells may be killed by metabolites secreted by activated macrophages or, alternatively, directly controlled by cytokine-induced microbicidal mechanisms triggered within infected non-phagocytic cells. To distinguish between these 2 basic mechanisms of cell mediated immunity, reciprocal bone marrow chimaeras were constructed between wild-type and interferon (IFN)-γ receptor-deficient mice and their survival was assessed following infection with Toxoplasma gondii, which invades both haemopoietic and non-haemopoietic cell lineages. Resistance to acute and persistent infection was displayed only by animals in which INF-γ receptors were expressed in both cellular compartments. Parallel chimaera experiments performed with tumour necrosis factor (TNF) receptor-deficient mice also indicated a co-dependence on haemopoietic and non-haemopoietic lineages for optimal control of the parasite. In contrast, in mice chimaeric for inducible nitric oxide synthase (iNOS), an enzyme associated with IFN-γ-induced macrophage microbicidal activity, expression by cells of haemopoietic origin was sufficient for host resistance. The results suggest that, in concert with bone marrow-derived effectors, non-haemopoietic cells can directly mediate, in the absence of endogenous iNOS, IFN-γ- and TNF-α-dependent host resistance to intracellular infection. KW - bone marrow KW - cell mediated immunity KW - cells KW - cytokines KW - deficiency KW - disease resistance KW - enzymes KW - experimental infections KW - haematopoiesis KW - immune response KW - interferon KW - laboratory animals KW - macrophages KW - metabolites KW - mutants KW - nitric oxide KW - parasites KW - receptors KW - tumour necrosis factor KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - blood formation KW - cachectin KW - cachexin KW - cellular immunity KW - haemopoiesis KW - hematopoiesis KW - immunity reactions KW - immunological reactions KW - nitric oxide synthase KW - resistance to disease KW - tumor necrosis factor KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. AU - Tonnetti, L. AU - Verí, M. C. AU - Bonvini, E. AU - D'Adamio, L. JO - Journal of Experimental Medicine JF - Journal of Experimental Medicine Y1 - 1999/// VL - 189 IS - 10 SP - 1581 EP - 1589 SN - 0022-1007 AD - Tonnetti, L.: T-Cell Apoptosis Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19991201952. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 9026-43-1. N2 - Studying apoptosis induced by T cell receptor (TCR) cross-linking in the T cell hybridoma, 3DO, both neutral sphingomyelinase activation and production of ceramide was found upon receptor engagement. Pharmacological inhibition of ceramide production by fumonisin B1 impaired TCR-induced interleukin (IL)-2 production and programmed cell death. Addition of either exogenous ceramide or bacterial sphingomyelinase reconstituted both responses. Moreover, specific inactivation of neutral sphingomyelinase by antisense RNA inhibited IL-2 production and mitogen-activated protein kinase activation after TCR triggering. It is suggested that ceramide production by activation of neutral sphingomyelinase is an essential component of the TCR signalling machinery. KW - apoptosis KW - fumonisins KW - protein kinase KW - T lymphocytes KW - toxicity KW - ceramide KW - T cells KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201952&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Plasmodium gallinaceum ookinetes adhere specifically to the midgut epithelium of Aedes aegypti by interaction with a carbohydrate ligand. AU - Zieler, H. AU - Nawrocki, J. P. AU - Shahabuddin, M. JO - Journal of Experimental Biology JF - Journal of Experimental Biology Y1 - 1999/// VL - 202 IS - 5 SP - 485 EP - 495 SN - 0022-0949 AD - Zieler, H.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990503696. Publication Type: Journal Article. Language: English. Number of References: 76 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology N2 - During the course of its development in Culicidae and transmission to a new vertebrate host, Plasmodium must interact with the mosquito midgut and invade the gut epithelium. To investigate how the parasite recognizes the midgut before invasion, an in vitro adhesion assay based on combining fluorescently labelled ookinetes with isolated midgut epithelia from blood-fed mosquitoes was developed. Using this assay, it was found that P. gallinaceum ookinetes readily adhered to midguts of A. aegypti, mimicking the natural recognition of the epithelium by the parasite. This interaction is specific: the ookinetes preferentially adhered to the lumen (microvillar) side of the gut epithelium and did not bind to other mosquito tissues. Conversely, the binding was not due to a non-specific adhesive property of the midguts, because a variety of other cell types, including untransformed P. gallinaceum zygotes or macrogametes, did not show similar binding to the midguts. High concentrations of glycosylated (fetuin, orosomucoid, ovalbumin) or non-glycosylated (bovine serum albumin) proteins, added as non-specific competitors, failed to compete with the ookinetes in binding assays. It was also found that the adhesion of ookinetes to the midgut surface is necessary for sporogonic development of the parasite in the mosquito. Antibodies and other reagents that blocked adhesion in vitro also reduced oocyst formation when these reagents were combined with mature ookinetes and fed to mosquitoes. Chemical modification of the midguts with sodium periodate at pH 5.5 destroyed adhesion, indicating that the ookinete binds to a carbohydrate ligand on the surface of the midgut. The ligand is sensitive to periodate concentrations of <1 mmol litre-1, suggesting that it may contain sialic-acid-like sugars. Furthermore, free N-acetylneuraminic acid competed with the ookinetes in binding assays, while other monosaccharides had no effect. However, in agreement with the current belief that adult insects do not contain sialic acids, no sialic acids were detected in mosquito midguts using the most sensitive HPLC-based fluorometric assay currently available. It is postulated that a specific carbohydrate group is used by the ookinete to recognize the midgut epithelium and to attach to its surface. This is the 1st receptor-ligand interaction demonstrated for the ookinete stage of a malaria parasite. Further characterization of the midgut ligand and its parasite counterpart may lead to novel strategies of blocking oocyst development in the mosquito. KW - adhesion KW - albumins KW - antibodies KW - binding KW - biochemistry KW - epithelium KW - host parasite relationships KW - intestines KW - ligands KW - malaria KW - midgut KW - oocysts KW - ookinetes KW - parasites KW - proteins KW - sialic acids KW - Aedes aegypti KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503696&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Purification and cloning of the salivary peroxidase/catechol oxidase of the mosquito Anopheles albimanus. AU - Ribeiro, J. M. C. AU - Valenzuela, J. G. JO - Journal of Experimental Biology JF - Journal of Experimental Biology Y1 - 1999/// VL - 202 IS - 7 SP - 809 EP - 816 SN - 0022-0949 AD - Ribeiro, J. M. C.: Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, 4 Center Drive MSC-0425, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990503606. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 903-99-0. N2 - Salivary homogenates of the adult female mosquito Anopheles albimanus have been shown previously to contain a vasodilatory activity associated with a catechol oxidase/peroxidase activity. A study was carried out in which the salivary peroxidase was purified using high-performance liquid chromatography. The pure enzyme was able to relax rabbit aortic rings pre-constricted with norepinephrine. The peroxidase had a relative molecular mass of 66 907 as estimated by mass spectrometry. Oligonucleotide probes for isolation of cDNA clones derived from the salivary gland mRNA from female mosquitoes were designed using amino-terminal sequencing. The full sequence of the cDNA demonstrated homology between A. albimanus salivary peroxidase and several members of the myeloperoxidase gene family. A close comparison of A. albimanus salivary peroxidase with canine myeloperoxidase, for which the crystal structure is known, showed that all six disulfide bridges were conserved and demonstrated identity for all five residues associated with a Ca2+-binding site. In addition, 16 of 26 residues shown to be in close proximity to the haeme moiety in the canine myeloperoxidase were identical. It is concluded that the salivary peroxidase of A. albimanus belongs to the myeloperoxidase gene family. Other possible functions for this molecule in blood feeding are discussed. KW - clones KW - complementary DNA KW - messenger RNA KW - peroxidase KW - residues KW - salivary glands KW - Anopheles KW - Anopheles albimanus KW - Culicidae KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - cDNA KW - cloning KW - mosquitoes KW - mRNA KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503606&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Salivary glands of the sand fly Phlebotomus papatasi contain pharmacologically active amounts of adenosine and 5′-AMP. AU - Ribeiro, J. M. C. AU - Katz, O. AU - Pannell, L. K. AU - Waitumbi, J. AU - Warburg, A. JO - Journal of Experimental Biology JF - Journal of Experimental Biology Y1 - 1999/// VL - 202 IS - 11 SP - 1551 EP - 1559 SN - 0022-0949 AD - Ribeiro, J. M. C.: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Building 4, Room 126, 4 Center Drive MSC-0425, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990504819. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 58-61-7, 61-19-8. Subject Subsets: Medical & Veterinary Entomology N2 - Salivary gland homogenates of P. papatasi contain large amounts of adenosine and 5′-AMP, of the order of 1 nmol per pair of glands, as demonstrated by liquid chromatography, ultraviolet spectrometry, mass spectrometry and bioassays. These purines, 75-80% of which are secreted from the glands following a blood meal, have vasodilatory and anti-platelet activities and probably help the fly to obtain a blood meal. Salivary 5′-AMP is also responsible for the previously reported protein phosphatase inhibitor in the salivary glands of P. papatasi, which is shown to be artefactual in nature as a result of allosteric modification by AMP of the phosphatase substrate used (phosphorylase a). KW - adenosine KW - AMP KW - biochemistry KW - blood meal KW - saliva KW - salivary glands KW - Diptera KW - Phlebotominae KW - Phlebotomus papatasi KW - Psychodidae KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Psychodidae KW - Diptera KW - Phlebotomus KW - Phlebotominae KW - adenosine monophosphate KW - salivary secretions KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Preclinical efficacy studies of green and black tea extracts (44367). AU - Steele, V. E. AU - Bagheri, D. AU - Balentine, D. A. AU - Boone, C. W. AU - Rajendra Mehta AU - Morse, M. A. AU - Sheela Sharma AU - Sigman, C. C. AU - Stoner, G. D. AU - Wargovich, M. J. AU - Weisburger, J. H. AU - Zhu SongYun AU - Kelloff, G. J. A2 - Weisburger, J. H. JO - Proceedings of the Society for Experimental Biology and Medicine JF - Proceedings of the Society for Experimental Biology and Medicine Y1 - 1999/// VL - 220 IS - 4 SP - 210 EP - 212 SN - 0037-9727 AD - Steele, V. E.: National Cancer Institute (NCI), Chemoprevention Branch, 9000 Rockville Pike, Executive Plaza North, Suite 201, Bethesda, MD 20892-7322, USA. N1 - Accession Number: 19991407478. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 5 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition N2 - Results are presented from in vitro mechanistic and cell transformation assays screening for the cancer chemopreventive efficacy of flavanol compounds of tea. KW - antioxidants KW - DNA KW - drug therapy KW - flavanols KW - free radicals KW - in vitro KW - neoplasms KW - phenolic compounds KW - tea KW - Camellia sinensis KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - cancers KW - chemotherapy KW - deoxyribonucleic acid KW - epigallocatechin gallate KW - Crop Produce (QQ050) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407478&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Polyethylene glycol-mediated infection of non-permissive mammalian cells with Semliki Forest virus: application to signal transduction studies. AU - Ramachandran Arudchandran AU - Brown, M. J. AU - Song, J. S. AU - Wank, S. A. AU - Haleem-Smith, H. AU - Rivera, J. JO - Journal of Immunological Methods JF - Journal of Immunological Methods Y1 - 1999/// VL - 222 IS - 1/2 SP - 197 EP - 208 SN - 0022-1759 AD - Ramachandran Arudchandran: Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 19990502661. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 37341-29-0, 308067-57-4, 25322-68-3, 9026-43-1, 60-18-4. N2 - Semliki Forest virus (SFV) vectors allow the subcloning of a gene of interest directly in the expression vector, thus avoiding the need to select and purify viral recombinants, making this viral expression system attractive over many others for mammalian protein expression. A novel and generally applicable method for infection of non-permissive mammalian cells with SFV is described, that greatly enhances the utility of this expression system. It was demonstrated that the hygroscopic polymer poly (ethylene glycol), PEG, promotes the infectivity of cells by SFV under conditions that did not promote cell-cell fusion. It was also found that the PEG-induced infection and expression of an exogenous protein (green fluorescent protein, GFP) did not elevate the basal tyrosine kinase activity, induce a stress-activated responses, or result in aberrant cell responses. Expression of GFP tagged-Vav, an activator of stress-activated protein kinase (SAPK/JNK), resulted in the expected induction of JNK activity and in the normal redistribution of Vav in response to engagement of the high affinity receptor for IgE (FcεRI). Thus, the findings that PEG allows the infection of non-permissive cells by SFV makes this system extremely attractive for expression of proteins in mammalian cells, and studies on signal transduction and cellular localization in immune and non-immune cells. KW - arboviruses KW - cells KW - IgE KW - immunoglobulins KW - infectivity KW - kinases KW - localization KW - polyethylene glycol KW - protein kinase KW - proteins KW - transduction KW - tyrosine KW - vectors KW - Semliki Forest virus KW - Alphavirus KW - Togaviridae KW - positive-sense ssRNA viruses KW - ssRNA viruses KW - RNA viruses KW - viruses KW - arthropod-borne viruses KW - gamma-globulins KW - immune globulins KW - polyoxyethylene KW - reagin KW - reaginic antibodies KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502661&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cytokine and immunoglobulin concentrations in cervical secretions: reproducibility of the Weck-cel collection instrument and correlates of immune measures. AU - Hildesheim, A. AU - McShane, L. M. AU - Schiffman, M. AU - Bratti, M. C. AU - Rodriguez, A. C. AU - Herrero, R. AU - Morera, L. A. AU - Cardenas, F. AU - Saxon, L. AU - Bowman, F. P. AU - Crowley-Nowick, P. A. JO - Journal of Immunological Methods JF - Journal of Immunological Methods Y1 - 1999/// VL - 225 IS - 1/2 SP - 131 EP - 143 SN - 0022-1759 AD - Hildesheim, A.: Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, 6130 Executive Blvd, EPN 443, Bethesda, MD 20892-7374, USA. N1 - Accession Number: 19992009450. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 308067-58-5, 308067-57-4. N2 - The reproducibility of the Weck-cel sponge used to collect cervical secretions for immunological assessment was assessed. Correlates of immunity were also examined as part of the investigation. Two cervical secretion specimens were collected sequentially from each of 120 women using Weck-cel sponges. Cervical secretions were collected prior to Pap smear sampling to avoid blood contamination. At the laboratory, the duplicate specimens were weighed and tested in replicate wells to determine the concentration of 2 cytokines (IL-10 and IL-12) and 2 immunoglobulin isotypes (IgG and IgA). IL-12, total IgG, and total IgA showed a strong correlation between samples from the same woman ranging from 0.78 to 0.84. Kappa coefficients obtained after categorising assay results ranged from 0.62 to 0.67. Variance components analysis suggested that 69% to 85% of the variance observed was accounted for by between-women variance, with the remaining variability attributed to variation between samples collected from the same woman. IL-10 results were less reproducible than those obtained from the other assays examined, suggesting problems with the assay used to measure this cytokine rather than with the Weck-cel sampling instrument. Various factors were found to significantly correlate with cytokine and immunoglobulin measures at the cervix. Age and reproductive status were associated with all 4 immune measures; women over 50 years of age and those who were postmenopausal had increased concentrations of IL-10, IL-12, IgG, and IgA. Haemoglobin concentrations were positively correlated with IgG and IL-10 concentrations, but not with IgA or IL-12 concentrations, suggesting local production of IgA and IL-12. The concentration of all immune measures decreased with increasing volume of collection. No significant association was observed between time from collection to freezing of specimens and concentrations of cytokines or immunoglobulins. Overall, the data suggest that measurement of immunological parameters in cervical secretions collected using Weck-cel sponges are reproducible. In addition, various correlates of cytokine and immunoglobulin concentrations were identified. KW - cervix KW - cytokines KW - IgA KW - IgG KW - immunoglobulins KW - methodology KW - sampling KW - secretions KW - techniques KW - women KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - gamma-globulins KW - immune globulins KW - methods KW - sampling techniques KW - Host Resistance and Immunity (HH600) KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009450&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Characterization of the glyceraldehyde-3-phosphate gene and the use of its promoter for heterologous expression in Cryptococcus neoformans, a human pathogen. AU - Varma, A. AU - Kwon-Chung, K. J. JO - Gene JF - Gene Y1 - 1999/// VL - 232 IS - 2 SP - 155 EP - 163 SN - 0378-1119 AD - Varma, A.: Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20001202106. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9007-49-2, 37250-87-6, 9001-50-7, 9028-92-6. Subject Subsets: Medical & Veterinary Mycology N2 - The GPD gene encoding glyceraldehyde-3-phosphate dehydrogenase was isolated from C. neoformans. The gene contained 11 introns, differing from the conserved intron positions found in the GPD genes of Basidiomycetes. The predicted amino-acid sequence of this gene was very similar to that reported from GPD proteins of other Basidiomycetes. The promoter region of the C. neoformans GPD gene was similar to those of other Basidiomycetes. Plasmid constructs containing up to 1600 base pairs upstream of the native GPD open reading frame were used to express either the native URA5 gene in a ura5 mutant or the heterologous hphI gene (a bacterial gene that confers resistance to the aminoglycoside hygromycin) in a wild-type strain of C. neoformans. Transformation frequencies resulting from the plasmid-borne Gpdp::URA5 gene were at levels similar to those of the native URA5, which suggested that all the sequences necessary for proper expression were present. Transformation frequencies using the Gpdp::hphI gene constructs were poor. However, addition of DNA sequences flanking the 3′-end of an native C. neoformans gene significantly improved the transformation frequencies resulting from the expression of the heterologous hphI gene. KW - DNA KW - enzymes KW - gene expression KW - genes KW - genetics KW - glyceraldehyde-3-phosphate dehydrogenase KW - introns KW - nucleotide sequences KW - open reading frames KW - promoters KW - proteins KW - yeasts KW - Cryptococcus neoformans KW - fungi KW - eukaryotes KW - Cryptococcus (Fungi) KW - Tremellaceae KW - Tremellales KW - Tremellomycetes KW - Agaricomycotina KW - Basidiomycota KW - deoxyribonucleic acid KW - DNA sequences KW - fungus KW - ORFs KW - promoter region KW - promoter sequences KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202106&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans. AU - Miyazaki, Y. AU - Geber, A. AU - Miyazaki, H. AU - Falconer, D. AU - Parkinson, T. AU - Hitchcock, C. AU - Grimberg, B. AU - Nyswaner, K. AU - Bennett, J. E. JO - Gene JF - Gene Y1 - 1999/// VL - 236 IS - 1 SP - 43 EP - 51 SN - 0378-1119 AD - Miyazaki, Y.: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH. 10 Center Drive, Bethesda, MD 20892, USA. N1 - Accession Number: 20001201517. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 59-23-4. Subject Subsets: Medical & Veterinary Mycology N2 - The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from C. albicans by homology with the Saccharomyces cerevisiae ERG3. The ERG3 ORF contained 1158 bp and encoded 386 deduced amino acids. The clone was used to transform a gal1 mutant derived from the Darlington strain of C. albicans, using galactose selection. The Darlington strain is known to lack Δ5,6 sterols, i.e. to have an erg3 phenotype. The transformant (CDTR1) contained 6 tandem integrated ERG3GAL1 repeats, had double the abundance of ERG3 transcript found in the host strain, and synthesized ergosterol, a Δ5,6 sterol. The Darlington strain had an abundance of ERG3 transcript. Both ERG3 alleles in Darlington were cloned and sequenced in order to look for changes that might explain the erg3 phenotype. One allele, called Dar-2, contained a stop codon in place of tryptophan-292. The other ERG3 allele, called Dar-1, had changes in 3 amino acids, 2 of which were conserved in 3 fungal and one plant species. EcoRI genomic fragments containing ERG3 from the Dar-1 allele and from B311, the wild-type strain, were inserted into the plasmid pRS316 and used to transform a Saccharomyces cerevisiae erg3,ura3 mutant using uracil selection. The 4.1 kb ERG3 fragments from the B311 and Dar-1 both contained 1.4 kb 5′ and 1.5 kb 3′ flanking sequences around the coding region. Transformants with ERG3 from B311 but not from Dar-1 showed restored ergosterol synthesis. One or more of these 3 deduced amino acids in the Dar-1 allele of ERG3 appeared critical for function. KW - alleles KW - amino acids KW - biosynthesis KW - DNA cloning KW - galactose KW - genes KW - genetics KW - nucleotide sequences KW - phenotypes KW - sterols KW - yeasts KW - Candida albicans KW - Saccharomyces cerevisiae KW - Saccharomycetaceae KW - fungi KW - eukaryotes KW - Candida KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Ascomycota KW - Saccharomyces KW - Saccharomycetaceae KW - DNA sequences KW - fungus KW - Hyphomycetes KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001201517&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes. AU - Gong DaWei AU - He YuFang AU - Reitman, M. L. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1999/// VL - 256 IS - 1 SP - 27 EP - 32 SN - 0006-291X AD - Gong DaWei: Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1770, USA. N1 - Accession Number: 19991411968. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition KW - cell cultures KW - fat KW - genes KW - genetics KW - genomes KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - uncoupling protein KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411968&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Thiamine deficiency in vivo produces fiber cell degeneration in mouse lenses. AU - Frederikse, P. H. AU - Farnsworth, P. AU - Zigler, J. S., Jr. JO - Biochemical and Biophysical Research Communications JF - Biochemical and Biophysical Research Communications Y1 - 1999/// VL - 258 IS - 3 SP - 703 EP - 707 SN - 0006-291X AD - Frederikse, P. H.: Building 6, Room 237, Laboratory on Mechanisms of Ocular Disease, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2735, USA. N1 - Accession Number: 20001416659. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 59-43-8. Subject Subsets: Human Nutrition KW - deficiency KW - degeneration KW - eye lens KW - eyes KW - thiamin KW - mice KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - aneurin KW - thiamine KW - vitamin B1 KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416659&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Apolipoprotein B stimulates formation of monocyte-macrophage surface-connected compartments and mediates uptake of low density lipoprotein-derived liposomes into these compartments. AU - Kruth, H. S. AU - Zhang WeiYang AU - Skarlatos, S. I. AU - Chao FeiFei JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1999/// VL - 274 IS - 11 SP - 7495 EP - 7500 SN - 0021-9258 AD - Kruth, H. S.: Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 19991407271. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition N2 - Much of the cholesterol that accumulates in atherosclerotic plaques is found within monocyte-macrophages transforming these cells into "foam cells." Native LDL does not cause foam cell formation. Treatment of LDL with cholesterol esterase converts LDL into cholesterol-rich liposomes having >90% cholesterol in unesterified form. Similar cholesterol-rich liposomes are found in early developing atherosclerotic plaques surrounding foam cells. Cholesterol-rich liposomes produced from cholesterol esterase-treated LDL can cause human monocyte-macrophage foam cell formation inducing a 3-5-fold increase in macrophage cholesterol content of which >60% is esterified. Although cytochalasin D inhibited LDL liposome-induced macrophage cholesteryl ester accumulation, LDL liposomes did not enter macrophages by phagocytosis. Rather, the LDL liposomes induced and entered surface-connected compartments within the macrophages, a unique endocytic pathway in these cells, referred to as patocytosis by the authors. LDL liposome apoB rather than LDL liposome lipid mediated LDL liposome uptake by macrophages. This was shown by the findings that: protease treatment of the LDL liposomes prevented macrophage cholesterol accumulation; liposomes prepared from LDL lipid extracts did not cause macrophage cholesterol accumulation; and purified apoB induced and accumulated within macrophage surface-connected compartments. Although apoB mediated the macrophage uptake of LDL liposomes, this uptake did not occur through LDL, LDL receptor-related protein, or scavenger receptors. Also, LDL liposome uptake was not sensitive to treatment of macrophages with trypsin or heparinase. Cholesterol esterase-mediated transformation of LDL into cholesterol-rich liposomes is an LDL modification that: stimulates uptake of LDL cholesterol by apoB-dependent endocytosis into surface-connected compartments; and causes human monocyte-macrophage foam cell formation. KW - apolipoproteins KW - in vitro KW - liposomes KW - low density lipoprotein KW - macrophages KW - monocytes KW - uptake KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407271&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes. AU - Cociancich, S. O. AU - Park, S. S. AU - Fidock, D. A. AU - Shahabuddin, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1999/// VL - 274 IS - 18 SP - 12650 EP - 12655 SN - 0021-9258 AD - Cociancich, S. O.: Medical Entomology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bldg. 4, Rm B2-39, 9000 Rockville Pike, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 19990805456. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9000-83-3. Subject Subsets: Protozoology; Medical & Veterinary Entomology N2 - In Plasmodium-infected mosquitoes, oocysts are preferentially located at the posterior half of the posterior midgut. Because mosquitoes rest vertically after feeding, the effect of gravity on the ingested blood has been proposed as the cause of such a biased distribution. P. gallinaceum oocyst distribution was examined in the midguts of Aedes aegypti that were continuously rotated to nullify the effect of gravity and it was found that the typical pattern of oocyst distribution did not change. Invasion of the midgut epithelium by ookinetes was similarly found to be biased toward the posterior part of the posterior midgut. The effect of the distribution of vesicular ATPase (V-ATPase)-overexpressing cells that Plasmodium ookinetes preferentially use to cross the midgut epithelium on the distribution of oocysts was investigated. An antiserum raised against recombinant A. aegypti V-ATPase B subunit indicated that most V-ATPase-overexpressing cells in A. aegypti and Anopheles gambiae are localized at the posterior part of the posterior midgut. It was concluded that the typical distribution of oocysts on the mosquito midgut is attributable to the presence and the spatial distribution of the V-ATPase-overexpressing cells in the midgut epithelium. KW - adenosinetriphosphatase KW - cells KW - epithelium KW - host parasite relationships KW - midgut KW - oocysts KW - ookinetes KW - parasites KW - spatial distribution KW - Aedes aegypti KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Plasmodium gallinaceum KW - protozoa KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - ATPase KW - mosquitoes KW - parasite host relationships KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805456&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Specificity of ascorbate analogs for ascorbate transport: synthesis and detection of [125I]6-deoxy-6-iodo-L-ascorbic acid and characterization of its ascorbate-specific transport properties. AU - Rumsey, S. C. AU - Welch, R. W. AU - Garraffo, H. M. AU - Ge Ping AU - Lu ShouFu AU - Crossman, A. T. AU - Kirk, K. L. AU - Levine, M. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1999/// VL - 274 IS - 33 SP - 23215 EP - 23222 SN - 0021-9258 AD - Rumsey, S. C.: Molecular and Clinical Nutrition Section, Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1372, USA. N1 - Accession Number: 19991415525. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Cellular ascorbic acid accumulation occurs in vitro by two distinct mechanisms: transport of ascorbate itself or transport and subsequent intracellular reduction of its oxidized product, dehydroascorbic acid. It is unclear which mechanism predominates in vivo. An easily detectable compound resembling ascorbate but not dehydroascorbic acid could be a powerful tool to distinguish the two transport activities. To identify compounds, 21 ascorbate analogues were tested for inhibition of ascorbate or dehydroascorbic acid transport in human fibroblasts. The most effective analogues, competitive inhibitors of ascorbate transport with Ki values of 3 µM, were 6-deoxy-6-bromo-, 6-deoxy-6-chloro-, and 6-deoxy-6-iodo-L-ascorbate. No analogue inhibited dehydroascorbic acid transport. Using substitution chemistry, [125I]6-deoxy-6-iodo-L-ascorbate (1.4×104 mCi/mmol) was synthesized. HPLC detection methods were developed for radiolabelled and nonradiolabelled compounds, and transport kinetics of both compounds were characterized. Transport was sodium-dependent, inhibited by excess ascorbate, and similar to that of ascorbate. Transport of oxidized ascorbate and oxidized 6-deoxy-6-iodo-L-ascorbate was investigated using Xenopus laevis oocytes expressing glucose transporter isoform GLUT1 or GLUT3. Oxidation of ascorbate or its analogue in media increased uptake of ascorbate in oocytes by 6-13-fold compared with control but not that of 6-deoxy-6-iodo-L-ascorbate. Therefore, 6-deoxy-6-iodo-L-ascorbate, although an effective inhibitor of ascorbate transport, either in its reduced or oxidized form was not a substrate for dehydroascorbic acid transport. Thus, radiolabelled and nonradiolabelled 6-deoxy-6-iodo-L-ascorbate provide a new means for discriminating dehydroascorbic acid and ascorbate transport in ascorbate recycling. KW - analogues KW - ascorbic acid KW - characterization KW - detection KW - fibroblasts KW - in vitro KW - inhibition KW - inhibitors KW - kinetics KW - properties KW - recycling KW - synthesis KW - transport KW - uptake KW - man KW - Xenopus laevis KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Xenopus KW - Pipidae KW - Anura KW - Amphibia KW - analogs KW - transportation KW - vitamin C KW - Animal Models of Human Nutrition (VV140) KW - Animal Nutrition (Physiology) (LL510) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415525&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Neuronal sensitivity to tetanus toxin requires gangliosides. AU - Williamson, L. C. AU - Bateman, K. E. AU - Clifford, J. C. M. AU - Neale, E. A. JO - Journal of Biological Chemistry JF - Journal of Biological Chemistry Y1 - 1999/// VL - 274 IS - 35 SP - 25173 EP - 25180 SN - 0021-9258 AD - Williamson, L. C.: Laboratory of Developmental Neurobiology, NICHHD, National Institutes of Health, Bethesda, MD 20892-4480, USA. N1 - Accession Number: 19991202894. Publication Type: Journal Article. Language: English. Number of References: 44 ref. N2 - Tetanus toxin binding and action in spinal cord cell cultures grown in the presence of fumonisin B1, an inhibitor of ganglioside synthesis, was examined. Mouse spinal cord neurons grown for 3 weeks in culture in 20 µM fumonisin B1 developed dendrites, axons, and synaptic terminals similar to untreated neurons, even though thin layer chromatography showed a >90% inhibition of ganglioside synthesis. Absence of tetanus and cholera toxin binding by toxin-horseradish peroxidase conjugates or immunofluorescence further indicated loss of mono- and polysialogangliosides. In contrast to control cultures, tetanus toxin added to fumonisin B1-treated cultures did not block potassium-stimulated glycine release, inhibit activity-dependent uptake of FM1-43, or abolish immunoreactivity for vesicle-associated membrane protein, the toxin substrate. Supplementing fumonisin B1-treated cultures with mixed brain gangliosides completely restored the ability of tetanus toxin to bind to the neuronal surface and to block neurotransmitter release. These data demonstrate that fumonisin B1 protects against toxin-induced synaptic blockade and that gangliosides are a necessary component of the receptor mechanism for tetanus toxin. KW - bacterial toxins KW - cell cultures KW - cholera KW - fumonisins KW - gangliosides KW - inhibition KW - mycotoxins KW - neurons KW - neurotransmitters KW - paralysis KW - receptors KW - tetanus KW - toxins KW - Vibrio cholerae KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - bacterium KW - fungal toxins KW - lockjaw KW - nerve cells KW - neurones KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202894&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats. AU - Horská, A. AU - Brant, L. J. AU - Ingram, D. K. AU - Hansford, R. G. AU - Roth, G. S. AU - Spencer, R. G. S. JO - American Journal of Physiology JF - American Journal of Physiology Y1 - 1999/// VL - 276 IS - 4 SP - E766 EP - E773 SN - 0002-9513 AD - Horská, A.: Nuclear Magnetic Resonance Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. N1 - Accession Number: 19991407833. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 67-07-2. Subject Subsets: Human Nutrition N2 - The hypothesis that long-term caloric [energy] restriction and exercise would have beneficial effects on muscle bioenergetics and performance in the rat was examined. Each of these interventions is known to increase longevity and bioenergetic improvements are thought to be important in this phenomenon. Rats that underwent long-term caloric restriction and were sedentary, ad libitum-fed rats permitted to exercise by daily spontaneous wheel running (AE) and the combination of the dietary and exercise interventions (RE) were studied. Ad libitum-fed, sedentary rats comprised the control group. 31P NMR spectra of the gastrocnemius muscle (GM) were collected in vivo at rest and during 2 periods of electrical stimulation. Neither caloric restriction nor exercise affected the ratio of phosphocreatine to ATP or pH at rest. During the first stimulation and after recovery, the RE group had a smaller decline in pH than did the other groups (P<0.05). During the second period of stimulation, the decrease in pH was much smaller in all groups than during the first stimulation, with no differences observed among the groups. The combination of caloric restriction and exercise resulted in an attenuation in the decline in developed force during the second period of stimulation (P<0.05). A biochemical correlate of this was a significantly higher concentration of citrate synthase in the GM samples from the RE rats compared with the AE rats (32.7±5.4 vs. 17.6±5.7 µmol min-1 g-1; P<0.05). It is concluded that there is a synergistic effect of long-term caloric restriction and free exercise on muscle bioenergetics during electrical stimulation. KW - bioenergetics KW - energy intake KW - energy relations KW - exercise KW - kinetics KW - metabolism KW - muscles KW - pH KW - phosphocreatine KW - restricted feeding KW - rats KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - creatine phosphate KW - hydrogen ion concentration KW - potential of hydrogen KW - Animal Nutrition (Physiology) (LL510) KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407833&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. AU - Culnane, M. AU - Fowler, M. G. AU - Lee, S. S. AU - McSherry, G. AU - Brady, M. AU - O'Donnell, K. AU - Mofenson, L. AU - Gortmaker, S. L. AU - Shapiro, D. E. AU - Scott, G. AU - Jimenez, E. AU - Moore, E. C. AU - Diaz, C. AU - Flynn, P. M. AU - Cunningham, B. AU - Oleske, J. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1999/// VL - 281 IS - 2 SP - 151 EP - 157 SN - 0098-7484 AD - Culnane, M.: MS, CRNP, Pediatric Medicine Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-7620, USA. N1 - Accession Number: 19992002055. Publication Type: Journal Article. Corporate Author: USA, Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams Language: English. Number of References: 21 ref. Registry Number: 30516-87-1. Subject Subsets: Public Health N2 - To evaluate the long-term effects of in utero exposure to zidovudine vs placebo among a randomized cohort of uninfected children, a prospective cohort study was conducted based on data collected during Pediatric AIDS Clinical Trials Group Protocol 076, a perinatal zidovudine HIV prevention trial, and Protocol 219, a long-term observational protocol. 234 uninfected children born in the USA to 230 HIV-infected women enrolled in Protocol 076 and followed up through February 28, 1997, in Protocol 219 (122 in the zidovudine group and 112 in the placebo group) were studied. Physical growth measurements, immunological parameters, cognitive/developmental function, occurrence of neoplasms, and mortality data were assessed every 6 months for children <24 months and yearly thereafter or as clinically indicated. Baseline echocardiogram and funduscopic evaluations were collected before 36 months of age. Median age of children at time of last follow-up visit was 4.2 years (range, 3.2-5.6 years). There were no significant differences between children exposed to zidovudine and those who received placebo in terms of sequential data on lymphocyte subsets; weight, height, and head circumference z scores; and cognitive/developmental function. No deaths or malignancies occurred. Two children (both exposed to zidovudine) are being followed up for abnormal, unexplained ophthalmic findings. One child exposed to zidovudine had a mild cardiomyopathy on echocardiogram at the age of 48 months; the child is clinically asymptomatic. It is concluded that no adverse effects were observed in HIV-uninfected children with in utero and neonatal exposure to zidovudine followed up for as long as 5.6 years. KW - adverse effects KW - children KW - exposure KW - eyes KW - fetus KW - growth KW - health KW - heart KW - human immunodeficiency viruses KW - immunity KW - infants KW - zidovudine KW - USA KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - adverse reactions KW - AZT KW - foetus KW - human immunodeficiency virus KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992002055&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus. AU - Henderson, D. K. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1999/// VL - 281 IS - 10 SP - 931 EP - 936 SN - 0098-7484 AD - Henderson, D. K.: Office of the Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992003429. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Public Health KW - animal models KW - antiviral agents KW - chemoprophylaxis KW - clinical aspects KW - efficacy KW - exposure KW - health care workers KW - human diseases KW - human immunodeficiency viruses KW - occupational hazards KW - reviews KW - safety KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003429&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Criteria and recommendations for vitamin C intake. AU - Levine, M. AU - Rumsey, S. C. AU - Daruwala, R. AU - Park, J. B. AU - Wang YaoHui JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1999/// VL - 281 IS - 15 SP - 1415 EP - 1423 SN - 0098-7484 AD - Levine, M.: National Institutes of Health, Bldg 10, Room 4D52, MSC1372, Bethesda, MD 20892, USA. N1 - Accession Number: 19991407535. Publication Type: Journal Article. Language: English. Number of References: 107 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition N2 - Recommendations for vitamin C [ascorbic acid] intake are under revision by the Food and Nutrition Board of the National Academy of Sciences. Since 1989 when the last recommended dietary allowance (RDA) of 60 mg was published, extensive biochemical, molecular, epidemiologic, and clinical data have become available. New recommendations can be based on the following 9 criteria: dietary availability, steady-state concentrations in plasma in relationship to dose, steady-state concentrations in tissues in relationship to dose, bioavailability, urine excretion, adverse effects, biochemical and molecular function in relationship to vitamin concentration, direct beneficial effects and epidemiologic observations in relationship to dose, and prevention of deficiency. These criteria were applied to the Food and Nutrition Boards new guidelines, the Dietary Reference Intakes, which include 4 reference values. The estimated average requirement (EAR) is the amount of nutrient estimated to meet the requirement of half the healthy individuals in a life-stage and gender group. Based on an EAR of 100 mg/day of vitamin C, the RDA is proposed to be 120 mg/day. If the EAR cannot be determined, an adequate intake (AI) amount is recommended instead of an RDA. The AI was estimated to be either 200 mg/day from 5 servings of fruits and vegetables or 100 mg/day of vitamin C to prevent deficiency with a margin of safety. The final classification, the tolerable upper intake level, is the highest daily level of nutrient intake that does not pose risk or adverse health effects to almost all individuals in the population. This amount is proposed to be less than 1 g of vitamin C daily. Physicians can tell patients that 5 servings of fruits and vegetables per day may be beneficial in preventing cancer and providing sufficient vitamin C intake for healthy people, and that 1 g or more of vitamin C may have adverse consequences in some people. KW - ascorbic acid KW - dietary guidelines KW - recommended dietary allowances KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - RDA KW - recommended dietary intakes KW - United States of America KW - vitamin C KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991407535&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis. AU - Whitcup, S. M. AU - Fortin, E. AU - Lindblad, A. S. AU - Griffiths, P. AU - Metcalf, J. A. AU - Robinson, M. R. AU - Manischewitz, J. AU - Baird, B. AU - Perry, C. AU - Kidd, I. M. AU - Vrabec, T. AU - Davey, R. T., Jr. AU - Falloon, J. AU - Walker, R. E. AU - Kovacs, J. A. AU - Lane, H. C. AU - Nussenblatt, R. B. AU - Smith, J. AU - Masur, H. AU - Polis, M. A. JO - JAMA, Journal of the American Medical Association JF - JAMA, Journal of the American Medical Association Y1 - 1999/// VL - 282 IS - 17 SP - 1633 EP - 1637 SN - 0098-7484 AD - Whitcup, S. M.: National Eye Institute, National Institutes of Health, 10/105221, 10 Center Dr, MSC 1863, Bethesda, MD 20892-1863, USA. N1 - Accession Number: 20002004812. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health N2 - A prospective nonrandomized interventional trial was conducted at the Clinical Center of the National Institutes of Health, Bethesda, Maryland, USA, during July 1997 to August 1999, to determine whether patients who were taking highly active antiretroviral therapy (HAART) and who had stable cytomegalovirus (CMV) retinitis could safely discontinue anti-CMV therapy without reactivation of their retinitis or increase in human immunodeficiency virus (HIV) viral load. The study comprised 14 patients with stable CMV retinitis and HIV infection and CD4+ cell counts >0.15 × 109/litre and being treated with systemic anti-CMV medications and HAART. Specific anti-CMV therapy was discontinued. The main outcome measures were reactivation of CMV retinitis, development of extraocular CMV infection, detection of CMV in blood and urine, HIV burden, immunological function, quality of life, morbidity and mortality. 12 (89.7%) of 14 patients had evidence of immune recovery uveitis before anti-CMV drugs were discontinued. No patient had reactivation of CMV retinitis or development of extraocular CMV disease during mean follow-up of 16.4 months (range, 8.3-22.0 months) without anti-CMV therapy. Human immunodeficiency viral load remained stable following cessation of anti-CMV medications. Blood and urine assays for CMV were briefly positive in 9 patients, but did not predict reactivation of CMV disease. Worsening immune recovery uveitis was associated with a substantial (>3 lines) vision loss in 3 patients. Maintenance anti-CMV medications were safely stopped in those patients who had stable CMV retinitis and elevated CD4+ cell counts and who were taking HAART. It is concluded that immune recovery following potent antiretroviral therapy is effective in controlling a major opportunistic infection, even in patients with a history of severe immunosuppression. KW - acquired immune deficiency syndrome KW - antiviral agents KW - CD4+ lymphocytes KW - clinical aspects KW - disease course KW - drug therapy KW - follow up KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - immunocompromised hosts KW - morbidity KW - mortality KW - opportunistic infections KW - relapse KW - retinitis KW - uveitis KW - viral load KW - vision KW - Maryland KW - USA KW - Human herpesvirus 5 KW - man KW - Cytomegalovirus KW - Betaherpesvirinae KW - Herpesviridae KW - dsDNA viruses KW - DNA viruses KW - viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - South Atlantic States of USA KW - Southern States of USA KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - AIDS KW - CD4+ cells KW - chemotherapy KW - clinical picture KW - death rate KW - disease progression KW - human cytomegalovirus KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - recurrence of disease KW - relapses KW - sight KW - T4 lymphocytes KW - United States of America KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004812&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. AU - George, K. M. AU - Chatterjee, D. AU - Gunawardana, G. AU - Welty, D. AU - Hayman, J. AU - Lee, R. AU - Small, P. L. C. JO - Science (Washington) JF - Science (Washington) Y1 - 1999/// VL - 283 IS - 5403 SP - 854 EP - 857 SN - 0036-8075 AD - George, K. M.: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. N1 - Accession Number: 19992005112. Publication Type: Journal Article. Language: English. Number of References: 25 ref. N2 - M. ulcerans is the causative agent of Buruli ulcer, a severe human skin disease that occurs primarily in Africa and Australia. Infection with M. ulcerans results in persistent severe necrosis without an acute inflammatory response. The presence of histopathological changes distant from the site of infection suggested that pathogenesis might be toxin mediated. A polyketide-derived macrolide designated mycolactone was isolated that causes cytopathicity and cell cycle arrest in cultured L929 murine fibroblasts. Intradermal inoculation of purified toxin into guineapigs produced a lesion similar to that of Buruli ulcer in humans. This toxin may represent one of a family of virulence factors associated with pathology in mycobacterial diseases such as leprosy and tuberculosis. KW - bacterial toxins KW - cell cycle KW - cytopathogenicity KW - fibroblasts KW - histopathology KW - infections KW - leprosy KW - mycobacterial diseases KW - necrosis KW - pathogenesis KW - pathology KW - skin KW - skin diseases KW - toxins KW - tuberculosis KW - ulcers KW - virulence KW - Africa KW - Australia KW - guineapigs KW - man KW - Mycobacterium KW - Mycobacterium ulcerans KW - Cavia KW - Caviidae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - Mycobacteriaceae KW - Corynebacterineae KW - Actinomycetales KW - Actinobacteridae KW - Actinobacteria KW - Bacteria KW - prokaryotes KW - Mycobacterium KW - APEC countries KW - Australasia KW - Oceania KW - Commonwealth of Nations KW - Developed Countries KW - OECD Countries KW - bacterium KW - dermatoses KW - dermis KW - guinea pigs KW - mycobacterial infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005112&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. AU - Carrington, M. AU - Nelson, G. W. AU - Martin, M. P. AU - Kissner, T. AU - Vlahov, D. AU - Goedert, J. J. AU - Kaslow, R. AU - Buchbinder, S. AU - Hoots, K. AU - O'Brien, S. J. JO - Science (Washington) JF - Science (Washington) Y1 - 1999/// VL - 283 IS - 5408 SP - 1748 EP - 1752 SN - 0036-8075 AD - Carrington, M.: Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute (NCI), Frederick, MD 21702-1201, USA. N1 - Accession Number: 19992003742. Publication Type: Journal Article. Language: English. Number of References: 42 ref. N2 - A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex (human leukocyte antigen (HLA) class I and class II) is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci (A, B and C) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus-type 1 (HIV-1), whereas individuals who were homozygous for one or more loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of AIDS-defining conditions in Caucasians. The extended survival of 28-40% of HIV-1-infected Caucasian patients who avoided AIDS for 10 or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both. KW - acquired immune deficiency syndrome KW - antigens KW - disease course KW - genes KW - heterozygosity KW - HIV-1 infections KW - homozygosity KW - human diseases KW - human leukocyte antigens KW - major histocompatibility complex KW - survival KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - antigenicity KW - disease progression KW - histocompatibility complex KW - human immunodeficiency virus type 1 KW - immunogens KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003742&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. AU - Schaeffer, E. M. AU - Debnath, J. AU - Yap, G. AU - McVicar, D. AU - Liao, X. C. AU - Littman, D. R. AU - Sher, A. AU - Varmus, H. E. AU - Lenardo, M. J. AU - Schwartzberg, P. L. JO - Science (Washington) JF - Science (Washington) Y1 - 1999/// VL - 284 IS - 5414 SP - 638 EP - 641 SN - 0036-8075 AD - Schaeffer, E. M.: National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. N1 - Accession Number: 19990804719. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 60-18-4. Subject Subsets: Protozoology N2 - Combined deletion in mice of 2 Tec kinases, Rlk and Itk, caused marked defects in T cell receptor (TCR) responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact in rlk-/-itk-/- cells, but intermediate events including inositol trisphosphate production, calcium mobilization, and mitogen-activated protein kinase activation were impaired, establishing Tec kinases as critical regulators of TCR signalling required for phospholipase C-γ activation. KW - apoptosis KW - cytokines KW - experimental infections KW - immune response KW - immunity KW - in vitro KW - kinases KW - laboratory animals KW - parasites KW - receptors KW - T lymphocytes KW - tyrosine KW - mice KW - protozoa KW - Toxoplasma gondii KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - invertebrates KW - Toxoplasma KW - Sarcocystidae KW - Eucoccidiorida KW - Apicomplexa KW - Protozoa KW - immunity reactions KW - immunological reactions KW - T cells KW - Host Resistance and Immunity (HH600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804719&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. AU - Su XinZhuan AU - Ferdig, M. T. AU - Huang YaMing AU - Huynh, C. Q. AU - Liu, A. AU - You JingTao AU - Wootton, J. C. AU - Wellems, T. E. JO - Science (Washington) JF - Science (Washington) Y1 - 1999/// VL - 286 IS - 5443 SP - 1351 EP - 1353 SN - 0036-8075 AD - Su XinZhuan: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000804821. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology N2 - Genetic investigations of malaria require a genome-wide, high-resolution linkage map of Plasmodium falciparum. A genetic cross is reported that was used to construct such a map from 901 markers that fall into 14 inferred linkage groups corresponding to the 14 nuclear chromosomes. Meiotic crossover activity in the genome proved high (17 kilobases per centimorgan) and notably uniform over chromosome length. Gene conversion events and spontaneous microsatellite length changes were evident in the inheritance data. The markers, map and recombination parameters are facilitating genome sequence assembly, localization of determinants for such traits as virulence and drug resistance, and genetic studies of parasite field populations. KW - chromosomes KW - drug resistance KW - gene mapping KW - genes KW - genetic markers KW - genetics KW - genomes KW - linkage KW - meiosis KW - microsatellites KW - molecular genetics KW - parasites KW - population genetics KW - recombination KW - virulence KW - Plasmodium falciparum KW - protozoa KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - animals KW - eukaryotes KW - biochemical genetics KW - genetic recombination KW - minisatellites KW - reduction division KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Animal Genetics (LL220) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804821&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines. AU - Huynh, C. Q. AU - Zieler, H. JO - Journal of Molecular Biology JF - Journal of Molecular Biology Y1 - 1999/// VL - 288 IS - 1 SP - 13 EP - 20 SN - 0022-2836 AD - Huynh, C. Q.: Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. N1 - Accession Number: 20000506676. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology N2 - A series of plasmid vectors for the expression of foreign genes in insects or insect cell lines was constructed and tested using Aedes albopictus C6/36 cells and Anopheles gambiae embryos. KW - cell lines KW - gene expression KW - genes KW - genetic engineering KW - genetic vectors KW - genetically engineered organisms KW - molecular genetics KW - transgenic animals KW - Aedes albopictus KW - Anopheles gambiae KW - Culicidae KW - Diptera KW - Aedes KW - Culicidae KW - Diptera KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Anopheles KW - Asian tiger mosquito KW - biochemical genetics KW - cloning vectors KW - genetic manipulation KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - mosquitoes KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000) KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology] KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000506676&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Studies on vaccines against cholera. Synthesis of neoglycoconjugates from the hexasaccharide determinant of Vibrio cholerae O:1, serotype Ogawa, by single-point attachment or by attachment of the hapten in the form of clusters. AU - Zhang Jian AU - Kováč, P. JO - Carbohydrate Research JF - Carbohydrate Research Y1 - 1999/// VL - 321 IS - 3/4 SP - 157 EP - 167 SN - 0008-6215 AD - Zhang Jian: National Institutes of Health, NIDDK, Laboratory of Medicinal Chemistry, 8 Center Drive, Bethesda, MD 20892-0815, USA. N1 - Accession Number: 20002016394. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Tropical Diseases N2 - The terminal hexasaccharide of the O-antigen of Vibrio cholerae O:1, serotype Ogawa, has been synthesized in the form of a glycoside whose aglycon (linker) allows conjugation to carrier proteins by reductive amination. The conjugate obtained from direct, single-point attachment of the linker-equipped hapten to chicken serum albumin (CSA) contained seven hapten residues/CSA. A neoglycoconjugate containing the carbohydrate antigen in the form of clusters was obtained using, as a hapten subcarrier, an oligopeptide containing 16 amino groups. It was treated with a limited amount of hapten, to give a hapten-carrying subcarrier (HCS). Subsequent conjugation of HCS to CSA, using squaric acid diethyl ester as a conjugation reagent, gave a cross-linked, glycocluster conjugate containing 51% (w/w) of the carbohydrate. KW - albumins KW - antigens KW - binding proteins KW - carbohydrates KW - human diseases KW - proteins KW - serotypes KW - vaccines KW - man KW - Vibrio cholerae KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Vibrio KW - Vibrionaceae KW - Vibrionales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - antigenicity KW - bacterium KW - carrier proteins KW - immunogens KW - saccharides KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016394&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. AU - Ciolino, H. P. AU - Daschner, P. J. AU - Yeh, G. C. JO - Biochemical Journal (London) JF - Biochemical Journal (London) Y1 - 1999/// VL - 340 IS - 3 SP - 715 EP - 722 SN - 0264-6021 AD - Ciolino, H. P.: Cellular Defense and Carcinogenesis Section, Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, National Institutes of Health, Building 560, Room 12-05, P. O. Box B, Frederick, MD, 21702-1201, USA. N1 - Accession Number: 19991410276. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9035-51-2, 520-18-3, 117-39-5. Subject Subsets: Human Nutrition N2 - Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P-450 1A1) is mediated by the aryl hydrocarbon receptor (AhR). In the present study the effect of the common dietary polyphenolic compounds quercetin and kaempferol on the transcription of CYP1A1 and the function of the AhR in MCF-7 was investigated in human breast cancer cells. Quercetin caused a time- and concentration-dependent increase in the amount of CYP1A1 mRNA and CYP1A1 enzyme activity in MCF-7 cells. The increase in CYP1A1 mRNA caused by quercetin was prevented by the transcription inhibitor actinomycin D. Quercetin also caused an increase in the transcription of a chloramphenicol reporter vector containing the CYP1A1 promoter. Quercetin failed to induce CYP1A1 enzyme activity in AhR-deficient MCF-7 cells. Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter. These results indicate that quercetin's effect is mediated by the AhR. Kaempferol did not affect CYP1A1 expression by itself but it inhibited the transcription of CYP1A1 induced by the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as measured by a decrease in TCDD-induced CYP1A1 promoter-driven reporter vector activity, and CYP1A1 mRNA in cells. Kaempferol also abolished TCDD-induced XRE binding in a gel-shift assay. Both compounds were able to compete with TCDD for binding to a cytosolic extract of MCF-7 cells. Known ligands of the AhR are, for the most part, man-made compounds such as halogenated and polycyclic aromatic hydrocarbons. These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription. KW - breast cancer KW - cell cultures KW - cytochrome P-450 KW - flavonols KW - gene expression KW - kaempferol KW - mammary gland neoplasms KW - neoplasms KW - polyphenols KW - quercetin KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - cancers KW - mammary tumour KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Physiology of Human Nutrition (VV120) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410276&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Hyper-IgE syndrome with recurrent infections - an autosomal dominant multisystem disorder. AU - Grimbacher, B. AU - Holland, S. M. AU - Gallin, J. I. AU - Greenberg, F. AU - Hill, S. C. AU - Malech, H. L. AU - Miller, J. A. AU - O'Connell, A. C. AU - Puck, J. M. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 340 IS - 9 SP - 692 EP - 702 SN - 0028-4793 AD - Grimbacher, B.: Genetics and Molecular Biology Branch, National Institutes of Health, Bethesda, MD, USA. N1 - Accession Number: 19992003269. Publication Type: Journal Article. Language: English. Number of References: 62 ref. N2 - The hyper-IgE syndrome with recurrent infections is a rare immunodeficiency characterized by recurrent skin and pulmonary abscesses and extremely elevated levels of IgE in serum. Associated facial and skeletal features have been recognized, but their frequency is unknown, and the genetic basis of the hyper-IgE syndrome is poorly understood. 30 patients with the hyper-IgE syndrome and 70 of their relatives were studied. The authors took histories, reviewed records, performed physical and dental examinations, took anthropometric measurements, and conducted laboratory studies. Nonimmunologic features of the hyperIgE syndrome were present in all patients older than 8 years. 72% had the previously unrecognized feature of failure or delay of shedding of the primary teeth owing to lack of root resorption. Common findings among patients were recurrent fractures (in 57% of patients), hyperextensible joints (in 68%), and scoliosis (in 76% of patients 16 years of age or older). The classic triad of abscesses, pneumonia, and an elevated IgE level was identified in 77% of all patients and in 85% of those older than 8. In 6 of 23 adults (26%), IgE levels declined over time and came closer to or fell within the normal range. Autosomal dominant transmission of the hyper-IgE syndrome was found, but with variable expressivity. Of the 27 relatives at risk for inheriting the hyper-IgE syndrome, 10 were fully affected, 11 were unaffected, and 6 had combinations of mild immunologic, dental, and skeletal features of the hyper-IgE syndrome. The hyper-IgE syndrome is a multisystem disorder that affects the dentition, the skeleton, connective tissue, and the immune system. It is inherited as a single-locus autosomal dominant trait with variable expressivity. KW - clinical aspects KW - hereditary diseases KW - human diseases KW - symptoms KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - clinical picture KW - hyper-IgE syndrome KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003269&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. AU - Walsh, T. J. AU - Finberg, R. W. AU - Arndt, C. AU - Hiemenz, J. AU - Schwartz, C. AU - Bodensteiner, D. AU - Pappas, P. AU - Seibel, N. AU - Greenberg, R. N. AU - Dummer, S. AU - Schuster, M. AU - Holcenberg, J. S. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 340 IS - 10 SP - 764 EP - 771 SN - 0028-4793 AD - Walsh, T. J.: National Cancer Institute, Bethesda, MD 20892, USA. N1 - Accession Number: 19991200962. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology N2 - A randomized, double-blind, multicentre trial comparing liposomal amphotericin B with conventional amphotericin B as empirical antifungal therapy was conducted in the USA. The mean duration of therapy was 10.8 days for liposomal amphotericin B (343 patients) and 10.3 days for conventional amphotericin B (344 patients). The composite rates of successful treatment were similar (50% for liposomal amphotericin B and 49% for conventional amphotericin B) and were independent of the use of antifungal prophylaxis or colony-stimulating factors. The outcomes were similar with liposomal amphotericin B and conventional amphotericin B with respect to survival (93% and 90%, respectively), resolution of fever (58% and 58%) and discontinuation of the study drug because of toxic effects or lack of efficacy (14% and 19%). There were fewer proved breakthrough fungal infections among patients treated with liposomal amphotericin B (11 patients, 3.2%) than among those treated with conventional amphotericin B (27 patients, 7.8%, P=0.009). Fungal infections were due to Aspergillus, Candida and Fusarium, and 1 episode of zygomycosis. With the liposomal preparation significantly fewer patients had infusion-related fever (17% vs. 44%), chills or rigors (18% vs. 54%) and other reactions, including hypotension, hypertension and hypoxia. Nephrotoxic effects (defined by a serum creatinine level 2-fold the upper limit of normal) were significantly less frequent among patients treated with liposomal amphotericin B (19%) than among those treated with conventional amphotericin B (34%, P<0.001). Liposomal amphotericin B is as effective as conventional amphotericin B for empirical antifungal therapy in patients with fever and neutropenia, and it is associated with fewer breakthrough fungal infections, less infusion-related toxicity, and less nephrotoxicity. KW - amphotericin B KW - antifungal agents KW - application methods KW - clinical trials KW - colony stimulating factor KW - drug formulations KW - drug therapy KW - drug toxicity KW - efficacy KW - human diseases KW - immunocompromised hosts KW - infections KW - liposomes KW - mycoses KW - nephrotoxicity KW - opportunistic infections KW - predisposition KW - prophylaxis KW - zygomycosis KW - USA KW - Aspergillus KW - Candida KW - fungi KW - Fusarium KW - man KW - Trichocomaceae KW - Eurotiales KW - Eurotiomycetes KW - Pezizomycotina KW - Ascomycota KW - fungi KW - eukaryotes KW - Saccharomycetales KW - Saccharomycetes KW - Saccharomycotina KW - Nectriaceae KW - Hypocreales KW - Sordariomycetes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - chemotherapy KW - fungistats KW - fungus KW - Hyphomycetes KW - phycomycosis KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200962&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1. A meta-analysis of 15 prospective cohort studies. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 340 IS - 13 SP - 977 EP - 987 SN - 0028-4793 AD - Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Executive Bldg., Rm. 4B11F, 6100 Executive Blvd. MSC 7510, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 19992006532. Publication Type: Journal Article. Corporate Author: International Perinatal HIV Group Language: English. Number of References: 53 ref. Subject Subsets: Public Health N2 - To evaluate the relation between elective caesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), North American and European studies of ≥100 mother-child pairs were included in the meta-analysis. Elective caesarean sections were defined as those performed before onset of labour and rupture of membranes. The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approx. 50% with elective caesarean section, as compared with other modes of delivery (adjusted odds ratio (AOR) 0.43; 95% confidence interval (CI) 0.33-0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approx. 87% with both elective caesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum and neonatal periods, as compared with other modes of delivery and the absence of therapy (AOR 0.13; 95% CI 0.09-0.19). Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum and neonatal periods, rates of vertical transmission were 2.0% among the 196 mothers who underwent elective caesarean section and 7.3% among the 1255 mothers with other modes of delivery. KW - caesarean section KW - childbirth KW - disease prevention KW - human diseases KW - maternal transmission KW - neonates KW - pregnancy KW - risk factors KW - vertical transmission KW - viral diseases KW - women KW - Europe KW - North America KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - America KW - gestation KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - newborn infants KW - viral infections KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006532&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. AU - Freifeld, A. AU - Marchigiani, D. AU - Walsh, T. AU - Chanock, S. AU - Lewis, L. AU - Hiemenz, J. AU - Hiemenz, S. AU - Hicks, J. E. AU - Gill, V. AU - Steinberg, S. M. AU - Pizzo, P. A. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 341 IS - 5 SP - 305 EP - 311 SN - 0028-4793 AD - Freifeld, A.: National Cancer Institute, National Institutes of Health Bethesda, Maryland, USA. N1 - Accession Number: 19992011830. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 72558-82-8, 85721-33-1. N2 - A randomized, doubleblind, placebo-controlled study of patients (5 to 74 years of age) who had fever and neutropenia during chemotherapy for cancer was conducted during May 1992 to July 1997 in the USA. Neutropenia was expected to be present for no more than 10 days in these patients, and they had to have no other underlying conditions. Patients were assigned to receive either oral ciprofloxacin plus amoxicillin-clavulanate or intravenous ceftazidime. They were hospitalized until fever and neutropenia resolved. 116 episodes were included in each group (84 patients in the oral-therapy group and 79 patients in the intravenous-therapy group). The mean neutrophil counts at admission were 81 per cubic millimeter and 84 per cubic millimeter, respectively; the mean duration of neutropenia was 3.4 and 3.8 days, respectively. Treatment was successful without the need for modifications in 71% of episodes in the oral-therapy group and 67% of episodes in the intravenous-therapy group (difference between groups, 3%; 95% confidence interval, -8% to 15%; P=0.48). Treatment was considered to have failed because of the need for modifications in the regimen in 13% and 32% of episodes, respectively (P<0.001) and because of the patient's inability to tolerate the regimen in 16% and 1% of episodes, respectively (P<0.001). There were no deaths. The incidence of intolerance of the oral antibiotics was 16% compared with 8% for placebo (P=0.07). It is concluded that in hospitalized low-risk patients who have fever and neutropenia during cancer chemotherapy, empirical therapy with oral ciprofloxacin and amoxicillin-clavulanate is safe and effective. KW - amoxicillin KW - antibiotics KW - bacterial diseases KW - ceftazidime KW - ciprofloxacin KW - drug therapy KW - fever KW - human diseases KW - immunocompromised hosts KW - neutropenia KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - amoxycillin KW - bacterial infections KW - bacterioses KW - bacterium KW - chemotherapy KW - pyrexia KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011830&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. AU - Mofenson, L. M. AU - Lambert, J. S. AU - Stiehm, E. R. AU - Bethel, J. AU - Meyer, W. A., III AU - Whitehouse, J. AU - Moye, J., Jr. AU - Reichelderfer, P. AU - Harris, D. R. AU - Fowler, M. G. AU - Mathieson, B. J. AU - Nemo, G. J. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 341 IS - 6 SP - 385 EP - 393 SN - 0028-4793 AD - Mofenson, L. M.: Pediatric, Adolescent and Maternal AIDS Branch, National Institutes of Health, Bethesda, Maryland, USA. N1 - Accession Number: 19992010562. Publication Type: Journal Article. Corporate Author: USA, Pediatric AIDS Clinical Trials Group Study 185 Team Language: English. Number of References: 43 ref. Registry Number: 30516-87-1. Subject Subsets: Public Health; Tropical Diseases N2 - The effects were investigated of maternal, obstetrical and infant-related characteristics and maternal virological and immunological variables on the risk of perinatal transmission of HIV-1 among 480 women and their infants, all of whom received zidovudine. The women and infants were participating in a phase 3 trial of passive immunoprophylaxis for the prevention of perinatal transmission, conducted between October 1993 and March 1997 at 53 clinical sites in USA and Puerto Rico. In univariate analyses, the risk of perinatal transmission was associated with each of the following: decreased maternal CD4+ lymphocyte counts at base line; decreased maternal HIV-1 p24 antibody levels at base line and delivery; increased maternal HIV-1 titre at base line and delivery; increased maternal HIV-1 RNA levels at base line and delivery; and the presence of chorioamnionitis at delivery. In multivariate analyses, the only independent risk factor was the maternal HIV-1 RNA level at base line (odds ratio for transmission, 2.4 per log increase in the number of copies; 95 percent confidence interval, 1.2 to 4.7; P=0.02) and at delivery (odds ratio, 3.4; 95% confidence interval, 1.7 to 6.8; P=0.001). There was no perinatal transmission of HIV-1 among the 84 women who had HIV-1 levels below the limit of detection (500 copies per ml) at base line or the 107 women who had undetectable levels at delivery. Among pregnant women and their infants, all treated with zidovudine, the maternal plasma HIV-1 RNA level was the best predictor of the risk of perinatal transmission of HIV-1. It is concluded that antiretroviral therapy that reduces the HIV-1 RNA level to below 500 copies per ml appears to minimize the risk of perinatal transmission as well as improve the health of the women. KW - disease transmission KW - drug therapy KW - HIV infections KW - human diseases KW - maternal transmission KW - neonates KW - pregnancy KW - prophylaxis KW - risk factors KW - women KW - zidovudine KW - Puerto Rico KW - USA KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developing Countries KW - Greater Antilles KW - Antilles KW - Caribbean KW - America KW - Latin America KW - APEC countries KW - Developed Countries KW - North America KW - OECD Countries KW - AZT KW - chemotherapy KW - gestation KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - newborn infants KW - Porto Rico KW - United States of America KW - Pesticides and Drugs (General) (HH400) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Human Reproduction and Development (VV060) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992010562&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - The AIDS epidemic considerations for the 21st century. AU - Fauci, A. S. JO - New England Journal of Medicine JF - New England Journal of Medicine Y1 - 1999/// VL - 341 IS - 14 SP - 1046 EP - 1050 SN - 0028-4793 AD - Fauci, A. S.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20002005354. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health N2 - The origins of human immunodeficiency virus, the scope of the epidemic, the successes and limitations of antiretroviral therapy, prevention of HIV infection, and development of an HIV vaccine are discussed. KW - acquired immune deficiency syndrome KW - drug therapy KW - epidemics KW - epidemiology KW - human diseases KW - human immunodeficiency viruses KW - prevention KW - reviews KW - vaccine development KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - human immunodeficiency virus KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005354&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Therapeutic vaccines for preventing AIDS: their use with HAART. AU - Hoff, R. AU - McNamara, J. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1999/// VL - 353 IS - 9166 SP - 1723 EP - 1724 SN - 0140-6736 AD - Hoff, R.: Vaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. N1 - Accession Number: 20002006608. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health N2 - A commentary on the studies conducted by Sandström, E., et al. (The Lancet (1999) 353, 1735-1742), Rosenberg, E.S., et al. (Science, (1997) 278, 1447-1450) and Valentine, F.T., et al. (Conference Supplement 12th World AIDS Conference, Geneva, Switzerland, between 28 June and 3 July 1998) on the use of immunotherapy in human immunodeficiency virus type 1 (HIV-1) infections is presented. KW - acquired immune deficiency syndrome KW - antiviral agents KW - disease prevention KW - drug therapy KW - HIV-1 infections KW - human diseases KW - immunization KW - immunotherapy KW - vaccines KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - AIDS KW - chemotherapy KW - human immunodeficiency virus type 1 KW - immune sensitization KW - Pesticides and Drugs; Control (HH405) (New March 2000) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) KW - Host Resistance and Immunity (HH600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006608&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Human T-lymphotropic virus type I infection. AU - Manns, A. AU - Hisada, M. AU - Grenade, L. la AU - la Grenade, L. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1999/// VL - 353 IS - 9168 SP - 1951 EP - 1958 SN - 0140-6736 AD - Manns, A.: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. N1 - Accession Number: 19992008855. Publication Type: Journal Article. Language: English. Number of References: 82 ref. Subject Subsets: Tropical Diseases; Public Health N2 - Human T-cell lymphotropic virus type I (HTLV-I) is the first human retrovirus to be associated with malignant disease-namely, adult T-cell leukaemia/lymphoma. HTLV-I has also been associated with several non-malignant conditions, notably the chronic neurodegenerative disorder, HTLV-I associated myelopathy (also known as tropical spastic paraparesis), infective dermatitis of children and uveitis. More recent evidence points to disease associations not previously linked to HTLV-I. Thus, the disease spectrum of HTLV-I is not fully known. HTLV-I has a worldwide distribution with major endemic foci in the Caribbean and southern Japan. The public health importance is confirmed by the major routes of transmission, which are mother-to-child, blood transfusion, and sexual activity. Unfortunately, no vaccine is available yet and there is no proven treatment for advanced HTLV-I disease. KW - dermatitis KW - disease transmission KW - epidemiology KW - HTLV infections KW - human diseases KW - leukaemia KW - lymphoma KW - myelopathy KW - reviews KW - tropical spastic paraparesis KW - uveitis KW - Deltaretrovirus KW - human T-cell lymphotropic virus KW - man KW - Deltaretrovirus KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - blood cancer KW - HTLV-BLV group KW - human T lymphotropic virus infections KW - human T-cell leukaemia virus infections KW - human T-cell lymphotropic virus infections KW - leucaemia KW - leukemia KW - neurodegenerative disorder KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008855&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. AU - Perlmutter, S. J. AU - Leitman, S. F. AU - Garvey, M. A. AU - Hamburger, S. AU - Feldman, E. AU - Leonard, H. L. AU - Swedo, S. E. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1999/// VL - 354 IS - 9185 SP - 1153 EP - 1158 SN - 0140-6736 AD - Perlmutter, S. J.: Pediatrics and Developmental Neuropsychiatry Branch, National Institutes of Health, Bethesda, MD 20892, USA. N1 - Accession Number: 20002006972. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 308067-57-4. N2 - It was studied in the USA whether plasma exchange or intravenous immunoglobulin (IVIG) would be better than placebo (sham IVIG) in reducing severity of neuropsychiatric symptoms following infection with group A β-haemolytic streptococci. Children with severe, infection-triggered exacerbations of obsessive-compulsive disorder (OCD) or tic disorders, including Tourette syndrome, were randomly assigned treatment with plasma exchange (5 single-volume exchanges over 2 weeks), IVIG (1 g/kg daily on 2 consecutive days), or placebo (saline solution given in the same manner as IVIG). Symptom severity was rated at baseline, and at 1 month and 12 months after treatment by use of standard assessment scales for OCD, tics, anxiety, depression, and global function. 30 children entered the study and 29 completed the trial. Ten received plasma exchange, 9 IVIG, and 10 placebo. At 1 month, the IVIG and plasma-exchange groups showed striking improvements in obsessive-compulsive symptoms (mean improvement on children's Yale-Brown obsessive compulsive scale score of 12 (45%) and 13 (58%), respectively), anxiety (2.1 (31%) and 3.0 (47%) improvement on National Institute of Mental Health anxiety scale), and overall functioning (2.9 (33%) and 2.8 (35%) improvement on National Institute of Mental Health global scale). Tic symptoms were also significantly improved by plasma exchange (mean change on Tourette syndrome unified rating scale of 49%). Treatment gains were maintained at 1 year, with 14 (82%) of 17 children "much" or "very much" improved over baseline (7 of 8 for plasma exchange, 7 of 9 for IVIG). Plasma exchange and IVIG were both effective in lessening of symptom severity for children with infection-triggered OCD and tic disorders. KW - autoimmunity KW - blood plasma KW - children KW - human diseases KW - immunoglobulins KW - intravenous injection KW - nervous system diseases KW - USA KW - man KW - Streptococcaceae KW - Streptococcus KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Lactobacillales KW - Bacilli KW - Firmicutes KW - Bacteria KW - prokaryotes KW - Streptococcaceae KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - bacterium KW - beta-haemolytic streptococci KW - gamma-globulins KW - immune globulins KW - neuropathy KW - neuropsychiatry KW - plasma (blood) KW - post-streptococcal glomerulonephritis KW - United States of America KW - Host Resistance and Immunity (HH600) KW - Non-communicable Human Diseases and Injuries (VV600) KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000) KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006972&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Paediatric HIV-1 infection. AU - Burns, D. N. AU - Mofenson, L. M. JO - Lancet (British edition) JF - Lancet (British edition) Y1 - 1999/// VL - 354 IS - Suppl. 2 SP - 1 EP - 6 SN - 0140-6736 AD - Burns, D. N.: Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510, USA. N1 - Accession Number: 20002005568. Publication Type: Journal Article. Language: English. Number of References: 60 ref. KW - antiviral agents KW - children KW - disease transmission KW - drug therapy KW - HIV infections KW - human diseases KW - maternal transmission KW - pathogenesis KW - prophylaxis KW - Human immunodeficiency virus 1 KW - man KW - human immunodeficiency viruses KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus infections KW - human immunodeficiency virus type 1 KW - mother to child transmission KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005568&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Re-emergence of HIV after stopping therapy. AU - Chun TaeWook AU - Davey, R. T., Jr. AU - Engel, D. AU - Lane, H. C. AU - Fauci, A. S. JO - Nature (London) JF - Nature (London) Y1 - 1999/// VL - 401 IS - 6756 SP - 874 EP - 875 SN - 0028-0836 AD - Chun TaeWook: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20002004819. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health KW - antiviral agents KW - drug therapy KW - HIV infections KW - human diseases KW - human immunodeficiency viruses KW - viraemia KW - man KW - Lentivirus KW - Orthoretrovirinae KW - Retroviridae KW - RNA Reverse Transcribing Viruses KW - viruses KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - chemotherapy KW - human immunodeficiency virus KW - human immunodeficiency virus infections KW - viremia KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) KW - Pesticides and Drugs (General) (HH400) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004819&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Effect of Siamese cassia leaves on the activities of chemical carcinogen metabolizing enzymes and on mammary gland carcinogenesis in the rat. AU - Tepsuwan, A. AU - Kupradinun, P. AU - Kusamran, W. R. JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis Y1 - 1999/// VL - 428 IS - 1/2 SP - 363 EP - 373 SN - 0027-5107 AD - Tepsuwan, A.: Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand. N1 - Accession Number: 20001418143. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 9035-51-2. Subject Subsets: Dairy Science; Human Nutrition; Agroforestry N2 - Male Wistar rats were fed AIN-76 semipurified diet or diet containing 5% ground lyophilized Siamese cassia (Cassia siamea) leaves for 2 weeks before sacrifice. Hepatic S9 fractions were prepared and assayed for the level of cytochrome P450 (P450), the activities of monooxygenase, i.e., aniline hydroxylase (ANH), aminopyrine-N-demethylase (AMD) as well as the capacity to metabolically activate the mutagenicities of aflatoxin B1 (AFB1) and benzo(a)pyrene (B(a)P). In addition, the activities of detoxificating enzymes such as glutathione-S-transferase (GST) and UDP-glucuronyltransferase (UGT) were also measured. It was found that feeding of Siamese cassia leaves significantly reduced the activities of hepatic ANH and AMD as well as the capacity to activate the mutagenicity of AFB1 towards Salmonella typhimurium TA100, being 31, 73 and 41% of control group, respectively. It also slightly decreased, but not significantly, the capacity to activate the mutagenicity of B(a)P towards S. typhimurium YG1029. On the other hand, however, the activities of both GST and UGT were markedly increased in those animals, being 250 and 220% of control animals. The anticarcinogenic potential of Siamese cassia leaves was also investigated in female Sprague Dawley rats treated with 9.10-dimethyl-1.2-benzanthracene (DMBA). The animals were fed control diet or diet containing ground lyophilized Siamese cassia leaves 2 weeks prior to and 1 week after intragastrically administration of DMBA, and then they were placed on a pellet diet for additional 25 weeks. Interestingly, it was found that feeding of diet containing 2.5 and 4% Siamese cassia leaves resulted in a significant decrease in the multiplicity of mammary gland tumors as well as a slight delay of the onset of tumor development. The incidence of tumors in the group fed 4% Siamese cassia leaves, but not in the 2.5% group, was lowered, although not significantly, than that of control group. The results in the present study therefore demonstrated that Siamese cassia leaves possess phase II enzyme inducing property as well as the ability to reduce some phase I enzyme activities in rat liver. This Thai vegetable also exhibit cancer chemopreventive potential, at least against DMBA-induced mammary gland carcinogenesis which may be partly due to phase II inducing capacity as well as phase I inhibitory activity. KW - aflatoxins KW - animal models KW - carcinogenesis KW - cytochrome P-450 KW - diets KW - enzyme activity KW - feeding KW - inhibition KW - liver KW - mammary glands KW - mycotoxins KW - neoplasms KW - Thailand KW - Cassia KW - rats KW - Salmonella KW - Salmonella typhimurium KW - Senna siamea KW - Caesalpinioideae KW - Fabaceae KW - Fabales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - animals KW - Enterobacteriaceae KW - Enterobacteriales KW - Gammaproteobacteria KW - Proteobacteria KW - Bacteria KW - prokaryotes KW - Salmonella enterica subsp. enterica KW - Salmonella enterica KW - Salmonella KW - Senna (genus) KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - bacterium KW - cancers KW - fungal toxins KW - leave KW - Animal Models of Human Nutrition (VV140) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001418143&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Progress in cancer chemoprevention. AU - Kelloff, G. J. AU - Crowell, J. A. AU - Steele, V. E. AU - Lubet, R. A. AU - Boone, C. W. AU - Malone, W. A. AU - Hawk, E. T. AU - Lieberman, R. AU - Lawrence, J. A. AU - Kopelovich, L. AU - Iqbal Ali AU - Viner, J. L. AU - Sigman, C. C. A2 - Bradlow, H. L. A2 - Fishman, J. A2 - Osborne, M. P. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1999/// VL - 889 SP - 1 EP - 13 CY - New York; USA PB - New York Academy of Sciences SN - 0077-8923 SN - 1573311987\1573311995 AD - Kelloff, G. J.: National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20013018040. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 38 ref. Registry Number: 7440-70-2, 7782-49-2, 1406-18-4. Subject Subsets: Human Nutrition; Agricultural Biotechnology N2 - More than 40 promising agents and agent combinations are being evaluated clinically as chemopreventive drugs for major cancer targets. A few have been in vanguard, large-scale intervention trials - for example, the studies of tamoxifen and fenretinide in breast, 13-cis-retinoic acid in head and neck, vitamin E and selenium in prostate, and calcium in colon. These and other agents are currently in phase II chemoprevention trials to establish the scope of their chemopreventive efficacy and to develop intermediate biomarkers as surrogate end points for cancer incidence in future studies. In this group are fenretinide, 2-difluoromethylornithine, and oltipraz. Nonsteroidal anti-inflammatories (NSAID) are also in this group because of their colon cancer chemopreventive effects in clinical intervention, epidemiological, and animal studies. New agents are continually considered for development as chemopreventive drugs. Preventive strategies with antiandrogens are evolving for prostate cancer. Anti-inflammatories that selectively inhibit inducible cyclooxygenase (COX)-2 are being investigated in colon as alternatives to the NSAID, which inhibit both COX-1 and COX-2 and derive their toxicity from COX-1 inhibition. Newer retinoids with reduced toxicity, increased efficacy, or both (e.g., 9-cis-retinoic aclecular) and genomic biomarkers that can be used for risk assessment and as surrogate end points in clinical studies, (2) animal carcinogenesis models that mimic human disease (including transgenic and gene knockout mice), and (3) novel agent treatment regimens (e.g., local delivery to cancer targets, agent combinations, and pharmacodynamically guided dosing). KW - calcium KW - carcinogenesis KW - colon KW - epidemiology KW - genetically engineered organisms KW - human diseases KW - inhibition KW - models KW - neoplasms KW - prevention KW - prostate KW - retinoids KW - selenium KW - toxicity KW - transgenic animals KW - vitamin E KW - man KW - mice KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Muridae KW - rodents KW - cancers KW - genetically engineered animals KW - genetically modified animals KW - genetically modified organisms KW - GEOs KW - GMOs KW - vitamin A compounds KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013018040&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Season-specific correlation between dietary intake of fruits and vegetables and levels of serum biomarkers among Chinese Tin miners at high risk for lung cancer. AU - Forman, M. R. AU - Zhang, J. AU - Gunter, E. AU - Yao, S. X. AU - Gross, M. AU - Qiao, Y. L. AU - Graubard, B. I. AU - Taylor, P. R. AU - Keith, S. AU - Maher, M. A2 - Bradlow, H. L. A2 - Fishman, J. A2 - Osborne, M. P. JO - Annals of the New York Academy of Sciences JF - Annals of the New York Academy of Sciences Y1 - 1999/// VL - 889 SP - 230 EP - 239 CY - New York; USA PB - New York Academy of Sciences SN - 0077-8923 SN - 1573311987\1573311995 AD - Forman, M. R.: Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, 6006 Executive Boulevard, Suite 321, MSC 7058, Bethesda, MD 20892-7058, USA. N1 - Accession Number: 20013018090. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 35 ref. Registry Number: 7440-31-5. Subject Subsets: Tropical Diseases; Human Nutrition KW - diets KW - fruits KW - intake KW - lung cancer KW - lungs KW - miners KW - neoplasms KW - occupational hazards KW - tin KW - vegetables KW - China KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developing Countries KW - East Asia KW - Asia KW - cancers KW - People's Republic of China KW - vegetable crops KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) KW - Human Nutrition (General) (VV100) KW - Diet Studies (VV110) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013018090&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR T1 - Detection of Alexandrium tamarensis by rapid PCR analysis. AU - Wakabayashi, T. AU - Messing, A. AU - Brenner, M. JO - BioTechniques (Euro Edition) JF - BioTechniques (Euro Edition) Y1 - 1999/// IS - 34 SP - 48 EP - 52 SN - 0736-6205 AD - Wakabayashi, T.: National Institute of Neurological Disorders and Stroke, NIH Bethesda, MD, USA. N1 - Accession Number: 19992212349. Publication Type: Journal Article. Language: English. Number of References: 20 ref. N2 - Alexandrium tamarensis is a toxigenic dinoflagellate found in coastal waters worldwide. A critical factor in alleviating the health and economic threats posed by this species is the development of a rapid and reliable method for detection. This study stream-lined a labour- and resource-intensive protocol for the isolation of A. tamarensis ribosomal DNA (rDNA). Subcultures of A. tamarensis were established in water samples from several coastal Atlantic sites. A commercial DNA isolation kit protocol for cultured cells was used for isolation of the dinoflagellate DNA. Samples were amplified by PCR using primers specific for a 700-bp sequence of A. tamarensis rDNA. It was determined that this method facilitated the detection of 10-4 ng/µL of A. tamarensis DNA. Furthermore, the kit enabled A. tamarensis to be isolated from the water sources with little signal degradation. This is a valuable technique for the rapid detection of A. tamarensis, even before cell numbers are large enough for morphological identification. KW - aquatic plants KW - detection KW - phytoplankton KW - sea water KW - toxicology KW - Alexandrium KW - algae KW - Gonyaulacales KW - plants KW - plants KW - aquatic plants KW - aquatic organisms KW - eukaryotes KW - Gonyaulacaceae KW - Gonyaulacales KW - Dinophyceae KW - Dinoflagellida KW - Sarcomastigophora KW - Protozoa KW - invertebrates KW - animals KW - dinoflagellates KW - Goniodomataceae KW - seawater KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000) KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992212349&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Cancer in Thailand. Vol. II, 1992-1994. AU - Deerasamee, S. AU - Martin, N. AU - Sontipong, S. AU - Sriamporn, S. AU - Sriplung, H. AU - Srivatanakul, P. AU - Vatanasapt, V. AU - Parkin, D. M. AU - Ferlay, J. T2 - IARC Technical Report JO - IARC Technical Report JF - IARC Technical Report Y1 - 1999/// IS - 34 SP - J + 135 EP - J + 135 CY - Geneva; Switzerland PB - World Health Organization SN - 928322406X AD - Deerasamee, S.: Ministry of Public Health, National Cancer Institute, Department of Medical Services, Thailand. N1 - Accession Number: 20002016062. Publication Type: Annual report. Language: English. Number of References: 6 pp. of ref. Subject Subsets: Tropical Diseases N2 - This publication presents data on cancer incidence collected from 5 population-based cancer registries in Thailand (Bangkok and its vicinity, Chiang Mai Province, Khon Kaen Province, Lampang Province and Songkhla Province) and comparison is made with data on cancer incidence from other parts of the world. It discusses the importance of different risk factors, with particular emphasis on studies carried out in populations in Thailand. KW - epidemiology KW - human diseases KW - incidence KW - neoplasms KW - Thailand KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - ASEAN Countries KW - Developing Countries KW - South East Asia KW - Asia KW - cancers KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016062&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Antioxidants and the prevention of cancer. AU - Greenwald, P. AU - McDonald, S. S. A2 - Basu, T.K. A2 - Temple, N.J. A2 - Garg, M.L. T2 - Antioxidants in human health and disease. Y1 - 1999/// CY - Wallingford; UK PB - CABI Publishing SN - 0851993346 AD - Greenwald, P.: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA. N1 - Accession Number: 19991409884. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 5 pp. of ref. Registry Number: 50-81-7, 7235-40-7, 476-66-4, 7782-49-2. Subject Subsets: Human Nutrition N2 - This chapter examines the role of antioxidants in cancer prevention. Areas of focus include: Micronutrients - β-carotene, vitamin E, ascorbic acid, selenium; phytochemicals - phenolic compounds, tea extracts, green tea polyphenols, curcumin, ellagic acid; carotenoids; and large-scale, randomized intervention trials. KW - antioxidants KW - ascorbic acid KW - beta-carotene KW - carotenoids KW - ellagic acid KW - neoplasms KW - phytochemicals KW - polyphenols KW - prevention KW - selenium KW - tea KW - trace elements KW - vitamins KW - Camellia sinensis KW - man KW - Camellia KW - Theaceae KW - Theales KW - dicotyledons KW - angiosperms KW - Spermatophyta KW - plants KW - eukaryotes KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - cancers KW - microelements KW - tetraterpenoids KW - vitamin C KW - Crop Produce (QQ050) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409884&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. AU - Ries, L. A. G. AU - Smith, M. A. AU - Gurney, J. G. AU - Linet, M. AU - Tamra, T. AU - Young, J. L. AU - Bunin, G. R. A2 - Ries, L. A. G. A2 - Smith, M. A. A2 - Gurney, J. G. A2 - Linet, M. A2 - Tamra, T. A2 - Young, J. L. A2 - Bunin, G. R. T2 - Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995 T3 - NIH Pub. No. 99-4649 Y1 - 1999/// CY - Bethesda; USA PB - National Cancer Institute (NCI) AD - Ries, L. A. G.: Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd., Executive Plaza North, Room 343J, Bethesda, MD 20892-7352, USA. N1 - Accession Number: 20083240999. Publication Type: Book. Note: NIH Pub. No. 99-4649 Language: English. Subject Subsets: Public Health N2 - This monograph assembles the most detailed information available on the incidence of childhood cancer in the USA. These population-based data is important in furthering the understanding of the variations in childhood cancer by histological type and primary site and the variations in incidence of these cancers over time. The monograph provides information about childhood cancer incidence and mortality rates that can enhance the level of public discourse, and it can be used in planning research that will help us to better understand these cancers and their causes. The monograph details incidence for 1975-1995 and survival by International Classification of Childhood Cancer (ICCC) group and by patient demographic characteristics. For each of the major ICCC groups, information on known risk factors is also presented. The monograph emphasizes not only ICCC group but also age as important factors in childhood cancer incidence. The cancers discussed include those occurring in children younger than 15 years of age as well as those occurring in adolescents up to age 19 years. The monograph highlights the importance of the SEER Program as a national resource. KW - adolescents KW - children KW - disease incidence KW - epidemiology KW - histology KW - histopathology KW - human diseases KW - neoplasms KW - risk factors KW - USA KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - cancers KW - teenagers KW - United States of America KW - Non-communicable Human Diseases and Injuries (VV600) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083240999&site=ehost-live&scope=site UR - http://seer.cancer.gov/publications/childhood/foreword.pdf DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Lipid mediators in a paradigm shift: balance between ω-6 and ω-3. AU - Lands, W. E. M. A2 - Sim, J. S. A2 - Nakai, S. A2 - Guenter, W. T2 - Egg nutrition and biotechnology. Y1 - 1999/// CY - Wallingford; UK PB - CABI Publishing SN - 0851993303 AD - Lands, W. E. M.: National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA. N1 - Accession Number: 20001410893. Publication Type: Book chapter. Language: English. Number of References: 6 pp. of ref. Subject Subsets: Human Nutrition N2 - There are two contrasting hypotheses regarding cardiovascular mortality: one concerns excessive molecules circulating in the plasma and the other concerns excessive inflammatory, proliferative signals in the vascular wall. Some lipids mediate cellular actions, whereas other lipids serve as surrogate indices of pathology. Successful intervention in decreasing myocardial infarctions by low-dose aspirin suggests that a prostaglandin-related n-6 eicosanoid (thromboxane A2) mediates fatal thrombotic events. Also, successful intervention in decreasing cardiovascular death by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors suggests that an isoprenoid derivative (prenylated oncogene?) mediates inflammatory/proliferative processes in atherosclerotic plaques. Inflammatory, proliferative events are also mediated by excessive formation and function of n-6 eicosanoids associated with release of cytokines, platelet-activating factor (PAF) and PAF mimics, as well as reactive oxygen (ROS), all of which cause further pathophysiology. In this context, two hydrolytic enzymes carried on high-density lipoproteins (HDLs), PAF-acetylhydrolase and paraoxonase, diminish the pathological effects of PAF mimics carried on oxidized low-density lipoproteins (LDLs). It was reported 25 years ago that the formation of n-6 eicosanoids is diminished competitively by the δ-3 type of highly unsaturated fatty acid (HUFA) released from tissue phospholipids when 20:4n-6 is released. In this way, dietary n-3 fats diminish n-6 eicosanoid-mediated risks of thrombosis, leucocyte adhesion, vascular wall inflammation and myocardial arrhythmia. Future progress may come from carefully interpreting known metabolic patterns that maintain HUFA precursors of n-6 eicosanoids in tissue lipids. Clinical targets for healthy subjects are 20-26 kg/m² for body mass index 70-110 mg/dl for blood glucose, less than 200 mg/dl for cholesterol, and it seems likely that another useful clinical target will be more than 45% for the proportion of n-3 HUFA in plasma phospholipid HUFA. KW - cardiovascular diseases KW - polyenoic fatty acids KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - polyunsaturated fatty acids KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410893&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Laboratory maintenance of phlebotomine sand flies. AU - Modi, G. B. AU - Rowton, E. D. A2 - Maramorosch, K. A2 - Mahmood, F. T2 - Maintenance of human, animal, and plant pathogen vectors. Y1 - 1999/// CY - Enfield, NH; USA PB - Science Publishers, Inc. SN - 1578080495 AD - Modi, G. B.: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. N1 - Accession Number: 20000507910. Publication Type: Book chapter. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology N2 - A method for laboratory rearing and maintenance of phlebotomine sandflies is described. The method has been used for the past several years, and currently, 11 laboratory colonies of sandflies (of the species Phlebotomus argentipes, P. duboscqi, P. sergenti, P. papatasi, Lutzomyia longipalpis and Sergentomyia schwetzi) are being maintained by this method at the Walter Reed Army Institute of Research, Washington, DC, USA. Briefly, the method consists of holding the adult flies in 31-cm² Lexan cages on apple slices as a source of sugar. The females are fed on anaesthetized golden hamsters for their blood meal and a day after the blood meal, they are transferred into polycarbonate (containing a 2-cm layer of plaster of paris at the bottom) containers for oviposition. The females are fed on 50% karo until the oviposition is complete. The larvae are fed on an aged mixture of rabbit faeces and rabbit chow. The entire life cycle of sandflies, including the blood feeding, holding the gravid females and immature stages takes place inside the reach-in incubators at 26.5-27.0°C and 80-95% RH. A brief methodology is also given for collection of the sandflies from their natural habitats and their transportation to the laboratory for initiating colonies of these flies. KW - oviposition KW - rearing techniques KW - reviews KW - techniques KW - Diptera KW - golden hamsters KW - Lutzomyia KW - Lutzomyia longipalpis KW - Phlebotominae KW - Phlebotomus KW - Phlebotomus argentipes KW - Phlebotomus duboscqi KW - Phlebotomus papatasi KW - Phlebotomus sergenti KW - Psychodidae KW - rabbits KW - Sergentomyia KW - Sergentomyia schwetzi KW - insects KW - Hexapoda KW - arthropods KW - invertebrates KW - animals KW - eukaryotes KW - Mesocricetus KW - Cricetinae KW - Muridae KW - rodents KW - mammals KW - vertebrates KW - Chordata KW - Phlebotominae KW - Psychodidae KW - Diptera KW - Lutzomyia KW - Phlebotomus KW - Leporidae KW - Lagomorpha KW - Sergentomyia KW - Other Invertebrate Culture (Not Aquaculture) (LL030) KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000) KW - Techniques and Methodology (ZZ900) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000507910&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Reduction of the incidence of metachronous adenomas of the large bowel by means of antioxidants: a double blind randomized trial. AU - Bonelli, L. AU - Camoriano, A. AU - Ravelli, P. AU - Missale, G. AU - Bruzzi, P. AU - Aste, H. A2 - Kumpulainen, J. T. A2 - Salonen, J. T. T2 - Natural antioxidants and anticarcinogens in nutrition, health and disease. Y1 - 1999/// CY - Cambridge; UK PB - Royal Society of Chemistry SN - 085404793X AD - Bonelli, L.: Unit of Clinical Epidemiology and Trial, National Cancer Institute of Genova, Italy. N1 - Accession Number: 19991414766. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 28 ref. Registry Number: 50-81-7, 68-26-8, 7782-49-2, 1406-18-4, 7440-66-6. Subject Subsets: Human Nutrition N2 - This study evaluated: the efficacy of a combination of selenium, zinc and antioxidant vitamins in reducing the incidence of metachronous adenomas of the large bowel after endoscopic polypectomy; the compliance of the patients to treatment and follow-up procedures; and the side effects associated with the treatment. KW - antioxidants KW - ascorbic acid KW - colon KW - colorectal cancer KW - neoplasms KW - retinol KW - selenium KW - trace elements KW - vitamin E KW - vitamins KW - zinc KW - Italy KW - man KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Developed Countries KW - European Union Countries KW - Mediterranean Region KW - OECD Countries KW - Southern Europe KW - Europe KW - axerophthol KW - cancers KW - microelements KW - vitamin A KW - vitamin A alcohol KW - vitamin A1 KW - vitamin C KW - Physiology of Human Nutrition (VV120) KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414766&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - Natural product drug discovery and development. The United States National Cancer Institute role. AU - Cragg, G. M. AU - Boyd, M. R. AU - Khanna, R. AU - Newman, D. J. AU - Sausville, E. A. A2 - Romeo, J. T. T2 - Phytochemicals in human health protection, nutrition, and plant defense. Y1 - 1999/// CY - New York; USA PB - Kluwer Academic/Plenum Publishers SN - 0306462036 AD - Cragg, G. M.: Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA. N1 - Accession Number: 20000309882. Publication Type: Book chapter. Language: English. Number of References: 41 ref. Subject Subsets: Horticultural Science KW - drugs KW - medicinal plants KW - natural products KW - research KW - USA KW - APEC countries KW - Developed Countries KW - North America KW - America KW - OECD Countries KW - drug plants KW - medicinal herbs KW - medicines KW - National Cancer Institute KW - officinal plants KW - pharmaceuticals KW - studies KW - United States of America KW - Non-food/Non-feed Plant Products (SS200) KW - Pharmacology (VV730) (New March 2000) KW - Research (AA500) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000309882&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - GEN T1 - A nutrient-permeable channel on the intraerythrocytic malaria parasite. AU - Desai, S. A. A2 - Bock, G. R. A2 - Cardew, G. T2 - Transport and trafficking in the malaria-infected erythrocyte. Proceedings of a Symposium held at the Novartis Foundation, London, UK, 26-28 January 1999 T3 - Novartis Foundation Symposium 226 Y1 - 1999/// CY - Chichester; UK PB - John Wiley & Sons Ltd SN - 0471998931 AD - Desai, S. A.: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Building 4, Room 126, 9000, Rockville Pike, Bethesda, MD 20814, USA. N1 - Accession Number: 20003010172. Publication Type: Book chapter; Conference paper. Note: Novartis Foundation Symposium 226 Language: English. Number of References: 11 ref. Subject Subsets: Tropical Diseases; Protozoology N2 - The intraerythrocytic malaria parasite Plasmodium falciparum faces at least 3 membranous barriers to the acquisition of nutrients from serum: the human erythrocyte membrane, the parasitophorous vacuole membrane (PVM) and the parasite plasma membrane. The PVM is a specialized parasite-derived membrane that separates the parasite from erythrocyte cytosol. The patch clamp method was used to identify and characterize the main transport pathway on the PVM. Gigaohm seals, formed on mature freed trophozoites, revealed a 140 pS channel permeable to both cations and anions on the PVM. This channel is present at high density, is open more than 95% of the time at the PVM resting potential, and is capable of transporting amino acids and monosaccharides across the PVM. This nutrient-permeable channel was then reconstituted into artificial lipid bilayers, where it exhibited similar slope conductances, gating, voltage dependence and permeability to soluble nutrients. In bilayers, the channel was found to have non-saturating kinetics and an effective pore diameter of 23 Å. The results suggest a high capacity molecular sieve that allows the parasite to acquire soluble nutrients from the erythrocyte cytosol. KW - amino acids KW - anions KW - biochemical transport KW - carbohydrates KW - cations KW - cell membranes KW - conferences KW - cytosol KW - erythrocytes KW - host parasite relationships KW - malaria KW - nutrients KW - parasitophorous vacuoles KW - permeability KW - plasma membranes KW - trophozoites KW - man KW - Plasmodium falciparum KW - Homo KW - Hominidae KW - Primates KW - mammals KW - vertebrates KW - Chordata KW - animals KW - eukaryotes KW - Plasmodium KW - Plasmodiidae KW - Haemospororida KW - Apicomplexa KW - Protozoa KW - invertebrates KW - blood red cells KW - cell membrane KW - parasite host relationships KW - plasmalemma KW - red blood cells KW - saccharides KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000) KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000) UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003010172&site=ehost-live&scope=site DP - EBSCOhost DB - lhh ER - TY - JOUR ID - 2011-16075-001 AN - 2011-16075-001 AU - Martin, John Rogers T1 - Reminiscence and gestalt theory. JF - Psychological Monographs JO - Psychological Monographs JA - Psychol Monogr Y1 - 1940/// VL - 52 IS - 4 SP - i EP - 37 CY - US PB - American Psychological Association SN - 0096-9753 AD - Martin, John Rogers N1 - Accession Number: 2011-16075-001. Other Journal Title: Psychological Monographs: General and Applied; The Psychological Monographs; The Psychological Review: Monograph Supplements. Partial author list: First Author & Affiliation: Martin, John Rogers; Pennsylvania Industrial School, Huntingdon, PA, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gestalt Psychology; Intelligence; Juvenile Delinquency; Memory; Reminiscence. Minor Descriptor: Stress. Classification: Cognitive Processes (2340); Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Revised Stanford- Binet Scale for Measuring Intelligence, Form L. Methodology: Empirical Study; Quantitative Study. References Available: Y. Issue Publication Date: 1940. AB - By definition, reminiscence appears after the learning process and at the time of the second recall. The first recall must result in an incomplete reproduction of the material if new, i.e., reminiscent, material is to appear in the second recall. If this hypothesis is true, the available reminiscent material having the greatest stress at the time of the second recall should show the greatest reminiscence, since its stress will give relatively greater strength to the tension set up by the second recall. In accordance with the earlier assumptions and the indicated relationship between tension and organization with the passage of time, the following should be expected if the hypothesis of this experiment is supported. Two hundred young men selected from those attending an industrial school for delinquents served as subjects. The entire school population had previously been given the Revised Stanford- Binet Scale for Measuring Intelligence, Form L, and the subjects for this experiment were selected at random from those obtaining an intelligence quotient of 80 or above. The subjects were chosen from those boys who were living in single cells, i.e., those boys who did not have cell mates. This was done to control as much as possible the probability of discussion of the experiment which would act as practice facilitating later recall. It is the purpose of this section to demonstrate the general application of the theory of reminiscence developed in this paper, supported by the gestalt theory of memory traces, to the major conditions reported in the literature as conditioning the appearance of reminiscence. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - reminiscence KW - gestalt theory KW - memory KW - intelligence KW - stress KW - juvenile delinquents KW - 1940 KW - Gestalt Psychology KW - Intelligence KW - Juvenile Delinquency KW - Memory KW - Reminiscence KW - Stress KW - 1940 DO - 10.1037/h0093575 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16075-001&site=ehost-live&scope=site UR - martin.rogers@nih.gov DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1948-04673-001 AN - 1948-04673-001 AU - Blum, Harold F. T1 - The importance of the individual in human evolution. JF - Scientific Monthly, New York JO - Scientific Monthly, New York Y1 - 1948/// VL - 67 SP - 115 EP - 118 N1 - Accession Number: 1948-04673-001. PMID: 18884650 Partial author list: First Author & Affiliation: Blum, Harold F.; National Cancer Institute, New York. Release Date: 19481101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: General Psychology (2100). Page Count: 4. Issue Publication Date: 1948. AB - Discussion and illustration bear on these points, that 'genetically speaking, the individual as such is of no great evolutionary importance unless he be the bearer of a mutant gene, and even then the importance of the mutation may not manifest itself in the population as a whole for generations. In cultural evolution, on the other hand, the individual would seem to hold a position of great importance. The mechanisms in the two instances are so different that they can hardly be discussed in the same terms.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - INDIVIDUAL KW - IN CULTURAL VS. BIOLOGICAL EVOLUTION KW - EVOLUTION KW - BIOLOGICAL VS. CULTURAL KW - CULTURE KW - VS. HEREDITY KW - GENERAL KW - 1948 KW - No terms assigned KW - 1948 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1948-04673-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1950-03123-001 AN - 1950-03123-001 AU - Birren, James E. AU - Shock, Nathan W. T1 - Age changes in rate and level of visual dark adaptations. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1949/// VL - 4 SP - 330 EP - 331 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1950-03123-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Baltimore, Md. Other Publishers: Oxford University Press. Release Date: 19500601. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 2. Issue Publication Date: 1949. AB - Source contains an abstract only. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - DARK ADAPTATION KW - AGE CHANGES KW - AGE KW - CHANGES KW - MATURITY & OLD AGE KW - 1949 KW - No terms assigned KW - 1949 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-03123-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1951-02139-001 AN - 1951-02139-001 AU - Cornfield, Jerome AU - Mantel, Nathan T1 - Some new aspects of the application of maximum likelihood to the calculation of the dosage response curve. JF - Journal of the American Statistical Association JO - Journal of the American Statistical Association JA - J Am Stat Assoc Y1 - 1950/// VL - 45 SP - 181 EP - 210 CY - US PB - American Statistical Association SN - 0162-1459 SN - 1537-274X N1 - Accession Number: 1951-02139-001. Other Journal Title: Publications of the American Statistical Association; Quarterly Publication of the American Statistical Association. Partial author list: First Author & Affiliation: Cornfield, Jerome; National Cancer Institute, Bethesda, Md. Release Date: 19510401. Correction Date: 20130513. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 30. Issue Publication Date: 1950. AB - The estimation of the parameters of dosage response curves by the standard probit method is an interative process beginning with approximations to the parameters and using one or more cycles of computations to 'improve' these estimates until they converge. A table and method for computing the maximum likelihood solution which converges more rapidly than the standard probit method is presented. A procedure for obtaining more accurate initial approximations is given, and the problem of the bias of the maximum likelihood estimates in small samples is considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - CURVE KW - DOSAGE RESPONSE KW - PARAMETERS KW - STATISTICS KW - 1950 KW - No terms assigned KW - 1950 DO - 10.2307/2280677 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-02139-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1951-02974-001 AN - 1951-02974-001 AU - Birren, James E. AU - Botwinick, Jack T1 - Effects of age and senile psychoses upon speed of writing digits and words. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1950/// VL - 5 SP - 383 EP - 384 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1951-02974-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19510501. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 2. Issue Publication Date: 1950. AB - Source contains an abstract only. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PSYCHOSIS KW - SENILE KW - & WRITING SPEED KW - OLD AGE KW - HANDWRITING KW - SPEED KW - & OLD AGE KW - MATURITY & OLD AGE KW - 1950 KW - No terms assigned KW - 1950 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-02974-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1950-06167-001 AN - 1950-06167-001 AU - Birren, James E. AU - Bick, Malcolm W. AU - Yiengst, Marvin T1 - The relation of structural changes of the eye and vitamin A to elevation of the light threshold in later life. JF - Journal of Experimental Psychology JO - Journal of Experimental Psychology JA - J Exp Psychol Y1 - 1950/04// VL - 40 IS - 2 SP - 260 EP - 266 CY - US PB - American Psychological Association SN - 0022-1015 N1 - Accession Number: 1950-06167-001. PMID: 15415524 Other Journal Title: Journal of Experimental Psychology: General. Partial author list: First Author & Affiliation: Birren, James E.; National Institutes of Health, Bethesda, Md. Other Publishers: Psychological Review Company. Release Date: 19501201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Visual Thresholds; Vitamins. Minor Descriptor: Eye (Anatomy); Retina. Classification: Visual Perception (2323). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1950. Copyright Statement: American Psychological Association. 1950. AB - 'Studies were made of the relation of the minimum light threshold to changes in the retina and transmission system of the eye. A total of 109 male subjects, aged 40-83, was observed… . In addition to a significant age decline in visual sensitivity as revealed by the light threshold, there was observed a high prevalence of changes in the retina, macula, and transmission system of the older eye. The light threshold of the older subjects was correlated with the presence of retinal degeneration… . Results of vitamin A determinations indicated a lack of age change in serum vitamin A and a lack of correlation between the age change in light threshold and serum vitamin A.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - structural changes KW - eye KW - vitamin A KW - light threshold KW - retina KW - 1950 KW - Visual Thresholds KW - Vitamins KW - Eye (Anatomy) KW - Retina KW - 1950 DO - 10.1037/h0057891 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-06167-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1951-06099-001 AN - 1951-06099-001 AU - Shock, Nathan W. AU - Wehrwein, Annabel T1 - Government-conducted research in gerontology. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1951/// VL - 6 SP - 68 EP - 70 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1951-06099-001. PMID: 14803703 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Shock, Nathan W.; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19510901. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 3. Issue Publication Date: 1951. AB - 'A total of 31 divisions and bureaus was canvassed… ', 17 were conducting research related to gerontology. Studies are underway on aging of materials, animals and man. Economic aspects of aging are included in the activities of several agencies while research on the biological aspects of aging is largely centered in the National Institutes of Health of the Public Health Service. The subject matter as well as the location of the various projects is given. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - OLD AGE KW - RESEARCH KW - GOVERNMENT KW - MATURITY & OLD AGE KW - 1951 KW - No terms assigned KW - 1951 DO - 10.1093/geronj/6.1.68 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-06099-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Shock, Nathan W. T1 - GERONTOLOGY (LATER MATURITY). JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1951/02// VL - 2 IS - 1 M3 - Article SP - 353 PB - Annual Reviews Inc. SN - 00664308 AB - Discusses studies of gerontology. Quantitative measurements of auditory acuity; Increased presbyopia of older people; Changes in the structure of the eye; Motor responses in old age. KW - RESEARCH KW - GERONTOLOGY KW - OLD age KW - OLDER people KW - PSYCHOLOGY N1 - Accession Number: 11290999; Shock, Nathan W. 1; Affiliations: 1: National Heart Institute, National Institutes of Health; Issue Info: 1951, Vol. 2 Issue 1, p353; Thesaurus Term: RESEARCH; Subject Term: GERONTOLOGY; Subject Term: OLD age; Subject Term: OLDER people; Subject Term: PSYCHOLOGY; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 18p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11290999&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 1952-06419-001 AN - 1952-06419-001 AU - Botwinick, Jack AU - Birren, James E. T1 - The measurement of intellectual decline in the senile psychoses. JF - Journal of Consulting Psychology JO - Journal of Consulting Psychology JA - J Consult Psychol Y1 - 1951/04// VL - 15 IS - 2 SP - 145 EP - 150 CY - US PB - American Psychological Association SN - 0095-8891 N1 - Accession Number: 1952-06419-001. PMID: 14841282 Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institutes of Health, Bethesda, Md. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 19521001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Intelligence; Schizophrenia; Senile Psychosis. Minor Descriptor: Test Validity. Classification: Clinical Psychological Testing (2224); Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1951. Copyright Statement: American Psychological Association. 1951. AB - The validity of 3 measures of intellectual deficit in the senile was determined. These measures were the Deterioration Quotient (DQ) of the Wechsler-Bellevue Scale, Copple's Senescent Decline Formula (SDF), and the Efficiency Index (EI) of the Babcock-Levy Scale. 31 patients, 60 to 70 years old, diagnosed as senile psychosis or psychosis with arteriosclerosis, were tested. There were significant differences between patients with senile psychosis and a control group on the basis of EI and SDF scores, but the DQ did not differentiate the 2 groups. EI and SDF seemed to measure different aspects of intellectual decline. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - intellectual decline KW - senile psychoses KW - intellectual deficit KW - psychosis KW - 1951 KW - Cognitive Ability KW - Intelligence KW - Schizophrenia KW - Senile Psychosis KW - Test Validity KW - 1951 DO - 10.1037/h0063318 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1952-06419-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-38642-003 AN - 2013-38642-003 AU - Felix, R. H. T1 - Mental hygiene as public health practice. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1951/10// VL - 21 IS - 4 SP - 707 EP - 716 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-38642-003. PMID: 14885383 Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health, Public Health Service, Federal Security Agency, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hygiene; Mental Health; Pathology; Psychiatry; Public Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 10. Issue Publication Date: Oct, 1951. AB - The conviction that psychiatry can contribute to human welfare by working through public health techniques and agencies, as well as through the other medical channels has gained increased acceptance during the past decade. This increased acceptance has come not only on the part of the clinicians, but also on the part of health administrators and the general public. Today, we find a broad and real interest in psychiatry and an impressive demand for mental hygiene services. We can also see the evolution of a practical philosophical framework upon which mental hygiene programs are being built, and we now have at hand a number of promising public health techniques which have been adapted to mental hygiene needs. However, under any conditions the growth of mental hygiene work will continue. Furthermore, it will always be a movement through which psychiatry will be able to emphasize and demonstrate its basic teachings: that health is a totality of physical, emotional and social well-being. Stressing the positive, rather than the pathological, it aims to help people live more effectively, more productively, more in harmony with themselves and their fellows. These objectives are ambitious and far-reaching, but in his work the psychiatrist has many able and enthusiastic allies in other professions and among the public. Working together, we can be confident that these goals will be attained. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - enthusiastic allies KW - human welfare KW - mental hygiene programs KW - mental hygiene services KW - public health practice KW - pathology KW - 1951 KW - Hygiene KW - Mental Health KW - Pathology KW - Psychiatry KW - Public Health KW - 1951 DO - 10.1111/j.1939-0025.1951.tb00023.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-38642-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Hoffman, Erwin F. T1 - MULTI-DIMENSIONAL CLASSIFICATION AND THE TRANSCRIPTION OF CANCER LITERATURE TO PUNCHED CARDS. JO - American Documentation JF - American Documentation Y1 - 1952/01// VL - 3 IS - 1 M3 - Article SP - 61 EP - 70 SN - 0096946X AB - This article focuses on multi-dimensional classification and the transcription of cancer literature to punched cards. The Documentation Section of the National Cancer Institute was established in October 1948, primarily to provide scientists and physicians working in the field of cancer diagnosis with bibliographic material for immediate and practical use in their respective areas of investigation. The potential value of mechanical punch cards for the handling of scientific information has been demonstrated from time to time as revealed by a review of the literature. KW - DOCUMENTATION KW - INFORMATION services KW - LITERATURE KW - CANCER KW - TRANSCRIPTION factors KW - UNITED States N1 - Accession Number: 16888630; Hoffman, Erwin F. 1; Affiliations: 1: National Cancer Institute Documentation Section Technical Services.; Issue Info: Jan1952, Vol. 3 Issue 1, p61; Thesaurus Term: DOCUMENTATION; Thesaurus Term: INFORMATION services; Subject Term: LITERATURE; Subject Term: CANCER; Subject Term: TRANSCRIPTION factors; Subject: UNITED States; NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 10p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16888630&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 1953-04224-001 AN - 1953-04224-001 AU - Felix, R. H. T1 - The technique of mass approach to the problems of mental health. JF - Neuropsychiatry JO - Neuropsychiatry Y1 - 1952/// VL - 2 SP - 48 EP - 62 N1 - Accession Number: 1953-04224-001. PMID: 12982942 Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health, Washington, D.C. Release Date: 19530601. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 15. Issue Publication Date: 1952. AB - Cooperation of psychiatry with family, church, community and mass media is necessary for effective attack on mental health problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - MENTAL HYGIENE KW - MASS APPROACH KW - CLINICAL PSYCHOLOGY KW - GUIDANCE KW - COUNSELING KW - 1952 KW - No terms assigned KW - 1952 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-04224-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1953-01250-001 AN - 1953-01250-001 AU - Felix, R. H. AU - Kramer, Morton T1 - Research in epidemiology of mental illness. JF - Public Health Reports JO - Public Health Reports JA - Public Health Rep Y1 - 1952/// VL - 67 SP - 152 EP - 160 CY - US PB - U.S. Marine Hospital Service SN - 0033-3549 N1 - Accession Number: 1953-01250-001. PMID: 14900338 Other Journal Title: H.S.M.H.A. Health Reports; Health Services Reports. Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health. Bethesda, Md. Other Publishers: Association of Schools of Public Health; Elsevier Science; Oxford University Press; U. S. Public Health Service; U.S. Dept. of Health, Education, and Welfare, Health Services and Mental Health Administration. Release Date: 19530201. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 9. Issue Publication Date: 1952. AB - Consideration is given to two widely quoted community surveys, Selective Service and Armed Forces data, statistics on patients in mental hospitals, and 5 current projects. 'Our basic knowledge of the distribution of mental illness in the population has distinct limitations… effective research on the community aspects of mental illness must be interdisciplinary… ' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - MENTAL DISORDER KW - EPIDEMIOLOGY KW - OF MENTAL DISORDERS KW - BEHAVIOR DEVIATIONS KW - 1952 KW - No terms assigned KW - 1952 DO - 10.2307/4588020 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-01250-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Clausen, John A. T1 - The American Veteran Back Home. JO - American Sociological Review JF - American Sociological Review Y1 - 1952/04// VL - 17 IS - 2 M3 - Book Review SP - 249 EP - 250 SN - 00031224 AB - Reviews the book "The American Veteran Back Home," by Robert J. Havighurst, Walter H. Eaton, John W. Baughman and Ernest W. Burgess. KW - VETERANS -- United States KW - NONFICTION KW - HAVIGHURST, Robert J. (Robert James), 1900-1991 KW - BURGESS, Ernest W. KW - EATON, Walter H. KW - BAUGHMAN, John W. KW - AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book) N1 - Accession Number: 12770758; Clausen, John A. 1; Affiliations: 1: National Institute of Mental Health U. S. Public Health Service; Issue Info: Apr52, Vol. 17 Issue 2, p249; Subject Term: VETERANS -- United States; Subject Term: NONFICTION; Reviews & Products: AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book); People: HAVIGHURST, Robert J. (Robert James), 1900-1991; People: BURGESS, Ernest W.; People: EATON, Walter H.; People: BAUGHMAN, John W.; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12770758&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - CHAP ID - 1954-01048-008 AN - 1954-01048-008 AU - Bobbitt, Joseph M. AU - Clausen, John A. T1 - Psychotherapy and its public health implications. T2 - Psychotherapy: theory and research. Y1 - 1953/// SP - 171 EP - 201 CY - Oxford, England; New York, NY, US PB - Ronald Press Co. PB - Ronald Press Company N1 - Accession Number: 1954-01048-008. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 19540101. Correction Date: 20151221. Publication Type: Book (0200). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Psychotherapy; Public Health. Minor Descriptor: Interpersonal Interaction; Psychotherapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 31. AB - The major concern in this discussion will be with what can be learned from the psychotherapeutic process that can be useful in helping individuals to achieve desirable or improved interpersonal relationships without resort to individual or even group psychotherapy. The objective is that of indicating some of the kinds of questions that should be asked, the research problems that need solution, and public health implications. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychotherapy KW - public health KW - psychotherapeutic process KW - interpersonal relationships KW - 1953 KW - Psychotherapy KW - Public Health KW - Interpersonal Interaction KW - Psychotherapeutic Processes KW - 1953 DO - 10.1037/10572-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-01048-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-05839-006 AN - 2009-05839-006 AU - Meader, Ralph G. ED - Bush, George P. ED - Hattery, Lowell H. ED - Bush, George P., (Ed) ED - Hattery, Lowell H., (Ed) T1 - Sponsoring organized university research. T2 - Teamwork in research. Y1 - 1953/// SP - 46 EP - 57 CY - Washington, DC, US PB - American University Press N1 - Accession Number: 2009-05839-006. Partial author list: First Author & Affiliation: Meader, Ralph G.; Grants and Fellowship Branch, National Cancer Institute, U. S. Public Health Service, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Colleges; Education; Research and Development. Classification: Research Methods & Experimental Design (2260); Educational Psychology (3500). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. AB - The words 'organization' and 'administration' do not always have happy and respected connotations in the minds of investigators. Organizing and administering scientific research implies that there is something to be organized and administered. Actually, it implies planning and carrying out the selection of appropriate personnel, the selection and formulation of research to be done by the personnel, the selection of the methods to be used, the provision of physical and technical facilities necessary for the problem and the personnel concerned, the interpretation of the data obtained and the publication of new contributions to knowledge. Obviously, the most important of these ingredients is the selection of the appropriate personnel for if you have good investigators, they will have good ideas for research and know or develop adequate and appropriate methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - organized university research KW - research & development KW - 1953 KW - Colleges KW - Education KW - Research and Development KW - 1953 DO - 10.1037/13368-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-05839-012 AN - 2009-05839-012 AU - Siepert, Albert F. ED - Bush, George P. ED - Hattery, Lowell H. ED - Bush, George P., (Ed) ED - Hattery, Lowell H., (Ed) T1 - Auxiliary services as aids to laboratory research. T2 - Teamwork in research. Y1 - 1953/// SP - 104 EP - 125 CY - Washington, DC, US PB - American University Press N1 - Accession Number: 2009-05839-012. Partial author list: First Author & Affiliation: Siepert, Albert F.; National Institutes of Health, U. S. Public Health Service, Federal Security Agency, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Experimentation; Research and Development. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 22. AB - Auxiliary services in a research program embrace all the technical and administrative activities which deal with furnishing men, money, and materials except those under the personal direction of the bench scientist or his immediate staff. The competence of the research staff is the biggest single factor in achieving high calibre research. But the effectiveness of supporting services can often make, or break, the physical and intellectual environment which competent investigators seek for good research. The maintenance of an environment which stimulates good research is a primary goal for any research administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - auxiliary services KW - laboratory research KW - 1953 KW - Experimentation KW - Research and Development KW - 1953 DO - 10.1037/13368-012 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1954-00664-001 AN - 1954-00664-001 AU - Ladimer, Irving T1 - Report of the fifth annual scientific meeting of the Gerontological Society, Inc. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1953/// VL - 8 SP - 94 EP - 103 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1954-00664-001. Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Ladimer, Irving; National Institutes of Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19540101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 10. Issue Publication Date: 1953. AB - This report summarizes the papers presented at the 1952 meetings of the Gerontological Society. The information is organized under seven major categories: population trends and concepts of aging, biology and medicine, psychology, health services, economics and employment, welfare and education, and research—status and prospects. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - GERONTOLOGY KW - SOCIETY MEETING KW - SUMMARY KW - MATURITY & OLD AGE KW - 1953 KW - No terms assigned KW - 1953 DO - 10.1093/geronj/8.1.94 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-00664-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Felix, R. H. AU - Clausen, John A. T1 - The Role of Surveys in Advancing Knowledge in the Field of Mental Health. JO - Public Opinion Quarterly JF - Public Opinion Quarterly Y1 - 1953///Spring53 VL - 17 IS - 1 M3 - Article SP - 61 EP - 70 SN - 0033362X AB - In this article, authors describe components of a national mental health program and ways in which survey data can be useful to those who are charged with directing such programs in the U.S., as of March 1, 1953. In order to establish effective programs, public health administrators need to know about the extent of the problem with which they deal. There are several aspects to this need. The problem includes not only the number of people who are ill, the nature of their illness and the development and financing of services for treatment or for preventive programs, but also orientations that people have towards using these services that are available to them. Surveys can be very helpful in increasing knowledge of all these aspects of the problem. Research workers in the field of public opinion have developed a high degree of skill in defining and in reaching populations and samples of respondents, they have established some variables, which relate to the validity of responses secured in interviews. KW - Public opinion KW - METHODOLOGY KW - Mental health laws KW - Public health administration KW - Mental health services -- Finance KW - Social surveys -- Response rate KW - Social sciences KW - United States N1 - Accession Number: 11929415; Felix, R. H. 1; Clausen, John A. 2; Affiliations: 1: Director of the National Institute of Mental Health of the Public Health Service.; 2: John Clausen is Chief of the Laboratory of Socio-environmental Studies of the same institute.; Issue Info: Spring53, Vol. 17 Issue 1, p61; Thesaurus Term: Public opinion; Thesaurus Term: METHODOLOGY; Subject Term: Mental health laws; Subject Term: Public health administration; Subject Term: Mental health services -- Finance; Subject Term: Social surveys -- Response rate; Subject Term: Social sciences; Subject: United States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11929415&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - AU - Ullmann, Charles A.1 T1 - The Socially Maladjusted. JO - Review of Educational Research JF - Review of Educational Research J1 - Review of Educational Research PY - 1953/12// Y1 - 1953/12// VL - 23 IS - 5 CP - 5 M3 - Article SP - 432 EP - 452 SN - 00346543 AB - The article presents a review of several studies on socially maladjusted children. The term socially maladjusted is used in the study to refer both disorders in which emotional or personal aspects are prominent and disorders which involve interactive relationships. A study conducted by Murphy, Shirley and Witmer have pointed out that court statistics are wholly inadequate as a measure of the amount of youthful illegal behavior in the community. A number of studies have been devised to analyze the process by which maladjustment is recognize. The may be reviewed from the standpoint of factors associated with the rater and aspects of social performance. Studies of the role of teachers in the identification of problem behavior have been relatively numerous, although frequently only exploratory and fact-finding in character. The influence of experience or proved competence as a teacher on whether a given behavior is regarded as problem behavior may be inferred from studies by Jones and Slobetz. KW - Problem children KW - Behavior disorders in children KW - Problem children -- Education KW - Problem youth KW - Emotional problems of children KW - Social problems KW - Behavior KW - Children -- Attitudes KW - Psychology N1 - Accession Number: 19158783; Authors: Ullmann, Charles A. 1; Affiliations: 1: National Institute of Mental Health, United States Public Health Service, Bethesda, Maryland; Subject: Problem children; Subject: Behavior disorders in children; Subject: Problem children -- Education; Subject: Problem youth; Subject: Emotional problems of children; Subject: Social problems; Subject: Behavior; Subject: Children -- Attitudes; Subject: Psychology; Number of Pages: 21p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=19158783&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - JOUR AU - Hirsch, Herbert M. T1 - Environmental Factors Influencing the Differentiation of Protoperithecia and their Relation to Tyrosinase and Melanin Formation in Neurospora crassa. JO - Physiologia Plantarum JF - Physiologia Plantarum Y1 - 1954/01// VL - 7 IS - 1 M3 - Article SP - 72 EP - 97 PB - Wiley-Blackwell SN - 00319317 AB - The relation of environment to the differentiation of protoperithecia and two closely allied phenomena, tyrosinase and melanin formation, has been studied in Neurospora crassa. A temperature of 25° C is optimal as regards the formation of protoperithecia while a temperature of 35° inhibits both the formation of protoperithecia and fruitbodies. Increasing amounts of nitrogen, both organic and inorganic, depress and eventually suppress protoperithecia formation specifically; protoperithecia formed at intermediate concentrations of nitrogen appear unpigmented and are largely or wholly nonfunctional, the latter depending in a secondary way on the carbon/nitrogen ratio of the medium on which growth has taken place. The pigment present in the protoperithecia has been found to be melanic in nature: it is produced to a considerable extent only under conditions permitting the formation of functional protoperithecia. Mycelia grown under conditions permitting optimal protoperithecia formation show strong tyrosinase activity which makes its appearance concomitant with or slightly precedes protoperithecial formation; the greatest increase in rate of protoperithecia production coincides with maximal tyrosinase activity of the mycelium. Tyrosinase and melanin are low or absent in mycelia growth at 35°. Mycelia in which protoperithecia formation bas been completely suppressed through the addition of organic nitrogen show very little tyrosinase activity after 7 days' growth and tyrosine is oxidized only to a red pigment; after 14 days a strong tyrosinase can be demonstrated which rapidly oxidizes tyrosine to melanin, but during actual growth only a very small amount of melanin deposition takes place. This inhibition is not due lo the presence of sulfur-containing substances. The possible significance of these findings is discussed. By appropriate changes in the relative and absolute amounts of carbon and nitrogen different stages in the sexual cycle of the organism can be affected, but any condition which prevents the exhaustion of nitrate (and possibly nitrogen in general) always affects in a deleterious manner both the number and normal functioning of the protoperithecia formed. The processes of fertilization and fruit formation, on the other hand, are not greatly affected by the presence of nitrate. Use of tyrosinase inhibitors suppresses the formation of protoperithecia and melanin more or less completely; some other enzyme inhibitors used do not show the same effect and apparently have another site of action. The question of whether tyrosine metabolism has a causal relation to the differentiation and normal functioning of protoperithecia, or whether tyrosinase and melanin are invariable, though accidental, concomitants of protoperithecial formation is discussed. [ABSTRACT FROM AUTHOR] AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - Nitrogen KW - Enzyme inhibitors KW - Cell differentiation KW - Melanins KW - Melanocytes KW - Amino acids KW - Neurospora crassa N1 - Accession Number: 15770136; Hirsch, Herbert M. 1; Affiliations: 1: U.S. Public Health Service Research Fellow of the National Institutes of Health, Institute of Genetics, University of Copenhagen.; Issue Info: 1954, Vol. 7 Issue 1, p72; Thesaurus Term: Nitrogen; Thesaurus Term: Enzyme inhibitors; Subject Term: Cell differentiation; Subject Term: Melanins; Subject Term: Melanocytes; Subject Term: Amino acids; Subject Term: Neurospora crassa; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 26p; Document Type: Article L3 - 10.1111/1399-3054.ep15770136 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15770136&site=ehost-live&scope=site DP - EBSCOhost DB - eih ER - TY - JOUR ID - 1955-04352-001 AN - 1955-04352-001 AU - Bloch, Donald A. T1 - Some concepts in the treatment of delinquency. JF - Children JO - Children JA - Children Y1 - 1954/// VL - 1 SP - 49 EP - 56 CY - US PB - United States Children’s Bureau SN - 0009-4064 N1 - Accession Number: 1955-04352-001. Other Journal Title: Children Today. Partial author list: First Author & Affiliation: Bloch, Donald A.; National Institute of Mental Health, Washington, D. C. Release Date: 19550301. Correction Date: 20130617. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 8. Issue Publication Date: 1954. AB - The author maintains that delinquency seen as an interpersonal integration has implications for treatment. The concept of a defense in depth on a community level is a useful one. The treatment facilities are available; child guidance, court, and institutional levels are integrated with each other and staffed to some considerable degree by the same personnel. This gives opportunity for a comprehensive treatment program. Anxiety levels are reduced; the continuity of relationship is maintained. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - JUVENILE DELINQUENCY KW - TREATMENT OF KW - CRIME & DELINQUENCY KW - 1954 KW - No terms assigned KW - 1954 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-04352-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1954-08699-001 AN - 1954-08699-001 AU - Miller, Alan D. T1 - The institute of interpersonal relationships in public health: an evaluation. JF - Mental Hygiene. New York JO - Mental Hygiene. New York Y1 - 1954/// VL - 38 SP - 85 EP - 106 N1 - Accession Number: 1954-08699-001. PMID: 13132517 Partial author list: First Author & Affiliation: Miller, Alan D.; National Institute of Mental Health, College Park, Md. Release Date: 19541101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 22. Issue Publication Date: 1954. AB - A study of the responses on a specially designed questionnaire aimed at the evaluation of a public health institute on interpersonal relationships. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - CLINICAL PSYCHOLOGY KW - GUIDANCE KW - COUNSELING KW - 1954 KW - No terms assigned KW - 1954 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-08699-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1955-02917-001 AN - 1955-02917-001 AU - Cholden, Louis T1 - Some psychiatric problems in the rehabilitation of the blind. JF - Bulletin of the Menninger Clinic JO - Bulletin of the Menninger Clinic JA - Bull Menninger Clin Y1 - 1954/// VL - 18 SP - 107 EP - 112 CY - US PB - Guilford Publications SN - 0025-9284 N1 - Accession Number: 1955-02917-001. PMID: 13149996 Partial author list: First Author & Affiliation: Cholden, Louis; National Institute of Mental Health, Bethesda, Md. Release Date: 19550201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1954. AB - The adult who loses his sight usually reacts with a state of shock. As he begins to experience emotions again, his behavior and feelings resemble those in reactive depression. Before the patient can accept the reality of his blindness, he needs to experience this depression and efforts should not be made to prevent or abort it. It is a necessary precursor to relearning. He must believe that he is disabled but that he can learn to live with his disability. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - REHABILITATION KW - BLIND KW - PSYCHIATRIC PROBLEMS KW - PHYSICALLY HANDICAPPED KW - 1954 KW - No terms assigned KW - 1954 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-02917-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1955-05417-001 AN - 1955-05417-001 AU - Birren, James E. AU - Allen, William R. AU - Landau, H. G. T1 - The relation of problem length in simple addition to time required, probability of success and age. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1954/// VL - 9 SP - 150 EP - 161 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1955-05417-001. PMID: 13163370 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19550401. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 12. Issue Publication Date: 1954. AB - An analysis was made of the task of simple arithmetic addition. Time required (T) and probability of success (P) were studied as a function of the age of the subjects and the length of a single column of digits to be added. Data are reported on 413 subjects between the ages of 16 and 90 years. The elderly were slower for all lengths of problems, and showed less accuracy with increased length of problem. Empirical equations fitted to the data seem to be approximations to rational equations derived from an analysis of the nature of the task. A simulated physical system or model was described which incorporates assumed characteristics of the human subject doing addition. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - OLD AGE KW - & ADDITION PROFICIENCY KW - ARITHMETIC KW - ADDITION KW - & AGE KW - MATURITY & OLD AGE KW - 1954 KW - No terms assigned KW - 1954 DO - 10.1093/geronj/9.2.150 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-05417-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1955-07045-001 AN - 1955-07045-001 AU - Birren, James E. T1 - Age changes in mental abilities. JF - Journal of Business JO - Journal of Business Y1 - 1954/// VL - 27 SP - 156 EP - 163 N1 - Accession Number: 1955-07045-001. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, Md. Release Date: 19550501. Correction Date: 20161128. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 8. Issue Publication Date: 1954. AB - Psychological research on age changes in mental ability is reviewed in relation to the problem of choosing an optimum age for retirement. The topics discussed are speed, intelligence tests, verbal ability, learning and memory, creativity, education, mental disease and research needs. 'Mental abilities vary greatly in the extent to which they change with age… . Jobs requiring rapid integration of incoming serial information and demanding a response in a limited time are particularly unsuited for the abilities of older workers.' In view of the differences in characteristics of jobs and individuals '… decisions about continued employment, job shifting, or retirement might better be made over a span of years than at any fixed age.' 37 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - OLD AGE KW - MENTAL KW - ABILITIES KW - RETIREMENT KW - & MENTAL ABILITIES KW - ABILITY KW - AGE CHANGES KW - & RETIREMENT KW - MATURITY & OLD AGE KW - 1954 KW - No terms assigned KW - 1954 DO - 10.1086/294020 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-07045-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-001 AN - 2009-06034-001 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Scope of the problem and methods of study. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 1 EP - 5 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-001. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Disorders; Cardiovascular Reactivity; Cardiovascular System. Minor Descriptor: Essential Hypertension. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 5. AB - Our aim in the present study was to investigate as many aspects of cardiovascular function as we could and to observe the circumstances under which each one was altered. This chapter describes the scope and methods of the study. Ss were 216 patients with various cardiovascular disturbances were collected and followed; 135 presumably healthy Ss swerved as controls. Circulatory responses in areas of the human body other than those traditionally considered to be cardiovascular have been included in the present study. For detecting alterations in cardiovascular dynamics, only those methods which afforded a minimum of discomfort to the patient and the least possible disturbance of the experimental situation were used. Prominent among experimentally applied stimuli has been the 'stressful interview,' in which topics of known threatening significance in the subject's life were introduced for discussion while the indicators of cardiovascular function were being recorded. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - cardiovascular function KW - hypertension KW - stressful interview KW - cardiovascular reactivity KW - 1955 KW - Cardiovascular Disorders KW - Cardiovascular Reactivity KW - Cardiovascular System KW - Essential Hypertension KW - 1955 DO - 10.1037/14077-001 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-002 AN - 2009-06034-002 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Circulatory adjustments associated with muscular effort. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 6 EP - 16 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-002. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Disorders; Cardiovascular Reactivity; Exercise; Expectations; Heart Disorders. Minor Descriptor: Essential Hypertension; Fatigue; Muscles. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 11. AB - Exercise involving muscular work, requiring, as it does, an increase in peripheral circulation, calls forth a relatively uniform cardiovascular response. Ss were 35 subjects: 8 were healthy asymptomatic persons, 11 had complaints of palpitation and fatigability with or without exertional dyspnea but no demonstrable heart disease, and the remaining 16 had hypertensive, arteriosclerotic, rhematic or congenital heart disease. The extent and duration of the circulatory disturbance in these patients, however, did not correspond necessarily with the muscular work performed. In fact, the same response could be induced during rest merely by the anticipation of exercise and was often observed under circumstances of emotional stress without conscious anticipation of muscular effort. This was true whether the indicator of reduced exercise tolerance was the pulse rate, the height of the IJ wave of the ballistocardiogram, or the form of the electrocardiogram. It may be the symptoms of neurocirculatory asthenia are related to these disturbances in circulatory dynamics and to the fact that the 'exercise' pattern of hemodynamic adjustment was often invoked without exercise but during contemplation of troublesome life situations. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - heart disease KW - hypertension KW - cardiovascular disorders KW - cardiovascular activity KW - muscular work KW - exercise KW - cardiovascular response KW - fatigue KW - palpitations KW - anticipation KW - 1955 KW - Cardiovascular Disorders KW - Cardiovascular Reactivity KW - Exercise KW - Expectations KW - Heart Disorders KW - Essential Hypertension KW - Fatigue KW - Muscles KW - 1955 DO - 10.1037/14077-002 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-003 AN - 2009-06034-003 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Circulatory adjustments involving rhythm of the heart. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 17 EP - 30 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-003. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Cardiovascular Reactivity; Heart Disorders; Heart Rate; Stress; Stress Reactions. Minor Descriptor: Adaptation; Arrhythmias (Heart); Emotional States; Fibrillation (Heart); Tachycardia; Threat. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. AB - It has been observed that arrhythmias, including paroxysmal auricular tachycardia, extrasystoles, auricular fibrillation, and even the more serious paroxysmal ventricular tacycardia, occur in association with troublesome events in the day-to-day experiences of individuals who have no other detectable evidence of heart disease. It would appear that this variety of disorders of cardiac rhythm may be precipitated by or possibly fundamentally related to threats arising out of the life situation. It is certainly unnecessary to postulate underlying structural disease of the myocardium as a cause of arrhythmias even in the case of such potentially serious disorders as auricular fibrillation and ventricular tachycardia. It is noteworthy that paroxysmal ventricular tachycardia has also been reported by Harvey and Levine in association with emotional stress. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - circulatory adjustment KW - arrhythmias KW - extrasystoles KW - auricular fibrillation KW - paroxysmal ventricular tachycardia KW - stress KW - emotional stress KW - heart disease KW - threat KW - 1955 KW - Cardiovascular Reactivity KW - Heart Disorders KW - Heart Rate KW - Stress KW - Stress Reactions KW - Adaptation KW - Arrhythmias (Heart) KW - Emotional States KW - Fibrillation (Heart) KW - Tachycardia KW - Threat KW - 1955 DO - 10.1037/14077-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-004 AN - 2009-06034-004 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Circulatory adjustments involving peripheral vessels. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 31 EP - 44 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-004. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Blood Vessels; Cardiovascular Reactivity; Cardiovascular System; Physical Disorders; Stress. Minor Descriptor: Allergic Skin Disorders; Cardiovascular Disorders; Eczema; Migraine Headache. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. AB - The peripheral vasculature is capable of a rich variety of responses, local, regional and general, to many stimuli. Such changes in vascular function produce thermal, nutritive and other effects. Many important disturbances involving peripheral vessels are not customarily classified among cardiovascular disorders. These include vascular headache, Raynaud's syndrome, hives, eczema, and various disorders of mucous membranes. The vasomotor mechanisms which appear to be responsible for these phenomena have been shown to be set in motion by a variety of stimuli, including situations or events which have a threatening significance to the individual. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - Circulatory adjustment KW - periperal vessels KW - peripheral vasculature KW - cardiovascular reactivity KW - threat KW - life stress KW - physical disorders KW - vascular headache KW - Raynaud's syndrome KW - hives KW - eczema KW - mucous membrane disorders KW - 1955 KW - Blood Vessels KW - Cardiovascular Reactivity KW - Cardiovascular System KW - Physical Disorders KW - Stress KW - Allergic Skin Disorders KW - Cardiovascular Disorders KW - Eczema KW - Migraine Headache KW - 1955 DO - 10.1037/14077-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-005 AN - 2009-06034-005 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Essential hypertension—Natural history and symptomatology. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 45 EP - 55 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-005. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Essential Hypertension; Stress Reactions; Symptoms. Minor Descriptor: Adaptation; Stress; Threat. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. AB - Another disorder which appears initially to involve mainly peripheral vessels is essential hypertension. The diagnosis is one of exclusion and is made only in the absence of a discoverable reason for hypertension, such as congenital vascular anomaly, endocrine tumor or primary renal disorder. The label 'essential hypertension' is attached to a patient who is consistently observed to have an elevation of systolic and diastolic blood pressure at the times when he is examined by his physician. It is an old observation, and very easily confirmed, that patients with essential hypertension, and normal subjects as well, display an increase in arterial pressure when brought into certain situations involving threats to their personal security. The pertinence of these responses to the initial causation or ultimate perpetuation of sustained arterial hypertension, however, is not established. The investigator who studies hypertension is handicapped by the lack of relationship between height of the blood pressure and the presence or absence of symptoms and the lack of uniformity and predictability of the natural course. Some of the circumstances under which hypertension is observed have been reviewed, but it appeared more fruitful to focus attention on some of the underlying or associated hemodynamic adjustments which could be measured and recorded. Since the ballistocardiograph was used in many of these observations a description of the instrument and of its range of usefulness and reliability seems indicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - essential hypertension KW - stress reaction KW - threat KW - stress KW - symptoms KW - hemodynamic adjustment KW - natural history KW - 1955 KW - Disease Course KW - Essential Hypertension KW - Stress Reactions KW - Symptoms KW - Adaptation KW - Stress KW - Threat KW - 1955 DO - 10.1037/14077-005 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-006 AN - 2009-06034-006 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - The ballistocardiograph. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 56 EP - 67 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-006. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Blood Pressure; Cardiography; Cardiovascular Reactivity; Stress; Stress Reactions. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. AB - Ballistocardiography as a convenient if inexact indicator of cardiovascular dynamics is reviewed. It is pointed out that the method lends itself to prolonged and frequently repeated observation in a single subject and that the data thus obtained are satisfactorily reproducible. Alterations in the pattern under stress have been shown to correspond to or to combine the characteristics of the changes induced by subcutaneous injection with epinephrine on the one hand (increased cardiac output and reduced peripheral resistance), or with norepinephrine on the other (increased peripheral resistance and reduced cardiac output). In interpreting the data, however, no inferences are made concerning actual cardiac output or peripheral resistance, but rather the terms are used to indicate the characteristic and readily studied changes in the ballistocardiographic tracing. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - ballistocardiography KW - cardiovascular dynamics KW - stress KW - stress reactions KW - 1955 KW - Blood Pressure KW - Cardiography KW - Cardiovascular Reactivity KW - Stress KW - Stress Reactions KW - 1955 DO - 10.1037/14077-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-007 AN - 2009-06034-007 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Measurement of hemodynamics in essential hypertension. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 68 EP - 119 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-007. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter; Column/Opinion. Book Type: Classic Book. Language: English. Major Descriptor: Blood Pressure; Cardiovascular Reactivity; Cardiovascular System; Essential Hypertension; Stress Reactions. Minor Descriptor: Adaptation; Cardiovascular Disorders; Stress. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 52. AB - In our laboratory approximately 1400 tracings have been made on 150 subjects, including subjects with a variety of cardiovascular disturbances and normal subjects. The studies were done with the subject reclining on the ballistocardiographic table. Records were made during quiet breathing for several seconds out of every minute. Immediately before and after each record the arterial pressure was determined by means of a sphygmomanometer cuff wrapped around the left arm. The mean of these readings was used in the calculations. With reference to the relation of arterial pressure to the height of the IJ wave, three contrasting patterns of cardiovascular dynamics were evoked by various stimuli, including muscular effort, immersing the hand in cold water, or interviews concerning pertinent personal problems. It is shown, with appropriate documentation, that hemodynamic changes productive of elevated arterial pressure, reduced renal blood flow and increased blood viscosity occur as a part of an individual's adaptation to problems and challenges in his daily life. Special attention has been directed to two contrasting patterns of hemodynamic adjustment which occur alike in hypertensive and normotensive individuals under stress. One pattern appears to be identical with the 'exercise' pattern in which occurs an increase in blood pressure attributable to a rise in stroke volume without elevation of peripheral vascular resistance. The other pattern resembles that encountered in injury or hemorrhage in which occurs an increase in blood pressure attributable to an elevation in peripheral vascular resistance without a rise in stroke volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - hemodynamics KW - essential hypertension KW - cardiovascular disturbances KW - adaptation KW - daily life stressors KW - stress KW - 1955 KW - Blood Pressure KW - Cardiovascular Reactivity KW - Cardiovascular System KW - Essential Hypertension KW - Stress Reactions KW - Adaptation KW - Cardiovascular Disorders KW - Stress KW - 1955 DO - 10.1037/14077-007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-008 AN - 2009-06034-008 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - A survey of 114 patients with essential hypertension followed up to eight years. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 120 EP - 204 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-008. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Essential Hypertension; Personality Correlates; Stress Reactions; Symptoms. Minor Descriptor: Cardiovascular Reactivity; Stress; World View. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Followup Study. Page Count: 85. AB - Our survey and follow-up study of 114 patients with essential hypertension is in substantial agreement with other published series. It is the general consensus that it is a disease which begins in the first half-century of life, that there is a predominance of women and that the symptoms, although quite characteristic of the condition, have little to do with either the height of the blood pressure or the rate of arterial or arteriolar degeneration. More striking, it appears that neither the height nor duration of the elevation of arterial pressure provide a reliable indicator of severity or prognosis. Unaccountably some patients lose their evidences of hypertension, even after years of known high blood pressure. Possible explanations for this and considerations of treatment will be presented in the next chapter. A study of personality adjustment among the patients with hypertension did not delineate any characteristic personality 'type', but yielded strikingly similar data as regards values, attitudes and way of life. By and large the hypertensives had grown up feeling the need to excel but at the same time to avoid conflict or too vigorous self-assertion. These strivings, often opposed as they were, led frequently to dilemmas and were manifest by wary, tentative and non-committal attitudes with respect to important interpersonal relations and major endeavors in life. In the present series the 12 per cent of patients who lost all evidences of hypertension appeared to have developed a more confident and relaxed approach to life, a more optimistic outlook, and an improved capacity for self-assertion. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - essential hypertension KW - symptoms KW - disease course KW - personality KW - stress KW - stress reactions KW - world view KW - 1955 KW - Disease Course KW - Essential Hypertension KW - Personality Correlates KW - Stress Reactions KW - Symptoms KW - Cardiovascular Reactivity KW - Stress KW - World View KW - 1955 DO - 10.1037/14077-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-009 AN - 2009-06034-009 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Treatment of essential hypertension. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 205 EP - 224 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-009. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Essential Hypertension; Treatment Effectiveness Evaluation; Treatment. Minor Descriptor: Adjustment; Attitude Change; Drug Therapy; Emotional States; Exercise; Personality Correlates. Classification: Health Psychology & Medicine (3360). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 20. AB - This chapter considers treatments for hypertension and the difficulties in evaluating this therapy. Although the most widely accepted criterion of success is a sustained lowering of blood pressure, there is no proof that prognosis is actually altered thereby. In fact, there is some evidence, which suggests that differences in level of arterial pressure within the hypertensive range do not correlate with the progress of the disease or the ultimate outcomes. Antipressor drugs and surgical operations on various portions of the sympathoadrenal system have not gone far toward solving the problem of therapy in essential hypertension. Perhaps the most promising therapeutic approach is toward the patient as a whole and his general life adjustment. Even here, however, the results of therapy are only suggestive and it remains to be shown that the pathophysiologic process in essential hypertension can be significantly altered by any currently available measures. It is noteworthy that virtually all treatment programs, diverse as they are and usually enthusiastically reported by their proponents have, as a common denominator, a firm cooperative relationship between the patient and his physician. Vigorous muscular exercise is interdicted by most manuals on the therapy of essential hypertension. Moreover, the data presented in the present chapter indicate that relatively uninhibited expressions of aggression, vicarious or otherwise, may be associated with a lowering of arterial pressure. Therefore it might be reasonable to suggest prescription rather than proscription of vigorous muscular effort in essential hypertension in those patients whose hearts are well compensated and not enlarged. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - treatment KW - hypertension KW - treatment evaluation KW - drug therapy KW - exercise KW - emotional expression KW - life adjustment KW - 1955 KW - Essential Hypertension KW - Treatment Effectiveness Evaluation KW - Treatment KW - Adjustment KW - Attitude Change KW - Drug Therapy KW - Emotional States KW - Exercise KW - Personality Correlates KW - 1955 DO - 10.1037/14077-009 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-06034-010 AN - 2009-06034-010 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - General summary and formulation. T2 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// SP - 225 EP - 233 CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-010. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Essential Hypertension. Minor Descriptor: Disease Course; Etiology; Personality Correlates; Prognosis; Stress; Stress Reactions; Symptoms. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 9. AB - The major emphasis in the present study has been on the elusive syndrome called essential hypertension. It is recognized at the outset that data bearing on peripheral arterial pressure and pressor mechanisms do not necessarily bear on the processes of vascular degeneration which often accompany sustained elevation of arterial pressure. Elevated arterial pressure has been identified in association with several more or less well understood disturbances in the blood vessels, glands of internal secretion or kidneys, but by far the most frequent instances of sustained blood pressure elevation have been found to occur in the absence of these structural lesions. The common form of hypertension, called essential, has been found to be associated in varying degrees with degenerative changes in the arterioles here and there in the body, but mainly in the kidneys. There is seen, however, no predictable relationship between these changes and the height of the blood pressure or the duration of hypertension. Neither can the course of hypertension nor the likelihood of death from the disease be predicted in the early stages, although in general it has been reliably observed that the more labile the blood pressure, the better the prognosis. It has also been noted that the most overtly 'nervous' patients, who become red-faced during excitement and whose blood pressure falls to normal during sleep, seem to follow the most benign course. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - essential hypertension KW - etiology KW - disease course KW - prognosis KW - personality KW - stress reactions KW - symptoms KW - 1955 KW - Essential Hypertension KW - Disease Course KW - Etiology KW - Personality Correlates KW - Prognosis KW - Stress KW - Stress Reactions KW - Symptoms KW - 1955 DO - 10.1037/14077-010 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1955-05395-001 AN - 1955-05395-001 AU - Radke-Yarrow, Marian AU - Yarrow, Leon J. T1 - Child psychology. JF - Annual Review of Psychology JO - Annual Review of Psychology JA - Annu Rev Psychol Y1 - 1955/// VL - 6 SP - 1 EP - 28 CY - US PB - Annual Reviews SN - 0066-4308 N1 - Accession Number: 1955-05395-001. PMID: 14377357 Partial author list: First Author & Affiliation: Radke-Yarrow, Marian; National Institute of Mental Health, Bethesda, Md. Release Date: 19550401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 28. Issue Publication Date: 1955. AB - In this review of the literature on child psychology for year ending May, 1954 the authors point out that there is a slowly emerging dynamic point of view in research in this field. The review has the major sections: physical and motor development; learning, perception, and cognitive processes; intellectual development and functioning; personality; psychological problems and disorders; social psychology. 103-item bibliography. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - CHILD PSYCHOLOGY KW - REVIEW KW - BIBLIOGRAPHIES KW - PSYCHOLOGY KW - CHILD KW - CHILDHOOD & ADOLESCENCE KW - 1955 KW - No terms assigned KW - 1955 DO - 10.1146/annurev.ps.06.020155.000245 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-05395-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1956-04459-001 AN - 1956-04459-001 AU - Deasy, Leila Calhoun T1 - An index of social mobility. JF - Rural Sociology JO - Rural Sociology JA - Rural Sociol Y1 - 1955/// VL - 20 SP - 149 EP - 151 CY - US PB - Rural Sociological Society SN - 0036-0112 N1 - Accession Number: 1956-04459-001. Partial author list: First Author & Affiliation: Deasy, Leila Calhoun; National Institutes of Health, Bethesda, Md. Release Date: 19560301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Processes & Social Issues (2900). Page Count: 3. Issue Publication Date: 1955. AB - Movement from one prestige level or 'class' to another was measured by comparing the scores earned by male heads of households with those of their fathers on three factors: occupational (Hatt-North scale), educational (attended college or not), and religious. In the community studied the high prestige denominations were the Episcopal, Congregational and Presbyterian. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - SOCIAL KW - MOBILITY KW - INDEX OF KW - SOCIAL INSTITUTIONS KW - 1955 KW - No terms assigned KW - 1955 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-04459-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1956-05955-001 AN - 1956-05955-001 AU - Lamson, Warren C. T1 - Integrating mental health services into the community health and welfare program. JF - Journal of Psychiatric Social Work JO - Journal of Psychiatric Social Work Y1 - 1955/// VL - 24 SP - 244 EP - 249 N1 - Accession Number: 1956-05955-001. Partial author list: First Author & Affiliation: Lamson, Warren C.; National Institute of Mental Health, Bethesda, Md. Release Date: 19560401. Correction Date: 20151207. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Health. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 6. Issue Publication Date: 1955. AB - Basic principles underlying the integration of mental health services into community health and welfare programs are presented, together with some typical obstacles which can prevent effective integration. In illustration the author describes specific experimental programs in a variety of communities. The authors emphasizes that professional 'experts' should not assume exclusive responsibility or planning for mental health programs. Ultimately the citizens of community must assume this responsibility, with the help of specialists. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PUBLIC KW - & MENTAL HEALTH KW - MENTAL HEALTH KW - IN PUBLIC HEALTH KW - CLINICAL PSYCHOLOGY KW - GUIDANCE KW - COUNSELING KW - 1955 KW - Community Health KW - 1955 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-05955-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - BOOK ID - 2009-06034-000 AN - 2009-06034-000 AU - Wolf, Stewart AU - Cardon, Phillippe V. Jr. AU - Shepard, Edward M. AU - Wolff, Harold G. T1 - Life stress and essential hypertension: A study of circulatory adjustments in man. Y1 - 1955/// CY - Baltimore, MD, US PB - Williams & Wilkins Co N1 - Accession Number: 2009-06034-000. Partial author list: First Author & Affiliation: Wolf, Stewart; Department of Medicine, University of Oklahoma School of Medicine, OK, US. Release Date: 20110815. Correction Date: 20121008. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Adaptation; Cardiovascular Reactivity; Cardiovascular System; Essential Hypertension; Stress Reactions. Minor Descriptor: Life Experiences; Stress. Classification: Cardiovascular Disorders (3295). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 253. AB - Essential hypertension has proved to be one of the most elusive medical problems of our day. Although the underlying hemodynamic changes are fairly well understood, the mechanisms whereby the changes are brought about and the factors responsible for activating them are still obscure. In view of the oft-heard implications that 'wear and tear' and 'stresses of modern civilization' have something to do with the process, the authors have set out to review the data linking circulatory adjustments to life experiences. In this volume we have tried to pull together into a coherent statement the results of studies on cardiovascular function carried out over the past ten years in the laboratories of Cornell New York Hospital, including a few supplementary observations made in the Department of Medicine at the University of Oklahoma and the Oklahoma Medical Research Foundation. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - essential hypertension KW - life stress KW - circulatory adjustment KW - life experiences KW - cardiovascular function KW - 1955 KW - Adaptation KW - Cardiovascular Reactivity KW - Cardiovascular System KW - Essential Hypertension KW - Stress Reactions KW - Life Experiences KW - Stress KW - 1955 U1 - Sponsor: Public Health Service, National Institutes of Health, National Heart Institute, US. Recipients: No recipient indicated U1 - Sponsor: Commonwealth Fund. Recipients: No recipient indicated DO - 10.1037/14077-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06034-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Gentile, Arthur C. AU - Klein, Richard M. T1 - The Apparent Necessity of Indoleacetic Acid for the Growth of Diplodia (Fungi Imperfecti). JO - Physiologia Plantarum JF - Physiologia Plantarum Y1 - 1955/04// VL - 8 IS - 2 M3 - Article SP - 291 EP - 299 PB - Wiley-Blackwell SN - 00319317 AB - Focuses on the results of growth studies on a strain of Diplodia in the presence of 2,4,6 trichlorophenoxyacetic acid (TCPA) or indoleacetic acid (IAA) and combination of these two compounds. Necessity of IAA for the growth of Diploida; Effect of IAA and TCPA on the growth of Diploidia; Implications of the findings of these studies. KW - Diplodia KW - Plant hormones KW - Acetic acid KW - Sphaeropsidaceae KW - Plant physiology KW - Indoleacetic acid KW - Plant growth promoting substances N1 - Accession Number: 15996297; Gentile, Arthur C. 1,2,3; Klein, Richard M. 1,2; Affiliations: 1: Department of Botany, Duke University, Durham, North Carolina; 2: The New Botanical Garden, New York, N. Y.; 3: Public Health Service Research Fellow, National Cancer Institute; Issue Info: 1955, Vol. 8 Issue 2, p291; Thesaurus Term: Diplodia; Thesaurus Term: Plant hormones; Thesaurus Term: Acetic acid; Thesaurus Term: Sphaeropsidaceae; Thesaurus Term: Plant physiology; Subject Term: Indoleacetic acid; Subject Term: Plant growth promoting substances; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15996297&site=ehost-live&scope=site DP - EBSCOhost DB - eih ER - TY - JOUR AU - Kohn, Melvin L. AU - Clausen, John A. T1 - SOCIAL ISOLATION AND SCHIZOPHRENIA. JO - American Sociological Review JF - American Sociological Review Y1 - 1955/06// VL - 20 IS - 3 M3 - Article SP - 265 EP - 273 SN - 00031224 AB - Of the several hypotheses relating the frequency of mental disorder to social conditions, none has been more persistently enunciated than that which proposes that schizophrenia is the outgrowth of social isolation. First stated by Faris in 1934, this hypothesis subsequently seemed consistent with and indeed explanatory of the findings of Faris and Dunham's classic ecological study of mental disorder. Faris and Dunham ascertained that high rates of first hospital admissions for schizophrenia are found in areas of the city characterized by high residential mobility and low socio-economic status, among ethnic group persons living in non-ethnic areas, and among the foreign born populations of the slums. All of these indices were regarded as reflecting tendencies toward the social isolation of certain segments of the population. Faris suggested that any form of isolation that cuts the person off from intimate social relations for an extended period of time may possibly lead to this form of mental disorder. More recent statements have suggested that isolation is a result of incongruent intra-familial and extra-familial orientations toward the child and represents a stage in a typical process for schizophrenics. KW - SCHIZOPHRENIA KW - ETHNIC groups KW - MENTAL illness KW - SOCIAL participation KW - SOCIAL isolation KW - SOCIAL status N1 - Accession Number: 12786754; Kohn, Melvin L. 1; Clausen, John A. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun55, Vol. 20 Issue 3, p265; Subject Term: SCHIZOPHRENIA; Subject Term: ETHNIC groups; Subject Term: MENTAL illness; Subject Term: SOCIAL participation; Subject Term: SOCIAL isolation; Subject Term: SOCIAL status; Number of Pages: 9p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786754&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Gentile, Arthur C. AU - Naylor, Aubrey W. T1 - The Metabolism of Rumex Virus Tumors. Terminal Respiratory enzymes. JO - Physiologia Plantarum JF - Physiologia Plantarum Y1 - 1955/07// VL - 8 IS - 3 M3 - Article SP - 682 EP - 690 PB - Wiley-Blackwell SN - 00319317 AB - A survey was made of the terminal respiratory enzymes in Rumex virus tumor tissue grown in culture. The oxygen uptake of slices of Rumex virus tumors was inhibited about 45 per cent by 0.001 M cyanide. This inhibition suggested the presence of a heavy-metal mediated oxidase system. Cytochrome oxidase. DPNH-linked cytochrome c reductase, and succinic dehydrogenase were found to be present. Catalase and peroxidase activities were also demonstrated. The copper-protein oxidases - polyphenol oxidase, laccase, and ascorbic acid oxidase, were absent in this tissue. Although a residual cyanide respiration suggested the presence of a flavin oxidase, attempts to show glycolic acid dehydrogcnase activity were unsuccessful. [ABSTRACT FROM AUTHOR] AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - Plant metabolism KW - Plant physiology KW - Metabolism KW - Cytochromes KW - Metalloenzymes KW - Dehydrogenases N1 - Accession Number: 15794144; Gentile, Arthur C. 1; Naylor, Aubrey W. 2; Affiliations: 1: Public Health Service Research Fellow of the National Cancer Institute.; 2: Department of Botany, Duke University, Durham, North Carolina.; Issue Info: 1955, Vol. 8 Issue 3, p682; Thesaurus Term: Plant metabolism; Thesaurus Term: Plant physiology; Subject Term: Metabolism; Subject Term: Cytochromes; Subject Term: Metalloenzymes; Subject Term: Dehydrogenases; Number of Pages: 9p; Document Type: Article L3 - 10.1111/1399-3054.ep15794144 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15794144&site=ehost-live&scope=site DP - EBSCOhost DB - eih ER - TY - JOUR ID - 2005-10142-018 AN - 2005-10142-018 AU - Bayley, Nancy T1 - Review of Atlas of men. JF - Psychological Bulletin JO - Psychological Bulletin JA - Psychol Bull Y1 - 1955/07// VL - 52 IS - 4 SP - 367 EP - 368 CY - US PB - American Psychological Association SN - 0033-2909 SN - 1939-1455 N1 - Accession Number: 2005-10142-018. Partial author list: First Author & Affiliation: Bayley, Nancy; National Institute of Mental Health, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Human Males; Photographs; Somatotypes. Classification: Personality Psychology (3100). Population: Human (10). Reviewed Item: Sheldon, William H.; Dupertuis, C. Wesley; McDermott, Eugene. Atlas of men=New York: Harper, 1954. Pp. xvi + 357. $10.00; 1954. Page Count: 2. Issue Publication Date: Jul, 1955. Copyright Statement: American Psychological Association. 1955. AB - Reviews the book, Atlas of men by William A. Sheldon (see record [rid]1955-01908-000[/rid]). This book contains somatotype photographs of 1,175 men, selected as representative of the 88 somatotypes identified in the total sample of some 46,000 men ranging in age from 18 to 65 years. As the book is primarily a supplement to the earlier volumes, it is necessary to turn to them for detailed descriptions of the criteria for ratings, unless one can learn, by repeated leafing through the photographs, to identify the differentiating factors between, say, a 2 and a 3 in ectomorphy. For those who are concerned with the problem of physique and its relations to personality and to disease, this book is provocative and a challenge to further research on the hypotheses and assumptions presented. For those who use the Atlas as a tool or guide for evaluating subjects, diligent study of the many illustrations should contribute to proficiency in somatotyping. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - somatotype photographs KW - Atlas KW - men KW - 1955 KW - Human Males KW - Photographs KW - Somatotypes KW - 1955 U2 - Sheldon, William H.; Dupertuis, C. Wesley; McDermott, Eugene. (1954); Atlas of men; New York: Harper, 1954. Pp. xvi + 357. $10.00 DO - 10.1037/h0039007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10142-018&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-001 AN - 2009-02921-001 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Introduction. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 13 EP - 15 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-001. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Pathology. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - In the present handbook, our scope is less broad. We shall attempt to give a brief, and so far as possible, factual presentation of the major clinical psychiatric problems that the general practitioner and medical student will commonly encounter in hospitals, clinics, and private practice. As much as possible, this book will be organized as are other medical synopses to serve as a convenient easy reference. The major topic headings of the Diagnostic and Statistical Manual of Mental Disorders will be used. Where knowledge exists, the histological, physiological, or chemical pathology of the brain will be described. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - clinical psychiatric problems KW - pathology KW - 1956 KW - Mental Disorders KW - Pathology KW - 1956 DO - 10.1037/13188-001 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-002 AN - 2009-02921-002 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - History of psychiatric thought. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 16 EP - 21 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-002. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: History; Mental Disorders; Psychiatry. Classification: History & Systems (2140). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 6. AB - Man has always feared mental illness and the tendency to ascribe its phenomena to supernatural causes is even yet extant. This chapter examines the history of psychiatric thought. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental illness KW - history KW - psychiatric thought KW - 1956 KW - History KW - Mental Disorders KW - Psychiatry KW - 1956 DO - 10.1037/13188-002 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-003 AN - 2009-02921-003 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Examination of the patient. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 22 EP - 23 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-003. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Patient History. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 2. AB - This chapter discusses the purpose of the examination of the patient and its uses. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - patient examination KW - 1956 KW - Patient History KW - 1956 DO - 10.1037/13188-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-004 AN - 2009-02921-004 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The initial psychiatric interview. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 24 EP - 27 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-004. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychodiagnostic Interview. Minor Descriptor: Mental Disorders; Patients; Psychiatric Evaluation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Interview. Page Count: 4. AB - In psychiatry, therapy and history-taking go hand in hand. Diagnosis and plans for treatment depend upon the results of appraisal of the psychological functioning of the patient. Initial immediate planning, working diagnoses, hospital orders, and instructions to aides and nurses must often be formulated after brief contact with the patient. This initial examination is also known as the 'mental' or 'behavioral status.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - initial examination KW - psychological functioning KW - behavioral status KW - mental status KW - psychiatric interview KW - 1956 KW - Psychodiagnostic Interview KW - Mental Disorders KW - Patients KW - Psychiatric Evaluation KW - 1956 DO - 10.1037/13188-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-005 AN - 2009-02921-005 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The complete case study. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 28 EP - 31 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-005. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Case Report; History; Psychodiagnostic Interview. Minor Descriptor: Psychiatric Evaluation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. AB - The psychiatric case study is completed not from one but from several interviews. In fact, psychotherapeutic interviews extending over many months time are, at least in part, an elaboration and addition to the patient's history. Over the course of such interviews one seeks to characterize the patient in terms of finding repetitive patterns of behavior which frequently associate with significant life events. The stress precipitating a symptom may be in the present or lie in the past. We are not concerned with how 'statistically' abnormal a trait is in the population at large but rather how much does it bother or affect this individual patient. The history obtained from the patient may be unreliable or lacking in detail. Relatives (who should be identified in the chart) may contribute additional history. Friends, employees, school records, etc., can all serve to round out the picture. The following outline presents a form to follow in writing the complete history. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric case study KW - complete history KW - psychotherapeutic interviews KW - 1956 KW - Case Report KW - History KW - Psychodiagnostic Interview KW - Psychiatric Evaluation KW - 1956 DO - 10.1037/13188-005 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-006 AN - 2009-02921-006 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - General physical and neurological examination. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 32 EP - 35 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-006. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Neurology; Physical Examination; Psychiatric Patients. Minor Descriptor: Neuropsychological Assessment. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. AB - This chapter examines the importance of both the general physical examination and the neurological examination of the psychiatric patient. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - neurological examination KW - physical examination KW - psychiatric patient KW - 1956 KW - Neurology KW - Physical Examination KW - Psychiatric Patients KW - Neuropsychological Assessment KW - 1956 DO - 10.1037/13188-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-007 AN - 2009-02921-007 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The problem of examining the patient for aphasia, agnosia, and apraxia. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 36 EP - 40 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-007. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Agnosia; Aphasia; Apraxia; Psychiatric Evaluation. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - This chapter discusses the problems of examining patients for aphasia, agnosia, and apraxia. Each of these disorders are described and ways for examining are provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - patient examination KW - aphasia KW - agnosia KW - apraxia KW - 1956 KW - Agnosia KW - Aphasia KW - Apraxia KW - Psychiatric Evaluation KW - 1956 DO - 10.1037/13188-007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-008 AN - 2009-02921-008 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Electroencephalographic examination. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 41 EP - 45 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-008. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Electroencephalography; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - This chapter looks at the use of electroencephalogram in the examination of psychiatric patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric patients KW - electroencephalogram KW - 1956 KW - Electroencephalography KW - Psychiatric Patients KW - 1956 DO - 10.1037/13188-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-009 AN - 2009-02921-009 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Psychological examination. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 46 EP - 61 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-009. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatric Patients; Psychological Assessment; Psychological Report. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. AB - In the psychiatric team the psychologist may function as a therapist, expert on research design or as a psychological theoretician. His unique contribution to clinical psychiatry, however, lies in the realm of diagnostic testing. In those situations where prolonged observation of the patient is not feasible, or where it is desirable quickly to pick up clues to covert symptomatology, the psychological test battery can be of great value. The psychologist gathers his data from observations of the patient functioning within the framework of a standardized test situation. His battery of psychological tests is carefully planned with a series of specific questions in mind and aimed to assess the patient's assets, conflicts, major defenses against anxiety and amenability to various forms of treatment. The report of psychological findings usually includes a descriptive summary of the patient's personality problems. In order to obtain the greatest value from the psychologist's report, however, the psychiatrist should have some familiarity with the test instruments used. The following section discusses briefly those tests that are commonly included in the diagnostic psychological battery. Some mention is made of their component parts and scoring scales, but for further details the reader is referred to the list of suggested readings. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychological examination KW - psychiatric patients KW - diagnostic psychological battery KW - 1956 KW - Psychiatric Patients KW - Psychological Assessment KW - Psychological Report KW - 1956 DO - 10.1037/13188-009 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-010 AN - 2009-02921-010 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Psychodynamic concepts of personality development. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 62 EP - 67 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-010. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Early Experience; Emotional Development; Personality Development; Psychiatric Patients; Psychodynamics. Minor Descriptor: Etiology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 6. AB - In this section will be mentioned briefly a few common concepts which psychiatrists find useful in relating patients' childhood experiences to their adult emotional illnesses. For often it seems clear not only that constitutional factors and immediate life stresses have operated as possible causes but also that the groundwork for later illness was laid in chronically maladaptive attitudes and behaviors unwittingly fostered by the human environment of childhood. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychodynamic concepts KW - personality development KW - emotional development KW - childhood experiences KW - psychiatric patients KW - 1956 KW - Early Experience KW - Emotional Development KW - Personality Development KW - Psychiatric Patients KW - Psychodynamics KW - Etiology KW - 1956 DO - 10.1037/13188-010 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-011 AN - 2009-02921-011 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The problem of classification. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 68 EP - 70 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-011. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Psychological Terminology. Minor Descriptor: Psychodiagnostic Typologies. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - The classification of mental disorders is based upon the description of behavioral symptoms and varies over the years with changes in psychologic theory. In the following pages we have sought, where practical, to indicate not only the latest official psychiatric nomenclature but also some of the names popularly used as roughly equivalent terms. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - classification KW - mental disorders KW - psychiatric nomenclature KW - 1956 KW - Mental Disorders KW - Psychological Terminology KW - Psychodiagnostic Typologies KW - 1956 DO - 10.1037/13188-011 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-011&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-012 AN - 2009-02921-012 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Standard nomenclature, diseases of the psychobiologic unit as prepared by the Committee on Nomenclature and Statistics of the American Psychiatric Association. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 71 EP - 75 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-012. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Disorders; Psychobiology; Terminology. Minor Descriptor: Psychiatry. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - This chapter presents standard nomenclature for diseases of the psychobiologic unit as prepared by the Committee on Nomenclature and Statistics of the American Psychiatric Association. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - American Psychiatric Association KW - standard nomenclature KW - psychobiologic diseases KW - 1956 KW - Disorders KW - Psychobiology KW - Terminology KW - Psychiatry KW - 1956 DO - 10.1037/13188-012 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-013 AN - 2009-02921-013 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Disorders caused by or associated with impairment of brain tissue function. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 76 EP - 108 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-013. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Brain Damage. Minor Descriptor: Chronicity (Disorders). Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 33. AB - In this section we will discuss both acute and chronic brain disorders. We would here stress the similarities among the 'toxic' and 'organic' psychoses and point out that although some rather characteristic differences can occur with a specific agent or anatomic predilection of lesion, yet perhaps more striking are the similarities which produce a basic syndrome consisting of: 1. Impairment of orientation. 2. Impairment of intellectual functions including comprehension, calculation, knowledge, learning, judgment, and recent memory. Remote memory is at times preserved. 3. Lability and shallowness of affect. Differences in the clinical picture may occur. Presumably differences in personality structure account for the appearance of such 'types' as paranoid, depressed, manic, etc., listed under individually described psychoses due to widely different agents. The section on delirium discusses the typical reversible, toxic psychoses which may, when the brain damage is severe, likewise progress to an irreversible 'organic syndrome.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - chronic brain disorders KW - brain damage KW - acute brain disorders KW - brain tissue function impairment KW - 1956 KW - Brain Damage KW - Chronicity (Disorders) KW - 1956 DO - 10.1037/13188-013 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-014 AN - 2009-02921-014 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Disorders of psychogenic origin (or without clearly defined physical cause or structural change in the brain). T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 109 EP - 165 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-014. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Neuroticism; Personality Disorders; Psychosis; Somatoform Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 57. AB - This chapter looks at disorders of psychogenic origin. Four types are discussed including a. psychotic disorders, b. psychoneurotic disorders, c. psychophysiologic autonomic and visceral disorders, and d. personality disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychophysiologic autonomic & visceral disorders KW - personality disorders KW - psychogenic origin KW - psychotic disorders KW - psychoneurotic disorders KW - 1956 KW - Neuroticism KW - Personality Disorders KW - Psychosis KW - Somatoform Disorders KW - 1956 DO - 10.1037/13188-014 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-014&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-015 AN - 2009-02921-015 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Mental deficiency. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 166 EP - 168 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-015. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Intellectual Development Disorder. Minor Descriptor: Treatment. Classification: Mental Retardation (3256); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - This chapter defines and describes various aspects of mental deficiency. Steps in treating mental deficiency are listed. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental deficiency KW - treatment KW - Mental Retardation KW - 1956 KW - Intellectual Development Disorder KW - Treatment KW - 1956 DO - 10.1037/13188-015 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-016 AN - 2009-02921-016 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Child psychiatry. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 169 EP - 173 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-016. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Child Psychiatry; Mental Disorders. Minor Descriptor: Diagnosis; Etiology; Treatment. Classification: Psychological Disorders (3210). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - Interest in child psychiatry has developed rapidly over the past quarter of a century. The general principles underlying etiology, diagnosis, and therapy of adult psychiatric disorders apply also in child psychiatry. The new specialty of child psychiatry is really a multidisciplined one. While the rationale for treatment grows out of the child's problem, most frequently the child is treated in conjunction with the family or larger social grouping. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - child psychiatry KW - psychiatric disorders KW - treatment KW - etiology KW - diagnosis KW - 1956 KW - Child Psychiatry KW - Mental Disorders KW - Diagnosis KW - Etiology KW - Treatment KW - 1956 DO - 10.1037/13188-016 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-016&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-017 AN - 2009-02921-017 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The psychiatric treatment team. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 174 EP - 177 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-017. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Interdisciplinary Treatment Approach; Psychiatry. Minor Descriptor: Nurses; Physicians; Psychiatrists; Psychologists; Social Workers. Classification: Health & Mental Health Services (3370); Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. AB - As the multidimensional nature of many illnesses has become clearer, the focus of medical concern has begun to move from treating 'the' illness to treating interacting dysfunctions of related systems either within the patient (biological or physiological) or which impinge upon the patient from without (environmental or social). To employ this complex concept of disease often requires a harmoniously effective team of specialists. This is particularly true in psychiatry where disabling disorders may, in a sense, reside as much within the disturbed relationships surrounding the patient as within the patient himself. Here, therefore, the therapeutic task may involve working in a coordinated manner with several 'patients' as with the patient and his family or with the patient and his employer. Depending upon the setting for treatment, whether state hospital, general hospital, clinic, school or juvenile court, the professional identity of members of the treatment team varies considerably. Thus in a hospital under the supervision of the occupational therapist, a person trained primarily as a musician, artist, or teacher may perform a variety of socializing and ego supportive functions. Within the juvenile court, the probation officer or lawyer may be called upon to perform functions the aims of which do not differ, substantially, from the goals of supportive psychiatric treatment. In medical settings, the primary members of the team may commonly include the psychiatrist, internist (surgeon or pediatrician), social worker, psychologist, and nurse. For special problems the resources available from a mental health oriented minister, dietitian, vocational guidance specialist, marriage counselor, physical therapist, library assistant or a volunteer aide, should be kept in mind. This chapter focuses on the psychiatrist, the collaborating physician, the social worker, the psychologist, and the nurse. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - social worker KW - collaborating physician KW - psychiatrist KW - psychologists KW - nurse KW - psychiatric treatment team KW - 1956 KW - Interdisciplinary Treatment Approach KW - Psychiatry KW - Nurses KW - Physicians KW - Psychiatrists KW - Psychologists KW - Social Workers KW - 1956 DO - 10.1037/13188-017 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-017&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-018 AN - 2009-02921-018 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Individual psychotherapy. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 178 EP - 186 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-018. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Individual Psychotherapy. Minor Descriptor: Psychotherapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 9. AB - Of the many qualities of different psychotherapeutic relationships, we will present only those common aspects which seem to lend themselves to brief verbal description. Topics discussed in this chapter the task, the place, the time, the doctor, the therapeutic process, the content, the doctor-patient relationship, supervision and consultation, types of therapy, and termination of psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - therapeutic process KW - individual psychotherapy KW - 1956 KW - Individual Psychotherapy KW - Psychotherapeutic Processes KW - 1956 DO - 10.1037/13188-018 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-018&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-019 AN - 2009-02921-019 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Group therapy. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 187 EP - 190 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-019. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Group Psychotherapy. Classification: Group & Family Therapy (3313). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 4. AB - Since ancient times many leaders of men, particularly state or religious leaders, have recognized the power of a unified group in producing certain psychological changes within individual members of the group. Wherever individuals form such a stable group for the purpose of relieving symptoms or strengthening certain personality functions, group therapy may be said to exist. Although some of the qualities of a group and part of the direction in which it proceeds depend upon the personality of the group leader, it is important to recognize that any group has the latent power of self-direction; it may, in one way or another, resist a leader who tries to produce changes which are too divergent from the standards, beliefs or defenses of the members. The effects a group has upon participants' personality or social adjustment seem to be influenced by the tolerance developed within the group for emotional expression, for self scrutiny without loss of self esteem, for attempting corrective emotional experiences, and for identifying or empathizing with each other. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - group therapy KW - 1956 KW - Group Psychotherapy KW - 1956 DO - 10.1037/13188-019 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-019&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-020 AN - 2009-02921-020 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The convulsive therapies. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 191 EP - 198 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-020. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Electroconvulsive Shock Therapy; Mental Disorders. Minor Descriptor: Seizures. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. AB - The production of convulsive seizures by pharmacologic means was introduced by von Meduna as a treatment for schizophrenia. Later Cerletti and Bini (1937) introduced the simpler method of electroconvulsive therapy (EST, ECT). The manner in which treatments of this type produce remission from emotional disorder is not understood, but their ability to relieve the symptoms of psychotic depression is universally accepted. Their effectiveness in other psychiatric disorders, however, is still open to question. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric disorders KW - convulsive seizures KW - electroconvulsive therapy KW - convulsive therapies KW - 1956 KW - Electroconvulsive Shock Therapy KW - Mental Disorders KW - Seizures KW - 1956 DO - 10.1037/13188-020 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-020&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-021 AN - 2009-02921-021 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Insulin therapy. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 199 EP - 203 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-021. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Insulin Shock Therapy; Psychosis. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - The use of insulin to induce severe hypoglycemic states for the treatment of psychoses was introduced by Manfred Sakel in Vienna in 1933. The term 'insulin shock' refers to the state of vasomotor collapse induced by this method. This chapter looks at the indications, preparatory, contraindications, technique, complications, and results of insulin therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - insulin therapy KW - psychoses KW - 1956 KW - Insulin Shock Therapy KW - Psychosis KW - 1956 DO - 10.1037/13188-021 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-021&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-022 AN - 2009-02921-022 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Psychosurgery. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 204 EP - 208 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-022. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Psychosurgery. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - Techniques of operating upon the human brain for the relief of psychiatric disorder originated from pioneer work of the Swiss psychiatrist Burkhardt (1888), Moniz and Lima of Portugal (1936) and subsequent popularization of the procedure in the United States by Freeman and Watts. Even after almost twenty years and as many thousand operations, however, the subject of lobotomy remains a controversial issue among psychiatrists. In part this stems from the tendency to reserve this brain mutilating procedure for patients who have failed with all other measures of treatment. Naturally the number of 'cures' in such material will not be great. As with other modes of therapy, the best results are obtained if grossly deteriorated patients are avoided and operation is reserved for patients who preserve some evidence of vigorous emotional life. Yet even among chronic backward populations, this procedure combined with an active postoperative program has in some hospitals produced impressive results. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric disorder KW - psychosurgery KW - 1956 KW - Mental Disorders KW - Psychosurgery KW - 1956 DO - 10.1037/13188-022 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-022&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-023 AN - 2009-02921-023 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Drug therapies. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 209 EP - 216 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-023. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Drug Therapy; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. AB - This chapter looks at the use of drug therapies in treating mental disorders. A reference list of drugs and doses having principal effect on CNS is provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental disorders KW - drug therapies KW - 1956 KW - Drug Therapy KW - Mental Disorders KW - 1956 DO - 10.1037/13188-023 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-023&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-024 AN - 2009-02921-024 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Hydrotherapy. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 217 EP - 219 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-024. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Treatment. Classification: Specialized Interventions (3350). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - The remedial use of water for mental ills has its origin in the baths of ancient times and is today all too frequently neglected in the hospital management of psychiatric patients. Application may be direct as in tubs, showers, sprays, and douches or by means of compresses or packs. The temperature may be varied as stimulative or sedative effects are desired. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental ills KW - hydrotherapy KW - 1956 KW - Mental Disorders KW - Treatment KW - 1956 DO - 10.1037/13188-024 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-024&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-025 AN - 2009-02921-025 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Management of suicidal patients. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 220 EP - 222 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-025. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatric Patients; Suicide; Suicide Prevention; Treatment. Minor Descriptor: Mortality Rate. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - Suicide is the leading cause of death among psychiatric patients. After detailing various suicide statistics, the chapter describes the management of suicidal patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - suicide statistics KW - suicidal patients KW - suicide management KW - 1956 KW - Psychiatric Patients KW - Suicide KW - Suicide Prevention KW - Treatment KW - Mortality Rate KW - 1956 DO - 10.1037/13188-025 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-025&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-026 AN - 2009-02921-026 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Management of civilian disaster. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 223 EP - 225 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-026. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Disasters; Emergency Management. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - Sudden catastrophes endangering or disrupting the physical world about us take their toll both in injury or death and in emotional disorder. Exposure to unexpected personal danger, to witnessing threatened or actual gruesome damage of loved ones, and experiencing separation from family and friends can tax the strongest personalities. Whether or not disaster produces an acute emotional disorder seems to depend upon a variety of factors. The absence of any prior warning permits no preparatory action and may rob the victim of necessary information to interpret realistically what he experiences. Degree and duration of physical stress, geographical closeness to the area of greatest danger, and previous susceptibility to anxiety apparently influence the likelihood of breakdown. Prophylactic social planning can do much to provide emergency channels of information and to help individuals find their most useful role at the time of disaster. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - catastrophes KW - civilian disaster KW - social planning KW - 1956 KW - Disasters KW - Emergency Management KW - 1956 DO - 10.1037/13188-026 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-026&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-027 AN - 2009-02921-027 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Management of psychiatric problems in the military setting. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 226 EP - 228 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-027. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Disorders; Military Personnel. Classification: Psychological Disorders (3210); Military Psychology (3800). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - The role of the psychiatrist in the military setting is structured, defined, and limited by the needs and mission of the Armed Forces. Even more than in civilian practice, the needs of the social group are pre-eminent, whereas the expectations of the individual patient and the physician are secondary. The therapeutic aim, however, is the same; namely, to help the patient to function effectively and comfortably within the current situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - military setting KW - psychiatric problems KW - 1956 KW - Mental Disorders KW - Military Personnel KW - 1956 DO - 10.1037/13188-027 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-027&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-028 AN - 2009-02921-028 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - Forensic psychiatry. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 229 EP - 233 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-028. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Forensic Psychiatry. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - This chapter examines aspects of forensic psychiatry. Topics discussed include commitment procedures, sexual offenses, mental incompetency, and marriage and divorce. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - forensic psychiatry KW - 1956 KW - Forensic Psychiatry KW - 1956 DO - 10.1037/13188-028 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-028&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2009-02921-029 AN - 2009-02921-029 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - The psychiatrist and mental health. T2 - A synopsis of contemporary psychiatry. Y1 - 1956/// SP - 234 EP - 236 CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-029. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Mental Health; Psychiatrists. Classification: Psychological & Physical Disorders (3200); Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - This chapter examines mental health and the role the psychiatrist. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health KW - psychiatrists KW - 1956 KW - Mental Health KW - Psychiatrists KW - 1956 DO - 10.1037/13188-029 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-029&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-21660-008 AN - 2006-21660-008 AU - Felix, Robert H. T1 - The Role of the Federal Government in Mental Health. T2 - Centennial papers: Saint Elizabeths Hospital 1855-1955. Y1 - 1956/// SP - 117 EP - 126 CY - Washington, DC, US PB - Centennial Commission Saint Elizabeths Hospital N1 - Accession Number: 2006-21660-008. Partial author list: First Author & Affiliation: Felix, Robert H.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061218. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Government; Government Agencies; Mental Health; Mental Health Programs; Mental Health Services. Minor Descriptor: Government Programs. Classification: Health & Mental Health Treatment & Prevention (3300). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 10. AB - Participation of the federal government in mental health programs covers a broad range of activities, including services to the mentally ill, financial assistance to the states in building mental institutions, and maintenance and support of preventive and control programs. The principal responsibility for the national mental health program is focuses on the National Institute of Mental Health (NIMH). This chapter focuses on the activities and services of NIMH. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - federal government KW - US KW - mental health KW - mental health services KW - National Institute of Mental Health KW - 1956 KW - Government KW - Government Agencies KW - Mental Health KW - Mental Health Programs KW - Mental Health Services KW - Government Programs KW - 1956 DO - 10.1037/11320-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21660-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2005-06680-003 AN - 2005-06680-003 AU - Carter, Jerry W. Jr. ED - Strother, Charles R. ED - Strother, Charles R., (Ed) T1 - The Training Needs of Psychologists in Community Mental Health Programs at State and Local Levels. T2 - Psychology and mental health. Y1 - 1956/// SP - 21 EP - 40 CY - Washington, DC, US PB - American Psychological Association N1 - Accession Number: 2005-06680-003. Partial author list: First Author & Affiliation: Carter, Jerry W. Jr.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20050718. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Community Mental Health; Mental Health Programs; Postgraduate Training; Psychologists; Psychology Education. Minor Descriptor: Clinical Psychologists; Counseling Psychologists; Needs; Primary Mental Health Prevention; School Psychologists. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 20. AB - Notes that essentially all clinical, counseling, and school psychologists already work in a variety of mental health activities; many other psychologists are engaged in training these and other mental health personnel; and still others do a great deal of the research done on mental health problems. And yet, all these efforts are not enough to satisfy society's needs for more psychologists and more psychological knowledge and skills in mental health programs. In order to better appraise the competencies needed of psychologists in community mental health programs, this chapter reviews the organization and scope of activities in such programs, at state and local levels. The author notes that increased public support--as well as increased federal, state and local funds--for expansion of community mental health activities makes it evident that a greatly increased demand for psychologists to staff these programs will soon be felt. Not only will more clinical, counseling, and school psychologists be needed but the emphasis on preventive mental health programs and on the coordination of community resources necessary to accomplish such programs will require that psychologists be prepared to assume new functions. The author concludes by providing a partial list of suggestions of ways in which training institutions might undertake to develop their staffs for making contributions to the growing field of mental health. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - training needs KW - psychologists KW - community mental health programs KW - state & local levels KW - clinical & counseling & school psychologists KW - preventive mental health programs KW - 1956 KW - Community Mental Health KW - Mental Health Programs KW - Postgraduate Training KW - Psychologists KW - Psychology Education KW - Clinical Psychologists KW - Counseling Psychologists KW - Needs KW - Primary Mental Health Prevention KW - School Psychologists KW - 1956 DO - 10.1037/10791-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06680-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - BOOK ID - 1956-08164-000 AN - 1956-08164-000 AU - Clausen, John A. T1 - Sociology and the field of mental health. Y1 - 1956/// CY - New York, NY, US PB - Russell Sage Foundation N1 - Accession Number: 1956-08164-000. Partial author list: First Author & Affiliation: Clausen, John A.; National Institute of Mental Health, Bethesda, Md. Release Date: 19560601. Publication Type: Book (0200). Format Covered: Print. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 62. AB - Some of the present and potential contributions of social science to research and program operations in the mental health field are delineated. Such areas as 'mental health and illness in cultural perspective' and 'research on social and cultural influences' are reviewed. In addition, a broad overview of sociological research brings to our attention the values to be found in such techniques as public opinion surveys designed to bring to light public knowledge and attitudes toward mental health and illness, various applied researches now going on in mental hospitals, and evaluation studies as applied to treatment, control and prevention. Studies in the social structure and function of treatment settings, as well as the effect of mental illness on the patient and his family, are similarly pointed up. 98-item bibliography. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - SOCIOLOGY KW - & MENTAL HEALTH KW - MENTAL HEALTH KW - & SOCIOLOGY KW - BIBLIOGRAPHIES KW - MENTAL KW - SOCIAL PSYCHOLOGY KW - 1956 KW - No terms assigned KW - 1956 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1956-08164-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - BOOK ID - 2009-02921-000 AN - 2009-02921-000 AU - Ulett, George A. AU - Goodrich, D. Wells T1 - A synopsis of contemporary psychiatry. Y1 - 1956/// CY - St Louis, MO, US PB - C V Mosby Co N1 - Accession Number: 2009-02921-000. Partial author list: First Author & Affiliation: Ulett, George A.; Department of Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO, US. Release Date: 20090316. Correction Date: 20110711. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Psychiatry. Minor Descriptor: Diagnosis; Syndromes; Treatment. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 243. AB - This handbook was written to fill the need for a brief, introductory text of psychiatry as a quick reference for psychiatric residents, medical and psychological interns, medical students, nurses, and others whose work in the psychiatric clinic and hospital may be for a brief period of time. The psychiatric house officer who will spend several years training in the field is called upon in the first weeks of his residency both to diagnose and to treat. This handbook is designed to serve as a ready reference during this initial period of specialty training and until he has had sufficient time to become acquainted with more extensive treatises. With these workers in mind, the book has been made small enough to fit in the side pocket of the clinic coat. It has been written also for the general practitioner who is having his attention increasingly directed to the psychological problems of his patients and who must, in view of the shortage of psychiatrists, often provide early care for those of his patients who develop mental illness. In this text theory is kept to a minimum. The material is organized into three general areas: (a) history taking and diagnostic procedures; (b) clinical syndromes; and (c) therapeutic measures. In the Table of Contents, which follows immediately, one who is unfamiliar with the field can find the general area of his interest at the moment, and then focus upon the page or two devoted to material with which he is specifically concerned. In addition, an alphabetized general index is provided at the end of the book. All sections have been made as brief as possible. We have tried throughout to present the eclectic approach to psychiatry that has been fostered through the teachings of Dr. Edwin F. Gildea. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatry KW - diagnostic procedures KW - clinical syndromes KW - therapeutic measures KW - 1956 KW - Psychiatry KW - Diagnosis KW - Syndromes KW - Treatment KW - 1956 DO - 10.1037/13188-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02921-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Adams, Scott T1 - INFORMATION - A NATIONAL RESOURCE. JO - American Documentation JF - American Documentation Y1 - 1956/04// VL - 7 IS - 2 M3 - Article SP - 71 EP - 75 SN - 0096946X AB - Focuses on information resources. Observation on information resources; Definitions of scientific information; Views of documentalists on information resources; Association of information resources with natural resources; Suggestions for organized documentation. KW - INFORMATION resources KW - INFORMATION science KW - DOCUMENTATION KW - NATURAL resources N1 - Accession Number: 16810762; Adams, Scott 1; Affiliations: 1: Librarian, National Institutes of Health, Public Health Service, U. S. Dept. of Health, Education, and Welfare; Issue Info: Apr1956, Vol. 7 Issue 2, p71; Thesaurus Term: INFORMATION resources; Thesaurus Term: INFORMATION science; Thesaurus Term: DOCUMENTATION; Subject Term: NATURAL resources; Number of Pages: 5p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16810762&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Kohn, Melvin L. AU - Williams Jr., Robin M. T1 - SITUATIONAL PATTERNING IN INTERGROUP RELATIONS. JO - American Sociological Review JF - American Sociological Review Y1 - 1956/04// VL - 21 IS - 2 M3 - Article SP - 164 EP - 174 SN - 00031224 AB - There is now abundant research evidence of situational variability in intergroup behavior: an ever-accumulating body of research demonstrates that allegedly prejudiced persons act in a thoroughly egalitarian manner in situations where that is the socially prescribed mode of behavior, and that allegedly unprejudiced persons discriminate in situations where they feel it is socially appropriate to do so. It is also well known that patterns of "appropriateness" in intergroup behavior have been changing with increasing tempo in recent years. The unthinkable of a short time ago has in many areas of life become the commonplace of today. For a brief period the transition from unthinkable to commonplace arouses extreme emotional fervor; but as the new definition of the situation becomes the socially prescribed, the fervor soon diminishes. Unpatterned situations, in which definitions of appropriate conduct are in process of change, occur infrequently, and it is even more infrequent that they occur at the convenience of the research observer. KW - INTERGROUP relations KW - INTERPERSONAL relations KW - SOCIAL interaction KW - EQUALITY KW - SOCIAL attitudes KW - SOCIAL science research N1 - Accession Number: 12786264; Kohn, Melvin L. 1; Williams Jr., Robin M. 2; Affiliations: 1: National Institute of Mental Health; 2: Cornell University; Issue Info: Apr56, Vol. 21 Issue 2, p164; Thesaurus Term: INTERGROUP relations; Thesaurus Term: INTERPERSONAL relations; Subject Term: SOCIAL interaction; Subject Term: EQUALITY; Subject Term: SOCIAL attitudes; Subject Term: SOCIAL science research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 11p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786264&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Deasy, Leila Calhoun T1 - SOCIO-ECONOMIC STATUS AND PARTICIPATION IN THE POLIOMYELITIS VACCINE TRIAL. JO - American Sociological Review JF - American Sociological Review Y1 - 1956/04// VL - 21 IS - 2 M3 - Article SP - 185 EP - 191 SN - 00031224 AB - The relationships between socio-economic status and orientations toward values such as health, cleanliness, and education have been observed in a large number of community studies and attitude surveys by social scientists. Recently attention has been directed to the effect of socio-economic status on types of treatment sought for various illnesses. Independently, practitioners in the field of public health have learned to make reasonably accurate predictions of the amount of co-operation community health programs will receive from various segments of the local population. In general, they seem to anticipate that preventive programs will encounter the greatest opposition in the strata of lower socio-economic status, except where specific vested interests of other groups are involved. An opportunity to analyze responses to a new program which offered the possibility of giving protection against poliomyelitis was provided in the spring of 1954 when the National Foundation for Infantile Paralysis sponsored a large-scale trial of the poliomyelitis vaccine developed by Jonas Salk. The effectiveness of the vaccine could be determined only by its administration to large numbers of people. The vaccine was offered to children in certain grades in selected areas throughout the U. S., on condition that their parents approve their participation. KW - POLIO -- Vaccination KW - HEALTH promotion KW - PUBLIC health KW - ENTEROVIRUS diseases KW - SOCIAL scientists KW - SALK, Jonas, 1914-1995 N1 - Accession Number: 12786267; Deasy, Leila Calhoun 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Apr56, Vol. 21 Issue 2, p185; Subject Term: POLIO -- Vaccination; Subject Term: HEALTH promotion; Subject Term: PUBLIC health; Subject Term: ENTEROVIRUS diseases; Subject Term: SOCIAL scientists; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: SALK, Jonas, 1914-1995; Number of Pages: 7p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12786267&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2013-40817-010 AN - 2013-40817-010 AU - Kohn, Melvin L. AU - Clausen, John A. T1 - Parental authority behavior and schizophrenia. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1956/04// VL - 26 IS - 2 SP - 297 EP - 313 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40817-010. PMID: 13313699 Partial author list: First Author & Affiliation: Kohn, Melvin L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Parent Child Relations; Parental Characteristics; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Apr, 1956. AB - The present paper reports data secured from systematic interviewing of a sample of schizophrenic patients and former patients from a single community, along with data on carefully selected controls for these patients. In addition to our interest in the perception or recollection of parent-child relationships, we have been concerned with social participation or isolation during adolescence, social and residential mobility, and other experiences in the childhood and adolescence of the patients and controls. Our inquiry into family relationships is limited in scope to the two dimensions on which previous investigators have reached the most consistent confusions-authority and affection. Our techniques for eliciting data were simple and, by clinical standards, extremely crude. Despite this crudeness, however, the complementality of our findings to those of investigators who have secured their data from the mothers of schizophrenic patients, and the interrelationships that we have found between social status and the perception of family structure, lead us to hope that presentation of these data will be of value to others seeking to carry out research on this complex problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - parental authority behavior KW - schizophrenia KW - parent-child relationships KW - communities KW - interrelationships KW - 1956 KW - Communities KW - Parent Child Relations KW - Parental Characteristics KW - Schizophrenia KW - 1956 DO - 10.1111/j.1939-0025.1956.tb06179.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40817-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Deasy, Leila Calhoun T1 - Health, Culture and Community: Case Studies of Public Reactions to Health Programs (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1956/06// VL - 21 IS - 3 M3 - Book Review SP - 395 EP - 395 SN - 00031224 AB - Reviews the book "Health, Culture and Community: Case Studies of Public Reactions to Health Programs," edited by Benjamin D. Paul and Walter B. Miller. KW - PUBLIC health KW - NONFICTION KW - PAUL, Benjamin D. KW - MILLER, Walter B. KW - HEALTH, Culture & Community: Case Studies of Public Reactions to Health Programs (Book) N1 - Accession Number: 12772474; Deasy, Leila Calhoun 1; Affiliations: 1: National institute of Mental Health; Issue Info: Jun56, Vol. 21 Issue 3, p395; Subject Term: PUBLIC health; Subject Term: NONFICTION; Reviews & Products: HEALTH, Culture & Community: Case Studies of Public Reactions to Health Programs (Book); NAICS/Industry Codes: 525120 Health and Welfare Funds; People: PAUL, Benjamin D.; People: MILLER, Walter B.; Number of Pages: 2/3p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12772474&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - AU - Bayley, Nancy1 AU - Findley, Warren C.2 AU - Gerberich, J. Raymond3 AU - Justman, Joseph4 AU - Mollenkopf, William G.2 AU - Sells, Saul B.5 AU - Stroud, James B.6 AU - Swineford, Frances2 AU - Symonds, Percival M.7 AU - Wrightstone, J. Wayne8 T1 - Educational Measurements. JO - Review of Educational Research JF - Review of Educational Research J1 - Review of Educational Research PY - 1956/06// Y1 - 1956/06// VL - 26 IS - 3 CP - 3 M3 - Article SP - 268 EP - 291 SN - 00346543 AB - This article presents the contributions of research to tests and measurements in the area of intelligence, aptitude, achievement, personality, interests and attitudes, interests and attitudes, child study technics, and statistical methods related to test construction. Experimentation directed toward applications peculiar to nonverbal tests, in general school practice. It also recognizes verbal group tests influenced by reading proficiency. Understanding of the nature and structure of human abilities. KW - Reading KW - Educational tests & measurements KW - Child development -- Research KW - Ability KW - Personality KW - Child development KW - Comprehension N1 - Accession Number: 18812127; Authors: Bayley, Nancy 1; Findley, Warren C. 2; Gerberich, J. Raymond 3; Justman, Joseph 4; Mollenkopf, William G. 2; Sells, Saul B. 5; Stroud, James B. 6; Swineford, Frances 2; Symonds, Percival M. 7; Wrightstone, J. Wayne 8; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland; 2: Educational Testing Service, Princeton, New Jersey; 3: University of Connecticut, Storrs, Connecticut; 4: Board of Education, New York, New York; 5: U.S.A.F. School of Aviation Medicine, Randolph Air Force Base, San Antonio, Texas; 6: State University of Iowa, Iowa City, Iowa; 7: Teachers College, Columbia University, New York, New York; 8: Chairman, Board of Education, New York, New York; Subject: Educational tests & measurements; Subject: Child development -- Research; Subject: Ability; Subject: Personality; Subject: Child development; Subject: Comprehension; Subject: Reading; Number of Pages: 24p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=18812127&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - JOUR ID - 2012-23199-004 AN - 2012-23199-004 AU - Clausen, John A. AU - Linn, Erwin L. T1 - Public reaction to a severe polio outbreak in three Massachusetts communities. JF - Social Problems JO - Social Problems JA - Soc Probl Y1 - 1956/07// VL - 4 IS - 1 SP - 40 EP - 51 CY - US PB - University of California Press SN - 0037-7791 SN - 1533-8533 N1 - Accession Number: 2012-23199-004. Partial author list: First Author & Affiliation: Clausen, John A.; Laboratory of Socio-environmental Studies, National Institute of Mental Health, MD, US. Other Publishers: Oxford University Press. Release Date: 20130617. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Epidemics; Public Opinion; Society; Urban Environments. Minor Descriptor: Poliomyelitis. Classification: Social Processes & Social Issues (2900). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jul, 1956. AB - This article presents a study which aims to examine the reactions of the public to a severe polio outbreak in three Massachusetts communities. The respondents of the study were asked how one can tell when a disease has reached an epidemic stage. The data which have been presented bear on two aspects of response to the threat of a polio epidemic in three separate communities within an urban area, communications about the disease threat and appropriate actions toward it, as carried in the local press, and individual perceptions, attitudes and actions relative to that threat on the part of the mothers of young children. The study concluded that the effectiveness of any society's efforts to cope with disease or threats to health clearly depends not only on the availability of scientific knowledge underlying techniques of treatment and of disease control, but also upon the readiness of the population to utilize such knowledge. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - polio KW - epidemics KW - urban areas KW - social efforts KW - public reactions KW - communities KW - 1956 KW - Communities KW - Epidemics KW - Public Opinion KW - Society KW - Urban Environments KW - Poliomyelitis KW - 1956 U1 - Sponsor: Committee on Disaster Studies. Recipients: No recipient indicated DO - 10.2307/798566 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2012-23199-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05944-021 AN - 2006-05944-021 AU - Kendig, Isabelle V. T1 - An Adolescent Topsy. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1956/08// VL - 1 IS - 8 SP - 246 EP - 246 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05944-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Community Mental Health; Community Services. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Kotinsky, Ruth (Ed); Witmer, Helen L. (Ed). Community Programs for Mental Health=Cambridge, Mass.: Harvard University Press, 1955. Pp. xix + 362. $5.00; 1955. Page Count: 1. Issue Publication Date: Aug, 1956. AB - Reviews the book, Community Programs for Mental Health edited by Ruth Kotinsky and Helen L. Witmer (see record [rid]1956-04525-000[/rid]). This collection of papers is best understood in historical perspective. The present volume reflects the remarkable development of the mental health movement, as it is now termed, since that first decade. It is most hopeful that the mental health movement has now achieved that degree of self-awareness that inspires its leaders to seek to clarify its fundamental tenets and practices. The half dozen papers presented here raise, however, many questions and offer few answers. The cause of mental illness is still insufficiently understood, there is no generally accepted definition of mental health, and no 'core curriculum' of principles upon which to base action. While the symposium as a whole will prove thought-provoking to the layman interested in mental health, its challenge is to professional workers responsible for shaping and directing this lusty, adolescent movement. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health movement KW - adolescent movement KW - community programs KW - mental health KW - 1956 KW - Adolescent Development KW - Community Mental Health KW - Community Services KW - 1956 U2 - Kotinsky, Ruth (Ed); Witmer, Helen L. (Ed). (1955); Community Programs for Mental Health; Cambridge, Mass.: Harvard University Press, 1955. Pp. xix + 362. $5.00 DO - 10.1037/005399 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05944-021&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05946-011 AN - 2006-05946-011 AU - Kelman, Herbert C. T1 - Empathy Is Not Enough. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1956/10// VL - 1 IS - 10 SP - 299 EP - 300 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05946-011. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kelman, Herbert C.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Empathy; Family Relations; Personality Development; Social Skills; Interpersonal Relationships. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Foote, Nelson N.; Cottrell, Leonard S. Jr. Identity and Interpersonal Competence: A New Direction in Family Research=Chicago: University of Chicago Press, 1955. Pp. ix + 305. $5.00; 1955. Page Count: 2. Issue Publication Date: Oct, 1956. AB - Reviews the book, Identity and Interpersonal Competence: A New Direction in Family Research by Nelson N. Foote and Leonard S. Cottrell, Jr. (see record [rid]1956-02753-000[/rid]). The bulk of the book is devoted to the development of three interrelated sets of criteria: (1) criteria for evaluating personality development in family members, (2) criteria for evaluating family agencies (and families) in terms of their readiness to undertake deliberate, planned programs designed to enhance personality development, and (3) criteria for evaluating research programs in terms of the likelihood that they will produce results that are generalizable and usable by families and agencies The desirability of democratic planning in the operations of individuals, agencies, and research programs is the common thread that runs through all three of these sets of criteria. The authors' central concept for personality development is interpersonal competence. They list six components of interpersonal competence-health, intelligence, empathy, autonomy, judgment, and creativity-all of which are viewed as capacities needed by the individual for effective handling of his interpersonal relations. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - personality development KW - family agencies KW - interpersonal relations KW - interpersonal competence KW - health KW - 1956 KW - Empathy KW - Family Relations KW - Personality Development KW - Social Skills KW - Interpersonal Relationships KW - 1956 U2 - Foote, Nelson N.; Cottrell, Leonard S. Jr. (1955); Identity and Interpersonal Competence: A New Direction in Family Research; Chicago: University of Chicago Press, 1955. Pp. ix + 305. $5.00 DO - 10.1037/005436 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05946-011&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Shock, Nathan W. T1 - Age changes in some physiologic processes. JO - Geriatrics JF - Geriatrics Y1 - 1957/01// VL - 12 IS - 1 M3 - Article SP - 40 EP - 48 SN - 0016867X N1 - Accession Number: 17414914; Shock, Nathan W. 1,2; Source Information: Jan1957, Vol. 12 Issue 1, p40; Number of Pages: 9p; Illustrations: 15 Graphs; Document Type: Article; Full Text Word Count: 3952 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17414914&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2013-39110-005 AN - 2013-39110-005 AU - Gordon, Gene AU - Siegel, Leonard T1 - The evolution of a program of individual psychotherapy for children with aggressive acting-out disorders in a new residential treatment unit. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1957/01// VL - 27 IS - 1 SP - 59 EP - 68 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39110-005. PMID: 13402870 Partial author list: First Author & Affiliation: Gordon, Gene; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Acting Out; Antisocial Behavior; Individual Psychotherapy; Residential Care Institutions; Treatment Duration. Minor Descriptor: Aggressive Behavior; Patients. Classification: Behavior Disorders & Antisocial Behavior (3230); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Page Count: 10. Issue Publication Date: Jan, 1957. AB - This article provides an overview of a program of individual psychotherapy for children with aggressive acting-out disorders in a new residential treatment unit of the Program of Individual Psychotherapy in the Laboratory of Child Research at the National Institutes of Health. This Laboratory was organized to investigate the residential treatment of children with aggressive acting-out disorders. Toward the end of the third month, the authors admitted the first patient group of five boys ranging in age from 9 to 13.5. These boys were selected for study from other institutions where they had been admitted for such complaints as fire-setting, vandalism, stealing, truancy, and severe temper tantrums and planned to keep them at least three months and no longer than eight months. The impact of this first disturbed group was profound. The second patient group was composed of the three youngest boys from the first patient group and three new patients. This second group ranged in age from 9 to 12-in contrast to the first group which ranged from 9 to 13.5. The patients in this second group had manifested much the same kind of antisocial behavior as their predecessors. The third patient group differ from the earlier patient groups in two important respects. The children were younger ranging in age from 8 through 10 and with this group, the authors commited themselves to long-term treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - aggressive acting-out disorders KW - antisocial behavior KW - long term treatment KW - patient groups KW - residential treatment KW - individual psychotherapy KW - 1957 KW - Acting Out KW - Antisocial Behavior KW - Individual Psychotherapy KW - Residential Care Institutions KW - Treatment Duration KW - Aggressive Behavior KW - Patients KW - 1957 DO - 10.1111/j.1939-0025.1957.tb05200.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39110-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39110-006 AN - 2013-39110-006 AU - Bloch, Donald A. AU - Silber, Earle T1 - The role of the administrator in relation to individual psychotherapy in a residential treatment setting. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1957/01// VL - 27 IS - 1 SP - 69 EP - 74 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39110-006. PMID: 13402871 Partial author list: First Author & Affiliation: Bloch, Donald A.; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Individual Psychotherapy; Residential Care Institutions; Role Playing; Health Personnel. Minor Descriptor: Intensive Care. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 6. Issue Publication Date: Jan, 1957. AB - This article discusses the role of the administrator in relation to individual psychotherapy in a residential treatment setting. The article focus on his role as it bears on a program of intensive individual psychotherapy carried on concurrently with the milieu treatment. The administrator performs the initial psychiatric examination and participates in the child’s preadmission visits to the living unit. He has an opportunity in these contacts to communicate the broad outlines of his functions as well as those of other significant people. Moreover, he continues the process, already begun by the referring agency, of defining with the child the problem areas in his living which have led to his institutionalization. With regard to individual psychotherapy, certain features of the administrator’s role may be emphasized. In part because of his authoritative position, and in part because he functions as the psychiatrist in the intake interview, he becomes, from the very first moment, in the eyes of the child, the responsible sponsor of treatment. That is, he defines problem areas and initiates a corrective regimen. This includes the sponsorship of individual psychotherapy. The administrator’s specific functions in the treatment process are derived from his unique position in the social structure of the residential setting. His position as a key person in the policy making and communication network on the unit and as an authority figure in the child’s life can be used therapeutically in combining milieu therapy with intensive individual psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - residential treatment setting KW - milieu therapy KW - intensive individual psychotherapy KW - administrator roles KW - 1957 KW - Individual Psychotherapy KW - Residential Care Institutions KW - Role Playing KW - Health Personnel KW - Intensive Care KW - 1957 DO - 10.1111/j.1939-0025.1957.tb05201.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39110-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-03890-001 AN - 1959-03890-001 AU - Ader, Robert AU - Clink, Daniel W. T1 - Effects of chlorpromazine on the acquisition and extinction of an avoidance response in the rat. JF - The Journal of Pharmacology and Experimental Therapeutics JO - The Journal of Pharmacology and Experimental Therapeutics JA - J Pharmacol Exp Ther Y1 - 1957/// VL - 121 SP - 144 EP - 148 CY - US PB - American Society for Pharmacology & Experimental Therapeutics ASPET SN - 0022-3565 SN - 1521-0103 N1 - Accession Number: 1959-03890-001. PMID: 13481837 Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Ader, Robert; National Institutes of Health. Release Date: 19590201. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 5. Issue Publication Date: 1957. AB - Rats receiving 1.5 or 3.0 mgm/kgm chlorpromazine were compared with saline controls for acquisition and extinction of avoidance in a modified Miller-Mowrer shuttlebox. The chlorpromazine animals required significantly more trials than the controls to meet the criterion for avoidance. 'Without regard for the conditions under which the response was acquired, chlorpromazine (1.5 mgm/kgm) decreased resistance to extinction. Whereas there were no differences in comparable groups under the smaller dosage, 3.0 mgm/kgm of chlorpromazine decreased the resistance of animals having acquired the response under placebo.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - EXTINCTION KW - AVOIDANCE KW - RESPONSE KW - RAT KW - DRUGS KW - CHLORPROMAZINE KW - AVOIDANCE LEARNING KW - CHLORPROMAZINE & KW - TREATMENT METHODS KW - 1957 KW - No terms assigned KW - 1957 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-03890-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-05927-001 AN - 1959-05927-001 AU - Hollister, William G. T1 - The risks of freedom-giving group leadership. JF - Mental Hygiene. New York JO - Mental Hygiene. New York Y1 - 1957/// VL - 41 SP - 238 EP - 244 N1 - Accession Number: 1959-05927-001. PMID: 13418332 Partial author list: First Author & Affiliation: Hollister, William G.; National Institute of Mental Health, Bethesda, Md. Release Date: 19590301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 7. Issue Publication Date: 1957. AB - Leadership is not without its hazards, especially in dynamic group activities. Some of these hazards are delineated and discussed. The values in the leadership role are great regardless of the fact that its risks are manifold. The leader gains his profits from knowledge of the behavioral-patterns of the component elements of the group. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - LEADERSHIP KW - HAZARDS & GAINS OF KW - SOCIAL PSYCHOLOGY KW - 1957 KW - No terms assigned KW - 1957 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-05927-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-01281-001 AN - 1959-01281-001 AU - Kataguchi, Yasufumi T1 - The development of the Rorschach test in Japan. JF - Journal of Projective Techniques JO - Journal of Projective Techniques Y1 - 1957/// VL - 21 SP - 258 EP - 260 N1 - Accession Number: 1959-01281-001. PMID: 13463809 Partial author list: First Author & Affiliation: Kataguchi, Yasufumi; National Institute of Mental Health, Japan. Release Date: 19590101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 3. Issue Publication Date: 1957. AB - The writer reviews the history of the Rorschach in Japan, showing the number of papers on the Rorschach that have been read each year since 1950 at the Japanese Psychological Association. Also presented are complete bibliographies of Japanese books and articles on the Rorschach. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - RORSCHACH TEST KW - JAPAN KW - CULTURES KW - BIBLIOGRAPHIES KW - RORSCHACH IN JAPAN KW - DIAGNOSIS & EVALUATION KW - 1957 KW - No terms assigned KW - 1957 DO - 10.1080/08853126.1957.10380781 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-01281-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-00495-001 AN - 1959-00495-001 AU - Botwinick, Jack AU - Jerome, Edward A. AU - Birren, James E. AU - Brinley, Joseph F. T1 - Light aversion motivation in psychologic studies of aging in rats. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1957/// VL - 12 SP - 296 EP - 299 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1959-00495-001. PMID: 13463300 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19590101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 4. Issue Publication Date: 1957. AB - For aging studies of rat behavior, a technique was tested for its suitability. Two groups of Sprague-Dawley rats of approximately 1 and 2 years of age were statistically similar with respect to several criteria of averting light. It was concluded that the technique 'is suitable for age comparisons in rat learning, at least within the age period of 1 or 2 years.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - RAT KW - HOODED KW - AGING STUDY KW - LIGHT AVERSION TECHNIQUE KW - AVOIDANCE LEARNING KW - AGE OF RAT KW - AGE KW - AVOIDANCE LEARNING & KW - RESPONSE PROCESSES KW - 1957 KW - No terms assigned KW - 1957 DO - 10.1093/geronj/12.3.296 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00495-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-00924-001 AN - 1959-00924-001 AU - Botwinick, Jack AU - Brinley, Joseph F. AU - Birren, James E. T1 - Set in relation to age. JF - Journal of Gerontology JO - Journal of Gerontology JA - J Gerontol Y1 - 1957/// VL - 12 SP - 300 EP - 305 CY - US PB - Gerontological Society of America SN - 0022-1422 N1 - Accession Number: 1959-00924-001. PMID: 13463301 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Botwinick, Jack; National Institute of Mental Health, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19590101. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 6. Issue Publication Date: 1957. AB - Two age groups were compared with respect to set as it is defined by the functional relation between reaction time and an irregularly presented series of preparatory intervals. The largest age differences in reaction time were with the shortest or shorter intervals. This suggested that the older group either required more time for preparation or required more time to overcome the effects of an overestimated interval. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - SET KW - & AGE KW - AGE KW - & SET IN REACTION TIME KW - MATURITY & OLD AGE KW - 1957 KW - No terms assigned KW - 1957 DO - 10.1093/geronj/12.3.300 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00924-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-03929-001 AN - 1959-03929-001 AU - Day, Juliana T1 - The role and reaction of the psychiatrist in LSD therapy. JF - Journal of Nervous and Mental Disease JO - Journal of Nervous and Mental Disease JA - J Nerv Ment Dis Y1 - 1957/// VL - 125 SP - 437 EP - 437 CY - US PB - Lippincott Williams & Wilkins SN - 0022-3018 SN - 1539-736X N1 - Accession Number: 1959-03929-001. PMID: 13481751 Partial author list: First Author & Affiliation: Day, Juliana; National Institute of Mental Health. Release Date: 19590201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 1. Issue Publication Date: 1957. AB - Observations on 2 borderline neurotics, who received LSD from the therapist, convince her that LSD sets in motion certain processes within the patient which are out of the therapist's and the patient's control. While this drug is given in order to establish a better therapeutic relationship, its secondary effects can defeat the very purpose for which it was administered. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PSYCHOTHERAPY KW - LYSERGIC ACID KW - IN NEUROSIS KW - NEUROSIS KW - & PSYCHOTHERAPY ON KW - DRUGS KW - DIETHYLAMIDE KW - TREATMENT METHODS KW - 1957 KW - No terms assigned KW - 1957 DO - 10.1097/00005053-195707000-00016 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-03929-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-01643-001 AN - 1959-01643-001 AU - Kramer, Morton AU - Person, Philip H. Jr. AU - Tarjan, George AU - Morgan, Richard AU - Wright, Stanley W. T1 - A method for determination of probabilities of stay, release, and death, for patients admitted to a hospital for the mentally deficient: The experience of Pacific State Hospital during the period 1948-1952. JF - American Journal of Mental Deficiency JO - American Journal of Mental Deficiency JA - Am J Ment Defic Y1 - 1957/// VL - 62 SP - 481 EP - 495 CY - US PB - American Assn on Mental Retardation SN - 0002-9351 N1 - Accession Number: 1959-01643-001. PMID: 13469851 Other Journal Title: American Journal on Intellectual and Developmental Disabilities; American Journal on Mental Retardation. Partial author list: First Author & Affiliation: Kramer, Morton; National Institute of Mental Health, Public Health Service, Bethesda, Md. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19590101. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 15. Issue Publication Date: 1957. AB - A series of analyses is presented demonstrating 'a method for determining the probability of release, death and retention for patients admitted to a hospital for the mentally retarded.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - MENTAL RETARDATION KW - HOSPITAL STAY KW - ANALYSIS KW - HOSPITAL KW - FOR MENTAL DEFECTIVES KW - RETENTION PROBABILITY KW - MENTAL DEFICIENCY KW - 1957 KW - No terms assigned KW - 1957 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-01643-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-00538-001 AN - 1959-00538-001 AU - Mirsky, Allan F. AU - Rosvold, H. Enger AU - Pribram, Karl H. T1 - Effects of cingulectomy on social behavior in monkeys. JF - Journal of Neurophysiology JO - Journal of Neurophysiology JA - J Neurophysiol Y1 - 1957/// VL - 20 SP - 588 EP - 601 CY - US PB - American Physiological Society SN - 0022-3077 SN - 1522-1598 N1 - Accession Number: 1959-00538-001. PMID: 13476215 Partial author list: First Author & Affiliation: Mirsky, Allan F.; National Institute of Mental Health, Bethesda, Maryland. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 14. Issue Publication Date: 1957. AB - 'Bilateral cingular gyrus ablations were performed in five young Macaca mulatta monkeys, after systematic observations of their behavior in response to man (individual-cage situation) and to other animals in a social colony (group-cage situation).' The change in behavior following the ablation is described. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - SOCIAL BEHAVIOR KW - & CINGULECTOMY KW - MONKEY KW - CINGULECTOMY KW - & SOCIAL BEHAVIOR KW - CINGULATE GYRUS KW - LESION IN KW - BEHAVIOR & KW - RESPONSE PROCESSES KW - 1957 KW - No terms assigned KW - 1957 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00538-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-00250-001 AN - 1959-00250-001 AU - Mishkin, Mortimer T1 - Effects of small frontal lesions on delayed alternation in monkeys. JF - Journal of Neurophysiology JO - Journal of Neurophysiology JA - J Neurophysiol Y1 - 1957/// VL - 20 SP - 615 EP - 622 CY - US PB - American Physiological Society SN - 0022-3077 SN - 1522-1598 N1 - Accession Number: 1959-00250-001. PMID: 13476217 Partial author list: First Author & Affiliation: Mishkin, Mortimer; National Institute of Mental Health, Bethesda, Md. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Physiological Psychology & Neuroscience (2500). Page Count: 8. Issue Publication Date: 1957. AB - 'To help define the cortical area focally concerned in delayed-response types of functions in the monkey, ten animals were given various subtotal lesions of frontal granular cortex and tested for the retention of a delayed-alternation habit. The four animals that received lesions of the midlateral cortex performed more poorly than the animals with other lesions. In one instance a midlateral lesion produced a deficit that was as severe and as longlasting as that following total anterior frontal ablation. The results are discussed in relation to possible neural mechanisms for the mediation of delayed-responses in the monkey.' 20 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - MONKEY KW - BRAIN LESION KW - & DELAYED RESPONSE KW - DELAYED RESPONSE & KW - NERVOUS SYSTEM KW - 1957 KW - No terms assigned KW - 1957 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00250-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-00494-001 AN - 1959-00494-001 AU - Blough, Donald S. T1 - Spectral sensitivity in the pigeon. JF - Journal of the Optical Society of America JO - Journal of the Optical Society of America JA - J Opt Soc Am Y1 - 1957/// VL - 47 SP - 827 EP - 833 CY - US PB - Optical Society of America SN - 0030-3941 N1 - Accession Number: 1959-00494-001. PMID: 13463678 Other Journal Title: Journal of the Optical Society of America, A, Optics, Image & Science; Journal of the Optical Society of America, A, Optics, Image Science & Vision. Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, National Institutes of Health, Bethesda, Md. Release Date: 19590101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 7. Issue Publication Date: 1957. AB - 'Measurements of light- and dark-adapted absolute thresholds were obtained from three pigeons at 15 wavelengths ranging from 380 mμ to 700mμ. Pecking responses caused a stimulus patch to fluctuate in intensity up and down across the pigeon's threshold, and a record of the intensity provided the sensitivity data. The sensitivity of the birds was followed throughout a period of 80 min. following a standard pre-exposure to white light. Four complete dark adaptation curves were obtained from each bird at each wavelength. Spectral sensitivity functions derived from these curves place the photopic maximum at 560-580 mμ, and the scotopic maximum at about 500 mμ. The scotopic function is fitted closely by aphakic human data. The photopic function shows inflections that may be related to similar inflections in corresponding human curves. The functions are quite similar to those found in electrophysiological studies of the pigeon eye. They also correspond rather well to the absorption spectra of chicken rhodopsin and iodopsin.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PIGEON KW - SPECTRAL SENSITIVITY KW - LIGHT ADAPTATION KW - IN PIGEON KW - DARK ADAPTATION KW - RESPONSE PROCESSES KW - VISION KW - 1957 KW - No terms assigned KW - 1957 DO - 10.1364/JOSA.47.000827 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-00494-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Perry, Stewart E. T1 - Integrating Sociological and Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1957/02// VL - 22 IS - 1 M3 - Book Review SP - 113 EP - 114 SN - 00031224 AB - Reviews the book "Integrating Sociological and Psychoanalytic Concepts: An Exploration in Child Psychotherapy," by Otto Pollak. KW - CHILD psychotherapy KW - NONFICTION KW - POLLAK, Otto KW - INTEGRATING Sociological & Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book) N1 - Accession Number: 12771427; Perry, Stewart E. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Feb57, Vol. 22 Issue 1, p113; Subject Term: CHILD psychotherapy; Subject Term: NONFICTION; Reviews & Products: INTEGRATING Sociological & Psychoanalytic Concepts: An Exploration in Child Psychotherapy (Book); People: POLLAK, Otto; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12771427&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-05951-019 AN - 2006-05951-019 AU - Birren, James E. T1 - Aging Comes of Age. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1957/03// VL - 2 IS - 3 SP - 82 EP - 82 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05951-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Birren, James E.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gerontology; Human Development; Physiological Aging. Classification: Gerontology (2860). Population: Human (10). Reviewed Item: Anderson, John E. (Ed). Psychological Aspects of Aging=(Proceedings of a Conference on Planning Research, Bethesda, Md., 24-27 April 1955.) Washington, D. C: American Psychological Association, 1956. Pp. viii + 323. $2.00; 1956. Page Count: 1. Issue Publication Date: Mar, 1957. AB - Reviews the book, Psychological Aspects of Aging by John E. Anderson (Ed.) (1956). This book will answer the question' 'What is the psychology of aging?' It is the only existing comprehensive summary of the literature and research issues, and its publication in such a usable form is a creditable achievement. One gathers from the present proceedings that many of the participants regarded the study of aging as one of the vantage points from which a scientist may operate in exploring the organization of function. The presence in the conference of persons who had done most of their research in the field of child development is significant. The many questions raised by this conference are relevant to the practical problems of older people. Certainly a service has been done for science by the present conference that asks what we know and do not know about aging and then puts the discussion into print. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychological aspects KW - aging KW - older people KW - human development KW - 1957 KW - Gerontology KW - Human Development KW - Physiological Aging KW - 1957 U2 - Anderson, John E. (Ed). (1956); Psychological Aspects of Aging; (Proceedings of a Conference on Planning Research, Bethesda, Md., 24-27 April 1955.) Washington, D. C: American Psychological Association, 1956. Pp. viii + 323. $2.00 DO - 10.1037/005499 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05951-019&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05952-016 AN - 2006-05952-016 AU - Hill, Harris E. T1 - How to Help the Addict. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1957/04// VL - 2 IS - 4 SP - 113 EP - 114 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05952-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hill, Harris E.; National Institute of Mental Health, Lexington, KY, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinics; Drug Addiction; Drug Rehabilitation; Narcotic Drugs. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Nyswander, Marie. The Drug Addict as a Patient=New York: Grune & Stratton, 1956. Pp. xi + 179. $4.50; 1956. Page Count: 2. Issue Publication Date: Apr, 1957. AB - Reviews the book, The Drug Addict as a Patient by Marie Nyswander (see record [rid]1956-08359-000[/rid]). The author presents a well-written account of published findings and personal opinions that covers many disciplines. Author presents it in a style which is sufficiently popular to attract both layman and physician. Addiction is here characterized as a 'distinct medical entity' which is 'pandemic.' The author's arguments for a reconsideration of the addict's plight and for devising better methods for his rehabilitation present the strongest, if not the most valid, part of the book. Tone, purpose, and fact are well blended here to depict narcotic addicts as persons who are terribly misunderstood and mistreated, and who should be maintained on drugs dispensed by government clinics while their rehabilitation is attempted. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - narcotic addicts KW - rehabilitation KW - drug abuse KW - government clinics KW - 1957 KW - Clinics KW - Drug Addiction KW - Drug Rehabilitation KW - Narcotic Drugs KW - 1957 U2 - Nyswander, Marie. (1956); The Drug Addict as a Patient; New York: Grune & Stratton, 1956. Pp. xi + 179. $4.50 DO - 10.1037/005515 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05952-016&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39302-014 AN - 2013-39302-014 AU - Kaplan, David M. AU - Goodrich, D. Wells T1 - A formulation for interpersonal anger. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1957/04// VL - 27 IS - 2 SP - 387 EP - 395 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39302-014. PMID: 13424647 Partial author list: First Author & Affiliation: Kaplan, David M.; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Acting Out; Aggressive Behavior; Anger; Emotions; Interpersonal Interaction. Minor Descriptor: Responses. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 1957. AB - This article presents a systematic way by which interpersonal anger is studied. The data was gathered on the immediate precipitating factors leading to the expression of anger, on the nature and psychological meaning of anger in these interactions and on any distinctive aspects of these anger interactions which relate to the problems of the aggressive acting-out child. The objective in analyzing these interactions was to formulate psychologically meaningful descriptions which would include the subjective aspects of the individual participant’s experience in these interactions. An analysis of this anger response suggests that it consists of four conceptually separate phases or parts: cognitive, physiological, emotional, and conative. From a theoretical point of view anger is not conceived here simply as an emotion or a feeling experience alone. It is a complex that includes cognitive, emotional, physiological, and conative processes, all of which are intimately interwoven and inseparable from one another. Anger does not occur as an invariant response to frustration but depends upon the individual’s interpretation of the behavior of others. Once anger does occur, the interpretation is made implicitly that the behavior of the other is intentionally and unjustifiably hostile and the other is held accountable for his actions. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - aggressive child acting out KW - anger interactions KW - anger response KW - conative processes KW - feeling experience KW - interpersonal anger KW - 1957 KW - Acting Out KW - Aggressive Behavior KW - Anger KW - Emotions KW - Interpersonal Interaction KW - Responses KW - 1957 DO - 10.1111/j.1939-0025.1957.tb05502.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39302-014&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39302-015 AN - 2013-39302-015 AU - Siegel, Leonard T1 - Case study of a thirteen-year-old fire-setter: A catalyst in the growing pains of a residential treatment unit. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1957/04// VL - 27 IS - 2 SP - 396 EP - 410 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39302-015. Partial author list: First Author & Affiliation: Siegel, Leonard; Laboratory of Child Research, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting in a Session on "Residential Treatment", 1955. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Antisocial Behavior; Behavior Disorders; Residential Care Institutions; Treatment Facilities. Classification: Behavior Disorders & Antisocial Behavior (3230); Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Inpatient (50). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Clinical Case Study. References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1957. AB - This article presents a case report of a 13-year old boy Freddy, who had been picked up by the police for setting fires. He toured the neighborhood with the fire marshals and with little reluctance pointed out the places where he had set several dozen small fires The mother, weakly supported by the father, fought every step in the subsequent legal preliminaries to residential treatment of the child. The lengthy court trials with cross-examinations of the psychiatrists in the presence of the child and his parents, a prolonged stay in the overcrowded detention home, and a period of observation on the adult ward of a psychiatric hospital seemed to aid in cementing the bonds of the pre-existent ambivalent alliance between the patient and his mother. The data available on admission indicated that fire-setting was only one aspect of a broad spectrum of disturbed behavior which included a life history of soiling, several episodes of running away, difficulties in school, truancy, nightmares, and temper tantrums. Freddy was treated by utilizing the therapeutic technique of playroom psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - residential treatment KW - treatment units KW - behavior disorders KW - antisocial behavior KW - 1957 KW - Antisocial Behavior KW - Behavior Disorders KW - Residential Care Institutions KW - Treatment Facilities KW - 1957 DO - 10.1111/j.1939-0025.1957.tb05503.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39302-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05953-005 AN - 2006-05953-005 AU - Dittmann, Allen T. T1 - Sullivan's Two Premises. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1957/05// VL - 2 IS - 5 SP - 127 EP - 129 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05953-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Allen T.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Diagnosis; Mental Disorders; Psychiatry; Symptoms. Minor Descriptor: Philosophies. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Sullivan, Harry Stack; Perry, Helen Swick (Ed); Gawel, Mary Ladd (Ed); Gibbon, Martha (Ed). Clinical Studies in Psychiatry=New York: W. W. Norton, 1956. Pp. xiv + 386. $5.50; 1956. Page Count: 3. Issue Publication Date: May, 1957. AB - Reviews the book, Clinical Studies in Psychiatry by Helen Swick Perry (Ed.), Mary Ladd Gawel, and Martha Gibbon (see record [rid]1956-07384-000[/rid]). This book is most informative in demonstrating the practical effects of Sullivan's theoretical contributions. Like many books called 'clinical psychiatry,' the first half deals with 'symptoms,' how to recognize them and what they mean, and the second takes up the diagnostic entities. Viewed as an advanced text in psychiatry (his audience had already had considerable training), the book is confusingly titled. It contains no 'studies' but is rather a statement of a very experienced and independently thinking psychiatrist's clinical philosophy. In another sense the book is really a text on schizophrenia. Though nicely turned and perhaps appealing to a lecture audience, they require extra work of the reading audience. One could say that Sullivan's philosophy has become psychiatric currency and that the publication of these old lectures serves little purpose. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - clinical studies KW - psychiatry KW - mental disorders KW - symptoms KW - diagnosis KW - Sullivans philosophy KW - 1957 KW - Clinical Psychology KW - Diagnosis KW - Mental Disorders KW - Psychiatry KW - Symptoms KW - Philosophies KW - 1957 U2 - Sullivan, Harry Stack; Perry, Helen Swick (Ed); Gawel, Mary Ladd (Ed); Gibbon, Martha (Ed). (1956); Clinical Studies in Psychiatry; New York: W. W. Norton, 1956. Pp. xiv + 386. $5.50 DO - 10.1037/005635 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05953-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39298-021 AN - 2013-39298-021 AU - Kramer, Morton T1 - Concepts in establishing mental health clinic reporting: Workshop report. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1957/07// VL - 27 IS - 3 SP - 643 EP - 645 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39298-021. PMID: 13444453 Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Concept Formation; Data Collection; Psychiatric Clinics. Minor Descriptor: Mental Health; Population. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 3. Issue Publication Date: Jul, 1957. AB - The primary workshop objective was the review of needs and goals of data collection from mental health clinics at clinic, city, state and national levels and how the current reporting program is meeting these needs. The author outlined briefly the background of the national clinic reporting program and stated as its goal the collection of some basic facts on the outpatient psychiatric clinic population and clinic services. The author pointed out some of the problems in data collection due to the large number and variety of clinics in the country and the complexity of services provided. The author also emphasized the selective nature of the clinic population and that care must be exercised in drawing conclusions on the characteristics of the entire mentally ill population from a study of psychiatric clinic and mental hospital patients only. Of prime importance in the conceptualization of a mental health clinic reporting program is the recognition of some differences between needs for statistical information at clinic or worker levels and at city, state and national levels. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health clinics KW - data collection KW - conceptualization KW - psychiatric clinic populations KW - 1957 KW - Concept Formation KW - Data Collection KW - Psychiatric Clinics KW - Mental Health KW - Population KW - 1957 DO - 10.1111/j.1939-0025.1957.tb05529.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39298-021&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-02996-001 AN - 1959-02996-001 AU - Rheingold, Harriet L. AU - Hess, Eckhard H. T1 - The chick's 'preference' for some visual properties of water. JF - Journal of Comparative and Physiological Psychology JO - Journal of Comparative and Physiological Psychology JA - J Comp Physiol Psychol Y1 - 1957/10// VL - 50 IS - 5 SP - 417 EP - 421 CY - US PB - American Psychological Association SN - 0021-9940 N1 - Accession Number: 1959-02996-001. PMID: 13481175 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Rheingold, Harriet L.; National Institute of Mental Health. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 19590201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Preferences; Visual Perception. Minor Descriptor: Chickens; Water Intake. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 1957. Copyright Statement: American Psychological Association. 1957. AB - At 3 days of age 2 groups of chicks were tested for preference when an array of 6 substances was presented. One group had no prior experience with food or water, while the other had been given them from birth. The distribution of responses by both groups was similar, the order of preference being: mercury, plastic, blue water, water, metal, and red water. 'Although no clear evidence of the propotency of any of the visual attributes of water was demonstrated, it seems probable that attractiveness to the chick lies in a combination of a bright reflecting surface and the movement of the stimulus.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - visual properties KW - visual attributes KW - chicks KW - water KW - 1957 KW - Preferences KW - Visual Perception KW - Chickens KW - Water Intake KW - 1957 DO - 10.1037/h0046108 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-02996-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - NEWS AU - Hunt, G. Halsey T1 - The key role of the physician in geriatric research. JO - Geriatrics JF - Geriatrics Y1 - 1957/11// VL - 12 IS - 11 M3 - Editorial SP - 679 EP - 681 SN - 0016867X N1 - Accession Number: 17775882; Hunt, G. Halsey 1; Source Information: Nov1957, Vol. 12 Issue 11, p679; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1637 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17775882&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2006-05957-019 AN - 2006-05957-019 AU - Kendig, Isabelle V. T1 - The Un-Merry Widow. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1957/11// VL - 2 IS - 11 SP - 290 EP - 291 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05957-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adjustment; Counselors; Marriage; Widows. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Langer, Marion. Learning to Live as a Widow=New York: Julian Messner, 1957. Pp. 255. $3.95; 1957. Page Count: 2. Issue Publication Date: Nov, 1957. AB - Reviews the book, Learning to Live as a Widow by Marion Langer (see record [rid]1957-04558-000[/rid]). The curious thing about this book is that its counterpart, Learning to Live as a Widower, is unlikely ever to be written. Yet the problems dealt with here could as appropriately be treated from the correlative point of view with perhaps two exceptions-Handling the Purse Strings and You as a 'Working Man.' Otherwise, the grief experienced in the loss of a wife and the necessity to deal with the deep feelings aroused, the later need for meeting eligible, single women and, finally, for remarriage are fundamentally the same. Dr. Langer discusses is the widow's feeling of inferiority in practically all situations but especially in those involving normal, social interactions and work adjustment. In general, however, the author's prescription for widows, as for any emotionally disturbed person, is psychologically sound. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - widows KW - marriage counselors KW - marriage KW - 1957 KW - Adjustment KW - Counselors KW - Marriage KW - Widows KW - 1957 U2 - Langer, Marion. (1957); Learning to Live as a Widow; New York: Julian Messner, 1957. Pp. 255. $3.95 DO - 10.1037/005676 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05957-019&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - Gen ID - 9999-28527-000 AN - 9999-28527-000 AU - Schaefer, Earl S. AU - Bell, Richard Q. T1 - Parental Attitude Research Instrument JF - PsycTESTS JO - PsycTESTS Y1 - 1958/// AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No N1 - Accession Number: 9999-28527-000. Other Names: Inventory of Attitudes on Family Life and Children. Acronyms: PARI. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20150413. Instrument Type: Inventory/Questionnaire. Test Format: Each of the 115 statements on the Parental Attitude Research Instrument is rated on a 4-point scale: A = strongly agree, a = mildly agree, d = mildly disagree, D = strongly disagree.. Language: English. Constructs: Parental Attitudes; Classification: Family Relationships and Parenting (6100). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). N2 - Administration Method: Paper AB - Purpose: The purpose of the Parental Attitude Research Instrument is to reveal parental attitudes toward family life and child rearing as reported by mothers. AB - Description: The 115-item Parental Attitude Research Instrument (PARI; Schaefer & Bell, 1958) is an attitude questionnaire completed by mothers to reveal parental attitudes toward family life and child rearing. This measure was developed based on theories of parental influence upon development of children and a review of previous research on the relationship of parental attitudes to the personality adjustment of children. A set of 32 concepts were selected which were derived from previous studies (Mark, 1953; Shoben, 1949) and from a search of the literature on parent-child relationships. Attitude scales of 5-10 items which gave satisfactory reliability for research purposes were developed with an iterative technique of attitude measurement. Item and reliability analyses resulted in the final form, which consists of 23 five-item scales. All items (e.g., 'A good mother should shelter her child from life's little difficulties' and 'Strict discipline develops a fine strong character') are rated on a 4-point scale: A = strongly agree, a = mildly agree, d = mildly disagree, D = strongly disagree. In samples of samples of multiparae and primiparae, internal consistency reliability coefficients were satisfactory. Three-month test-retest reliabilities were generally good although a few scales on which there was very little variability in score had appreciably lower test-retest reliability as compared to internal consistency reliability. The studies surveyed in the review of literature could be cited as evidence supporting the concurrent validity of this general approach to the study of parent-child relationships. The content validity or the adequacy of the concepts of parental attitudes toward child-rearing can be determined by attempting to add concepts which would add new variance to measurement of this domain. Adequate evidence of the construct validity of these scales must be based upon research on various correlates of these measures. (PsycTESTS Database Record (c) 2015 APA, all rights reserved) KW - Parental Attitude Research Instrument KW - Mothers KW - Test Development KW - Internal Consistency KW - Test-Retest Reliability KW - Concurrent Validity KW - Child Rearing Attitudes KW - Family Life U5 - Parental Attitude Research Instrument (PARI) [Test Development]Development of a Parental Attitude Research Instrument. (AN: 1960-01417-001 from PsycINFO) Schaefer, Earl S.; Bell, Richard Q.; Sep, 1958. Source: Child Development. 29, Blackwell Publishing, United Kingdom; Sep, 1958; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs); Population: Human; Female; Location: US; Sample: Multiparae; Primiparae Keywords: Parental Attitude Research Instrument; Mothers; Test Development; Internal Consistency; Test-Retest Reliability; Concurrent Validity; Child Rearing Attitudes; Family Life; Subjects: Attitude Measures; Childrearing Attitudes; Family Relations; Inventories; Mothers; Parental Attitudes; Test Construction; Test Reliability; Test Validity; DO - 10.1037/t28527-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-28527-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - CHAP ID - 2006-10211-003 AN - 2006-10211-003 AU - Evarts, Edward V. ED - Rinkel, Max ED - Rinkel, Max, (Ed) T1 - Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept. T2 - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957. Y1 - 1958/// SP - 41 EP - 62 CY - New York, NY, US PB - McDowell, Obolensky N1 - Accession Number: 2006-10211-003. Partial author list: First Author & Affiliation: Evarts, Edward V.; National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Behavior; Electrophysiology; Lysergic Acid Diethylamide; Neurology; Pharmacology. Minor Descriptor: Biochemistry; Bufotenine; Cats; Experimental Psychosis; Experimentation; Monkeys; Psychiatry; Psychosis; Serotonin. Classification: Psychopharmacology (2580); Schizophrenia & Psychotic States (3213). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22. AB - Within recent years three discoveries have led to increased prominence of psychotomimetic agents as research tools in experimental psychiatry. These three discoveries were: first, the demonstration of the remarkable psychological actions and potency of d-lysergic acid diethylamide (LSD); second, the isolation and chemical identification of 5-hydroxytryptamine (5-HT) (10, 30); and third, the demonstration that LSD is a potent antagonist of 5-HT in vitro (19, 41). In this chapter neuropharmacological studies in animals on the basis of these three fundamental discoveries are summarized, and as the result of these studies speculations about a chemical basis for psychosis in humans are offered. The experiments were begun in an attempt to gain further knowledge about those behavioral and electrophysiological effects of LSD which might be relevant to an explanation of the effects of LSD on psychological processes in man. The hypothesis of Gaddum (20) and of Woolley and Shaw (41, 42) that the actions of LSD were related to its interaction with 5-HT served as a point of departure. One approach to obtaining further knowledge of the mechanism of action of LSD was to examine the effects of other substances whose actions might also be related to an interaction with 5-HT. One such obvious source is the class of structural congeners of 5-HT, and therefore a series of experiments was started with a small group of tryptamine and LSD derivatives. It was the purpose of these experiments to obtain information concerning the degree to which analogues of 5-HT might produce neuropharmacological effects which corresponded to those of the LSD. The first 5-HT congener which we studied was bufotenine, the N-dimethyl derivative of 5-HT. The investigations of the actions of bufotenine were undertaken on the basis of the theoretical considerations and as the result of Stromberg's (37) discovery that bufotenine is the principal alkaloid of cohoba (33), which the natives of Haiti used as a stimulating snuff. The possibility that bufotenine was the active agent in cohoba, and, therefore, a psychotomimetic agent, made the studies of its neuropharmacological actions of particular interest. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - chemical basis for psychosis KW - monkeys KW - neuropharmacological studies KW - cats KW - LSD KW - 5-HT KW - experimental psychiatry KW - behavior KW - bufotenine KW - electrophysiology KW - 1958 KW - Behavior KW - Electrophysiology KW - Lysergic Acid Diethylamide KW - Neurology KW - Pharmacology KW - Biochemistry KW - Bufotenine KW - Cats KW - Experimental Psychosis KW - Experimentation KW - Monkeys KW - Psychiatry KW - Psychosis KW - Serotonin KW - 1958 DO - 10.1037/11190-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-10211-015 AN - 2006-10211-015 AU - Brodie, Bernard B. AU - Bogdanski, Donald F. AU - Shore, Parkhurst A. ED - Rinkel, Max ED - Rinkel, Max, (Ed) T1 - Serotonin in Relation to Brain Function: III. The Action of Psychotropic Drugs (A Biochemical and Physiological Interpretation). T2 - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957. Y1 - 1958/// SP - 190 EP - 203 CY - New York, NY, US PB - McDowell, Obolensky N1 - Accession Number: 2006-10211-015. Partial author list: First Author & Affiliation: Brodie, Bernard B.; Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Brain; Drugs; Parasympathetic Nervous System; Pharmacology; Sympathetic Nervous System. Minor Descriptor: Biochemistry; Norepinephrine; Physiology; Serotonin; Theories. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 14. AB - The theory is presented that the autonomic, somatic and psychic functions of the body are maintained in a balanced state by two opposing systems, the trophotropic and ergotropic, and that these systems have receptor sites that are modulated by serotonin and norepinephrine, respectively. A number of drugs may be classified and their mechanism of action described according to their effects on the trophotropic or ergotropic systems. In considering the following views, it must be borne in mind that since the two subcortical brain systems are antagonistic, it should be possible to produce the same syndrome by stimulating one system or by depressing the other. Accordingly, the following possibilities present themselves: A) A drug may produce the trophotropic syndrome by activation of the trophotropic system or by depression of the ergotropic system. B) A drug may produce the ergotropic syndrome by blocking the trophotropic system (thus unmasking the ergotropic) or by directly stimulating the ergotropic system. C) A drug may affect the diencephalic integrative mechanisms by blocking monoamine oxidase. D) A drug may block the synthesis of serotonin or norepinephrine. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - subcortical brain systems KW - serotonin KW - psychic functions KW - ergotropic system KW - theory KW - autonomic functions KW - psychotrophic drug action KW - trophotropic system KW - norepinephrine KW - somatic functions KW - 1958 KW - Brain KW - Drugs KW - Parasympathetic Nervous System KW - Pharmacology KW - Sympathetic Nervous System KW - Biochemistry KW - Norepinephrine KW - Physiology KW - Serotonin KW - Theories KW - 1958 DO - 10.1037/11190-015 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-10211-019 AN - 2006-10211-019 AU - McDonald, Roger K. ED - Rinkel, Max ED - Rinkel, Max, (Ed) T1 - Experimental Studies with Fluids Obtained from Psychotic Patients: II. Ceruloplasmin and Schizophrenia. T2 - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957. Y1 - 1958/// SP - 230 EP - 237 CY - New York, NY, US PB - McDowell, Obolensky N1 - Accession Number: 2006-10211-019. Partial author list: First Author & Affiliation: McDonald, Roger K.; Section on Medicine, Laboratory of Clinical Science, National Institute of Mental Health, U. S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Ascorbic Acid; Biochemistry; Blood Proteins; Enzymes; Schizophrenia. Minor Descriptor: Blood Plasma; Physiological Correlates. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 8. AB - Early in 1957 Akerfeldt (4, 5) reported his experience with a simple blood test for mental disease. This test consists of adding an aromatic dye, N-N-dimethylparaphenylenediamine (DPP), to serum and measuring the intensity of the red color which developed over a period of six minutes. Akerfeldt noted that DPP was converted to its oxidized form, Wurster's red, more rapidly by the sera from schizophrenic patients than by the sera from normal controls. Akerfeldt concluded that the differences in the dye reaction between schizophrenic and normal control sera were due to the low ascorbic acid concentration and high ceruloplasmin concentration in schizophrenic serum. The contribution of Akerfeldt was re-emphasizing findings of serum abnormalities in schizophrenia previously reported, and devising a simple test in which the two assumed abnormalities serve as primary determinants. During the past year McDonald, Weise, Patrick and Evans have conducted investigations on chronic schizophrenic patients and control subjects, matched for age and sex. Because the plasma ascorbic acid and ceruloplasmin concentrations are primarily involved in Akerfeldt's test, these parameters were assessed concomitantly with the dye oxidation curves. The results are summarized. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - ascorbic acid concentrations KW - schizophrenic patients KW - ceruloplasmin concentrations KW - plasma KW - physiological correlates KW - 1958 KW - Ascorbic Acid KW - Biochemistry KW - Blood Proteins KW - Enzymes KW - Schizophrenia KW - Blood Plasma KW - Physiological Correlates KW - 1958 DO - 10.1037/11190-019 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-019&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-07701-001 AN - 1959-07701-001 AU - Blough, Donald S. T1 - A method for obtaining psychophysical thresholds from the pigeon. JF - Journal of the Experimental Analysis of Behavior JO - Journal of the Experimental Analysis of Behavior JA - J Exp Anal Behav Y1 - 1958/// VL - 1 SP - 31 EP - 43 CY - US PB - Journal of the Experimental Analysis of Behavior SN - 0022-5002 SN - 1938-3711 N1 - Accession Number: 1959-07701-001. PMID: 13870167 Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, Bethesda, Md. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19590401. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 13. Issue Publication Date: 1958. AB - The presentation, in detail, of a method for studying psychophysical thresholds in the pigeon. Essentially, through operant conditioning techniques, the pigeon is taught to press one key when a stimulus is perceived and a second key when it is not perceived. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PSYCHOPHYSICS KW - THRESHOLDS KW - IN PIGEON KW - STUDY METHOD KW - PIGEON KW - PSYCHOPHYSICAL THRESHOLDS KW - LEARNING & MEMORY KW - 1958 KW - No terms assigned KW - 1958 DO - 10.1901/jeab.1958.1-31 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07701-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2005-12000-007 AN - 2005-12000-007 AU - Garmezy, Norman T1 - The training program of the National Institute of Mental Health: Its implications for mental health programs. JF - American Psychologist JO - American Psychologist JA - Am Psychol Y1 - 1958/01// VL - 13 IS - 1 SP - 37 EP - 40 CY - US PB - American Psychological Association SN - 0003-066X SN - 1935-990X N1 - Accession Number: 2005-12000-007. Partial author list: First Author & Affiliation: Garmezy, Norman; National Institute of Mental Health, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Conference of Chief Psychologists in State Mental Health Programs, Aug, 1956, Chicago, IL. Conference Note: This paper was presented at the aforementioned conference. Major Descriptor: Community Mental Health; Mental Health; Mental Health Programs; Mental Health Services; Psychotherapy Training. Minor Descriptor: Funding. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. Page Count: 4. Issue Publication Date: Jan, 1958. Copyright Statement: American Psychological Association. 1958. AB - The year 1956 marked the tenth anniversary of the Training Grants Program of the National Institute of Mental Health (NIMH). From very meager beginnings in 1948 they had advanced to the very substantial position which they now occupy in fiscal year 1957. This article looks backward briefly to when the National Mental Health Act was passed with the goal of improving the mental health of our nation. It describes the objectives and growth of the NIMH mental health program, which was established to help attain this goal. The article also describes several ongoing public mental health programs that reflect NIMH training grant support and problems in program implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - Training Grants Program of the National Institute of Mental Health KW - training program KW - National Mental Health Act KW - 1958 KW - Community Mental Health KW - Mental Health KW - Mental Health Programs KW - Mental Health Services KW - Psychotherapy Training KW - Funding KW - 1958 DO - 10.1037/h0038374 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12000-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-07282-001 AN - 1959-07282-001 AU - Geisser, Seymour T1 - A note on McQuitty's index of concomitance. JF - Educational and Psychological Measurement JO - Educational and Psychological Measurement JA - Educ Psychol Meas Y1 - 1958/// VL - 18 SP - 125 EP - 128 CY - US PB - Sage Publications SN - 0013-1644 SN - 1552-3888 N1 - Accession Number: 1959-07282-001. Partial author list: First Author & Affiliation: Geisser, Seymour; National Institute of Mental Health. Release Date: 19590301. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 4. Issue Publication Date: 1958. AB - A concomittance coefficient is derived that is considered to have 2 advantages over the one proposed by McQuitty in (a) being sensitive only to the number of agreements, and (b) being capable of being related to known sampling distributions. The coefficient is stated as: C = (r + k - n)/rk, in which r = number of people marking yes to at least one of the ideas, k = number of people marking yes to A, and r = number of people marking yes to B. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - MCQUITTY KW - INDEX OF CONCOMITANCE KW - MODIFICATION PROPOSAL KW - CORRELATION KW - CONCOMITANCE COEFFICIENT KW - STATISTICS KW - 1958 KW - No terms assigned KW - 1958 DO - 10.1177/001316445801800112 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07282-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-07982-001 AN - 1959-07982-001 AU - Bayley, Nancy T1 - Value and limitations of infant testing. JF - Children JO - Children JA - Children Y1 - 1958/// VL - 5 SP - 129 EP - 133 CY - US PB - United States Children’s Bureau SN - 0009-4064 N1 - Accession Number: 1959-07982-001. Other Journal Title: Children Today. Partial author list: First Author & Affiliation: Bayley, Nancy; National Institute of Mental Health. Release Date: 19590401. Correction Date: 20130617. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 5. Issue Publication Date: 1958. AB - After reviewing briefly the history of the psychological testing of infants, the author discusses growth studies of normal infants, the Berkeley growth studies, hereditary determinants of mental development, the effects of environment on intellectual development, and the uses of tests both for persons concerned and persons tested. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - INFANCY KW - TESTING OF KW - CHILDHOOD & ADOLESCENCE KW - 1958 KW - No terms assigned KW - 1958 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07982-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 1959-07482-001 AN - 1959-07482-001 AU - Blough, Donald S. T1 - Rise in the pigeon's threshold with a red test stimulus during dark adaptation. JF - Journal of the Optical Society of America JO - Journal of the Optical Society of America JA - J Opt Soc Am Y1 - 1958/// VL - 48 SP - 274 EP - 274 CY - US PB - Optical Society of America SN - 0030-3941 N1 - Accession Number: 1959-07482-001. PMID: 13526049 Other Journal Title: Journal of the Optical Society of America, A, Optics, Image & Science; Journal of the Optical Society of America, A, Optics, Image Science & Vision. Partial author list: First Author & Affiliation: Blough, Donald S.; National Institute of Mental Health, Bethesda, Md. Release Date: 19590401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 1. Issue Publication Date: 1958. AB - Following pre-exposure to white light the pigeon's threshold to a 700 mμ falls slightly at first, then rises 0.1-0.2 log units and falls once more. The rise and fall occur later with increasing duration of pre-exposure. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - PIGEON KW - DARK ADAPTATION IN KW - DARK ADAPTATION KW - WHITE LIGHT PRE-EXPOSURE & KW - VISION KW - 1958 KW - No terms assigned KW - 1958 DO - 10.1364/JOSA.48.000274 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-07482-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2005-13096-001 AN - 2005-13096-001 AU - Rosvold, H. Enger AU - Mishkin, Mortimer AU - Szwarcbart, Maria K. T1 - Effects of subcortical lesions in monkeys on visual-discrimination and single-alternation performance. JF - Journal of Comparative and Physiological Psychology JO - Journal of Comparative and Physiological Psychology JA - J Comp Physiol Psychol Y1 - 1958/08// VL - 51 IS - 4 SP - 437 EP - 444 CY - US PB - American Psychological Association SN - 0021-9940 N1 - Accession Number: 2005-13096-001. PMID: 13575600 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Rosvold, H. Enger; National Institute of Mental Health, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Caudate Nucleus; Delayed Alternation; Superior Colliculus; Visual Discrimination. Minor Descriptor: Animal Learning; Monkeys. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 1958. Copyright Statement: American Psychological Association. 1958. AB - Tested whether or not monkeys with lesions in the superior colliculus would show impairment in learning a visual-discrimination task, while animals with lesions in the head of the caudate nucleus would show impairment in learning a delayed-response-type task. Ss were 29 monkeys. Each operated group served as a control for the other group. There was, in addition, an unoperated control group. Visual-discrimination learning was not impaired in any of the operated animals. The learning scores of all the operated animals, including those with extensive lesions in the superior colliculus, fell within the range of scores obtained by the group of unoperated controls. In view of the severe visual impairment reported in cats with collicular lesions, no explanation, other than a recourse to species differences, can be offered to account for the lack of effect following similar damage in monkeys. While it is possible that the damage was not extensive enough to produce impairment, it should be noted that relatively less extensive destruction in the caudate nucleus produced marked alternation deficit. The negative visual-discrimination results leave open the two related questions of how the inferotemporal cortex is related to visual-discrimination functions, and what function is served in monkey by the connections which have been described between the temporal neocortex and the superior colliculus. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - brain lesions KW - superior colliculus KW - caudate nucleus KW - visual discrimination task KW - delayed response task KW - single-alternation performance KW - monkeys KW - 1958 KW - Caudate Nucleus KW - Delayed Alternation KW - Superior Colliculus KW - Visual Discrimination KW - Animal Learning KW - Monkeys KW - 1958 DO - 10.1037/h0038337 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13096-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Rosenberg, Herbert H. T1 - The Administrative State. JO - Administrative Science Quarterly JF - Administrative Science Quarterly Y1 - 1958/09// VL - 3 IS - 2 M3 - Book Review SP - 265 EP - 267 PB - Administrative Science Quarterly SN - 00018392 AB - The article reviews the book "The Administrative State," by Fritz Morstein Marx. KW - BUREAUCRACY KW - NONFICTION KW - MARX, Fritz Morstein KW - ADMINISTRATIVE State, The (Book) N1 - Accession Number: 6439375; Rosenberg, Herbert H. 1; Affiliations: 1: Chief, Research Resources Section, Office of Research Planning, National Institutes of Health, Bethesda, Maryland.; Issue Info: Sep58, Vol. 3 Issue 2, p265; Thesaurus Term: BUREAUCRACY; Subject Term: NONFICTION; Reviews & Products: ADMINISTRATIVE State, The (Book); People: MARX, Fritz Morstein; Number of Pages: 3p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=6439375&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Herbst, William P. T1 - Management of inoperable cancer of the prostate. JO - Geriatrics JF - Geriatrics Y1 - 1958/09// VL - 13 IS - 9 M3 - Article SP - 574 EP - 575 SN - 0016867X N1 - Accession Number: 17821682; Herbst, William P. 1,2; Source Information: Sep1958, Vol. 13 Issue 9, p574; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 978 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17821682&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Perlin, Seymour T1 - Psychiatric screening in a home for the aged. JO - Geriatrics JF - Geriatrics Y1 - 1958/11// VL - 13 IS - 11 M3 - Article SP - 747 EP - 751 SN - 0016867X N1 - Accession Number: 17810310; Perlin, Seymour 1; Source Information: Nov1958, Vol. 13 Issue 11, p747; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 2403 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17810310&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2006-05960-001 AN - 2006-05960-001 AU - Bobbitt, Joseph M. T1 - Psychology on Display. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1958/11// VL - 3 IS - 11 SP - 321 EP - 323 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05960-001. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Health Promotion; Mental Health; Psychologists; Social Sciences. Minor Descriptor: History of Psychology; Social Psychology. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Reviewed Item: Havemann, Ernest. The Age of Psychology=New York: Simon and Schuster, 19S7. Pp. ix + 115. $3.50 (cloth); $1.00 (paper); 1957. Page Count: 3. Issue Publication Date: Nov, 1958. AB - Reviews the book, The Age of Psychology by Ernest Havemann (see record [rid]1959-00015-000[/rid]). The author appears unaware of the fact that the prevention of illness and promotion of mental health are becoming today reachable objectives and that the task involved goes far beyond the clinical domain, encompassing social psychology and the other social sciences in their most sophisticated possibilities. None of the research on rehabilitation of mental patients, problems of the aging population, the mental-health effects of school experience, child development, and other hopeful approaches to the improvement of the mental health of our people is covered in this book. Perhaps the big disappointment, therefore, lies in the failure of the author to show that psychology and its related disciplines are now emerging as areas of study basically related to the everyday problems of everyday people, whether they be clinically ill or not. The book will be unsatisfying to many psychologists. Possibly the average man will learn something from it, but he will not learn much about psychology as a serious scientific discipline. Nor will he gain perspective in the understanding of behavioral science, nor learn much about what is happening in psychology today or during the last five or ten years. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - motivation research KW - social psychology KW - social sciences KW - mental health promotion KW - age of psychology KW - 1958 KW - Clinical Psychology KW - Health Promotion KW - Mental Health KW - Psychologists KW - Social Sciences KW - History of Psychology KW - Social Psychology KW - 1958 U2 - Havemann, Ernest. (1957); The Age of Psychology; New York: Simon and Schuster, 19S7. Pp. ix + 115. $3.50 (cloth); $1.00 (paper) DO - 10.1037/005712 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05960-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - AU - Birren, James E.1 T1 - Aging and Psychological Adjustment. JO - Review of Educational Research JF - Review of Educational Research J1 - Review of Educational Research PY - 1958/12// Y1 - 1958/12// VL - 28 IS - 5 CP - 5 M3 - Article SP - 475 EP - 490 SN - 00346543 AB - This articles reviews the research on the increase of scientific and professional interest in older persons which involves aging and psychological adjustment. Adult adjustment, despite the difference in content, might involve the same psychological mechanisms as in childhood. Developmental model for aging which includes the variables pertinent to adjustment was described by the author. Consequences of early childhood experiences and educational practices will increasingly be examined for their significance not only to the early years but also to the adjustment of the mature and aging adult. KW - Adjustment (Psychology) in old age KW - Geropsychology KW - Developmental biology KW - Adjustment (Psychology) KW - Adaptability (Psychology) KW - Aging KW - Growth KW - Human growth N1 - Accession Number: 18811047; Authors: Birren, James E. 1; Affiliations: 1: Section on Aging, National Institute of Mental Health, U. S. Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland; Subject: Adjustment (Psychology) in old age; Subject: Geropsychology; Subject: Developmental biology; Subject: Adjustment (Psychology); Subject: Adaptability (Psychology); Subject: Aging; Subject: Growth; Subject: Human growth; Number of Pages: 16p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=18811047&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - JOUR AU - Hunt, G. Halsey T1 - Implications of aging as predicted by population changes. JO - Geriatrics JF - Geriatrics Y1 - 1959/01// VL - 14 IS - 1 M3 - Article SP - 1 EP - 7 SN - 0016867X N1 - Accession Number: 20877890; Hunt, G. Halsey 1,2; Source Information: Jan1959, Vol. 14 Issue 1, p1; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3943 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20877890&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - CHAP ID - 2007-00124-002 AN - 2007-00124-002 AU - Bobbitt, Joseph M. ED - Roe, Ann ED - Gustad, John W. ED - Moore, Bruce V. ED - Ross, Sherman ED - Skodak, Marie ED - Roe, Ann, (Ed) ED - Gustad, John W., (Ed) ED - Moore, Bruce V., (Ed) ED - Ross, Sherman, (Ed) ED - Skodak, Marie, (Ed) T1 - Opening Remarks. T2 - Graduate education in psychology: Report of the Conference on Graduate Education in Psychology. Y1 - 1959/// SP - 19 EP - 23 CY - Washington, DC, US PB - American Psychological Association N1 - Accession Number: 2007-00124-002. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20070205. Correction Date: 20151221. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Conference on Graduate Education in Psychology, Nov-Dec, 1958, Miami Beach, FL, US. Conference Note: Reported at the aforementioned conference sponsored by the Education and Training Board of the American Psychological Association. Major Descriptor: Graduate Psychology Education. Minor Descriptor: Sciences. Classification: Professional Education & Training (3410). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - This chapter presents the opening remarks given at the 1958 Conference on Graduate Education in Psychology. It states that the pressing reason for this conference is the need to resolve the difficulties growing out of the dual development as both a science and a profession. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - graduate psychology education KW - science KW - profession KW - 1959 KW - Graduate Psychology Education KW - Sciences KW - 1959 DO - 10.1037/11398-002 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00124-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-004 AN - 2006-20945-004 AU - Evarts, Edward V. AU - Butler, Robert N. ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - A Review of the Effects of Chlorpromazine and Reserpine in Patients with Mental Disorders. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 64 EP - 82 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-004. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Chlorpromazine; Drug Therapy; Drugs; Mental Disorders; Psychopharmacology. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 19. AB - The purpose of this review is to clarify the status of chlorpromazine and reserpine as pharmacotherapeutic agents in mental illness. In order to evaluate the therapeutic efficacy of a given pharmacological agent, one must answer certain questions about the action of the agent. Three of these questions are: What are the effects of the drug? Are the effects beneficial? How do the effects compare with those of other therapies? In this review, an outline suggested by these three questions will be followed. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - pharmacotherapeutic agents KW - chlorpromazine KW - reserpine KW - mental disorders KW - drug effects KW - 1959 KW - Chlorpromazine KW - Drug Therapy KW - Drugs KW - Mental Disorders KW - Psychopharmacology KW - 1959 DO - 10.1037/11259-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-006 AN - 2006-20945-006 AU - Cole, Jonathan O. ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - The Evaluation of the Effectiveness of Treatment in Psychiatry. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 92 EP - 107 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-006. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Evaluation; Psychiatric Patients; Psychiatry; Treatment Effectiveness Evaluation. Minor Descriptor: Experiment Controls; Followup Studies. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Inpatient (50). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 16. AB - In considering the various steps involved in the organization of research to evaluate the effects of a psychiatric treatment, it seemed best to break the process down into (a) the control problem, (b) the evaluation of the patient, and (c) the follow-up problem. No attempt will be made to consider in detail the specific evaluation of the effects of any particular treatment; only relatively nonspecific aspects of the treatment situation will be discussed. Since a good deal of the work evaluating the ataraxic drugs has been done upon hospitalized psychiatric patients, most of the discussion will be focused toward that group. The problems involved in evaluating the effects of therapy on outpatients would seem to be similar, only more complex. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - treatment effectiveness evaluation KW - psychiatry KW - control problem KW - patient evaluation KW - follow-up problem KW - 1959 KW - Evaluation KW - Psychiatric Patients KW - Psychiatry KW - Treatment Effectiveness Evaluation KW - Experiment Controls KW - Followup Studies KW - 1959 DO - 10.1037/11259-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-007 AN - 2006-20945-007 AU - Kramer, Morton ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - Public Health and Social Problems in the Use of Tranquilizing Drugs. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 108 EP - 142 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-007. Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Drug Therapy; Social Issues; Tranquilizing Drugs. Minor Descriptor: Public Health. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 35. AB - This reprinted chapter originally appeared in (Public Health Monograph, 1956, No. 41). (The following abstract of the original article appeared in record [rid]1957-08051-001[/rid].) The advent of tranquilizing drugs is considered in relation to possible consequences for the psychiatric profession, other branches of medical practice, the epidemiologist, the social scientist, and the bio-statistician. Gaps in present knowledge concerning the extent to which tranquilizing drugs are in use, their immediate and long range effects, and their possible effects on mental hospital populations are pointed out. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - tranquilizing drugs KW - public health KW - social problems KW - 1959 KW - Drug Therapy KW - Social Issues KW - Tranquilizing Drugs KW - Public Health KW - 1959 DO - 10.1037/11259-007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-015 AN - 2006-20945-015 AU - Rosvold, H. Enger ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - Evaluation of the Effects of Pharmacological Agents on Social Behavior. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 245 EP - 254 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-015. Partial author list: First Author & Affiliation: Rosvold, H. Enger; Section on Animal Behavior, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Drugs; Evaluation; Mental Disorders; Pharmacology; Social Behavior. Minor Descriptor: Animal Social Behavior; Drug Therapy; Screening; Treatment Effectiveness Evaluation. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 10. AB - Mental illness is manifest for the most part in the inappropriate manner in which the individual interacts with other people. He may be too aggressive, too hostile, too fearful, too unresponsive, too amorous for his fellows to bear; or perhaps he may perceive his role in the group to be something other than the rest of his group is willing to concede. Unhappy over his unsatisfactory interpersonal relationships, he comes to treatment; or troublesome to society, he is required to be treated. Whichever the reason, it is hoped that the treatment will result in the individual's being more at ease with his fellows and behaving more like them. It is thus pertinent to evaluate the effectiveness of pharmacotherapy in changing an individual's social behavior. Either human or other animal groups may be used. In the discussion that follows the term social behavior will refer to any behavior that an animal displays in relation to one or more other individuals that does not appear or cannot be observed when an animal is alone. It is an animal's responses to the demands made of him by other individuals, and those responses are frequently, though not always, different from his behavior when alone. It is the purpose of this paper to describe some techniques for studying such behavior and to suggest how they might be used in evaluating the effects of pharmacological agents. These methods may be applied to four different aspects of an evaluation program. These may be characterized as (a) description, (b) screening, (c) localization, and (d) extension. A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - social behavior KW - mental illness KW - evaluation KW - pharmacological agents KW - 1959 KW - Drugs KW - Evaluation KW - Mental Disorders KW - Pharmacology KW - Social Behavior KW - Animal Social Behavior KW - Drug Therapy KW - Screening KW - Treatment Effectiveness Evaluation KW - 1959 DO - 10.1037/11259-015 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-018 AN - 2006-20945-018 AU - Evarts, Edward V. ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - A Discussion of the Relevance of Effects of Drugs on Animal Behavior to the Possible Effects of Drugs on Psychopathological Processes in Man. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 284 EP - 306 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-018. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Animal Ethology; Drugs; Psychopathology; Psychopharmacology. Minor Descriptor: Animals; Drug Therapy; Mental Disorders; Schizophrenia; Screening Tests. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23. AB - Since the introduction of chlorpromazine, reserpine, and numerous other 'tranquilizing agents,' there has been a great increase in the quantity of research devoted to the discovery of additional, and perhaps superior, 'psychotherapeutic' drugs. It is to be hoped that expansion of research in this area will be productive of more than new and better tranquilizing agents. The limitations of therapeutic agents with psychological effects similar to those of chlorpromazine and reserpine have become increasingly clear: on the basis of evidence available to date, such drugs would appear to make disturbed patients cooperative but to leave them none the less psychotic. The widespread use of reserpine and chlorpromazine in mental hospitals has certainly resulted in a beneficial change in the atmosphere of formerly disturbed psychiatric wards; the fact remains that, in spite of these beneficial changes, patients have in large measure remained hospitalized. In short, the tranquilizing drugs appear to have transformed disturbed psychotic patients into undisturbed psychotic patients. It is the purpose of this paper to examine certain of the problems which may arise in connection with attempts to develop drugs whose therapeutic effects may exceed mere 'tranquilization'; that is, drugs which may actually alter certain of the primary psychopathological disturbances of the psychotic patient. As will be made clear later on, these primary psychopathological disorders are not seen as including motor hyperactivity, assaultiveness, etc., which are viewed as secondary symptoms of certain more basic psychological deficits. There are many approaches which might be employed in attempts to discover drugs which do more than tranquilize. In the present paper, a relatively restricted segment of this potentially vast area will be dealt with. In particular, this paper will discuss the degree to which the effects of drugs on animal behavior may be used in the selection of agents which may alter specific aspects of the primary psychopathological disorders of schizophrenia. The use of animal screening tests in the selection of drugs has been singled out for discussion because, in the opinion of this author, it represents the most difficult, and possibly the limiting step in the process by which new drugs are brought to therapeutic trial. The discussion will deal with the selection of drugs for therapeutic trial in schizophrenic disorders, rather than in mental disorders in general. The clinical field has been restricted in order to allow an attempt to relate the results of screening tests to possible effects of drugs on specific forms of psychological disorder; such an effort would be considerably more difficult if the range of clinical disorders under discussion were of unlimited scope. A discussion about this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychopathological processes KW - schizophrenic disorders KW - drug effects KW - animal behavior KW - animal screening tests KW - 1959 KW - Animal Ethology KW - Drugs KW - Psychopathology KW - Psychopharmacology KW - Animals KW - Drug Therapy KW - Mental Disorders KW - Schizophrenia KW - Screening Tests KW - 1959 DO - 10.1037/11259-018 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-018&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-023 AN - 2006-20945-023 AU - Kramer, Morton AU - Greenhouse, Samuel W. ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - Determination of Sample Size and Selection of Cases. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 356 EP - 371 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-023. Partial author list: First Author & Affiliation: Kramer, Morton; Biometrics Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Sample Size; Sampling (Experimental); Tranquilizing Drugs. Classification: Research Methods & Experimental Design (2260); Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. AB - This paper will consider some of the problems involved in determining the size of both experimental and control groups (i.e., the number of cases needed) in experiments designed to detect effects of tranquilizing drugs. An essential part of the planning stage of an experiment is to determine the size of the control and experimental groups to be studied. The size of these groups can be established adequately only by taking account of the following considerations: (a) an explicit statement of the question(s) to be investigated; (b) the minimum difference the investigator desires to detect as significant; and (c) the certainty with which the investigator desires to avoid each of two possible errors that can be made in accepting or rejecting the hypotheses tested. Although the questions that this conference wants to answer about the effect of the transquilizers have as yet not been specified, let us assume that the problem under investigation is to determine the effect of a tranquilizer on the improvement rate in male schizophrenic patients hospitalized in state mental hospitals. We will assume further that we are in that Utopian stage where diagnostic methods and methods of determining improvement are sufficiently well standardized from hospital to hospital within the same state system as well as between state systems so that results may be compared within or between hospitals without introducing uncontrolled variations into the experiment from these two sources (i.e., diagnosis and measurement of improvement). A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - sample size KW - case selection KW - tranquilizing drugs KW - drug effects KW - 1959 KW - Sample Size KW - Sampling (Experimental) KW - Tranquilizing Drugs KW - 1959 DO - 10.1037/11259-023 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-023&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2006-20945-028 AN - 2006-20945-028 AU - Rosenthal, David ED - Cole, Jonathan O. ED - Gerard, Ralph W. ED - Cole, Jonathan O., (Ed) ED - Gerard, Ralph W., (Ed) T1 - Drug Research Design in Psychiatric Outpatient Setting. T2 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// SP - 434 EP - 446 CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-028. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Experimental Design; Outpatients; Psychiatric Patients; Psychopharmacology; Research Setting. Classification: Research Methods & Experimental Design (2260); Clinical Psychopharmacology (3340). Population: Human (10); Outpatient (60). Intended Audience: Psychology: Professional & Research (PS). Page Count: 13. AB - I shall discuss what I know best from actual experience, namely the 'own-control' type of design. I shall describe some major steps in own-control procedures and discuss some problems encountered at each step. Some points will be germane to all kinds of drug research with psychiatric patients, but in the main I shall concentrate on special problems posed by the outpatient setting. A drug is most likely to be tested at either of two early stages in its clinical history: 1. An exploratory stage: the drug may have been found to have some special effects with experimental animals or nonpsychiatric clinical groups, and we wish to see how it affects various types of psychiatric patients. 2. A testing stage: the drug has been explored clinically and has been reported to be effective for certain diagnostic groups. If we are at the exploratory stage, the patient sample will be of heterogeneous composition. At the second stage we will be more likely to test the drug for one diagnostic group at a time. I shall concern myself with the exploratory stage because drugs are almost always pretested on inpatients where routine procedures are more closely observed and controlled, and because the applicability to psychiatric outpatients of preliminary reports resulting from such early studies is often doubtful. Moreover, such a wide variety of clinical groups are found in outpatient clinics that most are not yet represented in preliminary studies. They include immaturity problems, diverse neuroses, ambulatory schizophrenics, personality disorders, etc. (as well as mental defectives, organic syndromes, antisocial psychopaths, and some quite disorganized schizophrenics whom we shall not consider). Our task is to see whether any of these kinds of outpatients may be helped by a drug, and the sample is denned only in terms of the kinds of patients excluded. That has an important bearing on the type of research design employed, because it renders inadequate the usual procedure which aims at measuring drug-induced changes in the sample group as a whole. A discussion on this paper is presented at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric patients KW - outpatient setting KW - drug research design KW - 1959 KW - Experimental Design KW - Outpatients KW - Psychiatric Patients KW - Psychopharmacology KW - Research Setting KW - 1959 DO - 10.1037/11259-028 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-028&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39118-001 AN - 2013-39118-001 AU - Redl, Fritz T1 - The life space interview workshop, 1957: Eveoleen N. Rexford, M.D., chairman: 1. Strategy and techniques of the life space interview. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/01// VL - 29 IS - 1 SP - 1 EP - 18 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39118-001. PMID: 13627104 Partial author list: First Author & Affiliation: Redl, Fritz; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1958. Conference Note: Which was presented at the presented at the aforementioned conference. Major Descriptor: Emotional States; Orthopsychiatry; Psychotherapeutic Transference; Scientific Communication. Minor Descriptor: Interviews. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Page Count: 18. Issue Publication Date: Jan, 1959. AB - This article provides an overview of the 1957 Life Space Interview Workshop of the American Orthopsychiatric Association. The Workshop focused on the strategy and techniques of the life space interview. The peculiar ritual and the behavioral prescriptions to which the patient is bound, as well as the variety of technical tools with which the therapist arms himself, make sense only when viewed as steps to the following goals: To isolate the patient enough from the pressures of adjustment he finds ; in his daily life, so as to create purposely an atmosphere which resembles, more nearly the conditions under which the roots for his neurosis developed, to get the patient to re-establish around the person of the therapist the emotional relationships toward focal people in his life which were experienced by him at that time and Through skillful manipulation of these emotional relationships-especially those of transference-and through skillful reaction to the patient's fantasy productions and behaviors, to bring about the following phenomena: (a) to enable the patient to bring unconscious material into open manifestation- and that applies not only to the id but also to unconscious ego and superego elements; (b) to help the ego recognize and handle previous experiences as well as reorganize its own techniques so that pathological symptom formation or character distortion is not any longer necessary; and (c) to give some aid to the ego in reorienting the healthier personality thus emerging, to the actual present-day tasks of life adjustment, so that dependence on therapy can safely cease. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - Life Space Interview Workshop KW - American Orthopsychiatric Association KW - scientific communication KW - emotional relationships KW - transference KW - 1959 KW - Emotional States KW - Orthopsychiatry KW - Psychotherapeutic Transference KW - Scientific Communication KW - Interviews KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00163.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39118-002 AN - 2013-39118-002 AU - Dittmann, Allen T. AU - Kitchener, Howard L. T1 - The life space interview workshop, 1957: 2. Life space interviewing and individual play therapy: A comparison of techniques. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/01// VL - 29 IS - 1 SP - 19 EP - 26 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39118-002. PMID: 13627105 Partial author list: First Author & Affiliation: Dittmann, Allen T.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Individual Psychotherapy; Orthopsychiatry; Play Therapy; Scientific Communication. Minor Descriptor: Interviews. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 1959. AB - This article presents an overview of the 1957 Life Space Interview Workshop conducted by the American Orthopsychiatric Association. The focus of the Workshop was on the comparison of techniques of life space interviewing and individual play therapy. In psychotherapy the goal for any interview is to provide an opportunity for the exploration of early conflicts of which the present symptoms are derivatives. In life space interviews the goals are action goals in keeping with the issue which initiated the interview. Where the child refuses to participate or has been removed from activity the goal is always action; although it may not be possible to get him back into the activity today, still the goal is to settle whatever is holding him back and return him to the activity as soon as possible. Where the interview is initiated by the child, the goal is to get the question answered as soon as possible or to refer the child to someone from whom he can get an answer. In addition to specific goals, there are of course in every life space interview the over-all treatment goals of the residential program as a whole. The next main basis for comparison is the role structure of the interview. The psychotherapist's role is relatively unmoved by the day-today activities of the ward, and while therapists don't go out of their way to avoid meeting the children in the halls, there isn't much contact outside the interviews. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - Life Space Interview Workshop KW - American Orthopsychiatric Association KW - individual play therapy KW - psychotherapy KW - scientific communication KW - 1959 KW - Individual Psychotherapy KW - Orthopsychiatry KW - Play Therapy KW - Scientific Communication KW - Interviews KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00164.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39118-004 AN - 2013-39118-004 AU - Shakow, David T1 - Research in child development: A case illustration of the psychologist's dilemma. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/01// VL - 29 IS - 1 SP - 45 EP - 59 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39118-004. PMID: 13627107 Partial author list: First Author & Affiliation: Shakow, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Professional Ethics; Professional Standards; Psychologists. Minor Descriptor: Childhood Development; Observers. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 15. Issue Publication Date: Jan, 1959. AB - This article presents a case illustration of the psychologist's dilemma. The dilemma stated simply is: How can one study human psychological phenomena scientifically with a minimum of distortion and ethicall-with a minimum of inevitable trespass? In fact psychoanalysts are perhaps faced with this dilemma above all others in the psychological field. The problem is so full of affect that there is danger of becoming too aware of the dilemma to the point of being anxiety-ridden by it, which must of course equally be guarded against. Part of the dilemma is how one can study human psychological phenomena scientifically with a minimum of distortion. It will be recognized that the 'distortion' that results is in a way an instance of what James called 'the psychologist's fallacy'-the error of method and interpretation in which the psychologist confuses his own knowledge about the process with what the subject directly experiences in the process. This fallacy is a peculiar hazard of the psychologist-observer when compared with the observer in the physical and biological sciences, although the hazard exists as well in nonhuman psychological fields where one is dealing with descriptions of animal behavior. The author argued for the importance of child development research to be undertaken by a guidance center-most desirably an institution with the status and standards of the Judge Baker Guidance Center. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - child development KW - psychologists KW - ethical dilemma KW - observers KW - professional standards KW - 1959 KW - Professional Ethics KW - Professional Standards KW - Psychologists KW - Childhood Development KW - Observers KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00166.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39118-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CONF ID - 2006-20945-000 AN - 2006-20945-000 AU - Cole, Jonathan O. AU - Gerard, Ralph W. ED - Cole, Jonathan O. ED - Gerard, Ralph W. T1 - Psychopharmacology: Problems in evaluation. Y1 - 1959/// CY - Washington, DC, US PB - National Academy of Sciences N1 - Accession Number: 2006-20945-000. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Classic Book; Conference Proceedings. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Illness, Sep, 1956, Washington, DC, US. Conference Note: Proceedings of a sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Evaluation; Psychopharmacology. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 662. AB - The organization of this volume has followed the various stages through which the preparation for the Conference on The Evaluation of Pharmacotherapy in Mental Illness and the actual conference went. A seventh paper, by Dr. Jack R. Ewalt, was presented at the dinner given on Friday, 21 September 1956. The general character resembles that of the introductory papers and it was therefore included with them. The first section of this volume, therefore, consists of the seven working papers, two of which were brought up to date just before the conference in September 1956, together with Dr. Gerard's summary. At the January planning meeting it was decided that five committees should be formed, composed for the most part of those participating in the planning meeting. These committees were to include the Committee on Preliminary Screening of Drugs, under the chairmanship of Dr. Louis Goodman, which was to review thoroughly our knowledge of the basic mechanisms of action of these psychoactive compounds, and more particularly the adequacy of available methods for the selection and the animal and early human screening of compounds of this general sort. The next three committees were organized as a group in order that the field of clinical drug evaluation, which was to be the primary emphasis of the conference, should receive the most thorough possible scrutiny. The general clinical area was divided into three sections. The first section, that dealing with the problems attached to the selection of patient groups for study and the problem of adequate scientific controls in clinical researches, was assigned to the Committee on Patient Selection and Controls under the chairmanship of Dr. John Clausen. The second clinical area encompassed the influence of the environment in which the drug studies were done and the problems attached to drug administration itself. This area was gradually expanded to include the more general aspects of test design in clinical drug evaluation and was assigned to the Committee on Test Conditions, under the chairmanship of Dr. Alfred Bay. The third clinical area was that of evaluation, and the third committee, the Committee on Evaluation, was to concern itself intensively with the problems of evaluation and the more detailed consideration of some of the available techniques for the measurement of change in psychiatric patients. Dr. Milton Greenblatt chaired the Committee on Evaluation and also served as 'superchairman' and coordinator of the three clinical committees. The fifth committee was called the Committee on Planning and Coordination and was to serve both as an executive committee for the conference and to consider, in broader terms, the implications of the conference. Its major attention was to be devoted to the preparation of plans for the implementation of policy recommendations and research ideas which would emerge from the conference itself. The organization of the sections devoted to the work of the several committees is not uniform, but has varied with the nature of the committee's activities. The edited discussions have been inserted, wherever they are most appropriate, either following the article to which they are pertinent or in a separate section devoted to the general work of the committee. The summaries prepared by the various committees and presented to the main conference, together with the discussion from the floor following the presentation of these summaries, have been included as a separate section at the end of the volume, and are followed by Dr. Kety's final, over-all analysis of the work of the conference and the consolidated recommendations of the various working groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychopharmacology KW - evaluation KW - 1959 KW - Evaluation KW - Psychopharmacology KW - 1959 U1 - Sponsor: Department of Health, Education, and Welfare, United States Public Health Service, National Institutes of Health; National Institute of Mental Health, US. Grant: 3M-9104. Recipients: No recipient indicated DO - 10.1037/11259-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Rosvold, H.Enger T1 - PHYSIOLOGICAL PSYCHOLOGY. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1959/02// VL - 10 IS - 1 M3 - Article SP - 415 EP - 454 PB - Annual Reviews Inc. SN - 00664308 AB - Presents information on studies related to the manipulation of brain. Organisation of the brain to serve behavior. Deterioration of the problem solving ability of adult animals; Achievements in the field of conditioned cerebral electrical responses; Reassessment of classical studies delineating neural components of conditioning. KW - PROBLEM solving KW - RESEARCH KW - BRAIN KW - HUMAN behavior KW - ANIMALS N1 - Accession Number: 11290181; Rosvold, H.Enger 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health Bethesda, Maryland.; Issue Info: 1959, Vol. 10 Issue 1, p415; Thesaurus Term: PROBLEM solving; Thesaurus Term: RESEARCH; Subject Term: BRAIN; Subject Term: HUMAN behavior; Subject Term: ANIMALS; Number of Pages: 40p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11290181&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - GEN AU - Jungk, Robert AU - Wilson, Robert R. AU - Fine, Jacob AU - Rosenthal, Sanford M. T1 - LETTERS. JO - Scientific American JF - Scientific American Y1 - 1959/03// VL - 200 IS - 3 M3 - Letter SP - 11 EP - 16 SN - 00368733 AB - Two letters to the editor is presented in response to previous articles including a review by Robert R. Wilson on the book "Brighter Than a Thousand Suns" and "Wound Shock," by Sanford Rosenthal in the December 1958 issue. KW - Letters to the editor KW - Wilson, Robert R. KW - Rosenthal, Sanford KW - Brighter Than a Thousand Suns: A Personal History of the Atomic Scientists (Book) N1 - Accession Number: 19788929; Jungk, Robert; Wilson, Robert R. 1; Fine, Jacob 2; Rosenthal, Sanford M. 3; Affiliations: 1: Cornell University, Ithaca, N.Y.; 2: Harvard Medical School, Boston, Mass.; 3: National Institutes of Health, Bethesda, Md.; Issue Info: Mar1959, Vol. 200 Issue 3, p11; Subject Term: Letters to the editor; Reviews & Products: Brighter Than a Thousand Suns: A Personal History of the Atomic Scientists (Book); People: Wilson, Robert R.; People: Rosenthal, Sanford; Number of Pages: 4p; Document Type: Letter UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19788929&site=ehost-live&scope=site DP - EBSCOhost DB - eih ER - TY - JOUR ID - 2013-39119-002 AN - 2013-39119-002 AU - Goodrich, D. Wells T1 - Observational research with emotionally disturbed children: Session I: 2. The choice of situation for observational studies of children. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/04// VL - 29 IS - 2 SP - 227 EP - 234 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39119-002. PMID: 13661298 Partial author list: First Author & Affiliation: Goodrich, D. Wells; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Design; Observation Methods; Popular Culture; Regional Differences. Minor Descriptor: Choice Behavior; Emotional Disturbances. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 8. Issue Publication Date: Apr, 1959. AB - In this article author highlights the choice of situation for observational studies of children. In planning any observational study of children's behavior, one question which arises inevitably is where to study the children. A wide spectrum of clinical and scientific issues may become relevant to deciding the location for research observations. The problem of 'choosing a situation' can be considered in reference to the general life context of a child and in reference to the in any specific geographical locations and group situations within any life context. any observational study of children's behavior, one question which arises inevitably is where to study the children. The attempt to differentiate between situational determinants of behavior and those which stem from idiosyncratic aspects of personality has been urged by means of controlled sampling of the subjects and of situations. The laboratory is particularly adapted to studying stress or to testing a few specific hypotheses about personality functioning. The residential institution provides an opportunity to observe the total range of the child's ego functioning. It is a particularly useful place in which to study children's ego strengths and the interaction between social settings and personality. The psychotherapy situation is a useful place to observe the uncovering of specific pathological fantasies and defensive operations and to observe basic change processes occurring in the ego. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - observational studies KW - choice of situation KW - child behavior KW - situational determinants KW - geographical locations KW - research settings KW - 1959 KW - Experimental Design KW - Observation Methods KW - Popular Culture KW - Regional Differences KW - Choice Behavior KW - Emotional Disturbances KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00186.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39119-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39119-003 AN - 2013-39119-003 AU - Raush, Harold L. T1 - Observational research with emotionally disturbed children: Session I: 3. On the locus of behavior–observations in multiple settings within residential treatment. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/04// VL - 29 IS - 2 SP - 235 EP - 242 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39119-003. PMID: 13661299 Partial author list: First Author & Affiliation: Raush, Harold L.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Observation Methods; Residential Care Institutions; Treatment. Minor Descriptor: Emotional Disturbances; Socialization. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 8. Issue Publication Date: Apr, 1959. AB - In this paper author highlights for the most part about some situational components which enter into behavior. He further highlights about the neglect of situational aspects in personality research. For the chief proposition of the paper is that they meet behavior at the juncture of these two classes of variables, and it is the study of this juncture that he wish mainly to emphasize. There have been many comments on the role of food and its use in the socialization of disturbed children. The relevance of the eating situation was confirmed when they found that such situations-breakfast other mealtimes, the snack period before going to bed-produced considerably fewer hostile interactions than did nonfood settings-structured games, unstructured group activities, and arts and crafts sessions. The influence of situational factors is not limited to their general over-all effects. he has implied that the setting components operated somewhat differently in the two time periods. Both the situational factors and the individual personality components that go into creating behavior have been defined quite loosely in this article. In another sense, the therapeutic situation is a very special one. Particularly in psychoanalysis, but perhaps also to some extent in all therapies where the aims are exploratory rather than repressive, there are built-in mechanics which act as inductive forces toward regression. The precision with which these problems have to be faced depends, of course, on the nature of the questions one is trying to answer, but the issue is always , a ghost in the background, whether or not one attests to its presence in the design of a study. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - observational research KW - emotionally disturbed children KW - multiple settings KW - residential treatment KW - socialization KW - 1959 KW - Observation Methods KW - Residential Care Institutions KW - Treatment KW - Emotional Disturbances KW - Socialization KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00187.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39119-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Boomer, Donald S. T1 - SUBJECTIVE CERTAINTY AND RESISTANCE TO CHANGE. JO - Journal of Abnormal & Social Psychology JF - Journal of Abnormal & Social Psychology Y1 - 1959/05// VL - 58 IS - 3 M3 - Article SP - 323 EP - 328 SN - 0096851X AB - The article discusses a study which examined the relationship between subjects' expressed level of certainty during an experiment and their observable behavior. The study is concerned with the subjects' psychological bases for resisting or conforming to group influence. The study aims to tap subjects' private experience during the application of group pressure in order to learn more about the psychological processes involved. Subjects were undergraduate college students, drawn from a large lower division course in personal and social adjustment. KW - PSYCHOLOGY -- Research KW - RESISTANCE to change KW - PEER pressure in adolescence KW - SOCIAL influence KW - SOCIAL psychology KW - COLLEGE students KW - SOCIAL adjustment N1 - Accession Number: 24425270; Boomer, Donald S. 1; Affiliations: 1 : National Institute of Mental Health; Source Info: May1959, Vol. 58 Issue 3, p323; Subject Term: PSYCHOLOGY -- Research; Subject Term: RESISTANCE to change; Subject Term: PEER pressure in adolescence; Subject Term: SOCIAL influence; Subject Term: SOCIAL psychology; Subject Term: COLLEGE students; Subject Term: SOCIAL adjustment; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=24425270&site=ehost-live&scope=site DP - EBSCOhost DB - 24h ER - TY - JOUR AU - Kohn, Melvin L. T1 - SOCIAL CLASS AND THE EXERCISE OF PARENTAL AUTHORITY. JO - American Sociological Review JF - American Sociological Review Y1 - 1959/06// VL - 24 IS - 3 M3 - Article SP - 352 EP - 366 SN - 00031224 AB - The conditions under which middle- and working-class parents punish their pre-adolescent children physically, or refrain from doing so, appear to be quite different. Working-class parents are more likely to respond in terms of the immediate consequences of the child's actions, middle-class parents in terms of their interpretation of the child's intent in acting as he does. This reflects differences in parents' values: Working-class parents value for their children qualities that assure respectability; desirable behavior consists essentially of not violating proscriptions. Middle-class parents value the child's development of internalized standards of conduct; desirable behavior consists essentially of acting according to the dictates of one's own principles. The first necessarily focuses on the act itself, the second on the actor's intent. [ABSTRACT FROM AUTHOR] AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - SOCIAL classes KW - CHILD psychology KW - BEHAVIOR KW - CONDUCT of life KW - GUARDIAN & ward KW - PARENT & child (Law) N1 - Accession Number: 12581403; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun59, Vol. 24 Issue 3, p352; Subject Term: SOCIAL classes; Subject Term: CHILD psychology; Subject Term: BEHAVIOR; Subject Term: CONDUCT of life; Subject Term: GUARDIAN & ward; Subject Term: PARENT & child (Law); Number of Pages: 15p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12581403&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Hunt, G. Halsey AU - Akers, Robert P. AU - Mohler, Stanley R. T1 - Research grant program of the National Institutes of Health: With special emphasis on research in aging. JO - Geriatrics JF - Geriatrics Y1 - 1959/06// VL - 14 IS - 6 M3 - Article SP - 396 EP - 403 SN - 0016867X N1 - Accession Number: 20877918; Hunt, G. Halsey 1,2; Akers, Robert P. 1,3; Mohler, Stanley R. 1,3; Source Information: Jun1959, Vol. 14 Issue 6, p396; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3556 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20877918&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Pearlin, Leonard I. T1 - Social and Personal Stress and Escape Television Viewing. JO - Public Opinion Quarterly JF - Public Opinion Quarterly Y1 - 1959///Summer59 VL - 23 IS - 2 M3 - Article SP - 255 EP - 259 SN - 0033362X AB - This article focuses on television viewing and its role in relieving social and personal stress. People's reactions to the strains and stresses induced by their environments take many forms. Watching television, or at least watching certain types of television programs, appears to be the latest mode of response to stress. In modern society, the strains and dislocations that exist between the parts of the system make it unlikely that sizable segments of the population can remain untouched by stress and its consequences. It can be said without exaggeration that stress is a common feature of modern social life. An inquiry was directed specifically to the relationship between indicated escape needs of viewers and their viewing of television for escape purposes. Although most viewers occasionally turn to television for escape, it was expected that those who experienced relatively lasting and intense states of stress would be more typical. The article also presents an argument on the mass media and to the extent that they serve as a means of temporary diversion from tensions, militate against or defer actions that might be directed toward the source of difficulties. KW - Stress (Psychology) KW - Television viewers KW - Television programs KW - Mass media KW - Psychology KW - Vigilance (Psychology) N1 - Accession Number: 11947797; Pearlin, Leonard I. 1; Affiliations: 1: Sociologist staff of Laboratory Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Summer59, Vol. 23 Issue 2, p255; Thesaurus Term: Stress (Psychology); Thesaurus Term: Television viewers; Thesaurus Term: Television programs; Thesaurus Term: Mass media; Thesaurus Term: Psychology; Subject Term: Vigilance (Psychology); NAICS/Industry Codes: 512110 Motion Picture and Video Production; Number of Pages: 5p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11947797&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - JOUR ID - 2006-05978-009 AN - 2006-05978-009 AU - Carlson, V. R. T1 - LSD--A Pot of Gold? JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1959/06// VL - 4 IS - 6 SP - 174 EP - 175 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05978-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Carlson, V. R.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drugs; Lysergic Acid Diethylamide; Pharmacology. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Garattini, S. (Ed); Ghetti, V. (Ed). Psychotcopic Drugs=(Proceedings of the International Symposium on Psychotropic Drugs, Milan, 9-11 May 1957.) Amsterdam: Elsevier Publishing Co., 1957 (distributed by D. Van Nostrand, Princeton, N. J.). Pp. xiv + 606. $19.50; 1957. Page Count: 2. Issue Publication Date: Jun, 1959. AB - Reviews the book, Psychotcopic Drugs by S. Garattini and V. Ghetti (Eds.) (1957). This volume under review is an impressive, competent representation of current work with LSD and many other drugs, consisting of nearly fifty major presentations and an equal number of shorter reports by a total of 169 biochemists, pharmacologists, neurophysiologists, psychologists, and psychiatrists. By and large the book is not one for a reader with a casual interest. There is the protest that the effects of drugs are only superficially similar to more naturally occurring psychopathological changes; but lurking in this proposition lies the implication that experimental modifications of behavior can never really add anything new to existing behavioral theory. The lack of comparable drug experiments with persons represents an omission in the book under review, but the scarcity of such studies in general poses an opportunity and a challenge for both psychology and pharmacology. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychotcopic drugs KW - pharmacology KW - lysergic acid diethylamide KW - 1959 KW - Drugs KW - Lysergic Acid Diethylamide KW - Pharmacology KW - 1959 U2 - Garattini, S. (Ed); Ghetti, V. (Ed). (1957); Psychotcopic Drugs; (Proceedings of the International Symposium on Psychotropic Drugs, Milan, 9-11 May 1957.) Amsterdam: Elsevier Publishing Co., 1957 (distributed by D. Van Nostrand, Princeton, N. J.). Pp. xiv + 606. $19.50 DO - 10.1037/006067 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05978-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05979-015 AN - 2006-05979-015 AU - Birren, James E. T1 - How Skills Change as Men Mature. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1959/07// VL - 4 IS - 7 SP - 216 EP - 218 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05979-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Birren, James E.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Age Differences; Aging; Skill Learning. Classification: Gerontology (2860). Population: Human (10). Reviewed Item: Welford, A. T. Ageing and Human Skill=New York: Oxford University Press, for the Nuffield Foundation, 1958. Pp vi + 300. $4.00; 1958. Page Count: 3. Issue Publication Date: Jul, 1959. AB - Reviews the book, Ageing and Human Skill by A. T. Welford (see record [rid]1959-05884-000[/rid]). This book brought objectivity and scholarship into the research and thinking on aging and skilled behavior. This book is about aging and skill it is essential for a reviewer to ask what aging and skill meant to author and his staff. It is obvious in the studies that aging did not mean studying old people alone. The experiments included as subjects, adults of all ages, 'young' and 'old.' The word 'skill' may imply to some that author is interested in the things people do with their hands to earn money. The author is interested in skills of livelihood but 'skill' means much more to him, 'skill' is almost synonymous with the ubiquitous 'behavior'. Being predominantly interested in the performance of a task in the present moment, the author does not suggest biological or social manipulation to obviate age differences in performance but the varying of the nature of the tasks. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - skills change KW - age differences KW - aging KW - skilled behavior KW - 1959 KW - Age Differences KW - Aging KW - Skill Learning KW - 1959 U2 - Welford, A. T. (1958); Ageing and Human Skill; New York: Oxford University Press, for the Nuffield Foundation, 1958. Pp vi + 300. $4.00 DO - 10.1037/006094 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05979-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-40222-020 AN - 2013-40222-020 AU - Newman, Ruth G. T1 - The assessment of progress in the treatment of hyperaggressive children with learning disturbances within a school setting. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/07// VL - 29 IS - 3 SP - 633 EP - 643 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40222-020. Partial author list: First Author & Affiliation: Newman, Ruth G.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aggressive Behavior; Learning Ability; Teacher Personality; Therapeutic Processes. Minor Descriptor: Schools. Classification: Educational Psychology (3500). Population: Human (10); Male (30). Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Behaviior Scale. Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jul, 1959. AB - The emphasis in this report was largely placed on those determinants of an incident which arose in part or in whole from the school program itself its methods, materials, subject matter and teacher personality. Although it was observed by this descriptive method that the large majority of the determinants for incidents arose in the personality of the child himself, it was felt that where the school determined the outcome of an incident the data revealed clues concerning the use of material, subject matter, methods and teacher personality. These clues were felt to have implications for the teaching of hyperaggressive children, in general, even outside the more controlled total therapeutic residential setting reported on in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - hyperaggressive children KW - learning disturbances KW - school settings KW - therapeutic processes KW - teacher personality KW - 1959 KW - Aggressive Behavior KW - Learning Ability KW - Teacher Personality KW - Therapeutic Processes KW - Schools KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00231.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40222-020&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05980-013 AN - 2006-05980-013 AU - Noshpitz, Joseph D. T1 - The Troublesome Teenager. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1959/08// VL - 4 IS - 8 SP - 246 EP - 247 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05980-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Noshpitz, Joseph D.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Attitudes; Adolescent Development; Social Sciences. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Bloch, Herbert; Niederhoffer, Arthur. The Gang: A Study in Adolescent Behavior=New York: Philosophical Library, 1958. Pp. xv + 231. $6.00; 1958. Page Count: 2. Issue Publication Date: Aug, 1959. AB - Reviews the book, The Gang: A Study in Adolescent Behavior by Herbert Bloch and Arthur Niederhoffer (see record [rid]1959-00886-000[/rid]). A compact and meaty work that in 219 pages reviews social, cultural, psychological, and anthropological theories of adolescence and delinquency. On the whole, the book is pleasant to read. This reviewer thinks that its weakest element lies in its recommendation that the solution to society's increasing difficulty with its teenagers lies in giving these young people a clearly defined voice in the political activity of the nation-in enfranchising them in some manner. The authors do not merely review literature; they take a stand on many of the current issues in social science and practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - adolescent behavior KW - adolescent development KW - social science KW - 1959 KW - Adolescent Attitudes KW - Adolescent Development KW - Social Sciences KW - 1959 U2 - Bloch, Herbert; Niederhoffer, Arthur. (1958); The Gang: A Study in Adolescent Behavior; New York: Philosophical Library, 1958. Pp. xv + 231. $6.00 DO - 10.1037/006112 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05980-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39303-007 AN - 2013-39303-007 AU - Redl, Fritz T1 - The concept of a 'therapeutic milieu.' JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1959/10// VL - 29 IS - 4 SP - 721 EP - 736 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39303-007. Partial author list: First Author & Affiliation: Redl, Fritz; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Milieu Therapy; Psychotherapeutic Processes; Religious Practices; Therapeutic Community. Minor Descriptor: Geography. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 16. Issue Publication Date: Oct, 1959. AB - This article discusses, that speculations about the therapeutic value of the 'milieu' in which our patients live are neither as new nor as revolutionary as the enthusiasts, as well as the detractors of 'milieu therapy' occasionally want them to appear. The ritual interaction between patient and therapist is certainly sharply circumscribed. Even items such as horizontality of body posture and geographical placement of the analyst's chair are considered important conditions. The cry for the therapeutic milieu as a general slogan is futile and in this wide formulation the term doesn't mean a thing. The worst trap that explorers of the milieu idea sometimes seem to be goaded into is the ubiquitous use of the term 'therapeutic,' if it is coupled as an adjective, with 'milieu'; as a noun. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - therapeutic milieu KW - geographical placement KW - ritual interaction KW - patient and therapist interaction KW - 1959 KW - Milieu Therapy KW - Psychotherapeutic Processes KW - Religious Practices KW - Therapeutic Community KW - Geography KW - 1959 DO - 10.1111/j.1939-0025.1959.tb00243.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39303-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-05972-012 AN - 2006-05972-012 AU - Wispé, Lauren G. T1 - The Status Motive. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1959/11// VL - 4 IS - 11 SP - 362 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05972-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wispé, Lauren G.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Industrialization; Social Mobility; Society; Socioeconomic Status. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Lipset, Seymour Martin; Bendix, Reinhard. Social Mobility in Industrial Society=Berkeley: University of California Press, 1959. Pp. xxii + 309 $5 00; 1959. Page Count: 2. Issue Publication Date: Nov, 1959. AB - Reviews the book, Social Mobility in Industrial Society by Seymour Martin Lipset and Reinhard Bendix (1959). This volume is a veritable storehouse of empirical facts about social mobility and of carefully considered interpretations by theorists. These authors define social mobility as the process whereby individuals move from one stratum of society to another because of certain super-social forces like industrialization societies change and the demands made upon the occupants of the various occupational and social roles change. Throughout the social system members find themselves constrained to meet new obligations. Those who defect either through unwillingness or inability, open the way for new incumbents. Unintentional although it may have been, this book reflects the struggle of thousands of men and women to free themselves and their children from the forces of inurement, authority and prejudice. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - social mobility KW - status motive KW - industrialization KW - industrial society KW - 1959 KW - Industrialization KW - Social Mobility KW - Society KW - Socioeconomic Status KW - 1959 U2 - Lipset, Seymour Martin; Bendix, Reinhard. (1959); Social Mobility in Industrial Society; Berkeley: University of California Press, 1959. Pp. xxii + 309 $5 00 DO - 10.1037/005959 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05972-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Kohn, Melvin L. T1 - The Changing American Parent: A Study in the Detroit Area (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1959/12// VL - 24 IS - 6 M3 - Book Review SP - 902 EP - 903 SN - 00031224 AB - Reviews the book "The Changing American Parent: A Study in the Detroit Area,"by Daniel R. Miller and Guy E. Swanson. KW - PARENTS KW - NONFICTION KW - MILLER, Daniel R. KW - SWANSON, Guy E. KW - CHANGING American Parent: A Study in the Detroit Area, The (Book) N1 - Accession Number: 12813488; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Dec59, Vol. 24 Issue 6, p902; Subject Term: PARENTS; Subject Term: NONFICTION; Reviews & Products: CHANGING American Parent: A Study in the Detroit Area, The (Book); People: MILLER, Daniel R.; People: SWANSON, Guy E.; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12813488&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-00781-004 AN - 2006-00781-004 AU - Mishkin, Mortimer AU - Weiskrantz, Lawrence T1 - Effects of cortical lesions in monkeys on critical flicker frequency. JF - Journal of Comparative and Physiological Psychology JO - Journal of Comparative and Physiological Psychology JA - J Comp Physiol Psychol Y1 - 1959/12// VL - 52 IS - 6 SP - 660 EP - 666 CY - US PB - American Psychological Association SN - 0021-9940 N1 - Accession Number: 2006-00781-004. Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Mishkin, Mortimer; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Cortex; Critical Flicker Fusion Threshold; Monkeys. Classification: Animal Experimental & Comparative Psychology (2400); Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 1959. Copyright Statement: American Psychological Association. 1959. AB - The critical flicker frequencies of 12 monkeys were determined by a modified 'method of limits' before and after various cortical ablations. The results confirmed the prediction, based on studies of other visual functions in monkeys, that CFF in this species would not be impaired by anterior frontal lesions, but would be impaired by both inferotemporal and lateral occipital lesions. These findings are compared with the results of investigations of CFF in brain-injured men. Certain characteristics of the animals' performance provided evidence of the important influence of learning on the CFF. It is suggested that occipital and temporal lesions may have had deceptively similar effects on this function by interfering with sensory and learning mechanisms, respectively. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - cortical lesions KW - flicker frequency KW - monkeys KW - 1959 KW - Cerebral Cortex KW - Critical Flicker Fusion Threshold KW - Monkeys KW - 1959 DO - 10.1037/h0038577 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00781-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Heller, John R. T1 - Recent developments in research on cancer. JO - Geriatrics JF - Geriatrics Y1 - 1960/01// VL - 15 IS - 1 M3 - Article SP - 1 EP - 10 SN - 0016867X N1 - Accession Number: 20789589; Heller, John R. 1,2; Source Information: Jan1960, Vol. 15 Issue 1, p1; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 4107 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20789589&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - CHAP ID - 2013-25223-003 AN - 2013-25223-003 AU - Alexander, Irving E. AU - Adlerstein, Arthur M. ED - David, Henry P. ED - Brengelmann, J. C. ED - David, Henry P., (Ed) ED - Brengelmann, J. C., (Ed) T1 - Studies in the psychology of death. T2 - Perspectives in personality research. Y1 - 1960/// SP - 65 EP - 92 CY - New York, NY, US PB - Springer Publishing Co N1 - Accession Number: 2013-25223-003. Partial author list: First Author & Affiliation: Alexander, Irving E.; Training Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20131028. Correction Date: 20140512. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Death and Dying; Psychology. Classification: Personality Traits & Processes (3120). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Tucker Goals of Life Inventory; Cattell Manifest Anxiety Scale; Word Association Task; Rotter Incomplete Sentences Blank. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 28. AB - Each man learns early in life that some day he must die. What role does this information play in his development? How does it affect his aims, his wishes, his behavior? At the present time our best sources of information on these questions are outside the field of psychology—in literature, philosophy, religion, and medicine. While such sources have yielded rich insights about the meaning that death has for human beings, there has been little attempt to apply scientific procedures to select among these ideas. Perhaps it is time for this further step to be taken. It is the purpose of this chapter to describe some primitive attempts, utilizing the more traditional techniques and methods of our science, to study some aspects of man's reaction to death. First let us glance briefly at the state of our knowledge about death as it exists in the psychological literature. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychology KW - death KW - 1960 KW - Death and Dying KW - Psychology KW - 1960 U1 - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated DO - 10.1037/14410-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-25223-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 1960-08158-004 AN - 1960-08158-004 AU - Kety, Seymour S. ED - Jackson, Don D. ED - Jackson, Don D., (Ed) T1 - Recent Biochemical Theories of Schizophrenia. T2 - The etiology of schizophrenia. Y1 - 1960/// SP - 120 EP - 145 CY - Oxford, England PB - Basic Books N1 - Accession Number: 1960-08158-004. Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Clinical Science, National Institute of Mental Health, US. Release Date: 19600501. Publication Type: Book (0200). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Biochemistry; Schizophrenia; Theories. Minor Descriptor: Etiology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26. AB - The concept of a chemical etiology in schizophrenia is not new. Earlier biochemical theories and findings related to schizophrenia have been reviewed by a number of authors. It is the purpose of this review to describe the biochemical trends in schizophrenia research of the past few years, to discuss current theories, and to examine the evidence that has been used to support them. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - schizophrenia research KW - biochemical theories KW - 1960 KW - Biochemistry KW - Schizophrenia KW - Theories KW - Etiology KW - 1960 DO - 10.1037/10605-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-08158-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-41274-011 AN - 2013-41274-011 AU - Dittmann, Allen T. T1 - The psychotherapeutic function of the orthopsychiatric team: Report of the Committee on Psychotherapy: Panel, 1959: 6. The need for ongoing research in the general function of the orthopsychiatric team. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1960/01// VL - 30 IS - 1 SP - 79 EP - 86 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-41274-011. Partial author list: First Author & Affiliation: Dittmann, Allen T.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinics; Health Care Services; Orthopsychiatry; Psychotherapy. Minor Descriptor: Teams. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 8. Issue Publication Date: Jan, 1960. AB - This article speculate on what we should do next in trying to find out how psychotherapy is practiced in clinics throughout the country. To my mind the trouble with the work we've done so far is that it has been successful in giving us some partial answers to our questions. The final report is extensive, carefully thought out, and bears rereading, or first reading, as the case may be. From the standpoint of our present discussion, however, it is the contrast between the visits and the questionnaire. The findings of a survey about psychotherapy in orthopsychiatric clinics, then, would have widespread interest not only to our organization, but to the professions which our members represent. This interest, of course, is our interest in the long run, and it would be well if it could be served with data which can be taken seriously. The time has passed when hunches, hearsay and opinion about orthopsychiatric practice can suffice. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - orthopsychiatric teams KW - ongoing research KW - clinics KW - health services KW - psychotherapy KW - 1960 KW - Clinics KW - Health Care Services KW - Orthopsychiatry KW - Psychotherapy KW - Teams KW - 1960 DO - 10.1111/j.1939-0025.1960.tb03012.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41274-011&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Campbell, John D. T1 - The Psychology of Affiliation: Experimental Studies of the Sources of Gregariousness (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1960/02// VL - 25 IS - 1 M3 - Book Review SP - 130 EP - 131 SN - 00031224 AB - Reviews the book "The Psychology of Affiliation: Experimental Studies of the Sources of Gregariousness," by Stanley Schachter. KW - SOCIAL isolation KW - NONFICTION KW - SCHACHTER, Stanley KW - PSYCHOLOGY of Affiliation: Experimental Studies of the Sources of Gregariousness, The (Book) N1 - Accession Number: 12785989; Campbell, John D. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Feb60, Vol. 25 Issue 1, p130; Subject Term: SOCIAL isolation; Subject Term: NONFICTION; Reviews & Products: PSYCHOLOGY of Affiliation: Experimental Studies of the Sources of Gregariousness, The (Book); People: SCHACHTER, Stanley; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12785989&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Birren, James E. T1 - PSYCHOLOGICAL ASPECTS OF AGING. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1960/02// VL - 11 IS - 1 M3 - Article SP - 161 EP - 198 PB - Annual Reviews Inc. SN - 00664308 AB - Focuses on the psychological aspects of aging. Analysis of socio-cultural influences on aging; Significance of health surveys of the older adults; Interpretation of neuropsychological factors in relation to psychiatric disturbances. KW - AGING -- Psychological aspects KW - NEUROPHYSIOLOGY KW - HEALTH surveys KW - PSYCHOPHYSIOLOGY N1 - Accession Number: 11266867; Birren, James E. 1; Affiliations: 1: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p161; Subject Term: AGING -- Psychological aspects; Subject Term: NEUROPHYSIOLOGY; Subject Term: HEALTH surveys; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 38p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11266867&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Rubenstein, Herbert AU - Aborn, Murray T1 - PSYCHOLINGUISTICS. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1960/02// VL - 11 IS - 1 M3 - Article SP - 291 EP - 322 PB - Annual Reviews Inc. SN - 00664308 AB - Focuses on various aspects of psycholinguistics. Relationship between the probability of language segments and behaviors; Significance of word association in common language experience; Importance of equipments for analyzing and synthesizing speech. KW - PSYCHOLINGUISTICS KW - HUMAN behavior KW - LANGUAGE & languages KW - SPEECH N1 - Accession Number: 11267426; Rubenstein, Herbert 1; Aborn, Murray 2; Affiliations: 1: Operational Applications Laboratory, Air Forte Cambridge Research Center, Bedford, Massachusetts.; 2: Division of Research Grants, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p291; Subject Term: PSYCHOLINGUISTICS; Subject Term: HUMAN behavior; Subject Term: LANGUAGE & languages; Subject Term: SPEECH; Number of Pages: 32p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11267426&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Ross, Sherman AU - Cole, Jonathan 0. T1 - PSYCHOPHARMACOLOGY. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1960/02// VL - 11 IS - 1 M3 - Article SP - 415 EP - 438 PB - Annual Reviews Inc. SN - 00664308 AB - Focuses on the efforts of developments in psychopharmacology. Role of traditional drugs in clinical treatment; Significance of psychotomimetic agents in psychiatric treatment; Effects of these drugs on human behavior. KW - RESEARCH KW - PSYCHOPHARMACOLOGY KW - PSYCHIATRIC drugs KW - HUMAN behavior N1 - Accession Number: 11267444; Ross, Sherman 1; Cole, Jonathan 0. 2; Affiliations: 1: University of Maryland, College Park, Maryland.; 2: Psychopharmacology Service center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1960, Vol. 11 Issue 1, p415; Thesaurus Term: RESEARCH; Subject Term: PSYCHOPHARMACOLOGY; Subject Term: PSYCHIATRIC drugs; Subject Term: HUMAN behavior; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 24p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11267444&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-05987-009 AN - 2006-05987-009 AU - Singer, Jerome L. T1 - What Do We Know of Projective Techniques? JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1960/03// VL - 5 IS - 3 SP - 76 EP - 77 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05987-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Singer, Jerome L.; National Institute of Mental Health, US. Release Date: 20061023. Correction Date: 20120409. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Personality Change; Personality Development; Projective Techniques. Classification: Personality Psychology (3100). Population: Human (10). Reviewed Item: Harrower, Molly. Personality Change and Development: As Measured by the Projective Techniques=New York: Grune & Stratton, 1958. Pp. 383. $10.00; 1958. Page Count: 2. Issue Publication Date: Mar, 1960. AB - Reviews the book, Personality Change and Development: As Measured by the Projective Techniques by Molly Harrower (see record [rid]2008-13301-000[/rid]). Do projective techniques actually reflect personality changes otherwise observable through life adjustment or from therapists' evaluations? Dr. Molly Harrower has sought at least an approach to answering some of the cogent queries which she poses at the outset of her new book. The Summary was obviously developed with considerable awareness of the dimensions which are relevant to psychotherapists and which can therefore, with slight modifications, be also employed for obtaining independent evaluations by therapists. Dr. Harrower goes on to note the rather striking fluctuations in responses upon successive testing but provides some clinical illustrations of both quantitative and configurational similarity in the records. The main body of this volume deals with comparisons of pretesting and posttesting and Test Summary Scores. While Dr. Harrower's conclusions will not be too surprising to most experienced clinicians, there is the danger that they may be too encouraging, as the author herself notes. Dr Harrower has raised some cogent issues and has indeed pointed to certain techniques and methods for answering these questions, even though her own data fail to yield conviction. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - projective techniques KW - personality changes KW - personality development KW - 1960 KW - Personality Change KW - Personality Development KW - Projective Techniques KW - 1960 U2 - Harrower, Molly. (1958); Personality Change and Development: As Measured by the Projective Techniques; New York: Grune & Stratton, 1958. Pp. 383. $10.00 DO - 10.1037/006254 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05987-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-40224-002 AN - 2013-40224-002 AU - Bell, Richard Q. AU - Garmezy, Norman AU - Farina, Amerigo AU - Rodnick, Eliot. H. T1 - Direct study of child-parent interactions: Workshop, 1959: 1. The structured situational test: A method for studying family interaction in schizophrenia. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1960/07// VL - 30 IS - 3 SP - 445 EP - 452 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40224-002. Partial author list: First Author & Affiliation: Bell, Richard Q.; Laboratory of Psychology, National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Psychology; Collaboration; Schizophrenia. Minor Descriptor: Family; Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1960. AB - The purpose of this paper is to present data obtained from a study of parents of schizophrenic patients in which a technique was employed-the structured situational test-to circumvent many of the difficulties which have been described. This method involves the observation of actual behavior in response to uniform stimulus situations. The situations which are kept open-ended, provide for a wide range of behavior variation and disguise of what is being measured. This last point is particularly important in view of the reported defensiveness of parents of schizophrenic patients. Nevertheless, the study of parent-patient interaction is a necessary future step. The decision to embark upon such research will, however, require appropriate institutional safeguards. The investigator in this area should possess an amalgam of clinical maturity, experimental sophistication and breadth of experience in psychopathology. It is in this experimental area of the systematic study of parent patient interaction that the collaborative efforts of the sophisticated psychotherapist and the equally sophisticated experimentalist may prove most fruitful. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - child-parent interactions KW - clinical maturity KW - collaborative efforts KW - parent-patient interaction KW - schizophrenic patients KW - 1960 KW - Clinical Psychology KW - Collaboration KW - Schizophrenia KW - Family KW - Parents KW - 1960 U1 - Sponsor: National Institute of Mental Health, US. Grant: M-629. Recipients: No recipient indicated DO - 10.1111/j.1939-0025.1960.tb02060.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40224-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-40224-016 AN - 2013-40224-016 AU - Newman, Ruth T1 - The way back: Extramural schooling as a transitional phase of residential therapy. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1960/07// VL - 30 IS - 3 SP - 588 EP - 598 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40224-016. Partial author list: First Author & Affiliation: Newman, Ruth; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ego; Residential Care Institutions; Therapeutic Processes. Minor Descriptor: Emotional Disturbances; Schools. Classification: Educational Psychology (3500). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Jul, 1960. AB - This report is concerned with a transitional phase in the treatment of children who have been institutionalized because of severe behavioral and emotional disturbances. There arrives a time when a confined environment is neither necessary nor beneficial. At this point, the children need a carefully planned expansion of their lives while they still remain in a protective, therapeutic environment. Thus, their response to the increasing demands of their widened horizon can be handled, investigated and treated. School is society for a child. I t is his work life, a barometer of his ego strengths and weaknesses. Therefore, a major aspect of the transitional treatment phase consists in the selection of appropriate schools ; the working out of methods for helping a child to maintain himself constructively in school as well as to recognize and cope with the anxiety engendered and the problems that arise. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - extramural schooling KW - ego strengths KW - emotional disturbances KW - residential therapy KW - therapeutic environment KW - transitional treatment phase KW - 1960 KW - Ego KW - Residential Care Institutions KW - Therapeutic Processes KW - Emotional Disturbances KW - Schools KW - 1960 DO - 10.1111/j.1939-0025.1960.tb02074.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40224-016&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR T1 - DISTANCE AND CONFORMITY IN CONTINUOUS SOCIAL INFLUENCE INTERACTIONS. AU - Zolman, James F. AU - Wolf, Irvin S. AU - Fisher, Seymour JO - Journal of Social Psychology JF - Journal of Social Psychology Y1 - 1960/08// VL - 52 IS - 2 SP - 251 EP - 258 SN - 00224545 N1 - Accession Number: 16520648; Author: Zolman, James F.: 1 Author: Wolf, Irvin S.: 1 Author: Fisher, Seymour: 1 ; Author Affiliation: 1 Denison University and the National Institute of Mental Health.; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20050325 N2 - The article focuses on distance and conformity in continuous social influence interactions. An experiment was carried out, which was a continuation of research aimed at specifying the relations between measures of social influence (movement and conformity) and distance (size of discrepancy) in continuous social interaction situations. Pairs of "Ss" were required to judge the number of paratroopers seen in two successively exposed photographs. By manipulating the amount of intertrial influence between the two photographs, it was possible to vary experimentally the distance each of three groups received on the second photograph. The results indicate that movement and conformity in a second interaction are contingent upon distance as in the initial interaction. \Within the distance range covered, in both interactions conformity was found to be a decreasing monotonic function of distance. KW - *SOCIAL psychology KW - SOCIAL influence KW - CONFORMITY KW - PHOTOGRAPHS KW - SOCIAL interaction KW - PRESTIGE UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=16520648&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR AU - Butler, Robert N. T1 - Intensive psychotherapy for the hospitalized aged. JO - Geriatrics JF - Geriatrics Y1 - 1960/09// VL - 15 IS - 9 M3 - Article SP - 644 EP - 653 SN - 0016867X N1 - Accession Number: 20879016; Butler, Robert N. 1,2; Source Information: Sep1960, Vol. 15 Issue 9, p644; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 5071 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20879016&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Dorn, Harold F. T1 - The Influence of Non-Govermental Groups on Foreign Policy-Making/Americans in World Affairs/Opinion Leaders in American Communities. JO - American Sociological Review JF - American Sociological Review Y1 - 1960/10// VL - 25 IS - 5 M3 - Book Review SP - 776 EP - 777 SN - 00031224 AB - Reviews two books about foreign affairs. "The Influence of Non-Govermental Groups on Foreign Policy-Making," by Bernard C. Cohen, foreword by Max F. Millikan; "Americans in World Affairs," by Alfred O. Hero, foreword by Max F. Millikan; "Opinion Leaders in American Communities," by Alfred O. Hero, foreword by Max F. Millikan. KW - INTERNATIONAL relations KW - NONFICTION KW - COHEN, Bernard C. KW - MILLIKAN, Max F. KW - HERO, Alfred O. KW - INFLUENCE of Non-Govermental Groups on Foreign Policy-Making, The (Book) KW - AMERICANS in World Affairs (Book) KW - OPINION Leaders in American Communities (Book) N1 - Accession Number: 12801202; Dorn, Harold F. 1; Affiliations: 1: National Institutes of Health; Issue Info: Oct60, Vol. 25 Issue 5, p776; Thesaurus Term: INTERNATIONAL relations; Subject Term: NONFICTION; Reviews & Products: INFLUENCE of Non-Govermental Groups on Foreign Policy-Making, The (Book); Reviews & Products: AMERICANS in World Affairs (Book); Reviews & Products: OPINION Leaders in American Communities (Book); NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 911410 Foreign affairs; People: COHEN, Bernard C.; People: MILLIKAN, Max F.; People: HERO, Alfred O.; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12801202&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Dorn, Harold F. T1 - Elements of Vital Statistics. JO - American Sociological Review JF - American Sociological Review Y1 - 1960/10// VL - 25 IS - 5 M3 - Book Review SP - 777 EP - 777 SN - 00031224 AB - Reviews the book "Elements of Vital Statistics," by Bernard Benjamin. KW - VITAL statistics KW - NONFICTION KW - BENJAMIN, Bernard KW - ELEMENTS of Vital Statistics (Book) N1 - Accession Number: 12801203; Dorn, Harold F. 1; Affiliations: 1: National Institutes of Health; Issue Info: Oct60, Vol. 25 Issue 5, p777; Thesaurus Term: VITAL statistics; Subject Term: NONFICTION; Reviews & Products: ELEMENTS of Vital Statistics (Book); People: BENJAMIN, Bernard; Number of Pages: 2/3p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12801203&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-05984-010 AN - 2006-05984-010 AU - Dittmann, Allen T. T1 - Systematic Psychoanalysis as Research. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1960/11// VL - 5 IS - 11 SP - 366 EP - 367 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-05984-010. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Allen T.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychoanalysis; Psychodynamics; Psychotherapy. Minor Descriptor: Mental Disorders; Psychosis; Schizophrenia. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Bullard, Dexter M. (Ed). Psychoanalysis and Psychotherapy: Selected Papers of Frieda Fromm-Reichmann=Chicago: University of Chicago Press, 1959. Pp. xiv + 350. $7.50; 1959. Page Count: 2. Issue Publication Date: Nov, 1960. AB - Reviews the book, Psychoanalysis and Psychotherapy: Selected Papers of Frieda Ftomm- Reichmann edited Dexter M. Bullard (see record [rid]1960-04550-000[/rid]). This book is a selection of 23 of Fromm-Reichmann's papers published between 1935 and 1959 which treats among other subjects: (a) the philosophy of mental disorder and the history and philosophy of psychotherapy; (b) the problems and advances in psychoanalysis and psychotherapy with psychotics; (c) the psychodynamics and therapy of schizophrenia. This book was compiled by her colleagues, friends, and students as an expression of their wish 'to preserve and concentrate Frieda Fromm-Reichmann's thoughts and ideas.' (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychoanalysis KW - psychotherapy KW - mental disorder KW - psychotics KW - psychodynamics KW - schizophrenia KW - 1960 KW - Psychoanalysis KW - Psychodynamics KW - Psychotherapy KW - Mental Disorders KW - Psychosis KW - Schizophrenia KW - 1960 U2 - Bullard, Dexter M. (Ed). (1959); Psychoanalysis and Psychotherapy: Selected Papers of Frieda Fromm-Reichmann; Chicago: University of Chicago Press, 1959. Pp. xiv + 350. $7.50 DO - 10.1037/006205 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05984-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Caudill, William T1 - The Culture of the State Mental Hospital (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1960/12// VL - 25 IS - 6 M3 - Book Review SP - 981 EP - 981 SN - 00031224 AB - Reviews the book "The Culture of the State Mental Hospital," by H. Warren Dunham and S. Kirson Weinberg. KW - PSYCHIATRIC hospitals KW - NONFICTION KW - DUNHAM, H. Warren KW - WEINBERG, S. Kirson KW - CULTURE of the State Mental Hospital, The (Book) N1 - Accession Number: 12875448; Caudill, William 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Dec60, Vol. 25 Issue 6, p981; Thesaurus Term: PSYCHIATRIC hospitals; Subject Term: NONFICTION; Reviews & Products: CULTURE of the State Mental Hospital, The (Book); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; People: DUNHAM, H. Warren; People: WEINBERG, S. Kirson; Number of Pages: 3/4p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12875448&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2013-40694-004 AN - 2013-40694-004 AU - Dysinger, Robert H. T1 - The family as the unit of study and treatment: Workshop, 1959: 2. A family perspective on the diagnosis of individual members. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1961/01// VL - 31 IS - 1 SP - 61 EP - 68 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40694-004. Partial author list: First Author & Affiliation: Dysinger, Robert H.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diagnosis; Emotional Disturbances; Family Therapy; Psychosis. Minor Descriptor: Individualism; Parental Attitudes; Treatment. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 8. Issue Publication Date: Jan, 1961. AB - The observations described here may be used as a basis for venturing one kind of statement that would attempt to recognize the problem at a family level. Could it be that the situation is something like this? An intense emotional problem in the parental relationship has long been handled through a complicated and subtle set of mechanisms that operate to support an inaccurate assumption and action consistent with it that this problem is one of the health of one child. The inefficiency of this chronic displacement as a mode of family adjustment becomes openly manifest with the development of the psychosis. At the same time the psychosis lends itself to being seen as a living confirmation of the accuracy of the assumption, and can become a focus for the perpetuation of the family mechanism. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - treatment units KW - family KW - individual members KW - diagnosis KW - parental relationships KW - emotional problems KW - psychosis KW - 1961 KW - Diagnosis KW - Emotional Disturbances KW - Family Therapy KW - Psychosis KW - Individualism KW - Parental Attitudes KW - Treatment KW - 1961 DO - 10.1111/j.1939-0025.1961.tb02107.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40694-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-40694-006 AN - 2013-40694-006 AU - Basamania, Betty W. T1 - The family as the unit of study and treatment: Workshop, 1959: 4. The emotional life of the family: Inferences for social casework. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1961/01// VL - 31 IS - 1 SP - 74 EP - 86 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40694-006. Partial author list: First Author & Affiliation: Basamania, Betty W.; Family Study Section, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Adjustment; Family Relations; Family Therapy; Treatment. Minor Descriptor: Diagnosis; Social Casework. Classification: Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. Page Count: 13. Issue Publication Date: Jan, 1961. AB - This paper will present a casework view of the project’s particular approach to the family as a unit to illustrate the contribution such an approach can make toward the diagnosis and treatment of that unit. The approach was to regard the family unit as a single organism. In the following sections there will be a discussion of observations made as a result of seeing the family together, treatment of the family unit, and the inferences this approach has for social casework. Observations included in this paper were selected on the basis of repetitive behavior manifestations, seen in each of the 11 families. The characteristics noted as significant within the families were also experienced by the staff in relating to the families. The observations were made as a result of seeing the family as a unit, and would have been much less clear, if not obscured, if family members had been seen individually. These observations were not all-inclusive of the data of this study but were outstanding in the effort to understand the functioning of these families with a particular kind of problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - treatment processes KW - emotional life KW - family dynamics KW - diagnosis KW - family therapy KW - social work KW - 1961 KW - Emotional Adjustment KW - Family Relations KW - Family Therapy KW - Treatment KW - Diagnosis KW - Social Casework KW - 1961 DO - 10.1111/j.1939-0025.1961.tb02109.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40694-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Mohler, Stanley R. T1 - Aging and pilot performance. JO - Geriatrics JF - Geriatrics Y1 - 1961/02// VL - 16 IS - 2 M3 - Article SP - 82 EP - 88 SN - 0016867X N1 - Accession Number: 17810157; Mohler, Stanley R. 1; Source Information: Feb1961, Vol. 16 Issue 2, p82; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3287 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17810157&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Caudill, William T1 - AROUND THE CLOCK PATIENT CARE IN JAPANESE PSYCHIATRIC HOSPITALS: THE ROLE OF THE TSUKISOI. JO - American Sociological Review JF - American Sociological Review Y1 - 1961/04// VL - 26 IS - 2 M3 - Article SP - 204 EP - 214 SN - 00031224 AB - Tsukisoi are sub-professional nurses who, in private psychiatric hospitals in Japan, are assigned on a one-to-one basis to patients. The tsukisoi cares for the patient continuously throughout his hospitalization. The work of this role group and its place in the social structure of the hospital are described. Correspondences are drawn between the behavior of the tsukisoi in her technical role and the behavior exhibited in more general roles, such as that of mother, in Japanese culture. The position of the tsukisoi in the power structure of the hospital is seen in relation to the structure of power groupings in organizations such as the Japanese company or factory. Some of the wider sociological and psychodynamic implications of the role of the tsukisoi are discussed. [ABSTRACT FROM AUTHOR] AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - NURSES KW - PSYCHIATRIC hospitals KW - HOSPITAL care KW - PATIENTS KW - PSYCHODYNAMICS KW - JAPAN N1 - Accession Number: 12768725; Caudill, William 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Apr61, Vol. 26 Issue 2, p204; Thesaurus Term: NURSES; Thesaurus Term: PSYCHIATRIC hospitals; Subject Term: HOSPITAL care; Subject Term: PATIENTS; Subject Term: PSYCHODYNAMICS; Subject: JAPAN; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 11p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12768725&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Kohn, Melvin L. T1 - The Social Epidemiology of Mental Disorders--A Psychiatric Survey of Texas. JO - American Sociological Review JF - American Sociological Review Y1 - 1961/06// VL - 26 IS - 3 M3 - Book Review SP - 493 EP - 494 SN - 00031224 AB - Reviews the book "The Social Epidemiology of Mental Disorders--A Psychiatric Survey of Texas," by E. Gartly Jaco. KW - MENTAL illness KW - NONFICTION KW - JACO, E. Gartly KW - SOCIAL Epidemiology of Mental Disorders: A Psychiatric Survey of Texas, The (Book) N1 - Accession Number: 12785835; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun61, Vol. 26 Issue 3, p493; Subject Term: MENTAL illness; Subject Term: NONFICTION; Reviews & Products: SOCIAL Epidemiology of Mental Disorders: A Psychiatric Survey of Texas, The (Book); People: JACO, E. Gartly; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12785835&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-06025-005 AN - 2006-06025-005 AU - Bergman, Paul T1 - Has Psychoanalysis Become Too Complacent? JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1961/08// VL - 6 IS - 8 SP - 265 EP - 266 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06025-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Psychoanalysis; Psychoanalytic Training. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Reviewed Item: Lewin, Bertram D.; Ross, Helen. Psychoanalytic Education in the United States=New York: W. W. Norton, 1960. Pp. xviii + 478. $10.00; 1960. Page Count: 2. Issue Publication Date: Aug, 1961. AB - Reviews the book, Psychoanalytic Education in the United States by Bertram D. Lewin and Helen Ross (see record [rid]1961-06514-000[/rid]). If you are interested in critical comment on current practices, you will find that, up to a certain point the authors' report within local groups, habits of thinking which they consider all too empirical, they are not satisfied with the conformity and the lack of clarity which they see at times, they decry the scarcity of creative freedom in teaching. On the other hand, they think that 'it is evident that it is now known what should be covered' in the curriculum. At any rate, the authors do not point to the desirability of judging psychoanalytic education by how effectively it prepares for the business of therapy. The magic circle of that spirit seems also to have captivated the authors of this book. Wholly preoccupied with the technicalities of training psychoanalysts, they neglect to take a bearing on the values toward which the endeavor should be guided. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychoanalysis KW - psychoanalytic education KW - curriculum KW - US KW - 1961 KW - Curriculum KW - Psychoanalysis KW - Psychoanalytic Training KW - 1961 U2 - Lewin, Bertram D.; Ross, Helen. (1960); Psychoanalytic Education in the United States; New York: W. W. Norton, 1960. Pp. xviii + 478. $10.00 DO - 10.1037/006669 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06025-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Suster, E. AU - Kirsanow, Eugene M. T1 - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions. JO - Immunology JF - Immunology Y1 - 1961/10// VL - 4 IS - 4 M3 - Article SP - 354 EP - 365 SN - 00192805 AB - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR] AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - ENDOTOXINS KW - IMMUNE response KW - MYCOBACTERIA KW - BACTERIAL toxins KW - ANTIGEN-antibody reactions KW - MICE as carriers of disease KW - IMMUNOLOGY N1 - Accession Number: 12534120; Suster, E. 1,2; Kirsanow, Eugene M. 1,2; Source Information: Oct61, Vol. 4 Issue 4, p354; Subject: ENDOTOXINS; Subject: IMMUNE response; Subject: MYCOBACTERIA; Subject: BACTERIAL toxins; Subject: ANTIGEN-antibody reactions; Subject: MICE as carriers of disease; Subject: IMMUNOLOGY; Number of Pages: 12p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=12534120&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2006-00786-007 AN - 2006-00786-007 AU - Stricker, George T1 - Word values, word frequency, and visual duration thresholds: A comment. JF - Psychological Review JO - Psychological Review JA - Psychol Rev Y1 - 1961/11// VL - 68 IS - 6 SP - 420 EP - 422 CY - US PB - American Psychological Association SN - 0033-295X SN - 1939-1471 N1 - Accession Number: 2006-00786-007. Partial author list: First Author & Affiliation: Stricker, George; National Institute of Mental Health, United States Public Health Service, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Semantic Differential; Thresholds; Visual Acuity; Word Frequency. Minor Descriptor: Words (Phonetic Units). Classification: Human Experimental Psychology (2300). References Available: Y. Page Count: 3. Issue Publication Date: Nov, 1961. Copyright Statement: American Psychological Association. 1961. AB - Comments on an article by Johnson, Thomson, and Frincke (see record [rid]2005-10341-002[/rid]). Johnson, Thomson, and Frincke's interpretation of their work with regard to the interrelationships of word value and word frequency was questioned on the basis of their use of the good-bad scale of the semantic differential as an operational definition of word value. Reference to pertinent previous studies seemed to indicate that word value has a directly motivational connotation while the evaluative dimension of the semantic differential is sensitive to an attitudinal, cognitive component of behavior. An examination of their interpretations of their experimental evidence revealed a failure to take this distinction into account. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - word values KW - word frequency KW - visual duration thresholds KW - interrelationships KW - semantic differential KW - 1961 KW - Semantic Differential KW - Thresholds KW - Visual Acuity KW - Word Frequency KW - Words (Phonetic Units) KW - 1961 DO - 10.1037/h0039126 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00786-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Rosenberg, Morris T1 - Variations in Value Orientations. JO - American Sociological Review JF - American Sociological Review Y1 - 1961/12// VL - 26 IS - 6 M3 - Book Review SP - 936 EP - 937 SN - 00031224 AB - Reviews the book "Variations in Value Orientations," by Florence Rockwood Kluchhohn and Fred L. Strodtbeck. KW - SOCIAL values KW - NONFICTION KW - STRODTBECK, Fred L. KW - KLUCHHOHN, Florence KW - VARIATIONS in Value Orientations (Book) N1 - Accession Number: 12819628; Rosenberg, Morris 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Dec61, Vol. 26 Issue 6, p936; Subject Term: SOCIAL values; Subject Term: NONFICTION; Reviews & Products: VARIATIONS in Value Orientations (Book); People: STRODTBECK, Fred L.; People: KLUCHHOHN, Florence; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12819628&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Pearlin, Leonard I. T1 - THE APPEALS OF ANONYMITY IN QUESTIONNAIRE RESPONSE. JO - Public Opinion Quarterly JF - Public Opinion Quarterly Y1 - 1961///Winter61/62 VL - 25 IS - 4 M3 - Article SP - 640 EP - 647 SN - 0033362X AB - The circulation of questionnaires to strangers always involves a mixture of etiquette and expediency. Here is a study which challenges the usual assumption that the questionnaires must remain anonymous to ensure candidness and enhance the validity of the responses. However, it points out that the preservation of anonymity may be advantageous for other reasons. It has become standard practice in much social and psychological research to guarantee anonymity to respondents. This is easily done where respondent identification is not needed. Offering safeguards of anonymity to respondents is common in social and psychological research. Anonymity is extended to ensure a high level of voluntary participation or, where participation is mandatory, to minimize haloed and invalid responses. In each case, the assumption is made that there are questions which, if answered candidly, would place respondents in a position of fear and worry. People who held positive opinions on presumably fear-arousing issues were no more likely to sign than those who held negative opinions. Anonymity can derive from social and personal characteristics of respondents as well as from the character of the questions that are asked. KW - Questionnaires KW - Etiquette KW - Social participation KW - Conduct of life KW - Psychology -- Research N1 - Accession Number: 11962217; Pearlin, Leonard I. 1; Affiliations: 1: Social Science Analyst, staff of Laboratory of Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Winter61/62, Vol. 25 Issue 4, p640; Thesaurus Term: Questionnaires; Subject Term: Etiquette; Subject Term: Social participation; Subject Term: Conduct of life; Subject Term: Psychology -- Research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 8p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11962217&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - AU - Kagan, Jerome1 AU - Moss, Howard A.2 T1 - Personality and Social Development: Family and Peer Influences. JO - Review of Educational Research JF - Review of Educational Research J1 - Review of Educational Research PY - 1961/12// Y1 - 1961/12// VL - 31 IS - 5 CP - 5 M3 - Article SP - 463 EP - 474 SN - 00346543 AB - This article identifies the consideration of the research in the long-term stability of selected behaviors and will continue with a discussion of the influence of parents and peers on the behavior of the child and the adolescent. Suggested that dependent behavior violated sex-role standards for males and that dependent boys learned to inhibit the behavior as they matured. A dependent posture was more congruent with traditional female sex-role standards and the dependent girl was not highly pressured into inhibiting the response. It also identified the degree of adoption of traditional masculine or feminine sex-role interests among adolescent boys. KW - Teenagers KW - Behavior KW - Parents KW - Children -- Attitudes KW - Gender role KW - Teenage boys N1 - Accession Number: 18812150; Authors: Kagan, Jerome 1; Moss, Howard A. 2; Affiliations: 1: Fels Research Institute, Yellow Springs, Ohio; 2: National Institute of Mental Health, Bethesda, Maryland; Subject: Behavior; Subject: Parents; Subject: Children -- Attitudes; Subject: Gender role; Subject: Teenage boys; Subject: Teenagers; Number of Pages: 12p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=18812150&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - AU - Birren, James F.1 AU - Jerome, Edward A.1 AU - Chown, Sheila M.2 T1 - Aging and Psychological Adjustment: Problem Solving and Motivation. JO - Review of Educational Research JF - Review of Educational Research J1 - Review of Educational Research PY - 1961/12// Y1 - 1961/12// VL - 31 IS - 5 CP - 5 M3 - Article SP - 487 EP - 499 SN - 00346543 AB - This article focuses on the development psychology of the aging. Its primary objective was to integrate information and explain the manifest changes which occur in the aging individual. Reviewed the aspects of the aging individual as sensation and perception, emotions, learning, intelligence, interests and attitudes, personality and adjustment. Research in the use of leisure. The trend toward intellectual and expressive sophistication in free-time activity on the part of educators to what happens to the young people they educate. KW - Aging KW - Personality & emotions KW - Perception KW - Leisure KW - Attitude (Psychology) KW - Personality N1 - Accession Number: 18812152; Authors: Birren, James F. 1; Jerome, Edward A. 1; Chown, Sheila M. 2; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland; 2: Bedford College, London, England; Subject: Aging; Subject: Personality & emotions; Subject: Perception; Subject: Leisure; Subject: Attitude (Psychology); Subject: Personality; Number of Pages: 13p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=18812152&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - JOUR ID - 2006-06018-017 AN - 2006-06018-017 AU - Mishkin, Mortimer T1 - Blind Spots in Visual Theory. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1961/12// VL - 6 IS - 12 SP - 446 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06018-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Mishkin, Mortimer; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Blind; Brain; Visual Field; Wounds. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10). Reviewed Item: Teuber, Hans-Lukas; Battersby, William S.; Bender, Morris B. Visual Field Defects after Penetrating Missile Wounds of the Brain=Cambridge, Mass.: Harvard University Press, for the Commonwealth Fund, 1960. Pp. xii + 143. $4.75; 1960. Page Count: 2. Issue Publication Date: Dec, 1961. AB - Reviews the book, Visual Field Defects after Penetrating Missile Wounds of the Brain by Hans-Lukas Teuber, William S. Battersby, and Morris B. Bender (see record [rid]1960-35059-000[/rid]). The presentation, 'half text, half pictures,' moves steadily along from the least to the most questionable aspects of the localizationist doctrine. The one offered by Teuber, Battersby, and Bender is not designed to please localizationists. The authors suggest that the smaller defect for the contralateral eye is due to the low vulnerability of its large crossed projection. There is ample evidence showing that severe visual deficits, apparently unrelated to particular retinal loci, may be produced by nonstriate lesions in animals, and the probability is high that any missile wound in man which damages the primary visual system would damage these secondary visual areas as well. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - visual theory KW - blind spots KW - visual field defects KW - missile wounds KW - brain KW - 1961 KW - Blind KW - Brain KW - Visual Field KW - Wounds KW - 1961 U2 - Teuber, Hans-Lukas; Battersby, William S.; Bender, Morris B. (1960); Visual Field Defects after Penetrating Missile Wounds of the Brain; Cambridge, Mass.: Harvard University Press, for the Commonwealth Fund, 1960. Pp. xii + 143. $4.75 DO - 10.1037/006497 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06018-017&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-001 AN - 2008-13023-001 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Introduction. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 1 EP - 19 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-001. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Human Development; Introspection; Longitudinal Studies; Personality Development; Psychotherapy. Minor Descriptor: Interdisciplinary Treatment Approach; Life Experiences. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 19. AB - Many of the behaviors that characterize childhood have transient lives and are either replaced or dropped long before maturity. Egocentric speech, faulty articulation, and fear of the dark are each associated with specific developmental periods, and we are not surprised when they vanish from the behavioral scene. There has always been, however, an explicit and rather dogmatic conviction that selected adult motives, attitudes, and behaviors begin their growth during the first 10 years of life. Once established during the childhood years, these responses are likely to remain permanent aspects of the individual's behavioral repertoire. Retrospective impressions of childhood gathered from psychotherapy sessions, anecdotal reports, and private introspections support this belief, but more substantial evidence has been difficult to obtain. Only systematic longitudinal observations can discover those behaviors that are marked for future use and those that will be lost along the way. This book summarizes an investigation of the personality development of 89 white children (45 females and 44 males) from the Fels Research Institute's longitudinal population. These children, with their parents, have been participants in a longitudinal study of their psychological development from birth through early adulthood. The initiation of this project was coincident with the birth of the Institute and its multidisciplinary study of human development. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - longitudinal observations KW - personality development KW - retrospective impressions KW - human development KW - psychotherapy sessions KW - introspections KW - multidisciplinary study KW - 1962 KW - Human Development KW - Introspection KW - Longitudinal Studies KW - Personality Development KW - Psychotherapy KW - Interdisciplinary Treatment Approach KW - Life Experiences KW - 1962 DO - 10.1037/13129-001 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-002 AN - 2008-13023-002 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Methods of assessment. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 20 EP - 48 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-002. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Data Collection; Human Development; Longitudinal Studies; Measurement; Methodology. Minor Descriptor: Behavior; Developmental Age Groups; Intelligence Measures; Interviews; Narratives; Observation Methods; Projective Personality Measures; Rating. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Modified Rorschach; Murray (1943) Thematic Apperception Test; Shneidman Make-A-Picture-Story Test (1949); French Insight Test (French 1955; French 1956); Tachistoscopic recognition task; Hanfmann-Kasanin Concept Formation test; Parent Behavior Rating Scale; Child Behavior Rating Scale DOI: 10.1037/t14094-000; Wechsler-Bellevue Intelligence Scale--Form I DOI: 10.1037/t06871-000. Methodology: Empirical Study; Longitudinal Study. Page Count: 29. AB - This chapter describes the methods and sources of data associated with the longitudinal and adult assessments. The longitudinal program will be considered first. The longitudinal material was collected during the years 1929 to 1954. The first few years of data collection were unsystematic, but by 1933 a fairly comprehensive program had taken form, and the program that was established in the 1930's has remained the basic model for data collection up to the present time. The longitudinal data that were used to make the childhood ratings included two major classes of information: (1) narrative reports and ratings of behavior observations and (2) interview protocols and interview summaries. The intelligence and projective test protocols were analyzed independently and did not enter into these ratings. All of these protocols were gathered according to the schedule outlined in Table 3 of Chapter One. The intelligence and personality tests were administered through the use of procedures recommended in their respective manuals. The narrative reports and interview summaries were necessarily subjective and influenced by several uncontrolled factors. Since these reports were the basis of the behavioral ratings covering the first 14 years of life, a description of this material should provide the reader with a base on which to judge the results. The observations were based on visits to the home, visits to the public school, and the child's behavior in the Fels Nursery School and Day Camp. The interview summaries were based on discussions with the child, mother, and the child's teacher. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - longitudinal data KW - assessment KW - data collection KW - intelligence test protocols KW - projective tests KW - narrative reports KW - interview summaries KW - behavioral ratings KW - home visits KW - observations KW - interviews KW - 1962 KW - Data Collection KW - Human Development KW - Longitudinal Studies KW - Measurement KW - Methodology KW - Behavior KW - Developmental Age Groups KW - Intelligence Measures KW - Interviews KW - Narratives KW - Observation Methods KW - Projective Personality Measures KW - Rating KW - 1962 DO - 10.1037/13129-002 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-003 AN - 2008-13023-003 AU - Kagan, Jerome AU - Moss, Howard A. T1 - The stability of behavior: I. Passivity and dependency. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 49 EP - 84 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-003. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Dependency (Personality); Human Development; Longitudinal Studies; Measurement; Passiveness. Minor Descriptor: Biology; Data Collection; Predisposition. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 36. AB - The next four chapters describe the pattern of developmental continuity for a group of behaviors that were assessed during both childhood and adulthood. The areas are passivity, dependency, aggression, competitiveness, achievement, recognition, heterosexuality, sex-role identification, social interaction, fear of physical harm, nurturance, compulsivity, and hyperkinesis. This chapter focuses on passive and dependent behavior. Although the data from the present study and those of other investigations must be regarded as highly tentative, they suggest two hypotheses that merit attention: (1) a predisposition to passivity is a function, in part, of biological variables and (2) the foundation for extreme degrees of passivity, or its derivatives, in late childhood, adolescence and adulthood are established during the first six years of life. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - developmental continuity KW - childhood behaviors KW - assessment KW - passivity KW - dependency KW - human development KW - predisposition KW - biological variables KW - 1962 KW - Dependency (Personality) KW - Human Development KW - Longitudinal Studies KW - Measurement KW - Passiveness KW - Biology KW - Data Collection KW - Predisposition KW - 1962 DO - 10.1037/13129-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-004 AN - 2008-13023-004 AU - Kagan, Jerome AU - Moss, Howard A. T1 - The stability of behavior: II. Aggression. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 85 EP - 119 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-004. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Aggressive Behavior; Childhood Development; Conflict; Developmental Age Groups; Emotional Development. Minor Descriptor: Anger; Emotional Immaturity; Emotions; Family Relations; Human Sex Differences; Injuries; Peer Relations; Rewards; Socialization. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 35. AB - Aggression is a second behavior system that begins its growth during the first five years. Traditionally a response was labeled aggressive if the goal of the behavior was assumed to be psychological or physical injury to a person or person surrogate. We have adhered to this definition. As with dependency, the display of aggressive acts is a regular concomitant of development. The slapping or pushing of an age mate, the destruction of a sibling's new fort, and the stinging verbal attack are regularly observed in the behavior of many children. Aggression, like dependency, is subject to socialization pressures, for the child does not have complete license to unleash his anger when he chooses. In addition, as with dependency, the occurrence of overt aggression is a function of both the threshold for motive arousal and the intensity of anxiety associated with direct expression of this behavior. In contrast to dependency, however, the potential for conflict over aggression is greater for females than for males. The pattern of social rewards and traditional sex-role standards act in concert to discourage the direct expression of aggression in girls and women. It might be anticipated, therefore, that aspects of aggression would be more stable for males than for females. This is precisely what occurred, for overt aggression to mother and frequent tantrums during childhood predicted adult aggressivity for men but not for women. This chapter contains a detailed description of the pattern of stability for different aggressive behaviors. The format follows that of the previous chapter. A cluster of seven aggressive variables was rated for part or all of the four childhood periods, and abridged definitions of these variables follow. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - aggression KW - aggressive response KW - injury as goal KW - attacks KW - injurious behavior KW - development KW - children's behavior KW - males KW - females KW - stability pattern KW - aggressive variables KW - 1962 KW - Aggressive Behavior KW - Childhood Development KW - Conflict KW - Developmental Age Groups KW - Emotional Development KW - Anger KW - Emotional Immaturity KW - Emotions KW - Family Relations KW - Human Sex Differences KW - Injuries KW - Peer Relations KW - Rewards KW - Socialization KW - 1962 DO - 10.1037/13129-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-005 AN - 2008-13023-005 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Stability of behavior: III. Achievement and recognition. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 120 EP - 155 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-005. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Ability Level; Achievement; Competence; Self-Concept; Social Approval. Minor Descriptor: Expectations; Goals; Human Sex Differences; Praise; Responses; Rewards; Social Acceptance. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 36. AB - Achievement and recognition behaviors are socially valued responses for both boys and girls. It might be anticipated that the stability of achievement and recognition behavior would be generally high for both males and females, in contrast to the pattern found for the previous two response clusters. This expectation was verified in the data to be presented. Achievement and recognition are considered together because the overt behaviors that gratify these motives overlap to a large degree. Achievement is defined as behavior aimed at satisfaction of an internal standard of excellence. The goal of achievement behavior is self-approval for performing tasks at a level of competence that an individual had previously established as satisfying. In recognition behavior, the goal is some positive reaction from other people--a social acknowledgment of the individual's skills. For the present sample, the areas of competence that were most highly prized were intellectual, athletic, mechanical, and artistic abilities. Although competence in these areas brought feelings of self-satisfaction, acquisition of these skills also resulted in social recognition. Family, peers, and teachers awarded praise and prizes for academic, athletic, or artistic achievements. Hence it is extremely difficult to differentiate achievement and recognition motives. Involvement in school work or long hours of baseball practice can indicate strong achievement or recognition motives, or both. The data reveal a high, positive correlation between these two variables. This could mean either that our methods were not sufficiently sensitive to separate these two motives or that it is impossible to measure the desire to improve at a skill, independent of the person's desire for social recognition for this improvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - achievement behaviors KW - social recognition KW - goals KW - behavioral stability KW - self approval KW - response clusters KW - internal standard of excellence KW - positive reaction KW - social acknowledgment KW - competence KW - 1962 KW - Ability Level KW - Achievement KW - Competence KW - Self-Concept KW - Social Approval KW - Expectations KW - Goals KW - Human Sex Differences KW - Praise KW - Responses KW - Rewards KW - Social Acceptance KW - 1962 DO - 10.1037/13129-005 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-006 AN - 2008-13023-006 AU - Kagan, Jerome AU - Moss, Howard A. T1 - The stability of behavior: IV. Sexuality, social interaction, and selected behaviors. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 156 EP - 203 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-006. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Heterosexuality; Human Development; Rating; Sex Role Attitudes; Social Interaction. Minor Descriptor: Age Differences; Anxiety; Compulsions; Developmental Age Groups; Fear; Hyperkinesis; Introspection; Longitudinal Studies; Sexuality. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 48. AB - This chapter will consider the stability of heterosexual behavior, traditional sex-role interests, social-interaction anxiety, compulsivity, nurturance, fear of bodily harm, hyperkinesis, and introspectiveness. Some of the variables were only rated for one or two of the longitudinal periods; others for all four age periods. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - compulsivity KW - stability ratings KW - heterosexual behavior KW - sex-role interests KW - social-interaction KW - anxiety KW - nurturance KW - fear of bodily harm KW - introspectiveness KW - longitudinal periods KW - age periods KW - 1962 KW - Heterosexuality KW - Human Development KW - Rating KW - Sex Role Attitudes KW - Social Interaction KW - Age Differences KW - Anxiety KW - Compulsions KW - Developmental Age Groups KW - Fear KW - Hyperkinesis KW - Introspection KW - Longitudinal Studies KW - Sexuality KW - 1962 DO - 10.1037/13129-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-007 AN - 2008-13023-007 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Maternal practices and the child's behavior. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 204 EP - 228 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-007. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Childhood Development; Childrearing Practices; Mother Child Relations; Mothers. Minor Descriptor: Criticism; Dependency (Personality); Hostility; Passiveness. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 25. AB - The acquisition and continued practice of a given response are determined by a variety of familial and extra-familial experiences. The nature of the longitudinal data and the existing theoretical climate directed our attention to the influence of one class of antecedent events on the child's developing personality: maternal treatment of the child. Theory and research have acknowledged the profound importance of the mother as a determinant of the child's behavior. As part of the Fels program, observations and interviews with the mothers of our children occurred during the first 12 to 14 years. The sources of these data were described in Chapter Two and consisted primarily of home visits and interviews. From these protocols, four types of maternal practices were evaluated: (a) maternal protection, (b) maternal restrictiveness, (c) maternal hostility and criticism, and (d) maternal acceleration of the child's developmental progress. These variables were defined and rated on a seven-point scale. Despite some suggestive trends, the four maternal behaviors were not highly predictive of adult dependency, especially for men, and were poorer predictors of adult passive or dependent behavior than the child's own behavior during age 6 to 10 or 10 to 14. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - maternal treatment KW - children KW - child behavior KW - mothers KW - maternal protection KW - restrictiveness KW - hostility KW - criticism KW - interviews KW - developmental progress KW - dependency KW - 1962 KW - Childhood Development KW - Childrearing Practices KW - Mother Child Relations KW - Mothers KW - Criticism KW - Dependency (Personality) KW - Hostility KW - Passiveness KW - 1962 DO - 10.1037/13129-007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-008 AN - 2008-13023-008 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Sources of conflict and anxiety. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 229 EP - 265 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-008. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Anxiety; Conflict; Measurement; Tachistoscopic Presentation. Minor Descriptor: Test Validity. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 37. AB - We turned to two popular and objective methods of assessing anxiety and conflict. In the tachistoscopic situation, distortion or delayed recognition of conflictful scenes was presumed to be a consequent of anxiety in the area illustrated. It was assumed that if a specific content were anxiety arousing, ideational representations of this content would be more likely to be repressed and, therefore, less readily available for a correct perceptual hypothesis. That is, the strength of the perceptual hypothesis, 'That is a man choking a man,' should be weaker for adults highly conflicted over aggression than for those with low conflict. The order of recall of these scenes (90 minutes later) was used as a supplementary index of conflict (i.e., decreased availability of the anxiety-arousing ideas). A second potential index of conflict-produced anxiety was a change in either heart rate or palmar conductance in response to an anxiety-arousing communication. Since anxiety is a state of affective arousal, it seems reasonable to conclude that the intensity of anxiety elicited by a stimulus should be reflected in a proportional amount of discharge in autonomic target organs. Five sources of anxiety were studied: conflict over dependency, aggression, and sexual behavior, as well as anxiety over bodily harm and intellectual competence. The tachistoscopic task sampled the areas of dependency, aggression, sexuality, and bodily harm; the autonomic battery sampled anxiety over aggression, sexuality, bodily harm, and intellectual competence. The assumption that delayed recognition of conflictful scenes or autonomic discharge to conflictful communications reflects anxiety is of questionable validity. Many investigators are attempting to prove or disprove these hypotheses. The data to be reported, therefore, bear directly on this important methodological problem: the validity of tachistoscopic perception or autonomic discharge as indexes of anxiety associated with behavior and goal states that are regarded as conflictful in this society. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - anxiety KW - conflict scenes KW - measurement KW - tachistoscopic perception KW - autonomic discharge KW - 1962 KW - Anxiety KW - Conflict KW - Measurement KW - Tachistoscopic Presentation KW - Test Validity KW - 1962 DO - 10.1037/13129-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2008-13023-009 AN - 2008-13023-009 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Summary and conclusions. T2 - Birth to maturity: A study in psychological development. Y1 - 1962/// SP - 266 EP - 286 CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-009. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior; Dependency (Personality); Human Development; Passiveness; Sex Role Attitudes. Minor Descriptor: Anger; Anxiety; Emotional Adjustment; Longitudinal Studies; Personality Development; Sex Roles; Stress. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. Page Count: 21. AB - In this summary chapter, the authors present five conclusions that are relevant for developmental theory or for current methodological issues. The following topics are discussed: (1) differential stability of behavior as a function of sex typing; (2) sex differences in patterns of relationships; (3) the significance of early passivity; (4) the sleeper effect; and (5) conceptual style, autonomic reactivity and the measurement of conflict. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - childhood behaviors KW - childhood development KW - sex differences KW - sex typing KW - passivity KW - conceptual style KW - autonomic reactivity KW - measurement KW - conflict KW - dependency KW - 1962 KW - Behavior KW - Dependency (Personality) KW - Human Development KW - Passiveness KW - Sex Role Attitudes KW - Anger KW - Anxiety KW - Emotional Adjustment KW - Longitudinal Studies KW - Personality Development KW - Sex Roles KW - Stress KW - 1962 DO - 10.1037/13129-009 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2004-19281-013 AN - 2004-19281-013 AU - Shakow, David ED - Strupp, Hans H. ED - Luborsky, Lester ED - Strupp, Hans H., (Ed) ED - Luborsky, Lester, (Ed) T1 - Discussion of Papers Relating to Definition of Variables. T2 - Research in psychotherapy. Y1 - 1962/// SP - 237 EP - 241 CY - Washington, DC, US PB - American Psychological Association N1 - Accession Number: 2004-19281-013. Partial author list: First Author & Affiliation: Shakow, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20041025. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Comment/Reply. Language: English. Conference Information: Second Conference on Research in Psychotherapy, May, 1961, Chapel Hill, NC, US. Major Descriptor: Experimentation; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 5. AB - Comments on papers by J. M. Butler et al (see record [rid]2004-19281-010[/rid]), R. S. Siegal and I. C. Rosen 200419281-011), and H. L. Lennard 200419281-012) about research problems relating to the definition of variables in psychotherapy. In relation to the Butler et al paper, D. Shakow raises several questions about the place and limits of the naturalistic approach in the study of the psychotherapy situation. In the case of Lennard, Shakow considers particularly the problem of deutero-learning and its relationship to the kinds of learning which take place in psychotherapy. And with respect to Siegal and Rosen's paper, Shakow examines further the use of inference in the psychodiagnostic situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychotherapy KW - research problems KW - definition of variables KW - 1962 KW - Experimentation KW - Psychotherapy KW - 1962 DO - 10.1037/10591-013 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19281-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2004-19281-014 AN - 2004-19281-014 AU - Parloff, Morris B. ED - Strupp, Hans H. ED - Luborsky, Lester ED - Strupp, Hans H., (Ed) ED - Luborsky, Lester, (Ed) T1 - Summary Report: Therapist's Contribution (A). T2 - Research in psychotherapy. Y1 - 1962/// SP - 256 EP - 258 CY - Washington, DC, US PB - American Psychological Association N1 - Accession Number: 2004-19281-014. Partial author list: First Author & Affiliation: Parloff, Morris B.; Section on Personality, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20041025. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Second Conference on Research in Psychotherapy, May, 1961, Chapel Hill, NC, US. Major Descriptor: Experimentation; Psychotherapeutic Processes; Psychotherapists; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 3. AB - Presents a summary report of a panel discussion on research problems relating to the psychotherapist's contribution to the treatment process. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychotherapist's contribution to treatment process KW - research problems KW - 1962 KW - Experimentation KW - Psychotherapeutic Processes KW - Psychotherapists KW - Psychotherapy KW - 1962 DO - 10.1037/10591-014 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19281-014&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - BOOK ID - 2008-13023-000 AN - 2008-13023-000 AU - Kagan, Jerome AU - Moss, Howard A. T1 - Birth to maturity: A study in psychological development. Y1 - 1962/// CY - Hoboken, NJ, US PB - John Wiley & Sons Inc N1 - Accession Number: 2008-13023-000. Partial author list: First Author & Affiliation: Kagan, Jerome; Fels Research Institute, Yellow Springs, OH, US. Release Date: 20080922. Correction Date: 20120910. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Developmental Age Groups; Human Development; Longitudinal Studies; Measurement; Personality Measures. Minor Descriptor: Age Differences; Psychoanalysis; Psychoanalytic Theory; Testing. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 381. AB - This book is a summary of a comprehensive assessment of a group of young adults who have been members of the Fels Research Institute's longitudinal population since their birth. The potential contributions of this longitudinal investigation fall into four categories. The findings of this study point to islands of continuity amidst the changing response patterns of the growing child and suggest that some popular hypotheses about development need revision. This investigation uncovered several new and provocative ideas about developmental sequences that are not emphasized by current theorists and that deserve careful empirical attention. Finally, we attempted to test the validity of some contemporary personality assessment techniques by studying the relations between the test protocols produced by our subjects and the rich and extensive behavioral information available on each of them. There is one set of issues that this book does not presume to evaluate. The gathering of the early longitudinal data was not guided by a consistent theoretical orientation, and it is impossible, therefore, to comment on the validity of psychoanalytic or behavioral theory as they refer to cause-effect sequences in development. Correlatively, this book does not contain any elaborate theoretical integration of psychological development. We would have liked to assume this responsibility but the data prohibited such an ambitious undertaking. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - comprehensive assessment KW - young adults KW - development KW - longitudinal population KW - developmental sequences KW - personality assessment techniques KW - test protocols KW - behavioral information KW - psychoanalytic theory KW - 1962 KW - Developmental Age Groups KW - Human Development KW - Longitudinal Studies KW - Measurement KW - Personality Measures KW - Age Differences KW - Psychoanalysis KW - Psychoanalytic Theory KW - Testing KW - 1962 DO - 10.1037/13129-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13023-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Pearlin, Leonard I. T1 - ALIENATION FROM WORK: A STUDY OF NURSING PERSONNEL. JO - American Sociological Review JF - American Sociological Review Y1 - 1962/06// VL - 27 IS - 3 M3 - Article SP - 314 EP - 326 SN - 00031224 AB - Alienation, defined as subjectively experienced powerlessness to control one's own work activities, is examined among the nursing force of a large mental hospital. It is found that alienation is intensified where authority relations are such as to limit the reciprocal influence of subordinates. This is reflected in situations where there is great positional disparity between superordinates and their subjects, where authority is exercised in a peremptory fashion and where authority figures are physically inaccessible. Career experiences within the hospital opportunity structure are also related to alienation; limited achievement and dissatisfaction with extrinsic work rewards are alienative conditions. Finally, personnel working in isolation and without outside social ties to fellow workers are more subject to intense alienation. [ABSTRACT FROM AUTHOR] AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - HOSPITAL personnel KW - MEDICAL care KW - PSYCHIATRIC hospitals KW - EMPLOYEES KW - AUTHORITY KW - ALIENATION (Social psychology) N1 - Accession Number: 12766591; Pearlin, Leonard I. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Jun62, Vol. 27 Issue 3, p314; Thesaurus Term: HOSPITAL personnel; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHIATRIC hospitals; Thesaurus Term: EMPLOYEES; Thesaurus Term: AUTHORITY; Subject Term: ALIENATION (Social psychology); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; Number of Pages: 13p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12766591&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Rosenberg, Morris T1 - SELF-ESTEEM AND CONCERN WITH PUBLIC AFFAIRS. JO - Public Opinion Quarterly JF - Public Opinion Quarterly Y1 - 1962///Summer62 VL - 26 IS - 2 M3 - Article SP - 201 EP - 211 SN - 0033362X AB - The problem of self-esteem is a very different one when seen from the viewpoint of the individual than when considered from the perspective of society. From the viewpoint of the individual, fundamental self-hatred is a tragedy of no mean proportions, compounded of depression, tension, and anxiety, and in various ways warping the lives of those afflicted with it. From the viewpoint of society, it has clear implications for the operation of a democratic system of society. For if democracy provides a mechanism by which citizens can have their wills translated into political policy, then it becomes farcical to speak of democracy if it is broadly based upon an ignorant, uninterested, and uninfluential electorate. Hence, the family and other social conditions which operate to destroy the child's sense of worth are at the same time undermining the personality prerequisites of a democratic society. The main reassurance lies in the fact that, at least according to the data, so many more adolescents appear to be characterized by a fundamental feeling of self-acceptance than seem to be afflicted with feelings of self-rejection. KW - Self-esteem KW - Political science KW - Self-acceptance KW - Anxiety KW - Emotions (Psychology) KW - Democracy KW - Social history N1 - Accession Number: 11956487; Rosenberg, Morris 1; Affiliations: 1: Social Science Analyst, Laboratory of Socio-environmental Studies, National Institute of Mental Health.; Issue Info: Summer62, Vol. 26 Issue 2, p201; Thesaurus Term: Self-esteem; Thesaurus Term: Political science; Subject Term: Self-acceptance; Subject Term: Anxiety; Subject Term: Emotions (Psychology); Subject Term: Democracy; Subject Term: Social history; Number of Pages: 11p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11956487&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - JOUR T1 - AN OTHER-DIRECTED FANTASY IN A PUERTO RICAN. AU - Field, P. B. AU - Maldonado-Sierra, E. D. AU - Wallace, S. E. AU - Bodarky, C. J. AU - Coelho, G. V. JO - Journal of Social Psychology JF - Journal of Social Psychology Y1 - 1962/10// VL - 58 IS - 1 SP - 43 EP - 60 SN - 00224545 N1 - Accession Number: 16487527; Author: Field, P. B.: 1 Author: Maldonado-Sierra, E. D.: 1 Author: Wallace, S. E.: 1 Author: Bodarky, C. J.: 1 Author: Coelho, G. V.: 1 ; Author Affiliation: 1 Puerto Rico Institute of Psychiatry and National Institute of Mental Health.; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20050323 N2 - A TAT story in which the hero decided to adjust himself to a peer group's wishes is the starting point of a case study of the personal relationships of a Puerto Rican college student. The student is one of 20 studied in an attempt to extend cross-culturally a research program on students who showed superiority in the social, academic, and extracurricular spheres. We related our analysis of this student to various cultural themes in Puerto Rico--including the familism, the exaggerated masculine role prescribed for males, and the preferential treatment given the oldest son in the family. While we emphasized the multiple determination of this student's other-directed peer-group dependency, we concluded that one major determining factor in his dependency is an unrewarding, distant relationship to his family, leading to a search for compensating personal relationships with other social groups. This student's unsatisfying formal, hierarchical, and impersonal family relationships lead him to seek instead the informal, personal, loosely-organized relationships of a peer group. He tries to achieve success through dependency, conformity, obedience, and conciliation rather than through independent self-assertion; previous authors have reported that many Puerto Ricans tend to share some of these traits. ABSTRACT FROM AUTHOR KW - *COLLEGE students KW - *GROUP decision making KW - AGE groups KW - INTERPERSONAL relations KW - SOCIAL groups KW - PUERTO Rico UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=16487527&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR AU - Rosenberg, Morris AU - Pearlin, Leonard I. T1 - Power-Orientations in the Mental Hospital. JO - Human Relations JF - Human Relations Y1 - 1962/11// VL - 15 IS - 4 M3 - Article SP - 335 EP - 349 SN - 00187267 AB - The article provides information on the research conducted to determine if mental hospital nurses exercise their power when face with difficult situation. According to the author, the aim of the study is to evaluate how mental hospital staff tend to implement to control the situation and to examine the criteria that they use when a situation require. He adds that exercise and implementation of power is required especially in the area of life involving human interaction and association to control, motivate and influence the behavior of patients and projects authoritative personality. Questionnaires, intensive interviews were used to collect data and personal experience accounts of the respondents were presented. KW - MENTAL health personnel KW - MEDICAL care KW - PSYCHIATRIC hospitals KW - MENTAL health facilities KW - QUESTIONNAIRES KW - RESEARCH KW - PSYCHIATRIC nurses KW - PATIENTS KW - MENTALLY ill -- Care N1 - Accession Number: 24585976; Rosenberg, Morris 1; Pearlin, Leonard I.; Affiliations: 1: Social Science Analyst, Laboratory of Social-Environmental Studies, National Institute of Mental Health; Issue Info: Nov62, Vol. 15 Issue 4, p335; Thesaurus Term: MENTAL health personnel; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHIATRIC hospitals; Thesaurus Term: MENTAL health facilities; Thesaurus Term: QUESTIONNAIRES; Thesaurus Term: RESEARCH; Subject Term: PSYCHIATRIC nurses; Subject Term: PATIENTS; Subject Term: MENTALLY ill -- Care; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621112 Offices of Physicians, Mental Health Specialists; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; Number of Pages: 15p; Illustrations: 4 Charts; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=24585976&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-06029-015 AN - 2006-06029-015 AU - Coelho, George V. T1 - un-American Social Psychology. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1962/11// VL - 7 IS - 11 SP - 420 EP - 421 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06029-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Coelho, George V.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Culture (Anthropological); Mind; Social Psychology; Society. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Akolkar, V. V. Social Psychology: A Study of Mind in Society=London: Asia Publishing House (U. S. Distr. Taplinger Publishing Co., Inc.) 4th edition, 1960. Pp. 307. $4.50; 1960. Page Count: 2. Issue Publication Date: Nov, 1962. AB - Reviews the book, Social Psychology: A Study of Mind in Society by V. V. Akolkar (1960). Persistent issues in social psychology usually include group mind theories, the nature of social learning, the development of social motives, the articulation of individual personality with social systems, and the influence of culture patterns on social perception and interaction. Professor Akolkar deals lucidly with these broad theoretical issues in the first half of his book, using scholarly detail in historical perspective that is often lost to the present-day student. Neglectful of significant modern sources, Professor Akolkar nevertheless shows sound judgment and imagination in examining older authorities. He criticizes McDougall--whose Social Psychology (1908) was the first book to be published with that title--for his theories of instinct and national character. The chapter on Personality nicely divides the book into two major sections. Professor Akolkar suggests that the evolution of religious consciousness, like that of moral consciousness, is marked by an increasing refinement in man's view of, and relationship with the Unseen. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - American social psychology KW - mind KW - society KW - individual personality KW - culture patterns KW - 1962 KW - Culture (Anthropological) KW - Mind KW - Social Psychology KW - Society KW - 1962 U2 - Akolkar, V. V. (1960); Social Psychology: A Study of Mind in Society; London: Asia Publishing House (U. S. Distr. Taplinger Publishing Co., Inc.) 4th edition, 1960. Pp. 307. $4.50 DO - 10.1037/006775 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06029-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - D'Arnonlo, William V. AU - Ehrlich, Howard J. AU - Erickson, Eugene C. T1 - FURTHER NOTES ON THE STUDY OF COMMUNITY POWER. JO - American Sociological Review JF - American Sociological Review Y1 - 1962/12// VL - 27 IS - 6 M3 - Article SP - 848 EP - 854 SN - 00031224 AB - The exchanges with Raymond E. Wolfinger and Nelson W. Polsby perform, perhaps, a necessary function in keeping everyone alert to the problems and ambiguities of the studies. This is, at least, better than having such difficulties "resolved" by passive consent and "tradition." It is regretted that, in this exchange, the editorial deadline did not permit a more detailed exploration of the related and clearly important unresolved issues of community power research and theory. The phenomenon of continual innovation in methodology, coupled with the fact that most research known today employs elements of both "reputational" and "decision-making" techniques, serves only to heighten the concern with methodology. While the deficiencies of reputational techniques have received considerable attention and currency, the issues or decision-making approach has received little in the way of critical scrutiny. Certainly, such matters as defining community issues, the salience of issues, and the sampling of issues have received relatively little attention. KW - DECISION making KW - RESEARCH KW - COMMUNITY power KW - METHODOLOGY KW - WOLFINGER, Raymond E., 1931-2015 KW - POLSBY, Nelson W. N1 - Accession Number: 12788907; D'Arnonlo, William V. 1; Ehrlich, Howard J. 2; Erickson, Eugene C. 3; Affiliations: 1: University of Notre Dame; 2: National institute of Mental Health; 3: Washington State University; Issue Info: Dec62, Vol. 27 Issue 6, p848; Thesaurus Term: DECISION making; Thesaurus Term: RESEARCH; Subject Term: COMMUNITY power; Subject Term: METHODOLOGY; People: WOLFINGER, Raymond E., 1931-2015; People: POLSBY, Nelson W.; Number of Pages: 7p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12788907&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - Gen ID - 9999-14266-000 AN - 9999-14266-000 AU - Katz, Martin M. AU - Lyerly, Samuel B. T1 - Katz Adjustment Scale--Form R2 JF - PsycTESTS JO - PsycTESTS Y1 - 1963/// AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No N1 - Accession Number: 9999-14266-000. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20120910. Language: English. Constructs: Adjustment; Population: Human (10). N2 - Administration Method: Paper AB - Purpose: The purpose of the Katz Adjustment Scale--Form R2 is to assess adjustment. AB - Description: The Katz Adjustment Scale--Form R2 (Katz & Lyerly, 1963) inventory consists of a list of 16 activities which include items describing family and social responsibilities, social activites, self-care, home adjustment, and community activities. The list is a modification of one prepared by Freeman and Simmons (1958). The relative indicates for a given activity whether the patient 'is not doing it,' 'is doing it some,' or 'is doing it regularly.' The items are rated on a three-point scale and summed for a total score. The score is viewed simply as a measure of the level or amount of socially expected activities in which the patient has been involved during the several weeks preceding the relative's report. KW - Katz Adjustment Scale--Form R2 KW - Test Development KW - Social Behavior KW - Community Readjustment KW - Discriminative Validity KW - Rationale KW - Description U5 - Katz Adjustment Scale--Form R2 [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Population: Human; Sample: Hospital Patients Readjusting to the Community; Location: United States Keywords: Katz Adjustment Scale--Form R2; Test Development; Social Behavior; Community Readjustment; Discriminative Validity; Rationale; Description; Subjects: Psychosocial Readjustment; Rating Scales; Social Adjustment; Social Behavior; Test Construction; Test Forms; Test Validity; DO - 10.1037/t14266-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14266-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - Gen ID - 9999-14270-000 AN - 9999-14270-000 AU - Katz, Martin M. AU - Lyerly, Samuel B. T1 - Katz Adjustment Scale--Form R4 JF - PsycTESTS JO - PsycTESTS Y1 - 1963/// AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No N1 - Accession Number: 9999-14270-000. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20120910. Language: English. Constructs: Adjustment; Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). N2 - Administration Method: Paper AB - Purpose: The purpose of the Katz Adjustment Scale--Form R4 is to objectively assess the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community. AB - Description: The Katz Adjustment Scale--Form R4 (Katz & Lyerly, 1963) is an inventory for objectively assessing the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community. The major characteristics of the scales are their reliance on both the patient and a relative in measuring social behavior, the use of a relative as a direct reporter, and the establishment of his reliability in describing patient behavior. The scales have been designed for application to the problems of describing and classifying patients in accordance with their behavior prior to entrance to the hospital and in the community follow-up evaluation and comparison of psychiatric treatments. In a comparison of well- and poorly- adjusted groups of patients, the scales are demonstrated to be highly discriminative and capable of closely approximating expert clinical judgment. KW - Factor Analysis KW - Katz Adjustment Scale--Form R4 KW - Psychoticism KW - Test Development KW - Psychometric Properties U5 - Katz Adjustment Scale--Form R4 [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Location: United States; Sample: Psychiatric Patients Keywords: Factor Analysis; Katz Adjustment Scale--Form R4; Psychoticism; Test Development; Psychometric Properties; Subjects: Factor Analysis; Psychoticism; Test Construction; Test Reliability; Test Validity; DO - 10.1037/t14270-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14270-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - Gen ID - 9999-04041-000 AN - 9999-04041-000 AU - Katz, Martin M. AU - Lyerly, Samuel B. T1 - Katz Adjustment Scales JF - PsycTESTS JO - PsycTESTS Y1 - 1963/// AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No N1 - Accession Number: 9999-04041-000. Acronyms: KAS. Partial author list: First Author & Affiliation: Katz, Martin M.; National Institute of Mental Health, Psychopharmacology Service Center, United States. Release Date: 20130107. Instrument Type: Rating Scale. Test Format: Items in both sets of inventories are rated on 3- and 4-point scales.. Language: English. Constructs: Functional Ability; Classification: Functional Status and Adaptive Behavior (6200). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). N2 - Administration Method: Paper AB - Purpose: The Katz Adjustment Scales are designed to assess different aspects of the patient's functioning in the community from two points of view, a close relative's and the patient's. AB - Description: The Katz Adjustment Scales (KAS; Katz & Lyerly, 1963) is a set of inventories for objectively assessing the adjustment and social behavior of pre-psychotic and ex-hospital patients in the community. The major characteristics of the scales are their reliance on both the patient and a relative in measuring social behavior, the use of a relative as a direct reporter, and the establishment of his reliability in describing patient behavior. The scales have been designed for application to the problems of describing and classifying patients in accordance with their behavior prior to entrance to the hospital and in the community follow-up evaluation and comparison of psychiatric treatments. The 127-item Form R1 (Relative's Ratings of Patient Symptoms and Social Behavior) was designed to provide a record of the patient's symptomatology and social behavior during a period of several weeks prior to the relative's report. Form R2 (Level of Performance of Socially-Expected Activities) consists of a list of 16 activities which include items describing family and social responsibilities, social activites, self-care, home adjustment, and community activities. Items in Form R3 (Level of Expectations) are identical to those in Form R2; however, the relative is asked to indicate for a given activity whether he had or had not expected the patient to be doing this within a reasonable time following his return to the home. Form RS4 (Level of Free-Time Activities) is modeled after the Activities and Attitudes Scales (Cavan, et al., 1949); the 23 items cover hobbies, social and community activities, and self-improvement activicies. The items in Form R5 (Level of Satisfaction with Free-Time Activities) are identical to those in Form RS4; the relative is asked for a given activity, whether he is satisfied with what the patient is doing in this area, or whether he would like to see him do more or do less of this activity. The 55-item Form S1 (Symptom Discomfort) measures patient discomfort in the symptom area; items were slightly modified from the Johns Hopkins Symptom Distress Checklist described by Parloff et al (1954). Form S2 (Level of Performance of Socially-Expected Activities), Form S9 (Level of Expectations), Form RS4 (Level of Free-Time Activities, and Form SS (Level of Satisfaction with Free-Time Activities are adapted for self-ratings but are otherwise identical to those designed for the relatives (Forms Forms R2, R3, RS4, and R5). In a cross-validation sample, the measures are found to have reasonably high internal consistency and to demonstrate stable relationships with the other measures in the set. (PsycTESTS Database Record (c) 2014 APA, all rights reserved) KW - Katz Adjustment Scales KW - Patient Forms KW - Relative Forms KW - Social Behavior KW - Patient Functioning KW - Discriminative Validity KW - Pre-Psychotic Patients KW - Ex-Hospital Patients KW - Clinical Adjustment U5 - Katz Adjustment Scales (KAS) [Test Development]Methods for measuring adjustment and social behavior in the community: I. Rationale, description, discriminative validity and scale development. (AN: 1964-08391-001 from PsycINFO) Katz, Martin M.; Lyerly, Samuel B.; 1963. Source: Psychological Reports. 13(2), Psychological Reports, US; 1963; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Sample: Psychiatric Patients Keywords: Katz Adjustment Scales; Patient Forms; Relative Forms; Social Behavior; Patient Functioning; Discriminative Validity; Pre-Psychotic Patients; Ex-Hospital Patients; Clinical Adjustment; Subjects: Ability Level; Adjustment; Hospitalized Patients; Social Behavior; Test Validity; DO - 10.1037/t04041-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-04041-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - CHAP ID - 2007-15047-008 AN - 2007-15047-008 AU - Stern, Edith M. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - The aging and the aged. T2 - The encyclopedia of mental health, Vol I. Y1 - 1963/// SP - 153 EP - 178 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15047-008. Partial author list: First Author & Affiliation: Stern, Edith M.; National Institute of Mental Health, US. Release Date: 20071022. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Aging. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Page Count: 26. AB - The topics discussed in this entry include: the definition of aging and the aging process; mental abilities of the aging; sex drives of the aging; emotional problems of the aging; retirement and the decline of health and spirits in the aging; the physical health of the aged today compared to former times; life expectancy of the aged; attitudes toward the aged; rate of suicide in the aging; and mental disorders of the aged and treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - aging KW - aged KW - 1963 KW - Aging KW - 1963 DO - 10.1037/11558-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15047-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15047-013 AN - 2007-15047-013 AU - Kety, Seymour S. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Biological factors in mental illness. T2 - The encyclopedia of mental health, Vol I. Y1 - 1963/// SP - 227 EP - 234 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15047-013. Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20071022. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Biology; Mental Disorders. Classification: Psychological Disorders (3210). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. AB - The topics discussed in this entry include: enthusiasm regarding the biological basis of mental health; progress in the demonstrating biological bases for some biological illnesses; mental disorders caused by biological factors; biological factors role in major psychoses; biological factors shown in schizophrenia; serotonin's role in schizophrenia and reasons to support biochemical factors in schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - biological factors KW - mental disorders KW - 1963 KW - Biology KW - Mental Disorders KW - 1963 DO - 10.1037/11558-013 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15047-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15048-033 AN - 2007-15048-033 AU - Rosenthal, David ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Heredity and mental health. T2 - The encyclopedia of mental health, Vol II. Y1 - 1963/// SP - 724 EP - 735 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15048-033. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Genetics; Mental Health. Classification: Psychological & Physical Disorders (3200); Genetics (2510). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12. AB - The topics discussed in this entry include: the history of heredity and mental health; mental disorders that have been studied with respect to whether or not they are inherited; inherited schizophrenia; environmental factors important in causing schizophrenia; and the prospects for achieving a detailed understanding of the relationship between heredity and mental health. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health KW - heredity KW - 1963 KW - Genetics KW - Mental Health KW - 1963 DO - 10.1037/11549-033 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15048-033&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15050-006 AN - 2007-15050-006 AU - Stern, Edith M. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Mental retardation. T2 - The encyclopedia of mental health, Vol IV. Y1 - 1963/// SP - 1180 EP - 1203 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15050-006. Partial author list: First Author & Affiliation: Stern, Edith M.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Intellectual Development Disorder. Classification: Developmental Disorders & Autism (3250). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 24. AB - This entry discusses mental retardation. The topics covered include: Who are the mentally retarded; are there different degrees of mental retardation, if so, what are they, and what is their distribution among all the mentally retarded; what is the cause of mental retardation; how many persons in the United States are mentally retarded; how many of the mentally retarded are in institutions; do United States estimates of the prevalence of mental retardation differ from those of other countries; is the incidence of mental retardation in the United States greater in either of the sexes, at certain ages, in any particular national, racial, economic, or religious group,in rural or urban groups; is the number of mentally retarded in the United States increasing or decreasing, why; would euthanasia be preferable to keeping alive the severely retarded who give no evidence that they can ever contribute to the community or get anything out of life personally; what has been the history of society's attitude toward the mentally retarded; is mental retardation curable; is mental retardation preventable; are the mentally retarded identifiable by their appearance; what characteristics are common to the mentally retarded; is the mentally retarded individual aware of his difference, if so, how can he be helped to adjust to such awareness; what are some of the special emotional problems of the mentally retarded; is it possible for the mentally retarded to become mentally ill, if so, are there mental disorders that affect them especially; can psychotherapy be useful for mentally retarded persons; why do some mentally retarded children and adults have odd mannerisms such as repeating movements or words, or grinning or giggling without apparent reason; is mental retardation associated with epilepsy, cerebral palsy; how early can the symptoms of mental retardation be recognized; how and by whom is the diagnosis of mental retardation made; is it possible for the I.Q. of the mentally retarded to change; is it desirable for couples who have had a retarded child to have other children; what effect can a mentally retarded child have on the family; when ought the mentally retarded child to be put into residential care rather than to live at home; is the incidence of delinquency higher among the mentally retarded than among the general population; what are the sexual attributes of the mentally retarded; how prevalent are special classes in the public schools, what is taught in these classes; are the mentally retarded employable; ought the mentally retarded to marry; and what agencies are specifically concerned with mental retardation, do they adequately meet the need. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental retardation KW - 1963 KW - Intellectual Development Disorder KW - 1963 DO - 10.1037/11547-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15050-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15050-030 AN - 2007-15050-030 AU - Felix, Robert H. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - The National Institute of Mental Health. T2 - The encyclopedia of mental health, Vol IV. Y1 - 1963/// SP - 1292 EP - 1305 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15050-030. Partial author list: First Author & Affiliation: Felix, Robert H.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Government Agencies; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 14. AB - This entry discusses the National Institute of Mental Health. The topics covered include: what is The National Institute of Mental Health (NIMH); why was the NIMH created; how many professionals work at the NIMH; how has the Institute developed its program; what are the Institute's research interests; how is a research grant made; what are the Institute's training programs; how do the community services programs operate; what have been the Institute's past accomplishments; what are the Institute's future goals; and how do the programs of the NIMH fit into the other health activities of the Federal Government. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - National Institute Mental Health KW - 1963 KW - Government Agencies KW - Mental Health KW - 1963 DO - 10.1037/11547-030 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15050-030&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15051-013 AN - 2007-15051-013 AU - Shakow, David ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Psychology. T2 - The encyclopedia of mental health, Vol V. Y1 - 1963/// SP - 1618 EP - 1633 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15051-013. Partial author list: First Author & Affiliation: Shakow, David; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: History of Psychology; Psychologists; Psychology. Classification: General Psychology (2100). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16. AB - This chapter covers psychology. In particular, it discusses the aims of psychology; psychology's general principles; the major phenomena with which psychology deals; how psychology deals with these phenomena; psychology's history; the different schools of thought in psychology; what purpose different formulations and schools serve; is psychology a science; how does a psychologist differ from a psychiatrist; how many psychologists are there in the United States; is the present number adequate; do the number of psychologists differ in other countries; where and for whom do psychologists work; the salary levels; the various functions of the psychologist; the attitudes toward psychologists as therapists; the contributions of psychology as a science and as a profession; How everyday living has changed because of the results of the study of psychology; and the status of psychology and psychologists. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychology KW - psychologists KW - history KW - 1963 KW - History of Psychology KW - Psychologists KW - Psychology KW - 1963 DO - 10.1037/11559-013 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15051-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15051-015 AN - 2007-15051-015 AU - Cole, Jonathan O. AU - Cole, Kathleen G. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Psychopharmacology. T2 - The encyclopedia of mental health, Vol V. Y1 - 1963/// SP - 1654 EP - 1663 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15051-015. Partial author list: First Author & Affiliation: Cole, Jonathan O.; Psychopharmacology Service Center, National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Drug Therapy; Psychopharmacology. Minor Descriptor: Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 10. AB - This chapter covers psychopharmacology. Specifically, it looks at what is psychopharmacology; what kinds of drugs have psychopharmacological effects; major tranquilizers; minor tranquilizers; antidepressants; stimulants; psychotomimetics; if the new drugs will empty our mental hospitals; can the drugs currently used for the treatment of mental illness cure mental illness; how long must an emotionally ill person continue to take drugs; do these drugs have harmful effects if taken for a period of months or years; can these drugs be used to treat children who have emotional disorders; are psychopharmacologic agents used for the treatment of nonpsychiatric conditions; who can prescribe psychopharmacologic agents; do drugs interfere with psychotherapy; will drugs replace psychotherapy; do drugs interfere with driving; do drugs affect the patient's response to alcohol or other nonpsychoactive drugs; is it all right to borrow tranquilizing drugs from friends; can one become addicted to any of these drugs; do these drugs affect all people in the same way; are drugs useful in the treatment of alcoholism; can psychoactive drugs cure mental retardation; are these drugs helpful in psychiatric conditions of later life; does science understand how these drugs act; and will drugs be developed that can really cure mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychopharmacology KW - mental illness KW - 1963 KW - Drug Therapy KW - Psychopharmacology KW - Mental Disorders KW - 1963 DO - 10.1037/11559-015 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15051-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15053-006 AN - 2007-15053-006 AU - Kohn, Melvin L. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Social psychology. T2 - The encyclopedia of mental health, Vol VI. Y1 - 1963/// SP - 1925 EP - 1932 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15053-006. Partial author list: First Author & Affiliation: Kohn, Melvin L.; Laboratory of Socio-environmental Studies, National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Mental Health; Social Psychology. Minor Descriptor: Mental Disorders; Social Psychologists. Classification: Social Psychology (3000). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. AB - This chapter covers social psychology. In particular, it discusses the origins of social psychology; if social psychology has a characteristic way of explaining behavior; if there is a basic conflict between social psychology and psychoanalysis; some of the principal problems with which social psychologists are concerned; methods social psychologists use in their research; the sample survey; the ways that social psychology is relevant to mental illness; if there is any evidence that the individual's position in society has an appreciable effect on the likelihood of his becoming mentally ill; the ways in which social psychology is relevant to mental health; and what might be predicted about the methods and scope of social psychology in the near future. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - social psychology KW - mental health KW - mental illness KW - 1963 KW - Mental Health KW - Social Psychology KW - Mental Disorders KW - Social Psychologists KW - 1963 DO - 10.1037/11560-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15053-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-15053-012 AN - 2007-15053-012 AU - Korchin, Sheldon J. ED - Deutsch, Albert ED - Fishman, Helen ED - Deutsch, Albert, (Ed) ED - Fishman, Helen, (Ed) T1 - Stress. T2 - The encyclopedia of mental health, Vol VI. Y1 - 1963/// SP - 1975 EP - 1982 CY - New York, NY, US PB - Franklin Watts N1 - Accession Number: 2007-15053-012. Partial author list: First Author & Affiliation: Korchin, Sheldon J.; National Institute of Mental Health, US. Release Date: 20071029. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Stress. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 8. AB - This chapter covers stress. In particular, it looks at the difference between physical and psychological stress; some kinds of psychological stress; the major psychological reactions to stress; defense mechanisms; how stress and anxiety are related; is a certain amount of stress desirable; is minimal stimulation stressful; the relation between stress and bodily functioning; how does psychological functioning change under stress; do people differ in their stress resistance; is extreme stress a major factor in mental disease; and the stresses of present-day society. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychological stress KW - physical stress KW - 1963 KW - Stress KW - 1963 DO - 10.1037/11560-012 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15053-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-001 AN - 2007-02259-001 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Introduction. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 1 EP - 11 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Relations; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Daughters. Classification: Schizophrenia & Psychotic States (3213); Genetics (2510). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. AB - This book is essentially the historical account and clinical evaluation of a single family. As such it is primarily a case study, although its protagonists number six persons rather than one (a father and mother and identical quadruplet daughters who were schizophrenic in varying degrees). In an age when scientific methods have been developed in profusion and applied with considerable sophistication and self-consciousness to the study of behavior or behavioral disorder, it seems almost anachronistic to proffer to the scientific community a case study as a serious contribution to the advancement of psychological or psychiatric thought. A scientist who finds himself venturing such a claim must surely deem it judicious, if not actually compelling, to reflect on why he should attribute special importance to any single case, let alone to one in which he is personally invested. Specifically, I have asked myself two questions. First, what marks the case method as distinctive; what special features must a case or case study possess to give it special significance? Second, what special features do we find in our study of the Genain family that might give it a claim to scientific attention? (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - Genain family KW - quadruplet daughters KW - schizophrenia KW - 1963 KW - Family Relations KW - Multiple Births KW - Nature Nurture KW - Schizophrenia KW - Daughters KW - 1963 DO - 10.1037/11420-001 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-003 AN - 2007-02259-003 AU - Rosenthal, David AU - Raphling, Lois S. AU - Quinn, Olive W. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Anamnesis. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 22 EP - 149 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-003. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Background; Family Relations; Multiple Births; Patient History; Schizophrenia. Minor Descriptor: Birth; Daughters; Fathers; Marriage; Mothers; Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 128. AB - This chapter entitled anamnesis begins by discussing the early years of Henry Genain and of Gertrude Hood Genain. It then looks at the courtship and early marriage of Henry and Gertrude. Next, it discusses the birth of the quadruplets. The chapter goes on to describe the quads' preschool years, elementary years, junior-high school years, high-school years, and post-school years. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - Gertrude Hood Genain KW - Henry Genain KW - quadruplets KW - schizophrenia KW - preschool years KW - elementary years KW - junior high school years KW - high school years KW - post school years KW - birth KW - marriage KW - family background KW - 1963 KW - Family Background KW - Family Relations KW - Multiple Births KW - Patient History KW - Schizophrenia KW - Birth KW - Daughters KW - Fathers KW - Marriage KW - Mothers KW - Parents KW - 1963 DO - 10.1037/11420-003 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-004 AN - 2007-02259-004 AU - Rosenthal, David AU - Quinn, Olive W. AU - Raphling, Lois S. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - The NIH Years. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 150 EP - 160 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-004. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Multiple Births; Psychiatric Hospitalization; Psychotherapy; Schizophrenia. Minor Descriptor: Daughters; Living Arrangements; Parents. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 11. AB - The quads remained at NIH for three years. There was much discussion about whether the girls should live on the same or different wards or, if on the same ward, whether in the same or in different dormitories, in pairs or separately. Consequently, various living arrangements were tried. Each girl was assigned a different psychiatrist who was responsible for her treatment. No physical or drug therapy was given them, but they were encouraged to take advantage of the psychotherapy offered. While the girls lived at the Clinical Center, Mr. and Mrs. Genain visited them repeatedly, first for a month when the girls were admitted, and most other times for one-week periods. During these visits, they lived at the Clinical Center with their daughters. Each parent was assigned a social caseworker. During the periods between visits, Mrs. Genain's worker conducted interviews by telephone. Some of the main observations made on the separate members of the family are presented in this chapter. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - NIH Clinical Center KW - Genain quadruplets KW - Genain family KW - psychotherapy KW - schizophrenia KW - living arrangements KW - 1963 KW - Multiple Births KW - Psychiatric Hospitalization KW - Psychotherapy KW - Schizophrenia KW - Daughters KW - Living Arrangements KW - Parents KW - 1963 DO - 10.1037/11420-004 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-004&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-006 AN - 2007-02259-006 AU - Rosenthal, David AU - Quinn, Olive W. AU - Raphling, Lois S. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Follow-up. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 169 EP - 175 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-006. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Adjustment; Multiple Births; Prognosis; Psychiatric Hospitalization; Schizophrenia. Minor Descriptor: Sisters; Treatment. Classification: Schizophrenia & Psychotic States (3213); Inpatient & Hospital Services (3379). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 7. AB - This chapter describes followup with each of the Genain quadruplets. First, the chapter looks at Myra after she left Woodley House. The chapter then describes Nora, Iris, and Hester's time after leaving NIH and being admitted to Kenwood State Hospital. Nora was able to leave the hospital and marry. Though her course of adjustment has been marginal and uneven, the prospects of her remaining out of the hospital are reasonably good. During her better phases, Iris was permitted home visits for brief periods. Mrs. Genain and hospital personnel do not feel that she is well enough yet to live at home. The prognosis is guarded, but somewhat pessimistic. Hester, however, has never been home on leave and remains on a regressed ward. Her prognosis is poor. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - Genain quadruplets KW - hospitalization KW - followup KW - adjustment KW - prognosis KW - 1963 KW - Adjustment KW - Multiple Births KW - Prognosis KW - Psychiatric Hospitalization KW - Schizophrenia KW - Sisters KW - Treatment KW - 1963 DO - 10.1037/11420-006 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-007 AN - 2007-02259-007 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Psychiatric Disorders in the Families of Mr. and Mrs. Genain. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 176 EP - 178 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-007. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Background; Mental Disorders; Patient History; Psychopathology. Minor Descriptor: Multiple Births; Offspring; Parents. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 3. AB - Mrs. Genain's notebook contained the dates of birth and death and some fragments of medical or marital history of her husband's relatives and her own. We obtained additional information primarily through interviews with her. In the main, she portrayed her husband's family as abounding with various forms of psychopathology and her own family as being virtually free of mental disorders. The sharp contrast immediately raises questions about the accuracy of her reporting, but details of life history such as marital status, stability and fruitfulness of marriage, occupational history, manner of death, and some corroborative history by Henry's brother Raymond all suggest that though she may have accentuated or exaggerated various highlights of history to achieve the portrait of contrast, the general picture is essentially correct. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - psychiatric disorders KW - family history KW - Mr. & Mrs. Genain KW - psychopathology KW - 1963 KW - Family Background KW - Mental Disorders KW - Patient History KW - Psychopathology KW - Multiple Births KW - Offspring KW - Parents KW - 1963 DO - 10.1037/11420-007 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-007&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-008 AN - 2007-02259-008 AU - Allen, Gordon ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Zygosity of the Quadruplets. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 181 EP - 192 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-008. Partial author list: First Author & Affiliation: Allen, Gordon; Section on Community and Population Studies, Laboratory of Socio-Environmental Studies, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Genetics; Heterozygotic Twins; Monozygotic Twins; Multiple Births. Minor Descriptor: Schizophrenia; Sisters. Classification: Genetics (2510); Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 12. AB - Previous investigators, who studied the placenta, early physical resemblances, and qualitative features regard the Genain quadruplets as monozygotic. The addition of blood group tests to the criteria now tends to confirm the earlier conclusion. When probabilities are calculated by a modification of methods devised for twins, simple hereditary traits yield a probability above 99 per cent that the quadruplets are monozygotic. Some quantitative differences, especially fingerprints, appear more consistent with a two-egg origin, but statistics on these traits in other quadruplets do not exist. The evidence from qualitative traits so strongly supports the monozygotic hypothesis that the observed quantitative differences can probably be taken as a measure of the variation that is possible in identical quadruplets. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - zygosity KW - Genain quadruplets KW - monozygotic vs dizygotic KW - 1963 KW - Genetics KW - Heterozygotic Twins KW - Monozygotic Twins KW - Multiple Births KW - Schizophrenia KW - Sisters KW - 1963 DO - 10.1037/11420-008 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-009 AN - 2007-02259-009 AU - Bayley, Nancy ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Intellectual and Physical Development. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 193 EP - 201 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-009. Partial author list: First Author & Affiliation: Bayley, Nancy; Section on Early Development, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Academic Achievement; Intellectual Development; Multiple Births; Physical Development; Schizophrenia. Minor Descriptor: Intelligence; Intelligence Measures; Test Scores. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Arthur performance test; Henman-Nelson intelligence test; Wechsler Bellevue Intelligence Scale; Otis-Lennon School Ability Test; Stanford-Binet Intelligence Scale; Army Beta Examination. Methodology: Clinical Case Study; Empirical Study. Page Count: 9. AB - There is a considerable body of literature on the status of intellectual ability in the mental disorders. After an extensive, recent review of the topic, Payne (1961) stated that 'the bulk of the literature relates test results to psychiatric labels, and not to specific symptoms rated independently by unbiased observers, nor to other unambiguous data about the patients. Therefore it will be difficult to interpret most of the studies. Even if some correlations with psychiatric labels are observed, the reasons for these will not be clear. The behavioral correlates of specific cognitive dysfunctions can only be speculated about from the data so far available in the literature.' The quadruplets afford us an opportunity to compensate for some of the deficiencies to which Payne refers, in that the data about them are extensive and unambiguous, especially the data on their clinical condition during their illness. Moreover, their heredity is identical so that we do not have to be troubled by the possible contributions to current performance of differences in native endowment. This chapter presents intelligence test scores, school records, and physical growth records for the Genain quadruplets and discusses their results. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - intellectual & physical development KW - intelligence tests KW - Genain quadruplets KW - school records KW - physical growth KW - 1963 KW - Academic Achievement KW - Intellectual Development KW - Multiple Births KW - Physical Development KW - Schizophrenia KW - Intelligence KW - Intelligence Measures KW - Test Scores KW - 1963 DO - 10.1037/11420-009 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-010 AN - 2007-02259-010 AU - Evarts, Edward V. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Electroencephalographic Studies of the Genain Family. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 202 EP - 207 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-010. Partial author list: First Author & Affiliation: Evarts, Edward V.; Section on Physiology, Laboratory of Clinical Science, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Electroencephalography; Family Members; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 6. AB - EEG records were obtained once for Mr. and Mrs. Genain and several times over a period of two years for their four children. Records were obtained on a standard eight-channel machine, employing the electrode placements and recording combinations described by Cohn (1949). The results of these EEG exams are presented in this chapter, as well as a comment on the findings. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - electroencephalographic records KW - Genain family KW - 1963 KW - Electroencephalography KW - Family Members KW - Schizophrenia KW - 1963 DO - 10.1037/11420-010 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-011 AN - 2007-02259-011 AU - Zahn, Theodore P. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - GSR Responsivity. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 208 EP - 216 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-011. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Galvanic Skin Response; Psychophysiology; Schizophrenia. Minor Descriptor: Skin Resistance. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 9. AB - Many theories about the etiology of schizophrenia have focused on 'anxiety' or some state of hyperexcitability as a key variable. Its degree of presence is sometimes estimated clinically, sometimes on the basis of psychophysiological responses under somewhat controlled conditions. Among our early subjects we included the Genain family, but unfortunately, as under many other circumstances, Mr. Genain managed to avoid being tested. This procedure was undertaken in order to gain some notion of the level of arousal and autonomic responsivity of the girls. It involved the continuous measurement of galvanic skin resistance (GSR) during two sessions in which visual or auditory stimuli were presented repetitively. This chapter presents T. P. Zahn's account of the 'orienting' procedure and his analysis of the findings on the Genains. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - psychophysiological responses KW - galvanic skin resistance KW - Genain family KW - schizophrenia KW - 1963 KW - Family Members KW - Galvanic Skin Response KW - Psychophysiology KW - Schizophrenia KW - Skin Resistance KW - 1963 DO - 10.1037/11420-011 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-011&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-012 AN - 2007-02259-012 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Reaction time. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 217 EP - 221 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-012. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Reaction Time; Schizophrenia. Minor Descriptor: Multiple Births. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 5. AB - Probably no other laboratory procedure has as long a history, or has been applied to the psychological analysis of schizophrenia as often, as has the reaction time experiment. It has been shown again and again, in many different contexts, that groups of schizophrenic subjects respond motorically to a signal more slowly than groups of normal subjects. We originally intended to do several experiments with the Genian quadruplets, including the effects on set index of clinical conditions when heredity is controlled, and the relation of heredity and clinical condition to reaction time (RT) tasks of varying complexity. Unfortunately, Iris and Hester were unable to cooperate in the task and the plans had to be abandoned. A description of their behavior in the context of the reaction time situation is presented to give the reader a first-hand account of their response in a common novel setting which both experienced as stressful. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - reaction time situation KW - schizophrenia KW - Genain quadruplets KW - 1963 KW - Family Members KW - Reaction Time KW - Schizophrenia KW - Multiple Births KW - 1963 DO - 10.1037/11420-012 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-014 AN - 2007-02259-014 AU - Rosenthal, David AU - Lewinson, Thea Stein ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Handwriting of the Quadruplets during Morbid and Premorbid Conditions. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 227 EP - 240 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-014. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Handwriting; Personality; Premorbidity; Schizophrenia. Minor Descriptor: Evaluation; Multiple Births; Sisters. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 14. AB - The scientific status of handwriting analysis as a way of evaluating personality or psychopathology is still unsettled. Types of analysis have been classified as intuitive and objective. Mrs. Lewinson is one of the foremost exponents of objective analysis, which is based on a number of readily measurable signs We intended to ask an expert to provide the analysis without knowing anything about the subjects. Mrs. Lewinson graciously agreed to such an arrangement. Unfortunately, because of an accident of communication, she learned that the subjects were schizophrenic identical quadruplets and we had to revise our plans. However, Mrs. Lewinson knew nothing more than that about the girls or their histories. After she had made her reports and ratings based on the girls' high school handwriting specimens, we submitted to her a second group of samples, obtained while the girls were hospital patients (ages twenty-eight to twenty-nine). We deliberately did not tell Mrs. Lewinson which of the four later samples corresponded to the four earlier ones. But the attempt to preserve even this much anonymity proved pointless; Mrs. Lewinson immediately matched, correctly and with complete confidence, the earlier and later samples. For each handwriting sample, Mrs. Lewinson was to present graphs descriptive of the subject's personality and psychopathology in five areas of functioning, according to formulations which she has developed and presented elsewhere (Lewinson and Zubin, 1942; Lewinson, 1961). She was also asked to write a full personality evaluation and to rate each subject on sixty selected traits. A summary of the personality evaluations and an analysis of the ratings are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - schizophrenic quadruplets KW - handwriting analysis KW - personality evaluations KW - premorbid & morbid conditions KW - 1963 KW - Handwriting KW - Personality KW - Premorbidity KW - Schizophrenia KW - Evaluation KW - Multiple Births KW - Sisters KW - 1963 DO - 10.1037/11420-014 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-014&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-016 AN - 2007-02259-016 AU - Kendig, Isabelle V. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - The Draw-a-Person Test. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 257 EP - 268 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-016. Partial author list: First Author & Affiliation: Kendig, Isabelle V.; National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Drawing; Personality Traits; Projective Personality Measures; Schizophrenia. Minor Descriptor: Multiple Births; Siblings. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 12. AB - The Draw-a-Person test is given mostly for diagnostic purposes and for evaluating various personality traits, such as self-image, sexual identification, feelings of insecurity, etc. As is true of many projective tests, the material elicited often has high impact and interest value, and when first confronted by the drawings, one often experiences a sense of surprise or revelation. However, attempts to obtain consensus or validation regarding the meaning of the material obtained are usually less than satisfactory. Nevertheless, since the Draw-a-Person test enjoys such widespread clinical use, is usually obtainable from subjects who cannot or will not perform on other tests, and has intrinsic interest because of the material it provides, we gave the test to the Genain girls. Two of the girls were testable when they first arrived at the Clinical Center. Subsequently Dr. Kendig, with great clinical skill, was able to test all four. This chapter provides Dr. Kendig's clinical evaluation of the drawings obtained at the earlier testings and those she obtained herself. I asked Dr. Kendig to summarize the similarities and differences in the girls' performance and to make ratings of various personality characteristics based on the girls' test performance. However, she preferred not to make the kind of inferences involved in the latter task. The reader may examine the drawings and Dr. Kendig's account of them and make his own comparisons and interpretations, if he is so inclined. Two points are clear. The drawings vary markedly from girl to girl and from time to time in the case of Myra and Nora; but a few similarities can be detected, as between Myra's first female figure and Iris' male figure, or the hands drawn by Myra and the hands drawn by Iris. Yet it is evident that the character of the drawings is far more sensitive to the clinical condition of the girls than to any genetic factors, whether the latter are the ones that may bear on the schizophrenic process or not. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - projective tests KW - Draw-a-Person test KW - schizophrenia KW - personality characteristics KW - 1963 KW - Drawing KW - Personality Traits KW - Projective Personality Measures KW - Schizophrenia KW - Multiple Births KW - Siblings KW - 1963 DO - 10.1037/11420-016 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-016&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-018 AN - 2007-02259-018 AU - Rosenthal, David AU - Piotrowski, Zygmunt A. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - The Beck-Molish Rorschach Typology with Respect to the Genain Family. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 307 EP - 314 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-018. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Family Members; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Evaluation; Testing. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Beck-Molish Q-sort evaluation. Methodology: Clinical Case Study; Empirical Study. Page Count: 8. AB - Rorschach's Psychodiagnostik first appeared in 1921. Eight years later, M. Bleuler (1929) published the first article purporting to show whether hereditary as well as environmental factors influenced performance on 'Rorschach's experiment.' In a subsequent article which appeared in the first volume of Character and Personality (1933), he summarized his findings. In this chapter, we shall open again the original question raised by Bleuler, this time however using a method which evaluates the entire record in the integrative fashion recommended. The following is an account of how the study was done, its rationale, and the results we obtained. After Dr. Piotrowski had completed his analyses of the sixteen protocols submitted to him, he was told that ten of the protocols belonged to members of the same family and that some records represented repeated testings of the same person. He was also told that the family was a most unusual one, but nothing was said about what made it unusual, nor did Dr. Piotrowski guess at any time that a multiple birth was involved. It was suggested that before we told him the whole story about the family, we should have a Beck-Molish Q-sort evaluation of each record. Although the Q-sorting is an onerous task, and although he knew nothing about the reason for doing it, Dr. Piotrowski went along with the suggestion. The Q-type descriptions which he provided represent the raw data of this chapter. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - multiple birth KW - Beck-Molish Q-sort evaluation KW - environmental factors KW - Genain family KW - heredity KW - 1963 KW - Family Members KW - Multiple Births KW - Nature Nurture KW - Schizophrenia KW - Environment KW - Evaluation KW - Testing KW - 1963 DO - 10.1037/11420-018 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-018&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-036 AN - 2007-02259-036 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Possible environmental factors: Life-experience. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 347 EP - 374 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-036. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Anxiety Management; Cognitive Processes; Life Experiences; Schizophrenia; Socialization. Minor Descriptor: Anxiety; Daughters; Environment; Failure; Family; Fathers; Multiple Births; Psychological Theories; Sisters. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 28. AB - The history of the Genain family is fairly detailed and most of it is well documented, but in fact it represents only a minute, fragmented, secondhand account of six people's lives. Compared to other case histories, it stands up well. Compared to an ideal that we would all like to achieve, it leaves much to be desired. Even so, it is a simple matter to glean evidence from the history to support almost any of the currently favored psychological theories. Dr. Perlin has pointed to the symbiosis between Myra and her mother. Wynne et al. (1957) have described the pattern of pseudo-mutuality in the family. Mrs. Basamania has indicated how Mrs. Genain's relationship to each of her daughters derived from one of her own unresolved childhood conflicts. The history imparts the picture of a dominant mother who runs the family, and a weak father who cannot cope with her except through threat of violence and who cannot represent a major link between the family and the community. We have clear evidence of double-binding and have provided quotes at different points in the text to illustrate it. Patterns of 'irrationality' are clearly visible in both parents, with indications of the ways the girls became caught up in these patterns. Each quad is a picture of gradually accelerating and expanding anxiety, and the ways the environment contributed to it are shown for each quad. The problem is not to find evidence in the history that such or other relevant events did in fact occur, but rather to determine which, if any, contributed to the development of schizophrenic reactions in the quads. If for the moment we ignore the specific details of the many dynamic or psychological theories proposed to date, we can group them in at least three ways, all of which represent a kind of failure of learning: (1) failure of socialization; (2) failure of cognitive integration; (3) failure to contain anxiety. The three are clearly interrelated, but the focus in each is on one variable which is seen to be primary in the progression of schizophrenic illness, the other two developing secondarily as concomitant effects of the primary condition. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - schizophrenia KW - Genain family KW - quadruplet sisters KW - life experiences KW - failure KW - socialization KW - cognitive integration KW - anxiety control KW - 1963 KW - Anxiety Management KW - Cognitive Processes KW - Life Experiences KW - Schizophrenia KW - Socialization KW - Anxiety KW - Daughters KW - Environment KW - Failure KW - Family KW - Fathers KW - Multiple Births KW - Psychological Theories KW - Sisters KW - 1963 DO - 10.1037/11420-036 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-036&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-022 AN - 2007-02259-022 AU - Quinn, Olive W. AU - Stein, Johanna ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Social Interaction Patterns of the Quadruplets. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 373 EP - 387 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-022. Partial author list: First Author & Affiliation: Quinn, Olive W.; Goucher College, Towson, MD, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Hospitalized Patients; Psychiatric Patients; Schizophrenia; Social Behavior; Social Interaction. Minor Descriptor: Multiple Births; Sisters. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study; Qualitative Study. Page Count: 15. AB - Observation of the quads' ward behavior was undertaken to describe systematically each girl's social behavior. Did the girls differ in this respect? Was there a functioning hierarchy? Were there observable subgroups? Isolates? The observations were conducted when each quad was residing in a separate room with a nonquad roommate; this arrangement eliminated the involuntary associations produced when sisters were roommates. Each subject was observed for comparable time periods for a sample week of three days: (1) a week day in which the subject had therapy; (2) a week day on which the subject did not have therapy; and (3) a week-end day, when staff and activities were different. The following kinds of information were coded from the observation record: 1. All interactive behavior initiated and received by the quad in focus. Behavior directed to or received from another quad was so specified; for others only the class of individual was specified, i.e., staff member, observer, or patient. 2. The content and affect of interaction, including interactions that called for but did not receive a response. 3. The quads' noninteractive behavior, including nondirected gestures or speech. 4. The setting and all persons potentially available for interaction. 5. Periodic time checks, in which the observer records either that the quad is not doing anything or is continuing an action recorded earlier in the same observation unit. Findings on the following are presented: general frequency of observed behavior, interaction at varied social distance, interaction patterns among quadruplets; quad-quad behavior. A synthesis and interpretation is presented of triads, dyads, and isolation and freedom. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - social interaction KW - Genain quadruplets KW - social behavior KW - ward behavior KW - sisters KW - schizophrenia KW - 1963 KW - Hospitalized Patients KW - Psychiatric Patients KW - Schizophrenia KW - Social Behavior KW - Social Interaction KW - Multiple Births KW - Sisters KW - 1963 DO - 10.1037/11420-022 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-022&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-023 AN - 2007-02259-023 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Ratings of Disturbance in Various Categories of Behavior during Hospitalization. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 388 EP - 397 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-023. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior; Hospitalization; Schizophrenia. Minor Descriptor: Etiology; Multiple Births; Sisters. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. Page Count: 10. AB - Clearly, the most critical problem surrounding the etiology of schizophrenia from a biological point of view is: If something is inherited in schizophrenia, what is it? The question is generally approached in either of two ways. The first begins with a theoretical view of schizophrenia: for example, viewing the illness as the consequence of failure to adapt on a biological level to stressful situations. This view would hold it reasonable to be concerned with the metabolites of epinephrine and norepinephrine, which are the main humoral mediators of an organism's response to stress. One's search would be concerned with all the metabolic pathways in which these hormones are involved, with discovering a particular point in the metabolic process at which a breakdown or blockage of the process occurs in schizophrenic subjects (Hoffer, Osmond, and Smythies, 1954) and then determining if it is the tendency to develop this particular aberrancy which is inherited. As yet, no such point has been found, but this kind of search is being vigorously pursued on many fronts (Kety, 1959a, 1959b). The second approach begins with a clinical rather than a theoretical view of schizophrenia. It concerns itself with the patterns or sequences of symptomatology which occur in widely diverse forms in the disorders called schizophrenic. The aspects of the illness studied include time of onset, kind or degree of thinking disturbance, psychomotor deviations, the occurrence of particular symptoms or clusters of symptoms, emotional anomalies, Kraepelinian or other subtypes, the tendency toward deteriorative or nondeteriorative outcomes, and so on. Research in this instance is concerned with whether such aspects of the illness are closely associated in twins or families in a pattern of quantitative relationships, which would offer support to the view that these aspects are indeed inherited. The literature on this subject is so varied in substance and method that no one has yet attempted a detailed systematic integration of it, although a few partial summaries are available (Slater, 1947; Planansky, 1955; Rosenthal, 1959). This is not the place to attempt such an integration, although in Part VI I shall discuss in fair detail some of these issues that have special relevance to the findings on the Genains. The report in this chapter is particularly germane to this problem. It is based on a quantitative evaluation of various behavioral disturbances found in the quadruplets while they were hospitalized at the Clinical Center. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - behavior disturbances KW - Genain quadruplets KW - schizophrenia KW - hospitalization KW - etiology KW - 1963 KW - Behavior KW - Hospitalization KW - Schizophrenia KW - Etiology KW - Multiple Births KW - Sisters KW - 1963 DO - 10.1037/11420-023 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-023&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-024 AN - 2007-02259-024 AU - Schaefer, Earl S. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Parent-Child Interactional Patterns and Parental Attitudes toward Child-Rearing. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 398 EP - 430 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-024. Partial author list: First Author & Affiliation: Schaefer, Earl S.; Section on Early Development, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Childrearing Practices; Multiple Births; Parent Child Relations; Parental Attitudes; Schizophrenia. Minor Descriptor: Daughters; Fathers; Mothers. Classification: Schizophrenia & Psychotic States (3213); Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study; Empirical Study. Page Count: 33. AB - In recent years, several different kinds of studies have been done to evaluate the contribution of parents' behavior to the subsequent development of schizophrenic reactions in their offspring. Some studies have been based on the reports of the patients themselves (Reichard and Tillman, 1950; Limentani, 1956; Kohn and Clausen, 1956), some on the reports and observations of the parents during fairly intensive interviews (Gerard and Siegel, 1950; Tietze, 1949; Alanen, 1958). Several have obtained expressed attitudes about formally written items, as in attitude scales, comparing the parents of schizophrenic and of nonschizophrenic subjects with respect to these verbally expressed attitudes (Shoben, 1949; Mark, 1953; Freeman and Grayson, 1955). Some investigators have tried to make inferences about pathogenic parental behaviors by giving their patients tests involving either attitudes to parents or responses to stimuli depicting parental figures or behaviors (Brecher, 1956; Rodnick and Garmezy, 1957; Lidz, Cornelison, Fleck, and Terry, 1958). One investigator confronted both parents of schizophrenic subjects with differences between them in expressed child-rearing attitudes, and asked them to resolve these differences (Farina, 1960). None of these methods is entirely satisfactory. Ideally, we should like to have firsthand observations of parental behaviors with respect to children who later become schizophrenic and children who do not. In this chapter, we shall be concerned primarily with observations of parent-child interactions made at the Clinical Center. Mr. and Mrs. Genain visited the quadruplets at fairly frequent intervals, the visits lasting from a week to a month at a time. The parents lived in a room on the ward and had ready access to their daughters; they could spend time with them during the day or evening as they wished. Thus, although still artificial and restrictive, the situation nevertheless permitted a wide range of behavior. Topics covered in this chapter include mother-quad interactions, father-quad interactions, father-mother-quad interactions, Mr. Genain's attitudes toward childrearing, discussion of paternal attitudes, Mrs. Genain's attitudes toward child-rearing, and discussion of maternal attitudes. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - schizophrenia KW - childrearing attitudes KW - parental attitudes KW - parent-child interactional patterns KW - Genain quadruplets KW - 1963 KW - Childrearing Practices KW - Multiple Births KW - Parent Child Relations KW - Parental Attitudes KW - Schizophrenia KW - Daughters KW - Fathers KW - Mothers KW - 1963 DO - 10.1037/11420-024 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-024&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-026 AN - 2007-02259-026 AU - Hirsch, Stanley I. ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - A Caseworker's View of Mr. Genain. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 441 EP - 448 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-026. Partial author list: First Author & Affiliation: Hirsch, Stanley I.; Mental Health Social Service, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Father Child Relations; Marital Relations; Multiple Births; Social Casework. Minor Descriptor: Schizophrenia. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 8. AB - This chapter provides the authors experiences and observations of Mr. Genain. The author became the caseworker for Mr. Genain when Mr. Genain was sixty-six years old. Topics covered in this chapter include his relationship with his wife, relationship to the quads, and casework with Mr. Genain. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - Mr. Genain KW - casework KW - relationships KW - wife KW - daughters KW - quadruplets KW - schizophrenic children KW - 1963 KW - Father Child Relations KW - Marital Relations KW - Multiple Births KW - Social Casework KW - Schizophrenia KW - 1963 DO - 10.1037/11420-026 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-026&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-030 AN - 2007-02259-030 AU - Parloff, Morris B. AU - Stephenson, William AU - Perlin, Seymour ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Myra's Perception of Self and Others. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 493 EP - 501 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-030. Partial author list: First Author & Affiliation: Parloff, Morris B.; Section on Personality, Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Morality; Psychotherapeutic Processes; Psychotherapy; Self-Perception; Values. Minor Descriptor: Hospitalization; Multiple Births; Sisters; Therapist Attitudes. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Female (40); Inpatient (50). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Rosenthal Moral Values Q-set; California Q-Sort. Methodology: Clinical Case Study; Empirical Study. Page Count: 9. AB - Although each member of a multiple birth has a problem in establishing his own identity, Myra found the task especially difficult. A goal of therapy was, therefore, to help Myra establish more clearly her own ego boundaries. The study reported here had two main goals: (1) to trace the changes in Myra's consciousness of herself and her perceptions of other persons who played a significant role in her life; (2) to study the nature of the changes in both the patient's and therapist's treatment goals and in the therapist's perception of her. The investigation period covered the first two years of Myra's hospitalization. To determine the nature and modifications of the patient's perceptions of self, family and others, therapy goals, and how she appeared to her family and others, two sets of Q-sort cards with self-referent items were sorted under a number of different instructional sets during a twenty-three-month therapy period. The therapist also sorted the two Q-decks to describe Myra's attitudes and behaviors, his treatment goals for her, and his expectations of how Myra would describe him. Based on the Principal Components analysis of both Q-set matrices, Myra appears to perceive her mother as the member of the family most congenial to her. Myra's father and sisters, in contrast, are alien to her in that they appear on components characterized by pathology and rigid morality. Myra is able to identify with her mother and views her as representing attitudes and behaviors which Myra hopes to achieve in psychotherapy. However, Myra views these attitudes as representing male attitudes and prerogatives. She perceives the family as sharing a rather formidable set of values. Myra believed that her family and her therapist perceived her in quite different ways, neither of these personae was in accord with her own view of herself. On neither Q-set do the patient and therapist appear to have come to any agreement regarding the goals of treatment, perhaps because the therapist in his analytic role remained a fairly ambiguous figure. Perhaps the most significant finding lies not in the nature of the components defined but in the fact that Myra could not attribute her picture of her attitudes and behavior (California Q-set) to anyone outside herself, whereas she could do so easily under comparable conditions on the Moral Values Q-set. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - Myra Genain KW - Genain quadruplets KW - self perception KW - perception of others KW - therapy goals KW - values KW - morals KW - therapist's perception KW - hospitalization KW - 1963 KW - Morality KW - Psychotherapeutic Processes KW - Psychotherapy KW - Self-Perception KW - Values KW - Hospitalization KW - Multiple Births KW - Sisters KW - Therapist Attitudes KW - 1963 DO - 10.1037/11420-030 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-030&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-031 AN - 2007-02259-031 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - A suggested conceptual framework. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 505 EP - 511 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-031. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Etiology; Schizophrenia; Theories. Minor Descriptor: Biochemistry; Diathesis Stress Model; Genetics; Life Experiences; Stress. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 7. AB - So many theories of the etiology of schizophrenia (or dementia praecox) have been proposed during the relatively brief time since its postulation and general acknowledgment as a disease entity (1896) that it becomes almost impossible to deal with them separately. Many are in disrepute, or at least out of fashion, and probably better forgotten. Others hang on precariously, sometimes serving as the basis for further research, sometimes providing a basis for a new theory which is often an excrescence on the old. Others continue to be proposed with almost each new discovery about brain anatomy or function, about certain new metabolites or metabolic pathways, newly synthesized drugs which are thought to influence or simulate schizophrenic behavior, and loosely formulated psychological or psychiatric concepts which have often soared into prominence only to be replaced shortly in general favor by others which the rapidly changing professional temper has somehow found more congenial. For purposes of our discussion, these varied proposals may be grouped in three ways to provide at least the semblance of a conceptual framework in which to consider with greater effect the many findings on the Genains. The three types discussed in this chapter are monogenic-biochemical theories, diathesis-stress theories, and life experience theories. The chapter closes with a discussion of the problem of multiple etiologies. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - schizophrenia KW - etiology KW - conceptual framework KW - theories KW - monogenic-biochemical & diathesis-stress & life experience theories KW - 1963 KW - Etiology KW - Schizophrenia KW - Theories KW - Biochemistry KW - Diathesis Stress Model KW - Genetics KW - Life Experiences KW - Stress KW - 1963 DO - 10.1037/11420-031 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-031&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-032 AN - 2007-02259-032 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Possible Inherited Factors: EEG Abnormality. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 512 EP - 516 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-032. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Biochemistry; Electroencephalography; Genetics; Schizophrenia; Theories. Minor Descriptor: Genes; Multiple Births. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - From the point of view of monogenic-biochemical theory, one must be able to cite the specific biochemical imbalance that causes the illness if one is to contribute to basic knowledge. Unfortunately, no studies relevant to such a theory were attempted on the Genains. However, it is probable that such studies are better done on a variety of schizophrenic subjects, in whom the postulated mutant gene is imbedded in a wide diversity of genotypes, thereby minimizing the confounding of the implicated genetic effect with effects due to a common overall genotype, as in monozygotic twins or quadruplets. Thus, any findings of this study which suggest that there are inherited factors involved in the illness must either be considered as secondary signs of such a biochemical imbalance or as supportive of diathesis-stress theory. This chapter explores electroencephalographic abnormality. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - monogenic-biochemical theory KW - schizophrenic subjects KW - electroencephalographic abnormality KW - Genain quadruplets KW - 1963 KW - Biochemistry KW - Electroencephalography KW - Genetics KW - Schizophrenia KW - Theories KW - Genes KW - Multiple Births KW - 1963 DO - 10.1037/11420-032 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-032&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-033 AN - 2007-02259-033 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Possible Inherited Factors: Clinical Features of Schizophrenic Illness. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 517 EP - 529 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-033. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Disease Course; Genetics; Onset (Disorders); Schizophrenia; Subtypes (Disorders). Minor Descriptor: Multiple Births; Treatment Outcomes. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 13. AB - Unfortunately, there has been a paucity of studies dealing with separate aspects of clinical schizophrenia from the standpoint of heredity. We will briefly review some of the main ones relevant to the Genains, including: subtypes; age of onset; and, course and outcome. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - inherited factors KW - clinical schizophrenia KW - heredity KW - Genain quadruplets KW - subtypes KW - age of onset KW - course KW - outcome KW - 1963 KW - Disease Course KW - Genetics KW - Onset (Disorders) KW - Schizophrenia KW - Subtypes (Disorders) KW - Multiple Births KW - Treatment Outcomes KW - 1963 DO - 10.1037/11420-033 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-033&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-034 AN - 2007-02259-034 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Possible Inherited Factors: Patterns of Behavioral Disturbance, Premorbid Personality, and Test Performance. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 530 EP - 540 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-034. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Behavior Problems; Genetics; Performance; Personality; Schizophrenia. Minor Descriptor: Handwriting; Intelligence; Multiple Births; Premorbidity; Test Performance. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11. AB - Do the sequences of catatonic-hebephrenic progression and the patterns of behavioral disturbance during schizophrenic psychosis reflect a continuation and exacerbation of prepsychotic personality traits which may themselves have some hereditary basis? If so, we would have additional support for diathesis-stress theory, and at a practical level, we should be able to predict from the behavioral patterns of early childhood whether a given child would manifest a predominantly catatonic-hebephrenic syndrome if he became overtly schizophrenic or not. How can we possibly identify these personality characteristics of the Genain children which may have been harbingers of schizophrenia due in large part to heredity? The best we can hope to do is to indicate those personality characteristics which all the people who knew them attributed to all four girls, to determine from the literature whether there are indications that such traits are influenced by heredity, and to evaluate the evidence indicating that such traits are associated with the occurrence of clinical schizophrenia. The traits we would be most directly concerned with would be the ones which were prominent during the girls' subsequent psychosis, traits involving underactivity, verbal constriction, depressiveness, and social avoidance behavior, all implying excessive constraint or inhibition of response. From the many interviews of teachers, acquaintances, and relatives of the girls, we found that the kinds of adjectives used to describe all four included: not much energy, frail, pallid, tired easily; not forward, not aggressive, sweet, quiet, sedate, nice, reserved but outwardly friendly, no initiative, did what they were told, not popular, stand-offish, liked to be by themselves; scared, fearful, anxious, hard-working. A section on characteristics of performance and response brings together and summarizes briefly the main findings relevant to the possible inheritance of performance with respect to the procedures employed in studying the Genains. We are primarily concerned with those aspects that may have relevance to the development of schizophrenic illness. Topics covered in this section include handwriting, intelligence, and test responses. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - premorbid personality KW - inherited factors KW - behavior disturbance KW - test performance KW - Genain quadruplets KW - handwriting KW - schizophrenia KW - intelligence KW - 1963 KW - Behavior Problems KW - Genetics KW - Performance KW - Personality KW - Schizophrenia KW - Handwriting KW - Intelligence KW - Multiple Births KW - Premorbidity KW - Test Performance KW - 1963 DO - 10.1037/11420-034 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-034&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-035 AN - 2007-02259-035 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - Possible environmental factors: Prenatal influences. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 541 EP - 546 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-035. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Environment; Prenatal Development; Schizophrenia. Minor Descriptor: Etiology; Life Experiences; Multiple Births; Stress. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. Page Count: 6. AB - Although the literature on the genetics of schizophrenia is extensive, unwieldy, and inconclusive, our knowledge of environmental factors as possible etiologic agents in schizophrenia is based largely on precarious inferences from clinical case histories, epidemiological and ecological surveys, interviews of families, psychotherapy reports, and experimental studies on the psychology of schizophrenic patients. This literature taken en masse is truly forbidding, and makes the genetics literature seem almost unitary and lucid by comparison. Although the psychotherapy and case reports sometimes have a convincing ring, they are based on arbitrarily selected cases in which the possible effects of endogenous factors are usually not considered. The theorizing about such cases still reflects schools of thought--Freudian, Meyerian, Sullivanian, Jungian, Rogerian, existentialist--and often involves conjecture, dogma, and loose theorizing as much as thought (Rosenthal, 1961b). Among the better done epidemiological and ecological studies, the findings reported could easily be interpreted to be consistent with a genetic theory of schizophrenia. The experimental studies on the psychology of schizophrenia seem often to go counter to one another, and even if we consider only those findings that are consistent with a possible psychological etiology, the inference that current performance during the psychotic state accurately reflects early actual experiences which in turn brought on the psychosis is clearly saltatory. I will not repeat here the comments in my introductory note to Dr. Schaefer's analysis of parent-child interaction, where I reflected briefly on the problems of methodology and interpretation in family studies of schizophrenia. All things considered, I can see little profit in reviewing bodies of literature relevant to points about the Genains when considering possible psychogenic factors, as I did when discussing possible genetic factors. I shall try, however, to evaluate briefly our knowledge about possible prenatal factors in schizophrenia, considering their relevance to the illness in the quads. Then I shall cursorily examine the case history material and the various studies on the Genains, profiting as I can from the analyses and thinking of my fellow contributors, and highlight the kinds of stresses or life experiences that may have been implicated in the different courses of illness observed in the quadruplets. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - prenatal influences KW - environmental factors KW - schizophrenia KW - Genian quadruplets KW - stresses KW - life experiences KW - 1963 KW - Environment KW - Prenatal Development KW - Schizophrenia KW - Etiology KW - Life Experiences KW - Multiple Births KW - Stress KW - 1963 DO - 10.1037/11420-035 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-035&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-02259-037 AN - 2007-02259-037 AU - Rosenthal, David ED - Rosenthal, David ED - Rosenthal, David, (Ed) T1 - The Nature of the Heredity-Environment Interaction. T2 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// SP - 575 EP - 579 CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-037. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Genetics. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5. AB - I have not read or talked to any serious investigator of the heredity-environment problem in schizophrenia who has not in some way or other indicated that, in his opinion, both contributed to the disorder. The disagreements usually have arisen in regard to the relative importance attached to each and the kinds of genetic or environmental factors thought to be involved. Those who emphasize the genetic contribution seldom consider in earnest the role that environment might play, and environmentalists usually pay lip service to the idea that hereditary factors may eventually have to be considered as well. A theoretical reconciliation of the two is not easily effected. I should like here to present briefly several models of heredity-environment interaction that are implicit in various theories of schizophrenia. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - heredity-environment interaction KW - environmental factors KW - hereditary factors KW - genetic contribution KW - schizophrenia KW - theories KW - 1963 KW - Nature Nurture KW - Schizophrenia KW - Environment KW - Genetics KW - 1963 DO - 10.1037/11420-037 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-037&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - BOOK ID - 2007-02259-000 AN - 2007-02259-000 AU - Rosenthal, David ED - Rosenthal, David T1 - The Genain quadruplets: A case study and theoretical analysis of heredity and environment in schizophrenia. Y1 - 1963/// CY - New York, NY, US PB - Basic Books N1 - Accession Number: 2007-02259-000. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20070305. Correction Date: 20170227. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Family Relations; Genetics; Multiple Births; Nature Nurture; Schizophrenia. Minor Descriptor: Environment; Family Members. Classification: Schizophrenia & Psychotic States (3213); Genetics (2510). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Clinical Case Study. References Available: Y. Page Count: 609. AB - This book focuses on the Genian quadruplets, all of whom were schizophrenic. The book could have been written in many ways. The case history material could have been presented by themes or topics, such as intrafamilial relationships, sexuality, dependency, and so on. Or each quadruplet could have been traced separately, with a later attempt to interrelate the separate histories. But I have decided to present the material chronologically with respect to the family as a unit, trying to recapture the coursing problems, moods, assumptions, and decisions which beset the family members over the years and which eventually entangled them together in a net of circumstances that tightened more and more around each as they struggled to free themselves from it. Since six persons are involved, it is necessary in such a presentation to focus now on one, now on another, in a sense moving the spotlight where the family itself has directed. This may at times make the presentation appear jumpy and uneven, but hopefully it mirrors what actually occurred. The case history comprises the first part of the book. The second part presents tests and studies dealing with some basic characteristics and response processes. The third section consists of various protective tests and their analyses. The fourth involves systematic analyses of observations of the family by NIH staff and by the community. Part five presents some conceptualizations of family members and their interrelationships. Finally, I have presented a theoretical analysis of the heredity-environment problem in schizophrenia, summarizing the basic issues that apply to the Genains and our current knowledge about those issues, and indicating how this study illuminates them. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - heredity KW - environment KW - Genain quadruplets KW - schizophrenia KW - intrafamilial relationships KW - 1963 KW - Family Relations KW - Genetics KW - Multiple Births KW - Nature Nurture KW - Schizophrenia KW - Environment KW - Family Members KW - 1963 DO - 10.1037/11420-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02259-000&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Rheingold, Harriet L. AU - Stanley, Walter C. T1 - DEVELOPMENTAL PSYCHOLOGY. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1963/02// VL - 14 IS - 1 M3 - Article SP - 1 EP - 28 PB - Annual Reviews Inc. SN - 00664308 AB - The article presents a study on developmental psychology with emphasis on the stimulus control of both human and animal subjects and offers an analysis of learned behavior in immature organisms. It determines the effects of various kinds of deprivation and stimulation. Moreover, it provides an analysis of learned behavior including the types of reinforcers and parameters of reinforcement, discriminative stimulus control, and the role of response. KW - DEVELOPMENTAL psychology KW - DEVELOPMENTAL biology KW - CONDITIONED response KW - PSYCHOLOGY of learning KW - BEHAVIOR modification KW - STIMULUS satiation N1 - Accession Number: 32898265; Rheingold, Harriet L. 1; Stanley, Walter C. 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 1963, Vol. 14 Issue 1, p1; Subject Term: DEVELOPMENTAL psychology; Subject Term: DEVELOPMENTAL biology; Subject Term: CONDITIONED response; Subject Term: PSYCHOLOGY of learning; Subject Term: BEHAVIOR modification; Subject Term: STIMULUS satiation; Number of Pages: 28p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=32898265&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Butler, Robert N. T1 - Psychiatric evaluation of the aged. JO - Geriatrics JF - Geriatrics Y1 - 1963/03// VL - 18 IS - 3 M3 - Article SP - 220 EP - 232 SN - 0016867X N1 - Accession Number: 17107737; Butler, Robert N. 1; Source Information: Mar1963, Vol. 18 Issue 3, p220; Number of Pages: 13p; Illustrations: 9 Black and White Photographs, 2 Charts; Document Type: Article; Full Text Word Count: 4741 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17107737&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Harris, T.N. AU - Dray, Sheldon AU - Ellsworth, Barbara AU - Harris, Susanna T1 - Rabbit Gamma-Globulin Allotypes as Genetic Markers for the Source of Antibody Produced in Recipients of Shigella-Incubated Lymph Node Cells. JO - Immunology JF - Immunology Y1 - 1963/03// VL - 6 IS - 2 M3 - Article SP - 169 EP - 178 SN - 00192805 AB - Rabbits homozygous for each of an allelic pair of allotypes of γ globulin (A4 and A5) were used as donors and recipients of transferred antigen-incubated lymph node cells, the cells of donors of one allotype being in each case transferred to recipients of the other. When agglutinins to Shigella (the source of the antigen with which the lymph node dells were incubated) appeared in the sera of the recipient animals, the allotype of the agglutinin was determined by adsorbing it to Shigella on a glass slide, then treating the preparations with fluorescein-conjugated rabbit anti-A5-γ-globulin and anti-A4-γ-globulin antisera, respectively. In each case the reactions of the recipients' sera were positive for γ globulin of the donors' allotype but not of their own. Positive reactions were given only by sera above a certain range of agglutinin titre. After sufficient decline of the agglutinin level in the sera of the recipients, these animals were actively immunized with Shigella. The agglutinins that now appeared in these rabbits gave positive reactions with the fluorescent antibody against their own allotype. These data indicated that in moderately X-irradiated rabbits given antigen-incubated rabbit lymph node cells, the antibody that subsequently appears in the recipient's serum has been synthesized by the donor's cells. These experiments also illustrate the use of allotypes as genetic markers in lymph node cell transfer experiments. [ABSTRACT FROM AUTHOR] AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - GAMMA globulins KW - GENETIC markers KW - LYMPH nodes KW - IMMUNOGLOBULIN allotypes KW - IMMUNOGENETICS KW - IMMUNOLOGY N1 - Accession Number: 12673789; Harris, T.N. 1; Dray, Sheldon 1; Ellsworth, Barbara 1; Harris, Susanna 1; Source Information: Mar63, Vol. 6 Issue 2, p169; Subject: GAMMA globulins; Subject: GENETIC markers; Subject: LYMPH nodes; Subject: IMMUNOGLOBULIN allotypes; Subject: IMMUNOGENETICS; Subject: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=12673789&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2013-39667-011 AN - 2013-39667-011 AU - Gorwitz, Kurt AU - Bahn, Anita K. AU - Chandler, Caroline A. AU - Martin, William A. T1 - Planned uses of a statewide psychiatric register for aiding mental health in the community. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/04// VL - 33 IS - 3 SP - 494 EP - 500 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39667-011. Partial author list: First Author & Affiliation: Gorwitz, Kurt; Maryland State Department of Mental Hygiene, Baltimore, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Public Health Services; Treatment Planning. Minor Descriptor: Hospitals; Psychiatric Clinics. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1963. Publication History: Accepted Date: Oct 18, 1962. AB - The traditional pattern of public psychiatric services of previous years is changing. In place of the mental hospital, isolated in function and separated in program planning from other community services, a comprehensive program is emerging. Psychiatric clinics, general hospitals and other newly developed forms of psychiatric service carry an increasing share of the psychiatric responsibility, and a variety of nonpsychiatric community agencies offers important services to, or on behalf of, the mentally ill. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - statewide psychiatric register KW - community mental health services KW - public health services KW - treatment planning KW - general hospitals KW - psychiatric clinics KW - 1963 KW - Community Mental Health Services KW - Public Health Services KW - Treatment Planning KW - Hospitals KW - Psychiatric Clinics KW - 1963 DO - 10.1111/j.1939-0025.1963.tb00383.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39667-011&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39667-015 AN - 2013-39667-015 AU - Stein, Johanna T1 - Music therapy treatment techniques. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/04// VL - 33 IS - 3 SP - 521 EP - 528 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39667-015. Partial author list: First Author & Affiliation: Stein, Johanna; Section on Psychiatry, National Institute of Mental Health, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Music Therapy; Psychotherapy; Rehabilitation; Therapeutic Processes. Minor Descriptor: Hospitalized Patients; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Inpatient (50). Page Count: 8. Issue Publication Date: Apr, 1963. Publication History: Accepted Date: Nov 20, 1962. AB - Work in music was structured so as to intervene in patterns of thought and behavior prohibitive to psychotherapy and rehabilitation of severely disturbed psychiatric inpatients. The course of four patients in music therapy is described to illustrate techniques used and their effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - treatment techniques KW - music therapy KW - psychotherapy KW - rehabilitation KW - psychiatric inpatients KW - 1963 KW - Music Therapy KW - Psychotherapy KW - Rehabilitation KW - Therapeutic Processes KW - Hospitalized Patients KW - Psychiatric Patients KW - 1963 U1 - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated DO - 10.1111/j.1939-0025.1963.tb00387.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39667-015&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Birren, James E. T1 - Research on the psychologic aspects of aging. JO - Geriatrics JF - Geriatrics Y1 - 1963/05// VL - 18 IS - 5 M3 - Article SP - 393 EP - 403 SN - 0016867X N1 - Accession Number: 17145092; Birren, James E. 1; Source Information: May1963, Vol. 18 Issue 5, p393; Number of Pages: 11p; Illustrations: 8 Graphs; Document Type: Article; Full Text Word Count: 3288 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17145092&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Wilkie, Charlotte H. T1 - A Study of Distortions in Recording Interviews. JO - Social Work JF - Social Work Y1 - 1963/07// VL - 8 IS - 3 M3 - Article SP - 31 EP - 36 SN - 00378046 AB - This article explores the nature of the caseworkers' "distortions" in their recording of clients' communications about their problems, attitudes and values. The term distortion is used here in its descriptive sense of change of an original form. The problem of distortions is important because of the struggle to reduce the empirical quality of the worker's every day job and to develop an increasingly scientific basis for it. Recent years have seen many research studies aimed at analyzing the subjective quality of the interviewers perception and observations. The availability of verbatim recording by mechanical means has made this possible and easy. In 1944, Bernard J. Covner, a psychologist, made a study of a number of counseling interviews to analyze the accuracy of the written report as against the phonographic recording. This study was again repeated in 1958 by sociologist C.P. Froelich and yielded very much the same results. In general, a large part of client's interview is not recorded but what is recorded is accurate. According to the study, distortions in communication with clients because of lack of familiarity with deeply pathological patterns of behavior are easier to control as new knowledge of these patterns is acquired. It would be helpful to become aware of those unconscious omissions early in contacts, as they are in the service of workers needs other than the client's. KW - Interviewing KW - Counseling KW - Sound recording & reproducing KW - Communication KW - Attitude (Psychology) KW - Quality KW - Empirical research N1 - Accession Number: 14204596; Wilkie, Charlotte H. 1; Affiliations: 1: Social worker with the Social Service Department, National Institute of Mental Health, Public Health Service,; Issue Info: Jul63, Vol. 8 Issue 3, p31; Thesaurus Term: Interviewing; Thesaurus Term: Counseling; Thesaurus Term: Sound recording & reproducing; Thesaurus Term: Communication; Thesaurus Term: Attitude (Psychology); Subject Term: Quality; Subject Term: Empirical research; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 512240 Sound Recording Studios; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=14204596&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - JOUR ID - 2013-39333-008 AN - 2013-39333-008 AU - Murphey, Elizabeth B. AU - Silber, Earle AU - Coelho, George V. AU - Hamburg, David A. AU - Greenberg, Irwin T1 - Development of autonomy and parent-child interaction in late adolescence. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/07// VL - 33 IS - 4 SP - 643 EP - 652 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39333-008. Partial author list: First Author & Affiliation: Murphey, Elizabeth B.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: College Students; Family; Parent Child Relations. Minor Descriptor: Adolescent Development; Autonomy. Classification: Childrearing & Child Care (2956). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1963. Publication History: Accepted Date: Jan 17, 1962. AB - This study explores the relationship between the capacity for autonomous behavior among freshman college students and the patterns of interaction between the students and their parents during the transition from high school to college. Autonomous-relatedness, the capacity for integration of both independent behavior and the maintenance of positive family ties, appears related to particular transactional family patterns, which were observed. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - autonomous behavior KW - freshman college students KW - parent-child interaction KW - transactional family patterns KW - independent behavior KW - 1963 KW - College Students KW - Family KW - Parent Child Relations KW - Adolescent Development KW - Autonomy KW - 1963 DO - 10.1111/j.1939-0025.1963.tb01012.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39333-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39333-012 AN - 2013-39333-012 AU - Rioch, Margaret J. AU - Elkes, Charmian AU - Flint, Arden A. AU - Usdansky, Blanche Sweet AU - Newman, Ruth G. AU - Silber, Earle T1 - National Institute of Mental Health pilot study in training mental health counselors. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/07// VL - 33 IS - 4 SP - 678 EP - 689 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 AD - Rioch, Margaret J., Adult Psychiatry Branch, National Institute of Mental Health, 14, Bethesda, MD, US N1 - Accession Number: 2013-39333-012. Partial author list: First Author & Affiliation: Rioch, Margaret J.; Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counselors; Mental Health; Mental Health Personnel; Psychotherapy. Classification: Professional Education & Training (3410). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Interview; Quantitative Study. Page Count: 12. Issue Publication Date: Jul, 1963. Publication History: Accepted Date: Feb 8, 1963. AB - The paper describes the first year's work in an experiment to test the hypothesis that carefully selected mature people can be trained within two years to do psychotherapy under limited conditions. Eight 40-year-old married women with children were trained in a very practical program. The results were positive. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health counselors KW - psychotherapy KW - counselor training KW - 1963 KW - Counselors KW - Mental Health KW - Mental Health Personnel KW - Psychotherapy KW - 1963 DO - 10.1111/j.1939-0025.1963.tb01016.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39333-012&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06049-016 AN - 2006-06049-016 AU - Bergman, Paul T1 - The Liberals in Psychoanalysis. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1963/08// VL - 8 IS - 8 SP - 309 EP - 310 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06049-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychoanalysis; Psychoanalytic Theory; Psychoanalytic Training; Social Sciences. Minor Descriptor: Achievement. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Masserman, Jules H. (Ed). Science and Psychoanalysis. Vol. V: Psychoanalytic Education=New York: Grune & Stratton, 1962. Pp. v + 332. $9.75; 1962. Page Count: 2. Issue Publication Date: Aug, 1963. AB - Reviews the book, Science and Psychoanalysis. Vol. V: Psychoanalytic Education edited by Jules H. Masserman (1962). The book contains pleas for biology; social sciences; psychosomatics; communciation processes; flexible therapeutic methods; ward psychiatry; identity problems; value problems; research; alternative theoretical models. The writers present their cases capably, informatively and even convincingly insofar as one cannot reasonably doubt the relevance of these various concerns to the subject matter of psychoanalysis. None of the writers, however, shows how all this material could be integrated into a professional training without intolerably overloading it. Psychoanalytic theory has its own tasks and problems with which the 'liberals' frequently show insufficient acquaintance. They particularly neglect the achievements of ego psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychoanalysis KW - psychoanalytic education KW - psychoanalytic theory KW - professional training KW - ego psychology KW - 1963 KW - Psychoanalysis KW - Psychoanalytic Theory KW - Psychoanalytic Training KW - Social Sciences KW - Achievement KW - 1963 U2 - Masserman, Jules H. (Ed). (1962); Science and Psychoanalysis. Vol. V: Psychoanalytic Education; New York: Grune & Stratton, 1962. Pp. v + 332. $9.75 DO - 10.1037/007306 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06049-016&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06049-017 AN - 2006-06049-017 AU - Bergman, Paul T1 - First Freudians. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1963/08// VL - 8 IS - 8 SP - 310 EP - 311 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06049-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Freud (Sigmund); Psychoanalysis; Psychoanalytic Theory; Society. Minor Descriptor: Evaluation. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Nunberg, Herman (Ed); Federn, Ernst (Ed); Nunberg, M. (Ed). Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908=New York: International Universities Press, 1962. Pp. v + 410. $10.00; 1962. Page Count: 2. Issue Publication Date: Aug, 1963. AB - Reviews the book, Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908 by Herman Nunberg, Ernst Federn and M. Nunberg (1962). The present volume shows the 'professor' presiding in Olympian benevolence, often protecting speakers from too violent attacks, and distinctly favoring those who contributed creatively to the ideas of the circle. Freud's social evaluation of sexuality retains its previous puzzling ambiguity. Whether or not Freud and his followers at times succumbed to self-contradiction, bias and passion, these pages do preserve some great moments in the history of man's spirit. The editors deserve thanks for publishing these minutes and for conscientiously clarifying in footnotes a great many allusions to persons and events which otherwise would remain meaningless. unfortunately they have also added footnotes to expound their own opinions about many of the subjects under discussion, and to stand up for Freud against any doubting or dissenting voice. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychoanalytic society KW - self contradiction KW - Freuds social evaluation KW - psychoanalysis KW - 1963 KW - Freud (Sigmund) KW - Psychoanalysis KW - Psychoanalytic Theory KW - Society KW - Evaluation KW - 1963 U2 - Nunberg, Herman (Ed); Federn, Ernst (Ed); Nunberg, M. (Ed). (1962); Minutes of the Vienna Psychoanalytic Society, Vol. 1: 1906-1908; New York: International Universities Press, 1962. Pp. v + 410. $10.00 DO - 10.1037/007307 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06049-017&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06050-032 AN - 2006-06050-032 AU - Korchin, Sheldon J. T1 - More on Zigler on Witkin. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1963/09// VL - 8 IS - 9 SP - 365 EP - 366 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06050-032. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Korchin, Sheldon J.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Piaget (Jean); Psychological Development. Classification: Developmental Psychology (2800). Population: Human (10). Page Count: 2. Issue Publication Date: Sep, 1963. AB - Comments on Zigler's review (see record [rid]2006-06045-004[/rid]) of Witkin et al 's book Psychological Differentiation: Studies of Development (see record [rid]1963-00819-000[/rid]). The review gives a limited and distorted, as well as generally unsympathetic, picture of the purposes, methods, findings and theoretical position of what is a major contribution of a vigorous and dedicated research group. The reviewer is critical of the authors' theoretical effort ('which promises so much and delivers so little') but nowhere is the differentiation hypothesis described, nor is there mention of the supplementary constructs--the sense of separate identity, defined body concepts, specialized defenses, etc.--important to the understanding of reviewer's view. The judgment that differentiation reduces to decontextualization in reviewer's usage, and that this brings it into conflict with the work of Werner and Piaget, is unjustified. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychological differentiation KW - psychological development KW - 1963 KW - Piaget (Jean) KW - Psychological Development KW - 1963 DO - 10.1037/007346 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06050-032&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - AU - Bower, Eli M.1 T1 - Mental Health and Education: A Play in Three Acts. JO - Educational Leadership JF - Educational Leadership J1 - Educational Leadership PY - 1963/10// Y1 - 1963/10// VL - 21 IS - 1 CP - 1 M3 - Article SP - 8 EP - 63 SN - 00131784 AB - The article discusses developments of the education and mental health in the 20th century. The first State Mental Health Association was started in Connecticut in 1908. A series of meetings to plan a child guidance clinic for juvenile offenders was held in Chicago by Dr. William Healy. In 1908, Dr. Henry Goddard at the Vineland school in New Jersey started to use a new mechanical scale to assess the mental age of children. The scale was devised by Drs. Binet and Simon. In the same year the number of clinics, family service agencies, welfare departments and other community agencies increased. In 1920 a five year program for the prevention of juvenile delinquency was launched with the help of the Commonwealth Fund and the National Committee for Mental Hygiene. Meanwhile health personnel renew their strategy of help to cure the problem of juvenile delinquents. KW - Education KW - Child mental health services KW - Juvenile delinquents -- Health KW - Problem children KW - Health facilities KW - Educational counseling KW - Mental age KW - Mental health KW - Physicians N1 - Accession Number: 21641394; Authors: Bower, Eli M. 1; Affiliations: 1: Consultant, Mental Health in Education, National Institute of Mental Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland.; Subject: Child mental health services; Subject: Education; Subject: Juvenile delinquents -- Health; Subject: Problem children; Subject: Health facilities; Subject: Educational counseling; Subject: Mental age; Subject: Mental health; Subject: Physicians; Number of Pages: 4p; Record Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=21641394&site=ehost-live&scope=site DP - EBSCOhost DB - lls ER - TY - JOUR ID - 2013-39342-003 AN - 2013-39342-003 AU - Forstenzer, Hyman M. AU - Felix, Robert H. T1 - Community mental health—1963 symposium: 1. Community mental health. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/10// VL - 33 IS - 5 SP - 788 EP - 795 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39342-003. Partial author list: First Author & Affiliation: Forstenzer, Hyman M.; New York State Department of Mental Hygiene, Albany, NY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health; Knowledge (General); Interpersonal Control. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 8. Issue Publication Date: Oct, 1963. Publication History: Accepted Date: Jul 5, 1963. AB - Success of the National Mental Health Program proposed by President Kennedy hinges on public acceptance of the comprehensive Community Mental Health Center concept of care for the mentally ill; on coordinated and adequate planning; on proper recruitment and utilization of manpower; and on an expanded and intensified search for new knowledge and techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - community mental health KW - public acceptance KW - manpower KW - knowledge KW - 1963 KW - Community Mental Health KW - Knowledge (General) KW - Interpersonal Control KW - 1963 DO - 10.1111/j.1939-0025.1963.tb01040.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39342-003&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39342-009 AN - 2013-39342-009 AU - Bower, Eli M. T1 - Primary prevention of mental and emotional disorders: A conceptual framework and action possibilities. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1963/10// VL - 33 IS - 5 SP - 832 EP - 848 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 AD - Bower, Eli M., Research Utilization Branch, National Institute of Mental Health, 14, Bethesda, MD, US N1 - Accession Number: 2013-39342-009. Partial author list: First Author & Affiliation: Bower, Eli M.; Research Utilization Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Disturbances. Minor Descriptor: Concept Formation; Primary Mental Health Prevention; Psychologists. Classification: Psychological & Physical Disorders (3200). Population: Human (10). References Available: Y. Page Count: 17. Issue Publication Date: Oct, 1963. Publication History: Accepted Date: Jun 6, 1961. AB - Prevention is seen as a magic word that has had little action implementation in the field of mental and emotional disorders. Moreover, lay and professional groups appear to have a desultory defeatist attitude toward such activity. In part, this is the result of an inability to conceptualize a usable and meaningful theoretical structure from which research and demonstration programs can be developed. A conceptualization of primary prevention and programs of research and demonstration are presented and discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - conceptual framework KW - emotional disorders KW - primary prevention KW - professional groups KW - 1963 KW - Emotional Disturbances KW - Concept Formation KW - Primary Mental Health Prevention KW - Psychologists KW - 1963 DO - 10.1111/j.1939-0025.1963.tb01046.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39342-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - CHAP ID - 2007-11837-002 AN - 2007-11837-002 AU - Basowitz, Harold AU - Speisman, Joseph C. ED - Blank, Leonard ED - David, Henry P. ED - Blank, Leonard, (Ed) ED - David, Henry P., (Ed) T1 - Program support for training by the National Institute of Mental Health: 1947-1963. T2 - Sourcebook for training in clinical psychology. Y1 - 1964/// SP - 43 EP - 60 CY - New York, NY, US PB - Springer Publishing Co N1 - Accession Number: 2007-11837-002. Partial author list: First Author & Affiliation: Basowitz, Harold; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20070806. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Handbook/Manual. Language: English. Major Descriptor: Experimentation; Mental Health; Mental Health Programs; Psychology; Training. Minor Descriptor: Funding; Personnel Supply; Public Health. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 18. AB - The National Institute of Mental Health (NIMH) is one of nine organizational units which in the aggregate comprise the National Institutes of Health and serve as the principal research arm of the United States Public Health Service (USPHS). The NIMH was established as a consequence of Congressional action in 1946. Its mandate is to improve the mental health of the nation. Four basic functions are involved: 1) the conduct of research into the etiology, diagnosis, treatment and prevention of mental illness; 2) assistance and support of such research activities by universities, medical schools and other public and private agencies; 3) consultation, technical services and grants to states and communities to aid in the development of comprehensive mental health programs; and 4) support of mental health manpower training for research and service. The present chapter deals with the last of these four functions--training--as it bears particularly upon the field of psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - comprehensive mental health programs KW - program support KW - research KW - consultation KW - technical services KW - grants KW - mental health manpower KW - mental health training KW - psychology KW - 1964 KW - Experimentation KW - Mental Health KW - Mental Health Programs KW - Psychology KW - Training KW - Funding KW - Personnel Supply KW - Public Health KW - 1964 DO - 10.1037/11535-002 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11837-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2011-17083-002 AN - 2011-17083-002 AU - Bower, Eli M. T1 - Psychology in the schools: Conceptions, processes and territories. JF - Psychology in the Schools JO - Psychology in the Schools JA - Psychol Sch Y1 - 1964/01// VL - 1 IS - 1 SP - 3 EP - 11 CY - US PB - John Wiley & Sons SN - 0033-3085 SN - 1520-6807 N1 - Accession Number: 2011-17083-002. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, United Kingdom. Release Date: 20120312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Education; Psychologists; Schools. Classification: Educational Psychology (3500). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 9. Issue Publication Date: Jan, 1964. AB - In order to make human beings out of potential human beings, human societies have created institutions such as families and schools. The nature and specific processes by which these institutions carry out their purposes vary with the kind of human qualities espoused in each society. The purpose of this issue in our society is to produce emotionally free, cognitively effective human beings. As psychologists are concerned with the impact of cognitive-affective experiences in producing this kind of human being; as professional practitioners, psychologists are concerned with contributing their knowledge and skills to educators so that relevant behavioral science knowledge and experience can be transmitted and utilized by the educational institutions and their staffs. There is an inexcusable snobbery about educational processes which reflects a lack of conviction about the psychological and transactional properties of learning. The fact that differences between and among people necessitate qualitative differences in educational content and process does not mean such differences must have lesser or greater value or significance as a human experience. Psychologists and educators need to promote differences among and between educational experiences while at the same time enhancing the value of each as a meaningful transaction to the child and to society. It was suggested earlier that going to school was for children and adolescents what going to work was for adults. The greatest stumbling block however for educators and psychologists lies in the perception of their own job. Professional competency and leadership lie not so much in doing one’s job well but in understanding the primary purpose of what one is doing and its place in the scheme of things. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychologists KW - cognitive experiences KW - educational content KW - schools KW - 1964 KW - Cognitive Processes KW - Education KW - Psychologists KW - Schools KW - 1964 DO - 10.1002/1520-6807(196401)1:1<3::AID-PITS2310010102>3.0.CO;2-P UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-17083-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Ball, John C. AU - Ross, Alan AU - Simpson, Alice T1 - INCIDENCE AND ESTIMATED PREVALENCE OF RECORDED DELINQUENCY IN A METROPOLITAN AREA. JO - American Sociological Review JF - American Sociological Review Y1 - 1964/02// VL - 29 IS - 1 M3 - Article SP - 90 EP - 93 SN - 00031224 AB - Juvenile court data from Fayette County, Kentucky, a metropolitan area, were used to compute the incidence and prevalent rates of delinquency for 1960. The incidence varies markedly with age and sex, the highest being among 17-year-old boys. The outcome of the study is a new procedure for estimating the prevalence of delinquency in a given population. 7 notes, 2 tables. KW - JUVENILE delinquency KW - CONDUCT disorders in children KW - JUVENILE courts KW - LARCENY KW - CRIMINAL courts KW - FAYETTE County (Ky.) KW - KENTUCKY KW - UNITED States KW - Kentucky (Fayette County) N1 - Accession Number: 12766726; Ball, John C. 1; Ross, Alan 2; Simpson, Alice 2; Affiliations: 1 : National Institute of Mental Health Lexington, Kentucky.; 2 : University of Kentucky.; Source Info: Feb64, Vol. 29 Issue 1, p90; Historical Period: 1960; Subject Term: JUVENILE delinquency; Subject Term: CONDUCT disorders in children; Subject Term: JUVENILE courts; Subject Term: LARCENY; Subject Term: CRIMINAL courts; Subject: FAYETTE County (Ky.); Subject: KENTUCKY; Subject: UNITED States; Number of Pages: 4p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=12766726&site=ehost-live&scope=site DP - EBSCOhost DB - ahl ER - TY - JOUR AU - Ruhl, Mary Jane T1 - Chemical Documents and their Titles: Human Concept Indexing vs. KWlC-Machine Indexing. JO - American Documentation JF - American Documentation Y1 - 1964/04// VL - 15 IS - 2 M3 - Article SP - 136 EP - 141 SN - 0096946X AB - The machine-produced, key-word-in-context title index was introduced as a temporary bridge between current literature and its indexes. Due to the lower cost and more rapid production, some researchers might substitute these indexes for the conventional ones, but valuable research findings might be lost if titles omit important descriptive words. Comparing the indexing of the same documents in Chemical Titles and Chemical Abstracts Subject Index shows that more than half of the titles included all concepts, or their equivalents, as indexed by Chemical Abstracts. However, in many cases, more definitive titles might have been assigned to the documents. Authors and editors must continue to upgrade their titles by examining each title word. Does each word define some aspect of the report? Have words been included in the title to describe, as nearly as possible, each important new development reported? [ABSTRACT FROM AUTHOR] AB - Copyright of American Documentation is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - INDEXES KW - DOCUMENTATION KW - LITERATURE KW - ABSTRACTS KW - DESCRIPTIVE cataloging KW - INDEXING N1 - Accession Number: 16778390; Ruhl, Mary Jane 1,2; Affiliations: 1: Biological Sciences Communication Project, George Washington University, Washington 6, D. C.; 2: American Rheumatism Association, Literature Analysis Project, National Institutes of Health, Bethesda, Maryland.; Issue Info: Apr1964, Vol. 15 Issue 2, p136; Thesaurus Term: INDEXES; Thesaurus Term: DOCUMENTATION; Subject Term: LITERATURE; Subject Term: ABSTRACTS; Subject Term: DESCRIPTIVE cataloging; Subject Term: INDEXING; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16778390&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Erlich, Howard J. T1 - These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations. JO - Sociological Quarterly JF - Sociological Quarterly Y1 - 1964///Spring64 VL - 5 IS - 2 M3 - Book Review SP - 177 EP - 178 SN - 00380253 AB - Reviews the book "These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations," by Jacqueline J. Clarke. KW - CIVIL rights organizations KW - NONFICTION KW - CLARKE, Jacqueline J. KW - THESE Rights They Seek (Book) N1 - Accession Number: 14021169; Erlich, Howard J. 1; Affiliations: 1 : National Institute of Mental Health; Source Info: Spring64, Vol. 5 Issue 2, p177; Subject Term: CIVIL rights organizations; Subject Term: NONFICTION; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=14021169&site=ehost-live&scope=site DP - EBSCOhost DB - 24h ER - TY - JOUR ID - 2011-17084-008 AN - 2011-17084-008 AU - Gladwin, Thomas T1 - The school, society, and the child. JF - Psychology in the Schools JO - Psychology in the Schools JA - Psychol Sch Y1 - 1964/04// VL - 1 IS - 2 SP - 162 EP - 173 CY - US PB - John Wiley & Sons SN - 0033-3085 SN - 1520-6807 N1 - Accession Number: 2011-17084-008. Partial author list: First Author & Affiliation: Gladwin, Thomas; National Institute of Mental Health, US. Release Date: 20120312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Childhood Development; Education; Schools; Society. Classification: Educational Psychology (3500). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1964. AB - The school is obviously a part of our total culture. It is not only caught in the conflicts of the larger society, but also necessarily itself contributes to the inconsistencies with which the child is faced. The child is expected to develop confidence and self-assurance. The pressures we exert are not only strong but are also frequently so contradictory that the child cannot by himself resolve them. The fact that school contributes to these conflicts and pressures is certainly not new to educators. Some of the more radical attempts to counter or eliminate pressures on children have illustrated the difficulties involved. The educational system is an instrument of the larger society. The social skills and perceptiveness of a child also change markedly as he grows up. A wide variety of factors could be considered with respect to the continuity between in-school and out-of-school experience. The ability of teachers to react immediately and perceptively to subtle emotional responses in their students has an important bearing on the number of students with whom they can develop a constructive social relationship. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - schools KW - societies KW - childhood development KW - education KW - 1964 KW - Childhood Development KW - Education KW - Schools KW - Society KW - 1964 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-17084-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06058-020 AN - 2006-06058-020 AU - Bergman, Paul T1 - 'And a time to laugh.' JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1964/05// VL - 9 IS - 5 SP - 219 EP - 220 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06058-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bergman, Paul; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Jokes; Laughter; Psychoanalysis; Unconscious (Personality Factor). Minor Descriptor: Hate Crimes. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Freud, Sigmund; Strachey, James (Ed). Jokes and their Relation to the Unconscious=New York: W. W. Norton & Co., 1963. Pp. 258. $1.45; 1963. Page Count: 2. Issue Publication Date: May, 1964. AB - Reviews the book, Jokes and their Relation to the Unconscious by Sigmund Freud (edited and translated by James Strachey) (see record [rid]1964-02765-000[/rid]). Freud wrote the present book in 1905, but the new translation, done by Strachey for the Standard Edition of the Complete Works, reveals for the first time in English the charm of the work, unencumbered by the clumsiness of the earlier version. Here one can see Freud's superb patience in focusing on detail and his amazing power of organization as he places detail in the context of his view of man. Freud's own greatness repeatedly manifests itself; also that at times it is hard to decide whether or not an expression of his basic attitude is intentional. Jokes are a simple, objectively available material not embedded in a complex living organism. A dubious beginning, a stupendous second phase, an abortive ending, this is the conception of the typical course of Freud's thought. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - jokes KW - unconscious KW - laugh KW - 1964 KW - Jokes KW - Laughter KW - Psychoanalysis KW - Unconscious (Personality Factor) KW - Hate Crimes KW - 1964 U2 - Freud, Sigmund; Strachey, James (Ed). (1963); Jokes and their Relation to the Unconscious; New York: W. W. Norton & Co., 1963. Pp. 258. $1.45 DO - 10.1037/007558 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06058-020&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Duhl, Leonard J. T1 - A Mental Health Program for the Peace Corps. JO - Human Organization JF - Human Organization Y1 - 1964///Summer64 VL - 23 IS - 2 M3 - Article SP - 131 EP - 136 SN - 00187259 AB - Describes the mental health program of the Peace Corps; its role in the selection of volunteers, assistance to volunteers during their tour of duty, and its assistance on reentry into American culture. 11 notes. KW - MENTAL health facilities KW - PSYCHOLOGISTS KW - COMMUNITY mental health services KW - HEALTH promotion KW - SOCIAL systems KW - MEDICAL corporations KW - MENTAL health services KW - MENTAL health KW - UNITED States KW - PEACE Corps (U.S.) N1 - Accession Number: 26909689; Duhl, Leonard J. 1,2,3; Affiliations: 1 : Psychiatrist, Professional Services Branch, National Institute of Mental Health, George Washington University, Washington, D.C.; 2 : NIMH-Peace Corps Liaison Representative and Consultant in Psychiatry, George Washington University, Washington, D.C.; 3 : Clinical Assistant Professor in Psychiatry, George Washington University, Washington, D.C.; Source Info: Summer64, Vol. 23 Issue 2, p131; Historical Period: 1962; Subject Term: MENTAL health facilities; Subject Term: PSYCHOLOGISTS; Subject Term: COMMUNITY mental health services; Subject Term: HEALTH promotion; Subject Term: SOCIAL systems; Subject Term: MEDICAL corporations; Subject Term: MENTAL health services; Subject Term: MENTAL health; Subject: UNITED States; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=26909689&site=ehost-live&scope=site DP - EBSCOhost DB - ahl ER - TY - JOUR ID - 2006-06059-014 AN - 2006-06059-014 AU - Rheingold, Harriet L. T1 - Descriptively psychiatric. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1964/06// VL - 9 IS - 6 SP - 261 EP - 262 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06059-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rheingold, Harriet L.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childrearing Practices; Developmental Psychology; Infant Development; Institutionalization; Psychometrics. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Provence, Sally; Lipton, Rose C. Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life=New York: International Universities Press, 1962. Pp. v + 191. $5.00; 1962. Page Count: 2. Issue Publication Date: Jun, 1964. AB - Reviews the book, Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life by Sally Provence and Rose C. Lipton (see record [rid]1963-07862-000[/rid]). This study finds that infants in an institution do more poorly, by the criteria of comparison chosen, than an equal number of home babies. The infants were given psychological tests; although the authors refer to the tests in making their judgments, they do not present the results since their data, 'interpreted statistically, do not reveal new findings.' Little is revealed about the selection of the infants. Infants in instiutions do not really provide one of Nature's experiments because differences observed between groups of home and institutionalized infants cannot be interpreted as caused solely by the differences in the environment. This book's contribution lies in its carefully detailed account of infant behavior and environment. Certainly no one will quarrel with the authors' plea for improving infant care in poor institutions. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychological tests KW - institutionalized infants KW - infant behavior KW - family reared infants KW - nfant development KW - 1964 KW - Childrearing Practices KW - Developmental Psychology KW - Infant Development KW - Institutionalization KW - Psychometrics KW - 1964 U2 - Provence, Sally; Lipton, Rose C. (1962); Infants in Institutions: A Comparison of Their Development with Family-Reared Infants During the First Year of Life; New York: International Universities Press, 1962. Pp. v + 191. $5.00 DO - 10.1037/007588 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06059-014&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Legler, Jean F. AU - Benchimol, Alberto T1 - The significance of extrasystoles in coronary artery disease. JO - Geriatrics JF - Geriatrics Y1 - 1964/07// VL - 19 IS - 7 M3 - Article SP - 468 EP - 475 SN - 0016867X N1 - Accession Number: 17107674; Legler, Jean F. 1; Benchimol, Alberto 2; Source Information: Jul1964, Vol. 19 Issue 7, p468; Number of Pages: 8p; Illustrations: 8 Diagrams; Document Type: Article; Full Text Word Count: 2547 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17107674&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2011-17085-008 AN - 2011-17085-008 AU - Duhl, Leonard J. T1 - Crises, adaptive potential and the school. JF - Psychology in the Schools JO - Psychology in the Schools JA - Psychol Sch Y1 - 1964/07// VL - 1 IS - 3 SP - 263 EP - 266 CY - US PB - John Wiley & Sons SN - 0033-3085 SN - 1520-6807 N1 - Accession Number: 2011-17085-008. Partial author list: First Author & Affiliation: Duhl, Leonard J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20120326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Attention; Childhood Development; Crises. Minor Descriptor: Schools. Classification: Cognitive & Perceptual Development (2820). Population: Human (10). Page Count: 4. Issue Publication Date: Jul, 1964. AB - If one is concerned with the normal development of children, one cannot help but focus attention on the school. The school claims the time, attention and concerns of the child for a major period of the child’s life. There have been many ways of looking at the school and its impact on children. This article concentrates on one approach rather than review all the studies in this field dealing with this experience. This concentration results from the belief that this approach arising from the work in preventive community mental health may be equally relevant to the field of education. There has been no attempt in this paper to present a comprehensive model of the school or of human development. It is hoped that the concepts so briefly outlined above can be understood more fully. There have been some school programs that have been indeed using this model effectively in understanding themselves. The schools in fact are in crises, and the choice of responses to these crises can lead both to danger and to opportunity for child, school and society. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - childhood development KW - crises KW - attention KW - school KW - 1964 KW - Attention KW - Childhood Development KW - Crises KW - Schools KW - 1964 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-17085-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06060-006 AN - 2006-06060-006 AU - Blank, Paul T1 - On states and acts. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1964/07// VL - 9 IS - 7 SP - 281 EP - 282 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06060-006. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Blank, Paul; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Nature; Love; Motivation; Needs. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Reik, Theodor. The Need to be Loved=New York: Farrar, Straus and Co., 1963. Pp. 276. $4.95; 1963. Page Count: 2. Issue Publication Date: Jul, 1964. AB - Reviews the book, The Need to be Loved by Theodor Reik (1963). Through most of Reik's commentaries run the hopes, fantasies, sorrows, illusions and paradoxes of human nature; a spectacle with large reflections about behavior as viewed through a prism constructed out of crystal clear drives and instincts. It would take many evenings indeed to recount the book's three hundred and twenty-three commentaries whose topics, numbered and titled, range far and wide and whose relevance to the subject of the book is not immediately apparent. Instead, too many sayings in the book are contrived and banal, substituting literary platitudes for profundities. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - needs KW - loved KW - drives KW - instincts KW - 1964 KW - Human Nature KW - Love KW - Motivation KW - Needs KW - 1964 U2 - Reik, Theodor. (1963); The Need to be Loved; New York: Farrar, Straus and Co., 1963. Pp. 276. $4.95 DO - 10.1037/007605 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06060-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06060-009 AN - 2006-06060-009 AU - Bower, Eli M. T1 - Growing pains. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1964/07// VL - 9 IS - 7 SP - 284 EP - 285 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06060-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Professional Development; School Psychology; Teaching. Classification: Educational Psychology (3500). Population: Human (10). Reviewed Item: Gottsegen, Monroe G. (Ed); Gottsegen, Gloria B. (Ed). Professional School Psychology. Vol. II=New York: Grune and Stratton, 1963. Pp. iii + 354. $9.75; 1963. Page Count: 2. Issue Publication Date: Jul, 1964. AB - Reviews the book, Professional School Psychology. Vol. II edited by Monroe G. Gottsegen and Gloria B. Gottsegen (see record [rid]1964-04646-000[/rid]). The Gottsegens have made a start in getting a number of knowledgeable and imaginative 'parents' to identify the specific areas in the infant where growth and development are taking place. Each of the contributors presents his material clearly and concisely with only occasional lapses into dullness and discussion of the obvious. Several contributors are concerned with psychotherapy in school and graciously minimize the hoary debate on whether this function is relevant for this profession. The teaching of psychology is brought into the picture as well as research in curriculum. All in all one gets a savory and tasty spread of topics but I'm afraid the nature of the menu still remains largely in the eye of the beholder. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - professional school psychology KW - curriculum KW - teaching KW - developmental psychology KW - 1964 KW - Curriculum KW - Professional Development KW - School Psychology KW - Teaching KW - 1964 U2 - Gottsegen, Monroe G. (Ed); Gottsegen, Gloria B. (Ed). (1963); Professional School Psychology. Vol. II; New York: Grune and Stratton, 1963. Pp. iii + 354. $9.75 DO - 10.1037/007608 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06060-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-40691-009 AN - 2013-40691-009 AU - Bower, Eli M. T1 - The modification, mediation and utilization of stress during the school years. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1964/07// VL - 34 IS - 4 SP - 667 EP - 674 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-40691-009. Partial author list: First Author & Affiliation: Bower, Eli M.; Research Utilization Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Modification; Classrooms. Minor Descriptor: Crises; Mediation; School Environment; Stress; Students. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1964. Publication History: Accepted Date: Jan 2, 1964. AB - A n analysis of peaks of normal crises that can be anticipated for school-age children, and some possibilities for managing these crises so that the child becomes a more effective learner, are presented. By establishing barriers at strategic and visible points of crisis (school entrance, birth of sibling, third grade), schools can assist children to build stress immunity. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - behavior modification KW - mediation KW - utilization KW - stress KW - school years KW - 1964 KW - Behavior Modification KW - Classrooms KW - Crises KW - Mediation KW - School Environment KW - Stress KW - Students KW - 1964 DO - 10.1111/j.1939-0025.1964.tb02367.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40691-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06061-006 AN - 2006-06061-006 AU - Tiedeman, David V. T1 - A potpourri of talent and schools. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1964/08// VL - 9 IS - 8 SP - 312 EP - 313 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06061-006. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tiedeman, David V.; National Institute of Mental Health, US. Release Date: 20061023. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Ability; Gifted; High School Education; Secondary Education. Classification: Gifted & Talented (3575). Population: Human (10). Reviewed Item: Flanagan, John C.; Dailey, John T.; Shaycoft, Marion F.; Orr, David B.; Goldberg, Isadore. Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School=Pittsburgh, Pa.: University of Pittsburgh, 1962; 1962. Page Count: 2. Issue Publication Date: Aug, 1964. AB - Reviews the book, Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School by John C. Flanagan, John T. Dailey, Marion F. Shaycoft, David B. Orr, and Isadore Goldberg (1962). The report deals primarily with the organization and setting of secondary education in some relation to the aptitude and achievement of the pupils. The first general issue is the adoption of a taxonomy of a few classes which effectively carries the evident heterogeneity among the statistical series under study. The second general issue is the effect of community and school organization upon the achievement of pupils. The reviewer believes that this volume is neither a census nor an integrated report of the investigation of adequately circumscribed problems. The reviewer believes that the authors can make more lasting contributions in future reports of Project Talent by publishing a census before they engage alone in research on census-like data which are of such import both to the public and to those who make their livelihood in education. Whatever the cause of seeming ambiguity, it should be understood that, despite difficulty, the present report provides aspects of a benchmark deserving of wide reference. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - talents KW - secondary education KW - educational plans KW - aptitude patterns KW - American high school KW - 1964 KW - Ability KW - Gifted KW - High School Education KW - Secondary Education KW - 1964 U2 - Flanagan, John C.; Dailey, John T.; Shaycoft, Marion F.; Orr, David B.; Goldberg, Isadore. (1962); Project Talent: A Survey and Follow-up Study of Educational Plans and Decisions in Relation to Aptitude Patterns: Studies of the American High School; Pittsburgh, Pa.: University of Pittsburgh, 1962 DO - 10.1037/007629 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06061-006&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2005-10157-001 AN - 2005-10157-001 AU - Schneider, Stanley F. T1 - Some comments on 'Congenital insensitivity to pain: A critique.' JF - Psychological Bulletin JO - Psychological Bulletin JA - Psychol Bull Y1 - 1964/10// VL - 62 IS - 4 SP - 287 EP - 288 CY - US PB - American Psychological Association SN - 0033-2909 SN - 1939-1455 N1 - Accession Number: 2005-10157-001. Partial author list: First Author & Affiliation: Schneider, Stanley F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Congenital Disorders; Pain; Pain Perception. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 1964. Copyright Statement: American Psychological Association. 1964. AB - A note on the paper by R. A. Sternbach (see record [rid]1963-07503-001[/rid]) to correct the statement attributed to this author (S. F. Schneider) that the latter considers the syndrome of indifference to pain a defense mechanism, which, in fact, was not the case. A distinction is made between syndrome and defense. A summary of the neuropathologic findings on one of Schneider's cases is presented. Since these findings were equivocal in pathologic significance and thus inconclusive, an explanation of the anomaly on the basis of neural deficit remains as hypothetical as those based upon psychological factors. Sternbach's concluding generalization that pain is not a necessary component in normal personality development is felt to be premature, since the evidence is hardly adequate at this time to describe how the absence of pain may effect personality. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - pain KW - congenital insensitivity KW - 1964 KW - Congenital Disorders KW - Pain KW - Pain Perception KW - 1964 DO - 10.1037/h0038461 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10157-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39344-005 AN - 2013-39344-005 AU - Brown, Bertram S. AU - Cain, Harry P. II T1 - The many meanings of 'comprehensive.' JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1964/10// VL - 34 IS - 5 SP - 834 EP - 839 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39344-005. Partial author list: First Author & Affiliation: Brown, Bertram S.; Community Mental Health Facilities Branch, National Institute of Mental Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Mental Health; Quality of Services. Minor Descriptor: Community Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 6. Issue Publication Date: Oct, 1964. Publication History: Accepted Date: Jun 15, 1964. AB - 'Comprehensive,' when used to describe a community mental health center, has many meanings. They extend from reference to the range of services available and the variety of people served to reflections of the efforts and the kinds of planning needed to make a comprehensive center a reality. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - community mental health KW - comprehensive center KW - mental health center KW - service quality KW - 1964 KW - Community Mental Health Services KW - Mental Health KW - Quality of Services KW - Community Services KW - 1964 DO - 10.1111/j.1939-0025.1964.tb02238.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39344-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39344-018 AN - 2013-39344-018 AU - O'Donnell, John A. T1 - A follow-up of narcotic addicts: Mortality, relapse and abstinence. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1964/10// VL - 34 IS - 5 SP - 948 EP - 954 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39344-018. Partial author list: First Author & Affiliation: O'Donnell, John A.; Social Science Section, Addiction Research Center, National Institute of Mental Health, Lexington, KY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20170213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Health Care Services; Hospitals; Narcotic Drugs. Minor Descriptor: Public Health. Classification: Substance Abuse & Addiction (3233); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Field Study; Interview; Quantitative Study. Page Count: 7. Issue Publication Date: Oct, 1964. Publication History: Accepted Date: Jun 11, 1964. AB - Kentucky residents who were treated for narcotic addiction at the U. S. Public Health Service Hospital, Lexington, Kentucky, between May, 1935 and December, 1959, were followed to determine what happened to them after discharge. Sample size was 266. More than half had died. Of living subjects, more than half were abstinent from narcotics when located. (PsycINFO Database Record (c) 2017 APA, all rights reserved) KW - narcotic addicts KW - mortality KW - sample size KW - hospitals KW - public health KW - health services KW - 1964 KW - Drug Addiction KW - Health Care Services KW - Hospitals KW - Narcotic Drugs KW - Public Health KW - 1964 U1 - Sponsor: National Institutes of Health, US. Grant: M4014. Recipients: No recipient indicated DO - 10.1111/j.1939-0025.1964.tb02251.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39344-018&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Goldsmith, Harold F. AU - Copp, James H. T1 - Metropolitan Dominance and Agriculture. JO - Rural Sociology JF - Rural Sociology Y1 - 1964/12//12/1/64 VL - 29 IS - 4 M3 - Article SP - 385 EP - 395 SN - 00360112 AB - Hypothesizes that agriculture tends to be spatially organized with respect to urban centers. Thus, the level of urbanization and proximity to cities will largely determine land values in a given area. This factor is noted for the Northeastern United States. Some deviation exists where small cities are close to large SMSA's. One of the principles realized here is that, as the size of the largest urban place (city or otherwise) increases, the average value of land and buildings per acre increases. Based on a study of the 299 counties of the Northeastern United States; 2 tables, 14 notes. KW - METROPOLITAN areas KW - AGRICULTURE KW - URBANIZATION KW - SOCIAL history KW - URBAN policy KW - UNITED States KW - Land values N1 - Accession Number: 13249449; Goldsmith, Harold F. 1; Copp, James H. 2; Affiliations: 1 : Project Director, Mental Health Study Center, National Institute of Mental Health.; 2 : Associate Professor of Rural Sociology, The Pennsylvania State University, University Park, Pennsylvania.; Source Info: 12/1/64, Vol. 29 Issue 4, p385; Historical Period: 1964; Subject Term: METROPOLITAN areas; Subject Term: AGRICULTURE; Subject Term: URBANIZATION; Subject Term: SOCIAL history; Subject Term: URBAN policy; Subject: UNITED States; Number of Pages: 11p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=13249449&site=ehost-live&scope=site DP - EBSCOhost DB - ahl ER - TY - JOUR AU - Alderman, Michael H. T1 - JO - New Republic JF - New Republic J1 - New Republic PY - 1964/12/26/ Y1 - 1964/12/26/ VL - 151 IS - 26 M3 - Article SP - 17 EP - 20 SN - 00286583 AB - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964. Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare. KW - MEDICAL care -- United States KW - MEDICAL care for the aged KW - SOCIAL security -- Law & legislation KW - MEDICARE KW - HEALTH insurance -- United States KW - UNITED States N1 - Accession Number: 10013939; Source Information: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 4p; ; Document Type: Article; UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=mth&AN=10013939&site=ehost-live&scope=site DP - EBSCOhost DB - mth ER - TY - Gen ID - 9999-06327-000 AN - 9999-06327-000 AU - Schaefer, Earl S. T1 - Children's Reports of Parental Behavior Inventory JF - PsycTESTS JO - PsycTESTS Y1 - 1965/// AD - Schaefer, Earl S., National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland, United States, 20014 AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No N1 - Accession Number: 9999-06327-000. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111107. Correction Date: 20120409. Instrument Type: Inventory/Questionnaire. Test Format: Items are rated on a three-point Likert-type scale.. Language: English. Constructs: Parental Behavior; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). N2 - Administration Method: Paper AB - Purpose: The purpose of the Children's Reports of Parental Behavior Inventory is to collect and assess child perceptions of parental behavior. AB - Description: The Children's Reports of Parental Behavior Inventory (Schaefer, 1965) was developed through a selection of parental-behavior concepts guided by a conceptual model that had been developed from factor analyses of psychologists' ratings of parental behavior. Similar dimensions of authoritarian control and hostile rejection were found in factor analyses of parental-attitude scales. A review of conceptual models for parental behavior also revealed substantial agreement among two-dimensional models that have been independently developed. These conceptual models led to the formulation of a hierarchical conceptual scheme for parental behavior. Four molar dimensions were identified: Autonomy, Love, Control, and Hostility. Several combinations of these dimensions were used to form the concepts measured. Approximately 20 items were written for each concept. Each of three psychologists made a global evaluation of the 20 items for each concept on a three-point scale. A 10-item scale was then developed for each of the 26 concepts from those items which received the highest ratings. The scales were administered to a sample of 7th grade children and a sample of institutionalized delinquent boys. Internal consistency reliabilities were sufficiently high and the scales demonstrated evidence of discriminative validity. (PsycTESTS Database Record (c) 2014 APA, all rights reserved) KW - Children's Reports of Parental Behavior Inventory KW - Parent Child Relations KW - Child Attitudes KW - Attitude Measures KW - Test Development KW - Internal Consistency KW - Test Validity U5 - Children's Reports of Parental Behavior Inventory [Test Development]Children's reports of parental behavior: An inventory. (AN: 1965-12269-001 from PsycINFO) Schaefer, Earl S.; 1965. Source: Child Development. 36(2), Blackwell Publishing, United Kingdom; 1965; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Samples: Normal 7th Grade Boys and Girls (Aged 12 to 14 Years) and Institutionalized Delinquent Boys (Aged 12 to 18 Years) Keywords: Children's Reports of Parental Behavior Inventory; Parent Child Relations; Child Attitudes; Attitude Measures; Test Development; Internal Consistency; Test Validity; Subjects: Attitude Measures; Child Attitudes; Parent Child Relations; Parental Characteristics; Test Construction; Test Reliability; Test Validity; DO - 10.1037/t06327-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-06327-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - Gen ID - 9999-07373-000 AN - 9999-07373-000 AU - Haertzen, Charles A. T1 - Addiction Research Center Inventory: General Drug Control- Estimation Scale JF - PsycTESTS JO - PsycTESTS Y1 - 1965/// AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No N1 - Accession Number: 9999-07373-000. Acronyms: ARCI-DE. Partial author list: First Author & Affiliation: Haertzen, Charles A.; National Institute of Mental Health Addiction Research Center, Lexington, Kentucky, United States. Release Date: 20130107. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: The response format for this scale is true-false.. Language: English. Constructs: Drug Control Estimation; Classification: Addiction, Gambling, and Substance Abuse/Use (5000). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). N2 - Administration Method: Paper AB - Purpose: The ARCI-DE scale is a general drug control-estimator scale that could be used with empirical drug scales to show whether any particular subject is affected by or under the influence of a psychologically active drug. AB - Description: The Addiction Research Center Inventory (ARCI) is a 550-item true-false structured personality inventory, similar in format to the MMPI and was devised to measure subjective drug effects as well as psychopathology and personality characteristics. Haertzen (1965) developed a general drug control estimator scale (the General Drug Control- Estimation Scale [DE]) that can be used with empirical drug scales to show whether any particular subject is affected by or under the influence of a psychologically active drug. The DE scale can be considered effective for this purpose if scores on it are reliable, unaffected by drugs and correlated with all empirical drug effect scales. The DE scale meets all three criteria in an opiate addict population. DE is the most reliable scale on the ARCI using test-retest methods. It is as reliable or more reliable than scales in other standard personality inventories including the MMPI, Guilford-Zimmerman Temperament Survey, and the California Psychological Inventory, using the KR-20 internal consistency reliability statistic. The reliability of the scale was very high in several cross validation samples including nonaddict populations. In contrast to empirical drug scales, DE is highly resistant to drug effects. (PsycTESTS Database Record (c) 2016 APA, all rights reserved) KW - Addiction Research Center Inventory KW - Criterion Validity KW - General Drug Control Estimation Scale KW - Kuder-Richardson Reliability KW - Personality Measures KW - Psychopathology KW - Self Report KW - Test Development KW - Test Retest Reliability KW - True False U5 - Addiction Research Center Inventory: General Drug Control- Estimation Scale (ARCI-DE) [Test Development]Addiction Research Center Inventory (ARCI): Development of a general drug estimation scale. (AN: 1966-04754-001 from PsycINFO) Haertzen, Charles A.; 1965. Source: Journal of Nervous and Mental Disease. 141(3), Lippincott Williams & Wilkins, US; 1965; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Subjects with opiate addiction Keywords: Addiction Research Center Inventory; Criterion Validity; General Drug Control Estimation Scale; Kuder-Richardson Reliability; Personality Measures; Psychopathology; Self Report; Test Development; Test Retest Reliability; True False; Subjects: Drug Addiction; Drug Usage; Drug Usage Screening; Nonprojective Personality Measures; Psychopathology; Self-Report; Test Construction; Test Reliability; Test Validity; DO - 10.1037/t07373-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07373-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - Gen ID - 9999-06333-000 AN - 9999-06333-000 AU - Schaefer, Earl S. T1 - Child's Report of Parent Behavior Inventory JF - PsycTESTS JO - PsycTESTS Y1 - 1965/// AD - Schaefer, Earl S., National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland, United States, 20014 AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No N1 - Accession Number: 9999-06333-000. Acronyms: CRPBI. Partial author list: First Author & Affiliation: Schaefer, Earl S.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20130408. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: Participants are asked to indicate whether each item is like or not like their parent.. Language: English. Constructs: Parental Behavior; Perceived Parenting Behaviors; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). N2 - Administration Method: Paper AB - Purpose: The purpose of this inventory is to measure children's perceptions of their parents' behavior. AB - Description: Because a child's perception of his parents' behavior may be more related to his adjustment than is the actual behavior of his parents, the Child's Report of Parent Behavior Inventory (CRPBI; E. S. Schaefer, 1965) was developed. The selection of parental-behavior concepts was guided by a conceptual model that had been developed from factor analyses of psychologists' ratings of parental behavior. A scale for a concept was to consist of 10 homogeneous items that described relevant, specific, observable parental behaviors. Approximately 20 items were written for each concept. Each of three psychologists made a global evaluation of the 20 items for each concept on a three-point scale. The criteria for evaluation were clarity of the behavioral description, relevance of the item to the concept, applicability of the item to both father and mother, and high predicted item variance. A 10-item scale was then developed for each of the 26 concepts from those items which received the highest ratings. The inventory was administered to normal boys and girls aged 12-14 years and institutionalized delinquent boys aged 12-18 years. Both reliability data and analyses of group differences suggest that this inventory provides a sensitive method for investigating children's perceptions of parental behavior. (PsycTESTS Database Record (c) 2015 APA, all rights reserved) KW - Discriminant Validity KW - Test Development KW - Child's Report of Parent Behavior Inventory KW - Internal Consistency U5 - Child's Report of Parent Behavior Inventory (CRPBI) [Test Development]Children's reports of parental behavior: An inventory. (AN: 1965-12269-001 from PsycINFO) Schaefer, Earl S.; 1965. Source: Child Development. 36(2), Blackwell Publishing, United Kingdom; 1965; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Seventh-Grade Children and Institutionalized Delinquent Boys (Ages 12-18); Location: United States Keywords: Discriminant Validity; Test Development; Child's Report of Parent Behavior Inventory; Internal Consistency; Subjects: Child Attitudes; Inventories; Parental Characteristics; Test Construction; Test Reliability; Test Validity; DO - 10.1037/t06333-000 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-06333-000&site=ehost-live&scope=site DP - EBSCOhost DB - pst ER - TY - JOUR T1 - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE. AU - Surwillo, Walter W. AU - Quilter, Reginald E. JO - Psychophysiology JF - Psychophysiology Y1 - 1965/01// VL - 1 IS - 3 SP - 272 EP - 276 SN - 00485772 N1 - Accession Number: 11044659; Author: Surwillo, Walter W.: 1 Author: Quilter, Reginald E.: 1 ; Author Affiliation: 1 National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040119 N2 - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. ABSTRACT FROM AUTHOR KW - *GALVANIC skin response KW - VIGILANCE (Psychology) KW - SIGNAL detection (Psychology) KW - CONDITIONED response KW - MALES KW - BEHAVIORISM (Psychology) KW - AGE KW - Aging. KW - Autonomic KW - Skin Potential KW - Spontaneous SPR KW - Tarchanoff effect KW - Vigilance KW - Watchkeeping UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11044659&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR ID - 2013-39668-002 AN - 2013-39668-002 AU - Ozarin, Lucy D. AU - Brown, Bertram S. T1 - New directions in community mental health programs. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1965/01// VL - 35 IS - 1 SP - 10 EP - 17 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39668-002. Partial author list: First Author & Affiliation: Ozarin, Lucy D.; Community Mental Health Facilities Branch, National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Continuum of Care; Mental Health Programs. Minor Descriptor: Professional Consultation. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 1965. AB - New patterns of providing mental health services are emerging. A comprehensive range of readily available services close to where patients live and with continuity of care is the basis of the community mental health center concept. Implementation of the concept has shown that it results in changes in patient care and in professional practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - community mental health programs KW - mental health services KW - continuity of care KW - professional practices KW - 1965 KW - Community Mental Health Services KW - Continuum of Care KW - Mental Health Programs KW - Professional Consultation KW - 1965 DO - 10.1111/j.1939-0025.1965.tb02262.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39668-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Kohn, Melvin L. T1 - Social Class and Family Life (Book). JO - American Sociological Review JF - American Sociological Review Y1 - 1965/02// VL - 30 IS - 1 M3 - Book Review SP - 149 EP - 150 SN - 00031224 AB - Reviews the book "Social Class and Family Life," by Donald Gilbert McKinley. KW - SOCIAL classes KW - NONFICTION KW - MCKINLEY, Donald Gilbert KW - SOCIAL Class & Family Life (Book) N1 - Accession Number: 12766874; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Feb65, Vol. 30 Issue 1, p149; Subject Term: SOCIAL classes; Subject Term: NONFICTION; Reviews & Products: SOCIAL Class & Family Life (Book); People: MCKINLEY, Donald Gilbert; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12766874&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Bell, Richard Q. T1 - DEVELOPMENTAL PSYCHOLOGY. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1965/02// VL - 16 IS - 1 M3 - Article SP - 1 EP - 38 PB - Annual Reviews Inc. SN - 00664308 AB - Presents a review of literature in developmental psychology. Physical growth; Pregnancy and delivery; Early characteristics; Early stimulation; Learning in young organisms; perceptual and motor development; Cognition and language; Mental abilities; Social effects. KW - DEVELOPMENTAL psychology KW - CHILD development KW - CHILDREN KW - CHILD psychology KW - PSYCHOLOGY KW - PERIODICALS N1 - Accession Number: 11301340; Bell, Richard Q. 1; Affiliations: 1: Child Research Branch, National Institute of Mental Health; Issue Info: 1965, Vol. 16 Issue 1, p1; Subject Term: DEVELOPMENTAL psychology; Subject Term: CHILD development; Subject Term: CHILDREN; Subject Term: CHILD psychology; Subject Term: PSYCHOLOGY; Subject Term: PERIODICALS; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 38p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11301340&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - GEN AU - Mccutchen, C W T1 - Random code numbers for universal identification of documents JO - American Documentation JF - American Documentation Y1 - 1965/04// VL - 16 IS - 2 M3 - Article SP - 91 EP - 96 SN - 0096946X AB - Documents may be difficult to trace through (i) the absence of any visible authors, (ii) long titles laden with information, (iii) remoteness from the library's field of specialization. If every document was given, by the publisher, a random code number of 15 digits split into groups of 3, this could be used as its means of identification. Appendices discuss (i) the generation of random characters using a die and a latin square, (ii) the relative advantages of digits and letters, (iii) multiple assignment of numbers, (iv) cataloguing efficiency of random code numbers. N1 - Accession Number: ISTA0200201; Mccutchen, C W 1; Affiliations: 1 : Section On Rheumatic Diseases, Laboratory Of Experimental Pathology, National Institutes Of Health, Bethesda, Maryland; Source Info: April 1965, Vol. 16 Issue 2, p91; Note: Update Code: 0200; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0200201&site=ehost-live&scope=site DP - EBSCOhost DB - lih ER - TY - JOUR T1 - ON THE LAW OF INITIAL VALUE AND THE MEASUREMENT OF CHANGE. AU - Surwillo, Walter W. AU - Arenberg, David L. JO - Psychophysiology JF - Psychophysiology Y1 - 1965/04// VL - 1 IS - 4 SP - 368 EP - 370 SN - 00485772 N1 - Accession Number: 19001963; Author: Surwillo, Walter W.: 1 Author: Arenberg, David L.: 1 ; Author Affiliation: 1 National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; No. of Pages: 3; Language: English; Publication Type: Article; Update Code: 20051205 N2 - The article demonstrates the variable change measurements and the application of law of initial value (LIV) test in the study of autonomic variables in every individual within the experimental groups. The measurements on the changes without an intervening stimulus was presented using the criterion on pre-stimulus and post-stimulus values of variables by D. J. Hord, L. C. Johnson and A. Lubin. The LIV was demonstrated by using the heart rate data collected from the group when doing a simple reaction task. KW - *HEART beat KW - *CARDIAC contraction KW - INITIAL value problems KW - NUMERICAL analysis KW - CRITERION referenced tests UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=19001963&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR ID - 2013-39904-005 AN - 2013-39904-005 AU - Moss, Howard A. T1 - Methodological issues in studying mother-infant interaction. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1965/04// VL - 35 IS - 3 SP - 482 EP - 486 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39904-005. Partial author list: First Author & Affiliation: Moss, Howard A.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1964, Chicago, IL, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Interviews; Methodology; Mother Child Relations. Minor Descriptor: Infant Development. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 5. Issue Publication Date: Apr, 1965. AB - Direct observation is a highly suitable method for studying mother-infant relations. Although there are problems associated with this method they can be allayed through the use of certain tactics. On the other hand, indirect procedures (questionnaires, interviews) have serious limitations that are not easily overcome. The design and methodology of an observational study on mother-infant pairs are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - methodological issues KW - mother-infant interaction KW - mother-infant relations KW - interviews KW - 1965 KW - Interviews KW - Methodology KW - Mother Child Relations KW - Infant Development KW - 1965 DO - 10.1111/j.1939-0025.1965.tb00408.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39904-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - GEN AU - Brewer, Donna AU - Bunting, Sylvia L T1 - Data processing in clinical chemistry JO - Clinical Chemistry JF - Clinical Chemistry Y1 - 1965/05// VL - 11 IS - 5 M3 - Article SP - 595 EP - 611 SN - 00099147 AB - The flow of data in the clinical laboratory has been studied with respect to the types of personnel handling it and the ultimate use of the data. In order to promote higher efficiency, a data-processing system using punched cards has been devised and operated for a period of approximately 24 months. Forms, cards, and general considerations useful in such a system are described in detail. Some of the problems associated with this type of operation are discussed, as are the economics of this system and its general applicability. N1 - Accession Number: ISTA0100303; Brewer, Donna 1; Bunting, Sylvia L; Affiliations: 1 : National Institutes Of Health; Source Info: May 1965, Vol. 11 Issue 5, p595; Note: Update Code: 0100; Number of Pages: 17p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0100303&site=ehost-live&scope=site DP - EBSCOhost DB - lih ER - TY - JOUR AU - Kohn, Melvin L. T1 - Human Behavior: An Inventory of Scientific Findings. JO - American Sociological Review JF - American Sociological Review Y1 - 1965/06// VL - 30 IS - 3 M3 - Book Review SP - 433 EP - 433 SN - 00031224 AB - Reviews the book "Human Behavior: An Inventory of Scientific Findings," by Bernard Berelson and Gary A. Steiner. KW - HUMAN behavior KW - NONFICTION KW - BERELSON, Bernard KW - STEINER, Gary A. KW - HUMAN Behavior (Book) N1 - Accession Number: 12768446; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health, Bethesda and Institute for Social Research, Oslo; Issue Info: Jun65, Vol. 30 Issue 3, p433; Subject Term: HUMAN behavior; Subject Term: NONFICTION; Reviews & Products: HUMAN Behavior (Book); People: BERELSON, Bernard; People: STEINER, Gary A.; Number of Pages: 1p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12768446&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Raskin, Allen T1 - THE CONCEPT OF TASK VERSUS PERSON ORIENTATION IN NURSING. JO - Journal of Applied Psychology JF - Journal of Applied Psychology Y1 - 1965/06// VL - 49 IS - 3 M3 - Article SP - 182 EP - 187 SN - 00219010 AB - To clarify the concept of task versus person orientation in nursing, a factor analysis of 24 personality- and nursing-attitude variables was performed on 160 nurses from long- and short-term treatment settings in psychiatry and general medicine. 3 factors, Leadership Skills, Hostile-Self-Seeking, and Dependent-Exploited sampled behaviors in the interpersonal sphere and particularly traits related to leadership capability. The 4th factor, Impersonal- Orderly, contained many characteristics of the "Authoritarian Personality." An emphasis on the skilled technical aspects of nursing was one of the elements in this factor. In general, the derived factor scores effectively differentiated nurses from the treatment settings in this study. [ABSTRACT FROM AUTHOR] AB - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - LEADERSHIP KW - NURSING KW - MEDICINE KW - PERSONALITY KW - ABILITY testing KW - APPLIED psychology N1 - Accession Number: 12428797; Raskin, Allen 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland.; Issue Info: Jun65, Vol. 49 Issue 3, p182; Thesaurus Term: LEADERSHIP; Subject Term: NURSING; Subject Term: MEDICINE; Subject Term: PERSONALITY; Subject Term: ABILITY testing; Subject Term: APPLIED psychology; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12428797&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Zelen, Marvin T1 - Statistical Assessment of the Life Characteristic (Book). JO - Journal of the American Statistical Association JF - Journal of the American Statistical Association Y1 - 1965/06// VL - 60 IS - 310 M3 - Book Review SP - 681 SN - 01621459 AB - Reviews the book "Statistical Assessment of the Life Characteristic: A Bibliographic Guide," by W.R. Buckland. KW - STATISTICS KW - NONFICTION KW - BUCKLAND, William R. KW - STATISTICAL Assessment of the Life Characteristic: A Bibliographic Guide (Book) N1 - Accession Number: 4605679; Zelen, Marvin 1; Affiliations: 1: National Cancer Institute.; Issue Info: Jun65, Vol. 60 Issue 310, p681; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: STATISTICAL Assessment of the Life Characteristic: A Bibliographic Guide (Book); People: BUCKLAND, William R.; Number of Pages: 2p; Document Type: Book Review UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4605679&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2006-06071-002 AN - 2006-06071-002 AU - Bobbitt, Joseph M. T1 - Old Folks Not at Home. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1965/06// VL - 10 IS - 6 SP - 243 EP - 243 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06071-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Bobbitt, Joseph M.; National Institute of Child Health and Human Development, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Distress; Elder Care; Hospitalization; Psychiatric Units; Psychodiagnosis. Minor Descriptor: Hospitals; Schema; Urban Environments. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Lowenthal, Marjorie Fiske. Lives in Distress: The Paths of the Elderly to the Psychiatric Ward=New York: Basic Books, 1964. Pp. xx + 266. $5.95; 1964. Page Count: 1. Issue Publication Date: Jun, 1965. AB - Reviews the book, Lives in Distress: The Paths of the Elderly to the Psychiatric Ward by Marjorie Fiske Lowenthal (see record [rid]1965-02262-000[/rid]). The book tells the story of how elderly people reach the psychiatric screening wards of a large city general hospital--in this case, San Francisco. California. It is a report on how these elderly persons, defined as those sixty years of age or oær, are hospitalized for the first time for psychiatric reasons. It attempts to report and analyze the proximate series of events leading to these hospitalizations. What has been said should indicate that Friske's book is a real contribution to the literature and one that will serve a real purpose. It is necessary, however, to tarnish just a little this highly favorable response by indicating that the book is not highly readable. It tends to present factual statements that fail to achieve great significance or impressivencss because they are not related to conceptual positions or comprehensive schema that give them additional meaning or that make them easy to remember. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychiatric screening wards KW - elder care KW - distress KW - hospitalization KW - aged KW - gerontology KW - 1965 KW - Distress KW - Elder Care KW - Hospitalization KW - Psychiatric Units KW - Psychodiagnosis KW - Hospitals KW - Schema KW - Urban Environments KW - 1965 U2 - Lowenthal, Marjorie Fiske. (1964); Lives in Distress: The Paths of the Elderly to the Psychiatric Ward; New York: Basic Books, 1964. Pp. xx + 266. $5.95 DO - 10.1037/007968 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06071-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2006-06071-009 AN - 2006-06071-009 AU - Arnhoff, Franklyn T1 - Distaff Psychopathology. JF - Contemporary Psychology JO - Contemporary Psychology Y1 - 1965/06// VL - 10 IS - 6 SP - 254 EP - 255 CY - US PB - American Psychological Association SN - 0010-7549 N1 - Accession Number: 2006-06071-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Arnhoff, Franklyn; Program Analysis Section, Training and Manpower Resources Branch, National Institute of Mental Health, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Females; Mental Health; Psychopathology; Psychosocial Factors; Schizophrenia. Minor Descriptor: Family Members. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Reviewed Item: Sampson, Harold; Messinger, Sheldon L.; Towne, Robert D. Schizophrenic Women: Studies in Marital Crisis=New York: Atherton Press, 1964. Pp. xiv + 111. $4 95; 1964. Page Count: 2. Issue Publication Date: Jun, 1965. AB - Reviews the book, Schizophrenic Women: Studies in Marital Crisis by Harold Sampson, Sheldon L. Messinger, and Robert D. Towne (see record [rid]1965-08511-000[/rid]). This is the modern Zeitgeist which provides the orientation for the present study: an attempt to provide understanding of the disruption in family living caused by psychiatric crisis and ensuing hospitahzation-a critical period in the lives of all members of the families involved. The study deals with the patterns of life prior to hospitalization, hospitalization itself, and a period following release; what the authors characterize as a sequence of 'organization- disorganization-reorganization. The summary and conclusions of the book provide a good discussion of the social psychological factors and forces impinging upon the mentally disturbed individual as they relate to various tieatment facilities While not new information, it is thoughtful and well presented, providing a short overview for anyone interested in these major, current, social psychological mental health problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health problems KW - schizophrenic women KW - marital crisis KW - social psychological factors KW - 1965 KW - Human Females KW - Mental Health KW - Psychopathology KW - Psychosocial Factors KW - Schizophrenia KW - Family Members KW - 1965 U2 - Sampson, Harold; Messinger, Sheldon L.; Towne, Robert D. (1964); Schizophrenic Women: Studies in Marital Crisis; New York: Atherton Press, 1964. Pp. xiv + 111. $4 95 DO - 10.1037/007975 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06071-009&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Stachowiak, James G. AU - Moss, C. Scott T1 - HYPNOTIC ALTERATION OF SOCIAL ATTITUDES. JO - Journal of Personality & Social Psychology JF - Journal of Personality & Social Psychology Y1 - 1965/07// VL - 2 IS - 1 M3 - Article SP - 77 EP - 83 SN - 00223514 AB - This study measures the effectiveness of influencing S attitudes toward Negroes through the medium of a hypnotically administered communication. Precision was added by conceptualizing the interaction between 2 variables, the concept to be influenced (Negro) and the source of the influence (hypnotist), within the theoretical model provided by Osgood's principle of congruity. Ss who were exposed to a positive communication about Negroes while they were hypnotized showed significantly greater attitude change than did Ss who were exposed to the same communication in the "waking state." Predictions generated by the congruity principle held up well with respect to direction of attitude change, but insufficiencies were evident with regard to predictions of the magnitude of the changes. [ABSTRACT FROM AUTHOR] AB - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - SOCIAL influence KW - INFLUENCE (Psychology) KW - SOCIAL psychology KW - ATTITUDE (Psychology) KW - FORECASTING KW - CHANGE (Psychology) KW - DECISION MAKING AND COMMUNICATIONS KW - Patterns of opinion spread and opinion change KW - Psychological factors affecting tension N1 - Accession Number: 16643947; Stachowiak, James G. 1; Moss, C. Scott 2; Affiliations: 1 : University of Kansas.; 2 : National Institute of Mental Health, San Francisco, California.; Source Info: Jul65, Vol. 2 Issue 1, p77; Subject Term: SOCIAL influence; Subject Term: INFLUENCE (Psychology); Subject Term: SOCIAL psychology; Subject Term: ATTITUDE (Psychology); Subject Term: FORECASTING; Subject Term: CHANGE (Psychology); Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Author-Supplied Keyword: Psychological factors affecting tension; Number of Pages: 7p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=16643947&site=ehost-live&scope=site DP - EBSCOhost DB - 24h ER - TY - JOUR AU - Boomer, Donald S. T1 - HESITATION AND GRAMMATICAL ENCODING. JO - Language & Speech JF - Language & Speech Y1 - 1965/07//Jul-Sep65 VL - 8 IS - 3 M3 - Article SP - 148 EP - 158 PB - Sage Publications, Ltd. SN - 00238309 AB - The article focuses on a study that concerns in the occurrence of filled and unfilled pauses of hesitations with respect to their location in phonemic clauses in spontaneous English speech. Both types of hesitation were most frequent after the first word in the clause, regardless of length. In this study, the data to be presented concern the location of these hesitations in extended utterances, but the basic theoretical issue involved is the nature of the grammatical encoding process in speech. These data are regarded as directly challenging the transitional probability theory of hesitations. In addition, the phonemic clause is proposed as the encoding unit of speech at the grammatical level. KW - Speech -- Study & teaching KW - Language & languages -- Study & teaching KW - Hesitation form (Linguistics) KW - Clauses (Grammar) KW - Juncture (Linguistics) KW - Linguistics KW - Phonetics KW - English language -- Study & teaching KW - Phonological encoding N1 - Accession Number: 21832518; Boomer, Donald S. 1,2; Affiliations: 1: National Institute of Mental Health, Bethesda; 2: Laboratory of Psychology, National Institute of Mental Health, National Institutes of Health, Department of Health, Education and Welfare; Issue Info: Jul-Sep65, Vol. 8 Issue 3, p148; Thesaurus Term: Speech -- Study & teaching; Thesaurus Term: Language & languages -- Study & teaching; Thesaurus Term: Hesitation form (Linguistics); Thesaurus Term: Clauses (Grammar); Thesaurus Term: Juncture (Linguistics); Thesaurus Term: Linguistics; Thesaurus Term: Phonetics; Subject Term: English language -- Study & teaching; Subject Term: Phonological encoding; NAICS/Industry Codes: 611630 Language Schools; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=21832518&site=ehost-live&scope=site DP - EBSCOhost DB - ufh ER - TY - JOUR ID - 2013-39739-026 AN - 2013-39739-026 AU - Bower, Eli M. T1 - Review of The tyranny of schooling: An inquiry into the problem of 'stupidity'. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1965/07// VL - 35 IS - 4 SP - 802 EP - 804 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39739-026. Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Academic Achievement; Academic Aptitude; Educational Standards. Minor Descriptor: Goals; Mind; Shame. Classification: Academic Learning & Achievement (3550). Population: Human (10). Reviewed Item: Dexter, Lewis Anthony. The tyranny of schooling: An inquiry into the problem of stupidity=New York: Basic Books, 182 pp. $4.50; 1964. Page Count: 3. Issue Publication Date: Jul, 1965. AB - Reviews the book, The Tyranny of Schooling: An Inquiry into the Problem of 'Stupidity' by Lewis Anthony Dexter (see record [rid]1965-02789-000[/rid]). Among the many significant properties of bath water two are to provide a place to sing operatic arias in relative safety and to provide an aqueous propellant to accompany mythical babies being tossed out illusory windows. The book illustrates this second function with full fruition. The author argues that the major goal of the educational institutions is intellectual achievement and that most if not all students do substandard work at one time or another in one subject or another. As a result of this built-in failure, feelings of stupidity or incompetence are developed to less or greater degrees. This, the author believes, is especially applicable to the dull, retarded, or other non-academically minded children. The author feels that schools operate to teach many of the children with superior or normal ability the humiliation and shame of being branded stupid and inadequate. The book considers the problem and several alternatives in a 'variations on a theme' context. This is a kind of desk-pounding, college debating book which tries not to complicate the issues by attempting to understand them. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - educational institutions KW - intellectual achievement KW - goals KW - shame KW - stupidity KW - academic mind KW - 1965 KW - Academic Achievement KW - Academic Aptitude KW - Educational Standards KW - Goals KW - Mind KW - Shame KW - 1965 U2 - Dexter, Lewis Anthony. (1964); The tyranny of schooling: An inquiry into the problem of stupidity; New York: Basic Books, 182 pp. $4.50 DO - 10.1111/j.1939-0025.1965.tb00456.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39739-026&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39739-032 AN - 2013-39739-032 AU - Wiener, Jack T1 - Mental health highlights. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1965/07// VL - 35 IS - 4 SP - 813 EP - 816 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39739-032. Partial author list: First Author & Affiliation: Wiener, Jack; Program Analysis Section, Community Research and Services Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Mental Health Programs; Orthopsychiatry; Scientific Communication. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jul, 1965. AB - This editorial discusses the present issue of American Journal of Orthopsychiatry which briefly reports the recent legislation, program innovations and program research of national significance to the field of mental health. Mental health history is being made on the Potomac. The year 1965 may prove to be a landmark in the development of the nation's mental health services. Broad social measures, such as the new federal education aid law, presumably will have a general mental health impact. The Appalachia Regional Development Act of 1965 which was approved, has important provisions concerning mental health facilities. The act makes it possible to set up demonstrations of multi-county health centers in several of the isolated and impoverished areas of the region. The Medicare Bill was approved by the House of Representatives on April 8, 1965 and this complex, omnibus bill has important provisions which go beyond services for the aged and directly concern mental health and mental retardation programs. The Child Mental Health Bill is designed to provide federal funds for projects to identify and treat emotionally disturbed children. In 1965, state legislatures in Idaho, North Dakota and Tennessee passed laws authorizing state grants in- id to locally administered community mental health programs. A total of 24 states now have these community mental health acts. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - orthopsychiatry KW - community mental health services KW - scientific communication KW - mental health programs KW - 1965 KW - Community Mental Health Services KW - Mental Health Programs KW - Orthopsychiatry KW - Scientific Communication KW - 1965 DO - 10.1111/j.1939-0025.1965.tb00458.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39739-032&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2005-16485-008 AN - 2005-16485-008 AU - Kallen, David J. T1 - Behavioral Science Research in Growth and Development. JF - American Psychologist JO - American Psychologist JA - Am Psychol Y1 - 1965/08// VL - 20 IS - 8 SP - 689 EP - 691 CY - US PB - American Psychological Association SN - 0003-066X SN - 1935-990X N1 - Accession Number: 2005-16485-008. Partial author list: First Author & Affiliation: Kallen, David J.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavioral Sciences; Experimentation; Human Development. Minor Descriptor: Biology; Cognitive Development; Personality Development; Psychosocial Development. Classification: General Psychology (2100). Population: Human (10). Page Count: 3. Issue Publication Date: Aug, 1965. Copyright Statement: American Psychological Association. 1965. AB - This paper represents an initial attempt to spell out some of the areas which will be given major emphasis by the Behavioral Science Program of the Growth and Development Program, National Institute of Child Health and Human Development (NICHD). Although the Institute feels that these areas are among the most important ones relating to its current program interests, these suggestions are to be regarded as permissive and not controlling. The Institute will be constantly alert to, and willing to support a number of, high-risk projects in which the probabilities of payoff are not great, but in which payoff, if it does occur, would make an exciting, important, and meaningful contribution to the understanding of human growth and development. The paper highlights the areas that will be of primary interest to the program which include: 1)the biological bases and mechanisms of behavior; 2) cognition, learning, perception and environmental mastery; 3) social growth and cultural contexts and; 4) personality development. The author also discusses the importance of linkages. It is important to remain alert to innovations in concept, in method, and in areas of investigation, which will lead to fruitful new approaches to the understanding of human growth and development. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - human growth KW - behavioral science research KW - personality development KW - social growth KW - cognitive style KW - behavior KW - linkages KW - biology KW - 1965 KW - Behavioral Sciences KW - Experimentation KW - Human Development KW - Biology KW - Cognitive Development KW - Personality Development KW - Psychosocial Development KW - 1965 DO - 10.1037/h0021460 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16485-008&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Asheron, G. L. AU - Stone, S. H. T1 - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig I. IMMUNE DEVIATION: DESCRIPTION OF THE PHENOMENON AND THE EFFECT OF SPENECTOMY. JO - Immunology JF - Immunology Y1 - 1965/09// VL - 9 IS - 3 M3 - Article SP - 205 EP - 217 SN - 00192805 AB - Strong 24 hour skin reactions occur in guinea-pigs immunized with antigen in Freund's complete adjuvant. These reactions were reduced by the injection of 1 mg of the same antigen, in either the soluble or alum precipitated form, 14 days before immunization with antigen in Freund's complete adjuvant. There was also a reduction in the corneal reaction, which has been regarded as an index of delayed hypersensitivity. This phenomenon was called immune deviation. The phenomenon was demonstrated for bovine γ-globulin, human serum albumin, bovine serum albumin, egg albumin, diptheria toxoid, hacmocyanin, purified protein derivative (PPD) and dinitrophenylated proteins. Ten mg of soluble bovine γ-globulin caused considerable reduction of the circulating antibody level and of the 24 hour skin reaction. Alum precipitated bovine γ-globulin and smaller doses of soluble antigen reduced the skin reaction but had less effect on the antibody level. Similar results were obtained with human serum albumin. This suggested that the conditions for eliciting immune paralysis and immune deviation were different. Immune deviation was obtained with either footpad or intravenous injections and with as little as 100 µg of antigen. Alum precipitated bovine γ-globulin caused immune deviation when given 14, 7 or 1 day before or 1 day after immunization with antigen in Freund's complete adjuvant. It was inactive when given 6 days after immunization. Splenectomy had no effect on the production or deviation of 24 hour skin reactions. Alum precipitated antigen had a variable and usually slight effect on the level of antibody following immunization with the same antigen in Freund's complete adjuvant. There was, however, a qualitative alteration in the antibody. The sera of guinea-pigs, which had been deviated by a prior injection of bovine serum albumin or bovine γ-globulin, showed only a gamma;1 line of antibody on immunoelectrophoresis, while the sera of control guinea-pigs also showed the γ2 line characteristically seen in guinea-pigs immunized with antigen in Freund's complete adjuvant. It was concluded that immune deviation was distinct from classical immune paralysis and that the immunologically specific reduction of the 24 hour skin reactions might be due, at least in part, to a selective loss of delayed hypersensitivity. [ABSTRACT FROM AUTHOR] AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - IMMUNIZATION KW - ANTIGENS KW - DELAYED hypersensitivity KW - GLOBULINS KW - ALBUMINS KW - PROTEINS KW - IMMUNOGLOBULINS KW - ALUM KW - SPLENECTOMY KW - ANIMAL models in research N1 - Accession Number: 13279305; Asheron, G. L. 1; Stone, S. H. 2; Source Information: Sep65, Vol. 9 Issue 3, p205; Subject: IMMUNIZATION; Subject: ANTIGENS; Subject: DELAYED hypersensitivity; Subject: GLOBULINS; Subject: ALBUMINS; Subject: PROTEINS; Subject: IMMUNOGLOBULINS; Subject: ALUM; Subject: SPLENECTOMY; Subject: ANIMAL models in research; Number of Pages: 13p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=13279305&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR T1 - AN AUTOMATIC ANALYZER OF STATES OF VIGILANCE. AU - Berger, Ralph J. AU - Meier, Gilbert W. JO - Psychophysiology JF - Psychophysiology Y1 - 1965/10// VL - 2 IS - 2 SP - 141 EP - 145 SN - 00485772 N1 - Accession Number: 11046049; Author: Berger, Ralph J.: 1 Author: Meier, Gilbert W.: 1 ; Author Affiliation: 1 Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040119 N2 - An assemblage of relay-operated, commercially available programming modules is described. It is capable of discriminating among the states of vigilance - wakefulness (W); high-voltage, slow-wave sleep (HVS); and low-voltage, fast-wave sleep (LVF) - and it requires information from only the nuchal electromyogram (EMG) and the electrooculogram (EOG). ABSTRACT FROM AUTHOR KW - *NEURAL analyzers KW - *SLEEP KW - *CENTRAL nervous system KW - VIGILANCE (Psychology) KW - SLEEP-wake cycle KW - DREAMS KW - Analyzer KW - Dreaming. KW - Sleep KW - Vigilance UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11046049&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR AU - Stone, Frederick L. AU - Brown, J. H. U. T1 - TECHNOLOGY IN MEDICINE. JO - BioScience JF - BioScience Y1 - 1965/11// VL - 15 IS - 11 M3 - Article SP - 716 EP - 719 SN - 00063568 AB - The National Institutes of Health are giving widespread support to biomédical engineering research projects and training in a great variety of institutions and settings. Multidisciplinary projects are being conducted in research institutes, general clinical centers, regional primate research centers, hospitals, and medical centers. [ABSTRACT FROM AUTHOR] AB - Copyright of BioScience is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - Biomedical engineering -- Research KW - Interdisciplinary approach in education KW - Medical technology KW - Research institutes KW - Medical centers KW - Hospitals KW - Medical research KW - United States KW - National Institutes of Health (U.S.) N1 - Accession Number: 31932241; Stone, Frederick L. 1; Brown, J. H. U.; Affiliations: 1 : Director, National Institute of General Medical Sciences, National Institutes of Health.; Source Info: Nov1965, Vol. 15 Issue 11, p716; Subject Term: Biomedical engineering -- Research; Subject Term: Interdisciplinary approach in education; Subject Term: Medical technology; Subject Term: Research institutes; Subject Term: Medical centers; Subject Term: Hospitals; Subject Term: Medical research; Subject: United States; Number of Pages: 4p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=8gh&AN=31932241&site=ehost-live&scope=site DP - EBSCOhost DB - 8gh ER - TY - GEN AU - Epstein, Martin N AU - Maloney, Clifford J. T1 - Progress in internal indexing JO - In American Documentation Institute. Proceedings Of The Annual Meeting, October 3-7, 1966, Santa Monica, Calif. V. 3. (1966). P. 57-62. See 66-957 JF - In American Documentation Institute. Proceedings Of The Annual Meeting, October 3-7, 1966, Santa Monica, Calif. V. 3. (1966). P. 57-62. See 66-957 Y1 - 1966/// M3 - Book Chapter AB - A method of computer assisted prepartion of internal indexes has been perfected and (hopefully) tested in an operating environment. Index preparation involves both much intellectual discrimination and much clericaldrudgery. The computer is well adapted to performing the latter while actually facilitating performance of the former by a human post editor. As a result, the quality of the output is that of manual indexing, indeed, the computer capabilities encourage and permit the editor to polish his output free of cost and time restraints. The widespread appearance of books, symposia proceedings, and research reports devoid of indexes emphasizes the need. The machine capabilities permit the provision of much fuller indexing than now attempted. The latter facilitates professional rather than author internal indexing. N1 - Accession Number: ISTA0100747; Epstein, Martin N 1; Maloney, Clifford J. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, M; Source Info: 1966; Note: Update Code: 0100; Document Type: Book Chapter UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0100747&site=ehost-live&scope=site DP - EBSCOhost DB - lih ER - TY - JOUR ID - 2013-39905-030 AN - 2013-39905-030 AU - Wiener, Jack T1 - Mental health highlights. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/01// VL - 36 IS - 1 SP - 172 EP - 175 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39905-030. Partial author list: First Author & Affiliation: Wiener, Jack; Program Analysis Section, Community Research and Services Branch, National Institute of Mental Health, MA, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Partial Hospitalization; Project Head Start. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1966. AB - This article presents mental health highlights, which focuses on Older Americans, Manpower in Corrections, Joint Commission on Mental Health of Children, Battered Child, Day Care for Special Children, Ahead of Head Start, and many other related topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health highlights KW - battered child KW - day care KW - special children KW - head start KW - 1966 KW - Mental Health KW - Partial Hospitalization KW - Project Head Start KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02305.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39905-030&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Dittmann, Allen T. T1 - PSYCHOTHERAPEUTIC PROCESSES. JO - Annual Review of Psychology JF - Annual Review of Psychology Y1 - 1966/02// VL - 17 IS - 1 M3 - Article SP - 51 PB - Annual Reviews Inc. SN - 00664308 AB - Examines various literature on psychotherapeutic process. Methodological discussions; Studies of outcome; Characteristics of patients and therapists; Research on the interview. KW - PSYCHOTHERAPY KW - PSYCHOLOGICAL literature N1 - Accession Number: 11298999; Dittmann, Allen T. 1; Affiliations: 1: National Institute of Mental Health in Bethesda, Maryland; Issue Info: 1966, Vol. 17 Issue 1, p51; Subject Term: PSYCHOTHERAPY; Subject Term: PSYCHOLOGICAL literature; Number of Pages: 28p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=11298999&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR AU - Burton, Roger V. AU - Allinsmith, Wesley AU - Maccoby, Eleanor E. T1 - RESISTANCE TO TEMPATION IN RELATION TO SEX OF CHILD, SEX OF EXPERIMENTER, AND WITHDRAWAL OF ATTENTION. JO - Journal of Personality & Social Psychology JF - Journal of Personality & Social Psychology Y1 - 1966/03// VL - 3 IS - 3 M3 - Article SP - 253 EP - 258 SN - 00223514 AB - Sex of E sex of child, withdrawal of attention, and their interactions were tested for their effects on resistance to temptation in 112 4-yr.-old children. The measure of resistance was obtained by testing whether or not a child, when left by himself and tempted to get a high score by cheating, would play a game according to rules established by an adult. Children conformed to the rules more with an adult of the opposite sex. Withdrawal of attention increased heating for boys but had no effect on girls. Several possible interpretations of these results are considered. The desire to please a cross-sex adult, the arousal of achievement motivation by a same-sex adult which may be increased in boys by withdrawal of attention, and resentment at withdrawn attention on the part of boys, could be involved either singly or in combination. [ABSTRACT FROM AUTHOR] AB - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - CHILDREN & sex KW - MOTIVATION (Psychology) KW - ACHIEVEMENT motivation KW - CHILDREN -- Sexual behavior KW - SEX education for children KW - GENDER role in children KW - DECISION MAKING AND COMMUNICATIONS KW - Effect of group pressure on individual opinion KW - Psychological factors affecting tension KW - Social and Cultural Factors Affection Tension N1 - Accession Number: 16644347; Burton, Roger V. 1; Allinsmith, Wesley 2; Maccoby, Eleanor E. 3; Affiliations: 1 : Laboratory of Socio-Environmental Studies, National Institute of Mental Health, Bethesda, Maryland; 2 : University of Cincinnati; 3 : Stanford University.; Source Info: Mar66, Vol. 3 Issue 3, p253; Subject Term: CHILDREN & sex; Subject Term: MOTIVATION (Psychology); Subject Term: ACHIEVEMENT motivation; Subject Term: CHILDREN -- Sexual behavior; Subject Term: SEX education for children; Subject Term: GENDER role in children; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Effect of group pressure on individual opinion; Author-Supplied Keyword: Psychological factors affecting tension; Author-Supplied Keyword: Social and Cultural Factors Affection Tension; Number of Pages: 4p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=16644347&site=ehost-live&scope=site DP - EBSCOhost DB - 24h ER - TY - GEN AU - Haenszel, W AU - Lourie, W I, Jr T1 - Quality control of data in a large-scale cancer register program JO - Methods of Information in Medicine JF - Methods of Information in Medicine Y1 - 1966/04// VL - 5 IS - 2 M3 - Article SP - 67 EP - 74 SN - 00261270 AB - Quality control of data collected in the united states by the cancer end results program utilizing punchcards prepared by the participating registries in accordance with a uniform punchcard code is dicussed. Existing arrangements decentralize responsibility for editing and related data processing to the local registries with centralization of tabulating and statistical services in the end results section, national cancer institute. The most recent deck of punchcards represented over 600,000 cancer patients; approximately 50,000 newly diagnosed cases are added annually. Mechanical editing and inspection of punchcards and field audits are the principal tools for quality control. Mechanical editing of the punchcards incoudes testing for blank entries and detection of inadmissible or inconsistent codes. Highly improbable codes are subjected to special scrutiny. Field audits include the drawing of 1 to 10 percent random sample of punchcards submitted by a registry; the charts are then reabstracted and recorded by a nci staff member and differences between the punchcards and the results of independent review are noted. N1 - Accession Number: ISTA0100324; Haenszel, W 1; Lourie, W I, Jr; Affiliations: 1 : National Cancer Institute; Source Info: April 1966, Vol. 5 Issue 2, p67; Note: Update Code: 0100; Number of Pages: 8p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0100324&site=ehost-live&scope=site DP - EBSCOhost DB - lih ER - TY - JOUR T1 - SIGNIFICANCE AND RELIABILITY OF SHOCK-IN-DUCED CHANGES IN BASAL SKIN CONDUCTANCE. AU - Jones, B. E. AU - Ayres, J. J. B. JO - Psychophysiology JF - Psychophysiology Y1 - 1966/04// VL - 2 IS - 4 SP - 322 EP - 326 SN - 00485772 N1 - Accession Number: 11047181; Author: Jones, B. E.: 1 Author: Ayres, J. J. B.: 1 ; Author Affiliation: 1 National Institute of Mental Health Addiction Research Center, Lexington, Kentucky.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20031229 N2 - Once weekly for 5 weeks, 15 adult male postaddicts were given 12 to 15 shocks of 5.0 to 8.0 ma. Basal skin conductance (BSC) was recorded during the 25-rain weekly sessions. Increases in BSC during each session and the week-to-week reliabilities of the increases were determined. After the first week, subsequent increases showed reliability coefficients which ranged from 0.69 to 0.95 (P < 0.01). The reliabilities of the increases in BSC produced by shock were considered favorable for the use of change in BSC as a dependent variable in designs requiring repeated measurements on the same Ss at weekly intervals. ABSTRACT FROM AUTHOR KW - *GALVANIC skin response KW - *REFLEXES KW - *SKIN KW - *PHYSIOLOGY KW - RELIABILITY (Personality trait) KW - Basal Skin Conductance. (B. E. Jones) KW - Methodology UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11047181&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR T1 - THE EFFECTS OF SELECTIVE DEPRIVATION OF STATES OF SLEEP IN THE DEVELOPING MONKEY. AU - Berger, Ralph J. AU - Meier, Gilbert W. JO - Psychophysiology JF - Psychophysiology Y1 - 1966/04// VL - 2 IS - 4 SP - 354 EP - 371 SN - 00485772 N1 - Accession Number: 11047250; Author: Berger, Ralph J.: 1 Author: Meier, Gilbert W.: 1 ; Author Affiliation: 1 Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20031229 N2 - Four groups, two comprising three neonatal rhesus monkeys and two comprising two juvenile rhesus monkeys, were selectively deprived of either low-voltage, fastwave sleep (LVF) or of high.voltage, slow-wave sleep (HVS), respectively. Both infant and juvenile Ss displayed an over-all increase in threshold to the tone-shock combination during the deprivation of either phase of sleep. However, the thresholds of the infant Ss were greater, throughout deprivation, than the thresholds of the juvenile Ss. The juvenile Ss exposed to LVF deprivation were unique in exhibiting a sharp increase in frequency of forced awakenings from LVF, to values significantly greater than for the other groups, and in displaying compensatory recovery effects, manifested by increases in proportion of total sleep time spent in LVF, following termination of deprivation. Behavioral disturbances accompanying deprivation were not evident in any of the experimental groups. The study revealed a number of methodological problems related to the definition and to the selective deprivation of a particular state of sleep. ABSTRACT FROM AUTHOR KW - *SLEEP deprivation KW - *AROUSAL (Physiology) KW - *PSYCHOPHYSIOLOGY KW - *ONTOGENY KW - Arousal KW - Dream deprivation KW - Ontogeny. (R. J. Berger) KW - Sleep deprivation UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11047250&site=ehost-live&scope=site DP - EBSCOhost DB - s3h ER - TY - JOUR ID - 2013-39906-001 AN - 2013-39906-001 AU - Shore, Milton F. T1 - Lip service to research and evaluation? JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/04// VL - 36 IS - 3 SP - 397 EP - 398 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39906-001. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Community Mental Health Services; Evaluation; Experimentation; Health Care Services. Minor Descriptor: Scientific Communication. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Apr, 1966. AB - This editorial, discusses, the community mental health center lists as the tenth and last service in a comprehensive community mental health center the area of research and evaluation. Although the order of services written into the Act was not intentional, there has been a tendency on the part of communities which are planning new mental health services to interpret this listing as a model of priorities of service. The development of new techniques does not mean compromising the basic elements of scientific inquiry. It means developing new ways of eliminating biases, testing reliability, selecting control groups, developing measures of subtle behavioral changes. They have an obligation to society and to ourselves as professionals and scientists not only to believe that the services we are giving are effective but to show it in an objective and sophisticated manner. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - community mental health center KW - health services KW - evaluation KW - research KW - scientific inquiry KW - 1966 KW - Community Mental Health Services KW - Evaluation KW - Experimentation KW - Health Care Services KW - Scientific Communication KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02381.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-001&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39906-002 AN - 2013-39906-002 AU - Duhul, Leonard J. T1 - The President's Crime Commission. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/04// VL - 36 IS - 3 SP - 398 EP - 399 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39906-002. Partial author list: First Author & Affiliation: Duhul, Leonard J.; Office of Planning, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Crime Prevention; Law Enforcement; Police Personnel; Public Health. Minor Descriptor: Justice; Laws; Rehabilitation; Safety. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 1966. AB - The President's Crime Commission has invited the American Orthopsychiatric Association to cooperate in the preparation of its report. The Commission invites us to participate in working sessions and in the provision of documents proposing innovations in a variety of areas: the assessment of the scope of the problem, the evaluation of causal factors, the problem of correction and rehabilitation, of law enforcement, public safety and the administration of justice. The Association welcomes the Commission heartily. Just as heartily, it hopes that the final report will reflect the broad viewpoints on crime and its prevention that come from fields other than police and the law alone. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - public safety KW - administration of justice KW - law enforcement KW - rehabilitation KW - crime prevention KW - police KW - laws KW - 1966 KW - Crime Prevention KW - Law Enforcement KW - Police Personnel KW - Public Health KW - Justice KW - Laws KW - Rehabilitation KW - Safety KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02382.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-002&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39906-013 AN - 2013-39906-013 AU - Pollin, William AU - Stabenau, James R. AU - Mosher, Loren AU - Tupin, Joe T1 - Life history differences in identical twins discordant for schizophrenia. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/04// VL - 36 IS - 3 SP - 492 EP - 509 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39906-013. PMID: 5910515 Partial author list: First Author & Affiliation: Pollin, William; Section on Twin and Sibling Studies, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1965, New York, NY, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Life Span; Life Sustaining Treatment; Monozygotic Twins; Schizophrenia. Minor Descriptor: Parents. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Followup Study; Interview; Quantitative Study; Twin Study. References Available: Y. Page Count: 18. Issue Publication Date: Apr, 1966. AB - Eleven pairs of identical twins, in which one had been previously hospitalized for schizophrenia or borderline schizophrenia, have been intensively studied, along with their parents, at the National Institutes of Health. A number of interacting features tend to consistently differentiate the life course of the index from the control twins. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - life history differences KW - borderline schizophrenia KW - control twins KW - identical twins KW - life course KW - 1966 KW - Life Span KW - Life Sustaining Treatment KW - Monozygotic Twins KW - Schizophrenia KW - Parents KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02393.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-013&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-39906-017 AN - 2013-39906-017 AU - Waldrop, Mary F. AU - Bell, Richard Q. T1 - Effects of family size and density on newborn characteristics. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/04// VL - 36 IS - 3 SP - 544 EP - 550 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-39906-017. PMID: 5910519 Partial author list: First Author & Affiliation: Waldrop, Mary F.; Child Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, New York, NY, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Family Size; Infant Development; Pregnancy. Minor Descriptor: Behavior. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1966. AB - Infants born to mothers who had experienced a large number of closely spaced pregnancies were found to be more lethargic than infants born to mothers who had experienced fewer pregnancies more widely spaced. Highly lethargic infants on follow-up at age two-and-a-half exhibited greater dependency behavior than children who as infants were low in lethargy. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - family size KW - density KW - newborn characteristics KW - infant development KW - pregnancy KW - dependency behavior KW - 1966 KW - Family Size KW - Infant Development KW - Pregnancy KW - Behavior KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02397.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39906-017&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 84005096 T1 - Doctor Thornton and his Capitol. AU - Lindgren, Keith M. AU - Lindgren, K M Y1 - 1966/04/07/ N1 - Accession Number: 84005096. Language: English. Entry Date: 20161119. Revision Date: 20161119. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562. KW - Architecture -- History KW - Public Figures KW - United States KW - History KW - Thornton, W SP - 790 EP - 791 JO - New England Journal of Medicine JF - New England Journal of Medicine JA - N ENGL J MED VL - 274 IS - 14 CY - Waltham, Massachusetts PB - New England Journal of Medicine SN - 0028-4793 AD - Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA U2 - PMID: 17926889. DO - 10.1056/NEJM196604072741410 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=84005096&site=ehost-live&scope=site DP - EBSCOhost DB - rzh ER - TY - GEN AU - Frome, Julius T1 - The effects of information storage and retrieval techniques and computers on problems of patentability JO - Journal of Chemical Documentation JF - Journal of Chemical Documentation Y1 - 1966/05// VL - 6 IS - 2 M3 - Article SP - 66 EP - 71 SN - 00219576 AB - The problems of the effect of information storage and retrieval techniques on patentability are discussed in relation to five areas: computer printouts as 'printed publications'; the implications of computer manipulations of structural formulas and chemical groups; the implications of indexing instructions and code sheets as suggesting combinations to a person skilled in the art; and composition or superimposed random coding interpreted as a reference. Possible solutions to the problems are indicated in relation to quoted judicial decisions. N1 - Accession Number: ISTA0100197; Frome, Julius 1; Affiliations: 1 : National Institute Of Mental Health; Source Info: May 1966, Vol. 6 Issue 2, p66; Note: Update Code: 0100; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0100197&site=ehost-live&scope=site DP - EBSCOhost DB - lih ER - TY - JOUR AU - Weiss, George H. T1 - THE INTERSECTION DELAY PROBLEM WITH CORRELATED GAP ACCEPTANCE. JO - Operations Research JF - Operations Research Y1 - 1966/07//Jul/Aug66 VL - 14 IS - 4 M3 - Article SP - 614 PB - INFORMS: Institute for Operations Research SN - 0030364X AB - This paper considers a modification of the single-car intersection delay problem in which the waiting driver, upon finding a suitable gap for crossing also examines the succeeding one, and uses it if it is larger. It is shown that the additional delay time caused by this method of gap acceptance is generally quite small. [ABSTRACT FROM AUTHOR] AB - Copyright of Operations Research is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - AUTOMOBILES KW - COMMUTING KW - OPERATIONS research KW - TRAFFIC flow KW - AUTOMOBILE drivers KW - LOCOMOTION KW - MOTOR vehicles KW - AUTOMOTIVE transportation N1 - Accession Number: 6700762; Weiss, George H. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland.; Issue Info: Jul/Aug66, Vol. 14 Issue 4, p614; Thesaurus Term: AUTOMOBILES; Thesaurus Term: COMMUTING; Thesaurus Term: OPERATIONS research; Subject Term: TRAFFIC flow; Subject Term: AUTOMOBILE drivers; Subject Term: LOCOMOTION; Subject Term: MOTOR vehicles; Subject Term: AUTOMOTIVE transportation; NAICS/Industry Codes: 336110 Automobile and light-duty motor vehicle manufacturing; NAICS/Industry Codes: 415110 New and used automobile and light-duty truck merchant wholesalers; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 811121 Automotive Body, Paint, and Interior Repair and Maintenance; NAICS/Industry Codes: 811198 All Other Automotive Repair and Maintenance; NAICS/Industry Codes: 441110 New Car Dealers; NAICS/Industry Codes: 336111 Automobile Manufacturing; NAICS/Industry Codes: 415190 Recreational and other motor vehicles merchant wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 488490 Other Support Activities for Road Transportation; Number of Pages: 5p; Illustrations: 1 Graph; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=6700762&site=ehost-live&scope=site DP - EBSCOhost DB - buh ER - TY - JOUR ID - 2013-41941-005 AN - 2013-41941-005 AU - Shore, Milton F. AU - Massimo, Joseph L. T1 - Comprehensive vocationally oriented psychotherapy for adolescent delinquent boys: A follow-up study. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/07// VL - 36 IS - 4 SP - 609 EP - 615 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 AD - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard, E., Adelphi, MD, US, 20783 N1 - Accession Number: 2013-41941-005. PMID: 5936765 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Program Development; Psychotherapy. Minor Descriptor: Occupational Guidance; Socioeconomic Status. Classification: Criminal Behavior & Juvenile Delinquency (3236); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1966. AB - A follow-up study of the adolescent delinquent boys participating in a new comprehensive, vocationally-oriented psychotherapy program reported earlier revealed that two to three years following termination the treated boys continued to show major improvement in ego functioning, though at a slower rate than during treatment. An untreated group deteriorated during that time. The results are of significance in planning programs of intervention, especially with lower socioeconomic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - vocationally oriented psychotherapy programs KW - adolescent delinquent boys KW - lower socioeconomic groups KW - program planning KW - 1966 KW - Juvenile Delinquency KW - Male Delinquency KW - Program Development KW - Psychotherapy KW - Occupational Guidance KW - Socioeconomic Status KW - 1966 U1 - Sponsor: Harvard University, Center for Research and Development in Educational Differences, US. Recipients: No recipient indicated DO - 10.1111/j.1939-0025.1966.tb02312.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-41941-010 AN - 2013-41941-010 AU - Rae-Srant, Quentin A. F. AU - Gladwin, Thomas AU - Bower, Eli M. T1 - Mental health, social competence and the war on poverty. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/07// VL - 36 IS - 4 SP - 652 EP - 664 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-41941-010. Partial author list: First Author & Affiliation: Rae-Srant, Quentin A. F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Leadership; Poverty; Social Skills; Social Skills Training; War. Minor Descriptor: Cognitive Processes; Mental Health. Classification: Social Processes & Social Issues (2900). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Jul, 1966. AB - Mental health has emphasized reduction of intrapsychic conflict. Increasingly intervention strategies are shifting toward cognitive training for social competence. This trend is traced back to the New Deal and early psychoanalysts. Mental health must reexamine its own strategies if it is to retain leadership within the helping professions. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - mental health KW - social competence KW - war KW - poverty KW - cognitive training KW - leadership KW - 1966 KW - Leadership KW - Poverty KW - Social Skills KW - Social Skills Training KW - War KW - Cognitive Processes KW - Mental Health KW - 1966 DO - 10.1111/j.1939-0025.1966.tb02317.x UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-010&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR ID - 2013-41941-030 AN - 2013-41941-030 AU - Flint, Arden A. Jr. T1 - Review of The psychotherapies of marital disharmonies. JF - American Journal of Orthopsychiatry JO - American Journal of Orthopsychiatry JA - Am J Orthopsychiatry Y1 - 1966/07// VL - 36 IS - 4 SP - 757 EP - 758 CY - US PB - American Orthopsychiatric Association, Inc. SN - 0002-9432 SN - 1939-0025 N1 - Accession Number: 2013-41941-030. Partial author list: First Author & Affiliation: Flint, Arden A. Jr.; Child Research Branch, National Institute for Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Marital Conflict; Marriage; Psychotherapy; Relationship Quality. Minor Descriptor: Collaboration. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Greene, Bernard L. (Ed). The psychotherapies of marital disharmonies=New York: The Free Press, 191 pp. $7.95; 1965. Page Count: 2. Issue Publication Date: Jul, 1966. AB - Reviews the book, The psychotherapies of marital disharmonies edited by Bernard L. Greene (1965). The trouble with humanity, some say, is the conflict between instinct and civilization. Others would point to the period of early dependency. The contributors to this hook might suggest a third possibility monogamy- as the basis of our discontent. There is much fog in this book but a few lights manage to shine through. Ackerman makes therapy sound like an adventure, which it can be, and his exploratory questions about the marriage are simple and appropriate. Grotjahn reveals unusual flexibility and humility in his moving description of his work with a family over four years. His admiration for the mother is refreshingly human. Satir crystallizes the central dilemma of marriage when she poses the question of how two people can agree on the same decision and still make room for the uniqueness of each. And Martin and Bird's friendship, described as a collaborative relationship, shows remarkable candor. The forthrightness they have with each other could serve as a model for all relationships, including marriage (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - psychotherapy KW - marital disharmonies KW - relationships status KW - marriage KW - collaborative relationship KW - 1966 KW - Marital Conflict KW - Marriage KW - Psychotherapy KW - Relationship Quality KW - Collaboration KW - 1966 U2 - Greene, Bernard L. (Ed). (1965); The psychotherapies of marital disharmonies; New York: The Free Press, 191 pp. $7.95 DO - 10.1037/h0098721 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41941-030&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Pearlin, Leonard I. AU - Kohn, Melvin L. T1 - SOCIAL CLASS, OCCUPATION, AND PARENTAL VALUES: A CROSS-NATIONAL STUDY. JO - American Sociological Review JF - American Sociological Review Y1 - 1966/08// VL - 31 IS - 4 M3 - Article SP - 466 EP - 479 SN - 00031224 AB - Despite the considerable difference between Italian and American parents' values for their children, social class is related to parental values in much the same way in both countries. Middle-class parents in both Italy and the United States are more likely to value the child's self-direction, working-class parents the child's conformity to external proscription. Three aspects of occupation - the closeness of supervision to which a man is subjected; whether he works principally with things, with people, or with ideas; and the degree of self-reliance his job requires - are each related to parents' values for their children. Together they account for a large part of the difference between middle- and working-class parents' values, especially for fathers. [ABSTRACT FROM AUTHOR] AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - SOCIAL classes KW - OCCUPATIONS KW - VALUES KW - MIDDLE class KW - PARENTING KW - INFLUENCE (Psychology) KW - FAMILIES KW - ITALY KW - UNITED States KW - Values (parental) N1 - Accession Number: 12768487; Pearlin, Leonard I. 1; Kohn, Melvin L. 1; Affiliations: 1 : National Institute of Mental Health; Source Info: Aug66, Vol. 31 Issue 4, p466; Historical Period: 1966; Subject Term: SOCIAL classes; Subject Term: OCCUPATIONS; Subject Term: VALUES; Subject Term: MIDDLE class; Subject Term: PARENTING; Subject Term: INFLUENCE (Psychology); Subject Term: FAMILIES; Subject: ITALY; Subject: UNITED States; Number of Pages: 14p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=12768487&site=ehost-live&scope=site DP - EBSCOhost DB - ahl ER - TY - JOUR AU - Myers, J. AU - Frei, J. V. AU - Cohen, J. J. AU - Rose, B. AU - Richter, M. T1 - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions. JO - Immunology JF - Immunology Y1 - 1966/08// VL - 11 IS - 2 M3 - Article SP - 155 EP - 162 SN - 00192805 AB - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR] AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) KW - BASAL lamina KW - IMMUNE serums KW - TISSUES KW - SODIUM hydroxide KW - IMMUNOGLOBULINS KW - RABBITS as laboratory animals KW - ANTIGENS N1 - Accession Number: 13284172; Myers, J. 1; Frei, J. V. 2; Cohen, J. J. 3,4; Rose, B. 3,4; Richter, M. 5; Source Information: Aug66, Vol. 11 Issue 2, p155; Subject: BASAL lamina; Subject: IMMUNE serums; Subject: TISSUES; Subject: SODIUM hydroxide; Subject: IMMUNOGLOBULINS; Subject: RABBITS as laboratory animals; Subject: ANTIGENS; Number of Pages: 9p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=13284172&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR ID - 2005-10692-005 AN - 2005-10692-005 AU - Ryder, Robert G. T1 - A Clerically Simple Procedure for Coding Interview Materials. JF - American Psychologist JO - American Psychologist JA - Am Psychol Y1 - 1966/08// VL - 21 IS - 8 SP - 812 EP - 812 CY - US PB - American Psychological Association SN - 0003-066X SN - 1935-990X N1 - Accession Number: 2005-10692-005. Partial author list: First Author & Affiliation: Ryder, Robert G.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Data Collection; Data Processing; Interviews; Methodology. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Interview. Page Count: 1. Issue Publication Date: Aug, 1966. Copyright Statement: American Psychological Association. 1966. AB - Work at the Child Research Branch presently includes the application of several thousand (binary) content codes to interview typescripts. The expectable complexities of doing the coding and having the resulting data transcribed accurately for keypunching purposes can easily be imagined. The present procedure, however, virtually eliminates clerical errors, because it virtually eliminates purely clerical operations. (PsycINFO Database Record (c) 2016 APA, all rights reserved) KW - content codes KW - interview typescripts KW - coding procedure KW - clerical error reduction KW - 1966 KW - Data Collection KW - Data Processing KW - Interviews KW - Methodology KW - 1966 DO - 10.1037/h0021033 UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10692-005&site=ehost-live&scope=site DP - EBSCOhost DB - psyh ER - TY - JOUR AU - Mergenhagen, S. E. AU - Notkins, A. L. AU - Evans, R. T. T1 - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies. JO - Immunology JF - Immunology Y1 - 1966/09// VL - 11 IS - 3 M3 - Article SP - 223 EP - 228 SN - 00192805 AB - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies. KW - GAMMA globulins KW - IMMUNOGLOBULINS KW - AGGLUTINATION of blood KW - IMMUNE serums KW - ERYTHROCYTES KW - ANTIGEN-antibody reactions N1 - Accession Number: 14578238; Mergenhagen, S. E.; Notkins, A. L. 1; Evans, R. T. 1; Source Information: Sep66, Vol. 11 Issue 3, p223; Subject: GAMMA globulins; Subject: IMMUNOGLOBULINS; Subject: AGGLUTINATION of blood; Subject: IMMUNE serums; Subject: ERYTHROCYTES; Subject: ANTIGEN-antibody reactions; Number of Pages: 6p; Document Type: Article UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=14578238&site=ehost-live&scope=site DP - EBSCOhost DB - hch ER - TY - JOUR AU - Cornfield, Jerome T1 - A BAYESIAN TEST OF SOME CLASSICAL HYPOTHESES-WITH APPLICATIONS TO SEQUENTIAL CLINICAL TRIALS. JO - Journal of the American Statistical Association JF - Journal of the American Statistical Association Y1 - 1966/09// VL - 61 IS - 315 M3 - Article SP - 577 SN - 01621459 AB - Consider someone who sets out to collect data sequentially in such a way as to disprove a hypothesis, H0, about the value of θ, the mean of a normal distribution. Observation is continued as long as the posterior probability of H0 exceeds ai and stopped when it falls below it. It is shown that if a non-zero prior probability, p, is assigned to H0(0≤α1α1 and P(θ>0) <α2 and stopping when either inequality is infringed, where Δ is the smallest positive departure from H0 of substantive interest and α1 <α2. Approximating the likelihood function for the logit of a binomial parameter with a normal likelihood function it is possible to extend these methods to the comparison of two binomial parameters, without the usual sequential assumption of pairing and equal number of cases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BAYESIAN analysis
KW - GAUSSIAN distribution
KW - PROBABILITY theory
KW - SAMPLING (Statistics)
KW - CLINICAL trials
KW - HYPOTHESIS
KW - LOGITS
N1 - Accession Number: 4606534; Cornfield, Jerome 1; Affiliations: 1: National Institutes of Health.; Issue Info: Sep66, Vol. 61 Issue 315, p577; Thesaurus Term: BAYESIAN analysis; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: PROBABILITY theory; Thesaurus Term: SAMPLING (Statistics); Subject Term: CLINICAL trials; Subject Term: HYPOTHESIS; Subject Term: LOGITS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 18p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Mantel, Nathan
AU - Pasternack, Bernard S.
T1 - LIGHT BULB STATISTICS.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1966/09//
VL - 61
IS - 315
M3 - Article
SP - 633
SN - 01621459
AB - Using the concept of an idealized light bulb, one subject to a constant probability of failure while in use, certain distribution problems are solved heuristically. These include: (1) The distribution of sums, or differences, of products of pairs of independent standard normal deviates; (2) The distribution of the difference of 2 chi squares, each with even degrees of freedom or, equivalently, the difference between 2 total waiting times; (3) The distribution of the ratio of 2 chi squares, each with even degrees of freedom or, equivalently, the ratio of 2 total waiting times; (4) Distributions arising in a simple exponential growth process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - HEURISTIC
KW - PROBABILITY theory
KW - UNIFORM distribution (Probability theory)
KW - FAILURE time data analysis
KW - LIGHT bulbs
KW - CHI-squared test
N1 - Accession Number: 4606637; Mantel, Nathan 1; Pasternack, Bernard S. 2; Affiliations: 1: Biometry Branch, National Cancer Institute.; 2: Institute of Environmental Medicine, New York University Medical Center.; Issue Info: Sep66, Vol. 61 Issue 315, p633; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: HEURISTIC; Thesaurus Term: PROBABILITY theory; Subject Term: UNIFORM distribution (Probability theory); Subject Term: FAILURE time data analysis; Subject Term: LIGHT bulbs; Subject Term: CHI-squared test; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; NAICS/Industry Codes: 416110 Electrical wiring and construction supplies merchant wholesalers; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; NAICS/Industry Codes: 335110 Electric Lamp Bulb and Part Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rosenberg, Morris
T1 - Self and Society: Social Change and Individual Development (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1966/10//
VL - 31
IS - 5
M3 - Book Review
SP - 746
EP - 747
SN - 00031224
AB - Reviews the book "Self and Society: Social Change and Individual Development," by Nevitt Sanford.
KW - SOCIAL change
KW - NONFICTION
KW - SANFORD, Nevitt
KW - SELF & Society (Book)
N1 - Accession Number: 12785708; Rosenberg, Morris 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Oct66, Vol. 31 Issue 5, p746; Thesaurus Term: SOCIAL change; Subject Term: NONFICTION; Reviews & Products: SELF & Society (Book); People: SANFORD, Nevitt; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - Gen
ID - 9999-05710-000
AN - 9999-05710-000
AU - Feld, Sheila C.
T1 - Adolescent Maternal Practices Check List
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1967///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1 - Accession Number: 9999-05710-000. Partial author list: First Author & Affiliation: Feld, Sheila C.; National Institute of Mental Health, Mental Health Study Center, Adelphi, Maryland, United States. Release Date: 20111010. Correction Date: 20151109. Instrument Type: Checklist. Test Format: Items are rated on a 6-point rating scale.. Language: English. Constructs: Maternal Encouragement; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Adolescent Maternal Practices Check List is to assess maternally encouraged independent accomplishment and mastery in their sons.
AB - Description: The Adolescent Maternal Practices Check List (Feld, 1967) was developed within the context of a study that attempted to clarify the issue of the relationship between certain childhood experiences and achievement motive in adolescence in males. Winterbottom (1953) found a positive relationship between the n Achievement of boys at ages 8-10 and their mothers' attitudes toward independent accomplishment. This Adolescent Maternal Practices Check List was designed to tap both the achievement and independence dimensions that had been included in Winterbottom's assessment of earlier maternal attitudes toward independent accomplishment (Childhood Maternal Practices Check List). The items of the Adolescent Maternal Practices Check List were designated, on an a priori basis, as being primarily involved with independence, achievement, or behaviors unrelated to independence or achievement attitudes (filler items). The a priori achievement and independence subscales were refined by item analysis. The final achievement subscale consisted of 12 items and the independence subscale of 16 items. The mean of the replies to all items in each subscale was the score on that subscale, with higher scores indicating more encouragement of that set of behaviors. The correlation between the achievement and independence subscales was .56 (p < .01). Consistency over time of maternal attitudes was assessed by comparing the measures obtained from mothers when their sons were adolescents with the reports made to Winterbottom 6 years earlier (N = 17). There was no significant relationship between either of the adolescent maternal attitude subscales and the Childhood Maternal Practices Check List. The direction of the correlations suggested a reversal of maternal attitudes (r = —.39 for the independence subscale and r= —.36 for the achievement subscale); that is, the earlier a mother demanded independent accomplishment from her grade-school- aged son, the less she tended to encourage independence or achievement in her child at adolescence. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Adolescent Maternal Practices Check List
KW - Mother Child Relations
KW - Parental Attitudes
KW - Parental Role
KW - Test Development
U5 - Adolescent Maternal Practices Check List [Test Development]LONGITUDINAL STUDY OF THE ORIGINS OF ACHIEVEMENT STRIVINGS. (AN: 1968-03775-001 from PsycINFO) FELD, SHEILA C.; Dec, 1967. Source: Journal of Personality and Social Psychology. 7(4, Pt.1), American Psychological Association, US; Dec, 1967; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: High School Males and Their Mothers Keywords: Adolescent Maternal Practices Check List; Mother Child Relations; Parental Attitudes; Parental Role; Test Development; Subjects: Mother Child Relations; Parental Attitudes; Parental Role; Test Construction;
DO - 10.1037/t05710-000
L3 - Full; Full text; 999905710_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-18191-000
AN - 9999-18191-000
AU - Raskin, Allen
AU - Schulterbrandt, Joy
AU - Reatig, Natalie
AU - Rice, Charles E.
T1 - Inventory of Psychic and Somatic Complaints
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1967///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-18191-000. Other Names: Inventory of Psychic and Somatic Complaints (Patient); Inventory of Psychic and Somatic Complaints (Psychiatrist). Acronyms: IPSC; IPSC (Patient); IPSC (Psychiatrist). Partial author list: First Author & Affiliation: Raskin, Allen; National Institute of Mental Health, United States. Release Date: 20130408. Correction Date: 20160808. Instrument Type: Inventory/Questionnaire. Test Location: Table 1 & 2, Page 272. Test Format: The Inventory of Psychic and Somatic Complaints (psychiatrist) utilizes 7-point degree-of-discomfort scales. The Inventory of Psychic and Somatic Complaints (patient) employs 4-point intensity scales.. Language: English. Constructs: Psychopathology; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Inventory of Psychic and Somatic Complaints is to assess symptoms of psychopathology.
AB - Description: The Inventory of Psychic and Somatic Complaints (IPSC; Raskin et al., 1967) was developed to assess symptoms of psychopathology. This measure is a modification of the Symptom Distress Scale (Frank et al., 1957) with additional items sampling secondary symptoms of depression. Two forms of the IPSC were created--a psychiatrist-rated version and a patient-rated version. The IPSC (psychiatrist) consists of 41 items, whereas the IPSC (patient) contains 53 items. The 12 additional items in the patient IPSC, as compared to the psychiatrist IPSC, are mainly specific somatic complaints. Factor analysis with Varimax rotation yielded six factors for the IPSC (psychiatrist): Anergia, Hostility, Loss of esteem, Guilt, Anxiety-phobic reactions, and Sleep disturbance. Seven factors were extracted for the IPSC (patient): Anxious depression, Hostility, Morbid obsession, Concomitants of anxiety, Sleep disturbance, Hysteria, and Gastrointestinal and muscular complaints. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Test Development
KW - Inventory of Psychic and Somatic Complaints
KW - Test Validity
KW - Anergia
KW - Hostility
KW - Loss of Esteem
KW - Guilt
KW - Anxiety-Phobic Reactions
KW - Sleep Disturbance
KW - Anxious Depression
KW - Morbid Obsession
KW - Concomitants of Anxiety
KW - Hysteria
KW - Gastrointestinal and Muscular Complaints
U5 - Inventory of Psychic and Somatic Complaints (IPSC, IPSC (Patient), IPSC (Psychiatrist)) [Test Development]Factors of Psychopathology in Interview, Ward Behavior, and Self-Report Ratings of Hospitalized Depressives. (AN: 2005-10657-003 from PsycINFO) Raskin, Allen; Schulterbrandt, Joy; Reatig, Natalie; Rice, Charles E.; Jun, 1967. Source: Journal of Consulting Psychology. 31(3), American Psychological Association, US; Jun, 1967; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Inpatient; Sample: Hospitalized Depressed Patients Keywords: Test Development; Inventory of Psychic and Somatic Complaints; Test Validity; Anergia; Hostility; Loss of Esteem; Guilt; Anxiety-Phobic Reactions; Sleep Disturbance; Anxious Depression; Morbid Obsession; Concomitants of Anxiety; Hysteria; Gastrointestinal and Muscular Complaints; Subjects: Anxiety; Factor Analysis; Guilt; Hostility; Hysteria; Major Depression; Obsessions; Physical Disorders; Self-Esteem; Sleep Disorders; Test Construction; Test Validity;
DO - 10.1037/t18191-000
L3 - Partial; Full text; 999918191_partial_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Liederman, Captain Paul C.
AU - Green, Richard
AU - Liederman, Veronica R.
T1 - Outpatient group therapy with geriatric patients.
JO - Geriatrics
JF - Geriatrics
Y1 - 1967/01//
VL - 22
IS - 1
M3 - Article
SP - 148
EP - 153
SN - 0016867X
N1 - Accession Number: 17184685; Liederman, Captain Paul C. 1; Green, Richard 2; Liederman, Veronica R.; Source Information: Jan1967, Vol. 22 Issue 1, p148; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 2184
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Oppenheim, J. J.
AU - Wolstencroft, R. A.
AU - Gell, P. G. H.
T1 - Delayed Hypersensitivity in the Guinea-Pig to a Protein-Hapten Conjugate and its Relationship to in vitro Transformation of Lymph Node, Spleen, Thymus and Peripheral Blood Lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1967/01//
VL - 12
IS - 1
M3 - Article
SP - 89
EP - 102
SN - 00192805
AB - Guinea-pig delayed hypersensitivity to purified protein derivative (PPD) and guinea-pig albumin-orthanilic acid (AO) was produced in the absence of detectable antibody formation to the conjugate. Ten days after sensitization the guinea-pig peripheral leucocytes, lymph nodes, spleen and thymus cell suspensions were cultured from 1 to 5 days with various concentrations of immunizing antigens, unconjugated hapten, a hapten—ovalbumin conjugate or phytohaemagglutinin (PHA). All the cultures of ‘draining’ lymph node cells, and about 40 per cent of the spleen and peripheral leucocyte cultures manifested increased lymphocyte transformation on radioautographs, and by total tritiated thymidine incorporation when stimulated by PPD or AO. In addition all the cultures responded well to PHA. However, lymphocytes from the mediastinal and cervical lymph nodes from the immunized, and most of the lymphoid organ cultures from unimmunized guinea-pigs were not stimulated by antigens but responded only to PHA. Cultured guinea-pig thymocytes did not respond to any stimulus. The in vitro lymphocyte proliferation was carrier specific. It did not occur in response to unconjugated hapten. However, the response to AO was partially inhibited in the presence of the hapten. The in vitro kinetics and morphological changes in the cultures also were investigated, and the immunological significance and specificity of lymphocyte transformation are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINS
KW - PROTEINS
KW - LEUCOCYTES
KW - KILLER cells
KW - BLOOD cells
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGY
N1 - Accession Number: 13320964; Oppenheim, J. J. 1; Wolstencroft, R. A. 2; Gell, P. G. H. 2; Source Information: Jan67, Vol. 12 Issue 1, p89; Subject: ALBUMINS; Subject: PROTEINS; Subject: LEUCOCYTES; Subject: KILLER cells; Subject: BLOOD cells; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGY; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1968-13455-001
AN - 1968-13455-001
AU - Bailar, John C.
AU - Gurian, Joan
T1 - The medical significance of date of birth.
JF - Eugenics Quarterly
JO - Eugenics Quarterly
Y1 - 1967///
VL - 14
IS - 2
SP - 89
EP - 102
CY - US
PB - Society for the Study of Social Biology
N1 - Accession Number: 1968-13455-001. PMID: 6063168 Other Journal Title: Biodemography and Social Biology. Partial author list: First Author & Affiliation: Bailar, John C.; National Institutes of Health. Release Date: 19680101. Correction Date: 20161229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Birth; Genetics. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Page Count: 14. Issue Publication Date: 1967.
AB - CONCLUDES THAT THERE IS CLEAR EVIDENCE OF MONTH TO MONTH VARIATION IN INFANT MORTALITY AND IN THE OCCURRENCE OF SOME CONGENITAL MALFORMATIONS SUCH AS ANENCEPHALY, PATENT DUCTUS ARTERIOSUS, AND CONGENITAL DISLOCATION OF THE HIP. FURTHER COLLECTING OF SUCH DATA IS USELESS. INSTEAD, TO PERMIT INTERPRETATION, THE SEX RATIO SHOULD BE CHECKED AND MORE IMPORTANTLY SEASONAL VARIATION IN NOXIOUS STIMULI INVESTIGATED. DIFFERENCES IN ABILITY AMONG PERSONS BORN IN CERTAIN MONTHS ARE MENTIONED AS AN EXAMPLE IN NEED OF FINDING THAT KIND OF EXPLANATION. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MONTH OF BIRTH & INFANT MORTALITY & CONGENITAL MALFORMATIONS
KW - 1967
KW - Birth
KW - Genetics
KW - 1967
DO - 10.1080/19485565.1967.9987708
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Haenszel, William
T1 - CONCEPT, MEASUREMENT, AND DATA IN MIGRATION ANALYSIS.
JO - Demography
JF - Demography
Y1 - 1967/02//
VL - 4
IS - 1
M3 - Article
SP - 253
EP - 261
SN - 00703370
AB - Two methods of computing migration rates-one relating moves to population at risk in place of origin and the other using as a denominator the cross-product of population in. places of origin and destination-are discussed. It is concluded that the second assumes implicitly that moves originate and terminate as a random population variable. Some difficulties with this particular model are pointed out and the author suggests that other analytical approaches to migration data be sought and in this connection refers to the literature on the mathematical theory of epidemics. (English) [ABSTRACT FROM AUTHOR]
AB - Se discute dos métodos para computar tasas de migración, uno relaciona el desplazamiento con la problación sometida al riesgo en el lugar de origen y el otro que usa como denominador el producto cruzado de la población en los lugares de origen y de destino. Se concluye que el segundo asume implicitamente que los desplazamientos se originan y terminan como una variable poblacional fortuita. Se señalan algunas dificultades con este modelo particular y el autor sugiere que deben buscarse otras perspectivas analiticas para tratar datos sobre migración y en conección con esto se refiere a la literatura sobre la teoria matemática de las epidemias. (Spanish) [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMIGRATION & immigration
KW - DEMOGRAPHY
KW - EPIDEMICS
KW - THEORY
KW - POPULATION
KW - EPIDEMIOLOGY
N1 - Accession Number: 16810042; Haenszel, William 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland.; Issue Info: Feb1967, Vol. 4 Issue 1, p253; Thesaurus Term: EMIGRATION & immigration; Thesaurus Term: DEMOGRAPHY; Subject Term: EPIDEMICS; Subject Term: THEORY; Subject Term: POPULATION; Subject Term: EPIDEMIOLOGY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Weiss, George H.
T1 - The Theory of Road Traffic Flow (Book).
JO - Transportation Science
JF - Transportation Science
Y1 - 1967/02//
VL - 1
IS - 1
M3 - Book Review
SP - 47
PB - INFORMS: Institute for Operations Research
SN - 00411655
AB - Reviews the book "The Theory of Road Traffic Flow," by Winifred D. Ashton.
KW - TRAFFIC flow
KW - NONFICTION
KW - ASHTON, Winifred
KW - ASHTON, Winifred D.
KW - THEORY of Road Traffic Flow, The (Book)
N1 - Accession Number: 4471158; Weiss, George H. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; Issue Info: Feb67, Vol. 1 Issue 1, p47; Subject Term: TRAFFIC flow; Subject Term: NONFICTION; Reviews & Products: THEORY of Road Traffic Flow, The (Book); People: ASHTON, Winifred; People: ASHTON, Winifred D.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hall, William T.
AU - Claus, George
T1 - ULTRASTRUCTURAL STUDIES ON THE CYANELLES OF CLAUCOCYSTIS NOSTOCHINEARUM ITZIGSOHN.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1967/03//
VL - 3
IS - 1
M3 - Article
SP - 37
EP - 51
PB - Wiley-Blackwell
SN - 00223646
AB - Ultrastructural studies conducted on the intracellular symbiont of Glaucocystis nostochinearum Itz., a unicellular alga with a debated taxonomic position have shown that the endosymbiont, although somewhat aberrant, is a blue-green alga. Due possibly to its intracellular habitat, it lacks the characteristic cyanophycean double-layered cell wall and the cells appear to be completely naked, bound only by a single plasma membrane. The protoplasm of the cell is differentiated into the lamellated chromatoplasm, which contains the photosynthetic pigments and poly-phosphate granules, and a nonlamellar centroplasm, in winch the nucleic material is dispersed. The usual cyanophycean organelles, as well as the different vacuoles and granules, with the exception of the formed bodies, are missing. Approximately 10% of the cells shows a peculiar homogeneous area at one tip, nature of which is unknown. Binary fission the organism is mentioned. Since this cyanelle not yet been classified, we name it Skujapelta nuda nov. gen., nov. sp.; and because of its structural peculiarities we find it necessary to create a new family for it, Skujapeltaceae in the order Chroococcales. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Habitat (Ecology)
KW - Cell membranes
KW - Cells
KW - Biological pigments
KW - Paint materials
KW - Art materials
N1 - Accession Number: 11578700; Hall, William T. 1; Claus, George 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014.; 2: Graduate Department of Marine Science, Long Island University, Brookville; Issue Info: Mar1967, Vol. 3 Issue 1, p37; Thesaurus Term: Habitat (Ecology); Thesaurus Term: Cell membranes; Subject Term: Cells; Subject Term: Biological pigments; Subject Term: Paint materials; Subject Term: Art materials; NAICS/Industry Codes: 339940 Office Supplies (except Paper) Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Martin, Jess A
T1 - Medical library internship at nih
JO - Bulletin of the Medical Library Association
JF - Bulletin of the Medical Library Association
Y1 - 1967/04//
VL - 55
IS - 2
M3 - Article
SP - 207
EP - 208
SN - 00257338
AB - The intership program for medical librarians sponsored by the national institutes of health was begun in 1964 and was approved by the medical library association. The program ensures a 'planned and balanced development of ... Capabilities,' and' an intensified, systematic, and broad working knowledge and understanding of all phases of librarianship.' an outline of the program is provided.
N1 - Accession Number: ISTA0200239; Martin, Jess A 1; Affiliations: 1 : Library Branch, Division Of Reserch Services, National Institutes Of Health, Bethesda, Maryland; Source Info: April 1967, Vol. 55 Issue 2, p207; Note: Update Code: 0200; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Carrese, Louis M.
AU - Baker, Carl G.
T1 - THE CONVERGENCE TECHNIQUE: A METHOD FOR THE PLANNING AND PROGRAMMING OF RESEARCH EFFORTS.
JO - Management Science
JF - Management Science
Y1 - 1967/04//
VL - 13
IS - 8
M3 - Article
SP - B-420
EP - B-438
PB - INFORMS: Institute for Operations Research
SN - 00251909
AB - The difficulties encountered in attempts to apply directly some of the standard network analysis techniques to the planning of research programs are discussed. The particularized requirements for a planning system suitable for research efforts are identified, and a technique developed specifically for the planning and programming of research efforts is described. Basically, the technique involves the formulation of a series of flows and arrays depicting major program elements and individual projects, sequentially ordered on the basis of research logic, and graphically represented by a matrix which relates research performance to resources required (including personnel, materials, equipment and facilities, and funds). Because of the nature of research, the technique was developed to avoid the formulation of tight networks with sharp time-to-completion estimates for each project. The application of this technique to two biomedical research programs of the National Cancer Institute is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Management Science is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STOCHASTIC convergence
KW - NETWORK analysis (Planning)
KW - RESEARCH
KW - OPERATIONS research
KW - PRODUCTION scheduling
KW - PLANNING
KW - BUSINESS planning
KW - MEDICAL research
KW - MATRICES
KW - NETWORK analysis (Communication)
KW - UNITED States
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 7028113; Carrese, Louis M. 1; Baker, Carl G. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland.; Issue Info: Apr1967, Vol. 13 Issue 8, pB-420; Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: NETWORK analysis (Planning); Thesaurus Term: RESEARCH; Thesaurus Term: OPERATIONS research; Thesaurus Term: PRODUCTION scheduling; Thesaurus Term: PLANNING; Thesaurus Term: BUSINESS planning; Subject Term: MEDICAL research; Subject Term: MATRICES; Subject Term: NETWORK analysis (Communication); Subject: UNITED States ; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2005-09867-004
AN - 2005-09867-004
AU - Schooler, Carmi
AU - Tecce, Joseph J.
T1 - Verbal paired-associates learning in chronic schizophrenics as a function of positive and negative evaluation.
JF - Journal of Abnormal Psychology
JO - Journal of Abnormal Psychology
JA - J Abnorm Psychol
Y1 - 1967/04//
VL - 72
IS - 2
SP - 151
EP - 156
CY - US
PB - American Psychological Association
SN - 0021-843X
SN - 1939-1846
N1 - Accession Number: 2005-09867-004. PMID: 5623442 Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Schooler, Carmi; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Correction Date: 20151019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evaluation; Paired Associate Learning; Schizophrenia; Verbal Learning. Minor Descriptor: Negative Reinforcement; Positive Reinforcement. Classification: Clinical Psychological Testing (2224); Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Kent-Rosanoff Word Association Test; Rosenberg Self-Esteem Scale DOI: 10.1037/t01038-000; Wechsler Adult Intelligence Scale (WAIS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1967. Copyright Statement: American Psychological Association. 1967.
AB - Seventy-two chronic schizophrenics (36 regressed and 36 partially remitted) and 36 normals were given paired associates of 2 levels of association strength and 2 levels of intralist response competition to learn under positive, negative, and nonevaluation conditions. Regressed schizophrenics showed maximum decrement on low-association word pairs following positive evaluation. This was especially true for those Ss with low self-esteem. These findings suggest that heightened arousal resulting from dissonance between a negative self-image and positive evaluation of performance can lead to behavioral decrement in a difficult task requiring novel associations, such decrement being congruent with the Hull-Spence behavior theory and the Yerkes-Dodson hypothesis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - verbal paired-associates learning
KW - chronic schizophrenia
KW - positive evaluation
KW - negative evaluation
KW - 1967
KW - Evaluation
KW - Paired Associate Learning
KW - Schizophrenia
KW - Verbal Learning
KW - Negative Reinforcement
KW - Positive Reinforcement
KW - 1967
DO - 10.1037/h0020089
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09867-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10656-001
AN - 2005-10656-001
AU - Goldberg, Solomon C.
AU - Mattsson, Nils
T1 - Symptom changes associated with improvement in schizophrenia.
JF - Journal of Consulting Psychology
JO - Journal of Consulting Psychology
JA - J Consult Psychol
Y1 - 1967/04//
VL - 31
IS - 2
SP - 175
EP - 180
CY - US
PB - American Psychological Association
SN - 0095-8891
N1 - Accession Number: 2005-10656-001. PMID: 6042053 Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Goldberg, Solomon C.; National Institute of Mental Health, US. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 20060327. Correction Date: 20150119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Judgment (Not Diagnosis); Drug Therapy; Psychiatric Symptoms; Schizophrenia. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. Tests & Measures: Inpatient Multi-Dimensional Psychiatric Scale; Ward Behavior Rating Scale DOI: 10.1037/t29750-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1967. Copyright Statement: American Psychological Association. 1967.
AB - The present study shows that global, clinical judgments of improvement can be predicted by a linear combination of various elements of symptom reduction. This runs counter to the contention of Meehl (1950) that configural, nonlinear combinations are necessary to account for clinical judgment. Of some pragmatic value is the fact that the prediction equation can form the basis of a composite improvement score whose elements of symptom reduction are weighted according to their relationship to the clinically face-valid rating of improvement. This composite is shown to be highly consistent between various drug treatments and between study samples on the same drug treatment. Moreover, it is shown to be a more sensitive discriminator between drug- and placebo-treated patients. The composite is offered as a more sensitive measure of improvement in acute schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - symptom reduction
KW - clinical judgments of improvement
KW - symptom changes
KW - schizophrenia
KW - drug treatments
KW - 1967
KW - Clinical Judgment (Not Diagnosis)
KW - Drug Therapy
KW - Psychiatric Symptoms
KW - Schizophrenia
KW - 1967
DO - 10.1037/h0020995
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10656-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06065-017
AN - 2006-06065-017
AU - Dittmann, Aallen T.
T1 - Psychoanalysis to the Rescue.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1967/04//
VL - 12
IS - 4
SP - 202
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06065-017. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Dittmann, Aallen T.; Laboratory of Psychology, National Institute of Mental Health, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Motivation; Psychoanalysis; Social Sciences. Minor Descriptor: Interviewing; Psychoanalysts. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Hendin, Herbert; Gaylin, Willard; Carr, Arthur. Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient=New York: Doubleday, 1965. Pp. 106. $2.95; 1965. Page Count: 2. Issue Publication Date: Apr, 1967.
AB - Reviews the book, Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient by Herbert Hendin, Willard Gaylin, and Arthur Carr (see record [rid]1966-12441-000[/rid]). This modestly titled little volume purports to show that psychoanalytic methods of obtaining data can enrich the research carried on by social scientists. The authors find established social research methods wanting: in interviewing respondents' answers are taken at face value; in statistical and demographic material motivation is not taken into account; and in descriptions of social institutions the resulting characterizations miss the point of the effect of the institutions on the individual. Psychoanalysts should be able to rescue social research on all these points, the authors reason, and it remains only to learn if their interviewing techniques can be applied to normal people as well as to patients in order that psychoanalysis be firmly launched in the social sciences. Almost four-fifths of the pages of the book are devoted to these cases, the first one reported quite fully, the others condensed in varying degrees. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social research
KW - psychoanalysis
KW - demographic material motivation
KW - psychoanalytic methods
KW - 1967
KW - Motivation
KW - Psychoanalysis
KW - Social Sciences
KW - Interviewing
KW - Psychoanalysts
KW - 1967
U2 - Hendin, Herbert; Gaylin, Willard; Carr, Arthur. (1965); Psychoanalysis and Social Research: The Psychoanalytic Study of the Non-Patient; New York: Doubleday, 1965. Pp. 106. $2.95
DO - 10.1037/007746
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06065-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40223-016
AN - 2013-40223-016
AU - Rae-Grant, Quentin
T1 - Discussion: 'The influence of insurance carriers in determining professional practice: New battles but old wars'.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/04//
VL - 37
IS - 3
SP - 587
EP - 593
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40223-016. PMID: 6032949 Partial author list: First Author & Affiliation: Rae-Grant, Quentin; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Insurance; Mental Disorders; Mental Health Services. Minor Descriptor: Health Behavior; Program Development. Classification: Psychological Disorders (3210); Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1967.
AB - This article discusses, the field of mental health like the field of general health care, is going through a period of rapid and radical change that amounts to nothing less than a subrevolution. Because of the success that insurance and prepayment programs have had in mitigating the burden of financial expenditure for general health care, there has long been a push, particularly by professionals, for the extension of these plans to cover mental health problems. Thus, insurance coverage is part of the overall battle for more adequate general medical and mental health care for the total populace. Most insurance coverage for mental and emotional disorders is based on the assumptions inherent in the definitions quoted from the American Psychiatric Association's 'Guidelines.' To say that many psychiatrists, as well as psychologists and social workers, do not accept these assumptions is beside the point. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - insurance carriers
KW - prepayment program
KW - social workers
KW - mental health
KW - health care
KW - mental health services
KW - 1967
KW - Insurance
KW - Mental Disorders
KW - Mental Health Services
KW - Health Behavior
KW - Program Development
KW - 1967
DO - 10.1037/h0097254
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40223-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40223-031
AN - 2013-40223-031
AU - Wiener, Jack
T1 - Mental health highlights.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/04//
VL - 37
IS - 3
SP - 619
EP - 623
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40223-031. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Mental Health; Mental Health Programs; Public Sector. Minor Descriptor: Addiction; Laws; Narcosis. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 5. Issue Publication Date: Apr, 1967.
AB - The current article highlights the 'mental health' in the titles of any of the federal laws listed below. But each of the laws has some provision which makes it possible to expand mental health programs. It is hard to find common elements in the laws but the words that stand out in more than one law are : 'planning,' 'comprehensive health services,' 'the poor,' and 'narcotic addiction.' Even when it comes to getting their children into a public institution for the retarded, the well-to-do are more successful than the poor. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - mental health programs
KW - health services
KW - public institution
KW - narcotic addiction
KW - laws
KW - 1967
KW - Health Care Services
KW - Mental Health
KW - Mental Health Programs
KW - Public Sector
KW - Addiction
KW - Laws
KW - Narcosis
KW - 1967
DO - 10.1111/j.1939-0025.1967.tb00499.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40223-031&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ben-Efraim, S.
AU - Fuchs, Sara
AU - Sela, M.
T1 - Differences in Immune Response to Synthetic Antigens in Two Inbred Strains of Guinea-Pigs.
JO - Immunology
JF - Immunology
Y1 - 1967/05//
VL - 12
IS - 5
M3 - Article
SP - 573
EP - 581
SN - 00192805
AB - The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into three categories: (a) immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; (b) irnmunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and (c) immunogenic in strain 2 and negative in strain 13 : linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F1 hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.
KW - PEPTIDES
KW - TYROSINE
KW - GLUTAMIC acid
KW - ALANINE
KW - LYSINE
KW - COPOLYMERS
KW - OPTICAL isomers
KW - GUINEA pigs as laboratory animals
N1 - Accession Number: 13331987; Ben-Efraim, S. 1,2; Fuchs, Sara 1,2; Sela, M. 1,2; Source Information: May67, Vol. 12 Issue 5, p573; Subject: PEPTIDES; Subject: TYROSINE; Subject: GLUTAMIC acid; Subject: ALANINE; Subject: LYSINE; Subject: COPOLYMERS; Subject: OPTICAL isomers; Subject: GUINEA pigs as laboratory animals; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - CONF
AU - Cosmides, George J.
AU - Rall, David P.
T1 - International Symposium on Comparative Pharmacology.
JO - BioScience
JF - BioScience
Y1 - 1967/06//
VL - 17
IS - 6
M3 - Proceeding
SP - 413
EP - 416
SN - 00063568
AB - The article offers information on the International Symposium on Comparative Pharmacology that took place in Washington D.C. during January 24-27, 1967. The symposium made known areas of research in which the techniques of various disciplines can be employed, species new to laboratory investigation. The members for the Program Planning Committee for the symposium include chairman E.J. Cafruny of the University of Minnesota, G.J. Cosmides of the National Institute of General Medical Sciences.
KW - Conferences & conventions
KW - Pharmacology -- Congresses
KW - Washington (D.C.)
KW - Cafruny, E. J.
KW - Cosmides, G. J.
N1 - Accession Number: 31990883; Cosmides, George J. 1; Rall, David P. 1; Affiliations: 1 : National Institutes of Health, Bethesda, Maryland.; Source Info: Jun1967, Vol. 17 Issue 6, p413; Subject Term: Conferences & conventions; Subject Term: Pharmacology -- Congresses; Subject: Washington (D.C.); Number of Pages: 4p; Document Type: Proceeding
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Dittmann, Allen T.
AU - Lynn, D.
AU - Llewellyn, G.
T1 - THE PHONEMIC CLAUSE AS A UNIT OF SPEECH DECODING.
JO - Journal of Personality & Social Psychology
JF - Journal of Personality & Social Psychology
Y1 - 1967/07//
VL - 6
IS - 3
M3 - Article
SP - 341
EP - 349
SN - 00223514
AB - It is argued here that spoken language is decoded by the listener in word groups called phonemic clauses. Behavioral data, the location of listener responses in relation to the speaker's phonemic clauses, provide the evidence. Pairs of Ss spoke to each other alternately on topics of mutual interest in a situation resembling that of a telephone conversation. The listeners were instructed to let the speakers know that they were listening and interested. Their responses were found to be located almost exclusively at the ends of the speakers' phonemic clauses rather than within them, whether or not there were hesitations at either point. Further, only those types of clause ending which sound most "final" were followed by listener responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality & Social Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Phonemics
KW - Language & languages
KW - Speech
KW - Behavioral assessment
KW - Conversation
KW - Oral communication
N1 - Accession Number: 16688755; Dittmann, Allen T. 1; Lynn, D. 1; Llewellyn, G. 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: Jul67, Vol. 6 Issue 3, p341; Thesaurus Term: Phonemics; Thesaurus Term: Language & languages; Thesaurus Term: Speech; Thesaurus Term: Behavioral assessment; Thesaurus Term: Conversation; Thesaurus Term: Oral communication; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 2006-06102-009
AN - 2006-06102-009
AU - Yarrow, Leon J.
T1 - In Need of Theory.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1967/07//
VL - 12
IS - 7
SP - 347
EP - 348
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06102-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior Change; Child Care; Childhood Development; Recovery (Disorders). Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Flint, Betty M. The Child and the Institution: A Study of Deprivation and Recovery=Ontario, Canada: University of Toronto Press, 1966. Pp. xii + 177. $7.50; 1966. Page Count: 2. Issue Publication Date: Jul, 1967.
AB - Reviews the book, The Child and the Institution: A Study of Deprivation and Recovery by Betty M. Flint (see record [rid]1966-06769-000[/rid]). At a time when we are seeking new models of childcare, particularly for children whose parents are absent or inadequate, this account of an effort to institute radical changes in a traditional child care institution is especially interesting. Several chapters in the present book consist of detailed case histories of children from the time of entrance into the institution through the period following the change. These case discussions do not add much depth to our understanding of the changes which occurred since the descriptions of the children are restricted to the terms of the rating scales. There is little attempt to integrate the case data in terms of concepts at a higher order of complexity than those contained in the rating scales. A number of important theoretical issues are hinted at, but never fully developed. There are some suggestions that the behavioral changes observed in the children might have been situational rather than at a deep characterological level. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - deprivation
KW - recovery
KW - children
KW - behavioral changes
KW - 1967
KW - Behavior Change
KW - Child Care
KW - Childhood Development
KW - Recovery (Disorders)
KW - 1967
U2 - Flint, Betty M. (1966); The Child and the Institution: A Study of Deprivation and Recovery; Ontario, Canada: University of Toronto Press, 1966. Pp. xii + 177. $7.50
DO - 10.1037/009187
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06102-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40696-011
AN - 2013-40696-011
AU - Wender, Paul H.
AU - Pedersen, Frank A.
AU - Waldrop, Mary F.
T1 - A longitudinal study of early social behavior and cognitive development.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/07//
VL - 37
IS - 4
SP - 691
EP - 696
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40696-011. PMID: 6033423 Partial author list: First Author & Affiliation: Wender, Paul H.; National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1966, San Francisco, CA, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Cognitive Ability; Cognitive Development; Cognitive Style; Nursery Schools; Social Behavior. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Tests & Measures: Wechsler Intelligence Scale for Children-Short Form; Children's Embedded Figures Test. Methodology: Empirical Study; Followup Study; Longitudinal Study; Interview; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1967.
AB - Thirty boys who had been studied in a research nursery school when they were two and a half were re-evaluated when they were six and a half. Early social differences tended to correlate with later intellectual ones; children who were socially dependent in nursery school tended to show a less abstract cognitive style and lower nonverbal intellectual functioning when older. Four cases are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - early social behavior
KW - cognitive development
KW - nursery schools
KW - cognitive style
KW - intellectual functioning
KW - 1967
KW - Cognitive Ability
KW - Cognitive Development
KW - Cognitive Style
KW - Nursery Schools
KW - Social Behavior
KW - 1967
DO - 10.1111/j.1939-0025.1967.tb00510.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40696-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40696-022
AN - 2013-40696-022
AU - Bower, Eli M.
T1 - American children and families in overseas communities.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/07//
VL - 37
IS - 4
SP - 787
EP - 796
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40696-022. PMID: 6033434 Partial author list: First Author & Affiliation: Bower, Eli M.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Cross Cultural Differences; Family; Mental Health. Minor Descriptor: Childhood Development. Classification: Community & Social Services (3373). Population: Human (10). Location: Europe. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1967.
AB - A significant number of American families, military and civilian, are based in Europe. Does living in a foreign culture have any positive or negative emotional impact on these families and their children? How adequate are the mental health and educational resources provided by the military? What new services might be needed for such communities? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American familiies
KW - children development
KW - communities
KW - cross cultural differences
KW - mental health
KW - 1967
KW - Community Services
KW - Cross Cultural Differences
KW - Family
KW - Mental Health
KW - Childhood Development
KW - 1967
DO - 10.1111/j.1939-0025.1967.tb00521.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40696-022&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Datta, Lois-Ellin
T1 - FAMILY RELIGIOUS BACKGROUND AND EARLY SCIENTIFIC CREATIVITY.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1967/08//
VL - 32
IS - 4
M3 - Article
SP - 626
EP - 635
SN - 00031224
AB - That achievement in the area of science varies systematically with religious background has been reported by some and cited by many. The inference is drawn that some values and attitudes associated with particular religious backgrounds are more conducive to scientific interest and achievement than are those associated with other religious backgrounds. The purpose of this study was to determine if the reported relationship between religion and 'creative' achievement found among adult male scientists was also found among adolescents who varied in potential scientific creativity as demonstrated by the projects they submitted to the Westinghouse Science Talent Search. In the adolescent sample, the potential scientific creativity ratings of projects submitted by students from Jewish families were higher than were the ratings of projects submitted by students from Catholic, 'liberal' Protestant, and 'fundamentalist' Protestant backgrounds. Interpretations of the religious background distributions that directly relate ascribed group values to the development of potential scientific creativity would be misleading, however, since the association was markedly reduced for Ss from larger cities and statistically reliable only for Ss from smaller hometowns and lower socioeconomic status. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CREATIVE ability in science
KW - RELIGION & science
KW - SCIENTISTS
KW - CALVINISTS
KW - SOCIALIZATION
KW - PROTESTANTS
KW - FAMILIES
KW - RELIGION
KW - ADOLESCENCE
KW - Scientific creativity
N1 - Accession Number: 12883880; Datta, Lois-Ellin 1; Affiliations: 1 : National Institutes of Health.; Source Info: Aug67, Vol. 32 Issue 4, p626; Historical Period: 1967; Subject Term: CREATIVE ability in science; Subject Term: RELIGION & science; Subject Term: SCIENTISTS; Subject Term: CALVINISTS; Subject Term: SOCIALIZATION; Subject Term: PROTESTANTS; Subject Term: FAMILIES; Subject Term: RELIGION; Subject Term: ADOLESCENCE; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=12883880&site=ehost-live&scope=site
DP - EBSCOhost
DB - ahl
ER -
TY - GEN
AU - Frome, Julius
T1 - An experimental practical approach to current awareness
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1967/08//
VL - 7
IS - 3
M3 - Article
SP - 135
EP - 137
SN - 00219576
AB - A practical experimental approach for a low cost current awareness system, which was fitted into an ongoing computer retrieval system, combines the functions of a science newspaper in the field as well as a current accessions bulletin. It can provide users with cards of abstracts of the articles upon request. The low cost is achieved by using mainly the computer input and output of the already existing retrievel system. The system is responsive to monthly changes in interest. It is expandable with little additional cost.
N1 - Accession Number: ISTA0300149; Frome, Julius 1; Affiliations: 1 : National Clearinghouse Of Mental Health Information, National Institute Of Mental Health, Md.; Source Info: August 1967, Vol. 7 Issue 3, p135; Note: Update Code: 0300; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Halperin, Max
AU - Rastogi, Suresh C.
AU - Ho, Irwin
AU - Yang, Y. Y.
T1 - SHORTER CONFIDENCE BANDS IN LINEAR REGRESSION.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1967/09//
VL - 62
IS - 319
M3 - Article
SP - 1050
SN - 01621459
AB - In many linear regression problems, the values of the independent variable or variables may be subject to certain constraints. For example, the independent variables may necessarily be positive; as another example, the variables may not only all be positive but are powers of a single variable (e.g., polynomial regression on time). Previous writers considering the problem of obtaining confidence bands on a regression function for all values of the independent variable have not utilized such constraints; the usual basis for such bands has been the multiple comparison procedure of Scheffe which places no constraints at all upon the independent variables. Any procedure utilizing constraints will necessarily yield a uniform improvement over the method of Scheffe (assuming both methods are applicable) in the sense of yielding narrower bands for a given confidence probability. In the present paper a nontrivial lower bound is obtained for the confidence probability associated with a multiple comparison procedure appropriate to the case where it can be assumed that each independent variable must be of specified sign; this includes, as a subclass, polynomial regression on a non-negative independent variable. This result gives a basis for a multiple comparison procedure less conservative than that of Scheffe when both are applicable. Implementation of the procedure requires the percentage points of a heretofore untabulated distribution. Tables of percentage points of this distribution appropriate to linear combinations of two, three, or four parameters are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - PROBABILITY theory
KW - CORRELATION (Statistics)
KW - ANALYSIS of variance
KW - VARIABLES (Mathematics)
N1 - Accession Number: 4605495; Halperin, Max 1; Rastogi, Suresh C. 2; Ho, Irwin 2; Yang, Y. Y. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; 2: Institute of International Medicine, University of Maryland.; Issue Info: Sep67, Vol. 62 Issue 319, p1050; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: ANALYSIS of variance; Subject Term: VARIABLES (Mathematics); Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2005-09870-005
AN - 2005-09870-005
AU - Lloyd, Dee Norman
T1 - Overinclusive thinking and delusions in schizophrenic patients: A critique.
JF - Journal of Abnormal Psychology
JO - Journal of Abnormal Psychology
JA - J Abnorm Psychol
Y1 - 1967/10//
VL - 72
IS - 5, Pt.1
SP - 451
EP - 453
CY - US
PB - American Psychological Association
SN - 0021-843X
SN - 1939-1846
N1 - Accession Number: 2005-09870-005. Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Lloyd, Dee Norman; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Style; Delusions; Schizophrenia; Thinking. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1967. Copyright Statement: American Psychological Association. 1967.
AB - Because of an error in the statistical paradigm, it is felt that conclusions of a study by R. W. Payne et al (see record [rid]1965-05763-001[/rid]) were not supported by their data. The average number of words to explain proverbs, a measure in that study, was calculated for 13 delusional, 13 suspected delusional, and 16 nondelusional schizophrenics. Significant difference among these groups was found, supporting the hypothesis that this measure is related to presence of delusions. Because of the purely quantitative nature of the measure and the possibility that it measures functions other than overinclusion, however, it was concluded that results using only this measure are not sufficient to support the proposed theoretical connection between overinclusion and the development of delusions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - overinclusive thinking
KW - delusions
KW - schizophrenic patients
KW - 1967
KW - Cognitive Style
KW - Delusions
KW - Schizophrenia
KW - Thinking
KW - 1967
DO - 10.1037/h0020110
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09870-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40698-016
AN - 2013-40698-016
AU - Dumont, Matthew P.
T1 - Tavern culture the sustenance of homeless men.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/10//
VL - 37
IS - 5
SP - 938
EP - 945
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40698-016. PMID: 6054549 Partial author list: First Author & Affiliation: Dumont, Matthew P.; Center for Studies of Metropolitan, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Welfare Services; Homeless. Minor Descriptor: Human Males; Personnel. Classification: Community & Social Services (3373). Population: Human (10); Male (30). References Available: Y. Page Count: 8. Issue Publication Date: Oct, 1967. Publication History: First Submitted Date: Aug 12, 1966.
AB - The needs of homeless men are not being met by health and welfare agencies. Observations of one community of such men reveals that a bartender and his tavern provide for many of these needs. Professionals can utilize the barroom as a point of intervention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homeless men
KW - welfare agencies
KW - communities
KW - professionals
KW - 1967
KW - Community Welfare Services
KW - Homeless
KW - Human Males
KW - Personnel
KW - 1967
DO - 10.1111/j.1939-0025.1967.tb00540.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40698-027
AN - 2013-40698-027
AU - Twain, David C.
T1 - Review of Street corner research.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1967/10//
VL - 37
IS - 5
SP - 987
EP - 988
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40698-027. Partial author list: First Author & Affiliation: Twain, David C.; Center for Studies of Crime and Delinquency, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Media. Language: English. Major Descriptor: Community Mental Health Training; Juvenile Delinquency; Operant Conditioning; Training. Minor Descriptor: Films; Mental Health; Personnel. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: Mason, Edward A. (Prod). Street corner research=30-minute, 16mm, black and white, sound film. Rental: Arranged. Purchase: $135. Center for Mass Communications, Columbia University Press, 440 West 110th St., New York, N.Y. 10025; 1967. Page Count: 2. Issue Publication Date: Oct, 1967.
AB - Reviews the film, Street Corner Research produced by Edward A. Mason (1967). The film 'Street Corner Research' vividly depicts the use of operant conditioning theory and techniques in contacting and eventually developing a meaningful relationship among delinquents, our 'research experts' above, and those persons interested in modifying delinquent behavior. The film shows us the contact, the soliciting of cooperation, and one interview session with a small group (two boys and a girl), at least one of whom is identified as 'delinquent.' This film is intended for the training of workers in the mental health field. This is an honest film, but perhaps too naive in oversimplifying the role of soft drinks and potato chips as reinforcers of desired behavior in a complex interpersonal situation. The film could have gone much further in documenting the background. It could have described more fully the aims and objectives, methods, personnel, and complex situations encompassed in the exciting and innovative community-based intervention program for delinquency control that is presented. The film does, however, clearly make the point that the hard-to-reach, hard to-counsel delinquent can be brought into a program with behavior-change potential. And it shows a technique which can be used by professional and nonprofessional alike as a working tool in delinquency control programs. and failures of 'street corner research.' It could have described more fully the aims and objectives, methods, personnel, and complex situations encompassed in the exciting and innovative community-based intervention program for delinquency control that is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - audio visuals
KW - films
KW - operant conditioning theory
KW - delinquent behavior
KW - workers training
KW - mental health
KW - community based intervention
KW - 1967
KW - Community Mental Health Training
KW - Juvenile Delinquency
KW - Operant Conditioning
KW - Training
KW - Films
KW - Mental Health
KW - Personnel
KW - 1967
U2 - Mason, Edward A. (Prod). (1967); Street corner research; 30-minute, 16mm, black and white, sound film. Rental: Arranged. Purchase: $135. Center for Mass Communications, Columbia University Press, 440 West 110th St., New York, N.Y. 10025
DO - 10.1037/h0097141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40698-027&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Asherson, G. L.
AU - Stone, S. H.
T1 - Desensitization in vitro-The Specific Inhibition, by Antigen, of the Passive Transfer of Delayed Hypersensitivity by Peritoneal Exudate Cells.
JO - Immunology
JF - Immunology
Y1 - 1967/11//
VL - 13
IS - 5
M3 - Article
SP - 469
EP - 475
SN - 00192805
AB - A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the 24-hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD. The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed hypersensitivity to PPD. Likewise, it was possible to diminish the passive transfer of delayed hypersensitivity to bovine γ-globulin by peritoneal exudate cells, by exposure of the ceils to bovine γ-globulin in vitro. The recipients were tested immediately after cell transfer. This in vitro desensitization was specific, in that the transfer of delayed hypersensitivity to PPD was unaffected. Exposure of cells in vitro to hypotonic conditions and antibody to guinea-pig γ-globulin did not prevent the passive transfer of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY desensitization
KW - ALLERGY
KW - GLOBULINS
KW - ANTIGENS
KW - ANIMAL models in research
KW - IMMUNOLOGY
N1 - Accession Number: 13342845; Asherson, G. L. 1; Stone, S. H. 2; Source Information: Nov67, Vol. 13 Issue 5, p469; Subject: ALLERGY desensitization; Subject: ALLERGY; Subject: GLOBULINS; Subject: ANTIGENS; Subject: ANIMAL models in research; Subject: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Bryan, S
AU - Epstein, M
T1 - Computer assisted primary index preparation
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1967/11//
VL - 7
IS - 4
M3 - Article
SP - 223
EP - 2321
SN - 00219576
AB - A man-machine primary indexing system employing a special 'indexing language' called bicept is fully described. The system is applicable for computer-processed or non-machine-readable text. It differs from most other machine indexing projects in that the specification of index items is largely manual. The method was applied to a journal article in an operational test.
N1 - Accession Number: ISTA0300927; Bryan, S 1; Epstein, M; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland 20014; Source Info: November 1967, Vol. 7 Issue 4, p223; Note: Update Code: 0300; Number of Pages: 2099p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Bartko, John J.
T1 - Variance Analysis of Complete Designs (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1967/12//
VL - 62
IS - 320
M3 - Book Review
SP - 1507
SN - 01621459
AB - Reviews the book "Variance Analysis of Complete Designs--Some Practical Aspects," by Paul Seeger.
KW - ANALYSIS of variance
KW - NONFICTION
KW - SEEGER, Paul
KW - VARIANCE Analysis of Complete Designs (Book)
N1 - Accession Number: 4607191; Bartko, John J. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Dec67, Vol. 62 Issue 320, p1507; Thesaurus Term: ANALYSIS of variance; Subject Term: NONFICTION; Reviews & Products: VARIANCE Analysis of Complete Designs (Book); People: SEEGER, Paul; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Bolster, Mel H.
T1 - The Strategic Deployment of Exceptional Talent: An Account of the Career Executive Roster's Short History.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1967/12//
VL - 27
IS - 5
M3 - Article
SP - 446
EP - 451
SN - 00333352
AB - Early in 1961 the US Civil Service Commission established the Career Executive Roster, then a new approach to the selection and utilization of top executives in the federal career service. . . . The program was superseded by the Career Executive Inventory, a part of the US Civil Service Commission's new Executive Assignment System.
KW - DEPLOYMENT (Military strategy)
KW - GOVERNMENT executives
KW - CAREER development
KW - UNITED States -- Officials & employees -- Selection & appointment
KW - CIVIL service
KW - PUBLIC administration
KW - EMPLOYEE selection
KW - GOVERNMENT agencies
KW - UNITED States
KW - Career Executive Roster
KW - Civil Service Commission
KW - UNITED States. Civil Service Commission
N1 - Accession Number: 4600879; Bolster, Mel H. 1; Affiliations: 1 : National Institutes of Health.; Source Info: Dec67, Vol. 27 Issue 5, p446; Historical Period: 1961 to 1966; Subject Term: DEPLOYMENT (Military strategy); Subject Term: GOVERNMENT executives; Subject Term: CAREER development; Subject Term: UNITED States -- Officials & employees -- Selection & appointment; Subject Term: CIVIL service; Subject Term: PUBLIC administration; Subject Term: EMPLOYEE selection; Subject Term: GOVERNMENT agencies; Subject: UNITED States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - Gen
ID - 9999-12926-000
AN - 9999-12926-000
AU - Waldrop, Mary F.
AU - Pedersen, Frank A.
AU - Bell, Richard Q.
T1 - Waldrop Anomaly Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1968///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-12926-000. Other Names: Waldrop Scale. Partial author list: First Author & Affiliation: Waldrop, Mary F.; National Institute of Mental Health, Betheda, Maryland, United States. Release Date: 20120910. Correction Date: 20160613. Instrument Type: Rating Scale. Test Format: For the 18 anomalies, scores of 0-2 are applied.. Language: English. Constructs: Minor Physical Anomalies; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300).
AB - Purpose: The purpose of the Waldrop Anomaly Scale is to assess the incidence of minor physical anomalies.
AB - Description: The Waldrop Anomaly Scale (Waldrop, Pederson, & Bell, 1968) was developed to assess the incidence of minor physical anomalies. The measure was constructed to enhance research relating physical anomalies and behavior in two samples of preschool children. These preschool children, who had been observed as newboms and had been considered free from complications of pregnancy and dehvery, were examined for the presence of 18 of the 21 minor physical anomalies used in the Goldfarb and Botstein (unpublished manuscript) investigation. Lack of permanent teeth, oversized incisors, and head circumference out of normal range were the 3 anomalies that the authors excluded from their list. Two examiners made independent judgments as to the existence and weight for each of the 18 minor physical defects on 10 of the 74 subjects and on 14 children from a nearby nursery school. A reliability coefficient of .70 was obtained from these two independent judgments as to the existence and weight of these 18 anomalies. The measure has also been used in a sample of schizophrenic males. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Physical Anomalies
KW - Test Development
KW - Waldrop Anomaly Scale
KW - Hyperkinetic Behavior
KW - Aggressive Behavior
KW - Preschool Students
KW - Schizophrenia
KW - Minor Physical Anomalies
U5 - Waldrop Anomaly Scale [Test Development]MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN. (AN: 1968-14315-001 from PsycINFO) WALDROP, MARY F.; PEDERSEN, FRANK A.; BELL, RICHARD Q.; 1968. Source: Child Development. 39(2), Blackwell Publishing, United Kingdom; 1968; Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Location: United States; Sample: 2 1/2-Year-Old Children Keywords: Physical Anomalies; Test Development; Waldrop Anomaly Scale; Hyperkinetic Behavior; Aggressive Behavior; Preschool Students; Subjects: Aggressive Behavior; Behavior Problems; Congenital Disorders; Hyperkinesis; Physical Appearance; Preschool Students; Rating Scales; Test Construction;
U5 - Waldrop Anomaly Scale [Test Use]The Incidence of Minor Physical Anomalies in Adult Male Schizophrenics. (AN: 2005-09727-009 from PsycINFO) Guy, James D.; Majorski, Lawrence V.; Wallace, Charles J.; Guy, Margaret P.; 1983. Source: Schizophrenia Bulletin. 9(4), National Institute of Mental Health, US; 1983; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Inpatient; Outpatient; Sample: Male Schizophrenic Inpatients at Camarillo State Hospital and Day Treatment Patients at Harbor-UCLA Medical Center Keywords: Schizophrenia; Waldrop Anomaly Scale; Minor Physical Anomalies; Subjects: Congenital Disorders; Genetic Linkage; Physical Disfigurement; Schizophrenia;
DO - 10.1037/t12926-000
L3 - Full; Full text; 999912926_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - GEN
AU - Sloan, Margaret H
T1 - The relationships of medical libraries to regional medical program planning
JO - Bulletin of the Medical Library Association
JF - Bulletin of the Medical Library Association
Y1 - 1968/01//
VL - 56
IS - 1
M3 - Article
SP - 56
EP - 58
SN - 00257338
AB - Regional medical program grants will soon cover 98% of the u.s. Population and grantees are encouraged to apply for library assistance in planning for regional medical service. The community hospital learning center is an important concept in this service. Wherever a doctor takes his patients for hospitalization he should have access, through dataphone or other means, to the learning materials he needs. A hospital learning carrel would contain records, video tapes, and programmed learning materials in addition to the most used journals and textbooks. The library profession must consider what help is needed from the regional medical program in order to meet the staff and training demands that go with provision of such service.
N1 - Accession Number: ISTA0401307; Sloan, Margaret H 1; Affiliations: 1 : Regional Medical Programs, National Institutes Of Health, Bethesda, Maryland.; Source Info: January 1968, Vol. 56 Issue 1, p56; Note: Update Code: 0400; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Drews, J.
AU - Brawerman, G.
AU - Morris, H. P.
T1 - Nucleotide Sequence Homologies in Nuclear and Cytoplasmic Ribonucleic Acid from Rat Liver and Hepatomas.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/01//
VL - 3
IS - 3
M3 - Article
SP - 284
EP - 292
SN - 00142956
AB - The RNA populations of rat liver and three rat hepatomas were compared by DNA-RNA hybridization studies in the presence and absence of competing RNA. The hepatoma nuclei were found to lack hybridizable RNA species present in normal liver nuclei, while the latter appeared to contain all the hepatoma RNA species. In normal liver, the cytoplasmic RNA could compete with nuclear RNA only to the extent of 20–30%. This indicates that a large number of nuclear RNA species are not transferred to the cytoplasm. In the case of the hepatomas nearly all the nuclear RNA species were detected in the cytoplasmic RNA preparations. A more extensive homology between nuclear and cytoplasmic RNA was also observed in regenerating liver. It is suggested that a selective mechanism governs the transfer of RNA species from the nucleus to the cytoplasm and that this mechanism is altered in the hepatomas. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMOLOGY (Biology)
KW - NUCLEOTIDE sequence
KW - RNA
KW - LIVER tumors
KW - HEPATOMA
KW - RATS as laboratory animals
N1 - Accession Number: 12768108; Drews, J. 1,2; Brawerman, G. 2,3; Morris, H. P. 2,4; Source Information: 1968, Vol. 3 Issue 3, p284; Subject: HOMOLOGY (Biology); Subject: NUCLEOTIDE sequence; Subject: RNA; Subject: LIVER tumors; Subject: HEPATOMA; Subject: RATS as laboratory animals; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Schneider, John H
T1 - Experimental trial of selective dissemination of biomedical information in an automated system based on a linear hierarchical decimal classification
JO - In American Society For Information Science, Proceedings, 5. Annual Meeting, October 20-24, 1968. Columbus, Ohio. P. 243-245. 1 Illus. 5 Ref. See Isa 69-010/y
JF - In American Society For Information Science, Proceedings, 5. Annual Meeting, October 20-24, 1968. Columbus, Ohio. P. 243-245. 1 Illus. 5 Ref. See Isa 69-010/y
Y1 - 1968///
M3 - Book Chapter
AB - The need is discussed for small-scale experimental-information systems, which provide data on the cost of the system and on the quality of selectivity of the match between user and document. As an example, a one-year trial of a linear, hierarchical, decimal classification of biomedical information for matching any one number assigned to an article against any one number assigned to a user profile is described. The operation of the system, the nature of the one-year trial, the method of evaluation, and some final results are presented.
N1 - Accession Number: ISTA0400326; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland; Source Info: 1968; Note: Update Code: 0400; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Schneider, John H
T1 - A computerized system based on a hierarchical decimal classification: use for selective dissemination of biomedical information (sdi)
JO - In Ramey, James W., Ed. Fifth Annual National Colloquium On Information Retrieval; Impact Of Mechanization On Libraries And Information. Centers. 1968. Information Interscience Incorporated, Philadelphia. P. 137-143. 4 Illus. 3 Ref
JF - In Ramey, James W., Ed. Fifth Annual National Colloquium On Information Retrieval; Impact Of Mechanization On Libraries And Information. Centers. 1968. Information Interscience Incorporated, Philadelphia. P. 137-143. 4 Illus. 3 Ref
Y1 - 1968///
M3 - Book Chapter
AB - The use of a hierarchical decimal classification in a computerized information system is described in this paper. The initial trial is designed to test how well the system can match the information needs of scientists against the information content of published journal articles. In addition, time and effort data are collected so that the cost and performance of large-scale operations can be accurately predicted. The system is designed to operate on a realistic and economically sound basis in order to relate the results directly to real-life situations. For this reason, theoretical, artificial testing and evaluation protocols have been avoided. Instead, 103 cancer research scientists are sent summaries of published articles appearing in cancer research journals. Users rate their interest in each article, whether the article is of use, and how closely it is related to current research. Computer cost for matching document with user is less than 0.1 cent per article matched against the profile of one scientist. We have close to an 85% return of the first 3,700 evaluation slips. Of the first 2.679 replies, 24% found the summary 'very useful.' another 28% were of 'definite but limited use,' and 30% were at least 'of little or slight use.' only 18% of the summaries mailed were rated as of 'no significant use.' these figures include all the initial replies before any profile revision.
N1 - Accession Number: ISTA0600809; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland; Source Info: 1968; Note: Update Code: 0600; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Martin, Jess A
T1 - Planning the new nih research library
JO - Special Libraries
JF - Special Libraries
Y1 - 1968/01//
VL - 59
IS - 1
M3 - Article
SP - 30
EP - 38
SN - 00386723
AB - Emphasizes the steps in planning, building, and moving into a new special library facility, including the contributions of architects, engineers, administrators, library committee members, users, professional consultants, and the library staff. Each contribution will be included in such basic documents as a program of requirements and equipment specifications. A day-by-day schedule of the projected move is appended together with a selected bibliography of new library buildings 1690-67.
N1 - Accession Number: ISTA0300476; Martin, Jess A 1; Affiliations: 1 : National Institutes Of Health, U.s. Department Of Health, Education And Welfare; Source Info: January 1968, Vol. 59 Issue 1, p30; Note: Update Code: 0300; Number of Pages: 9p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0300476&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2013-40697-002
AN - 2013-40697-002
AU - Rae-Grant, Quentin A. F.
AU - Marcuse, Donald J.
T1 - The hazards of teamwork.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1968/01//
VL - 38
IS - 1
SP - 4
EP - 8
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40697-002. PMID: 5637332 Partial author list: First Author & Affiliation: Rae-Grant, Quentin A. F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Column/Opinion. Language: English. Major Descriptor: Hazards; Mental Health; Organizations; Work Teams. Minor Descriptor: Membership; Professional Development. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Page Count: 5. Issue Publication Date: Jan, 1968.
AB - The opinion article presents the hazards of teamwork. Teams, like institutions, may provide a protective mantle for their members to hide under, reducing the likelihood of direct interaction or communication with patients, who become increasingly isolated in the Kafkaesque process. The ultimate argument offered to defend the conjoint acting out of a dichotomy between the firm directive and the gentle understanding attitude is that no one person could embody both, if the situation required it. The article also illustrates a more general hazard of teamwork a hazard of team spirit. Team spirit connotes a will to win. It thrives in a context of rivalry and when a common enemy is perceived. The resulting downgrading of independent work would hurt any profession or any team or organization, but the loss in the mental health field would be uniquely crippling because of the very special and irreplaceable contribution such work offers in clinical pursuits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - team work
KW - hazards
KW - team members
KW - organizations
KW - professional development
KW - mental health
KW - 1968
KW - Hazards
KW - Mental Health
KW - Organizations
KW - Work Teams
KW - Membership
KW - Professional Development
KW - 1968
DO - 10.1111/j.1939-0025.1968.tb00548.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-09110-001
AN - 1968-09110-001
AU - Crane, George E.
T1 - Tardive dyskinesia in patients treated with major neuroleptics: A review of the literature.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1968///
VL - 124
IS - 8, SUPPL.
SP - 40
EP - 48
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1968-09110-001. Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Crane, George E.; National Institute of Mental Health, Chevy Chase, MD, US. Release Date: 19680101. Correction Date: 20161208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Drugs; Literature Review; Nervous System Disorders; Psychiatric Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Methodology: Literature Review. Page Count: 9. Issue Publication Date: 1968.
AB - SINCE 1959 A GROWING NUMBER OF REPORTS HAVE DESCRIBED A NEW TYPE OF NEUROLOGICAL DISORDER IN MENTAL PATIENTS. THIS DISORDER, KNOWN AS TARDIVE DYSKINESIA, HAS BEEN OBSERVED IN APPROXIMATELY 500 CASES BUT, JUDGING FROM THE ACCURATE OBSERVATIONS MADE BY 3 SEPARATE GROUPS OF INVESTIGATORS, THE SYNDROME IS LIKELY TO BE MORE FREQUENT THAN MAY BE SUSPECTED. ALTHOUGH MANIFESTATIONS OF TARDIVE DYSKINESIA OCCUR IN A NUMBER OF DISEASES OF THE CNS, THERE IS CONSIDERABLE EVIDENCE THAT THE LARGE-SCALE USE OF PHENOTHIAZINES OR SIMILAR DRUGS IN RECENT YR. IS RESPONSIBLE FOR THE GREAT NUMBER OF PATIENTS IN MENTAL HOSPITALS EXHIBITING MYOCLONIA AND CHOREO-ATHETOID SYMPTOMS. (58 REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - TARDIVE DYSKINESIA & NEUROLEPTIC TREATMENT
KW - REVIEW OF LITERATURE
KW - 1968
KW - Drug Therapy
KW - Drugs
KW - Literature Review
KW - Nervous System Disorders
KW - Psychiatric Patients
KW - 1968
DO - 10.1176/ajp.124.8S.40
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-09110-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40697-026
AN - 2013-40697-026
AU - Rae-Grant, Quentin
T1 - Review of Community and schizophrenia.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1968/01//
VL - 38
IS - 1
SP - 170
EP - 172
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40697-026. Partial author list: First Author & Affiliation: Rae-Grant, Quentin; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Community Services; Schizophrenia; Social Class; Social Processes. Minor Descriptor: Antisocial Behavior. Classification: Schizophrenia & Psychotic States (3213); Community & Social Services (3373). Population: Human (10). Reviewed Item: Dunham, H. Warren. Community and schizophrenia=Detroit: Wayne State University Press. 312 pp. $12.50; 1965. Page Count: 3. Issue Publication Date: Jan, 1968.
AB - Reviews the book, Community and Schizophrenia by H. Warren Dunham (see record [rid]1966-01810-000[/rid]). The book presents a comprehensive survey of methodological difficulties and a critical review of previous work and conclusions. The book provides comprehensive, detailed, and analytic review of the whole problem of epidemiology in mental health. The one part of the book examines various hypotheses regarding the relationship between community organization and social class, on the one hand, and the disease known as schizophrenia on the other. The present work raises considerable doubt that there is any causal relationship between either the type of community or social class and the incidence of schizophrenia. The book summarizes the distribution of schizophrenics in community is dependent on the process of social selection. The book is a very clear, valuable and represents the distillation of 30 years work, knowledge of the problems, and refinement of instruments and methodology, for an epidemiologists. For all serious students of deviant behavior, its individual and community origins and therefore of methods of informed intervention, it is obviously one that will become both valuable and required reading. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community services
KW - schizophrenia
KW - social class
KW - deviant behavior
KW - social processes
KW - 1968
KW - Community Services
KW - Schizophrenia
KW - Social Class
KW - Social Processes
KW - Antisocial Behavior
KW - 1968
U2 - Dunham, H. Warren. (1965); Community and schizophrenia; Detroit: Wayne State University Press. 312 pp. $12.50
DO - 10.1037/h0097557
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40697-033
AN - 2013-40697-033
AU - Wiener, Jack
T1 - Mental health highlights.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1968/01//
VL - 38
IS - 1
SP - 182
EP - 186
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40697-033. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Medical Sciences; Rehabilitation; Social Services. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 5. Issue Publication Date: Jan, 1968.
AB - This article presents mental health highlights, which focuses on rehabilitation services, medical services, social services, community mental health services, stress and many other topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health services
KW - medical services
KW - mental health highlights
KW - rehabilitation services
KW - social services
KW - 1968
KW - Community Mental Health Services
KW - Medical Sciences
KW - Rehabilitation
KW - Social Services
KW - 1968
DO - 10.1111/j.1939-0025.1968.tb00570.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40697-033&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-13315-001
AN - 1968-13315-001
AU - Essig, C. F.
T1 - Increased water consumption following forced drinking of alcohol in rats.
JF - Psychopharmacologia
JO - Psychopharmacologia
Y1 - 1968///
VL - 12
IS - 4
SP - 333
EP - 337
CY - Germany
PB - Springer
N1 - Accession Number: 1968-13315-001. PMID: 5690025 Partial author list: First Author & Affiliation: Essig, C. F.; National Institute of Mental Health, Addiction Research Center, Lexington, KY, US. Release Date: 19680101. Correction Date: 20161208. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biochemistry; Drugs; Water Deprivation; Water Intake; Water Transportation. Minor Descriptor: Alcohol Drinking Patterns; Rats; Water Safety. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 5. Issue Publication Date: 1968.
AB - AN ATTEMPT WAS MADE TO INDUCE PHYSICAL DEPENDENCE IN RATS BY RESTRICTING THEIR FLUID INTAKE TO CONCENTRATIONS OF ALCOHOL THAT WERE INCREASED FROM 5-20%. ALCOHOL INTAKE DECREASED DURING THE MONTH THAT THE 20% CONCENTRATION WAS AVAILABLE. FOLLOWING ALCOHOL WITHDRAWAL, WATER WAS CONSUMED IN SIGNIFICANTLY GREATER AMOUNTS THAN IN CONTROL RATS. A FLUID DEFICIT MIGHT HAVE DEVELOPED SO THAT AN INCREASE IN WATER CONSUMPTION OCCURRED WHEN IT BECAME AVAILABLE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ALCOHOL/FORCED INGESTION OF
KW - SUBSEQUENT INCREASE IN WATER INTAKE
KW - RAT
KW - 1968
KW - Biochemistry
KW - Drugs
KW - Water Deprivation
KW - Water Intake
KW - Water Transportation
KW - Alcohol Drinking Patterns
KW - Rats
KW - Water Safety
KW - 1968
DO - 10.1007/BF00401411
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-13315-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-13462-001
AN - 1968-13462-001
AU - Moss, Howard A.
AU - Robson, Kenneth S.
T1 - Maternal influences in early social visual behavior.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1968///
VL - 39
IS - 2
SP - 401
EP - 408
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
N1 - Accession Number: 1968-13462-001. PMID: 5652768 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Moss, Howard A.; National Institute of Mental Health. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19680101. Correction Date: 20161229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Maternal Behavior; Mother Child Relations; Social Interaction; Vision. Classification: Developmental Psychology (2800). Population: Animal (20). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Page Count: 8. Issue Publication Date: 1968.
AB - POSITIVE ATTITUDES TOWARD INFANTS WERE ASSESSED IN 54 PRIMIPAROUS MOTHERS DURING PREGNANCY. IN SUBSEQUENT HOME OBSERVATIONS, THE FREQUENCY AT 1 AND 3 MO. OF AGE WITH WHICH MOTHER AND INFANT SIMULTANEOUSLY LOOKED AT ONE ANOTHER'S FACES (VIS-A-VIS) WAS RECORDED. AT 31/4 MO. MOST OF THESE INFANTS WERE SHOWN A SERIES OF GEOMETRIC AND SOCIAL STIMULI TO WHICH TOTAL FIXATION TIMES WERE CALCULATED. FOR FEMALE INFANTS THE PREGNANCY RATINGS, VIS-A-VIS SCORES, AND TOTAL FIXATION TIMES TO SOCIAL STIMULI WERE ALL POSITIVELY INTERCORRELATED. HOWEVER, FOR MALES THE PREGNANCY RATINGS WERE SIGNIFICANTLY ASSOCIATED ONLY WITH THE 1-MO SCORE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SOCIAL VISUAL BEHAVIOR & MATERNAL INFLUENCE
KW - SEX DIFFERENCES
KW - 1-3 MO. OLD INFANTS
KW - 1968
KW - Animal Maternal Behavior
KW - Mother Child Relations
KW - Social Interaction
KW - Vision
KW - 1968
DO - 10.2307/1126954
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-13462-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-08510-001
AN - 1968-08510-001
AU - Meltzer, Herbert
T1 - Creatine kinase and aldolase in serum: Abnormality common to acute psychoses.
JF - Science
JO - Science
JA - Science
Y1 - 1968///
VL - 159
IS - 3821
SP - 1368
EP - 1370
CY - US
PB - American Assn for the Advancement of Science
SN - 0036-8075
N1 - Accession Number: 1968-08510-001. PMID: 5644267 Partial author list: First Author & Affiliation: Meltzer, Herbert; National Institutes of Health, Bethesda, MD, US. Release Date: 19680101. Correction Date: 20161205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biochemistry; Drugs; Psychosis. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Page Count: 3. Issue Publication Date: 1968.
AB - ACTIVITY OF CREATINE KINASE AND ALDOLASE IN SERUM INCREASED IN 14 OF 16 PATIENTS WITH RECENT ONSET OF A PSYCHOTIC REACTION, AND IN 5 OF 6 PATIENTS TREATED WITH PSYCHOTOMIMETIC DRUGS. THERE WAS EITHER NO INCREASE OF THESE ENZYMES OR A SLIGHT INCREASE IN SEVERELY AGITATED (OR DEPRESSED) NONPSYCHOTIC HOSPITALIZED PATIENTS AND CHRONIC PSYCHOTIC PATIENTS. THE INCREASE OF THE ENZYMES PRECEDED THE ONSET OF THE ACUTE PSYCHOTIC SYMPTOMS IN AT LEAST 3 CASES, WAS HIGHEST DURING THE 1ST 2 WK. OF A PSYCHOTIC EPISODE, AND SOMETIMES RECURRED THROUGHOUT THE ILLNESS, PARTICULARLY AT TIMES OF STRESS. THE CREATINE KINASE IN THE SERUM IS PRIMARILY OF THE MUSCLE TYPE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - CREATINE KINASE & ALDOLASE
KW - PSYCHOTOMIMETIC DRUGS
KW - PSYCHOTICS
KW - 1968
KW - Biochemistry
KW - Drugs
KW - Psychosis
KW - 1968
DO - 10.1126/science.159.3821.1368
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-08510-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ward, Charles D.
AU - Barrett, James E.
T1 - THE ECUMENICAL COUNCIL AND ATTITUDE CHANGE AMONG CATHOLIC, PROTESTANT, AND JEWISH COLLEGE STUDENTS.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1968/02//
VL - 74
IS - 1
M3 - Article
SP - 91
EP - 96
SN - 00224545
AB - A total of 219 subjects of differing religions were given attitude questionnaires at the beginning and conclusion of the fourth meeting of the Vatican Ecumenical Council. A supplementary sample of 107 subjects completed the same questionnaire some five months after the Council had adjourned. It was found that Catholics became more favorable toward birth control, and more so than did Protestants or Jews. At the beginning of the Council's meeting Catholics were slightly more anti-Semitic than Protestants, but five months after the Council's adjournment the Catholics were lower in anti-Semitism than were the Protestants, although not significantly so. No sizeable differences in attitudes were found on the Negro and religious intermarriage issues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Social Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATTITUDE change (Psychology)
KW - COLLEGE students
KW - CATHOLICS
KW - ATTITUDE (Psychology)
KW - PROTESTANTS
KW - QUESTIONNAIRES
KW - DECISION MAKING AND COMMUNICATIONS
KW - Patterns of opinion spread and opinion change
KW - Racial and ethnic aspects of tension
N1 - Accession Number: 16489225; Ward, Charles D. 1; Barrett, James E. 2; Affiliations: 1 : Department of Psychology, University of Maryland.; 2 : National Institutes of Health.; Source Info: Feb1968, Vol. 74 Issue 1, p91; Subject Term: ATTITUDE change (Psychology); Subject Term: COLLEGE students; Subject Term: CATHOLICS; Subject Term: ATTITUDE (Psychology); Subject Term: PROTESTANTS; Subject Term: QUESTIONNAIRES; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Author-Supplied Keyword: Racial and ethnic aspects of tension; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=24h&AN=16489225&site=ehost-live&scope=site
DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
ID - 2005-09872-001
AN - 2005-09872-001
AU - Katz, Martin M.
AU - Waskow, Irene E.
AU - Olsson, James
T1 - Characterizing the psychological state produced by LSD.
JF - Journal of Abnormal Psychology
JO - Journal of Abnormal Psychology
JA - J Abnorm Psychol
Y1 - 1968/02//
VL - 73
IS - 1
SP - 1
EP - 14
CY - US
PB - American Psychological Association
SN - 0021-843X
SN - 1939-1846
N1 - Accession Number: 2005-09872-001. PMID: 5639999 Other Journal Title: The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Katz, Martin M.; Psychopharmacology Research Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Meetings of the Collegium Internationale Neuropsychopharmacologicum, Mar, 1966, Washington, DC, US. Conference Note: Based on a paper presented at the aforementioned meetings. Major Descriptor: Amphetamine; Emotions; Lysergic Acid Diethylamide; Psychopharmacology. Minor Descriptor: Male Criminals; Prisoners; Verbal Communication; Vocalization. Classification: Psychopharmacology (2580). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Subjective Drug Effects Questionnaire; Picture Rating Technique. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Feb, 1968. Copyright Statement: American Psychological Association. 1968.
AB - Two studies, involving 69 male inmates of an experimental penal institution, investigated the psychological states produced by LSD as compared with amphetamine and placebo controls. A number of scales on a newly developed subjective drug-effects questionnaire significantly differentiated the groups. This instrument was further used to identify 3 qualitatively different subjective states produced by LSD (moderately euphoric, dysphoric, and ambivalent). New techniques for exploring the perceptual and vocal components of emotional change were also applied. These techniques further elucidated the quality and possible origin of the psychological states produced by LSD. The results (which indicate the presence of highly intense but contradictory emotions) were interpreted in the light of a current theory of emotion and Bartlett's concept of 'effort after meaning.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological states
KW - LSD
KW - amphetamines
KW - drug effects
KW - verbal behavior
KW - vocal behavior
KW - emotions
KW - male inmates
KW - 1968
KW - Amphetamine
KW - Emotions
KW - Lysergic Acid Diethylamide
KW - Psychopharmacology
KW - Male Criminals
KW - Prisoners
KW - Verbal Communication
KW - Vocalization
KW - 1968
DO - 10.1037/h0020114
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09872-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-08747-001
AN - 1968-08747-001
AU - Bell, Richard Q.
T1 - A reinterpretation of the direction of effects in studies of socialization.
JF - Psychological Review
JO - Psychological Review
JA - Psychol Rev
Y1 - 1968/03//
VL - 75
IS - 2
SP - 81
EP - 95
CY - US
PB - American Psychological Association
SN - 0033-295X
SN - 1939-1471
N1 - Accession Number: 1968-08747-001. PMID: 4870552 Partial author list: First Author & Affiliation: Bell, Richard Q.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 19680101. Correction Date: 20161205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Parent Child Relations; Socialization. Classification: Developmental Psychology (2800); Social Psychology (3000). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 15. Issue Publication Date: Mar, 1968. Copyright Statement: American Psychological Association. 1968.
AB - STUDIES ARE SUMMARIZED INDICATING THAT THE BASIC MODEL OF SOCIALIZATION, THE ACTION OF A PARENT ON A CHILD, IS TOO LIMITED TO ACCOMMODATE DATA EMERGING FROM RECENT STUDIES OF HUMAN AND ANIMAL SS. A SET OF PROPOSITIONS IS PRESENTED CONCERNING THE EFFECTS OF CONGENITAL FACTORS IN CHILDREN ON PARENT BEHAVIOR. THIS SYSTEM IS APPLIED TO CURRENT FINDINGS IN SEVERAL MAJOR AREAS. CURRENT LITERATURE ON SOCIALIZATION, BASED LARGELY ON CORRELATIONS BETWEEN PARENT AND CHILD BEHAVIOR, CAN BE REINTERPRETED PLAUSIBLY AS INDICATING EFFECTS OF CHILDREN ON PARENTS. A CORRELATION DOES NOT INDICATE DIRECTION OF EFFECT. IT IS FELT THAT THE EFFECT OF CHILDREN ON PARENTS CAN NO LONGER BE DISMISSED AS ONLY A LOGICAL BUT IMPLAUSIBLE ALTERNATIVE EXPLANATION OF A CORRELATION. (2 P. REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - CHILDREN ON PARENTS/EFFECT OF
KW - 1968
KW - Parent Child Relations
KW - Socialization
KW - 1968
DO - 10.1037/h0025583
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-08747-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Purdy, Marie E
AU - Schless, Arthur P
AU - Stevenson, Robert E
T1 - Reading guide and index to the cancervirology literature
JO - American Documentation
JF - American Documentation
Y1 - 1968/04//
VL - 19
IS - 2
M3 - Article
SP - 163
EP - 167
SN - 0096946X
AB - An alerting service to the pertinent articles in the field of cancer-virology has been in operation, successfully, for four years. By cooperative efforts, approximately 200 investigators are kept aware of useful information in 230 journals. Its low cost, ease of operation and extensive up-to-date coverage make it an attractive model for many other applications. An information retrieval addition to this system is discussed.
N1 - Accession Number: ISTA0301266; Purdy, Marie E 1; Schless, Arthur P; Stevenson, Robert E; Affiliations: 1 : National Cancer Institute.; Source Info: April 1968, Vol. 19 Issue 2, p163; Note: Update Code: 0300; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0301266&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Schless, Arthur P.
AU - Purdy, Marie E.
AU - Stevenson, Robert E.
T1 - Reading Guide and Index to the Cancer-Virology Literature.
JO - American Documentation
JF - American Documentation
Y1 - 1968/04//
VL - 19
IS - 2
M3 - Article
SP - 163
EP - 167
SN - 0096946X
AB - An alerting service to the pertinent articles in the field of cancer-virology has been in operation, successfully, for four years. By cooperative efforts, approximately 200 investigators are kept aware of useful information in 230 journals. Its low cost, ease of operation, and extensive up-to-date coverage make it an attractive model for many other applications. An information retrieval addition to this system is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Documentation is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFORMATION retrieval
KW - INFORMATION storage & retrieval systems
KW - INFORMATION resources management
KW - CANCER
KW - VIROLOGY
KW - PERIODICALS
N1 - Accession Number: 16864590; Schless, Arthur P. 1; Purdy, Marie E. 1; Stevenson, Robert E. 1; Affiliations: 1: Viral Carcinogenesis Branch National Cancer Institute Bethesda, Maryland.; Issue Info: Apr1968, Vol. 19 Issue 2, p163; Thesaurus Term: INFORMATION retrieval; Thesaurus Term: INFORMATION storage & retrieval systems; Thesaurus Term: INFORMATION resources management; Subject Term: CANCER; Subject Term: VIROLOGY; Subject Term: PERIODICALS; NAICS/Industry Codes: 519190 All Other Information Services; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2013-40690-026
AN - 2013-40690-026
AU - Yarrow, Leon J.
AU - Pedersen, Frank A.
T1 - Review of Determinants of infant behavior, III.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1968/04//
VL - 38
IS - 3
SP - 571
EP - 573
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40690-026. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Animal Maternal Behavior; Infant Development; Mother Child Relations. Minor Descriptor: Home Environment; Kibbutz; Rats. Classification: Social & Instinctive Behavior (2440). Population: Human (10); Animal (20); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Reviewed Item: Foss, B. M. (Ed). Determinants of infant behavior, III=New York: John Wiley & Sons, 264 pp; 1965. Page Count: 3. Issue Publication Date: Apr, 1968.
AB - Reviews the book, Determinants of Infant Behavior, III edited by B. M. Foss (see record [rid]1966-07541-000[/rid]). This report of the third seminar on Mother-Infant Interaction reflects a major shift during the past decade towards direct observation of mothers and infants in natural settings, and toward differentiated analyses of mother-infant interactions. The papers reflect this diversity around a common theme by the varied points of view. A study of how the characteristics of the offspring affect the maternal behavior cycle in rats points to the infant's role in maintaining basic maternal behavior patterns. Another study of diverse childrearing environments in Israel, made detailed observations throughout the entire day of children and caretakers. Some papers suggests that there may be an overemphasis on constitutional differences as determinants of the infant's earliest interactions with the mother. A study of twins in early infancy found evidence suggesting a genetic basis for the development of positive social orientation and fear of strangers. Other interesting reports included in this volume focus on Kibbutz and family environment; a classification scheme for systematic analysis of interaction patterns. The book reflects the current state of this research area: many important issues are illuminated, but few are resolved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant behavior
KW - mother infant interaction
KW - rats
KW - maternal behavior
KW - Kibbutz
KW - family environment
KW - 1968
KW - Animal Maternal Behavior
KW - Infant Development
KW - Mother Child Relations
KW - Home Environment
KW - Kibbutz
KW - Rats
KW - 1968
U2 - Foss, B. M. (Ed). (1965); Determinants of infant behavior, III; New York: John Wiley & Sons, 264 pp
DO - 10.1037/h0097148
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40690-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Draper, L.R.
AU - Hirata, A.A.
T1 - Antibody Responses in Rabbits to Soluble and Particulate Forms of Bovine Serum Albumin.
JO - Immunology
JF - Immunology
Y1 - 1968/07//
VL - 15
IS - 1
M3 - Article
SP - 23
EP - 30
SN - 00192805
AB - Antibody responses to an insoluble derivative of bovine serum albumin (IBSA) and to its corresponding soluble form (SBSA) were compared in rabbits. The two antigens could not be distinguished serologically. Less IBSA than SBSA was required to induce a detectable primary response. At higher doses, 10-20 mg/kg, IBSA evoked more prompt primary and secondary responses than SBSA but peak litres were sometimes higher in the SBSA group. After secondary injections, serum antibody litre persisted for at least 18 months in most rabbits. Early in the primary response to either form of antigen a substantial proportion of the serum antibody was of the 19S type. The shift to 7S production occurred abruptly and early after IBSA injection but it was gradual after SBSA injection, which suggested a relatively prolonged period of induction in the latter case. 75 antibody predominated during the secondary response to both antigens although the proportion of 1 9S antibody increased somewhat 4 weeks after the reinjection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - GLOBULINS
KW - ANTIGENS
KW - PLASMA cells
KW - IMMUNITY
KW - IMMUNOLOGY
N1 - Accession Number: 13346171; Draper, L.R. 1; Hirata, A.A. 1; Source Information: Jul68, Vol. 15 Issue 1, p23; Subject: IMMUNOGLOBULINS; Subject: GLOBULINS; Subject: ANTIGENS; Subject: PLASMA cells; Subject: IMMUNITY; Subject: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2005-10454-003
AN - 2005-10454-003
AU - Shakow, David
T1 - Apology.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1968/07//
VL - 23
IS - 7
SP - 535
EP - 535
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2005-10454-003. Partial author list: First Author & Affiliation: Shakow, David; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20060327. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Erratum/Correction. Language: English. Major Descriptor: Frustration; Government; Null Hypothesis Testing; Occupations; Personnel. Minor Descriptor: Apology. Classification: Industrial & Organizational Psychology (3600). Page Count: 1. Issue Publication Date: Jul, 1968. Copyright Statement: American Psychological Association. 1968.
AB - Reports an error in the original article by D. Shakow (American Psychologist, 1968, 23, pp. 87-96). I am mortified to have overdone the l's in my article, 'On the Rewards (and, Alas, Frustrations) of Public Service'. It was not General Stillwell who was responsible for illegitimati non carborundum, but General Stilwell. Fortunately, one of the proper Stilwells of psychology was around to bring me into line. I apologize to all the 'single-elled' Stilwells. (The following abstract of this article originally appeared in record [rid]1968-09533-001[/rid].) Urges that government support also extend to creative work and individuality as government operations expand. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment
KW - rewards
KW - frustrations
KW - 1968
KW - Frustration
KW - Government
KW - Null Hypothesis Testing
KW - Occupations
KW - Personnel
KW - Apology
KW - 1968
DO - 10.1037/h0020805
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10454-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40689-017
AN - 2013-40689-017
AU - Kramer, Martin A.
T1 - Responsible systems of care for community mental health centers.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1968/07//
VL - 38
IS - 4
SP - 700
EP - 704
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40689-017. PMID: 5661554 Partial author list: First Author & Affiliation: Kramer, Martin A.; Mental Health Facilities Branch, Division of Mental Health Service Programs, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1967, Washington, DC, US. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Community Mental Health; Community Mental Health Centers; Mental Health Services. Minor Descriptor: Goals. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 5. Issue Publication Date: Jul, 1968.
AB - Current conceptual models for the delivery of mental health services lead us to lose sight of certain aspects of our ultimate goal while emphasizing others. As with all conceptual models, they tend to pass unquestioned. This paper reexamines the unstated premises of three such models. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health
KW - conceptual models
KW - mental health centers
KW - mental health services
KW - ultimate goals
KW - 1968
KW - Community Mental Health
KW - Community Mental Health Centers
KW - Mental Health Services
KW - Goals
KW - 1968
DO - 10.1111/j.1939-0025.1968.tb02440.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Bowen, W. J.
AU - Evans Jr., T. C.
T1 - The Binding of ATP to Myosins B and A.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/09//
VL - 5
IS - 4
M3 - Article
SP - 507
EP - 512
SN - 00142956
AB - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphatecreatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphate
KW - MYOSIN
KW - NUCLEOTIDES
KW - PROTEINS
KW - BIOCHEMISTRY
KW - CREATINE
N1 - Accession Number: 12791312; Bowen, W. J. 1,2; Evans Jr., T. C. 1,3; Source Information: 1968, Vol. 5 Issue 4, p507; Subject: ADENOSINE triphosphate; Subject: MYOSIN; Subject: NUCLEOTIDES; Subject: PROTEINS; Subject: BIOCHEMISTRY; Subject: CREATINE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Colten, H. R.
AU - Silverstein, A. M.
AU - Bonos, T.
AU - Rapp, H. J.
T1 - Ontogeny of the First Component of Sheep Complement.
JO - Immunology
JF - Immunology
Y1 - 1968/09//
VL - 15
IS - 3
M3 - Article
SP - 459
EP - 461
SN - 00192805
AB - Discusses a study on the appearance of hemolytic complement activity in the sera of embryonic sheep. Whole complement activity in sera of fetal lambs discovered after the 123rd day of gestation; Description of the hemolytic C activity which depends on the presence of all the C components in the serum; Insensitivity of titres of hemolytic C to large variations in the concentration of some of the components.
KW - SHEEP
KW - LIVESTOCK
KW - HEMOLYSIS & hemolysins
KW - IMMUNITY
KW - BLOOD
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 13347662; Colten, H. R. 1; Silverstein, A. M. 1; Bonos, T. 1; Rapp, H. J. 1; Source Information: Sep68, Vol. 15 Issue 3, p459; Subject: SHEEP; Subject: LIVESTOCK; Subject: HEMOLYSIS & hemolysins; Subject: IMMUNITY; Subject: BLOOD; Subject: ANTIGEN-antibody reactions; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Bering, Edgar A, Jr
T1 - Critical reviews: the sponsor's point of view
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1968/11//
VL - 8
IS - 4
M3 - Article
SP - 236
EP - 237
SN - 00219576
AB - The major items which the sponsor of critical reviews must consider include: (1) the audience for whom the review is produced, (2) the selection of the subject and the scope of the review, (3) the method of production of a review, and (4) distribution of the completed product. The audience any given sponsor serves will, to some degree, determine the subject and scope of the reviews he might sponsor. The general methods of production are the single individual, special workshop, or large symposium. The distribution can be done by one of several methods, but will probably be dictated by the audience and the resources available.
N1 - Accession Number: ISTA0401312; Bering, Edgar A, Jr 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: November 1968, Vol. 8 Issue 4, p236; Note: Update Code: 0400; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Gart, John J.
T1 - Statistics for Biologists (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1968/12//
VL - 63
IS - 324
M3 - Book Review
SP - 1540
SN - 01621459
AB - Reviews the book "Statistics for Biologists," by R.C. Campbell.
KW - STATISTICS
KW - NONFICTION
KW - CAMPBELL, R. C.
KW - STATISTICS for Biologists (Book)
N1 - Accession Number: 4608253; Gart, John J. 1; Affiliations: 1: National Cancer Institute; Issue Info: Dec68, Vol. 63 Issue 324, p1540; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: STATISTICS for Biologists (Book); People: CAMPBELL, R. C.; Number of Pages: 2/3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Oppenheim, J. J.
AU - Rogentine, G. N.
AU - Terry, W. D.
T1 - The Transformation of Human Lymphocytes by Monkey Antisera to Human Immunoglobulins.
JO - Immunology
JF - Immunology
Y1 - 1969/01//
VL - 16
IS - 1
M3 - Article
SP - 123
EP - 138
SN - 00192805
AB - Cultures of human peripheral leucocytes were stimulated to incorporate tritiated thymidine when incubated with monkey antisera to human immunoglobulins. Twenty-five of forty-four monkey antisera were active and stimulated 90 per cent of leucocyte (WBC) cultures to incorporate a small but significantly greater amount of tritiated thymidine (TdR3H) than that incorporated by controls. This stimulation of TdR3H uptake correlated with an increase from 2 to 8 per cent lymphoblasts in the cultures. Leucocytes washed free of serum immunoglobulins responded to a greater degree to the anti-immunoglobulin sera than when they were cultured in the presence of human serum. Prior absorption of antisera with either whole serum or homologous immunoglobulin blocked anti-serum stimulation completely. The anti-IgG and anti-IgM antisera were consistently more effective than anti-IgA, anti-K and anti-A chain antisera. Sequential stimulation by antisera against two different immunoglobulins was not significantly different from those stimulated by only one of the two, Lymphocytes from three asymptomatic subjects with low or absent serum IgA levels transformed as well with anti-IgA as did lymphocytes from subjects with normal serum IgA levels. Antisera were cytotoxic to the lymphocytes only in the presence of complement. Presumably the transformation of human lymphocytes was due to a reaction of anti-immunoglobulin antisera with specific immunoglobulin antigenic determinants present on or in the circulating lymphocytes.
KW - LEUCOCYTES
KW - IMMUNE serums
KW - IMMUNOGLOBULINS
KW - BLOOD cells
KW - LYMPHOCYTES
KW - IMMUNOLOGY
N1 - Accession Number: 13350488; Oppenheim, J. J. 1; Rogentine, G. N. 1; Terry, W. D. 1; Source Information: Jan69, Vol. 16 Issue 1, p123; Subject: LEUCOCYTES; Subject: IMMUNE serums; Subject: IMMUNOGLOBULINS; Subject: BLOOD cells; Subject: LYMPHOCYTES; Subject: IMMUNOLOGY; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Caponio, Joseph F
T1 - Ninds neurological information network
JO - In North, Jeanne B., Ed. Proceedings Of The American Society For Information Science. Volume 6. 32nd Annual Meeting, San Francisco, California, October 1-4, 1969. 1969. Greenwood Publishing Corporation, Westport, Conn.; London, England. P. 447-452. 0 Ref
JF - In North, Jeanne B., Ed. Proceedings Of The American Society For Information Science. Volume 6. 32nd Annual Meeting, San Francisco, California, October 1-4, 1969. 1969. Greenwood Publishing Corporation, Westport, Conn.; London, England. P. 447-452. 0 Ref
Y1 - 1969///
M3 - Book
AB - This paper describes the neurological information network supported by the national institute of neurological diseases and stroke. The network is composed of the following four centers: the parkinson information center; the brian information service; the information center for hearing, speech and disorders of human communication; and the vision information center. The work of the centers is coordinated by a committee which also serves as the focal point for interaction. The ninds information network is dedicated to the following objectives: 1) acquisition, screening, abstracting, indexing and compliation of current citations; 2) preparing state-of-the-art reports, cirtical reviews, and exhibits; 3) sponsoring and conducting ad hoc workshops and symposia; and 4) answering requests for specific information on neuro-sensory diseases.
N1 - Accession Number: ISTA0401954; Caponio, Joseph F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1969; Note: Update Code: 0400; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Schneider, John H
T1 - Design of a comprehensive information system based on linear hierarchical decimal classifications
JO - In Schultz. Louise, Ed. Proceedings Of The Sixth Annual National Colloquium On Information Retrieval. 1969. Medical Documentation Service, College Of Physicians, Philadelphia. P. 99-105. 8 Ref
JF - In Schultz. Louise, Ed. Proceedings Of The Sixth Annual National Colloquium On Information Retrieval. 1969. Medical Documentation Service, College Of Physicians, Philadelphia. P. 99-105. 8 Ref
Y1 - 1969///
M3 - Book Chapter
AB - After stating the advantages of using classifications rather than thesauri as the basis for modern retrieval systems, this paper describes a single-hit method of matching users against documents. The value of a single-hit matching for classification-based selective dissemination of biomedical information (s.d.i.) has been demonstrated. Use of the classification for retrospective retrieval, for on-line searching by users, and for preparation of indexes, current-awareness bulletins, and bibliographies, is proposed. Types of files and operations required for a comprehensive classification-based information system are identified. A pl/1 program has been written which uses an ibm 360/50 system for automated updating and maintenance of linear hierarchical classifications.
N1 - Accession Number: ISTA0600781; Schneider, John H 1; Affiliations: 1 : National Cancer Institute; Source Info: 1969; Note: Update Code: 0600; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Marshall, J. R.;
AU - Jacobson, A.;
AU - Hammond, C. B.;
T1 - Dose response relationships of ovulation induction with human menopausal gonadotropin (HMG)
CT - Dose response relationships of ovulation induction with human menopausal gonadotropin (HMG)
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1969/01/01/
VL - 29
IS - Jan
SP - 106
EP - 110
AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-0269; Language: English; References: 9; Journal Coden: JCEMAZ; Section Heading: Pharmacology
N2 - The relationship between dose of HMG and induction of ovulation has been studied during 178 cycles in 29 anovulatory or oligo-ovulatory women. HMG was started at subovulatory doses and increased in subsequent cycles until ovulation resulted. The first HMG dose causing ovulation was called the first ovulatory dose. The ratio of the actual dose used to the first ovulatory dose was called the relative dose. Subovulatory responses were rated for estrogen effect according to cervical mucus response. Ovulation was determined by BBT, clinical response, urinary pregnanediols and endometrial biopsy. Ovarian size was estimated by pelvic examination. Ovulation was induced in 82 cycles in 28 women. Thirteen patients conceived; one set of twins was the only multiple pregnancy. Absolute HMG dose was positively related to subovulatory response. Examination of response as a function of relative dose significantly decreased variability. Relative dose was positively related to subovulatory response, ovulatory response rate and ovarian enlargement rate. Oligo-ovulatory patients had lower thresholds to HMG than did anovulatory patients; however, sensitivity was not different. Ovulatory rate was independent of duration of therapy or response in preceding cycles and was stable at a rate determined by HMG dose. Results demonstrate the consistency of response to gonadotropins and provide a basis for minimizing hazards of therapy.
KW - Gonadotropins--human menopausal--relationship between dose and induction of ovulation;
KW - Dosage--gonadotropins--human menopausal, relationship to ovulation induction;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Feeley, J. C.;
AU - Roberts, C. O.;
T1 - Immunological responses of laboratory animals to cholera vaccines, toxin and toxoid
CT - Immunological responses of laboratory animals to cholera vaccines, toxin and toxoid
JO - Tex. Rep. Biol. Med.
JF - Tex. Rep. Biol. Med.
Y1 - 1969/01/01/
VL - 27
IS - Suppl 1
SP - 213
EP - 226
AD - Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3922; Language: English; References: 37; Journal Coden: TRBMAY; Section Heading: Pharmacology; Microbiology; Abstract Author: Harvey A. K. Whitney, Jr.
N2 - The capabilities of conventional cholera vaccine and experimental vaccines, toxins and toxoids to induce antibody against the permeability factor (PF) toxin of Vibrio cholera were examined in guinea pigs and rabbits. Vaccines from 4 U. S. licensed manufacturers were assayed by the mouse protection test and were used to immunize guinea pigs. The animals were skin tested with graded doses of PF toxin. Rabbits were hyperimmunized with 3 of the vaccines. Crude Syncase toxin filtrate was converted to toxoid by 2 methods and used to immunize guinea pigs. With the exception of recent lots of vaccine produced by a single manufacturer, conventional cholera vaccines are lacking in detectable PF toxin and do not seem capable of stimulating an antitoxic response against this antigen in guinea pigs or rabbits. Experimental living and formalinized whole-cell vaccines and supernatants from these vaccines were capable of inducing antitoxin and dermal resistance to PF toxin. Toxoids were 3-5 times more antigenic in stimulating antitoxin than the parent toxin. The possible significance of the toxin antigen in formulating a more effective cholera vaccine for immunization was discussed.
KW - Cholera vaccines--antibody induction-;
KW - Immunology--immunological response--antibody induction, against permeability factor toxin of Vibrio cholera, in animals;
KW - Vaccines--immunological responses--induce antibody against permeability factor toxin of Vibrio cholera, in animals;
KW - Toxins--antibody induction--against permeability factor toxin of Vibrio cholera;
KW - Toxoids--antibody induction--against permeability factor toxin of Vibrio cholera;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3922&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-40702-024
AN - 2013-40702-024
AU - Wiener, Jack
T1 - Mental health highlights.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1969/01//
VL - 39
IS - 1
SP - 146
EP - 149
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40702-024. Partial author list: First Author & Affiliation: Wiener, Jack; Center for Studies of Mental Health and Social Problems, Applied Research Branch, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Rehabilitation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1969.
AB - This article present mental health highlights, which focuses on Education Assistance Act, Rehabilitation Amendments, Juvenile Delinquency Prevention and Control Act, Health Manpower Act, new cure for hysteria and many more topics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health highlights
KW - education assistance
KW - rehabilitation amendments
KW - health manpower
KW - 1969
KW - Mental Health
KW - Rehabilitation
KW - 1969
DO - 10.1111/j.1939-0025.1969.tb00629.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40702-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Foley, T. H.;
AU - Bennett, J. M.;
AU - Carbone, P. P.;
T1 - Combination chemotherapy in accelerated phase of chronic granulocytic leukemia
CT - Combination chemotherapy in accelerated phase of chronic granulocytic leukemia
JO - Archives of Internal Medicine (USA)
JF - Archives of Internal Medicine (USA)
Y1 - 1969/02/01/
VL - 123
IS - Feb
SP - 166
EP - 172
SN - 00039926
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1141; Language: English; Chemical Name: Prednisone--53-03-2 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Vincristine--57-22-7; References: 8; Journal Coden: AIMDAP; Section Heading: Drug Evaluations; Abstract Author: Zina Fediay
N2 - With the demonstration of the efficacy of combination chemotherapy in acute leukemia, both lymphocytic and granulocytic, a study was undertaken to assess the value of such therapy in blast crisis. Thirteen patients, 16 to 68 years of age, with chronic granulocytic leukemia, were treated with prednisone, methotrexate, and mercaptopurine. Vincristine sulfate was added to the regimen for 5 patients. All drugs were given intravenously daily for 5 consecutive days. Only one complete clinical remission was seen and there were 2 partial remissions. The toxicity was severe and included 4 drug-related deaths.
KW - Prednisone--leukemia-;
KW - Methotrexate--leukemia-;
KW - Mercaptopurine--leukemia-;
KW - Vincristine--sulfate-;
KW - Drugs--combined therapy--in accelerated phase of chronic granulocytic leukemia;
KW - Antineoplastic agents--combined therapy--in accelerated phase of chronic granulocytic leukemia;
KW - Toxicity--antineoplastic agents--combined therapy, in accelerated phase of chronic granulocytic leukemia;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - King, Kaitung
AU - Bailar III, John C.
T1 - THE HEALTH OF THE CLERGY: A REVIEW OF DEMOGRAPHIC LITERATURE.
JO - Demography
JF - Demography
Y1 - 1969/02//
VL - 6
IS - 1
M3 - Article
SP - 27
EP - 43
SN - 00703370
AB - A combination of special studies and official statistics permits an evaluation of the health of the clergy over the past century. The mortality experience of clergymen has been consistently more favorable than that of the general male population. It also has been favorable in comparison with the experience of men in the legal and medical professions although this differential has been diminishing. The initially favorable position of the clergy relative to teachers has been reversed. There is some evidence of mortality differentials within the clerical profession by major faith, denomination, or ministerial specialty. Clergymen have a relatively high mortality rate from cardiovascular- renal diseases and malignancies, but a very low rate for non-degenerative diseases and suicide. Morbidity statistics for the clergy are fragmentary. They may be over-represented among persons hospitalized for conditions that are emotional in origin. The clergy has some special advantages for studies of health, primarily that both membership in the study population and mortality can be determined with comparative ease. Several areas of future research are suggested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEMOGRAPHY
KW - STATISTICS
KW - MORTALITY
KW - CLERGY
KW - POPULATION
KW - DISEASES
N1 - Accession Number: 16798812; King, Kaitung 1; Bailar III, John C. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014, and Department of Community Medicine and International Health, Georgetown University Medical School, Washington, D.C. 20007.; 2: National Cancer Institute, Bethesda, Maryland 20014.; Issue Info: Feb1969, Vol. 6 Issue 1, p27; Thesaurus Term: DEMOGRAPHY; Thesaurus Term: STATISTICS; Subject Term: MORTALITY; Subject Term: CLERGY; Subject Term: POPULATION; Subject Term: DISEASES; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Bever, Arley T
T1 - The duality of quick and archival communication
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1969/02//
VL - 9
IS - 1
M3 - Article
SP - 3
EP - 6
SN - 00219576
AB - The relative strengths and weaknesses are discussed of formalized, centralized preprint exchanges when organized around a profile of interest, phenomenon, or problem area. The advantages and disadvantages are contrasted with those of the conventional journal system. A complementary set of virtues and weaknesses for the two modes raises the suggestion that scientific societies and journals should investigate formalized preprint exchanges as an extension of present scientific communication mechanisms. The observations are based upon the six-year experience of the information exchange groups program in biomedical areas of the national institutes of health.
N1 - Accession Number: ISTA0502081; Bever, Arley T 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: February 1969, Vol. 9 Issue 1, p3; Note: Update Code: 0500; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Connor, Robert J.
AU - Mosimann, James E.
T1 - CONCEPTS OF INDEPENDENCE FOR PROPORTIONS WITH A GENERALIZATION OF THE DIRICHLET DISTRIBUTION.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1969/03//
VL - 64
IS - 325
M3 - Article
SP - 194
SN - 01621459
AB - Concepts of independence for nonnegative continuous random variables, X[sub 1],..., X[sub k], subject to the constraint SIGMA X[sub i] = 1 are developed. These concepts provide a means of modeling random vectors of proportions which is useful in analyzing certain kinds of data; and which may be of interest in quantifying prior opinions about multinomial parameters. A generalization of the Dirichlet distribution is given, and its relation to the Dirichlet is simply indicated by means of the concepts. The concepts are used to obtain conclusions of biological interest for data on bone composition in rats and scute growth in turtles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANDOM variables
KW - DISTRIBUTION (Probability theory)
KW - STATISTICS
KW - PROBABILITY theory
KW - INDEPENDENCE (Mathematics)
KW - DIRICHLET principle
KW - GENERALIZATION
KW - BIOLOGICAL assay
KW - VARIABLES (Mathematics)
N1 - Accession Number: 4603649; Connor, Robert J. 1; Mosimann, James E. 1; Affiliations: 1: National Institutes of Health, Public Health Service; Issue Info: Mar1969, Vol. 64 Issue 325, p194; Thesaurus Term: RANDOM variables; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: INDEPENDENCE (Mathematics); Subject Term: DIRICHLET principle; Subject Term: GENERALIZATION; Subject Term: BIOLOGICAL assay; Subject Term: VARIABLES (Mathematics); Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
T1 - PSYCHOPHYSIOLOGY OF CONDITIONED EMOTIONAL DISTURBANCES IN HUMANS.
AU - Frazier, Thomas W.
AU - Weil-Malherbe, Hans
AU - Lipscomb, Harry S.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1969/03//
VL - 5
IS - 5
SP - 478
EP - 503
SN - 00485772
N1 - Accession Number: 11237629; Author: Frazier, Thomas W.: 1 Author: Weil-Malherbe, Hans: 2 Author: Lipscomb, Harry S.: 3 ; Author Affiliation: 1 Walter Reed Army Institute of Research.: 2 National Institute of Mental Health, St. Elizabeth's Hospital.: 3 Baylor University College of Medicine.; No. of Pages: 26; Language: English; Publication Type: Article; Update Code: 20031223
N2 - A discriminative avoidance conditioning technique was used to study urinary excretion of selected adrenal hormones in response to a stimulus which had acquired conditioned noxious properties through association with availability of punishment. A four day test procedure was employed: (1) to habituate subjects to the test environment; (2) obtain control data; (3) condition subjects; and (4) test reactions to the conditioned noxious stimulus. Urine samples were taken at two-hour intervals preceding and following each of the four trials, and were analyzed for epinephrine, norepinephrine, total 17-hydroxycorticosteroids, and other urinary constituents. These results were correlated with results obtained from monitoring of heart rate, skin resistance, blood pressure, and three measures of panel monitoring performance. Data analyses revealed significant changes from control levels during the test period for each of the principal measures described above and some specification of life systems interrelationships through correlation and factor analyses. Factors were identified which related to behavioral efficiency, psychological effort, fluid transport regulation, cardiovascular-adrenal, and specific epinephrine and norepinephrine factors. ABSTRACT FROM AUTHOR
KW - *ADRENAL cortex
KW - VIGILANCE (Psychology)
KW - AUTONOMIC conditioning
KW - PUNISHMENT (Psychology)
KW - Adrenal
KW - Autonomic
KW - Factor analysis
KW - Human avoidance conditioning
KW - Punishment. (T. Frazier)
KW - Vigilance
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11237629&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - CONF
AU - Cox, Jackee
T1 - Health Aspects of the International Movement of Animals.
JO - BioScience
JF - BioScience
Y1 - 1969/04//
VL - 19
IS - 4
M3 - Proceeding
SP - 370
EP - 371
SN - 00063568
AB - The article discusses the highlights of the Inter-American Symposium on Health Aspects of the International Movement of Animals that was held on August 28-30, 1968 in San Antonio, Texas. The symposium, co-sponsored by the Pan American Health Organization and the Conference of Public Health Veterinarians, discussed human health problems arising from animal diseases, including the dangers posed by diseases directly transmissible to man from animals. Among the speakers was Abraham Horwitz, president of the Pan American Health Organization.
KW - Conferences & conventions
KW - Animal health -- Congresses
KW - San Antonio (Tex.)
KW - Texas
KW - Pan American Health Organization -- Congresses
N1 - Accession Number: 32757014; Cox, Jackee 1; Affiliations: 1 : Division of Research, Facilities and Resources, National Institutes of Health, Bethesda, Md.; Source Info: Apr1969, Vol. 19 Issue 4, p370; Subject Term: Conferences & conventions; Subject Term: Animal health -- Congresses; Subject: San Antonio (Tex.); Subject: Texas; Number of Pages: 2p; Document Type: Proceeding
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
TY - GEN
AU - Miller, J. R.;
AU - Helprin, J. J.;
AU - Finlayson, J. S.;
T1 - Silicone lubricant flushed from disposable syringes: determination by atomic absorption spectrophotometry
CT - Silicone lubricant flushed from disposable syringes: determination by atomic absorption spectrophotometry
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/04/01/
VL - 58
IS - Apr
SP - 455
EP - 456
SN - 00223549
AD - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0830; Language: English; References: 4; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Technology; Abstract Author: D. R. Tousignaut
N2 - Amounts of silicone removable from disposable plastic syringes were determined (as silicone) by the use of atomic absorption spectrophotometry. This method revealed that the silicone fluid employed as a lubricant was present in distilled water expressed from 20 to 60% of the syringes. As contrasted with the total silicone extractable by dissolving with methyl isobutyl ketone, water-removable silicone appeared to be removed by a mechanical flushing action. The ability of water to remove appreciable quantities of silicone correlated with the presence of local accumulations of silicone lubricant on the plunger tip. However, owing to the translucent nature of plastic syringes, these accumulations are only detectable by visual inspection after removal of the plunger from the barrel. Inasmuch as disposable syringes are packaged in a sterile and assembled condition, removal of the plunger for inspection would be impractical for aseptic use.
KW - Silicone--lubricants-;
KW - Lubricants--silicone--syringes, disposable, atomic absorption spectrometry;
KW - Syringes--disposables--lubricants, silicone, atomic absorption spectrometry;
KW - Disposables--syringes--lubricants, silicone, atomic absorption spectrometry;
KW - Spectrometry, atomic absorption--silicone--lubricants, flushed from disposable syringes;
KW - Plastics--syringes--disposable, silicone lubricant flushed from, atomic absorption spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ager, J. H.;
AU - May, E. L.;
T1 - New compounds: oxazolidines and derived amino alcohols
CT - New compounds: oxazolidines and derived amino alcohols
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/04/01/
VL - 58
IS - Apr
SP - 499
EP - 500
SN - 00223549
AD - Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1004; Language: English; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
KW - Oxazolidines--and derived amino alcohols--new compounds;
KW - Alcohols--derived amino--and oxazolidines, new compounds;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1004&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-40692-011
AN - 2013-40692-011
AU - Wender, Paul H.
T1 - The role of genetics in the etiology of the schizophrenias.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1969/04//
VL - 39
IS - 3
SP - 447
EP - 458
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Wender, Paul H., Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US
N1 - Accession Number: 2013-40692-011. PMID: 4891115 Partial author list: First Author & Affiliation: Wender, Paul H.; Laboratory of Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1968, Chicago, IL, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Etiology; Genetics; Mental Disorders; Psychopathology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1969.
AB - Both experiential and genetic factors have been implicated in the etiology of schizophrenia but their relative roles have been impossible to assess. Recent studies using the technique of adoption to separate the effects of 'nature' and 'nurture' have shown that genetic factors play an important role in the etiology of schizophrenia and may also play a role in the development of other psychiatric illnesses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genetics
KW - etiology
KW - schizophrenia
KW - psychiatric illnesses
KW - psychopathology
KW - 1969
KW - Etiology
KW - Genetics
KW - Mental Disorders
KW - Psychopathology
KW - Schizophrenia
KW - 1969
DO - 10.1111/j.1939-0025.1969.tb00640.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40692-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40692-013
AN - 2013-40692-013
AU - Pedersen, Frank A.
AU - Robson, Kenneth S.
T1 - Father participation in infancy.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1969/04//
VL - 39
IS - 3
SP - 466
EP - 472
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Pedersen, Frank A., National Institute of Child Health and Human Development, Building 1 2A, Room 3001, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-40692-013. PMID: 5783741 Partial author list: First Author & Affiliation: Pedersen, Frank A.; National Institutes of Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1968, Chicago, IL, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Childhood Development; Father Child Relations; Fathers; Parenting. Minor Descriptor: Social Behavior. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Interview; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 1969.
AB - Although the importance of paternal influence on child development is now generally accepted, we actually know very little about normal father-infant relationships. This study, undertaken to define some of them, found a wide variation among a homogeneous middle-class group. No factor was consistent for infants of both sexes. But results showed enough significant correlations to support the need for more developmental studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - father participation
KW - child development
KW - father infant relationships
KW - social behavior
KW - parenting
KW - 1969
KW - Childhood Development
KW - Father Child Relations
KW - Fathers
KW - Parenting
KW - Social Behavior
KW - 1969
DO - 10.1111/j.1939-0025.1969.tb00642.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40692-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Bonadonna, G.;
AU - Monfardini, S.;
T1 - Cardiac toxicity of daunorubicin
CT - Cardiac toxicity of daunorubicin
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1969/04/19/
VL - 1
IS - Apr 19
SP - 837
SN - 00237507
AD - Clinical Chemotherapy Unit, National Cancer Institute, Milan, Italy
N1 - Accession Number: 7-2673; Language: English; References: 7; Journal Coden: LANCAO; Section Heading: Adverse Drug Reactions; Abstract Author: Lamar Orr
N2 - Acute cardiac failure and death occurred in 5 of 16 patients, average age 54 years, receiving total doses of daunorubicin (daunomycin) as low as 300-600 mg. The myocardium of adults and especially that of elderly patients is doubtless more vulnerable to the toxic effects of the drug than is that of children
KW - Daunomycin--toxicity-;
KW - Toxicity--daunomycin--cardiac;
KW - Drugs, adverse reactions--daunomycin--cardiac toxicity;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2673&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bunney, W. E.;
AU - Janowsky, D. S.;
AU - Goodwin, F. K.;
AU - Davis, J. M.;
AU - Brodie, H. K. H.;
T1 - Effect of L-dopa on depression
CT - Effect of L-dopa on depression
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1969/04/26/
VL - 1
IS - Apr 26
SP - 885
EP - 886
SN - 00237507
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0180; Language: English; References: 9; Publication Type: Letters to the Editor; Journal Coden: LANCAO; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2 - A clear reversal of the symptoms of depression was demonstrated in a 56-year-old woman with large doses of L-dopa administered orally. The observed effect indicates that some depressions may be associated with a functional deficit of brain noradrenaline and/or dopamine.
KW - Dopa--L--;
KW - Antidepressants--L-dopa--symptoms reversed;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0180&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Eddy, N. B.;
AU - Friebel, H.;
AU - Hahn, K.-J.;
AU - Halbach, H.;
T1 - Codeine and its alternates for pain and cough relief. Part 4. Potential alternates for cough relief
CT - Codeine and its alternates for pain and cough relief. Part 4. Potential alternates for cough relief
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1969/05/01/
VL - 40
IS - May
SP - 639
EP - 719
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0699; Language: English; Chemical Name: Codeine--6059-47-8; References: 456; Journal Coden: BWHOA6; Section Heading: Pharmacology
N2 - In this report, the fourth of a series on codeine and its alternates for pain and cough relief, an attempt is made to evaluate, on the basis of experimental and clinical data, and wherever possible in comparison with codeine, the effectiveness of a number of antitussive substances currently in clinical use. In the discussion of the undesired side effects particular attention is paid to the risk of dependence and abuse.
KW - Codeine--alternative therapy-;
KW - Toxicity--codeine--risk of dependence and abuse, WHO report;
KW - Dependence--codeine--risks, WHO report;
KW - Drug abuse--codeine--risks, WHO report;
KW - Expectorants and cough preparations--alternatives for codeine--in cough relief, WHO report;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0699&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Eddy, N. B.;
AU - Friebel, H.;
AU - Hahn, K.-J.;
AU - Halbach, H.;
T1 - Codeine and its alternatives for pain and cough relief. Part 5. Discussion and summary
CT - Codeine and its alternatives for pain and cough relief. Part 5. Discussion and summary
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1969/05/01/
VL - 40
IS - May
SP - 721
EP - 730
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0990; Language: English; Chemical Name: Codeine--6059-47-8; References: 18; Journal Coden: BWHOA6; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2 - A discussion on the value of an alternate for codeine concludes a series of articles on the effectiveness and lack of undesirable side effects of several different drugs. It is felt that other substances are available which could be used as alternates for codeine, except where analgesia, cough relief, and sedation are required simultaneously; however, no particular gain and probably no particular loss would result.
KW - Codeine--alternative therapy-;
KW - Toxicity--codeine--risk of dependence and abuse, WHO report;
KW - Dependence--codeine--risks, WHO report;
KW - Drug abuse--codeine--risks, WHO report;
KW - Expectorants and cough preparations--alternatives for codeine--in pain and cough relief, WHO report;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0990&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levey, G. S.;
AU - Roth, J.;
AU - Pastan, I.;
T1 - Effect of propranolol and phentolamine on canine and bovine responses to TSH
CT - Effect of propranolol and phentolamine on canine and bovine responses to TSH
JO - Endocrinology
JF - Endocrinology
Y1 - 1969/05/01/
VL - 84
IS - May
SP - 1009
EP - 1015
AD - Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1207; Language: English; Chemical Name: Propranolol--525-66-6 Phentolamine--50-60-2; Journal Coden: ENDOAO; Section Heading: Pharmacology
KW - Propranolol--and phentolamine-;
KW - Phentolamine--and propranolol-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Goldsmith, Harold F.
AU - Stockwell, Edward G.
T1 - Interrelationship of Occupational Selectivity Patterns Among City, Suburban and Fringe Areas of Major Metropolitan Centers.
JO - Land Economics
JF - Land Economics
Y1 - 1969/05//
VL - 45
IS - 2
M3 - Article
SP - 194
PB - University of Wisconsin Press
SN - 00237639
AB - The article focuses on the interrelationship of occupational selectivity patterns among city, suburban and fringe areas of major metropolitan centers. The analysis reported in the paper is based on the occupational distributions of employed white male non-farm workers within the 76 metropolitan areas that had populations of 300,000 or more. In order to ascertain the occupational selectivity patterns of city, sub-urban and fringe resident populations, Standard Metropolitan Statistical Areas (SMSAs) were divided into zones or sub-areas as follows, the central city of an SMSA is identified as the city, the part of the urbanized area outside the central city is identified as the suburb and the area outside the urbanized area but within the SMSA is referred to as the fringe. Occupational selectivity refers to the differential residential distributions of persons in the major occupation classes. it was found that metropolitan areas with central cities in which the higher status white collar occupations were under-represented and the lower status white collar occupations usually were over-represented tended to have suburban areas in which the higher status white collar occupations were over represented and lower-status blue collar occupations were under-represented.
KW - Labor market
KW - Occupational prestige
KW - Occupations -- United States
KW - Standard metropolitan statistical areas
KW - Blue collar workers
KW - White collar workers
KW - White collar workers -- United States
KW - Employee selection
KW - Metropolitan areas -- United States
KW - Metropolitan areas
KW - United States
N1 - Accession Number: 5364524; Goldsmith, Harold F. 1; Stockwell, Edward G. 2; Affiliations: 1: Chief, Population Research Section, Mental Health Study Center, National Institute of Mental Health.; 2: Professor of Rural Sociology, University of Connectient.; Issue Info: May69, Vol. 45 Issue 2, p194; Subject Term: Labor market; Subject Term: Occupational prestige; Subject Term: Occupations -- United States; Subject Term: Standard metropolitan statistical areas; Subject Term: Blue collar workers; Subject Term: White collar workers; Subject Term: White collar workers -- United States; Subject Term: Employee selection; Subject Term: Metropolitan areas -- United States; Subject Term: Metropolitan areas; Subject: United States; Number of Pages: 12p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Evan, William M.
AU - Simmons, Roberta G.
T1 - Organizational Effects of Inequitable Rewards: Two Experiments in Status Inconsistency.
JO - Administrative Science Quarterly
JF - Administrative Science Quarterly
Y1 - 1969/06//
VL - 14
IS - 2
M3 - Article
SP - 224
EP - 237
PB - Administrative Science Quarterly
SN - 00018392
AB - Two organizational experiments were conducted to investigate the effects of overpayment and underpayment. Subjects were confronted with one of two organizational sources of inequitable payment. In one experiment their salary was inconsistent with their officially recognized level of competence; in another, their salary was inconsistent with their level of authority. Students were hired as proofreaders and worked in the actual offices of a publishing company. Status inconsistency was found to exert a significant effect on performance and to a lesser extent on conformity to organizational rules. Underpaid subjects behaved in accordance with equity theory by producing work of a lower level of quality; however, overpaid subjects did not behave consistently with the theory. [ABSTRACT FROM AUTHOR]
AB - Copyright of Administrative Science Quarterly is the property of Administrative Science Quarterly and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAYMENT
KW - COMPENSATION management
KW - OVERPAYMENT
KW - PAY equity
KW - WAGE payment systems
KW - WAGES
KW - EQUAL pay for equal work
KW - ORDINARY income
KW - EARNED income
KW - LABOR costs
KW - INCOME
KW - PERFORMANCE
N1 - Accession Number: 4026768; Evan, William M. 1; Simmons, Roberta G. 2; Affiliations: 1: professor of sociology and industry, University of Pennsylvania; 2: special faculty research fellow, national institutes of health, laboratory of research in social relations, University of Minnesota; Issue Info: Jun69, Vol. 14 Issue 2, p224; Thesaurus Term: PAYMENT; Thesaurus Term: COMPENSATION management; Thesaurus Term: OVERPAYMENT; Thesaurus Term: PAY equity; Thesaurus Term: WAGE payment systems; Thesaurus Term: WAGES; Thesaurus Term: EQUAL pay for equal work; Thesaurus Term: ORDINARY income; Thesaurus Term: EARNED income; Thesaurus Term: LABOR costs; Thesaurus Term: INCOME; Subject Term: PERFORMANCE; NAICS/Industry Codes: 541612 Human Resources Consulting Services; Number of Pages: 14p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
T1 - 1-Methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide
CT - 1-Methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/06/01/
VL - 29
IS - Jun
SP - 1226
EP - 1232
SN - 00085472
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-0673; Language: English; Chemical Name: Urea--57-13-6; References: 38; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - 1-Methyl-1-nitrosourea (MNU), the active moiety of the streptozotocin molecule, produces a dose-related depression of nicotinamide adenine dinucleotide (NAD) concentrations in mouse liver and L1210 ascites, similar to that produced by streptozotocin. Pretreatment with nicotinamide prevented the decrease in NAD; however, it did not influence either the toxicity or antineoplastic activity of MNU.
KW - Urea--1-methyl-1-nitroso--;
KW - Nicotinamide--prevention of 1-methyl-1-nitrosourea produced decrease in nicotinamide adenine dinucleotide-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Goldman, P.;
T1 - Carbon-fluorine bond in compounds of biological interest
CT - Carbon-fluorine bond in compounds of biological interest
JO - Science
JF - Science
Y1 - 1969/06/06/
VL - 164
IS - Jun 6
SP - 1123
EP - 1130
AD - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0536; Chemical Name: Carbon--7440-44-0 Fluorine--7782-41-4; References: 83; Journal Coden: SCIEAS; Section Heading: Pharmaceutical Chemistry; Abstract Author: Robert A. Hall
N2 - The importance of fluorine incorporated into pharmacological agents is related to either its size or its electronegativity. This review article includes discussions of the carbon-fluorine bond in selective inhibition of biological processes and in the design of more active therapeutic agents.
KW - Carbon--fluorine bond-;
KW - Fluorine--carbon bond-;
KW - Bonding--carbon-fluorine--in compounds of biological interest;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Glueck, C. J.;
AU - Brown, W. V.;
AU - Levy, R. I.;
AU - Greten, H.;
AU - Fredrickson, D. S.;
T1 - Amelioration of hypertriglyceridemia by progestational drugs in familial type-V hyperlipoproteinemia
CT - Amelioration of hypertriglyceridemia by progestational drugs in familial type-V hyperlipoproteinemia
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1969/06/28/
VL - 1
IS - Jun 28
SP - 1290
EP - 1291
SN - 00237507
AD - Molecular Disease Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1616; Language: English; Chemical Name: Norethindrone--68-22-4; References: 18; Publication Type: Preliminary Communications; Journal Coden: LANCAO; Section Heading: Drug Evaluations
N2 - Administration of norethindrone acetate resulted in marked clearing of hyperglyceridemia in 4 patients with familial type-V hyperlipoproteinemia. This progestational agent was responsible for a 2-10 fold decrease in plasma triglyceride, and a concurrent increase in post-heparin lipolytic activity. In these cases progestational agents represented new and effective therapy for type-V hyperlipoproteinemia.
KW - Norethindrone--acetate-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Powers, K. G.;
T1 - Activity of chlorinated lincomycin analogs against Plasmodium cynomolgi in rhesus monkeys
CT - Activity of chlorinated lincomycin analogs against Plasmodium cynomolgi in rhesus monkeys
JO - Am. J. Trop. Med. Hyg.
JF - Am. J. Trop. Med. Hyg.
Y1 - 1969/07/01/
VL - 18
IS - Jul
SP - 485
EP - 490
AD - Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-3637; Language: English; Chemical Name: Lincomycin--154-21-2; Therapeutic Class: (8:12); AHFS Class: Antibiotics lincomycin (8:20); AHFS Class: Plasmodicides lincomycin; References: 8; Journal Coden: AJTHAB; Section Heading: Preliminary Drug Testing; Abstract Author: Joan M. Anderson
N2 - Analogs are prepared by substituting chlorine for the hydroxyl group at the 7 position in the amino-sugar moiety of lincomycin or its semi-synthetic derivatives. The resulting compounds are more rapidly absorbed, give higher concentrations in the blood, penetrate tissues more rapidly, and have greater antibacterial activity than their nonchlorinated counterparts. Acute infections were treated by oral or subcutaneous administration for 5 consecutive days with doses ranging from 6.25 mg. to 100 mg./kg. body weight. Cures were obtained when U-21,251F (7-chlorolincomycin) and U-24,729A (7-chloro-N-demethyl-4\DP/-pentyllincomycin) were given orally at 50 mg./kg., and when U-26,285A (7-chloro-N-demethyllincomycin) was given at 100 mg./kg. U-24,729A and U-26,285A were also curative when given subcutaneously at 25 and 50 mg./kg. respectively. With all dosage regimens the blood was cleared of parasites 3 to 6 days after cessation of treatment. The rate of clearance of parasites did not appear to be related to dose. No side effects due to the antibiotics were observed.
KW - Lincomycin--derivatives-;
KW - Antibiotics--lincomycin--derivatives, chlorinated, activity against P. cynomolgi, in rhesus monkeys;
KW - Plasmodicides--lincomycin--derivatives, chlorinated, activity against P. cynomolgi, in rhesus monkeys;
KW - Absorption--lincomycin--derivatives, chlorinated;
KW - Blood levels--lincomycin--derivatives, chlorinated;
KW - Metabolism--lincomycin--derivatives, chlorinated;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wolff, J.;
T1 - Iodide goiter and the pharmacologic effects of excess iodide
CT - Iodide goiter and the pharmacologic effects of excess iodide
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1969/07/01/
VL - 47
IS - Jul
SP - 101
EP - 124
SN - 00029343
AD - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1198; Language: English; References: 280; Journal Coden: AJMEAZ; Section Heading: Pharmacology; Abstract Author: Philip D. Hansten
N2 - This review concerns itself with the effects of excess iodide, i.e., amounts greater than those needed for the production of normal amounts of the thyroid hormones. Drugs which serve, in many cases, as sources of excessive iodide intake are described.
KW - Iodides--excess--iodide goiter and pharmacological effects;
KW - Drugs--excessive iodide intake sources--description;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Paul, W. E.
AU - Thorbecke, G. Jeanette
AU - Siskind, G. W.
AU - Benacerraf, B.
T1 - The Effect of Dose in Tolerance Induction on the Subsequent Response to a Cross-Reactive Antigen.
JO - Immunology
JF - Immunology
Y1 - 1969/07//
VL - 17
IS - 1
M3 - Article
SP - 85
EP - 92
SN - 00192805
AB - The amount of antibody produced by BSA-tolerant rabbits as a result of immunization with DNP-BSA is dependent upon the amount of BSA used to induce tolerance. Tolerance was induced by initial injection of 100 μg of antigen followed by progressively higher doses. Rabbits rendered tolerant with a maximum BSA dose of 1 mg had a mean serum anti-BSA antibody concentration of 0·39 mg/ml after immunization with DNP-BSA, whereas rabbits rendered tolerant with a maximum BSA dose of 100 mg had a mean serum anti-BSA concentration of 0·02 mg after the same course of immunization. This compares with a mean of 1·08 mg of anti-BSA antibody in normal rabbits immunized with DNP-BSA. There was a similar reduction in the concentration of anti-DNP anti-bodies and of conjugate-specific antibodies in the tolerant groups. The results are discussed in terms of a thermodynamically-controlled induction of tolerance in individual precursor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - IMMUNIZATION
KW - RABBITS as laboratory animals
KW - ADMINISTRATION of drugs
KW - CELLS
KW - IMMUNOLOGY
N1 - Accession Number: 13354172; Paul, W. E. 1; Thorbecke, G. Jeanette 1; Siskind, G. W. 1; Benacerraf, B. 1,2,3; Source Information: Jul69, Vol. 17 Issue 1, p85; Subject: IMMUNOGLOBULINS; Subject: IMMUNIZATION; Subject: RABBITS as laboratory animals; Subject: ADMINISTRATION of drugs; Subject: CELLS; Subject: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - White, W. C.;
AU - Allen, S. I.;
AU - Otten, M.;
AU - Swarthe, E.;
T1 - Experimental computer network for medical data processing
CT - Experimental computer network for medical data processing
JO - Methods Inf. Med.
JF - Methods Inf. Med.
Y1 - 1969/07/01/
VL - 8
IS - Jul
SP - 113
EP - 120
AD - Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3563; Language: English; Language of Summary: ger; References: 18; Journal Coden: MIMCAI; Section Heading: Information Processing and Literature
N2 - Methods for supplying medical personnel, especially in isolated areas, with the same sophisticated medical information and computational facilities that are available in major medical centers, were investigated. Inexpensive, readily available input/output terminals, including the push button telephone, were tested with several biomedical application programs. An experimental network, consisting of several independent commercial time-sharing computers linked to user terminals through a small communication control computer, was constructed to demonstrate an efficient and flexible approach to remote computer access. The communication control computer, acting as a message handling and translating interface, allowed the use of a uniform terminal control language and common data handling conventions. By linking to the most powerful commercial time-sharing systems available, a reliable medical data processing network was established without a major investment in computer hardware or system software.
KW - Automation, data processing--computers--experimental system provides economical medical information and computational facilities;
KW - Information--medical--experimental data processing system provides economical service;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Allen, S I
AU - Otten, M
AU - Swarthe, E
T1 - An experimental computer network for medical data processing
JO - Methods of Information in Medicine
JF - Methods of Information in Medicine
Y1 - 1969/07//
VL - 8
IS - 3
M3 - Article
SP - 113
EP - 120
SN - 00261270
AB - Methods for suppling medical personnel, especially in isolated areas, with the same sophisticated medical information and computational facilities that are available in major medical centers were investigated. Inexpensive, readily available input/output terminals, including the pushbutton telephone, were tested with several biomedical application programs. An experimental network, consisting of several independent commercial time-sharing computers linked to user terminals through a small communication control computer, was constructed to demonstrate an efficient and flexible approach to remote computer access. The communication control computer, acting as a message handling and translating interface, allowed the use of a uniform terminal control language and common data handling conventions. By linking to the most powerful commercial time-sharing systems available, a reliable medical data processing network was established without a major investment in computer hardware or system software. This experimental work is a major part of the medical information telecommunication project in the devision of computer research and technology (dcrt) at the national institutes of health
N1 - Accession Number: ISTA0500819; Allen, S I 1; Otten, M; Swarthe, E; Affiliations: 1 : Division Of Computer Research And Technology, National Institutes Of Health.; Source Info: July 1969, Vol. 8 Issue 3, p113; Note: Update Code: 0500; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Meyer, H. M.;
AU - Parkman, P. D.;
AU - Hopps, H. E.;
T1 - Control of rubella
CT - Control of rubella
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1969/07/01/
VL - 44
IS - Jul
SP - 5
EP - 0
SN - 00314005
AD - Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-1124; Language: English; References: 68; Journal Coden: PEDIAU; Section Heading: Drug Evaluations; Pharmacology
N2 - Intranasal challenge of rubella vaccines with natural rubella virus demonstrated that vaccine induced antibodies were protective against the clinical and virologic manifestations of rubella. Observation of vaccinated children over a 3-year period has demonstrated little evidence of a decline in the antibodies. Fully attenuated rubella virus vaccines have not produced significant clinical reactions in children. However, mild rubella-like symptoms have been observed in adult women receiving vaccine; transient rashes, lymphadenopathy, arthralgia, and arthritis have been observed. Since the risk of spread of attenuated virus to the fetus in vaccinated women cannot be readily determined, the use of the vaccine during pregnancy would be potentially hazardous.
KW - Rubella vaccines--rubella control-;
KW - Toxicity--rubella vaccines--risk during pregnancy;
KW - Immunization--rubella--control discussed;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gallo, R. C.;
AU - Whang-Peng, J.;
AU - Perry, S.;
T1 - Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin
CT - Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin
JO - Science
JF - Science
Y1 - 1969/07/25/
VL - 165
IS - Jul 25
SP - 400
EP - 402
AD - Human Tumor Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-1201; Language: English; References: 24; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2 - Isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin-stimulated lymphocyte. The stage of cell cycle and the concentrations used are critical for these effects. The authors suggest isopentenyladenosine might be useful in the treatment of some neoplasias not only for its direct antitumor effects but to help trigger some cells to divide.
KW - Isopentenyladenosine--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kasel, J. A.;
AU - Rossen, R. D.;
AU - Fulk, R. V.;
AU - Fedson, D. S.;
AU - Couch, R. B.;
AU - \ET/;
T1 - Human influenza: aspects of the immune response to vaccination
CT - Human influenza: aspects of the immune response to vaccination
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1969/08/01/
VL - 71
IS - Aug
SP - 369
EP - 398
SN - 00034819
AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-3407; Language: English; References: 99; Publication Type: NIH Clinical Staff Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - The studies presented in this conference illustrate some of the newer aspects of the immune response to infection with influenza virus and vaccination with inactivated vaccines. The predominant immunoglobulin in respiratory secretions is an 11S IgA dimer that is distinguishable from serum IgA. Intranasal immunization with inactivated vaccines resulted in higher titers and greater duration of antibody in respiratory secretions than did subcutaneous vaccination. In addition, if given in adequate dosages, vaccination by this method resulted in significant levels of humoral antibody in most vaccinees. The degree of both serum and nasal antibody responses was shown to be related to the age and prior immunologic experience of the vaccinated individual. Initial studies from challenge experiments suggested that intranasal vaccination was as effective as subcutaneous vaccination in reducing infection.
KW - Influenza vaccines--inactivated-;
KW - Immunization--influenza--aspects of immune response to vaccination;
KW - Drug administration--influenza vaccines--inactivated, intranasal and subcutaneous immunization, aspects of immune response;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Katz, R. I.;
AU - Kopin, I. J.;
T1 - Release of norepinephrine-3H and serotonin-3H evoked from brain slices by electrical field stimulation--calcium dependency and the effects of lithium, ouabain and tetrodotoxin
CT - Release of norepinephrine-3H and serotonin-3H evoked from brain slices by electrical field stimulation--calcium dependency and the effects of lithium, ouabain and tetrodotoxin
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1969/08/01/
VL - 18
IS - Aug
SP - 1935
EP - 1939
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0241; Language: English; Chemical Name: Ouabain--11018-89-6 Lithium--7439-93-2 Tetrodotoxin--4368-28-9 Calcium--7440-70-2; References: 22; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: A. Leon Moore
N2 - Slices of mammalian brain accumulate tritiated norepinephrine or serotonin when incubated in a medium with these compounds; mild electrical stimulation of short duration induces a striking increase in the release of exogenous labeled amine. Electrically stimulated release of norepinephrine-3H, but not of serotonin-3H, is calcium dependent. Stimulation induced release of both monoamines is significantly diminished by the addition of ouabain, lithium or tetrodotoxin to the perfusing medium. Because the effect of lithium on norepinephrine-3H was reversed by augmented calcium concentration, it appears that lithium may act directly or indirectly to interfere with calcium participation in stimulus-release coupling. In contrast to the inhibitory effect of low calcium on the release of norepinephrine-3H from brain slices, the absence of calcium in the superfusate does not appear to interfere with the release of serotonin-3H. Thus it appears that the mechanism of release of serotonin is different from that of norepinephrine. These findings suggest that electrical field stimulation induced release of labeled monoamines from brain slices may serve as a useful model for studying central release mechanisms as well as for detailed observations of the mode of action of drugs affecting the central nervous system.
KW - Ouabain--decrease stimulation induced release of monoamines-;
KW - Lithium--decreases stimulation induced release of monoamines-;
KW - Tetrodotoxin--decreases stimulation induced release of monoamines-;
KW - Calcium--role in release mechanisms of monoamines-;
KW - Central nervous system drugs--mode of action--central release mechanisms studied;
KW - Methodology--electrical field stimulation--central release mechanisms studied, in brain slices;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Suskind, R. G.;
AU - Pry, T. W.;
AU - Rabotti, G. F.;
T1 - Effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition by actinomycin D (dactinomycin)
CT - Effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition by actinomycin D (dactinomycin)
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/08/01/
VL - 29
IS - Aug
SP - 1598
EP - 1605
SN - 00085472
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0765; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Journal Coden: CNREA8; Section Heading: Microbiology
KW - Dactinomycin--effect of Rous sarcoma virus infection on recovery of nucleolar RNA, ribonucleoprotein, and DNA synthesis from inhibition-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frank, M. M.
AU - Humphrey, J. H.
T1 - Spontaneous Re-Aggregation of IgM Subunits and Restoration of Antibody Activity After Reduction and Alkylation of Rabbit Anti-Forssman Antibody.
JO - Immunology
JF - Immunology
Y1 - 1969/08//
VL - 17
IS - 2
M3 - Article
SP - 237
EP - 247
SN - 00192805
AB - Highly purified rabbit IgM anti-Forssman antibody, after reduction in dilute solution with 2-mercaptoethanol and alkylation with iodoacetamide, showed no diminution and often some increase in haemagglutination of sheep erythrocytes. The capacity to cause complement dependent lysis was, however, destroyed. It is shown that despite reduction and alkylation reaggregation of the subunits occurs to a variable extent producing non-covalently bound aggregates with S values ranging from 7 to more than 20. The aggregates can bind specifically to and agglutinate erythrocytes with greater effectiveness as their size increases. This spontaneous re-aggregation is not prevented by the presence of gelatin, but fails to occur when the IgM antibody is reduced in the presence of a variety of other proteins. The effect of extraneous proteins is evident only when they are present at the time of reduction or are added within 10–15 minutes. It is suggested that following rupture of the interchain disulphide bonds, the IgM molecule can undergo a complex, time-dependent rearrangement into new stable forms which retain combining site activity but do not involve covalent bonds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN G
KW - IMMUNOGLOBULINS
KW - CHEMICAL reduction
KW - ALKYLATION
KW - IMMUNOLOGY
KW - PROTEOMICS
N1 - Accession Number: 13355393; Frank, M. M. 1,2; Humphrey, J. H. 3; Source Information: Aug69, Vol. 17 Issue 2, p237; Subject: IMMUNOGLOBULIN G; Subject: IMMUNOGLOBULINS; Subject: CHEMICAL reduction; Subject: ALKYLATION; Subject: IMMUNOLOGY; Subject: PROTEOMICS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Murphy, D. L.;
AU - Goodwin, F. K.;
AU - Bunney, W. E., Jr.;
T1 - Aldosterone and sodium response to lithium administration in man
CT - Aldosterone and sodium response to lithium administration in man
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1969/08/30/
VL - 2
IS - Aug 30
SP - 458
EP - 460
SN - 00237507
AD - Clinical Center, National Institutes of Health, 10-3 S229, Bethesda, Maryland 20014
N1 - Accession Number: 7-2094; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 21; Journal Coden: LANCAO; Section Heading: Pharmacology
N2 - Administration of lithium carbonate to 16 manic-depressive and depressed patients was found to lead to an initial 1-2 days of sodium and water diuresis. In the subsequent 4-5 day period of treatment, sodium retention associated with a 50% increase in aldosterone excretion occurred, followed in the next several days by a return towards prelithium levels. These changes occurred in all patients and were apparently not related to the initial clinical state of the patient nor the presence or absence of symptomatic improvement with lithium.
KW - Lithium carbonate--aldosterone and sodium response-;
KW - Psychotherapeutic agents--lithium carbonate--aldosterone and sodium response;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hirshaut, Y.;
AU - Weiss, G. H.;
AU - Perry, S.;
T1 - Use of long-term human leukocyte cell cultures as models for the study of antileukemic agents
CT - Use of long-term human leukocyte cell cultures as models for the study of antileukemic agents
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/09/01/
VL - 29
IS - Sep
SP - 1732
EP - 1740
SN - 00085472
AD - National Cancer Institute, Building 10, Room 6 B 17, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0785; Language: English; Chemical Name: Mercaptopurine--6112-76-1 Methotrexate--59-05-2 Vincristine--57-22-7 Prednisolone--50-24-8; References: 21; Journal Coden: CNREA8; Section Heading: Methodology
N2 - Long-term human leukocyte cell cultures were exposed to 4 antineoplastic agents to determine the relationship between drug concentration and cell exposure time to cell kill. The drugs tested were mercaptopurine, methotrexate, vincristine, and prednisolone. The studies provide new insight into the concentration-time relationship of the 4 test drugs. The results indicate that long-term human leukocyte culture models may be useful in the evaluation of some factors determining the effectiveness of a drug as a chemotherapeutic agent.
KW - Mercaptopurine--evaluation-;
KW - Methotrexate--evaluation-;
KW - Vincristine--evaluation-;
KW - Prednisolone--evaluation-;
KW - Antineoplastic agents--evaluation--using long-term human leukocyte cell cultures;
KW - Methodology--antineoplastic agents--evaluation using long-term human leukocyte cell cultures;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Adler, W. H.
AU - Curry, Jean H.
AU - Smith, R. T.
T1 - Immunoglobulin Peptidc Chain Synthesis in the Newborn Rabbit.
JO - Immunology
JF - Immunology
Y1 - 1969/09//
VL - 17
IS - 3
M3 - Article
SP - 457
EP - 468
SN - 00192805
AB - Lymphoid tissue from newborn rabbits was examined using fluorochrome conjugated goat antisera to rabbit γ, μ and α heavy chain and mixed light chain. Unimmunizcd newborn rabbits examined at intervals up to 20 days of age revealed a very low background of approximately one in 105 cells which stained with either the anti-μ, anti-γ or anti-L chain reagents. Newborn rabbits, immunized intrapcritoncally on the day of birth with S. paralyphi B (4, 5, 12:b), showed a 1000-fold increase in the number of stained cells; μ heavy chain containing cells were found 16 hours after immunization, and γ heavy chain containing cells were found 20 hours after immunization in the rabbit spleen tissue. The numbers of μ containing cells and γ containing cells were approximately equal at 5 days of age in tile immunized groups. No α heavy chain containing cells were found in any of tile rabbits studied. All cells which stained with the anti-μ or γ heavy chain reagent were also stained with the anti-light chain reagent. The cellular response of the immunized newborn rabbits could be inhibited by passive antibody to S. paralyphi B, either given at the time of immunization, or passively acquired from the doc. Specificity of inhibition was indicated by the failure of sheep red blood cells (SRBG) stroma to be inhibited in animals so suppressed. The range of cellular morphology of the γ chain containing and the μ chain containing cells was indistinguishable. The earliest cell to be stained with either anti-γ or anti-μ was a large blast-like cell with a thin rim of cytoplasm and a large nucleus. A full range of forms between this and typical plasma cells appeared later in each case. These findings present a paradox since γG antibody to this antigen does not appear in the serum of stroll animals following γM class in the usual sequence characteristic of adult animals. Possible explanations of this paradox arc explored. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNIZATION
KW - IMMUNITY
KW - IMMUNOGLOBULINS
KW - PLASMA cells
KW - IMMUNOLOGY
N1 - Accession Number: 14545579; Adler, W. H. 1,2; Curry, Jean H. 1; Smith, R. T. 1; Source Information: Sep69, Vol. 17 Issue 3, p457; Subject: ANTIGENS; Subject: IMMUNIZATION; Subject: IMMUNITY; Subject: IMMUNOGLOBULINS; Subject: PLASMA cells; Subject: IMMUNOLOGY; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - McIntire, K. R.
AU - Princler, G. L.
T1 - Prolonged Adjuvant Stimulation in Germ-Free BALB/c Mice: Development of Plasma Cell Neoplasia.
JO - Immunology
JF - Immunology
Y1 - 1969/09//
VL - 17
IS - 3
M3 - Article
SP - 481
EP - 487
SN - 00192805
AB - BALB/c mice develop a high incidence (60–80 per cent) of plasma cell tumour (PCT) following the introduction of mineral oil (MO) into the peritoneal cavity. Germ-free (GF) mice have a less developed lymphoreticular system, including a decreased number of plasma cells, than their conventional (CONV) counterparts. When GF BALB/c mice were injected i.p. with mineral oil they failed to develop the expected incidence of PCT. Only two of thirty-three GF mice (6 per cent) developed PCT, while twenty-four of thirty-one ex-GF (77 per cent) and twenty-eight of forty CONV BALB/c (70 per cent) developed PCT. The ex-GF and CONV mice had average times for PCT diagnosis of 11.3 and 11.5 months, but both GF tumours were discovered 18 months after mineral oil injection. Three groups of GF mice recieved three different sterile protein antigens along with MO and no PCT developed in these mice; in the GF group receiving MO along, both PCT arose. The GF mice in this experiment did develop a high incidence (80 per cent) of lymphoreticular neoplasms of a type more primitive than PCT. This experiment suggests the importance of microbial flora in the development and differentiation of the plasma cells which respond to a carcinogenic stimulus in a genetically susceptible host. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMA cells
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - MINERAL oils
KW - IMMUNOLOGY
N1 - Accession Number: 14545586; McIntire, K. R. 1; Princler, G. L. 1; Source Information: Sep69, Vol. 17 Issue 3, p481; Subject: PLASMA cells; Subject: ANTIGENS; Subject: IMMUNOGLOBULINS; Subject: MINERAL oils; Subject: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Cornfield, Jerome
AU - Halperin, Max
AU - Greenhouse, Samuel W.
T1 - AN ADAPTIVE PROCEDURE FOR SEQUENTIAL CLINICAL TRIALS.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1969/09//
VL - 64
IS - 327
M3 - Article
SP - 759
SN - 01621459
AB - An adaptive procedure for sequential clinical trials is considered, in which an increasing proportion of patients is assigned to the better of two treatments as evidence for it accumulates. The procedure considered is a multi-stage application of an optimum two-stage procedure. In the first stage of the two-stage procedure patients are assigned to each of two treatments and in the second all are assigned to the apparently better of the two treatments. The optimum two-stage procedure is one in which the proportions assigned to each of the treatments in the first stage, 2p theta and 2p(1-theta), are such as to minimize a certain natural cost function, which depends on information available before the first stage and on the total number of patients to be treated. Multi-stage application consists of recalculating the optimum two-stage theta at each point in the sequential stream of patients and interpreting it as the proportion of the next "small" batch of patients to be assigned to treatment 1. This multi-stage procedure is not optimum but does lead to lower costs than the optimum two-stage procedure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COST control
KW - CLINICAL trials
KW - SEQUENTIAL analysis
KW - GUIDELINES
KW - PATIENTS
KW - EVIDENCE
N1 - Accession Number: 4608152; Cornfield, Jerome 1; Halperin, Max 2; Greenhouse, Samuel W. 2; Affiliations: 1: University of Pittsburgh.; 2: National Institutes of Health.; Issue Info: Sep69, Vol. 64 Issue 327, p759; Thesaurus Term: COST control; Subject Term: CLINICAL trials; Subject Term: SEQUENTIAL analysis; Subject Term: GUIDELINES; Subject Term: PATIENTS; Subject Term: EVIDENCE; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
T1 - SKIN POTENTIAL LEVELS IN RIGHT- AND LEFT-HANDED MALES.
AU - Wyatt, Richard
AU - Tursky, Bernard
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1969/09//
VL - 6
IS - 2
SP - 133
EP - 137
SN - 00485772
N1 - Accession Number: 11049682; Author: Wyatt, Richard: 1 Author: Tursky, Bernard: 2 ; Author Affiliation: 1 National Institute of Mental Health, Bethesda: 2 Massachusetts Mental Health Center; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20031208
N2 - From twelve left-handed and twelve right-handed males, skin potential levels were recorded simultaneously from both sides of the body. In both groups significantly higher skin potential levels were found on the right side. Unilateral stimuli and handedness did not unilaterally affect maximum response level. ABSTRACT FROM AUTHOR
KW - *SKIN
KW - *HANDEDNESS
KW - *PSYCHOPHYSIOLOGY
KW - MALES
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 2006-06122-002
AN - 2006-06122-002
AU - Rosenthal, David
T1 - Whither Human Behavioral Genetics?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1969/09//
VL - 14
IS - 9
SP - 457
EP - 458
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06122-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061030. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavioral Genetics. Minor Descriptor: Psychologists. Classification: Genetics (2510). Population: Human (10). Reviewed Item: Vandenberg, Steven G. (Ed). Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances=Baltimore: Johns Hopkins Press, 1968. Pp. xi + 356. $12.50; 1968. Page Count: 2. Issue Publication Date: Sep, 1969.
AB - Reviews the book, Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances edited by Steven G. Vandenberg (see record [rid]1972-02467-000[/rid]). In this book, author brings together a variety of research contributions by some of the most prominent investigators in the field of human behavior genetics. The contributions fully warrant serious consideration by psychologists, although many who believe that psychology needs to take into account the kinds of organism we are dealing with will not be impressed by the degree of progress represented among them. The concern is that the fancy of psychologists will not be caught by such volumes, and that they may incline toward dismissing out of hand all genetic studies of behavior. Where does such a discipline go? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human behavior genetics
KW - psychologists
KW - 1969
KW - Behavioral Genetics
KW - Psychologists
KW - 1969
U2 - Vandenberg, Steven G. (Ed). (1968); Progress in Human Behavior Genetics: Recent Reports on Genetic Syndromes, Twin Studies, and Statistical Advances; Baltimore: Johns Hopkins Press, 1968. Pp. xi + 356. $12.50
DO - 10.1037/009820
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Newman, S. J.;
AU - Sever, J. L.;
AU - Fuccillo, D. A.;
T1 - Intranasal administration of HPV-77 rubella vaccine grown in WI-38. Lack of infection by this route
CT - Intranasal administration of HPV-77 rubella vaccine grown in WI-38. Lack of infection by this route
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1969/09/27/
VL - 2
IS - Sep 27
SP - 665
EP - 666
SN - 00237507
AD - Perinatal Research Branch, Section on Infectious Diseases, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3863; Language: English; References: 7; Journal Coden: LANCAO; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2 - The HPV-77/WI 6 strain of rubella virus was administered intranasally to 4 susceptible adult males without producing a rise in hemagglutination-inhibiting antibody titer. The results suggest that this particular strain does not produce antibodies when given intranasally. At the same time, the lack of infectivity by this route supports the safety and noncommunicability of this attenuated rubella virus when administered parenterally to susceptible children. The ease of administration by this method, as well as the lack of spread to contact, make intranasal inoculation attractive for future study.
KW - Rubella vaccines--HPV-77/WI 6 strain-;
KW - Drug administration--rubella vaccines--intranasal, HPV-77/WI 6 strain, no rise produced in hemagglutination-inhibiting antibody titer;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kohn, Melvin L.
AU - Schooler, Carmi
T1 - CLASS, OCCUPATION, AND ORIENTATION.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1969/10//
VL - 34
IS - 5
M3 - Article
SP - 659
EP - 678
SN - 00031224
AB - Social class is consistently related to men's values -- both their value: for themselves and those for their children -- and to their orientation to work, society, and self. Basic to all these class relationships is the distinction between self-direction and conformity to external authority, the former more highly valued by men of higher social class position, the hater by men of lower social class position. All these class relationships can be explained as resulting from the cumulative effects of education and occupational position. Education is import ant because it can foster the intellectual flexibility and breadth of perspective required for sell-directed values and orientation. Occupational position is important because it is determinative of the conditions that facilitate or preclude the exercise of self-direction in work. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONS
KW - INTERGROUP relations
KW - SOCIAL classes
KW - CLASS relations
KW - EDUCATION
KW - SOCIAL status
N1 - Accession Number: 12813381; Kohn, Melvin L. 1; Schooler, Carmi 1; Affiliations: 1: National Institute Of Mental Health; Issue Info: Oct69, Vol. 34 Issue 5, p659; Thesaurus Term: OCCUPATIONS; Thesaurus Term: INTERGROUP relations; Subject Term: SOCIAL classes; Subject Term: CLASS relations; Subject Term: EDUCATION; Subject Term: SOCIAL status; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Allen, Gordon
T1 - Eugenics and the Progressives (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1969/10//
VL - 34
IS - 5
M3 - Book Review
SP - 810
EP - 811
SN - 00031224
AB - Reviews the book "Eugenics and the Progressives," by Donald K. Pickens.
KW - EUGENICS
KW - NONFICTION
KW - PICKENS, Donald K.
KW - EUGENICS & the Progressives (Book)
N1 - Accession Number: 12813463; Allen, Gordon 1; Affiliations: 1: National Institute of Mental Health; Issue Info: Oct69, Vol. 34 Issue 5, p810; Subject Term: EUGENICS; Subject Term: NONFICTION; Reviews & Products: EUGENICS & the Progressives (Book); People: PICKENS, Donald K.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
AU - Murphy, D. L.;
AU - Bunney, W. E.;
T1 - Lithium carbonate treatment in depression and mania
CT - Lithium carbonate treatment in depression and mania
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1969/10/01/
VL - 21
IS - Oct
SP - 486
EP - 496
AD - National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-1807; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 40; Journal Coden: ARGPAQ; Section Heading: Investigational Drugs; Abstract Author: Harold N. Godwin
N2 - In a controlled longitudinal study, 12 manic and 18 depressed patients were studied to evaluate lithium carbonate used for both mania or depression. Therapeutic results were obtained in 9 of the 12 mania patients studied. Only 5 of the 18 depressed patients showed complete remission of symptoms while on lithium carbonate. It was concluded that lithium carbonate should not be considered an antidepressant but further investigation should be conducted.
KW - Lithium carbonate--depression and mania-;
KW - Psychotherapeutic agents--lithium carbonate;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haskell, C. M.;
AU - Canellos, G. P.;
T1 - (-)-Asparaginase resistance in human leukemia--asparagine synthetase
CT - (-)-Asparaginase resistance in human leukemia--asparagine synthetase
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1969/10/01/
VL - 18
IS - Oct
SP - 2578
EP - 2580
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-0463; Language: English; Chemical Name: Asparagine--7006-34-0 Asparaginase--9015-68-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 13; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: A. Leon Moore
N2 - This is a study of asparagine synthetase levels in 18 patients with leukemia who were subsequently treated with (-)-asparaginase, 200 I.U./kg., in order to determine whether this enzyme may play a role in human leukemic cell resistance to (-)-asparaginase. The level of asparagine synthetase in leukemic cells was nearly undetectable prior to therapy regardless of subsequent response to (-)-asparaginase treatment. The 4 patients in whom an antileukemic effect occurred had no change in asparagine synthetase with therapy; however, there was a sevenfold increase in the mean level of asparagine synthetase in the 5 patients who were unresponsive to treatment. The difference between asparagine synthetase levels in the sensitive and resistant patients, determined during or after (-)-asparaginase, was highly significant. It was concluded from this data that (-)-asparaginase resistance in human leukemic cells is at least in part related to the capacity for (-)-asparagine biosynthesis via asparagine synthetase.
KW - Asparagine--synthetase-;
KW - Asparaginase--effect on asparagine synthetase levels-;
KW - Antineoplastic agents--asparaginase--effect, on asparagine synthetase in leukemia patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Heine, U.;
T1 - Electron microscopic studies on Hela cells exposed to the antibiotic toyocamycin
CT - Electron microscopic studies on Hela cells exposed to the antibiotic toyocamycin
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/10/01/
VL - 29
IS - Oct
SP - 1875
EP - 1880
SN - 00085472
AD - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-0946; Language: English; Chemical Name: Toyocamycin--606-58-6; Therapeutic Class: (8:12); AHFS Class: Antibiotics toyocamycin; References: 28; Journal Coden: CNREA8; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2 - This report describes the changes in cellular ultramorphology induced by various doses of toyocamycin. In low concentrations toyocamycin selectively induces an enlargement of the pars fibrosa in the nucleolus. High concentrations provoke morphologic changes similar to those observed with dactinomycin.
KW - Toyocamycin--morphological effects-;
KW - Antibiotics--toyocamycin--morphological effects on Hela cells;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0946&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-41057-009
AN - 2013-41057-009
AU - Shore, Milton F.
AU - Massimo, Joseph L.
T1 - Five years later: A followup study of comprehensive vocationally oriented psychotherapy.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1969/10//
VL - 39
IS - 5
SP - 769
EP - 773
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-41057-009. PMID: 5348784 Partial author list: First Author & Affiliation: Shore, Milton F.; Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Occupational Guidance; Psychotherapy. Minor Descriptor: Development; Employment Status; Juvenile Delinquency. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 1969.
AB - This is the second in a continuing series of followup studies of adolescent delinquent boys successfully treated in an experimental program five years ago. Few legal difficulties, stable employment, and personal growth were shown in those treated. On the other hand, three of the untreated youth were in adult correctional institutions, employment was irregular, personal rewards few. Contact with usual rehabilitative agents of society seemed unable to reverse the deterioration in the untreated group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent delinquency
KW - stable employment
KW - personal growth
KW - vocational psychotherapy
KW - 1969
KW - Occupational Guidance
KW - Psychotherapy
KW - Development
KW - Employment Status
KW - Juvenile Delinquency
KW - 1969
DO - 10.1111/j.1939-0025.1969.tb00658.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41057-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41057-011
AN - 2013-41057-011
AU - Jacobson, Gary
AU - Ryder, Robert G.
T1 - Parental loss and some characteristics of the early marriage relationship.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1969/10//
VL - 39
IS - 5
SP - 779
EP - 787
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Jacobson, Gary, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US, 02114
N1 - Accession Number: 2013-41057-011. PMID: 5348786 Partial author list: First Author & Affiliation: Jacobson, Gary; Family Development Section, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Interpersonal Interaction; Marriage; Parental Death; Trust (Social Behavior). Minor Descriptor: Pathology. Classification: Group & Interpersonal Processes (3020). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 1969.
AB - People who had experienced the final disruption of a previous fundamental relationship through the death of a parent were studied in the first few years of their marriage. The results contribute to the understanding not only of pathological issues in marriage such as the inability to maintain trust or resolve anger but also of nonpathological issues such as interpersonal closeness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental loss
KW - marriage relationship
KW - pathological issues
KW - interpersonal closeness
KW - trust
KW - 1969
KW - Interpersonal Interaction
KW - Marriage
KW - Parental Death
KW - Trust (Social Behavior)
KW - Pathology
KW - 1969
DO - 10.1111/j.1939-0025.1969.tb00660.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41057-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Gallelli, J. F.;
AU - MacLowry, J. D.;
AU - Skolaut, M. W.;
T1 - Stability of antibiotics in parenteral solutions
CT - Stability of antibiotics in parenteral solutions
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1969/11/01/
VL - 26
IS - Nov
SP - 630
EP - 635
SN - 00029289
AD - Pharmacy Department, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0933; Language: English; Chemical Name: Ampicillin--69-53-4 Carbenicillin--4697-36-3 Cephaloridine--50-59-9 Chloramphenicol--56-75-7 Erythromycin--114-07-8 Gentamicin--1403-66-3 Kanamycin--59-01-8 Methicillin--61-32-5 Nafcillin--147-52-4 Oleandomycin--3922-90-5 Penicillin G--61-33-6 Tetracycline--60-54-8 Vancomycin--1404-90-6 Cephalothin--153-61-7 Lincomycin--154-21-2; References: 2; Journal Coden: AJHPA9; Section Heading: Drug Stability; Microbiology
N2 - Stability studies involving 16 antibiotics used in parenteral solutions were conducted to determine their antimicrobial potency and duration of activity after preparation. The drugs used in the studies were ampicillin sodium, carbenicillin disodium, cephaloridine, cephalothin sodium, chloramphenicol, colistimethate sodium, erythromycin lactobionate, gentamicin sulfate, kanamycin sulfate, lincomycin hydrochloride, methicillin sodium, nafcillin sodium, oleandomycin phosphate, penicillin G potassium buffered, tetracycline hydrochloride and vancomycin hydrochloride. All studies were conducted at 25DG C. and 5DG C. Sample solutions were assayed microbiologically, visually inspected and the pH recorded over a period of 2 months. All antibiotics except ampicillin sodium retained their initial antimicrobial activity for a minimum of one month at 5DGC. in both normal saline and dextrose 5% in water. The antimicrobial activity of 5 antibiotics (ampicillin sodium, cephalothin sodium, nafcillin sodium, penicillin G potassium buffered and tetracycline hydrochloride) at 25DG C. varied considerably depending upon which vehicle was used. With the exception of methicillin sodium solutions, it was impossible to correlate change in pH with decrease in activity of the sample solutions. Although physical changes were observed in 7 antibiotics studied--ampicillin sodium, cephaloridine, cephalothin sodium, chloramphenicol, nafcillin sodium, tetracycline hydrochloride and vancomycin hydrochloride--all except the dextrose solutions of ampicillin showed no decrease in activity at 5DG C. up to 60 days.
KW - Ampicillin--sodium-;
KW - Carbenicillin--disodium-;
KW - Cephaloridine--stability-;
KW - Chloramphenicol--stability-;
KW - Erythromycin--lactobionate-;
KW - Gentamicin--sulfate-;
KW - Kanamycin--sulfate-;
KW - Methicillin--sodium-;
KW - Nafcillin--sodium-;
KW - Oleandomycin--phosphate-;
KW - Penicillin G--potassium-;
KW - Tetracycline--hydrochloride-;
KW - Vancomycin--hydrochloride-;
KW - Cephalothin--sodium-;
KW - Colistimethate--sodium-;
KW - Lincomycin--hydrochloride-;
KW - Injections--antibiotics--stability, parenteral solutions;
KW - Antibiotics--stability--parenteral solutions;
KW - Stability--antibiotics--parenteral solutions;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0933&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lewis, J. L., Jr.;
AU - Davis, R. C.;
AU - Parker, J. T.;
T1 - Modification of the immunologic response to human choriocarcinoma in the hamster cheek pouch by heterologous antilymphocyte serum
CT - Modification of the immunologic response to human choriocarcinoma in the hamster cheek pouch by heterologous antilymphocyte serum
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/11/01/
VL - 29
IS - Nov
SP - 1988
EP - 1994
SN - 00085472
AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-1684; Language: English; Chemical Name: Methotrexate--59-05-2 Antilymphocyte serum--0; References: 25; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2 - This article compares the response to methotrexate of tumors growing in the pouch of antilymphocyte serum-treated hamsters with that in control animals not undergoing immunosuppression. Methotrexate had less antineoplastic effect on choriocarcinoma in antilymphocyte serum-treated hamsters than in the untreated.
KW - Methotrexate--antineoplastic effect-;
KW - Antilymphocyte serum--treated hamsters-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1684&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Liegler, D. G.;
AU - Henderson, E. S.;
AU - Hahn, M. A.;
AU - Oliverio, V. T.;
T1 - Effect of organic acids on renal clearance of methotrexate in man
CT - Effect of organic acids on renal clearance of methotrexate in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1969/11/01/
VL - 10
IS - Nov-Dec
SP - 849
EP - 857
SN - 00099236
AD - Laboratory of Chemical Pharmacology and Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-2146; Language: English; Chemical Name: Methotrexate--59-05-2; References: 25; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2 - The renal clearance of methotrexate was compared with that of inulin and para-aminohippurate in 15 patients with disseminated malignancy. The clearance of methotrexate exceeded that of inulin clearance in all cases, indicating methotrexate is not only filtered but is also actively secreted by the renal tubules. The simultaneous intravenous administration of weak organic acids resulted, generally, in suppressive effects on the clearance of methotrexate. Salicylate and high concentrations of para-aminohippurate reduced methotrexate clearance well below the glomerular filtration rate; whereas, sulfisoxazole had only a minimal effect on total methotrexate clearance. The variations of plasma protein binding of methotrexate induced by these same drugs did not correlate with the direction or degree of methotrexate clearance. It is concluded from these studies that methotrexate is excreted by a combination of glomerular filtration and active tubular transport and that methotrexate clearance is not directly related to the level of free methotrexate presented to the kidneys. It is furthermore suggested that the alterations in plasma protein binding and renal clearance of methotrexate provoked by the simultaneous administration of other organic acids may be clinically exploitable in cancer chemotherapy.
KW - Methotrexate--excretion-;
KW - Acids--organic--effects, on renal clearance of methotrexate;
KW - Excretion--methotrexate--renal clearance, effect of organic acids;
KW - Metabolism--methotrexate--renal clearance, effect of organic acids;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2146&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gordon, J. B.;
T1 - Politics of community Medicine projects
CT - Politics of community Medicine projects
JO - Medical Care (USA)
JF - Medical Care (USA)
Y1 - 1969/11/01/
VL - 7
IS - Nov-Dec
SP - 419
EP - 428
SN - 00257079
AD - Public Health Service, National Institutes of Health, Room 2A32, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 7-3327; Language: English; References: 32; Journal Coden: MDLCBD; Section Heading: Sociology, Economics and Ethics
N2 - The community health center is a new institution which has been promoted by the Office of Economic Opportunity to provide health service to the poor, to establish an alternate model for medical practice, and to help reintegrate the poor into the mainstream of society. Among the barriers to the success of this innovation has been a lack of political realism on the part of many of the participants. A sociological analysis of the process of project evolution demonstrating the many opportunities for controversy and conflict to develop, is presented. Inferences from conflict theory are presented to show how a sophisticated approach to controversy can expedite social change. If health professionals, including pharmacists, are to be involved in the wide range of social and physical ills of their patients they must be familiar with these strategies.
KW - Sociology--health care--centers, community participants lack political realism;
KW - Pharmacists--health care--centers, community need for political realism if center to succeed;
KW - Health care--centers--community, success dependent upon political realism by participants;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3327&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tjio, J.-H.;
AU - Pahnke, W. N.;
AU - Kurland, A. A.;
T1 - LSD and chromosomes. A controlled experiment
CT - LSD and chromosomes. A controlled experiment
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1969/11/03/
VL - 210
IS - Nov 3
SP - 849
EP - 856
AD - National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland 20014
AD - reprints: Maryland Psychiatric Research Center, Box 3235, Baltimore, Maryland 21228
N1 - Accession Number: 7-1404; Language: English; Trade Name: LSD; Generic Name: Lysergic acid diethylamide; References: 27; Journal Coden: JAMAAP; Section Heading: Pharmacology
N2 - The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD). Double-blind, controlled research of the effects of the drug in psychotherapy and in 5 black market LSD users who volunteered to take pure LSD in a research setting is reported. Statistical analysis revealed no significant difference between the before- and after-LSD chromosomal aberration rates. In addition, a post-LSD study of 8 normal subjects who had received LSD in previous research experiments was also performed with the same cytogenetic methods. The results of these experiments consistently supported the conclusion that at this time there is no definite evidence that pure LSD damages chromosomes of human lymphocytes in vivo as studied from 72-hour cultures.
KW - Lysergic acid diethylamide--toxicity studies-;
KW - Toxicity studies--lysergic acid diethylamide--conclusion of no definite evidence of damage to chromosomes of human lymphocytes in vivo;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1404&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haskell, C. M.;
AU - Canellos, G. P.;
AU - Leventhal, B. G.;
AU - Carbone, P. P.;
AU - Block, J. B.;
AU - et al;
T1 - L-Asparaginase: therapeutic and toxic effects in patients with neoplastic disease
CT - L-Asparaginase: therapeutic and toxic effects in patients with neoplastic disease
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1969/11/06/
VL - 281
IS - Nov 6
SP - 1028
EP - 1034
SN - 00284793
AD - reprints: National Cancer Institute, Bldg. 10/12-N-226, Bethesda, Maryland 20014
N1 - Accession Number: 7-3393; Language: English; Trade Name: NSC-109229; Generic Name: Asparaginase; Chemical Name: Asparaginase--9015-68-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 38; Journal Coden: NEJMAG; Section Heading: Investigational Drugs; Pharmacology
N2 - Escherichia coli L-asparaginase (NSC-109229) was administered to 55 patients; two thirds of the patients received 200 I.U./kg./day but others received doses ranging from 50 to 2000 I.U./kg./day. Responses were restricted to a patient with melanoma, 4 patients with lymphoma and 11 patients with leukemia. The complete remission rate was 26% in patients with acute lymphatic leukemia, with a median remission duration of 9 weeks. Most patients tolerated L-asparaginase; however, severe toxicity appeared in a variety of forms. Hypersensitivity occurred in 14 of the patients. Depression of clotting factors occurred in 16 of 20 evaluable patients, liver dysfunction in 33 of 35 evaluable patients, central nervous system disturbances in 18 of 35 evaluable adults (but none of the children), pancreatitis in 6 patients, and renal failure in 2 patients.
KW - Asparaginase--toxicity studies-;
KW - Toxicity studies--asparaginase--in patients with neoplastic diseases;
KW - Antineoplastic agents--asparaginase--toxicity studies;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3393&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Epstein, E. H., Jr.;
AU - Lutzner, M. A.;
T1 - Folliculitis induced by actinomycin D
CT - Folliculitis induced by actinomycin D
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1969/11/13/
VL - 281
IS - Nov 13
SP - 1094
EP - 1096
SN - 00284793
AD - reprints: Building 10, Room 12N238, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3372; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dactinomycin; References: 11; Journal Coden: NEJMAG; Section Heading: Toxicity
N2 - In 9 of 11 adult patients treated with actinomycin D (dactinomycin) a characteristic skin eruption developed, with predictable progression from erythema to papules and pustules and from face to trunk. The dominant histologic feature of these lesions was initial replacement of the hair follicles and sebaceous glands with neutrophils. After resolution of the inflammation, plugged, dilated follicles persisted for several months. Although often dramatic and unsightly, this eruption was benign and required no modification of treatment.
KW - Dactinomycin--toxicity-;
KW - Toxicity--dactinomycin--folliculitis;
KW - Antineoplastic agents--dactinomycin--toxicity, folliculitis;
KW - Drugs, adverse reactions--dactinomycin--folliculitis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3372&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zaharko, D. S.;
AU - Bruckner, H.;
AU - Oliverio, V. T.;
T1 - Antibiotics alter methotrexate metabolism and excretion
CT - Antibiotics alter methotrexate metabolism and excretion
JO - Science
JF - Science
Y1 - 1969/11/14/
VL - 166
IS - Nov 14
SP - 887
EP - 888
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-3666; Language: English; Chemical Name: Sulfathiazole--72-14-0 Methotrexate--59-05-2 Neomycin--1404-04-2; References: 10; Journal Coden: SCIEAS; Section Heading: Drug Interactions
N2 - Methotrexate is metabolized by the intestinal flora of normal mice. This metabolism in normal mice is reduced by treatment with neomycin and sulfathiazole. The same is true in germ-free mice. In addition to affecting metabolism, neomycin and sulfathiazole alter physiological distribution of methotrexate so that excretion by the intestinal route is significantly enhanced.
KW - Sulfathiazole--and neomycin-;
KW - Methotrexate--metabolism-;
KW - Neomycin--and sulfathiazole-;
KW - Drug interactions--methotrexate--metabolism and excretion altered by neomycin and sulfathiazole, in mice;
KW - Metabolism--methotrexate--reduction, by neomycin and sulfathiazole, in mice;
KW - Drugs, body distribution--methotrexate--altered by neomycin and sulfathiazole;
KW - Excretion--methotrexate--intestinal, enhanced by neomycin and sulfathiazole;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3666&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levine, P. H.;
AU - Hamstra, R. D.;
T1 - Megaloblastic anemia of pregnancy simulating acute leukemia
CT - Megaloblastic anemia of pregnancy simulating acute leukemia
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1969/12/01/
VL - 71
IS - Dec
SP - 1141
EP - 1147
SN - 00034819
AD - Viral Leukemia and Lymphoma Branch, Bldg. 37, Rm 1-A-15, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-2782; Language: English; Chemical Name: Iron--7439-89-6; References: 16; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - Two patients had megaloblastic anemia of pregnancy, presenting with histories and bone marrow smears compatible with acute granulocytic leukemia. A review of the reported cases of acute leukemia in pregnancy indicates the difficulty in making a definite diagnosis on the basis of clinical history and smears of the blood and bone marrow. The role of concurrent iron deficiency in obscuring the diagnosis of megaloblastic anemia is suggested. A brief trial of folic acid and vitamin B12 (cyanocobalamin) is indicated in all patients with equivocal marrow findings or the possibility of vitamin deficiency.
KW - Iron--deficiency-;
KW - Anemias--megaloblastic--of pregnancy, simulating acute leukemia;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2782&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ryan, J. J.;
AU - Ketcham, A. S.;
AU - Wexler, H.;
T1 - Warfarin therapy as an adjunct to the surgical treatment of malignant tumors in mice
CT - Warfarin therapy as an adjunct to the surgical treatment of malignant tumors in mice
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2191
EP - 2194
SN - 00085472
AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-2987; Language: English; Chemical Name: Warfarin--81-81-2; References: 21; Journal Coden: CNREA8; Section Heading: Pharmacology; Drug Evaluations
N2 - This study is an assessment of warfarin anticoagulation as an adjunct to the surgical removal of malignant tumors in mice. Warfarin anticoagulation throughout the pre-, intra-, and early postoperative periods significantly improved the long-term survival and the cure rate of mice following amputation of a tumor bearing limb. The level of anticoagulation producing this effect was not excessive, with the prothrombin time prolonged between 2.8 and 3.5 times the normal, average value. Deaths from complications were increased in the warfarin-treated mice, but not nearly to the extent that deaths with metastatic disease were reduced. The mechanism by which warfarin influences primary tumor growth and metastatic spread is not clear. Hopefully, anticoagulation may be of practical value in the treatment of malignant disease in humans.
KW - Warfarin--anticoagulation-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2987&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Henderson, E. S.;
AU - Samaha, R. J.;
T1 - Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies
CT - Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2272
EP - 2280
SN - 00085472
AD - Leukemia Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3458; Language: English; References: 54; Journal Coden: CNREA8; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Jimmie L. Hall
N2 - This paper discusses the following question: Is combination chemotherapy superior to single drug therapy in the treatment of cancer? In general, combination therapy is indicated only if the disease does not regularly respond to any single form of treatment, but can be modified by 2 or more agents. A number of published studies which compare combination with single drug therapy are reviewed.
KW - Drugs--combined therapy--cancer, comparison with single drug therapy;
KW - Antineoplastic agents--cancer--combined vs. single drug therapy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3458&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zubrod, C. G.;
T1 - Summary of informal discussion on clinical cancer chemotherapy today
CT - Summary of informal discussion on clinical cancer chemotherapy today
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2284
SN - 00085472
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-2997; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW - Cancer--chemotherapy--clinical, summary of informal discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2997&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Goldin, A.;
T1 - Factors pertaining to complete drug-induced remission of tumors in animals and man
CT - Factors pertaining to complete drug-induced remission of tumors in animals and man
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2285
EP - 2291
SN - 00085472
AD - Cancer Chemotherapy National Service Center, Chemotherapy, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-3457; Language: English; References: 41; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - This article discusses factors that prevent an antineoplastic agent from inducing a complete remission. A complete remission involves the elimination or the control of growth of the tumor cell population, and is subject to a balance of factors pertaining to drug, tumor, and host. The major limiting factor in antineoplastic therapy is the toxicity of the drug to the host. Other factors which may influence the attainment of complete remission are the extent of action of the drug on the tumor cells, the degree of challenge represented by the number of tumor cells, the origin and extent of tumor cell resistance, the degree of sequestration of the tumor cells, and the pharmacologic and immunologic status of the host.
KW - Antineoplastic agents--remission of tumors--factors preventing;
KW - Toxicity--antineoplastic agents;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3457&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Perry, S.;
T1 - Reduction of toxicity in cancer chemotherapy
CT - Reduction of toxicity in cancer chemotherapy
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2319
EP - 2325
SN - 00085472
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-2479; Language: English; References: 57; Journal Coden: CNREA8; Section Heading: Toxicity; Pharmacology; Abstract Author: Jimmie L. Hall
N2 - This paper reviews the current status of the supportive care of patients undergoing treatment with the antineoplastic agents. The most serious complications of cancer chemotherapy are the thrombocytopenia and leukopenia caused by bone marrow depression. Platelet replacement by transfusion is now generally recognized to be valuable in preventing or controlling the hemorrhage due to thrombocytopenia. Leukocyte replacement, however, is not yet a practical procedure, and leukopenia often allows bacterial or fungal infections to overwhelm the patient. Antibiotics are of limited value in this situation. Patient isolation and protection, as by laminar air flow rooms, are one means of reducing this infection hazard. Toxicity to the bone marrow or to the gastrointestinal tract may preclude administration of the antineoplastic drug in doses adequate to obtain optimum tumor cell kill. Other complications of antineoplastic agents include nausea, vomiting, diarrhea, constipation, chemical cystitis, muscle weakness, hepatotoxicity, alopecia, peripheral neuropathy, and urate neuropathy.
KW - Antineoplastic agents--toxicity--in cancer chemotherapy, reduction;
KW - Toxicity--antineoplastic agents--in cancer chemotherapy, reduction;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2479&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rall, D. P.;
T1 - Summary of informal discussion on the design of more selective antitumor agents
CT - Summary of informal discussion on the design of more selective antitumor agents
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2407
SN - 00085472
AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3237; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW - Antineoplastic agents--development--design of more selective agents;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3237&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lipsett, M. B.;
T1 - Prospects in endocrinology for chemotherapy
CT - Prospects in endocrinology for chemotherapy
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2408
EP - 2411
SN - 00085472
AD - Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-3238; Language: English; Journal Coden: CNREA8; Section Heading: Pharmacology
KW - Chemotherapy--prospects in endocrinology;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3238&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rall, D. P.;
T1 - New approaches in administration of anticancer drugs
CT - New approaches in administration of anticancer drugs
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1969/12/01/
VL - 29
IS - Dec
SP - 2471
EP - 2474
SN - 00085472
AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-2786; Language: English; References: 5; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - This paper analyzes some of the factors which appear to be important in the successful chemotherapy of certain tumors and applies these factors to the important tumors thus far resistant to chemotherapy.
KW - Antineoplastic agents--administration--new approaches;
KW - Drug administration--antineoplastic agents--new approaches;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2786&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2009-11544-003
AN - 2009-11544-003
AU - Yolles, Stanley F.
T1 - Foreword.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1969///Win 1969
VL - 1
IS - 1
SP - 3
EP - 3
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11544-003. Partial author list: First Author & Affiliation: Yolles, Stanley F.; National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Information Dissemination; Printed Communications Media; Schizophrenia; Scientific Communication. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 1. Issue Publication Date: Win 1969.
AB - Schizophrenia is the most prevalent and incapacitating of the major mental illnesses. For the past two decades the National Institute of Mental Health has supported a broad program of research and training directed toward the understanding and control of this complex disorder. The Schizophrenia Bulletin is one manifestation of the Institute's concern with the need to stimulate interest in the problems posed by schizophrenia. By providing a broad overview of schizophrenia the Bulletin will further the evolution of a coordinated approach to this recalcitrant disorder. The Bulletin will also help facilitate the interchange and dissemination of information in this active field. It is designed therefore to serve a wide audience of lay and professional persons who are concerned with the vast, and often perplexing, issues presented by schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Schizophrenia Bulletin
KW - schizophrenia research
KW - information exchange & dissemination
KW - 1969
KW - Information Dissemination
KW - Printed Communications Media
KW - Schizophrenia
KW - Scientific Communication
KW - 1969
DO - 10.1093/schbul/1.1.3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11544-001
AN - 2009-11544-001
AU - Rosenthal, David
T1 - Problems of sampling and diagnosis in the major twin studies of schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1969///Win 1969
VL - 1
IS - 1
SP - 11
EP - 26
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11544-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, Division of Clinical, Behavioral, and Biological Research, Intramural Research Program, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article; Reprint. Language: English. Major Descriptor: Experimentation; Genetics; Schizophrenia; Twins. Minor Descriptor: Diagnosis; Sampling (Experimental). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: Win 1969.
AB - This reprinted article originally appeared in the Journal of Psychiatric Research, Vol 1(2), 1962, 116-134. (The following abstract of the original article appeared in record [rid]1964-09069-001[/rid].) Problems of sampling and diagnosis in the 5 major twin studies of schizophrenia are critically reviewed. The main pitfalls and inconsistencies between the studies are indicated, and recommendations are made regarding methods of handling these problems. It is pointed out that despite their difficulties and errors, the twin studies probably have contributed our most reliable data regarding the inheritance of schizophrenia. On the basis of this review, one could conclude that the proportion of the variance contributed by heredity with respect to those disorders called schizophrenic is probably less than some have alleged, and that we may only now be at the point of being able to expand our knowledge of these matters in a heuristically important way. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - twins
KW - schizophrenia studies
KW - sampling & diagnosis problems
KW - psychoses
KW - 1969
KW - Experimentation
KW - Genetics
KW - Schizophrenia
KW - Twins
KW - Diagnosis
KW - Sampling (Experimental)
KW - 1969
DO - 10.1093/schbul/1.1.11
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11544-005
AN - 2009-11544-005
AU - Pollin, William
AU - Stabenau, James R.
AU - Allen, Martin G.
T1 - Schizophrenia and adult stature: The absence of a relationship in a sample of 16,000 pairs of male twins.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1969///Win 1969
VL - 1
IS - 1
SP - 40
EP - 41
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11544-005. Partial author list: First Author & Affiliation: Pollin, William; Section on Twin and Sibling Studies, Adult Psychiatry Branch, Clinical Investigations, Intramural Research Program, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Body Size; Body Weight; Monozygotic Twins; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 2. Issue Publication Date: Win 1969.
AB - Several recent studies have reported a relationship between low birth weight and the appearance of schizophrenia in studies of identical twins, and same-sexed siblings discordant for schizophrenia. Possible psychodynamic and biologic mechanisms, which might account for this relationship, have been suggested. Other investigators, however, working with different samples, have reported negative findings with respect to such a birth weight/schizophrenia relationship. In view of these discrepant results, and the paucity of reports dealing with possible relationships between adult size and weight on the one hand, and schizophrenia on the other, we examined the data available in the National Research Council's Veteran Twin Registry concerning this relationship. There was no significant difference between the mean height or weight of the group of index twins (those who developed schizophrenia) as compared to their non-schizophrenic cotwin controls. Similarly there was no significant difference between the number of pairs in which the index twin was the lighter or shorter at the time of induction as compared to his non-schizophrenic cotwin control. These data indicate that no simple relationship exists between adult stature and the development of schizophrenia, in this sample of monozygotic twins. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - male monozygotic twins
KW - body size
KW - body weight
KW - adult stature
KW - 1969
KW - Body Size
KW - Body Weight
KW - Monozygotic Twins
KW - Schizophrenia
KW - 1969
DO - 10.1093/schbul/1.1.40
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11544-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Bernstein, R. S.;
AU - Robbins, J.;
T1 - Intermittent therapy with L-thyroxine
CT - Intermittent therapy with L-thyroxine
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1969/12/25/
VL - 281
IS - Dec 25
SP - 1444
EP - 1448
SN - 00284793
AD - reprints: Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3405; Language: English; Chemical Name: Thyroxine--7488-70-2; References: 19; Journal Coden: NEJMAG; Section Heading: Drug Evaluations; Pharmacology
N2 - Two athyreotic patients and 5 patients on suppressive doses of L-thyroxine (L-T4) were studied with intermittent oral therapy given as a single weekly dose. Thyroid tests were compared during intermittent therapy of 2.0 mg. weekly and during daily therapy with 0.3 mg. of L-T4. Serum thyroxine levels were significantly lower on intermittent therapy in 3 of 7 patients. Nevertheless, 5 of 5 patients showed complete suppression of 131I uptake by the thyroid gland one week after the dose of thyroxine. All patients were clinically euthyroid, and there was no difference in serum cholesterol. There were no toxic symptoms even after a single oral dose of 2.5 mg. of L-T4. Intermittent therapy proved to be an effective means of thyroid replacement.
KW - Thyroxine--levo--;
KW - Dosage--thyroxine--levo-, intermittent oral therapy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3405&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lucas, G.;
AU - Lehrnbecher, W.;
T1 - Hydroxyurea in nasopharyngeal cancer
CT - Hydroxyurea in nasopharyngeal cancer
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1969/12/29/
VL - 210
IS - Dec 29
SP - 2397
AD - National Institute of Mental Health, Washington, D. C.
N1 - Accession Number: 7-3859; Language: English; Chemical Name: Hydroxyurea--127-07-1; References: 3; Journal Coden: JAMAAP; Section Heading: Drug Evaluations; Abstract Author: Dale E. Johnson
N2 - The concomitant use of hydroxyurea and irradiation in nasopharyngeal cancer in one patient is reported.
KW - Hydroxyurea--and irridiation-;
KW - Irradiation--and hydroxyurea--concomitant use in nasopharyngeal cancer;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3859&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Wilcox, Michael
T1 - υ-Glutamyl Phosphate Attached to Glutamine-Specific tRNA.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1969/12/31/
VL - 11
IS - 3
M3 - Article
SP - 405
EP - 412
SN - 00142956
AB - B. subtilis Gln-tRNA formation, in vitro, involves the initial acceptance of glutamic acid by tRNAGln to form a missense Glu-tRNGln intermediate which is converted to Gln-tRNA by a subsequent amidation step, catalyzed by a specific amido-transferase, and requiring divalent cations, ATP, and L-glutamine or L-asparagine as amide donor. This reaction is associated with stoichiometric cleavage of glutamine and ATP to yield glutamic acid and Pi, respectively. Amidation proceeds via the formation of an activated intermediate which is shown to be γ-phospho-Glu-tRNAGln (P-γ-Glu-tRNAGln). P-γ-Glu-tRNAGln, bound to amido-transfcrase, is detected following incubation in the absence of amide donor. Subsequent addition of L-glutamine to the system leads to the rapid toss of the phosphate moiety from the intermediate concomitantly with the formation of Gln-tRNA, which is released from the enzyme. Consequences of the pathway, if it is duplicated in vivo, are the separation of the synthesis of glutamine destined for protein from that of free glutamine and, further, the coupling of the synthesis of the ammo acid with that, of protein. These implications are discussed with regard to their bearing on possible functions of the pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTAMYL-tRNA synthetase
KW - GLUTAMIC acid
KW - TRANSFER RNA
KW - ADENOSINE triphosphate
KW - TRANSFERASES
KW - AMIDES
KW - CATIONS
N1 - Accession Number: 13441939; Wilcox, Michael 1; Source Information: 1969, Vol. 11 Issue 3, p405; Subject: GLUTAMYL-tRNA synthetase; Subject: GLUTAMIC acid; Subject: TRANSFER RNA; Subject: ADENOSINE triphosphate; Subject: TRANSFERASES; Subject: AMIDES; Subject: CATIONS; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=13441939&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - Gen
ID - 9999-42358-000
AN - 9999-42358-000
AU - Derogatis, Leonard R.
AU - Lipman, Ronald S.
AU - Covi, Lino
AU - Rickels, Karl
AU - Uhlenhuth, E. H.
T1 - Symptom Distress Checklist-31
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1970///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-42358-000. Acronyms: SCL. Partial author list: First Author & Affiliation: Derogatis, Leonard R.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. Release Date: 20150907. Correction Date: 20151207. Instrument Type: Checklist. Test Location: Table 1, Page 166. Test Format: This 31-item measure utilizes a 4-point scale of discomfort from 'not at all' to 'extremely' with a 'not elicited' option.. Language: English. Constructs: Psychopathology; Symptom Distress; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300).
AB - Purpose: The purpose of the Symptom Distress Checklist-31 is to assess distress caused by symptoms of psychopathology.
AB - Description: The Symptom Distress Checklist-31 (SCL; Derogatis et al., 1970) was developed to assess symptoms of psychopathology. The 31 items for this measure were taken from the item pool of the Symptom Distress Checklist, initially developed by Parloff, Kellman, and Frank (1954), and further amplified by Frank et al. (1957). All items are rated on a 4-point scale of discomfort from 'not at all' to 'extremely'. Although the SCL was originally developed as a patient self-rating instrument, doctors' ratings of the patients on the SCL scales may also be obtained. Doctors were instructed not to infer the presence of symptoms unless they were specifically referred to by the patient, thus, a fifth category 'not elicited' was added to the scales. Clinicians independently categorized the original 64 items of the scale into four a priori clusters: Anxiety, Depression, Anger-Hostility, and Obsessive-Compulsive-Phobic. Those items which were consistently assigned to a particular cluster by at least 70% of the raters at two sessions were retained. Thirty-one items met this criterion. The results of a Varimax rotation of a principal components matrix confirmed the 4-factor model. Using psychiatrists' ratings of anxious neurotic outpatients, analysis indicated an extremely high coincidence between the clinical clusters and the factors resulting from a Procrustes transformation on the original principal component factors, implying that the dimensions isolated here possess substantial reliability. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Anger-Hostility Factor
KW - Anxiety Factor
KW - Depression Factor
KW - Factor Analysis
KW - Obsessive-Compulsive-Phobic Factor
KW - Symptom Distress Checklist-31
KW - Test Development
KW - Test Reliability
U5 - Symptom Distress Checklist-31 (SCL) [Test Development]Dimensions of outpatient neurotic pathology: Comparison of a clinical versus an empirical assessment. (AN: 1970-10813-001 from PsycINFO) Derogatis, Leonard R.; Lipman, Ronald S.; Covi, Lino; Rickels, Karl; Uhlenhuth, E. H.; Apr, 1970. Source: Journal of Consulting and Clinical Psychology. 34(2), American Psychological Association, US; Apr, 1970; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Location: United States; Sample: Anxious Neurotic Outpatients Keywords: Anger-Hostility Factor; Anxiety Factor; Depression Factor; Factor Analysis; Obsessive-Compulsive-Phobic Factor; Symptom Distress Checklist-31; Test Development; Test Reliability; Subjects: Anger; Anxiety; Checklist (Testing); Distress; Factor Structure; Hostility; Major Depression; Obsessive Compulsive Disorder; Phobias; Psychological Assessment; Psychopathology; Symptom Checklists; Test Construction; Test Forms; Test Reliability;
DO - 10.1037/t42358-000
L3 - Full; Full text; 999942358_full_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-42358-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
TY - GEN
AU - Herman, L. G.;
T1 - Critical evaluation of microbiological hazards associated with the pharmacy and the hospital
CT - Critical evaluation of microbiological hazards associated with the pharmacy and the hospital
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1970/01/01/
VL - 27
IS - Jan
SP - 56
EP - 60
SN - 00029289
AD - Environmental Services Branch, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-0788; Language: English; References: 11; Journal Coden: AJHPA9; Section Heading: Environmental Toxicity; Institutional Pharmacy Practice
N2 - Discussed are the human body of patients and hospital staff and such areas and systems of the hospital as the laundry, central sterile supply, water supply, air supply, pharmacy, dietary and tools and instruments as potential microbiological hazards in the hospital. The hospital pharmacist can play an important role in identifying and eliminating microbiological problems, particularly in hospitals without a full-time sanitarian or environmental microbiologist. In large institutions with trained personnel, the pharmacist can still do his part to provide a safer hospital and pharmacy environment.
KW - Hospitals--microbiological hazards--evaluation;
KW - Toxicity, environmental--microbiological hazards--associated with the pharmacy and the hospital, evaluation;
KW - Pharmacy, institutional, hospital--microbiological hazards--evaluation;
KW - Microbiology--hazards--associated with the pharmacy and the hospital, evaluation;
KW - Pharmacists, hospital--can play role in identifying and eliminating microbiological problems;
KW - Environment--hospitals--microbiological hazards, evaluation;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0788&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Willerson, J. T.;
AU - Thompson, R. H.;
AU - Hookman, P.;
AU - Herdt, J.;
AU - Decker, J. L.;
T1 - Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection
CT - Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/01/01/
VL - 72
IS - Jan
SP - 17
EP - 27
SN - 00034819
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-1110; Language: English; Chemical Name: Reserpine--50-55-5; References: 25; Journal Coden: AIMEAS; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2 - Improvement in superficial blood flow was achieved for periods of 1 day to 6 weeks in 6 of 12 patients with Raynaud's disease or Raynaud's phenomenon who received 600 mcg. of reserpine intra-arterially. In one patient, intravenous reserpine produced an objective heat-loss response that lasted 3 days but was accompanied by dizziness, nausea, vomiting and a 15 mm. Hg drop in blood pressure. Oral reserpine was ineffective in producing either subjective or objective improvement in the 2 patients studied. Abnormal esophageal peristalsis was replaced by normal motility after intra-arterial reserpine in 2 of the 5 patients studied. Whether the improvement in esophageal motility was spontaneous or was related to reserpine treatment is not clear.
KW - Reserpine--Raynaud's disease and phenomenon-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1110&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Baer, L.;
AU - Durell, J.;
AU - Bunney, W. E., Jr.;
AU - Levy, B. S.;
AU - Murphy, D. L.;
AU - et al;
T1 - Sodium balance and distribution in lithium carbonate therapy
CT - Sodium balance and distribution in lithium carbonate therapy
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1970/01/01/
VL - 22
IS - Jan
SP - 40
EP - 44
AD - Laboratory of Clinical Science and Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 7-2577; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 44; Journal Coden: ARGPAQ; Section Heading: Pharmacology
N2 - The effect of lithium carbonate administration on 24 hour exchangeable sodium (NaE), sodium space (Na), extracellular fluid (ECF) volume, and residual sodium (NaR) was studied in 11 patients with affective disorders, primarily manic-depressive disease. Lithium carbonate administration was associated with a significant increase in 24 hour Na space and there was a trend for the ECF volume to increase and the NaR to decrease. Patients who responded clinically to lithium carbonate had a significantly greater increase in 24 hour NaE when compared to the nonresponders. No differences were noted between manic and nonmanic patients.
KW - Lithium carbonate--sodium balance and distribution in therapy-;
KW - Psychotherapeutic agents--lithium carbonate--sodium balance and distribution in therapy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2577&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - May, E. L.;
T1 - United States procedures for screening drugs. Testing for dependence liability in animals and man
CT - United States procedures for screening drugs. Testing for dependence liability in animals and man
JO - Bulletin on Narcotics (USA)
JF - Bulletin on Narcotics (USA)
Y1 - 1970/01/01/
VL - 22
IS - Jan-Mar
SP - 11
EP - 17
SN - 0007523X
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-0344; Language: English; Journal Coden: BNUNA5; Section Heading: Methodology
KW - Dependence--methodology--tests, for liability, in animals and man;
KW - Methodology--dependence--tests, for liability, in animals and man;
KW - Drugs--screening--dependence, liability, tests, in animals and man;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0344&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, W. W.;
AU - Carter, S. K.;
AU - Wilson, S. M.;
AU - Newman, J. W.;
AU - Cornfield, J.;
T1 - Joint lethal effects of actinomycin D and radiation in mice
CT - Joint lethal effects of actinomycin D and radiation in mice
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/01/01/
VL - 30
IS - Jan
SP - 51
EP - 57
SN - 00085472
AD - Laboratory of Physiology and Chemotherapy Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0137; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dactinomycin; References: 27; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2 - These studies were primarily concerned with the effects of sublethal actinomycin D (dactinomycin) or radiation doses in mice as measured by the combined lethality of the 2 treatments separated by an interval of one hour to 4 days. Dactinomycin was administered to mice either before or after exposure to radiation to determine the lethality of the 2 treatments. In mice given dactinomycin and challenged with radiation, the high mortality attributed to the combined therapy decreased while mice given radiation then challenged with dactinomycin showed no evidence of recovery from radiation damage.
KW - Dactinomycin--and radiation-;
KW - Radiation--and dactinomycin--toxicity, in mice;
KW - Toxicity--dactinomycin--and radiation, in mice;
KW - Toxicity--radiation--and dactinomycin, in mice;
KW - Antineoplastic agents--dactinomycin--and radiation, toxicity, in mice;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-0137&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
AU - Davis, R. D.;
AU - Carter, S.;
AU - Newman, J.;
AU - Schein, D. R.;
AU - et al;
T1 - Evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man
CT - Evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/01/01/
VL - 11
IS - Jan-Feb
SP - 3
EP - 0
SN - 00099236
AD - Laboratory of Toxicology, Cancer Therapy Evaluation Branch, and Program Analysis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-2635; Language: English; References: 113; Journal Coden: CLPTAT; Section Heading: Methodology; Pharmacology
N2 - The usefulness of dogs and monkeys in predicting potential qualitative drug toxicity in man was examined retrospectively for 25 anticancer compounds of diverse chemical and functional classification. It was found that the large animal screen served to alert the physician to a significant proportion of the total spectrum of drug effects, which were encountered during the clinical use of a new toxic compound. The dog and monkey correctly predicted bone marrow depression, gastrointestinal disturbance, and hepatotoxicity for each drug producing these effects in the clinic; in the case of renal, cardiovascular, and neuromuscular toxicity, however, the large animal screen failed in each instance to predict one drug that produced these toxicities in man. The correct predictions were accomplished at the expense of a high percentage of false positives, which resulted from the necessity of using severely toxic dose levels in order to demonstrate all potential toxicities inherent in any compound. While organ system toxicity observed during an animal study can never be disregarded, it should be viewed with an understanding of certain limitations of animal toxicologic data. While toxicity may develop in man in an organ system predicted susceptible by an animal, a different specific clinical or chemical parameter may be involved. The adverse reaction may appear in man at a greater or lesser dose level or may follow a different order of appearance in relationship to the total spectrum of qualitative toxicity inherent in the compound. A table of 25 anticancer drugs appears. The NSC numbers, chemical and generic names, chemical classification, mechanism of action, route of administration, dosages, and principal toxic effects are tabulated. Sixteen tables in total appear which discuss pharmacologic parameters produced by these agents.
KW - Antineoplastic agents--toxicity studies--usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
KW - Toxicity studies--antineoplastic agents--usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
KW - Methodology--toxicity studies--antineoplastic agents, usefulness of dogs and monkeys in predicting potential qualitative toxicities in man;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2635&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kannel, William B.
AU - McNamara, Patricia M.
AU - Feinleib, Manning
AU - Dawber, Thomas R.
T1 - The unrecognized myocardial infarction.
JO - Geriatrics
JF - Geriatrics
Y1 - 1970/01//
VL - 25
IS - 1
M3 - Article
SP - 75
EP - 87
SN - 0016867X
N1 - Accession Number: 17536913; Kannel, William B. 1; McNamara, Patricia M. 1; Feinleib, Manning 2; Dawber, Thomas R. 3; Source Information: Jan1970, Vol. 25 Issue 1, p75; Number of Pages: 13p; Illustrations: 9 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 5037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17536913&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Davis, John M
T1 - The transmission of information in psychiatry
JO - In North, Jeanne B., Ed. The Information Conscious Society. Proceedings Of The American Society For Information Science. Volume 7. 33rd Annual Meeting, Philadelphia, October 11-15, 1970. 1970. American Society For Information Science, 1140 Connecticut Ave
JF - In North, Jeanne B., Ed. The Information Conscious Society. Proceedings Of The American Society For Information Science. Volume 7. 33rd Annual Meeting, Philadelphia, October 11-15, 1970. 1970. American Society For Information Science, 1140 Connecticut Ave
Y1 - 1970///
M3 - Book
AB - A content analysis was performed on time samples from the last fifty years of psychiatric journal articles. The number of articles in different categories was recording at various points during this time period, and an increase in the number of publications over this time period was found. Four content areas outside of psychiatry were chosen, containing important advances relevant to psychiatry. In all cases there was a marked time lag between the discovery of these advances outside of pschiatry and the time at which they were first frequently quoted in the psychiatric literature. The dates of publication of references listed in the bibliographies of current journals were studied. The age (when published) of the references were felt to give an index of the flow of information over time or 'metabolism' of information in the various fields. The metabolism of information in psychoanalysis and psychiatry was compared to that in psychology and physics.
N1 - Accession Number: ISTA0600262; Davis, John M 1; Affiliations: 1 : National Institute Of Mental Health, Bethesda, Maryland.; Source Info: 1970; Note: Update Code: 0600; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Jacobson, A. E.;
AU - Mokotoff, M.;
T1 - Azabicyclo chemistry. I. Synthesis of 1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepines. B-norbenzomorphans
CT - Azabicyclo chemistry. I. Synthesis of 1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepines. B-norbenzomorphans
JO - J. Med. Chem.
JF - J. Med. Chem.
Y1 - 1970/01/01/
VL - 13
IS - Jan
SP - 7
EP - 9
AD - Laboratory of Chemistry, National Institutes of Health, Bethesda, Maryland 20014, and Department of Medicinal Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
N1 - Accession Number: 7-0716; Language: English; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics benzazepines; References: 13; Journal Coden: JMCMAR; Section Heading: Pharmaceutical Chemistry; Pharmacology
N2 - 1,5-Methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine and its N-methyl derivative (B-norbenzomorphans) have been synthesized from 5-methoxyindan-1-one-3-acetic acid. Both compounds have analgesic activity, the former, half that of codeine, and the latter was found to be comparable to codeine.
KW - Benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2---synthesis and analgesic activity;
KW - B-Norbenzomorphans--benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-, synthesis and analgesic activity;
KW - Analgesics and antipyretics--benzazepines--1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-, synthesis and analgesic activity;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0716&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Prescott, B.;
AU - Caldes, G.;
T1 - Potential antitumor agents: derivatives of 2-hydrazino-5-nitropyridine
CT - Potential antitumor agents: derivatives of 2-hydrazino-5-nitropyridine
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/01/01/
VL - 59
IS - Jan
SP - 101
EP - 104
SN - 00223549
AD - Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3015; Language: English; Chemical Name: Pyridine--100-86-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents pyridine; References: 9; Journal Coden: JPMSAE; Section Heading: Preliminary Drug Testing
N2 - Fifty-one hydrazones of 2-hydrazino-5-nitropyridine have been synthesized for tolerance in DBA mice and for study as potential antitumor agents against the sarcoma 180, adenocarcinoma 755, and leukemia 1210 mouse tumor systems. Of 4 compounds with activity against the sarcoma 180 tumor, 2 derivatives--p-acetaminobenzaldehyde and p-nitrobenzaldehyde--showed good inhibition and confirmed activity. The salicylaldehyde derivative showed slight activity against the adenocarcinoma 755 tumor. None of the compounds were active in the leukemia 1210 mouse tumor system. The highest tolerated dose of the active compounds in mice by I.P. injection was 2 g./kg. The compounds were thus of low toxicity. An extensive table listing chemical data for all of the synthesized components and listing antitumor activity of 4 compounds are included.
KW - Pyridine--2-hydrazino-5-nitro--;
KW - Hydrazones--of 2-hydrazino-5-nitropyridine--synthesized for antitumor testing;
KW - Antineoplastic agents--pyridine--2-hydrazino-5-, derivatives, hydrazones, synthesized for antitumor testing;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3015&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - CHAP
ID - 2004-15424-004
AN - 2004-15424-004
AU - Spaner, Fred E.
ED - Korten, Frances F.
ED - Cook, Stuart W.
ED - Lacey, John I.
ED - Korten, Frances F., (Ed)
ED - Cook, Stuart W., (Ed)
ED - Lacey, John I., (Ed)
T1 - The psychotherapist as an activist in social change: A proponent.
T2 - Psychology and the problems of society.
Y1 - 1970///
SP - 58
EP - 62
CY - Washington, DC, US
PB - American Psychological Association
N1 - Accession Number: 2004-15424-004. Partial author list: First Author & Affiliation: Spaner, Fred E.; Community Mental Health Center Consultation Section, National Institute of Mental Health, US. Release Date: 20040719. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Conference Information: Annual Meeting of the American Psychological Association, Sep, 1969, Washington, DC, US. Conference Note: Invited Address presented to the Division of Psychotherapy at the aforementioned meeting. Major Descriptor: Activism; Psychotherapists; Social Change. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 5.
AB - This chapter submits that psychotherapy as a vehicle for individual change is not distinct from psychotherapy as a vehicle for social change. The author sees the psychotherapist as having an obligation to influence and promote the change process in society. The author discusses a cultural backdrop of psychotherapy and issues needing study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social change
KW - psychotherapists
KW - activists
KW - 1970
KW - Activism
KW - Psychotherapists
KW - Social Change
KW - 1970
DO - 10.1037/10042-004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15424-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Usdin, E.;
T1 - Absorption, distribution and metabolic fate of psychotropic drugs
CT - Absorption, distribution and metabolic fate of psychotropic drugs
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1970/01/01/
VL - 6
IS - Jan
SP - 4
EP - 5
AD - Psychopharmacology Research Branch, National Institute of Mental Health, 5454 Wisconsin Avenue, Chevy Chase, Maryland 20015
N1 - Accession Number: 9-3433; Language: English; References: 62; Journal Coden: PSYBB9; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2 - The principles of absorption, distribution and metabolic fate of psychotherapeutic agents are reviewed. The advantages and disadvantages of oral and parenteral routes of administration are outlined.
KW - Absorption--drugs--principles, review;
KW - Drugs, body distribution--principles--review;
KW - Metabolism--drugs--principles, review;
KW - Drug administration--routes--oral and parenteral, advantages and disadvantages;
KW - Psychotherapeutic agents--metabolism--absorption, and body distribution, principles, review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-3433&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Johnson, D. E.;
AU - Rodriquez, C. F.;
AU - Usdin, E.;
AU - Manian, A. A.;
AU - Levine, J.;
T1 - Assay of chlorpromazine and some of its metabolites in urine samples
CT - Assay of chlorpromazine and some of its metabolites in urine samples
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1970/01/01/
VL - 6
IS - Jan
SP - 44
EP - 72
AD - Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, 5454 Wisconsin Avenue, Chevy Chase, Maryland 20015
N1 - Accession Number: 9-4029; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 2; Journal Coden: PSYBB9; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The use of extraction and thin layer chromatographic techniques for the analysis of chlorpromazine and its metabolites in human urine are described. The method consists of 4 steps: extraction of chlorpromazine and its metabolites from urine, hydrolysis of conjugated derivatives and extraction of the aglycones, separation of the compounds by TLC, and colorimetric quantitation. A bibliography containing 389 references relating to the assay of phenothiazines and metabolites is included.
KW - Chlorpromazine--analysis-;
KW - Tranquilizers--chlorpromazine--analysis, TLC separation and colorimetry, in human urine;
KW - Metabolism--chlorpromazine--analysis, in human urine, by TLC separation and colorimetry;
KW - Colorimetry--chlorpromazine--following TLC separation, in human urine;
KW - Chromatography, thin layer--chlorpromazine--and colorimetry, in human urine;
KW - Phenothiazines--analysis--bibliography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-4029&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Efron, D. H.;
AU - Manian, A. A.;
AU - Harris, S. R.;
T1 - Simultaneous measurement of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma by radioactive derivative formation
CT - Simultaneous measurement of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma by radioactive derivative formation
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1970/01/01/
VL - 6
IS - Jan
SP - 73
EP - 80
AD - Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Maryland 20015
N1 - Accession Number: 9-4030; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; Journal Coden: PSYBB9; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
KW - Chlorpromazine--analysis-;
KW - Tranquilizers--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, in plasma, by radioactive derivative formations;
KW - Blood levels--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, by radioactive derivative formations;
KW - Metabolism--chlorpromazine--base, sulfoxide and demethylated analogs, analysis, by radioactive formations;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-4030&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Lipkin, Lewis
T1 - Pictorial information
JO - Science 169(3941), 166-167 (1970 July 10). 0 Ref
JF - Science 169(3941), 166-167 (1970 July 10). 0 Ref
Y1 - 1970///
M3 - Book Chapter
AB - A reviewq of: rosenfeld, azriel. Picture processing by computer. 1969. Academic press, new york. X + 198 p. Illus. $11.50.
N1 - Accession Number: ISTA0502626; Lipkin, Lewis 1; Affiliations: 1 : National Institutes Of Health.; Source Info: 1970; Note: Update Code: 0500; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Smith, Margot Wiesinger
T1 - MEASURING ETHNOCENTRISM IN HILO, HAWAII: A SOCIAL DISTANCE SCALE.
JO - Sociology & Social Research
JF - Sociology & Social Research
Y1 - 1970/01//
VL - 54
IS - 2
M3 - Article
SP - 220
EP - 236
SN - 00380393
AB - The Bogardus Social Distance Scale and a personal data sheet administered to students at the University of Hawaii, Hilo Campus, yielded 356 responses - two-thirds of the students. Buddhist rural males of Japanese ancestry were found to express the most prejudices. The Social Distance Scale was not a continuum for the Hilo population. Religious preference was the best index of intensity of prejudice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociology & Social Research is the property of University of Southern California and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHNOCENTRISM
KW - CULTURAL relativism
KW - SOCIAL distance
KW - SOCIAL interaction
KW - PREJUDICES
KW - STUDENTS
KW - Hawaii (Hilo)
N1 - Accession Number: 17476272; Smith, Margot Wiesinger 1; Affiliations: 1 : Project coordinator, National Institute of Child Health and Human Development; Source Info: Jan1970, Vol. 54 Issue 2, p220; Historical Period: 1970; Subject Term: ETHNOCENTRISM; Subject Term: CULTURAL relativism; Subject Term: SOCIAL distance; Subject Term: SOCIAL interaction; Subject Term: PREJUDICES; Subject Term: STUDENTS; Number of Pages: 17p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
ID - 2013-40703-016
AN - 2013-40703-016
AU - Liberman, Robert
T1 - Behavorial approaches to family and couple therapy.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1970/01//
VL - 40
IS - 1
SP - 106
EP - 118
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Liberman, Robert, Saint Elizabeth's Hospital, Washington, DC, US, 20032
N1 - Accession Number: 2013-40703-016. PMID: 5410670 Partial author list: First Author & Affiliation: Liberman, Robert; Division of Special Mental Health Research, National Institute of Mental Health, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Couples Therapy; Family Members; Family Therapy; Therapeutic Processes. Minor Descriptor: Goals. Classification: Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). References Available: Y. Page Count: 13. Issue Publication Date: Jan, 1970.
AB - Behavioral approaches to family therapy specify the problems in concrete and observable terms, empirically applying principles of learning in working toward therapeutic goals. The key to successful family therapy can be found in the changes made in the interpersonal consequences of the family members behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavorial approaches
KW - family therapy
KW - couples therapy
KW - therapeutic goals
KW - family members
KW - 1970
KW - Behavior
KW - Couples Therapy
KW - Family Members
KW - Family Therapy
KW - Therapeutic Processes
KW - Goals
KW - 1970
DO - 10.1111/j.1939-0025.1970.tb00683.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40703-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Walsh, J.;
AU - Purcell, R.;
AU - Morrow, A.;
AU - Chanock, R.;
AU - Schmidt, P.;
T1 - Post-transfusion hepatitis after open-heart operations
CT - Post-transfusion hepatitis after open-heart operations
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1970/01/12/
VL - 211
IS - Jan 12
SP - 261
EP - 265
AD - National Institute of Allergy and Infectious Diseases Bethesda, Maryland
N1 - Accession Number: 7-4474; Language: English; References: 20; Journal Coden: JAMAAP; Section Heading: Toxicity
N2 - The incidence of icteric and anicteric hepatitis was determined prospectively in 110 patients undergoing open-heart operations in which cardiopulmonary bypass was used. Patients were supplied with blood from 2 commercial blood banks (82 patients), or from local volunteer donors (28 patients). Serial determinations of serum transaminase levels were obtained for 6 months following operation. Hepatitis developed in 51% (42) of the recipients of commercial blood, but the disease did not occur in any patient who received blood from volunteer donors. The hepatitis carrier rate for commercial blood donors was 6.3%, but, for volunteer donors, was less than 0.6%. This difference in carrier rates probably reflects differences in the donor populations.
KW - Blood--transfusions--after open-heart operations, post-transfusion hepatitis in patients following transfusion, commercial vs. volunteer donors;
KW - Toxicity--blood--transfusions, after open-heart operations, post-transfusion hepatitis;
KW - Contamination--blood--in patients following transfusion, commercial vs. volunteer donors;
KW - Hepatitis--blood--in patients following transfusion, commercial vs. volunteer donors;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4474&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Deardorff, William L.
AU - Gerber, Paul
AU - Vogler, William R.
T1 - Infectious Mononucleosis in Acute Leukemia with Rising Epstein-Barr Virus Antibody Titers.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/02//
VL - 72
IS - 2
M3 - Article
SP - 235
EP - 240
SN - 00034819
AB - The fourth reported case of infectious mononucleosis with onset during the course of acute leukemia and the first patient with myeloblastic leukemia in which titers to EpsteinBarr (EB) virus were found coincident with the appearance of heterophil antibodies are presented. No conclusions could be drawn as to how the course of one disease might have been affected by the other. The patient's infectious mononucleosis may have responded to antileukemic therapy. The serologic findings provide additional evidence that EB virus may cause infectious mononucleosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONONUCLEOSIS
KW - ACUTE leukemia
KW - EPSTEIN-Barr virus
KW - VIRAL antibodies
KW - DISEASES -- Causes & theories of causation
KW - VIRUS diseases -- Treatment
N1 - Accession Number: 12539935; Deardorff, William L. 1; Gerber, Paul 1; Vogler, William R. 2; Source Information: Feb70, Vol. 72 Issue 2, p235; Subject: MONONUCLEOSIS; Subject: ACUTE leukemia; Subject: EPSTEIN-Barr virus; Subject: VIRAL antibodies; Subject: DISEASES -- Causes & theories of causation; Subject: VIRUS diseases -- Treatment; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Hirschman, R. J.;
AU - Itscoitz, S. B.;
AU - Shulman, N. R.;
T1 - Prophylactic treatment of factor VIII deficiency
CT - Prophylactic treatment of factor VIII deficiency
JO - Blood
JF - Blood
Y1 - 1970/02/01/
VL - 35
IS - Feb
SP - 189
EP - 194
AD - Clinical Hematology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-1584; Language: English; Therapeutic Class: (16:00); AHFS Class: Blood derivatives factor VIII; References: 16; Journal Coden: BLOOAW; Section Heading: Investigational Drugs
N2 - This article describes the prophylactic treatment of factor VIII deficiency with a cryoprecipitate rich in factor VIII. Two patients with classical hemophilia, and twins with a combination of classical hemophilia and von Willebrand's disease, were treated prophylactically with cryoprecipitate for periods up to 2 years. Each had significantly fewer spontaneous hemorrhages during therapy. The prophylactic regimen required to prevent spontaneous hemorrhage was different in each case. Progressive enlargement of an inoperable hemophilic pseudotumor was arrested in one case. Complications included hepatitis in one case and occasional urticaria in another. Prophylactic treatment appears to be practical and indicated in selected cases.
KW - Factor VIII--containing cryoprecipitate-;
KW - Blood derivatives--factor VIII--containing cryoprecipitate, therapy, prophylactic, of factor VIII deficiency;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
T1 - The Immune Response in the Hamster II. STUDIES ON IgM.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 223
EP - 236
SN - 00192805
AB - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN M
KW - IMMUNE response
KW - ANTIGENIC determinants
KW - HAMSTERS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGICAL adjuvants
N1 - Accession Number: 13358132; Coe, J.E. 1; Source Information: Feb70, Vol. 18 Issue 2, p223; Subject: IMMUNOGLOBULIN M; Subject: IMMUNE response; Subject: ANTIGENIC determinants; Subject: HAMSTERS; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGICAL adjuvants; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Stashak, P. W.
AU - Baker, P. J.
AU - Roberson, B. S.
T1 - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice I. ASSAY OF NEUTRALIZING ANTIBODY BY A 50 PER CENT NEUTRALIZATION METHOD.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 295
EP - 305
SN - 00192805
AB - The experimental conditions most suitable for use in the assay of serum neutralizing antibody specific for bacteriophage φX174 by a 50 per cent neutralization method were investigated. Although assays conducted at 37° more readily revealed the presence of background neutralizing activity in the serum of non-immunized germ-free and conventionally reared mice, assays performed at 4° were more suitable for use in detecting the development of newly synthesized neutralizing antibody. In definitive experiments, the SD50 values obtained, i.e. the reciprocal of the serum dilution producing 50 per cent neutralization of added bacteriophage, were found to be directly proportional to the concentration of neutralizing antibody present in serum. The magnitude of the SD50 values obtained suggests that the procedure may be employed advantageously for the detection of very small amounts of antibody and in studies dealing with the kinetics of the antibody response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - BACTERIOPHAGES
KW - IMMUNOGLOBULINS
KW - MICE
KW - IMMUNE serums
KW - IMMUNOLOGY
N1 - Accession Number: 13358436; Stashak, P. W. 1; Baker, P. J. 2; Roberson, B. S. 3; Source Information: Feb70, Vol. 18 Issue 2, p295; Subject: IMMUNE response; Subject: BACTERIOPHAGES; Subject: IMMUNOGLOBULINS; Subject: MICE; Subject: IMMUNE serums; Subject: IMMUNOLOGY; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Stashak, P. W.
AU - Baker, P. J.
AU - Roberson, B. S.
T1 - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice II. KINETICS OF THE SERUM ANTIBODY RESPONSE FOLLOWING PRIMARY IMMUNIZATION.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 307
EP - 317
SN - 00192805
AB - The kinetics of the serum antibody response to various amounts of bacteriophage φX174 were compared in germ-free and conventionally reared mice using a 50 per cent neutralization procedure for the assay of neutralizing antibody. Ten- and 100-fold increases in the amount of φX174 used to immunize resulted in seven and ten-fold increases, respectively, in the amount of antibody produced in conventionally reared mice; however, the same amounts of antigen produced only 1.3- and 1.9-fold increases in germ-free mice. Greater SD50 values, i.e. the reciprocal of the highest dilution of serum which neutralized 50 per cent of the added bacteriophage, were obtained in conventionally reared than germ-flee mice during the later stages of the antibody response; no other significant differences were noted in the kinetics of the response produced in both groups of animals immunized with high doses of antigen. However, neutralizing antibody was produced at a more rapid rate and in larger amounts in germ-free than conventionally reared mice immunized with a low dose of antigen. Regardless of the amount of antigen used to immunize, the time of onset of antibody formation was essentially the same (32-35 hours after injection) in both groups of mice. Conventionally reared mice eliminated antigen at half the rate observed in germ-free mice similarly immunized with high doses of φX174, but with low doses of antigen, no significant differences in elimination rate were noted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - BACTERIOPHAGES
KW - IMMUNOGLOBULINS
KW - MICE
KW - IMMUNE serums
KW - IMMUNOLOGY
N1 - Accession Number: 13358442; Stashak, P. W. 1; Baker, P. J. 2; Roberson, B. S. 3; Source Information: Feb70, Vol. 18 Issue 2, p307; Subject: IMMUNE response; Subject: BACTERIOPHAGES; Subject: IMMUNOGLOBULINS; Subject: MICE; Subject: IMMUNE serums; Subject: IMMUNOLOGY; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Bischoff, K. B.;
AU - Dedrick, R. L.;
AU - Zaharko, D. S.;
T1 - Preliminary model for methotrexate pharmacokinetics
CT - Preliminary model for methotrexate pharmacokinetics
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/02/01/
VL - 59
IS - Feb
SP - 149
EP - 154
SN - 00223549
AD - National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 7-3297; Language: English; Chemical Name: Methotrexate--59-05-2; References: 13; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2 - A pharmacokinetic model is presented to describe the distribution of methotrexate in mice, and the required physicochemical, anatomical, and physiological data are discussed. Methotrexate is excreted in the urine and bile; partial reabsorption occurs in the gastrointestinal tract. Observed bile concentrations were 300 times those of plasma. Models are illustrated.
KW - Methotrexate--body distribution-;
KW - Pharmacokinetics--methotrexate--body distribution, in mice, model presented;
KW - Drugs, body distribution--methotrexate--pharmacokinetic model to describe body distribution, in mice;
KW - Excretion--methotrexate--in urine and bile, partial reabsorption in gastrointestinal tract, in mice;
KW - Models--methotrexate--body distribution, in mice;
KW - Metabolism--methotrexate--body distribution and excretion, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Harbert, J. C.;
AU - Fraley, E. E.;
AU - Deckers, P. J.;
T1 - Alterations in radioactive isotope renogram pattern with urinary bladder filling
CT - Alterations in radioactive isotope renogram pattern with urinary bladder filling
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1970/02/02/
VL - 211
IS - Feb 2
SP - 810
EP - 811
AD - reprints: 3800 Reservoir Road, N.W., Washington, D. C. 20007
AD - Department of Nuclear Medicine and the Surgery Branch, National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 8-0458; Language: English; Chemical Name: Iodohippurate sodium I 131--881-17-4; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals iodohippurate sodium I 131; References: 8; Journal Coden: JAMAAP; Section Heading: Pharmacology; Drug Evaluations
N2 - Patients without renal disease were examined with scintillation camera renography utilizing iodohippurate sodium I 131 with the bladder filled and then emptied. Bladder filling produces a renogram pattern of prolonged transit time which is reproducible with or without catheterization. Patients should be asked to void before radioisotope renography, especially when the patient is given a water load and when more than one study is being performed.
KW - Iodohippurate sodium I 131--renogram pattern-;
KW - Radiopharmaceuticals--iodohippurate sodium I 131--renogram pattern, alterations, with urinary bladder filling;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Mosher, Michael B.
T1 - Spontaneous Lactic Acidosis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/03//
VL - 72
IS - 3
M3 - Letter
SP - 439
EP - 439
SN - 00034819
AB - Presents a letter to the editor commenting on P.P. Oliva and H.A. Schwartz's article entitled 'Survival of a Patient with Spontaneous Lactic Acidosis.'
KW - LETTERS to the editor
KW - ACIDOSIS
KW - LACTIC acid
N1 - Accession Number: 12540806; Mosher, Michael B. 1; Source Information: Mar70, Vol. 72 Issue 3, p439; Subject: LETTERS to the editor; Subject: ACIDOSIS; Subject: LACTIC acid; Number of Pages: 1/6p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Goodell, B.;
AU - Jacobs, B.;
AU - Powell, R. D.;
AU - DeVita, V. T.;
T1 - Pneumocystis carinii: the spectrum of diffuse interstitial pneumonia in patients with neoplastic diseases
CT - Pneumocystis carinii: the spectrum of diffuse interstitial pneumonia in patients with neoplastic diseases
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/03/01/
VL - 72
IS - Mar
SP - 337
EP - 340
SN - 00034819
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-2246; Language: English; Chemical Name: Pentamidine--100-33-4; Therapeutic Class: (8:00); AHFS Class: Antiprotozoals pentamidine; References: 15; Journal Coden: AIMEAS; Section Heading: Investigational Drugs; Abstract Author: Judith A. Kepler
N2 - Prospective experience and retrospective review of diffuse interstitial pneumonia in patients receiving immunosuppressive chemotherapy indicate that Pneumocystis carinii is the most common cause of this form of pneumonia. Patients with underlying malignant disease who are receiving immunosuppressive chemotherapy and who present with diffuse interstitial pneumonia should receive pentamidine isethionate as part of their antimicrobial regimen. Unless contraindicated by uncorrectable thrombocytopenia, every attempt should be made to biopsy involved areas of lung; however, therapy should not be delayed if the diagnosis cannot be confirmed by pulmonary biopsy. Although therapy with pentamidine isethionate is generally well tolerated, the drug is potentially nephrotoxic.
KW - Pentamidine--isethionate-;
KW - Antineoplastic agents--immunosuppressive--patients with underlying malignant disease receiving therapy who present with diffuse interstitial pneumonia, pentamidine isethionate therapy;
KW - Antiprotozoals--pentamidine--isethionate;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Barile, M. F.;
AU - Hardegree, M. C.;
AU - Pittman, M.;
T1 - Immunization against neonatal tetanus in new guinea. 3. The toxin neutralization test and the response of guinea pigs to the toxoids as used in the immunization schedules in New Guinea
CT - Immunization against neonatal tetanus in new guinea. 3. The toxin neutralization test and the response of guinea pigs to the toxoids as used in the immunization schedules in New Guinea
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1970/03/01/
VL - 43
IS - Mar
SP - 453
EP - 459
AD - Bacterial Toxins Section, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-3024; Language: English; Language of Summary: fr; References: 12; Journal Coden: BWHOA6; Section Heading: Methodology
N2 - The mouse toxin-neutralization test procedure has been used for antitoxin titration of sera of New Guinea women following primary immunization with plain and adjuvant tetanus toxoids and following booster immunization, and for titration of guinea pig sera. The responses of guinea pigs immunized with the same toxoids and immunization schedule to simulate the human field trial studies were observed for 6 months. The relative antitoxin responses of guinea pigs to the different toxoids were similar to those of the women.
KW - Tetanus toxoids--immunization-;
KW - Immunization--tetanus--toxoids, against neonatal tetanus, toxin neutralization test and the response of guinea pigs to the toxoids;
KW - Dosage forms--tetanus toxoids--plain and adjuvant, response study using mouse toxin neutralization test;
KW - Tests--toxin neutralization--determination of response to tetanus toxoid dosage forms;
KW - Methodology--toxin neutralization test--in tetanus toxoid immunization;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hardegree, M. C.;
AU - Barile, M. F.;
AU - Pittman, M.;
AU - Maloney, C. J.;
AU - Schofield, F.;
AU - \ET/;
T1 - Immunization against neonatal tetanus in New Guinea. 4. Comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice
CT - Immunization against neonatal tetanus in New Guinea. 4. Comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1970/03/01/
VL - 43
IS - Mar
SP - 461
EP - 468
AD - Bacterial Toxins Section, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 9-3106; Language: English; Language of Summary: fr; References: 30; Journal Coden: BWHOA6; Section Heading: Methodology
N2 - Despite marked variations between passive hemagglutination and mice toxin neutralization tests the results of this study indicated that hemagglutination is a useful procedure for the overall evaluation of the antitoxin response to tetanus toxoids in field studies.
KW - Tetanus toxoids--immunization-;
KW - Immunization--tetanus--neonatal, comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice;
KW - Tests--toxin neutralization--and hemagglutination, in determining tetanus antitoxin titers;
KW - Methodology--tetanus toxoids--comparison of tetanus antitoxin titers obtained by hemagglutination and toxin neutralization in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pittman, M.;
AU - Kolb, R. W.;
AU - Barile, M. F.;
AU - Hardegree, M. C.;
AU - Seligmann, E. B.;
AU - \ET/;
T1 - Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response
CT - Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1970/03/01/
VL - 43
IS - Mar
SP - 469
EP - 478
AD - Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2938; Language: English; Language of Summary: fr; References: 18; Journal Coden: BWHOA6; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2 - This report gives the details of the laboratory assays and extends the time of observation on the relationship of the international #OQ#OQunitage'' to the persistence of the protective antitoxin levels of women injected with aluminum phosphate adsorbed tetanus toxoid to 40 or 54 months after immunization. Previous papers in this series have shown that plain toxoids induced early primary antitoxin levels in women in New Guinea that were not significantly different from those induced by adsorbed toxoids but that at the end of one year the antitoxin levels differed significantly. Protective levels (not less than 0.01 unit/ml.) induced by adsorbed toxoids persisted for more than 3 years. Results of laboratory assays of the toxoids reported in this paper show that per total human immunizing dose, the plain toxoids had 72 or less international units (I.U.) whereas the adsorbed toxoids had approximately 200 I.U. The international unitage of these toxoids reflected the persistence of the human protective antitoxin level but not the early primary response. The assay results were in agreement with findings of other workers that the mouse as well as the guinea pig may be satisfactory for potency assay of adsorbed toxoids. The need for determination of the international unitage of tetanus toxoids used in human studies and the confirmation of the relationship of this value to persistence of antitoxin levels is emphasized.
KW - Tetanus toxoids--potency-;
KW - Tetanus toxoids--immunization-;
KW - Immunization--tetanus--neonatal, laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response;
KW - Dosage forms--tetanus toxoids--adsorbed, and plain, potency;
KW - Standards--tetanus toxoids--need to correlate assay values with human antitoxin response;
KW - Drugs--clinical effectiveness--tetanus toxoids;
KW - Equivalency--tetanus toxoids--adsorbed and plain dosage forms;
KW - Dosage--tetanus toxoids--need for standards;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schrecker, A. W.;
T1 - Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts
CT - Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/03/01/
VL - 30
IS - Mar
SP - 632
EP - 641
SN - 00085472
AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3903; Language: English; Trade Name: Cytosine; Generic Name: Cytarabine; Chemical Name: Cytarabine--147-94-4; References: 44; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - The phosphorylation of cytarabine and other nucleosides and nucleotides was studied in cell-free extracts of leukemia L1210 and in a subline resistant to the drug.
KW - Cytarabine--and other nucleosides and nucleotides-;
KW - Metabolism--cytarabine--and other nucleosides and nucleotides, phosphorylation, in cell-free extracts of leukemia L1210 and in resistant subline;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, B. G.;
AU - Swart, B. E.;
T1 - Evidence for the presence of anti-Burkitt tumor globulins in pooled human immune globulins
CT - Evidence for the presence of anti-Burkitt tumor globulins in pooled human immune globulins
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/03/01/
VL - 30
IS - Mar
SP - 763
EP - 767
SN - 00085472
AD - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3902; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents globulins; References: 15; Journal Coden: CNREA8; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2 - Twenty lots of commercially pooled human globulins were found to suppress the growth of EB3 and other cells derived from Burkitt's lymphoma and human leukemias. This observation suggests that passive immunity to these conditions might be obtained with #OQ#OQnormal'' immune human globulin.
KW - Globulins--immune--pooled human, evidence for presence of anti-Burkitt tumor globulins;
KW - Antineoplastic agents--globulins--immune, pooled human, evidence for presence of anti-Burkitt tumor globulins;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levine, P. H.;
AU - Regelson, W.;
AU - Holland, J. F.;
T1 - Chloramphenicol-associated encephalopathy
CT - Chloramphenicol-associated encephalopathy
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/03/01/
VL - 11
IS - Mar-Apr
SP - 194
EP - 199
SN - 00099236
AD - Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3131; Language: English; Chemical Name: Chloramphenicol--56-75-7; References: 36; Journal Coden: CLPTAT; Section Heading: Adverse Drug Reactions; Abstract Author: Monte S. Cohon
N2 - Oral chloramphenicol as a causative agent of toxic delirium in 3 patients is discussed. Cessation of therapy resulted in disappearance of the symptoms. When the drug was resumed, symptoms reappeared. The same dosage of chloramphenicol parenterally did not result in encephalopathy.
KW - Chloramphenicol--adverse reactions-;
KW - Drugs, adverse reactions--chloramphenicol--oral, associated encephalopathy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kalser, S.;
AU - McLain, P. L.;
T1 - Atropine metabolism in man
CT - Atropine metabolism in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/03/01/
VL - 11
IS - Mar-Apr
SP - 214
EP - 227
SN - 00099236
AD - National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
N1 - Accession Number: 7-3295; Language: English; Chemical Name: Atropine--51-55-8; References: 17; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2 - Administration of two 14C-tropine-labeled atropines to man shows the urinary excretion of 77 to 93% of the injected dose in 24 hours. Only the N-methyl-14C but not the 2,4-14C-atropine shows oxidation to 14CO2 with a respiratory elimination of 3% in 3 hours. Atropine disappears very rapidly from the blood. Urinary excretion over the first 24 hours occurs at 2 rates; a fast rate occurring first with a t1/2 of about 2 hours and a slow rate with a t1/2 of about 13 to 38 hours. The early urine samples show the major fraction of the 14C existing as a chromatographic component which is a beta-glucuronide. The urines collected at later periods (4 to 8 hours) contain little, if any, of this component. The chromatographically distinguishable 14C-containing urinary components do not differ between the two 14C-atropines.
KW - Atropine--14C-tropine-labeled-;
KW - Metabolism--atropine--14C-tropine-labeled, derivatives;
KW - Excretion--atropine--14C-tropine-labeled, derivatives;
KW - Blood levels--atropine--14C-tropine-labeled, derivatives;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Slagle, James R.
AU - Dixon, John K.
T1 - Experiments with the M & N Tree-Searching Program
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1970/03//
VL - 13
IS - 3
M3 - Article
SP - 147
PB - Association for Computing Machinery
SN - 00010782
AB - The m & n procedure is an improvement to the mini-max backing-up procedure widely used in computer programs for game-playing and other purposes. It is based on the principle that it is desirable to have many options when making decisions in the face of uncertainty. The mini-max procedure assigns to a max (min) node the value of the highest (lowest) valued successor to that node. The m & n procedure assigns to a max (min) node some function of the m (n) highest (lowest) valued successors. An m & n procedure was written in lisp to play the game of kalah, and it was demonstrated that the m & n procedure is significantly superior to the mini-max procedure. The statistical significance of important conclusions is given. Since information on statistical significance has often been lacking in papers on computer experiments in the artifical intelligence field, these experiments can perhaps serve as a model for future work.
KW - COMPUTER programs
KW - GAME theory
KW - LISP (Computer program language)
N1 - Accession Number: 5355292; Slagle, James R.; Dixon, John K. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: Mar70, Vol. 13 Issue 3, p147; Note: Publisher: Association for Computing Machinery; Note: Update Code: 0500; Subject Term: COMPUTER programs; Subject Term: GAME theory; Subject Term: LISP (Computer program language); Number of Pages: 9p; Illustrations: 2 charts, 4 diagrams; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Robinson, John P.
T1 - PUBLIC REACTION TO POLITICAL PROTEST: CHICAGO 1968.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1970///Spring70
VL - 34
IS - 1
M3 - Article
SP - 1
EP - 9
PB - Oxford University Press / USA
SN - 0033362X
AB - Despite press and television coverage largely sympathetic to antiwar demonstrators who clashed with Chicago police on August 28, 1968, public opinion remained overwhelmingly unsympthetic. Here, John P. Robinson examines two main questions: Who comprised the minority sympathetic to the demonstrators? How did attitudes toward the protesters and the police affect presidential voting behavior in November 1968, particularly among Democrats and Independents, whose voting behavior was most likely to be affected by the events in Chicago? [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Demonstrations (Collective behavior)
KW - Public opinion
KW - Crowds
KW - Peace movements
KW - Chicago (Ill.)
KW - Illinois
N1 - Accession Number: 5415627; Robinson, John P. 1,2,3; Affiliations: 1: Study Director, Survey Research Center; 2: Assistant Professor, Department of Journalism, University of Michigan; 3: Research Coordinator, Surgeon General's Television and Social Behavior Program, National Institute of Mental Health; Issue Info: Spring70, Vol. 34 Issue 1, p1; Thesaurus Term: Demonstrations (Collective behavior); Thesaurus Term: Public opinion; Subject Term: Crowds; Subject Term: Peace movements; Subject: Chicago (Ill.); Subject: Illinois; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 84005688
T1 - Detection of growth-hormone deficiency.
AU - Mitchell, M. L.
AU - Byrne, M. J.
AU - Sanchez, Y.
AU - Sawin, C. T.
Y1 - 1970/03/05/
N1 - Accession Number: 84005688. Language: English. Entry Date: 20161118. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Human Growth Hormone -- Blood
KW - Hypopituitarism -- Diagnosis
KW - Glucagon -- Administration and Dosage
KW - Injections, Intramuscular
KW - Hypopituitarism -- Blood
KW - Pituitary Diseases -- Blood
KW - Injections, Subcutaneous
KW - Chemical and Pharmacologic Phenomena
KW - Male
KW - Female
KW - Radioimmunoassay
KW - Time Factors
SP - 539
EP - 541
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 282
IS - 10
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Supported by a research grant (AM-12640) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, and by Part I Research Funds from the Veterans Administration Medical Research and Education Service, Veterans Administration Central Office, Washington, D.C.
U2 - PMID: 5413105.
DO - 10.1056/NEJM197003052821005
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Oren, M. E.;
AU - Herberman, R. B.;
AU - Rogentine, G. N., Jr.;
T1 - Effect of heparin on the detection of human isoantigens by the cytotoxicity technique
CT - Effect of heparin on the detection of human isoantigens by the cytotoxicity technique
JO - Nature (London)
JF - Nature (London)
Y1 - 1970/03/07/
VL - 225
IS - Mar 7
SP - 951
EP - 952
AD - Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-4142; Language: English; Chemical Name: Heparin--9005-49-6; References: 31; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2 - Heparin, by coating the cell surface or some other mechanism, may have a significant influence on immunological reaction involving mouse cells, but does not seem to have significant effects on human lymphocytes.
KW - Heparin--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mendell, J. R.;
AU - Chase, T. N.;
AU - Engel, W. K.;
T1 - Modification by L-dopa of a case of progressive supranuclear palsy
CT - Modification by L-dopa of a case of progressive supranuclear palsy
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1970/03/21/
VL - 1
IS - Mar 21
SP - 593
EP - 594
SN - 00237507
AD - Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, and Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2052; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 13; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Lamar Orr
N2 - A case of progressive supranuclear palsy is reported in which the biochemical findings were suggestive of a defect in cerebral dopamine metabolism, and whose neurological state improved on treatment with L-dopa (levodopa).
KW - Levodopa--progressive supranuclear palsy-;
KW - Antiparkinson agents--levodopa--modification of case of progressive supranuclear palsy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Curran, R. E.;
AU - Johnson, R. E.;
T1 - Tolerance to chemotherapy after prior irradiation for Hodgkin's disease
CT - Tolerance to chemotherapy after prior irradiation for Hodgkin's disease
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/04/01/
VL - 72
IS - Apr
SP - 505
EP - 509
SN - 00034819
AD - Radiation Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-2235; Language: English; References: 15; Journal Coden: AIMEAS; Section Heading: Toxicity
N2 - Although intensive radiotherapy is generally well tolerated by patients with Hodgkin's disease, such treatment significantly reduces the bone marrow reserve. The hematologic tolerance to chemotherapy was evaluated in patients who had received prior irradiation. The important factors in determining the postirradiation tolerance to chemotherapy were extent of bone marrow irradiated and the time interval from completion of radiotherapy to onset of chemotherapy. Inability to deliver adequate chemotherapy after extensive radiotherapy was associated with both failure to achieve drug-induced remissions and limited survival times. This experience serves to emphasize the necessity for a rigorous diagnostic evaluation for each patient before institution of radical radiotherapy. Failure to carefully investigate the extent of disease, especially with respect to extranodal involvement, can only result in a radiation-induced reduction of bone marrow reserve which may prevent the subsequent administration of effective (though palliative) chemotherapy.
KW - Irradiation--Hodgkin's disease--therapy, tolerance to subsequent chemotherapy;
KW - Drugs--Hodgkin's disease--therapy, tolerance to chemotherapy after prior irradiation;
KW - Antineoplastic agents--Hodgkin's disease--therapy, tolerance to chemotherapy after prior irradiation;
KW - Toxicity studies--tolerance to chemotherapy after prior irradiation for Hodgkin's disease;
KW - Drug interactions--irradiation--tolerance to subsequent chemotherapy, for Hodgkin's disease;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Epstein, S. E.;
AU - Skelton, C. L.;
AU - Levey, G. S.;
AU - Entman, M.;
T1 - Adenyl cyclase and myocardial contractility
CT - Adenyl cyclase and myocardial contractility
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/04/01/
VL - 72
IS - Apr
SP - 561
EP - 578
SN - 00034819
AD - National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-3629; Language: English; References: 76; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - The activity of many hormones can be related to their capacity to increase adenyl cyclase activity in their target organs. Evidence that the augmentation of myocardial contractility produced by catecholamines is mediated by adenyl cyclase activation is summarized. Glucagon and thyroid hormone also enhance myocardial adenyl cyclase activity, findings compatible with the hypothesis that activation of this enzyme may also be responsible for the increased contractility produced by glucagon and associated with hyperthyroidism. The inotropic action of epinephrine and glucagon may be due to an increase in sarcotubular calcium stores, an effect that appears to be related to activation of an adenyl cyclase in the microsomal fraction. Chronic cardiac decompensation did not alter the capacity of norepinephrine to enhance contractility or activate adenyl cyclase, but it markedly impaired the capacity of glucagon to elicit these responses. Thus, glucagon may have limited value in the treatment of patients with chronic heart failure.
KW - Hormones--effects--related to adenyl cyclase activity in target organs;
KW - Mechanism of action--hormones--effects, related to adenyl cyclase activity in target organs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, C. H., III;
AU - Stashick, E.;
AU - Carbone, P. P.;
T1 - Clinical efficacy and lack of toxicity of allopurinol (NSC-1390) given intravenously
CT - Clinical efficacy and lack of toxicity of allopurinol (NSC-1390) given intravenously
JO - Cancer Chemother. Rept.
JF - Cancer Chemother. Rept.
Y1 - 1970/04/01/
VL - 54
IS - Apr
SP - 125
EP - 129
AD - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-4084; Language: English; Trade Name: NSC-1390; Generic Name: Allopurinol; Chemical Name: Allopurinol--315-30-0; References: 4; Journal Coden: CNCRA6; Section Heading: Drug Evaluations; Abstract Author: Paul J. Miller
N2 - Allopurinol given intravenously in very high doses to 16 patients produced no apparent clinical toxicity. The patients received allopurinol as prophylaxis against and treatment for hyperuricemia. Dosages ranged from 105 mg./m.2/24 hours for 4 days to 660 mg./m.2/24 hours for 11 days. The results of the study showed definite therapeutic activity, but no serious drug toxic effects.
KW - Allopurinol--hyperuricemia-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haskell, C. M.;
AU - Canellos, G. P.;
T1 - Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists
CT - Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/04/01/
VL - 30
IS - Apr
SP - 1081
EP - 1083
SN - 00085472
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 8-3824; Language: English; Chemical Name: Asparagine--7006-34-0 Glutamine--6899-04-3 Norleucine--327-57-1; References: 18; Journal Coden: CNREA8; Section Heading: Drug Interactions; Pharmacology; Abstract Author: Jimmie L. Hall
N2 - In this experiment, the effect of various asparagine or glutamine antagonists on asparagine synthetase levels in vitro was studied. Theoretically, the antineoplastic effect of asparaginase could be enhanced by the concurrent administration of an agent which inhibits asparagine synthetase, thus inhibiting the synthesis of L-asparagine from L-aspartic acid. In this experiment, the effect of various compounds on asparagine synthetase levels was determined in human tumor cells in vitro. The asparagine analogs, DL-aspartic acid-\b/-hydroxamic acid (DL-BAH), and 5-diazo-4-oxo-L-norvaline (DONV), as well as L-asparagine itself reduced enzyme levels. Presumably, however, these compounds would be destroyed by L-asparaginase if given concurrently with it. Moreover, DONV binds irreversably with asparaginase and renders it inactive. Of the glutamine analogs, 6-diazo-5-oxo-L-norleucine (DON) and azotomycin markedly reduced enzyme levels, while duazomycin A and azaserine did so only slightly. Asparagine synthetase levels were neither increased nor decreased by puromycin. The implications of combining these drugs with asparaginase are discussed.
KW - Asparagine--antagonists-;
KW - Glutamine--antagonists-;
KW - Norleucine--6-diazo-5-oxo-L--;
KW - Azotomycin--effects-;
KW - Enzyme inhibitors--asparagine--antagonists, effects on asparagine synthetase levels, in human tumor cells, in vitro;
KW - Enzyme antagonists--glutamine--antagonists, effects on asparagine synthetase levels, in human tumor cells, in vitro;
KW - Drug interactions--asparaginase--and other drugs, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Levine, S.
AU - Hoenig, E. M.
AU - Kies, Marian W.
T1 - ALLERGIC ENCEPHALOMYELITIS: IMMUNOLOGICALLY SPECIFIC INHIBITION OF CELLULAR PASSIVE TRANSFER BY ENCEPHALITOGENIC BASIC PROTEINS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1970/04//
VL - 6
IS - 4
M3 - Article
SP - 503
EP - 517
SN - 00099104
AB - Passive transfer of experimental allergic encephalomyelitis (EAE) was performed with lymph node cells from donor rats immunized with spinal cord or purified encephalitogenic basic protein and any of several adjuvant combinations. Transfer was inhibited by injection of recipients with the brain basic protein. Basic proteins from rat and guinea-pig CNS inhibited transfer from donors immunized with rat or guinea-pig spinal cord or basic protein. Monkey basic protein inhibited transfer from donors immunized with monkey or human cord. There was only partial cross-inhibition between rodent and primate groups. The inhibition was organ specific in that basic proteins from lung, spleen and adrenal did not inhibit transfer of EAE. Furthermore, transfer of adrenalitis from donors immunized with adrenal tissue was inhibited by adrenal extracts but not by CNS basic protein. Pertussis and typhoid vaccines injected into recipients inhibited transfer of either EAE or adrenalitis. This non-specific inhibition was also demonstrated after simultaneous transfer of both EAE and adrenalitis, whereas CNS basic protein eliminated only EAE in such recipients. Inhibition was complete in experiments terminated one day after transfer. In longer experiments, inhibition lasted only 3 or 4 days. Basic protein was rapidly cleared from the blood. Neither spleen nor adrenals were necessary for its action. Brain basic protein prevented the interaction between encephalitogenic cells and the target Organ by an immunologically specific mechanism which may be a type of desensitization. The inhibition could not be reproduced in vitro. Bioassay and radioactive tracers revealed that basic protein bound non-specifically to living or dead lymph node cells in vitro. The effects of incubation could be accounted for by this non-specific carry-over of basic protein into the recipients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENCEPHALOMYELITIS
KW - LYMPH
KW - DEMYELINATION
KW - PROTEINS
KW - CENTRAL nervous system -- Diseases
KW - LYMPHOID tissue
N1 - Accession Number: 14587029; Levine, S. 1,2; Hoenig, E. M. 1,2; Kies, Marian W. 1,2; Source Information: Apr70, Vol. 6 Issue 4, p503; Subject: ENCEPHALOMYELITIS; Subject: LYMPH; Subject: DEMYELINATION; Subject: PROTEINS; Subject: CENTRAL nervous system -- Diseases; Subject: LYMPHOID tissue; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY -
AU - Read, Merrill S.1
T1 - Malnutrition and Learning.
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1970/04//
Y1 - 1970/04//
VL - 35
IS - 8
CP - 8
M3 - Article
SP - 8
EP - 11
SN - 0013127X
AB - The article discusses various issues related to malnutrition and learning in the U.S. Malnutrition is a state in which an individual lacks one or more nutrients to the extent that specific symptoms and conditions appear, or retardation in physical development occurs. It is informed that the National Nutrition Survey, begun in 1968 and being carried out by the U.S. Department of Health, Education, and Welfare. It was the first comprehensive effort to assess the nutritional status of the U.S. population. Preliminary results have been reported on the study of 12,000 people of all ages, randomly selected in poverty pockets in two states and several smaller areas. The survey found an unexpectedly high prevalence of symptoms associated with malnutrition. In an eight-year study of Mexican children, investigators found that intellectual performance at the time of entry into school appeared to be related to the child's history of malnutrition. After the children spent four to five years in school, however, this relationship disappeared, and differences in performance appeared more closely related to socioeconomic conditions and regularity of school attendance.
KW - Malnutrition
KW - Education -- United States
KW - Intellect
KW - School attendance
KW - Nutrition disorders
KW - United States
N1 - Accession Number: 18844736; Authors: Read, Merrill S. 1; Affiliations: 1: Program Director, Growth and Development Branch, National Institute of Child Health and Human Development, Bethesda, Maryland.; Subject: Malnutrition; Subject: Education -- United States; Subject: Intellect; Subject: School attendance; Subject: Nutrition disorders; Subject: United States; Number of Pages: 4p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Colten, H.R.
AU - Borsos, T.
AU - Rapp, H.J.
T1 - Isoelectric Focusing of Human and Guinea-Pig C2: Polymorphism of Guinea-Pig C2.
JO - Immunology
JF - Immunology
Y1 - 1970/04//
VL - 18
IS - 4
M3 - Article
SP - 467
EP - 472
SN - 00192805
AB - The isoelectric point (pI) of human and guinea-pig C2 was determined by electrofocusing. The results showed that human C2 and C2 of some guinea-pigs had a pi of approximately pH 5-5-5·6; in some guinea-pig sera C2 activity was resolved into two fractions, one with a pi of about 5·2 and the other of about 5·5. The data suggest the possibility that guinea-pig C2 may exist in at least two allotypic forms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPLEMENT (Immunology)
KW - BLOOD proteins
KW - ISOELECTRIC focusing
KW - GUINEA pigs
KW - IMMUNOLOGY
KW - SEPARATION (Technology)
N1 - Accession Number: 13358591; Colten, H.R. 1; Borsos, T. 1; Rapp, H.J. 1; Source Information: Apr70, Vol. 18 Issue 4, p467; Subject: COMPLEMENT (Immunology); Subject: BLOOD proteins; Subject: ISOELECTRIC focusing; Subject: GUINEA pigs; Subject: IMMUNOLOGY; Subject: SEPARATION (Technology); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Von Sallmann, L.;
AU - Grimes, P.;
T1 - Cataractogenic effect of dibromomannitol in rats
CT - Cataractogenic effect of dibromomannitol in rats
JO - Invest. Ophthalmol.
JF - Invest. Ophthalmol.
Y1 - 1970/04/01/
VL - 9
IS - Apr
SP - 291
EP - 299
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-2679; Language: English; References: 13; Journal Coden: INOPAO; Section Heading: Toxicity; Abstract Author: James W. Dungee
N2 - Presented is a study of the effect of dibromomannitol (DBM) on the corneas of a group of rats. A single dose (1 g./kg.) of DBM, administered to a group of rats resulted in no cataracts during a one-month examination period. A chronic dose of 90 mg. per kg. daily, administered over a number of days to another group of rats, resulted in no cataracts after one month, but mild epithelial damage. A chronic dose of 180 mg. per kg. daily fed to another group of rats resulted in cataracts in the majority of the group, after 4 weeks.
KW - Dibromomannitol--cataractogenic effect-;
KW - Toxicity studies--dibromomannitol--cataractogenic effect, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lowenbraun, S.;
AU - Young, V.;
AU - Kenton, D.;
AU - Serpick, A. A.;
T1 - Infection from intravenous #OQ#OQscalp-vein'' needles in a susceptible population
CT - Infection from intravenous #OQ#OQscalp-vein'' needles in a susceptible population
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1970/04/20/
VL - 212
IS - Apr 20
SP - 451
EP - 453
AD - Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 8-0938; Language: English; References: 8; Journal Coden: JAMAAP; Section Heading: Environmental Toxicity
N2 - Intravenous indwelling scalp-vein needles were cultured in a population with neoplastic disease. Twenty-four of the 74 needles cultured were positive; microorganisms generally considered pathogenic grew from 7 of these needles. The latter organisms included \IT/Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans\OK/, \a/-hemolytic Streptococcus, and group D Streptococcus. Infected scalp-vein needles were the bacteriologic source in one case of septicemia and one case of cellulitis. There was a trend toward increasing incidence of growth with increasing duration of needle placement.
KW - Needles--scalp-vein--intravenous indwelling, pathogenic contamination;
KW - Contamination--needles--scalp-vein, intravenous indwelling, by pathogenic microorganisms;
KW - Toxicity--needles--scalp-vein, intravenous indwelling, pathogenic contamination;
KW - Toxicity, environmental--needles--scalp-vein, intravenous indwelling, pathogenic contamination;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lowenbraun, Stanley
AU - Ramsey, Harold
AU - Sutherland, John
AU - Serpick, Arthur A.
T1 - Diagnostic Laparotomy and Splenectomy for Staging Hodgkin's Disease.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/05//
VL - 72
IS - 5
M3 - Article
SP - 655
EP - 663
SN - 00034819
AB - Diagnostic laparotomies and splenectomies were performed on 12 patients to determine more accurately the extent of Hodgkin's disease in the abdomen. Preoperatively, the patients were carefully staged as recommended by the Rye Conference in 1966. At laparotomy four out of nine positive lymphograms were uncorroborated by surgical findings and biopsies, as was one positive inferior vena cavogram. Splenic disease was found in four out of six patients whose preoperative evaluations were negative in this regard. Hodgkin's infiltration of porta hepatic, splenic hilar, and mesenteric lymph nodes was found in three, two, and one patient, respectively. In one patient a retroperitoneal mass was discovered that extended 4 cm laterally to nodes visualized by lymphography and outside usual fields for radiotherapy. None of the hepatic wedge biopsies were positive. Three patients had their stages changed on the basis of laparotomy findings, and an additional seven patients had changes in their known extent of lymphomatous involvement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ABDOMINAL surgery
KW - SPLENECTOMY
KW - HODGKIN'S disease
KW - EXCISION (Surgery)
KW - SPLEEN -- Surgery
KW - LYMPHOMAS
N1 - Accession Number: 12556452; Lowenbraun, Stanley 1; Ramsey, Harold 1; Sutherland, John 1; Serpick, Arthur A. 1; Source Information: May70, Vol. 72 Issue 5, p655; Subject: ABDOMINAL surgery; Subject: SPLENECTOMY; Subject: HODGKIN'S disease; Subject: EXCISION (Surgery); Subject: SPLEEN -- Surgery; Subject: LYMPHOMAS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Letz, F. H.;
AU - Stefano, F. J. E.;
T1 - Desipramine-induced release of norepinephrine from heart
CT - Desipramine-induced release of norepinephrine from heart
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1970/05/01/
VL - 19
IS - May
SP - 1797
EP - 1801
AD - Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0045; Language: English; Chemical Name: Desipramine--50-47-5; References: 21; Journal Coden: BCPCA6; Section Heading: Pharmacology
N2 - Desipramine (DMI) in low concentrations inhibits the uptake of norepinephrine (NE) by sympathetic nerve endings but does not release the amine. In high concentrations, however, DMI releases NE. The rate of NE release from heart slices depends on the DMI concentration; at 25 mcg./ml., the NE stores are depleted by 50% in 4 hours; at 50 mcg./ml., they are depleted by 50% in one hour. In the isolated heart, DMI releases the NE mainly in the form of deaminated metabolites, indicating that the drug acts within the neuron, possibly on the storage granules.
KW - Desipramine--induced release of norepinephrine-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - German, L. G.;
T1 - Microbiology of the intimate environment
CT - Microbiology of the intimate environment
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1970/05/01/
VL - 24
IS - May-Jun
SP - 105
EP - 109
AD - Environmental Services Branch, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-2432; Language: English; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - The role of bacteria, yeasts, molds, and viruses in, on, and around a drug production area can be both fascinating and hazardous. Although antibiotics and chemicals may be used to control microbial growth, not all patients can tolerate them. Physical equipment and methods that can maintain safe microbial levels are discussed.
KW - Control--microbiological--equipment and methods for maintaining safe microbial levels;
KW - Microorganisms--control--equipment and methods for maintaining safe microbial levels;
KW - Equipment--and methods for maintaining safe microbial levels;
KW - Contamination--microbiological--equipment and methods for maintaining safe microbial levels;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sandberg, J. S.;
AU - Goldin, A.;
T1 - Use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate
CT - Use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/05/01/
VL - 30
IS - May
SP - 1276
EP - 1280
SN - 00085472
AD - Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 7-4544; Language: English; Trade Name: Citrovorum factor; Generic Name: Leucovorin; Chemical Name: Leucovorin--58-05-9 Methotrexate--59-05-2; References: 24; Journal Coden: CNREA8; Section Heading: Drug Interactions; Abstract Author: Jimmie L. Hall
N2 - Citrovorum factor (leucovorin) is used parenterally to reduce the toxicity of methotrexate. This study demonstrates that, in mice, this protective effect is retained when the drug is given orally.
KW - Leucovorin--oral-;
KW - Methotrexate--toxicity-;
KW - Dosage forms--leucovorin--oral, use in normal and leukemic mice to prevent toxicity and GI lesions caused by high doses of methotrexate;
KW - Toxicity--methotrexate--caused by high doses in normal and leukemic mice, protective effect of oral leucovorin;
KW - Drug interactions--methotrexate--use of oral leucovorin to prevent the toxicity and GI lesions caused by high doses, in normal and leukemic mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Oliverio, V. T.;
AU - Vietzke, W. M.;
AU - Williams, M. K.;
AU - Adamson, R. H.;
T1 - Absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals
CT - Absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/05/01/
VL - 30
IS - May
SP - 1330
EP - 1337
SN - 00085472
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0268; Language: English; Chemical Name: Urea--57-13-6; References: 21; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Investigational Drugs
N2 - This article reports studies of the disposition of labeled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in mice, rats, dogs, and monkeys. Determinations were made with the \SU/14\BS/C label in each of 3 positions of the molecule, the ethylene, carbonyl, and cyclohexyl moieties. CCNU is lipid soluble, and after parenteral dosage, rapidly degraded in mouse and dog plasma with 2 exponential phases. The half-life of the initial phase is about 5 minutes, while the second phase extends over one hour. During the 6 hours after I.V. injection of ethylene-labeled CCNU in dogs, radioactivity in the cerebrospinal fluid exceeded that of plasma 3-fold. Wth the label in the cyclohexyl moiety, plasma radioactivity was about 50% of cerebrospinal fluid levels. Following biotransformation, the drug is excreted primarily by the kidneys, with excretion being essentially complete during the first 24 hours in rodents and monkeys, but more protracted in dogs. Biliary secretion and reabsorption from the gastrointestinal tract have been demonstrated. The cyclohexyl portion of the molecule was bound extensively to plasma proteins of dogs, while the ethylene moiety was not.
KW - Urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso--;
KW - Absorption--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW - Drugs, body distribution--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW - Excretion--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
KW - Metabolism--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in animals;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Colvin, M.;
AU - Bono, V. H., Jr.;
T1 - Enzymatic reduction of hydroxyurea to urea by mouse liver
CT - Enzymatic reduction of hydroxyurea to urea by mouse liver
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/05/01/
VL - 30
IS - May
SP - 1516
EP - 1519
SN - 00085472
AD - Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0267; Language: English; Chemical Name: Hydroxyurea--127-07-1; References: 20; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Jimmie L. Hall
N2 - This study reports that hydroxyurea is enzymatically reduced to urea by mouse liver tissue and that this reaction occurs to a large extent in the hepatic mitochondria.
KW - Hydroxyurea--metabolism-;
KW - Metabolism--hydroxyurea--enzymatic reduction to urea, by mouse liver;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Martin, W. R.;
AU - Hoeldtke, R. D.;
T1 - Effects of short and long-term administration of pentazocine in man
CT - Effects of short and long-term administration of pentazocine in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/05/01/
VL - 11
IS - May-Jun
SP - 385
EP - 403
SN - 00099236
AD - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 7-3219; Language: English; Chemical Name: Pentazocine--359-83-1; References: 31; Journal Coden: CLPTAT; Section Heading: Pharmacology
N2 - Pentazocine produces morphine-like subjective effects. A dose of 60 mg. per 70 kg. produces subjective effects which more closely resemble those of nalorphine than those of morphine. Pentazocine will not suppress abstinence symptoms in subjects dependent on either 60 or 240 mg. per day of morphine. Pentazocine is 1/50 as potent as nalorphine in precipitating abstinence symptoms in subjects dependent on 240 mg. of morphine per day. Long-term administration of pentazocine produces dependence which has elements of both morphine and nalorphine dependence. It is concluded that pentazocine has an abuse potential which is less than that with morphine but greater than that with nalorphine.
KW - Pentazocine--effects-;
KW - Dependence--pentazocine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
T1 - SLEEP CYCLES AND SKIN POTENTIAL IN NEWBORNS STUDIED WITH A SIMPLIFIED OBSERVATION AND RECORDING SYSTEM.
AU - Bell, Richard Q.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1970/05//
VL - 6
IS - 6
SP - 778
EP - 786
SN - 00485772
N1 - Accession Number: 11049746; Author: Bell, Richard Q.: 1 ; Author Affiliation: 1 National Institute of Mental Health.; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20031223
N2 - A simple visual observation system, supplemented by measurement of skin potential, was devised for developmental studies of sleep cycles in settings where multiple electrode placement is not practicable. The findings replicated essential features of quiet and active sleep cycles which had been reported previously to exist against the background of decreasing level of physiological arousal, as sleep proceeds. Twelve newborns showed approximately one-half of their interfeeding sleeping time in the rapid eye movement stage of sleep. Skin potential rapidly declined from the waking level, continued to decrease in level throughout sleep, increased in variability during REM sleep, and increased in level at the second waking period. ABSTRACT FROM AUTHOR
KW - *GALVANIC skin response
KW - *REFLEXES
KW - *SLEEP
KW - *ELECTROPHYSIOLOGY
KW - NEWBORN infants
KW - Newborns.
KW - Skin potential
KW - Sleep
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
TY - GEN
AU - Courtney, K. D.;
AU - Gaylor, D. W.;
AU - Hogan, M. D.;
AU - Falk, H. L.;
AU - Bates, R. R.;
AU - \ET/;
T1 - Teratogenic evaluation of 2,4,5-T
CT - Teratogenic evaluation of 2,4,5-T
JO - Science
JF - Science
Y1 - 1970/05/15/
VL - 168
IS - May 15
SP - 864
EP - 866
AD - National Institute of Environmental Health Sciences, National Institutes of Health, P. O. Box 12233, Research Triangle Park, North Carolina 27709
N1 - Accession Number: 8-0132; Language: English; References: 6; Journal Coden: SCIEAS; Section Heading: Toxicity
N2 - The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in 2 strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally.
KW - Trichlorophenoxyacetic acid--2,4,5--;
KW - Teratogenicity--trichlorophenoxyacetic acid--2,4,5-, in rodents;
KW - Toxicity--trichlorophenoxyacetic acid--2,4,5-, teratogenic and fetocidal effects, in rodents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kannel, William B.
AU - Gordon, Tavia
AU - Castelli, William P.
AU - Margolis, James R.
T1 - Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/06//
VL - 72
IS - 6
M3 - Article
SP - 813
EP - 822
SN - 00034819
AB - Risk of clinically overt coronary heart disease in 190 persons with "definite" and 264 with "possible" electrocardiographic left ventricular hypertrophy (ECG-LVH) was compared with that of a total cohort of 5,127 men and women followed over 14 years. Prevalence of both coronary heart disease and ECG-LVH increased in proportion to antecedent blood pressure. Persons who acquired "definite'' ECG-LVH had a residual threefold increased risk of clinically overt coronary heart disease after adjustment for the effect of coexisting hypertension. "Possible" ECG-LVH was associated with a twofold increased risk, but this was virtually obliterated on adjustment for hypertension. Risk of every clinical manifestation of coronary heart disease, and of death in particular, was increased, and 40% with prior ECG-LVH died in their initial attack, a fatality rate comparable with that of persons with prior overt coronary heart disease. ECG-LVH is thus a grave prognostic sign and a harbinger of clinically overt coronary heart disease, it is tempting to hypothesize that ECG-LVH without other explanation based mainly on increased voltage (possible LVH)is largely an expression of hypertensive hypertrophy and that with more marked voltage increases accompanied by S-T and T wave abnormality (definite LVH) indicates ischemic myocardial involvement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTROCARDIOGRAPHY
KW - HYPERTROPHY
KW - CORONARY heart disease
KW - LEFT heart ventricle
KW - ELECTRODIAGNOSIS
KW - PATHOLOGY
N1 - Accession Number: 12584323; Kannel, William B. 1; Gordon, Tavia 1; Castelli, William P. 1; Margolis, James R. 1; Source Information: Jun70, Vol. 72 Issue 6, p813; Subject: ELECTROCARDIOGRAPHY; Subject: HYPERTROPHY; Subject: CORONARY heart disease; Subject: LEFT heart ventricle; Subject: ELECTRODIAGNOSIS; Subject: PATHOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Satterlee, Winston G.
AU - Serpick, Arthur
AU - Bianchine, Joseph R.
T1 - The Carcinoid Syndrome: Chronic Treatment with Para-Chlorophenylalanine.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/06//
VL - 72
IS - 6
M3 - Article
SP - 919
EP - 921
SN - 00034819
AB - Para-chlorophenylalanine is a potent depleter of tissue serotonin (5-hydroxytryptamine). Since 5-hydroxytryptamine may contribute to the pathogenesis of several aspects of the carcinoid syndrome, for 1 year we treated a patient with this syndrome with para-chlorophenylalanine. A 59-year-old man developed chronic diarrhea, hepatomegaly, right-sided valvular heart lesion, and cutaneous flush. Exploratory abdominal examination showed ileal carcinoid tumor metastatic to liver and nodes. Urine 5-hydroxyindoleacetic acid and serum 5-hydroxytryptamine levels were abnormally high. Para-chlorophenylalanine treatment promptly reduced both levels to normal and halted the diarrhea. Chronic treatment with para-chlorophenylalanine controlled the production of 5-hydroxytryptamine and diarrhea but did not prevent tumor growth, flushing; or progression of cardiac lesions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOID
KW - PHENYLALANINE
KW - SEROTONIN
KW - CHROMAFFIN cells -- Tumors
KW - NEUROENDOCRINE tumors
KW - AMINO acids
N1 - Accession Number: 12584380; Satterlee, Winston G. 1; Serpick, Arthur 1; Bianchine, Joseph R. 1; Source Information: Jun70, Vol. 72 Issue 6, p919; Subject: CARCINOID; Subject: PHENYLALANINE; Subject: SEROTONIN; Subject: CHROMAFFIN cells -- Tumors; Subject: NEUROENDOCRINE tumors; Subject: AMINO acids; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Vogel, C. L.;
AU - Denham, C.;
AU - Waalkes, T. P.;
AU - DeVita, V. T.;
T1 - Physiological disposition of the carcinostatic imidazole-4(or5)-carboxamide, 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno](NSC-82196) (imidazole mustard) in mice and dogs
CT - Physiological disposition of the carcinostatic imidazole-4(or5)-carboxamide, 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno](NSC-82196) (imidazole mustard) in mice and dogs
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/06/01/
VL - 30
IS - Jun
SP - 1651
EP - 1657
SN - 00085472
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-1132; Language: English; Trade Name: NSC-82196; Generic Name: Imidazole; Chemical Name: Imidazole--288-32-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents imidazole; References: 15; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2 - The physiological disposition, absorption, excretion, and metabolism of the title compound were studied in mice and dogs.
KW - Imidazole--mustard-;
KW - Absorption--imidazole--mustard, in mice and dogs;
KW - Excretion--imidazole--mustard, in mice and dogs;
KW - Metabolism--imidazole--mustard, in mice and dogs;
KW - Antineoplastic agents--imidazole--mustard, physiological disposition, in mice and dogs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DeWys, W. D.;
AU - Goldin, A.;
AU - Mantel, N.;
T1 - Hematopoietic recovery after large doses of cyclophosphamide: correlation of proliferative state with sensitivity
CT - Hematopoietic recovery after large doses of cyclophosphamide: correlation of proliferative state with sensitivity
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/06/01/
VL - 30
IS - Jun
SP - 1692
EP - 1697
SN - 00085472
AD - Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0984; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 31; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2 - This study was designed to correlate the toxic effects of cyclophosphamide on stem cells with those on bone marrow and peripheral blood cells. The results are discussed in relation to treatment intervals with the drug.
KW - Cyclophosphamide--hematopoietic recovery after large doses-;
KW - Toxicity studies--cyclophosphamide--to correlate toxic effects on stem cells with those on bone marrow and peripheral blood cells;
KW - Antineoplastic agents--cyclophosphamide--hematopoietic recovery after large doses, correlation of proliferative state with sensitivity;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - DeVita, V. T.;
T1 - Effect of chemotherapy on the growth characteristics and cellular kinetics of leukemia L1210
CT - Effect of chemotherapy on the growth characteristics and cellular kinetics of leukemia L1210
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/06/01/
VL - 30
IS - Jun
SP - 1789
EP - 1794
SN - 00085472
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2984; Language: English; References: 16; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - The double-labeling technique with thymidine-\SU/3\BS/H and -\SU/14\BS/C was used to study the in vivo effects of chemotherapy on the cell cycle and proliferation characteristics of L1210 leukemia in the ascites form. A divergent effect of carmustine and cyclophosphamide on the S phase was noted; prolongation of the S phase occurred in cells following lethal injury with carmustine but not with cyclophosphamide.
KW - Chemotherapy--effects--on growth characteristics and cellular kinetics of leukemia L1210;
KW - Antineoplastic agents--effects--of chemotherapy, on growth characteristics and cellular kinetics of leukemia L1210;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Paul, W.E.
AU - Siskind, G.W.
T1 - Hapten Specificity of Cellular Immune Responses as Compared with the Specificity of Serum Anti-hapten Antibody.
JO - Immunology
JF - Immunology
Y1 - 1970/06//
VL - 18
IS - 6
M3 - Article
SP - 921
EP - 930
SN - 00192805
AB - Comparative specificity data have been presented for the interaction of anti-hapten antibody with a series of structurally related haptens and for the stimulation by hapten-guinea pig albumin (GPA) conjugates of DNA synthesis in lymph node cell cultures from guinea pigs immunized with a given conjugate. A good correlation in the specificity of serum anti-hapten antibody and in the specificity of stimulation of DNA synthesis has been demonstrated. Thus, mutual serologic and stimulatory cross-reactivity exist between the aminocaproates and GPA conjugates of the p-iodophenysulfonyl and toluenesulfonyl groups. Poor or undetectable serologic and stimulatory cross reactivity exist in the other combinations tested. The data is consistent with the notion that the interaction of antigen with an antibody-like cellular receptor is crucial to the elicitation of cellular immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - IMMUNE response
KW - CELLULAR immunity
KW - ALBUMINS
KW - ANTIGENS
KW - IMMUNOLOGY
N1 - Accession Number: 13359421; Paul, W.E. 1; Siskind, G.W. 1; Source Information: Jun70, Vol. 18 Issue 6, p921; Subject: HAPTENS; Subject: IMMUNE response; Subject: CELLULAR immunity; Subject: ALBUMINS; Subject: ANTIGENS; Subject: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Mosimann, James E.
T1 - Size Allometry: Size and Shape Variables with Characterizations of the Lognormal and Generalized Gamma Distributions.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1970/06//
VL - 65
IS - 330
M3 - Article
SP - 930
SN - 01621459
AB - Size-related shape changes in animals are studied within a general framework of size variables and shape vectors. Isometry, or independence of shape and size, is defined as the independence of some (all) shape vector(s) from a particular size variable. With mild restrictions it is shown that isometry is possible with respect to at most one size variable, or in other words that shape will always be related to a variety of size variables. The choice of a size variable is a hitherto neglected, but important, part of an allometric study. The use of functional relationships in allometry is contrasted with the approach developed here. Also, size and shape variables are used in characterizations of the lognormal, gamma and generalized gamma distributions. The results, given in a biological context, are of interest in size and shape studies generally. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - MATHEMATICS
KW - SAMPLING (Statistics)
KW - STATISTICS
KW - ALLOMETRY
KW - SAMPLE size (Statistics)
KW - LOGNORMAL distribution
KW - VARIABLES (Mathematics)
N1 - Accession Number: 4606726; Mosimann, James E. 1; Affiliations: 1: Mathematical statistician with the National Institutes of Health.; Issue Info: Jun70, Vol. 65 Issue 330, p930; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICS; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: STATISTICS; Subject Term: ALLOMETRY; Subject Term: SAMPLE size (Statistics); Subject Term: LOGNORMAL distribution; Subject Term: VARIABLES (Mathematics); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Marshall, J. R.;
T1 - Ovulation induction
CT - Ovulation induction
JO - Obstetrics and Gynecology (USA)
JF - Obstetrics and Gynecology (USA)
Y1 - 1970/06/01/
VL - 35
IS - Jun
SP - 963
EP - 970
SN - 00297844
AD - National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, Maryland
N1 - Accession Number: 7-3894; Language: English; Chemical Name: Clomiphene--911-45-5; References: 23; Journal Coden: OBGNAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2 - Indications for ovulation induction, evaluation of patients prior to therapy and methods of treatment with clomiphene citrate and gonadotropins are discussed.
KW - Clomiphene--citrate-;
KW - Gonadotropins--ovulation induction--evaluation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lutterman, Kenneth G.
AU - Middleton, Russell
T1 - AUTHORITARIANISM, ANOMIA, AND PREJUDICE.
JO - Social Forces
JF - Social Forces
Y1 - 1970/06//
VL - 48
IS - 4
M3 - Article
SP - 485
EP - 492
SN - 00377732
AB - Previous studies of the relationship of authoritarianism and anomia to prejudice have yielded inconsistent results. This study of 1,018 college and university students finds that authoritarianism is more highly correlated to prejudice than is anomia. Possible reasons for the varying results of the studies are examined. McDill's contention that there is a common general factor-a negative world view-underlying each of the scales is rejected on the basis of a factor analysis which reveals six distinct factors, none of which accounts for more than 13.5 percent of the total variance. It is concluded that the previous studies may have been compromised by acquiescence and other response biases and that there is little profit in attempting to determine the relative importance of authoritarianism and anomia as correlates of prejudice until better measures of the variables are developed which are relatively free of response bias. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTHORITARIANISM
KW - ANOMIA
KW - PREJUDICES
KW - FACTOR analysis
KW - ANALYSIS of variance
KW - ATTITUDE (Psychology)
KW - IDEOLOGY AND ISSUES
KW - Psychological factors affecting tension
KW - Racial and ethnic aspects of tension
N1 - Accession Number: 13530506; Lutterman, Kenneth G. 1; Middleton, Russell 2; Affiliations: 1 : National Institute of Mental Health.; 2 : University of Wisconsin.; Source Info: Jun70, Vol. 48 Issue 4, p485; Subject Term: AUTHORITARIANISM; Subject Term: ANOMIA; Subject Term: PREJUDICES; Subject Term: FACTOR analysis; Subject Term: ANALYSIS of variance; Subject Term: ATTITUDE (Psychology); Author-Supplied Keyword: IDEOLOGY AND ISSUES; Author-Supplied Keyword: Psychological factors affecting tension; Author-Supplied Keyword: Racial and ethnic aspects of tension; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
TY - GEN
AU - Griggs, R. C.;
AU - Engel, W. K.;
AU - Resnick, J. S.;
T1 - Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness
CT - Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/07/01/
VL - 73
IS - Jul
SP - 39
EP - 48
SN - 00034819
AD - Medical Neurology Branch, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-3639; Language: English; Chemical Name: Acetazolamide--59-66-5; References: 30; Journal Coden: AIMEAS; Section Heading: Drug Evaluations
N2 - Although individual attacks of hypokalemic periodic paralysis are lessened by potassium treatment, recurrence is frequently not prevented by prophylactic potassium administration. Twelve patients with hypokalemic periodic paralysis were treated with acetazolamide in a placebo-controlled trial. Whereas the majority had failed to improve with previous therapy, 10 of the 12 patients were dramatically improved by acetazolamide. This response has been maintained for periods of 16 to 43 months with minimal or no side effects. Several patients previously disabled are now asymptomatic. In addition to eliminating attacks of weakness, acetazolamide also improved interattack weakness in 8 of 10 affected patients. The mechanism of effect of acetazolamide was not discovered. Acetazolamide produced a mild metabolic acidosis but did not have a demonstrable effect on total body sodium, total body potassium, or thyroid function. Acetazolamide is the most effective treatment available for hypokalemic periodic paralysis.
KW - Acetazolamide--hypokalemic periodic paralysis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pearson, J. W.;
AU - Gibson, W. T.;
AU - Chirigos, M. A.;
T1 - Use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents
CT - Use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/07/01/
VL - 30
IS - Jul
SP - 2024
EP - 2028
SN - 00085472
AD - Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0715; Language: English; Chemical Name: Melphalan--148-82-3 Carmustine--154-93-8; Therapeutic Class: (8:18); AHFS Class: Virucides melphalan (8:18); AHFS Class: Virucides carmustine; References: 9; Journal Coden: CNREA8; Section Heading: Microbiology; Investigational Drugs
N2 - A variant of the murine sarcoma virus (Moloney) was used as a model for evaluating potential antiviral agents. Two drugs, melphalan, and carmustine, were tested for antiviral activity against a plasma variant of the murine sarcoma virus. The parameters utilized for drug effectiveness were retardation of splenomegaly and inhibition of virus synthesis in the drug-treated host animals. Both drugs were found to be effective.
KW - Melphalan--activity-;
KW - Carmustine--activity-;
KW - Virucides--melphalan--activity, against plasma variant of murine sarcoma virus, in animals;
KW - Virucides--carmustine--activity, against plasma variant of murine sarcoma virus, in animals;
KW - Methodology--drug screening--variant of murine sarcoma virus used for evaluating potential antiviral agents;
KW - Drugs--evaluations--variant of murine sarcoma virus used for evaluating potential antiviral agents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Waalkes, T. P.;
AU - Denham, C.;
AU - DeVita, V. T.;
T1 - Pentamidine: clinical pharmacologic correlations in man and mice
CT - Pentamidine: clinical pharmacologic correlations in man and mice
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/07/01/
VL - 11
IS - Jul-Aug
SP - 505
EP - 512
SN - 00099236
AD - The Human Tumor Cell Biology Branch and the Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-0803; Language: English; Chemical Name: Pentamidine--100-33-4; Therapeutic Class: (8:00); AHFS Class: Antiprotozoals pentamidine; References: 25; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2 - Patients with malignant disease complicated by diffuse interstitial pneumonia due to proved or suspected Pneumocystis carinii were given pentamidine in the dosage schedule recommended for this infection. By means of a sensitive method of assay, the plasma levels and urinary excretion of pentamidine during therapy were studied in these patients. Following the intramuscular administration of pentamidine, plasma levels were low and urinary excretion prolonged. After a single intraperitoneal injection in mice, the tissue distribution levels and excretion pattern for pentamidine were determined at various time intervals. There was storage of the drug in tissues and excretion was delayed. The highest concentration of pentamidine was found in the kidney. In mice pentamidine is eliminated primarily intact with little, if any, altered. The available data in man also suggested that pentamidine is retained, bound to tissues, and excreted over an extended period. Although renal abnormalities followed pentamidine, it was not possible to implicate the drug in all cases because of the seriousness of the illness and the concomitant use of other drugs. Pentamidine is useful in preventing disease due to \IT/Trypanosoma gambiense \OK/as well as effective in the treatment of diffuse interstitial pneumonia due to \IT/Pneumocystis carinii\OK/. The frequency of this type of pneumonia in cancer patients and in patients undergoing organ transplantation suggests the need for studies in animals and man.
KW - Pentamidine--prevention-;
KW - Antiprotozoals--pentamidine--prevention of interstitial pneumonia due to Pneumocystis carinii in patients with malignant disease, prevention of disease due to Trypanosoma gambiense;
KW - Metabolism--pentamidine--in man and mice;
KW - Drugs, body distribution--pentamidine--in man and mice;
KW - Excretion--pentamidine--in man and mice;
KW - Blood levels--pentamidine--in man and mice;
KW - Tissue levels--pentamidine--in man and mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rao, G. S.;
T1 - Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine
CT - Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine
JO - Journal of Pharmacy and Pharmacology (England)
JF - Journal of Pharmacy and Pharmacology (England)
Y1 - 1970/07/01/
VL - 22
IS - Jul
SP - 544
EP - 545
SN - 03731022
AD - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2864; Language: English; Trade Name: Peyocactin; Generic Name: Hordenine; Chemical Name: Hordenine--539-15-1; Therapeutic Class: (8:12); AHFS Class: Antibiotics hordenine; References: 9; Publication Type: Letters; Journal Coden: JPPMAB; Section Heading: Pharmaceutical Chemistry; Pharmacognosy; Abstract Author: Douglas L. Thompson
N2 - Based on data from the proton magnetic resonance spectrum, the mass spectrum of peyocactin was identified as N,N-dimethyl-p-hydroxyphenethylamine (hordenine). Furthermore, the IR spectra of peyocactin sulfate and hordenine sulfate were superimposable and their m.p. (197-198\DG/) was unaltered upon admixture.
KW - Hordenine--analysis-;
KW - Antibiotics--hordenine--identical to peyocactin;
KW - Lophophora williamsii--peyocactin--constituents, identical to hordenine;
KW - Analysis--peyocactin--constituents, L. williamsii, identical to hordenine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chanock, R. M.;
T1 - Control of acute mycoplasmal and viral respiratory tract disease
CT - Control of acute mycoplasmal and viral respiratory tract disease
JO - Science
JF - Science
Y1 - 1970/07/17/
VL - 169
IS - Jul 17
SP - 248
EP - 256
AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1 - Accession Number: 8-0216; Language: English; References: 81; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Robert A. Hall
N2 - The difficulties of design, immunological determinants of resistance and an evaluation of some vaccines for the control of acute mycoplasmal and viral respiratory tract disease are discussed in this review article. The prospects of eventual successful immunoprophylaxis through vaccination are reputedly encouraging.
KW - Vaccines--acute mycoplasmal and viral respiratory tract disease--discussion;
KW - Diseases--acute mycoplasmal and viral respiratory tract--vaccines;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Burbank, F.;
AU - Fraumeni, J. F., Jr.;
T1 - Synthetic sweetener consumption and bladder cancer trends in the United States
CT - Synthetic sweetener consumption and bladder cancer trends in the United States
JO - Nature (London)
JF - Nature (London)
Y1 - 1970/07/18/
VL - 227
IS - Jul 18
SP - 296
EP - 297
AD - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-1652; Language: English; References: 9; Journal Coden: NATUAS; Human Indicator: Yes; Section Heading: Toxicity; Sociology, Economics and Ethics; Abstract Author: Robert Alan Hall
N2 - Consumption patterns of cyclamates and the trends for bladder cancer in the United States are examined. Consumption of cyclamates increased from 2.7 million pounds in 1962 to 19.7 million pounds in 1969. Although there are differences in death rates for bladder cancer by race and sex, no clear cut break in either age specific or age adjusted rates has occurred since 1962. Incidence rates for bladder cancer from 2 states indicate a slow long-term increase; however, the increase may be due to another factor which increases the neoplasm: cigarette smoking.
KW - Sweetening agents--cyclamates--carcinogenicity, consumption and bladder cancer trends, in U.S.;
KW - Carcinogenicity--cyclamates--consumption patterns and bladder cancer trends, in U.S.;
KW - Toxicity--cyclamates--carcinogenicity, consumption patterns and trends for bladder cancer, in U.S.;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Neva, F. A.;
AU - Sheagren, J. N.;
AU - Shulman, N. R.;
AU - Canfield, C. J.;
T1 - Malaria: host-defense mechanisms and complications
CT - Malaria: host-defense mechanisms and complications
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/08/01/
VL - 73
IS - Aug
SP - 295
EP - 306
SN - 00034819
AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3638; Language: English; Trade Name: Diaminodiphenylsulfone; Generic Name: Dapsone; Chemical Name: Chloroquine--54-05-7 Quinine--130-95-0 Pyrimethamine--58-14-0 Dapsone--80-08-0; References: 46; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Judith A. Kepler
N2 - The host-defense mechanisms and complications of malaria and the present status of chemotherapy of falciparum infections are reviewed. Response to various treatment regimens using the following drugs is discussed: chloroquine, quinine, pyrimethamine, various sulfonamides, and diaminodiphenylsulfone (dapsone).
KW - Chloroquine--malaria-;
KW - Quinine--malaria-;
KW - Pyrimethamine--malaria-;
KW - Dapsone--malaria-;
KW - Malaria--therapy--host-defense mechanisms and complications, present status of chemotherapy;
KW - Sulfonamides--malaria--therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gottlieb, J. A.;
AU - Serpick, A. A.;
T1 - Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors
CT - Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/08/01/
VL - 30
IS - Aug
SP - 2132
EP - 2138
SN - 00085472
AD - Medical Service, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211
N1 - Accession Number: 8-0583; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 21; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - This article reports the use of methotrexate in the treatment of acute leukemia and of solid tumors including those of the testis. Five patients with previously treated acute leukemia received 14 courses of a 24-hour I.V. infusion of a 2 mg./kg. dose of methotrexate followed by 6 mg. of leucovorin. Four additional leukemia patients, previously treated, and 10 other patients with various metastatic solid tumors, largely choriogonadotropin-producing testicular tumors, received 24 courses of methotrexate at 5 mg./kg., with 60% given as a rapid I.V. injection, followed by the remaining 40% given as a 4-hour infusion. The last regimen was repeated on 2 consecutive days, and no leucovorin was given. Courses were generally repeated at 2-week intervals. Two of the 8 evaluable choriogonadotropin-producing tumors had complete remissions lasting 3 months and 18+ months. Four others responded solely with a decrease in urinary gonadotropin levels, while 2 more exhibited small decreases in the size of metastatic lesions. No complete remissions were seen in the leukemic patients, although marked decreases in the number of peripheral and bone marrow blasts were almost always observed. Two elderly leukemia patients tolerated the 24-hour infusions exceptionally well. No response was seen in a patient with squamous cell carcinoma of the lung.
KW - Methotrexate--therapy-;
KW - Antineoplastic agents--methotrexate--therapy, of acute leukemia and of solid tumors;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Abelson, H. T.;
AU - Rabstein, L. S.;
T1 - Influence of prednisolone on Moloney leukemogenic virus in BALB/\LC/c\UC/ mice
CT - Influence of prednisolone on Moloney leukemogenic virus in BALB/\LC/c\UC/ mice
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/08/01/
VL - 30
IS - Aug
SP - 2208
EP - 2212
SN - 00085472
AD - Laboratory of Viral Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-3101; Language: English; Chemical Name: Prednisolone--50-24-8; References: 35; Journal Coden: CNREA8; Section Heading: Toxicity
N2 - This paper reports efforts to influence the outcome of Moloney leukemia virus infection in BALB/c mice by the long-term administration of prednisolone. Long-term administration of prednisolone to BALB/c mice alters the reactivity of their lymphoid tissue to the oncogenic effects of Moloney leukemia virus. Solid lymphosarcoma or granulocytic leukemia is produced in a significant number of the treated mice. The alteration in disease response may be attributed to a prednisolone-induced simulated thymectomy.
KW - Prednisolone--effects-;
KW - Toxicity--prednisolone--effects, on Moloney leukemogenic virus, in mice, long-term administration;
KW - Carcinogens--prednisolone--effects, on Moloney leukemogenic virus, in mice, long-term administration;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06132-005
AN - 2006-06132-005
AU - Yarrow, Leon J.
T1 - Ethology, Control Systems, Psychoanalysis and Mother Love.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1970/08//
VL - 15
IS - 8
SP - 493
EP - 494
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06132-005. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Attachment Behavior; Mother Child Communication; Mother Child Relations; Psychoanalysis. Minor Descriptor: Love; Mothers; Psychoanalytic Theory. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Bowlby, John. Attachment and Loss: Vol. I: Attachment=New York: Basic Books, 1969. Pp. xx + 428. $8.50; 1969. Page Count: 2. Issue Publication Date: Aug, 1970.
AB - Reviews the book, Attachment and Loss: Vol. I: Attachment by John Bowlby (1969). In this volume the author takes a dispassionate view of the mother-child attachment and analyzes its roots. His views on the development of the bond between mother and child have been evolving over the past twenty years. The task that author has set for himself, the integration of these diverse themes into a coherent theory of the origins of attachment, is clearly a prodigious intellectual feat. The basic concepts of each theoretical position are developed with great clarity, and there is an orderly systematic progression of ideas; but when the author attempts to blend the components, he is not so successful. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mother child relationship
KW - mother child attachment
KW - mother love
KW - psychoanalysis
KW - 1970
KW - Attachment Behavior
KW - Mother Child Communication
KW - Mother Child Relations
KW - Psychoanalysis
KW - Love
KW - Mothers
KW - Psychoanalytic Theory
KW - 1970
U2 - Bowlby, John. (1969); Attachment and Loss: Vol. I: Attachment; New York: Basic Books, 1969. Pp. xx + 428. $8.50
DO - 10.1037/013813
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06132-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06132-012
AN - 2006-06132-012
AU - Senders, Virginia L.
T1 - Right But Trite.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1970/08//
VL - 15
IS - 8
SP - 505
EP - 506
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06132-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Senders, Virginia L.; National Institute of Mental Health, McLean Hospital, Belmont, MA, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Females; Middle Class; Mothers; Values. Minor Descriptor: Messages; Trends. Classification: Sex Roles & Women's Issues (2970). Population: Human (10). Reviewed Item: Harbeson, Gladys E. Choice and Challenge for the American Woman=Cambridge, Mass.: Schenkman, 1967. Pp. xvii + 185. $7.95; 1967. Page Count: 2. Issue Publication Date: Aug, 1970.
AB - Reviews the book, Choice and Challenge for the American Woman by Gladys E. Harbeson (see record [rid]1969-14176-000[/rid]). The author wrote the book, she says, because she felt that information about changing trends in women's lives should be made available to a wider range of readers than had previously received it, and she hoped to present 'suggestions for formulating a theory of values which could assist the individual in her adaptation to the new patterns.' Despite its title, the book's message is limited to upper-middle-class, educated women. The author should not be criticized for this limitation, but it is harder to understand her failure to discuss the effects on women's lives of population explosion, with its implied devaluation of the mother's role, or information explosion, with its accompaniment of rapid professional obsolescence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American woman
KW - women lives
KW - theory of values
KW - choice and challenge
KW - 1970
KW - Human Females
KW - Middle Class
KW - Mothers
KW - Values
KW - Messages
KW - Trends
KW - 1970
U2 - Harbeson, Gladys E. (1967); Choice and Challenge for the American Woman; Cambridge, Mass.: Schenkman, 1967. Pp. xvii + 185. $7.95
DO - 10.1037/013820
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06132-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Brown, C. H., III;
AU - Canellos, G. P.;
AU - Carbone, P. P.;
T1 - Effect of L-asparaginase on mouse bone marrow, assayed by in vitro culture
CT - Effect of L-asparaginase on mouse bone marrow, assayed by in vitro culture
JO - Blood
JF - Blood
Y1 - 1970/09/01/
VL - 36
IS - Sep
SP - 385
EP - 389
AD - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-3889; Language: English; Chemical Name: Asparaginase--9015-68-3; References: 13; Journal Coden: BLOOAW; Section Heading: Pharmacology; Abstract Author: Jimmie L. Hall
N2 - The effect of asparaginase on mouse hemopoietic cell function was examined. Asparaginase was administered to mice in doses of 10, 100, 1000 or 10,000 I.U. per kg., and the bone marrow was cultured 4 or 24 hours later. Marrow cellularity and the number of in vitro colony forming units were reduced with all doses at 4 hours. Only the highest dose, however, resulted in any suppression at 24 hours. These results suggest that normal bone marrow cells can adapt to the L-asparagine depletion induced by L-asparaginase.
KW - Asparaginase--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Shapiro, W. R.;
AU - Ausman, J. I.;
AU - Rall, D. P.;
T1 - Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea, cyclophosphamide, mithramycin, and methotrexate
CT - Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea, cyclophosphamide, mithramycin, and methotrexate
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/09/01/
VL - 30
IS - Sep
SP - 2401
EP - 2413
SN - 00085472
AD - Office of the Associate Scientific Director for Experimental Therapeutics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-1110; Language: English; Trade Name: Urea; Generic Name: Carmustine; Chemical Name: Carmustine--154-93-8 Cyclophosphamide--6055-19-2 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents mithramycin (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 50; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2 - The antineoplastic effects of carmustine, cyclophosphamide, mithramycin, and methotrexate were determined in mice with implanted carcinogen-induced gliomas. Carmustine significantly prolonged the life span of the mice. Cyclophosphamide was less effective, while mithramycin and methotrexate had no observable effect. The implications of these results with respect to blood-brain barrier, brain tumor permeability, and the value of the model as a screen for human brain tumor chemotherapy are discussed.
KW - Carmustine--effects-;
KW - Cyclophosphamide--effects-;
KW - Mithramycin--effects-;
KW - Methotrexate--effects-;
KW - Antineoplastic agents--carmustine--effects, in mice with implanted carcinogen-induced gliomas;
KW - Antineoplastic agents--cyclophosphamide--effects, in mice with implanted carcinogen-induced gliomas;
KW - Antineoplastic agents--mithramycin--effects, lack, in mice with implanted carcinogen-induced gliomas;
KW - Antineoplastic agents--methotrexate--effects, lack, in mice with implanted carcinogen-induced gliomas;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1110&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Watanabe, A. M.;
AU - Chase, T. N.;
AU - Cardon, P. V.;
T1 - Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes
CT - Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/09/01/
VL - 11
IS - Sep-Oct
SP - 740
EP - 746
SN - 00099236
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 8-1663; Language: English; Trade Name: Dopa; Generic Name: Levodopa; Chemical Name: Levodopa--59-92-7; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2 - L-Dopa (levodopa) produced a significant reduction in recumbent and standing blood pressure in patients with neurologic or psychiatric disorders. The addition of an extracerebral decarboxylase inhibitor potentiated this effect. Reflex forearm arteriolar and venous constriction was present during therapy with L-dopa alone or in combination with the decarboxylase inhibitor, but there was an attenuation of reflex forearm arteriolar constriction. It is suggested that the hypotensive effect of L-dopa may be mediated through the central nervous system.
KW - Levodopa--effects-;
KW - Drug interactions--levodopa--effects, alone and combined with extracerebral decarboxylase inhibitor, on blood pressure and cardiovascular reflexes;
KW - Enzyme inhibitors--decarboxylase inhibitor--and levodopa, effects on blood pressure and cardiovascular reflexes;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1663&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lancaster, F. W.
AU - Jenkins, Grace T.
T1 - u Quality Control" Applied to the Operations of a Large Information System.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1970/09//Sep/Oct1970
VL - 21
IS - 5
M3 - Article
SP - 370
EP - 371
SN - 00028231
AB - The recent evaluation of Medlars has shown that it is possible to undertake an investigation to measure the effectiveness of a large mechanized retrieval system and to identify the factors that are most important in controlling and limiting the effectiveness of the system. A one-time evaluation, however, can only measure the performance of a system at a particular point in time. When changes are made to the system, as a result of the investigation, we would like to be able to estimate the effects of those changes. Moreover, a one-time evaluation, however comprehensive, cannot identify all sources of system failure. It can locate the most important sources and the areas of greatest weakness, but it cannot identify, for example, all specific instances of vocabulary inadequacy in the system.
KW - INFORMATION storage & retrieval systems
KW - QUALITY control
KW - FACTORY management
KW - MEDLARS
KW - MEDICINE
KW - WEIGHTS & measures
N1 - Accession Number: 16748114; Lancaster, F. W. 1; Jenkins, Grace T. 2; Affiliations: 1: Graduate School of Library Science University of Illinois Urbana, Illinois.; 2: Bibliographic Services Division National Library of Medicine National Institutes of Health Bethesda, Maryland.; Issue Info: Sep/Oct1970, Vol. 21 Issue 5, p370; Thesaurus Term: INFORMATION storage & retrieval systems; Thesaurus Term: QUALITY control; Thesaurus Term: FACTORY management; Subject Term: MEDLARS; Subject Term: MEDICINE; Subject Term: WEIGHTS & measures; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=16748114&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2009-11543-003
AN - 2009-11543-003
AU - Katz, Martin M.
AU - Sanborn, Kenneth O.
AU - Gudeman, Howard
T1 - Characterizing differences in psychopathology among ethnic groups in Hawaii.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1970///Fal 1970
VL - 1
IS - 2
SP - 20
EP - 29
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11543-003. Partial author list: First Author & Affiliation: Katz, Martin M.; Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Association for Research on Mental and Nervous Diseases, Dec, 1967, New York, NY, US. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Psychopathology; Psychosis; Racial and Ethnic Differences. Minor Descriptor: Hospitalized Patients. Classification: Psychological Disorders (3210). Population: Human (10); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Mental Status Schedule; Inpatient Multidimensional Psychiatric Rating Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Fal 1970.
AB - The most general aim of this research, as a comparative study in culture and psychopathology, is the establishing of valid, objective pictures of the psychopathology of particular ethnic groups. Specifically, there is interest in (1) whether various ethnic groups, in this case Hawaii-Japanese, Hawaii-Filipinos, Hawaii-Caucasians, and Part-Hawaiians, manifest functional psychosis differently; (2) whether these differences are consistent with those found in previous studies or with what might be expected from an understanding of normal personality in these ethnic groups; (3) whether these differences are consistent across different settings (i.e., will the differences which appear in their social behavior and symptomatology in the community be the same as those which appear when they are in the hospital?); and (4) whether there are ways in which all these groups of functional psychotics are the same. The study sample of patients represented all admissions to Hawaii State Hospital for functional disorders, excluding alcoholics, between the ages of 20 and 50 during a given year. The psychopathology of each patient was to be studied both in the community and in the hospital. For purposes of this presentation, the results of the comparison of the Japanese and the Caucasians will be briefly summarized as a means of demonstrating how we go about attempting to establish valid pictures of the psychopathology of the various ethnic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathology
KW - Hawaiian ethnic groups
KW - ethnic differences
KW - psychosis
KW - community settings
KW - hospital settings
KW - 1970
KW - Psychopathology
KW - Psychosis
KW - Racial and Ethnic Differences
KW - Hospitalized Patients
KW - 1970
DO - 10.1093/schbul/1.2.20
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11543-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Katz, E.;
AU - Grimley, P.;
AU - Moss, B.;
T1 - Reversal of antiviral effects of rifampicin
CT - Reversal of antiviral effects of rifampicin
JO - Nature (London)
JF - Nature (London)
Y1 - 1970/09/05/
VL - 227
IS - Sep 5
SP - 1050
EP - 1051
AD - National Institute of Allergy and Infectious Diseases, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 9-2647; Language: English; Trade Name: Rifampicin; Generic Name: Rifampin; Chemical Name: Rifampin--13292-46-1; Therapeutic Class: (8:18); AHFS Class: Virucides rifampin; References: 14; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: Robert Alan Hall
N2 - The sequence of events following removal of rifampicin (rifampin) is examined to correlate effects observed on formation of late particulate RNA polymerase activity and on the assembly of viral envelopes. Rifampicin treated HeLa cells were infected with vaccina virus. After 8 hours the drug was removed. The cells were resuspended in warm medium and samples removed at intervals were examined by electron microscopy. Late particulate RNA polymerase activity could not be demonstrated until after the rifampicin effect on the formation of the viral envelope was completely reversed.
KW - Rifampin--effects-;
KW - Virucides--rifampin--effects, antiviral, reversal;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-2647&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Van Thiel, D. H.;
AU - Ross, G. T.;
AU - Lipsett, M. B.;
T1 - Pregnancies after chemotherapy of trophoblastic neoplasms
CT - Pregnancies after chemotherapy of trophoblastic neoplasms
JO - Science
JF - Science
Y1 - 1970/09/25/
VL - 169
IS - Sep 25
SP - 1326
EP - 1327
AD - National Cancer Institute, National Institues of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2573; Language: English; Chemical Name: Methotrexate--59-05-2 Dactinomycin--50-76-0 Vinblastine--865-21-4 Mechlorethamine--51-75-2 Norleucine--327-57-1; References: 13; Journal Coden: SCIEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Robert A. Hall
N2 - Eighty-eight pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents were examined. Cytotoxic agents used singly or in combinations were: methotrexate, actinomycin-D (dactinomycin), vinblastine, nitrogen mustard (mechlorethamine) and 6-diazo-norleucine. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.
KW - Methotrexate--toxicity-;
KW - Dactinomycin--toxicity-;
KW - Vinblastine--toxicity-;
KW - Mechlorethamine--toxicity-;
KW - Norleucine--6-diazo--;
KW - Toxicity--antineoplastic agents--lack, on subsequent pregnancies, in women;
KW - Antineoplastic agents--toxicity--lack, on subsequent pregnancies, in women;
KW - Teratogenicity--antineoplastic agents--lack, in pregnant women previously treated for gestational trophoblastic neoplasms;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-2573&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Aronoff, M. S.;
AU - Epstein, R. S.;
T1 - Factors associated with poor response to lithium carbonate: a clinical study
CT - Factors associated with poor response to lithium carbonate: a clinical study
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1970/10/01/
VL - 127
IS - Oct
SP - 472
EP - 480
SN - 0002953X
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Chevy Chase, Maryland
N1 - Accession Number: 8-0826; Language: English; Chemical Name: Lithium carbonate--554-13-2 Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 24; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - The characteristics of manic patients who have had a poor or irregular response to lithium therapy is presented. Eighteen patients with intermittent manic illness were treated with lithium on a regular basis for an average of 2 years. Lithium salts appear to predictably and reversibly alter mood state at blood levels that cause no general sedation or tranquilization, unlike the phenothiazines. The effectiveness of the lithium ion in the treatment of acute and recurrent manic illness has been well established by several double-blind studies and by 20 years of clinical experience. These studies, however, report a poor response to lithium in 20 to 40% of patients treated for mania. Because of the interest in lithium as a research tool in the study of affective illness, it is important to determine why this ion is not always therapeutically effective.
KW - Lithium carbonate--mania-;
KW - Lithium--mania-;
KW - Psychotherapeutic agents--lithium carbonate--mania, therapy, characteristics of patients with poor or irregular response;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0826&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fales, H. M.;
AU - Milne, G. W. A.;
AU - Axenrod, T.;
T1 - Identification of barbiturates by chemical ionization mass spectrometry
CT - Identification of barbiturates by chemical ionization mass spectrometry
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1970/10/01/
VL - 42
IS - Oct
SP - 1432
EP - 1435
AD - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 7-4179; Language: English; Trade Name: Nembutal--Seconal--Amytal--Phanlodorn--Ortal--Alurate; Generic Name: Pentobarbital; Secobarbital; Amobarbital; Cyclobarbital; Hexethal; Aprobarbital; Chemical Name: Pentobarbital--76-74-4 Phenobarbital--50-06-6 Amobarbital--57-43-2 Cyclobarbital--52-31-3 Secobarbital--76-73-3 Butalbital--77-26-9 Aprobarbital--77-02-1; References: 13; Journal Coden: ANCHAM; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The electron impact and chemical ionization mass spectra of the following 8 barbiturates were studied; aprobarbital, secobarbital (Seconal), butalbital (Alurate), pentobarbital (Nembutal), hexethal (Ortal), phenobarbital, amobarbital (Amytal) and cyclobarbital (Phanlodorn.) It was concluded that, because of the very large cross section for proton capture possessed by the barbituric acid nucleus, quasimolecular ions derived from barbiturates in chemical ionization mass spectrometry are very intense and can be used to help identify the specific barbiturates. The value of this method in an actual case of drug identification has been demonstrated.
KW - Pentobarbital--analysis-;
KW - Hexethal--analysis-;
KW - Phenobarbital--analysis-;
KW - Amobarbital--analysis-;
KW - Cyclobarbital--analysis-;
KW - Secobarbital--analysis-;
KW - Butalbital--analysis-;
KW - Aprobarbital--analysis-;
KW - Analysis--barbiturates--chemical ionization mass spectrometry;
KW - Barbiturates--analysis--chemical ionization mass spectrometry;
KW - Spectrometry--mass--chemical ionization, identification of barbiturates;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4179&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bennett, J. E.;
T1 - Clotrimazole: new drug for systemic mycoses?
CT - Clotrimazole: new drug for systemic mycoses?
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/10/01/
VL - 73
IS - Oct
SP - 653
EP - 654
SN - 00034819
AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 7-4569; Language: English; Chemical Name: Clotrimazole--23593-75-1; Therapeutic Class: (8:12.04); AHFS Class: Fungicides clotrimazole; References: 5; Publication Type: Editorial Notes; Journal Coden: AIMEAS; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Judith A. Kepler
N2 - A critical review of the data on clotrimazole, a new antifungal agent, is presented.
KW - Clotrimazole--fungicide-;
KW - Fungicides--clotrimazole--discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4569&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
AU - Murphy, D. L.;
AU - Brodie, H. K. H.;
AU - Bunney, W. E., Jr.;
T1 - L-Dopa, catecholamines, and behavior: a clinical and biochemical study in depressed patients
CT - L-Dopa, catecholamines, and behavior: a clinical and biochemical study in depressed patients
JO - Biol. Psychiatry
JF - Biol. Psychiatry
Y1 - 1970/10/01/
VL - 2
IS - Oct
SP - 341
EP - 363
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 8-0885; Language: English; Chemical Name: Levodopa--59-92-7; References: 76; Journal Coden: BIPCBF; Human Indicator: Yes; Section Heading: Pharmacology
N2 - L-Dopa (levodopa) was administered in large oral doses to 16 depressed patients under double-blind conditions to evaluate the possible effects of this catecholamine precursor on mood and behavior. The dosages used were equivalent to those which produce behavioral effects and brain amine changes in animals, as well as being equal to those recently found to be therapeutic in Parkinson's disease. Changes in cerebrospinal fluid and urinary catecholamine and indoleamine metabolites, and in cortical evoked potential measurements provide suggestive evidence that L-dopa altered catecholamines both in brain and the periphery. The consistent induction of hypomania or mania in all 5 of the depressed patients who had prior histories of mania suggests that catecholamines, especially dopamine, may be directly involved in the genesis, or triggering, of manic behavior in susceptible individuals.
KW - Levodopa--effects-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0885&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levin, V. A.;
AU - Shapiro, W. R.;
AU - Clancy, T. P.;
AU - Oliverio, V. T.;
T1 - Uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma
CT - Uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/10/01/
VL - 30
IS - Oct
SP - 2451
EP - 2455
SN - 00085472
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-1109; Language: English; Chemical Name: Urea--57-13-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents urea; References: 17; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2 - The purposes of this experiment were to determine in mice the tumor and brain distribution of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and to test its antineoplastic activity against implanted brain tumors. Uptake and distribution studies indicate that CCNU has relatively constant tissue/plasma ratio levels. The life-span of tumor-bearing animals was increased by CCNU from 2- to 4-fold, depending on the dose used and the type of tumor. Although few conclusions can be made regarding the mode of action of CCNU, further consideration of its use in the treatment of human gliomas seems warranted.
KW - Urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso--;
KW - Antineoplastic agents--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, absorption, distribution, and activity, in the murine glioma;
KW - Absorption--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW - Drugs, body distribution--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW - Metabolism--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, absorption, distribution, and antineoplastic activity, in the murine gioma;
KW - Tissue levels--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
KW - Blood levels--urea--1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-, in mice with implanted brain tumors;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1109&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bonadonna, G.;
AU - Monfardini, S.;
AU - De Lena, M.;
AU - Fossati-Bellani, F.;
AU - Beretta, G.;
T1 - Phase I and preliminary phase II evaluation of adriamycin (NSC-123127)
CT - Phase I and preliminary phase II evaluation of adriamycin (NSC-123127)
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/10/01/
VL - 30
IS - Oct
SP - 2572
EP - 2582
SN - 00085472
AD - reprints: Instituto Nazionale dei Tumori, Via Venezian, 1, 20133, Italy
AD - The Clinical Chemotherapy Unit, National Cancer Institute, Milan, Italy
N1 - Accession Number: 8-0994; Language: English; Trade Name: NSC-123127; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 22; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Jimmie L. Hall
N2 - This article describes a phase I and early phase II evaluation of the antineoplastic effects of adriamycin in 155 patients with various types of neoplastic disease. Adriamycin was administered in a rapid, single I.V. injection at doses of 0.4, 0.65, or 0.8 mg./kg. It was also sometimes given intrapleurally or intra-arterially. Appreciable responses were seen in acute lymphoblastic leukemia, chronic myeloid leukemia, neuroblastoma, Ewing's sarcoma, seminoma, soft tissue sarcomas, and various types of malignant lymphomas. However, complete remission was observed in only a few cases despite the fact that tumor regression started after only a few doses. Toxicity consisted primarily of stomatitis, bone marrow depression, and alopecia. The results indicate that adriamycin is active in many forms of neoplastic disease, and that it is more useful in inducing regressions than as maintenance therapy.
KW - Doxorubicin--neoplastic diseases-;
KW - Antineoplastic agents--doxorubicin--neoplastic diseases, phase I and preliminary phase II evaluation;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0994&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Joseph, W. L.;
AU - Melewicz, F.;
AU - Morton, D. L.;
T1 - Spontaneous development of mammary adenocarcinoma following prolonged immunosuppression in the dog
CT - Spontaneous development of mammary adenocarcinoma following prolonged immunosuppression in the dog
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1970/10/01/
VL - 30
IS - Oct
SP - 2606
EP - 2608
SN - 00085472
AD - Tumor Immunology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-3546; Language: English; Chemical Name: Azathioprine--446-86-6 Methylprednisolone--83-43-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents azathioprine (92:00); AHFS Class: Immunosuppressive agents methylprednisolone; References: 8; Journal Coden: CNREA8; Section Heading: Toxicity; Abstract Author: Jimmie L. Hall
N2 - This communication reports the apparent spontaneous development in a laboratory animal of a mammary adenocarcinoma while being treated with immunosuppressants. An adult female mongrel dog developed the tumors while on a regimen of azathioprine and methylprednisolone.
KW - Azathioprine--and methylprednisolone-;
KW - Methylprednisolone--and azathioprine-;
KW - Immunosuppressive agents--azathioprine--and methylprednisolone, mammary adenocarcinoma following prolonged immunosuppression, in dog;
KW - Immunosuppressive agents--methylprednisolone--and azathioprine, mammary adenocarcinoma following prolonged immunosuppression, in dog;
KW - Toxicity--azathioprine--and methylprednisolone, mammary adenocarcinoma following prolonged immunosuppression, in dog;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3546&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
AU - Peel, L. F.
T1 - Antibody Production in the Bullfrog (Rana catesbeiana.
JO - Immunology
JF - Immunology
Y1 - 1970/10//
VL - 19
IS - 4
M3 - Article
SP - 539
EP - 550
SN - 00192805
AB - Serum antibody was found by radioimmunoelectrophoresis (RIEP) in thirty-one of thirty-five bullfrogs (BF) immunized with one of four protein antigens. Rabbit γ globulin (RGG) and hen egg albumin were the best antigens, whereas human serum albumin and bovine serum albumin induced a less consistent immune response. Although a IgM to IgG sequence of antibody production usually was detected with RGG as antigen, a similar sequence was infrequent with the other antigens and the initial response was usually a IgG antibody. IgM antibody was detected in the serum for a prolonged interval (>100 days) and precipitating quantities of IgG antibody were found more than 1 year after antigen inoculation. As measured by haemagglutination, the IgM antibody was routinely inactivated by mercaptoethanol (ME) treatment and IgG antibody was frequently inactivated by ME, although it still had antigen binding capacity by RIEP. IgG hemagglutinins, which were resistant to ME treatment, were found in some sera obtained from BF after booster injections of antigen. Immunoelectrophoretic examination of normal or immune BF sera revealed a prominent precipitin line of slow γ-mobility which did not bind 131I-labelled antigen but did bind 59Fe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - BULLFROG
KW - ANTIGENS
KW - PRECIPITIN reaction
KW - IMMUNITY
KW - ADMINISTRATION of drugs
N1 - Accession Number: 13360207; Coe, J.E. 1; Peel, L. F. 1; Source Information: Oct70, Vol. 19 Issue 4, p539; Subject: IMMUNOGLOBULINS; Subject: BULLFROG; Subject: ANTIGENS; Subject: PRECIPITIN reaction; Subject: IMMUNITY; Subject: ADMINISTRATION of drugs; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Knorr, D. W. R.;
AU - Kirschner, M. A.;
AU - Taylor, J. P.;
T1 - Estimation of estrone and estradiol in low level urines using electron-capture gas-liquid chromatography
CT - Estimation of estrone and estradiol in low level urines using electron-capture gas-liquid chromatography
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1970/10/01/
VL - 31
IS - Oct
SP - 409
EP - 416
AD - reprints: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, New Jersey 07112
AD - Endocrinology Branch, National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 8-0926; Language: English; Chemical Name: Estrone--53-16-7 Estradiol--50-28-2; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
KW - Estrone--and estradiol-;
KW - Estradiol--and estrone-;
KW - Metabolism--estrone--analysis, in urine;
KW - Metabolism--estradiol--analysis, in urine;
KW - Chromatography, gas--estrogens--urinalysis of estrone and estradiol;
KW - Estrogens--chromatography, gas--urinalysis of estrone and estradiol;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-40706-020
AN - 2013-40706-020
AU - Torrey, E. Fuller
T1 - Review of Teaching as a subversive activity.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1970/10//
VL - 40
IS - 5
SP - 885
EP - 886
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40706-020. Partial author list: First Author & Affiliation: Torrey, E. Fuller; Div. of Manpower & Training, National Institute of Mental Health, Chevy Chase, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Curriculum; Education; Teaching. Minor Descriptor: Mental Health Personnel. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Reviewed Item: Postman, Neil; Weingartner, Charles. Teaching as a subversive activity=New York: Delacorte Press. 218 pp. $5.95; 1969. Page Count: 2. Issue Publication Date: Oct, 1970.
AB - Reviews the book, Teaching as a Subversive Activity by Neil Postman and Charles Weingartner (1969). Any mental health worker concerned with the institution of education should read this book. It describes vividly the wasteland that we put under that label and the bleak process whereby we produce 'intellectual paraplegics.' The book is more than a critique of education, however. It suggests as a paradigm that we use the student as the starting point, rather than some theoretical body of truth. The authors also attack the content of the current curriculum, which they maintain 'is largely designed to keep students from knowing themselves and their environment in any realistic sense; which is to say, it does not allow inquiry into most of the critical problems that comprise the content of the world outside the school.' For mental health professionals, the book implicitly raises disturbing questions. The book may be faulted for its loose construction in parts and for not supplying a bibliography. Overall the book is enjoyable, highly readable, and above all subversive in that it advocates that people actually think. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - teaching
KW - subversive activity
KW - education
KW - curriculum
KW - mental health professionals
KW - 1970
KW - Curriculum
KW - Education
KW - Teaching
KW - Mental Health Personnel
KW - 1970
U2 - Postman, Neil; Weingartner, Charles. (1969); Teaching as a subversive activity; New York: Delacorte Press. 218 pp. $5.95
DO - 10.1037/h0097609
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Ng, K. Y.;
AU - Chase, T. N.;
AU - Colburn, R. W.;
AU - Kopin, I. J.;
T1 - L-dopa induced release of cerebral monoamines
CT - L-dopa induced release of cerebral monoamines
JO - Science
JF - Science
Y1 - 1970/10/02/
VL - 170
IS - Oct 2
SP - 76
EP - 77
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-3254; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 13; Journal Coden: SCIEAS; Section Heading: Pharmacology
N2 - L-Dopa (levodopa) markedly increased the efflux of tritiated dopamine and tritiated serotonin from rat brain slices. This action appeared contingent on the decarboxylation of L-dopa to dopamine, since it could be blocked by an inhibitor of L-amino acid decarboxylase. Selective destruction of catecholamine containing nerve terminals by 6-hydroxydopamine significantly decreased the uptake and release of tritiated dopamine but not that of tritiated serotonin.
KW - Levodopa--effects-;
KW - Antiparkinson agents--levodopa--effects, induced release of cerebral monoamines, from rat brain slices;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Epstein, E.;
AU - Ugel, A. R.;
T1 - Effects of topical mechlorethamine on skin lesions of psoriasis
CT - Effects of topical mechlorethamine on skin lesions of psoriasis
JO - Archives of Dermatology (USA)
JF - Archives of Dermatology (USA)
Y1 - 1970/11/01/
VL - 102
IS - Nov
SP - 504
EP - 506
SN - 0003987X
AD - Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 9-3195; Language: English; Trade Name: Mustargen; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine; References: 12; Journal Coden: ARDEAC; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Persis Mehta
N2 - The effectiveness of topical applications of aqueous solutions of mechlorethamine (Mustargen) hydrochloride on 12 patients with resistant psoriasis was determined in a double-blind study. Initial hypersensitivity tests using 0.1 to 50 mg./100 ml. of mechlorethamine HCl in all patients were negative, hence the patients were treated with weekly applications of 50 mg./100 ml. of the drug on one side of the body and placebo (lactose solution) on the other side. Ten patients showed definite improvement on the side treated with mechlorethamine and not on the other. Although no systemic toxicity was detected (as determined by several parameters), 9 patients in all became sensitized to the drug after 4 to 40 applications. Hence, a new double-blind study was designed in which the dosage was lowered to 0.5 mg./100 ml. of solution applied daily to previously untreated areas. No improvement was obtained either with the active drug or with lactose in the concentrations used. Local hypersensitivity was manifested by edema, erythema, pruritis and vesiculation and subsided within 7 to 10 days. Local hyperpigmentation was observed in some cases and usually persisted for no longer than one month after cessation of therapy.
KW - Mechlorethamine--hydrochloride-;
KW - Antineoplastic agents--mechlorethamine--hydrochloride, psoriasis, therapy, topical, lack of effect, in patients;
KW - Topical preparations--mechloethamine--hydrochloride, psoriasis, therapy, lack of effect, in patients;
KW - Psoriasis--mechlorethamine--hydrochloride, therapy, topical, lack of effect, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ADAMSON, RICHARD H.
T1 - The Cancer Problem: A Critical Analysis and Modern Synthesis.
JO - BioScience
JF - BioScience
Y1 - 1970/11//11/1/1970
VL - 20
IS - 21
M3 - Book Review
SP - 1178
EP - 1178
SN - 00063568
AB - The article reviews the book "The Cancer Problem: A Critical Analysis and Modern Synthesis," by A. C. Braun.
KW - Cancer
KW - Nonfiction
KW - Braun, A. C.
KW - Cancer Problem: A Critical Analysis & Modern Synthesis, The (Book)
N1 - Accession Number: 32099520; ADAMSON, RICHARD H. 1; Affiliations: 1 : National Institutes of Health, Bethesda, Md.; Source Info: 11/1/1970, Vol. 20 Issue 21, p1178; Subject Term: Cancer; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Steinberg, Alfred D.
AU - Talal, Norman
T1 - SUPPRESSION OF ANTIBODIES TO NUCLEIC ACIDS WITH POLYINOSINICPOLYCYTIDYLIC ACID AND CYCLOPHOSPHAMIDE IN MURINE LUPUS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1970/11//
VL - 7
IS - 5
M3 - Article
SP - 687
EP - 691
SN - 00099104
AB - NZB/NZW mice with active lupus were treated with polyinosinic-polycytidylic acid, a synthetic double stranded RNA, followed by cyclophosphamide to induce immunologic tolerance to nucleic acids, This combined regimen reduced serum antibodies to RNA and DNA to a greater degree than did cyclophosphamide alone. This report demonstrates that a specific Form of immunotherapy can he successfully employed to treat the serologic abnormalities of murine lupus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - NUCLEIC acids
KW - RNA
KW - LUPUS erythematosus
KW - DNA
KW - IMMUNOTHERAPY
N1 - Accession Number: 14587273; Steinberg, Alfred D. 1,2; Talal, Norman 1,2; Source Information: Nov70, Vol. 7 Issue 5, p687; Subject: IMMUNOGLOBULINS; Subject: NUCLEIC acids; Subject: RNA; Subject: LUPUS erythematosus; Subject: DNA; Subject: IMMUNOTHERAPY; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Jacobson, Arthur E
AU - Kaufmann, S Joel
AU - Raub, William F
T1 - Computer-assisted data management in medicinal chemistry-the use of a general-purpose text editor
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1970/11//
VL - 10
IS - 4
M3 - Article
SP - 248
EP - 255
SN - 00219576
AB - Wylbur, an interactive computer-based text-editor for the ibm 360/65, has been utilized as a chemical/biological information-handling system. Its applicability is illustrated with chemical and biological data on the 3-benzazocines (6, 7-benzomorphans), a class of strong analgetics in which a separation of analgetic activity and physical dependence liability has been achieved in animal species. By providing an open-ended, completely user-defined format, a simple means to match character strings and retrieve data records, and a convenient entree to the batch computation stream, wylbur appears to be a relatively inexpensive and useful data management tool to study chemical compounds and their biological effects.
N1 - Accession Number: ISTA0600774; Jacobson, Arthur E 1; Kaufmann, S Joel; Raub, William F; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland; Source Info: November 1970, Vol. 10 Issue 4, p248; Note: Update Code: 0600; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Serpick, A. A.;
AU - Carbone, P. P.;
T1 - Combination chemotherapy in the treatment of advanced Hodgkin's disease
CT - Combination chemotherapy in the treatment of advanced Hodgkin's disease
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/12/01/
VL - 73
IS - Dec
SP - 881
EP - 895
SN - 00034819
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, Building 10 Room 12N226, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-1008; Language: English; Chemical Name: Vincristine--57-22-7 Cyclophosphamide--6055-19-2 Procarbazine--671-16-9 Prednisone--53-03-2; References: 48; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Forty-three patients with advanced, primarily untreated Hodgkin's disease were treated with a combination of vincristine sulfate, nitrogen mustard (or cyclophosphamide), procarbazine hydrochloride, and prednisone, given in cyclical fashion for 6 months. The limiting toxicity was primarily bone marrow suppression and, although occasionally severe, was generally tolerable. Other toxicity such as alopecia and neurotoxicity were troublesome but reversible. The response rate was superior to that previously reported with the use of single drugs with 35 of 43, or 81% of the patients achieving a complete remission, defined as the complete disappearance of all tumor and return to normal performance status. The duration of these responses after all therapy was discontinued was gratifyingly long. It appears that combinations of effective drugs that act by different mechanisms and manifest different toxicities can be used effectively to increase the response rate and probably the survival of patients with sensitive tumors such as Hodgkin's disease.
KW - Vincristine--Hodgkin's disease-;
KW - Cyclophosphamide--Hodgkin's disease-;
KW - Procarbazine--Hodgkin's disease-;
KW - Prednisone--Hodgkin's disease-;
KW - Antineoplastic agents--Hodgkin's disease--combined therapy;
KW - Toxicity--vincristine--Hodgkin's disease, combined therapy;
KW - Toxicity--cyclophosphamide--Hodgkin's disease, combined therapy;
KW - Toxicity--procarbazine--Hodgkin's disease, combined therapy;
KW - Toxicity--prednisone--Hodgkin's disease, combined therapy;
KW - Combined therapy--Hodgkin's disease--use of vincristine, cyclophosphamide, procarbazine, and prednisone;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carbone, P. P.;
AU - Frost, J. K.;
AU - Feinstein, A. R.;
AU - Higgins, G. A.;
AU - Selawry, O. S.;
T1 - Lung cancer: perspectives and prospects
CT - Lung cancer: perspectives and prospects
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/12/01/
VL - 73
IS - Dec
SP - 1003
EP - 1024
SN - 00034819
AD - National Cancer Institute, Building 10, Room 2-B-46, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-0877; Language: English; References: 161; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2 - In this review, studies on the adjunctive treatment of lung cancer with antineoplastic agents are summarized.
KW - Antineoplastic agents--lung cancer--therapy, discussion of various drugs used;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lowenbraun, S.;
AU - DeVita, V. T.;
AU - Serpick, A. A.;
T1 - Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with Hodgkin's disease
CT - Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with Hodgkin's disease
JO - Blood
JF - Blood
Y1 - 1970/12/01/
VL - 36
IS - Dec
SP - 704
EP - 716
AD - Medical Service, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 8-1220; Language: English; Trade Name: Nitrogen Mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Procarbazine--671-16-9 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine (68:04); AHFS Class: Steroids, cortico- prednisone; References: 30; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - This article describes the use of a 4-drug regimen in the treatment of advanced Hodgkin's disease. Cyclic combination therapy with mechlorethamine, vincristine, procarbazine, and prednisone was used. Nineteen of the 27 patients had a complete response, and 4 more had partial responses. Fourteen of the 19 who responded completely are still in unmaintained remission 1-24 months from completion of therapy.
KW - Mechlorethamine--Hodgkin's disease-;
KW - Vincristine--Hodgkin's disease-;
KW - Procarbazine--Hodgkin's disease-;
KW - Prednisone--Hodgkin's disease-;
KW - Antineoplastic agents--Hodgkin's disease--combined therapy, cyclic, with mechlorethamine, vincristine, procarbazine and prednisone;
KW - Combined therapy--Hodgkin's disease--cyclic, with mechlorethamine, vincristine, procarbazine, and prednisone;
KW - Antineoplastic agents--mechlorethamine--combined therapy, cyclic, with vincristine, procarbazine, and prednisone, Hodgkin's disease;
KW - Antineoplastic agents--vincristine--combined therapy, cyclic, with mechlorethamine, procarbazine, and prednisone, Hodgkin's disease;
KW - Antineoplastic agents--procarbazine--combined therapy, cyclic, with mechlorethamine, vincristine, and prednisone, Hodgkin's disease;
KW - Steroids, cortico---prednisone--combined therapy, cyclic, with mechlorethamine, vincristine, and procarbazine, Hodgkin's disease;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frank, M. M.
AU - Gaither, Thelma
T1 - The Effect of Temperature on the Reactivity of Guinea-Pig Complement with γG and γM Haemolytic Antibodies.
JO - Immunology
JF - Immunology
Y1 - 1970/12//
VL - 19
IS - 6
M3 - Article
SP - 967
EP - 974
SN - 00192805
AB - Presents a study to define quantitatively the steps in the complement sequence where gammaG and gammaM antibodies differ in their interaction with complement component , with an ultimate goal of establishing more useful complement fixation tests. Determination of whether gammaM and gammaG antobodies differ in the mechanism by which they interact with complement components after the intitiation of complement fixation; Differences which exist between the activities gammaM and gammaG hemolysins at four degrees; Persistence of the difference e in the reactions in the sites SAC1, SAC14, SAC142 and SAC1423.
KW - IMMUNOGLOBULINS
KW - HEMOLYSIS & hemolysins
KW - BLOOD
KW - IMMUNITY
KW - ANTIGEN-antibody reactions
KW - SERUM
KW - GLOBULINS
N1 - Accession Number: 14528311; Frank, M. M. 1; Gaither, Thelma 1; Source Information: Dec70, Vol. 19 Issue 6, p967; Subject: IMMUNOGLOBULINS; Subject: HEMOLYSIS & hemolysins; Subject: BLOOD; Subject: IMMUNITY; Subject: ANTIGEN-antibody reactions; Subject: SERUM; Subject: GLOBULINS; Number of Pages: 8p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Frank, M. M.
AU - Gaither, Thelma
T1 - Evidence that Rabbit γG Haemolysin is Capable of Utilizing Guinea-Pig Complement More Efficiently than Rabbit γM Haemolysin.
JO - Immunology
JF - Immunology
Y1 - 1970/12//
VL - 19
IS - 6
M3 - Article
SP - 975
EP - 981
SN - 00192805
AB - Sheep erythrocytes sensitized with rabbit γG anti-Forssman haemolysin may be haemolysed more efficiently and to a greater extent by limited amounts of guinea-pig complement components than are cells sensitized with γM anti-Forssman haemolysin. This apparent difference, noted in all components titrations, was two-fold or greater in titrations of C2 and components following C2 in the haemolytic sequence. Neither site to site transfer of C2 nor AC 142 could account for the 100 per cent greater haemolytic efficiency of C2 in haemolytic assays. These results indicate that immunoglobulin class plays a more complex role in immune haemolysis than simple initiation of complement fixation and suggest that γG complement fixing sites may be more efficient than γM sites in producing biological damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROCYTES
KW - BLOOD cells
KW - HEMOLYSIS & hemolysins
KW - IMMUNITY
KW - BLOOD
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 14528338; Frank, M. M. 1; Gaither, Thelma 1; Source Information: Dec70, Vol. 19 Issue 6, p975; Subject: ERYTHROCYTES; Subject: BLOOD cells; Subject: HEMOLYSIS & hemolysins; Subject: IMMUNITY; Subject: BLOOD; Subject: ANTIGEN-antibody reactions; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Dresback, D. S.;
AU - Gallelli, J. F.;
T1 - Quantitative analysis and stability of 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide in acidic aqueous solutions
CT - Quantitative analysis and stability of 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide in acidic aqueous solutions
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/12/01/
VL - 59
IS - Dec
SP - 1829
EP - 1833
SN - 00223549
AD - Pharmaceutical Development Service, Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2303; Language: English; Trade Name: NSC-82196; Generic Name: Carboxamide; References: 6; Journal Coden: JPMSAE; Section Heading: Drug Stability; Preliminary Drug Testing
N2 - Methods of quantitative analysis by UV spectrophotometric, colorimetric, and ionic chloride determination are reported for 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196), a promising antileukemic agent, in the presence of its degradation products. With the exception of the ionic chloride method of analysis of samples exposed to light, all 3 methods showed good agreement for stability studies of NSC-82196 in acidic aqueous solutions exposed to light and dark and stored at 25\DG/. A sterile lyophilized hydrochloride salt of NSC-82196 for parenteral use, reconstituted with water for injection, was found to have a t\IF/1/2 \BS/= 150 minutes at 25\DG/ and t\IF/1/2 \BS/= 65 hours at 4\DG/. Graphs and tables are included.
KW - Carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)--;
KW - Stability--carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-, in acidic aqueous solutions;
KW - Analysis--carboxamide--5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-, quantitative, and stability, in acidic aqueous solutions;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Parry, Hugh J.
AU - Balter, Mitchell B.
AU - Cisin, Ira H.
T1 - PRIMARY LEVELS OF UNDERREPORTING PSYCHOTROPIC DRUG USE.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1970///Winter70-Winter71
VL - 34
IS - 4
M3 - Article
SP - 582
EP - 592
PB - Oxford University Press / USA
SN - 0033362X
AB - The present article reports on a methodological problem: The extent to which use of psychotropes is underreported by various population subgroups and under various techniques of questioning. Comparative findings for antibiotic use are also reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Psychiatric drugs
KW - Drug abuse
KW - Antibiotics
KW - Psychopharmacology
KW - Behavioral toxicology
N1 - Accession Number: 5414842; Parry, Hugh J. 1; Balter, Mitchell B. 2; Cisin, Ira H. 3,4; Affiliations: 1: Associate Director, Social Research Group, George Washington University, Washington D.C.; 2: Chief of the Special Studies Section, Psychopharmacology Research Branch of the National Institute of Mental Health; 3: Director of the Social Research Group, George Washington University; 4: Professor of Sociology, George Washington University; Issue Info: Winter70-Winter71, Vol. 34 Issue 4, p582; Subject Term: Psychiatric drugs; Subject Term: Drug abuse; Subject Term: Antibiotics; Subject Term: Psychopharmacology; Subject Term: Behavioral toxicology; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jacqueline J.
AU - Burke, Allyn D.
T1 - The effectiveness of the Charters', scrub and roll methods of toothbrushing by professionals in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1970/12//
VL - 78
IS - 7
M3 - Article
SP - 459
EP - 463
SN - 0029845X
AB - The effectiveness of the Charters', scrub, and roll methods of toothbrushing by professional dental personnel in removing plaque was studied in 60 United States Army recruits. An interaction between method of brushing and brusher was found, indicating that no one method was clearly most effective in removing plaque. One brusher removed significantly more plaque with the Charters' method than with the roll method, whereas the other brusher obtained a significantly greater reduction in plaque with the scrub method than with either the Charters' or the roll methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL plaque
KW - DENTAL deposits
KW - DENTAL personnel -- United States
KW - MEDICAL personnel
KW - UNITED States
N1 - Accession Number: 16615062; Frandsen, Asger M. 1; Barbano, Joseph P. 2; Suomi, John D. 2; Chang, Jacqueline J. 2; Burke, Allyn D. 3; Source Information: 1970, Vol. 78 Issue 7, p459; Subject: DENTAL plaque; Subject: DENTAL deposits; Subject: DENTAL personnel -- United States; Subject: MEDICAL personnel; Geographic Terms: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - HOOD, LEROY E.
AU - POTTER, MICHAEL
AU - MCKEAN, DAVID J.
T1 - Immunoglobulin Structure: Amino Terminal Sequences of Kappa Chains from Genetically Similar Mice (BALB/c).
JO - Science
JF - Science
Y1 - 1970/12/11/
VL - 170
IS - 3963
M3 - Article
SP - 1207
EP - 1210
SN - 00368075
AB - The amino terminal portion of 20 kappa chains from the highly inbred BALB/c mouse has been examined on an automatic protein sequencer. These proteins can be divided into at least nine groups (subgroups) based on sequence patterns which are so distinct that each subgroup is probably encoded by at least one germ-line gene. The subgroups of mouse kappa chains are generally quite different from those of human kappa chains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438544; HOOD, LEROY E. 1; POTTER, MICHAEL 1; MCKEAN, DAVID J. 2; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Biology Department, Johns Hopkins University, Baltimore, Maryland; Issue Info: 12/11/1970, Vol. 170 Issue 3963, p1207; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZBAR, BERTON
AU - BERNSTEIN, IRWIN
AU - TANAKA, TOMIKO
AU - RAPP, HERBERT J.
T1 - Tumor Immunity Produced by the Intradermal Inoculation of Living Tumor Cells and Living Mycobacterium bovis (Strain BCG).
JO - Science
JF - Science
Y1 - 1970/12/11/
VL - 170
IS - 3963
M3 - Article
SP - 1217
EP - 1218
SN - 00368075
AB - The intradermal inoculation of mixtures containing living tumor cells and living Mycobacterium bovis (strain BCG) into unimmunized syngeneic guinea pigs results in an inflammatory reaction to the BCG, and there is no progressive tumor growth. In the absence of BCG the tumor grows progressively, metastasizes, and kills the animal. By conventional methods, it has not been possible to immunize syngeneic guinea pigs to the tumor used. Guinea pigs that receive mixtures of BCG and tumor cells, however, develop specific systemic tumor immunity as measured by delayed cutaneous hypersensitivity and by suppression of tumor growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438549; ZBAR, BERTON 1; BERNSTEIN, IRWIN 1; TANAKA, TOMIKO 1; RAPP, HERBERT J. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/11/1970, Vol. 170 Issue 3963, p1217; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WOOD, WILLIAM C.
AU - MORTON, DONALD L.
T1 - Microcytotoxicity Test: Detection in Sarcoma Patients of Antibody Cytotoxic to Human Sarcoma Cells.
JO - Science
JF - Science
Y1 - 1970/12/18/
VL - 170
IS - 3964
M3 - Article
SP - 1318
EP - 1320
SN - 00368075
AB - A microcytotoxicity test has been used to detect a factor cytotoxic for human sarcoma cells; the factor was found in serums from 70 percent of sarcoma patients, 58 percent of their family members, and 8 percent of serums from normal blood donors. This cytotoxin is an antibody against a common cell surface sarcoma antigen since it is specific for sarcoma cells, is complement dependent, and is extractable with the globulin fraction of serum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87924152; WOOD, WILLIAM C. 1; MORTON, DONALD L. 1; Affiliations: 1: Tumor Immunology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1318; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEMBERGER, LOUIS
AU - SILBERSTEIN, STEPHEN D.
AU - AXELROD, JULIUS
AU - KOPIN, IRWIN J.
T1 - Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man.
JO - Science
JF - Science
Y1 - 1970/12/18/
VL - 170
IS - 3964
M3 - Article
SP - 1320
EP - 1322
SN - 00368075
AB - Δ9-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t1/2 = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Δ9-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87924153; LEMBERGER, LOUIS 1; SILBERSTEIN, STEPHEN D. 1; AXELROD, JULIUS 1; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1320; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - COHN, CAL K.
AU - DUNNER, DAVID L.
AU - AXELROD, JULIUS
T1 - Reduced Catechol-O-Methyltransferase Activity in Red Blood Cells of Women with Primary Affective Disorder.
JO - Science
JF - Science
Y1 - 1970/12/18/
VL - 170
IS - 3964
M3 - Article
SP - 1323
EP - 1324
SN - 00368075
AB - Red blood cell catechol-O-methyltransferase, histamine-N-methyltransferase, and a methanol-forming enzyme were examined in a number of subjects with mental diseases. Catechol-O-methyltransferase activity was significantly reduced in female subjects with primary affective disorder (depression) as compared to normal women and men, men with primary affective disorder, and schizophrenic men and women. In depressed women, histamine-N-methyltransferase activity was elevated and the methanol-forming enzyme was unchanged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87924154; COHN, CAL K. 1; DUNNER, DAVID L. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1323; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MANO, NORI-ICHI
T1 - Changes of Simple and Complex Spike Activity of Cerebellar Purkinje Cells with Sleep and Waking.
JO - Science
JF - Science
Y1 - 1970/12/18/
VL - 170
IS - 3964
M3 - Article
SP - 1325
EP - 1327
SN - 00368075
AB - Action potentials of cerebellar Purkinje cells were observed in intact monkeys during sleep and waking. Purkinje cells exhibit two sorts of action potentials, called simple and complex spikes, and these two sorts of spikes were differently affected by sleep. Simple-spike activity (generated by the parallel fiber inputs to the Purkinje cell) was highest during sleep with rapid eye movements as compared with both waking and sleep with electroencephalographic slow waves. In contrast, complex-spike activity (generated by the climbing fiber inputs to the Purkinje cell) was lowest during sleep with rapid eye movements. The complex action potential of the Purkinje cell consists of an initial large spike followed by one or more smaller secondary spikes, and the number of these secondary spikes was found to be independent of the background discharge frequency of the simple spike. This independence suggests a possible role of presynaptic factors rather than the excitability level of the Purkinje cell itself in determining the number of secondary discharges occurring in the complex spike. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87924155; MANO, NORI-ICHI 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1970, Vol. 170 Issue 3964, p1325; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Urokinase Pulmonary Embolism Trial Study Group;
T1 - Urokinase Pulmonary Embolism Trial. Phase 1 results. A cooperative study
CT - Urokinase Pulmonary Embolism Trial. Phase 1 results. A cooperative study
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1970/12/21/
VL - 214
IS - Dec 21
SP - 2163
EP - 2172
AD - Dr. J. M. Stengle, National Heart and Lung Institute, National Institutes of Health, 4A-03 Bldg. 31, Bethesda, Maryland 20014
N1 - Accession Number: 8-2463; Language: English; Chemical Name: Urokinase--9039-53-6 Heparin--9005-49-6; Therapeutic Class: (20:12.04); AHFS Class: Anticoagulants heparin (44:00); AHFS Class: Enzymes urokinase; References: 20; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - In a randomized, national cooperative trial, urokinase and subsequent heparin sodium therapy, when compared to heparin therapy alone, significantly accelerated the resolution rate of pulmonary thromboemboli at 24 hours as shown by pulmonary arteriograms, lung scans, and right-sided pressure measurements. No significant differences in recurrence rate of pulmonary embolism or in the 2-week mortality were observed. Bleeding, which occurred in 45% of patients receiving urokinase as contrasted to 27% in the heparin group, was the only complication of urokinase therapy. This increase in bleeding seen with urokinase was closely associated with the invasive procedures necessary to obtain the arteriographic and hemodynamic information. Because the urokinase regimen did not usually achieve complete or nearly complete thrombolysis, and because of its hemorrhagic property, further studies with urokinase in pulmonary thromboembolism are indicated before specific therapeutic recommendations can be made.
KW - Urokinase--and subsequent heparin-;
KW - Heparin--alone and subsequent to urokinase-;
KW - Anticoagulants--heparin--alone and subsequent to urokinase, in Urokinase Pulmonary Embolism Trial;
KW - Enzymes--urokinase--and subsequent heparin, in Urokinase Pulmonary Embolism Trial, comparison with heparin alone;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bunney, W. E.;
AU - Brodie, H. K. H.;
AU - Murphy, D. L.;
AU - Goodwin, F. K.;
T1 - Studies of alpha-methyl-para-tyrosine, L-dopa and L-tryptophan in depression and mania
CT - Studies of alpha-methyl-para-tyrosine, L-dopa and L-tryptophan in depression and mania
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1971/01/01/
VL - 127
IS - Jan
SP - 872
EP - 881
SN - 0002953X
AD - National Institute of Mental Health, Laboratory of Clinical Science, Section of Psychiatry, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 9-0764; Language: English; Chemical Name: Levodopa--59-92-7 Tryptophan--73-22-3 \a/-Methyl-p-tyrosine--658-48-0; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants levodopa (28:16.04); AHFS Class: Antidepressants tryptophan (28:16.04); AHFS Class: Antidepressants \a/-methyl-p-tyrosine; References: 52; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - L-Dopa (levodopa), L-tryptophan and alpha-methyl-para-tyrosine (I) were administered to depressed and manic patients in an attempt to decrease their psychopathology and to test the monoamine theory of affective disorders. The drugs were administed in a double-blind nonrandom procedure. The average duration of administration and average maximum dose of the compounds were: alpha-methyl-para-tyrosine 3 g. for 15 days, levodopa 7 g. for 30 days and tryptophan 8 g. for 16 days. L-dopa and I clearly altered mood and thought patterns in some patients, while L-tryptophan was less active. Analysis of urinary and cerebrospinal fluid amine metabolites documented the metabolic effects of the compounds during periods of behavioral changes.
KW - Levodopa--effects-;
KW - Tryptophan--effects-;
KW - \a/-Methyl-p-tyrosine--effects-;
KW - Antidepressants--levodopa--effects, in depression and mania, in patients;
KW - Antidepressants--tryptophan--effects, in depression and mania, in patients;
KW - Antidepressants--\a/-methyl-p-tyrosine--effects, in depression and mania, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Markley, K.;
T1 - Vaccine prophylaxis for pseudomonas infections
CT - Vaccine prophylaxis for pseudomonas infections
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/01/01/
VL - 74
IS - Jan
SP - 140
SN - 00034819
AD - Laboratory of Biochemical Pharmacology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-1543; Language: English; References: 15; Publication Type: Editorial Notes; Journal Coden: AIMEAS; Section Heading: Microbiology; Investigational Drugs; Abstract Author: Judith A. Kepler
N2 - The development of an effective pseudomonas vaccine for the prophylaxis of fatal pseudomonas infection in burned patients has been reported. The advent of vaccine and immune globulin for pseudomonas infections adds another dimension to current therapy, which includes topical and systemic antibiotics against pseudomonas, gamma globulin, and control of the bacterial environment of the patient. Although effective control of infection by pseudomonas is now possible, however, the intrinsic susceptibility of the patients often leads to infection by other organisms.
KW - Vaccines--pseudomonas--prophylaxis in burned patients;
KW - Infections--pseudomonas--prophylaxis, vaccine, in burned patients;
KW - Drugs--clinical effectiveness--pseudomonas vaccine, prophylaxis in burned patients;
KW - Pseudomonas aeruginosa--vaccines--prophylaxis, in burned patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Hodes, Louis
T1 - Solving problems by formula manipulation in logic and linear inequalities
JO - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 553-559. 1 Tab. 9 Ref. See Isa 72-005/y
JF - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 553-559. 1 Tab. 9 Ref. See Isa 72-005/y
Y1 - 1971///
M3 - Book
N1 - Accession Number: ISTA0700327; Hodes, Louis 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1971; Note: Update Code: 0700; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Lee, Richard C T
T1 - Fuzzy logic and the resolution principle
JO - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 560-567. 1 Illus. 27 Ref. See Isa 72-005/y
JF - In Second International Joint Conference On Artificial Intelligence, Imperial College, London, 1st-3rd September 1971. 1971. The British Computer Society, 29 Portland Place, London, Win 4ap, Uk. P. 560-567. 1 Illus. 27 Ref. See Isa 72-005/y
Y1 - 1971///
M3 - Book
AB - Problem-solving systems using two-valued logic suffer from one drawback; they cannot handle fuzzy, or uncertain, information. In this paper, the author recommends the use of fuzzy logic, which is based on the concept of fuzzy sets and first order predicate calculus. It is proved that, in fuzzy logic, a set of clauses is unsatisfiable if it is unsatisfiable in two-valued logic. It is also shown that if the most unreliable clause of a set of clauses has a truth-value a>0.5, then all the logical consequences obtained by repeatedly applying the resolution principle has truth-value never smaller than a. Implications of these results for applying fuzzy logic to problem-solving are discussed
N1 - Accession Number: ISTA0700329; Lee, Richard C T 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1971; Note: Update Code: 0700; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Hartwell, J. L.;
T1 - Plants used against cancer. A survey (continued)
CT - Plants used against cancer. A survey (continued)
JO - Lloydia
JF - Lloydia
Y1 - 1971/01/01/
VL - 34
IS - Jan
SP - 103
EP - 160
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 9-0269; Language: English; Journal Coden: LLOYA2; Section Heading: Pharmacognosy; Pharmacology; Abstract Author: M. A. Iyengar
N2 - In a continuing article, a record of several plants from 12 families along with their references embracing the history of medicine, pharmacology, materia medica, medical botany, ethnobotany and folklore has been presented here. Both technical literature and folklore could be sources of information on use of plants for the treatment of cancer and other growths, and thus these records might be useful in providing leads for the laboratory investigation of other plants and the development of useful drugs in the therapy of human cancer. This comprehensive survey consists of both published literature and unpublished data. The 12 different families appearing in this article are: Primulaceae, Proteaceae, Punicaceae, Pyrolaceae, Rafflesiaceae, Ranunculaceae, Resedaceae, Rhamnaceae, Rhizophoraceae, Rosaceae, Rubiaceae and Rutaceae.
KW - Rhizophoraceae--antineoplastic agents--survey;
KW - Rosaceae--antineoplastic agents--survey;
KW - Rubiaceae--antineoplastic agents--survey;
KW - Rutaceae--antineoplastic agents;
KW - History--plants agents--survey survey of 12 different families with reference to antineoplastic effects;
KW - Antineoplastic agents--plants--survey, 12 families;
KW - Plants--antineoplastic agents--survey, of 12 families;
KW - Primulaceae--antineoplastic agents--survey;
KW - Proteaceae--antineoplastic agents--survey;
KW - Punicaceae--antineoplastic agents--survey;
KW - Pyrolaceae--antineoplastic agents--survey;
KW - Rafflesiaceae--antineoplastic agents--survey;
KW - Ranunculaceae--antineoplastic agents--survey;
KW - Resedaceae--antineoplastic agents--survey;
KW - Rhamnaceae--antineoplastic agents--survey;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Schneider, John H
T1 - Selective dissemination and indexing of scientific information
JO - Science 173(3994), 300-308 (1971 July 23). 52 Ref
JF - Science 173(3994), 300-308 (1971 July 23). 52 Ref
Y1 - 1971///
M3 - Book Chapter
AB - Some basic aspects of sdi (selective dissemination of information) systems are presented, and recent developments and problems are described. Two different approaches to indexing information for sdi are discussed, emphasizing the desirability of using enumerative hierarchical classifications to improve the precision and quality of matching scientists with useful documents.
N1 - Accession Number: ISTA0700189; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland.; Source Info: 1971; Note: Update Code: 0700; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - MOHIT, BEHZAD
AU - KANG FAN
T1 - Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma.
JO - Science
JF - Science
Y1 - 1971/01/08/
VL - 171
IS - 3966
M3 - Article
SP - 75
EP - 77
SN - 00368075
AB - A hybrid cell line was established by cell fusion between a cloned Balbic myeloma that is resistant to 8-azaguanine and produces immunoglobulin (yG and free kappa chain) and C57BL/6N lymphoma that is resistant to bromodeoxyuridine and does not produce immunoglobulins. The hybrid cells contained the membrane antigens of both parents; they synthesized free kappa chain; no synthesis of γG (γ2a) heavy chain was detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104232; MOHIT, BEHZAD 1; KANG FAN 1; Affiliations: 1: Cell Chemistry Laboratory, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethescla, Maryland 20014; Issue Info: 1/ 8/1971, Vol. 171 Issue 3966, p75; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WURTZ, ROBERT H.
AU - GOLDBERG, MICHAEL E.
T1 - Superior Coiliculus Cell Responses Related to Eye Movements in Awake Monkeys.
JO - Science
JF - Science
Y1 - 1971/01/08/
VL - 171
IS - 3966
M3 - Article
SP - 82
EP - 84
SN - 00368075
AB - Single cell responses were recorded from the superior colliculus of awake monkeys trained to move their eyes. A class of cells that discharged before eye movements was found in the intermediate and deep layers of the colliculus. The response of the cells was most vigorous before saccadic eye movements within a particular range of directions. These cells had no visual receptive fields, and visually guided eye movements were not necessary for their discharge, since they responded in total darkness before spontaneous eye movements and vestibular nystagmus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104235; WURTZ, ROBERT H. 1; GOLDBERG, MICHAEL E. 1; Affiliations: 1: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/ 8/1971, Vol. 171 Issue 3966, p82; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WILSON, W. E.
AU - FISHBEIN, L.
AU - CLEMENTS, S. T.
T1 - DDT: Participation in Ultraviolet-Detectable, Charge-Transfer Complexation.
JO - Science
JF - Science
Y1 - 1971/01/15/
VL - 171
IS - 3967
M3 - Article
SP - 180
EP - 182
SN - 00368075
AB - The chlorophenyl groups of DDT and several of its metabolites are capable of participating in a charge-transfer interaction with tetracyanoethylene detectable in the ultraviolet region of the spectrum. In addition, during a change of state DDT undergoes ultraviolet spectral alterations that closely resemble those previously claimed to support the hypothesis suggesting charge-transfer interaction between this pesticide and a component of insect nerve tissue. The pesticide DDT possesses structural characteristics that would permit it to participate in several types of molecular association. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438495; WILSON, W. E. 1; FISHBEIN, L. 1; CLEMENTS, S. T. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p180; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SIGGINS, G. R.
AU - OLIVER, A. P.
AU - HOFFER, B. J.
AU - BLOOM, F. E.
T1 - Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells.
JO - Science
JF - Science
Y1 - 1971/01/15/
VL - 171
IS - 3967
M3 - Article
SP - 192
EP - 194
SN - 00368075
AB - Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438500; SIGGINS, G. R. 1; OLIVER, A. P. 1; HOFFER, B. J. 1; BLOOM, F. E. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p192; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - CRAYTON, JOHN W.
AU - NICOLL, ROGER A.
T1 - Supraoptic Neurosecretory Cells: Autonomic Modulation.
JO - Science
JF - Science
Y1 - 1971/01/15/
VL - 171
IS - 3967
M3 - Article
SP - 206
EP - 207
SN - 00368075
AB - Neurosecretory cells in the supraoptic nuclei of anesthetized cats were antidromically identified by electrical stimulation of the posterior pituitary. The responses of these units to afferent volleys from vagal and carotid sinus nerves were examined with a computer of average transients. Synaptic excitation of neurosecretory cells by stimulation of these pathways demonstrates the existence of excitatory inputs from vagal and carotid sinus nerve afferents. Since these pathways are involved in the release of antidiuretic hormone, the results support the hypothesis that its release is related to an increase in discharge frequency of supraoptic neurosecretory cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438507; BARKER, JEFFERY L. 1; CRAYTON, JOHN W. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p206; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - CRAYTON, JOHN W.
AU - NICOLL, ROGER A.
T1 - Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity.
JO - Science
JF - Science
Y1 - 1971/01/15/
VL - 171
IS - 3967
M3 - Article
SP - 207
EP - 210
SN - 00368075
AB - Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-β-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine release of antidiuretic hormone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438508; BARKER, JEFFERY L. 1; CRAYTON, JOHN W. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/15/1971, Vol. 171 Issue 3967, p207; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NAHMIAS, A. J.
AU - LONDON, W. T.
AU - CATALANO, L. W.
AU - FUCCILLO, D. A.
AU - SEVER, J. L.
AU - GRAHAM, C.
T1 - Genital Herpesvirus Hominis Type 2 Infection: An Experimental Model in Cebus Monkeys.
JO - Science
JF - Science
Y1 - 1971/01/22/
VL - 171
IS - 3968
M3 - Article
SP - 297
EP - 298
SN - 00368075
AB - Genital infection with herpesvirus hominis type 2 was established in ten female cebus monkeys. Clinical and laboratory findings in the cebus mimic closely those observed in humans, thus providing an experimental model which may be used in the study of the possible role of genital herpetic infection in cervical cancer and in perinatal and chronic neurological diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Capuchin monkeys
KW - Herpesvirus diseases in animals
KW - DISEASES
KW - Animal models in research
KW - Herpes simplex virus
KW - Genitalia
KW - Herpes genitalis
KW - Cervical cancer -- Risk factors
KW - Nervous system
KW - RISK factors
N1 - Accession Number: 85104275; NAHMIAS, A. J. 1; LONDON, W. T.; CATALANO, L. W.; FUCCILLO, D. A.; SEVER, J. L. 2; GRAHAM, C. 3; Affiliations: 1: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303; 2: Perinatal Research Branch, National Institutes of Health, Bethesda, Maryland; 3: Yerkes Primate Research Center, Emory University, Atlanta; Issue Info: 1/22/1971, Vol. 171 Issue 3968, p297; Thesaurus Term: Capuchin monkeys; Thesaurus Term: Herpesvirus diseases in animals; Thesaurus Term: DISEASES; Thesaurus Term: Animal models in research; Subject Term: Herpes simplex virus; Subject Term: Genitalia; Subject Term: Herpes genitalis; Subject Term: Cervical cancer -- Risk factors; Subject Term: Nervous system; Subject Term: RISK factors; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PAUL, MICHAEL I.
AU - CRAMER, HINRICH
AU - BUNNEY JR., WILLIAM E.
T1 - Urinary Adenosine 3',5'-Monophosphate in the Switch Process from Depression to Mania.
JO - Science
JF - Science
Y1 - 1971/01/22/
VL - 171
IS - 3968
M3 - Article
SP - 300
EP - 303
SN - 00368075
AB - Marked elevations of urinary adenosine 3',5'-monophosphate occurred on the day of rapid switch from a depressed into a manic state in patients' with manic-depressive illness. It is suggested that this increase might serve a trigger function for the process by which catecholamines are elevated during the manic phase of the illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bipolar disorder
KW - Urinalysis
KW - Cyclic adenylic acid
KW - Catecholamines
KW - Mania
KW - Mental depression
N1 - Accession Number: 85104277; PAUL, MICHAEL I. 1; CRAMER, HINRICH 2; BUNNEY JR., WILLIAM E. 3; Affiliations: 1: Neuropsychiatric Institute, Ceiter for the Health Sciences, University of California, Los Anugeles 90024; 2: Laboratory of Chelinical Pharmacology, National Heart and Lung Institute, Bethesa, Maryland 20014; 3: Laboratory of Clinical Scienice, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/22/1971, Vol. 171 Issue 3968, p300; Subject Term: Bipolar disorder; Subject Term: Urinalysis; Subject Term: Cyclic adenylic acid; Subject Term: Catecholamines; Subject Term: Mania; Subject Term: Mental depression; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Meyer, H. M.;
AU - Parkman, P. D.;
T1 - Rubella vaccination. A review of practical experience
CT - Rubella vaccination. A review of practical experience
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/01/25/
VL - 215
IS - Jan 25
SP - 613
EP - 619
AD - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-2314; Language: English; References: 36; Journal Coden: JAMAAP; Section Heading: Pharmacology; Abstract Author: Dale E. Johnson
N2 - Rubella virus vaccine became commercially available in the United States on June 10, 1969, and by October 1, 1970, approximately 28 million doses had been distributed for domestic use. The earlier experimental data pertaining to vaccine safety have been supported by the larger experience since licensure. Troublesome reactions clearly associated with immunization have largely been confined to rubella-like symptoms of joint pain and related complaints. There is no evidence that community-wide vaccine use has posed a significant risk of attenuated virus transmission to contacts. The greatest preventable problem attending immunization has been the inadvertent inoculation of pregnant women. New studies have furnished additional information concerning the quality and durability of vaccine-induced immunity. There has been some disagreement among scientists in the interpretation of these and other data bearing on the national immunization program. The authors are of the opinion that the present recommendations for vaccine use are sound and represent the best of the options currently available for preventing maternal-fetal rubella in the United States.
KW - Rubella vaccines--virus-;
KW - Immunization--rubella--review of practical experience with rubella virus vaccine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - FRENSDORFF, ASHER
AU - JONES, PATRICIA P.
AU - BERWALD-NETTER, YOHEVED
AU - CEBRA, JOHN J.
AU - MAGE, ROSE
T1 - Selective Stimulation of Allelic Expression: Effect of Antibodies to Allotypic Markers on Lymphoid Cells.
JO - Science
JF - Science
Y1 - 1971/01/29/
VL - 171
IS - 3969
M3 - Article
SP - 391
EP - 394
SN - 00368075
AB - Peripheral blood leukocytes from rabbits which were heterozygous (b5/b9) for markers on their immunoglobulin light chains were maintained in vitro for up to 24 hours in the presence or absence of antibody to b9. After culture they were transferred into lethally irradiated b4/b4 hosts. Recipients of cells exposed to antibodies to allotype markers showed a striking increase in concentration of circulating b9 molecules and number of b9 plasma cells in their spleens compared to control animals receiving untreated cells from the same donor. There was no appreciable difyerence between the two groups of recipients with respect to their content of b5 molecules and immunocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104317; FRENSDORFF, ASHER 1; JONES, PATRICIA P. 1; BERWALD-NETTER, YOHEVED 1; CEBRA, JOHN J. 1; MAGE, ROSE 2; Affiliations: 1: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p391; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DAWE, C. J.
AU - WHANG-PENG, J.
AU - MORGAN, W. D.
AU - HEARON, E. C.
AU - KNUTSEN, T.
T1 - Epithelial Origin of Polyoma Salivary Tumors in Mice: Evidence Based on Chromosome-Marked Cells.
JO - Science
JF - Science
Y1 - 1971/01/29/
VL - 171
IS - 3969
M3 - Article
SP - 394
EP - 397
SN - 00368075
AB - Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of class'ical problens concerning epithelial as opposed to mesenchymal origin of neoplasms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104318; DAWE, C. J. 1; WHANG-PENG, J. 1; MORGAN, W. D. 1; HEARON, E. C. 1; KNUTSEN, T. 1; Affiliations: 1: Laboratory of Patholooy and Human Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p394; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ELLINWOOD, EVERETT H.
AU - COHEN, SIDNEY
T1 - Amphetamine Abuse.
JO - Science
JF - Science
Y1 - 1971/01/29/
VL - 171
IS - 3969
M3 - Article
SP - 420
EP - 421
SN - 00368075
N1 - Accession Number: 85104330; ELLINWOOD, EVERETT H. 1; COHEN, SIDNEY 2; Affiliations: 1: Duke University School of Medicine, Durham, North Carolina; 2: National Institute of Mental Health, Bethesda, Maryland; Issue Info: 1/29/1971, Vol. 171 Issue 3969, p420; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Crane, G. E.;
AU - Johnson, A. W.;
AU - Buffaloe, W. J.;
T1 - Long-term treatment with neuroleptic drugs and eye opacities
CT - Long-term treatment with neuroleptic drugs and eye opacities
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1971/02/01/
VL - 127
IS - Feb
SP - 1045
EP - 1049
SN - 0002953X
AD - Spring Grove State Hospital, Catonsville, Maryland 21228
AD - Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Maryland
N1 - Accession Number: 8-1826; Language: English; Chemical Name: Chlorpromazine--50-53-3; References: 14; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2 - Approximately 100 chronic schizophrenic patients were examined for drug-induced eye changes. The lens was affected in 36 patients, and the cornea in 19. There was a linear relationship between eye opacities and the total intake of drugs. Corneal opacities were also related to the intake of high doses of chlorpromazine over a short period of time. In most instances the ocular changes were irreversible. Despite heavy deposits in the anterior part of the eye, vision was unimpaired and the retina appeared to be intact.
KW - Chlorpromazine--toxicity-;
KW - Psychotherapeutic agents--toxicity--chronic schizophrenics examined for drug-induced eye changes;
KW - Toxicity--psychotherapeutic agents--chronic schizophrenics examined for drug-induced eye changes;
KW - Toxicity--chlorpromazine--corneal opacities, related to high doses;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lipsett, M. B.;
AU - Combs, J. W., Jr.;
AU - Catt, K.;
AU - Seigel, D. G.;
T1 - Problems in contraception
CT - Problems in contraception
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/02/01/
VL - 74
IS - Feb
SP - 251
EP - 263
SN - 00034819
AD - National Institute of Child Health and Human Development, Bldg. 10, Room 12-N-204, National Institutes of Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland
N1 - Accession Number: 8-1823; Language: English; References: 45; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2 - Recent trends in birth rate are evaluated and adverse effects of oral contraceptives are reviewed. A review of the processes involved in sperm and ovum maturation and fertilization shows many areas where other approaches to contraception may be fruitful.
KW - Contraceptives--problems and new approaches--discussion;
KW - Contraceptives, oral--adverse reactions--review;
KW - Toxicity--contraceptives, oral--review;
KW - Sociology--birth rate--trends, recent, discussion;
KW - Drugs, adverse reactions--contraceptives, oral--review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wyatt, R. J.;
AU - Fram, D. H.;
AU - Kupfer, D. J.;
AU - Synder, F.;
T1 - Total prolonged drug-induced REM sleep suppression in anxious-depressed patients
CT - Total prolonged drug-induced REM sleep suppression in anxious-depressed patients
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1971/02/01/
VL - 24
IS - Feb
SP - 145
EP - 155
AD - Laboratory of Clinical Psychobiology, DCBR, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0829; Language: English; Trade Name: Nardil; Generic Name: Phenelzine; Chemical Name: Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine; References: 64; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Phenelzine (Nardil) was administered to 6 nonpsychotic, anxious-depressed patients while daily behavioral and EEG sleep records were made. Total suppression of rapid eye movement (REM) sleep for from 14 to 40 nights resulted when doses up to 75 mg./day was given. When REM sleep was absent, behavior markedly improved and no morning recall of dreams occurred. Upon discontinuation of the drug, the REM sleep increased above baseline for all patients and up to 250% above normal; dreaming was also reported. Evidence from this study and others indicates that suppression of REM sleep might help to alleviate depression.
KW - Phenelzine--effects-;
KW - Antidepressants--phenelzine--depresses REM sleep, in depressed patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kupfer, D. J.;
AU - Wyatt, R. J.;
AU - Synder, F.;
AU - Davis, J. M.;
T1 - Chlorpromazine and sleep in psychiatric patients
CT - Chlorpromazine and sleep in psychiatric patients
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1971/02/01/
VL - 24
IS - Feb
SP - 185
EP - 189
AD - Laboratory of Clinical Psychobiology, Division of Clinical and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 8-2479; Language: English; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 19; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Chlorpromazine was investigated in 9 patients, ranging in age from 20 to 49 years, for its effect on rapid eye movement (REM) or dreaming sleep and on actual sleep. Oral administration of 100 mg. of chlorpromazine given during the daytime or at bedtime did not suppress REM sleep; in fact, the total REM sleep was increased proportionally to the increase in actual sleep.
KW - Chlorpromazine--sleep-;
KW - Tranquilizers--chlorpromazine--sleep, effects, in psychiatric patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, C. H., III;
AU - Carbone, P. P.;
T1 - Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro
CT - Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/02/01/
VL - 31
IS - Feb
SP - 185
EP - 190
SN - 00085472
AD - Medical Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2776; Language: English; References: 18; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - The effects of several antineoplastic agents on normal mouse bone marrow were studied with the use of an enriched methylcellulose system. Twenty-four hours after incremental doses, cyclophosphamide, mechlorethamine, and carmustine resulted in exponential decreases in the fraction of surviving in vitro colony-forming units per femur, while vinblastine, methotrexate, and polyinosinic-polycytidylic acid gave dose-response curves which showed that, despite increasing doses, a maximal kill of colony-forming units was approached.
KW - Antineoplastic agents--effects--on normal mouse bone marrow grown in vitro;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lawson, C. L.
AU - Slagle, James R.
AU - Farrell, Carl D.
T1 - Experiments in Automatic Learning for a Multipurpose Heuristic Program.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 91
EP - 99
SN - 00010782
AB - An automatic learning capability has been developed and implemented for use with the MULTIPLE (MULTIpurpose Program that LEarns) heuristic tree-searching program, which is presently being applied to resolution theorem-proving in predicate calculus. MULTIPLE's proving program (PP) uses two evaluation functions to guide its search for a proof of whether or not a particular goal is achievable. Thirteen general features of predicate calculus clauses were created for use in the automatic learning of better evaluation functions for PP. A multiple regression program was used to produce optimal coefficients for linear polynomial functions in terms of the features. Also, automatic data-handling routines were written for passing data between the learning program and the proving program, and for analyzing and summarizing results. Data was generally collected for learning (regression analysis) from the experience of PP. A number of experiments were performed to test the effectiveness and generality of the learning program. Results showed that the learning produced dramatic improvements in the solutions to problems which were in the same domain as those used for collecting learning data. Learning was also shown to generalize successfully to domains other than those used for data collection. Another experiment demonstrated that the learning program could simultaneously improve performance on problems in a specific domain and on problems in a variety of domains. Some variations of the learning program were also tested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER programming
KW - MATHEMATICAL analysis
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - MULTIVARIATE analysis
KW - CALCULUS -- Software
KW - adaptive
KW - artificial intelligence
KW - automatic learning
KW - heuristic
KW - learning
KW - LISP
KW - multiple regression
KW - problem-solving
KW - resolution
KW - self-modifying
KW - theorem-providing
KW - tree-searching
N1 - Accession Number: 5221545; Lawson, C. L.; Slagle, James R. 1; Farrell, Carl D. 2; Affiliations: 1: Stanford Artificial Intelligence Project, Stanford University, Stanford, California.; 2: Division of Computer Research and Technology, National Institutes of Health, Public Health Service.; Issue Info: Feb1971, Vol. 14 Issue 2, p91; Thesaurus Term: COMPUTER programming; Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: MULTIVARIATE analysis; Subject Term: CALCULUS -- Software; Author-Supplied Keyword: adaptive; Author-Supplied Keyword: artificial intelligence; Author-Supplied Keyword: automatic learning; Author-Supplied Keyword: heuristic; Author-Supplied Keyword: learning; Author-Supplied Keyword: LISP; Author-Supplied Keyword: multiple regression; Author-Supplied Keyword: problem-solving; Author-Supplied Keyword: resolution; Author-Supplied Keyword: self-modifying; Author-Supplied Keyword: theorem-providing; Author-Supplied Keyword: tree-searching; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 9p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Slagle, James R.
AU - Lee, Richard C.T.
T1 - Application of Game Tree Searching Techniques to Sequential Pattern Recognition
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 103
PB - Association for Computing Machinery
SN - 00010782
AB - A sequential pattern recognition (s.p.r.) procedure does not test all the features of a pattern at once. Instead, it selects a feature to be tested. After receiving the result of that test, the procedure either classifies the unknown pattern or selects another feature to be tested, etc. Medical diagnosis is an example of s.p.r. In this paper the authors suggest that s.p.r. Be viewed as a one-person game played against nature (chance). Virtually all the powerful techniques developed for searching two-person, strictly competitive game trees can easily be incorporated either directly or by analogy into s.p.r. Procedures. In particular, one can incorporate the 'miniaverage backing-up procedure' and the 'gramma procedure,' which are the analogs of the 'minimax backing-up procedure' and the 'alpha-beta procedure,' respectively. Some computer-simulated experiments in character recognition are presented. The results indicate that the approach is promising.
KW - COMPUTERS
KW - ELECTRONIC data processing
KW - SEQUENTIAL processing (Computer science)
N1 - Accession Number: 5221547; Slagle, James R.; Lee, Richard C.T. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: Feb71, Vol. 14 Issue 2, p103; Note: Publisher: Association for Computing Machinery; Note: Update Code: 0600; Subject Term: COMPUTERS; Subject Term: ELECTRONIC data processing; Subject Term: SEQUENTIAL processing (Computer science); Number of Pages: 8p; Illustrations: 13 diagrams; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - EVARTS, EDWARD V.
T1 - Neuroscience.
JO - Science
JF - Science
Y1 - 1971/02/19/
VL - 171
IS - 3972
M3 - Article
SP - 667
EP - 667
SN - 00368075
N1 - Accession Number: 85058492; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/19/1971, Vol. 171 Issue 3972, p667; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GESSA, G. L.
AU - TAGLIAMONTE, A.
AU - TAGLIAMONTE, P.
T1 - Aphrodisiac Effect of p-Chlorophenylalanine.
JO - Science
JF - Science
Y1 - 1971/02/19/
VL - 171
IS - 3972
M3 - Article
SP - 706
EP - 706
SN - 00368075
N1 - Accession Number: 85058511; GESSA, G. L. 1; TAGLIAMONTE, A. 1; TAGLIAMONTE, P. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/19/1971, Vol. 171 Issue 3972, p706; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Adamson, R. H.;
T1 - Antitumor activity of two antiviral drugs\M/rifampicin and tilorone
CT - Antitumor activity of two antiviral drugs\M/rifampicin and tilorone
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1971/02/20/
VL - 1
IS - Feb 20
SP - 398
SN - 00237507
AD - Section of Pharmacology and Experimental Therapeutics, Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0235; Language: English; Trade Name: Rifampicin; Generic Name: Rifampin; Chemical Name: Rifampin--13292-46-1 Tilorone--27591-97-5; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents rifampin (10:00); AHFS Class: Antineoplastic agents tilorone; Publication Type: Letters; Journal Coden: LANCAO; Section Heading: Preliminary Drug Testing; Abstract Author: Douglas L. Thompson
N2 - The antitumor activity of rifampicin (rifampin) and tilorone hydrochloride in ascitic Walker 256 carcinosarcoma was investigated. Both drugs were active against the tumor. Rifampin was equivalent in antitumor activity to poly I.poly C, but tilorone was more effective than either rifampin or poly I.poly C.
KW - Rifampin--antineoplastic agents-;
KW - Tilorone--hydrochloride-;
KW - Antineoplastic agents--rifampin--effects, against Walker 256 carcinosarcoma, in animals;
KW - Antineoplastic agents--tilorone--hydrochloride, effects, against Walker 256 carcinosarcoma, in animals;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - NICOLL, R. A.
T1 - Recurrent Excitation of Secondary Olfactory Neurons: A Possible Mechanism for Signal Amplification.
JO - Science
JF - Science
Y1 - 1971/02/26/
VL - 171
IS - 3973
M3 - Article
SP - 824
EP - 826
SN - 00368075
AB - Secondary neurons of the olfactory bulb can be excited monosynaptically after activation of neighboring secondary neurons by antidromic and orthodromic volleys. Recurrent collaterals of secondary neurons are proposed to synapse with other secondary neurons, thus forming a direct recurrent excitatory pathway. Such a positive feedback system could strengthen the original input signal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138366; NICOLL, R. A. 1; Affiliations: 1: National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/26/1971, Vol. 171 Issue 3973, p824; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Williams, R. B.;
AU - Sherter, C.;
T1 - Cardiac complications of tricyclic antidepressant therapy
CT - Cardiac complications of tricyclic antidepressant therapy
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/03/01/
VL - 74
IS - Mar
SP - 395
EP - 398
SN - 00034819
AD - reprints: Section of Psychobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014
AD - Department of Internal Medicine, Yale-New Haven Hospital, and the Veterans Administration Hospital, West Haven, Connecticut
N1 - Accession Number: 8-1892; Language: English; Chemical Name: Amitriptyline--50-48-6 Imipramine--50-49-7; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants amitriptyline (28:16.04); AHFS Class: Antidepressants imipramine; References: 26; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions
N2 - Two similar fatal cases of unresponsive cardiac standstill secondary to toxicity of tricyclic antidepressants are reported. One is a case of deliberate overdose (1.6 g.) of amitriptyline and the other represents toxicity of therapeutic doses of imipramine (25 mg. 3 times daily) in a patient pretreated with a catecholamine depleting agent (guanethidine). Tricyclic amine antidepressants block the uptake of catecholamines by the heart, allowing enzymatic degradation and further catecholamine depletion. This group of antidepressants should therefore be contraindicated in patients receiving drugs that deplete cardiac catecholamines.
KW - Amitriptyline--toxicity-;
KW - Imipramine--toxicity-;
KW - Antidepressants--amitriptyline--toxicity, fatal, overdose results in cardiac complications;
KW - Antidepressants--imipramine--toxicity, fatal, cardiac complications;
KW - Toxicity--amitriptyline--fatal, overdose, causes cardiac complications;
KW - Toxicity--imipramine--cardiac complications, fatal;
KW - Antidepressants--tricyclic--amines, contraindications, in patients receiving drugs that deplete cardiac catecholamines;
KW - Contraindications--antidepressants--tricyclic, amines, in patients receiving drugs that deplete cardiac catecholamines, fatal cases;
KW - Drug interactions--antidepressants--tricyclic amines, and drugs depleting cardiac catecholamines, fatal cases;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carter, S. K.;
AU - Broder, L.;
AU - Friedman, M.;
T1 - Streptozotocin and metastatic insulinoma
CT - Streptozotocin and metastatic insulinoma
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/03/01/
VL - 74
IS - Mar
SP - 445
EP - 446
SN - 00034819
AD - Cancer Therapy Evaluation Branch, National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 8-1670; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 12; Publication Type: Editorial; Journal Coden: AIMEAS; Section Heading: Preliminary Drug Testing; Pharmacology; Abstract Author: Judith A. Kepler
N2 - The history and development of the antineoplastic antibiotic, streptozotocin is outlined. The unique diabetogenic potential observed in large animal toxicology studies pointed the way toward trials in the treatment of metastatic insulinoma. Clinical data on the drug accumulated to date is reviewed.
KW - Streptozotocin--history-;
KW - Toxicity studies--streptozotocin--diabetogenic potential indicates usefulness in metastatic insulinoma;
KW - Antineoplastic agents--streptozotocin--insulinoma, metastatic, therapy;
KW - History--streptozotocin--and development, and use in metastatic insulinoma;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hansen, H. H.;
AU - Selawry, O. S.;
AU - Muggia, F. M.;
AU - Walker, M. D.;
T1 - Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037)
CT - Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037)
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/03/01/
VL - 31
IS - Mar
SP - 223
EP - 227
SN - 00085472
AD - National Cancer Institute\M/Veterans Administration Medical Oncology Service, Medical Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-1629; Language: English; Trade Name: NSC-79037; Generic Name: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; References: 19; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Jimmie L. Hall
N2 - In this study, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037) was administered to 40 patients with advanced cancer in order to determine its maximum tolerated dose, to explore tolerance to repeated doses, and to make preliminary observations on its possible therapeutic effects. The initial dose of NSC-79037 was 15 mg./m.\SU/2\BS/, given orally. Progressively larger doses were given at 2 to 8 week intervals. The maximum dose was determined to be 130 mg./m.\SU/2 \BS/every 6 weeks. Nausea, vomiting, and anorexia were frequent adverse effects. One patient reported shortness of breath and swelling of the face. Thrombocytopenia and leukopenia were the most consistent dose-limiting side effects. Objective responses at toxic doses were seen in 2 of 5 patients with evaluable bronchogenic carcinoma and in both patients with malignant lymphoma. Marked neurological improvement was noted in all 3 patients with glioblastoma multiforme.
KW - 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea--effects-;
KW - Antineoplastic agents--1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea--effects, in patients with advanced cancer;
KW - Dosage--1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea--in patients with advanced cancer;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Gazdar, A. F.
AU - Beitzel, W.
AU - Talal, N.
T1 - THE AGE RELATED RESPONSES OF NEW ZEALAND MICE TO A MURINE SARCOMA VIRUS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/03//
VL - 8
IS - 3
M3 - Article
SP - 501
EP - 509
SN - 00099104
AB - The Moloney strain of murine sarcoma virus (MSV-M) rapidly induces soft tissue tumours in mice of all ages. Immunologically competent mice can spontaneously regress these tumours, and the regression time is an indication of the degree of immunologic reactivity. Using these parameters. New Zealand Black (NZB), New Zealand White × New Zealand Black F1 (B/W), and NIH Swiss mice develop cell mediated immune responses at an early age compared to five other mouse strains. 8-11-month-old NZB and B/W mice of both sexes show depressed immune responses when compared to 6-week-old controls. The responses of 10-11 month old female BALB/c mice were identical to 6-week-old controls. Older IMZB and B/W mice spontaneously develop autoimmune disease. Measurement of autoimmune parameters in the older New Zealand mouse strains indicates that immune depression precedes the onset of detectable autoimmune disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MURINE sarcoma viruses
KW - RETROVIRUSES
KW - IMMUNE response
KW - IMMUNOLOGY
KW - AUTOIMMUNE diseases
KW - TUMORS
N1 - Accession Number: 14549856; Gazdar, A. F. 1; Beitzel, W. 1; Talal, N. 1; Source Information: Mar1971, Vol. 8 Issue 3, p501; Subject: MURINE sarcoma viruses; Subject: RETROVIRUSES; Subject: IMMUNE response; Subject: IMMUNOLOGY; Subject: AUTOIMMUNE diseases; Subject: TUMORS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Vesell, E.;
AU - Page, J. G.;
AU - Passananti, T.;
T1 - Genetic and environmental factors affecting ethanol metabolism in man
CT - Genetic and environmental factors affecting ethanol metabolism in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 1)
SP - 192
EP - 201
SN - 00099236
AD - Section on Pharmacogenetics, Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0450; Language: English; Trade Name: Phenazone; Generic Name: Antipyrine; Chemical Name: Antipyrine--60-80-0; References: 35; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - The relative contribution of genetic and environmental factors to maintaining twofold differences in rates of ethanol elimination from plasma was examined in 14 sets of nonmedicated, nonhospitalized healthy twins. After a single oral dose of 1 ml./kg. of 95% ethanol, intrapair differences in rates of elimination were less in identical than in fraternal twins. These results indicate that individual differences in rates of ethanol elimination among the 28 twins were genetically controlled and that environmental factors played a negligible role. In 6 prisoners in solitary confinement, rates of ethanol metabolism increased in 3 but declined in the remaining 3 after 21 days of ethanol administration. Rates of antipyrine (phenazone) elimination from plasma were accelerated by ethanol administration in each of the 6 volunteers. Considerable individual variation occurred in the degree to which ethanol shortened plasma antipyrine half-lives; reduction ranged from 4 to 37% of the initial antipyrine half-life. These results suggest that ethanol administration for 21 days at this dosage fails to alter consistently the rate of its own metabolism but increases antipyrine metabolism in all subjects to varying extents.
KW - Antipyrine--blood levels-;
KW - Alcohols--ethyl--metabolism, genetic and environmental factors affecting, in man;
KW - Metabolism--alcohols--ethyl, genetic and environmental factors affecting, in man;
KW - Metabolism--antipyrine--blood levels, effects, ethyl alcohol, in man;
KW - Blood levels--antipyrine--effects, ethyl alcohol, in man;
KW - Half-life--antipyrine--effects, ethyl alcohol, in man;
KW - Blood levels--alcohols--ethyl, effects, genetic and environmental factors, in man;
KW - Pharmacogenetics--alcohols--ethyl, factors affecting metabolism, in man;
KW - Drug interactions--antipyrine--blood levels, effects, ethyl alcohol;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dunner, D. L.;
AU - Brodie, H. K. H.;
T1 - Plasma dopa response to levodopa administration in man: effects of a peripheral decarboxylase inhibitor
CT - Plasma dopa response to levodopa administration in man: effects of a peripheral decarboxylase inhibitor
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 1)
SP - 212
EP - 217
SN - 00099236
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0451; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 16; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - Plasma dopa levels were determined in depressed patients at various times after oral administration of levodopa with and without a peripheral decarboxylase inhibitor, D,L-alpha-methyldopa hydrazine (MK-485). Pretreatment with MK-485 caused an approximately tenfold increase in the peak plasma levels following a dopa load. Equivalent plasma levels were achieved with one-tenth the dose of levodopa with use of MK-485. A significant prolongation of the half-life of the amino acid in the plasma was also achieved. The increase of plasma dopa levels with MK-485 is in the same range as the potentiation of the clinical effect with this inhibitor.
KW - Levodopa--alone-;
KW - MK-485--and levodopa-;
KW - Drug interactions--levodopa and MK-485--potentiation, in depressed patients;
KW - Enzyme inhibitors--MK-485--potentiation, levodopa, in depressed patients;
KW - Antiparkinson agents--levodopa--alone, and with MK-485, effects, plasma dopa levels, in depressed patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
AU - Sloan, J. W.;
AU - Sapira, J. D.;
AU - Jasinski, D. R.;
T1 - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
CT - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 1)
SP - 245
EP - 258
SN - 00099236
AD - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 9-0591; Language: English; Chemical Name: Amphetamine--300-62-9 Methamphetamine--537-46-2 Ephedrine--299-42-3 Phenmetrazine--134-49-6 Methylphenidate--113-45-1; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine (28:20); AHFS Class: Central nervous system stimulants methamphetamine (28:20); AHFS Class: Central nervous system stimulants ephedrine (28:20); AHFS Class: Central nervous system stimulants phenmetrazine (28:20); AHFS Class: Central nervous system stimulants methylphenidate; References: 25; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effects of d-amphetamine, d-methamphetamine, phenmetrazine, methylphenidate, and ephedrine, on several physiologic, behavioral, and neurochemical parameters were compared in order to delineate their mode or modes of action in producing subjective reactions. All of these centrally acting sympathomimetic amines increased blood pressure and respiratory rate, produced similar types of subjective changes, and increased the excretion of epinephrine. With regard to these parameters, there was a high concordance between estimates of their relative potencies. The concordance between the potency estimates for the different parameters suggests, but does not prove, that these 5 agents share a common mode of central action. Further, if the peripheral modes of action as elucidated by animal studies are true for man, this study suggests that it is unlikely that their central actions in man are a consequence of the release of norepinephrine in the brain.
KW - Amphetamine--mechanism of action-;
KW - Methamphetamine--mechanism of action-;
KW - Ephedrine--mechanism of action-;
KW - Phenmetrazine--mechanism of action-;
KW - Methylphenidate--mechanism of action-;
KW - Central nervous system stimulants--amphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--methamphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--ephedrine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--phenmetrazine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--methylphenidate--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Mechanism of action--central nervous system stimulants--physiologic, subjective and behavioral effects, in man;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
AU - Murphy, D. L.;
AU - Brodie, H. K. H.;
AU - Bunney, W. E., Jr.;
T1 - Levodopa: alterations in behavior
CT - Levodopa: alterations in behavior
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 2)
SP - 383
EP - 396
SN - 00099236
AD - Section of Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0749; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 38; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2 - Results on the use of sustained high doses of levodopa in depressed patients are presented, and the psychiatric side effects encountered during the therapeutic use of the drug in Parkinson's disease are discussed against the background of the hypothesized role of catecholamines in the pathogenesis of affective disorders. One half of the patients were treated with smaller doses of levodopa in combination with a peripheral decarboxylase inhibitor (MK-485). Only 6 of 21 depressed patients consistently improved on levodopa, with relapse following placebo substitution and remission on restoration of the drug. A statistically significant increase in anger rating following 5 days of maximal dose of levodopa was noted as compared with that prior to treatment; others who previously experienced manic episodes manifested hypomanic behavior during treatment. Doses large enough to produce hypomania did not reverse depression. It is concluded that: (1) amine depletion does not explain the pathophysiology of depression in most patients; (2) hypomania occurs almost exclusively in affectively labile individuals; (3) the catecholamine hypothesis for depression may be an oversimplification in that mania and depression do not appear to represent the opposite poles of a single biochemical continuum; and (4) many factors contribute to psychiatric side effects\M/the pre-dopa psychiatric state being the most important variable, levodopa often serving to unmask pre-existing psychopathology.
KW - Levodopa--toxicity-;
KW - Toxicity--levodopa--side effects, psychiatric, in depressed patients following high dosage;
KW - Dosage--levodopa--high, sustained, psychiatric side effects in depressed patients;
KW - Antiparkinson agents--levodopa--side effects, psychiatric, in depressed patients following high dosage;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Eddy, N. B.;
AU - Jacobson, A. E.;
T1 - Agonists-antagonists
CT - Agonists-antagonists
JO - Curr. Med. Dialog
JF - Curr. Med. Dialog
Y1 - 1971/03/01/
VL - 38
IS - Mar
SP - 330
EP - 338
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-3164; Language: English; Chemical Name: Morphine--57-27-2; References: 36; Section Heading: Pharmacology; Abstract Author: Brenda Sue Martinez
N2 - A morphine antagonist was defined as a drug which, in at least some dosage range, can cancel or reverse morphine or morphine-like (agonist) pharmacologic effects. Certain effects of the narcotic antagonists nalorphine, levallorphan, pentazocine, and naloxone were described. For example, simultaneous administration of an agonist and an antagonist resulted in retention of analgesic effect while reducing the possibility of respiratory depression and other side effects. Based on a potency of 1.0 for nalorphine, results of animal tests for analgesic activity of agonists and antagonists were compared to the analgesia produced in man and are listed in table format. Similarly, antagonist activity of agonists and antagonists against the effect of morphine in isolated guinea pig ileum and for precipitation of withdrawal syndrome in addicted monkeys versus physical dependence liability in man were presented in another table. Naloxone, which has no significant analgesic action, no respiratory depressant or bizarre side effects, and antagonizes agonists and other antagonists, was considered a #OQ#OQpure'' antagonist.
KW - Morphine--agonists-;
KW - Narcotic antagonists--and agonists--discussion;
KW - Narcotics--discussion--of agonists and antagonists;
KW - Drugs--agonists--and antagonists, of narcotics, discussion;
KW - Analgesics and antipyretics--narcotics--discussion, of agonists and antagonists;
KW - Drug interactions--narcotics--discussion, of agonists and antagonists;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Weiss, George H.
T1 - Analysis of Binary Data (Book).
JO - Operations Research
JF - Operations Research
Y1 - 1971/03//Mar/Apr71
VL - 19
IS - 2
M3 - Book Review
SP - 552
EP - 552
PB - INFORMS: Institute for Operations Research
SN - 0030364X
AB - Reviews the book "Analysis of Binary Data," by D.R. Cox.
KW - BINARY system (Mathematics)
KW - NONFICTION
KW - COX, D. R.
KW - ANALYSIS of Binary Data (Book)
N1 - Accession Number: 8601752; Weiss, George H. 1; Affiliations: 1: National Institutes of Health Bethesda, Maryland.; Issue Info: Mar/Apr71, Vol. 19 Issue 2, p552; Subject Term: BINARY system (Mathematics); Subject Term: NONFICTION; Reviews & Products: ANALYSIS of Binary Data (Book); People: COX, D. R.; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2005-10331-006
AN - 2005-10331-006
AU - Shore, Milton F.
ED - Shore, Milton F.
T1 - The Federal Scene.
JF - Professional Psychology
JO - Professional Psychology
JA - Prof Psychol
Y1 - 1971///Spr 1971
VL - 2
IS - 2
SP - 200
EP - 201
CY - US
PB - American Psychological Association
SN - 0033-0175
N1 - Accession Number: 2005-10331-006. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shore, Milton F.; Clinical Research and Program Evaluation Section, Mental Health Study Center, National Institute of Mental Health, US. Release Date: 20060327. Correction Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Column/Opinion. Language: English. Major Descriptor: Government Agencies; Mental Health Services; Psychology; Public Sector; Scientific Communication. Classification: Professional Psychological & Health Personnel Issues (3400). Location: US. Page Count: 2. Issue Publication Date: Spr 1971. Copyright Statement: American Psychological Association. 1971.
AB - Notes that despite the major changes in the mental health field since the establishment of the National Institute of Mental Health, professional psychologists often have limited understanding of the activities on a federal level. One example is how few people are aware that the National Institute of Mental Health has had since 1948 an operating agency, the Mental Health Study Center. Professionals are also often unaware of government publications of major interest to professional psychologists, since these books and pamphlets are rarely reviewed or discussed in professional journals. Publications noted include 3 bibliographies recently published by the Government Printing Office: 1) 'Coping and Adaptation: A Behavioral Sciences Bibliography' by G. V. Coelho, D. A. Hamburg, R. Moose, and P. Randolph; 2) 'Consultation in Mental Health and Related Fields: A Reference Guide' by F. V. Mannino, described as the most complete bibliography on mental health consultation yet available; and 3) 'Bibliography on Human Intelligence' by Logan Wright. Also noted is 'Mental Health Consultation to Programs for Children: A Review of Data Collected from Selective U.S. Sites' by by S. B. McClung and A. A. Stunden. The event in Washington which most involved mental health professions at the end of 1970 was the White House Conference on Children (December 13-18, 1970). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - National Institute of Mental Health
KW - publications
KW - 1971
KW - Government Agencies
KW - Mental Health Services
KW - Psychology
KW - Public Sector
KW - Scientific Communication
KW - 1971
DO - 10.1037/h0020705
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SEMMES, JOSEPHINE
T1 - Cortical Connections.
JO - Science
JF - Science
Y1 - 1971/03/05/
VL - 171
IS - 3974
M3 - Article
SP - 885
EP - 886
SN - 00368075
N1 - Accession Number: 85104384; SEMMES, JOSEPHINE 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 3/ 5/1971, Vol. 171 Issue 3974, p885; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHENEY, D. L.
AU - GOLDSTEIN, A.
AU - ALGERI, S.
AU - COSTA, E.
T1 - Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain.
JO - Science
JF - Science
Y1 - 1971/03/19/
VL - 171
IS - 3976
M3 - Article
SP - 1169
EP - 1170
SN - 00368075
AB - Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002396; CHENEY, D. L. 1; GOLDSTEIN, A. 1; ALGERI, S. 2; COSTA, E. 2; Affiliations: 1: Department of Pharmacology, Stanford University, Stanford, California 94305; 2: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/19/1971, Vol. 171 Issue 3976, p1169; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Crane, G. E.;
T1 - Persistence of neurological symptoms due to neuroleptic drugs
CT - Persistence of neurological symptoms due to neuroleptic drugs
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1971/04/01/
VL - 127
IS - Apr
SP - 1407
EP - 1410
SN - 0002953X
AD - Psychopharmacology Research Branch, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 8-2678; Language: English; References: 12; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2 - The author examines the problem of extrapyramidal symptoms attributable to neuroleptic drugs. Thirty-nine patients with tardive dyskinesia and/or pseudoparkinsonism did not receive neuroleptics for 6 to 24 months. At the end of this time, 36 patients manifested symptoms consistent with tardive dyskinesia. In 5 of the 12 patients who had pseudoparkinsonism, alone or with tardive dyskinesia, parkinsonian symptoms persisted for 6 months or longer.
KW - Psychotherapeutic agents--toxicity studies--examination of extrapyramidal symptoms attributable to neuroleptic agents;
KW - Toxicity studies--psychotherapeutic agents--examination of extrapyramidal symptoms attributable to neuroleptic agents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Simmons, Roberta G.
AU - Rosenberg, Morris
T1 - FUNCTIONS OF CHILDREN'S PERCEPTIONS OF THE STRATIFICATION SYSTEM.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1971/04//
VL - 36
IS - 2
M3 - Article
SP - 235
EP - 249
SN - 00031224
AB - The purpose of this study has been to examine children's perceptions of the stratification system and to consider the possible consequences of these perceptions for the larger social order. There has been an attempt to extend one aspect of Davis and Moore's classical stratification theory by exploring the status attitudes requisite for an adequate number of children to strive toward prestigious, socially-important occupations. A sample of 1,917 black and white children from grades 3-12 from Baltimore City were interviewed. Findings indicate that young children have developed a type of status consciousness that should facilitate such occupational striving: that is, a clear awareness of occupational prestige differences as early as third grade (based on a comparison with 1963 adult North-Hatt ratings), and a continuing optimism about their own opportunities to achieve desirous occupations. In addition, several mechanisms are noted that appear to be dampening anger against the class system among the disadvant[a]ged school children. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL stratification
KW - SOCIAL structure
KW - PRESTIGE
KW - SOCIAL psychology
KW - SOCIAL status
KW - INTERVIEWS
KW - CHILDREN
N1 - Accession Number: 14896566; Simmons, Roberta G. 1; Rosenberg, Morris 2; Affiliations: 1 : University of Minnesota.; 2 : National Institute of Mental Health.; Source Info: Apr71, Vol. 36 Issue 2, p235; Historical Period: 1963 to 1971; Subject Term: SOCIAL stratification; Subject Term: SOCIAL structure; Subject Term: PRESTIGE; Subject Term: SOCIAL psychology; Subject Term: SOCIAL status; Subject Term: INTERVIEWS; Subject Term: CHILDREN; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
TY - GEN
AU - Morton, D. L.;
AU - Holmes, E. C.;
AU - Eilber, F. R.;
AU - Wood, W. C.;
T1 - Immunological aspects of neoplasia: a rational basis for immunotherapy
CT - Immunological aspects of neoplasia: a rational basis for immunotherapy
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/04/01/
VL - 74
IS - Apr
SP - 587
EP - 604
SN - 00034819
AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-2765; Language: English; References: 37; Publication Type: Edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Md., by the National Cancer Institute, National Institutes of Health, Department of Health, Education, and Welfare; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - During the past decade it has become increasingly apparent that cancer cells have acquired, during neoplastic transformation, new antigens not found in normal cells and that the host's immune response against these antigens is important in controlling the development and progression of malignancy. In immunologic and immunotherapeutic studies with human melanomas and sarcomas a remarkable correlation between the patient's immune response to his tumor and the extent and progression of malignant disease was found. Rising titers of antitumor antibody were consistently observed after surgical removal of the tumor mass in patients with sarcomas, whereas all patients with recurrent disease were found to have a progressive decline in their titers of antitumor antibody with advancing disease. Immunotherapy studies in guinea pigs and man have shown that active immunization with BCG vaccine and autologous tumor cells induced a heightened immune response against the tumor-associated antigens that was sometimes therapeutic.
KW - BCG vaccines--and autologous tumor cells-;
KW - Immunology--aspects--of neoplasia, a rational basis for immunotherapy;
KW - Immunization--active--with BCG vaccine and autologous tumor cells, heightened immune response against tumor-associated antigens, in guinea pigs and man, discussion;
KW - Antineoplastic agents--immunization--active, with BCG vaccine and autologous tumor cells, heightened immune response against tumor-associated antigens, in guinea pigs and man, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Paul, M. I.;
AU - Cramer, H.;
AU - Goodwin, F. K.;
T1 - Urinary cyclic AMP excretion in depression and mania
CT - Urinary cyclic AMP excretion in depression and mania
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1971/04/01/
VL - 24
IS - Apr
SP - 327
EP - 333
AD - Laboratory of Chemical Pharmacology, National Heart and Lung Institute and Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 9-4503; Language: English; Chemical Name: Lithium carbonate--554-13-2 Levodopa--59-92-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 28; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - The 24-hour urinary excretion patterns of adenosine 3', 5'-cyclic monophosphate (cyclic AMP) were examined in 40 patients with depression and/or mania and in 10 normal controls. The manic patients excreted the most cyclic AMP; when they were treated with lithium carbonate the urinary cyclic AMP diminished and their mania improved. The severely depressed patients excreted the least cyclic AMP; when 4 of them were treated with levodopa, 0.5-9 g./day, a marked increase in cyclic AMP was observed. The moderately depressed patients and control subjects excreted intermediate amounts of cyclic AMP. Consideration of various factors which may influence the urinary excretion pattern of cyclic AMP were presented.
KW - Lithium carbonate--effects-;
KW - Levodopa--effects-;
KW - Psychotherapeutic agents--lithium carbonate--effects, cyclic AMP excretion, in patients with depression or mania;
KW - Antiparkinson agents--levodopa--effects, cyclic AMP excretion, in patients with depression or mania;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cuskey, W. R.;
AU - Moffett, A. D.;
AU - Clifford, H. B.;
T1 - Comparison of female opiate addicts admitted to Lexington Hospital in 1961 and 1967
CT - Comparison of female opiate addicts admitted to Lexington Hospital in 1961 and 1967
JO - Health Serv. Rep.
JF - Health Serv. Rep.
Y1 - 1971/04/01/
VL - 86
IS - Apr
SP - 332
EP - 339
AD - reprints: Department of Community Medicine, 4219 Chester Avenue, Philadelphia, Pennsylvania 19104
AD - Clinical Research Center, National Institute of Mental Health, Lexington, Kentucky
N1 - Accession Number: 9-0289; Language: English; References: 23; Journal Coden: HSRPAT; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: Anne W. Hatch
N2 - Two groups of female opiate addicts were compared by race as well as period of admission to Lexington hospital. Level of formal education, marital status, means of support, geographical distribution, status at admission (voluntary vs. committed), age, characteristics of abuse (type of drug and progression of drugs used), treatment effectiveness and cost are discussed.
KW - Patients--addicts--opiates, female, admitted to Lexington hospital, comparison;
KW - Opiates--dependence--female, comparison, of those admitted to Lexington Hospital;
KW - Dependence--opiates--comparison of female addicts admitted to Lexington Hospital;
KW - Drug abuse--opiates--comparison, of female addicts admitted to Lexington Hospital;
KW - Costs--dependence--female opiate addicts at Lexington Hospital;
KW - Sociology--dependence--female opiate addicts, comparison, at Lexington Hospital;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Baker, P. J.
AU - Stashak, P. W.
AU - Amsbaugh, Diana F.
AU - Prescott, B.
T1 - Characterization of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level I. DOSE-RESPONSE STUDIES AND THE EFFECT OF PRIOR IMMUNIZATION ON THE MAGNITUDE OF THE ANTIBODY RESPONSE.
JO - Immunology
JF - Immunology
Y1 - 1971/04//
VL - 20
IS - 4
M3 - Article
SP - 469
EP - 480
SN - 00192805
AB - The cytokinetics of the antibody to Type III pneumococcal polysaccharide (SSS-III) were characterized by an immuno-plaque procedure using erythrocytes sensitized with SSS-III. Prior immunization, irrespective of the doses employed, did not result in the development of immunological memory; instead, low-dose paralysis was produced in mice previously immunized with all doses of SSS-III. Dose-response studies revealed that within a given dose range, there was a direct relationship between the immunizing dose and the magnitude of the antibody response obtained. The dose-response curve for SSS-III showed a single optimal dose for immunization; doses only slightly in excess of the optimal dose produced a significant reduction in the magnitude of the antibody response. The implications of these findings, with respect to the development of paralysis to SSS-III, are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - POLYSACCHARIDES
KW - IMMUNIZATION
KW - IMMUNOLOGY
KW - ERYTHROCYTES
KW - BLOOD cells
N1 - Accession Number: 13362393; Baker, P. J. 1; Stashak, P. W. 1; Amsbaugh, Diana F. 1; Prescott, B. 2; Source Information: Apr71, Vol. 20 Issue 4, p469; Subject: IMMUNOGLOBULINS; Subject: POLYSACCHARIDES; Subject: IMMUNIZATION; Subject: IMMUNOLOGY; Subject: ERYTHROCYTES; Subject: BLOOD cells; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Baker, P. J.
AU - Stashak, P. W.
AU - Amsbaugh, Diana F.
AU - Prescott, B.
T1 - Characterizaiton of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level II. STUDIES ON THE RELATIVE RATE OF ANTIBODY SYNTHESIS AND RELEASE BY ANTIBODY-PRODUCING CELLS.
JO - Immunology
JF - Immunology
Y1 - 1971/04//
VL - 20
IS - 4
M3 - Article
SP - 481
EP - 492
SN - 00192805
AB - A procedure based on the rate of appearance of plaque-forming cells (PFC) in agarose was used to measure the relative rates of antibody synthesis and release by cells making antibody specific for Type III pneumococcal polysaccharide (SSS-III). The rate of antibody synthesis and release by SSS-III-specific PFC was directly related to the immunizing dose employed; maximal values were obtained with mice given an optimally immunogenic dose (0.5 µg) of SSS-III. However, dose-dependent reductions, not only in the magnitude of the antibody response, but also in the rate of antibody synthesis and release by specific PFC, were noted in mice receiving doses greater than 0.5 µg. The latter suggests that a decrease in the rate of antibody synthesis and release by antibody-forming cells may be an initial step in the induction of immunological paralysis by high doses of SSS-III. Increases in the magnitude of the serum antibody and the PFC response were associated with corresponding increases in the rate of antibody synthesis and release by SSS-III-specific PFC following immunization; this suggests that cell differentiation—rather than proliferation—plays a major rôle in the development of the antibody response to SSS-III. In contrast, the results obtained in similar studies with sheep erythrocytes indicate that cell proliferation influences to a greater degree the magnitude of the antibody response elicited to this antigen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - POLYSACCHARIDES
KW - CELLS
KW - IMMUNOLOGY
KW - CELL proliferation
KW - IMMUNIZATION
N1 - Accession Number: 13362407; Baker, P. J. 1; Stashak, P. W. 1; Amsbaugh, Diana F. 1; Prescott, B. 2; Source Information: Apr71, Vol. 20 Issue 4, p481; Subject: IMMUNOGLOBULINS; Subject: POLYSACCHARIDES; Subject: CELLS; Subject: IMMUNOLOGY; Subject: CELL proliferation; Subject: IMMUNIZATION; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Davey, M. Jean
AU - Asherson, G. L.
AU - Stone, S. H.
T1 - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig III. DEPRESSION OF CYTOPHILIC AND HAEMOLYTIC ANTIBODIES BY PRETREATMENT WITH ANTIGEN THE EFFECT OF IRRADIATION.
JO - Immunology
JF - Immunology
Y1 - 1971/04//
VL - 20
IS - 4
M3 - Article
SP - 513
EP - 522
SN - 00192805
AB - Dvorak and Flax (1966) and others reported that adult guinea-pigs pretreated with soluble antigens showed depressed immune responses following immunization with the same antigens in Freund's complete adjuvant. These depressed immune responses included haemolytic and cytophilic antibody and delayed hypersensitivity as well as antibody measured by passive cutaneous anaphylaxis and haemagglutination. This communication describes further studies on the effect of pretreatment with alum precipitated bovine γ-globulin rather than soluble antigen. Guinea-pigs given 1 mg of alum precipitated bovine γ-globulin prior to immunization with 50 µg bovine γ-globulin (BGG) in Freund's complete adjuvant show depressed haemolytic and cytophilic antibody and delayed hypersensitivity. This depression is immunologically specific as pretreatment with alum precipitated egg albumin does not depress immune responses to bovine γ-globulin. In contrast, antibody measured by passive cutaneous anaphylaxis and haemagglutination is either unaffected or raised. Similarly, pretreatment with sheep red cells reduces the cytophilic antibody response to sheep red cells in Freund's complete adjuvant. This depression is long lasting and 1 mg alum precipitated BGG depressed the haemolytic antibody response to BGG in adjuvant given 6 months later and the delayed hypersensitivity response to BGG in adjuvant given 9 months later. Alum precipitated BGG given up to 6 days after immunization with BGG in adjuvant caused some depression of haemolytic antibody. However, this depression was transient and much less than the long lasting depression caused by pretreatment with alum precipitated BGG 7 days before immunization with BGG in adjuvant. The effect of irradiation followed by alum precipitated BGG on the immune responses to BGG in Freund's complete adjuvant was also studied. 300 r depressed haemolytic and haemagglutinating antibody but had no effect on cytophilic antibody or delayed hypersensitivity. There was no synergy between irradiation and pretreatment with BGG; the depression of immune responses caused by irradiation followed by alum precipitated BGG was no greater than the depression caused by the more effective agent when given alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - IRRADIATION
KW - IMMUNE response
KW - IMMUNITY
KW - GUINEA pigs
N1 - Accession Number: 13362443; Davey, M. Jean 1; Asherson, G. L. 1; Stone, S. H. 1; Source Information: Apr71, Vol. 20 Issue 4, p513; Subject: IMMUNOGLOBULINS; Subject: ANTIGENS; Subject: IRRADIATION; Subject: IMMUNE response; Subject: IMMUNITY; Subject: GUINEA pigs; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Steinberg, Alfred D.
AU - Pincus, Theodore
AU - Talal, Norman
T1 - The Pathogenesis of Autoimmunity in New Zealand Mice III. FACTORS INFLUENCING THE FORMATION OF ANTI-NUCLEIC ACID ANTIBODIES.
JO - Immunology
JF - Immunology
Y1 - 1971/04//
VL - 20
IS - 4
M3 - Article
SP - 523
EP - 531
SN - 00192805
AB - The synthetic double stranded ribonucleic acids rI·rC and rA·rU were found to be immunogenic in normal mice when given without a protein carrier in Freund's complete adjuvant. When RNA was given without adjuvant, antibody could be detected only in New Zealand mice. Greater quantities of antibody were produced by females than males as in spontaneous disease. Sexual alteration did not alter this pattern. Spontaneous antibodies to RNA appeared before antibodies to DNA in NZB/ NZW mice, suggesting that a naturally occurring double stranded RNA may be a major factor in the spontaneous production of anti-nucleic acid antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNITY
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGICAL adjuvants
KW - RNA
KW - DNA
KW - MICE
KW - NEW Zealand
N1 - Accession Number: 13362464; Steinberg, Alfred D. 1; Pincus, Theodore 1; Talal, Norman 1; Source Information: Apr71, Vol. 20 Issue 4, p523; Subject: AUTOIMMUNITY; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGICAL adjuvants; Subject: RNA; Subject: DNA; Subject: MICE; Geographic Terms: NEW Zealand; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2013-41269-013
AN - 2013-41269-013
AU - Ryder, Robert G.
AU - Kafka, John S.
AU - Olson, David H.
T1 - Separating and joining influences in courtship and early marriage.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1971/04//
VL - 41
IS - 3
SP - 450
EP - 464
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Ryder, Robert G., Section on Family Development, Child Research Branch, National Institute of Mental Health, Building 1 5-K, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-41269-013. PMID: 5549916 Partial author list: First Author & Affiliation: Ryder, Robert G.; Section on Family Development, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Courtship; Life Changes; Marriage; Social Processes. Minor Descriptor: Early Experience; Social Interaction. Classification: Marriage & Family (2950). Population: Human (10). References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1971.
AB - Transitional processes, such as getting married, are described in terms of the interaction of change-facilitating and change-resisting social forces. Lawful features of a transitional process include a non-arbitrary sequence of stages defined by reversals in the influence of particular classes of third party events. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - courtship
KW - early marriage
KW - life transition
KW - social interaction
KW - social processes
KW - 1971
KW - Human Courtship
KW - Life Changes
KW - Marriage
KW - Social Processes
KW - Early Experience
KW - Social Interaction
KW - 1971
DO - 10.1111/j.1939-0025.1971.tb01131.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GIELEN, J. E.
AU - NEBERT, D. W.
T1 - Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p,p'-DDT.
JO - Science
JF - Science
Y1 - 1971/04/09/
VL - 172
IS - 3979
M3 - Article
SP - 167
EP - 169
SN - 00368075
AB - Aryl hydrocarbon hydroxylase induction hy phenoharhital, polycyclic hydrocarhons, and the insecticide, 2.2-bis(p-chlorophenyl)-1,1,1-trichloroethane(p,p'-DDT), occurs in rat fetal liver cell cultures. The maxinuun net rate at which the hydroxylase activity accumulates is about the same when phenobarbital, 3-methylcholanthrene, or benz[a]anthracene is in the growth medium at optimum concentrations. An additive effect is obtained when either phenoharhital or p,p'DDT is present with a polycyclic hYdrocarbon in the growth medium, but not when the cells are treated with phenoharhital plus p,p'-DDT or with the combination of two polycyclic hydrocarhons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104483; GIELEN, J. E. 1; NEBERT, D. W. 1,2; Affiliations: 1: Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health, Bethesda, Maryland 20014; 2: Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 9/1971, Vol. 172 Issue 3979, p167; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BRADY, ROSCOE O.
AU - UHLENDORF, B. WILLIAM
AU - JACOBSON, CECIL B.
T1 - Fabry's Disease: Antenatal Detection.
JO - Science
JF - Science
Y1 - 1971/04/09/
VL - 172
IS - 3979
M3 - Article
SP - 174
EP - 175
SN - 00368075
AB - A procedure is described for the intrauterine detection, at the 17th week of gestation, of a male fetus afflicted with Fabry's disease. The validity of this determination was substantiated by multiple enzyme and lipid analyses of tissue specimens obtained from the afflicted fetus. Fabry's disease may now be included with other X-linked metabolic deficiency diseases that are amenable to precise genetic counseling, through carrier identification, and the monitoring of ensuing pregnancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104486; BRADY, ROSCOE O. 1; UHLENDORF, B. WILLIAM 2; JACOBSON, CECIL B. 3; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Neurological Diseases and Blindness, Bethesda, Maryland 20014; 2: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Obstetrics and Gynecology, George Washington University School of Medicine, Washington, D.C. 20005; Issue Info: 4/ 9/1971, Vol. 172 Issue 3979, p174; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZBAR, BERTON
AU - TANAKA, TOMIKO
T1 - Immunotherapy of Cancer: Regression of Tumors after Intralesional Injection of Living Mycobacterium bovis.
JO - Science
JF - Science
Y1 - 1971/04/16/
VL - 172
IS - 3980
M3 - Article
SP - 271
EP - 273
SN - 00368075
AB - Injection of living Mycobacterium bovis (strain BCG) into established intradermal tumors caused tumor regression and prevented the development of metastases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87499068; ZBAR, BERTON 1; TANAKA, TOMIKO 1; Affiliations: 1: Cellular Immunity Section, Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/16/1971, Vol. 172 Issue 3980, p271; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Larson, H. E.;
AU - Parkman, P. D.;
AU - Davis, W. J.;
AU - Hopps, H. E.;
AU - Meyer, H. M.;
T1 - Inadvertent rubella virus vaccination during pregnancy
CT - Inadvertent rubella virus vaccination during pregnancy
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/04/22/
VL - 284
IS - Apr 22
SP - 870
EP - 873
SN - 00284793
AD - Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 9-1182; Language: English; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2 - Studies concerning 9 pregnant women inadvertently inoculated with live rubella virus vaccine confirmed that the attenuated virus can produce chronic placental infection. None of the women had been tested for rubella susceptibility before vaccination; however, serologic testing of later serum specimens indicated seroconversion of one. This subject and one other reported symptoms consistent with vaccine-virus infection. In both women the attenuated virus was isolated from conceptuses collected 69 and 28 days respectively after immunization. Attempts at virus isolation were negative on specimens from the remaining 6 women. Histologic changes in placenta or decidua consistent with rubella infection were detected in the 2 virus-positive cases and in one negative case. These data underscore the need for caution in vaccinating postpubertal women.
KW - Rubella vaccines--toxicity-;
KW - Toxicity--rubella vaccines--inadvertent live virus vaccination results in chronic placental infection, in women;
KW - Placental transfer--rubella vaccines--chronic placental infection in mothers inadvertently receiving live virus vaccine during pregnancy;
KW - Metabolism--rubella vaccines--placental transfer, results in chronic placental infection due to inadvertent live virus vaccination, in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Henkin, R. I.;
AU - Smith, F. R.;
T1 - Hyposmia in acute viral hepatitis
CT - Hyposmia in acute viral hepatitis
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1971/04/24/
VL - 1
IS - Apr 24
SP - 823
EP - 826
SN - 00237507
AD - Section on Neuroendocrinology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-1265; Language: English; Chemical Name: Pyridine--100-86-1 Nitrobenzene--98-95-3 Thiophene--110-02-1; References: 15; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Nineteen patients with acute viral hepatitis have been found to have decreased olfactory acuity (hyposmia) which is associated with dysosmia and dysgeusia. Olfactory acuity was measured with 3 vapors\M/pyridine in water and nitrobenzene and thiophene in mineral oil. Hyposmia, called type-II hyposmia, lessened as the illness subsided. Improvement in olfactory acuity was inversely related to the plasma bilirubin and directly related to the plasma retinol binding protein level. Abnormalities of olfaction and taste may be major factors in the anorexia of hepatitis. Measurement of olfactory acuity is a rapid, simple means of assessing and monitoring hepatic function.
KW - Pyridine--vapors-;
KW - Nitrobenzene--vapors-;
KW - Thiophene--vapors-;
KW - Tests--olfactory--in patients with acute viral hepatitis;
KW - Smell--tests--olfactory acuity measured in patients with acute viral hepatitis;
KW - Methodology--measurement of olfactory acuity--in patients with acute viral hepatitis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Chrambach, A.
AU - Rodbard, D.
T1 - Polyacrylamide Gel Electrophoresis.
JO - Science
JF - Science
Y1 - 1971/04/30/
VL - 172
IS - 3982
M3 - Article
SP - 440
EP - 451
SN - 00368075
N1 - Accession Number: 85104536; Chrambach, A. 1; Rodbard, D. 1; Affiliations: 1: Senior investigator, Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p440; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NG, K. Y.
AU - CHASE, T. N.
AU - COLBURN, R. W.
AU - KOPIN, I. J.
T1 - Dopamine: Stimulation-Induced Release from Central Neurons.
JO - Science
JF - Science
Y1 - 1971/04/30/
VL - 172
IS - 3982
M3 - Article
SP - 487
EP - 489
SN - 00368075
AB - Dopamine, synthesized in rat brain slices from labeled L-tyrosine or L-dopa, can be released by electrical stimulation of a type known to induce neuronal depolarization. Pretreatment of the animals with 6-hydroxydopamine, which destroys central catecholamine-containing nerve terminals, substantially reduced the release of dopamine synthesized from [14C]tyrosine or from a low concentration of [³H]dopa, whereas the release of dopamine formed from a high concentration of [³H]dopa remained essentially unchanged. The observations that at high concentrations L-dopa may enter noncatecholaminergic cells, undergo decarboxylation to dopamine, and subsequently be liberated in response to depolarization suggest that dopamine may act as a substitute central transmitter, possibly in serotonergic neurons. This mechanism may contribute to L-dopa's clinical effects in parkinsonian patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104558; NG, K. Y. 1; CHASE, T. N. 1; COLBURN, R. W. 1; KOPIN, I. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p487; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Carter Jr., Jerry W.
T1 - THE COMMUNITY SERVICES PROGRAM OF THE NATIONAL INSTITUTE OF MENTAL HEALTH, U. S. PUBLIC HEALTH SERVICE.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1950/04//
VL - 6
IS - 2
M3 - Article
SP - 112
EP - 117
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article reports on the community services program of the national institute of mental health, U. S. public health service. Following World War II, congressional hearings revealed that various mental and emotional disorders and inadequacies accounted for the rejection or discharge of 2,000,000 men by the armed services. It was found that more than half of the patients hospitalized in the United States on any given day--some 600,000--were mental patients, and that about 8,000,000 individuals in the country were suffering from some mental disorder. No adequate programs for the prevention and early treatment of mental illness existed anywhere in the country. A National Advisory Mental Health Council consisting of leading scientific and medical authorities is provided for in the National Mental Health Act. This body advises the Surgeon General on such matters as policy, the distribution of grant funds, personnel standards, and other problems relating to the program.
KW - MENTALLY ill -- Care
KW - MENTAL health
KW - NATIONAL health services
KW - HUMAN services
KW - PUBLIC health
KW - MENTALLY ill
KW - UNITED States
N1 - Accession Number: 15828812; Carter Jr., Jerry W. 1; Affiliation: 1: Chief Clinical Psychologist, Community Services Branch, National institute of Mental Health, U. S. Public Health Service.; Source Info: Apr1950, Vol. 6 Issue 2, p112; Subject Term: MENTALLY ill -- Care; Subject Term: MENTAL health; Subject Term: NATIONAL health services; Subject Term: HUMAN services; Subject Term: PUBLIC health; Subject Term: MENTALLY ill; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perkins, Keith J.
T1 - THE OPPORTUNITIES AND RESPONSIBILITIES OF CLINICAL PSYCHOLOGY IN THE FIELD OF COMMUNITY SERVICES.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1950/04//
VL - 6
IS - 2
M3 - Article
SP - 117
EP - 121
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses the opportunities and responsibilities of clinical psychology in the field of community services. The clinical psychologist working in the traditional setting of the clinic or hospital is accustomed to having his cases brought to him in his own office where he usually works with them on an individual basis. Another way in which community work differs from work in the usual clinic setting is that the psychologist associates with different groups of workers. Most clinical psychologists have worked only with psychiatrists and social workers whose approach to problems is similar to theirs. Since other workers in the community often have rather vague concepts of the mental health specialties, they are apt to confuse their functions. If the psychologist is also confused, the situation will be all the more complicated.
KW - CLINICAL psychology
KW - PSYCHOLOGY
KW - APPLIED psychology
KW - MENTAL health personnel
KW - MEDICAL personnel
KW - PSYCHOLOGICAL tests
N1 - Accession Number: 15828813; Perkins, Keith J. 1; Affiliation: 1: Clinical Psychologist, Phoenix Mental Health Center, National Institute of Mental Health, U. S. P. H. S.; Source Info: Apr1950, Vol. 6 Issue 2, p117; Subject Term: CLINICAL psychology; Subject Term: PSYCHOLOGY; Subject Term: APPLIED psychology; Subject Term: MENTAL health personnel; Subject Term: MEDICAL personnel; Subject Term: PSYCHOLOGICAL tests; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shock, Nathan W.
T1 - GERONTOLOGY (LATER MATURITY).
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1951/02//
VL - 2
IS - 1
M3 - Article
SP - 353
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11290999; Shock, Nathan W. 1; Affiliation: 1: National Heart Institute, National Institutes of Health; Source Info: 1951, Vol. 2 Issue 1, p353; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bailey, Pearce
T1 - Relationship and Research and Education in a National Program for Handicapped Children.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1954/04//
VL - 20
IS - 7
M3 - Article
SP - 289
EP - 293
SN - 00144029
AB - The article discusses the relationship between research on neurological and sensory disorders and education of exceptional children. The growth of services for the exceptional child has been paralleled by the growth of research devoted to the prevention, diagnosis and treatment of the disorders which demand the services. The aim is to eliminate blindness, deafness, cerebral palsy, epilepsy and other disorders which create the exceptional child. Scientists are attempting to find the biological basis for functions such as perception, learning and memory. Research, education and rehabilitation may have an opportunity to work together.
KW - EXCEPTIONAL children
KW - SPECIAL education
KW - MEDICAL research
KW - DISABILITY evaluation
KW - DIAGNOSIS
KW - MEDICAL rehabilitation
KW - SENSORY disorders in children
KW - PERCEPTUAL disorders
KW - COGNITIVE learning
N1 - Accession Number: 19788665; Bailey, Pearce 1; Affiliation: 1: Director of the National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, US Department of Health; Source Info: Apr1954, Vol. 20 Issue 7, p289; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: MEDICAL research; Subject Term: DISABILITY evaluation; Subject Term: DIAGNOSIS; Subject Term: MEDICAL rehabilitation; Subject Term: SENSORY disorders in children; Subject Term: PERCEPTUAL disorders; Subject Term: COGNITIVE learning; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carlson, V. R.
T1 - Individual Differences in the Recall of Word-Association-Test Words.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1954/09//
VL - 23
IS - 1
M3 - Article
SP - 77
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8946506; Carlson, V. R. 1; Affiliation: 1: National Institutes of Health, Institute of Mental Health, Bethesda, Maryland.; Source Info: Sep54, Vol. 23 Issue 1, p77; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1467-6494.ep8946506
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Radke-Yarrow, Marian
AU - Yarrow, Leon J.
T1 - CHILD PSYCHOLOGY.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1955/02//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 28
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 17741202; Radke-Yarrow, Marian 1 Yarrow, Leon J. 2; Affiliation: 1: Laboratory of Socio-Environmental Studies, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland. 2: Family and Child Services of Washington, D. C., Washington, D. C.; Source Info: 1955, Vol. 6 Issue 1, p1; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bayley, Nancy
T1 - INDIVIDUAL PATTERNS OF DEVELOPMENT.
JO - Child Development
JF - Child Development
Y1 - 1956/03//
VL - 27
IS - 1
M3 - Article
SP - 45
EP - 74
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12634131; Bayley, Nancy 1; Affiliation: 1: National Institute of Mental Health; Source Info: Mar1956, Vol. 27 Issue 1, p45; Number of Pages: 30p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saslow, George
AU - Goodrich, D. W.
AU - Stein, Marvin
T1 - STUDY OF THERAPIST BEHAVIOR IN DIAGNOSTIC INTERVIEWS BY MEANS OF THE INTERACTION CHRONOGRAPH.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1956/04//
VL - 12
IS - 2
M3 - Article
SP - 133
EP - 139
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses the study of therapist behavior. An important aspect of the operation of clinics which evaluate the probable response of patients to behavior therapy is the diagnostic interview of the patient by an experienced staff member. An attempt is made in such an interview to decide various questions, such as the nature of the disabilities present, the need for further examinations or referrals, the wisdom of the referral to this particular clinic, the probable response of the patient to behavior therapy, the indicated major areas to work on in behavior therapy, the therapist most likely to be effective, etc.
KW - PSYCHOTHERAPIST & patient
KW - PSYCHOTHERAPY
KW - BEHAVIOR modification
KW - BEHAVIOR therapy
KW - HEALTH facilities
KW - DISABILITIES
N1 - Accession Number: 15845390; Saslow, George 1 Goodrich, D. W. 2 Stein, Marvin 3; Affiliation: 1: Massachusetts General Hospital and Harvard Medical School, University of Pennsylvania. 2: National Institute of Mental Health, University of Pennsylvania. 3: University of Pennsylvania.; Source Info: Apr1956, Vol. 12 Issue 2, p133; Subject Term: PSYCHOTHERAPIST & patient; Subject Term: PSYCHOTHERAPY; Subject Term: BEHAVIOR modification; Subject Term: BEHAVIOR therapy; Subject Term: HEALTH facilities; Subject Term: DISABILITIES; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Belleville, Richard E.
T1 - MMPI SCORE CHANGES INDUCED BY LYSERGIC ACID DIETHYLAMIDE (LSD-25).
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1956/07//
VL - 12
IS - 3
M3 - Article
SP - 279
EP - 282
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article investigates some of the psychological effects of Lysergic Acid Diethylamide (LSD-25) and evaluates the MMPI as an instrument for measuring personality changes produced by pharmaceutical agents. Twenty-four former narcotic addicts were given the MMPI under control, placebo and LSD conditions. The greatest increase following LSD was obtained on the Sc scale, since this scale measures the extent to which patients deviate from conventional ways of thinking and reacting and since the LSD syndrome has been compared frequently with schizophrenia.
KW - LSD (Drug)
KW - MINNESOTA Multiphasic Personality Inventory
KW - PERSONALITY tests
KW - DRUG addicts
KW - PLACEBOS (Medicine)
KW - SCHIZOPHRENIA
N1 - Accession Number: 15845482; Belleville, Richard E. 1; Affiliation: 1: The National Institute of Mental Health Addiction Research Center, USPHS Hospital Lexington, Kentucky.; Source Info: Jul1956, Vol. 12 Issue 3, p279; Subject Term: LSD (Drug); Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: PERSONALITY tests; Subject Term: DRUG addicts; Subject Term: PLACEBOS (Medicine); Subject Term: SCHIZOPHRENIA; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gewirtz, Jacob L.
AU - Baer, Donald M.
AU - Roth, Chaya H.
T1 - A NOTE ON THE SIMILAR EFFECTS OF LOW SOCIAL AVAILABILITY OF AN ADULT AND BRIEF SOCIAL DEPRIVATION ON YOUNG CHILDREN'S BEHAVIOR.
JO - Child Development
JF - Child Development
Y1 - 1958/03//
VL - 29
IS - 1
M3 - Article
SP - 149
EP - 152
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12279985; Gewirtz, Jacob L. 1 Baer, Donald M. 2 Roth, Chaya H. 3; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health 2: University of Washington 3: University of Chicago; Source Info: Mar1958, Vol. 29 Issue 1, p149; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosvold, H.Enger
T1 - PHYSIOLOGICAL PSYCHOLOGY.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1959/02//
VL - 10
IS - 1
M3 - Article
SP - 415
EP - 454
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11290181; Rosvold, H.Enger 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health Bethesda, Maryland.; Source Info: 1959, Vol. 10 Issue 1, p415; Number of Pages: 40p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobson, Stanley
AU - Faegre, Christopher
T1 - NEUTRALIZATION: A Tool for the teacher of DISTURBED CHILDREN.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1959/02//
VL - 25
IS - 6
M3 - Article
SP - 243
EP - 246
SN - 00144029
AB - The article considers the concept of neutralization as a useful tool for teachers of disturbed children. Neutralization means freeing the child's area of problem that depends on those personality characteristics in which he happens to be weakest. The schools are planning for disturbed children by providing special counseling and referral services. It is suggested that neutralization can be considered an additional classroom tool to minimize the influence of personality problems on the learning process of disturbed children.
KW - MENTALLY ill children -- Education
KW - PERSONALITY in children
KW - TEACHING aids & devices
KW - EXCEPTIONAL children
KW - SPECIAL education
KW - LEARNING
KW - CHILDREN -- Services for
KW - TEACHERS
KW - EDUCATIONAL programs
KW - EDUCATIONAL standards
N1 - Accession Number: 19807885; Jacobson, Stanley 1 Faegre, Christopher 2; Affiliation: 1: Educational specialist, Child Research Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 2: Teacher, Remedial Child Research Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; Source Info: Feb1959, Vol. 25 Issue 6, p243; Subject Term: MENTALLY ill children -- Education; Subject Term: PERSONALITY in children; Subject Term: TEACHING aids & devices; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: LEARNING; Subject Term: CHILDREN -- Services for; Subject Term: TEACHERS; Subject Term: EDUCATIONAL programs; Subject Term: EDUCATIONAL standards; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Little, Kenneth B.
T1 - Connotations of the Rorschach inkblots.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1959/09//
VL - 27
IS - 3
M3 - Article
SP - 397
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8946421; Little, Kenneth B. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Sep59, Vol. 27 Issue 3, p397; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1467-6494.ep8946421
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8946421&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haertzen, Charles A.
AU - Hill, Harris E.
T1 - EFFECTS OF MORPHINE AND PENTOBARBITAL ON DIFFERENTIAL MMPI PROFILES.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1959/10//
VL - 15
IS - 4
M3 - Article
SP - 434
EP - 437
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses the effects of morphine and pentobarbital on differential MMPI profiles. Evidence that altering certain incentives modifies the behavioral effects of morphine and pentobarbital was presented in a previous report. The present study was similar in formulation but was specifically concerned with possible core relations between drug effects and personality characteristics as measured by the MMPI. That this inventory may be useful in assessing drug effects has been demonstrated. No mention was made in these reports of a possible interaction between personality and drug effect.
KW - DRUGS -- Physiological effect
KW - MORPHINE
KW - PENTOBARBITAL
KW - PERSONALITY
KW - INVENTORIES
KW - DRUGS -- Effectiveness
N1 - Accession Number: 15847207; Haertzen, Charles A. 1 Hill, Harris E. 1; Affiliation: 1: National Institute of Mental Health, Addiction Research Center, PHS, Lexington, Kentucky.; Source Info: Oct1959, Vol. 15 Issue 4, p434; Subject Term: DRUGS -- Physiological effect; Subject Term: MORPHINE; Subject Term: PENTOBARBITAL; Subject Term: PERSONALITY; Subject Term: INVENTORIES; Subject Term: DRUGS -- Effectiveness; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Birren, James E.
T1 - PSYCHOLOGICAL ASPECTS OF AGING.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1960/02//
VL - 11
IS - 1
M3 - Article
SP - 161
EP - 198
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11266867; Birren, James E. 1; Affiliation: 1: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p161; Number of Pages: 38p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubenstein, Herbert
AU - Aborn, Murray
T1 - PSYCHOLINGUISTICS.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1960/02//
VL - 11
IS - 1
M3 - Article
SP - 291
EP - 322
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11267426; Rubenstein, Herbert 1 Aborn, Murray 2; Affiliation: 1: Operational Applications Laboratory, Air Forte Cambridge Research Center, Bedford, Massachusetts. 2: Division of Research Grants, National Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p291; Number of Pages: 32p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ross, Sherman
AU - Cole, Jonathan 0.
T1 - PSYCHOPHARMACOLOGY.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1960/02//
VL - 11
IS - 1
M3 - Article
SP - 415
EP - 438
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11267444; Ross, Sherman 1 Cole, Jonathan 0. 2; Affiliation: 1: University of Maryland, College Park, Maryland. 2: Psychopharmacology Service center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.; Source Info: 1960, Vol. 11 Issue 1, p415; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenthal, David
AU - Lawlor, William G.
AU - Zahn, Theodore P.
AU - Shakow, David
T1 - The relationship of some aspects of mental set to degree of schizophrenic disorganization.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1960/03//
VL - 28
IS - 1
M3 - Article
SP - 26
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8931052; Rosenthal, David 1 Lawlor, William G. 1,2 Zahn, Theodore P. 1 Shakow, David 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health. 2: Assistant Professor of Psychology, Fordham University.; Source Info: Mar60, Vol. 28 Issue 1, p26; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1467-6494.ep8931052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8931052&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Richard H.
T1 - Mental Health Manpower Trends (Book).
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1960///Summer1960
VL - 1
IS - 2
M3 - Book Review
SP - 142
EP - 143
SN - 00959006
AB - Reviews the book "Mental Health Manpower Trends," by George W. Albee.
KW - MENTAL health
KW - NONFICTION
KW - ALBEE, George W.
KW - MENTAL Health Manpower Trends: A Report to the Staff Director, Jack R. Ewalt: 1959 (Book)
N1 - Accession Number: 15444107; Williams, Richard H. 1; Affiliation: 1: National Institute of Mental Health; Source Info: Summer1960, Vol. 1 Issue 2, p142; Subject Term: MENTAL health; Subject Term: NONFICTION; Reviews & Products: MENTAL Health Manpower Trends: A Report to the Staff Director, Jack R. Ewalt: 1959 (Book); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); People: ALBEE, George W.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Richard Q.
T1 - RELATIONS BETWEEN BEHAVIOR MANIFESTATIONS IN THE HUMAN NEONATE.
JO - Child Development
JF - Child Development
Y1 - 1960/09//
VL - 31
IS - 3
M3 - Article
SP - 463
EP - 477
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 16288998; Bell, Richard Q. 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health, National Institute of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland; Source Info: Sep1960, Vol. 31 Issue 3, p463; Number of Pages: 15p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rheingold, Harriet L.
T1 - THE MEASUREMENT OF MATERNAL CARE.
JO - Child Development
JF - Child Development
Y1 - 1960/09//
VL - 31
IS - 3
M3 - Article
SP - 565
EP - 575
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 16289075; Rheingold, Harriet L. 1; Affiliation: 1: National Institute of Mental Health; Source Info: Sep1960, Vol. 31 Issue 3, p565; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Syme, S. Leonard
T1 - Thirty Years of Research in Human Fertility -- Retrospect and Prospect (Book).
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1960///Winter1960
VL - 1
IS - 4
M3 - Book Review
SP - 321
EP - 322
SN - 00959006
AB - Reviews the book "Thirty Years of Research in Human Fertility: Retrospect and Prospect."
KW - FERTILITY
KW - NONFICTION
KW - 30 Years of Research in Human Fertility: Retrospect & Prospect (Book)
N1 - Accession Number: 15176986; Syme, S. Leonard 1; Affiliation: 1: National Institutes of Health.; Source Info: Winter1960, Vol. 1 Issue 4, p321; Subject Term: FERTILITY; Subject Term: NONFICTION; Reviews & Products: 30 Years of Research in Human Fertility: Retrospect & Prospect (Book); Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Suster, E.
AU - Kirsanow, Eugene M.
T1 - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions.
JO - Immunology
JF - Immunology
Y1 - 1961/10//
VL - 4
IS - 4
M3 - Article
SP - 354
EP - 365
PB - Wiley-Blackwell
SN - 00192805
AB - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - IMMUNE response
KW - MYCOBACTERIA
KW - BACTERIAL toxins
KW - ANTIGEN-antibody reactions
KW - MICE as carriers of disease
KW - IMMUNOLOGY
N1 - Accession Number: 12534120; Suster, E. 1,2 Kirsanow, Eugene M. 1,2; Affiliation: 1: Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida, U.S.A. 2: National Institute of Allergy and Infectious Diseases, National Institute of Health, United States Public Health Service; Source Info: Oct61, Vol. 4 Issue 4, p354; Subject Term: ENDOTOXINS; Subject Term: IMMUNE response; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL toxins; Subject Term: ANTIGEN-antibody reactions; Subject Term: MICE as carriers of disease; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cromwell, Rue L.
AU - Rosenthal, David
AU - Shakow, David
AU - Zahn, Theodore P.
T1 - Reaction time, locus of control, choice behavior, and descriptions of parental behavior in schizophrenic and normal subjects.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1961/12//
VL - 29
IS - 4
M3 - Article
SP - 363
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8933354; Cromwell, Rue L. 1 Rosenthal, David 2 Shakow, David 2 Zahn, Theodore P. 2; Affiliation: 1: George Peabody College for Teachers. 2: National Institute of Mental Health.; Source Info: Dec61, Vol. 29 Issue 4, p363; Number of Pages: 17p; Document Type: Article
L3 - 10.1111/1467-6494.ep8933354
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8933354&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manne, Sigmund H.
AU - Kandel, Arthur
AU - Rosenthal, David
T1 - DIFFERENCES BETWEEN PERFORMANCE IQ AND VERBAL IQ IN A SEVERELY SOCIOPATHIC POPULATION.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1962/01//
VL - 18
IS - 1
M3 - Article
SP - 73
EP - 77
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article reports that studies of the relationship between Performance IQ and Verbal IQ in the sociopath have resulted in contradictory findings. The operational definition of sociopath used was a behavioral one: the experimental subjects were a group of 112 sex offenders all of whom, at the time of examination, already had been convicted in a court of sexual crime against another person sent to the Oregon State Hospital for psychiatric and psychological examination. Ss were 193 defective delinquents committed to Maryland's Patuxent Institution for diagnosis and treatment.
KW - INTELLIGENCE levels
KW - ANTISOCIAL personality disorders
KW - PERSONALITY disorders
KW - ANTINOMIAN personality
KW - PUBLIC hospitals
KW - OREGON
N1 - Accession Number: 15828168; Manne, Sigmund H. 1 Kandel, Arthur 1 Rosenthal, David 2; Affiliation: 1: Patuxent Institution, Jessup, Maryland. 2: National Institute of Mental Health.; Source Info: Jan1962, Vol. 18 Issue 1, p73; Subject Term: INTELLIGENCE levels; Subject Term: ANTISOCIAL personality disorders; Subject Term: PERSONALITY disorders; Subject Term: ANTINOMIAN personality; Subject Term: PUBLIC hospitals; Subject Term: OREGON; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hollister, William C.
AU - Coldston, Stephen E.
T1 - Psychoeducational Processes in Classes for Emotionally Handicapped Children.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1962/03//
VL - 28
IS - 7
M3 - Article
SP - 351
EP - 356
SN - 00144029
AB - The article evaluates the psychoeducational processes in classes for emotionally handicapped children. The authors reviewed and analyzed a sample of program description from schools in the U.S. that are currently giving classes for emotionally handicapped children, and gathered the data from existing reports into a beginning taxonomy of the procedures and considerations involved in conducting classes for emotionally handicapped children. In this article, the researchers found that there is a need for some elderly classification of the various psychoeducational processes.
KW - CHILDREN with disabilities -- Education
KW - EXCEPTIONAL children
KW - SPECIAL education
KW - CHILD psychology
KW - CHILD development
KW - MENTAL health
KW - PSYCHOLOGY of learning
KW - EDUCATION -- United States
KW - UNITED States
N1 - Accession Number: 19680994; Hollister, William C. 1 Coldston, Stephen E. 2; Affiliation: 1: Consultant, Mental Health in Education, Community Services Branch, National Institute of Mental Health, Bethesda 2: Chief, Mental Health Education Unit of the New York City Community Mental Health Board, New York; Source Info: Mar1962, Vol. 28 Issue 7, p351; Subject Term: CHILDREN with disabilities -- Education; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: CHILD psychology; Subject Term: CHILD development; Subject Term: MENTAL health; Subject Term: PSYCHOLOGY of learning; Subject Term: EDUCATION -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schooler, Carmi
AU - Scarr, Sandra
T1 - Affiliation among chronic schizophrenics: relation to intrapersonal and birth order factors.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1962/06//
VL - 30
IS - 2
M3 - Article
SP - 178
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8932610; Schooler, Carmi 1 Scarr, Sandra 2; Affiliation: 1: National Institute of Mental Health. 2: Radcliffe College.; Source Info: Jun62, Vol. 30 Issue 2, p178; Number of Pages: 15p; Document Type: Article
L3 - 10.1111/1467-6494.ep8932610
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bower, Eli M.
T1 - The Role of Schools in Mental Health.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1962/12//
VL - 29
IS - 4
M3 - Book Review
SP - 197
EP - 198
SN - 00144029
AB - The article reviews the book "The Role of Schools in Mental Health," by Wesley Allinsmith and George W. Goethals.
KW - MENTAL health education
KW - NONFICTION
KW - ALLINSMITH, Wesley
KW - GOETHALS, George W. (George Washington), 1858-1928
KW - ROLE of Schools in Mental Health, The (Book)
N1 - Accession Number: 19707003; Bower, Eli M. 1; Affiliation: 1: Consultant, Mental Health in Education, Community Services Branch, National Institute of Mental Health, Bethesda, Maryland; Source Info: Dec1962, Vol. 29 Issue 4, p197; Subject Term: MENTAL health education; Subject Term: NONFICTION; Reviews & Products: ROLE of Schools in Mental Health, The (Book); People: ALLINSMITH, Wesley; People: GOETHALS, George W. (George Washington), 1858-1928; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manne, Sigmund H.
AU - Kandel, Arthur
AU - Rosenthal, David
T1 - THE RELATIONSHIP BETWEEN PERFORMANCE MINUS VERBAL SCORES AND EXTRAVERSION IN A SEVERELY SOCIOPATHIC POPULATION.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1963/01//
VL - 19
IS - 1
M3 - Article
SP - 96
EP - 97
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents the relationship between performance intelligence quotient (IQ) minus verbal IQ scores and extraversion in a severely sociopathic population. One hundred inmates who had been admitted to the Patuxent Institution were given the Maudsley Personality Inventory, which is designed to measure two orthogonal factors: Extraversion-Introversion and Neuroticism. The Wechsler-Bellevue Intelligence Scale, Form I, is given routinely to all new admissions to Patuxent Institution as part of the diagnostic evaluation. The negative correlation barely misses significance at the .05 levels, and is in the opposite direction from the one predicted by the hypothesis.
KW - ANTISOCIAL personality disorders
KW - INTELLIGENCE levels
KW - WECHSLER Adult Intelligence Scale
KW - PERSONALITY tests
KW - MAUDSLEY personality inventory
KW - EXTRAVERSION
KW - INTROVERSION
N1 - Accession Number: 15844061; Manne, Sigmund H. 1 Kandel, Arthur 1 Rosenthal, David 2; Affiliation: 1: Patuxent Institution, Jessup, Maryland. 2: National Institute of Mental Health.; Source Info: Jan1963, Vol. 19 Issue 1, p96; Subject Term: ANTISOCIAL personality disorders; Subject Term: INTELLIGENCE levels; Subject Term: WECHSLER Adult Intelligence Scale; Subject Term: PERSONALITY tests; Subject Term: MAUDSLEY personality inventory; Subject Term: EXTRAVERSION; Subject Term: INTROVERSION; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rheingold, Harriet L.
AU - Stanley, Walter C.
T1 - DEVELOPMENTAL PSYCHOLOGY.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1963/02//
VL - 14
IS - 1
M3 - Article
SP - 1
EP - 28
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 32898265; Rheingold, Harriet L. 1 Stanley, Walter C. 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Source Info: 1963, Vol. 14 Issue 1, p1; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, T.N.
AU - Dray, Sheldon
AU - Ellsworth, Barbara
AU - Harris, Susanna
T1 - Rabbit Gamma-Globulin Allotypes as Genetic Markers for the Source of Antibody Produced in Recipients of Shigella-Incubated Lymph Node Cells.
JO - Immunology
JF - Immunology
Y1 - 1963/03//
VL - 6
IS - 2
M3 - Article
SP - 169
EP - 178
PB - Wiley-Blackwell
SN - 00192805
AB - Rabbits homozygous for each of an allelic pair of allotypes of γ globulin (A4 and A5) were used as donors and recipients of transferred antigen-incubated lymph node cells, the cells of donors of one allotype being in each case transferred to recipients of the other. When agglutinins to Shigella (the source of the antigen with which the lymph node dells were incubated) appeared in the sera of the recipient animals, the allotype of the agglutinin was determined by adsorbing it to Shigella on a glass slide, then treating the preparations with fluorescein-conjugated rabbit anti-A5-γ-globulin and anti-A4-γ-globulin antisera, respectively. In each case the reactions of the recipients' sera were positive for γ globulin of the donors' allotype but not of their own. Positive reactions were given only by sera above a certain range of agglutinin titre. After sufficient decline of the agglutinin level in the sera of the recipients, these animals were actively immunized with Shigella. The agglutinins that now appeared in these rabbits gave positive reactions with the fluorescent antibody against their own allotype. These data indicated that in moderately X-irradiated rabbits given antigen-incubated rabbit lymph node cells, the antibody that subsequently appears in the recipient's serum has been synthesized by the donor's cells. These experiments also illustrate the use of allotypes as genetic markers in lymph node cell transfer experiments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAMMA globulins
KW - GENETIC markers
KW - LYMPH nodes
KW - IMMUNOGLOBULIN allotypes
KW - IMMUNOGENETICS
KW - IMMUNOLOGY
N1 - Accession Number: 12673789; Harris, T.N. 1 Dray, Sheldon 1 Ellsworth, Barbara 1 Harris, Susanna 1; Affiliation: 1: Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), Laboratory of Immunology, National Institute of Allergy and Infectious Diseases; Source Info: Mar63, Vol. 6 Issue 2, p169; Subject Term: GAMMA globulins; Subject Term: GENETIC markers; Subject Term: LYMPH nodes; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGENETICS; Subject Term: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haertzen, Charles A.
AU - Hill, Harris E.
T1 - ASSESSING SUBJECTIVE EFFECTS OF DRUGS: AN INDEX OF CARELESSNESS AND CONFUSION FOR USE WITH THE ADDICTION RESEARCH CENTER INVENTORY (ARCI).
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1963/10//
VL - 19
IS - 4
M3 - Article
SP - 407
EP - 412
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article presents information on a study conducted to determine the subjective effects of drugs. The data presented in the study were collected from the Addiction Research Center Inventory. A need to establish some reliability became necessary because the inventory could be used several times by the same subjects. The data was used to evaluate illiteracy, carelessness and drug-induced confusion while administering drugs to patients.
KW - DRUGS -- Effectiveness
KW - RESEARCH institutes
KW - DRUGS -- Physiological effect
KW - TESTING
KW - LITERACY
KW - PATIENTS
KW - ADDICTION Research Center (U.S.)
N1 - Accession Number: 16763512; Haertzen, Charles A. 1 Hill, Harris E. 1; Affiliation: 1: National Institute of Mental Health, Addiction Research Center PHS Hospital, Lexington, Kentucky.; Source Info: Oct1963, Vol. 19 Issue 4, p407; Subject Term: DRUGS -- Effectiveness; Subject Term: RESEARCH institutes; Subject Term: DRUGS -- Physiological effect; Subject Term: TESTING; Subject Term: LITERACY; Subject Term: PATIENTS; Company/Entity: ADDICTION Research Center (U.S.); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Erlich, Howard J.
T1 - These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations.
JO - Sociological Quarterly
JF - Sociological Quarterly
Y1 - 1964///Spring64
VL - 5
IS - 2
M3 - Book Review
SP - 177
EP - 178
SN - 00380253
AB - Reviews the book "These Rights They Seek: A Comparison of the Goals and Techniques of Local Civil Rights Organizations," by Jacqueline J. Clarke.
KW - CIVIL rights organizations
KW - NONFICTION
KW - CLARKE, Jacqueline J.
KW - THESE Rights They Seek (Book)
N1 - Accession Number: 14021169; Erlich, Howard J. 1; Affiliation: 1: National Institute of Mental Health; Source Info: Spring64, Vol. 5 Issue 2, p177; Subject Term: CIVIL rights organizations; Subject Term: NONFICTION; Reviews & Products: THESE Rights They Seek (Book); NAICS/Industry Codes: 813310 Social advocacy organizations; NAICS/Industry Codes: 813311 Human Rights Organizations; People: CLARKE, Jacqueline J.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simmons, William L.
AU - Tyler, Forrest B.
T1 - A COMPARISON OF PATIENT AND STAFF CONCEPTIONS OF THERAPISTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1964/10//
VL - 20
IS - 4
M3 - Article
SP - 508
EP - 512
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article measures staff perceptions, however, the emphasis professional disciplines can predict perceptions and compares them with patient is on determining whether members of various how they are seen by patients. The subjects consisted of 19 volunteers from the professional staff working on a ward on which patient data were gathered at the Anna State Hospital, Anna, Illinois, between December, 1961, and August, 1962. The comparison of staff and patient usage of each category for each discipline reveals some very striking differences. It appears that staff personnel conceptualize therapeutic disciplines primarily in terms of the nature of their skills, duties, or professional identification, or of some evaluation of these task related activities.
KW - PHYSICIAN & patient
KW - INTERPERSONAL relations
KW - MEDICAL personnel & patient
KW - VOLUNTEER service
KW - PUBLIC hospitals
KW - ILLINOIS
N1 - Accession Number: 15844215; Simmons, William L. 1 Tyler, Forrest B. 2; Affiliation: 1: University of Arizona 2: National Institute of Mental Health; Source Info: Oct1964, Vol. 20 Issue 4, p508; Subject Term: PHYSICIAN & patient; Subject Term: INTERPERSONAL relations; Subject Term: MEDICAL personnel & patient; Subject Term: VOLUNTEER service; Subject Term: PUBLIC hospitals; Subject Term: ILLINOIS; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alderman, Michael H.
T1 - Why We Need Medicare.
JO - New Republic
JF - New Republic
Y1 - 1964/12/26/
VL - 151
IS - 26
M3 - Article
SP - 17
EP - 20
SN - 00286583
AB - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964. Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare.
KW - MEDICAL care -- United States
KW - MEDICAL care for the aged
KW - SOCIAL security -- Law & legislation
KW - MEDICARE
KW - HEALTH insurance -- United States
KW - UNITED States
N1 - Accession Number: 10013939; Alderman, Michael H. 1; Affiliation: 1: US Public Health Service, National Institutes of Health, Bethesda, Maryland; Source Info: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Surwillo, Walter W.
AU - Quilter, Reginald E.
T1 - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1965/01//
VL - 1
IS - 3
M3 - Article
SP - 272
EP - 276
SN - 00485772
AB - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GALVANIC skin response
KW - VIGILANCE (Psychology)
KW - SIGNAL detection (Psychology)
KW - CONDITIONED response
KW - MALES
KW - BEHAVIORISM (Psychology)
KW - AGE
KW - Aging.
KW - Autonomic
KW - Skin Potential
KW - Spontaneous SPR
KW - Tarchanoff effect
KW - Vigilance
KW - Watchkeeping
N1 - Accession Number: 11044659; Surwillo, Walter W. 1 Quilter, Reginald E. 1; Affiliation: 1: National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; Source Info: Jan1965, Vol. 1 Issue 3, p272; Subject Term: GALVANIC skin response; Subject Term: VIGILANCE (Psychology); Subject Term: SIGNAL detection (Psychology); Subject Term: CONDITIONED response; Subject Term: MALES; Subject Term: BEHAVIORISM (Psychology); Subject Term: AGE; Author-Supplied Keyword: Aging.; Author-Supplied Keyword: Autonomic; Author-Supplied Keyword: Skin Potential; Author-Supplied Keyword: Spontaneous SPR; Author-Supplied Keyword: Tarchanoff effect; Author-Supplied Keyword: Vigilance; Author-Supplied Keyword: Watchkeeping; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Richard Q.
T1 - DEVELOPMENTAL PSYCHOLOGY.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1965/02//
VL - 16
IS - 1
M3 - Article
SP - 1
EP - 38
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11301340; Bell, Richard Q. 1; Affiliation: 1: Child Research Branch, National Institute of Mental Health; Source Info: 1965, Vol. 16 Issue 1, p1; Number of Pages: 38p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schaefer, Earl S.
T1 - DOES THE SAMPLING METHOD PRODUCE THE NEGATIVE CORRELATION OF MEAN IQ WITH AGE REPORTED BY KENNEDY, VAN DE RIET, AND WHITE?
JO - Child Development
JF - Child Development
Y1 - 1965/03//
VL - 36
IS - 1
M3 - Article
SP - 257
EP - 259
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12083521; Schaefer, Earl S. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Mar1965, Vol. 36 Issue 1, p257; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Surwillo, Walter W.
AU - Arenberg, David L.
T1 - ON THE LAW OF INITIAL VALUE AND THE MEASUREMENT OF CHANGE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1965/04//
VL - 1
IS - 4
M3 - Article
SP - 368
EP - 370
SN - 00485772
AB - The article demonstrates the variable change measurements and the application of law of initial value (LIV) test in the study of autonomic variables in every individual within the experimental groups. The measurements on the changes without an intervening stimulus was presented using the criterion on pre-stimulus and post-stimulus values of variables by D. J. Hord, L. C. Johnson and A. Lubin. The LIV was demonstrated by using the heart rate data collected from the group when doing a simple reaction task.
KW - HEART beat
KW - INITIAL value problems
KW - NUMERICAL analysis
KW - CARDIAC contraction
KW - CRITERION referenced tests
N1 - Accession Number: 19001963; Surwillo, Walter W. 1 Arenberg, David L. 1; Affiliation: 1: National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Source Info: Apr1965, Vol. 1 Issue 4, p368; Subject Term: HEART beat; Subject Term: INITIAL value problems; Subject Term: NUMERICAL analysis; Subject Term: CARDIAC contraction; Subject Term: CRITERION referenced tests; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bayley, Nancy
T1 - COMPARISONS OF MENTAL AND MOTOR TEST SCORES FOR AGES 1-15 MONTHS BY SEX, BIRTH ORDER, RACE, GEOGRAPHICAL LOCATION, AND EDUCATION OF PARENTS.
JO - Child Development
JF - Child Development
Y1 - 1965/06//
VL - 36
IS - 2
M3 - Article
SP - 379
EP - 411
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12084360; Bayley, Nancy 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1965, Vol. 36 Issue 2, p379; Number of Pages: 33p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schaefer, Earl S.
T1 - CHILDREN'S REPORTS OF PARENTAL BEHAVIOR: AN INVENTORY.
JO - Child Development
JF - Child Development
Y1 - 1965/06//
VL - 36
IS - 2
M3 - Article
SP - 413
EP - 424
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12084370; Schaefer, Earl S. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1965, Vol. 36 Issue 2, p413; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boomer, Donald S.
T1 - HESITATION AND GRAMMATICAL ENCODING.
JO - Language & Speech
JF - Language & Speech
Y1 - 1965/07//Jul-Sep65
VL - 8
IS - 3
M3 - Article
SP - 148
EP - 158
PB - Sage Publications, Ltd.
SN - 00238309
AB - The article focuses on a study that concerns in the occurrence of filled and unfilled pauses of hesitations with respect to their location in phonemic clauses in spontaneous English speech. Both types of hesitation were most frequent after the first word in the clause, regardless of length. In this study, the data to be presented concern the location of these hesitations in extended utterances, but the basic theoretical issue involved is the nature of the grammatical encoding process in speech. These data are regarded as directly challenging the transitional probability theory of hesitations. In addition, the phonemic clause is proposed as the encoding unit of speech at the grammatical level.
KW - SPEECH -- Study & teaching
KW - LANGUAGE & languages -- Study & teaching
KW - ENGLISH language -- Study & teaching
KW - HESITATION form (Linguistics)
KW - CLAUSES (Grammar)
KW - JUNCTURE (Linguistics)
KW - LINGUISTICS
KW - PHONETICS
KW - PHONOLOGICAL encoding
N1 - Accession Number: 21832518; Boomer, Donald S. 1,2; Affiliation: 1: National Institute of Mental Health, Bethesda 2: Laboratory of Psychology, National Institute of Mental Health, National Institutes of Health, Department of Health, Education and Welfare; Source Info: Jul-Sep65, Vol. 8 Issue 3, p148; Subject Term: SPEECH -- Study & teaching; Subject Term: LANGUAGE & languages -- Study & teaching; Subject Term: ENGLISH language -- Study & teaching; Subject Term: HESITATION form (Linguistics); Subject Term: CLAUSES (Grammar); Subject Term: JUNCTURE (Linguistics); Subject Term: LINGUISTICS; Subject Term: PHONETICS; Subject Term: PHONOLOGICAL encoding; NAICS/Industry Codes: 611630 Language Schools; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Asheron, G. L.
AU - Stone, S. H.
T1 - Selective and Specific Inhibition of 24 Hour Skin Reactions in the Guinea-Pig I. IMMUNE DEVIATION: DESCRIPTION OF THE PHENOMENON AND THE EFFECT OF SPENECTOMY.
JO - Immunology
JF - Immunology
Y1 - 1965/09//
VL - 9
IS - 3
M3 - Article
SP - 205
EP - 217
PB - Wiley-Blackwell
SN - 00192805
AB - Strong 24 hour skin reactions occur in guinea-pigs immunized with antigen in Freund's complete adjuvant. These reactions were reduced by the injection of 1 mg of the same antigen, in either the soluble or alum precipitated form, 14 days before immunization with antigen in Freund's complete adjuvant. There was also a reduction in the corneal reaction, which has been regarded as an index of delayed hypersensitivity. This phenomenon was called immune deviation. The phenomenon was demonstrated for bovine γ-globulin, human serum albumin, bovine serum albumin, egg albumin, diptheria toxoid, hacmocyanin, purified protein derivative (PPD) and dinitrophenylated proteins. Ten mg of soluble bovine γ-globulin caused considerable reduction of the circulating antibody level and of the 24 hour skin reaction. Alum precipitated bovine γ-globulin and smaller doses of soluble antigen reduced the skin reaction but had less effect on the antibody level. Similar results were obtained with human serum albumin. This suggested that the conditions for eliciting immune paralysis and immune deviation were different. Immune deviation was obtained with either footpad or intravenous injections and with as little as 100 µg of antigen. Alum precipitated bovine γ-globulin caused immune deviation when given 14, 7 or 1 day before or 1 day after immunization with antigen in Freund's complete adjuvant. It was inactive when given 6 days after immunization. Splenectomy had no effect on the production or deviation of 24 hour skin reactions. Alum precipitated antigen had a variable and usually slight effect on the level of antibody following immunization with the same antigen in Freund's complete adjuvant. There was, however, a qualitative alteration in the antibody. The sera of guinea-pigs, which had been deviated by a prior injection of bovine serum albumin or bovine γ-globulin, showed only a gamma;1 line of antibody on immunoelectrophoresis, while the sera of control guinea-pigs also showed the γ2 line characteristically seen in guinea-pigs immunized with antigen in Freund's complete adjuvant. It was concluded that immune deviation was distinct from classical immune paralysis and that the immunologically specific reduction of the 24 hour skin reactions might be due, at least in part, to a selective loss of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - ANTIGENS
KW - DELAYED hypersensitivity
KW - GLOBULINS
KW - ALBUMINS
KW - PROTEINS
KW - IMMUNOGLOBULINS
KW - ALUM
KW - SPLENECTOMY
KW - ANIMAL models in research
N1 - Accession Number: 13279305; Asheron, G. L. 1 Stone, S. H. 2; Affiliation: 1: National Institute for Medical Research, Mill Hill, London, England 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: Sep65, Vol. 9 Issue 3, p205; Subject Term: IMMUNIZATION; Subject Term: ANTIGENS; Subject Term: DELAYED hypersensitivity; Subject Term: GLOBULINS; Subject Term: ALBUMINS; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULINS; Subject Term: ALUM; Subject Term: SPLENECTOMY; Subject Term: ANIMAL models in research; NAICS/Industry Codes: 212391 Potash, Soda, and Borate Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berger, Ralph J.
AU - Meier, Gilbert W.
T1 - AN AUTOMATIC ANALYZER OF STATES OF VIGILANCE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1965/10//
VL - 2
IS - 2
M3 - Article
SP - 141
EP - 145
SN - 00485772
AB - An assemblage of relay-operated, commercially available programming modules is described. It is capable of discriminating among the states of vigilance - wakefulness (W); high-voltage, slow-wave sleep (HVS); and low-voltage, fast-wave sleep (LVF) - and it requires information from only the nuchal electromyogram (EMG) and the electrooculogram (EOG). [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAL analyzers
KW - SLEEP
KW - VIGILANCE (Psychology)
KW - CENTRAL nervous system
KW - SLEEP-wake cycle
KW - DREAMS
KW - Analyzer
KW - Dreaming.
KW - Sleep
KW - Vigilance
N1 - Accession Number: 11046049; Berger, Ralph J. 1 Meier, Gilbert W. 1; Affiliation: 1: Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; Source Info: Oct1965, Vol. 2 Issue 2, p141; Subject Term: NEURAL analyzers; Subject Term: SLEEP; Subject Term: VIGILANCE (Psychology); Subject Term: CENTRAL nervous system; Subject Term: SLEEP-wake cycle; Subject Term: DREAMS; Author-Supplied Keyword: Analyzer; Author-Supplied Keyword: Dreaming.; Author-Supplied Keyword: Sleep; Author-Supplied Keyword: Vigilance; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Bower, Eli M.
T1 - The Return of Rumpelstiltskin: Reaction to Mesinger's Article.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1965/12//
VL - 32
IS - 4
M3 - Letter
SP - 238
EP - 239
SN - 00144029
AB - A letter to the editor is presented in response to the article "Emotionally Disturbed and Brain Damaged Children: Should We Mix Them?" published within the issue.
KW - LETTERS to the editor
KW - EXCEPTIONAL children
N1 - Accession Number: 19692833; Bower, Eli M. 1; Affiliation: 1: Consultant, Mental Health in Education, Research Utilization Branch, National Institute of Mental Health, Bethesda, Maryland; Source Info: Dec1965, Vol. 32 Issue 4, p238; Subject Term: LETTERS to the editor; Subject Term: EXCEPTIONAL children; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dittmann, Allen T.
T1 - PSYCHOTHERAPEUTIC PROCESSES.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1966/02//
VL - 17
IS - 1
M3 - Article
SP - 51
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11298999; Dittmann, Allen T. 1; Affiliation: 1: National Institute of Mental Health in Bethesda, Maryland; Source Info: 1966, Vol. 17 Issue 1, p51; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zolik, Edwin S.
AU - Marcres, Joseph B.
T1 - AN APPARENT "ZONE OF INVISIBILITY" IN COMMUNITY MENTAL HEALTH PROGRAMS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1966/04//
VL - 22
IS - 2
M3 - Article
SP - 239
EP - 245
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study in which the percentage distribution by age group of cases reported as having a functional non-psychotic disorder for two patient samples is presented. To determine whether the low prevalence evidenced in the 18-24 year group was affected by the absence from Northern Virginia of individuals obtaining post high school education an analysis was done of the institutions attended by 1607 high school graduates. Results suggest the existence of a "zone of invisibility" in community mental health practice with regard to individuals in the 18-24 age range. Socio-cultural factors appear to be the major variables contributing to this apparent invisibility. Methods for increasing visibility or contact with these persons and other implications are discussed.
KW - MENTAL health
KW - AGE groups
KW - PSYCHOSES
KW - PATIENTS
KW - SCHOOLS
KW - SOCIOCULTURAL factors
N1 - Accession Number: 15844451; Zolik, Edwin S. 1 Marcres, Joseph B. 2; Affiliation: 1: De Paul University Chicago, Illinois 2: National Institute of Mental Health Bethesda, Maryland.; Source Info: Apr1966, Vol. 22 Issue 2, p239; Subject Term: MENTAL health; Subject Term: AGE groups; Subject Term: PSYCHOSES; Subject Term: PATIENTS; Subject Term: SCHOOLS; Subject Term: SOCIOCULTURAL factors; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, B. E.
AU - Ayres, J. J. B.
T1 - SIGNIFICANCE AND RELIABILITY OF SHOCK-IN-DUCED CHANGES IN BASAL SKIN CONDUCTANCE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1966/04//
VL - 2
IS - 4
M3 - Article
SP - 322
EP - 326
SN - 00485772
AB - Once weekly for 5 weeks, 15 adult male postaddicts were given 12 to 15 shocks of 5.0 to 8.0 ma. Basal skin conductance (BSC) was recorded during the 25-rain weekly sessions. Increases in BSC during each session and the week-to-week reliabilities of the increases were determined. After the first week, subsequent increases showed reliability coefficients which ranged from 0.69 to 0.95 (P < 0.01). The reliabilities of the increases in BSC produced by shock were considered favorable for the use of change in BSC as a dependent variable in designs requiring repeated measurements on the same Ss at weekly intervals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GALVANIC skin response
KW - REFLEXES
KW - SKIN -- Physiology
KW - RELIABILITY (Personality trait)
KW - Basal Skin Conductance. (B. E. Jones)
KW - Methodology
N1 - Accession Number: 11047181; Jones, B. E. 1 Ayres, J. J. B. 1; Affiliation: 1: National Institute of Mental Health Addiction Research Center, Lexington, Kentucky.; Source Info: Apr1966, Vol. 2 Issue 4, p322; Subject Term: GALVANIC skin response; Subject Term: REFLEXES; Subject Term: SKIN -- Physiology; Subject Term: RELIABILITY (Personality trait); Author-Supplied Keyword: Basal Skin Conductance. (B. E. Jones); Author-Supplied Keyword: Methodology; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berger, Ralph J.
AU - Meier, Gilbert W.
T1 - THE EFFECTS OF SELECTIVE DEPRIVATION OF STATES OF SLEEP IN THE DEVELOPING MONKEY.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1966/04//
VL - 2
IS - 4
M3 - Article
SP - 354
EP - 371
SN - 00485772
AB - Four groups, two comprising three neonatal rhesus monkeys and two comprising two juvenile rhesus monkeys, were selectively deprived of either low-voltage, fastwave sleep (LVF) or of high.voltage, slow-wave sleep (HVS), respectively. Both infant and juvenile Ss displayed an over-all increase in threshold to the tone-shock combination during the deprivation of either phase of sleep. However, the thresholds of the infant Ss were greater, throughout deprivation, than the thresholds of the juvenile Ss. The juvenile Ss exposed to LVF deprivation were unique in exhibiting a sharp increase in frequency of forced awakenings from LVF, to values significantly greater than for the other groups, and in displaying compensatory recovery effects, manifested by increases in proportion of total sleep time spent in LVF, following termination of deprivation. Behavioral disturbances accompanying deprivation were not evident in any of the experimental groups. The study revealed a number of methodological problems related to the definition and to the selective deprivation of a particular state of sleep. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SLEEP deprivation
KW - AROUSAL (Physiology)
KW - PSYCHOPHYSIOLOGY
KW - ONTOGENY
KW - Arousal
KW - Dream deprivation
KW - Ontogeny. (R. J. Berger)
KW - Sleep deprivation
N1 - Accession Number: 11047250; Berger, Ralph J. 1 Meier, Gilbert W. 1; Affiliation: 1: Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, San Juan, Puerto Rico.; Source Info: Apr1966, Vol. 2 Issue 4, p354; Subject Term: SLEEP deprivation; Subject Term: AROUSAL (Physiology); Subject Term: PSYCHOPHYSIOLOGY; Subject Term: ONTOGENY; Author-Supplied Keyword: Arousal; Author-Supplied Keyword: Dream deprivation; Author-Supplied Keyword: Ontogeny. (R. J. Berger); Author-Supplied Keyword: Sleep deprivation; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, J.
AU - Frei, J. V.
AU - Cohen, J. J.
AU - Rose, B.
AU - Richter, M.
T1 - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions.
JO - Immunology
JF - Immunology
Y1 - 1966/08//
VL - 11
IS - 2
M3 - Article
SP - 155
EP - 162
PB - Wiley-Blackwell
SN - 00192805
AB - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BASAL lamina
KW - IMMUNE serums
KW - TISSUES
KW - SODIUM hydroxide
KW - IMMUNOGLOBULINS
KW - RABBITS as laboratory animals
KW - ANTIGENS
N1 - Accession Number: 13284172; Myers, J. 1 Frei, J. V. 2 Cohen, J. J. 3,4 Rose, B. 3,4 Richter, M. 5; Affiliation: 1: United States Public Health Service Special Research Fellow. 2: Research Associate, National Cancer Institute of Canada. 3: Division of Immunochemistry and Allergy, Royal Victoria, Hospital, Canada. 4: Department of Pathology, McGill University, Montreal, Quebec, Canada. 5: Medical Research Associate, Medical Research Council, Canada.; Source Info: Aug66, Vol. 11 Issue 2, p155; Subject Term: BASAL lamina; Subject Term: IMMUNE serums; Subject Term: TISSUES; Subject Term: SODIUM hydroxide; Subject Term: IMMUNOGLOBULINS; Subject Term: RABBITS as laboratory animals; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325181 Alkali and chlorine manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mergenhagen, S. E.
AU - Notkins, A. L.
AU - Evans, R. T.
T1 - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies.
JO - Immunology
JF - Immunology
Y1 - 1966/09//
VL - 11
IS - 3
M3 - Article
SP - 223
EP - 228
PB - Wiley-Blackwell
SN - 00192805
AB - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies.
KW - GAMMA globulins
KW - IMMUNOGLOBULINS
KW - AGGLUTINATION of blood
KW - IMMUNE serums
KW - ERYTHROCYTES
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 14578238; Mergenhagen, S. E. Notkins, A. L. 1 Evans, R. T. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, .National Institute of Dental Research, Bethesda, Maryland 20014; Source Info: Sep66, Vol. 11 Issue 3, p223; Subject Term: GAMMA globulins; Subject Term: IMMUNOGLOBULINS; Subject Term: AGGLUTINATION of blood; Subject Term: IMMUNE serums; Subject Term: ERYTHROCYTES; Subject Term: ANTIGEN-antibody reactions; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gorsuch, Richard L.
AU - Spielberger, Charles D.
T1 - Anxiety, threat, and awareness in verbal conditioning.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1966/09//
VL - 34
IS - 3
M3 - Article
SP - 336
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8933677; Gorsuch, Richard L. 1 Spielberger, Charles D. 2; Affiliation: 1: Vanderbilt University. 2: National Institute for Mental Health, Bethesda, Maryland.; Source Info: Sep66, Vol. 34 Issue 3, p336; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1467-6494.ep8933677
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raskin, Allen
AU - Schulterbrandt, Joy G.
AU - Reatig, Natalie
T1 - RATER AND PATIENT CHARACTERISTICS ASSOCIATED WITH RATER DIFFERENCES IN PSYCHIATRIC SCALE RATINGS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1966/10//
VL - 22
IS - 4
M3 - Article
SP - 417
EP - 423
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents information on psychiatric scales rating. The Inpatient Multidimensional Psychiatric Scale (IMPS) is designed for use by psychiatrists and psychologists following a 30 to 60 minute interview with the patient. Although the reported reliabilities of the 10 IMPS factor scores derived from this scale are high the background of the rater plays some part in rating the presence and magnitude of specified forms of psychopathology.
KW - MENTAL health personnel
KW - NEUROLOGISTS
KW - PSYCHIATRISTS
KW - BEHAVIOR
KW - PATHOLOGICAL psychology
KW - PUBLIC health
N1 - Accession Number: 15980569; Raskin, Allen 1 Schulterbrandt, Joy G. 1 Reatig, Natalie 1; Affiliation: 1: National Institute of Mental Health, Bethesda, Maryland; Source Info: Oct1966, Vol. 22 Issue 4, p417; Subject Term: MENTAL health personnel; Subject Term: NEUROLOGISTS; Subject Term: PSYCHIATRISTS; Subject Term: BEHAVIOR; Subject Term: PATHOLOGICAL psychology; Subject Term: PUBLIC health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oppenheim, J. J.
AU - Wolstencroft, R. A.
AU - Gell, P. G. H.
T1 - Delayed Hypersensitivity in the Guinea-Pig to a Protein-Hapten Conjugate and its Relationship to in vitro Transformation of Lymph Node, Spleen, Thymus and Peripheral Blood Lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1967/01//
VL - 12
IS - 1
M3 - Article
SP - 89
EP - 102
PB - Wiley-Blackwell
SN - 00192805
AB - Guinea-pig delayed hypersensitivity to purified protein derivative (PPD) and guinea-pig albumin-orthanilic acid (AO) was produced in the absence of detectable antibody formation to the conjugate. Ten days after sensitization the guinea-pig peripheral leucocytes, lymph nodes, spleen and thymus cell suspensions were cultured from 1 to 5 days with various concentrations of immunizing antigens, unconjugated hapten, a hapten—ovalbumin conjugate or phytohaemagglutinin (PHA). All the cultures of ‘draining’ lymph node cells, and about 40 per cent of the spleen and peripheral leucocyte cultures manifested increased lymphocyte transformation on radioautographs, and by total tritiated thymidine incorporation when stimulated by PPD or AO. In addition all the cultures responded well to PHA. However, lymphocytes from the mediastinal and cervical lymph nodes from the immunized, and most of the lymphoid organ cultures from unimmunized guinea-pigs were not stimulated by antigens but responded only to PHA. Cultured guinea-pig thymocytes did not respond to any stimulus. The in vitro lymphocyte proliferation was carrier specific. It did not occur in response to unconjugated hapten. However, the response to AO was partially inhibited in the presence of the hapten. The in vitro kinetics and morphological changes in the cultures also were investigated, and the immunological significance and specificity of lymphocyte transformation are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINS
KW - PROTEINS
KW - LEUCOCYTES
KW - KILLER cells
KW - BLOOD cells
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGY
N1 - Accession Number: 13320964; Oppenheim, J. J. 1 Wolstencroft, R. A. 2 Gell, P. G. H. 2; Affiliation: 1: NIDR, National Institutes of Health, Bethesda, U.S.A. 2: Department of Experimental Pathology, University of Birmingham; Source Info: Jan67, Vol. 12 Issue 1, p89; Subject Term: ALBUMINS; Subject Term: PROTEINS; Subject Term: LEUCOCYTES; Subject Term: KILLER cells; Subject Term: BLOOD cells; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weiss, George H.
T1 - The Theory of Road Traffic Flow (Book).
JO - Transportation Science
JF - Transportation Science
Y1 - 1967/02//
VL - 1
IS - 1
M3 - Book Review
SP - 47
PB - INFORMS: Institute for Operations Research
SN - 00411655
AB - Reviews the book "The Theory of Road Traffic Flow," by Winifred D. Ashton.
KW - TRAFFIC flow
KW - NONFICTION
KW - ASHTON, Winifred
KW - ASHTON, Winifred D.
KW - THEORY of Road Traffic Flow, The (Book)
N1 - Accession Number: 4471158; Weiss, George H. 1; Affiliation: 1: National Institutes of Health, Bethesda, Maryland.; Source Info: Feb67, Vol. 1 Issue 1, p47; Subject Term: TRAFFIC flow; Subject Term: NONFICTION; Reviews & Products: THEORY of Road Traffic Flow, The (Book); People: ASHTON, Winifred; People: ASHTON, Winifred D.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scott, Phyllis M.
AU - Burton, Roger V.
AU - Yarrow, Marian Radke
T1 - SOCIAL REINFORCEMENT UNDER NATURAL CONDITIONS.
JO - Child Development
JF - Child Development
Y1 - 1967/03//
VL - 38
IS - 1
M3 - Article
SP - 53
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 10429504; Scott, Phyllis M. 1 Burton, Roger V. 1 Yarrow, Marian Radke 1; Affiliation: 1: National Institute of Mental Health; Source Info: Mar1967, Vol. 38 Issue 1, p53; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, William T.
AU - Claus, George
T1 - ULTRASTRUCTURAL STUDIES ON THE CYANELLES OF CLAUCOCYSTIS NOSTOCHINEARUM ITZIGSOHN.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1967/03//
VL - 3
IS - 1
M3 - Article
SP - 37
EP - 51
SN - 00223646
AB - Ultrastructural studies conducted on the intracellular symbiont of Glaucocystis nostochinearum Itz., a unicellular alga with a debated taxonomic position have shown that the endosymbiont, although somewhat aberrant, is a blue-green alga. Due possibly to its intracellular habitat, it lacks the characteristic cyanophycean double-layered cell wall and the cells appear to be completely naked, bound only by a single plasma membrane. The protoplasm of the cell is differentiated into the lamellated chromatoplasm, which contains the photosynthetic pigments and poly-phosphate granules, and a nonlamellar centroplasm, in winch the nucleic material is dispersed. The usual cyanophycean organelles, as well as the different vacuoles and granules, with the exception of the formed bodies, are missing. Approximately 10% of the cells shows a peculiar homogeneous area at one tip, nature of which is unknown. Binary fission the organism is mentioned. Since this cyanelle not yet been classified, we name it Skujapelta nuda nov. gen., nov. sp.; and because of its structural peculiarities we find it necessary to create a new family for it, Skujapeltaceae in the order Chroococcales. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - HABITAT (Ecology)
KW - CELL membranes
KW - BIOLOGICAL pigments
KW - PAINT materials
KW - ART materials
N1 - Accession Number: 11578700; Hall, William T. 1 Claus, George 2; Affiliation: 1: National Cancer Institute, Bethesda, Maryland 20014. 2: Graduate Department of Marine Science, Long Island University, Brookville; Source Info: Mar1967, Vol. 3 Issue 1, p37; Subject Term: CELLS; Subject Term: HABITAT (Ecology); Subject Term: CELL membranes; Subject Term: BIOLOGICAL pigments; Subject Term: PAINT materials; Subject Term: ART materials; NAICS/Industry Codes: 339940 Office Supplies (except Paper) Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ben-Efraim, S.
AU - Fuchs, Sara
AU - Sela, M.
T1 - Differences in Immune Response to Synthetic Antigens in Two Inbred Strains of Guinea-Pigs.
JO - Immunology
JF - Immunology
Y1 - 1967/05//
VL - 12
IS - 5
M3 - Article
SP - 573
EP - 581
PB - Wiley-Blackwell
SN - 00192805
AB - The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into three categories: (a) immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; (b) irnmunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and (c) immunogenic in strain 2 and negative in strain 13 : linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F1 hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.
KW - PEPTIDES
KW - TYROSINE
KW - GLUTAMIC acid
KW - ALANINE
KW - LYSINE
KW - COPOLYMERS
KW - OPTICAL isomers
KW - GUINEA pigs as laboratory animals
N1 - Accession Number: 13331987; Ben-Efraim, S. 1,2 Fuchs, Sara 1,2 Sela, M. 1,2; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 2: Section of Chemical Immunology, The Weizmann Institute of Science, Rehovoth, Israel; Source Info: May67, Vol. 12 Issue 5, p573; Subject Term: PEPTIDES; Subject Term: TYROSINE; Subject Term: GLUTAMIC acid; Subject Term: ALANINE; Subject Term: LYSINE; Subject Term: COPOLYMERS; Subject Term: OPTICAL isomers; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Asherson, G. L.
AU - Stone, S. H.
T1 - Desensitization in vitro-The Specific Inhibition, by Antigen, of the Passive Transfer of Delayed Hypersensitivity by Peritoneal Exudate Cells.
JO - Immunology
JF - Immunology
Y1 - 1967/11//
VL - 13
IS - 5
M3 - Article
SP - 469
EP - 475
PB - Wiley-Blackwell
SN - 00192805
AB - A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the 24-hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD. The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed hypersensitivity to PPD. Likewise, it was possible to diminish the passive transfer of delayed hypersensitivity to bovine γ-globulin by peritoneal exudate cells, by exposure of the ceils to bovine γ-globulin in vitro. The recipients were tested immediately after cell transfer. This in vitro desensitization was specific, in that the transfer of delayed hypersensitivity to PPD was unaffected. Exposure of cells in vitro to hypotonic conditions and antibody to guinea-pig γ-globulin did not prevent the passive transfer of delayed hypersensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY desensitization
KW - ALLERGY
KW - GLOBULINS
KW - ANTIGENS
KW - ANIMAL models in research
KW - IMMUNOLOGY
N1 - Accession Number: 13342845; Asherson, G. L. 1 Stone, S. H. 2; Affiliation: 1: Department of Bacteriology, London Hospital Medical College, London, England 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA; Source Info: Nov67, Vol. 13 Issue 5, p469; Subject Term: ALLERGY desensitization; Subject Term: ALLERGY; Subject Term: GLOBULINS; Subject Term: ANTIGENS; Subject Term: ANIMAL models in research; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Drews, J.
AU - Brawerman, G.
AU - Morris, H. P.
T1 - Nucleotide Sequence Homologies in Nuclear and Cytoplasmic Ribonucleic Acid from Rat Liver and Hepatomas.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/01//
VL - 3
IS - 3
M3 - Article
SP - 284
EP - 292
PB - Wiley-Blackwell
SN - 00142956
AB - The RNA populations of rat liver and three rat hepatomas were compared by DNA-RNA hybridization studies in the presence and absence of competing RNA. The hepatoma nuclei were found to lack hybridizable RNA species present in normal liver nuclei, while the latter appeared to contain all the hepatoma RNA species. In normal liver, the cytoplasmic RNA could compete with nuclear RNA only to the extent of 20–30%. This indicates that a large number of nuclear RNA species are not transferred to the cytoplasm. In the case of the hepatomas nearly all the nuclear RNA species were detected in the cytoplasmic RNA preparations. A more extensive homology between nuclear and cytoplasmic RNA was also observed in regenerating liver. It is suggested that a selective mechanism governs the transfer of RNA species from the nucleus to the cytoplasm and that this mechanism is altered in the hepatomas. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMOLOGY (Biology)
KW - NUCLEOTIDE sequence
KW - RNA
KW - LIVER tumors
KW - HEPATOMA
KW - RATS as laboratory animals
N1 - Accession Number: 12768108; Drews, J. 1,2 Brawerman, G. 2,3 Morris, H. P. 2,4; Affiliation: 1: Medizinische Universitätsklinik, Bergheimer, Germany 2: Department of Medicine and Biochemistry, Yale University School of Medicine and National Cancer Institute, Nutrition and Biochemistry Section 3: Institut de Biologie physico-chimique, Curie, Paris-5, France 4: Nutrition and Carcinogenesis Section, National Cancer Institute, Bethesda, USA; Source Info: 1968, Vol. 3 Issue 3, p284; Subject Term: HOMOLOGY (Biology); Subject Term: NUCLEOTIDE sequence; Subject Term: RNA; Subject Term: LIVER tumors; Subject Term: HEPATOMA; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haertzen, C. A.
AU - Hooks, N. T.
AU - Monroe, J. J.
AU - Fuller, Gerald B.
AU - Sharp, Heber
T1 - NONSIGNIFICANCE OF MEMBERSHIP IN ALCOHOLICS ANONYMOUS IN HOSPITALIZED ALCOHOLICS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1968/01//
VL - 24
IS - 1
M3 - Article
SP - 99
EP - 103
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses nonsignificance of membership in alcoholics anonymous in hospitalized alcoholics. Members and nonmembers of AA in a hospital setting were compared on the Addiction Research Center Inventory (ARCI) and Inventory of Habits and Attitudes (lHA). Both tests measure personality and adjustment characteristics, but the former test is a sensitive measure of subjective experience associated with drugs and alcohol withdrawal, whereas the IHA test gives an indication of the history of alcohol use, functional utility of alcohol, environmental press for using alcohol, and acceptability for therapy. In studies of these tests involving over 700 Ss, AA membership was not a significant determinant of individual differences in response.
KW - ALCOHOLICS
KW - ATTITUDE (Psychology)
KW - RESEARCH institutes
KW - DRINKING of alcoholic beverages
KW - DIFFERENTIAL psychology
KW - PSYCHOLOGICAL tests
N1 - Accession Number: 15866117; Haertzen, C. A. 1 Hooks, N. T. 1 Monroe, J. J. 1 Fuller, Gerald B. 2 Sharp, Heber 3; Affiliation: 1: National Institute of Mental Health, Addiction Research Center, Lexington, Ky. 2: Central Michigan University. 3: Willmar (Minn.) State Hospital.; Source Info: Jan1968, Vol. 24 Issue 1, p99; Subject Term: ALCOHOLICS; Subject Term: ATTITUDE (Psychology); Subject Term: RESEARCH institutes; Subject Term: DRINKING of alcoholic beverages; Subject Term: DIFFERENTIAL psychology; Subject Term: PSYCHOLOGICAL tests; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zolik, Edwin S.
AU - Marches, Joseph R.
T1 - MENTAL HEALTH MORBIDITY IN A SUBURBAN COMMUNITY.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1968/01//
VL - 24
IS - 1
M3 - Article
SP - 103
EP - 108
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses mental health morbidity in a suburban community. It reports the prevalence of mental disorders in the population served by the agencies responsible for the public mental health sector of services in a rapidly growing suburban area. In the course of one week 1,516 individuals with mental or emotional disorders were reported. Analyses of the age by sex by type of disorder revealed differential morbidity rates among children and adults. Among children, males exceeded females but among adults the ratio was reversed. Married females were reported twice as frequently as married males. Psychoneurosis and personality disturbances were the two predominant disorders among adults whereas mental deficiency and personality disorders were predominant among children.
KW - MENTAL health
KW - PERSONALITY in children
KW - HUMAN sexuality
KW - FEMALES
KW - HAPPINESS
KW - PATHOLOGICAL psychology
N1 - Accession Number: 15866118; Zolik, Edwin S. 1 Marches, Joseph R. 2; Affiliation: 1: De Paul University. 2: National Institute for Mental Health Chicago, Illinois Bethesda, Maryland.; Source Info: Jan1968, Vol. 24 Issue 1, p103; Subject Term: MENTAL health; Subject Term: PERSONALITY in children; Subject Term: HUMAN sexuality; Subject Term: FEMALES; Subject Term: HAPPINESS; Subject Term: PATHOLOGICAL psychology; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lansdell, H.
AU - Polcari, A. R.
T1 - THE MEANING OF THE TAULBEE-SISSON CONFIGURATIONAL SCORE ON THE MMPI WITH NEUROSURGICAL PATIENTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1968/04//
VL - 24
IS - 2
M3 - Article
SP - 216
EP - 219
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article focuses on the meaning of the Taulbee-sission configurational score in the MMPI with neurological patients. In a previous investigation of the effect of temporal lobe removals on MMPI scores, a problem was raised with respect to the meaning of the Taulbe&Sisson (TS) configurational score with epileptic patients who had undergone neurosurgical therapy. The original purpose of the TS score is to help psychodiagnosticians decide on the basis of a pattern of scores whether a patient in a psychiatric hospital might be labeled neurotic or psychotic, but the labels do not seem adequate to describe patients with neurological impairments.
KW - TALLIES
KW - MINNESOTA Multiphasic Personality Inventory
KW - NEUROSURGERY
KW - PATIENTS
KW - EPILEPSY
KW - PSYCHODIAGNOSTICS
N1 - Accession Number: 15844756; Lansdell, H. 1 Polcari, A. R. 1; Affiliation: 1: National Institutes of Health, Bethesda, Maryland.; Source Info: Apr1968, Vol. 24 Issue 2, p216; Subject Term: TALLIES; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: NEUROSURGERY; Subject Term: PATIENTS; Subject Term: EPILEPSY; Subject Term: PSYCHODIAGNOSTICS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waldrop, Mary F.
AU - Pedersen, Frank A.
AU - Bell, Richard Q.
T1 - MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN.
JO - Child Development
JF - Child Development
Y1 - 1968/06//
VL - 39
IS - 2
M3 - Article
SP - 391
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 10398133; Waldrop, Mary F. 1 Pedersen, Frank A. 1 Bell, Richard Q. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1968, Vol. 39 Issue 2, p391; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moss, Howard A.
AU - Robson, Kenneth S.
T1 - MATERNAL INFLUENCES IN EARLY SOCIAL VISUAL BEHAVIOR.
JO - Child Development
JF - Child Development
Y1 - 1968/06//
VL - 39
IS - 2
M3 - Article
SP - 401
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 10398096; Moss, Howard A. 1 Robson, Kenneth S. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1968, Vol. 39 Issue 2, p401; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Draper, L.R.
AU - Hirata, A.A.
T1 - Antibody Responses in Rabbits to Soluble and Particulate Forms of Bovine Serum Albumin.
JO - Immunology
JF - Immunology
Y1 - 1968/07//
VL - 15
IS - 1
M3 - Article
SP - 23
EP - 30
PB - Wiley-Blackwell
SN - 00192805
AB - Antibody responses to an insoluble derivative of bovine serum albumin (IBSA) and to its corresponding soluble form (SBSA) were compared in rabbits. The two antigens could not be distinguished serologically. Less IBSA than SBSA was required to induce a detectable primary response. At higher doses, 10-20 mg/kg, IBSA evoked more prompt primary and secondary responses than SBSA but peak litres were sometimes higher in the SBSA group. After secondary injections, serum antibody litre persisted for at least 18 months in most rabbits. Early in the primary response to either form of antigen a substantial proportion of the serum antibody was of the 19S type. The shift to 7S production occurred abruptly and early after IBSA injection but it was gradual after SBSA injection, which suggested a relatively prolonged period of induction in the latter case. 75 antibody predominated during the secondary response to both antigens although the proportion of 1 9S antibody increased somewhat 4 weeks after the reinjection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - GLOBULINS
KW - ANTIGENS
KW - PLASMA cells
KW - IMMUNITY
KW - IMMUNOLOGY
N1 - Accession Number: 13346171; Draper, L.R. 1 Hirata, A.A. 1; Affiliation: 1: Laboratory of Physiology, National Cancer Institute, Bethesda, Mayland; and 20014 Department of Molecular Biology, Abbott Laboratories, North Chicago, Illinois 60064; Source Info: Jul68, Vol. 15 Issue 1, p23; Subject Term: IMMUNOGLOBULINS; Subject Term: GLOBULINS; Subject Term: ANTIGENS; Subject Term: PLASMA cells; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowen, W. J.
AU - Evans Jr., T. C.
T1 - The Binding of ATP to Myosins B and A.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/09//
VL - 5
IS - 4
M3 - Article
SP - 507
EP - 512
PB - Wiley-Blackwell
SN - 00142956
AB - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphatecreatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphate
KW - MYOSIN
KW - NUCLEOTIDES
KW - PROTEINS
KW - BIOCHEMISTRY
KW - CREATINE
N1 - Accession Number: 12791312; Bowen, W. J. 1,2 Evans Jr., T. C. 1,3; Affiliation: 1: National Institute of Arthritis and Metabolic Diseases National Institutes of Health, Public Health Service U.S. Department of Health, Education and Welfare Bethesda, Maryland 2: Bldg. 4, Room B1-06 Lab. Biophysical Chemistry National Institutes of Health, National Institute of Artritis and Metabolic Diseases, Bethesda, Maryland 20014, U.S.A. 3: Mayo Clinic, Rochester, Minnesota, 55901, U.S.A.; Source Info: 1968, Vol. 5 Issue 4, p507; Subject Term: ADENOSINE triphosphate; Subject Term: MYOSIN; Subject Term: NUCLEOTIDES; Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Subject Term: CREATINE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colten, H. R.
AU - Silverstein, A. M.
AU - Bonos, T.
AU - Rapp, H. J.
T1 - Ontogeny of the First Component of Sheep Complement.
JO - Immunology
JF - Immunology
Y1 - 1968/09//
VL - 15
IS - 3
M3 - Article
SP - 459
EP - 461
PB - Wiley-Blackwell
SN - 00192805
AB - Discusses a study on the appearance of hemolytic complement activity in the sera of embryonic sheep. Whole complement activity in sera of fetal lambs discovered after the 123rd day of gestation; Description of the hemolytic C activity which depends on the presence of all the C components in the serum; Insensitivity of titres of hemolytic C to large variations in the concentration of some of the components.
KW - SHEEP
KW - LIVESTOCK
KW - HEMOLYSIS & hemolysins
KW - IMMUNITY
KW - BLOOD
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 13347662; Colten, H. R. 1 Silverstein, A. M. 1 Bonos, T. 1 Rapp, H. J. 1; Affiliation: 1: Biology Branch, National Cancer Institute, Maryland, the Wilmer Institute, Johns Hopkins Hospital, Baltimore, Maryland; Source Info: Sep68, Vol. 15 Issue 3, p459; Subject Term: SHEEP; Subject Term: LIVESTOCK; Subject Term: HEMOLYSIS & hemolysins; Subject Term: IMMUNITY; Subject Term: BLOOD; Subject Term: ANTIGEN-antibody reactions; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112410 Sheep Farming; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parloff, Morris B.
AU - Datta, Lois-Ellin
AU - Kleman, Marianne
AU - Handlon, Joseph H.
T1 - Personality characteristics which differentiate creative male adolescents and adults.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1968/12//
VL - 36
IS - 4
M3 - Article
SP - 528
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8933214; Parloff, Morris B. 1 Datta, Lois-Ellin 1 Kleman, Marianne 2 Handlon, Joseph H. 3; Affiliation: 1: National Institute of Mental Health. 2: California Department of Public Health, Berkeley. 3: Case Western Reserve University.; Source Info: Dec68, Vol. 36 Issue 4, p528; Number of Pages: 25p; Document Type: Article
L3 - 10.1111/1467-6494.ep8933214
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oppenheim, J. J.
AU - Rogentine, G. N.
AU - Terry, W. D.
T1 - The Transformation of Human Lymphocytes by Monkey Antisera to Human Immunoglobulins.
JO - Immunology
JF - Immunology
Y1 - 1969/01//
VL - 16
IS - 1
M3 - Article
SP - 123
EP - 138
PB - Wiley-Blackwell
SN - 00192805
AB - Cultures of human peripheral leucocytes were stimulated to incorporate tritiated thymidine when incubated with monkey antisera to human immunoglobulins. Twenty-five of forty-four monkey antisera were active and stimulated 90 per cent of leucocyte (WBC) cultures to incorporate a small but significantly greater amount of tritiated thymidine (TdR3H) than that incorporated by controls. This stimulation of TdR3H uptake correlated with an increase from 2 to 8 per cent lymphoblasts in the cultures. Leucocytes washed free of serum immunoglobulins responded to a greater degree to the anti-immunoglobulin sera than when they were cultured in the presence of human serum. Prior absorption of antisera with either whole serum or homologous immunoglobulin blocked anti-serum stimulation completely. The anti-IgG and anti-IgM antisera were consistently more effective than anti-IgA, anti-K and anti-A chain antisera. Sequential stimulation by antisera against two different immunoglobulins was not significantly different from those stimulated by only one of the two, Lymphocytes from three asymptomatic subjects with low or absent serum IgA levels transformed as well with anti-IgA as did lymphocytes from subjects with normal serum IgA levels. Antisera were cytotoxic to the lymphocytes only in the presence of complement. Presumably the transformation of human lymphocytes was due to a reaction of anti-immunoglobulin antisera with specific immunoglobulin antigenic determinants present on or in the circulating lymphocytes.
KW - LEUCOCYTES
KW - IMMUNE serums
KW - IMMUNOGLOBULINS
KW - BLOOD cells
KW - LYMPHOCYTES
KW - IMMUNOLOGY
N1 - Accession Number: 13350488; Oppenheim, J. J. 1 Rogentine, G. N. 1 Terry, W. D. 1; Affiliation: 1: National Institutes of Health, The National Institute of Dental Research, and the National Cancer Institute, Bethesda, Maryland; Source Info: Jan69, Vol. 16 Issue 1, p123; Subject Term: LEUCOCYTES; Subject Term: IMMUNE serums; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD cells; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frazier, Thomas W.
AU - Weil-Malherbe, Hans
AU - Lipscomb, Harry S.
T1 - PSYCHOPHYSIOLOGY OF CONDITIONED EMOTIONAL DISTURBANCES IN HUMANS.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1969/03//
VL - 5
IS - 5
M3 - Article
SP - 478
EP - 503
SN - 00485772
AB - A discriminative avoidance conditioning technique was used to study urinary excretion of selected adrenal hormones in response to a stimulus which had acquired conditioned noxious properties through association with availability of punishment. A four day test procedure was employed: (1) to habituate subjects to the test environment; (2) obtain control data; (3) condition subjects; and (4) test reactions to the conditioned noxious stimulus. Urine samples were taken at two-hour intervals preceding and following each of the four trials, and were analyzed for epinephrine, norepinephrine, total 17-hydroxycorticosteroids, and other urinary constituents. These results were correlated with results obtained from monitoring of heart rate, skin resistance, blood pressure, and three measures of panel monitoring performance. Data analyses revealed significant changes from control levels during the test period for each of the principal measures described above and some specification of life systems interrelationships through correlation and factor analyses. Factors were identified which related to behavioral efficiency, psychological effort, fluid transport regulation, cardiovascular-adrenal, and specific epinephrine and norepinephrine factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADRENAL cortex
KW - VIGILANCE (Psychology)
KW - AUTONOMIC conditioning
KW - PUNISHMENT (Psychology)
KW - Adrenal
KW - Autonomic
KW - Factor analysis
KW - Human avoidance conditioning
KW - Punishment. (T. Frazier)
KW - Vigilance
N1 - Accession Number: 11237629; Frazier, Thomas W. 1 Weil-Malherbe, Hans 2 Lipscomb, Harry S. 3; Affiliation: 1: Walter Reed Army Institute of Research. 2: National Institute of Mental Health, St. Elizabeth's Hospital. 3: Baylor University College of Medicine.; Source Info: Mar1969, Vol. 5 Issue 5, p478; Subject Term: ADRENAL cortex; Subject Term: VIGILANCE (Psychology); Subject Term: AUTONOMIC conditioning; Subject Term: PUNISHMENT (Psychology); Author-Supplied Keyword: Adrenal; Author-Supplied Keyword: Autonomic; Author-Supplied Keyword: Factor analysis; Author-Supplied Keyword: Human avoidance conditioning; Author-Supplied Keyword: Punishment. (T. Frazier); Author-Supplied Keyword: Vigilance; Number of Pages: 26p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paul, W. E.
AU - Thorbecke, G. Jeanette
AU - Siskind, G. W.
AU - Benacerraf, B.
T1 - The Effect of Dose in Tolerance Induction on the Subsequent Response to a Cross-Reactive Antigen.
JO - Immunology
JF - Immunology
Y1 - 1969/07//
VL - 17
IS - 1
M3 - Article
SP - 85
EP - 92
PB - Wiley-Blackwell
SN - 00192805
AB - The amount of antibody produced by BSA-tolerant rabbits as a result of immunization with DNP-BSA is dependent upon the amount of BSA used to induce tolerance. Tolerance was induced by initial injection of 100 μg of antigen followed by progressively higher doses. Rabbits rendered tolerant with a maximum BSA dose of 1 mg had a mean serum anti-BSA antibody concentration of 0·39 mg/ml after immunization with DNP-BSA, whereas rabbits rendered tolerant with a maximum BSA dose of 100 mg had a mean serum anti-BSA concentration of 0·02 mg after the same course of immunization. This compares with a mean of 1·08 mg of anti-BSA antibody in normal rabbits immunized with DNP-BSA. There was a similar reduction in the concentration of anti-DNP anti-bodies and of conjugate-specific antibodies in the tolerant groups. The results are discussed in terms of a thermodynamically-controlled induction of tolerance in individual precursor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - IMMUNIZATION
KW - RABBITS as laboratory animals
KW - ADMINISTRATION of drugs
KW - CELLS
KW - IMMUNOLOGY
N1 - Accession Number: 13354172; Paul, W. E. 1 Thorbecke, G. Jeanette 1 Siskind, G. W. 1 Benacerraf, B. 1,2,3; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 2: Department of Medicine and Pathology, New York University of Medicine, New York, U.S.A. 3: Department of Medicine, Cornell University Medical College, New York, N.Y., U.S.A.; Source Info: Jul69, Vol. 17 Issue 1, p85; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNIZATION; Subject Term: RABBITS as laboratory animals; Subject Term: ADMINISTRATION of drugs; Subject Term: CELLS; Subject Term: IMMUNOLOGY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simmons, William L.
AU - Tyler, Forrest B.
T1 - LENGTH OF HOSPITALIZATION AS A FUNCTION OF PATIENTS' CONCEPTIONS OF THERAPISTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1969/07//
VL - 25
IS - 3
M3 - Article
SP - 332
EP - 338
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study, which investigates whether differences among patients in relative degree of concern with task vs. personal characteristics of therapists are related to length of hospital stay. The results indicated that patients who conceptualized therapists more in terms of task activities and less in terms of personal characteristics spent significantly less time in the hospital arid had a significantly higher discharge rate than patients who conceptualized therapists more in terms of personal characteristics and less in terms of task activities.
KW - PSYCHIATRIC hospitals -- Length of stay
KW - PSYCHOTHERAPIST & patient
KW - PSYCHOTHERAPY patients
KW - MENTAL illness
KW - PSYCHIATRIC hospitals -- Admission & discharge
KW - MEDICAL personnel & patient
N1 - Accession Number: 15903638; Simmons, William L. 1 Tyler, Forrest B. 2; Affiliation: 1: American Psychological Association. 2: National Institute of Mental Health.; Source Info: Jul1969, Vol. 25 Issue 3, p332; Subject Term: PSYCHIATRIC hospitals -- Length of stay; Subject Term: PSYCHOTHERAPIST & patient; Subject Term: PSYCHOTHERAPY patients; Subject Term: MENTAL illness; Subject Term: PSYCHIATRIC hospitals -- Admission & discharge; Subject Term: MEDICAL personnel & patient; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frank, M. M.
AU - Humphrey, J. H.
T1 - Spontaneous Re-Aggregation of IgM Subunits and Restoration of Antibody Activity After Reduction and Alkylation of Rabbit Anti-Forssman Antibody.
JO - Immunology
JF - Immunology
Y1 - 1969/08//
VL - 17
IS - 2
M3 - Article
SP - 237
EP - 247
PB - Wiley-Blackwell
SN - 00192805
AB - Highly purified rabbit IgM anti-Forssman antibody, after reduction in dilute solution with 2-mercaptoethanol and alkylation with iodoacetamide, showed no diminution and often some increase in haemagglutination of sheep erythrocytes. The capacity to cause complement dependent lysis was, however, destroyed. It is shown that despite reduction and alkylation reaggregation of the subunits occurs to a variable extent producing non-covalently bound aggregates with S values ranging from 7 to more than 20. The aggregates can bind specifically to and agglutinate erythrocytes with greater effectiveness as their size increases. This spontaneous re-aggregation is not prevented by the presence of gelatin, but fails to occur when the IgM antibody is reduced in the presence of a variety of other proteins. The effect of extraneous proteins is evident only when they are present at the time of reduction or are added within 10–15 minutes. It is suggested that following rupture of the interchain disulphide bonds, the IgM molecule can undergo a complex, time-dependent rearrangement into new stable forms which retain combining site activity but do not involve covalent bonds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN G
KW - IMMUNOGLOBULINS
KW - CHEMICAL reduction
KW - ALKYLATION
KW - IMMUNOLOGY
KW - PROTEOMICS
N1 - Accession Number: 13355393; Frank, M. M. 1,2 Humphrey, J. H. 3; Affiliation: 1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 2: Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 3: National Institute, Medical Research, Mill Hill, London; Source Info: Aug69, Vol. 17 Issue 2, p237; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULINS; Subject Term: CHEMICAL reduction; Subject Term: ALKYLATION; Subject Term: IMMUNOLOGY; Subject Term: PROTEOMICS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adler, W. H.
AU - Curry, Jean H.
AU - Smith, R. T.
T1 - Immunoglobulin Peptidc Chain Synthesis in the Newborn Rabbit.
JO - Immunology
JF - Immunology
Y1 - 1969/09//
VL - 17
IS - 3
M3 - Article
SP - 457
EP - 468
PB - Wiley-Blackwell
SN - 00192805
AB - Lymphoid tissue from newborn rabbits was examined using fluorochrome conjugated goat antisera to rabbit γ, μ and α heavy chain and mixed light chain. Unimmunizcd newborn rabbits examined at intervals up to 20 days of age revealed a very low background of approximately one in 105 cells which stained with either the anti-μ, anti-γ or anti-L chain reagents. Newborn rabbits, immunized intrapcritoncally on the day of birth with S. paralyphi B (4, 5, 12:b), showed a 1000-fold increase in the number of stained cells; μ heavy chain containing cells were found 16 hours after immunization, and γ heavy chain containing cells were found 20 hours after immunization in the rabbit spleen tissue. The numbers of μ containing cells and γ containing cells were approximately equal at 5 days of age in tile immunized groups. No α heavy chain containing cells were found in any of tile rabbits studied. All cells which stained with the anti-μ or γ heavy chain reagent were also stained with the anti-light chain reagent. The cellular response of the immunized newborn rabbits could be inhibited by passive antibody to S. paralyphi B, either given at the time of immunization, or passively acquired from the doc. Specificity of inhibition was indicated by the failure of sheep red blood cells (SRBG) stroma to be inhibited in animals so suppressed. The range of cellular morphology of the γ chain containing and the μ chain containing cells was indistinguishable. The earliest cell to be stained with either anti-γ or anti-μ was a large blast-like cell with a thin rim of cytoplasm and a large nucleus. A full range of forms between this and typical plasma cells appeared later in each case. These findings present a paradox since γG antibody to this antigen does not appear in the serum of stroll animals following γM class in the usual sequence characteristic of adult animals. Possible explanations of this paradox arc explored. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNIZATION
KW - IMMUNITY
KW - IMMUNOGLOBULINS
KW - PLASMA cells
KW - IMMUNOLOGY
N1 - Accession Number: 14545579; Adler, W. H. 1,2 Curry, Jean H. 1 Smith, R. T. 1; Affiliation: 1: Department of Pathology, University of Florida, School of Medicine, Gainesville, Florida 32601 2: Research Fellow, Immunology (National Institute of Allergy and Infectious Diseases Training Grant 5T1-A1-128-06); Source Info: Sep69, Vol. 17 Issue 3, p457; Subject Term: ANTIGENS; Subject Term: IMMUNIZATION; Subject Term: IMMUNITY; Subject Term: IMMUNOGLOBULINS; Subject Term: PLASMA cells; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McIntire, K. R.
AU - Princler, G. L.
T1 - Prolonged Adjuvant Stimulation in Germ-Free BALB/c Mice: Development of Plasma Cell Neoplasia.
JO - Immunology
JF - Immunology
Y1 - 1969/09//
VL - 17
IS - 3
M3 - Article
SP - 481
EP - 487
PB - Wiley-Blackwell
SN - 00192805
AB - BALB/c mice develop a high incidence (60–80 per cent) of plasma cell tumour (PCT) following the introduction of mineral oil (MO) into the peritoneal cavity. Germ-free (GF) mice have a less developed lymphoreticular system, including a decreased number of plasma cells, than their conventional (CONV) counterparts. When GF BALB/c mice were injected i.p. with mineral oil they failed to develop the expected incidence of PCT. Only two of thirty-three GF mice (6 per cent) developed PCT, while twenty-four of thirty-one ex-GF (77 per cent) and twenty-eight of forty CONV BALB/c (70 per cent) developed PCT. The ex-GF and CONV mice had average times for PCT diagnosis of 11.3 and 11.5 months, but both GF tumours were discovered 18 months after mineral oil injection. Three groups of GF mice recieved three different sterile protein antigens along with MO and no PCT developed in these mice; in the GF group receiving MO along, both PCT arose. The GF mice in this experiment did develop a high incidence (80 per cent) of lymphoreticular neoplasms of a type more primitive than PCT. This experiment suggests the importance of microbial flora in the development and differentiation of the plasma cells which respond to a carcinogenic stimulus in a genetically susceptible host. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMA cells
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - MINERAL oils
KW - IMMUNOLOGY
N1 - Accession Number: 14545586; McIntire, K. R. 1 Princler, G. L. 1; Affiliation: 1: National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep69, Vol. 17 Issue 3, p481; Subject Term: PLASMA cells; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: MINERAL oils; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyatt, Richard
AU - Tursky, Bernard
T1 - SKIN POTENTIAL LEVELS IN RIGHT- AND LEFT-HANDED MALES.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1969/09//
VL - 6
IS - 2
M3 - Article
SP - 133
EP - 137
SN - 00485772
AB - From twelve left-handed and twelve right-handed males, skin potential levels were recorded simultaneously from both sides of the body. In both groups significantly higher skin potential levels were found on the right side. Unilateral stimuli and handedness did not unilaterally affect maximum response level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - HANDEDNESS
KW - MALES
KW - PSYCHOPHYSIOLOGY
N1 - Accession Number: 11049682; Wyatt, Richard 1 Tursky, Bernard 2; Affiliation: 1: National Institute of Mental Health, Bethesda 2: Massachusetts Mental Health Center; Source Info: Sep1969, Vol. 6 Issue 2, p133; Subject Term: SKIN; Subject Term: HANDEDNESS; Subject Term: MALES; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilcox, Michael
T1 - υ-Glutamyl Phosphate Attached to Glutamine-Specific tRNA.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1969/12/31/
VL - 11
IS - 3
M3 - Article
SP - 405
EP - 412
PB - Wiley-Blackwell
SN - 00142956
AB - B. subtilis Gln-tRNA formation, in vitro, involves the initial acceptance of glutamic acid by tRNAGln to form a missense Glu-tRNGln intermediate which is converted to Gln-tRNA by a subsequent amidation step, catalyzed by a specific amido-transferase, and requiring divalent cations, ATP, and L-glutamine or L-asparagine as amide donor. This reaction is associated with stoichiometric cleavage of glutamine and ATP to yield glutamic acid and Pi, respectively. Amidation proceeds via the formation of an activated intermediate which is shown to be γ-phospho-Glu-tRNAGln (P-γ-Glu-tRNAGln). P-γ-Glu-tRNAGln, bound to amido-transfcrase, is detected following incubation in the absence of amide donor. Subsequent addition of L-glutamine to the system leads to the rapid toss of the phosphate moiety from the intermediate concomitantly with the formation of Gln-tRNA, which is released from the enzyme. Consequences of the pathway, if it is duplicated in vivo, are the separation of the synthesis of glutamine destined for protein from that of free glutamine and, further, the coupling of the synthesis of the ammo acid with that, of protein. These implications are discussed with regard to their bearing on possible functions of the pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTAMYL-tRNA synthetase
KW - GLUTAMIC acid
KW - TRANSFER RNA
KW - ADENOSINE triphosphate
KW - TRANSFERASES
KW - AMIDES
KW - CATIONS
N1 - Accession Number: 13441939; Wilcox, Michael 1; Affiliation: 1: Laboratory of Biochemical Genetics, National Heart Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1969, Vol. 11 Issue 3, p405; Subject Term: GLUTAMYL-tRNA synthetase; Subject Term: GLUTAMIC acid; Subject Term: TRANSFER RNA; Subject Term: ADENOSINE triphosphate; Subject Term: TRANSFERASES; Subject Term: AMIDES; Subject Term: CATIONS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
T1 - The Immune Response in the Hamster II. STUDIES ON IgM.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 223
EP - 236
PB - Wiley-Blackwell
SN - 00192805
AB - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN M
KW - IMMUNE response
KW - ANTIGENIC determinants
KW - HAMSTERS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGICAL adjuvants
N1 - Accession Number: 13358132; Coe, J.E. 1; Affiliation: 1: United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Feb70, Vol. 18 Issue 2, p223; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNE response; Subject Term: ANTIGENIC determinants; Subject Term: HAMSTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGICAL adjuvants; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stashak, P. W.
AU - Baker, P. J.
AU - Roberson, B. S.
T1 - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice I. ASSAY OF NEUTRALIZING ANTIBODY BY A 50 PER CENT NEUTRALIZATION METHOD.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 295
EP - 305
PB - Wiley-Blackwell
SN - 00192805
AB - The experimental conditions most suitable for use in the assay of serum neutralizing antibody specific for bacteriophage φX174 by a 50 per cent neutralization method were investigated. Although assays conducted at 37° more readily revealed the presence of background neutralizing activity in the serum of non-immunized germ-free and conventionally reared mice, assays performed at 4° were more suitable for use in detecting the development of newly synthesized neutralizing antibody. In definitive experiments, the SD50 values obtained, i.e. the reciprocal of the serum dilution producing 50 per cent neutralization of added bacteriophage, were found to be directly proportional to the concentration of neutralizing antibody present in serum. The magnitude of the SD50 values obtained suggests that the procedure may be employed advantageously for the detection of very small amounts of antibody and in studies dealing with the kinetics of the antibody response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - BACTERIOPHAGES
KW - IMMUNOGLOBULINS
KW - MICE
KW - IMMUNE serums
KW - IMMUNOLOGY
N1 - Accession Number: 13358436; Stashak, P. W. 1 Baker, P. J. 2 Roberson, B. S. 3; Affiliation: 1: Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases 2: National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 3: Department of Microbiology University of Maryland, College Park, Maryland, U. S. A.; Source Info: Feb70, Vol. 18 Issue 2, p295; Subject Term: IMMUNE response; Subject Term: BACTERIOPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: MICE; Subject Term: IMMUNE serums; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stashak, P. W.
AU - Baker, P. J.
AU - Roberson, B. S.
T1 - The Serum Antibody Response to Bacteriophage φX174 in Germ-Free and Conventionally Reared Mice II. KINETICS OF THE SERUM ANTIBODY RESPONSE FOLLOWING PRIMARY IMMUNIZATION.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 307
EP - 317
PB - Wiley-Blackwell
SN - 00192805
AB - The kinetics of the serum antibody response to various amounts of bacteriophage φX174 were compared in germ-free and conventionally reared mice using a 50 per cent neutralization procedure for the assay of neutralizing antibody. Ten- and 100-fold increases in the amount of φX174 used to immunize resulted in seven and ten-fold increases, respectively, in the amount of antibody produced in conventionally reared mice; however, the same amounts of antigen produced only 1.3- and 1.9-fold increases in germ-free mice. Greater SD50 values, i.e. the reciprocal of the highest dilution of serum which neutralized 50 per cent of the added bacteriophage, were obtained in conventionally reared than germ-flee mice during the later stages of the antibody response; no other significant differences were noted in the kinetics of the response produced in both groups of animals immunized with high doses of antigen. However, neutralizing antibody was produced at a more rapid rate and in larger amounts in germ-free than conventionally reared mice immunized with a low dose of antigen. Regardless of the amount of antigen used to immunize, the time of onset of antibody formation was essentially the same (32-35 hours after injection) in both groups of mice. Conventionally reared mice eliminated antigen at half the rate observed in germ-free mice similarly immunized with high doses of φX174, but with low doses of antigen, no significant differences in elimination rate were noted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - BACTERIOPHAGES
KW - IMMUNOGLOBULINS
KW - MICE
KW - IMMUNE serums
KW - IMMUNOLOGY
N1 - Accession Number: 13358442; Stashak, P. W. 1 Baker, P. J. 2 Roberson, B. S. 3; Affiliation: 1: Laboratory of Microbiol Immunity, National Institute of Allergy and Infectious Diseases 2: National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 3: Department of Microbiology University of Maryland, College Park, Maryland, U.S.A.; Source Info: Feb70, Vol. 18 Issue 2, p307; Subject Term: IMMUNE response; Subject Term: BACTERIOPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: MICE; Subject Term: IMMUNE serums; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levine, S.
AU - Hoenig, E. M.
AU - Kies, Marian W.
T1 - ALLERGIC ENCEPHALOMYELITIS: IMMUNOLOGICALLY SPECIFIC INHIBITION OF CELLULAR PASSIVE TRANSFER BY ENCEPHALITOGENIC BASIC PROTEINS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1970/04//
VL - 6
IS - 4
M3 - Article
SP - 503
EP - 517
PB - Wiley-Blackwell
SN - 00099104
AB - Passive transfer of experimental allergic encephalomyelitis (EAE) was performed with lymph node cells from donor rats immunized with spinal cord or purified encephalitogenic basic protein and any of several adjuvant combinations. Transfer was inhibited by injection of recipients with the brain basic protein. Basic proteins from rat and guinea-pig CNS inhibited transfer from donors immunized with rat or guinea-pig spinal cord or basic protein. Monkey basic protein inhibited transfer from donors immunized with monkey or human cord. There was only partial cross-inhibition between rodent and primate groups. The inhibition was organ specific in that basic proteins from lung, spleen and adrenal did not inhibit transfer of EAE. Furthermore, transfer of adrenalitis from donors immunized with adrenal tissue was inhibited by adrenal extracts but not by CNS basic protein. Pertussis and typhoid vaccines injected into recipients inhibited transfer of either EAE or adrenalitis. This non-specific inhibition was also demonstrated after simultaneous transfer of both EAE and adrenalitis, whereas CNS basic protein eliminated only EAE in such recipients. Inhibition was complete in experiments terminated one day after transfer. In longer experiments, inhibition lasted only 3 or 4 days. Basic protein was rapidly cleared from the blood. Neither spleen nor adrenals were necessary for its action. Brain basic protein prevented the interaction between encephalitogenic cells and the target Organ by an immunologically specific mechanism which may be a type of desensitization. The inhibition could not be reproduced in vitro. Bioassay and radioactive tracers revealed that basic protein bound non-specifically to living or dead lymph node cells in vitro. The effects of incubation could be accounted for by this non-specific carry-over of basic protein into the recipients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENCEPHALOMYELITIS
KW - LYMPH
KW - DEMYELINATION
KW - PROTEINS
KW - CENTRAL nervous system -- Diseases
KW - LYMPHOID tissue
N1 - Accession Number: 14587029; Levine, S. 1,2 Hoenig, E. M. 1,2 Kies, Marian W. 1,2; Affiliation: 1: Pathology Department, New York Medical College Center for Chronic Disease. Bird S. Coler Hospital, Welfare Island, New York, New York. 2: Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland.; Source Info: Apr70, Vol. 6 Issue 4, p503; Subject Term: ENCEPHALOMYELITIS; Subject Term: LYMPH; Subject Term: DEMYELINATION; Subject Term: PROTEINS; Subject Term: CENTRAL nervous system -- Diseases; Subject Term: LYMPHOID tissue; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colten, H.R.
AU - Borsos, T.
AU - Rapp, H.J.
T1 - Isoelectric Focusing of Human and Guinea-Pig C2: Polymorphism of Guinea-Pig C2.
JO - Immunology
JF - Immunology
Y1 - 1970/04//
VL - 18
IS - 4
M3 - Article
SP - 467
EP - 472
PB - Wiley-Blackwell
SN - 00192805
AB - The isoelectric point (pI) of human and guinea-pig C2 was determined by electrofocusing. The results showed that human C2 and C2 of some guinea-pigs had a pi of approximately pH 5-5-5·6; in some guinea-pig sera C2 activity was resolved into two fractions, one with a pi of about 5·2 and the other of about 5·5. The data suggest the possibility that guinea-pig C2 may exist in at least two allotypic forms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPLEMENT (Immunology)
KW - BLOOD proteins
KW - ISOELECTRIC focusing
KW - GUINEA pigs
KW - IMMUNOLOGY
KW - SEPARATION (Technology)
N1 - Accession Number: 13358591; Colten, H.R. 1 Borsos, T. 1 Rapp, H.J. 1; Affiliation: 1: Biology Branch and the Immunology Section, Biology Branch National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Apr70, Vol. 18 Issue 4, p467; Subject Term: COMPLEMENT (Immunology); Subject Term: BLOOD proteins; Subject Term: ISOELECTRIC focusing; Subject Term: GUINEA pigs; Subject Term: IMMUNOLOGY; Subject Term: SEPARATION (Technology); NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Richard Q.
T1 - SLEEP CYCLES AND SKIN POTENTIAL IN NEWBORNS STUDIED WITH A SIMPLIFIED OBSERVATION AND RECORDING SYSTEM.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1970/05//
VL - 6
IS - 6
M3 - Article
SP - 778
EP - 786
SN - 00485772
AB - A simple visual observation system, supplemented by measurement of skin potential, was devised for developmental studies of sleep cycles in settings where multiple electrode placement is not practicable. The findings replicated essential features of quiet and active sleep cycles which had been reported previously to exist against the background of decreasing level of physiological arousal, as sleep proceeds. Twelve newborns showed approximately one-half of their interfeeding sleeping time in the rapid eye movement stage of sleep. Skin potential rapidly declined from the waking level, continued to decrease in level throughout sleep, increased in variability during REM sleep, and increased in level at the second waking period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GALVANIC skin response
KW - REFLEXES
KW - SLEEP
KW - NEWBORN infants
KW - ELECTROPHYSIOLOGY
KW - Newborns.
KW - Skin potential
KW - Sleep
N1 - Accession Number: 11049746; Bell, Richard Q. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: May1970, Vol. 6 Issue 6, p778; Subject Term: GALVANIC skin response; Subject Term: REFLEXES; Subject Term: SLEEP; Subject Term: NEWBORN infants; Subject Term: ELECTROPHYSIOLOGY; Author-Supplied Keyword: Newborns.; Author-Supplied Keyword: Skin potential; Author-Supplied Keyword: Sleep; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-8986.ep11049746
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moss, Howard A.
AU - Robson, Kenneth S.
T1 - THE RELATION BETWEEN THE AMOUNT OF TIME INFANTS SPEND AT VARIOUS STATES AND DEVELOPMENT OF VISUAL BEHAVIOR.
JO - Child Development
JF - Child Development
Y1 - 1970/06//
VL - 41
IS - 2
M3 - Article
SP - 509
EP - 517
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 10400249; Moss, Howard A. 1 Robson, Kenneth S. 1; Affiliation: 1: National Institute of Mental Health; Source Info: Jun1970, Vol. 41 Issue 2, p509; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paul, W.E.
AU - Siskind, G.W.
T1 - Hapten Specificity of Cellular Immune Responses as Compared with the Specificity of Serum Anti-hapten Antibody.
JO - Immunology
JF - Immunology
Y1 - 1970/06//
VL - 18
IS - 6
M3 - Article
SP - 921
EP - 930
PB - Wiley-Blackwell
SN - 00192805
AB - Comparative specificity data have been presented for the interaction of anti-hapten antibody with a series of structurally related haptens and for the stimulation by hapten-guinea pig albumin (GPA) conjugates of DNA synthesis in lymph node cell cultures from guinea pigs immunized with a given conjugate. A good correlation in the specificity of serum anti-hapten antibody and in the specificity of stimulation of DNA synthesis has been demonstrated. Thus, mutual serologic and stimulatory cross-reactivity exist between the aminocaproates and GPA conjugates of the p-iodophenysulfonyl and toluenesulfonyl groups. Poor or undetectable serologic and stimulatory cross reactivity exist in the other combinations tested. The data is consistent with the notion that the interaction of antigen with an antibody-like cellular receptor is crucial to the elicitation of cellular immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - IMMUNE response
KW - CELLULAR immunity
KW - ALBUMINS
KW - ANTIGENS
KW - IMMUNOLOGY
N1 - Accession Number: 13359421; Paul, W.E. 1 Siskind, G.W. 1; Affiliation: 1: Laboratory of Immunology, Nationai Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Medicine, Cornell University College of Medicine, New York, New York 10021; Source Info: Jun70, Vol. 18 Issue 6, p921; Subject Term: HAPTENS; Subject Term: IMMUNE response; Subject Term: CELLULAR immunity; Subject Term: ALBUMINS; Subject Term: ANTIGENS; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ugel, Arthur R.
AU - Idler, William
T1 - STRATUM GRANULOSUM: DISSECTION FROM CATTLE HOOF EPIDERMIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1970/11//
VL - 55
IS - 5
M3 - Article
SP - 350
EP - 353
SN - 0022202X
AB - A hairless area of epidermis is present on the posterior aspect of cattle hooves. When this area is excised the cut surfaces reveal three thick and well-demarcated cellular layers: 1) a glassy-clear stratum corneum; 2) the underlying epidermal cell layers; 3) the dermis. Microscopically, the stratum granulosum of this tissue averages 20 cells in thickness and is free of hair follicles, sebaceous and sweat glands. In view of the thickness of these cellular layers and the sharp demarcation between the stratum corneum and granular cell layers, it is possible by fine dissection to obtain sheets of fresh tissue which contain large amounts of keratohyalin. Such preparations are contaminated with variable amounts of cells from the stratum malpighii and dermal ridges, and small amounts of cornified and basal cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - SKIN
KW - TISSUES
KW - SWEAT glands
KW - HAIR follicles
KW - CELLS
N1 - Accession Number: 12260280; Ugel, Arthur R. 1 Idler, William 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland; Source Info: Nov70, Vol. 55 Issue 5, p350; Subject Term: EPIDERMIS; Subject Term: SKIN; Subject Term: TISSUES; Subject Term: SWEAT glands; Subject Term: HAIR follicles; Subject Term: CELLS; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260280
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuspa, Stuart H.
AU - Morgan, David L.
AU - Walker, Ruby J.
AU - Bates, Richard R.
T1 - THE GROWTH OF FETAL MOUSE SKIN IN CELL CULTURE AND TRANSPLANTATION TO F1 MICE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1970/12//
VL - 55
IS - 6
M3 - Article
SP - 379
EP - 389
SN - 0022202X
AB - A method for the monolayer culture of fetal mouse skin cells and the behavior of primary cultures have been described. The early cultures consist of discrete colonies of epidermoid cells with individual fibroblasts scattered between these foci. The cell colonies begin to produce a material which may be keratin by the third in vitro day. After one week in vitro the majority of epidermoid foci have degenerated and the cultures consist largely of elongated rapidly multiplying cells. When cells from cultures in vitro five days or less are transplanted back to the panniculus carnosus of F1 hosts, donor skin grows. This skin is hyperplastic but contains normal appendages and produces hair. These grafts have remained recognizable and stable for over four months. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - SKIN
KW - CELL culture
KW - CELLS
KW - FIBROBLASTS
KW - HAIR
N1 - Accession Number: 12260498; Yuspa, Stuart H. 1 Morgan, David L. 1 Walker, Ruby J. 1 Bates, Richard R. 1; Affiliation: 1: Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014.; Source Info: Dec70, Vol. 55 Issue 6, p379; Subject Term: MICE; Subject Term: SKIN; Subject Term: CELL culture; Subject Term: CELLS; Subject Term: FIBROBLASTS; Subject Term: HAIR; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260498
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BUCHSBAUM, MONTE
AU - STEVENS, S. S.
T1 - Neural Events and Psychophysical Law.
JO - Science
JF - Science
Y1 - 1971/04/30/
VL - 172
IS - 3982
M3 - Article
SP - 502
EP - 502
SN - 00368075
N1 - Accession Number: 85104565; BUCHSBAUM, MONTE 1; STEVENS, S. S. 2; Affiliations: 1: Unit on Psychophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Harvard University, Cambridge, Massachusetts 02138; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p502; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LIBET, B.
AU - WEIGHT, FoRRLST F.
T1 - Inactivation of Potassium Conductance in Slow Postsynaptic Excitation.
JO - Science
JF - Science
Y1 - 1971/04/30/
VL - 172
IS - 3982
M3 - Article
SP - 503
EP - 504
SN - 00368075
N1 - Accession Number: 85104567; LIBET, B. 1; WEIGHT, FoRRLST F. 2; Affiliations: 1: Department of Physiology, University of California, San Francisco 94122; 2: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p503; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Murphy, D. L.;
AU - Goodwin, F. K.;
AU - Bunney, W. E., Jr.;
T1 - Leukocytosis during lithium treatment
CT - Leukocytosis during lithium treatment
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1971/05/01/
VL - 127:11
IS - May
SP - 1559
EP - 1561
SN - 0002953X
AD - Section on Psychiatry, Laboratory of Clinical Sciences, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 8-3095; Language: English; Chemical Name: Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium; References: 20; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - An increase in circulating leukocytes accompanied lithium treatment in 28 consecutively studied manic-depressive patients. Acutely manic patients showed the most marked changes and maintained leukocyte counts of 10,000 to 14,000 during the first 2 to 4 weeks of lithium administration. Leukocyte counts returned to pre-lithium levels within one week after discontinuation of the drug. In 11 patients receiving lithium for longer periods, the elevation in white cell count persisted throughout treatment.
KW - Lithium--adverse reactions-;
KW - Drugs, adverse reactions--lithium--leukocytosis, in manic-depressive patients;
KW - Psychotherapeutic agents--lithium--adverse reactions, leukocytosis in manic-depressive patients;
KW - Toxicity--lithium--leukocytosis, in manic-depressive patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Henkin, R. I.;
T1 - Griseofulvin and dysgeusia: implications?
CT - Griseofulvin and dysgeusia: implications?
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/05/01/
VL - 74
IS - May
SP - 795
EP - 796
SN - 00034819
AD - Section on Neuroendocrinology, Experimental Therapeutics Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 8-4384; Language: English; Trade Name: Oxyphedrin--Ildamen; Generic Name: Oxyfedrine; Oxyfedrine; Chemical Name: Griseofulvin--126-07-8 Clofibrate--637-07-0 Lincomycin--154-21-2 Penicillamine--52-67-5 Phenindione--83-12-5 Oxyfedrine--15687-41-9; References: 9; Publication Type: Letters and Comments; Journal Coden: AIMEAS; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2 - Hypogeusia (decreased taste acuity) or dysgeusia (unpleasant or altered taste sensation) are important complications of drug therapy that have often been overlooked or disregarded by physicians. Hypogeusia has been reported after administration of clofibrate, lincomycin, D-penicillamine, and 5-mercaptopyridoxal. Altered taste acuity has been reported after administration of griseofulvin, phenindione, oxyphedrin (oxyfedrine) hydrochloride (Ildamen), acetyl sulfosalicylic acid, and several tranquilizers.
KW - Griseofulvin--toxicity-;
KW - Clofibrate--toxicity-;
KW - Lincomycin--toxicity-;
KW - Penicillamine--toxicity-;
KW - Mercaptopyridoxal--5--;
KW - Phenindione--toxicity-;
KW - Oxyfedrine--hydrochloride-;
KW - Acetyl sulfosalicylic acid--toxicity-;
KW - Toxicity--drugs--hypogeusia or dysgeusia, discussion;
KW - Tranquilizers--toxicity--altered taste acuity;
KW - Taste--drugs--with taste effects as complications;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yamamoto, R. S.;
AU - Weisburger, J. H.;
AU - Weisburger, E. K.;
T1 - Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors
CT - Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/05/01/
VL - 31
IS - May
SP - 483
EP - 486
SN - 00085472
AD - Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 9-2654; Language: English; References: 16; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Abstract Author: Jimmie L. Hall
N2 - This article reports the effects of various microsomal enzyme inducers (chlordane, phenobarbital, \b/-naphthoflavone, phenothiazine, and proadifen) and of metabolic inhibitors (dactinomycin, puromycin, and cycloheximide) on urethan carcinogenesis in mice.
KW - Urethan--carcinogenesis-;
KW - Carcinogens--urethan--carcinogenesis, in mice, effects of microsomal enzyme inducers and of metabolic inhibitors;
KW - Toxicity--urethan--carcinogenesis, in mice, effects of microsomal enzyme inducers and of metabolic inhibitors;
KW - Drugs--effects--of microsomal enzyme inducers and of metabolic inhibitors, on urethan carcinogenesis, in mice;
KW - Enzymes--inducers--microsomal, and metabolic inhibitors, effects on urethan carcinogenesis, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Milner, John E.
T1 - IN VITRO LYMPHOCYTE RESPONSE IN CONTACT HYPERSENSITIVITY II.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1971/05//
VL - 56
IS - 5
M3 - Article
SP - 349
EP - 352
SN - 0022202X
AB - Guinea pigs were sensitized to one of two contact allergens: diatrofluorobenzene (DNFB) and paraphylenediamine (PDA). Sensitization was accomplished by foot-pad injections of the uncojugated bapten in Freud's complete adjuvan. Lymphocytes from animals with contact hypersesitivity to DNFB or PDA were cultured in vitro with conjugates of guinea pig epidermal proteins with DNFB or PDA. Responses to these antigens as measured by incorporation of tritiated thymidine into DNA, indicated that lymphocyte transformation in vitro can distinguish between sensitivity to either of these allergens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - IMMUNOGLOBULINS
KW - LYMPHOCYTES
KW - DNA
KW - THYMIDINE
KW - GUINEA pigs
N1 - Accession Number: 12261204; Milner, John E. 1; Affiliation: 1: National Cancer Institute Research Career, Development Awardce, No. 1 K4 CA 33563-01, MB.; Source Info: May71, Vol. 56 Issue 5, p349; Subject Term: ALLERGY; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: DNA; Subject Term: THYMIDINE; Subject Term: GUINEA pigs; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261204
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simon, R. M.
T1 - STATIONARY PROPERTIES OF A TWO-ECHELON INVENTORY MODEL FOR LOW DEMAND ITEMS.
JO - Operations Research
JF - Operations Research
Y1 - 1971/05//May/Jun71
VL - 19
IS - 3
M3 - Article
SP - 761
EP - 773
PB - INFORMS: Institute for Operations Research
SN - 0030364X
AB - This paper considers a two-echelon inventory model for consumable or repairable parts in which the first-echelon facilities use one-for-one replenishment policies and the second-echelon facility uses a continuousreview (s, ,S) policy. Repair may be accomplished at all facilities. Repair and transportation times are assumed to be deterministic, and the failure processes that generate demands are assumed to be Poisson. The paper derives exact expressions for the stationary distributions of stock on hand, stock in repair, and backlogged demand at each facility, and indicates how these expressions may be utilized for optimization purposes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Operations Research is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMER goods
KW - INVENTORIES
KW - RETROFITTING
KW - DEMAND (Economic theory)
KW - DOWNTIME (Systems)
KW - MATHEMATICAL optimization
N1 - Accession Number: 8602270; Simon, R. M. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland.; Issue Info: May/Jun71, Vol. 19 Issue 3, p761; Thesaurus Term: CONSUMER goods; Thesaurus Term: INVENTORIES; Thesaurus Term: RETROFITTING; Thesaurus Term: DEMAND (Economic theory); Thesaurus Term: DOWNTIME (Systems); Thesaurus Term: MATHEMATICAL optimization; NAICS/Industry Codes: 532299 All Other Consumer Goods Rental; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Pfefferbaum, Adolf
AU - Buchsbaum, Monte
AU - Gips, James
T1 - ENHANCEMENT OF THE AVERAGE EVOKED RESPONSE TO TONE ONSET AND CESSATION.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1971/05//
VL - 8
IS - 3
M3 - Article
SP - 332
EP - 339
SN - 00485772
AB - Auditory average evoked responses (AERs) produced by tone onset (ON responses) and tone cessation (OFF responses) were studied in 14 normal adult subjects. When short (500 msec) tone bursts were presented widely spaced (2500 msec between tones), ON responses were large, in contrast to OFF responses, which were less than one-third their size. But when long tones (2500 msec) were succeeded by brief (500 msec) silences, OFF and ON responses were comparable in size. In addition to this observed effect of the ratio of the percent of time the tone was on to the percent of time the tone was off, control experiments suggested that increased duration of preceding interval, unexpectancy of stimulus occurrence, and decreased mean frequency of stimulus presentation all increase the amplitude of both OFF and ON responses. OFF responses were found to be more sensitive to stimulus spacing effects than ON responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUDITORY evoked response
KW - AUDITORY perception
KW - EVOKED potentials (Electrophysiology)
KW - FIGURE-ground perception
KW - PERCEPTION
KW - COGNITION
KW - auditory evoked response
KW - figure-ground reversal.
KW - off response
KW - stimulus expectancy
KW - stimulus frequency
N1 - Accession Number: 11051057; Pfefferbaum, Adolf 1 Buchsbaum, Monte 2 Gips, James 2; Affiliation: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda. 2: Unit of Psychophysiology, Laboratory of Psychology National Institute of Mental Health, Bethesda.; Source Info: May1971, Vol. 8 Issue 3, p332; Subject Term: AUDITORY evoked response; Subject Term: AUDITORY perception; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: FIGURE-ground perception; Subject Term: PERCEPTION; Subject Term: COGNITION; Author-Supplied Keyword: auditory evoked response; Author-Supplied Keyword: figure-ground reversal.; Author-Supplied Keyword: off response; Author-Supplied Keyword: stimulus expectancy; Author-Supplied Keyword: stimulus frequency; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-8986.ep11051057
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Schall, G.;
AU - Zeiger, L.;
AU - DiChiro, G.;
AU - Briner, W.;
AU - Matsen, F.;
T1 - Clinical comparison of two Tc 99\LC/m\UC/ tracers for brain scanning: pertechnetate vs labeled albumin
CT - Clinical comparison of two Tc 99\LC/m\UC/ tracers for brain scanning: pertechnetate vs labeled albumin
JO - Radiology
JF - Radiology
Y1 - 1971/05/01/
VL - 99
IS - May
SP - 361
EP - 368
AD - National Institutes of Health, Department of Nuclear Medicine, Clinical Center, Building 10, Rm 1B53, Bethesda, MD 20014, USA
N1 - Accession Number: 10-2853; Language: English; Chemical Name: Technetium Tc 99m albumin--0 Technetium Tc 99m pertechnetate--23288-61-1; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals technetium Tc 99m pertechnetate; References: 14; Journal Coden: RADLAX; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Technetium Tc 99m pertechnetate and Tc 99m albumin were injected at different times into 60 patients for radionuclide brain studies. In all, 12 out of 20 lesions were demonstrated with technetium Tc 99m pertechnetate and (15 out of 20) with Tc 99m albumin. There were 3 false positive with Tc 99m albumin. Of the 42 studies interpreted as normal with both agents, 27 were equal in quality. In 15 the Tc 99m albumin study was more difficult to interpret because of the confusing concentrations of the tracer in certain vascular structures. Technetium Tc 99m pertechnetate remains the agent of choice for routine screening work.
KW - Technetium Tc 99m albumin--comparison, technetium Tc 99m pertechnetate-;
KW - Technetium Tc 99m pertechnetate--comparison, technetium Tc 99m albumin-;
KW - Radiopharmaceuticals--technetium Tc 99m pertechnetate, comparison, technetium Tc 99m albumin--brain scanning, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - NEWS
AU - Ramos, Juan
T1 - Editorial notes.
JO - Social Casework
JF - Social Casework
Y1 - 1971/05//
VL - 52
IS - 5
M3 - Editorial
SP - 323
EP - 324
SN - 00377678
AB - Part of a special issue on the Chicano movement. The intention of this issue of 'Social Casework' is to inform social workers about the problems of Chicanos, so they can more effectively serve this long-suppressed, neglected minority.
KW - ETHNOLOGY -- United States
KW - MEXICAN Americans
KW - SOCIAL services
KW - PUBLIC welfare
KW - SOCIAL workers
KW - UNITED States
N1 - Accession Number: 15430352; Ramos, Juan 1; Affiliations: 1 : Office of Program Liaison National Institute of Mental Health Chevy Chase, Maryland.; Source Info: May71, Vol. 52 Issue 5, p323; Historical Period: 1971; Subject Term: ETHNOLOGY -- United States; Subject Term: MEXICAN Americans; Subject Term: SOCIAL services; Subject Term: PUBLIC welfare; Subject Term: SOCIAL workers; Subject: UNITED States; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Blumenfeld, Dennis E.
AU - Weiss, George H.
T1 - Merging from an Acceleration Lane.
JO - Transportation Science
JF - Transportation Science
Y1 - 1971/05//
VL - 5
IS - 2
M3 - Article
SP - 161
PB - INFORMS: Institute for Operations Research
SN - 00411655
AB - There have been many studies of the merging delay problem; that is, the problem of calculating delay to a vehicle at a stop sign, waiting to merge with a single stream of traffic. In this article, a model is presented for merging from an acceleration lane of finite length. An expression for the expected delay is given. A driver in an acceleration lane will try to match his speed to the traffic on the major road, in order to create gaps that are as large as possible. Failing to merge while moving in the acceleration lane, the motorist will decelerate to come to a stop at the end of the lane. The calculations suggest that the expected delay does not depend strongly on the length of the acceleration lane and that most of the merging occurs near the beginning of the lane.
KW - LANE lines (Roads)
KW - ACCELERATION (Mechanics)
KW - TRAFFIC signs & signals
KW - TRANSPORTATION
KW - TRAFFIC patterns
N1 - Accession Number: 4470646; Blumenfeld, Dennis E. 1 Weiss, George H. 2; Affiliation: 1: Traffic Studies Group, University College, London, England. 2: National Institutes of Health, Bethesda, Maryland.; Source Info: May71, Vol. 5 Issue 2, p161; Subject Term: LANE lines (Roads); Subject Term: ACCELERATION (Mechanics); Subject Term: TRAFFIC signs & signals; Subject Term: TRANSPORTATION; Subject Term: TRAFFIC patterns; NAICS/Industry Codes: 561990 All Other Support Services; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; NAICS/Industry Codes: 237310 Highway, Street, and Bridge Construction; NAICS/Industry Codes: 488990 Other support activities for transportation; NAICS/Industry Codes: 488999 All Other Support Activities for Transportation; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Meriwether, W. D.;
AU - Jangi, R. J.;
AU - Serpick, A. A.;
T1 - Deafness following standard intravenous dose of ethacrynic acid
CT - Deafness following standard intravenous dose of ethacrynic acid
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/05/03/
VL - 216
IS - May 3
SP - 795
EP - 798
AD - Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 8-2667; Language: English; Chemical Name: Ethacrynic acid--58-54-8; Therapeutic Class: (40:28); AHFS Class: Diuretics ethacrynic acid; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - Two nonuremic patients experienced neurosensory hearing loss after the intravenous administration of standard doses of ethacrynic acid. Both were receiving nontoxic doses of aminoglycoside antibiotics concurrently. Total deafness occurred within 15 minutes of the administration of ethacrynic acid and was not accompanied by vertigo, nausea, or vomiting. The impairment of hearing was clearly transient in one patient. In the other patient, results of histologic examination of the inner ear at the time of autopsy were normal.
KW - Ethacrynic acid--deafness-;
KW - Diuretics--ethacrynic acid--deafness, following standard I.V. dose, cases;
KW - Drugs, adverse reactions--ethacrynic acid--deafness, following standard I.V. dose, cases;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schimpff, S.;
AU - Satterlee, W.;
AU - Young, V. M.;
AU - Serpick, A.;
T1 - Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia
CT - Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/05/13/
VL - 284
IS - May 13
SP - 1061
EP - 1065
SN - 00284793
AD - National Cancer Institute-Baltimore Cancer Research Center, 3100 Wyman Park Drive, Baltimore, Maryland 21211
N1 - Accession Number: 9-1891; Language: English; Chemical Name: Carbenicillin--4697-36-3 Gentamicin--1403-66-3; Therapeutic Class: (8:12); AHFS Class: Antibiotics carbenicillin (8:12); AHFS Class: Antibiotics gentamicin; References: 16; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Seventy-five acutely ill, febrile patients with cancer and granulocytopenia were treated empirically with a combination of carbenicillin and gentamicin for presumed bacterial infection. Cultures taken before the initiation of antibiotics subsequently documented the presence of infection in 48 of these patients, of whom 21 were shown to have \IT/Pseudomonas aeruginosa \OK/infections. Fourteen of these patients with pseudomonas infections had complete improvement, 3 improved temporarily but later died of infection, 2 had no improvement, and 2 could not be evaluated. This antibiotic combination was less promising for the infections caused by other gram-negative bacteria, especially klebsiella. Superinfection occurred in 8 patients. Combination carbenicillin and gentamicin is of value as initial antibiotic therapy for suspected \IT/Ps. aeruginosa \OK/infection in granulocytopenic patients with cancer but only after careful examination and extensive culturing.
KW - Carbenicillin--and gentamicin-;
KW - Gentamicin--and carbenicillin-;
KW - Combined therapy--carbenicillin and gentamicin--in presumed bacterial sepsis, in patients;
KW - Rational therapy--carbenicillin and gentamicin--in presumed bacterial sepsis, in patients;
KW - Antibiotics--carbenicillin--and gentamicin, combined therapy, in presumed bacterial sepsis, in patients;
KW - Antibiotics--gentamicin--and carbenicillin, combined therapy, in presumed bacterial sepsis, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BERNSTEIN, IRWIN D.
AU - THOR, DANIEL E.
AU - ZBAR, BERTON
AU - RAPP, HERBERT J.
T1 - Tumor hnmunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes.
JO - Science
JF - Science
Y1 - 1971/05/14/
VL - 172
IS - 3984
M3 - Article
SP - 729
EP - 731
SN - 00368075
AB - Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intradermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268349; BERNSTEIN, IRWIN D. 1; THOR, DANIEL E. 1; ZBAR, BERTON 1; RAPP, HERBERT J. 1; Affiliations: 1: Biology Branch, National Cancer Institute and Laboratory of Virology and Rickettsiology, Division of Biologics Standards, Bethesda, Maryland 20014; Issue Info: 5/14/1971, Vol. 172 Issue 3984, p729; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLEIN, RONALD
AU - HERMAN, SHELDON
T1 - Precautions with Alkyl Mercury.
JO - Science
JF - Science
Y1 - 1971/05/21/
VL - 172
IS - 3985
M3 - Article
SP - 872
EP - 872
SN - 00368075
N1 - Accession Number: 85198691; KLEIN, RONALD 1; HERMAN, SHELDON 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 5/21/1971, Vol. 172 Issue 3985, p872; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kohn, Melvin L.
T1 - BUREAUCRATIC MAN: A PORTRAIT AND AN INTERPRETATION.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1971/06//
VL - 36
IS - 3
M3 - Article
SP - 461
EP - 474
SN - 00031224
AB - There is a small but consistent tendency for men who work in bureaucratic organizations to be more intellectually flexible, more open to new experience, and more self-directed in their values than are men who work in nonburcaucratic organizations. This may in port result from bureaucracies' drawing on a more educated work force. in larger part, though, it appear: to be a consequence of occupational conditions attendant on bureaucratization-notably, far greater job protections, somewhat higher income, and substantively more complex work. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BUREAUCRACY
KW - ORGANIZATIONAL sociology
KW - LABOR supply
KW - INCOME
KW - INTERORGANIZATIONAL relations
KW - INTELLECTUALS
KW - Administrative Processes and Organizational Variables
KW - Organizing
N1 - Accession Number: 14846358; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun71, Vol. 36 Issue 3, p461; Thesaurus Term: BUREAUCRACY; Thesaurus Term: ORGANIZATIONAL sociology; Thesaurus Term: LABOR supply; Thesaurus Term: INCOME; Thesaurus Term: INTERORGANIZATIONAL relations; Subject Term: INTELLECTUALS; Author-Supplied Keyword: Administrative Processes and Organizational Variables; Author-Supplied Keyword: Organizing; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Weiss, I. W.;
AU - Fisher, L.;
AU - Phang, J. M.;
T1 - Diphosphonate therapy in a patient with myositis ossificans progressiva
CT - Diphosphonate therapy in a patient with myositis ossificans progressiva
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/06/01/
VL - 74
IS - Jun
SP - 933
EP - 936
SN - 00034819
AD - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 8-3766; Language: English; Chemical Name: Calcium--7440-70-2; References: 12; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A young man with severe debility from myositis ossificans progressiva was treated with sodium etidronate, a diphosphonate known to reduce the rates of hydroxyapatite formation and dissolution. He showed progressive improvement while receiving therapy. Radiocalcium kinetics and metabolic balance studies documented the reduction of bone mineral accretion and resorption rates. A lack of change in body calcium balance during diphosphonate administration suggests that sodium etidronate can initiate the desired clinical effect without demineralizing skeletal bone.
KW - Etidronate--sodium-;
KW - Calcium--metabolism-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Newsome, D. A.;
AU - Wong, V. G.;
AU - Cameron, T. P.;
AU - Anderson, R. R.;
T1 - Steroid-induced mydriasis and ptosis
CT - Steroid-induced mydriasis and ptosis
JO - Invest. Ophthalmol.
JF - Invest. Ophthalmol.
Y1 - 1971/06/01/
VL - 10
IS - Jun
SP - 424
EP - 429
AD - Clinical Branch, National Eye Institute, National Institutes of Health, U. S. Dept. of Health, Education & Welfare, Bethesda, Maryland
N1 - Accession Number: 8-4176; Language: English; Trade Name: Decadron; Generic Name: Dexamethasone; Chemical Name: Dexamethasone--50-02-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- dexamethasone (52:00); AHFS Class: Solutions, ophthalmic dexamethasone; References: 9; Journal Coden: INOPAO; Section Heading: Toxicity; Pharmacology; Abstract Author: James W. Dungee
N2 - A study of the effect of 0.1% dexamethasone phosphate and various vehicle mixtures on the pupil size, width of palpebral fissure and intraocular pressure in a group of rhesus monkeys was made. The agents investigated in the study were dexamethasone (Decadron) in a vehicle mixture, the vehicle alone, some individual constituents of the vehicle, and dexamethasone in saline. Sterile sodium chloride 0.85% was used as a control. The solutions were administered both by subconjunctival injection and anterior chamber perfusion. The results seem to indicate that the ptosis and sometimes mydriasis is due to an effect of the vehicle and not the steroid.
KW - Dexamethasone--phosphate-;
KW - Steroids, cortico---dexamethasone--phosphate, side effects of mydriasis and ptosis due to vehicle, in monkeys;
KW - Toxicity studies--dexamethasone--phosphate, side effects of mydriasis and ptosis due to vehicle, in monkeys;
KW - Vehicles--dexamethasone--phosphate, responsible for mydriasis and ptosis, in monkeys;
KW - Solutions, ophthalmic--dexamethasone--phosphate, vehicle responsible for mydriasis and ptosis, in monkeys;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Murphy, D. L.;
AU - Bunney, W. E.;
T1 - Total body potassium change during lithium administration
CT - Total body potassium change during lithium administration
JO - J. Nerv. Ment. Dis.
JF - J. Nerv. Ment. Dis.
Y1 - 1971/06/01/
VL - 152
IS - Jun
SP - 381
EP - 389
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institutes of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20014
N1 - Accession Number: 9-0955; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 34; Journal Coden: JNMDAN; Human Indicator: Yes; Section Heading: Toxicity
N2 - Total body potassium decreased after 2 weeks of lithium administration in 12 of 13 depressed patients but increased in 6 or 7 manic patients treated under identical conditions. Lithium carbonate was administered on a nonrandomized double-blind basis in a dosage of 1.2-1.8 g./day calculated according to age and weight to give a blood level of about 1.2 meq./day. These opposite changes were statistically significant for each group of patients. In a smaller group of depressed patients followed for longer periods during lithium treatment, the potassium levels returned to pre-lithium values. The dependence of the direction of potassium change on the clinical state of the patient may be related to some previously described differences between manic and depressed patients and also to differences in the therapeutic response to lithium between the 2 groups. A whole body counting method for \SU/40\BS/K was used to measure the cumulative changes in total body potassium content during the initial 2 weeks of lithium administration.
KW - Lithium carbonate--toxicity-;
KW - Toxicity--lithium carbonate--effects, total body potassium, in patients;
KW - Psychotherapeutic agents--lithium carbonate--effects, total body potassium, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PITHA, JOSEF
AU - PITHA, PAULA M.
T1 - Antiviral Resistance by the Polyinosiiic Acid-Poly(l-vinylcytosine) Complex.
JO - Science
JF - Science
Y1 - 1971/06/11/
VL - 172
IS - 3988
M3 - Article
SP - 1146
EP - 1148
SN - 00368075
AB - The antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(I)-poly(C)], which is a potent interferon inducer, have been studied. Structural changes that modify the polymer backbone substantially, such as loops or 2' → 5' phosphodiester bonds, lead to decreased antiviral activity. Unexpectedly, however, the complex oj polyinosinic acid and poly(J-vinylcytosine), which is only a much more distantly related analog of poly(l) poly;(C), shows high activity. It is postulated that the high activity is related to the reduction of the charge! mass ratio and to the existence of this complex in an aggregated state; these are two factors that generally enhance the uptake of compounds by cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268477; PITHA, JOSEF 1; PITHA, PAULA M. 2; Affiliations: 1: Gerontology Research Center, National Institute of Child Health and Human Development, Baltimore City Hospitals, Baltimore, Maryland 21224; 2: Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; Issue Info: 6/11/1971, Vol. 172 Issue 3988, p1146; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GLENNER, G. G.
AU - TERRY, W.
AU - HARADA, M.
AU - ISERSKY, C.
AU - PAGE, D.
T1 - Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses.
JO - Science
JF - Science
Y1 - 1971/06/11/
VL - 172
IS - 3988
M3 - Article
SP - 1150
EP - 1151
SN - 00368075
AB - The sequences of the 35 and 36 amino-terminal amino acids of two purified amyloid fibril proteins have been determined. Results indicate that these two proteins are derived from homogeneous immunoglobulin light chains of variable region subgroup VKI. The relation between amyloidosis and immunoglobulins is thus more firmly established . [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268479; GLENNER, G. G. 1; TERRY, W. 1; HARADA, M. 1; ISERSKY, C. 1; PAGE, D. 1; Affiliations: 1: National Institutes of Health, Bethesda. Maryland 20014; Issue Info: 6/11/1971, Vol. 172 Issue 3988, p1150; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - LEVITAN, HERBERT
T1 - Salicylate: Effect on Membrane Permeability of Molluscan Neurons.
JO - Science
JF - Science
Y1 - 1971/06/18/
VL - 172
IS - 3989
M3 - Article
SP - 1245
EP - 1247
SN - 00368075
AB - Identified cells in the buccal ganiglion of the marine mnollusk Navanax inermis were exposed to salicylate (1 to 30 millimoles per liter) for short periods. Salicylate increased the permneability to potassiumii and decreased the permeability to chloride in a reversible, dose-dependent manner, producing a concomitant increase in membrane potential and a decrease in mnemnbrane resistance. These events would reduce the output from, (15 well as the effectiveness of synaptic input to, a particular neuron. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87499025; BARKER, JEFFERY L. 1; LEVITAN, HERBERT 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/18/1971, Vol. 172 Issue 3989, p1245; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GELB, LAWRENCE D.
AU - AARONSON, STUART A.
AU - MARTIN, MALCOLM A.
T1 - Heterogeneity of Murine Leukemia Virus in vitro DNA; Detection of Viral DNA in Mammalian Cells.
JO - Science
JF - Science
Y1 - 1971/06/25/
VL - 172
IS - 3990
M3 - Article
SP - 1353
EP - 1355
SN - 00368075
AB - Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of doublestranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells amid cells containing RNA ticmor virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85289235; GELB, LAWRENCE D. 1; AARONSON, STUART A. 2; MARTIN, MALCOLM A. 1; Affiliations: 1: Laboratory of Biology of Virutses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/25/1971, Vol. 172 Issue 3990, p1353; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - EISENMAN, JOSEPH S.
AU - EDINGER, HENRY M.
AU - BARKER, JEFFERY L.
AU - CARPENTER, DAVID 0.
T1 - Neuronal Thermosensitivity.
JO - Science
JF - Science
Y1 - 1971/06/25/
VL - 172
IS - 3990
M3 - Article
SP - 1360
EP - 1362
SN - 00368075
N1 - Accession Number: 85289238; EISENMAN, JOSEPH S. 1; EDINGER, HENRY M. 2; BARKER, JEFFERY L. 3,4; CARPENTER, DAVID 0. 3; Affiliations: 1: Mount Sinai School of Medicine, New York 10029; 2: Rockefeller University, New York 10021; 3: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 4: Electroencephalography Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; Issue Info: 6/25/1971, Vol. 172 Issue 3990, p1360; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Schall, G. L.;
AU - Anderson, L. G.;
AU - Wolf, R. O.;
AU - Herdt, J. R.;
AU - Tarpley, T. M.;
AU - \ET/;
T1 - Xerostomia in Sjorgren's syndrome. Evaluation by sequential salivary scintigraphy
CT - Xerostomia in Sjorgren's syndrome. Evaluation by sequential salivary scintigraphy
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/06/28/
VL - 216
IS - Jun 28
SP - 2109
EP - 2116
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0548; Language: English; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents sodium pertechnetate (78:00); AHFS Class: Radiopharmaceuticals sodium pertechnetate; References: 21; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Sequential salivary scintigraphy, or the visual recording with a gamma scintillation camera of the uptake, concentration, and excretion of \SU/99m\BS/Tc pertechnetate by the major salivary glands after the administration of sodium pertechnetate Tc 99m, was performed on 20 female patients with Sjogren's syndrome. The results were compared with those of other procedures currently used to evaluate xerostomia. The scintigraphic findings closely paralleled the results of the salivary flow-rate determinations and contrast sialography and the patients' clinical symptoms, but did not correlate with the finding of lymphocytic infiltration in lip biopsy specimens or the detection of the anti-salivary-duct antibody. The scintigraphic examination proved to be extremely sensitive in depicting small asymmetric differences in parotid gland activity and in monitoring the improvement in salivary gland function with immunosuppressive therapy. Sequential salivary scintigraphy appears to be an easy, safe, and objective means of evaluating xerostomia in patients with Sjogen's syndrome.
KW - Sodium pertechnetate--Tc 99m-;
KW - Diagnostic agents--sodium pertechnetate--Tc 99m, in evaluating xerostomia in females with Sjogen's syndrome by sequential salivary scintigraphy;
KW - Radiopharmaceuticals--sodium pertechnetate--Tc 99m, in evaluating xerostomia in females with Sjogen's syndrome by sequential salivary scintigraphy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Oren, M. E.
AU - Herberman, R. B.
T1 - DELAYED CUTANEOUS HYPERSENSITIVITY REACTIONS TO MEMBRANE EXTRACTS OF HUMAN TUMOUR CELLS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/07//
VL - 9
IS - 1
M3 - Article
SP - 45
EP - 56
PB - Wiley-Blackwell
SN - 00099104
AB - Autochthonous tumour cell membrane extracts produced delayed hypersensitivity reactions in patients with a variety of neoplastic diseases. When tested at low protein concentrations (⩽0.33 mg/0.1 ml), autochthonous tumour extracts produced positive reactions in 50% of non-anergic cancer patients. The same dose of autochthonous leucocyte membranes produced a significantly lower incidence of positive reactions (10%) in normal volunteers. In contrast, the cancer patients were less reactive than the normal volunteers to a battery of standard skin test antigens. In patients with acute lymphocytic leukaemia, positive reactions were more often obtained during remission. The protein concentration of the extracts was found to be an important factor in these studies. Extracts with high protein concentrations elicited positive reactions in both the patients and in the normal volunteers. It remains to be determined whether the reactions to the high protein concentrations are due to non-specific inflammation or to a low level of autoimmunity in both patients and controls. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - CELL membranes
KW - TUMORS
KW - CANCER
KW - CANCER patients
KW - LYMPHOCYTIC leukemia
KW - PROTEINS
N1 - Accession Number: 14555249; Oren, M. E. 1 Herberman, R. B. 1; Affiliation: 1: Immunology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Jul71, Vol. 9 Issue 1, p45; Subject Term: SKIN diseases; Subject Term: CELL membranes; Subject Term: TUMORS; Subject Term: CANCER; Subject Term: CANCER patients; Subject Term: LYMPHOCYTIC leukemia; Subject Term: PROTEINS; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Goodell, B.;
AU - Leventhal, B.;
AU - Henderson, E.;
T1 - Cytosine arabinoside in acute granulocytic leukemia
CT - Cytosine arabinoside in acute granulocytic leukemia
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/07/01/
VL - 12
IS - Jul-Aug
SP - 599
EP - 606
SN - 00099236
AD - Leukemia Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 9-4201; Language: English; Trade Name: Cytosine arabinoside--Ara-C; Generic Name: Cytarabine; Cytarabine; Chemical Name: Cytarabine--147-94-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cytarabine; References: 25; Journal Coden: CLPTAT; Section Heading: Drug Evaluations
N2 - Cytosine arabinoside (cytarabine; Ara-C) was administered to 49 patients with acute granulocytic leukemia between 1966 and 1969. Ara-C was given by 4 hour infusion at a dose of 70 to 150 mg./m.\SU/2\BS//day in repeated 4 day courses. Complete remissions were achieved in 42% of patients. Of patients receiving Ara-C as initial chemotherapy, 25% died during attempted induction and 25% attained complete remission; of patients who had received prior chemotherapy (irrespective of response), 67% achieved complete remission. Infection (73%) and hepatic dysfunction (44%) were common complications of therapy. Median duration of remission in 21 patients receiving weekly Ara-C at 75 mg./m.\SU/2\BS/ S.C. as maintenance chemotherapy was 5 months. Median survival in patients achieving remission with Ara-C was 17 months; patients failing induction with this drug lived a median of 6 months. Ara-C is an effective and well-tolerated chemotherapeutic agent in acute granulocytic leukemia.
KW - Cytarabine--leukemia-;
KW - Antineoplastic agents--cytarabine--leukemia, granulocytic, acute, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Martin, W. R.;
AU - Hoeldtke, R.;
T1 - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
CT - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/07/01/
VL - 12
IS - Jul-Aug
SP - 613
EP - 649
SN - 00099236
AD - The National Institute of Mental Health Addiction Research Center, and the United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 9-4369; Language: English; Trade Name: CI-572--BAY-4503; Generic Name: Profadol; Propiram; Chemical Name: Profadol--428-37-5 Propiram--15686-91-6; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics GPA-1657 (28:08); AHFS Class: Analgesics and antipyretics profadol (28:08); AHFS Class: Analgesics and antipyretics propiram; References: 29; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Toxicity; Investigational Drugs
N2 - GPA-1657, profadol hydrochloride (CI-572), and propiram fumarate (BAY-4503) are proposed as analgesics of low abuse potential since none will suppress but each will precipitate abstinence in morphine-dependent monkeys. GPA-1657 is not an antagonist in man but a typical morphine-like compound and is judged to have significant abuse potential. Profadol and propiram act as antagonists in man and precipitate abstinence in subjects dependent on 240 mg. of morphine per day. As agonists, profadol and propiram resemble morphine-like rather than nalorphine-like drugs, since both produce morphine-like subjective effects and physical dependence and suppress abstinence in subjects dependent on 60 mg. per day of morphine. Both were judged to have abuse potential. Propiram was judged to have somewhat less abuse potential than profadol, since it produces less euphoria and less physical dependence. The morphine antagonist properties of profadol and propiram are thought to be caused by the fact that they are morphine agonists with less intrinsic activity than morphine.
KW - GPA-1657--toxicity-;
KW - Profadol--hydrochloride-;
KW - Propiram--fumarate-;
KW - Toxicity--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW - Toxicity--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Toxicity--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW - Analgesics and antipyretics--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW - Analgesics and antipyretics--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Analgesics and antipyretics--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW - Dependence--GPA-1657--potential, studies, compared to profadol and propiram, in patients;
KW - Dependence--profadol--hydrochloride, potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Dependence--propiram--fumarate, potential, studies, compared to GPA-1657 and profadol, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Baker, A. R.
AU - Borsos, T.
AU - Clten, H.R.
T1 - Cytotoxic Action of Antiserum and Complement: Quantification with a Colony Inhibition Method.
JO - Immunology
JF - Immunology
Y1 - 1971/07//
VL - 21
IS - 1
M3 - Article
SP - 33
EP - 43
PB - Wiley-Blackwell
SN - 00192805
AB - Describes the application of the colony inhibition technique to the study of the mechanism of complement mediated injury to nucleated cells. Morphologic changes induced by complement mediated cell lysis; Kinetics of complement lysis of sensitized Chinese hamster lung (CHL) cells; Effect of dose and species of complement on cell lysis; Effect of temperature on sensitization of CHL cells; Antibody dose response curve. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE serums
KW - COMPLEMENT (Immunology)
KW - BLOOD proteins
KW - CELLS
KW - HAMSTERS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGY
N1 - Accession Number: 13362442; Baker, A. R. 1 Borsos, T. 2 Clten, H.R. 2; Affiliation: 1: Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston, Mass, 02115, U.S.A. 2: Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Jul71, Vol. 21 Issue 1, p33; Subject Term: IMMUNE serums; Subject Term: COMPLEMENT (Immunology); Subject Term: BLOOD proteins; Subject Term: CELLS; Subject Term: HAMSTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gips, James
AU - Pfefferbaum, Adolf
AU - Buchsbaum, Monte
T1 - USE OF A SMALL PROCESS CONTROL COMPUTER IN A PSYCHOPHYSIOLOGICAL LABORATORY.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1971/07//
VL - 8
IS - 4
M3 - Article
SP - 538
EP - 542
SN - 00485772
AB - The use of a classic LINC computer in a psychophysiological laboratory is described. A monitor system provides a standard framework for running and analyzing the experiments of several investigators. The monitor system allows the LINC to be run remotely via two push buttons and a CRT display. The LINC is used to simultaneously collect data and generate stimuli. The system is flexible, economical, and can be run by persons with no previous computer experience. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHOPHYSIOLOGY
KW - RESEARCH
KW - PROCESS control
KW - PERSONAL computers
N1 - Accession Number: 11050404; Gips, James 1 Pfefferbaum, Adolf 2 Buchsbaum, Monte 1; Affiliation: 1: Unit on Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda 2: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda; Source Info: Jul1971, Vol. 8 Issue 4, p538; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: RESEARCH; Subject Term: PROCESS control; Subject Term: PERSONAL computers; NAICS/Industry Codes: 334111 Electronic Computer Manufacturing; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-41058-010
AN - 2013-41058-010
AU - Waldrop, Mary F.
AU - Goering, Jacob D.
T1 - Hyperactivity and minor physical anomalies in elementary school children.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1971/07//
VL - 41
IS - 4
SP - 602
EP - 607
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Waldrop, Mary F., Section on Child Behavior, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-41058-010. PMID: 4997640 Partial author list: First Author & Affiliation: Waldrop, Mary F.; Section on Child Behavior, Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1970, San Francisco, CA, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Elementary Schools; Hyperkinesis; Physical Disfigurement. Minor Descriptor: Teachers. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 1971.
AB - Elementary school boys, whom their teachers had selected as being among the three most hyperactive in their classes, were found to have significantly more minor physical anomalies than boys selected as not being hyperactive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hyperactivity
KW - physical anomalies
KW - elementary school children
KW - teachers
KW - 1971
KW - Elementary Schools
KW - Hyperkinesis
KW - Physical Disfigurement
KW - Teachers
KW - 1971
DO - 10.1111/j.1939-0025.1971.tb03219.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LEMBERGER, LOUIS
AU - TAMARKIN, NORMAN R.
AU - AXELROD, JULIUS
AU - KOPIN, IRWIN J.
T1 - Delta-9-Tetrahydrocannabinol: Metabolism and Disposition in Long-Term Marihuana Smokers.
JO - Science
JF - Science
Y1 - 1971/07/02/
VL - 173
IS - 3991
M3 - Article
SP - 72
EP - 74
SN - 00368075
AB - Radioactively labeled delta-9-tetrahydrocannabinol (δ9THC) administered intravenously to chronic marihuana smokers disappeared from the blood plasma with a half-life of 28 hours as compared to 57 hours for nonusers of marihuana. Apparent volumes of distribution did not significantly difler between the two groups. Within 10 minutes after administration of δ9THC, 11-hydroxy- δ9THC is present in the plasma of nonusers and chronic users. This metabolite was also present in urine and feces of nonusers and long-term marihuana smokers. In addition, polar metabolites were excreted in urine and feces of both groups for more than 1 week. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159761; LEMBERGER, LOUIS 1; TAMARKIN, NORMAN R. 2; AXELROD, JULIUS 3; KOPIN, IRWIN J. 3; Affiliations: 1: Lahoratory of Clinical Science, National lmtitute of Mental Health, Bethesda, Maryland 20014. and Pharmacology-Toxicology Program. National lmtitute of General A1edical Sciences, Bethesda; 2: Division of Drug Treatment and Research, Veterans Administration Hospital Washington, D.C. 20422; 3: Lahoratory of Clinical Science, National Institute of Mental Health; Issue Info: 7/ 2/1971, Vol. 173 Issue 3991, p72; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DALE, DAVID C.
AU - BROWN, CLARENCE H.
AU - CARBONE, PAUL
AU - WOLFF, SHELDON M.
T1 - Cyclic Urinary Leukopoietic Activity in Gray Collie Dogs.
JO - Science
JF - Science
Y1 - 1971/07/09/
VL - 173
IS - 3992
M3 - Article
SP - 152
EP - 153
SN - 00368075
AB - The urinary activities for bone marrow colony formation were measured on consecutive 24-hour urine samples from two gray collie dogs with cyclic neutropenia and from two normal collies. The activity varied cyclically in the gray collies with a peak activity developing during the neutropenic phase, which antecedes the return of blood neutrophils. The activity fell to undetectable levels after the blood neutrophil counts returned to the normal range. The urine of normal dogs showed no activity. Since the dogs with cyclic neutropenia have been shown to have periodic hematopoiesis, these data suggest a regulatory hormonal role for the substance measured by this assay. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159790; DALE, DAVID C. 1; BROWN, CLARENCE H. 2; CARBONE, PAUL 2; WOLFF, SHELDON M. 3; Affiliations: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland-20014; 2: Medical Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases; Issue Info: 7/ 9/1971, Vol. 173 Issue 3992, p152; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILHORAT, THOMAS H.
AU - HAMMOCK, MARY K.
AU - FENSTERMACHER, JOSEPH D.
AU - RALL, DAVID P.
AU - LEVIN, VICTOR A.
T1 - Cerebrospinal Fluid Production by the Choroid Plexus and Brain.
JO - Science
JF - Science
Y1 - 1971/07/23/
VL - 173
IS - 3994
M3 - Article
SP - 330
EP - 332
SN - 00368075
AB - The production of cerebrospinal fluid and the transport of 24Na from the blood to the cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus monkeys. Choroid plexectomy reduced the production of cerebrospinal fluid by an average of 33 to 40 percent and the rate of appearance of 24Na in the cerebrospinal fluid and its final concentration were proportionately reduced. In both normal and plexectomized animals, 24Na levels were found to be markedly greater in the gray matter surrounding the ventricles and in the gray matter bordering the subarachnoid space. That sodium exchanges in these two general areas of the brain may be linked to the formation of the cerebrospinal fluid is discussed here. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159831; MILHORAT, THOMAS H. 1,2; HAMMOCK, MARY K. 3,4; FENSTERMACHER, JOSEPH D. 5; RALL, DAVID P. 5; LEVIN, VICTOR A. 6; Affiliations: 1: Office, Scientific Director, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland; 2: Department of Neurosurgery, Children's Hospital, Washington, D.C.; 3: Office, Scientific Director, National Institute of Neurological Diseases and Stroke; 4: Department of Neurosurgery, George Washington University, Washington, D.C.; 5: Office of Associate Scientific Director of Experimental Therapeutics, National Cancer Institute, Bethesda, Maryland; 6: Department of Neurology, Massachusetts Genieral Hospital, Boston; Issue Info: 7/23/1971, Vol. 173 Issue 3994, p330; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Herman, S.;
AU - Klein, R.;
T1 - Alkyl mercury: unsafe at any speed
CT - Alkyl mercury: unsafe at any speed
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/07/29/
VL - 285
IS - Jul 29
SP - 297
SN - 00284793
AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
N1 - Accession Number: 8-4306; Language: English; Chemical Name: Mercury--7439-97-6; References: 9; Publication Type: Correspondence; Journal Coden: NEJMAG; Section Heading: Environmental Toxicity; Abstract Author: Joan Lentine
N2 - A growing body of evidence suggests that alkyl mercury intoxication may have much broader and more subtle forms of expression than previously recognized. Present knowledge of the toxicology of alkyl mercurialism is derived from studies of acutely intoxicated persons, usually in epidemic situations. Little is known about the effects of sublethal doses on the body. A hazardous effect of mercury is that it may potentiate the toxic effects of other environmental substances. This is suggested by decreased activity of hepatic microsomal detoxification systems in vivo and in vitro, of rats exposed to relatively low levels of alkyl mercury.
KW - Mercury--alkyl-;
KW - Toxicity, environmental--mercury--alkyl, effects in humans;
KW - Drug interactions--mercury--potentiation, possible, of other environmental substances, in rats;
KW - Dosage--mercury--sublethal, effects in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mann, George V.
T1 - OBESITY, THE NUTRITIONAL SPOOK.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/08//
VL - 61
IS - 8
M3 - Article
SP - 1491
EP - 1498
PB - American Public Health Association
SN - 00900036
AB - A down-to-earth, refreshing approach to the problems of obesity and its handling is presented. Emphasis is placed on exercise in controlling obesity rather than on drugs, and the point is made that campaigns against obesity may be based on ill-understood data. More reason and less emotion are prescribed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health
KW - Nutrition
KW - Diseases
KW - Nutrition disorders
KW - Exercise
KW - Obesity
KW - Eating disorders
KW - Appetite disorders
KW - Body weight
N1 - Accession Number: 24845730; Mann, George V. 1,2; Affiliations: 1: Career Investigator, National Heart and Lung Institute, National Institutes of Health; 2: Associate Professor, Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Tennessee 37203; Issue Info: Aug1971, Vol. 61 Issue 8, p1491; Thesaurus Term: Health; Thesaurus Term: Nutrition; Thesaurus Term: Diseases; Subject Term: Nutrition disorders; Subject Term: Exercise; Subject Term: Obesity; Subject Term: Eating disorders; Subject Term: Appetite disorders; Subject Term: Body weight; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Steinberg, A. D.;
AU - Kaltreider, B. H.;
AU - Staples, P. J.;
AU - Goetzl, E. J.;
AU - Talal, N.;
AU - \ET/;
T1 - Cyclophosphamide in lupus nephritis: a controlled trial
CT - Cyclophosphamide in lupus nephritis: a controlled trial
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/08/01/
VL - 75
IS - Aug
SP - 165
EP - 171
SN - 00034819
AD - Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland) (reprints: J. L. Decker, Building 10, Room 9N218, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0352; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; References: 16; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Thirteen women with lupus nephritis were hospitalized for a 10-week double-blind therapeutic trial comparing oral cyclophosphamide with placebo. Concurrent corticosteroid therapy (up to 30 mg./day of prednisone) was permitted. Patients receiving cyclophosphamide had greater improvement than did placebo-treated patients in 5 indexes: anti-DNA antibodies, serum complement, urine sediment, proteinuria, and extrarenal disease. There was no difference in creatinine clearance. There was a strong positive correlation between cyclophosphamide dosage and number of indexes improved. Toxic side effects of cyclophosphamide were noted.
KW - Cyclophosphamide--nephritis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lee, H. G.;
AU - Cheever, A. W.;
AU - Fairweather, W. R.;
T1 - Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoni
CT - Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoni
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1971/08/01/
VL - 45
IS - Aug
SP - 147
EP - 155
AD - Laboratory of Parasitic Diseases, National Institute of Allergy & Infections Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-0371; Language: English; Language of Summary: fr; Chemical Name: Hycanthone--3105-97-3; References: 18; Journal Coden: BWHOA6; Section Heading: Preliminary Drug Testing
N2 - Groups of mice infected with each of several geographic strains of Schistosoma mansoni were treated with 1 of 4 selected drugs and parasiticidal effects were compared. Responses to treatment were generally similar among strains except in 2 trials involving a Puerto Rican strain that was unusually sensitive to hycanthone and relatively resistant to stibophen. Selective killing of male worms occurred consistently with lucanthone and hycanthone treatment. The use of portal perfusion rather than dissection to recover surviving worms appears to have been instrumental in allowing the relatively resistant female worms to be found, namely in the liver. The results indicate that strain differences in susceptibility to drugs do occur in \IT/S. mansoni\OK/, and apparent refractoriness or unusual sensitivity encountered in the field should be evaluated in the laboratory.
KW - Stibophen--effects-;
KW - Lucanthone--effects-;
KW - Hycanthone--effects-;
KW - Schistosomicides--hycanthone--effects, S. mansoni strains, in mice;
KW - Schistosomicides--lucanthone--effects, S. mansoni strains, in mice;
KW - Schistosomicides--stibophen--effects, S. mansoni strains, in mice;
KW - Schistosoma mansoni--resistance--in strains from different geographical locations, effects of drugs, in mice;
KW - Resistance--schistosomicides--Schistosoma mansoni strains, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J. B.
T1 - The Immune Response in the Hamster III. SELECTIVE INDUCTION OF CONCOMITANT ANTIBODY FORMATION AND UNRESPONSIVENESS IN THE 7Sγ1- AND 7Sγ2-GLOBULINS WITH SOLUBLE HEN EGG ALBUMIN.
JO - Immunology
JF - Immunology
Y1 - 1971/08//
VL - 21
IS - 2
M3 - Article
SP - 175
EP - 191
PB - Wiley-Blackwell
SN - 00192805
AB - Synthesis of antibody to hen egg albumin (HEA) was restricted to one of the 7S immunoglobulins (7Sγ1:globulin) when hamsters were inoculated with soluble HEA (HEA-saline). This selective induction occurred regardless of the amount of HEA-saline injected (0.001–5·0 mg) or the route of inoculation. In contrast, HEA in Freund's adjuvants induced synthesis of anti-HEA in both the 7Sγ1 - and 7Sγ2 -globulins, even when as little as 0.1 μg of HEA was used. Repeated inoculations of hamsters with HEA-saline increased or maintained 7Sγ1 antibody, but did not induce anti-HEA synthesis in the 7Sγ2 -globulins. The results of cell transfer experiments indicated that cells from HEA-saline treated hamsters were primed to synthesize 7Sγ1 anti-HEA and were specifically unresponsive for 7Sγ2 anti-HEA synthesis. Selective induction of antibody production and unresponsiveness, concomitantly, within different immunoglobulin classes suggests that different antibody induction mechanisms are utilized by these two immunoglobulin classes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINS
KW - IMMUNOGLOBULINS
KW - HAMSTERS
KW - IMMUNE response
KW - ANTIGENS
N1 - Accession Number: 13480522; Coe, J. B. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Aug71, Vol. 21 Issue 2, p175; Subject Term: ALBUMINS; Subject Term: IMMUNOGLOBULINS; Subject Term: HAMSTERS; Subject Term: IMMUNE response; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Feldman, R J
AU - Koniver, D A
T1 - Interactive searching of chemical files and structural diagram generation from wiswesser line notation
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1971/08//
VL - 11
IS - 3
M3 - Article
SP - 154
EP - 159
SN - 00219576
AB - An interactive search and retrieval system for wiswesser line notation (wln) has been implemented. The system employs bit screens, which are useful for filtering a file. The user can graphically specify a search request structure and immediately receive graphic information as the result of the search. Four fortran iv programs were developed to prepare bit screens for wln files, input the search request to generate the wln, iteratively search the wln bit screen file, and generate a two-dimensionald representation of the chemical structure directly from the wln.
N1 - Accession Number: ISTA0602858; Feldman, R J 1; Koniver, D A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: August 1971, Vol. 11 Issue 3, p154; Note: Update Code: 0600; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Bischoff, K. B.;
AU - Dedrick, R. L.;
AU - Zaharko, D. S.;
AU - Longstreth, J. A.;
T1 - Methotrexate pharmacokinetics
CT - Methotrexate pharmacokinetics
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/08/01/
VL - 60
IS - Aug
SP - 1128
EP - 1133
SN - 00223549
AD - Biomedical Engineering and Instrumentation Branch, Division of Research Services, and Laboratory of Chemical Pharmacology, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-0152; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 24; Journal Coden: JPMSAE; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2 - A pharmacokinetic model is presented to predict the detailed distribution and excretion of methotrexate in several mammalian species over a wide range of doses. Tissue to plasma distribution coefficients include linear and strong saturable (presumed dihydrofolate reductase) effect. Required parameters are measured directly or estimated on the basis of physiological principles for mice, rats, dogs, and man. The model contains multicompartment descriptions of the biliary system and the intestine based on physiologic principles. Phenomena, such as local differences in intestinal absorption, could be incorporated if sufficient data were available. The model predicts tissue concentrations in the subhuman species and also predicts observed plasma concentrations and urinary and fecal excretion in man. Numerous graphs are included.
KW - Methotrexate--pharmacokinetics-;
KW - Pharmacokinetics--methotrexate--models, prediction of distribution and excretion, in animals and man;
KW - Models--methotrexate--pharmacokinetics, prediction of distribution and excretion, in animals and man;
KW - Antineoplastic agents--methotrexate--pharmacokinetics, models, prediction of distribution and excretion, in animals and man;
KW - Drugs, body distribution--methotrexate--models, pharmacokinetics, in animals and man;
KW - Excretion--methotrexate--models, pharmacokinetics, in animals and man;
KW - Metabolism--methotrexate--models, pharmacokinetics, in animals and man;
KW - Dosage--methotrexate--pharmacokinetics, models, predicts distribution and excretion, in animals and humans;
KW - Tissue levels--methotrexate--models, pharmacokinetics, in animals and man;
KW - Blood levels--methotrexate--models, pharmacokinetics, in animals and man;
KW - Methodology--methotrexate--pharmacokinetics, model to predict distribution and excretion, in animals and humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Axelrod, J.;
T1 - Noradrenaline: fate and control of its biosynthesis
CT - Noradrenaline: fate and control of its biosynthesis
JO - Science
JF - Science
Y1 - 1971/08/13/
VL - 173
IS - Aug 13
SP - 598
EP - 606
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0254; Language: English; Trade Name: Noradrenaline--Adrenaline; Generic Name: Norepinephrine; Epinephrine; Chemical Name: Norepinephrine--51-41-2 Epinephrine--51-43-4; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents norepinephrine (12:12); AHFS Class: Sympathomimetic agents epinephrine; References: 103; Journal Coden: SCIEAS; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Anne Paula Thompson
N2 - This Nobel Prize lecture reviews research efforts in the field of noradrenaline (norepinephrine) and adrenaline (epinephrine) metabolism.
KW - Norepinephrine--metabolism-;
KW - Epinephrine--metabolism-;
KW - Sympathomimetic agents--norepinephrine--metabolism, research, review;
KW - Metabolism--norepinephrine--research, review;
KW - Research--norepinephrine--metabolism, review;
KW - Metabolism--epinephrine--research, review;
KW - Sympathomimetic agents--epinephrine--metabolism, research, review;
KW - Research--epinephrine--metabolism, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - DeVita, V. T., Jr.;
AU - Serpick, A. A.;
AU - Canellos, G. P.;
T1 - Treatment of advanced Hodgkin's disease with [1,3-bis](2-chloroethyl)-1-nitrosourea BCNU
CT - Treatment of advanced Hodgkin's disease with [1,3-bis](2-chloroethyl)-1-nitrosourea BCNU
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/08/26/
VL - 285
IS - Aug 26
SP - 475
EP - 479
SN - 00284793
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 9-0333; Language: English; Trade Name: BCNU; Generic Name: Carmustine; Chemical Name: Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine; References: 12; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - BCNU (carmustine) was used to treat 45 patients with far advanced, previously treated Hodgkin's disease. Twenty-one patients achieved an appreciable remission. Nineteen patients had a partial remission for 16.5 weeks. Two patients had complete remissions for 72 to 208 weeks respectively. Leukopenia occurred in 24 patients, and thrombocytopenia in 32. BCNU has activity against Hodgkin's disease even when the disease is resistant to standard chemotherapeutic agents, and it appears not to be cross resistant with the alkylating agents.
KW - Carmustine--Hodgkin's disease-;
KW - Antineoplastic agents--carmustine--Hodgkin's disease, therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PETCOFF, DARRELL G.
AU - STRAIN, S. MICHAEL
AU - BROWN, WILLIAM R.
AU - RIBI, EDGAR
T1 - Maihna: Identification of Cannab. oids by Centrifugal Chromatography.
JO - Science
JF - Science
Y1 - 1971/08/27/
VL - 173
IS - 3999
M3 - Article
SP - 824
EP - 826
SN - 00368075
AB - Components in extracts of marihuana and hashish have been identified by a chromatographic technique in which centrifugal force is used to accelerate the migration of samples through columns of densely packed microparticulate gel. Rapid qualitative analysis and an estimate of the amounts of cannabinoids present was achieved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002471; PETCOFF, DARRELL G. 1; STRAIN, S. MICHAEL 2; BROWN, WILLIAM R. 2; RIBI, EDGAR 2; Affiliations: 1: Ivan Sorvall, Inc. Instrument Research Laboratory, Hamilton, Montana 59840; 2: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840; Issue Info: 8/27/1971, Vol. 173 Issue 3999, p824; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Gralnick, H. R.;
AU - McGinniss, M.;
AU - Elton, W.;
AU - McCurdy, P.;
T1 - Hemolytic anemia associated with cephalothin
CT - Hemolytic anemia associated with cephalothin
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/08/30/
VL - 217
IS - Aug 30
SP - 1193
EP - 1197
AD - Hematology Service and Blood Bank, Clinical Center, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 9-0520; Language: English; Trade Name: Keflin; Generic Name: Cephalothin; Chemical Name: Cephalothin--153-61-7; Therapeutic Class: (8:12); AHFS Class: Antibiotics cephalothin; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - Two patients developed Coombs' positive hemolytic anemia while receiving cephalothin sodium (Keflin) therapy. This complication of cephalothin therapy is rare, and must be differentiated from the positive Coombs' reaction seen in the majority of patients receiving cephalothin. In these 2 patients, Coombs' positive hemolytic anemia developed within 7 days of the initiation of cephalothin therapy. The dosage of cephalothin sodium was not excessive (2 and 6 g.), and neither patient was azotemic. In both patients a specific anticephalothin antibody was demonstrated. In one patient, this was demonstrable in the serum and eluate, and in the other patient, only in the eluate. In addition, one patient had an antipenicillin antibody. In both patients, the antibody directed against cephalothin appeared to be IgG. In any patient receiving cephalothin, unexplained hemolysis must include a search for anticephalothin and antipenicillin antibodies on the red blood cell before the drug can be implicated in any hemolytic episode.
KW - Cephalothin--toxicity-;
KW - Toxicity--cephalothin--development of positive hemolytic anemia, in patient;
KW - Antibiotics--cephalothin--toxicity, development of positive hemolytic anemia, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ozarin, Lucy D.
AU - Feldman, Saul
T1 - IMPLICATIONS FOR HEALTH SERVICE DELIVERY: THE COMMUNITY MENTAL HEALTH CENTERS AMENDMENTS OF 1970.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/09//
VL - 61
IS - 9
M3 - Article
SP - 1780
EP - 1784
PB - American Public Health Association
SN - 00900036
AB - A report is presented on some changes that have occurred as a result of the Community Mental Health Centers Act of 1970. Data are offered on the number of centers funded by the end of June, 1970, on their operations, and on some of the effects they have had. The need to develop these beginnings in relation to comprehensive care is stressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical centers
KW - Constitutional amendments
KW - Medical care
KW - Community mental health services
KW - Health facilities
KW - Constitutions
KW - Community health services
N1 - Accession Number: 24845596; Ozarin, Lucy D. 1; Feldman, Saul 1; Affiliations: 1: Division of Mental Health Service Programs, National Institute of Mental Health, Rockville, MD; Issue Info: Sep1971, Vol. 61 Issue 9, p1780; Subject Term: Medical centers; Subject Term: Constitutional amendments; Subject Term: Medical care; Subject Term: Community mental health services; Subject Term: Health facilities; Subject Term: Constitutions; Subject Term: Community health services; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GIBSON, WILLIAM A.
T1 - Diagnostic Histochemistry.
JO - BioScience
JF - BioScience
Y1 - 1971/09//9/1/1971
VL - 21
IS - 17
M3 - Book Review
SP - 926
EP - 927
SN - 00063568
AB - The article reviews the book "Diagnostic Histochemistry," by F. T. Zugibe.
KW - Histochemistry
KW - Nonfiction
KW - Zugibe, F. T.
KW - Diagnostic Histochemistry (Book)
N1 - Accession Number: 32113469; GIBSON, WILLIAM A. 1; Affiliations: 1 : National Institute of Dental Research, National Institutes of Health, Bethesda, Md; Source Info: 9/1/1971, Vol. 21 Issue 17, p926; Subject Term: Histochemistry; Subject Term: Nonfiction; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Sample, W. F.
AU - Chretien, P. B.
T1 - THYMIDINE KINETICS IN HUMAN LYMPHOCYTE TRANSFORMATION: DETERMINATION OF OPTIMAL LABELLING CONDITIONS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/09//
VL - 9
IS - 3
M3 - Article
SP - 419
EP - 427
PB - Wiley-Blackwell
SN - 00099104
AB - The optimal conditions for assessing the rate of DNA synthesis by the incorporation of labelled thymidine in PHA-stimulated human lymphocytes were determined. Optimal labelling conditions could be sustained for only 3-4 hr. The exposure time was limited by both the failure to maintain saturating concentrations of exogenous thymidine and the deleterious affect of internal radiation. A linear incorporation of the label with time was not found to be a reliable criteria of optimal labelling conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYMIDINE
KW - LYMPHOCYTES
KW - PYRIMIDINE nucleotides
KW - DNA
KW - IMMUNOLOGY
KW - LEUCOCYTES
N1 - Accession Number: 17364427; Sample, W. F. 1 Chretien, P. B. 1; Affiliation: 1: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Sep71, Vol. 9 Issue 3, p419; Subject Term: THYMIDINE; Subject Term: LYMPHOCYTES; Subject Term: PYRIMIDINE nucleotides; Subject Term: DNA; Subject Term: IMMUNOLOGY; Subject Term: LEUCOCYTES; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mantel, Nathan
AU - Myers, Max
T1 - Problems of Convergence of Maximum Likelihood Iterative Procedures in Multiparameter Situations.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1971/09//
VL - 66
IS - 335
M3 - Article
SP - 484
SN - 01621459
AB - In multiparameter situations there are important problems of convergence in the solution of maximum likelihood iterative equations. Convergence may be critically dependent on the initial parameter estimates employed. These problems are indicated specifically for a model of exponentially-distributed lifetimes where the reciprocal of the exponential parameter is linearly dependent on various regressor variables. A strategy is suggested based on alternative use of observed or expected values for the sample second derivative of the log likelihood. For the examples shown the initial parameter estimates correspond to no effect for the regressor variables, this being equivalent in some cases to making an unweighted fit to the data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STOCHASTIC convergence
KW - ESTIMATION theory
KW - PARAMETER estimation
KW - MATHEMATICAL statistics
KW - ITERATIVE methods (Mathematics)
KW - NUMERICAL analysis
KW - EXPONENTIAL functions
N1 - Accession Number: 4607794; Mantel, Nathan 1; Myers, Max 1; Affiliations: 1: Mathematical Statiscian, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p484; Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: ESTIMATION theory; Thesaurus Term: PARAMETER estimation; Thesaurus Term: MATHEMATICAL statistics; Subject Term: ITERATIVE methods (Mathematics); Subject Term: NUMERICAL analysis; Subject Term: EXPONENTIAL functions; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sobel, Milton
AU - Weiss, George H.
T1 - Play-the-Winner Rule and Inverse Sampling in Selecting the Better of Two Binomial Populations.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1971/09//
VL - 66
IS - 335
M3 - Article
SP - 545
SN - 01621459
AB - In this article two sampling rules are analyzed for the problem of selecting the better of two binomial populations. The first is alternate sampling (vector-at-a. time) and the second is the "play-the-winner" rule introduced by Robbins [3], and discussed by Zelen [8]. The termination rule studied is inverse sampling. One result is that the probabilities of correct selection for these two methods of sampling are exactly equal. It is also found that the play-the-winner sampling is uniformly preferable to the vector-at-a-time sampling rule in the sense that for the same probability requirement the expected number of trials on the poorer population is always smaller. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORRELATION (Statistics)
KW - SAMPLING (Statistics)
KW - PROBABILITY theory
KW - DOCUMENTATION
KW - BINOMIAL distribution
KW - BINOMIAL theorem
KW - GUIDELINES
KW - VECTOR algebra
N1 - Accession Number: 4607859; Sobel, Milton 1; Weiss, George H. 2; Affiliations: 1: Professor, Department of Statistics, University of Minnesota, Minneapolis, Minn. 55455.; 2: Chief, Physical Sciences Laboratory, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p545; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: PROBABILITY theory; Thesaurus Term: DOCUMENTATION; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; Subject Term: GUIDELINES; Subject Term: VECTOR algebra; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Halperin, Max
AU - Gurian, Joan
T1 - A Note on Estimation in Straight Line Regression When Both Variables Are Subject to Error.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1971/09//
VL - 66
IS - 335
M3 - Article
SP - 587
SN - 01621459
AB - This article focuses on the estimation in straight line regression when both variables are subject to error. It says that consistency, is a large sample property and it is of interest to inquire concerning small sample properties of b under reasonable assumptions. In a recent article D.H. Richardson and De-min Wu presented among other things the results of such an investigation. In particular they presented analytical and numerical results on the expected value and mean square error of b under the assumptions described above.
KW - ESTIMATION theory
KW - ANALYSIS of variance
KW - REGRESSION analysis
KW - EXPECTED returns
KW - ERROR analysis (Mathematics)
KW - MATHEMATICAL statistics
KW - SAMPLING (Statistics)
KW - VARIABLES (Mathematics)
KW - NUMERICAL analysis
N1 - Accession Number: 4608131; Halperin, Max 1; Gurian, Joan 2; Affiliations: 1: Chief, Biometrics Research Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.; 2: Mathematical Statistician, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Sep71, Vol. 66 Issue 335, p587; Thesaurus Term: ESTIMATION theory; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: REGRESSION analysis; Thesaurus Term: EXPECTED returns; Thesaurus Term: ERROR analysis (Mathematics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: SAMPLING (Statistics); Subject Term: VARIABLES (Mathematics); Subject Term: NUMERICAL analysis; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Buchsbaum, Monte
AU - Pfefferbaum, Adolf
T1 - INDIVIDUAL DIFFERENCES IN STIMULUS INTENSITY RESPONSE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1971/09//
VL - 8
IS - 5
M3 - Article
SP - 600
EP - 611
SN - 00485772
AB - Differences in the rate of increase of average evoked response (AER) amplitude with increasing intensity of light flash stimuli were studied in 80 male and 40 female college student volunteers. AERs to four intensities of light were recorded from the Ss and a measure of the rate of increase of AER amplitude with increasing stimulus intensity was obtained. Results from Ss tested twice, several weeks apart, showed that the slope of the amplitude intensity function was a stable individual characteristic. The observed amplitude intensity slope was greater in women than in men; vertex-ear leads showed lower slopes than vertex-occiput leads; subject handedness or hemisphere of lead derivation had little effect. Twenty extreme Ss, 10 individuals with the greatest slopes and 10 individuals with an actual decrease in AER amplitude with increasing stimulus intensity (negative slopes), were studied in greater detail. The amplitude-intensity slope was more affected by the absolute intensity of the light than the interstimulus interval or habituation effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVOKED response audiometry
KW - VISUAL evoked response
KW - BRIGHTNESS perception
KW - ELECTROENCEPHALOGRAPHY
KW - Average evoked response
KW - EEG
KW - Habituation
KW - Light intensity
KW - Perceptual style.
KW - Visual evoked response
N1 - Accession Number: 11052617; Buchsbaum, Monte 1 Pfefferbaum, Adolf 2; Affiliation: 1: Unit on Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda. 2: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda.; Source Info: Sep1971, Vol. 8 Issue 5, p600; Subject Term: EVOKED response audiometry; Subject Term: VISUAL evoked response; Subject Term: BRIGHTNESS perception; Subject Term: ELECTROENCEPHALOGRAPHY; Author-Supplied Keyword: Average evoked response; Author-Supplied Keyword: EEG; Author-Supplied Keyword: Habituation; Author-Supplied Keyword: Light intensity; Author-Supplied Keyword: Perceptual style.; Author-Supplied Keyword: Visual evoked response; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1469-8986.ep11052617
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06143-025
AN - 2006-06143-025
AU - Huxley, Matthew
T1 - The Dream Dwellers.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1971/09//
VL - 16
IS - 9
SP - 578
EP - 579
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06143-025. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Huxley, Matthew; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Dream Analysis; Dream Content; Dreaming; Imagination; Opiates. Classification: Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Hayter, Alethea. Opium and the Romantic Imagination=Berkeley, Calif.: University of California Press, 1970. Pp. 388. $7.50 cloth; $3.45 paper; 1970. Page Count: 2. Issue Publication Date: Sep, 1971.
AB - Reviews the book, Opium and the Romantic Imagination by Alethea Hayter (1970). This book is organized into three major sections, Setting, Theory; Practice; and a conclusion; Verdict. The author seeks to isolate those elements in the verbal and visual images and dreams of opium-addict writers which were not common to the dreams of other contemporary writers. To these nineteenth century Romantics, dreams were a revelation of a reality which could form and influence waking life, while the dream process was a parallel and model of the process of poetic creation. Urbane, informative, and admirably written, the book makes clear why Alethea Hayter is a Fellow of the Royal Academy of Literature. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Romantics
KW - dream dwellers
KW - dream process
KW - opium
KW - imagination
KW - 1971
KW - Dream Analysis
KW - Dream Content
KW - Dreaming
KW - Imagination
KW - Opiates
KW - 1971
U2 - Hayter, Alethea. (1970); Opium and the Romantic Imagination; Berkeley, Calif.: University of California Press, 1970. Pp. 388. $7.50 cloth; $3.45 paper
DO - 10.1037/0011424
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Grafius, Melba A.
AU - Bond, Howard E.
AU - Millar, David B.
T1 - Acetylcholinesterase Interaction with a Lipoprotein Matrix.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1971/09/02/
VL - 22
IS - 3
M3 - Article
SP - 382
EP - 390
PB - Wiley-Blackwell
SN - 00142956
AB - The nature of the components and some of the association forces in aggregated acetylcholinesterase, extracted from the electric organ of Electrophorus electricus, were investigated. The aggregated acetylcholinesterase (rapidly sedimenting, 70 S, and referred to as fast acetylcholinesterase) and the dissociated or "monomer" acetylcholinesterase (11.5 S and referred to as slow acetylcholinesterase) were isolated by zonal centrifugation. The fast acetylcholinesterase was further processed by gel filtration, resulting in a fast acetylcholinesterase of low specie activity and a slow acetylcholinesterase of high specie activity and a lowered sedimentation value (10.8 S). The fast acetylcholinesterase was exposed to the hydrolytic action of various enzymes (neuraminidase, hyaluronidase, alkaline phosphatase, and phospholipase A) and examined by sucrose gradient centrifugation techniques with no effect observed on the aggregation. However, phospholipases C and D and pancreatic lipase dissociated the fast acetylcholinesterase to the slow acetylcholinesterase (11.5 S). With phospholipase C, but not pancreatic lipase, the acetylcholinesterase was released from a matrix of ultraviolet absorbing, non-enzymatic material which remained in its aggregated form. With pancreatic lipase the matrix was also dissociated into a "monomer" species with a sedimentation value similar to that of the "monomer" acetylcholinesterase (resembling dissociation in high ionic strength). The hydrolytic action of the lipases did not alter the sedimentation value of the "monomer" nor its property of reversibly forming a gelatinous precipitate at pH 4.0. However, the slow acetylcholinesterase recovered from the gel column was not sensitive to the acid pH. The results indicate that the aggregated or fast acetylcholinesterase is a complex between "monomer" and a matrix of lipoproteins which, in itself, is an aggregation of molecular species similar in sedimentation value to the "monomer" acetylcholinesterase. A model is presented. Comparison between the matrix and the receptor protein is made. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIPOPROTEINS
KW - ACETYLCHOLINESTERASE
KW - CHOLINESTERASES
KW - ELECTROPHORI
KW - CARRIER proteins
KW - MONOMERS
N1 - Accession Number: 13473769; Grafius, Melba A. 1 Bond, Howard E. 1 Millar, David B. 1; Affiliation: 1: Laboratory of Physical Biochemistry, Environmental Biosciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland and National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1971, Vol. 22 Issue 3, p382; Subject Term: LIPOPROTEINS; Subject Term: ACETYLCHOLINESTERASE; Subject Term: CHOLINESTERASES; Subject Term: ELECTROPHORI; Subject Term: CARRIER proteins; Subject Term: MONOMERS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shapiro, Lucille
AU - Agabian-Keshishian, Nina
AU - Bendis, Ina
T1 - Bacterial Differentiation.
JO - Science
JF - Science
Y1 - 1971/09/03/
VL - 173
IS - 4000
M3 - Article
SP - 884
EP - 892
SN - 00368075
N1 - Accession Number: 85362786; Shapiro, Lucille 1; Agabian-Keshishian, Nina 2; Bendis, Ina 2; Affiliations: 1: Assistant professor of molecular biology, department of molecular biology, division of biological sciences, Albert Einstein College of Medicine, New York; 2: National Institutes of Health predoctoral trainees, same department; Issue Info: 9/ 3/1971, Vol. 173 Issue 4000, p884; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSHILBOUM, RICHARD
AU - AXELROD, JULIUS
T1 - Serum Dopamine-ß -Hydroxylase: Decrease after Chemical Sympathectomy.
JO - Science
JF - Science
Y1 - 1971/09/03/
VL - 173
IS - 4000
M3 - Article
SP - 931
EP - 934
SN - 00368075
AB - Dopamine-ß-hydroxylase is an enzyme that is localized to catecholamine- containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine- ß-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-ß- hydroxylase activity arises from sympathetic nerve terminals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85362812; WEINSHILBOUM, RICHARD 1; AXELROD, JULIUS 2; Affiliations: 1: Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institiute of Mental Health, Bethesda, Maryland 20014; Issue Info: 9/ 3/1971, Vol. 173 Issue 4000, p931; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RAPOPORT, STANLEY I.
AU - HORI, MASAHARU
AU - KLATZO, IGOR
T1 - Reversible Osmotic Opening of the Blood-Brain Barrier.
JO - Science
JF - Science
Y1 - 1971/09/10/
VL - 173
IS - 4001
M3 - Article
SP - 1026
EP - 1028
SN - 00368075
AB - Reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which difler in chemical and ionic properties. These agents may osmotically shrink barrier cells, possibly the vascular endothelium, and reversibly open spaces between them. Lipid-soluble nonelectrolytes damage the barrier irreversibly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87615549; RAPOPORT, STANLEY I. 1; HORI, MASAHARU 1; KLATZO, IGOR 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disease and Stroke, Bethesda 20014; Issue Info: 9/10/1971, Vol. 173 Issue 4001, p1026; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MACLEOD, COLIN
T1 - Ihternational Cooperation in Science.
JO - Science
JF - Science
Y1 - 1971/09/17/
VL - 173
IS - 4002
M3 - Article
SP - 1083
EP - 1083
SN - 00368075
N1 - Accession Number: 88002495; MACLEOD, COLIN 1; Affiliations: 1: Chairman, U.S. Delegation of the United States-Japan Cooperative Medical Science Committee, and HOWARD A. MINNERS, Secretariat, National Institutes of Health; Issue Info: 9/17/1971, Vol. 173 Issue 4002, following p1083; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PRIESTER, WILLIAM A.
T1 - Pet Cats and Pollutants.
JO - Science
JF - Science
Y1 - 1971/09/24/
VL - 173
IS - 4003
M3 - Article
SP - 1191
EP - 1191
SN - 00368075
N1 - Accession Number: 87615488; PRIESTER, WILLIAM A. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/24/1971, Vol. 173 Issue 4003, p1191; Number of Pages: 1/9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Li, F. P.;
AU - Nathan, D. G.;
T1 - Therapy-linked leukemia
CT - Therapy-linked leukemia
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1971/09/25/
VL - 3
IS - Sep 25
SP - 765
SN - 09598146
AD - Children's Hospital Medical Center, Children's Cancer Research Foundation and National Cancer Institute Field Station, Boston, Massachusetts
N1 - Accession Number: 9-1602; Language: English; Chemical Name: Oxymetholone--434-07-1; Therapeutic Class: (68:08); AHFS Class: Androgens oxymetholone; References: 6; Publication Type: Correspondence; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - Reports on the possibility of the development of acute leukemia following oxymetholone therapy of patients with aplastic anemia are presented.
KW - Oxymetholone--toxicity-;
KW - Androgens--oxymetholone--toxicity, possible, development of leukemia in patients with aplastic anemia;
KW - Toxicity--oxymetholone--possible, development of leukemia in patients with aplastic anemia;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Johnson, D. F.;
AU - Lamontagne, N. S.;
AU - Riggle, G. C.;
AU - Anderson, F. O.;
T1 - Tape controlled gradient elution chromatography system for steroid analysis
CT - Tape controlled gradient elution chromatography system for steroid analysis
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1971/10/01/
VL - 43
IS - Oct
SP - 1712
EP - 1715
AD - National Institutes of Health, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 9-0608; Language: English; References: 8; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry
N2 - A punched tape system for gradient pumping of solvent mixtures with an accuracy of 0.2% is described. The pumping system for delivering preselected volumes of eluting solvents and a solvent mixing chamber design which minimizes volume carry-over when solvent ratios are changed are described. Application to column separation of adrenocortical and ketosteroids is illustrated. Block diagrams of the electronic and pumping system are included.
KW - Chromatography--steroids, cortico---and ketosteroids, tape controlled gradient elution system;
KW - Steroids, cortico---chromatography--tape controlled gradient elution system;
KW - Automation, data processing--analysis--steroids, cortico-, and keto, tape controlled gradient elution chromatography system;
KW - Steroids--keto---chromatography, tape controlled gradient elution system;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Roth, J.;
AU - Prout, T. E.;
AU - Goldfine, I. D.;
AU - Wolfe, S. M.;
AU - Muenzer, J.;
AU - \ET/;
T1 - Sulfonylureas: effects in vivo and in vitro
CT - Sulfonylureas: effects in vivo and in vitro
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/10/01/
VL - 75
IS - Oct
SP - 607
EP - 621
SN - 00034819
AD - National Institute of Arthritis and Metabolic Diseases, Bldg. 10, Room 8-S-243, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0573; Language: English; References: 70; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology; Abstract Author: Judith A. Kepler
N2 - The University Group Diabetes Program is reviewed and studies confirming the direct multiple effects of sulfonylureas in many tissue sites outside of the beta cell are discussed.
KW - Sulfonylureas--effects--direct multiple, in tissue sites outside of beta cell;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Glynn, J. P.;
AU - Kende, M.;
T1 - Treatment of Moloney virus-induced leukemia with cyclophosphamide and specifically sensitized allogeneic cells
CT - Treatment of Moloney virus-induced leukemia with cyclophosphamide and specifically sensitized allogeneic cells
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/10/01/
VL - 31
IS - Oct
SP - 1383
EP - 1388
SN - 00085472
AD - Drug Evaluation Branch, Drug Research and Development, Chemotherapy, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-0127; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 24; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology; Abstract Author: Jimmie L. Hall
N2 - In this experiment, a combination of cyclophosphamide and immunotherapy with allogenic spleen cells was evaluated for antineoplastic effect against transplanted leukemia in mice. Cyclophosphamide followed within 4 to 6 hours by DBA/2 spleen cells from animals sensitized to Moloney virus yielded 44 long-term survivors out of 69 mice treated. This treatment was effective even though it was given only 2 to 6 days before the median survival time of untreated controls. No survivors were obtained with other forms of therapy.
KW - Cyclophosphamide--and immunotherapy-;
KW - Antineoplastic agents--cyclophosphamide--and immunotherapy, effects, against Moloney virus-induced leukemia, in mice;
KW - Combined therapy--cyclophosphamide and immunotherapy--effects, against Moloney virus-induced leukemia, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Straus, M. J.;
AU - Mantel, N.;
AU - Goldin, A.;
T1 - Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210
CT - Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/10/01/
VL - 31
IS - Oct
SP - 1429
EP - 1433
SN - 00085472
AD - Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-0113; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 25; Journal Coden: CNREA8; Section Heading: Pharmacology
N2 - This study was conducted to determine whether priming dose schedules of methotrexate could result in increased antileukemic effectiveness in mice. The results suggest that methotrexate has a greater percentage of cell kill at lower tumor cell populations. A cell cycle stage-specific agent such as methotrexate may kill a small percentage of tumor cells as the number of cells increases if there is either a corresponding decrease in growth fraction or an increase in mean generation time. In either case, a priming dose of methotrexate then may lower the tumor cell population sufficiently for subsequent low doses of the drug to kill more effectively.
KW - Methotrexate--dosage schedules-;
KW - Antineoplastic agents--methotrexate--dosage schedules, priming, effects, on mouse leukemia L1210 cells;
KW - Dosage schedules--methotrexate--priming, effects, on mouse leukemia L1210 cells;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Paul, W. E.
AU - Kask, Anne M.
T1 - Structural Control of Immunogenicity I. SYNTESIS OF OLIGO)-L-LYSINE PEPTIDES AND THEIR MONO-ε-DNP DERIVATIVES.
JO - Immunology
JF - Immunology
Y1 - 1971/10//
VL - 21
IS - 4
M3 - Article
SP - 575
EP - 582
PB - Wiley-Blackwell
SN - 00192805
AB - The synthesis of a series of oligo-L-lysines and mono-ε-DNP-oligo-L-lysines by Merrifield solid phase synthesis techniques has been described. The lysine utilized was protected at its α function by the highly acid-labile o-nitrophenyl-sulphenyl group and at its ε function by the benzyloxycarbonyl group. Thus, selective deprotection could be effected and the synthesis of the oligolysines was achieved with minimum side-product accumulation. The peptides were purified by ion exchange chromatography. More than twenty such compounds have been thus far prepared and have been utilized in the study of structural characteristics of immunogens and of the genetic control of the immune response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYSINE
KW - SOLID-phase synthesis
KW - IMMUNOLOGY
KW - PEPTIDES
KW - IMMUNE response
KW - ORGANIC synthesis (Chemistry)
KW - SYNTHESIS
N1 - Accession Number: 13363473; Paul, W. E. 1 Kask, Anne M. 1; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p575; Subject Term: LYSINE; Subject Term: SOLID-phase synthesis; Subject Term: IMMUNOLOGY; Subject Term: PEPTIDES; Subject Term: IMMUNE response; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: SYNTHESIS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yehudit Stupp
AU - W. E. Paul
AU - B. Benacerraf
T1 - Structural Control of Immunogenicity II. ANTIBODY SYNTHESIS AND CELLULAR IMMUNITY IN RESPONSE TO IMMUNIZATION WITH MONO-ε-OLICO-L-LYSINES.
JO - Immunology
JF - Immunology
Y1 - 1971/10//
VL - 21
IS - 4
M3 - Article
SP - 583
EP - 594
PB - Wiley-Blackwell
SN - 00192805
AB - A detailed evaluation of the capacity of mono-ε-DNP-oligo-L-lysines to initiate anti-DNP antibody synthesis and a state of delayed hypersensitivity in guinea-pigs is presented. Peptides containing as few as two lysine residues elicit the production of significant amounts of anti-DNP antibody when they are administered as Freund's complete adjuvant emulsions. Under these immunization conditions, the serum concentration of anti-DNP antibody is dependent on the chain length of the peptide, and on the amount and kind of mycobacteria in the adjuvant; guinea-pigs lacking the PLL gene produce amounts of anti-DNP antibody indistinguishable from that produced by guinea-pigs possessing this gene. On the other hand, when guinea-pigs are immunized with either 1-ε-DNP-tetra-L-lysine or 1-ε-DNP-nona-L-lysine without the use of mycobacterial adjuvant, anti-DNP antibody is produced only by guinea-pigs receiving the nona-L-lysine and only by those animals possessing the PLL gene. Delayed hypersensitivity results front immunizing PLL+ guinea-pigs with mono-ε-DNP-octa and nona-lysines but not from immunization with mono-εDNP-hexa-lysine; PLL- animals do not exhibit delayed hypersensitivity to any of these compounds. The data suggest that antibody synthesis to positively charged compounds may proceed as a result of formation of charge complexes with mycobacterial proteins; under such immunization conditions the intrinsic immunogenicity of a compound is more reliably revealed by the induction or elicitation of cellular immune responses. On this basis, a definite discontinuity in the degree of immunogenicity of the mono-ε-DNP-oligo-L-lysines occurs as the peptides are lengthened from six to eight residues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYSINE
KW - IMMUNOGLOBULINS
KW - ORGANIC synthesis (Chemistry)
KW - GUINEA pigs
KW - CELLULAR immunity
KW - IMMUNIZATION
N1 - Accession Number: 13363499; Yehudit Stupp 1 W. E. Paul 2 B. Benacerraf 3; Affiliation: 1: Department of Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 3: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p583; Subject Term: LYSINE; Subject Term: IMMUNOGLOBULINS; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: GUINEA pigs; Subject Term: CELLULAR immunity; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stupp, Yehudit
AU - Paul, W. E.
AU - Benacerraft, B.
T1 - Structural Control of Immunogenicity III. PREPARATION FOR THE ELICITATION OF ANAMNESTIC ANTIBODY RESPONSES BY OLIGO- AND POLY-LYSINES AND THEIR DNP DERIVATIVES.
JO - Immunology
JF - Immunology
Y1 - 1971/10//
VL - 21
IS - 4
M3 - Article
SP - 595
EP - 603
PB - Wiley-Blackwell
SN - 00192805
AB - A complete evaluation of the immunogenicity of oligo-L-lysines and their mono-ε-DNP derivatives requires a determination of their capacity to prepare animals for secondary responses to a highly immunogenic analogue and to elicit secondary responses in animals prepared with such an analogue. It is shown here that 1-ε-DNP-tetra-L-lysine is not effective, or only marginally effective, in preparing PLL+ guinea-pigs for secondary anti-DNP responses to DNP-poly-L-lysine whereas 1-ε-DNP-nona-L-lysine is active in such preparation. Similarly, in animals primed to DNP-ovalbumin, supplemental immunization with tetra-L-lysine is not effective in preparing strain 2 guinea-pigs for a secondary anti-DNP response to DNP-poly-L-lysine whereas both nona-L-lysine and poly-L-lysine are effective, the latter to a considerably greater degree. In animals primed with DNP-poly-Llysine or with DNP-ovalbumin and poly-L-lysine, DNP-poly-L-lysine elicits secondary anti-DNP responses whereas neither 1-ε-DNP-nona-L-lysine or 1-εDNP-tetra-L-lysine do. The data indicate that a hierarchy in the degree of immunogenicity exists within the lysyl peptides series with poly-L-lysine more immunogenic than nona-L-lysine and this, in turn, more immunogenic than tetra-L-lysine which is either nonimmunogenic or marginally immunogenic. Further, the determination of immunogenicity is a feature either of the 'helper' cell population or of a step in the response which is prior to the activation of 'helper' cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYSINE
KW - IMMUNOGLOBULINS
KW - GUINEA pigs
KW - IMMUNIZATION
KW - IMMUNE response
KW - DINITROBENZENES
N1 - Accession Number: 13363523; Stupp, Yehudit 1 Paul, W. E. 2 Benacerraft, B. 3; Affiliation: 1: Department of Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 3: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, Israel; Source Info: Oct71, Vol. 21 Issue 4, p595; Subject Term: LYSINE; Subject Term: IMMUNOGLOBULINS; Subject Term: GUINEA pigs; Subject Term: IMMUNIZATION; Subject Term: IMMUNE response; Subject Term: DINITROBENZENES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paul, W. E.
AU - Stupp, Yehudit
AU - Siskind, G. W.
AU - Benacerraf, B.
T1 - Structural Control of Immunogenicity IV. RELATIVE SPECIFICITY OF ELICITATION OF CELLULAR IMMUNE RESPONSES AND OF LIGAND BINDING TO ANTI-HAPTEN ANTIBODY AFTER IMMUNIZATION WITH MONO-ε-DNP-NONA-L-LYSINE.
JO - Immunology
JF - Immunology
Y1 - 1971/10//
VL - 21
IS - 4
M3 - Article
SP - 605
EP - 616
PB - Wiley-Blackwell
SN - 00192805
AB - An evaluation of the specificity of antigen binding receptors possessed by cells involved in cellular immune responses and by cells in the antibody synthesizing line was made in order to determine to what extent each cell type could distinguish between closely related mono-ε-DNP-oligo-L-lysines. The antigen binding receptors of cells involved in cellular immune responses were studied by the elicitation of delayed hypersensitivity reactions in vivo and by the stimulation of DNA synthesis by lymph node cells in vitro using 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. These experiments demonstrated that closely related compounds could be distinguished by this cell population. On the other hand, serum antibody from animals immunized with 1-ε-DNP-nona-L-lysine did not regularly distinguish between various mono-ε-DNP-oligo-L-lysines of differing immunogenicity or between 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. Serum antibody specificity is assumed to reflect the specificity of the receptors possessed by the precursors of antibody producing cells. Thus, it appears likely that the cells involved in cellular immune responses or functioning as 'helper' cells in the stimulation of antibody synthesis by other cells are capable of determining the immunogenicity of a compound. On the other hand, precursors of antibody producing cells, at least in primed animals and in the mono-ε-DNP-oligo-L-lysine response, do not appear to make distinctions between peptides of differing immunogenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - CELLULAR immunity
KW - IMMUNOGLOBULINS
KW - LIGAND binding (Biochemistry)
KW - IMMUNIZATION
KW - DINITROBENZENES
N1 - Accession Number: 13363557; Paul, W. E. 1 Stupp, Yehudit 2 Siskind, G. W. 3 Benacerraf, B. 4; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20014 and Division of Allergy and Immunology, Department of Medicine, Cornell Medical College, New York, U.S.A. 2: Department of Immunology, Hebrew Univ., Hadassah Medical School, Jerusalem, Israel 3: Career Scientist of the Health Research Council of the City of New york (Research Investigatorship I-593) 4: Department of Pathology, Harvard Medical School, Boston, Massachusetts, U.S.A.; Source Info: Oct71, Vol. 21 Issue 4, p605; Subject Term: IMMUNE response; Subject Term: CELLULAR immunity; Subject Term: IMMUNOGLOBULINS; Subject Term: LIGAND binding (Biochemistry); Subject Term: IMMUNIZATION; Subject Term: DINITROBENZENES; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paul, W. E.
AU - Stupp, Yehudit
AU - Siskind, G. W.
AU - Benacerraf, B.
T1 - Structural Control of Immunogenicity IV. RELATIVE SPECIFICITY OF ELICITATION OF CELLULAR IMMUNE RESPONSES AND OF LIGAND BINDING TO ANTI-HAPTEN ANTIBODY AFTER IMMUNIZATION WITH MONO-ε-DNP-NONA-L-LYSINE.
JO - Immunology
JF - Immunology
Y1 - 1971/10//
VL - 21
IS - 4
M3 - Article
SP - 605
EP - 616
SN - 00192805
AB - An evaluation of the specificity of antigen binding receptors possessed by cells involved in cellular immune responses and by cells in the antibody synthesizing line was made in order to determine to what extent each cell type could distinguish between closely related mono-ε-DNP-oligo-L-lysines. The antigen binding receptors of cells involved in cellular immune responses were studied by the elicitation of delayed hypersensitivity reactions in vivo and by the stimulation of DNA synthesis by lymph node cells in vitro using 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. These experiments demonstrated that closely related compounds could be distinguished by this cell population. On the other hand, serum antibody from animals immunized with 1-ε-DNP-nona-L-lysine did not regularly distinguish between various mono-ε-DNP-oligo-L-lysines of differing immunogenicity or between 1-ε-DNP-nona-L-lysine and 9-ε-DNP-nona-L-lysine. Serum antibody specificity is assumed to reflect the specificity of the receptors possessed by the precursors of antibody producing cells. Thus, it appears likely that the cells involved in cellular immune responses or functioning as 'helper' cells in the stimulation of antibody synthesis by other cells are capable of determining the immunogenicity of a compound. On the other hand, precursors of antibody producing cells, at least in primed animals and in the mono-ε-DNP-oligo-L-lysine response, do not appear to make distinctions between peptides of differing immunogenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - CELLULAR immunity
KW - IMMUNOGLOBULINS
KW - LIGAND binding (Biochemistry)
KW - IMMUNIZATION
KW - DINITROBENZENES
N1 - Accession Number: 13363557; Paul, W. E. 1; Stupp, Yehudit 2; Siskind, G. W. 3; Benacerraf, B. 4; Source Information: Oct71, Vol. 21 Issue 4, p605; Subject: IMMUNE response; Subject: CELLULAR immunity; Subject: IMMUNOGLOBULINS; Subject: LIGAND binding (Biochemistry); Subject: IMMUNIZATION; Subject: DINITROBENZENES; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1972-07387-001
AN - 1972-07387-001
AU - Symmes, Jean S.
T1 - Visual imagery in brain-injured children.
JF - Perceptual and Motor Skills
JO - Perceptual and Motor Skills
JA - Percept Mot Skills
Y1 - 1971/10//
VL - 33
IS - 2
SP - 507
EP - 514
CY - US
PB - Perceptual & Motor Skills
SN - 0031-5125
SN - 1558-688X
N1 - Accession Number: 1972-07387-001. PMID: 5124106 Other Journal Title: Perceptual & Motor Skills Research Exchange. Partial author list: First Author & Affiliation: Symmes, Jean S.; National Institutes of Health, Inst. of Child Health & Human Development, Bethesda, Md. Other Publishers: Sage Publications. Release Date: 19720401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain Damage; Imagery; Intelligence Quotient; Perceptual Aftereffect; Visual Perception. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 8. Issue Publication Date: Oct, 1971.
AB - Investigated the incidence of eidetic imagery and prolonged after-imagery in 37 5-14 yr. Old retardates. Incidence of eidetic imagery was 19%, significantly higher than normal samples, and all ss with eidetic imagery were classified as 'brain-injured' by common neurological diagnostic criteria. Ss with long, stable afterimages had a significantly higher mean iq than those with short afterimages, capacity for fixation and task learning being controlled. A possible explanation of the iq discrepancy is presented in terms of how a longer time to process visual input into short-term memory may be functional for children of low intelligence. (15 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - eidetic imagery & prolonged after-imagery
KW - IQ
KW - brain-injured 5-14 yr. olds
KW - 1971
KW - Brain Damage
KW - Imagery
KW - Intelligence Quotient
KW - Perceptual Aftereffect
KW - Visual Perception
KW - 1971
DO - 10.2466/pms.1971.33.2.507
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40831-015
AN - 2013-40831-015
AU - Shore, Milton F.
T1 - Whither child advocacy?
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1971/10//
VL - 41
IS - 5
SP - 798
EP - 798
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40831-015. PMID: 5118565 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Advocacy; Childhood Development; Family Relations; Mental Health. Minor Descriptor: Agency. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Page Count: 1. Issue Publication Date: Oct, 1971.
AB - The current interest in child advocacy was generated by the work of the Joint Commission on the Mental Health of Children. The Commission was eager to mobilize the country not only to improve existing services for children, but to generate community concern and involvement to establish new and better structures to facilitate healthy child development. The state and local child advocates would work closely with Federal agencies, perhaps as an Advocacy Council, to foster programs for children and their families. In order to make all levels ultimately accountable to the people, and to commit the country to a massive improvement in the children's area, perhaps a tradition should also be started requesting the President to report to Congress through a special message. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child advocacy
KW - mental health
KW - child development
KW - family dynamics
KW - Federal agencies
KW - 1971
KW - Advocacy
KW - Childhood Development
KW - Family Relations
KW - Mental Health
KW - Agency
KW - 1971
DO - 10.1111/j.1939-0025.1971.tb00744.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40831-022
AN - 2013-40831-022
AU - Katz, Martin M.
T1 - Problems of training in the application of a new system of classification for the psychosocial disorders.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1971/10//
VL - 41
IS - 5
SP - 841
EP - 843
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40831-022. PMID: 5118572 Partial author list: First Author & Affiliation: Katz, Martin M.; Clinical Research Branch, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Adjustment; Experimental Design; Mental Disorders; Psychosocial Development. Minor Descriptor: Behavior; Judgment; Taxonomies. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Oct, 1971.
AB - In this article, procedures reduce the influence of 'irrelevant' sources of variance and extend the sample of behavior upon which judgments can be based. The authors await the development of more objective methods for measuring these emotional and behavioral qualities, methods that will permit us to eventually dispense with the need for subjective judgment. Since it will be well into the future before that effort succeeds in providing sufficiently sensitive and feasible methods for routine application, it will help to turn to and to encourage the use of other observational sources and settings and more standardized examination procedures for the clinical interview itself. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial disorders
KW - behavioral qualities
KW - emotional qualities
KW - clinical interviews
KW - standardized examination
KW - 1971
KW - Emotional Adjustment
KW - Experimental Design
KW - Mental Disorders
KW - Psychosocial Development
KW - Behavior
KW - Judgment
KW - Taxonomies
KW - 1971
DO - 10.1111/j.1939-0025.1971.tb00751.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lowy, D. R.
AU - ROWE, W. P.
AU - TEICH, N.
AU - HARTLEY, J. W.
T1 - Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine.
JO - Science
JF - Science
Y1 - 1971/10/08/
VL - 174
IS - 4005
M3 - Article
SP - 155
EP - 156
SN - 00368075
AB - Cells of emnbryos of the high leukemnic inotise strain AKR can be grown in clultlure as virus-negative cell lines. However, these lines and clonal sublites uniform-1ly have the capacily to initiate synthesis of mnurine leukemia virus. Exposure of the cells to 5-iododeoxyltridine or 5-bromodcoxyuridine induced synthesis of viruts in as high as 0.1 to 0.5 percent of the cells; nmany of the cells were producing virus as soon as 3 days after initiation of treatment. Itndluclion of virtis by these drujgs is severcil orders of magnitude greater thanl that obtaimied with any other treatment tested. These stuidies indicat that the genomne of murine leuikemnia virus is present in an linexpressed form in all AKR cells and provide a potentially powered technique for activating lelukemnia virus genomes in other cell systemtis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002559; Lowy, D. R. 1; ROWE, W. P. 1; TEICH, N. 1; HARTLEY, J. W. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 10/ 8/1971, Vol. 174 Issue 4005, p155; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - AARONSON, STUART A.
AU - TODARO, GEORGE J.
AU - SCOLNICK, EDWARD M.
T1 - Induction of Murine C-Type Viruses from Clonal Lines of Virus-Free BALB/3T3 Cells.
JO - Science
JF - Science
Y1 - 1971/10/08/
VL - 174
IS - 4005
M3 - Article
SP - 157
EP - 159
SN - 00368075
AB - Each clone of BALBIc mouse embryo cells that has been tested can be induced to form C-type virus. The individual cells therefore contain a complete copy of the genetic information for making the murine RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002560; AARONSON, STUART A. 1; TODARO, GEORGE J. 1; SCOLNICK, EDWARD M. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/ 8/1971, Vol. 174 Issue 4005, p157; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BROWN, JOEL E.
AU - MULLER, KENNETH J.
AU - MURRAY, GEORGE
T1 - Reversal Potential for an Electrophysiological Event Generated by Conductance Changes: Mathematical Analysis.
JO - Science
JF - Science
Y1 - 1971/10/15/
VL - 174
IS - 4006
M3 - Article
SP - 318
EP - 318
SN - 00368075
N1 - Accession Number: 87634311; BROWN, JOEL E. 1; MULLER, KENNETH J. 1; MURRAY, GEORGE 2; Affiliations: 1: Department of Biology and Research Laboratory of Technology, Massachusetts Institute of Technology, Cambridge 02139; 2: Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/15/1971, Vol. 174 Issue 4006, p318; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Wyatt, R. J.;
AU - Fram, D. H.;
AU - Buchbinder, R.;
AU - Snyder, F.;
T1 - Treatment of intractable narcolepsy with a monoamine oxidase inhibitor
CT - Treatment of intractable narcolepsy with a monoamine oxidase inhibitor
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/10/28/
VL - 285
IS - Oct 28
SP - 987
EP - 991
SN - 00284793
AD - National Institute of Mental Health, Building 10, Room 3N262, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 9-1658; Language: English; Chemical Name: Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine; References: 20; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Seven patients with intractable narcolepsy were treated with phenelzine. Striking reductions in the amount of cataplectic attacks, sleep paralysis and hypnagogic hallucinations were noted. In addition, daytime sleeping and hypersomnia were diminished, but side effects (hypotension, edema, impaired sexual function) were bothersome. Phenelzine almost completely suppressed rapid eye movement (REM) sleep and remained effective for periods of more than a year. Although dreams were frequently reported before drug treatment, no dreams were reported when REM sleep was completely absent. No adverse psychologic effects were noted during the period of total REM suppression.
KW - Phenelzine--narcolepsy-;
KW - Antidepressants--phenelzine--narcolepsy, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Howe, Warren P.
AU - Cargille, Charles M.
AU - Dodge, Lowell
T1 - Proposal for an Auto Safety Directory.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/11//
VL - 61
IS - 11
M3 - Letter
SP - 2163
EP - 2163
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented about the proposal for a motor vehicle safety directory.
KW - Letters to the editor
KW - Directories
N1 - Accession Number: 24851708; Howe, Warren P. 1; Cargille, Charles M. 2; Dodge, Lowell 3; Affiliations: 1: National Association of Counties Research Foundation, D.C.; 2: National Institute of Child Health and Human Development, Md.; 3: Center for Auto Safety Washington, D.C.; Issue Info: Nov1971, Vol. 61 Issue 11, p2163; Subject Term: Letters to the editor; Subject Term: Directories; NAICS/Industry Codes: 511140 Directory and Mailing List Publishers; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Milne, G. W. A.;
AU - Fales, H. M.;
AU - Axenrod, T.;
T1 - Identification of dangerous drugs by isobutane chemical ionization mass spectrometry
CT - Identification of dangerous drugs by isobutane chemical ionization mass spectrometry
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1971/11/01/
VL - 43
IS - Nov
SP - 1815
EP - 1820
AD - Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-0630; Language: English; References: 17; Journal Coden: ANCHAM; Section Heading: Drug Analysis
N2 - The isobutane chemical ionization mass spectra of 48 commonly used drugs have been measured. The majority of these give only an MH\SU/+ \BS/ion which can be used to identify the compound. In a few cases, the fragmentation of the MH\SU/+ \BS/ion is observed and can be rationalized in terms of simple acid-catalyzed reactions. Examples of the use of this technique in the identification of drugs taken in overdose quantities by patients admitted to a hospital are provided. Drugs analyzed included analgesics, barbiturates and tranquilizers.
KW - Spectrometry--mass--isobutane chemical ionization, in identification of drugs;
KW - Barbiturates--spectrometry--mass, isobutane chemical ionization;
KW - Analgesics and antipyretics--spectrometry--mass, isobutane chemical ionization;
KW - Tranquilizers--spectrometry--mass, isobutane chemical ionization;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T., Jr.;
AU - Carbone, P. P.;
T1 - Chemotherapeutic implications of staging in Hodgkin's disease
CT - Chemotherapeutic implications of staging in Hodgkin's disease
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1971/11/01/
VL - 31
IS - Nov
SP - 1838
EP - 1844
SN - 00085472
AD - Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1513; Language: English; Chemical Name: Mechlorethamine--51-75-2 Chlorambucil--305-03-3 Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Procarbazine--671-16-9 Prednisone--53-03-2; References: 29; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Jimmie L. Hall
N2 - This article discusses the use of mechlorethamine, chlorambucil, cyclophosphamide, vincristine, procarbazine, and prednisone, or combinations of these, in the treatment of Hodgkin's disease.
KW - Mechlorethamine--Hodgkin's disease-;
KW - Chlorambucil--Hodgkin's disease-;
KW - Cyclophosphamide--Hodgkin's disease-;
KW - Vincristine--Hodgkin's disease-;
KW - Procarbazine--Hodgkin's disease-;
KW - Prednisone--Hodgkin's disease-;
KW - Antineoplastic agents--alone or in combination--Hodgkin's disease, therapy, discussion;
KW - Combined therapy--antineoplastic agents--Hodgkin's disease, discussion;
KW - Antineoplastic agents--Hodgkin's disease--therapy, alone or in combination, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Feldmann, Richard J
AU - Heller, Stephen R
AU - Shapiro, Kenneth P
T1 - An experimental computerized cbac search project
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1971/11//
VL - 11
IS - 4
M3 - Article
SP - 248
EP - 251
SN - 00219576
AB - A literature search system for cbac is described. Both sdi and retrospective searching techniques are available to the user. The system relies heavily on searching keywords from the cbac text rather than the text itself and employs batch/tape and time-sharing disk hardware.
N1 - Accession Number: ISTA0700642; Feldmann, Richard J 1; Heller, Stephen R; Shapiro, Kenneth P; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: November 1971, Vol. 11 Issue 4, p248; Note: Update Code: 0700; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Symmes, David
AU - Eisengart, Marvin A.
T1 - EVOKED RESPONSE CORRELATES OF MEANINGFUL VISUAL STIMULI IN CHILDREN.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1971/11//
VL - 8
IS - 6
M3 - Article
SP - 769
EP - 778
SN - 00485772
AB - Photographic slides of familiar objects or cartoons were tachistoscopically presented to a group of 79 normal children (age 5-11 years) in a study of the evoked response correlates of meaningful visual stimuli. Control stimuli consisted of blank slides or defocused cartoons matched for brightness. A warning flash preceded the slides by 1 sec. EEG and eye movement potentials were recorded on line with a 9.5 sec time constant and averaged off-line. The principal finding was a vertex negative slow potential peaking about 500 msec after slide presentation which correlated with reports of interest in and recall of both objects and cartoons. Responses in the occipital region changed less consistently with pictorial material, and were the same to the warning flash whether it preceded control or test stimuli. The vertex negative response appears to be a corollary of perceptual integration of meaningful stimuli. Among alternative explanations nonspecific differences in arousal level and/or expectancy appear to be unlikely on the basis of our data. A primary role of edge contrast in generating these late negative responses would not be predicted on the basis of published evidence, but our attempt to control for this alternative yielded equivocal results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VISUAL evoked response
KW - ELECTROENCEPHALOGRAPHY
KW - CHILDREN
KW - PSYCHOPHYSIOLOGY
N1 - Accession Number: 11056523; Symmes, David 1 Eisengart, Marvin A. 1; Affiliation: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: Nov1971, Vol. 8 Issue 6, p769; Subject Term: VISUAL evoked response; Subject Term: ELECTROENCEPHALOGRAPHY; Subject Term: CHILDREN; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ALLEVA, JOHN J.
AU - ALLEVA, FREDERIC R.
AU - FRY JR., BERT E.
AU - EANES, EDWARD D.
T1 - Calcium Carbonate Concretions: Cyclic Occurrence in the Hamster Vagina.
JO - Science
JF - Science
Y1 - 1971/11/05/
VL - 174
IS - 4009
M3 - Article
SP - 600
EP - 603
SN - 00368075
AB - Three crystalline forms of calcium carbonate were identified in washings of the hamster vagina. Spherical concretions of vaterite and hexagonal concretions of calcite predominate on days 3 and 4 of the 4-day estrous cycle. Dumbbell-like concretions of aragonite predominate during pregnancy and pseudopregnancy. Each polymorph is associated with an acid-insoluble matrix. Concretions disappear after ovariectomy and reappear during daily injections of estrogen and progesterone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002637; ALLEVA, JOHN J. 1; ALLEVA, FREDERIC R. 1; FRY JR., BERT E. 1; EANES, EDWARD D. 2; Affiliations: 1: Food and Drug Administration, Departmenit of Health, Education, and Welfare, Washington, D.C. 20204; 2: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/ 5/1971, Vol. 174 Issue 4009, p600; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WILLIMS, R. B.
AU - EICHELMAN, B.
T1 - Social Setting: Influence on the Physiological Response to Electric Shock in the Rat.
JO - Science
JF - Science
Y1 - 1971/11/05/
VL - 174
IS - 4009
M3 - Article
SP - 613
EP - 614
SN - 00368075
AB - A significant fall in tail blood pressure occurs in paired rats after shock-induced aggression. Pressure returns to baseline levels within 4 hours after fighting. Conversely, single rats subjected to jump threshold measurements or to shocks identical to those used in the aggression paradigm show significant elevations in tail blood pressure. The size of the pressure increase in rats shocked alone appears dependent on the intensity of the shocks, while the pressure fall in rats shocked in pairs occurs over a broad range of shock intensities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002642; WILLIMS, R. B. 1; EICHELMAN, B. 1; Affiliations: 1: Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 11/ 5/1971, Vol. 174 Issue 4009, p613; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dunn, T. B.;
T1 - Carcinogenic action of estrogens
CT - Carcinogenic action of estrogens
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/11/11/
VL - 285
IS - Nov 11
SP - 1147
SN - 00284793
AD - National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 9-1205; Language: English; Trade Name: Enovid; Generic Name: Norethynodrel; Chemical Name: Diethylstilbestrol--56-53-1 Norethynodrel--68-23-5 Mestranol--72-33-3; Therapeutic Class: (68:12); AHFS Class: Contraceptives, oral norethynodrel, combination, mestranol (68:16); AHFS Class: Estrogens diethylstilbestrol; Publication Type: Correspondence; Journal Coden: NEJMAG; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Results obtained by injecting diethylstilbestrol or norethynodrel with mestranol (Enovid) into newborn mice are presented. The animal experiments suggest that if immature individuals of either human or animal species are exposed to an excess of estrogen, cancer may develop.
KW - Diethylstilbestrol--toxicity-;
KW - Norethynodrel--combination, mestranol-;
KW - Mestranol--combination, norethynodrel-;
KW - Contraceptives, oral--norethynodrel, combination, mestranol--injections, possible carcinogenic activity, in mice;
KW - Estrogens--diethylstilbestrol--injections, possible carcinogenic activity, in mice;
KW - Toxicity--diethylstilbestrol--injections, studies, possible carcinogenic activity, in mice;
KW - Toxicity--norethynodrel, combination, mestranol--injections, studies, possible carcinogenic activity, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BURKE, R. E.
AU - LEVINE, D. N.
AU - ZAJAC III, F. E.
AU - TSAIRIS, P.
AU - ENGEL, W. K.
T1 - Mammalian Motor Units: Physiological-Histochemical Correlation in Three Types in Cat Gastrocnemius.
JO - Science
JF - Science
Y1 - 1971/11/12/
VL - 174
IS - 4010
M3 - Article
SP - 709
EP - 712
SN - 00368075
AB - The correlation among a variety of physiological properties and the histochemical characteristics of muscle fibers belonging to single motor units in a mixed mammalian muscle is directly demonstrated. The population of motor units making up the cat gastrocnemius was classified into three nonoverlapping groups on the basis of a combination of physiological parameters. The muscle fibers belonging to motor units of each physiological type exhibited a distinctive histochemical profile, such that the three basic histochemical "fiber types" exactly matched the three physiologically defined groups. Within each individual motor unit, the muscle fibers were histochemically uniform. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002676; BURKE, R. E. 1; LEVINE, D. N. 1; ZAJAC III, F. E. 1; TSAIRIS, P. 2; ENGEL, W. K. 2; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: Medical Neurology Branch, National Institute of Neurological Diseases and Stroke; Issue Info: 11/12/1971, Vol. 174 Issue 4010, p709; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GLENNER, G. G.
AU - EIN, D.
AU - EANES, E. D.
AU - BLADEN, H. A.
AU - TERRY, W.
AU - PAGE, D. L.
T1 - Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro.
JO - Science
JF - Science
Y1 - 1971/11/12/
VL - 174
IS - 4010
M3 - Article
SP - 712
EP - 714
SN - 00368075
AB - "Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, β-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002677; GLENNER, G. G. 1; EIN, D. 1; EANES, E. D. 1; BLADEN, H. A. 1; TERRY, W. 1; PAGE, D. L. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/12/1971, Vol. 174 Issue 4010, p712; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Adamson, R. H.;
T1 - Antileukemic activity of hycanthone
CT - Antileukemic activity of hycanthone
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1971/11/27/
VL - 2
IS - Nov 27
SP - 1206
SN - 00237507
AD - Section of Pharmacology and Experimental Therapeutics, Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-1508; Language: English; Chemical Name: Hycanthone--3105-97-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents hycanthone; References: 7; Publication Type: Letters to the Editor; Journal Coden: LANCAO; Section Heading: Preliminary Drug Testing; Abstract Author: Douglas L. Thompson
N2 - Hycanthone methanesulfonate showed cytotoxic activity in vitro and in vivo against leukemia L1210 and P388. Since this drug has shown a low toxicity in the therapy of schistosomiasis in patients, it is suggested that this compound should be evaluated for activity against leukemia in man.
KW - Hycanthone--methanesulfonate-;
KW - Antineoplastic agents--hycanthone--methanesulfonate, in vitro and in vivo, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Bluming, A. Z.
AU - Ziegler, J. L.
AU - Fass, L.
AU - Herberman, R. B.
T1 - DELAYED CUTANEOUS SENSITIVITY REACTIONS TO AUTOLOGOUS BURKITT LYMPHOMA PROTEIN EXTRACTS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/12//
VL - 9
IS - 6
M3 - Article
SP - 713
EP - 719
PB - Wiley-Blackwell
SN - 00099104
AB - Positive delayed cutaneous sensitivity reactions to protein extracts of autologous Burkitt lymphoma cells were observed in fifteen of thirty patients tested in clinical systemic remission and in only one of sixteen patients tested with active extradural disease. Positive responding patients who eventually relapsed had significantly longer remission durations than did their negative responding counterparts. Seven patients with positive reactions were negative when retested in relapse. Positive reactions were not observed at extract protein concentrations of 01 mg/ml and were maximally evident at 1 mg/ml. Negative skin tests could not be attributed to generalized anergy because of the simultaneous observation of positive reactions to common antigens in over half the negative responders. Cutaneous reactivity to autologous tumour extract may serve as a sensitive test for extradural disease activity, and, because of its association with remission duration, suggests a role for the specifically sensitized lymphocyte in tumour regression and prognosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells -- Tumors
KW - LYMPHOMAS
KW - DISEASES
KW - PROGNOSIS
KW - ANTIGENS
KW - PATIENTS
N1 - Accession Number: 14541768; Bluming, A. Z. 1,2 Ziegler, J. L. 1,2 Fass, L. 1,2 Herberman, R. B. 1,2; Affiliation: 1: Lymphoma Treatmen Centre, Department of Surgery, Makerere University College Medical School, Kampala, Uganda 2: Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S. A.; Source Info: Dec71, Vol. 9 Issue 6, p713; Subject Term: B cells -- Tumors; Subject Term: LYMPHOMAS; Subject Term: DISEASES; Subject Term: PROGNOSIS; Subject Term: ANTIGENS; Subject Term: PATIENTS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirkpatrick, C. H.
AU - Rich, R. R.
AU - Graw Jr, R. G.
AU - Smith, T. K.
AU - Irad Mickenberg
AU - Rogentine, G. N.
T1 - TREATMENT OF CHRONIC MUCOCUTANEOUS MONILIASIS BY IMMUNOLOGIC RECONSTITUTION.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/12//
VL - 9
IS - 6
M3 - Article
SP - 733
EP - 748
PB - Wiley-Blackwell
SN - 00099104
AB - The immunological defect in a patient with chronic mucocutaneous moniliasis was characterized. While his Candida skin test was negative, exposure of his lymphocytes to candida extracts in vitro produced an increase in thymidine incorporation. Supernatants from cultures of antigen-stimulated lymphocytes did not contain macrophage migration-inhibition factor (MIF) activity. Restoration of the immune system with transfusions of immuno-competent allogeneic lymphocytes was accompanied by conversion of the Candida skin test to positive, and MW production by his lymphocytes. During the period that his immune system remained intact, there was marked clearing of the moniliasis. Eight months following the transfusions, the moniliasis recurred and when restudied, the patient again had negative skin tests and insignificant MIF production. These observations demonstrate the importance of mediators in the expression of delayed hypersensitivity and provide evidence of a role of cellular immunity in resistance to certain chronic fungal infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANDIDIASIS
KW - MUCOUS membrane -- Diseases
KW - LYMPHOCYTES
KW - THYMIDINE
KW - MYCOSES
KW - CANDIDA
N1 - Accession Number: 14541825; Kirkpatrick, C. H. 1,2 Rich, R. R. 1,2 Graw Jr, R. G. 1,2 Smith, T. K. 1,2 Irad Mickenberg 1,2 Rogentine, G. N. 1,2; Affiliation: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U. S. A. 2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, U. S. A.; Source Info: Dec71, Vol. 9 Issue 6, p733; Subject Term: CANDIDIASIS; Subject Term: MUCOUS membrane -- Diseases; Subject Term: LYMPHOCYTES; Subject Term: THYMIDINE; Subject Term: MYCOSES; Subject Term: CANDIDA; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ellman, L.
AU - Inman, J.
AU - Green, Ira
T1 - STRAIN DIFFERENCE IN THE IMMUNE RESPONSE TO HYDRALAZINE IN INBRED GUINEA-PIGS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1971/12//
VL - 9
IS - 6
M3 - Article
SP - 927
EP - 937
PB - Wiley-Blackwell
SN - 00099104
AB - Guinea-pigs were immunized with hydralazine in Freund's complete adjuvant. A marked strain difference in the immune response involving both anti-hydralazine antibody and delayed hypersensitivity to hydralazine was observed in different strains of guinea-pigs: Hartley guinea-pigs and inbred strain 13 guinea-pigs were able to mount a vigorous immune response to the drug while inbred strain 2 guinea-pigs appeared to be 'low or non-responders'. This difference could not be explained in terms of metabolism of the drug in that no differences in acetylation were observed. Breeding studies suggest that immune responsiveness to hydralazine is inherited in an autosomal dominant manner. The immune response to hydralazine may be controlled by a 'specific immune response gene' which appears not to be linked to the major strain 13 histocompatibility gene. Anti-nuclear and anti-DNA antibodies could not be demonstrated at a time when the animals manifested a strong immune response to hydralazine. Thus, the development of auto-immune phenomena does not appear to be related to the development of an immune response to the drug in short term immunization. Hydralazine-protein conjugates were synthesized, radio-iodinated and used in a Farr technique for the measurement of anti-hydralazine antibody. These techniques for the assay of anti-hydralazine antibodies may be useful in clinical investigations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDRALAZINE
KW - METABOLISM
KW - GUINEA pigs
KW - CARDIOVASCULAR agents
KW - IMMUNE response
KW - GENES
N1 - Accession Number: 14542409; Ellman, L. 1 Inman, J. 1 Green, Ira 1; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Dec71, Vol. 9 Issue 6, p927; Subject Term: HYDRALAZINE; Subject Term: METABOLISM; Subject Term: GUINEA pigs; Subject Term: CARDIOVASCULAR agents; Subject Term: IMMUNE response; Subject Term: GENES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Schrogie, J. J.;
T1 - Facilities available for surveillance of the side effects of fertility regulating agents in the United States
CT - Facilities available for surveillance of the side effects of fertility regulating agents in the United States
JO - Contraception (USA)
JF - Contraception (USA)
Y1 - 1971/12/01/
VL - 4
IS - Dec
SP - 401
EP - 409
SN - 00107824
AD - Fertility Regulating Methods Evaluation Branch Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1 - Accession Number: 10-1920; Language: English; References: 12; Journal Coden: CCPTAY; Section Heading: Information Processing and Literature; Sociology, Economics and Ethics
N2 - A number of techniques utilizing currently available facilities may be employed to assess the extent of use and side effects of contraceptive agents. Interpretation of vital statistics and survey information describes trends in mortality from selected causes and choice of contraceptive agent. The use of adverse drug reaction surveillance and multiphasic screening programs may identify more specific relationships between drugs, devices and diseases. Such findings may stimulate the development of in depth clinical evaluations or epidemiological studies of specific subjects such as thromboembolism and cancer. A number of representative studies are identified which may yield information not only describing elements of risk but also of demographic value. Full and coordinated use of these opportunities for information gathering will generate more accurate assessments of contraceptive status in large populations and form a more adequate baseline for future evaluations.
KW - Drug information--contraceptives, oral--sources, for surveillance of side effects, in U.S.;
KW - Toxicity--contraceptives, oral--side effects, sources, available for surveillance, in U.S.;
KW - Contraceptives, oral--toxicity--side effects, information, sources, available for surveillance, in U.S.;
KW - Statistics--contraceptives, oral--side effects, sources of available information;
KW - Drugs, adverse reactions--contraceptives, oral--information, sources available for surveillance, in U.S.;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
T1 - THE ATTRIBUTION BY OPIATE ADDICTS OF CHARACTERISTICS TO ADDICT SUBGROUPS AND TO SELF.
AU - Monroe, Jack J.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1971/12//
VL - 85
IS - 2
SP - 239
EP - 249
SN - 00224545
N1 - Accession Number: 16471462; Author: Monroe, Jack J.: 1 ; Author Affiliation: 1 National Institute of Mental Health, Lexington, Kentucky.; No. of Pages: 11; Language: English; Publication Type: Article; Update Code: 20050323
N2 - The purpose of this paper was to demonstrate the applicability of perceived similarity and social favorability scales to the assessment of reference group valences in opiate addicts. Parallel sets of questionnaire items were constructed to elicit favorable and unfavorable self-presentations and group assessments on three status dimensions where in each dimension one pole represented a specified membership group presumed to be a positive reference group, while the other pole symbolized a contrasting, and presumably negative reference group. An item by item scoring of congruent responses to pairs cif items describing self and designated subgroups yielded measures of addict identification or psychological closeness of addicts with reference groups. Configurally scored scales were not superior to single response scales in differentiating the valence levels of reference groups. Greater favorability was ascribed to membership groups. Subjects tended to attribute unfavorable qualities (and in some cases tended to neutralize their responses) to nonmembership groups. ABSTRACT FROM AUTHOR
KW - *SOCIAL psychology
KW - REFERENCE groups
KW - SOCIAL groups
KW - SOCIAL interaction
KW - MEMBERSHIP
KW - BEHAVIOR
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Kiefer, James E.
AU - Weiss, George H.
T1 - A Truncated Test for Choosing the Better of Two Binomial Populations.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1971/12//
VL - 66
IS - 336
M3 - Article
SP - 867
SN - 01621459
AB - It is shown that a test suggested by Bechhofer, Kiefer, and Sobel [1], for selecting the better of two binomial populations, can be formulated and solved when a maximum number of tests is specified. If is assumed that the probability of correctly selecting the better population is specified to be better than P[sup *] when the difference in success probabilities exceeds a specified change[sup *]. The populations are sampled equally and it is assumed that the trial ends either when the difference in the number of successes exceeds a calculated value of s, or when N tests have been made, whichever is sooner. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - STATISTICAL hypothesis testing
KW - SAMPLING (Statistics)
KW - EXAMINATIONS
KW - CORRELATION (Statistics)
KW - STATISTICS
KW - BINOMIAL distribution
KW - BINOMIAL theorem
N1 - Accession Number: 4610203; Kiefer, James E. 1; Weiss, George H. 2; Affiliations: 1: Research Mathematician, Physical Sciences Laboratory, Division of Computer Research & Technology, National Institutes of Health, Bethesda, Md. 20014.; 2: Chief, Physical Sciences Laboratory, Division of Computer Research & Technology, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Dec71, Vol. 66 Issue 336, p867; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: EXAMINATIONS; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Lemberger, L.;
AU - Axelrod, J.;
AU - Kopin, I. J.;
T1 - Metabolism and disposition of \D/\SU/1\BS/-tetrahydrocannabinol in man
CT - Metabolism and disposition of \D/\SU/1\BS/-tetrahydrocannabinol in man
JO - Pharmacol. Rev.
JF - Pharmacol. Rev.
Y1 - 1971/12/01/
VL - 23
IS - Dec
SP - 371
EP - 379
AD - National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1157; Language: English; References: 37; Journal Coden: PAREAQ; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Ronald E. Nagata, Jr.
N2 - Radiotracer studies with intravenous \D/\SU/1\BS/-tetrahydrocannabinol (I) showed evidence of I metabolites in the plasma within 10 minutes and of persistence over 3 days. The I is metabolized to more polar products. About 40% of the radioactive forms appear in the feces over a 7-day period and about 30% in the urine of chronic marihuana users. The nonusers excrete 22% of the drug and its metabolites in the urine.
KW - Tetrahydrocannabinol--metabolism-;
KW - Metabolism--tetrahydrocannabinol--and disposition, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BAKER, CARL G.
T1 - Cancer Conquest Program.
JO - Science
JF - Science
Y1 - 1971/12/03/
VL - 174
IS - 4013
M3 - Article
SP - 980
EP - 981
SN - 00368075
N1 - Accession Number: 85116582; BAKER, CARL G. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 3/1971, Vol. 174 Issue 4013, p980; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PETRICCIANI, JOHN C.
AU - HoPPS, HOPE E.
AU - LORENZ, DOUGLAS E.
T1 - Subhuman Primate Diploid Cells: Possible Substrates for Production of Virus Vaccines.
JO - Science
JF - Science
Y1 - 1971/12/03/
VL - 174
IS - 4013
M3 - Article
SP - 1025
EP - 1027
SN - 00368075
AB - Results of a program for development of new cell lines suggest that it it possible to establish cell lines from both rhesus and African green monkeys which are comparable to diploid lines of human origin, and that these inonkey lines should be candidates for use in the production of virus vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116607; PETRICCIANI, JOHN C. 1; HoPPS, HOPE E. 1; LORENZ, DOUGLAS E. 1; Affiliations: 1: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 3/1971, Vol. 174 Issue 4013, p1025; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Weisburger, E. K.;
T1 - Testing of new compounds for long-term toxicity
CT - Testing of new compounds for long-term toxicity
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1971/12/09/
VL - 22
IS - Dec 9
SP - 825
EP - 838
SN - 00379832
AD - Experimental Pathology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1387; Language: English; Trade Name: Tests; Generic Name: Toxicity; References: 43; Publication Type: Review; Journal Coden: JSCCA5; Section Heading: Methodology
N2 - A survey was made of methods generally employed in testing compounds for long-term toxicity or carcinogenicity. Although the long-term testing of new compounds for chronic toxicity may superficially appear to be a straightforward matter, many factors can influence the outcome of such studies. These include the species and strain of test animal, age at start of the tests, sex, vehicle and route of administration, diet, and other variables. Some materials which are used in cosmetic formulations have the capacity to inhibit or to enhance the response of animals to known carcinogens. Awareness of all these influences is neccessary in designing meaningful long-term test for toxicity.
KW - Toxicity--tests--chronic, discussion, in animals;
KW - Methodology--toxicity--chronic, tests, in animals;
KW - Carcinogens--tests--methods, chronic toxicity, in animals;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MANN, DEAN L.
AU - ROGENTINE, G. NICHOLAS
AU - HALTERMAN, ROGER
AU - LEVENTHAL, BRIGID
T1 - Detection of an Antigen Associated with Acute Leukemia.
JO - Science
JF - Science
Y1 - 1971/12/10/
VL - 174
IS - 4014
M3 - Article
SP - 1136
EP - 1137
SN - 00368075
AB - Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87599952; MANN, DEAN L. 1; ROGENTINE, G. NICHOLAS 1; HALTERMAN, ROGER 1; LEVENTHAL, BRIGID 1; Affiliations: 1: Immunology Branch and Leukemia Service, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/10/1971, Vol. 174 Issue 4014, p1136; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CROZIER, RUTH
T1 - Regulation of Mammalian Reproduction.
JO - Science
JF - Science
Y1 - 1971/12/10/
VL - 174
IS - 4014
M3 - Article
SP - 1157
EP - 1159
SN - 00368075
N1 - Accession Number: 87599961; CROZIER, RUTH 1; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/10/1971, Vol. 174 Issue 4014, p1157; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GODFAIND, J. M.
AU - PUMAIN, R.
AU - SIGGINS, G. R.
AU - HOFFER, B. J.
AU - BLOOM, F. E.
T1 - Cyclic Adenosine Monophosphate and Norepinephrine: Effect on Purkinje Cells in Rat Cerebellar Cortex.
JO - Science
JF - Science
Y1 - 1971/12/17/
VL - 174
IS - 4015
M3 - Article
SP - 1257
EP - 1259
SN - 00368075
N1 - Accession Number: 85116658; GODFAIND, J. M. 1; PUMAIN, R. 1; SIGGINS, G. R. 2; HOFFER, B. J. 2; BLOOM, F. E. 2; Affiliations: 1: Department of Research in Anaesthesia, McGill University, Montreal, Quebec, Canada; 2: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 12/17/1971, Vol. 174 Issue 4015, p1257; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stetten Jr., DeWitt
T1 - Projected Changes in Medical School Curriculum.
JO - Science
JF - Science
Y1 - 1971/12/24/
VL - 174
IS - 4016
M3 - Article
SP - 1303
EP - 1306
SN - 00368075
N1 - Accession Number: 85159852; Stetten Jr., DeWitt 1; Affiliations: 1: Director, National Institute of General Medical Sciences, National Institutes, Health, Bethesda, Maryland 20014; Issue Info: 12/24/1971, Vol. 174 Issue 4016, p1303; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSI41LBOUM, RICHARD M.
AU - THOA, NGUYEN B.
AU - JOHNSON, DAVID G.
AU - KOPIN, IRWIN J.
AU - AXELROD, JULIUS
T1 - Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves.
JO - Science
JF - Science
Y1 - 1971/12/24/
VL - 174
IS - 4016
M3 - Article
SP - 1349
EP - 1351
SN - 00368075
AB - Dopamine-β-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. This enzyme is released with norepinephrine when the nerves to the guinea pig vas deferens are stimulated in vitro, and the amount of enzyme discharged increases as the length of stimulation periods increases. The amount of DBH released is proportional to the amount of norepinephrine released, and the ratio of norepinephrine to DBH discharged into the incubation medium is similar to that in the soluble portion of the contents of the synaptic vesicflers om the vas deferens. These data are compatible with the release of the neurotransmitter norepinephrine and DBH from symnpathetic nerves by a process of exocytosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159876; WEINSI41LBOUM, RICHARD M. 1; THOA, NGUYEN B. 1; JOHNSON, DAVID G. 1; KOPIN, IRWIN J. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/24/1971, Vol. 174 Issue 4016, p1349; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
T1 - Psychiatric side effects of levodopa in man
CT - Psychiatric side effects of levodopa in man
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/12/27/
VL - 218
IS - Dec 27
SP - 1915
EP - 1920
AD - Section on Psychiatry, Laboratory of Clinical Science, Building 10, Room 45-239, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-1809; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 65; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - The major psychiatric side effects reported in 908 parkinsonian patients treated with levodopa were confusion, delirium, depression, overactivity, psychosis, delusions, paranoia, hypomania and hypersexual behavior. Since mental side effects of levodopa therapy varied from individual to individual, it is clear that levodopa does not uniformly produce a specific set of mental changes.
KW - Levodopa--toxicity-;
KW - Toxicity--levodopa--side effects, psychiatric, in patients;
KW - Antiparkinson agents--levodopa--toxicity, side effects, psychiatric, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fauci, A. S.;
AU - Wolff, S. M.;
AU - Johnson, J. S.;
T1 - Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis
CT - Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/12/30/
VL - 285
IS - Dec 30
SP - 1493
EP - 1496
SN - 00284793
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, 11 South, Room 242, Bethesda, Maryland 20014
N1 - Accession Number: 9-1637; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents cyclophosphamide; References: 31; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Nine patients with Wegener's granulomatosis were studied before and after treatment with cyclophosphamide alone, in order to determine any immunologic abnormalities associated with the disease, to observe the effect of cyclophosphamide on the clinical course, as well as on the immune response in man, and to observe any correlation between clinical response and immunosuppression. The doses of cyclophosphamide varied from 50 to 125 mg./day, and the duration of therapy varied from one to 39 months in the patients studied. This study showed that patients with generalized Wegener's granulomatosis treated with cyclophosphamide alone display suppressed humoral antibody and cellular (delayed skin reactivity) responses to an antigen with which they have had no prior immunologic experience.
KW - Cyclophosphamide--Wegener's granulomatosis-;
KW - Immunosuppressive agents--cyclophosphamide--Wegener's granulomatosis, therapy, in patients, effect on immune response;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Davidson, M.;
AU - Feinleib, M.;
T1 - Carbon disulfide poisoning: a review
CT - Carbon disulfide poisoning: a review
JO - Am. Heart J.
JF - Am. Heart J.
Y1 - 1972/01/01/
VL - 83
IS - Jan
SP - 100
EP - 114
AD - Field Epidemiology Research Section, Clinical Applications Program, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2093; Language: English; Chemical Name: Carbon disulfide--75-15-0; References: 63; Publication Type: Review; Journal Coden: AHJOA2; Section Heading: Toxicity; Abstract Author: David D. Edwards
N2 - A review of carbon disulfide (CS\IF/2\BS/), as a possible industrial hazard, is presented.
KW - Carbon disulfide--toxicity, environmental-;
KW - Toxicity, environmental--carbon disulfide--review, possible industrial hazard;
KW - Poisoning--carbon disulfide--effects, acute and chronic toxicity, in man, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Law, N. C.;
AU - Fales, H. M.;
AU - Milne, G. W. A.;
T1 - Identification of drugs taken in overdose cases
CT - Identification of drugs taken in overdose cases
JO - Clin. Toxicol.
JF - Clin. Toxicol.
Y1 - 1972/01/01/
VL - 5
IS - Jan
SP - 17
EP - 21
AD - Suburban Hospital and Laboratory of Chemistry, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-0327; Language: English; References: 2; Journal Coden: CTOXAO; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - Mass spectrometry was used to identify drug products in gastric contents, serum, urine, and gastric lavage fluids. Gastric contents were the most promising source of large quantities of unchanged drugs. If these were not available, the first gastric lavage fluids proved most useful. Drug metabolites in the urine and serum can produce confusing data; however, positive drug identification can be made.
KW - Spectrometry, mass--toxicology--drugs, identification in overdose cases;
KW - Poisoning--drugs--identification, mass spectrometry;
KW - Toxicity--drugs--overdosage, identification of drugs by mass spectrometry;
KW - Metabolism--drugs--body distribution, identification, in overdose cases, mass spectrometry;
KW - Drugs, body distribution--poisoning--identification, in overdose cases, mass spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Shrager, Richard I.
AU - Timlake, W. P.
T1 - Quadratic Programming for Nonlinear Regression.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1972/01//
VL - 15
IS - 1
M3 - Article
SP - 41
EP - 46
SN - 00010782
AB - A quadratic programming algorithm is described for use with the magnified diagonal method of nonlinear regression with linear constraints. The regression method is published in JACM, July 1970. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUADRATIC programming
KW - ALGORITHMS
KW - REGRESSION analysis
KW - NONLINEAR programming
KW - MATHEMATICAL statistics
KW - MATHEMATICAL programming
KW - constraints
KW - inequality
KW - iteration
KW - least squares
KW - nonlinear equations
KW - nonlinear programming
KW - nonlinear regression
KW - quadratic programming
N1 - Accession Number: 5221620; Shrager, Richard I. 1 Timlake, W. P.; Affiliation: 1: Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, MA 20014.; Source Info: Jan1972, Vol. 15 Issue 1, p41; Subject Term: QUADRATIC programming; Subject Term: ALGORITHMS; Subject Term: REGRESSION analysis; Subject Term: NONLINEAR programming; Subject Term: MATHEMATICAL statistics; Subject Term: MATHEMATICAL programming; Author-Supplied Keyword: constraints; Author-Supplied Keyword: inequality; Author-Supplied Keyword: iteration; Author-Supplied Keyword: least squares; Author-Supplied Keyword: nonlinear equations; Author-Supplied Keyword: nonlinear programming; Author-Supplied Keyword: nonlinear regression; Author-Supplied Keyword: quadratic programming; Number of Pages: 6p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1145/361237.361248
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Raub, William F
T1 - Automated information-handling in pharmacology research
JO - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 1157-1165. 11 Illus. 8 Ref. See Isa 72-3078/y
JF - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 1157-1165. 11 Illus. 8 Ref. See Isa 72-3078/y
Y1 - 1972///
M3 - Book Chapter
N1 - Accession Number: ISTA0703249; Raub, William F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Jones, Thomas L
T1 - A computer model of simple forms of learning in infants
JO - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 885-895. 15 Illus. 18 Ref. See Isa 72-3078/y
JF - In American Federation Of Information Processing Societies. Afips Conference Proceedings, Volume 40. 1972 Spring Joint Computer Conference, May 16-18, 1972, Atlantic City, New Jersey. P. 885-895. 15 Illus. 18 Ref. See Isa 72-3078/y
Y1 - 1972///
M3 - Book Chapter
N1 - Accession Number: ISTA0703201; Jones, Thomas L 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Wright, L. J.;
AU - Lipsett, M. B.;
AU - Ross, G. T.;
AU - Wolff, S. M.;
T1 - Effects of dexamethasone and aspirin on the responses to endotoxin in man
CT - Effects of dexamethasone and aspirin on the responses to endotoxin in man
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1972/01/01/
VL - 34
IS - Jan
SP - 13
EP - 17
AD - National Institutes of Health, Building 10, Room 11N-232, Bethesda, Maryland 20014
N1 - Accession Number: 11-0526; Language: English; Chemical Name: Dexamethasone--50-02-2 Aspirin--50-78-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- dexamethasone; References: 18; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The effects of aspirin and dexamethasone on the fever, clinical symptoms, granulocyte response, plasma cortisol and growth hormone levels produced by bacterial endotoxin were investigated. Dexamethasone, and to a lesser extent aspirin, suppressed much of the fever and undesirable symptoms. Granulocyte response was enhanced by dexamethasone but was unchanged by aspirin. The increase in plasma cortisol levels was unaffected by these antipyretic agents, although dexamethasone diminished the number of positive growth hormone responses to endotoxin. There was no correlation between fever and either plasma cortisol or growth hormone response.
KW - Dexamethasone--fever-;
KW - Aspirin--fever-;
KW - Steroids, cortico---dexamethasone--effects, bacterial endotoxin fever, in patients;
KW - Fever--endotoxins--bacterial, effects, aspirin or dexamethasone, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Heller, Stephen R
AU - Koniver, Deena A
T1 - Computer generation of wiswesser line notation
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1972///
VL - 12
IS - 1
M3 - Article
SP - 56
EP - 59
SN - 00219576
AB - The computer program for the generation of wiswesser line notation (wln) has been extended to include polyfused rings, methly contraction rules, chain of two ring systems, some perifused rings, some chelates, and some metallocenes. Salts and ions are also handled, but in a different manner than what is normally found. Multipliers are not used by the program. The normal input for the wln generation is an easy input program using a rand tablet; however, teletype and connection table input can also used in most cases.
N1 - Accession Number: ISTA0701458; Heller, Stephen R 1; Koniver, Deena A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1972, Vol. 12 Issue 1, p56; Note: Update Code: 0700; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Donnelly, Edward F.
AU - Dent, James K.
AU - Murphy, Dennis L.
AU - Mignone, Robert J.
T1 - COMPARISON OF TEMPORAL LOBE EPILEPTICS AND AFFECTIVE DISORDERS ON THE HALSTEAD-REITAN TEST BATTERY.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1972/01//
VL - 28
IS - 1
M3 - Article
SP - 61
EP - 62
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study wherein "brain damage" is defined as recorded EEG abnormalities in temporal lobe epileptics and "without brain damage" is defined as affective disorders with no neurological deficits. Thus, the study explores the apparent implications of the degree of impairment in serious psychological disorders. Since temporal lobe epileptics generally show less neuropathology than other types of brain damage and since most subjects with affective disorders were diagnosed psychotic, expectation would favor a similar degree of impairment in both diagnostic groups.
KW - CEREBROVASCULAR disease
KW - BRAIN damage
KW - AFFECTIVE disorders
KW - PATHOLOGICAL psychology
KW - NEUROLOGY
KW - ELECTROENCEPHALOGRAPHY
N1 - Accession Number: 15847437; Donnelly, Edward F. 1 Dent, James K. 1 Murphy, Dennis L. 1 Mignone, Robert J. 2; Affiliation: 1: National Institute of Mental Health, Bethesda, Maryland. 2: National Institute of Neurological Diseases and Stroke, Bethesda, Maryland.; Source Info: Jan1972, Vol. 28 Issue 1, p61; Subject Term: CEREBROVASCULAR disease; Subject Term: BRAIN damage; Subject Term: AFFECTIVE disorders; Subject Term: PATHOLOGICAL psychology; Subject Term: NEUROLOGY; Subject Term: ELECTROENCEPHALOGRAPHY; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Archard, Howell O.
AU - Tarpley, Jr., Thomas M.
T1 - Clinicopathologic and histochemical characterization of submucosal deposits in snuff dipper's keratosis.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1972/01//
VL - 1
IS - 1
M3 - Article
SP - 3
EP - 11
SN - 03009777
AB - The article reports on the clinicopathologic correlation and histochemical characterization of submucosal deposits from three patients with snuff dipper's keratosis. Each patient underwent a thorough oral examination, and a complete history was obtained concerning the kind of snuff used, the frequency and duration of application, and other tobacco habits. A biopsy of the clinical white lesion was then obtained taking care to include submucosa and associated glandular elements. The findings indicates the staining characteristics of the submucosal deposits in the three cases of snuff dipper's keratosis.
KW - SNUFF
KW - PATIENTS
KW - BIOPSY
KW - DIAGNOSIS
KW - KERATOSIS
KW - SMOKELESS tobacco
N1 - Accession Number: 14879377; Archard, Howell O. 1 Tarpley, Jr., Thomas M. 1; Affiliation: 1: Section of Diagnostic Pathology, Laboratory of Experimental Pathology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.; Source Info: 1972, Vol. 1 Issue 1, p3; Subject Term: SNUFF; Subject Term: PATIENTS; Subject Term: BIOPSY; Subject Term: DIAGNOSIS; Subject Term: KERATOSIS; Subject Term: SMOKELESS tobacco; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1600-0714.ep14879377
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Perrine, T. D.;
AU - Atwell, L.;
AU - Tice, I. B.;
AU - Jacobson, A. E.;
AU - May, E. L.;
T1 - Analgesic activity as determined by the Nilsen Method
CT - Analgesic activity as determined by the Nilsen Method
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/01/01/
VL - 61
IS - Jan
SP - 86
EP - 88
SN - 00223549
AD - Laboratory of Chemistry and Biomedical Engineering and Instrument Branch, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4839; Language: English; References: 14; Journal Coden: JPMSAE; Section Heading: Methodology
N2 - The Nilsen method for determining analgesic activity (pain stimulus and electrical pulsations to the mouse tail) was compared with the hotplate procedure for several compounds including ""pure'' analgesics, i.e. agonists (morphine, codeine, and meperidine), a known ""pure'' antagonist (naloxone), several so-called mixed agonist-antagonists (nalorphine, pentazocine, and cyclazocine), one antagonist that appears to be naloxonelike, and 2 compounds of relatively unknown pharmacology. The results obtained confirm the validity of the Nilsen test for the agonists and indicate its superior predictive value (to the hotplate, Smith D'Amour, and perhaps writhing methods) for man with those substances possessing antagonist properties. Refinements in methodology and instrumentation are described. Illustrations and photographs are included.
KW - Methodology--analgesics--screening, Nilsen method, evaluation;
KW - Equipment--analgesics--screening, Nilsen method, evaluation;
KW - Analgesics and antipyretics--methodology--screening, Nilsen method, evaluation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Epstein, E. H.;
AU - Levin, D. L.;
AU - Croft, J. D.;
AU - Lutzner, M. A.;
T1 - Mycosis fungoides
CT - Mycosis fungoides
JO - Medicine (Baltimore)
JF - Medicine (Baltimore)
Y1 - 1972/01/01/
VL - 15
IS - Jan
SP - 61
EP - 72
AD - National Institutes of Health, Room 12 N238, Building 10, Bethesda, Maryland 20014
N1 - Accession Number: 9-2619; Language: English; References: 27; Journal Coden: MEDIAV; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Richard A. Hutchinson
N2 - This article summarizes the clinical course and pathological findings of 144 patients with mycosis fungoides at NIH. All mycosis fungoides patients studied between 1954-1969 by NIH are summarized as to onset, first clinical signs, pathological findings, survival and prognosis, and response to therapy. During the 15 years of the study, over 30 types of therapy were used. The summary includes the most common forms and their effects on patients' prognoses.
KW - Mycosis fungoides--in humans--clinical course, pathological findings, and response to therapy;
KW - Fungicides--mycosis fungoides--in humans, clinical course, pathological findings, and response to therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Wyatt, H V
T1 - When does information become knowledge?
JO - Nature 235(5333), 86-89 (1972 January 14). 1 Illus. 1 Tab. 38 Ref
JF - Nature 235(5333), 86-89 (1972 January 14). 1 Illus. 1 Tab. 38 Ref
Y1 - 1972///
M3 - Book Chapter
AB - By considering a specific example from molecular biology, the author examines the factors that determine the transformation of scientific information into knowledge. He concludes that new information can be assimilated only when it can be fitted without too much difficulty into accepted ideas. As information it is unrecogized until it is transformed into knowledge.
N1 - Accession Number: ISTA0701803; Wyatt, H V 1; Affiliations: 1 : National Cancer Institute, National Institutes Of Health, Bethesda, Maryland.; Source Info: 1972; Note: Update Code: 0700; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Lystad, Mary Hanemann
T1 - Social Alienation: A Review of Current Literature.
JO - Sociological Quarterly
JF - Sociological Quarterly
Y1 - 1972///Winter72
VL - 13
IS - 1
M3 - Article
SP - 90
EP - 113
SN - 00380253
AB - In recent years considerable attention has been focused on delineation of the concept of alienation and on measurement of its relationship to modern social structure and function. This paper reviews the alienation literature, largely empirically oriented, for the last decade. Included with works of primarily theoretical and methodological importance are substantive studies of the relationships between the alienated individual and his social order. Suggestions for further research are given. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Quarterly is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALIENATION (Social psychology)
KW - SOCIAL structure
KW - FORMAL sociology
KW - SOCIAL systems
KW - SCIENTIFIC literature
KW - EMPIRICISM
KW - SOCIAL order
KW - SOCIAL conflict
N1 - Accession Number: 14009832; Lystad, Mary Hanemann 1; Affiliation: 1: National Institute of Mental Health; Source Info: Winter72, Vol. 13 Issue 1, p90; Subject Term: ALIENATION (Social psychology); Subject Term: SOCIAL structure; Subject Term: FORMAL sociology; Subject Term: SOCIAL systems; Subject Term: SCIENTIFIC literature; Subject Term: EMPIRICISM; Subject Term: SOCIAL order; Subject Term: SOCIAL conflict; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-40851-004
AN - 2013-40851-004
AU - Bell, Richard Q.
AU - Waldrop, Mary F.
AU - Weller, George M.
T1 - A rating system for the assessment of hyperactive and withdrawn children in preschool samples.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1972/01//
VL - 42
IS - 1
SP - 23
EP - 34
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Bell, Richard Q., Child Research Branch, National Institute of Mental Health, Building 15K, 9000 Rockville Pike, 200, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-40851-004. PMID: 5013504 Partial author list: First Author & Affiliation: Bell, Richard Q.; Child Research Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Audits; Preschool Teachers. Classification: Educational Psychology (3500). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 1972.
AB - Six aspects of hyperactivity and three of withdrawal can be rated by preschool teachers on a weekly basis and quickly converted into two factor scores to keep a running account of the status of children in a group. Applications of the system could include clinical studies of response to treatment, and separate identification of children unlikely to respond to group enrichment programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical studies
KW - preschool teachers
KW - withdrawn children
KW - group enrichment programs
KW - 1972
KW - Clinical Audits
KW - Preschool Teachers
KW - 1972
DO - 10.1111/j.1939-0025.1972.tb02467.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40851-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1972-26679-001
AN - 1972-26679-001
AU - Perez-Cruet, J.
AU - Tagliamonte, A.
AU - Tagliamonte, P.
AU - Gessa, G. L.
T1 - Changes in brain serotonin metabolism associated with fasting and satiation in rats.
JF - Life Sciences
JO - Life Sciences
JA - Life Sci
Y1 - 1972/01//
VL - 11
IS - 1, Pt. 2
SP - 31
EP - 39
CY - Netherlands
PB - Elsevier Science
SN - 0024-3205
N1 - Accession Number: 1972-26679-001. Partial author list: First Author & Affiliation: Perez-Cruet, J.; National Institutes of Health, Lab. of Chemical Pharmacology, Bethesda, Md. Release Date: 19721001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Food Intake; Metabolism. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 9. Issue Publication Date: Jan, 1972.
AB - Rats fasted for 24 hr. were fed for 2 hr., after which time food was removed. Food intake decreased brain 5-hydroxyindole acetic acid and tryptophan levels by about 22% and 27%, respectively, but did not modify brain serotonin concentration. These changes persisted for about 6 hr. The synthesis rate of brain serotonin was about 30% lower in Ss fed for 2 hr. than in Ss fasted for 24 hr. Food intake produced changes in plasma tryptophan opposite to those produced in brain. Feeding also decreased brain serotonin turnover in hypophysectomized Ss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - brain serotonin metabolism
KW - fasting vs. satiation
KW - rat
KW - 1972
KW - Brain
KW - Food Intake
KW - Metabolism
KW - Rats
KW - 1972
DO - 10.1016/0024-3205(72)90149-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1972-26679-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40851-009
AN - 2013-40851-009
AU - Torrey, E. Fuller
T1 - What Western psychotherapists can learn from witchdoctors.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1972/01//
VL - 42
IS - 1
SP - 69
EP - 76
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Torrey, E. Fuller, National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1 - Accession Number: 2013-40851-009. PMID: 5013510 Partial author list: First Author & Affiliation: Torrey, E. Fuller; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1971, Washington, DC, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Ethnocentrism; Expectations; Physicians; Psychotherapists. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 8. Issue Publication Date: Jan, 1972.
AB - Western psychotherapists have been remarkably ethnocentric in their view of themselves. They have failed to learn from their counterparts in other cultures, the witchdoctors. This paper reviews some of the things they can learn, namely the importance of 1) the Principle of Rumpelstiltskin, 2) the personal qualities of the therapist, 3) the patients' expectations, and 4) the techniques of therapy. It is concluded that we have much to learn from witchdoctors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Western psychotherapists
KW - witchdoctors
KW - ethnocentrics
KW - cultures
KW - patients expectations
KW - 1972
KW - Ethnocentrism
KW - Expectations
KW - Physicians
KW - Psychotherapists
KW - 1972
DO - 10.1111/j.1939-0025.1972.tb02472.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40851-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40851-011
AN - 2013-40851-011
AU - Symmes, Jean S.
AU - Rapoport, Judith L.
T1 - Unexpected reading failure.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1972/01//
VL - 42
IS - 1
SP - 82
EP - 91
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Symmes, Jean S., National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-40851-011. PMID: 5013512 Partial author list: First Author & Affiliation: Symmes, Jean S.; National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20160915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1971, Washington, DC, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Imagery; Learning Disabilities; Reading; Spatial Ability. Minor Descriptor: Patient History. Classification: Learning Disorders (3253). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Wide Range Achievement Test DOI: 10.1037/t49277-000; Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan, 1972.
AB - Eliminating children with any condition in medical history or present status that might indicate a predisposition to learning problems, the remaining population of 54 contained only one girl and was characterized by superiority in certain visual skills. A genetic linkage between spatial visualization and difficulty in acquiring reading skills is postulated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - learning problems
KW - medical history
KW - spatial visualization
KW - visual skills
KW - 1972
KW - Imagery
KW - Learning Disabilities
KW - Reading
KW - Spatial Ability
KW - Patient History
KW - 1972
DO - 10.1111/j.1939-0025.1972.tb02474.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40851-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2007-19564-000
AN - 2007-19564-000
AU - Maddi, Salvatore R.
AU - Costa, Paul T.
T1 - Humanism in personology: Allport, Maslow, and Murray.
Y1 - 1972///
CY - Piscataway, NJ, US
PB - Transaction Publishers
SN - 0-202-36173-X
SN - 978-0-202-36173-4
N1 - Accession Number: 2007-19564-000. Partial author list: First Author & Affiliation: Maddi, Salvatore R.; Department of Psychology and Social Behavior, School of Social Ecology, University of California, Irvine, CA, US. Reprinted: 2008. Release Date: 20080331. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. ISBN: 0-202-36173-X, Paperback; 978-0-202-36173-4, Paperback. Language: English. Major Descriptor: Humanism; Humanistic Psychology; Maslow (Abraham Harold); Personality; Psychologists. Minor Descriptor: Psychological Theories. Classification: Personality Psychology (3100). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 200.
AB - Through analysis of the lives and theories of the three major exponents of humanism, Allport, Maslow, and Murray, the authors have marshaled some compelling arguments for an alternative to the extreme behaviorism of Skinner and the logical positivism of Freud. This work is a concise, clear synthesis of both broad theoretical positions and specific concepts that underlie humanistic psychology. The 'Third Force' (humanism) suggests that man possesses both freedom and dignity and that he possesses them in the face of an often hostile and coercive society. Thus, exponents of humanism conducted their personality experiments in a natural environment, imposing few, if any, external controls. A compact example of critical evaluation at its best, Humanism in Personology stands alone in its successful attempt to correlate the theory of humanism as it exists today with an incisive study of the men who shaped its course. Maddi and Costa proceed from the level of metatheory to a lucid presentation of the specific constructs of three personality psychologists. The book contains an extensive theoretical summary table explaining the theoretical differences between Allport, Maslow, and Murray. Also featured is a comprehensive glossary of personality terms, which is exceedingly valuable for new students in the field. Intended as a supplementary text for undergraduate courses in personality, social psychology, human development, human socialization, or philosophy, this work is also a valuable resource for clinicians, teachers, guidance counselors, graduates, and undergraduates in psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - humanism
KW - personology
KW - Allport
KW - Maslow
KW - Murray
KW - theories
KW - humanistic psychology
KW - Third Force
KW - personality
KW - 1972
KW - Humanism
KW - Humanistic Psychology
KW - Maslow (Abraham Harold)
KW - Personality
KW - Psychologists
KW - Psychological Theories
KW - 1972
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Warmolts, J. R.;
AU - Engel, W. K.;
T1 - Benefit from alternate-day prednisone in myasthenia gravis
CT - Benefit from alternate-day prednisone in myasthenia gravis
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/01/06/
VL - 286
IS - Jan 6
SP - 17
EP - 20
SN - 00284793
AD - Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 9-1867; Language: English; Chemical Name: Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Five adults with myasthenia gravis of varying severity and duration were treated with long-term, high single dosage (100 mg.), alternate-day oral prednisone. Improvement in muscle function appeared 24 to 72 hours after the initiation of therapy and has been maintained from 6 to 17 months. Complete remission of symptoms was obtained in one patient in 4 months and has been maintained for 13 months.
KW - Prednisone--myasthenia gravis-;
KW - Steroids, cortico---prednisone--myasthenia gravis, therapy, high dose, in patients;
KW - Dosage--prednisone--high, myasthenia gravis, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MOSS, W. GLEN
T1 - Approval of Research Grants.
JO - Science
JF - Science
Y1 - 1972/01/07/
VL - 175
IS - 4017
M3 - Article
SP - 10
EP - 10
SN - 00368075
N1 - Accession Number: 85159885; MOSS, W. GLEN 1; Affiliations: 1: National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/ 7/1972, Vol. 175 Issue 4017, p10; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DANTE, M. L.
AU - CHRAMBACH, A.
T1 - Buffer Systems and PAGE.
JO - Science
JF - Science
Y1 - 1972/01/07/
VL - 175
IS - 4017
M3 - Article
SP - 95
EP - 95
SN - 00368075
N1 - Accession Number: 85159926; DANTE, M. L. 1; CHRAMBACH, A. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; 2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/ 7/1972, Vol. 175 Issue 4017, p95; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VAN BOXEL, JOHN A.
AU - STOBO, JOHN D.
AU - PAUL, WILLIAM E.
AU - GREEN, IRA
T1 - Antibody-Dependent Lymphoid Cell—Mediated Cytotoxicity: No Requirement for Thymus-Derived Lymphocytes.
JO - Science
JF - Science
Y1 - 1972/01/14/
VL - 175
IS - 4018
M3 - Article
SP - 194
EP - 196
SN - 00368075
AB - The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to K chains diminished this function, suggesting a role for bone marrow-derived lymphocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87423331; VAN BOXEL, JOHN A. 1; STOBO, JOHN D. 1; PAUL, WILLIAM E. 1; GREEN, IRA 1; Affiliations: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p194; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - STEWART, SARAH E.
AU - KASNIC JR., GEORGE
AU - DRAYCOTT, CATHERINE
AU - BEN, THERESA
T1 - Activation of Viruses in Human Tumors by 5-Iododeoxyuridine and Dimethyl Sulfoxide.
JO - Science
JF - Science
Y1 - 1972/01/14/
VL - 175
IS - 4018
M3 - Article
SP - 198
EP - 199
SN - 00368075
AB - Dimethyl sulfoxide added to cultures first treated with 5-iododeoxyuridine increased C-type virus production approximately tenfold in a human rhabdomyosarcoma cell line. 5-Iododeoxyuridine followed by dimethyl sulfoxide also activated a similar C-type virus in a metastatic tumor from a bronchial node taken from a 52-year-old male. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87423333; STEWART, SARAH E. 1; KASNIC JR., GEORGE 1; DRAYCOTT, CATHERINE 1; BEN, THERESA 2; Affiliations: 1: School of Medicine, Georgetown University, Washington, D.C. 20007; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p198; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WOLLBERG, ZVI
AU - NEWMAN, JOHN D.
T1 - Auditory Cortex of Squirrel Monkey: Response Patterns of Single Cells to Species-Specific Vocalizations.
JO - Science
JF - Science
Y1 - 1972/01/14/
VL - 175
IS - 4018
M3 - Article
SP - 212
EP - 214
SN - 00368075
AB - Most of the neurons tested in the superior temporal cortex of awake squirrel monkeys responded to recorded species-specific vocalizations. Some cells responded with temporally complex patterns to many vocalizations. Other cells responded with simpler patterns to only one call. Most cells lay between these two extremes. On-line deletion of parts of a vocalization revealed the role of temporal interactions in determining the nature of some responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87423341; WOLLBERG, ZVI 1; NEWMAN, JOHN D. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p212; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SEVER, JOHN L.
T1 - Subacute Sclerosing Panencephalitis Treatment.
JO - Science
JF - Science
Y1 - 1972/01/14/
VL - 175
IS - 4018
M3 - Article
SP - 220
EP - 223
SN - 00368075
N1 - Accession Number: 87423344; SEVER, JOHN L. 1; Affiliations: 1: National Intitute of Neurological Diseases and Stroke, National Institutes of Health Bethesda, Maryland 20014; Issue Info: 1/14/1972, Vol. 175 Issue 4018, p220; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHNEIDER, JOHN H.
T1 - Letters.
JO - Science
JF - Science
Y1 - 1972/01/21/
VL - 175
IS - 4019
M3 - Article
SP - 256
EP - 257
SN - 00368075
N1 - Accession Number: 87615451; SCHNEIDER, JOHN H. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1972, Vol. 175 Issue 4019, p256; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KWON-CHUNG, K. J.
T1 - Sexual Stage of Histoplasma capsulatum.
JO - Science
JF - Science
Y1 - 1972/01/21/
VL - 175
IS - 4019
M3 - Article
SP - 326
EP - 326
SN - 00368075
AB - Twelve primary subcultures of Histoplasma capsulatum, paired in all possible combinations on agar containing yeast extract and Alphacel, produced fertile cleistothecia, resembling those of Ajellomyces dermatitidis (Blastomyces dermatitidis). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87615479; KWON-CHUNG, K. J. 1; Affiliations: 1: Laboratory of Microbiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1972, Vol. 175 Issue 4019, p326; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Johnson, Donald W.
AU - Bernstein, Stuart
T1 - Classification of States Regarding Expanding Duties for Dental Auxiliaries and Selected Aspects of Dental Licensure -- 1970.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/02//
VL - 62
IS - 2
M3 - Article
SP - 208
EP - 215
PB - American Public Health Association
SN - 00900036
AB - A discussion is presented of the expanded functions of dental auxiliaries and the recognition of this development in terms of licensure. Further revision of dental practice acts is urged to meet the increasing demand for dental care. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Group dental practice
KW - Dental insurance
KW - Dental care
KW - Medical care
KW - Dental health maintenance organizations
KW - Dentistry
KW - Dentists
KW - Community dental services
KW - United States
N1 - Accession Number: 24294018; Johnson, Donald W. 1; Bernstein, Stuart 2; Affiliations: 1: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; 2: Division of Manpower Intelligence, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: Feb1972, Vol. 62 Issue 2, p208; Subject Term: Group dental practice; Subject Term: Dental insurance; Subject Term: Dental care; Subject Term: Medical care; Subject Term: Dental health maintenance organizations; Subject Term: Dentistry; Subject Term: Dentists; Subject Term: Community dental services; Subject: United States; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bagley, C. M., Jr.;
AU - DeVita, V. T.;
AU - Berard, C. W.;
AU - Canellos, G. P.;
T1 - Advanced lymphosarcoma: intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone
CT - Advanced lymphosarcoma: intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/02/01/
VL - 76
IS - Feb
SP - 227
EP - 234
SN - 00034819
AD - Building 10, Room 12N226, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-0579; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Prednisone--53-03-2; References: 29; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Thirty-five patients with advanced lymphosarcoma (32 without previous therapy) were treated with intensive 5-day courses of cyclophosphamide and prednisone, with vincristine given on the first day; this was repeated every 3 weeks until complete remission was attained or tumor resistance appeared. The dosages were as follows: cyclophosphamide, 400 mg./m\SU/2\BS/, orally; vincristine, 1.4 mg./m\SU/2\BS/, I.V. on the first day, and; prednisone 100 mg./m\SU/2\BS/ orally. Therapy was discontinued from days 6 through 21, then repeated. There were 20 complete and 12 partial responses. Of the complete remissions 89% lasted more than one year. Of all 35 patients, 79% lived more than one year. Survival of complete responders was significantly better than that of partial responders. Patients with more extensive disease had significantly shorter survival. Toxicity, chiefly leukopenia, was tolerable, reversible, and not cumulative. In inducing frequent and long-lasting complete remissions, this regimen appears superior to those previously reported.
KW - Cyclophosphamide--vincristine and prednisone-;
KW - Vincristine--cyclophosphamide and prednisone-;
KW - Prednisone--cyclophosphamide and vincristine-;
KW - Combined therapy--cyclophosphamide and prednisone and vincristine--lymphosarcoma, advanced, therapy, in patients;
KW - Antineoplastic agents--combined therapy--lymphosarcoma, advanced, in patients;
KW - Combined therapy--vincristine, cyclophosphamide and prednisone--lymphosarcoma, advanced, in patients;
KW - Combined therapy--prednisone, cyclophosphamide and vincristine--lymphosarcoma, advanced, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Anderson, L. G.
AU - Talal, N.
T1 - THE SPECTRUM OF BENIGN TO MALIGNANT LYMPHOPROLIFERATION IN SJÖGREN'S SYNDROME.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/02//
VL - 10
IS - 2
M3 - Article
SP - 199
EP - 221
PB - Wiley-Blackwell
SN - 00099104
AB - Clinical and pathological evidence suggests that a wide spectrum of lymphoproliferation exists in Sjögren's syndrome (SS), from benign disease with lymphoid infiltrates confined to glandular tissue on the one end, to widespread lymphoreticular malignancy on the other. In the middle of the spectrum are patients threatened by extraglandular extension of lymphoproliferation which is not clinically or histologically malignant and which apparently has the potential to regress with appropriate therapy or to progress to frank neoplasia. Illustrative patients are described. Over thirty other case reports associating 55 with pseudolymphoma, Waldenstrorn's macroglobulinaemia, reticulum cell sarcoma, or other lymphomas appear in the literature, Similar lymphoproliferative processes have been observed in other autoimmune diseases, in certain immune deficiency states, with hydantoin and other anticonvulsant drugs, and in experimental animal models. In SS, as in these other conthtions, it seems likely that a combination of genetic, immunologic, and viral or other unknown environmental factors plays a role in pathogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOPROLIFERATIVE disorders
KW - IMMUNOLOGIC diseases
KW - AUTOIMMUNE diseases
KW - LYMPHOMAS
KW - DISEASES
KW - LABORATORY animals
N1 - Accession Number: 14545352; Anderson, L. G. 1 Talal, N. 1; Affiliation: 1: National Institute of Dental Research and National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Feb72, Vol. 10 Issue 2, p199; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: IMMUNOLOGIC diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: LYMPHOMAS; Subject Term: DISEASES; Subject Term: LABORATORY animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Feldmann, Richard J
AU - Heller, Stephen R
AU - Shapiro, Kenneth P
T1 - An application of interactive computing-a chemical information system
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1972/02//
VL - 12
IS - 1
M3 - Article
SP - 41
EP - 47
SN - 00219576
AB - A collection of computer programs to do chemical information retrieval are described in terms of the interactions between the computer and the chemist. The medium of interaction is the language of the chemist-the structural diagram. In interacting with the computer, the chemist can graphically specify two-dimensional structures as queries and view structures as search results.
N1 - Accession Number: ISTA0701490; Feldmann, Richard J 1; Heller, Stephen R; Shapiro, Kenneth P; Affiliations: 1 : National Institutes Of Health, Bethesda,maryland.; Source Info: February 1972, Vol. 12 Issue 1, p41; Note: Update Code: 0700; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Miller, George A
T1 - Encoding and decoding wln
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1972/02//
VL - 12
IS - 1
M3 - Article
SP - 60
EP - 67
SN - 00219576
AB - This paper deals with the encoding and decoding of a wiswesser line national (wln). This problem so far has been addressed only from the point of a human. This paper discusses the encoding and decoding with exactness suitable for a computer, and is an outgrowth of a computer program now in operation at nih which automatically encodes and decodes wln.
N1 - Accession Number: ISTA0701460; Miller, George A 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: February 1972, Vol. 12 Issue 1, p60; Note: Update Code: 0700; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - McCallin, P. F.;
AU - Fuccillo, D. A.;
AU - Lay, A. C.;
AU - Gilkeson, M. R.;
AU - Traub, R. E.;
AU - \ET/;
T1 - Gamma globulin as prophylaxis against rubella-induced congenital anomalies
CT - Gamma globulin as prophylaxis against rubella-induced congenital anomalies
JO - Obstetrics and Gynecology (USA)
JF - Obstetrics and Gynecology (USA)
Y1 - 1972/02/01/
VL - 39
IS - Feb
SP - 185
EP - 189
SN - 00297844
AD - Department of Obstetrics and Gynecology, Hawaii Permanente Medical Group, Honolulu, Hawaii) (Reprints: c/o J. L. Sever, MD, National Institute of Nurological Diseases and Stroke, Bldg. 36, Rm. 5D04, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-4422; Language: English; References: 8; Journal Coden: OBGNAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Thomas R. Simpson
N2 - Between September, 1964 and September, 1965, 83 women who reported exposure to rubella during the first 8 weeks of pregnancy were given 20 ml. of gamma globulin. Two types were used, one having a high titer of rubella antibody (HI titer 512), and the other a low titer (HI titer 64). Of these 83 patients, 41 were found to be susceptible to rubella, 5 had seroconversions, none developed clinical rubella and none of the infants had congenital rubella. Among 13 other women who were exposed but did not receive gamma globulin, 6 were susceptible and one had a seroconversion. Another group of 949 gravidas reported no exposure during the first trimester. Of these women, 325 were susceptible, 22 has seroconversions, 10 had clinical disease and one child had congenital rubella. There was no clear-cut evidence that the incidence of seroconversion was reduced by the use of either gamma globulin preparation.
KW - Globulins--immune serum--effects, prophylaxis against rubella-induced congenital anomalies, in women;
KW - Rubella--toxicity--prophylaxis, against congenital anomalies, use of gamma globulin, in women;
KW - Teratogenicity--rubella--prophylaxis, use of gamma globulin, in women;
KW - Serums--globulins--immune serum, prophylaxis against rubella-induced congenital anomalies, in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kennedy Jr., Thomas J.
AU - Sherman, John F.
AU - Lamont-Havers, R. W.
T1 - Factors Contributing to Current Distress in the Academic Community.
JO - Science
JF - Science
Y1 - 1972/02/11/
VL - 175
IS - 4022
M3 - Article
SP - 599
EP - 607
SN - 00368075
N1 - Accession Number: 85116756; Kennedy Jr., Thomas J. 1; Sherman, John F. 1; Lamont-Havers, R. W. 1; Affiliations: 1: Training, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/11/1972, Vol. 175 Issue 4022, p599; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SACHS, DAVID H.
AU - PAINTER, ELIZABETH
T1 - Improved Flow Rates with Porous Sephadex Gels.
JO - Science
JF - Science
Y1 - 1972/02/18/
VL - 175
IS - 4023
M3 - Article
SP - 781
EP - 782
SN - 00368075
AB - The use of an internal support of siliconized glass beads 6 millimeters in diameter was found to improve markedly the flow rates obtainable with porous Sephadex gels without significant alteration of other properties of the gels. The method may be generally applicable in situations where rapid separations on Sephadex are required. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159973; SACHS, DAVID H. 1; PAINTER, ELIZABETH 2; Affiliations: 1: Laboratory of Chemical Biology, National Institute of Arthritis anid Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Trans plantation U.nit, General Surgical Services, Massachusetts General Hoospital, Bostoun 02114; Issue Info: 2/18/1972, Vol. 175 Issue 4023, p781; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Catalona, W. J.;
AU - Taylor, P. T.;
AU - Rabson, A. S.;
AU - Chretien, P. B.;
T1 - Method for dinitrochlorobenzene contact sensitization: a clinicopathological study
CT - Method for dinitrochlorobenzene contact sensitization: a clinicopathological study
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/02/24/
VL - 286
IS - Feb 24
SP - 399
EP - 402
SN - 00284793
AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2297; Language: English; Chemical Name: Dinitrochlorobenzene--25567-67-3; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Methodology
N2 - To facilitate measurement of cell mediated immune responses, a method for quantitative clinical evaluation of contact sensitization to dinitrochlorobenzene (DNCB) was devised and used in 40 patients with cancer. When a sensitizing dose is applied, the immediate reaction produced expresses a general inflammatory response. Sensitization is expressed by the occurrence of a spontaneous flare 7 to 14 days later, or by the reaction to a challenge dose of DNCB. Use of a sensitizing dose of 2000 mcg. and a relatively weak challenge dose of 50 mcg. yielded a satisfactory incidence of sensitization with a low proportion of irritative inflammatory reactions.
KW - Dinitrochlorobenzene--sensitivity-;
KW - Tests--skin--dinitrochlorobenzene, sensitivity, measurement of cell mediated immune responses, in cancer patients;
KW - Methodology--dinitrochlorobenzene--sensitivity, tests, skin, measurement of cell mediated immune responses, in cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hill, D. A.;
AU - Baron, S.;
AU - Perkins, J. C.;
AU - Worthington, M.;
AU - Van Kirk, J. E.;
AU - \ET/;
T1 - Evaluation of an interferon inducer in viral respiratory disease
CT - Evaluation of an interferon inducer in viral respiratory disease
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/02/28/
VL - 219
IS - Feb 28
SP - 1179
EP - 1184
AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Bethesda, Maryland 20014
N1 - Accession Number: 9-2112; Language: English; Trade Name: Poly I:Poly C; Generic Name: Polyinosinic-polycytidylic acid; Chemical Name: Polyinosinic-polycytidylic acid--24939-03-5 Interferon--9008-11-1; Therapeutic Class: (8:18); AHFS Class: Virucides polyinosinic-polycytidylic acid; References: 17; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - To evaluate the effect of an interferon inducer on respiratory tract virus infection, poly I.poly C (polyinosinic-polycytidylic acid), a synthetic double-stranded RNA interferon inducer, was administered intranasally to volunteers for a 7 day period beginning one day prior to inoculation of rhinovirus 13 or type A2 influenza virus/Hong Kong/68. On the day before virus challenge, each volunteer was given 7.0 mg. (0.1 mg./kg.) of poly I.poly C divided into 14 intranasal doses of 0.5 mg. (0.5 ml.) administered one hour apart. The drug was administered by instillation of 0.25 ml. into each nostril by drops, after which the patient remained supine for 2 to 3 minutes. On the following day, all volunteers were challenged with virus by intranasal inoculation with drops. On this day and on the subsequent 5 days, each patient was given 3.5 mg. (0.05 mg./kg./day) of poly I.poly C (or saline diluent) per day in divided doses of 0.5 mg. (0.5 ml.) every 2 hours for 7 doses. In 3 separate trials, toxic effects were not detected and there was a small, but definite, reduction in symptoms of upper respiratory tract illness associated with drug treatment. However, there was a variable effect on the pattern of virus infection. In only one of the 2 rhinovirus studies was a reduction of virus shedding observed. Treatment did not decrease the shedding of type A2 influenza virus. The minimal amounts of nasal interferon stimulated by the intranasally administered poly I.poly C may have been responsible for the less-than-optimal results obtained.
KW - Polyinosinic-polycytidylic acid--virucides-;
KW - Interferon--inducers-;
KW - Virucides--polyinosinic-polycytidylic acid--effects, on viral respiratory tract infections, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lee, H. G.;
T1 - Aspects on the effect of thioxanthone on Schistosoma mansoni in mice and in vitro
CT - Aspects on the effect of thioxanthone on Schistosoma mansoni in mice and in vitro
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1972/03/01/
VL - 46
IS - Mar
SP - 397
EP - 402
AD - Laboratory of Parasitic Diseases, National Institutes of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014) (Reprint: George Williams Hooper Foundation, San Francisco Medical Center, University of California, San Francisco, California
N1 - Accession Number: 10-1127; Language: English; Chemical Name: Hycanthone--3105-97-3; References: 21; Journal Coden: BWHOA6; Section Heading: Preliminary Drug Testing; Abstract Author: Walter F. Stanaszek
N2 - The parasiticidal and sublethal effects of lucanthone and hycanthone were investigated in both male and female S. mansoni in infected mice and in vitro. Chemotherapy consisted of (1) 5 daily doses of lucanthone by gavage; (2) 5 daily doses of stibophen I.P.; or (3) a single I.M. dose of hycanthone base dissolved in castor oil. In vitro assays were performed with hycanthone methanesulfonate using the Lee-Michaels method. Results indicated that male worms were more susceptible to the lethal actions of the drugs than were females. It appeared that about 70% of male worms were killed with 25 mg./kg. of hycanthone vs. 30% of females with 50 mg./kg. The hycanthone methanesulfonate proved to be highly active against \IT/S. mansoni\OK/ in in vitro studies, again with a greater killing effect on male worms. In comparison with other antischistosomal drugs, thioxanthone treatment may warrant scrutiny in terms of its effect on prevalence and magnitude of reinfection.
KW - Lucanthone--effects-;
KW - Hycanthone--effects-;
KW - Schistosomicides--lucanthone--effects, in vitro and in mice;
KW - Schistosomicides--hycanthone--effects, in vitro and in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kay, D. C.;
AU - Jasinski, D. R.;
AU - Eisenstein, R. B.;
AU - Kelly, O. A.;
T1 - Quantified human sleep after pentobarbital
CT - Quantified human sleep after pentobarbital
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1972/03/01/
VL - 13
IS - Mar-Apr
SP - 221
EP - 231
SN - 00099236
AD - National Institute of Mental Health, Lexington, Kentucky
N1 - Accession Number: 10-1177; Language: English; Chemical Name: Pentobarbital--76-74-4; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics pentobarbital; References: 75; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Methodology; Pharmacology
N2 - Pentobarbital I.M. (75, 150, 300 mg./70 kg.) and placebo were given to 8 male post-addict subjects at weekly intervals. After 4 adaptation nights, the drug dosages were crossed over to show drug effects. Pentobarbital decreased rapid eye movement sleep (REMS) by decreasing the number and duration of REMS episodes and by delaying the onset of the first REMS episode, without measurably changing the period of the REMS cycle. It was suggested that the reduction of REMS and other sleep indicators can be used as a standard effect with which to determine equivalent doses of barbiturates and similar hypnotics.
KW - Pentobarbital--effects-;
KW - Sedatives and hypnotics--pentobarbital--effects, on sleep patterns, in former addicts;
KW - Toxicity--pentobarbital--studies, effects, on sleep patterns, in former addicts;
KW - Methodology--pentobarbital--effects, on sleep patterns, in former addicts;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J. E.
T1 - Studies on IgA of the Guinea-Pig.
JO - Immunology
JF - Immunology
Y1 - 1972/03//
VL - 22
IS - 3
M3 - Article
SP - 333
EP - 345
PB - Wiley-Blackwell
SN - 00192805
AB - The secretory immunoglobulin of the guinea-pig, IgA, was antigenically unique when compared with the 7Sγ1-, 7Sγ2- and γM-globulins, although it did share Fab determinants in common with the 7S&gamma2 globulin. Specific antigen binding capacity was detected in serum IgA after sequential oral and parenteral sensitization with purified protein antigens. IgA was prominent in saliva and succus entericus; in colostrum its concentration was 4–8 times that in normal serum. IgA in serum and secretory fluids sedimented at similar rates (≈12S), although colostral IgA contained an additional ≈16S population. Serum and secretory IgA appeared antigenically identical, however, serum IgA was especially sensitive to mild reductive procedures and became ≈7S after treatment. Serum IgA migrated as a β-protein on electrophoresis and was faster than IgA of colostrum. Antisera to IgA were produced by a procedure which involved simple precipitation of secretory IgA with an antiserum containing antibodies to common determinants of guinea-pig Ig. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - PROTEINS
KW - SPUTUM
KW - COLOSTRUM
KW - IMMUNE serums
N1 - Accession Number: 14514637; Coe, J. E. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Mar72, Vol. 22 Issue 3, p333; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEINS; Subject Term: SPUTUM; Subject Term: COLOSTRUM; Subject Term: IMMUNE serums; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Waters, J. A.;
AU - Kondo, Y.;
AU - Witkop, B.;
T1 - Photochemistry of steroids
CT - Photochemistry of steroids
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/03/01/
VL - 61
IS - Mar
SP - 321
EP - 334
SN - 00223549
AD - Laboratory of Chemistry, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland 20014
N1 - Accession Number: 11-4487; Language: English; References: 128; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - Photorearrangements, photoadditions, photoreductions, and photooxidations are discussed in this review on the photochemistry of steroids. Numerous reactions are described, and the approaches are often applicable to other models besides steroids.
KW - Steroids--photochemistry--review;
KW - Photochemistry--steroids--review;
KW - Stability--steroids--photochemistry, review;
KW - Oxidation--steroids--photo, review of photochemistry;
KW - Reduction--steroids--photo, review of photochemistry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hoel, David G.
T1 - An Inverse Stopping Rule for Play-the-Winner Sampling.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1972/03//
VL - 67
IS - 337
M3 - Article
SP - 148
SN - 01621459
AB - Sobel and Weiss [2] have given an inverse sampling stopping rule for selecting the better of two binomial populations. Sampling is done by the play-the-winner method. By including the number of failures in the Sobel-Weiss stopping rule a truncated procedure is obtained with good general properties. In particular, excessive sample sizes are avoided when the population probabilities are small. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - MATHEMATICAL statistics
KW - PROBABILITY theory
KW - MATHEMATICAL models
KW - STATISTICS
KW - BINOMIAL distribution
KW - SAMPLE size (Statistics)
KW - WINNERS
KW - POPULATION
N1 - Accession Number: 4603947; Hoel, David G. 1; Affiliations: 1: Mathematical statistician, Biometry Branch, National institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, N.C. 27709.; Issue Info: Mar1972, Vol. 67 Issue 337, p148; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: SAMPLE size (Statistics); Subject Term: WINNERS; Subject Term: POPULATION; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Weiss, George H.
T1 - Random Counts in Scientific Work: Volume 1--Random Counts in Model, and Structure; Volume 2--Biomedical and Social Sciences, Volume 3--Physical Sciences, Geosciences and Business.
JO - Operations Research
JF - Operations Research
Y1 - 1972/03//Mar/Apr72
VL - 20
IS - 2
M3 - Book Review
SP - 455
EP - 456
PB - INFORMS: Institute for Operations Research
SN - 0030364X
AB - Reviews the books "Random Counts in Scientific Work," Volume 1: Random Counts in Models and Structures, Volume 2: Biomedical and Social Sciences, and Volume 3: Physical Sciences, Geosciences and Business, edited by G. P. Patil.
KW - SCIENCE
KW - NONFICTION
KW - PATIL, G. P.
KW - RANDOM Counts in Scientific Work (Book)
N1 - Accession Number: 8604193; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Mar/Apr72, Vol. 20 Issue 2, p455; Subject Term: SCIENCE; Subject Term: NONFICTION; Reviews & Products: RANDOM Counts in Scientific Work (Book); People: PATIL, G. P.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Weiss, George H.
T1 - Computational Methods in Optimization, A Unified Approach.
JO - Operations Research
JF - Operations Research
Y1 - 1972/03//Mar/Apr72
VL - 20
IS - 2
M3 - Book Review
SP - 456
EP - 456
PB - INFORMS: Institute for Operations Research
SN - 0030364X
AB - Reviews the book "Computational Methods in Optimization: A Unified Approach," by E. Polak.
KW - MATHEMATICAL optimization
KW - NONFICTION
KW - POLAK, E.
KW - COMPUTATIONAL Methods in Optimization: A Unified Approach (Book)
N1 - Accession Number: 8604195; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Mar/Apr72, Vol. 20 Issue 2, p456; Thesaurus Term: MATHEMATICAL optimization; Subject Term: NONFICTION; Reviews & Products: COMPUTATIONAL Methods in Optimization: A Unified Approach (Book); People: POLAK, E.; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - FLAMM, W. G.
AU - FISHBEIN, L.
T1 - Mutagenic Agents.
JO - Science
JF - Science
Y1 - 1972/03/03/
VL - 175
IS - 4025
M3 - Article
SP - 980
EP - 980
SN - 00368075
N1 - Accession Number: 85160010; FLAMM, W. G. 1; FISHBEIN, L. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p980; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HANKER, JACOB S.
AU - ANDERSON, WINSTON A.
AU - BLOOM, FLOYD E.
T1 - Osmiophilic Polymer Generation: Catalysis by Transition Metal Compounds in Ultrastructural Cytochemistry.
JO - Science
JF - Science
Y1 - 1972/03/03/
VL - 175
IS - 4025
M3 - Article
SP - 991
EP - 993
SN - 00368075
AB - A transition metal compound that is bound in tissues by any appropriate cytochemical reaction may catalyze the generation of an insoluble osmiophilic polymer from organic monomers such as 3,3'-diaminobenzidine. When the polymers are treated with osmium tetroxide, electron-opaque, insoluble osmium blacks (coordination polymers of osmium) are formed at the sites of the particular macromolecule or enzyme permitting its light, and electron, microscopic localization. This approach represents a distinct advantage over earlier cytochemical methods because the shorter incubation time needed here results in less artifactual deposition of metal ions, and less tendency to crystallize the reaction product. In addition, the shorter incubation times permit longer fixation of tissues and hence less artifact due to enzyme diffusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160016; HANKER, JACOB S. 1; ANDERSON, WINSTON A. 2; BLOOM, FLOYD E. 3; Affiliations: 1: Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill 27514; 2: Department of Anatomy, University of Chicago, Chicago, Illinois 60637; 3: Laboratory of Neuropharmacology, Division of Special Mental Health, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p991; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FREESE, ERNST
T1 - Prospects of Gene Therapy.
JO - Science
JF - Science
Y1 - 1972/03/03/
VL - 175
IS - 4025
M3 - Article
SP - 1024
EP - 1025
SN - 00368075
N1 - Accession Number: 85160033; FREESE, ERNST 1; Affiliations: 1: Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 3/1972, Vol. 175 Issue 4025, p1024; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Duttera, M. J.;
AU - Gallelli, J. F.;
AU - Kleinman, L. M.;
AU - Tangrea, J. A.;
AU - Wittgrove, A. C.;
T1 - Intrathecal methotrexate
CT - Intrathecal methotrexate
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1972/03/04/
VL - 1
IS - Mar 4
SP - 540
SN - 00237507
AD - Leukemia Service, Medicine, Branch, National Cancer Institute; and Pharmacy and Pharmaceutical Development Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2411; Language: English; Trade Name: Cytosine arabinoside; Generic Name: Cytarabine; Chemical Name: Methotrexate--59-05-2 Cytarabine--147-94-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents cytarabine; References: 8; Publication Type: Letters; Journal Coden: LANCAO; Section Heading: Pharmaceutics; Abstract Author: Joan Lentine
N2 - Data are presented which illustrate the wide variation in pH and osmolarity that can occur depending on how methotrexate and cytosine arabinoside (cytarabine) are prepared for intrathecal injection. Solutions used to reconstitute the samples included Sodium Chloride Injection \IT/U.S.P.\OK/, Bacteriostatic Water for Injection \IT/U.S.P.\OK/, and Elliott's B solution (an artificial spinal fluid containing in each ml. 7.3 mg. NaCl, 0.3 mg. Kcl, 0.2 mg. CaCl\IF/2\BS/.2 H\IF/2\BS/O, 0.3 mg. MgSO\IF/4\BS/. 7 H\IF/2\BS/O, 0.2 mg. sodium phosphate, dibasic 7H\IF/2\BS/O, 0.8 mg. dextrose, 1.9 mg. sodium bicarbonate, and 0.1 mcg. phenol red). In reconstituting both methotrexate and cytosine arabinoside, the most nearly physiological solution was obtained by using Elliott's B solution exclusively. The use of Elliott's B solution is recommended to prevent administration of intrathecal drugs which have unphysiological \IT/p\OK/H and osmolarity.
KW - Methotrexate--injections-;
KW - Cytarabine--injections-;
KW - Injections--methotrexate--intrathecal, diluents cause variation in pH and osmolarity;
KW - Antineoplastic agents--methotrexate--injections, intrathecal, diluents cause variation in pH and osmolarity;
KW - Hydrogen ion concentration--methotrexate--injections, intrathecal, variation due to diluents;
KW - Injections--cytarabine--intrathecal, diluents cause variation in pH and osmolarity;
KW - Antineoplastic agents--cytarabine--injections, intrathecal, diluents cause variation in pH and osmolarity;
KW - Hydrogen ion concentration--cytarabine--injections, intrathecal, variation due to diluents;
KW - Vehicles--injections--varying pH in cytarabine and methotrexate due to diluents;
KW - Osmolarity--methotrexate--injections, intrathecal, variation due to diluents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - SAROFF, H. A.
AU - MINTON, ALLEN P.
T1 - The Hill Plot and the Energy of Interaction in Hemoglobin.
JO - Science
JF - Science
Y1 - 1972/03/17/
VL - 175
IS - 4027
M3 - Article
SP - 1253
EP - 1255
SN - 00368075
AB - The Hill plot does not independently yield the average free energy of interaction per binding site, as has been proposed by Wyman, but rather the diflerence between the free energies of interaction on binding the first and last ligands. It is shown that additional data (or assumptions) and a model for cooperative behavior are requtired to obtain the average free energy of interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198745; SAROFF, H. A. 1; MINTON, ALLEN P. 1; Affiliations: 1: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Bethesda, Maryland 20014; Issue Info: 3/17/1972, Vol. 175 Issue 4027, p1253; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SAAVEDRA, JUAN M.
AU - AXELROD, JULIUS
T1 - Psychotoniimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro.
JO - Science
JF - Science
Y1 - 1972/03/24/
VL - 175
IS - 4028
M3 - Article
SP - 1365
EP - 1366
SN - 00368075
AB - The use of a sensitive enzymatic assay demonstrates that tryptamine occurs normally in rat brain. Intracisternal administration of [(14)C]tryptamine results in the formation of N-methyl-and dimethyltryptamine(a psychotomimetic compound)in the rat brain. An enzyme that converts tryptamine and N-methyl-tryptamine to N-methyl-and dimethyltryptamine was found to be present in rat and human brain. The N-methylation of tryptamine was inhibited by normally occurring compounds present in rat brain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437463; SAAVEDRA, JUAN M. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/24/1972, Vol. 175 Issue 4028, p1365; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PETRICCIANI, JOHN C.
AU - BINDER, MARC K.
AU - MERRIL, CARL R.
AU - GEIER, MARK R.
T1 - Galactose Utilization in Galactosemia.
JO - Science
JF - Science
Y1 - 1972/03/24/
VL - 175
IS - 4028
M3 - Article
SP - 1368
EP - 1370
SN - 00368075
AB - Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1-14C]galactose to 14CO2 to the same extent as normal cells, but did so at a significantly slower rate. The utilization of galactose in both normal and galactosemic cells was strongly inhibited by glucose at physiologic concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437465; PETRICCIANI, JOHN C. 1; BINDER, MARC K. 1; MERRIL, CARL R. 2; GEIER, MARK R. 2; Affiliations: 1: Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/24/1972, Vol. 175 Issue 4028, p1368; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Lemberger, L.;
AU - Weiss, J. L.;
AU - Watanabe, A. M.;
AU - Galanter, I. M.;
AU - Wyatt, R. J.;
AU - \ET/;
T1 - Delta-9-tetrahydrocannabinol: temporal correlation of the psychologic effects and blood levels after various routes of administration
CT - Delta-9-tetrahydrocannabinol: temporal correlation of the psychologic effects and blood levels after various routes of administration
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/03/30/
VL - 286
IS - Mar 30
SP - 685
EP - 688
SN - 00284793
AD - reprints: Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202
AD - Laboratory of Clinical Science and the Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, and the National Institute of General Medical Sciences, Bethesda, Maryland 20014
N1 - Accession Number: 9-3452; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; BiopharmaceuticsPharmacology
N2 - \D/\SU/9\BS/-Tetrahydrocannabinol (\SU/14\BS/C-\D/\SU/9\BS/-THC) was administered to 12 long-term marihuana (cannabis) smokers I.V., orally or by inhalation, and the drug's disposition, excretion and psychologic effects compared. All subjects received a dose of 10 \mu/Ci of \SU/14\BS/C-\D/\SU/9\BS/-THC. For I.V. administration, radiolabeled \D/\SU/9\BS/-THC (10 \mu/Ci; total \D/\SU/9\BS/-THC, 0.5 mg.) was prepared by aseptic techniques and dissolved in absolute alcohol for parenteral administration. For oral administration, \SU/14\BS/C-\D/\SU/9\BS/-THC (10 \mu/Ci) was diluted with a pharmacologic dose of nonradiolabeled \D/\SU/9\BS/-THC (0.3 mg./kg.) and added to cherry syrup \IT/USP \OK/to disguise its unpleasant taste. In the studies in which the drug was administered by inhalation, \SU/14\BS/C-\D/\SU/9\BS/-THC (10 \mu/Ci) was diluted with an alcoholic solution containing a pharmacologic dose of nonradiolabeled \D/\SU/9\BS/-THC (10 mg.). The final solution was divided into 2 equal portions and added throughout the length of 2 placebo-marihuana cigarettes up to a point delineated by an inked spot. Over 90% of the dose was absorbed after oral administration; the psychologic effects and plasma levels of metabolites of \D/\SU/9\BS/-THC peaked at 3 hours. After inhalation, the peak psychologic #OQ#OQhigh'' ranged from 10 to 140 minutes (average peak #OQ#OQhigh'' of 70 minutes), correlating well with the peak plasma levels of metabolites of \D/\SU/9\BS/-THC. The percentage of administered radioactive dose excreted in urine during the first day was similar after oral and I.V. routes, but the proportion of radioactivity recovered from feces (7 days) exceeded that in the one-day urine output. The fact that the psychologic effects in response to pharmacologic doses of ingested or inhaled \SU/14\BS/C-\D/\SU/9\BS/-THC were temporally correlated with plasma levels of the metabolites of the drug supports the hypothesis that these metabolites are active compounds.
KW - Tetrahydrocannabinol--effects-;
KW - Cannabis--derivatives-;
KW - Blood levels--tetrahydrocannabinol--correlation, to psychologic effects, in cannabis smokers, various routes of administration;
KW - Metabolism--tetrahydrocannabinol--blood levels, correlation, to psychologic effects, in cannabis smokers, various routes of administration;
KW - Drug administration--tetrahydrocannabinol--routes, in cannabis smokers, correlation of psychologic effects to blood levels;
KW - Excretion--tetrahydrocannabinol--in cannabis smokers, various routes of administration;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - TESH, ROBERT B.
AU - CHANIOTIS, BYRON N.
AU - JOHNSON, KARL M.
T1 - Vesicular Stomatitis Virus (Indiana Serotype): Transovarial Transmission by Phlebotomine Sandflies.
JO - Science
JF - Science
Y1 - 1972/03/31/
VL - 175
IS - 4029
M3 - Article
SP - 1477
EP - 1479
SN - 00368075
AB - Transovarial transmission of vesicular stomatitis virus (Indiana sero-type) by experimentally infected Lutzomyia trapidoi and Lutzomyia ylephiletrix to their progeny was demonstrated. Virus was recovered from all developmental stages; mean virus titers from egg to first generation adult showed a four-log increase, indicating that virus multiplication occurred during development of the sandflies. Virus titers in first generation adult females were comparable to those found in their parents. These infected female sandflies transmitted vesicular stoma titus virus Indiana by bite to susceptible animals and transmitted the virus transovarially to their offspring (second generation). Results demonstrate a possible mechanism for transmission and maintenance of this virus in nature without a vertebrate (heat) host reservoir. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160069; TESH, ROBERT B. 1; CHANIOTIS, BYRON N. 1; JOHNSON, KARL M. 1; Affiliations: 1: U.S. Public Health Service, National Institute of Allergy and infectious Diseases, Middle America Research Unit, Balboa Heights, Canal Zone; Issue Info: 3/31/1972, Vol. 175 Issue 4029, p1477; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SIMS, K. L.
AU - WEITSEN, H. A.
AU - BLOOM, F. E.
T1 - GABA Catabolism: Localization of Succinic Semialdehyde Dehydrogenase in Brain Motor and Sensory Nuclei.
JO - Science
JF - Science
Y1 - 1972/03/31/
VL - 175
IS - 4029
M3 - Article
SP - 1479
EP - 1480
SN - 00368075
AB - The localization of brain succinic semialdehyde dehydrogenase, a specific gamma-aminobutyric acid degradative enzyme, could potentially yield valuable information concerning the function of the enzyme. Application of a new histochemical technique for this enzyme has revealed characteristic patterns of neuronal staining that are contsistent within embryologically and functionally similar nuclei of ihe brainstem of the rat. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160070; SIMS, K. L. 1; WEITSEN, H. A. 1; BLOOM, F. E. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/31/1972, Vol. 175 Issue 4029, p1479; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hiranaka, P. K.;
AU - Frazier, A. G.;
AU - Gallelli, J. F.;
T1 - Stability of sodium ampicillin in aqueous solutions
CT - Stability of sodium ampicillin in aqueous solutions
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1972/04/01/
VL - 29
IS - Apr
SP - 321
EP - 322
SN - 00029289
AD - Pharmacy Department, The Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-2422; Language: English; Chemical Name: Ampicillin--69-53-4; Therapeutic Class: (8:12); AHFS Class: Antibiotics ampicillin; References: 4; Journal Coden: AJHPA9; Section Heading: Drug Stability
N2 - A stability study of sodium ampicillin in aqueous solutions was carried out in order to determine the effects of various concentrations on the activity of the antibiotic with time. The need for such specific data is essential because the stability of the drug is not only very much dependent on its vehicle, \IT/p\OK/H and temperature, but also on its concentration. Sodium ampicillin was studied at various concentrations (0.5, 1, 1.5, 2, 3 and 4 g./100 ml.) in 5% Dextrose Injection, U.S.P., and Sodium Chloride Injection, U.S.P., at 25 and 5\DG/C. Each sample solution was colorimetrically assayed and its \IT/p\OK/H recorded for one week. Results indicated that the stability of the drug is definitely concentration dependent, especially in sodium chloride injection where the lower concentrations were more stable (94% potency for a 0.5 g./100 ml. solution versus 85% potency for a 4.0 g./100 ml. solution after 24 hours at 25\DG/C.). All solutions at 5\DG/C. in Sodium Chloride Injection, U.S.P., were stable for 72 hours with the lower concentrations being more stable. A 5% Dextrose Injection, U.S.P., should not be used as a vehicle for sodium ampicillin, and if it is used, one should be aware that the solution is stable only for 4 hours at 5\DG/C. and less than 4 hours at 25\DG/C.
KW - Ampicillin--sodium-;
KW - Antibiotics--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
KW - Stability--ampicillin--sodium, in aqueous solutions, effects of concentration;
KW - Additives--injections--ampicillin, sodium, stability, in aqueous solutions, effects of concentration;
KW - Injections--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
KW - Concentration--effects--on stability of sodium ampicillin in aqueous solutions;
KW - Vehicles--ampicillin--sodium, stability, in aqueous solutions, effects of concentration;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Smiley, Jane
AU - Eyres, Sandra
AU - Roberts, Doris E.
T1 - Maternal and Infant Health and Their Associated Factors in an Inner City Population.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/04//
VL - 62
IS - 4
M3 - Article
SP - 476
EP - 482
PB - American Public Health Association
SN - 00900036
AB - This study identifies characteristics of infants and their families which may predict infant illness and failure to use preventive care following delivery. These characteristics are employed to develop a predictive model which may be further tested for usefulness. The need for attention to certain mothers is stressed, as are also the implications for public health nursing service. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Infant diseases
KW - Nursing services
KW - Nurse & patient
KW - Medical care
KW - Health education
KW - Preventive medicine
N1 - Accession Number: 24294089; Smiley, Jane 1; Eyres, Sandra 2; Roberts, Doris E. 3; Affiliations: 1: Maternal and Child Health Consultant, VNA of Detroit; 2: Nurse Consultant in Research, Nursing Practice Branch, Division of Nursing, National Institutes of Health; 3: Chief, Nursing Practice Branch, Division of Nursing, National Institutes of Health; Issue Info: Apr1972, Vol. 62 Issue 4, p476; Thesaurus Term: Public health; Subject Term: Infant diseases; Subject Term: Nursing services; Subject Term: Nurse & patient; Subject Term: Medical care; Subject Term: Health education; Subject Term: Preventive medicine; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Basco, Dolores
AU - Eyres, Sandra
AU - Glasser, Jay H.
AU - Roberts, Doris E.
T1 - Epidemiologic Analysis in School Populations as a Basis for Change in School-Nursing Practice -- Report of the Second Phase of a Longitudinal Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/04//
VL - 62
IS - 4
M3 - Article
SP - 491
EP - 497
PB - American Public Health Association
SN - 00900036
AB - A report is presented on the second phase of a study intended to elucidate factors that influence the health status and social functioning of school populations, Implications of the findings for school health nursing are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - School nursing
KW - School health services
KW - Medical care
KW - Pediatrics
KW - Social functions
KW - Public health personnel
N1 - Accession Number: 24294091; Basco, Dolores 1; Eyres, Sandra 1; Glasser, Jay H. 2; Roberts, Doris E. 3; Affiliations: 1: Nurse Consultants, Nursing Practice Branch, Division of Nursing, Bureau of Health Manpower Education, National Institutes of Health, HEW; 2: Associate Professor of Biostatistics, University of Texas, Houston; 3: Chief, Nursing Practice Branch, Division of Nursing, Bureau of Health Manpower Education, National Institutes of Health, HEW; Issue Info: Apr1972, Vol. 62 Issue 4, p491; Subject Term: School nursing; Subject Term: School health services; Subject Term: Medical care; Subject Term: Pediatrics; Subject Term: Social functions; Subject Term: Public health personnel; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Li, Frederick P.
AU - Schlief, Nyuk Yoong
AU - Chang, Caroline J.
AU - Gaw, Albert C.
T1 - Health Care for the Chinese Community in Boston.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/04//
VL - 62
IS - 4
M3 - Article
SP - 536
EP - 539
PB - American Public Health Association
SN - 00900036
AB - Poor health and low living standards prevail in Chinese-American communities. This report discusses some social and cultural origins of health needs among Chinese-Americans and describes the role of community participation in health programming for one Chinese community, the Chinatown of Boston. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Medical care
KW - Health planning
KW - Health promotion
KW - Socioeconomic factors
KW - United States
N1 - Accession Number: 24294098; Li, Frederick P. 1,2; Schlief, Nyuk Yoong 1,3; Chang, Caroline J. 1,4; Gaw, Albert C. 1,5; Affiliations: 1: Members of the Chinese Community Health Task Force of Boston, Mass; 2: Research Associate, Epidemiology Branch, National Cancer Institute, Field Station, 35 Binney Street, Boston, Mass. 02715; 3: Health Educator, Boston Tuberculosis and Respiratory Disease Association, Little City Hall, Chinatown, Boston; 4: Director, Little City Hall, Chinatown, Boston; 5: Assistant Professor of Psychiatry, Tufts-New England Medical Center; Issue Info: Apr1972, Vol. 62 Issue 4, p536; Thesaurus Term: Public health; Subject Term: Medical care; Subject Term: Health planning; Subject Term: Health promotion; Subject Term: Socioeconomic factors; Subject: United States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Smith, J. W.;
AU - Utz, J. P.;
T1 - Progressive disseminated histoplasmosis. A prospective study of 26 patients
CT - Progressive disseminated histoplasmosis. A prospective study of 26 patients
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/04/01/
VL - 76
IS - Apr
SP - 557
EP - 565
SN - 00034819
AD - reprints: Infectious Disease Section, Veterans Administration Hospital, 4500 South Lancaster Road, Dallas, Texas 75216
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 9-4185; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 51; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The clinical, laboratory, and histopathologic features of progressive disseminated histoplasmosis in 26 patients were studied prospectively. Amphotericin B was an effective agent in most patients, but relapses of infection occurred in half of those with favorable response.
KW - Amphotericin B--histoplasmosis-;
KW - Antibiotics, antifungal--amphotericin B--histoplasmosis, progressive disseminated, therapy, in patients;
KW - Histoplasmosis--progressive disseminated--prospective study of patients, including value of amphotericin B therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Steinberg, A. D.;
AU - Plotz, P. H.;
AU - Wolff, S. M.;
AU - Wong, V. G.;
AU - Agus, S. G.;
AU - \ET/;
T1 - Cytotoxic drugs in treatment of nonmalignant diseases
CT - Cytotoxic drugs in treatment of nonmalignant diseases
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/04/01/
VL - 76
IS - Apr
SP - 619
EP - 642
SN - 00034819
AD - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-0098; Language: English; References: 288; Publication Type: NIH Conference; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - The basis for using cytotoxic drugs in inflammatory diseases of uncertain cause is their immunosuppressive properties. These drugs interrupt nucleic acid and protein synthesis, thereby inhibiting various immune responses at different stages. Specific inhibition of an immune response is possible through drug-induced tolerance. Many of the agents have anti-inflammatory properties that may be a major factor in their efficacy. In short-term controlled trials, both cyclophosphamide and azathioprine have been useful in treatment of rheumatoid arthritis and systemic lupus erythematosus, cyclophosphamide in nephrosis, and methotrexate and azathioprine in psoriasis and psoriatic arthritis. Azathioprine was ineffective in iridocyclitis, nephritis, nephrosis, Crohn's disease, chronic hepatitis, and asthma. Cytotoxic drugs may increase the risk of infection, predispose to malignancy, and increase mutations in offspring. Specific side effects include hemorrhagic cystitis from cyclophosphamide, cirrhosis from methotrexate, and altered germ cell production by alkylating agents. Only long-term controlled trials, not uncontrolled reports or positive short-term controlled trials, will justify widespread clinical use of these drugs in inflammatory diseases.
KW - Antineoplastic agents--therapy--of nonmalignant diseases, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - STETTEN JR., DEWITT
T1 - Letters.
JO - Science
JF - Science
Y1 - 1972/04/07/
VL - 176
IS - 4030
M3 - Article
SP - 8
EP - 8
SN - 00368075
N1 - Accession Number: 87562569; STETTEN JR., DEWITT 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 4/7/1972, Vol. 176 Issue 4030, p8; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Frank, M. M.;
AU - Sergent, J. S.;
AU - Kane, M. A.;
AU - Alling, D. W.;
T1 - Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: double-blind study
CT - Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: double-blind study
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/04/13/
VL - 286
IS - Apr 13
SP - 808
EP - 812
SN - 00284793
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 11N104, Building 10, Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 9-4183; Language: English; Chemical Name: Aminocaproic acid--60-32-2; Therapeutic Class: (20:12.16); AHFS Class: Hemostatics aminocaproic acid; References: 35; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Five patients with hereditary angioneurotic edema were treated with a sequence of courses of epsilon aminocaproic acid (EACA) or placebo in a double-blind study. Attacks of edema were significantly less frequent during administration of EACA in 4 patients. The principal adverse side effects of EACA\M/muscle pain and weakness, accompanied by elevations in the serum enzymes creatine phosphokinase and aldolase\M/were usually observed when the dose of drug exceeded 20 g./day, but disappeared when the drug was discontinued or the dosage was lowered. After completion of the study, patients had their dosage gradually lowered and have been maintained on 7 to 10 g. of EACA per day in 4 divided doses. All patients except one continued to do well on this dosage schedule.
KW - Aminocaproic acid--edema-;
KW - Hemostatics--aminocaproic acid--edema, angioneurotic, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mulvihill, John J.
T1 - Congenital and Genetic Disease in Domestic Animals.
JO - Science
JF - Science
Y1 - 1972/04/14/
VL - 176
IS - 4031
M3 - Article
SP - 132
EP - 137
SN - 00368075
N1 - Accession Number: 85160088; Mulvihill, John J. 1; Affiliations: 1: Staff Associate, Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p132; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOPIN, IRWIN J.
T1 - Neurochemistry.
JO - Science
JF - Science
Y1 - 1972/04/14/
VL - 176
IS - 4031
M3 - Article
SP - 156
EP - 156
SN - 00368075
N1 - Accession Number: 85160099; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p156; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOSLOW, S. H.
AU - CATTABENI, F.
AU - COSTA, E.
T1 - Norepinephrine and Dopamine: Assay by Mass Fragmentography in the Picomole Range.
JO - Science
JF - Science
Y1 - 1972/04/14/
VL - 176
IS - 4031
M3 - Article
SP - 177
EP - 180
SN - 00368075
AB - Gas chromatography-mass spectrometry makes possible the simultaneous measurement of norepinephrine and dopamine in concentrations of 0.1- milligram tissue samples. Specificity of the assay is confirmed both by the retention time of the compound and by the mass to charge ratio of the fragments recorded. The sensitivity is of the order of 0.5 picomole, and linearity of the response is maintained up to at least 200 picomoles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160112; KOSLOW, S. H. 1; CATTABENI, F. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 4/14/1972, Vol. 176 Issue 4031, p177; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FRIEDLAENDER, MITCHELL H.
AU - BAER, HAROLD
T1 - lmmunologic Tolerance: Role of the Regional Lymph Node.
JO - Science
JF - Science
Y1 - 1972/04/21/
VL - 176
IS - 4032
M3 - Article
SP - 312
EP - 314
SN - 00368075
AB - Dansyl chloride, a skin setnsitizer when injected in complete Freund's adjuvant, induced marked tolerance and no sensitization when applied to the intact skin of guinea pigs. Application of this chemical to alymphatic skin islands failed to induce tolerance or sensitization. Lymnphatic connections between skin and regional lymph nodes were essential for the developmnent of ismmunologic tolerance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160165; FRIEDLAENDER, MITCHELL H. 1; BAER, HAROLD 1; Affiliations: 1: Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/21/1972, Vol. 176 Issue 4032, p312; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DALTON, ALBERT J.
AU - STEWART, SARAH E.
T1 - Intracisternal A Particles and C Particles.
JO - Science
JF - Science
Y1 - 1972/04/21/
VL - 176
IS - 4032
M3 - Article
SP - 319
EP - 319
SN - 00368075
N1 - Accession Number: 85160169; DALTON, ALBERT J. 1,2; STEWART, SARAH E. 1,2; Affiliations: 1: Office, Associate Scientific Director, Viral Oncology, National Cancer Institute, Bethesda, Maryland 20014; 2: Pathology Department, Georgetown University Medical School, Washington, D.C. 20007; Issue Info: 4/21/1972, Vol. 176 Issue 4032, p319; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LANCASTER, F. WILFRID
AU - SCHNEIDER, JOHN H.
T1 - Selective Dissemination.
JO - Science
JF - Science
Y1 - 1972/04/28/
VL - 176
IS - 4033
M3 - Article
SP - 434
EP - 437
SN - 00368075
N1 - Accession Number: 85160212; LANCASTER, F. WILFRID 1; SCHNEIDER, JOHN H. 2; Affiliations: 1: Graduate School of Library Science, University of Illinois, Urbana 61801; 2: Scientific and Technical Information Office, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/28/1972, Vol. 176 Issue 4033, p434; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Cargille, Charles M.
AU - Sager, Martha C.
T1 - Proposal for a World Data Bank.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/05//
VL - 62
IS - 5
M3 - Letter
SP - 626
EP - 626
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article about mass computer storage systems for information search and retrieval capabilities published in the previous issue.
KW - Letters to the editor
KW - Computer storage devices
N1 - Accession Number: 24294122; Cargille, Charles M. 1; Sager, Martha C. 2; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, Md. 20014; 2: American University, Washington, D.C.; Issue Info: May1972, Vol. 62 Issue 5, p626; Subject Term: Letters to the editor; Subject Term: Computer storage devices; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 334112 Computer Storage Device Manufacturing; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tillack, Warner S.
AU - Tyler Jr., Carl W.
AU - Paquette, Rick
AU - Jones, Phillip H.
T1 - A Study of Premarital Pregnancy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/05//
VL - 62
IS - 5
M3 - Article
SP - 676
EP - 679
PB - American Public Health Association
SN - 00900036
AB - A study of premarital pregnancy in all women under 30 living in a single county who first married in 1968 is reported. The proportion of brides pregnant at marriage declined with higher age at marriage and with increased education. During the year of study the out-of-wedlock births were only about one-third of the total premarital pregnancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Social surveys
KW - Unwanted pregnancy
KW - Single mothers
KW - Single parents
KW - Pregnant women
KW - Prenatal care
KW - First pregnancy
KW - Prenatal influences
KW - Maternal health services
N1 - Accession Number: 24294139; Tillack, Warner S. 1; Tyler Jr., Carl W. 2; Paquette, Rick 3; Jones, Phillip H. 4; Affiliations: 1: Demographer, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda. Maryland; 2: Chief, Family Planning Evaluation Activity, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda. Maryland; 3: Research Analyst, Management Information Section, Division of Health, Department of Social and Health Services, Olympia, Washington 98501; 4: District Health Officer, Bellingham and Whatcom District, Department of Public Health, 509 Girard St., Bellingham, Washington 98225; Issue Info: May1972, Vol. 62 Issue 5, p676; Subject Term: Social surveys; Subject Term: Unwanted pregnancy; Subject Term: Single mothers; Subject Term: Single parents; Subject Term: Pregnant women; Subject Term: Prenatal care; Subject Term: First pregnancy; Subject Term: Prenatal influences; Subject Term: Maternal health services; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Friedewald, W. T.;
AU - Halperin, M.;
T1 - Clofibrate in ischemic heart disease
CT - Clofibrate in ischemic heart disease
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/05/01/
VL - 76
IS - May
SP - 821
EP - 823
SN - 00034819
AD - Biometrics Research Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 10-0270; Language: English; Chemical Name: Clofibrate--637-07-0; Therapeutic Class: (24:06); AHFS Class: Antilipemic agents clofibrate (24:04); AHFS Class: Cardiac drugs clofibrate; References: 6; Publication Type: Editorials; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2 - Two recent studies on clofibrate are discussed. Although there is some indication in both trials of benefit from clofibrate, the authors raise several points about the study and suggest the need for further verification.
KW - Clofibrate--therapy-;
KW - Antilipemic agents--clofibrate--therapy, in ischemic heart disease, discussion;
KW - Cardiac drugs--clofibrate--therapy, in ischemic heart disease, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gelfand, M. C.;
AU - Steinberg, A. D.;
AU - Nagle, R.;
AU - Knepshield, J. H.;
T1 - Therapeutic studies in NZB/W mice. I. Synergy of azathioprine cyclophosphamide, and methylprednisolone in combination
CT - Therapeutic studies in NZB/W mice. I. Synergy of azathioprine cyclophosphamide, and methylprednisolone in combination
JO - Arthritis and Rheumatism (USA)
JF - Arthritis and Rheumatism (USA)
Y1 - 1972/05/01/
VL - 15
IS - May-Jun
SP - 239
EP - 246
SN - 00043591
AD - Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland 20012) (Reprints: Department of Nephrology, Walter Reed General Hospital, Box 216, Washington, D.C. 20012
N1 - Accession Number: 10-1067; Language: English; Chemical Name: Azathioprine--446-86-6 Cyclophosphamide--6055-19-2 Methylprednisolone--83-43-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents azathioprine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (68:04); AHFS Class: Steroids, cortico- methylprednisolone; Journal Coden: ARHEAW; Section Heading: Drug Evaluations
N2 - The study compares different immunosuppressive regimens of azathioprine, cyclophosphamide, and methylprednisolone in the treatment of lupus-like nephritis of NZB/W mice. A group of 5-month-old female NZB/W mice were given azathioprine, cyclophosphamide, and methylprednisolone in all one-, two-, and three-drug regimens, each drug in the relatively low dose of 1.5 mg./kg./day. Treatment for 3 months with one or 2 drugs resulted in modest suppression of lupus-like nephritis. Mice receiving all 3 drugs had significantly less proteinuria, lower titers of anti-DNA antibody and less severe, histologically evident renal involvement than mice treated with one or 2 drugs. Survival at one year was 10% for untreated controls, 44% for one-drug treated, 37% for two-drug treated, and 86% for three-drug treated mice. The survival for the three-drug regimen was significantly longer than any other group (P[0.01).] The beneficial effects of triple drug therapy were attained without increased toxicity. Based on these results, a controlled evaluation of triple drug therapy in human systemic lupus erythematosus appears warranted.
KW - Azathioprine--alone and with cyclophosphamide and methylprednisolone-;
KW - Cyclophosphamide--alone and with azathioprine and methylprednisolone-;
KW - Methylprednisolone--alone and with azathioprine and cyclophosphamide-;
KW - Immunosuppressive agents--azathioprine--alone and with cyclophosphamide and methylprednisolone, nephritis, lupus-like, therapy, in mice;
KW - Antineoplastic agents--cyclophosphamide--alone and with azathioprine and methylprednisolone, nephritis, lupus-like, therapy, in mice;
KW - Steroids, cortico---methylprednisolone--alone and with azathioprine and cyclophosphamide, nephritis, lupus-like, therapy, in mice;
KW - Combined therapy--antineoplastic agents--nephritis, lupus-like, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Huffman, D. H.;
AU - Bachur, N. R.;
T1 - Daunorubicin metabolism in acute myelocytic leukemia
CT - Daunorubicin metabolism in acute myelocytic leukemia
JO - Blood
JF - Blood
Y1 - 1972/05/01/
VL - 39
IS - May
SP - 637
EP - 643
AD - Biochemistry Section, Laboratory of Pharmacology, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 12-2853; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 24; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Jimmie L. Hall
N2 - The conversion of daunorubicin (daunomycin) to its active metabolite daunorubicinol by means of daunorubicin reductase in leukemia patients is reported.
KW - Daunomycin--metabolism-;
KW - Metabolism--daunomycin--conversion, enzyme, to daunorubicinol, in leukemia patients;
KW - Antineoplastic agents--daunomycin--metabolism, enzyme conversion to daunorubicinol, in leukemia patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06118-013
AN - 2006-06118-013
AU - Plaut, Thomas F. A.
T1 - Is the Flask Old-Fashioned?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1972/05//
VL - 17
IS - 5
SP - 277
EP - 278
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06118-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Plaut, Thomas F. A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: College Students; Drinking Behavior; Drug Education; Social Issues. Classification: Drug & Alcohol Usage (Legal) (2990); Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Reviewed Item: Maddox, George L. (Ed). The Domesticated Drug: Drinking among Collegians=New Haven, Conn.: College and University Press, 1970. Pp. 479. $9.00 cloth; $4.50 paper; 1970. Page Count: 2. Issue Publication Date: May, 1972.
AB - Reviews the book, The Domesticated Drug: Drinking among Collegians edited by George L. Maddox (1970). This collection of articles--and its review--unfortunately has been a long time in getting to the reader. The volume is sponsored by the Society for the Study of Social Problems. A number of the articles present data on sociological (and other) characteristics of college drinkers and abstainers. The final section of the volume focuses on issues related to alcohol education on campuses and on the regulation of collegiate drinking behavior. Drinking among college students is likely to be very different when the full effect of these new national attitudes has been felt and when drug use patterns among young people have stabilized. This volume is of particular interest because it provides an excellent historical and conceptual summary of sociological and psychological work in the years prior to the period of major change which occurred in the latter half of the 196O's. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - collegiate drinking behavior
KW - domesticated drugs
KW - social problems
KW - college drinkers
KW - abstainers
KW - 1972
KW - College Students
KW - Drinking Behavior
KW - Drug Education
KW - Social Issues
KW - 1972
U2 - Maddox, George L. (Ed). (1970); The Domesticated Drug: Drinking among Collegians; New Haven, Conn.: College and University Press, 1970. Pp. 479. $9.00 cloth; $4.50 paper
DO - 10.1037/0010927
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - ROBERT, MARJORIE S.
AU - SMITH, R. GRAHAM
AU - GALLO, ROBERT C.
AU - SARIN, PREM S.
AU - ABRELL, JOHN W.
T1 - Viral and Cellular DNA Polymerase: Comparison of Activities with Synthetic and Natural RNA Templates.
JO - Science
JF - Science
Y1 - 1972/05/19/
VL - 176
IS - 4036
M3 - Article
SP - 798
EP - 800
SN - 00368075
AB - Two DNA polymerases purified from normal human lymphocytes are distinguishable from the viral reverse transcriptases of avian myeloblastosis virus and Mason-Pfizer monkey virus by their relative affinity for select templates. In this respect, the activity of the two normal human lymphocyte polymerases closely resembles the activity of Escherichia coli DNA polymerase 1. The viral and cellular DNA polymerases are equally active with the nonspecific template, poly(rA) poly(dT). Criteria for distinguishing the activity of viral reverse transcriptase are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160285; ROBERT, MARJORIE S. 1; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; SARIN, PREM S. 2; ABRELL, JOHN W. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; 2: Bionetics Research Laboratories, Bethesda, Maryland 20014; Issue Info: 5/19/1972, Vol. 176 Issue 4036, p798; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAYFLICK, LEONARD
AU - PETRICCIANI, JOHN C.
AU - Hopps, HOPE E.
AU - LORENZ, DOUGLAS E.
T1 - Human Virus Vaccines: Why Monkey Cells?
JO - Science
JF - Science
Y1 - 1972/05/19/
VL - 176
IS - 4036
M3 - Article
SP - 813
EP - 814
SN - 00368075
N1 - Accession Number: 85160293; HAYFLICK, LEONARD 1; PETRICCIANI, JOHN C. 2; Hopps, HOPE E. 2; LORENZ, DOUGLAS E. 2; Affiliations: 1: Stanford University School of Medicine, Stanford, California; 2: Laboratory of Pathology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/19/1972, Vol. 176 Issue 4036, p813; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Aptekar, R. G.;
AU - Decker, J. L.;
AU - Steinberg, A. D.;
T1 - Exacerbation of SLE nephritis after cyclophosphamide withdrawal
CT - Exacerbation of SLE nephritis after cyclophosphamide withdrawal
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/05/25/
VL - 286
IS - May 25
SP - 1159
EP - 1160
SN - 00284793
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 9-3564; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 2; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - It was suggested that caution be observed in withdrawing cyclophosphamide therapy in patients suffering from systemic lupus erythematosus (SLE) with nephritis. Two cases are cited in which adverse consequences followed cyclophosphamide withdrawal. Both patients died of uremia.
KW - Cyclophosphamide--withdrawal-;
KW - Drugs, adverse reactions--cyclophosphamide--withdrawal, fatal uremia, in systemic lupus erythematosus patients;
KW - Antineoplastic agents--cyclophosphamide--withdrawal, adverse reactions, fatal uremia, in systemic lupus erythematosus patients;
KW - Drug administration--cyclophosphamide--withdrawal, adverse reactions, fatal uremia, in systemic lupus erythematosus patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - GALANTER, MARC `
AU - WYATT, RICHARD J.
AU - LEMBERGER, Louis
AU - WEINGARTNER, HERBERT
AU - VAUGHAN, TOM B.
AU - ROTH, WALTON T.
T1 - Effects on Humans of △9-Tetrahydrocannabinol Administered by Smoking.
JO - Science
JF - Science
Y1 - 1972/05/26/
VL - 176
IS - 4037
M3 - Article
SP - 934
EP - 936
SN - 00368075
AB - Twelve chronic marijuana users received △9-tetrahydrocannabinol by smoking. The magnitude of their pulse increment was highly correlated with their subjective experiences. Three! of the 12 subjects subsequently received △9z-tetrahydrocannabinol labeled with carbon-14; the time course of its concentration in plasma was highly correlated with the pulse increment. Subjective symptoms, however, appeared later and dissipated more slowly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160339; GALANTER, MARC ` 1; WYATT, RICHARD J. 1; LEMBERGER, Louis 1; WEINGARTNER, HERBERT 1; VAUGHAN, TOM B. 1; ROTH, WALTON T. 1; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 5/26/1972, Vol. 176 Issue 4037, p934; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Sato, F. F.;
T1 - Trials with cyclophosphamide in SLE (systemic lupus erythematosus)
CT - Trials with cyclophosphamide in SLE (systemic lupus erythematosus)
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 1972/06/01/
VL - 72
IS - Jun
SP - 1077
EP - 1079
SN - 0002936X
AD - Clinical Center, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 10-3292; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 5; Journal Coden: AJNUAK; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmie L. Hall
N2 - The nursing care of 2 systemic lupus erythematosus patients receiving cyclophosphamide in a trial study is described.
KW - Cyclophosphamide--lupus erythematosus-;
KW - Antineoplastic agents--cyclophosphamide--lupus erythematosus, therapy, nursing care, case reports;
KW - Nursing--cyclophosphamide--lupus erythematosus, therapy, and care, case reports;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Neva, F. A.;
T1 - Parasitic diseases of the GI tract in the United States
CT - Parasitic diseases of the GI tract in the United States
JO - Dis. Mon.
JF - Dis. Mon.
Y1 - 1972/06/01/
VL - Pages 1-44
IS - Jun
AD - National Institutes of Health, Clinical Parasitology Section, Laboratory of Clinical Investigation of the Institute of Allergy and Infectious Disease, Bethesda, Maryland 20014
N1 - Accession Number: 10-1323; Language: English; References: 47; Journal Coden: DIMOAN; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: George D. Hurlow
N2 - The reproductive cycle of parasites presents the basis for chemotherapy in parasitic diseases. The parasitic diseases include amebiasis, giardiasis, schistosomiasis, strongyloidiasis, tapeworm, ascariasis, trichuriasis, hookworm, and enterobiasis. Dosage, specificity and combination chemotherapy is discussed for the following drugs: metronidazole, chloroquine, emetine, quinacrine, stibophen, antimony dimercaptosuccinate, niridazole, hycanthone, thiabendazole, niclosamide, piperazine, hexylresorcinol, tetrachlorethylene, bephenium hydroxynaphthoate, piperazine citrate and pyrvinium pamoate.
KW - Anthelmintics--therapy--diseases, parasitic, GI tract, in humans;
KW - Schistosomicides--therapy--discussion, in humans;
KW - Dosage--anthelmintics--discussion, in humans;
KW - Antiprotozoals--therapy--discussion, in humans;
KW - Combined therapy--anthelmintics--discussion, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Carlson, Rae
T1 - Understanding Women: Implications for Personality Theory and Research.
JO - Journal of Social Issues
JF - Journal of Social Issues
Y1 - 1972/06//
VL - 28
IS - 2
M3 - Article
SP - 17
EP - 32
SN - 00224537
AB - Discusses the psychology of women.
KW - FEMALES
KW - PSYCHOLOGY
KW - PERSONALITY
KW - TYPOLOGY (Psychology)
KW - FEMININITY
KW - EMPIRICAL research
KW - WOMEN
KW - DECISION MAKING AND COMMUNICATIONS
N1 - Accession Number: 16486944; Carlson, Rae 1; Affiliations: 1 : National Institute of Mental Health.; Source Info: Jun1972, Vol. 28 Issue 2, p17; Historical Period: 1972; Subject Term: FEMALES; Subject Term: PSYCHOLOGY; Subject Term: PERSONALITY; Subject Term: TYPOLOGY (Psychology); Subject Term: FEMININITY; Subject Term: EMPIRICAL research; Subject Term: WOMEN; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - FISCHINGER, P. J.
AU - NOMURA, S.
AU - PEEBLES, P. T.
AU - HAAPALA, D. K.
AU - BASSIN, R. H.
T1 - Reversion of Murine Sarcoma Virus Transformed Mouse Cells: Variants without a Rescuable Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1972/06/02/
VL - 176
IS - 4038
M3 - Article
SP - 1033
EP - 1035
SN - 00368075
AB - Murine sarcoma virus transformed mouse 3T3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia viruts, spontaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. The revertants support leukemia virus growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release RNA-dependent DNA polymerase activity. Because revertants could be obtained with high frequency from progeny of single transformed cells, each cell that contains the sarcoma virus genome seems to have the capacity to suppress or elimtinate an RNA tumor virus native to its species of origin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158051; FISCHINGER, P. J. 1; NOMURA, S. 1; PEEBLES, P. T. 1; HAAPALA, D. K. 1; BASSIN, R. H. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 2/1972, Vol. 176 Issue 4038, p1033; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - NICOLL, ROGER A.
T1 - Gamma-Amiobutyric Acid: Role in Primary Afferent Depolarization.
JO - Science
JF - Science
Y1 - 1972/06/02/
VL - 176
IS - 4038
M3 - Article
SP - 1043
EP - 1045
SN - 00368075
AB - The effects of putative transmitters on the primary afferent terminals were studied in the magnesium-treated, isolated spinal cord of the frog. Gammaaminobutyric acid and glutamic acid reversibly depolarized primary afferent terminals and increased their excitability, whereas glycine produced weak and variable effects. Bicuculline and picrotoxin, which reduce primary afferent depolarization, reversibly antagonized the gamma-aminobutyric acid-mediated responses but had little effect on those produced by either glutamic acid or glycine. The glutamic acid- and the gamma-aminobutyric acid-induced depolarizations remained in the absence of external chloride but disappeared in the absence of external sodium. These results support the hypotheses that gamma-aminobutyric acid is the transmitter mediating the synaptic depolarization of primary afferent terminals and that sodium is the predominant ion involved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158056; BARKER, JEFFERY L. 1; NICOLL, ROGER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 6/ 2/1972, Vol. 176 Issue 4038, p1043; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RAPOPORT, STANLEY I.
AU - BACHMAN, DAVID S.
AU - THOMPSON, HARRY K.
T1 - Chronic Effects of Osmotic Opening of the Blood-Brain Barrier in the Monkey.
JO - Science
JF - Science
Y1 - 1972/06/16/
VL - 176
IS - 4040
M3 - Article
SP - 1243
EP - 1244
SN - 00368075
AB - In the monkey, the blood-brain barrier and the blood-aqueous and blood-vitreous barriers of the eye can be opened by internal carotid perfusion of solutions of 2 molar urea in a way compatible with survival and, in some few cases, without detectable neurological deficits. Urea presumably acts by osmotically shrinking the endothelial cells of the cerebrovascular vessels and opening their tight junctions. The high incidence of brain necrosis with neurological sequelae after perfusion of urea by the present technique precludes the use of osmotic opening of the blood-brain barrier for pharmacotherapy at this time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87438410; RAPOPORT, STANLEY I. 1; BACHMAN, DAVID S. 2; THOMPSON, HARRY K. 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20-014; 2: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health; 3: Laboratory of Neurophysiology, National Institute of Mental Health; Issue Info: 6/16/1972, Vol. 176 Issue 4040, p1243; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Cramer, H.;
AU - Goodwin, F. K.;
AU - Post, R. M.;
AU - Bunney, W. E., Jr.;
T1 - Effects of probenecid and exercise on cerebrospinal fluid cyclic AMP in affective illness
CT - Effects of probenecid and exercise on cerebrospinal fluid cyclic AMP in affective illness
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1972/06/17/
VL - 1
IS - Jun 17
SP - 1346
EP - 1347
SN - 00237507
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 9-4475; Language: English; Chemical Name: Probenecid--57-66-9; Therapeutic Class: (40:40); AHFS Class: Uricosuric agents probenecid; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Administration of probenecid by lumbar puncture to 16 manic and depressed patients resulted in increases in cyclic adenosine 3\PR/,5\PR/-monophosphate (AMP) levels.
KW - Probenecid--effects-;
KW - Uricosuric agents--probenecid--effects, increase, cyclic adenosine 3\PR/,5\PR/-monophosphate levels, in affectively ill patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - HIRSCHBERG, ERICH
AU - JOSEPH FU, S. C.
AU - FRISELL, WILHELM R.
AU - FARBER, EMMANUEL
AU - POTTER, VAN R.
AU - RUSCH, HAROLD P.
AU - SAFFIOTTI, UMBERTO
AU - SHIMKIN, MICHAEL B.
AU - BRENNAN, MICHAEL J.
AU - NOWELL, PETER C.
AU - CREECH, HUGH J.
AU - TAYLOR, R. M.
AU - SCHABEL JR., F. M.
AU - FREI III, EMIL
AU - LEPAGE, G. A.
AU - WEINHOUSE, SIDNEY
AU - HALL, THOMAS C.
T1 - Newsgathering.
JO - Science
JF - Science
Y1 - 1972/06/23/
VL - 176
IS - 4041
M3 - Article
SP - 1288
EP - 1289
SN - 00368075
N1 - Accession Number: 85437480; HIRSCHBERG, ERICH 1; JOSEPH FU, S. C. 1; FRISELL, WILHELM R. 1; FARBER, EMMANUEL 2; POTTER, VAN R. 3; RUSCH, HAROLD P. 3; SAFFIOTTI, UMBERTO 4; SHIMKIN, MICHAEL B. 5; BRENNAN, MICHAEL J. 6; NOWELL, PETER C. 7; CREECH, HUGH J. 8; TAYLOR, R. M. 9; SCHABEL JR., F. M. 10; FREI III, EMIL 11; LEPAGE, G. A. 11; WEINHOUSE, SIDNEY 12; HALL, THOMAS C. 13; Affiliations: 1: College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103; 2: Temple University, Philadelphia, Pennsylvania 19122; 3: University of Wisconsin, Madison 53706; 4: National Cancer Institute, Bethesda, Maryland 20014; 5: University of California, San Diego, La Jolla 92037; 6: Michigan Cancer Foundation, Detroit 48201; 7: University of Pennsylvania, Philadelphia 19104; 8: Institute for Cancer Research, Philadelphia, Pennsylvania 19111; 9: National Cancer Institute of Canada, Toronto, Ontario; 10: Southern Research Institute, Birmingham, Alabama 35205; 11: M. D. Anderson Hospital, Houston, Texas 77025; 12: Fels Research Institute, Philadelphia, Pennsylvania 19140; 13: University of Rochester, Rochester, New York 14627; Issue Info: 6/23/1972, Vol. 176 Issue 4041, p1288; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOVEY, MARTIN M.
AU - BAK, ANTHONY F.
AU - CARPENTER, DAVID O.
T1 - Low Internal Conductivity of Aplysia Neuron Somata.
JO - Science
JF - Science
Y1 - 1972/06/23/
VL - 176
IS - 4041
M3 - Article
SP - 1329
EP - 1330
SN - 00368075
AB - The internal conductivity of Aplysia neuron somata was measured by passing constant current pulses across a calibrated four-electrode array. The intracellular medium -is less than one-tenth as conductive as seawater. The low conductivity probably results from structured cell water since ions are present in quantity and do not appear to be bound. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437502; HOVEY, MARTIN M. 1; BAK, ANTHONY F. 1; CARPENTER, DAVID O. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/23/1972, Vol. 176 Issue 4041, p1329; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOOKS, JOHN
AU - GIBBS JR., C. J.
AU - CHOPRA, H.
AU - LEWIS, M.
AU - GAJDUSEK, D. C.
T1 - Spontaneous Transformation of Human Brain Cells Grown in vitro and Description of Associated Virus Particles.
JO - Science
JF - Science
Y1 - 1972/06/30/
VL - 176
IS - 4042
M3 - Article
SP - 1420
EP - 1422
SN - 00368075
AB - A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158091; HOOKS, JOHN 1; GIBBS JR., C. J. 1; CHOPRA, H. 2; LEWIS, M. 1; GAJDUSEK, D. C. 1; Affiliations: 1: National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1420; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEVITAN, HERBERT
AU - BARKER, JEFFERY L.
T1 - Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability.
JO - Science
JF - Science
Y1 - 1972/06/30/
VL - 176
IS - 4042
M3 - Article
SP - 1423
EP - 1425
SN - 00368075
AB - Salicylate atnd beuizoate., antd their anlalogs, reversibly intcrease the membrane potetntial and conductance of idenitified molluscan neurons by increasitng potassium conductance and decreasing chloride condluctanice. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficienits and their pK vallues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158092; LEVITAN, HERBERT 1; BARKER, JEFFERY L. 1; Affiliations: 1: Behavioral-Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1423; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KONIVER, DEENA A.
AU - WISWESSER, WILLIAM J.
AU - USDIN, EARL
T1 - Wiswesser Line Notation: Simplified Techniques for Converting Chemical Structures to WLN.
JO - Science
JF - Science
Y1 - 1972/06/30/
VL - 176
IS - 4042
M3 - Article
SP - 1437
EP - 1439
SN - 00368075
AB - Techniques have been developed for the generation of Wiswesser Line Notations (WLN), which require knowledge neither of rules for manual conversion of structures to line notations nor of computer programmning. The desired WLN are obtained simply by drawing the structures of the compounds of interest on a tablet, which is linked to an appropriately programmned compuiter. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158099; KONIVER, DEENA A. 1; WISWESSER, WILLIAM J. 2; USDIN, EARL 3; Affiliations: 1: Division of Cotnputer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; 2: Vegetation Control Division, Edgewood Arsenal Chetnical Laboratory, Fort Detrick, Frederick, Maryland 21701; 3: Psychophartnacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852; Issue Info: 6/30/1972, Vol. 176 Issue 4042, p1437; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
AU - Murphy, D. L.;
AU - Dunner, D. L.;
AU - Bunney, W. E., Jr.;
T1 - Lithium response in unipolar versus bipolar depression
CT - Lithium response in unipolar versus bipolar depression
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1972/07/01/
VL - 129
IS - Jul
SP - 76
EP - 79
SN - 0002953X
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1265; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants lithium carbonate; References: 22; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Mary Ann Sullivan
N2 - The antidepressant effects of lithium carbonate were evaluated in a group of 52 depressed patients using a longitudinal double-blind design that involved alternating drug and placebo periods in the same patient. All patients were hospitalized on two 12-bed metabolic research units. Forty patients were assigned to the bipolar group and 12 to the unipolar group on the basis of presence (bipolar) or absence (unipolar) of a prior manic or hypomanic history. Lithium carbonate was administered in 300 mg. capsules for a duration of at least 2 weeks following a 6-day minimum placebo period. For the evaluation of response the mean depression ratings for the 4 days immediately prior to the administration of lithium were compared to the last 4 days on lithium. Of the 52 patients, 36 showed some improvement on lithium including 15 who had complete remission of symptoms. Virtually all of the antidepressant responses occurred in patients with a past history of mania or hypomania (the bipolar group).
KW - Lithium carbonate--antidepressants-;
KW - Antidepressants--lithium carbonate--evaluations, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - O'Brien, R. A.;
AU - Boullin, D. J.;
T1 - Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets
CT - Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1972/07/01/
VL - 21
IS - Jul 1
SP - 1817
EP - 1827
AD - Laboratory of Pre-Clinical Pharmacology, National Institute of Mental Health, St. Elizabeth's Hospital, Washington, D. C. 20032
N1 - Accession Number: 9-4224; Language: English; Chemical Name: Guanethidine--55-65-2 Debrisoquin--1131-64-2 Amiloride--2609-46-3 Guanidine--113-00-8; Therapeutic Class: (40:28); AHFS Class: Diuretics amiloride (24:08); AHFS Class: Hypotensive agents guanethidine (24:08); AHFS Class: Hypotensive agents debrisoquin; References: 32; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2 - Human platelets suspended in plasma or Krebs solution were incubated with radioactive guanethidine, debrisoquin, amiloride or guanidine and the platelet-bound radioactivity was measured. Guanethidine and debrisoquin were taken up by a saturable energy-dependent process inhibited by 5-hydroxytryptamine (5-HT), desipramine, amphetamine, cocaine and quinidine. Amiloride and guanidine entered by a nonsaturable mechanism not affected by metabolic inhibitors, 5-HT or drugs which interfere with the 5-HT transport process. It was suggested that guanethidine and debrisoquin probably utilize the 5-HT transport mechanism while amiloride and guanidine entered the cells by diffusion. It was concluded that although guanethidine and debrisoquin are taken up by platelets by an energy dependent system related to the 5-HT system, their storage sites are different. Amiloride enters platelets by diffusion and like guanethidine is firmly bound by the platelet, but not in the outer membrane. Storage of both drugs is largely intracellular involving more than one site, one of which may be the 5-HT stores.
KW - Guanethidine--body distribution-;
KW - Debrisoquin--body distribution-;
KW - Amiloride--body distribution-;
KW - Guanidine--body distribution-;
KW - Binding--guanethidine--accumulation, storage and release, by human platelets;
KW - Binding--debrisoquin--accumulation, storage and release, by human platelets;
KW - Binding--amiloride--accumulation, storage and release, by human platelets;
KW - Binding--guanidine--accumulation, storage and release, by human platelets;
KW - Diuretics--amiloride--accumulation, storage and release, by human platelets;
KW - Hypotensive agents--guanethidine--accumulation, storage and release, by human platelets;
KW - Hypotensive agents--debrisoquin--accumulation, storage and release, by human platelets;
KW - Metabolism--guanethidine--accumulation, storage and release, by human platelets;
KW - Metabolism--debrisoquin--accumulation, storage and release, by human platelets;
KW - Metabolism--amiloride--accumulation, storage and release, by human platelets;
KW - Metabolism--guanidine--accumulation, storage and release, by human platelets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Peters, C. J.
AU - Johnson, K. M.
T1 - SERUM IMMUNOGLOBULIN LEVELS IN AUSTRALIA ANTIGEN POSITIVE AND AUSTRALIA ANTIGEN NEGATIVE HEPATITIS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/07//
VL - 11
IS - 3
M3 - Article
SP - 381
EP - 391
PB - Wiley-Blackwell
SN - 00099104
AB - Ig levels were determined by radial immunodiffusion in uncomplicated cases of acute hepatitis with or without Australia antigenaemia. Initial sera from Australia antigen negative cases showed a striking elevation in IgM levels when compared to Australia antigen positive cases (6.5 versus 1.9 mg/ml). None of twenty-four Australia antigen positive cases exceeded 3 mg/ml IgM, and only 3/58 Australia antigen negative cases exhibited values below 3 mg/ml. initial sera from Australia antigen positive and Australia antigen negative subjects did not differ in concentration of IgG, IgA, or IgD. Serial determinations of IgG revealed a transient fall in patients with Australia antigen positive hepatitis, and a rise in Australia antigen negative cases. Asymptomatic, Australia antigen positive, Guaymi Indian subjects were compared to matched Australia antigen negative controls from the same indigenous group and no differences in the concentration of IgG, IgM, IgA or IgD were found, although elevations of IgG and IgM were common in both groups. No evidence of abnormal proteins was found when sera were tested by cellulose acetate electrophoresis or by immunoelectrophoresis versus immunoglobulin-specific anti- sera. Ultracentrifugal analysis failed to detect `7S' IgM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNODIFFUSION
KW - ANTIGENS
KW - IMMUNOGLOBULIN G
KW - ANTIGEN-antibody reactions
KW - IMMUNOELECTROPHORESIS
KW - ELECTROPHORESIS
N1 - Accession Number: 14545001; Peters, C. J. 1 Johnson, K. M. 1; Affiliation: 1: U.S. Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Middle America Research Unit, Box 2011, Balboa Heights, Canal Zone, Central America.; Source Info: Jul72, Vol. 11 Issue 3, p381; Subject Term: IMMUNODIFFUSION; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULIN G; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOELECTROPHORESIS; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
T1 - Immune Response in the Turtle (Chrysemys picta).
JO - Immunology
JF - Immunology
Y1 - 1972/07//
VL - 23
IS - 1
M3 - Article
SP - 45
EP - 52
PB - Wiley-Blackwell
SN - 00192805
AB - The immune response of painted turtles (Chrysemys picta) to four purified protein antigens was evaluated by radioimmunoelectrophoresis. Specific antibody production was consistently detected and antigen binding was related to four immunoglobulin (Ig) precipitin lines (called Igl, 2, 3, 4) in turtle serum. Antibody activity was detected first in the Ig1 or Ig2 and then later in the course of immunization in Ig3 and Ig4. Igl was about 19S in size, was not detectable after reduction and alkylation, and was the only Ig absent from turtle lymph. Ig3 and Ig4 were about 7S in size and Ig2 appeared slightly heavier by sucrose density gradient and Sephadex G-200 analysis. Haemagglutinins produced after primary inoculation were routinely sensitive to mild reduction and alkylation although antigen-binding capacity was still detectable. However, mercaptoethanol-resistant haemagglutinins were found in sera from turtles after booster injections of antigen. The electrophoretically slowest gamma globulin in turtle serum did not develop specific antigen binding capacity, but did bind Fe59 and presumably represents a transferrin-like protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - IMMUNOLOGY
KW - CHRYSEMYS
KW - TURTLES
KW - ANTIGEN-antibody reactions
KW - IMMUNOGLOBULINS
KW - HEMAGGLUTININ
N1 - Accession Number: 13378221; Coe, J.E. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Jul72, Vol. 23 Issue 1, p45; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: CHRYSEMYS; Subject Term: TURTLES; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOGLOBULINS; Subject Term: HEMAGGLUTININ; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whedon, C. Donald
T1 - MAGNITUDE OF PSORIASIS AS A DISEASE PROBLEM.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1972/07//
VL - 59
IS - 1
M3 - Article
SP - 2
EP - 2
SN - 0022202X
AB - This article focuses on a workshop on cell controls in psoriasis. There seems to be throughout the U.S. an increasing awareness of psoriasis and the feeling that there is a need to do more about it. This workshop is a significant and valuable part of an intensifying effort to learn more add to do more about this serious and important disease. The workshop will concentrate more closely on the fundamental aspects of cell biology and metabolism, hopefully eliciting information which will be the groundwork for future research leading to the control of this serious disease. Precise data on the current prevalence, disability and economic impact of psoriasis are not available.
KW - PSORIASIS
KW - CELL metabolism
KW - CYTOLOGY
KW - SKIN diseases
KW - CELLS
KW - UNITED States
N1 - Accession Number: 12625638; Whedon, C. Donald 1; Affiliation: 1: Director, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health.; Source Info: Jul72, Vol. 59 Issue 1, p2; Subject Term: PSORIASIS; Subject Term: CELL metabolism; Subject Term: CYTOLOGY; Subject Term: SKIN diseases; Subject Term: CELLS; Subject Term: UNITED States; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/1523-1747.ep12625638
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nigra, Thomas P.
AU - Friedland, Michael
AU - Martin, George R.
T1 - CONTROLS OF CONNECTIVE TISSUE SYNTHESIS: COLLAGEN METABOLISM.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1972/07//
VL - 59
IS - 1
M3 - Article
SP - 44
EP - 48
SN - 0022202X
AB - To meet their structural role, connective tissues must be stable and resistant to stress. This stability has often been confused with metabolic inertness, but in fact synthetic and degradative processes in connective tissue can occur rapidly even in mature animals. In addition to a number of physiological stimuli that provoke the remodeling of these tissues, marked alterations occur in a variety of disease processes. Since collagen is the major structural component of connective tissue, authors have focused their attention on the changes occurring in its metabolism.
KW - CONNECTIVE tissues
KW - METABOLISM
KW - MUSCULOSKELETAL system
KW - COLLAGEN
KW - DISEASES
KW - PHYSIOLOGY
N1 - Accession Number: 12625755; Nigra, Thomas P. 1 Friedland, Michael 1 Martin, George R. 1; Affiliation: 1: Dermatology Branch, NCI and NIDR, National Institutes of Health, Bethesda, Maryland 20014.; Source Info: Jul72, Vol. 59 Issue 1, p44; Subject Term: CONNECTIVE tissues; Subject Term: METABOLISM; Subject Term: MUSCULOSKELETAL system; Subject Term: COLLAGEN; Subject Term: DISEASES; Subject Term: PHYSIOLOGY; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12625755
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carter, Stephen K.
T1 - THE SEARCH FOR THERAPEUTIC CELL CONTROLS BY THE CHEMOTHERAPY PROGRAM OF THE NATIONAL CANCER INSTITUTE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1972/07//
VL - 59
IS - 1
M3 - Article
SP - 128
EP - 138
SN - 0022202X
AB - The chemotherapy program of the National Cancer Institute functions in a major part as a drug development program. The program screens large numbers of compounds each year in a predominately in vivo screen utilizing mouse leukemia L1210 as its most important component. Input to the screen comes from the synthesis of cogeners of known active chemicals (rational base) and from heterogeneous classes of chemicals, uncharacterized antibiotics and plant products (empirical base). The determination of clinical activity and its correlation with the experimental screen depends significantly on an accepted definition of an adequate trial. The clinical trial of new drugs is divided into three phases and the chemotherapy program defines an adequate trial as the establishment of a maximally tolerated dose (phase I) and the evaluation on an adequate dosage schedule in at least six "signal" tumor types (phase II). As a minimum it would be unfair to label a drug as "inactive" until it has been adequately evaluated in at least 10-15 evaluable patients in the six signal tumor types(lung, breast, colon, acute lymphocytic and acute myelocytic leukemia and lymphosarcoma) and found to have insufficient clinical activity in all of them. Defining an adequate trial has to take into account the question of whether an adequate dosage schedule was used. The chemotherapy program has a defined protocol for schedule dependency testing of all of its drugs in experimental systems and in this way attempts to define which schedule might be optimal for usage in men. The positive correlation for such an approach has been shown with drugs such as methotrexate and arabinosyl cytosine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - DRUG therapy
KW - DRUG development
KW - PHARMACOLOGY
KW - LEUKEMIA
KW - ANTIBIOTICS
N1 - Accession Number: 12625903; Carter, Stephen K. 1,2; Affiliation: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014. 2: Chief, Cancer Therapy Evaluation Branch, National Cancer Institute.; Source Info: Jul72, Vol. 59 Issue 1, p128; Subject Term: CANCER treatment; Subject Term: DRUG therapy; Subject Term: DRUG development; Subject Term: PHARMACOLOGY; Subject Term: LEUKEMIA; Subject Term: ANTIBIOTICS; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1523-1747.ep12625903
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Kattwinkel, J.;
AU - Agus, S. G.;
AU - Taussig, L. M.;
AU - di Sant'Agnese, P. A.;
AU - Laster, L.;
T1 - Use of L-arginine and sodium bicarbonate in the treatment of malabsorption due to cystic fibrosis
CT - Use of L-arginine and sodium bicarbonate in the treatment of malabsorption due to cystic fibrosis
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1972/07/01/
VL - 50
IS - Jul
SP - 133
EP - 137
SN - 00314005
AD - National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-2198; Language: English; Trade Name: Cotazyme; Generic Name: Pancrelipase; Chemical Name: Pancrelipase--9001-62-1 Arginine--74-79-3 Sodium bicarbonate--144-55-8; Therapeutic Class: (44:00); AHFS Class: Enzymes pancrelipase; References: 16; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Brenda Sue Martinez
N2 - Intestinal malabsorption due to cystic fibrosis was treated with pancrelipase (Cotazyme), with and without sodium bicarbonate, and with arginine in 10 hospitalized patients serving as their own controls. All of the patients received a 100 g. fat diet and multivitamins and 6 of the 10 patients were taking antibiotics. Stools were collected in 72 hour pools and 2 or 3 pools were obtained during each regimen. The only significant reduction of stool weight, fat and nitrogen was found with Cotazym alone or with sodium bicarbonate. There was a significant loss of weight during arginine administration, in contrast to the weight gain seen with the other regimens.
KW - Pancrelipase--alone and with sodium bicarbonate-;
KW - Arginine--cystic fibrosis-;
KW - Sodium bicarbonate--combination, pancrelipase-;
KW - Cystic fibrosis--malabsorption--intestinal, therapy, comparison of pancrelipase alone and with sodium bicarbonate and arginine, in patients;
KW - Amino acids--arginine--cystic fibrosis, therapy of intestinal malabsorption compared to pancrelipase alone and with sodium bicarbonate, in patients;
KW - Enzymes--pancrelipase--alone and with sodium bicarbonate, comparison to arginine, in intestinal malabsorption due to cystic fibrosis, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jaqueline J.
AU - Houston, Robert
T1 - A comparison of the effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/07//
VL - 80
IS - 4
M3 - Article
SP - 267
EP - 271
SN - 0029845X
AB - The effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque was studied in 182 college students. At an initial screening examination, plaque was assessed using the gingival index. These plaque scores were used to divide the group into those with poor and those with good oral cleanliness. Within each of the two groups, the subjects were randomly assigned to a toothbrushing method and to one of three instructors. Then the participants had their teeth cleaned and were asked to abstain from toothbrushing for one week. After this period of plaque accumulation the participants were again scored for plaque. The test subjects were carefully instructed in the particular tooth-brushing method they were to use and the controls were asked to resume their usual methods. One week later the participants were again examined for plaque. An interaction between toothbrushing method and instructor was found indicating that the effectiveness of a particular method depended in pan on. the instructor. Nevertheless, the CHARTERS' and scrub methods of brushing appeared to be more effective in removing plaque. Generally, subjects with cleaner teeth prior to the stu achieved grater plaque reductions than those with initially poor oral cleanliness. All methods of bruching were relatively ineffective in removing proximal plaque. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOOTHBRUSHES
KW - DENTAL plaque
KW - ORAL hygiene products
KW - DENTAL deposits
KW - GINGIVAL fluid
KW - DENTAL care
N1 - Accession Number: 13235069; Frandsen, Asger M. 1 Barbano, Joseph P. 2 Suomi, John D. 2 Chang, Jaqueline J. 2 Houston, Robert 3; Affiliation: 1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark. 2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland and San Francisco, California. 3: Department ot Health, Oregon State University, Corvallis, Oregon, U.S.A.; Source Info: 1972, Vol. 80 Issue 4, p267; Subject Term: TOOTHBRUSHES; Subject Term: DENTAL plaque; Subject Term: ORAL hygiene products; Subject Term: DENTAL deposits; Subject Term: GINGIVAL fluid; Subject Term: DENTAL care; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 339994 Broom, Brush, and Mop Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WHITMIRE, CARRIE E.
AU - HUEBNER, ROBERT J.
T1 - Inhibition of Chemical Carcinogenesis by Viral Vaccines.
JO - Science
JF - Science
Y1 - 1972/07/07/
VL - 177
IS - 4043
M3 - Article
SP - 60
EP - 61
SN - 00368075
AB - The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C -RNA viral vaccine. Rauscher leukemnia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158128; WHITMIRE, CARRIE E. 1; HUEBNER, ROBERT J. 2; Affiliations: 1: Department of Viral-Chemical Oncology, Microbiological Associates, Inc., 4733 Bethesda Avenue, Bethesda, Maryland 20014; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/ 7/1972, Vol. 177 Issue 4043, p60; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WATERS, TOMMY D.
AU - ANDERSON JR., PAUL S.
AU - BEEBE, GILBERT W.
AU - MILLER, ROBERT W.
T1 - Yellow Fever Vaccination, Avian Leukosis Virus, and Cancer Risk in Man.
JO - Science
JF - Science
Y1 - 1972/07/07/
VL - 177
IS - 4043
M3 - Article
SP - 76
EP - 77
SN - 00368075
AB - Comparison was made between 2659 veterans who died of cancer, during 1950 to 1954 or 1959 to 1963, and matched controls, based on the frequency of yellow fever immunization during World War 11. The vaccine was produced from chick embryos that almost certainly contained avian leukosissarcoma viruses. Among the veterans, no relation was found between vaccination and leukemia, lymphoma, or other cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158136; WATERS, TOMMY D. 1; ANDERSON JR., PAUL S. 1; BEEBE, GILBERT W. 2; MILLER, ROBERT W. 3; Affiliations: 1: School of Public Health, University of Oklahonia Medical Center, Oklahoma City 73104; 2: National Academy of Sciences- National Research Council, Washington, D.C. 20418; 3: Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/ 7/1972, Vol. 177 Issue 4043, p76; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHNITZER, BERTRAM
AU - SODEMAN, THOMAS
AU - MEAD, MICHAEL L.
AU - CONTACOS, PETER G.
T1 - Pitting Function of the Spleen in Malaria: Ultrastructural Observations.
JO - Science
JF - Science
Y1 - 1972/07/14/
VL - 177
IS - 4044
M3 - Article
SP - 175
EP - 177
SN - 00368075
AB - Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158169; SCHNITZER, BERTRAM 1; SODEMAN, THOMAS 1; MEAD, MICHAEL L. 1; CONTACOS, PETER G. 2; Affiliations: 1: Department of Pathology, University of Michigan, Ann Arbor, 48104; 2: Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institutes of Health, Chamnblee, Georgia, 30341; Issue Info: 7/14/1972, Vol. 177 Issue 4044, p175; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOURAS, PETER
AU - BISHOP, PETER O.
T1 - Neural Basis of Vision.
JO - Science
JF - Science
Y1 - 1972/07/14/
VL - 177
IS - 4044
M3 - Article
SP - 188
EP - 189
SN - 00368075
N1 - Accession Number: 85158176; GOURAS, PETER 1; BISHOP, PETER O. 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; 2: John Curtin School of Medical Research, Canberra City, A.C.T., 2601, Australia; Issue Info: 7/14/1972, Vol. 177 Issue 4044, p188; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KWON-CHUNG, K. J.
T1 - Emmonsiella capsulata: Perfect State of Histoplasma capsulatum.
JO - Science
JF - Science
Y1 - 1972/07/28/
VL - 177
IS - 4046
M3 - Article
SP - 368
EP - 369
SN - 00368075
N1 - Accession Number: 85437551; KWON-CHUNG, K. J. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20041; Issue Info: 7/28/1972, Vol. 177 Issue 4046, p368; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sullivan, P. D.
AU - Christine, Barbara
AU - Connelly, Roger
AU - Barrett, Harold
T1 - Analysis of Trends in Age-Adjusted Incidence Rates for 10 Major Sites of Cancer.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/08//
VL - 62
IS - 8
M3 - Article
SP - 1065
EP - 1071
PB - American Public Health Association
SN - 00900036
AB - Based on data from the Connecticut Tumor Registry this report offers trends for the incidence of cancer over a period of thirty years (1935-1965). Findings are reported and a comparison is made of the Connecticut data with that from Alameda County, California. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Public health
KW - Tumors
KW - Lungs -- Cancer
KW - Breast cancer
KW - Diseases -- Risk factors
KW - Regression analysis
KW - Mortality
N1 - Accession Number: 24294231; Sullivan, P. D. 1; Christine, Barbara 2; Connelly, Roger 3; Barrett, Harold 4; Affiliations: 1: Statistician, Connecticut State Department of Health; 2: Director, Connecticut Tumor Registry, Connecticut State Department of Health; 3: Biostatistician, Biometry Branch, National Cancer Institute; 4: Deputy Commissioner, Connecticut State Department of Health, 79 Elm St., Hartford, Connecticut, 06115; Issue Info: Aug1972, Vol. 62 Issue 8, p1065; Thesaurus Term: Epidemiology; Thesaurus Term: Public health; Subject Term: Tumors; Subject Term: Lungs -- Cancer; Subject Term: Breast cancer; Subject Term: Diseases -- Risk factors; Subject Term: Regression analysis; Subject Term: Mortality; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Prien, R. F.;
AU - Caffey, E. M.;
AU - Klett, C. J.;
T1 - Comparison of lithium carbonate and chlorpromazine in the treatment of excited schizo-affectives
CT - Comparison of lithium carbonate and chlorpromazine in the treatment of excited schizo-affectives
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1972/08/01/
VL - 27
IS - Aug
SP - 182
EP - 189
AD - Veterans Administration and National Institute of Mental Health Collaborative Study Group, Central Neuropsychiatric Research Laboratory, V A Hospital, Perry Point, Maryland 21902
N1 - Accession Number: 12-3713; Language: English; Trade Name: Thorazine; Generic Name: Chlorpromazine; Chemical Name: Lithium carbonate--554-13-2 Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine, comparison, lithium carbonate (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate, comparison, chlorpromazine; References: 39; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Eighty-three hospitalized patients with a diagnosis of schizo-affective psychosis, excited state, received lithium carbonate 500 to 3000 mg/day or chlorpromazine hydrochloride (Thorazine) 200 to 3000 mg/day for 3 weeks in a double-blind controlled study. There were 59 male and 24 female patients, ages 19 to 60 years, who were classified as highly active or mildly active. The highly active patients responded more favorably to chlorpromazine than to lithium, whereas mildly active psychotics received similar benefit with either agent. The drop-out rate for the 2 treatment groups was 11% for the chlorpromazine group and 22% for the other due to poor response or toxicity; an additional 7% of the former and 14% of the latter terminated treatment because of development or intercurrent illness. Serum lithium levels ranged from 0.6 to 2.0 meq/l with a median level of 1.0 and 1.3 meq/l for the mildly active group and highly active group, respectively. The most prevalent side effects to chlorpromazine were somnolence, constipation and dry mouth, and to lithium were tremor, dry mouth, hyperactive deep tendon reflexes and transient gastric discomfort.
KW - Lithium carbonate--comparison, chlorpromazine-;
KW - Chlorpromazine--comparison, lithium carbonate-;
KW - Tranquilizers--chlorpromazine, comparison, lithium carbonate--chlorpromazine, schizo-affective, therapy, in patients;
KW - Psychotherapeutic agents--lithium carbonate, comparison, chlorpromazine--psychoses, schizo-affective, therapy in patients;
KW - Blood levels--lithium carbonate--psychoses, therapy, in patients;
KW - Metabolism--lithium carbonate--blood levels, psychoses therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - ABST
AU - Robbins, J. H.
AU - Gart, J. J.
AU - Levis, W. R.
AU - Burk, P. G.
T1 - THE MILLIPORE FILTER ASSAY TECHNIQUE FOR MEASURING TRITIATED THYMIDINE INCORPORATION INTO DNA IN LEUCOCYTE CULTURES.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/08//
VL - 11
IS - 4
M3 - Abstract
SP - 629
EP - 640
PB - Wiley-Blackwell
SN - 00099104
AB - In this paper we present in detail the very rapid and sensitive Millipore filter assay technique for measuring tritiated thymidine incorporation during semiconservativé DNA synthesis in human peripheral blood leucocyte cultures. Leucocytes which have been incubated with tritiated thymidine are trapped on a Millipore filter which is then suitably washed and dried. The filter is then immersed in scintillation fluid in a double-vial apparatus designed to ensure a reproducible counting geometry. Alternatively, the filter and its radioactive contents can be combusted to tritiated water, the radioactivity of which is then determined in a homogeneous counting system. The parameters related to the Miilipore filter assay technique are presented, and its present uses and general applicability discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYMIDINE
KW - DNA
KW - LEUCOCYTES
KW - CELL culture
KW - RADIOACTIVITY
KW - BLOOD cells
N1 - Accession Number: 14572813; Robbins, J. H. 1 Gart, J. J. 1 Levis, W. R. 1 Burk, P. G. 1; Affiliation: 1: National Cancer Institute, National Institutes of Health, U.S.A.; Source Info: Aug72, Vol. 11 Issue 4, p629; Subject Term: THYMIDINE; Subject Term: DNA; Subject Term: LEUCOCYTES; Subject Term: CELL culture; Subject Term: RADIOACTIVITY; Subject Term: BLOOD cells; Number of Pages: 12p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BLOOM, F. E.
AU - HOFFER, B. J.
AU - BATTENBERG, E. R.
AU - SIGGINS, G. R.
AU - STEINER, A. L.
AU - PARKER, C. W.
AU - WEDNER, H. J.
T1 - Adenosine 3',5'-Monophosphate Is Localized in Cerebellar Neurons: Immunofluorescence Evidence.
JO - Science
JF - Science
Y1 - 1972/08/04/
VL - 177
IS - 4047
M3 - Article
SP - 436
EP - 438
SN - 00368075
AB - Adenosine 3',5'-monophosphate is localized in specific cerebellar neurons, as shown by fluorescence immunocytochemistry with a specific rabbit immunoglobulin. Positive staining is exhibited by Purkinje neurons and granule cells. The increase in concentration of cyclic adenosine monophosphate in the cerebellum, which is known to follow decapitation, is represented by greatly increased fluorescence of Purkinje neurons only. These immunofluorescence data provide the first evidence for localization of cyclic adenosine monophosphate in specific neurons and may permit further exploration into the role of this cyclic nucleotide in neuronal function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85362850; BLOOM, F. E. 1; HOFFER, B. J. 1; BATTENBERG, E. R. 1; SIGGINS, G. R. 1; STEINER, A. L. 2; PARKER, C. W. 3; WEDNER, H. J. 3; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Medicine, Albany Medical College, Albany, New York; 3: Division of Immunology, Department of Medicine, Washington University Medical School, Saint Louis, Missouri 63110; Issue Info: 8/ 4/1972, Vol. 177 Issue 4047, p436; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Duttera, M. J.;
AU - Carolla, R. L.;
AU - Gallelli, J. F.;
AU - Gullion, D. S.;
AU - Keim, D. E.;
AU - \ET/;
T1 - Hematuria and crystalluria after high-dose 6-mercaptopurine administration
CT - Hematuria and crystalluria after high-dose 6-mercaptopurine administration
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/08/10/
VL - 287
IS - Aug 10
SP - 292
EP - 294
SN - 00284793
AD - Building 10, Room 6B15, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-0224; Language: English; Chemical Name: Mercaptopurine--6112-76-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mercaptopurine; References: 8; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - Nine children with acute leukemia experienced hematuria and crystalluria in association with high-dosage I.V. mercaptopurine administration. It was concluded that I.V. doses exceeding 750 mg./m.\SU/2\BS/ can produce toxic effects and that doses in excess of 500 mg./m.\SU/2\BS/ should only be given to patients who have not responded to lower dosages.
KW - Mercaptopurine--toxicity-;
KW - Toxicity--mercaptopurine--hematuria and crystalluria, following high dosage injections, in leukemic children;
KW - Antineoplastic agents--mercaptopurine--toxicity, hematuria and crystalluria, following high dosage injections, in leukemic children;
KW - Dosage--mercaptopurine--injections, high, toxicity, hematuria and crystalluria, in leukemic children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - KLEIN, DAVID C.
AU - WELLER, JOAN L.
T1 - Rapid Light-Induced Decrease in Pineal Serotonin N-Acetyltransferase Activity.
JO - Science
JF - Science
Y1 - 1972/08/11/
VL - 177
IS - 4048
M3 - Article
SP - 532
EP - 533
SN - 00368075
AB - Light acting by way of the eye causes the dark-induced activity of serotonin N-acetyltransferase in the pineal gland of the rat to decrease with a halving time of about 3 minutes. This effect, which is one of the more rapid physiological changes known to occur in the activity of any enzyme that metabolizes biogenic amines, appears to explain the rapid increase in the concentration of pineal serotonin that is caused by light exposure at night. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116833; KLEIN, DAVID C. 1; WELLER, JOAN L. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 8/11/1972, Vol. 177 Issue 4048, p532; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STETTEN JR., DEWITT
T1 - Research and Planning.
JO - Science
JF - Science
Y1 - 1972/08/18/
VL - 177
IS - 4049
M3 - Article
SP - 563
EP - 563
SN - 00368075
N1 - Accession Number: 85116841; STETTEN JR., DEWITT 1; Affiliations: 1: Director, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 8/18/1972, Vol. 177 Issue 4049, following p563; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WHITLOCK JR., JAMES P.
AU - COOPER, HERBERT L.
AU - GELBOIN, HARRY V.
T1 - Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]lanthracene.
JO - Science
JF - Science
Y1 - 1972/08/18/
VL - 177
IS - 4049
M3 - Article
SP - 618
EP - 619
SN - 00368075
AB - A mixed-function oxidase that requires reduced nicotinamide adenine dinucleotide phosphate, is carbon monoxide sensitive, and is drug-metabolizing is present in human lymphocytes and is increased to different levels by treatment with phytohemagglutinin, pokeweed mitogen, and a polycyclic hydrocarbon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116866; WHITLOCK JR., JAMES P. 1; COOPER, HERBERT L. 2; GELBOIN, HARRY V. 3; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Cell Biology Section, Laboratory of Biochemistry, National Institute of Dental Research, Bethesda, Maryland; 3: Chemistry Branch, National Cancer Institute, Bethesda, Maryland; Issue Info: 8/18/1972, Vol. 177 Issue 4049, p618; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FORMAN, DAVID S.
AU - LEDEEN, ROBERT W.
T1 - Axonal Transport of Gangliosides in the Goldfish Optic Nerve.
JO - Science
JF - Science
Y1 - 1972/08/18/
VL - 177
IS - 4049
M3 - Article
SP - 630
EP - 633
SN - 00368075
AB - Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116872; FORMAN, DAVID S. 1; LEDEEN, ROBERT W. 2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461; Issue Info: 8/18/1972, Vol. 177 Issue 4049, p630; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - COSTELL, RONALD M.
AU - LUNDE, DONALD T.
AU - KOPELL, BERT S.
AU - WITTNER, WILLIAM K.
T1 - Contingent Negative Variation as an Indicator of Sexual Object Preference.
JO - Science
JF - Science
Y1 - 1972/08/25/
VL - 177
IS - 4050
M3 - Article
SP - 718
EP - 720
SN - 00368075
AB - The contingent negative variation (CNV) was recorded in the interval between paired visual exposures of male nudes, female nudes, and sexually "neutral" silhouettes. Groups of 12 male and 12 female subjects viewing 50 randomized presentations from each stinmulus category responded with averaged CNV amplitudes proportional to the predicted degree of sexual interest in the stimulus classes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87428660; COSTELL, RONALD M. 1; LUNDE, DONALD T. 2; KOPELL, BERT S. 2; WITTNER, WILLIAM K. 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305; Issue Info: 8/25/1972, Vol. 177 Issue 4050, p718; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Feldman, D. B.;
AU - Rall, D. P.;
AU - Moore, J. A.;
T1 - Dry detergent and soap effects on the rabbit eye
CT - Dry detergent and soap effects on the rabbit eye
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/08/28/
VL - 221
IS - Aug 28
SP - 1055
AD - National Institutes of Health, Research Triangle Park, North Carolina
N1 - Accession Number: 10-0022; Language: English; References: 2; Publication Type: Letters; Journal Coden: JAMAAP; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - Laundry products containing soap powder, phosphate, carbonate or metasilicate, and dishwasher products containing phosphate or metasilicate were tested in order to determine the degree of toxicity to eyes of rabbits. Tables listing results are included. With laundry products, soap powder was the least damaging to the cornea and adjacent structures. Ocular reaction to phosphate detergents persisted longer than soap. The reaction to carbonate and metasilicate detergents was more intense than in the first 2 products. With the dishwasher products, corneal toxicity was more severe with the metasilicate detergent.
KW - Soaps--laundry--toxicity, effects, on rabbit eyes, compared to phosphate, carbonate and metasilicate containing products;
KW - Toxicity--soaps--laundry, effects, on rabbit eyes, compared to phosphate, carbonate and metasilicate containing products;
KW - Detergents--toxicity--effects, on rabbit eyes, comparison of phosphate, carbonate, and metasilicate containing products to soap;
KW - Toxicity--detergents--effects, on rabbit eyes, comparison of phosphate, carbonate, and metasilicate containing products to soap;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gralnick, H. R.;
AU - McGinniss, M.;
AU - Halterman, R.;
T1 - Thrombocytopenia with sodium cephalothin therapy
CT - Thrombocytopenia with sodium cephalothin therapy
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/09/01/
VL - 77
IS - Sep
SP - 401
EP - 404
SN - 00034819
AD - Hematology Service, Clinical Center, Building 10, Room 5N-236, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1433; Language: English; Chemical Name: Cephalothin--153-61-7; Therapeutic Class: (8:12); AHFS Class: Antibiotics cephalothin; References: 8; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Judith A. Kepler
N2 - Thrombocytopenia occurred on 2 separate occasions in a patient while she was receiving sodium cephalothin. In vitro and in vivo studies with cephalothin showed nonspecific protein binding to platelets and a specific anticephalothin antibody that resulted in platelet agglutination in vitro and shortened platelet survival and thrombocytopenia in vivo.
KW - Cephalothin--sodium-;
KW - Drugs, adverse reactions--cephalothin--sodium, thrombocytopenia, in patient;
KW - Antibiotics--cephalothin--sodium, adverse reactions, thrombocytopenia, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bunney, W. E., Jr.;
AU - Goodwin, F. K.;
AU - Murphy, D. L.;
T1 - Switch process in manic-depressive illness
CT - Switch process in manic-depressive illness
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1972/09/01/
VL - 27
IS - Sep
SP - 312
EP - 317
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 11-0514; Language: English; Trade Name: Eskalith--Lithane--Lithonate; Generic Name: Lithium carbonate; Lithium carbonate; Lithium carbonate; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 47; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - The biological theories concerning manic-depressive illness, the psychobiological factors and proposed genetic abnormality involved with the manic-depressive switch process and the mechanisms of action of lithium carbonate (Eskalith, Lithane, Lithonate) are reviewed. The biochemical interaction of endogenous electrolytes, norepinephrine, lithium and a transport carrier is also considered.
KW - Lithium carbonate--psychoses-;
KW - Psychotherapeutic agents--lithium carbonate--psychoses, manic depressive, therapy, in patients;
KW - Mechanism of action--lithium carbonate--psychoses, manic depressive, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Weiss, J. L.;
AU - Watanabe, A. M.;
AU - Lemberger, L.;
AU - Tamarkin, N. R.;
AU - Cardon, P. V.;
T1 - Cardiovascular effects of delta-9-tetrahydrocannabinol in man
CT - Cardiovascular effects of delta-9-tetrahydrocannabinol in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1972/09/01/
VL - 13
IS - Sep-Oct
SP - 671
EP - 684
SN - 00099236
AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1782; Language: English; References: 31; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effects of 0.3 mg./kg. oral tetrahydrocannabinol on the circulatory system was investigated in 8 male cannabis users. Recumbent and upright heart rate, recumbent mean arterial blood pressure, forearm blood flow, and calculated forearm conductance all increased significantly following drug administration. Significant shortening of ventricular pre-ejection period and attenuation or abolition of reflex venoconstriction in response to a deep breath were also seen. Mean arterial pressure decreased transiently with head-up tilt and was associated with presyncope in 7 subjects, although cardioacceleratory response and forearm arteriolar constriction remained intact. Plasma levels of labeled THC and its metabolites were maximal at 3 hours. Gastrointestinal absorption was 95% complete. Urinary excretion of free epinephrine was significantly higher during the 6 hour period following \TR/-9-THC administration than during a similar control period. Free norepinephrine excretion was unchanged. Several of the cardiovascular effects seen appear to be consistent with increased sympathoadrenal activity. This suggests the possibility that augmented epinephrine secretion is in part responsible for these circulatory changes.
KW - Tetrahydrocannabinol--oral-;
KW - Blood levels--tetrahydrocannabinol--oral, in males;
KW - Absorption--tetrahydrocannabinol--oral, in males;
KW - Metabolism--tetrahydrocannabinol--oral, in males;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Canellos, G. P.;
AU - Young, R. C.;
AU - DeVita, V. T.;
T1 - Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
CT - Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1972/09/01/
VL - 13
IS - Sep-Oct
SP - 750
EP - 754
SN - 00099236
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 10-2186; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Twenty one patients with Hodgkin's disease who were in relapse following extensive radiation therapy were treated with a combination chemotherapy program, which included nitrogen mustard (mechlorethamine), vincristine, prednisone, and procarbazine for 6 monthly cycles. Sixteen patients (76%) achieved complete remission. In a comparable group of patients with extensive disease but no previous radiotherapy the over-all remission rate and the degree of myelosuppression were similar. The interval between the end of radiotherapy and the onset of chemotherapy did not correlate with the extent of subsequent drug toxicity. Relapse of Hodgkin's disease in the patients following intensive radiotherapy with curative intent does not preclude a subsequent excellent response to combination chemotherapy and a prolonged disease-free interval.
KW - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW - Procarbazine--prednisone, mechlorethamine and vincristine-;
KW - Antineoplastic agents--combined therapy--Hodgkin's disease, in patients;
KW - Combined therapy--vincristine, procarbazine and prednisone--Hodgkin's disease, in patients;
KW - Combined therapy--procarbazine, prednisone and vincristine--Hodgkin's disease, in patients;
KW - Combined therapy--prednisone, procarbazine and vincristine--Hodgkin's disease, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chez, R. A.;
T1 - Role of the pharmacist in family planning: a Pennsylvania survey
CT - Role of the pharmacist in family planning: a Pennsylvania survey
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1972/09/01/
VL - NS12
IS - Sep
SP - 464
EP - 466
AD - Pregnancy Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-3541; Language: English; Journal Coden: JPHAA3; Section Heading: Pharmacy Practice; Abstract Author: Drucella Andersen
N2 - This survey reflects pharmacists' attitudes regarding the sale and display of contraceptives. A total of 1,490 questionnaires were mailed to members of the Pennsylvania Pharmaceutical Association. A 52% response was obtained within a 3 month period after a single mailing. There was no preliminary notification nor an attempt at follow-up. Specifically, there was a marked difference in the types of contraceptives displayed, with foams, creams, and jellies 8 times more frequently displayed than condoms. The question concerning sales to unmarried minors was answered affirmatively by over 33% of the respondents, with religion and age being a significant factor in the negative respondents. It was also ascertained that the pharmacist was rarely asked for contraceptive advice from men and women patrons.
KW - Pharmacists, community--contraceptives--display, and sales, attitudes, survey;
KW - Sociology--pharmacists, community--contraceptives, sale and display, survey of attitudes;
KW - Contraceptives--advertising--display, and sale, pharmacists attitudes;
KW - Marketing--contraceptives--pharmacists, community, attitudes surveyed regarding display and sale;
KW - Information--contraceptives--pharmacists, community, rarely asked for advice;
KW - Community service--contraceptives--advertising, and display, pharmacists attitudes;
KW - Advertising--contraceptives--pharmacy, community, attitudes, survey;
KW - Patient information--consultation--contraceptives, survey, pharmacists attitudes;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Christian, D. G.;
AU - Cornelis, W. A.;
AU - Fortner, C. L.;
T1 - Acute leukemias
CT - Acute leukemias
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1972/09/01/
VL - NS12
IS - Sep
SP - 473
EP - 481
AD - Patient Care Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, USPHS Hospital, Baltimore, Maryland
N1 - Accession Number: 12-3247; Language: English; References: 7; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Drucella Andersen
N2 - Information on the treatment of the acute leukemias, including some background on the pathology, etiology, and the diagnosis of the diseases are presented as a source of continuing education for the pharmacist.
KW - Antineoplastic agents--leukemias--acute, therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Adams, E.;
AU - Chandler, R.;
AU - Farkas, R.;
T1 - Sulfur colloid flocculation due to acid leached aluminum
CT - Sulfur colloid flocculation due to acid leached aluminum
JO - J. Nucl. Med.
JF - J. Nucl. Med.
Y1 - 1972/09/01/
VL - 13
IS - Sep
SP - 707
EP - 708
AD - National Institutes of Health, Department of Pharmacy, Radiopharmaceutical Services, Bethesda, Maryland 20014
N1 - Accession Number: 10-2389; Language: English; Chemical Name: Aluminum--7429-90-5; Publication Type: Letters; Journal Coden: JNMEAQ; Section Heading: Pharmaceutical Technology; Abstract Author: Nelson Der
N2 - Aluminum may be leached from the closure and/or syringe needle of a commercial kit used to prepare Tc 99m sulfur colloid. The resultant high concentration of aluminum can cause the formation of a flocculent precipitate which will result in an unusable preparation.
KW - Aluminum--contamination-;
KW - Needles--aluminum--incompatibilities, flocculation in technetium Tc 99m injection;
KW - Diagnostic agents--technetium--Tc 99m, sulfur colloid, contamination with aluminum flocculation;
KW - Equipment--kits--injections, contamination, aluminum flocculation, from acid-leached aluminum in Tc 99m, sulfur colloid;
KW - Contamination--technetium--Tc 99m, aluminum, from needle produces precipitate;
KW - Incompatibilities--aluminum and technetium--Tc 99m, from needle results in precipitate;
KW - Containers--technetium--Tc 99m, aluminum from needle results in precipitate;
KW - Injections--technetium--Tc 99m, incompatibilities, aluminum from needle results in precipitate;
KW - Radiopharmaceuticals--technetium--Tc 99m, incompatibilities, aluminum from needle results in precipitate;
KW - Closures--aluminum--incompatibilities, from needle results in precipitate of technetium Tc 99m;
KW - Stability--technetium--Tc 99m, incompatible with aluminum needle;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Paull, K. D.;
AU - Engle, R. R.;
AU - Twanmoh, L.;
AU - Wood, H. B., Jr.;
AU - Driscoll, J. S.;
T1 - Synthesis of 9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine
CT - Synthesis of 9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/09/01/
VL - 61
IS - Sep
SP - 1481
EP - 1483
SN - 00223549
AD - Drug Development Branch, Drug Research and Development, Chemotherapy, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-0148; Language: English; References: 7; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - Synthesis of a precursor to the cytotoxic compounds isolated from the genus Thalictrum is described.
KW - 9-(3,4-Dimethoxyphenoxy)-1,2,10-trimethoxyaporphine--carcinogens-;
KW - Carcinogens--9-(3,4-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine--synthesis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Connor, Robert J.
T1 - Grouping for Testing Trends in Categorical Data.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1972/09//
VL - 67
IS - 339
M3 - Article
SP - 601
SN - 01621459
AB - In many studies there is believed to be a trend in a categorical variate with a continuous variate. Often in these cases it is desired to test for the trend using k groups farmed from the continuous variable. This article is concerned with the grouping problem where the goal is essentially to maximize the asymptotic efficiency of the test. Optimal classes are given for k = 2, 3, 4, 5 and 6 for the uniform, normal and exponential distributions. Also, the number of groups to use and the "robustness" of the optimal grouping are investigated. It is noted that the "mathematical problem" in determining the optimal classes appears in other studies; a rationale for this is presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - MATHEMATICAL analysis
KW - PROBLEM solving
KW - CATEGORIES (Mathematics)
KW - VARIABLES (Mathematics)
KW - ASYMPTOTIC efficiencies (Statistics)
KW - VARIATE difference method
KW - EXPONENTIAL sums
N1 - Accession Number: 4608646; Connor, Robert J. 1; Affiliations: 1: Research mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; Issue Info: Sep72, Vol. 67 Issue 339, p601; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: PROBLEM solving; Subject Term: CATEGORIES (Mathematics); Subject Term: VARIABLES (Mathematics); Subject Term: ASYMPTOTIC efficiencies (Statistics); Subject Term: VARIATE difference method; Subject Term: EXPONENTIAL sums; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Nylen, Marie U.
AU - Omnell, Karl-Åke
AU - Löfgren, Claes-Göran
T1 - An electron microscopic study of tetracycline-induced enamel defects in rat incisor enamel.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/09//
VL - 80
IS - 5
M3 - Article
SP - 384
EP - 409
SN - 0029845X
AB - The structure of incremental bands and gross hypoplastic lesions in rat incisor enamel which resulted from single or multiple injections with tetracycline hydrochloride was studied in the electron microscope. Both types of lesions which were investigated previously using microradiography and fluorescence microscopy exhibited many unusual structural features which are discussed in relation to current concepts of normal enamel formation. Disturbances in packing and organization were common to all the lesions indicating a primary interference with the first phase of enamel formation, i.e. matrix formation and initial mineralization. These changes were the main cause of the various mineralization disturbances seen in the microradiograms. Temporary and permanent interference with the second or maturation phase, i.e. a crystal growth, was also evident but only as a corollary to the principal disturbance. This, and other evidence, suggests that tetracycline as well as many other chemical agents achieve their principal effects on enamel formation by injuring pre-secretory or secretory ameloblasts. Thus it appears that most developmental mineralization disturbances are symptomatic of hypoplastic lesions or are a sequela to the cell injury which also causes the hypoplastic lesions. Because of that it is suggested that commonly used division between hypoplastic and hypomineralized defects be abandoned. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACYCLINE
KW - INCISORS
KW - ELECTRON microscopy
KW - TEETH
KW - RATS
KW - FLUORESCENCE
N1 - Accession Number: 13238105; Nylen, Marie U. 1 Omnell, Karl-Åke 2 Löfgren, Claes-Göran 3; Affiliation: 1: Laboratory of Biological Structure, National Institute of Dental Research, Bethesda, Md 2: National Institutes of Health, Bethesda, Md 3: Department of Oral Roentgen Diagnosis Dentistry, University of Lund, School of Dentistry, Malmö, Sweden; Source Info: 1972, Vol. 80 Issue 5, p384; Subject Term: TETRACYCLINE; Subject Term: INCISORS; Subject Term: ELECTRON microscopy; Subject Term: TEETH; Subject Term: RATS; Subject Term: FLUORESCENCE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 26p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frandsen, A. M
AU - MacClendon, B. J.
AU - Chang, J. J.
AU - Creighton, W. E.
T1 - The effect of oral rinsing with sodium fluoride on the gingiva of children.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/09//
VL - 80
IS - 5
M3 - Article
SP - 445
EP - 448
SN - 0029845X
AB - The effect of a weekly mouthrinsing with a 0.2 % sodium fluoride solution on the gingiva of children was investigated using a double-blind technique. One hundred and twenty-seven Grade 2 children (6-7 years old) and 126 Grade 6 children (12-13 years old) of Negro and Caucasian background formed the study groups. In each age group, fluoride and placebo subgroups were formed which were balanced as to sex, race and number. Assessments were made for the presence of gingival inflammation, plaque and calculus on six selected permanent teeth. The results indicated that in neither age group was the degree of gingivitis influenced by the fluoride mouthrinse. Further, no differences between the two age groups in degree of gingivitis and amount of plaque were noted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUMS
KW - PERIODONTIUM
KW - SODIUM fluoride
KW - FLUORIDES
KW - CHILDREN
KW - MOUTH
KW - PERIODONTICS
N1 - Accession Number: 13238240; Frandsen, A. M 1 MacClendon, B. J. 2,3 Chang, J. J. 2,3 Creighton, W. E. 4; Affiliation: 1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark 2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A. 3: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and WelfareSan Francisco, California, U.S.A. 4: Division of Public Health, Multnomah County, Oregon, U.S A.; Source Info: 1972, Vol. 80 Issue 5, p445; Subject Term: GUMS; Subject Term: PERIODONTIUM; Subject Term: SODIUM fluoride; Subject Term: FLUORIDES; Subject Term: CHILDREN; Subject Term: MOUTH; Subject Term: PERIODONTICS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Moore, J. A.;
T1 - Teratogenicity of hycanthone in mice
CT - Teratogenicity of hycanthone in mice
JO - Nature (London)
JF - Nature (London)
Y1 - 1972/09/08/
VL - 239
IS - Sep 8
SP - 107
EP - 109
AD - National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, North Carolina 27709
N1 - Accession Number: 10-2149; Language: English; Chemical Name: Hycanthone--3105-97-3; References: 2; Journal Coden: NATUAS; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2 - Hycanthone methanesulfonate, in doses ranging from 10-50 mg./kg., caused teratogenetic effects in mice.
KW - Hycanthone--methanesulfonate-;
KW - Schistosomicides--hycanthone--methanesulfonate, teratogenicity, in mice;
KW - Teratogenicity--hycanthone--methanesulfonate, in mice;
KW - Toxicity--hycanthone--methanesulfonate, teratogenicity, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - HOLLINSHEAD, ARIEL C.
AU - MCWRIGHT, C. GLEN
AU - ALFORD, T. CRANDALL
AU - GLEW, DONALD H.
AU - GOLD, PHIL
AU - HERBERMAN, RONALD B.
T1 - Separation of Skin Reactive Intestinal Cancer Antigen from the Carcinoembryonic Antigen of Gold.
JO - Science
JF - Science
Y1 - 1972/09/08/
VL - 177
IS - 4052
M3 - Article
SP - 887
EP - 889
SN - 00368075
AB - Soluible fractions of humtlan intestinal cancer and fetal intestinal cell mnembranes produced delayed hypersensitivity reactions in patients with intestinal cancer. These solible fractions and perchloric acid extracts of intestinal cancer cells were fractionated by polacrylamide-gel electrophoresis. The Gold carcinoembryonic antigen was found in a region of the gels diflerent from that of the skin reactive antigen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116946; HOLLINSHEAD, ARIEL C. 1; MCWRIGHT, C. GLEN 1; ALFORD, T. CRANDALL 1; GLEW, DONALD H. 1; GOLD, PHIL 2; HERBERMAN, RONALD B. 3; Affiliations: 1: Laboratory for Virus and Cancer Research, George Washington University Medical Center. Washington, D.C. 20037; 2: Division of Clinical Immunology, McGill University Clinic, Montreal General Hospital, Montreal 109, Quebec; 3: Cellular and Tumor Immunology Section, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/ 8/1972, Vol. 177 Issue 4052, p887; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NELSON, PHILLIP G.
AU - PEACOCK, JOHN H.
T1 - Acetylcholine Responses in L Cells.
JO - Science
JF - Science
Y1 - 1972/09/15/
VL - 177
IS - 4053
M3 - Article
SP - 1005
EP - 1007
SN - 00368075
AB - L cells, a family of continuous cell lines of mouse fibroblastic origin, generate a prolonged active membrane hyperpolarization (the hyperpolarizing activation response) when stimulated mechanically or electrically lontophoretically applied acetylcholine elicits a similar response; atropine blocks the acetylcholine but not the electrically or Imechanically elicited responses. The hyperpolarizing activation response can also be elicited by electrical, mechanical, or acetylcholine stimulation of cells adjacent to the recorded cell. Propagation of the response from one cell to another is not dependent on direct electrical coupling between cells and is not blocked by application of a bath containing atropine or curare. These results show that L cells are capable of generating an active electrical response that they are sensitive to at least one neurotransmitter (acetylcholine), and that humorally mediated interaction (probably noncholinergic) between L cells occurs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116989; NELSON, PHILLIP G. 1; PEACOCK, JOHN H. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/15/1972, Vol. 177 Issue 4053, p1005; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAUFMAN, DAVI G.
AU - BAKER, MARY S.
AU - SMITH, JOSEPH M.
AU - HENDERSON, WILLIAM R.
AU - HARRIS, CURTIS C.
AU - SPORN, MICHAEL B.
AU - SAFFIOTTI, UMBERTO
T1 - RNA Metabolism in Tracheal Epithelium: Alteration in Hamsters Deficient in Vitamin A.
JO - Science
JF - Science
Y1 - 1972/09/22/
VL - 177
IS - 4054
M3 - Article
SP - 1105
EP - 1108
SN - 00368075
AB - The electrophoretic pattern of RNA molecules that are synthesized in vitro in tracheal epithelium from hamsters deficient in vitamin A differs from that of RNA synthesized in normal, pair-fed control hamsters. There is less RNA of low electrophoretic mobility in the epithelial cells deficient in vitamin A. This alteration is reversed after the deficient animals have been treated with vitamin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117020; KAUFMAN, DAVI G. 1; BAKER, MARY S. 1; SMITH, JOSEPH M. 1; HENDERSON, WILLIAM R. 1; HARRIS, CURTIS C. 1; SPORN, MICHAEL B. 1; SAFFIOTTI, UMBERTO 1; Affiliations: 1: Lung Cancer Unit, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1105; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ABRELL, JOHN W.
AU - SMTITH, R. GRAHAM
AU - ROBERT, MARJORIE S.
AU - GALLO, ROBERT C.
T1 - DNA Polymerases from RNA Tumor Viruses and Human Cells: Inhibition by Polyuridylic Acid.
JO - Science
JF - Science
Y1 - 1972/09/22/
VL - 177
IS - 4054
M3 - Article
SP - 1111
EP - 1114
SN - 00368075
AB - Polyuridylic acid inhibited DNA polyinerases purified from three species of oncornaviruses as well as three out of seven DNA polymerases purified from cells. Viral and cellular DNA polymerases could not be distinguished by polyuridylic acid inhibition, but were easily distinguished by their temnplate prefer-ences in the presence of magnesium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117023; ABRELL, JOHN W. 1; SMTITH, R. GRAHAM 1; ROBERT, MARJORIE S. 1; GALLO, ROBERT C. 1,2; Affiliations: 1: Bionetics Research Laboratories, Bethesda, Maryland 20014; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1111; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCOLNICK, EDWARD M.
AU - PARKS, WADE P.
AU - TODARO, GEORGE J.
T1 - Reverse Transcriptases of Primate Viruses as Immunological Markers.
JO - Science
JF - Science
Y1 - 1972/09/22/
VL - 177
IS - 4054
M3 - Article
SP - 1119
EP - 1121
SN - 00368075
AB - Antibodies were prepared against the DNA polymerases (reverse transcriptases) of three potentially oncogenic RNA viruses of primates. Two type C viruses, isolated from a woolly mionkey fibrosarcoma and fromn a gibbon ape lymphosarcoma, have polyimerases that are immunologically related to each other and are distinct from the type C viruses isolated from other mammals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117026; SCOLNICK, EDWARD M. 1; PARKS, WADE P. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leuikemia and Lymphoma Branch and Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1119; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYATT, RICHARD J.
AU - VAUGHAN, THOMAS
AU - GALANTER, MARC
AU - KAPLAN, JONATHAN
AU - GREEN, RICHARD
T1 - Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan.
JO - Science
JF - Science
Y1 - 1972/09/22/
VL - 177
IS - 4054
M3 - Article
SP - 1124
EP - 1126
SN - 00368075
AB - Oral admninistration of the serotonin precur''sort L-5-hylroxytryptophan with a peripheral decarboxylase inihibitor produced Mild to moderate improveilzent in six of seven chronic uindciffer-entiated schizophreniic patienits who were resistanit to phenothiazine treatment, as coinpared to ani oral administration of a placebo. Two of foutr chroniic parainoid schizophrenic patients who wsere resistant to pheniothiazine treatment becamtie worse with 5-hydroxytryptophanl, olle iunproved. It is presumed that these psychological changes were directly or indirectly prodiuced from increases in brain serotonlin. Indirect data from aniimals anid hiumiians indicate that there mlay be an abnorimality in serotonini metabolism in soime schizophrenics. While ouir data are conisistelnt iwith this hypothesis, other explanations for otir data imust be entertainied. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117029; WYATT, RICHARD J. 1; VAUGHAN, THOMAS 1; GALANTER, MARC 1; KAPLAN, JONATHAN 1; GREEN, RICHARD 1; Affiliations: 1: Laboratory of Clinical Psychopharmnacology, Division of Special Menztal Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1124; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAMPRECHT, FRIEDHELM
AU - EICHELMAN, BURR
AU - THOA, NGUYEN B.
AU - WILLIAMS, REDFORD B.
AU - KoPIN, IRWIN J.
T1 - APPOINTMENTS.
JO - Science
JF - Science
Y1 - 1972/09/29/
VL - 177
IS - 4055
M3 - Article
SP - 1179
EP - 1215
SN - 00368075
N1 - Accession Number: 85138456; LAMPRECHT, FRIEDHELM 1; EICHELMAN, BURR 2; THOA, NGUYEN B. 3; WILLIAMS, REDFORD B. 4; KoPIN, IRWIN J. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychobiology, National Institute of Mental Health; 3: Laboratory of Clinical Science; 4: Laboratory of Clinical Psychobiology; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1179; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aviv, DVORA
AU - THOMPSON, E. BRAD
T1 - Variation in Tyrosine Aminotransferase Induction in HTC Cell Clones.
JO - Science
JF - Science
Y1 - 1972/09/29/
VL - 177
IS - 4055
M3 - Article
SP - 1202
EP - 1203
SN - 00368075
AB - Examination of tyrosine aminotransferase induction in many HTC cell subclones revealed a wide and unstable distribution of inducibility. The instability of this phenotype cannot easily be explained by classical mutation rates. These observations may be important in interpreting certain cell fusion experiments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138472; Aviv, DVORA 1; THOMPSON, E. BRAD 1; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1202; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAMPRECHT, FRIEDHELM
AU - EICHELMAN, BURR
AU - THOA, NGUYEN B.
AU - WILLIAMS, REDFORD B.
AU - KoPIN, IRWIN J.
T1 - Rat Fighting Behavior: Serum Dopamine-β-Hydroxylase and Hypothalamic Tyrosine Hydroxylase.
JO - Science
JF - Science
Y1 - 1972/09/29/
VL - 177
IS - 4055
M3 - Article
SP - 1214
EP - 1215
SN - 00368075
AB - Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-β-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine- f,-hydroxylase activity retuirned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis possibly resulting in a persistent increase in aggressive behavior. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138478; LAMPRECHT, FRIEDHELM 1; EICHELMAN, BURR 2; THOA, NGUYEN B. 3; WILLIAMS, REDFORD B. 4; KoPIN, IRWIN J. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychobiology, National Institute of Mental Health; 3: Laboratory of Clinical Science; 4: Laboratory of Clinical Psychobiology; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1214; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Weppner, R. S.;
AU - Stephens, R. C.;
AU - Conrad, H. T.;
T1 - Methadone: some aspects of its legal and illegal use
CT - Methadone: some aspects of its legal and illegal use
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1972/10/01/
VL - 129
IS - Oct
SP - 451
EP - 455
SN - 0002953X
AD - National Institute of Mental Health, Clinical Research Center, Leestown Pike, Lexington, Kentucky 40507
N1 - Accession Number: 10-5026; Language: English; Chemical Name: Methadone--76-99-3; References: 12; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; PharmacologySociology, Economics and Ethics; Abstract Author: Louis Houle, Jr.
N2 - In a study of 336 patients, it is found that methadone does not block the euphoric effects of other opiates, and that methadone is the drug of choice for some addicts. Three basic areas are covered: (1) the prevalence of methadone use among a sample of institutionalized narcotic addicts; (2) the circumstances of illegal methadone use among this sample of narcotic addicts; and (3) the circumstances surrounding previous participation in methadone maintenance programs (including illegal drug use). The results show that success of methadone maintenance does not mean the programs are immune to diversion of methadone or to other abuses.
KW - Methadone--maintenance-;
KW - Drug abuse--methadone--maintenance, diversion, discussion, in patients;
KW - Dependence--narcotics--therapy, methadone maintenance, abuses, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Berk, P. D.;
AU - Blaschke, T. F.;
T1 - Detection of Gilbert's syndrome in patients with hemolysis. Method using radioactive chromium
CT - Detection of Gilbert's syndrome in patients with hemolysis. Method using radioactive chromium
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/10/01/
VL - 77
IS - Oct
SP - 527
EP - 531
SN - 00034819
AD - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1257; Language: English; Chemical Name: Chromium--7440-47-3; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents chromium; References: 17; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2 - An equation was derived which permits the recognition of Gilbert's syndrome from radioactive chromium (Cr-51) studies alone, of patients who have both hemolysis and Gilbert's syndrome.
KW - Chromium--Cr 51-;
KW - Radioisotopes--\SU/51\BS/Cr--diagnosis, of Gilbert's syndrome, in patients with hemolysis;
KW - Diagnostic agents--chromium--Cr 51, diagnosis of Gilbert's syndrome, in patients with hemolysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Deisseroth, A.;
AU - Morganroth, J.;
AU - Winokur, S.;
T1 - Quinidine-induced liver disease
CT - Quinidine-induced liver disease
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/10/01/
VL - 77
IS - Oct
SP - 595
EP - 597
SN - 00034819
AD - Reprints: National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
AD - Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts
N1 - Accession Number: 10-1213; Language: English; Chemical Name: Quinidine--56-54-2; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs quinidine; References: 3; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - Temperature, serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase, lactic dehydrogenase, alkaline phosphatase, and leucine aminopeptidase elevations were observed in a 77-year-old women during 2 separate periods of oral quinidine gluconate administration. The patient received 330 mg. of quinidine gluconate, every 8 hours orally and after 11 days the patient became febrile. Therapy was stopped and later reinstituted with the same results. Since all of these measurements returned to normal levels after discontinuing quinidine, it was concluded that quinidine had a direct toxic effect on the liver in this patient. This patient is the second known case of this toxic effect.
KW - Quinidine--gluconate-;
KW - Cardiac drugs--quinidine--gluconate, febrile reaction, case report;
KW - Drugs, adverse reactions--quinidine--gluconate, febrile reaction, case report;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Elfenbein, G.J.
AU - Shevach, E.M.
AU - Green, I.
T1 - Demonstration of Thymus-Derived Cell Surface Antigens on Various Guinea-Pig Lymphoid Cell Populations by a Micro-Immune Adherence Technique.
JO - Immunology
JF - Immunology
Y1 - 1972/10//
VL - 23
IS - 4
M3 - Article
SP - 523
EP - 535
PB - Wiley-Blackwell
SN - 00192805
AB - A micro-immune adherence assay employing direct microscopic observation was used to detect the presence of thymus-derived cell antigenic specificities on guinea-pig lymph node cells, purified peritoneal exudate lymphocytes, and thymocytes using a heterologous burro anti-guinea-pig thyrnocyte serum. A method is described for the direct determination of thymus-derived cell specificity of anti-lymphocyte sera. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE system
KW - BIOLOGICAL assay
KW - T cells
KW - CELL surface antigens
KW - LYMPHOID tissue
KW - GUINEA pigs as laboratory animals
KW - LYMPHOCYTES
KW - THYMUS
N1 - Accession Number: 13379187; Elfenbein, G.J. 1 Shevach, E.M. 1 Green, I. 1; Affiliation: 1: Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; Source Info: Oct72, Vol. 23 Issue 4, p523; Subject Term: IMMUNE system; Subject Term: BIOLOGICAL assay; Subject Term: T cells; Subject Term: CELL surface antigens; Subject Term: LYMPHOID tissue; Subject Term: GUINEA pigs as laboratory animals; Subject Term: LYMPHOCYTES; Subject Term: THYMUS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levine, S.
AU - Sowinski, R.
AU - Gruenewald, R.
AU - Kies, M.W.
T1 - Experimental Allergic Encephalomyelitis: PRODUCTION BY MYELIN BASIC PROTEIN ADSORBED ON PARTICULATE ADJUVANTS.
JO - Immunology
JF - Immunology
Y1 - 1972/10//
VL - 23
IS - 4
M3 - Article
SP - 609
EP - 614
PB - Wiley-Blackwell
SN - 00192805
AB - Aqueous solutions of myelin basic proteins do not cause allergic encephalomyelitis (EAE). They were rendered encephalitogenic for rats by admixture with kaolin, talc, glass, uncharged and cation exchange polystyrene resins, carbon and microspheres. Binding of basic protein to some of these aqueous particulate adjuvants was demonstrated spectrophotometrically. Absorption into the lymphatic system was demonstrated histologically. Binding of basic protein to adjuvant can occur in vivo. Basic protein was also bound by a carbon of relatively large particle size. Nevertheless, this carbon and certain other particulates failed to act as adjuvants, probably because they were not absorbed into the lymphatic system. An anion exchange resin, carbonyl iron, and some other particulates were abundantly absorbed into the lymphatic system but exhibited no adjuvant effect with basic protein, even though they do have an adjuvant effect for whole neural tissue. Their lack of effect with the purified antigen was explained by failure to bind basic protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGIC encephalomyelitis
KW - IMMUNOLOGICAL adjuvants
KW - MYELIN basic protein
KW - PROTEIN binding
KW - SPECTROPHOTOMETRY
KW - LYMPHATICS
KW - BASIC proteins
KW - CARBON
N1 - Accession Number: 13379394; Levine, S. 1 Sowinski, R. 1 Gruenewald, R. 1 Kies, M.W. 1; Affiliation: 1: Pathology Department, New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York and Section of Myelin Chemistry, National Institute of Mental Health, USA; Source Info: Oct72, Vol. 23 Issue 4, p609; Subject Term: ALLERGIC encephalomyelitis; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: MYELIN basic protein; Subject Term: PROTEIN binding; Subject Term: SPECTROPHOTOMETRY; Subject Term: LYMPHATICS; Subject Term: BASIC proteins; Subject Term: CARBON; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenberg, Nathan
T1 - MMPI ALCOHOLISM SCALES.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1972/10//
VL - 28
IS - 4
M3 - Article
SP - 515
EP - 522
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article obtains comparative validities for MMPI Alcoholism Scales. The sample was obtained from the VA Hospital, Fort Meade, South Dakota. The alcoholics consisted of 111 male veterans admitted both on a voluntary and on a commitment basis to a special treatment unit for alcoholics in which those with psychotic symptoms, other than those due to acute alcohol intoxication or to withdrawal from alcohol, were excluded. The Rosenberg Composite Scale consists of 6 MMPI items common to all three of the most promising scales, as well as 21 items common to two scales.
KW - PSYCHIATRIC rating scales
KW - ALCOHOLICS
KW - ALCOHOLISM -- Treatment
KW - SUBSTANCE abuse
KW - VETERANS
KW - SOCIAL science research
KW - ALCOHOL use
KW - FORT Meade (S.D.)
N1 - Accession Number: 15866611; Rosenberg, Nathan 1; Affiliation: 1: National Institute on Alcohol Abuse and Alcoholism.; Source Info: Oct1972, Vol. 28 Issue 4, p515; Subject Term: PSYCHIATRIC rating scales; Subject Term: ALCOHOLICS; Subject Term: ALCOHOLISM -- Treatment; Subject Term: SUBSTANCE abuse; Subject Term: VETERANS; Subject Term: SOCIAL science research; Subject Term: ALCOHOL use; Subject Term: FORT Meade (S.D.); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Tauraso, N.;
AU - Myers, M.;
AU - Nau, E.;
AU - O'Brien, T.;
AU - Spindel, S.;
AU - \ET/;
T1 - Effect of interval between inoculation of live smallpox and yellow fever vaccines on antigenicity in man
CT - Effect of interval between inoculation of live smallpox and yellow fever vaccines on antigenicity in man
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1972/10/01/
VL - 126
IS - Oct
SP - 362
EP - 371
SN - 00221899
AD - Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-2183; Language: English; References: 23; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - In the first part of this study, volunteers were initially given smallpox vaccine; yellow fever vaccine was given to groups of these volunteers simultaneously, and 3, 7, 14, and 28 days later; Part two was essentially the same, except that yellow fever vaccine was administered initially, and the time of smallpox vaccination varied as indicated above. The results showed that the reactogenicity and antigenicity of live smallpox and yellow fever vaccines were unaffected by the interval between inoculations. The advantages of administering live virus vaccines, either simultaneously or at different times, were evaluated. It was suggested that the recommendations on immunization with smallpox and yellow fever vaccines be modified in light of the findings of this study.
KW - Smallpox vaccines--dosage schedules-;
KW - Yellow fever vaccines--dosage schedules-;
KW - Dosage schedules--smallpox vaccines--and yellow fever vaccines, effect of interval between inoculation on antigenicity in man;
KW - Immunization--smallpox--and yellow fever, effect of interval between inoculation on antigenicity in man;
KW - Immunization--yellow fever--and smallpox, effect of interval between inoculation on antigenicity in man;
KW - Drug interactions--smallpox and yellow fever vaccines--lack, effect of interval between inoculation on antigenicity in man;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stripp, B.;
AU - Gillette, J. R.;
T1 - Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity
CT - Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/10/01/
VL - 61
IS - Oct
SP - 1682
EP - 1685
SN - 00223549
AD - Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Besthesda, Maryland 20014
N1 - Accession Number: 11-4718; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Pharmacology
KW - Metabolism--drugs--factors affecting pharmacology and toxicity;
KW - Toxicity--drugs--metabolism, factors affecting;
KW - Research--drugs--metabolism, factors affecting pharmacology and toxicity;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-41458-019
AN - 2013-41458-019
AU - Shore, Milton F.
T1 - Review of Adolescent psychiatry, Vol. I: Developmental and clinical studies, Adolescence, Teaching and learning adolescent psychiatry, and Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1972/10//
VL - 42
IS - 5
SP - 884
EP - 887
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41458-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Psychiatry; Mental Health Personnel; Professional Organizations; Psychiatric Training; Scientific Communication. Minor Descriptor: Teaching. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Feinstein, Sherman C. (Ed); Giovacchini, Peter (Ed); Miller, Arthur A. (Ed). Adolescent psychiatry, Vol. 1: Developmental and clinical studies=New York: Basic Books. 552 pp. $15.00; 1971. Josselyn, Irene M. Adolescence=New York: Harper & Row. 213 pp. $5.95; 1971. Offer, Daniel (Ed); Masterson, John F. (Ed). Teaching and learning adolescent psychiatry=Springfield, III.: Charles C. Thomas. 157 pp. $9.50; 1971. No authorship indicated. Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971=Washington, D.C.: U.S. Government Printing Office. $2.50; 1971. Page Count: 4. Issue Publication Date: Oct, 1972.
AB - Reviews the books, Adolescent Psychiatry, Vol. I: Developmental and clinical studies edited by Sherman C. Feinstein, Peter Giovacchini and Arthur A. Miller (1971), Adolescence by Irene M. Josselyn (1971) Teaching and Learning Adolescent Psychiatry edited by Daniel Offer and John F. Masterson (1971) and Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971 (1971). The three psychiatric books are collections of papers by well-known mental health professionals; the White House Conference was a planned attempt to involve some 1,000 adolescents with a wide range of backgrounds and interests, with 500 'older' professionals to work together and reflect on both the current problems of the society and the problems in which youth themselves are directly involved. Keniston, in an excellent article in the Feinstein book, describes the set of historical and social circumstances that has given rise to a new recognition of adolescence and youth as distinct parts of the life cycle. Dommermuth, in the Offer book, discusses the sociological forces that take over when a new field is identified. A professional organization arises, which then sponsors publications. Despite their constant references to Erikson, the three psychiatric books do not adequately meet his standards. The White House Conference Report, on the other hand, seems to be a refreshing step in that direction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent psychiatry
KW - White House Conference
KW - professional organizations
KW - mental health professionals
KW - psychiatry teaching
KW - psychiatry learning
KW - 1972
KW - Adolescent Psychiatry
KW - Mental Health Personnel
KW - Professional Organizations
KW - Psychiatric Training
KW - Scientific Communication
KW - Teaching
KW - 1972
U2 - Feinstein, Sherman C. (Ed); Giovacchini, Peter (Ed); Miller, Arthur A. (Ed). (1971); Adolescent psychiatry, Vol. 1: Developmental and clinical studies; New York: Basic Books. 552 pp. $15.00
U2 - Josselyn, Irene M. (1971); Adolescence; New York: Harper & Row. 213 pp. $5.95
U2 - Offer, Daniel (Ed); Masterson, John F. (Ed). (1971); Teaching and learning adolescent psychiatry; Springfield, III.: Charles C. Thomas. 157 pp. $9.50
U2 - No authorship indicated. (1971); Report of the White House Conference on Youth: Estes Park, Colorado, April 18–21, 1971; Washington, D.C.: U.S. Government Printing Office. $2.50
DO - 10.1111/j.1939-0025.1972.tb00775.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LEVITAN, HERBERT
AU - BARKER, JEFFERY L.
T1 - Membrane Permeability: Cation Selectivity Reversibly Altered by Salicylate.
JO - Science
JF - Science
Y1 - 1972/10/06/
VL - 178
IS - 4056
M3 - Article
SP - 63
EP - 64
SN - 00368075
AB - The effect of salicylate on the relative cation permeability of a membrane was investigated in large, identified molluscan neurons, with the use of intracellular recording techniques. Salicylate caused a reversible, dose-dependent decrease in the permeability of rubidium, cesium, sodium, and lithium ions relative to that of potassium ions. The results suggest that the changes in cation selectivity result from the adsorption of salicylate anions to the membrane with a subsequent increase in the density and field strength of anionic sites in the membrane. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519085; LEVITAN, HERBERT 1; BARKER, JEFFERY L. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p63; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KNAZEK, RICHARD A.
AU - GULLINO, PIETRO M.
AU - KOHLER, PETER O.
AU - DEDRICK, ROBERT L.
T1 - Cell Culture on Artificial Capillaries: An Approach to Tissue Growth in vitro.
JO - Science
JF - Science
Y1 - 1972/10/06/
VL - 178
IS - 4056
M3 - Article
SP - 65
EP - 67
SN - 00368075
AB - Artificial capillaries perfused with culture medium provide a matrix in which cells can attain tissue-like densities in vitro. Products secreted into the medium can be measured as indicators of cell function or may be recovered for other purpose without disturbing the culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519083; KNAZEK, RICHARD A. 1; GULLINO, PIETRO M.; KOHLER, PETER O.; DEDRICK, ROBERT L.; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p65; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - THOA, N. B.
AU - EICHELMAN, B.
AU - RICHARDSON, J. S.
AU - JACOBOWITZ, D.
T1 - 6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior.
JO - Science
JF - Science
Y1 - 1972/10/06/
VL - 178
IS - 4056
M3 - Article
SP - 75
EP - 77
SN - 00368075
AB - A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519104; THOA, N. B. 1; EICHELMAN, B. 1; RICHARDSON, J. S. 1; JACOBOWITZ, D. 1; Affiliations: 1: Laboratories of Clinical Science and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 10/6/1972, Vol. 178 Issue 4056, p75; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Howard, W. A.;
AU - Collins, W. E.;
T1 - Heparin therapy in simian Plasmodium knowlesi malaria
CT - Heparin therapy in simian Plasmodium knowlesi malaria
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1972/10/07/
VL - 2
IS - Oct 7
SP - 738
EP - 739
SN - 00237507
AD - Primate Malaria Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, P.O. Box 80190, Chamblee, Georgia 30341
N1 - Accession Number: 10-2826; Language: English; Chemical Name: Heparin--9005-49-6; Therapeutic Class: (20:12.04); AHFS Class: Anticoagulants heparin; References: 14; Journal Coden: LANCAO; Section Heading: Drug Evaluations
N2 - Intravenous heparin (450 units/kg. every 8 hours or 500 units/kg. every 6 hours) had no antimalarial activity against Plasmodium knowlesi malaria in monkeys. The survival of infected monkeys was not influenced by 450 units of heparin/kg. administered I.V. every 8 hours. Disseminated intravascular coagulation, therefore, does not seem to be the major cause of death in these animals. Routine use of heparin in complicated falciparum malaria in man must await controlled studies which demonstrate efficacy.
KW - Heparin--malaria-;
KW - Anticoagulants--heparin--malaria, Plasmodium knowlesi, lack, effect, in monkeys;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - CATTABENI, F.
AU - KoSLOW, S. H.
AU - COSTA, E.
T1 - Gas Chromatographic-Mass Spectrometric Assay of Four Indole Alkylamines of Rat Pineal.
JO - Science
JF - Science
Y1 - 1972/10/13/
VL - 178
IS - 4057
M3 - Article
SP - 166
EP - 168
SN - 00368075
AB - Gas chromatography-mass spectromnetry was used to quantitate serotonin, N-acetylserotonin, 5-methoxytryptamine, and melatonin in single rat pineal glands. After gas chromatographic separation, the ion density of specific fragments of each indole was measured with mass spectrometry. Sensitivity of this indole assay is of the order of 10-12 to 10-13 mole. Routinely, specificity is based on gas chromatographic retention time and the recording of the ion density generated by specific fragments. Absolute identification of the extracted indoles was based on multiple ion detection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138509; CATTABENI, F. 1; KoSLOW, S. H. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 10/13/1972, Vol. 178 Issue 4057, p166; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAVIN III, JAMES R.
AU - BUELL, DONALD N.
AU - ROTH, JESSE
T1 - Water-Soluble Insulin Receptors from Human Lymphocytes secondreported in intact cells.
JO - Science
JF - Science
Y1 - 1972/10/13/
VL - 178
IS - 4057
M3 - Article
SP - 168
EP - 169
SN - 00368075
AB - Specific insulin receptors from human lymphocytes in culture have been prepared in aqueous solution without use of detergents or related compounds. Receptors prepared in this fashion exhibit characteristics identical to those [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138510; GAVIN III, JAMES R. 1; BUELL, DONALD N. 2; ROTH, JESSE 3; Affiliations: 1: Section on Diabetes and Intermediary Metabolism, Clinical Endocrinology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 2: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Section on Diabetes and Intermediary Metabolism, National Institute of Arthritis, Metabolism, and Digestive Diseases Bethesda, Maryland 20014; Issue Info: 10/13/1972, Vol. 178 Issue 4057, p168; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Larson, S. M.;
AU - Graff, K. S.;
AU - Tretner, I.-H.;
AU - Zager, R. F.;
AU - Henderson, E. A.;
AU - \ET/;
T1 - Positive gallium 67 photoscan in myeloblastoma
CT - Positive gallium 67 photoscan in myeloblastoma
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/10/16/
VL - 222
IS - Oct 16
SP - 321
EP - 323
AD - Building 10, Room 1B53, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1046; Language: English; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals gallium citrate; References: 3; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Case summaries are presented on 2 patients in whom myeloblastomas of the breast were detected by gallium citrate Ga 67 photoscanning.
KW - Gallium citrate--Ga 67-;
KW - Radiopharmaceuticals--gallium citrate--Ga 67, photoscans, myeloblastoma detection, case reports;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BASTIAN, F. O.
AU - RABSON, A. S.
AU - YEE, C. L.
AU - TRALKA, T. S.
T1 - Herpesvirus hominis: Isolation from Human Trigeminal Ganglion.
JO - Science
JF - Science
Y1 - 1972/10/20/
VL - 178
IS - 4058
M3 - Article
SP - 306
EP - 307
SN - 00368075
AB - Herpesvirus hominis was isolated from the trigeminal ganglion obtained at autopsy from 1 of 22 patients with no clinical evidence of active herpetic disease, and from one patient with malignant lymphoma who died with herpes zoster on the abdomen, pulmonary cytomegalic inclusion disease, and possible oral herpes simplex. Virus was isolated by cocultivation of explants of ganglion with monolayers of Vero green monkey kidney cells and required 3 weeks of culture before viral cytopathic eflects were evident. These observations support the concept that latent infection of sensory ganglia may be the sotirce of virus in recurrent herpetic disease in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546778; BASTIAN, F. O. 1; RABSON, A. S. 1; YEE, C. L. 1; TRALKA, T. S. 1; Affiliations: 1: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/20/1972, Vol. 178 Issue 4058, p306; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bagley, C. M., Jr.;
AU - Young, R. C.;
AU - Canellos, G. P.;
AU - DeVita, V. T.;
T1 - Treatment of ovarian carcinoma: possibilities for progress
CT - Treatment of ovarian carcinoma: possibilities for progress
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/10/26/
VL - 287
IS - Oct 26
SP - 856
EP - 862
SN - 00284793
AD - Medicine Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, Bethesda, Maryland 20014
N1 - Accession Number: 10-1781; Language: English; References: 53; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Joan Lentine
N2 - Classification of ovarian adenocarcinoma, and modes of therapy such as surgery, radiotherapy, chemotherapy, and a combination of radiotherapy and chemotherapy are discussed. Alkylating agents discussed are melphalan, chlorambucil, cyclophosphamide, and triethylene-thiophosphoramide (thiotepa). Other chemotherapeutic agents (nonalkylating) discussed are fluorouracil, methotrexate, hexamethylmelamine, vinblastine, diethylstilbestrol and hydroxyprogesterone.
KW - Antineoplastic agents--carcinoma--ovarian, therapy, discussion;
KW - Cancer--ovarian--antineoplastic agents, therapy, discussion;
KW - Combined therapy--antineoplastic agents--cancer, ovarian, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Becker, Edwin D.
AU - Farrar, T. C.
T1 - Fourier Transform Spectroscopy.
JO - Science
JF - Science
Y1 - 1972/10/27/
VL - 178
IS - 4059
M3 - Article
SP - 361
EP - 368
SN - 00368075
N1 - Accession Number: 85158185; Becker, Edwin D. 1; Farrar, T. C. 2; Affiliations: 1: Chief, Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Director, Research and Development, JEOL, Inc., Cranford, New Jersey 07016; Issue Info: 10/27/1972, Vol. 178 Issue 4059, p361; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Carter, S. K.;
T1 - New drugs on the horizon in bronchogenic carcinoma
CT - New drugs on the horizon in bronchogenic carcinoma
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1972/11/01/
VL - 30
IS - Nov
SP - 1402
EP - 1409
AD - Cancer Therapy Evaluation Branch, Chemotherapy Program, National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 11-2637; Language: English; Trade Name: BCNU--CCNU--NSC-102816--NSC-109724--NSC-129943--NSC-119875--Adriamycin--Iphosphamide--ICRF-159; Generic Name: Carmustine; Lomustine; 5-Azacytidine; Isophosphamide; Razoxane; cis-Diaminedichloroplatinum; Doxorubicin; Isophosphamide; Razoxane; Chemical Name: Carmustine--154-93-8 Lomustine--13010-47-4 Doxorubicin--23214-92-8 Bleomycin--11056-06-7 Razoxane--21416-87-5; References: 57; Journal Coden: CANCARCANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A discussion of preliminary testing of a variety of antineoplastic agents, using lung cancer patients in the clinical trials, is presented. Among the new drugs sponsored for trial, which have shown evidence of activity against lung cancer, are the nitrosoureas, of which 3 are in various stages of clinical evaluation. Carmustine (BCNU) has shown activity in 9/83 (11%) while lomustine (CCNU) has shown activity in 11/52 (21%). The newest analog, methyl CCNU, is of great interest because of its superior activity against the advanced Lewis lung tumor. Other new agents which have shown some evidence of activity include adriamycin (30/147; doxorubicin), hexamethylmelamine (42/202), and bleomycin (5/62). Among the new drugs just completing phase I evaluation and awaiting trial in lung cancer are: iphosphamide (NSC-109724; isophosphamide), ICRF-159 (NSC-129943; razoxane), 5-azacytidine (NSC-102816), and cis-diaminedichloroplatinum (NSC-119875).
KW - Carmustine--cancer-;
KW - Lomustine--cancer-;
KW - Lomustine--methyl-;
KW - Hexamethylmelamine--cancer-;
KW - Doxorubicin--cancer-;
KW - Bleomycin--cancer-;
KW - Isophosphamide--antineoplastic agents-;
KW - Razoxane--antineoplastic agents-;
KW - 5-Azacytidine--antineoplastic agents-;
KW - cis-Diaminedichloroplatinum--antineoplastic agents-;
KW - Antineoplastic agents--cancer--lung, preliminary trials of investigational drugs, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Greene, W.;
AU - Huffman, D.;
AU - Wiernik, P. H.;
AU - Schimpff, S.;
AU - Benjamin, R.;
AU - \ET/;
T1 - High-dose daunorubicin therapy for acute nonlymphocytic leukemia: correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity
CT - High-dose daunorubicin therapy for acute nonlymphocytic leukemia: correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1972/11/01/
VL - 30
IS - Nov
SP - 1419
EP - 1427
AD - Medicine and Biochemistry Sections of the Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 11-2261; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 25; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Daunorubicin (daunomycin), administered in large doses intermittently to 23 patients with acute nonlymphocytic leukemia, produced a complete hematologic remission rate of 33%. Five of 16 (31%) previously untreated patients achieved complete hematologic remission. Clinical response was closely correlated with in vitro determinations of peripheral leukemic myeloblast daunorubicin reductase activity. The measurement of the activity of daunorubicin reductase in peripheral myeloblasts from patients prior to therapy may serve to identify those patients least likely to respond favorably to daunorubicin therapy in the dose and schedule used in this study.
KW - Daunomycin--leukemias-;
KW - Antineoplastic agents--daunomycin--leukemias, acute nonlymphocytic, correlation of response to myeloblast reductase activity, in patients;
KW - Pharmacokinetics--daunomycin--leukemias, acute nonlymphocytic, correlation of response to myeloblast reductase activity, in patients;
KW - Dosage--daunomycin--high, acute nonlymphocytic leukemia therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Catalona, W. J.
AU - Taylor, P. T.
AU - Chretien, P. B.
T1 - QUANTITATIVE DINITROCHLOROBENZENE CONTACT SENSITIZATION IN A NORMAL POPULATION.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/11//
VL - 12
IS - 3
M3 - Article
SP - 325
EP - 333
PB - Wiley-Blackwell
SN - 00099104
AB - Using a quantitative method based on the sponteneous flare phenomenon, contact sensitization to DNCB was studied in 143 healthy volunteers between the ages of 20 and 80 yr. A spontaneous flare reaction occurred in 965% of subjects tested, regardless of age, and a correlation was demonstrated between the intensity of the primary response to DNCB and the threshold dose of DNCB required to elicit an anamnestic response. The results are in striking contrast to a 40% incidence of spontaneous flare reactions previously found in cancer patients using the same method. These findings show that this method of assaying reactivity to DNCB detects abnormalities of cell-mediated immunity not demonstrated by qualitative methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DINITROCHLOROBENZENE
KW - CHLOROBENZENE
KW - CONTACT dermatitis
KW - CELLULAR immunity
KW - CANCER patients
KW - IMMUNE response
N1 - Accession Number: 14545688; Catalona, W. J. 1 Taylor, P. T. 1 Chretien, P. B. 1; Affiliation: 1: Surgery Branch, National Cancer Institute, National Cancer Institute, N.I.H., Bethesda, U.S.A.; Source Info: Nov72, Vol. 12 Issue 3, p325; Subject Term: DINITROCHLOROBENZENE; Subject Term: CHLOROBENZENE; Subject Term: CONTACT dermatitis; Subject Term: CELLULAR immunity; Subject Term: CANCER patients; Subject Term: IMMUNE response; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Powell, Deborah E.
AU - Steinberg, A. D.
T1 - THE PATHOGENESIS OF AUTOIMMUNITY IN NEW ZEALAND MICE.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/11//
VL - 12
IS - 3
M3 - Article
SP - 419
EP - 427
PB - Wiley-Blackwell
SN - 00099104
AB - New Zealand mice spontaneously develop antibodies to double-stranded RNA and DNA. The appearance of these antibodies is accelerated by the administration of the synthetic double-stranded RNA, polyinosinic polycytidylic acid (poly I ˙ poly C). Since poly I ˙ poly C is known to act both as a nucleic acid antigen and as an adjuvant, the mechanism of nucleic acid antibody stimulation was studied to determine which property of poly I ˙ poly C was operative. NZB/NZW mice were made tolerant to poly I ˙ poly C as an antigen with cyclophosphamide. They were then given 10 pg or 150 pg of poly I ˙ poly C three times per week. Tolerant mice given 10 pg of poly I ˙ poly C had acceleration of anti- bodies to DNA but not RNA. In this case the stimulation of antibodies to DNA appeared to represent the adjuvant property of poly I ˙ poly C. Since non-tolerant but not tolerant mice had stimulation of antibodies to RNA with 10 pg poly I ˙ poly C, this anti-RNA acceleration appears to represent antigenic stimulation. All animals given 150 pg poly I ˙ poly C had stimulation of antibodies to both RNA and DNA, suggesting a predominently adjuvant mechanism. The possible role of antigenic and adjuvant properties of nucleic acids in the natural disease of New Zealand mice is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE as laboratory animals
KW - IMMUNOGLOBULINS
KW - RNA
KW - DNA
KW - AUTOANTIBODIES
KW - INTERFERON inducers
KW - BIOMOLECULES
N1 - Accession Number: 14545706; Powell, Deborah E. 1 Steinberg, A. D. 2; Affiliation: 1: Department of Pathology, Georgetown University Medical Center, Washington, D.C. 2: Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov72, Vol. 12 Issue 3, p419; Subject Term: MICE as laboratory animals; Subject Term: IMMUNOGLOBULINS; Subject Term: RNA; Subject Term: DNA; Subject Term: AUTOANTIBODIES; Subject Term: INTERFERON inducers; Subject Term: BIOMOLECULES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Huffman, D. H.;
AU - Benjamin, R. S.;
AU - Bachur, N. R.;
T1 - Daunorubicin metabolism in acute nonlymphocytic leukemia
CT - Daunorubicin metabolism in acute nonlymphocytic leukemia
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1972/11/01/
VL - 13
IS - Nov-Dec
SP - 895
EP - 905
SN - 00099236
AD - Biochemistry Section, Baltimore Cancer Research Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-1969; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 26; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2 - The pharmacokinetic evaluation of daunorubicin (daunomycin) and its principal human metabolites, daunorubicinol and 2 previously unidentified metabolites, has provided information concerning the in vivo metabolism of daunorubicin in patients with acute nonlymphocytic leukemia. Daunorubicinol was the major fluorescent material present in plasma and urine and was a significant metabolite in the tissues. For 8 patients, the mean plasma half-lives of daunorubicin and daunorubicinol were 18.5 4.86 hours and 26.7 12.8 hours, respectively. In 4 of these patients the plasma half-lives of daunorubicin and daunorubicinol were equal, indicating a variability of the pharmacokinetics in different individuals. These observations together with the earlier demonstration of increased production of daunorubicinol in vitro by leukemic leukocytes from responding patients indicate a significant role for daunorubicinol in the pharmacodynamics of daunorubicin therapy. One of the new metabolites, D5, was the predominant fluorescent material in human heart.
KW - Daunomycin--pharmacokinetics-;
KW - Antineoplastic agents--daunomycin--pharmacokinetics, in acute nonlymphocytic leukemia patients;
KW - Metabolism--daunomycin--half-life, blood levels, in acute nonlymphocytic leukemia patients;
KW - Blood levels--daunomycin--half-life, in acute nonlymphocytic leukemia patients;
KW - Half-life--daunomycin--blood levels, in acute nonlymphocytic leukemia patients;
KW - Pharmacokinetics--daunomycin--blood levels and half-life, in acute nonlymphocytic leukemia patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Song, C. S.;
AU - Gelb, N. A.;
AU - Wolff, S. M.;
T1 - Influence of pyrogen-induced fever on salicylamide metabolism in man
CT - Influence of pyrogen-induced fever on salicylamide metabolism in man
JO - J. Clin. Invest.
JF - J. Clin. Invest.
Y1 - 1972/11/01/
VL - 51
IS - Nov
SP - 2959
EP - 2966
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 10-3746; Language: English; Chemical Name: Salicylamide--65-45-2; References: 43; Journal Coden: JCINAOJONAO; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Marcia S. Jacinto
N2 - Salicylamide metabolism was studied in 18 normal volunteers (14 men, 4 women) before and after induction of artificial fever by administration of etiocholanolone or endotoxin. There was a significant reduction in the half-life of the excretion of the drug metabolites, probably due to increased hepatic and renal blood flow during episodes of pyrogen-induced fever. No simple explanation exists to account for the altered pattern of urinary salicylamide metabolites, wherein there is a proportionate decrease in the major metabolite (salicylamide glucuronide) with a concomitant increase in the proportion of one or both of the other metabolites (salicylamide sulfate and gentisamide glucuronide). These metabolic effects are attributed to the multiple, complex interactions between the effects of pyrogens, fever, or certain physiological or bichemical changes associated with them on the one hand, and the factors affecting the hepatic metabolism of salicylamide on the other.
KW - Salicylamide--metabolism-;
KW - Half-life--salicylamide--decreased, by pyrogen induced fever, in humans;
KW - Metabolism--salicylamide--effects, pyrogen induced fever, in humans;
KW - Excretion--salicylamide--effects, pyrogen induced fever, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Robbins, Jay H.
AU - Levis, William R.
AU - Miller, A. Edgar
T1 - XERODERMA PIGMENTOSUM EPIDERMAL CELLS WITH NORMAL UV-INDUCED THYMIDINE INCORPORATION.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1972/11//
VL - 59
IS - 5
M3 - Article
SP - 402
EP - 408
SN - 0022202X
AB - Ultraviolet light-induced thymidine incorporation was measured in trypsin-dissociated epidermal cells from two patients with xeroderma pigmentosum (XP) and from control donors. Results paralleled those obtained with lymphocytes and fibroblasts in that the patient with a repair defect in these cells also had the defect in her epidermal cells. The other patient, previously shown to have no detectable repair defect in his lymphocytes or fibroblasts, appeared also to have normal DNA repair in his epidermal cells despite the presence of severe clinical manifestations of XP in this tissue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - XERODERMA pigmentosum
KW - PHOTOSENSITIVITY disorders
KW - DENDRITIC cells
KW - THYMIDINE
KW - FIBROBLASTS
KW - DNA
N1 - Accession Number: 12627528; Robbins, Jay H. 1 Levis, William R. 1 Miller, A. Edgar 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Source Info: Nov72, Vol. 59 Issue 5, p402; Subject Term: XERODERMA pigmentosum; Subject Term: PHOTOSENSITIVITY disorders; Subject Term: DENDRITIC cells; Subject Term: THYMIDINE; Subject Term: FIBROBLASTS; Subject Term: DNA; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12627528
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NEUFELD, ELIZABETH F.
AU - SWEELEY, CHARLES C.
AU - ROGERS, STANFIELD
AU - FRIEDMANN, THEODORE
AU - ROBLIN, RICHARD
T1 - Gene Therapy for Human Genetic Disease?
JO - Science
JF - Science
Y1 - 1972/11/10/
VL - 178
IS - 4061
M3 - Article
SP - 648
EP - 649
SN - 00368075
N1 - Accession Number: 85138563; NEUFELD, ELIZABETH F. 1; SWEELEY, CHARLES C. 2; ROGERS, STANFIELD 3; FRIEDMANN, THEODORE 4; ROBLIN, RICHARD 5; Affiliations: 1: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Biochemistry, Michigan State University, East Lansing 48823; 3: Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830; 4: Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla 92037; 5: Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts 02114; Issue Info: 11/10/1972, Vol. 178 Issue 4061, p648; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FARLEY, C. AUSTIN
AU - BANFIELD, WILLiAM G.
AU - KASNIC JR., GEORGE
AU - FOSTER, WALTER S.
T1 - Oyster Herpes-Type Virus.
JO - Science
JF - Science
Y1 - 1972/11/17/
VL - 178
IS - 4062
M3 - Article
SP - 759
EP - 760
SN - 00368075
AB - A herpes-type virus infection, the first to be found in an invertebrate animal, is reported in the oyster Crassostrea virginica. Intranuclear herpes-type viral inclusions were more prevalent in the oyster at elevated water temperatures of 280 to 30°C than at normal ambient temperatures of 18' to 20°C. The inclusions were associated with a lethal disease at the elevated temperatures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138595; FARLEY, C. AUSTIN 1; BANFIELD, WILLiAM G. 2; KASNIC JR., GEORGE 2; FOSTER, WALTER S. 3; Affiliations: 1: National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Middle Atlantic Coastal Fisheries Center, Oxford Laboratory, Oxford, Maryland 21654; 2: National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20014; 3: Hatchet Cove, Friendship, Maine 04547; Issue Info: 11/17/1972, Vol. 178 Issue 4062, p759; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROWE, WALLACE P.
AU - HARTLEY, JANET W.
AU - BREMNER, THEODORE
T1 - Genetic Mapping of a Murine Leukemia Virus-Inducing Locus of AKR Mice.
JO - Science
JF - Science
Y1 - 1972/11/24/
VL - 178
IS - 4063
M3 - Article
SP - 860
EP - 862
SN - 00368075
AB - The chromosomal location of one of the two murine leukemia virusinducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-l-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-l locus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138627; ROWE, WALLACE P. 1; HARTLEY, JANET W. 1; BREMNER, THEODORE 2; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Department of Botany, Howard University, Washington, D.C. 20001; Issue Info: 11/24/1972, Vol. 178 Issue 4063, p860; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Grenne, W. H.;
AU - Wiernik, P. H.;
T1 - Candida endophthalmitis. Successful treatment in a patient with acute leukemia
CT - Candida endophthalmitis. Successful treatment in a patient with acute leukemia
JO - Am. J. Ophthalmol.
JF - Am. J. Ophthalmol.
Y1 - 1972/12/01/
VL - 74
IS - Dec
SP - 1100
EP - 1102
AD - National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland 21211
N1 - Accession Number: 10-3079; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 18; Journal Coden: AJOPAA; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Howard J. Robbins
N2 - A case of candida endophthalmitis is reported in a patient under treatment for acute leukemia; therapy with I.V. amphotericin B was successful despite the occurence of bone marrow relapse.
KW - Amphotericin B--endophthalmitis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kleinman, L. M.;
AU - Tangrea, J. A.;
AU - Hiranaka, P. K.;
T1 - Preparation and assay of 2,4-dinitrochlorobenzene in acetone
CT - Preparation and assay of 2,4-dinitrochlorobenzene in acetone
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1972/12/01/
VL - 29
IS - Dec
SP - 1041
EP - 1042
SN - 00029289
AD - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-2878; Language: English; Trade Name: 1-Chloro-2,4-dinitrobenzene; Generic Name: 2,4-Dinitrochlorobenzene; Chemical Name: 2,4-Dinitrochlorobenzene--97-00-7; References: 6; Publication Type: Assay and quality control; Journal Coden: AJHPA9; Section Heading: Pharmaceutics
N2 - The preparation and assay of 2,4-dinitrochlorobenzene (1-chloro-2,4-dinitrobenzene) solution in acetone are discussed. The chemical is used in a quantitative measurement of cell mediated immune responses. A packaging system was developed to increase the shelf life of the solution to 6 months.
KW - 2,4-Dinitrochlorobenzene--solutions-;
KW - Analysis--2,4-dinitrochlorobenzene--solutions, in acetone, and preparation;
KW - Packaging--2,4-dinitrochlorobenzene--solutions, in acetone, increases shelf life;
KW - Stability--2,4-dinitrochlorobenzene--solutions, in acetone, shelf life increased by packaging system;
KW - Formulations--2,4-dinitrochlorobenzene--solutions, in acetone, and analysis;
KW - Storage--2,4-dinitrochlorobenzene--solutions, acetone, package increases shelf life;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Canellos, G. P.;
AU - Moxley, J. H.;
T1 - Decade of combination chemotherapy of advanced Hodgkin's disease
CT - Decade of combination chemotherapy of advanced Hodgkin's disease
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1972/12/01/
VL - 30
IS - Dec
SP - 1495
EP - 1504
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland
N1 - Accession Number: 11-2129; Language: English; Trade Name: Oncovin; Generic Name: Vincristine; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, mechlorethamine, prednisone and procarbazine (10:00); AHFS Class: Antineoplastic agents procarbazine, mechlorethamine, prednisone and vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 35; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - A review of the various forms of combination therapy in the treatment of Hodgkin's disease over the last decade is presented. Combinations of vinca alkaloids, alkylating agents, prednisone and methotrexate were encouraging enough to lead to an expanded program substituting procarbazine for methotrexate. This combined drug program (mechlorethamine, Oncovin [vincristine], prednisone and procarbazine; MOPP) 9 years later has yielded results significantly different than those previously achieved with single agents. The results of this program and of several other studies employing combinations of effective drugs consistently show a higher rate of induction of complete remissions in patients with advanced Hodgkin's disease (80%) and prolongation of remission duration after all therapy is stopped (36 months). These results have been confirmed in several cooperative trials. Approximately 70% of the patients with Stages III and IV disease who achieved remission with combination chemotherapy, between 1964 and 1967, are alive at 5 and 6 years. Forty-one per cent of complete responders have remained continuously free of disease with no further treatment up to 6 years. The complete remission rate alone should not be used to judge the effectiveness of new treatment programs. These therapies should also be evaluated by their ability to produce a long disease-free interval when all therapy is stopped.
KW - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW - Prednisone--mechlorethamine, procarbazine, and vincristine-;
KW - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW - Methotrexate--Hodgkin's disease-;
KW - Hodgkin's disease--combined therapy--review;
KW - Antineoplastic agents--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, review;
KW - Antineoplastic agents--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, review;
KW - Antineoplastic agents--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, review;
KW - Antineoplastic agents--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, review;
KW - Antineoplastic agents--methotrexate--Hodgkin's disease, replacement with procarbazine in MOPP therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carbone, P. P.;
T1 - Non-Hodgkin's lymphoma: recent observations on natural history and intensive treatment
CT - Non-Hodgkin's lymphoma: recent observations on natural history and intensive treatment
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1972/12/01/
VL - 30
IS - Dec
SP - 1511
EP - 1516
AD - Building 10, Room 6B15, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-2131; Language: English; References: 19; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - A discussion of the etiology and chemotherapy of non-Hodgkin's lymphomas is presented. Included in this classification are lymphocytic, histiocytic, pleomorphic and Burkett's lymphomas. The disease is more likely to be advanced and present with extranodal involvement. The results of therapy depend on the cell type; histologic pattern, diffuse or nodular; and the type of involvement, nodal vs. extranodal. The results of intensive chemotherapy have significantly increased the proportion of complete responders and the duration of complete remissions as compared to single agents. Several new agents offer promise of other combination therapy programs.
KW - Antineoplastic agents--lymphomas--non-Hodgkin's, etiology and therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
T1 - Chemotherapeutic management of the hormone-secreting endocrine malignancies
CT - Chemotherapeutic management of the hormone-secreting endocrine malignancies
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1972/12/01/
VL - 30
IS - Dec
SP - 1616
EP - 1626
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland
N1 - Accession Number: 11-2213; Language: English; Chemical Name: Mitotane--53-19-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin (10:00); AHFS Class: Antineoplastic agents mitotane; References: 84; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A review of the medical management of metastatic endocrine tumors, including clinical results of streptozotocin in malignant insulinomas and mitotane in adrenocortical carcinomas is presented. Use of both antineoplastic agents and antihormonal agents are included. The former is directed against the primary tumor and its metastases, while the latter offers palliation through the inhibition of synthesis, release, or direct cellular action of the specific secretory product.
KW - Mitotane--carcinomas-;
KW - Streptozotocin--insulinomas-;
KW - Antineoplastic agents--streptozotocin--insulinomas, malignant, therapy, review;
KW - Antineoplastic agents--mitotane--carcinomas, adrenocortical, therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Chused, T. M.
AU - Steinberg, A. D.
AU - Talal, N .
T1 - THE CLEARANCE AND LOCALIZATION OF NUCLEIC ACIDS BY NEW ZEALAND AND NORMAL MICE.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/12//
VL - 12
IS - 4
M3 - Article
SP - 465
EP - 476
PB - Wiley-Blackwell
SN - 00099104
AB - The clearance and localization of native DNA, denatured DNA, and doublestranded synthetic RNA was studied in New Zealand Black/White hybrid mice, which develop an illness closely resembling human systemic lupus erythematosus, a n d in normal mice. The three nucleic acids were rapidly cleared from the circulation in all strains studied. Serum nucleases did not account for this rapid clearance, indicating that the nucleic acids were taken up as macromolecules. The polymers were concentrated in the liver and spleen, suggesting uptake by the reticulo-endothelial system. Animals with circulating antibody cleared the nucleic acids even more rapidly. New Zealand mice did not differ from normal mice in their metabolism of nucleic acids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - RNA
KW - METABOLISM
KW - MICE as laboratory animals
KW - NUCLEIC acids
KW - BIOCHEMISTRY
N1 - Accession Number: 14541942; Chused, T. M. 1 Steinberg, A. D. 2 Talal, N . 3; Affiliation: 1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland. 2: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland. 3: Veterans Administration Hospital, University of California Medical Center, San Francisco, California 94121, U.S.A.; Source Info: Dec72, Vol. 12 Issue 4, p465; Subject Term: DNA; Subject Term: RNA; Subject Term: METABOLISM; Subject Term: MICE as laboratory animals; Subject Term: NUCLEIC acids; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Kulin, H. E.;
AU - Reiter, E. O.;
T1 - Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH
CT - Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1972/12/01/
VL - 35
IS - Dec
SP - 836
EP - 839
AD - Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1 - Accession Number: 10-2566; Language: English; Chemical Name: Ethinyl estradiol--57-63-6; Therapeutic Class: (68:16); AHFS Class: Estrogens ethinyl estradiol; References: 10; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Ethinyl estradiol in doses ranging from 8-50 mcg./day was given for one week in 16 different courses to 10 normal men. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in blood and urine by radioimmunoassay. Utilizing the 95% prediction interval, it was found that 32 mcg. and 42 mcg. suppressed FSH in urine respectively. Significant suppression of LH was not obtained. The results suggest that there is a differential suppressive effect upon FSH and LH by estrogen at threshold doses.
KW - Ethinyl estradiol--effects-;
KW - Estrogens--ethinyl estradiol--effects, low dose, on FSH and LH, in men;
KW - Dosage--ethinyl estradiol--low, effects, on FSH and LH, in men;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MARX, S. J.
AU - WOODARD, C. J.
AU - AURBACH, G. D.
T1 - Calcitonin Receptors of Kidney and Bone.
JO - Science
JF - Science
Y1 - 1972/12//12/ 1/1972
VL - 178
IS - 4064
M3 - Article
SP - 999
EP - 1001
SN - 00368075
AB - Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon calcitonin accounts in part for the high biological potency in vivo of salmon calcitonin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138675; MARX, S. J. 1; WOODARD, C. J. 1; AURBACH, G. D. 1; Affiliations: 1: Section on Mineral Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 1/1972, Vol. 178 Issue 4064, p999; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hill, William G.
AU - Silber, Stanley C.
T1 - Reciprocal aspects of mental health and family service.
JO - Social Casework
JF - Social Casework
Y1 - 1972/12//
VL - 53
IS - 10
M3 - Article
SP - 623
EP - 630
SN - 00377678
AB - A 1971 study of the relationships between 27 mental health centers and family service agencies indicates that benefits accrue when there are formal affiliations between the government and voluntary agencies. 14 notes.
KW - FAMILY services
KW - FAMILY social work
KW - MENTAL health services
KW - GOVERNMENT agencies
KW - ASSOCIATIONS, institutions, etc.
KW - MEDICAL care
KW - MENTAL health
KW - FEDERAL aid
KW - FAMILIES
N1 - Accession Number: 15383529; Hill, William G. 1; Silber, Stanley C. 2; Affiliations: 1 : Professor, School of Social Work, University of Texas, Austin, Texas.; 2 : Chief, Community Support Program, National Institute of Mental Health, Rockville, Maryland.; Source Info: Dec72, Vol. 53 Issue 10, p623; Historical Period: 1971; Subject Term: FAMILY services; Subject Term: FAMILY social work; Subject Term: MENTAL health services; Subject Term: GOVERNMENT agencies; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: MEDICAL care; Subject Term: MENTAL health; Subject Term: FEDERAL aid; Subject Term: FAMILIES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Bonavida, Benjamin
AU - Fuchs, Sara
AU - Sela, Michael
AU - Roddy, Pamela W.
AU - Sober, Herbert A.
T1 - Specific Antibodies to Dinucleotides and Trinucleotides.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1972/12/15/
VL - 31
IS - 3
M3 - Article
SP - 534
EP - 540
PB - Wiley-Blackwell
SN - 00142956
AB - Conjugates of the dinucleoside phosphates ApA, CpA, ApU and CpC (deliberately chosen so that an example of each of the purine-pyrimidine combinations be represented), and of the trinucleoside diphosphates ApApU and ApApC, with bovine serum albumin were used for immunization of rabbits. The specificity of the antibodies obtained was studied by the inhibition of binding of a radioiodinated antigen by different cross-reacting compounds, as well as by the sensitive modified bacteriophage technique. Antibodies of restricted specificity towards di- and trinucleotides were present in the respective homologous antisera. Antibodies to the trinucleoside diphosphates ApApU and ApApC recognize the complete hapten. Usually the nucleoside which is coupled to the protein carrier, and not the terminal one, forms the immunodominant portion of the antigenic determinant. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - NUCLEOTIDES
KW - PYRIMIDINES
KW - IMMUNE serums
KW - HAPTENS
KW - NUCLEIC acids
KW - SERUM albumin
N1 - Accession Number: 12484295; Bonavida, Benjamin 1,2 Fuchs, Sara 1,2 Sela, Michael 1,2 Roddy, Pamela W. 1,2 Sober, Herbert A. 1,2; Affiliation: 1: Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 2: Laboratory of Nutrition and Endocrinology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1972, Vol. 31 Issue 3, p534; Subject Term: IMMUNOGLOBULINS; Subject Term: NUCLEOTIDES; Subject Term: PYRIMIDINES; Subject Term: IMMUNE serums; Subject Term: HAPTENS; Subject Term: NUCLEIC acids; Subject Term: SERUM albumin; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ROSENBERG, MORRIS
T1 - Using Social Data Archives.
JO - Science
JF - Science
Y1 - 1972/12/15/
VL - 178
IS - 4066
M3 - Article
SP - 1193
EP - 1194
SN - 00368075
N1 - Accession Number: 85135735; ROSENBERG, MORRIS 1; Affiliations: 1: Laboratory of Socio-environmental Studies, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 12/15/1972, Vol. 178 Issue 4066, p1193; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bobrow, S. N.;
AU - Jaffe, E.;
AU - Young, R. C.;
T1 - Anuria and acute tubular necrosis associated with gentamicin and cephalothin
CT - Anuria and acute tubular necrosis associated with gentamicin and cephalothin
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/12/18/
VL - 222
IS - Dec 18
SP - 1546
EP - 1547
AD - Building 10, Room 12N226, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-2523; Language: English; Chemical Name: Cephalothin--153-61-7 Gentamicin--1403-66-3; Therapeutic Class: (8:12); AHFS Class: Antibiotics gentamicin (8:12); AHFS Class: Antibiotics cephalothin; References: 11; Publication Type: Brief Reports; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Joan Lentine
N2 - A patient developed acute tubular necrosis following treatment with cephalothin sodium and gentamicin sulfate. The patient was given cephalothin, 2 g. every 6 hours I.V., and gentamicin, 1 mg./kg. every 6 hr. I.V. for a total of 64 g. of cephalothin and 1.9 g. of gentamicin. Postmortem examination confirmed the clinical impression of acute tubular necrosis. No other cause for the renal failure was evident either clinically or at postmortem examination. It could not be determined in this case whether one of the antibiotics independently was responsible for the nephrotoxicity or whether there was a synergistic nephrotoxic effect of the combination.
KW - Cephalothin--interactions-;
KW - Gentamicin--interactions-;
KW - Drug interactions--cephalothin and gentamicin--synergism, possible nephrotoxicity, in patient;
KW - Antibiotics--gentamicin--interactions, cephalothin, synergism, possible nephrotoxicity, in patient;
KW - Antibiotics--cephalothin--interactions, gentamicin, synergism, possible nephrotoxicity, in patient;
KW - Drugs, adverse reactions--gentamicin--interactions, cephalothin, synergism, possible nephrotoxicity, in patient;
KW - Drugs, adverse reactions--cephalothin--interactions, gentamicin, synergism, possible nephrotoxicity, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - WEISMAN, IRWIN D.
AU - BENNETT, LAWRENCE H.
AU - MAXWELL SR., LOUIS R.
AU - WOODS, MARK W.
AU - BURK, DEAN
T1 - Recognition of Cancer in vivo by Nuclear Magnetic Resonance.
JO - Science
JF - Science
Y1 - 1972/12/22/
VL - 178
IS - 4067
M3 - Article
SP - 1288
EP - 1290
SN - 00368075
AB - Pulsed nuclear magnetic resonance has been used to differentiate in vivo between normal mouse tail tissue and a malignant transplanted melanona, S91, located on the tail. The tumnor displayed a nuclear (proton) spin-lattice relaxation time of ~0.7 second contrasted with the simultaneolusly measured normal tail tissue relaxation time of ~0.3 second. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85135778; WEISMAN, IRWIN D. 1; BENNETT, LAWRENCE H. 1; MAXWELL SR., LOUIS R.; WOODS, MARK W. 2; BURK, DEAN 2; Affiliations: 1: Institute for Materials Research, National Bureau of Standards, Gaithersburg, Maryland 20760; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/22/1972, Vol. 178 Issue 4067, p1288; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOIME, H. AVIV I.
AU - LOYD, B.
AU - LEDER, P.
T1 - Translation of Bacteriophage Qβ Messenger RNA in a Murine Krebs 2 Ascites Tumor Cell-Free System.
JO - Science
JF - Science
Y1 - 1972/12/22/
VL - 178
IS - 4067
M3 - Article
SP - 1293
EP - 1295
SN - 00368075
AB - Qβ is a small bacterial virus whose three genes are encoded in a single-stranded molecule of RNA. This RNA serves directly as the Qβ message. Here we describe conditions under which RNA corresponding to the coat cistron of this bacterial virus is translated in a system derived from mammalian cells. Translation of the bacterial virus messenger RNA is less effective than that of mammalian globin messenger RNA, but is somewhat enhanced by mild alkali treatment of the messenger. The synthesized product when subjected to electrophoresis migrates with authentic Qβ coat protein and yields tryptic peptides that correspond to those derived from the Qβ coat protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85135781; BOIME, H. AVIV I. 1; LOYD, B. 1; LEDER, P. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/22/1972, Vol. 178 Issue 4067, p1293; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Goodwin, F. K.;
AU - Post, R. M.;
AU - Dunner, D. L.;
AU - Gordon, E. K.;
T1 - Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique
CT - Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/01/01/
VL - 130
IS - Jan
SP - 73
EP - 79
SN - 0002953X
AD - Laboratory of Clinical Science, Building 10, Room 4S-239, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-3943; Language: English; Chemical Name: Probenecid--57-66-9; Therapeutic Class: (40:40); AHFS Class: Uricosuric agents probenecid; References: 49; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: C. Robert Sturwold
N2 - The accumulation of 5-hydroxyindolacetic acid (I) and homovanillic acid (II) following high doses of probenecid (100 mg./kg./day) was studied in 38 patients with affective illness in order to assess the central amine function for both level and rate of change of biogenic amines. Besides the 38 moderately severe to severely depressed patients, 8 heroin addicts on methadone, and 8 normal controls participated in the study. All subjects except those on methadone were drug free for at least 2 weeks prior to the study. Diets were restricted to exclude foods affecting indoleamine and catecholamine metabolism. The metabolites accumulated were increased by administering precursors which increase amine synthesis and were decreased by administering specific inhibitors of amine synthesis. Compared with controls, depressed patients had low II accumulation (higher in bipolar than in unipolar patients) and addicts on methadone had low I accumulation.
KW - Probenecid--effects-;
KW - Uricosuric agents--probenecid--effects, metabolism, biogenic amines, in CSF, in depressed patients, and in methadone treated addicts;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Murphy, D. L.;
AU - Goodwin, F. K.;
AU - Brodie, K. H.;
AU - Bunney, W. E.;
T1 - L-dopa, dopamine, and hypomania
CT - L-dopa, dopamine, and hypomania
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/01/01/
VL - 130
IS - Jan
SP - 79
EP - 82
SN - 0002953X
AD - Building 10, Room 3S-229, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-3860; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 18; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: C. Robert Sturwold
N2 - A double-blind study was conducted to evaluate whether altered L-dopa (levodopa) metabolism might contribute to the development of hypomania in bipolar patients. With the use of levodopa and a placebo, 4 depressed patients without hypomanic episodes and 4 depressed patients with hypomanic episodes were treated for an average of 145 days. Three to seven 24-hr. urine samples were collected from each patient to measure urinary excretion of dopamine, Homovanillic acid (HVA), and unmetabolized levodopa. Patients who developed hypomania excreted more than twice the amount of dopamine and levodopa during levodopa treatment than the unipolar controls. The data suggest that the increased psychomotor activity observed during hypomania and mania might represent the behavioral effects of increased levels of dopamine formed from levodopa. Changes in dopamine metabolism are implicated in the development of hypomania and mania since the bipolar patients exhibited a differential sensitivity to the development of hypomania and mania during levodopa treatment.
KW - Levodopa--metabolism-;
KW - Antiparkinson agents--levodopa--metabolism, and hypomania, mechanism of action, in psychiatric patients;
KW - Metabolism--levodopa--and hypomania, mechanism of action, in psychiatric patients;
KW - Mechanism of action--levodopa--hypomania, in psychiatric patients;
KW - Toxicity--levodopa--hypomania, mechanism, in psychiatric patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rayner, Jeannette F.
T1 - Communication Between the Public and the Dental Profession.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/01//
VL - 63
IS - 1
M3 - Article
SP - 21
EP - 32
PB - American Public Health Association
SN - 00900036
AB - How do dentists and para-dental workers view the public? And how accurate are these assessments? Based on a sample of such personnel, data were collected to see whether they could accurately judge public responses to selected dental health items. Findings are presented and discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Dental care
KW - Dentist & patient
KW - Dental personnel
KW - Preventive dentistry
KW - Dental students
KW - Public opinion
N1 - Accession Number: 24294383; Rayner, Jeannette F. 1; Affiliations: 1: Public Health Analyst, Office of Social and Behavioral Analysis, Division of Dental Health, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Maryland, 20014; Issue Info: Jan1973, Vol. 63 Issue 1, p21; Thesaurus Term: Public health; Subject Term: Dental care; Subject Term: Dentist & patient; Subject Term: Dental personnel; Subject Term: Preventive dentistry; Subject Term: Dental students; Subject Term: Public opinion; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wolf, Philip A.
AU - Kannel, William B.
AU - McNamara, Patricia M.
AU - Gordon, Tavia
T1 - The Role of Impaired Cardiac Function in Atherothrombotic Brain Infarction: The Framingham Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/01//
VL - 63
IS - 1
M3 - Article
SP - 52
EP - 58
PB - American Public Health Association
SN - 00900036
AB - Atherothrombotic main infarction (ABI) accounted for the majority of the 152 strokes in 5209 people in 16 years of follow-up in the Framingham Heart Disease epidemiology Study. Hypertension (systolic and diastolic) was the major risk factor in ABI, but findings indicate that cardiac abnormalities increase the risk of ABI over and above a blood pressure effect. Control of blood pressure and cardiac impairments likely to lessen occurrence of ABI. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Cerebrovascular disease
KW - Blood pressure
KW - Hypertension
KW - Blood circulation disorders
KW - RISK factors
KW - Diagnosis
KW - Medical care
KW - Framingham (Mass.)
KW - Massachusetts
N1 - Accession Number: 24294389; Wolf, Philip A. 1; Kannel, William B. 2; McNamara, Patricia M. 2; Gordon, Tavia 3; Affiliations: 1: Assistant Professor, Neurology, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; 2: Heart Disease Epidemiology Study, Framingham, Massachusetts; 3: National Heart and Lung Institute, National Institutes of Health, Washington, D.C.; Issue Info: Jan1973, Vol. 63 Issue 1, p52; Thesaurus Term: Diseases; Subject Term: Cerebrovascular disease; Subject Term: Blood pressure; Subject Term: Hypertension; Subject Term: Blood circulation disorders; Subject Term: RISK factors; Subject Term: Diagnosis; Subject Term: Medical care; Subject: Framingham (Mass.); Subject: Massachusetts; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Torrey, E. Fuller
AU - Smith, Debris
AU - Wise, Harold
T1 - The Family Health Worker Revisited: A Five-Year Follow-up.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/01//
VL - 63
IS - 1
M3 - Article
SP - 71
EP - 74
PB - American Public Health Association
SN - 00900036
AB - This paper describes the present position of family health workers who were trained and worked at a neighborhood health center during the past five years. Problems initially anticipated for such workers did not materialize but others have emerged: lack of self-esteem, lack of upward and lateral mobility, inadequate evaluation of the validity of their training and role, and to some extent paternalism. These are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Community health aides
KW - Training
KW - Medical centers
KW - Self-esteem
KW - Self-confidence
KW - Paternalism
KW - Bronx (New York, N.Y.)
KW - New York (N.Y.)
KW - New York (State)
N1 - Accession Number: 24294392; Torrey, E. Fuller 1; Smith, Debris 2; Wise, Harold; Affiliations: 1: Staff Member, New Careers Training Program and Special Assistant to the Director for International Activities, National Institute of Mental Health, Washington, D.C.; 2: Deputy Project Director, Martin Luther King, Jr. Health Center; Issue Info: Jan1973, Vol. 63 Issue 1, p71; Subject Term: Community health aides; Subject Term: Training; Subject Term: Medical centers; Subject Term: Self-esteem; Subject Term: Self-confidence; Subject Term: Paternalism; Subject: Bronx (New York, N.Y.); Subject: New York (N.Y.); Subject: New York (State); NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Rich, R. R.;
AU - Johnson, J. S.;
T1 - Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis
CT - Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis
JO - Arthritis and Rheumatism (USA)
JF - Arthritis and Rheumatism (USA)
Y1 - 1973/01/01/
VL - 16
IS - Jan-Feb
SP - 1
EP - 9
SN - 00043591
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Building 10-11N232, Bethesda, Maryland 20014
N1 - Accession Number: 10-2735; Language: English; References: 18; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2 - Liver function was studied in patients with juvenile rheumatoid arthritis (JRA) who were treated with salicylates insoes sufficient to produce high serum levels. Salicylates were administered to 6 patients with juvenile rheumatoid arthritis in doses sufficient to produce a serum level in excess of 25 mg./100 ml. All 6 patients developed elevations of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. In addition, 4 patients had other evidence of hepatic dysfunction. Liver biopsies performed in 2 patients revealed a mononuclear cell infiltration. These dose related abnormalities were reversible. Routine liver function studies and serum salicylate levels should be made in patients receiving chronic high-dose salicylate therapy.
KW - Salicylates--effects--liver function, rheumatoid arthritis, therapy, in children;
KW - Toxicity--salicylates--effects, liver function, rheumatoid arthritis, therapy, in children;
KW - Arthritis--salicylates--toxicity, hepatic, in children;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2735&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Curtis, J. E.;
AU - Sharp, J. T.;
AU - Lidsky, M. D.;
AU - Hersh, E. M.;
T1 - Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment
CT - Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment
JO - Arthritis and Rheumatism (USA)
JF - Arthritis and Rheumatism (USA)
Y1 - 1973/01/01/
VL - 16
IS - Jan-Feb
SP - 34
EP - 42
SN - 00043591
AD - (Reprints: Department of Medicine, Princess Margaret Hospital, 500 Sherbourne Street, Toronto 5, Ontario, Canada
AD - Collaborative Research Program, Transplantation Immunology Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1 - Accession Number: 10-3078; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 31; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2 - The immune responses of patients with rheumatoid arthritis are assessed and correlated with the clinical features of the disease. Eleven patients had been randomly assigned to receive cyclophosphamide, 50 to 75 mg./day, and 10 to receive a placebo. Immunologic responsiveness was assessed by delayed hypersensitivity skin testing, immunoglobulin levels, in vitro lymphocyte blastogenesis and the primary immune response. All patients had elevated levels of IgG, normal or low IgA, and IgM. Delayed hypersensitivity and in vitro lymphocyte blastogenic responses after immunization with the primary antigens, keyhole limpet hemocyanin and the amino acid copolymer (GLAT), were normal. Keyhole limpet hemocyanin and GLAT hemagglutinin titers were lower than normal due to decreased IgG and IgM formation. Treatment for 8 weeks with cyclophosphamide, 50 to 75 mg./day, did not alter the clinical status of the patients and had no detectable effect on immune reactivity.
KW - Cyclophosphamide--arthritis-;
KW - Antineoplastic agents--cyclophosphamide--arthritis, rheumatoid, effects, immune responses, in patients;
KW - Arthritis--cyclophosphamide--rheumatoid, effects, immune responses, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3078&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Tauber, Stephen J
AU - Werner, Franklin L
T1 - Information activities and services of the national cancer institue
JO - Dhew Publ. No. (nih)74-543. Tr-73-1575-10. Contract No1-cn-35011. 1973 November 30. Informatics Inc., Information Sytems Company, 6000 Executive Boulevard, Rockville, Maryland. Xi + 106 P. 0 Ref
JF - Dhew Publ. No. (nih)74-543. Tr-73-1575-10. Contract No1-cn-35011. 1973 November 30. Informatics Inc., Information Sytems Company, 6000 Executive Boulevard, Rockville, Maryland. Xi + 106 P. 0 Ref
Y1 - 1973///
M3 - Book Chapter
AB - Describes more than 100 sources of information and publications within the national cancer institute. Listings include name, address, and telephone of the person to contact and also information regarding ordering and accessibility. Listings are classed under twelve general headings: primary publications, secondary publications, general technical publications, administrative publications, computerized data banks, libraries and manual data files, special collections and activities, task forces, seminars and symposia, workshops, conferences, and general information activities. An index provides access by subjects or by organizational units associated with the information activities.
N1 - Accession Number: ISTA0902399; Tauber, Stephen J 1; Werner, Franklin L; Affiliations: 1 : National Cancer Institute; Source Info: 1973; Note: Update Code: 0900; Document Type: Book Chapter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0902399&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Levy, R. I.;
AU - Rifkind, B. M.;
T1 - Lipid lowering drugs and hyperlipidemia
CT - Lipid lowering drugs and hyperlipidemia
JO - Drugs (New Zealand)
JF - Drugs (New Zealand)
Y1 - 1973/01/01/
VL - 6
IS - Jan
SP - 12
EP - 45
SN - 00126667
AD - Lipid Metabolism Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 11-1726; Language: English; References: 66; Journal Coden: DRUGAY; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Kenneth J. Bender
N2 - A review of hyperlipidemia and its treatment, with emphasis on the need to consider all lipoproteins rather than just plasma cholesterol, is presented. Five types of hyperlipoproteinemia are defined along with their mechanisms and management. Diet is discussed as well as drugs and correlations of the lipolipidemic agents and coronary heart disease are drawn.
KW - Nutrition--diet--hyperlipidemia, therapy, review;
KW - Antilipemic agents--hyperlipidemia--therapy, review;
KW - Hyperlipidemia--antilipemic agents--and diet, therapy, review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1726&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rhaese, Hans-Jürgen
AU - Boetker, Naomi Kay
T1 - The Molecular Basis of Mutagenesis by Methyl and Ethyl Methanesulfonates.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1973/01//
VL - 32
IS - 1
M3 - Article
SP - 166
EP - 172
PB - Wiley-Blackwell
SN - 00142956
AB - The molecular basis of the biological effect of alkylation, mutation induction and inactivation, was studied using transforming DNA. Comparative studies of mutation induction after methylation (by methyl methanesulfonate) and ethylation (by ethyl methanesulfonate) showed that methylation was five to ten times more effective than ethylation. This observation confirms chemical studies of the reactivities of the individual bases of DNA but conflicts sharply with observations that methyl methanesulfonate is much less mutagenic than ethyl methanesulfonate in bacteriophage and some higher organisms. In each case the number of mutational events caused in transforming DNA followed single-hit kinetics. After termination of alkylation, the rates of decrease of mutants caused by methylation was twice that caused by ethylation, which fits chemical estimates of depurination rates. Reverse mutation studies with different mutagens and base analogs indicated that methyl methanesulfonate predominantly methylates guanine whereas ethyl methanesulfonate alkylates guanine and also adenine; in both cases the major product is an N7-alkyl purine. Accordingly the cause of base-pairing mistakes is unlikely to be related to stearic effects of the alkyl group but rather due to ionization of the alkylated guanine. In addition, inactivation of transforming activity was observed to be linear with treatment time of DNA with methyl or ethyl methanesulfonate in a semilogarithmic plot. Since the observed inactivation rates cannot be solely explained as inactivating mutagenic events produced by base alkylation, it is likely that phosphate alkylation is inactivating. Lethal and mutagenic DNA alterations are shown to be dissociated processes by the following observations. (a) After termination of alkylation, the number of mutants caused by alkylation of the purine bases decreased linearly with time indicating that depurination is inactivating. (b) Under identical conditions, the number of total transformants decreased three times faster than the number of mutants, indicating that in addition to depurination triester breaks must be responsible for inactivation. Therefore, base alkylations are mutagenic and depurination and triester breaks are lethal DNA alterations. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - ALKYLATION
KW - METHANESULFONATES
KW - BIOMOLECULES
KW - MUTAGENESIS
KW - DNA damage
N1 - Accession Number: 13478548; Rhaese, Hans-Jürgen 1 Boetker, Naomi Kay 1; Affiliation: 1: Arbeitsgruppe Molekulare Genetik im Fachbereich Biologie, J. W. Goethe-Universität, Frankfurt a. M., and Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: 1973, Vol. 32 Issue 1, p166; Subject Term: DNA; Subject Term: ALKYLATION; Subject Term: METHANESULFONATES; Subject Term: BIOMOLECULES; Subject Term: MUTAGENESIS; Subject Term: DNA damage; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Cosmides, G. J.;
T1 - Human variability and the safer, more effective use of drugs
CT - Human variability and the safer, more effective use of drugs
JO - Hosp. Formul. Manage.
JF - Hosp. Formul. Manage.
Y1 - 1973/01/01/
VL - 8
IS - Jan
SP - 7
EP - 5
AD - Pharmacology/Toxicology Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4335; Language: English; References: 10; Journal Coden: HOFMAY; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Paul R. Webster
N2 - A discussion of the variability of humans anatomically, physiologically and biochemically and the effect on an individual's response to drugs is presented. The variation in any response to drugs caused by genetics, environment, or gene-environment interaction is discussed in detail. It is suggested that rational therapy can only be attained through a diligent awareness of the individuality of every human being. The planning of experimental investigations, the interpretation of results, and their application to the practical problems of life must always be viewed in this light.
KW - Rational therapy--effects--pharmacogenetics, and environment, on individuals;
KW - Pharmacogenetics--effects--on drug response, in individuals;
KW - Drugs--effects--variability, due to genetics and environment;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4335&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Osborne, Harold F
T1 - Criticism and creativity
JO - In Society For Technical Communication, Inc. Proceedings Of The 20th International Technical Communications Conference, Houston, Texas, May 9-12, 1973. P. 107-109. 0 Ref. See Isa 74-021/y
JF - In Society For Technical Communication, Inc. Proceedings Of The 20th International Technical Communications Conference, Houston, Texas, May 9-12, 1973. P. 107-109. 0 Ref. See Isa 74-021/y
Y1 - 1973///
M3 - Book
AB - The editorial function is similar to literary criticism in that it contributes to improvement in the quality of what is written and read. While the editor's function is little know outside the publishing professions, and is infrequently acknowledged as contributory, particularly by writersm it is positive and constructive, removal of traces of the writer's creative difficultyl adds style to the writer's work. Removal of excess wordage adds effectiveness and vigor. Qualities that characterize good writing can be added by a editor if they are not provided by the author. These processes are creative, in that they produce something that was not present previously. The creative satisfactions for editors are akin to those of writers.
N1 - Accession Number: ISTA0900204; Osborne, Harold F 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1973; Note: Update Code: 0900; Document Type: Book
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0900204&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Schneider, John H
T1 - Development of the autoclass system for automated creation and maintenance of hierarchical classifications
JO - In Waldron, Helen J., Ed.; Long F. Raymond, Ed. Proceedings Of The American Society For Information Science. Volume 10. 36th Annual Meeting, Los Angeles, California, October 21-25, 1973. 1973. Greenwood Press, Westport, Connecticut. P. 205-206. 5 Ref. See
JF - In Waldron, Helen J., Ed.; Long F. Raymond, Ed. Proceedings Of The American Society For Information Science. Volume 10. 36th Annual Meeting, Los Angeles, California, October 21-25, 1973. 1973. Greenwood Press, Westport, Connecticut. P. 205-206. 5 Ref. See
Y1 - 1973///
M3 - Book
AB - The development of an automated system, autoclass, is described. It consists of three major processing programs which use simple punched card input to create complex print-ready records in indented hierarchical format. All programs are written in pl/i and are executed on a ibm 360 or 370 computer. Special features (stated) facilitate updating and permit wide latitude in format of both category numbers and text.
N1 - Accession Number: ISTA0901935; Schneider, John H 1; Affiliations: 1 : National Cancer Institute, Bethesda, Maryland.; Source Info: 1973; Note: Update Code: 0900; Document Type: Book
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0901935&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Cargille, C. M.;
AU - Vaitukaitis, J. L.;
AU - Bermudez, J. A.;
AU - Ross, G. T.;
T1 - Differential effect of ethinyl estradiol upon plasma FSH and LH relating to time of administration in the menstrual cycle
CT - Differential effect of ethinyl estradiol upon plasma FSH and LH relating to time of administration in the menstrual cycle
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1973/01/01/
VL - 36
IS - Jan
SP - 87
EP - 94
AD - Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
N1 - Accession Number: 11-3552; Language: English; Chemical Name: Ethinyl estradiol--57-63-6; References: 17; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The hypothesis that orally administered exogenous estrogen might exert differing effects upon circulating levels of plasma follicle stimulating and luteinizing hormones depending upon the time of administration during the menstrual cycle was investigated in 7 volunteers. Ethinyl estradiol, (I) 100 mcg./day, was administered from days 9-18, counting the day of onset of menses as day 0. Plasma FSH and LH concentrations were compared to those from 7 untreated controls. FSH showed a transitory elevation, marked decline, and prominent rebound following cessation of I. LH showed a sustained elevation during I therapy, with a maximum elevation near midcycle. Maximal levels of FSH and LH, which occurred concomitantly in controls, were dissociated in 6 of 7 women receiving I. These results were contrasted to those observed when the same days 0-7 when suppression of both FSH and LH was noted without the occurrence of peaks during therapy. These results provide evidence that the effect of orally administered exogenous estrogen upon plasma gonadotropins varies with the time of administration in the menstrual cycle.
KW - Ethinyl estradiol--effects-;
KW - Dosage schedules--ethinyl estradiol--effects, endogenous hormone blood levels, time dependent, in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ungaro, P. C.;
AU - Drake, W. P.;
AU - Mardiney, M. R., Jr.;
T1 - Repetitive administration of BCG in prevention and treatment of spontaneous leukemia of AKR mice
CT - Repetitive administration of BCG in prevention and treatment of spontaneous leukemia of AKR mice
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/01/01/
VL - 50
IS - Jan
SP - 125
EP - 128
SN - 00278874
AD - Section of Immunology and Cell Biology, National Cancer Institute Baltimore Cancer Research Centre, Baltimore, Maryland 21211
N1 - Accession Number: 11-0233; Language: English; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; References: 15; Section Heading: Drug Evaluations
N2 - Female AKR mice were randomly grouped at 8 weeks of age and treated every 2nd week thereafter until 42 weeks of age with I.P. BCG or saline. BCG treatment increased the survival time but did not prevent the eventual onset of leukemia. The responses were dose related.
KW - BCG vaccines--leukemias-;
KW - Immunosuppressive agents--BCG vaccines--leukemias, therapy and prevention, in mice;
KW - Dosage--BCG vaccines--leukemias, therapy and prevention, in mice;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0233&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - CHAP
ID - 2004-15428-005
AN - 2004-15428-005
AU - Arenberg, David
ED - Eisdorfer, Carl
ED - Lawton, M. Powell
ED - Eisdorfer, Carl, (Ed)
ED - Lawton, M. Powell, (Ed)
T1 - Cognition and aging: Verbal learning, memory, problem solving, and aging.
T2 - The psychology of adult development and aging.
Y1 - 1973///
SP - 74
EP - 97
CY - Washington, DC, US
PB - American Psychological Association
N1 - Accession Number: 2004-15428-005. Partial author list: First Author & Affiliation: Arenberg, David; National Institutes of Health, Gerontology Research Center, Section on Human Learning and Problem Solving, Baltimore, MD, US. Release Date: 20040726. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Major Descriptor: Aging; Cognition; Memory; Problem Solving; Verbal Learning. Minor Descriptor: Gerontology. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24.
AB - Prior to 1960, the literature on cognition and aging could have been reviewed exhaustively in two chapters. Today, even a review of selected literature could reach book-length proportions. In this chapter, a comprehensive review will not be attempted. Instead, recent representative studies in verbal learning, memory, and problem solving will be reviewed to outline the developments in theory and research since the late fifties when two important syntheses of the available knowledge about cognition and aging were published. In this chapter, cognition is viewed as effectiveness in dealing with information. The chapter deals predominantly with the processes of registering, storing, and retrieving information and with manipulating information to solve a problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognition
KW - aging
KW - gerontology
KW - verbal learning
KW - problem solving
KW - memory
KW - 1973
KW - Aging
KW - Cognition
KW - Memory
KW - Problem Solving
KW - Verbal Learning
KW - Gerontology
KW - 1973
DO - 10.1037/10044-005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15428-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2004-15428-016
AN - 2004-15428-016
AU - Kramer, Morton
AU - Taube, Carl A.
AU - Redick, Richard W.
ED - Eisdorfer, Carl
ED - Lawton, M. Powell
ED - Eisdorfer, Carl, (Ed)
ED - Lawton, M. Powell, (Ed)
T1 - Patterns of use of psychiatric facilities by the aged: Past, present, and future.
T2 - The psychology of adult development and aging.
Y1 - 1973///
SP - 428
EP - 528
CY - Washington, DC, US
PB - American Psychological Association
N1 - Accession Number: 2004-15428-016. Partial author list: First Author & Affiliation: Kramer, Morton; National Institute of Mental Health, Biometry Branch, US. Release Date: 20040726. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Language: English. Major Descriptor: Aging; Health Care Utilization; Health Service Needs; Prediction; Trends. Minor Descriptor: Community Services; Geriatric Patients; Mental Disorders; Mental Health; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 101.
AB - Presented in this chapter is a discussion of trends in patterns of use of various types of psychiatric facilities by the aged; predictions of future needs of mental health services for the aged; estimates of numbers of psychiatrists, psychologists, psychiatric nurses, and psychiatric social workers needed to care for persons with mental disorders relative to estimates of the available supply of such professionals in 1970, 1975, and 1980; and other areas of concern for planning of mental health, general health, and related services for the aged, such as community care of the aged with disabling conditions, hospitalization of the aged for all diseases and disabling conditions, and living arrangements of the aged. It is hoped that a consideration of these topics and of the questions they may suggest will help to define more clearly the role of psychology and psychologists not only in the actual delivery of medical, psychiatric, psychological, and related human services required to maintain and to improve the mental, physical, and social well-being of the aged, but also in the many activities on which the delivery of such services depends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trends
KW - psychiatric facility use
KW - aged
KW - mental health services
KW - future needs
KW - prediction
KW - 1973
KW - Aging
KW - Health Care Utilization
KW - Health Service Needs
KW - Prediction
KW - Trends
KW - Community Services
KW - Geriatric Patients
KW - Mental Disorders
KW - Mental Health
KW - Mental Health Services
KW - 1973
DO - 10.1037/10044-016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15428-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41471-014
AN - 2013-41471-014
AU - Bandler, Bernard
T1 - Interprofessional collaboration in training in mental health.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/01//
VL - 43
IS - 1
SP - 97
EP - 107
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Bandler, Bernard, 157 Brattle Street, Cambridge, MA, US, 02138
N1 - Accession Number: 2013-41471-014. PMID: 4705922 Partial author list: First Author & Affiliation: Bandler, Bernard; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Centers; Community Mental Health Training; Mental Health Personnel; Minority Groups; Professional Networking. Minor Descriptor: Cooperation. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 11. Issue Publication Date: Jan, 1973.
AB - The mental health professions have much in common in knowledge and skills. This commonality is increased by the experiences of teams in community mental health centers, the advent of new careerists, and work with minority cultures. The suggestion is advanced for experiments in interprofessional collaboration in training in both the curriculum and practicum. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - interprofessional collaboration
KW - mental health training
KW - community mental health centers
KW - minority cultures
KW - mental health professions
KW - 1973
KW - Community Mental Health Centers
KW - Community Mental Health Training
KW - Mental Health Personnel
KW - Minority Groups
KW - Professional Networking
KW - Cooperation
KW - 1973
DO - 10.1111/j.1939-0025.1973.tb00789.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41471-018
AN - 2013-41471-018
AU - Shore, Milton F.
AU - Massimo, Joseph L.
T1 - After ten years: A follow-up study of comprehensive vocationally oriented psychotherapy.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/01//
VL - 43
IS - 1
SP - 128
EP - 132
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-41471-018. PMID: 4705906 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Psychotherapy; Remedial Education; Vocational Rehabilitation. Minor Descriptor: Community Services; Identity Formation; Personnel Placement. Classification: Criminal Behavior & Juvenile Delinquency (3236); Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jan, 1973.
AB - The third in a series of follow-up studies of adolescent delinquent boys successfully treated in a community-based program that combined job placement, remedial education, and psychotherapy shows significantly better overall adjustment in the treated group when compared with untreated controls. The lack of any major change in direction over a decade seems to confirm the significance for later development of identity formation during adolescence, and the need for priority to be given to innovative means of reaching adolescents during the crises that arise in that developmental period. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vocationally oriented psychotherapy
KW - adolescent delinquent boys
KW - community based programs
KW - job placement
KW - remedial education
KW - identity formation
KW - 1973
KW - Juvenile Delinquency
KW - Male Delinquency
KW - Psychotherapy
KW - Remedial Education
KW - Vocational Rehabilitation
KW - Community Services
KW - Identity Formation
KW - Personnel Placement
KW - 1973
DO - 10.1111/j.1939-0025.1973.tb00793.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41471-026
AN - 2013-41471-026
AU - Huxley, Matthew
T1 - Review of Your money or your life: Rx for the medical marketplace.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/01//
VL - 43
IS - 1
SP - 174
EP - 175
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41471-026. Partial author list: First Author & Affiliation: Huxley, Matthew; Standards Development Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Health Care Services; Health Service Needs; Health Care Policy. Minor Descriptor: Neighborhoods; Prevention; Social Programs. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Kunnes, Riehard. Your money or your life: Rx for the medical marketplace=New York: Dodd, Mead. 205 pp. $5.95; 1972. Page Count: 2. Issue Publication Date: Jan, 1973.
AB - Reviews the book, Your Money Or Your Life: Rx for the Medical Marketplace by Riehard Kunnes (1972). Briefly, in this book, the problem under discussion is the non-accountability, non-responsibility, and non-responsiveness of our health care non-system to the needs of all of the non-filthy rich of this richest country in the world. His solution, of course, lies in the establishment of consumer-health worker councils controlling the planning, budgeting, medical policies, personnel, and salaries of all health services organized into a network of neighborhood service units focusing on an aggressive outreach and prevention program. In the reviewer's opinion, the book desperately needs editing and proofing, which the publisher failed to require or supply; it is repetitive, it rambles it lacks coherence and continuity. And the final disaster is that it is dull the cardinal sin of any rallying manifesto which is what this tract clearly set out to be. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical marketplace
KW - health services
KW - medical policies
KW - prevention programs
KW - health service needs
KW - neighborhood services
KW - 1973
KW - Health Care Services
KW - Health Service Needs
KW - Health Care Policy
KW - Neighborhoods
KW - Prevention
KW - Social Programs
KW - 1973
U2 - Kunnes, Riehard. (1972); Your money or your life: Rx for the medical marketplace; New York: Dodd, Mead. 205 pp. $5.95
DO - 10.1037/h0097673
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41471-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Arseneau, J. C.;
AU - Bagley, C. M.;
AU - Anderson, T.;
AU - Canellos, G. P.;
T1 - Hyperkalemia, a sequel to chemotherapy of Burkitt's lymphoma
CT - Hyperkalemia, a sequel to chemotherapy of Burkitt's lymphoma
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/01/06/
VL - 1
IS - Jan 6
SP - 10
EP - 14
SN - 00237507
AD - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-2713; Language: English; Chemical Name: Allopurinol--315-30-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents allopurinol; References: 16; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - Hyperkalemia developing within 48 hours of chemotherapy was found in retrospective analysis in 5 of 22 evaluable cases of Burkitt's lymphoma in patients. Most patients had been receiving allopurinol. Clinical and animal studies suggest that hyperkalemia is related to sudden lysis of large volumes of tumor. Patients at serious risk were found to be those with large tumor masses and/or impairment of renal function. Close observation, parenteral hydration, and diuretic therapy, control of hyperuricemia, reduction of the initial dose of chemotherapy, and, if necessary, dialysis are suggested during the initial therapy of these high risk Burkitt's lymphoma patients.
KW - Allopurinol--Burkitt's lymphoma-;
KW - Solutions--irrigating--adverse reactions, hyperkalemia, in Burkitt's lymphoma patients;
KW - Antineoplastic agents--allopurinol--Burkitt's lymphoma, therapy, in patients, hyperkalemia due to lysis with irrigating solutions;
KW - Drugs, adverse reactions--solutions--irrigating, hyperkalemia, in Burkitt's lymphoma patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carbone, P. P.;
T1 - Management with combination therapy
CT - Management with combination therapy
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/01/08/
VL - 223
IS - Jan 8
SP - 165
EP - 166
AD - Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 10-2784; Language: English; Publication Type: Current Concepts in Cancer Number 40; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2 - Studies in which combination therapy has proven successful in treating Hodgkin's disease are discussed.
KW - Combined therapy--antineoplastic agents--Hodgkin's disease, in patients, discussion;
KW - Antineoplastic agents--combined therapy--Hodgkin's disease, in patients, discussion;
KW - Hodgkin's disease--antineoplastic agents--combined therapy, in patients, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Freedman, Murray H.
AU - Lyerla Jr., James R.
AU - Chaiken, Irwin M.
AU - Cohen, Jack S.
T1 - Carbon-13 Nuclear-Magnetic-Resonance Studies on Selected Amino Acids, Peptides, and Proteins.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1973/01/15/
VL - 32
IS - 2
M3 - Article
SP - 215
EP - 226
PB - Wiley-Blackwell
SN - 00142956
AB - Natural abundance high-resolution carbon-13 Fourier transform nuclear magnetic resonance (13C NMR) studies at 25 MHz have been carried out on selected amino acids, linear peptides and proteins. The pH dependence of the 13C resonances has been studied in detail in several cases. For L-histidine, the 13C chemical shifts of all six carbon atoms are sensitive to the ionization state of the titrating carboxyl, imidazole and amino groups. The data for each carbon resonance have been computer-fitted to a sum of three theoretical curves based on a simple proton-association equilibrium for each transition. The extent of chemical shift change upon ionization of a nearby group has been interpreted in terms of two competing effects, inductive (through-bond) and electric field (through-space) effects. The 13C NMR spectra of the amino-terminal 1–13, 1–15, and 1–20 peptides of bovine pancreatic ribonuclease A have been analyzed. Detailed resonance assignments have been made based on comparisons with the results for the free amino acids, shift effects for amino acids in small peptides, internal peptide bond effects and differences in amino acid composition. There is considerable correspondence between the observed 13C chemical shifts of these peptides and those predicted from the shifts of the component amino acids. Proteins of varying molecular weight have been studied to evaluate the potential of 13C NMR investigations of structure and conformation. A comparison has been made between the 13C NMR spectra of hen egg-white lysozyme in its native and reduced states. The spectrum of the fully reduced species appears to be well represented by the sum of the spectra of the individual amino acids, both in chemical shift and line width, whereas that for the native form exhibits consistently broader resonances. Similar results were obtained for ribonuclease A. At the current level of resolution, it is impossible to discern whether this line broadening derives from shorter relaxation time effects due to restricted motion, chemical shift non-equivalence between the same chemical groups, or both. However, it does appear that there are separately resolved peaks corresponding to Cβ-carbons for different threonyl residues, as well as for the C-4 ring carbons of the several tyrosyl residues in native hen egg-white lysozyme. Spectra of carbonic anhydrases (Mr ≈ 30000), which lack disulphide bonds, showed somewhat poorer resolution than the smaller proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance
KW - MAGNETIC resonance
KW - AMINO acids
KW - PEPTIDES
KW - PROTEINS
KW - RESEARCH
N1 - Accession Number: 12485129; Freedman, Murray H. 1 Lyerla Jr., James R. 1 Chaiken, Irwin M. 1 Cohen, Jack S. 1; Affiliation: 1: Faculty of Pharmacy, University of Toronto, Laboratory of Chemical Biology, National Institute of Arthritis and Metabolic Diseases, and Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland; Source Info: 1973, Vol. 32 Issue 2, p215; Subject Term: NUCLEAR magnetic resonance; Subject Term: MAGNETIC resonance; Subject Term: AMINO acids; Subject Term: PEPTIDES; Subject Term: PROTEINS; Subject Term: RESEARCH; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KREUZ, DAVID S.
AU - AXETLROD, JULIus
T1 - Delta-9-Tetrahydrocannabinol: Localization in Body Fat.
JO - Science
JF - Science
Y1 - 1973/01/26/
VL - 179
IS - 4071
M3 - Article
SP - 391
EP - 393
SN - 00368075
AB - [141C]Δ9-Tetrahydrocannabinol (Δ9THC) was injected subcutaneously in rats every day for I to 26 days. Concentrations of Δ9THC and its mnetabolites, 11 -hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ9THC in fat was ten times greater than in any other tissiue examnined, and persisted in this tissue for 2 weeks. With repeated injection, A9THC and its metabolites accumulated in fat and brain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85135893; KREUZ, DAVID S. 1; AXETLROD, JULIus 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health. Bethe.sda, Maryland 20014; Issue Info: 1/26/1973, Vol. 179 Issue 4071, p391; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kohn, Melvin L.
AU - Schooler, Carmi
T1 - OCCUPATIONAL EXPERIENCE AND PSYCHOLOGICAL FUNCTIONING: AN ASSESSMENT OF RECIPROCAL EFFECTS.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1973/02//
VL - 38
IS - 1
M3 - Article
SP - 97
EP - 118
SN - 00031224
AB - The central issue of this paper is whether men's adult occupational experiences affect or only reflect their psychological functioning. Our analysis isolates a small set of occupational conditions, twelve in all, which defines the structural imperatives of the job. These occupational conditions are found to be substantially related to men's psychological functioning, off as well as on the job. We argue that the relationships between occupational conditions and psychological functioning result from a continuing interplay between job and man, in which the effects of job on man are far from trivial. This argument is borne out by an assessment of the reciprocal effects of the substantive complexity of the work (a critically important occupational condition, for which we have the requisite longitudinal data) and several facets of psychological functioning. Substantive complexity has a decidedly greater impact on psychological functioning than the reverse. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAN-woman relationships
KW - PROFESSIONAL relationships
KW - OCCUPATIONAL prestige
KW - PSYCHOLOGY
KW - OCCUPATIONS
KW - PROFESSIONAL practice
KW - BEHAVIOR
N1 - Accession Number: 14741183; Kohn, Melvin L. 1; Schooler, Carmi 1; Affiliations: 1 : National Institute of Mental Health.; Source Info: Feb73, Vol. 38 Issue 1, p97; Historical Period: 1964 to 1971; Subject Term: MAN-woman relationships; Subject Term: PROFESSIONAL relationships; Subject Term: OCCUPATIONAL prestige; Subject Term: PSYCHOLOGY; Subject Term: OCCUPATIONS; Subject Term: PROFESSIONAL practice; Subject Term: BEHAVIOR; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
TY - GEN
AU - Blaschke, T. F.;
AU - Elin, R. J.;
AU - Berk, P. D.;
AU - Song, C. S.;
AU - Wolff, S. M.;
T1 - Effect of induced fever on sulfobromophthalein kinetics in man
CT - Effect of induced fever on sulfobromophthalein kinetics in man
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/02/01/
VL - 78
IS - Feb
SP - 221
EP - 226
SN - 00034819
AD - Metabolism Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4N117, Bethesda, Maryland 20014
N1 - Accession Number: 10-2891; Language: English; Chemical Name: Sulfobromophthalein--297-83-6; Therapeutic Class: (36:00); AHFS Class: Diagnostic agents sulfobromophthalein; References: 23; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg./kg. of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values of BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.
KW - Sulfobromophthalein--blood levels-;
KW - Diagnostic agents--sulfobromophthalein--blood levels, changed by pyrogen induced fever, in humans;
KW - Pharmacokinetics--sulfobromophthalein--blood levels, changed by pyrogen induced fever, in humans;
KW - Tests--laboratory--sulfobromophthalein, changes, by pyrogen induced fever, in humans;
KW - Metabolism--sulfobromophthalein--blood levels, changed, by pyrogen induced fever, in humans;
KW - Blood levels--sulfobromophthalein--changes, by pyrogen induced fever, in humans;
KW - Fever--effects--sulfobromophthalein, changes, blood levels, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
AU - Jasinski, D. R.;
AU - Haertzen, C. A.;
AU - Kay, D. C.;
AU - Jones, B. E.;
AU - \ET/;
T1 - Methadone\M/a reevaluation
CT - Methadone\M/a reevaluation
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/02/01/
VL - 28
IS - Feb
SP - 286
EP - 295
AD - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky
N1 - Accession Number: 10-5085; Language: English; Chemical Name: Methadone--76-99-3; References: 36; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Two double-blind studies using single doses of methadone hydrochloride and chronic methadone administration determined and compared the physiological changes in illicit narcotic users. Single doses of 10 mg. and 20 mg. produced subjective changes similiar to equipotent doses of morphine sulfate. Long-term daily usage of 100 mg. of oral methadone showed physical dependence comparable to injectable morphine, but a slower onset of abstinence syndrome. Sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution and edema emerged during the studies. The ability of methadone maintenance to block euphoria and to prevent the drug-seeking behavior was challenged by 4 mg. of I.V. hydromorphone hydrochloride (Dilaudid).
KW - Methadone--dosage-;
KW - Dosage--methadone--effects, in drug abusers;
KW - Dependence--methadone--oral, compared to IV morphine dependence;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bagley, C. M.;
AU - Bostick, F. W.;
AU - DeVita, V. T.;
T1 - Clinical pharmacology of cyclophosphamide
CT - Clinical pharmacology of cyclophosphamide
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1973/02/01/
VL - 33
IS - Feb
SP - 226
EP - 233
SN - 00085472
AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-3570; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 30; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Pharmacology; Abstract Author: Thomas E. O'Brien
N2 - The human pharmacology of labeled cyclophosphamide, was investigated in 26 patients. Methods for determining the half-life, excretion and metabolism are outlined. The use of this drug in non-neoplastic diseases is discussed.
KW - Cyclophosphamide--metabolism-;
KW - Antineoplastic agents--cyclophosphamide--metabolism, half-life and excretion, in patients;
KW - Half-life--cyclophosphamide--and metabolism, in patients;
KW - Metabolism--cyclophosphamide--half-life, and excretion, in patients;
KW - Excretion--cyclophosphamide--and metabolism, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kennell, William B.
AU - Shurtleff, Dewey
T1 - Cigarettes and the development of intermittent claudication.
JO - Geriatrics
JF - Geriatrics
Y1 - 1973/02//
VL - 28
IS - 2
M3 - Article
SP - 61
EP - 68
SN - 0016867X
N1 - Accession Number: 17525029; Kennell, William B. 1; Shurtleff, Dewey 1; Source Information: Feb1973, Vol. 28 Issue 2, p61; Number of Pages: 8p; Illustrations: 7 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 3487
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Thompson, W. O.;
AU - Christian, S. T.;
T1 - Calculating rate constants in forward drug transfer reactions (in vitro model cells)
CT - Calculating rate constants in forward drug transfer reactions (in vitro model cells)
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/02/01/
VL - 62
IS - Feb
SP - 328
EP - 330
SN - 00223549
AD - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky 40507
N1 - Accession Number: 12-0088; Language: English; Journal Coden: JPMSAE; Section Heading: Pharmaceutics
KW - Drugs--transfer--rate constants, calculation, in vitro model cells;
KW - Rate constants--drugs--transfer, in vitro model cells;
KW - Models--drugs--transfer, calculation of rate constants;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - EVARTS, EDWARD V.
T1 - Motor Cortex Reflexes Associated with Learned Movement.
JO - Science
JF - Science
Y1 - 1973/02/02/
VL - 179
IS - 4072
M3 - Article
SP - 501
EP - 503
SN - 00368075
AB - In primates, sensory input can generate reflex motor cortex output in association with learned movement when the sensory input has a strong and direct connection to the motor cortex-for example, when a stimulus calling for repositioning of the hand consists of a perturbation of hand position. This finding supports the proposal that neurons of primate motor cortex may function in a transcortical servo-loop. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85135935; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health. National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1973, Vol. 179 Issue 4072, p501; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SIGGINS, G. R.
AU - BATTENBERG, E. F.
AU - HOFFER, B. J.
AU - BLOOM, F. E.
AU - STEINER, A. L.
T1 - Noradrenergic Stimulation of Cyclic Adenosine Monophosphate in Rat Purkinje Neurons: An Immunocytochemical Study.
JO - Science
JF - Science
Y1 - 1973/02/09/
VL - 179
IS - 4073
M3 - Article
SP - 585
EP - 588
SN - 00368075
AB - A specific immunofluorescent histochemical method for cyclic adenosine monophosphate was used to study rat cerebellum. After topical treatment with norepinephrine or stimulation of norepinephrine-containing afferents from locus coeruleus, there was a striking increase in the number of Purkinje cells with strong cyclic adenosine monophosphate reactivity. Other putative inhibitory transmitters had no significant effect on staining of Purkinje cells. The results provide the first histochemical support for the hypothesis that cyclic adenosine monophosphate can be generated postsynaptically in central neurons in response to noradrenergic stimuli [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85135977; SIGGINS, G. R. 1; BATTENBERG, E. F. 1; HOFFER, B. J. 1; BLOOM, F. E. 1; STEINER, A. L. 2; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C.; 2: Department of Medicine, Albany Medical College, Albany, New York; Issue Info: 2/ 9/1973, Vol. 179 Issue 4073, p585; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KIES, MARIAN W.
AU - DRISCOLL, BERNARD F.
AU - SEIL, FREDRICK J.
AU - ALVORD JR., ELLSWORTH C.
T1 - Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis.
JO - Science
JF - Science
Y1 - 1973/02/16/
VL - 179
IS - 4074
M3 - Article
SP - 689
EP - 690
SN - 00368075
AB - Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum." [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158281; KIES, MARIAN W. 1; DRISCOLL, BERNARD F. 1; SEIL, FREDRICK J. 2; ALVORD JR., ELLSWORTH C. 3; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Neurology, Stanford University School of Medicine, and Veterans Administration Hospital, Palo Alto, California 94304; 3: Department of Pathology, University of Washington School of Medicine, Seattle 98195; Issue Info: 2/16/1973, Vol. 179 Issue 4074, p689; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Peele, R.;
AU - Von Loetzen, I. S.;
T1 - Phenothiazine deaths: a critical review
CT - Phenothiazine deaths: a critical review
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/03/01/
VL - 130
IS - Mar
SP - 306
EP - 309
SN - 0002953X
AD - Area D Community Mental Health Center of Saint Elizabeths Hospital, National Institute of Mental Health, Washington, D. C. 20032
N1 - Accession Number: 10-4493; Language: English; References: 17; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Toxicity
N2 - A comparison of the sudden, unexplained deaths attributed to phenothiazines with those of sudden, unexplained deaths attributed to lethal catatonia is presented. To determine whether ""phenothiazine death'' is a valid entity, the authors examined case studies in the literature for other explanations of these sudden, unexpected, autopsy-negative deaths. The results of their comparisons of a large number of phenothiazine deaths and deaths due to lethal catatonia raise doubts as to the validity of phenothiazine death as an entity.
KW - Phenothiazines--death--comparison, lethal catatonia, in patients;
KW - Psychotherapeutic agents--phenothiazines--death, comparison, lethal catatonia, in patients;
KW - Toxicity--phenothiazines--lack, on sudden death, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Chafetz, Morris E.
T1 - New Federal Legislation on Alcoholism--Opportunities and Problems.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/03//
VL - 63
IS - 3
M3 - Article
SP - 206
EP - 208
PB - American Public Health Association
SN - 00900036
AB - Recognition of alcoholism as a complex problem involving medical, social and environmental factors is exemplified by new legislation for prevention, treatment and rehabilitation. Ways and means of implementing this legislation are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental engineering
KW - Liquor laws
KW - Prevention of alcoholism
KW - Drinking of alcoholic beverages
KW - Alcoholics -- Legal status, laws, etc.
KW - Federal legislation
KW - Legislative bills
KW - Social interaction
KW - Ergonomics
KW - United States
N1 - Accession Number: 24294427; Chafetz, Morris E. 1; Affiliations: 1: Director, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, Rockville, Maryland 20852; Issue Info: Mar1973, Vol. 63 Issue 3, p206; Thesaurus Term: Environmental engineering; Subject Term: Liquor laws; Subject Term: Prevention of alcoholism; Subject Term: Drinking of alcoholic beverages; Subject Term: Alcoholics -- Legal status, laws, etc.; Subject Term: Federal legislation; Subject Term: Legislative bills; Subject Term: Social interaction; Subject Term: Ergonomics; Subject: United States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 312140 Distilleries; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Winkler, J. W., Jr.;
AU - Deisseroth, A. B.;
AU - Morganroth, J.;
T1 - Quinidine hepatotoxicity?
CT - Quinidine hepatotoxicity?
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/03/01/
VL - 78
IS - Mar
SP - 460
SN - 00034819
AD - National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 10-3689; Language: English; Trade Name: Surfak; Generic Name: Dioctyl calcium sulfosuccinate; Chemical Name: Quinidine--56-54-2; Therapeutic Class: (56:12); AHFS Class: Cathartics dioctyl calcium sulfosuccinate (24:04); AHFS Class: Cardiac drugs quinidine; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Judith A. Kepler
N2 - In 2 letters to the editor, the possiblity of an interaction between quinidine and dioctyl calcium sulfosuccinate (Surfak) resulting in hepatotoxicity is debated.
KW - Quinidine--interactions-;
KW - Dioctyl calcium sulfosuccinate--interactions-;
KW - Cathartics--dioctyl calcium sulfosuccinate--interactions, quinidine, hepatotoxicity, discussion, in humans;
KW - Cardiac drugs--quinidine--interactions, dioctyl calcium sulfosuccinate, hepatotoxicity, discussion, in humans;
KW - Drug interactions--quinidine and dioctyl calcium sulfosuccinate--hepatotoxicity, discussion, in humans;
KW - Drug interactions--dioctyl calcium sulfosuccinate and quinidine--hepatotoxicity, discussion, in humans;
KW - Toxicity--quinidine--hepatotoxicity, possible interaction with dioctyl calcium sulfosuccinate, in humans;
KW - Toxicity--dioctyl calcium sulfosuccinate--hepatotoxicity, possible interactions with quinidine, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kotin, J.;
AU - Post, R. M.;
AU - Goodwin, F. K.;
T1 - \D/\SU/9\BS/-Tetrahydrocannabinol in depressed patients
CT - \D/\SU/9\BS/-Tetrahydrocannabinol in depressed patients
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/03/01/
VL - 28
IS - Mar
SP - 345
EP - 348
AD - Reprints: Orange County Medical Center, 101 City Drive, Orange, California 92668
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 11-2120; Language: English; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants tetrahydrocannabinol; References: 17; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - A double-blind study on 8 depressed patients, who received oral \D/\SU/9\BS/ tetrahydrocannabinol at a dose of 0.3 mg./kg. 2 times a day for up to 7 days, failed to produce significant euphoria or an antidepressant response. Two patients experienced severe anxiety reactions with depersonalization after one dose and 2 others suffered adversities which lead to their early termination from the study. Four patients showed little change in mood but reported drowsiness.
KW - Tetrahydrocannabinol--depression-;
KW - Antidepressants--tetrahydrocannabinol--lack, effects, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Horton, J. E.
AU - Oppenheim, J. J.
AU - Mergenhagen, S. E.
T1 - ELABORATION OF LYMPHOTOXIN BY CULTURED HUMAN PERIPHERAL BLOOD LEUCOCYTES STIMULATED WITH DENTAL-PLAQUE DEPOSITS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1973/03//
VL - 13
IS - 3
M3 - Article
SP - 383
EP - 393
PB - Wiley-Blackwell
SN - 00099104
AB - Leucocyte cultures from subjects with periodontal disease when stimulated by human dental-plaque deposit material, or phytohaemagglutinin, produce a soluble factor, lymphotoxin, which is cytotoxic for fibroblasts in vitro. The cytotoxic effect was determined from the degree of inhibition of incorporation of 14C-labelled L-leucine by in vitro cultures of human gingival or mouse L-fibroblasts exposed to supernatants from such cultures. Inhibition of protein synthesis by the fibroblasts was not due to either depletion of nutrients or direct toxicity of the antigenic dental- plaque material. Both plaque-stimulated leucocyte culture supernatants from clinically normal subjects and unstimulated leucocyte culture supernatants from subjects with periodontal disease were significantly less inhibitory than super- natants of plaque-stimulated leucocyte cultures from subjects with periodontal disease. This production of lymphotoxin by leucocytes stimulated with antigen(s) present in dental plaque-deposits may reflect a mechanism of tissue destruction by sensitized lymphocytes present in the tissues of subjects with periodontal disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - LEUCOCYTES
KW - PERIODONTAL disease
KW - BLOOD cells
KW - FIBROBLASTS
KW - KILLER cells
N1 - Accession Number: 14544572; Horton, J. E. 1 Oppenheim, J. J. 1 Mergenhagen, S. E. 1; Affiliation: 1: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1973, Vol. 13 Issue 3, p383; Subject Term: TUMOR necrosis factor; Subject Term: LEUCOCYTES; Subject Term: PERIODONTAL disease; Subject Term: BLOOD cells; Subject Term: FIBROBLASTS; Subject Term: KILLER cells; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Cornelis, W. A.;
AU - Christian, D. G.;
AU - Fortner, C. L.;
T1 - Hodgkin's disease
CT - Hodgkin's disease
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1973/03/01/
VL - NS13
IS - Mar
SP - 147
EP - 154
AD - Patient Care Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, U.S. Public Health Service Hospital, Baltimore, Maryland
N1 - Accession Number: 12-6205; Language: English; References: 6; Publication Type: Current Therapeutic Concepts; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Drucella Andersen
N2 - The pathology; staging; clinical course and complications; therapy, including radiation treatments and chemotherapy; and prognosis of Hodgkin's disease is presented.
KW - Hodgkin's disease--therapy--discussion, in patients;
KW - Radiation--Hodgkin's disease--chemotherapy, discussion, in patients;
KW - Nomenclature--Hodgkin's disease--discussion;
KW - Antineoplastic agents--Hodgkin's disease--therapy, discussion, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Layard, M. W. J.
T1 - Robust Large-Sample Tests for Homogeneity of Variances.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1973/03//
VL - 68
IS - 341
M3 - Article
SP - 195
SN - 01621459
AB - Two asymptotically robust tests for equality of variances in the k-sample case are discussed: a simple x[sup t] test and a test based on the jackknife procedure. Some Monte Carlo experiments suggest that these tests are reasonably robust for moderately small samples, are more powerful than Box's grouping test and perform similarly to Bartlett's test in the normal case. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VARIANCES
KW - MONTE Carlo method
KW - DISTRIBUTION (Probability theory)
KW - MATHEMATICAL statistics
KW - ROBUST statistics
KW - HOMOSCEDASTICITY
KW - SAMPLE size (Statistics)
KW - JACKKNIFE (Statistics)
KW - HOMOGENEITY
N1 - Accession Number: 4606320; Layard, M. W. J. 1; Affiliations: 1: Senior Staff Fellow, Mathematical Statistics Section, National Cancer Institute, Bethesda, Maryland 20014.; Issue Info: Mar1973, Vol. 68 Issue 341, p195; Thesaurus Term: VARIANCES; Thesaurus Term: MONTE Carlo method; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MATHEMATICAL statistics; Subject Term: ROBUST statistics; Subject Term: HOMOSCEDASTICITY; Subject Term: SAMPLE size (Statistics); Subject Term: JACKKNIFE (Statistics); Subject Term: HOMOGENEITY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Weisburger, J. H.;
AU - Weisburger, E. K.;
T1 - Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids
CT - Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids
JO - Pharmacol. Rev.
JF - Pharmacol. Rev.
Y1 - 1973/03/01/
VL - 25
IS - Mar
SP - 1
EP - 6
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-0882; Language: English; References: 519; Journal Coden: PAREAQ; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - A review of the effects of aromatic and aliphatic hydroxylamines and hydroxamic acids on the hematopoietic system and their mutagenic, carcinogenic and toxic activities is presented. In vitro and enzymatic studies provide greater understanding and insight into the importance of amine metabolism and pathological properties.
KW - Hydroxylamines--effects--hematopoietic system, and toxicity, in animals;
KW - Hydroxamic acids--effects--hematopoietic system, and toxicity, in animals;
KW - Toxicity--hydroxylamines--carcinogenicity, and mutation, in animals;
KW - Toxicity--hydroxamic acids--carcinogenicity, and mutation, in animals;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2005-09606-001
AN - 2005-09606-001
AU - Rawlings, Robert R. Jr.
T1 - Comments on the Overall and Spiegel Paper.
JF - Psychological Bulletin
JO - Psychological Bulletin
JA - Psychol Bull
Y1 - 1973/03//
VL - 79
IS - 3
SP - 168
EP - 169
CY - US
PB - American Psychological Association
SN - 0033-2909
SN - 1939-1455
AD - Rawlings, Robert R. Jr., Health Service sand Mental Health Administration, National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1 - Accession Number: 2005-09606-001. Partial author list: First Author & Affiliation: Rawlings, Robert R. Jr.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Analysis of Variance. Classification: Psychometrics & Statistics & Methodology (2200). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 1973. Copyright Statement: American Psychological Association. 1973.
AB - Responds to the comments by J. F. Overall and D. K. Spiegel (see record [rid]1973-20070-001[/rid]) on the current author's original article 'Note on nonorthogonal analysis of variance' (see record [rid]1972-26084-001[/rid]). The purpose of this note is the clarification of certain erroneous interpretations concerning the nonorthogonal analysis of variance which appear in the comment by Overall and Spiegel. This note demonstrates that the method proposed by Overall and Spiegel and the method proposed by the current author are not equivalent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nonorthogonal analysis of variance
KW - 1973
KW - Analysis of Variance
KW - 1973
DO - 10.1037/h0020025
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GUIDOTTI, A.
AU - COSTA, E.
T1 - Involvement of Adenosine 3',5'-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs.
JO - Science
JF - Science
Y1 - 1973/03/02/
VL - 179
IS - 4076
M3 - Article
SP - 902
EP - 904
SN - 00368075
AB - Immediately after the injection of reserpine (16 micromoles per kilogram, intraperitoneally), aminophylline (200 micromoles per kilogram, intraperitoneally), and carbamylcholine (8.2 micromoles per kilogram, intraperitoneally), the concentration of adenosine 3',5'-monophosphate in adrenal medulla of rats is increased severalfold. The three drugs also cause a delayed increase of medullary tyrosine hydroxylase activity. Our results are consistent with the view that an increase of medullary adenosine 3',5'-monophosphate concentration is involved in the drug-induced increase of tyrosine hydroxylase activity adrenal medulla. Experiments with tyramine (130 micromoles per kilogram intraperitoneally) suggest that the increase of tyrosine hydroxylase activity and of adenosine 3',5'-monophosphate concentrations is independent of an increase in adrenal catecholamine turnover rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158363; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p902; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILLER, A. L.
AU - HAWKINS, R. A.
AU - VEECH, R. L.
T1 - Phenylketonuria: Phenylalanine Inhibits Brain Pyruvate Kinase in vivo.
JO - Science
JF - Science
Y1 - 1973/03/02/
VL - 179
IS - 4076
M3 - Article
SP - 904
EP - 906
SN - 00368075
AB - The hypothesis that brain damage in phenylketonuria is related to inhibition of pyruvate kinase by phenylalanine was examined in rat brain in vivo. One hour after a single injection of phenylalanine into the rat, the brains were removed and completely frozen in less than a second. The concentration of phenylalanine in the brain was comparable to that found in phenylketonuric patients. Changes in brain glycolytic intermediates were consistent with inhibition of pyruvate kinase in vivo. The inhibition of pyruvate kinase was apparently compensated for by an increase in phosphoenolpyruvate; no decrease in adenosine triphosphate or creatine phosphate was found. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158364; MILLER, A. L. 1; HAWKINS, R. A. 1; VEECH, R. L. 1; Affiliations: 1: Section on Neurochemistry, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p904; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NAI-SHIN CHU
AU - BLOOM, FLOYD E.
T1 - Norepinephrine-Containing Neurons: Changes in Spontaneous Discharge Patterns during Sleeping and Waking.
JO - Science
JF - Science
Y1 - 1973/03/02/
VL - 179
IS - 4076
M3 - Article
SP - 908
EP - 910
SN - 00368075
AB - Norepinephrine-containing neurons of the locus coeruleus of the cat were recorded with mnicroelectrodes during unrestrained sleeping and waking. The recorded neurons were subsequently defined by combined fluorescence histochemiiistry of catecholamnines and production of microlesions at recording sites. These pontine units show homtiogeneous changes in discharge patterns with respect to sleep stages, firing slowly during drowsy periods and slow wave sleep and firing in rapid bursts during paradoxical sleep. These data provide a direct correlation between the activity of defined catecholamiine-containing neurons and the spontaneous occurrence of sleep stages. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158366; NAI-SHIN CHU 1; BLOOM, FLOYD E. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p908; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYATT, R. J.
AU - MURPHY, D. L.
AU - BELMAKER, R.
AU - COHEN, S.
AU - DONNELLY, C. H.
AU - POLLIN, W.
T1 - Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia.
JO - Science
JF - Science
Y1 - 1973/03/02/
VL - 179
IS - 4076
M3 - Article
SP - 916
EP - 918
SN - 00368075
AB - Monoamine oxidase activity in blood platelets was measured, with [14C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers. The monoamine oxidase activity of both schizophrenic and nonschizophrenic co-twins was significantly lower than it was for the normals, and it was highly correlated between twins. In addition, there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity. These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158371; WYATT, R. J. 1; MURPHY, D. L. 1; BELMAKER, R. 1; COHEN, S. 1; DONNELLY, C. H. 1; POLLIN, W. 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/ 2/1973, Vol. 179 Issue 4076, p916; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Levine, A. S.;
AU - Siegel, S. E.;
AU - Schreiber, A. D.;
AU - Hauser, J.;
AU - Preisler, H.;
AU - \ET/;
T1 - Protected environments and prophylactic antibiotics: a prospective controlled study of their utility in the therapy of acute leukemia
CT - Protected environments and prophylactic antibiotics: a prospective controlled study of their utility in the therapy of acute leukemia
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1973/03/08/
VL - 288
IS - Mar 8
SP - 477
EP - 483
SN - 00284793
AD - Building 10, Room 6B06, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 10-3238; Language: English; Chemical Name: Gentamicin--1403-66-3 Vancomycin--1404-90-6 Nystatin--1400-61-9; References: 39; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - To reduce the frequency of infection in acute leukemia, an isolation and air filtration facility (protected environment) and a prophylactic regimen that included oral nonabsorbable antibiotics was instituted. Eighty-eight randomized patients received identical remission induction chemotherapy within one of 3 groups: protected environment combined with the prophylactic regimen (group 1); oral nonabsorbable antibiotics alone (group 2); and neither isolation nor prophylaxis (group 3). Antibiotics used were gentamicin, vancomycin and nystatin. The groups were comparable in factors that might influence the course of leukemia and susceptibility to infection. Environmental maneuvers were effective in reducing the potential inoculum of ambient microorganisms. Patients in group 1 had half as many severe infections as those in groups 2 and 3. Whereas approximately 25% of the patients in groups 2 and 3 died of infection while on study, none in group 1 died for that reason. Despite fewer infections in group 1, no intergroup differences were found in remission rate or duration. The results indicate that the use of oral nonabsorbable antibiotics alone did not reduce the frequency of severe infection or the rate of deaths in which infection was the proximate cause.
KW - Gentamicin--combination, vancomycin, nystatin-;
KW - Vancomycin--combination, gentamicin, nystatin-;
KW - Nystatin--combination, gentamicin, vancomycin-;
KW - Antibiotics--combined therapy--infections, reduction, lack of effect, in leukemic patients;
KW - Combined therapy--antibiotics--infections, reduction, lack of effect, in leukemic patients;
KW - Infections--prophylaxis--antibiotics, combined therapy, lack of effect, in leukemic patients;
KW - Toxicity, environmental--infections--hospitals, prophylaxis, combined antibiotic therapy lacks effect, in leukemic patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - POST, ROBERT M.
AU - GORDON, EDNA K.
AU - GOODWIN, FREDERICK K.
AU - BUNNEY JR., WILLIAM E.
T1 - Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid.
JO - Science
JF - Science
Y1 - 1973/03/09/
VL - 179
IS - 4077
M3 - Article
SP - 1002
EP - 1003
SN - 00368075
AB - Concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl glycol in cerebrospinal fluid were measured by a gas chromatographic method in 34 patients with affective illness and in 44 controls. Concentrations of this metabolite in spinal fluid were significantly lower in depressed patients than in controls or manic patients. These low values may occur secondary to depressive phenomena such as reduced psychomotor activity, or they may reflect a primary change in norepinephrine metabolism in depressive illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158403; POST, ROBERT M. 1; GORDON, EDNA K. 1; GOODWIN, FREDERICK K. 1; BUNNEY JR., WILLIAM E. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/ 9/1973, Vol. 179 Issue 4077, p1002; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROSENTHAL, DAVID
T1 - Etiology of Psychosis.
JO - Science
JF - Science
Y1 - 1973/03/16/
VL - 179
IS - 4078
M3 - Article
SP - 1117
EP - 1118
SN - 00368075
N1 - Accession Number: 85158433; ROSENTHAL, DAVID 1; Affiliations: 1: Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 3/16/1973, Vol. 179 Issue 4078, p1117; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DELONG, M. R.
T1 - Putamen: Activity of Single Units during Slow and Rapid Arm Movements.
JO - Science
JF - Science
Y1 - 1973/03/23/
VL - 179
IS - 4079
M3 - Article
SP - 1240
EP - 1242
SN - 00368075
AB - The activity of putamen neurons was studied in a monkey during the performance of both slow and rapid arm movements. More than half of all movement-related units discharged preferentially in relation to slow movements and less than 10 percent in relation to rapid movements. These findings indicate that at least a portion of the basal ganglia (the putamen) is primarily involved in the control of slow movements and are consistent with the hypothesis of Kornhuber that the primary motor function of the basal ganglia is to generate slow ("ramp") rather than rapid ("ballistic") movements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158487; DELONG, M. R. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/23/1973, Vol. 179 Issue 4079, p1240; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GILLESPIE, D.
AU - TAKEMOTO, K.
AU - ROBERT, M.
AU - GALLO, R. C.
T1 - Polyadenylic Acid in Visna Virus RNA.
JO - Science
JF - Science
Y1 - 1973/03/30/
VL - 179
IS - 4080
M3 - Article
SP - 1328
EP - 1330
SN - 00368075
AB - Visna virus 70S RNA colllains long stretches of polyadenylic acid [poly(A)]. The homogeneity in length of poly( 4) regions is observed in 70S RNA from visna virus and all RNA tumor viruses tested, and not with other types of RNA. By this criterion visna virus resembles RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117058; GILLESPIE, D. 1; TAKEMOTO, K. 2; ROBERT, M. 3; GALLO, R. C. 3; Affiliations: 1: Litton Bionetics, Inc., Bethesda, Maryland 20014; 2: Laboratory of Viral Disease, National Institute of Allergy and Infectious Diseases, Bethesda 20014; 3: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda 20014; Issue Info: 3/30/1973, Vol. 179 Issue 4080, p1328; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CARPENTER, DAVID O.
T1 - Electrogenic Sodium Pump and High Specific Resistance in Nerve Cell Bodies of the Squid.
JO - Science
JF - Science
Y1 - 1973/03/30/
VL - 179
IS - 4080
M3 - Article
SP - 1336
EP - 1338
SN - 00368075
AB - An electrogenic sodium pump contributes to the membrane potential in squid nerve cell bodies, imparting a temperature dependence to the resting potential that is abolished by strophanthidin. The existence of a potential produced by the pump in the soma but not the axon is correlated with a higher membrane resistance in the soma. Thus, membranes from different parts of a neuron may have functionally significant differences in resistance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117063; CARPENTER, DAVID O. 1,2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 3/30/1973, Vol. 179 Issue 4080, p1336; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Blum, R. H.;
AU - Carter, S. K.;
AU - Agre, K.;
T1 - Clinical review of bleomycin\M/new antineoplastic agent
CT - Clinical review of bleomycin\M/new antineoplastic agent
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1973/04/01/
VL - 31
IS - Apr
SP - 903
EP - 914
AD - Cancer Therapy Evaluation Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-2955; Language: English; Chemical Name: Bleomycin--11056-06-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents bleomycin; References: 26; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A review of data from clinical trials of bleomycin in 1,174 patients, summarized by cell type, is presented. The most commonly used dose schedule was 15 mg./sq. m. I.V. twice weekly. Significant response rates were achieved in patients with squamous cell carcinoma of various anatomical sites, lymphomas, and testicular carcinoma. Most responses were of 1 to 2 months duration. Drug toxicities included significant skin and pulmonary complications and some degree of drug induced pyrexia and nausea with vomiting. Rate insignificant bone marrow depression was encountered. The limitations of a retrospective clinical review of this type using uncontrolled pooled data from various patient populations were discussed. In conclusion, bleomycin appeared to be useful in the treatment of patients with specific tumors refractory to standard treatment and/or whose bone marrow status precluded the use of conventional chemotherapy.
KW - Bleomycin--cancer-;
KW - Antineoplastic agents--bleomycin--cancer, therapy, statistics, review;
KW - Statistics--bleomycin--cancer, therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Sherwood, G.
AU - Blaese, R. M.
T1 - PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXIC EFFECTOR LYMPHOCYTE FUNCTION IN PATIENTS WITH THE WISKOTT-ALDRICH SYNDROME (WAS).
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1973/04//
VL - 13
IS - 4
M3 - Article
SP - 515
EP - 520
PB - Wiley-Blackwell
SN - 00099104
AB - Patients with the Wiskott-Aldrich syndrome have immunodeficiency characterized by defective antibody production and clinical anergy. In vitro lymphocyte proliferative responses to non-specific mitogens in these patients, however, are normal. To determine if their anergy might be the result of failure to produce cytotoxic effector lymphocytes, peripheral blood leucocytes were cultured with 51Cr-labelled chicken erythrocyte targets in the presence of PHA. Lymphocytes from patients with the Wiskott-Aldrich syndrome had normal PHA induced cytotoxicity responses and this result is discussed in relation to a postulated defect in the afferent limb of the immune response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNODEFICIENCY
KW - SYNDROMES
KW - LEUCOCYTES
KW - MITOGENS
KW - LYMPHOCYTES
KW - BLOOD cells
N1 - Accession Number: 14544933; Sherwood, G. 1 Blaese, R. M. 1; Affiliation: 1: National Cancer Institute and Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Apr73, Vol. 13 Issue 4, p515; Subject Term: IMMUNODEFICIENCY; Subject Term: SYNDROMES; Subject Term: LEUCOCYTES; Subject Term: MITOGENS; Subject Term: LYMPHOCYTES; Subject Term: BLOOD cells; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eaertzen, Charles A.
AU - Hooks Jr., Nali T.
T1 - DICTIONARY OF DRUG ASSOCIATIONS TO HEROIN, BENZEDRINE, ALCOHOL, BARBITURATES AND MARIJUANA.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1973/04//
VL - 29
IS - 2
M3 - Article
SP - 115
EP - 164
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses a dictionary of drug associations to heroin, benzedrine, alcohol, barbiturates and marijuana. A 3500 word dictionary of drug associations was constructed by having 20 or more opiate addicts associate words to heroin, benzedrine, alcohol, goof balls, and reefers. Broad sampling of words was attempted through selection of the 1000 most frequently used English words. The dictionary may be useful as a resource for the selection of words for studies of conditioning, verbal learning, perception, or individual differences, cues for possible educational objectives on drugs, evaluation of the drug relatedness of words chosen for experiments by some non-dictionary criteria, and as a standard to compare the associational values of other drug users or addictive types with different presumed habit strengths.
KW - ENCYCLOPEDIAS & dictionaries
KW - DRUG abuse
KW - DRUGS of abuse
KW - MARIJUANA
KW - ALCOHOL
KW - VOCABULARY
N1 - Accession Number: 15844507; Eaertzen, Charles A. 1 Hooks Jr., Nali T. 1; Affiliation: 1: National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky.; Source Info: Apr1973, Vol. 29 Issue 2, p115; Subject Term: ENCYCLOPEDIAS & dictionaries; Subject Term: DRUG abuse; Subject Term: DRUGS of abuse; Subject Term: MARIJUANA; Subject Term: ALCOHOL; Subject Term: VOCABULARY; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 50p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taussig, Lynn M.
AU - Braunstein, Glenn D.
T1 - EFFECTS OF VASOPRESSIN ON SWEAT RATE AND COMPOSITION IN PATIENTS WITH DIABETES INSIPIDUS AND NORMAL CONTROLS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1973/04//
VL - 60
IS - 4
M3 - Article
SP - 197
EP - 202
SN - 0022202X
AB - Baseline sweat rate and concentrations of sodium, chloride, and potassium, and the effect of exogenous vasopressin on these parameters were determined in 13 patients with acquired diabetes insipidus (ADI), four patients with nephrogenic diabetes insipidus (NDI), three subjects with cystic fibrosis, and age- and sex-matched controls. The four patients with NDI did not differ from the controls with respect to baseline sweat rate, but baseline sodium, chloride, and potassium concentrations were significantly elevated. In addition, parenteral vasopressin caused a significant decrease in sweat rate (p < .01) while the electrolyte concentrations remained unchanged. This indicates that vasopressin may also have an effect on electrolyte reabsorption in NDI patients. Alternatively, the amount of sweat precursor fluid may have been reduced. The patients with ADI did not differ from the controls with respect to baseline data, and parenteral vasopressin had no effect on their sweat rate and composition. Likewise, vasopressin had no effect in controls or patients with cystic fibrosis. We conclude that, except in patients with NDI, vasopressin does not play a significant role in the regulation of human eccrine sweating. Sweat gland physiology appears to be different in patients with NDI and in them vasopressin may have a significant effect on sweat. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VASOPRESSIN
KW - PERSPIRATION
KW - SWEAT glands
KW - SODIUM
KW - CHLORIDES
KW - DIABETES
N1 - Accession Number: 12724468; Taussig, Lynn M. 1 Braunstein, Glenn D. 2; Affiliation: 1: Pediatric Metabolism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institute of Health, Bethesda, Maryland, 20014. 2: Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014.; Source Info: Apr73, Vol. 60 Issue 4, p197; Subject Term: VASOPRESSIN; Subject Term: PERSPIRATION; Subject Term: SWEAT glands; Subject Term: SODIUM; Subject Term: CHLORIDES; Subject Term: DIABETES; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12724468
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Cradock, J. C.;
AU - Davignon, J. P.;
AU - Litterst, C. L.;
AU - Guarino, A. M.;
T1 - Intravenous formulation of delta-9-tetrahydrocannabinol using a nonionic surfactant
CT - Intravenous formulation of delta-9-tetrahydrocannabinol using a nonionic surfactant
JO - Journal of Pharmacy and Pharmacology (England)
JF - Journal of Pharmacy and Pharmacology (England)
Y1 - 1973/04/01/
VL - 25
IS - Apr
SP - 345
SN - 03731022
AD - Drug Development Branch and Laboratory of Toxicology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-0086; Language: English; Publication Type: Letters; Journal Coden: JPPMAB; Section Heading: Pharmaceutics
KW - Tetrahydrocannabinol--injections-;
KW - Formulations--tetrahydrocannabinol--injections, I.V., using nonionic surfactant;
KW - Injections--tetrahydrocannabinol--intravenous, formulations, using nonionic surfactant;
KW - Surface active agents--nonionic--in I.V. formulation of tetrahydrocannabinol;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bennett, J. E.;
T1 - Treatment of systemic mycoses
CT - Treatment of systemic mycoses
JO - Ration. Drug Ther.
JF - Ration. Drug Ther.
Y1 - 1973/04/01/
VL - 7
IS - Apr
SP - 1
EP - 4
AD - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
N1 - Accession Number: 11-1721; Language: English; Trade Name: Ancobon; Generic Name: Flucytosine; Chemical Name: Amphotericin B--1397-89-3 Nystatin--1400-61-9 Flucytosine--2022-85-7; Therapeutic Class: (8:12.04); AHFS Class: Fungicides flucytosine (8:12.04); AHFS Class: Fungicides hydroxystilbamidine; Journal Coden: RDGTAP; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: James W. Cooper, Jr.
N2 - A discussion of the use, pharmacology, toxicity, physical properties and dosing of the polyene antibiotics (amphotericin B and nystatin), flucytosine (Ancobon), hydroxystilbamidine and iodide in systemic and cutaneous mycoses is presented.
KW - Amphotericin B--mycoses-;
KW - Nystatin--mycoses-;
KW - Flucytosine--mycoses-;
KW - Hydroxystilbamidine--mycoses-;
KW - Iodides--mycoses--systemic, therapy, discussion;
KW - Toxicity--drugs--mycoses, systemic, therapy, discussion;
KW - Fungicides--flucytosine--mycoses, systemic, therapy, discussion;
KW - Fungicides--hydroxystilbamidine--mycoses, systemic, therapy, discussion;
KW - Fungicides--iodide--mycoses, systemic, therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-41559-008
AN - 2013-41559-008
AU - Nelson, Scott H.
AU - Torrey, E. Fuller
T1 - The religious functions of psychiatry.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/04//
VL - 43
IS - 3
SP - 362
EP - 367
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Nelson, Scott H., 3125 North Eighth Street, Arlington, VA, US, 22201
N1 - Accession Number: 2013-41559-008. PMID: 4711078 Partial author list: First Author & Affiliation: Nelson, Scott H.; Health Services and Mental Health Administration, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Psychiatry; Religion; Religious Practices; Social Values. Minor Descriptor: Mental Health Personnel. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1973.
AB - Three functions traditionally recognized as being in the domain of religion are increasingly being assumed by mental health practitioners: 1) explanation of the unknown; 2) ritual and social functions; and 3) the definition of values. The authors recommend that religious and mental health practitioners define their functions and roles more clearly, so that they may interact more constructively (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - religious functions
KW - psychiatry
KW - mental health practitioners
KW - ritual functions
KW - religious values
KW - 1973
KW - Psychiatry
KW - Religion
KW - Religious Practices
KW - Social Values
KW - Mental Health Personnel
KW - 1973
DO - 10.1111/j.1939-0025.1973.tb00806.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GERWIN, BRENDA I.
AU - EBERT, PAUL S.
AU - CHOPRA, HARISH C.
AU - SMITH, SUSAN G.
AU - KVEDAR, JOHN P.
AU - ALBERT, SAM
AU - BRENNAN, MICHAEL J.
T1 - DNA Polymerase Activities of Human Milk.
JO - Science
JF - Science
Y1 - 1973/04/13/
VL - 180
IS - 4082
M3 - Article
SP - 198
EP - 201
SN - 00368075
AB - DNA polymerases have been partially purified from human milk. A DNA polymerase detected by phosphocellulose chromatography is similar to the enzymes of RNA tumor viruses in that a hybrid of polyriboadenylate and oligodeoxythymidylate is a better template than is DNA. However, this polymerase differed from that of the RNA tumor viruses in its chromatographic behavior. Three different methods of detecting "reverse transcriptase" activity failed to correlate with the donor's family history of cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178607; GERWIN, BRENDA I. 1; EBERT, PAUL S. 1; CHOPRA, HARISH C. 1; SMITH, SUSAN G. 1; KVEDAR, JOHN P. 1; ALBERT, SAM 2; BRENNAN, MICHAEL J. 2; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; 2: Michigan Cancer Foundation, Detroit 48201; Issue Info: 4/13/1973, Vol. 180 Issue 4082, p198; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - UZUNOV, PETKO
AU - SHEIN, HARVEY M.
AU - WEISS, BENJAMIN
T1 - Cyclic AMP Phosphodiesterase in Cloned Astrocytoma Cells: Norepinephrine Induces a Specific Enzyme Form.
JO - Science
JF - Science
Y1 - 1973/04/20/
VL - 180
IS - 4083
M3 - Article
SP - 304
EP - 306
SN - 00368075
AB - The soluble supernatant fraction of homogenates of cloned rat astrocytoma cells (line C-2A) was subjected to polyacrylamide gel electrophoresis. Two peaks of adenosine 3',5'-monophosphate phosphodiesterase activity were found, corresponding to peaks I and IV of a similarly prepared homogenate of rat brain. Incubating cells with norepinephrine (0.3 mullimolar) caused about a threefold increase in the activity of peak IV but no change in peak I. This increase was completely inhibited by prior inclubation with propranolol (0.1 millimnolar), a beta-adrenergic blocking agent, or with cyclohexamnine (40 micromolar). a protein synthesis inhibitor. Induction of a specific phosphodiesterase form by norepinephrine sitggests another feedback control mechanism whereby an organism can prevent the effects of excessive sympathetic activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136011; UZUNOV, PETKO 1; SHEIN, HARVEY M. 2; WEISS, BENJAMIN 3,4; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: McLean Hospital, Belmont, Maassachusetts 02178; 3: Laboratory of Preclinical Pharmacology, National Institute of Mental Health; 4: Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129; Issue Info: 4/20/1973, Vol. 180 Issue 4083, p304; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TYERYAR JR., FRANKLIN J.
AU - WEISS, EMILIO
AU - MILLAR, DAVID B.
AU - BOZEMAN, F. MARILYN
AU - ORMSBEE, RICHARD A.
T1 - DNA Base Composition of Rickettsiae.
JO - Science
JF - Science
Y1 - 1973/04/27/
VL - 180
IS - 4084
M3 - Article
SP - 415
EP - 417
SN - 00368075
AB - There is a small but distinct difference in DNA base composition between the typhus and spotted fever groups of rickettsiae. The molar percentages of guanine plus cytosine for Rickettsia prowazeki, R. typhi, and R. canada are approximately 30, for R. rickettsi, R. conori, and R. akari they are about 32.5. The percentage for trench fever rickettsia, Rochalimaea quintana, is 38.6. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158527; TYERYAR JR., FRANKLIN J. 1; WEISS, EMILIO 1; MILLAR, DAVID B. 1; BOZEMAN, F. MARILYN 2; ORMSBEE, RICHARD A. 3; Affiliations: 1: Naval Medical Research Institute, Bethesda, Maryland, 20014; 2: Walter Reed Army Institute of Research, Washington, D.C., 20012; 3: National Institute of Allergy and Infectious Diseases, Hamilton, Montana, 59840; Issue Info: 4/27/1973, Vol. 180 Issue 4084, p415; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TING, KAI-LI H.
AU - LEE, R. C. T.
AU - MILNE, G. W. A.
AU - SHAPIRO, M.
AU - GUARINO, A. M.
T1 - Applications of Artificial Intelligence: Relationships between Mass Spectra and Pharmacological Activity of Drugs.
JO - Science
JF - Science
Y1 - 1973/04/27/
VL - 180
IS - 4084
M3 - Article
SP - 417
EP - 420
SN - 00368075
AB - The possibility that the mass spectrum and pharmacological activity of a compound may be directly related has been explored with the help of various computer-based pattern-recognition techniques. The relationship appears to hold at least for tranquilizers and sedatives, and compounds with one or the other of these two pharmacological activities can thus be classified from their mass spectra with a high degree of accuracy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158528; TING, KAI-LI H. 1; LEE, R. C. T. 1; MILNE, G. W. A. 1; SHAPIRO, M. 1; GUARINO, A. M. 1; Affiliations: 1: Division of Computer Research and Technology, National Cancer Institute and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014; Issue Info: 4/27/1973, Vol. 180 Issue 4084, p417; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Greenhill, L. L.;
AU - Rieder, R. O.;
AU - Wender, P. H.;
AU - Buchsbaum, M.;
AU - Zahn, T. P.;
T1 - Lithium carbonate in the treatment of hyperactive children
CT - Lithium carbonate in the treatment of hyperactive children
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/05/01/
VL - 28
IS - May
SP - 636
EP - 640
AD - (Reprints: Rousso Building, 1165 Morris Park Avenue, Bronx, New York 10461
AD - National Institute of Mental Health, Laboratory of Psychology, Bethesda, Maryland
N1 - Accession Number: 11-1060; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 15; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Lithium carbonate, in 150 mg. doses that reached a blood level of 0.8 to 1.2 meq./l. was tested in 9 severely hyperactive children who were unresponsive to stimulant medication. In the 3-month modified double-blind trial, lithium carbonate was alternated with dextroamphetamine or placebo. Six children showed no improvement or a worsening of symptoms when given lithium carbonate and one dropped out of the study. Two children who improved transiently had been observed to have effective symptoms and differed on psychophysiological measures from the rest of the group.
KW - Lithium carbonate--hyperkinesis-;
KW - Psychotherapeutic agents--lithium carbonate--hyperkinesis, lack of effects, in children;
KW - Blood levels--lithium carbonate--hyperkinesis, lack of effect, in children;
KW - Metabolism--lithium carbonate--blood levels, hyperkinesis, lack of effect, in children;
KW - Hyperkinesis--lithium carbonate--lack, effects, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hochstein, H. D.;
AU - Elin, R. J.;
AU - Cooper, J. F.;
AU - Seligmann, E. B., Jr.;
AU - Wolff, S. M.;
T1 - Further developments of limulus amebocyte lysate test
CT - Further developments of limulus amebocyte lysate test
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1973/05/01/
VL - 27
IS - May-Jun
SP - 139
EP - 148
AD - Bureau of Biologics, FDA, National Institute of Allergy and Infectious Diseases, NIH, Bureau of Radiological Health, FDA, Bethesda, Maryland
N1 - Accession Number: 11-0683; Language: English; References: 10; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - A discussion of methods used for lysing the blood cells of the horseshoe crab, Limulus polyphemus, and the quality of lysate obtained for use in pyrogen testing, is presented. Amebocyte lysates were prepared from approximately one thousand sexually immature and mature horseshoe crabs, \IT/Limulus polyphemus\OK/. Cell suspending media are discussed along with osmotic pressure, vortex mixing, glass tissue homogenizer, lyophilization, and sonification as methods for amebocyte lysis.
KW - Tests--pyrogens--Limulus amebocyte lysate, methods of preparation;
KW - Pyrogens--tests--Limulus amebocyte lysate, methods of preparation;
KW - Lyophilization--lysate--Limulus amebocyte, preparation, for pyrogen testing, in vitro;
KW - Limulus polyphemus--amebocyte lysate--preparation, methods, for pyrogen testing, in vitro;
KW - Methodology--Limulus polyphemus--amebocyte lysate, preparation, for in vitro pyrogen testing;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - Walker, M. D.;
AU - Canellos, G. P.;
AU - Schein, P. S.;
AU - Chabner, B. A.;
AU - \ET/;
T1 - Initial clinical trials with methyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (M\LC/e\UC/CCNU)
CT - Initial clinical trials with methyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (M\LC/e\UC/CCNU)
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1973/05/01/
VL - 31
IS - May
SP - 1164
EP - 1169
AD - Building 10, Room 12N226, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-2419; Language: English; Trade Name: MeCCNU; Generic Name: Lomustine; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents lomustine; References: 11; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - An evaluation of methyl CCNU (methyl lomustine; I) in 50 patients with various carcinomas is presented. Preliminary clinical trials indicate that I is well tolerated and biologically active when given orally. Ten of the 50 patients in the study had objective therapeutic responses to I. Responses were seen in patients with melanoma, primary brain tumors, Hodgkin's disease, lymphosarcoma, and reticulum cell sarcoma. The primary toxicity of this agent is delayed myelosuppression, which appears 3 to 5 weeks after a single oral dose and is usually manifest as thrombocytopenia. No significant renal or hepatic side effects have been observed. Some evidence for cumulative marrow toxicity was noted in 42% of the patients receiving multiple doses. In previously treated patients there is usually consistent, but tolerable, marrow suppression at a dose of 200 mg./sq.m. although extent of prior therapy will necessitate individualizing the dose in many instances.
KW - Lomustine--methyl-;
KW - Antineoplastic agents--lomustine--methyl, carcinoma therapy, and toxicity, in patients;
KW - Toxicity--lomustine--methyl, in cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Boylston, A.W.
T1 - Theta Antigen and Immunoglobulin on a Tissue-cultured Mouse Lymphoma.
JO - Immunology
JF - Immunology
Y1 - 1973/05//
VL - 24
IS - 5
M3 - Article
SP - 851
EP - 857
PB - Wiley-Blackwell
SN - 00192805
AB - E1-4, a tissue culture established murine lymphoma, is shown to carry the θ-antigen and to have immunoglobulin in its membrane. Both are present in quantities similar to those found on normal C57 B1/6N thymocytes. This cell line may prove a useful model for the study of T cell membranes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - LYMPHOMAS
KW - IMMUNOGLOBULINS
KW - T cells
KW - CELL lines
KW - BIOLOGICAL membranes
N1 - Accession Number: 13384989; Boylston, A.W. 1; Affiliation: 1: Hematology Laboratory, Department of Clinical Pathology, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: May73, Vol. 24 Issue 5, p851; Subject Term: ANTIGENS; Subject Term: LYMPHOMAS; Subject Term: IMMUNOGLOBULINS; Subject Term: T cells; Subject Term: CELL lines; Subject Term: BIOLOGICAL membranes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Kirkpatrick, C. H.;
AU - Meek, J. C.;
AU - Rich, R. R.;
T1 - Mechanism of allergy to components of commercial bovine thyrotropin
CT - Mechanism of allergy to components of commercial bovine thyrotropin
JO - J. Allergy Clin. Immunol.
JF - J. Allergy Clin. Immunol.
Y1 - 1973/05/01/
VL - 51
IS - May
SP - 296
EP - 302
AD - Building 10, Room 11B-13 National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4467; Language: English; Trade Name: TSH; Generic Name: Thyrotropin; Chemical Name: Thyrotropin--9002-71-5 Thyroid--8028-36-2; References: 20; Journal Coden: JACIBY; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Ronald E. Nagata, Jr.
N2 - A 24-year-old woman with hypothyroidism and chronic mucocutaneous candidiasis developed a systemic immediate-type allergic reaction to bovine thyrotropin (TSH) injection. Precipitating antibodies against bovine serum albumin and gamma globulin were present in the patient's serum. Skin testing with bovine TSH and BSA provoked wheal-and-flare reactions.
KW - Thyrotropin--adverse reactions-;
KW - Thyroid--thyrotropin-;
KW - Drugs, adverse reactions--thyrotropin--allergies, systemic, in hypothyroid patient;
KW - Sensitivity--thyrotropin--allergies, systemic, in hypothyroid patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hurst, K. S.;
AU - Byar, D. P.;
T1 - Analysis of the effects of changes from the assigned treatment in a clinical trial of treatment for prostatic cancer
CT - Analysis of the effects of changes from the assigned treatment in a clinical trial of treatment for prostatic cancer
JO - J. Chronic Dis.
JF - J. Chronic Dis.
Y1 - 1973/05/01/
VL - 26
IS - May
SP - 311
EP - 324
AD - VA Cooperative Urological Research Group, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, N1H, Landow Building Room C-519, Bethesda, Maryland 20014
N1 - Accession Number: 11-1670; Language: English; References: 11; Journal Coden: JOCDAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The clinical course of patients originally part of a large scale randomized prospective clinical trial of treatment for cancer of the prostate who were later taken off study and given additional therapy is described. The following observations were made: Patients whose initial treatment was placebo were more likely to be taken off study, were taken off study when they were in comparatively better health than patients on the other treatments, and survived longer after going off study. Patients whose original treatment was placebo were more likely to benefit from secondary treatment. There was no evidence in these data that the treatment with estrogen in the late stages of cancer of the prostate was associated with increased risk of death due to cardiovascular causes. A decrease in the acid phosphatase could occur late in the course of the disease if therapy was changed even if the initial therapy included estrogen or orchiectomy or both. The results of this analysis are consistent with the philosophy that hormonal treatment or orchiectomy for cancer of the prostate should be witheld until it is required for relief of symptoms.
KW - Estrogens--carcinomas--prostatic, rational therapy, in patients;
KW - Antineoplastic agents--estrogens--carcinomas, prostatic, rational therapy, in patients;
KW - Rational therapy--estrogens--carcinomas, prostatic, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2005-10589-012
AN - 2005-10589-012
AU - Torres, Lorraine B.
T1 - The Participants in Social Science Research.
JF - Professional Psychology
JO - Professional Psychology
JA - Prof Psychol
Y1 - 1973/05//
VL - 4
IS - 2
SP - 211
EP - 216
CY - US
PB - American Psychological Association
SN - 0033-0175
N1 - Accession Number: 2005-10589-012. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Torres, Lorraine B.; Social Sciences Section, Behavioral Sciences Research Branch, National Institute of Mental Health, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Social Sciences. Minor Descriptor: Government Agencies. Classification: Research Methods & Experimental Design (2260); Professional Psychological & Health Personnel Issues (3400). Page Count: 6. Issue Publication Date: May, 1973. Copyright Statement: American Psychological Association. 1973.
AB - Comments about the relationships between those who 'produce' and those who 'use' research. The author discusses the National Institute for Mental Health's programs and defines the relationships of the producers and the users of research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social science research
KW - producers & users of research
KW - National Institute for Mental Health
KW - programs
KW - 1973
KW - Experimentation
KW - Social Sciences
KW - Government Agencies
KW - 1973
DO - 10.1037/h0020901
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - HENDERSON JR, U. V.
AU - STEIN, BERNARD R.
AU - STETTEN JR, DEWITT
T1 - Research Planning.
JO - Science
JF - Science
Y1 - 1973/05/04/
VL - 180
IS - 4085
M3 - Article
SP - 448
EP - 448
SN - 00368075
N1 - Accession Number: 85117116; HENDERSON JR, U. V.; STEIN, BERNARD R.; STETTEN JR, DEWITT 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 5/ 4/1973, Vol. 180 Issue 4085, p448; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Schein, P. S.;
T1 - Use of drugs in combination for the treatment of cancer
CT - Use of drugs in combination for the treatment of cancer
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1973/05/10/
VL - 288
IS - May 10
SP - 998
EP - 006
SN - 00284793
AD - Building 10, 12N226, National Cancer Institute, Bethesda, Maryland 10014
N1 - Accession Number: 10-4278; Language: English; References: 75; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2 - A review is presented on the use of drugs in combination for the treatment of cancer; and clinical studies employing drug combinations are discussed. It was stated that combination therapy has been employed in the treatment of cancer because satisfactory results are usually not obtained using single treatment.
KW - Combined therapy--antineoplastic agents--effects, review, in patients;
KW - Antineoplastic agents--combined therapy--effects, review, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ROWE, WALLACE P.
AU - SATO, HIDETOSHI
T1 - Genetic Mapping of the Fv-1 Locus of the Mouse.
JO - Science
JF - Science
Y1 - 1973/05/11/
VL - 180
IS - 4086
M3 - Article
SP - 640
EP - 641
SN - 00368075
AB - The Fv-l locus of the mouse, a major determinant of the biology of murine leukemia virus, is very closely linked to Gpd-I on chromosome 4 (linkage group VIII). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436881; ROWE, WALLACE P. 1; SATO, HIDETOSHI 2; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Division of Immunology, Sloan Kettering Institute for Cancer Research, New York 10021; Issue Info: 5/11/1973, Vol. 180 Issue 4086, p640; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARON, SAMUEL
AU - FINTER, NORMAN B.
AU - GALASSO, GEORGE J.
AU - GLASGOW, LOWELL A.
AU - LEVY, HILTON B.
AU - YOUNGER, JULIUS S.
T1 - Interferon.
JO - Science
JF - Science
Y1 - 1973/05/18/
VL - 180
IS - 4087
M3 - Article
SP - 779
EP - 784
SN - 00368075
N1 - Accession Number: 85117196; BARON, SAMUEL 1; FINTER, NORMAN B. 1; GALASSO, GEORGE J. 1; GLASGOW, LOWELL A. 1; LEVY, HILTON B. 1; YOUNGER, JULIUS S. 1; Affiliations: 1: Antiviral Substances Program, Infectious Disease Branch, Collaborative Research Program, National Institute of Allergy and Infectious Diseases, Building 31, Bethesda, Maryland 20014; Issue Info: 5/18/1973, Vol. 180 Issue 4087, p779; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STEPHENSON, JOHN R.
AU - AARONSON, STUART A.
T1 - Segregation of Loci for C-Type Virus Induction in Strains of Mice with High and Low Incidence of Leukemia.
JO - Science
JF - Science
Y1 - 1973/05/25/
VL - 180
IS - 4088
M3 - Article
SP - 865
EP - 866
SN - 00368075
AB - Multiple genetic loci for induction of murine leukemia viruses are demonstrated in cells of the high leukemic incidence C58 mouse strain. The biologic properties of viruses at C58 inducibility loci are clearly distinguishable from those of viruses activated from mouse cells containing a locus for virus induction of the low leukemia incidence BALB/c strain. These findings are consistent with the hypothesis that the genes for virus induction in normal mouse embryo cells represent viral structural information. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158560; STEPHENSON, JOHN R. 1; AARONSON, STUART A. 1; Affiliations: 1: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/25/1973, Vol. 180 Issue 4088, p865; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - DeFronzo, R. A.;
AU - Braine, H.;
AU - Colvin, O. M.;
AU - Davis, P. J.;
T1 - Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation
CT - Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/06/01/
VL - 78
IS - Jun
SP - 861
EP - 869
SN - 00034819
AD - Metabolism Section, Clinical Physiology Branch, Gerontology Research Center, National Institute of Child Health and Human Development, NIH, Bethesda; and Department of Medicine and Division of Oncology, Johns Hopkins University and Baltimore City Hospitals, Baltimore, Maryland
N1 - Accession Number: 10-4675; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 20; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Judith A. Kepler
N2 - Cyclophosphamide I. V. therapy in doses greater than 50 mg./kg. has resulted in frank impairment of water excretion in 17 of 19 normally hydrated patients with cancer. Clinically, these patients developed hyponatremia,weight gain, and inappropriately concentrated urine during cyclophosphamide infusion. These findings relate to the in vivo conversion of cyclophosphamide to its active alkylating metabolites. The syndrome is reversible after withdrawal of the drug.
KW - Cyclophosphamide--toxicity-;
KW - Toxicity--cyclophosphamide--water intoxication, in patients;
KW - Antineoplastic agents--cyclophosphamide--water intoxication, in patients;
KW - Dosage--cyclophosphamide--water intoxication, in patients;
KW - Metabolism--cyclophosphamide--and water intoxication due to metabolites, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
AU - Jasinski, D. R.;
AU - Mansky, P. A.;
T1 - Naltrexone, an antagonist for the treatment of heroin dependence
CT - Naltrexone, an antagonist for the treatment of heroin dependence
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/06/01/
VL - 28
IS - Jun
SP - 784
EP - 791
AD - National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky 40507
N1 - Accession Number: 11-0747; Language: English; Trade Name: EN-1639A--Narcan; Generic Name: Naltrexone; Naloxone; Chemical Name: Naltrexone--16590-41-3; References: 18; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Ronald E. Nagata, Jr.
N2 - A series of studies to determine the pharmacologic potency of naltrexone (EN-1639A), a narcotic antagonist, were performed on 13 patients. Naltrexone antagonism is 17 times more potent than nalorphine; the drug is longer acting than naloxone (Narcan), but shorter than cyclazocine. A comparable degree of heroin or morphine blockade was achieved by daily doses of 50 mg. of naltrexone and 4 mg. of cyclazocine. As an orally effective agent, naltrexone is virtually devoid of agonistic activity, and nalorphine-like dysphoric effects.
KW - Naltrexone--effects-;
KW - Narcotic antagonists--naltrexone--effects, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Decker, John L.
AU - Healey, L. A.
T1 - When to use cytotoxic drugs in rheumatoid arthritis.
JO - Geriatrics
JF - Geriatrics
Y1 - 1973/06//
VL - 28
IS - 6
M3 - Article
SP - 103
EP - 106
SN - 0016867X
N1 - Accession Number: 17729238; Decker, John L. 1; Healey, L. A. 2; Source Information: Jun1973, Vol. 28 Issue 6, p103; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2165
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Schlesselman, James J.
T1 - Data Transformation in Two-Way Analysis of Variance.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1973/06//
VL - 68
IS - 342
M3 - Article
SP - 369
SN - 01621459
AB - A procedure for choosing a power transformation so that data from a replicated two-way classification better satisfy the usual analysis of variance assumptions is described. The statistic proposed in this article is compared with the Box and Cox [7] likelihood procedure by empirical sampling. Its 95 percent confidence intervals performed at their nominal level, which was not true for the likelihood method. Point estimates for both techniques were the same on the average, although those based upon the likelihood statistic were somewhat less variable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of variance
KW - ESTIMATION theory
KW - SAMPLING (Statistics)
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - TRANSFORMATIONS (Mathematics)
KW - CONFIDENCE intervals
N1 - Accession Number: 4601870; Schlesselman, James J. 1; Affiliations: 1: Senior Staff Fellow, Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Md. 20014.; Issue Info: Jun73, Vol. 68 Issue 342, p369; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Subject Term: TRANSFORMATIONS (Mathematics); Subject Term: CONFIDENCE intervals; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - RAPOPORT, STANLEY I.
AU - THOMPSON, HARRY K.
T1 - Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits.
JO - Science
JF - Science
Y1 - 1973/06//6/ 1/1973
VL - 180
IS - 4089
M3 - Article
SP - 971
EP - 971
SN - 00368075
AB - Hypertonic urea or lactamide solutions osmotically open the bloodbrain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178657; RAPOPORT, STANLEY I. 1; THOMPSON, HARRY K. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/ 1/1973, Vol. 180 Issue 4089, p971; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAAPALA, DANIEL K.
AU - FISCHINGER, PETER J.
T1 - Molecular Relatedness of Mammalian RNA Tumor Viruses as Determined by DNA. RNA Hybridization.
JO - Science
JF - Science
Y1 - 1973/06//6/ 1/1973
VL - 180
IS - 4089
M3 - Article
SP - 972
EP - 974
SN - 00368075
AB - Each of six mammalian C-type viruses-including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114-can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA - RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178658; HAAPALA, DANIEL K. 1; FISCHINGER, PETER J. 1; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 1/1973, Vol. 180 Issue 4089, p972; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Fermaglich, J.;
AU - Chase, T. N.;
T1 - Methyldopa or methyldopahydrazine as levodopa synergists
CT - Methyldopa or methyldopahydrazine as levodopa synergists
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/06/02/
VL - 1
IS - Jun 2
SP - 1261
EP - 1262
SN - 00237507
AD - Georgetown University Medical Center and National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4554; Language: English; Trade Name: Aldomet--MK-486; Generic Name: Methyldopa; Methyldopahydrazine; Chemical Name: Methyldopa--41372-08-1; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents methyldopa, comparison, methyldopahydrazine (12:08.04); AHFS Class: Antiparkinson agents methyldopahydrazine, comparison, methyldopa; References: 5; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions; Investigational Drugs; Abstract Author: Joan Lentine
N2 - The effects of methyldopa (Aldomet) and MK-486 (methyldopahydrazine) on the potentiation of levodopa were compared in 10 parkinsonian patients. Each patient received MK-486, methyldopa, and placebo, during which time the dose of levodopa was adjusted to maintain an optimum therapeutic response. MK-486 was introduced at a daily dose of 20 mg. and increased weekly to 160 mg. Methyldopa was begun at a dose of 80 mg./day and similarly increased to 1920 mg. Both methyldopa and MK-486 potentiated the ability of levodopa to reduce parkinsonian signs. Potentiation increased directly with increasing doses of methyldopa but tended to level off with MK-486 at daily doses above 80 mg.
KW - Methyldopa--comparison, methyldopahydrazine-;
KW - Methyldopahydrazine--comparison, methyldopa-;
KW - Antiparkinson agents--methyldopa, comparison, methyldopahydrazine--potentiation, levodopa, in parkinsonian patients;
KW - Antiparkinson agents--methyldopahydrazine, comparison, methyldopa--potentiation, levodopa, in parkinsonian patients;
KW - Drug interactions--levodopa and methyldopa, comparison, methyldopahydrazine--potentiation, levodopa, in parkinsonian patients;
KW - Drug interactions--methyldopahydrazine and levodopa--potentiation, levodopa, in parkinsonian patients;
KW - Drug interactions--methyldopa and levodopa--potentiation, levodopa, in parkinsonian patients;
KW - Drug interactions--levodopa and methyldopahydrazine, comparison, methyldopa--potentiation, levodopa, in parkinsonian patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BADER, JOHN P.
T1 - Virus-Induced Transformation without Cell Division.
JO - Science
JF - Science
Y1 - 1973/06/08/
VL - 180
IS - 4090
M3 - Article
SP - 1069
EP - 1071
SN - 00368075
AB - Interference with the cell cycle by vinblastine sulfate immediately after cells were infected with Rous sarcoma virus had little effect on the development of two metabolic changes that occur in transformed cells. These results, along with an earlier demonstration of morphological changes developing in infected nondividing cells, demonstrate that the phenotypic development of the malignant state can occur without the intervention of cell divisions after infection by Rous sarcoma virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178699; BADER, JOHN P. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/ 8/1973, Vol. 180 Issue 4090, p1069; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - Canellos, G. P.;
AU - Chabner, B. A.;
AU - Schein, P. S.;
AU - DeVita, V. T.;
T1 - Maintenance chemotherapy for advanced Hodgkin's disease in remission
CT - Maintenance chemotherapy for advanced Hodgkin's disease in remission
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/06/16/
VL - 1
IS - Jun 16
SP - 1339
EP - 1343
SN - 00237507
AD - National Cancer Institute, Building 10, Room 12N226, Bethesda, Maryland 20014
N1 - Accession Number: 10-4267; Language: English; Trade Name: Nitrogen mustard--Oncovin--BCNU--1,3-bis(2-Chloroethyl)-1-nitrosourea; Generic Name: Mechlorethamine; Vincristine; Carmustine; Carmustine; Chemical Name: Carmustine--154-93-8 Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine; References: 14; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Fifty-seven patients with advanced Hodgkin's disease who entered a complete remission after chemotherapy with mechlorethamine (nitrogen mustard), vincristine (Oncovin), procarbazine, and prednisone (MOPP) were allocated at random to one of 3 regimens\M/no additional therapy, intermittent therapy with MOPP or intermittent therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU: carmustine). 24% of those patients receiving no further therapy have relapsed, as have 25% of those on intermittent MOPP and 13% of those on intermittent BCNU; the differences are not significant. The median duration of initial remissions will be \GT/ 48 months for all the patients, and there is no significant difference between the individual groups. Complications and infections were more frequently seen in the patients receiving maintenance therapy, especially in those on BCNU. Only 1 patient in each of the 3 groups has died of Hodgkin's disease, and survival is not significantly influenced by maintenance therapy. The projected 5-year survival for the entire group of patients is 86%.
KW - Carmustine--Hodgkin's disease-;
KW - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW - Antineoplastic agents--combined therapy--maintenance, Hodgkin's disease, lack, effects, in patients;
KW - Combined therapy--antineoplastic agents--maintenance, Hodgkin's disease, lack, effects, in patients;
KW - Antineoplastic agents--carmustine--Hodgkin's disease, maintenance therapy, lack, effects, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Woods, A. C.;
AU - Glaubiger, G. A.;
AU - Chase, T. N.;
T1 - Sustained-release levodopa
CT - Sustained-release levodopa
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/06/16/
VL - 1
IS - Jun 16
SP - 1391
SN - 00237507
AD - Neurology Unit, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4083; Language: English; Trade Name: Brocadopa Temtabs; Generic Name: Levodopa; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents levodopa; References: 2; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Biopharmaceutics; Drug Evaluations; Abstract Author: Joan Lentine
N2 - Results of preliminary studies in 3 parkinsonian patients suggested that the irregular response to a sustained-release levodopa preparation (Brocadopa Temtabs) is due to the failure of this preparation to maintain clinically effective plasma dopa concentrations for significantly longer periods than the standard form of levodopa.
KW - Levodopa--sustained-action-;
KW - Sustained-action medications--levodopa--effects, irregular, ineffective blood levels, in parkinsonian patients;
KW - Antiparkinson agents--levodopa--sustained-action, irregular effects, ineffective blood levels, in parkinsonian patients;
KW - Blood levels--levodopa--sustained-action, ineffective, in parkinsonian patients;
KW - Metabolism--levodopa--blood levels, ineffective, sustained-action, in parkinsonian patients;
KW - Formulations--levodopa--sustained-action, effects, irregular, ineffective blood levels, in patients;
KW - Drugs, availability--levodopa--sustained-action, irregular effects, ineffective blood levels, in parkinsonian patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Broder, L. E.;
AU - Carter, S. K.;
T1 - Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients
CT - Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/07/01/
VL - 79
IS - Jul
SP - 108
EP - 118
SN - 00034819
AD - Cancer Therapy Evaluation Branch, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland
N1 - Accession Number: 11-4411; Language: English; Trade Name: NSC-85998; Generic Name: Streptozotocin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 43; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Clinical experience with streptozotocin (NSC-85998) in 52 patients with metastatic islet cell carcinoma is discussed. The drug was given I.V. in 44 patients and intra-arterially in 8 patients, most often on a weekly schedule of 0.6 to 1.0 g./sq. m. Biochemical responses were seen in 64% of evaluable cases, and measurable disease responses were seen in 50% of these cases. Insulin responses occurred 2 to 3 weeks after drug administration at a total dose of about 2 to 4 g./sq. m. A significant increase in 1-year survival rate and a doubling of median survival were shown for the responders as compared with the nonresponders. Acute toxicity, consisting of nausea and vomiting, was observed in 98% of the cases, whereas renal or hepatic toxicity was seen in 65% and 67% of the cases, respectively. Hematological toxicity, observed in 20% of the cases, was mild. Renal and hepatic toxicity were usually reversible, but 5 patients died in renal failure.
KW - Streptozotocin--carcinomas-;
KW - Antineoplastic agents--streptozotocin--carcinomas, metastatic islet cell, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Aptekar, R. G.;
AU - Atkinson, J. P.;
AU - Decker, J. L.;
AU - Wolff, S. M.;
AU - Chu, E. W.;
T1 - Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant disease
CT - Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant disease
JO - Arthritis and Rheumatism (USA)
JF - Arthritis and Rheumatism (USA)
Y1 - 1973/07/01/
VL - 16
IS - Jul-Aug
SP - 461
EP - 467
SN - 00043591
AD - National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, The National Cancer Institute Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-0997; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 22; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Jack Rosenberg
N2 - A discussion of bladder toxicity in 46 patients, resulting from chronic oral cyclophosphamide therapy in nonmalignant disease, is presented. Over 600 months of oral cyclophosphamide therapy was given to patients with systemic lupus erythematosis (SLE), Wegener's granulomatosis, rheumatoid arthritis, idiopathic nephrotic syndrome, and hypereosinophilic syndrome. If an abnormal urinalysis was noted, urine cytology was done on a double-voided specimen. Thirteen (28%) had urinary bladder complications. Three distinct problems were apparent: chronic cystitis in 6, abnormal urine cytology in 3, acute hemorrhagic cystitis in 4. These patterns could not have been segregated without urine cytology. Persistence of abnormal findings may lead to irreversible bladder toxicity.
KW - Cyclophosphamide--toxicity-;
KW - Toxicity--cyclophosphamide--bladder, in nonmalignant disease therapy, in patients;
KW - Antineoplastic agents--cyclophosphamide--toxicity, bladder, nonmalignant disease therapy, in patients;
KW - Drugs, adverse reactions--cyclophosphamide--bladder, complications, nonmalignant disease therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gillette, J. R.;
AU - Menard, R. H.;
AU - Stripp, B.;
T1 - Active products of fetal drug metabolism
CT - Active products of fetal drug metabolism
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1973/07/01/
VL - 14
IS - Jul-Aug
SP - 680
EP - 692
SN - 00099236
AD - Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 11-2772; Language: English; References: 41; Journal Coden: CLPTAT; Section Heading: Drug Metabolism and Body Distribution
N2 - Theoretical relationships between the activities of placental and fetal enzymes and their ability to perturb the steady-state tissue levels of drugs have been calculated. Although the calculations suggest that the activities of the enzymes that metabolize desipramine and 3,4-benzpyrene in human placentas and fetuses may be high enough to decrease the steady-state concentrations of these substances, the rates of metabolism of most drugs are probably too slow to affect the fetal levels of most lipid-soluble compounds. It is also probable that the rate of bromobenzene metabolism by cytochrome P-450 enzymes in fetal liver is too slow to cause liver necrosis caused by this toxicant. Nevertheless, it is possible that enzymes that catalyze the reduction of nitro compounds, such as nitrofurazone, to hydroxylamino derivatives may mediate various drug toxicities in fetuses.
KW - Metabolism--drugs--fetal, discussion;
KW - Placental transfer--drugs--metabolism, fetal, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Nebert, D. W.;
T1 - Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal
CT - Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1973/07/01/
VL - 14
IS - Jul-Aug
SP - 693
EP - 699
SN - 00099236
AD - Section on Developmental Pharmacology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland
N1 - Accession Number: 11-2798; Language: English; References: 44; Journal Coden: CLPTAT; Section Heading: Methodology; Abstract Author: Monte S. Cohon
N2 - It is postulated that teratogenicity of various drugs in a certain strain or species of animal may be predicted if one is able to quantitate certain parameters of a compound's metabolism in fetal cell cultures from that particular strain or species.
KW - Teratogenicity--drugs--prediction, in fetal cell cultures, in animal strains;
KW - Toxicity--drugs--prediction, in fetal cell cultures, in animal strains;
KW - Metabolism--drugs--teratogenicity, prediction, in fetal cell cultures, in animal strains;
KW - Methodology--teratogenicity--drugs, prediction, in fetal cell cultures, in animal strains;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Werblin, T. P.
AU - Kim, Y. T.
AU - Mage, Rose
AU - Benacerraf, B.
AU - Siskind, G. W.
T1 - The Generation of Antibody Diversity I. STUDIES ON THE POPULATION DISTRIBUTION OF ANTI-DNP ANTIBODY AFFINITIES AND ON THE INFLUENCE OF ALLOTYPE ON ANTIBODY AFFINITY AND CONCENTRATION.
JO - Immunology
JF - Immunology
Y1 - 1973/07//
VL - 25
IS - 1
M3 - Article
SP - 17
EP - 32
PB - Wiley-Blackwell
SN - 00192805
AB - A genetically diverse population of sixty-four rabbits has been studied with respect to the concentration and affinity of anti-DNP antibody produced over the course of a year following a single injection of DNP-BGG. It was found that the responses of male and female members of the population were essentially identical throughout the entire course of the immune response. The effect of allotype on the concentration and affinity of the antibody produced was examined. It was observed that the b6 allotype was associated with the production of decreased concentrations of antibody, the b5 allotype with the production of increased concentrations of antibody, the a1 allotype with the production of high affinity antibody and the a2 allotype with the production of low affinity antibody when compared to the remainder of the population. A tendency was also seen for individuals to maintain, over the course of time, their relative position in the population with respect to the concentration and affinity of the antibody they produce. Finally, it was observed that the mean affinity of the population continually shifted towards high affinity over the period of observation and that the standard deviation of the population with regard to the affinity of the antibody produced decreased with time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBODY diversity
KW - IMMUNOGLOBULIN allotypes
KW - IMMUNOGLOBULINS
KW - IMMUNE response
KW - IMMUNOLOGY
KW - IMMUNOGENETICS
N1 - Accession Number: 13437927; Werblin, T. P. 1 Kim, Y. T. 1 Mage, Rose 1 Benacerraf, B. 1 Siskind, G. W. 1; Affiliation: 1: Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York 10021, Department of Pathology, New York University School of Medicine, New York, 10016; Laboratory of Immunology, National Institute of Allergy of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20014, and Department of Pathology, Harvard Medical School, Boston, U.S.A.; Source Info: Jul73, Vol. 25 Issue 1, p17; Subject Term: ANTIBODY diversity; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: IMMUNOGENETICS; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, Edward F.
AU - Murphy, Dennis L.
T1 - PRIMARY AFFECTIVE DISORDER: MMPI DIFFERENCES BETWEEN UNIPOLAR AND BIPOLAR DEPRESSED SUBJECTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1973/07//
VL - 29
IS - 3
M3 - Article
SP - 303
EP - 306
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article presents a study, which focuses on the primary affective disorder. This study also compares unipolar and bipolar Ss hospitalized for depression with the MMPI. In addition, behavioral ratings for these two groups were obtained simultaneously on the Bunney-Hamburg depression scale and compared with the MMPI results. The results of the study indicate that groups of unipolar and bipolar Ss have significantly different scores on the MMPI during depressive episodes, further evidence is provided in support of the role of mania in delineating a subgroup of Ss with primary affective disorder who also demonstrate distinctive clinical, familial and biological features.
KW - AFFECTIVE disorders
KW - PATHOLOGICAL psychology
KW - PSYCHOSES
KW - MENTALLY ill
KW - HUMAN behavior
KW - RESEARCH
N1 - Accession Number: 15903694; Donnelly, Edward F. 1 Murphy, Dennis L. 1; Affiliation: 1: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jul1973, Vol. 29 Issue 3, p303; Subject Term: AFFECTIVE disorders; Subject Term: PATHOLOGICAL psychology; Subject Term: PSYCHOSES; Subject Term: MENTALLY ill; Subject Term: HUMAN behavior; Subject Term: RESEARCH; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Chess, L.;
AU - Bock, G. N.;
AU - Ungaro, P. C.;
AU - Buchholz, D. H.;
AU - Mardiney, M. R., Jr.;
T1 - Immunologic effects of BCG in patients with malignant melanoma: specific evidence for stimulation of the secondary immune response
CT - Immunologic effects of BCG in patients with malignant melanoma: specific evidence for stimulation of the secondary immune response
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/07/01/
VL - 51
IS - Jul
SP - 57
EP - 65
SN - 00278874
AD - Section of Immunology and Cell Biology, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland 21211
N1 - Accession Number: 11-2055; Language: English; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2 - The effects of BCG vaccine on immunologic function were assessed in 4 patients with malignant melanoma. Cell-associated immune function was quantitatively measured in vitro by the incorporation of H-thymidine into frozen-stored lymphocytes in response to specific antigens (both related and unrelated to BCG), allogeneic lymphocytes, and phytohemagglutinin (PHA). In vivo, cell-mediated immunity was determined by delayed hypersensitivity skin reactions to various antigens. Serum IgG, IgM, IgA, and C\PR/3 (complement) levels were quantitated. BCG administration significantly augmented antigen-induced incorporation of H-thymidine in 3 patients, with little or no effect on responses to allogeneic lymphocytes or PHA. BCG selectively increased serum IgG levels in the same 3 patients. IgA, IgM, or complement levels were not enhanced. All patients converted their purified protein derivative (PPD) skin-test reactivity from negative to positive during therapy, and in 2 patients candida skin reactivity appeared. These effects on cell-associated immune functions, immunoglobulin, complement levels, and in vivo-delayed hypersensitivity were consistent with the hypothesis that BCG primarily augments host responsiveness to antigens to which the host has previously been exposed. No effects on the primary immune response was detected. The one patient who did not respond to BCG by cell-associated humoral immunologic enhancement had metastatic disease before initiation of study, which then rapidly progressed. Clinically, 2 of the 3 patients reacting immunologically, in addition to the one patient who failed to respond, developed progressive metastatic disease during therapy. One patient continues to respond immunologically and remains free of progressive disease.
KW - BCG vaccines--melanomas-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Heston, W. E.;
AU - Valahakis, G.;
AU - Desmukes, B.;
T1 - Effects of the antifertility drug Enovid in five strains of mice, with particular regard to carcinogenesis
CT - Effects of the antifertility drug Enovid in five strains of mice, with particular regard to carcinogenesis
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/07/01/
VL - 51
IS - Jul
SP - 209
EP - 222
SN - 00278874
AD - Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-1009; Language: English; Trade Name: Enovid; Generic Name: Mestranol; Chemical Name: Norethynodrel--68-23-5 Mestranol--72-33-3; Therapeutic Class: (68:12); AHFS Class: Contraceptives, oral norethynodrel, combination, mestranol (68:12); AHFS Class: Contraceptives, oral mestranol, combination, norethynodrel; Section Heading: Toxicity
N2 - The antifertility drug, Enovid (norethynodrel, combination, mestranol) was tested for possible carcinogenicity in female mice of 5 specially selected strains. The drug was fed at 3 dose levels: 5 mcg. Enovid/g. of food that did not prevent reproduction, 10 mcg./g. that prevented some females from reproducing, 20 mcg./g. that prevented all females from reproducing. The results emphasized that inbred strains of mice differed in their response to Enovid. Treatment reduced the gain in weight of all strains. It had no effect on life span in one strain, but in 2 strains life span was lengthened and in 2 shortened because of the effect on tumors or other lesions. Cervical and vaginal lesions showing invasion of the epithelium into the stroma with varying degrees of progression were observed but limited essentially to one strain. Highest incidence in progression occurred in the group treated with the highest dose of Enovid. None were observed as tumors and none had extended beyond the vaginal wall or showed any evidence of having metastasized. Occurrence of ovarian tumors did not increase at these dosage levels and mammary tumors seemed to be inhibited in the treated groups. Hepatomas seemed to be inhibited, probably due to growth effects, and in another strain there was some inhibition of adrenocortical adenomas.
KW - Norethynodrel--combination, mestranol-;
KW - Mestranol--combination, norethynodrel-;
KW - Contraceptives, oral--norethynodrel, combination, mestranol--effects, weight, life span, and carcinogenicity, in mice;
KW - Contraceptives, oral--mestranol, combination, norethynodrel--effects, weight, life span, and carcinogenicity, in mice;
KW - Toxicity--norethynodrel, combination, mestranol--studies, carcinogenicity, in mice;
KW - Toxicity--mestranol, combination, norethynodrel--studies, carcinogenicity, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Leeds, A. A.;
T1 - International reference center for information on psychotropic drugs: activities, plans, and news briefs
CT - International reference center for information on psychotropic drugs: activities, plans, and news briefs
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1973/07/01/
VL - 9
IS - Jul
SP - 1
EP - 0
AD - International Reference Center for Information on Psychotropic Drugs, Psychopharmacology Research Branch, National Institute of Mental Health, Parklawn Building, Room 9-105, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 11-0383; Language: English; Journal Coden: PSYBB9; Section Heading: Information Processing and Literature; Abstract Author: Douglas L. Thompson
N2 - The activities of the WHO Information Network relating to information on psychotropic drugs over the past 5 years are reviewed. The main purpose of this network is to direct inquiries from researchers to persons or institutions where specific information relating to these drugs may be obtained. A list of countries having collaborative or national reference centers on psychopharmacology is included. A classification of psychotropic drugs used by the international reference center network is included. Also included is a form for recording information relating to these drugs.
KW - Drug information--psychotherapeutic agents--International Reference Center;
KW - International Reference Center--psychotherapeutic agents--discussion;
KW - Psychotherapeutic agents--International Reference Center--discussion;
KW - Nomenclature--psychotherapeutic agents--used by International Reference Center;
KW - Forms--drug information--psychotherapeutic agents, used by International Reference Center;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - McGlashan, T. H.;
AU - Guy, W. H.;
AU - Davis, D.;
AU - Levine, J.;
T1 - Research plan report: revised form and information retrieval system
CT - Research plan report: revised form and information retrieval system
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1973/07/01/
VL - 9
IS - Jul
SP - 53
EP - 72
AD - Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
N1 - Accession Number: 11-0384; Language: English; Journal Coden: PSYBB9; Section Heading: Information Processing and Literature; Abstract Author: Douglas L. Thompson
N2 - The Research Plan Report concept, which is in essence a form for documenting the protocol for psychotropic drug trials, is discussed. The second revision of the original research plan report is described. A copy of the forms used in this report is included.
KW - Drug information--psychotherapeutic agents--discussion, Research Plan Report concept;
KW - Psychotherapeutic agents--drug information--discussion, Research Plan Report concept;
KW - Forms--drug information--psychotherapeutic agents, Research Plan Report concept;
KW - Research--psychotherapeutic agents--Research Plan Report concept, discussion;
KW - Methodology--drug information--psychotherapeutic agents, Research Plan Report concept;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schechter, Gail
AU - Buchsbaum, Monte
T1 - The Effects of Attention, Stimulus Intensity, and Individual Differences on the Average Evoked Response.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1973/07//
VL - 10
IS - 4
M3 - Article
SP - 392
EP - 400
SN - 00485772
AB - The effects of shifting attention toward or away from visual or auditory stimuli of varying intensities were studied using average evoked responses (AERs) in 24 normal human volunteers. Ss were asked to attend to visual or auditory stimuli of four intensities (randomly presented) or to ignore the lights and tones and do mental arithmetic. For visual stimuli, attentional effects were largest at low intensities whereas for auditory stimuli equal effects were shown across intensities. Similar individual rates of increase of AER amplitude with increasing intensity were observed for both visual and auditory stimuli when attentional conditions were controlled. These results suggest that some general intensity processing response is reflected in the AER and that it is important to control attention in AER experiments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STIMULUS intensity
KW - PERCEPTION
KW - EVOKED response audiometry
KW - INDIVIDUAL differences
KW - INTEREST (Psychology)
KW - ATTENTION
KW - Attention
KW - Average evoked response
KW - Individual differences.
KW - Stimulus intensity
N1 - Accession Number: 11083143; Schechter, Gail 1 Buchsbaum, Monte 1; Affiliation: 1: Unit of Psychophysiology, Laboratory of Psychology, National Institute of Mental Health, Bethesda.; Source Info: Jul1973, Vol. 10 Issue 4, p392; Subject Term: STIMULUS intensity; Subject Term: PERCEPTION; Subject Term: EVOKED response audiometry; Subject Term: INDIVIDUAL differences; Subject Term: INTEREST (Psychology); Subject Term: ATTENTION; Author-Supplied Keyword: Attention; Author-Supplied Keyword: Average evoked response; Author-Supplied Keyword: Individual differences.; Author-Supplied Keyword: Stimulus intensity; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-8986.ep11083143
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldschmidt, Walter
T1 - The Brideprice of the Sebei.
JO - Scientific American
JF - Scientific American
Y1 - 1973/07//
VL - 229
IS - 1
M3 - Article
SP - 74
EP - 85
SN - 00368733
AB - Presents the findings of a study on the brideprice contracts of Sebei in Uganda. Purpose of the brideprice payment being given by a man to the family of his bride; Principal spokesman of the bride in contract negotiations; Specific items involved in a brideprice contract.
KW - Bride price
KW - Sapiny (African people)
KW - Dowry
KW - Marriage brokerage
KW - Uganda
N1 - Accession Number: 21149867; Goldschmidt, Walter 1,2; Affiliations: 1: Professor, Anthropology and Psychiatry, University of California, Los Angeles; 2: Senior Science Fellow, National Institute of Mental Health; Issue Info: Jul1973, Vol. 229 Issue 1, p74; Subject Term: Bride price; Subject Term: Sapiny (African people); Subject Term: Dowry; Subject Term: Marriage brokerage; Subject: Uganda; Number of Pages: 12p; Illustrations: 8 Graphs, 2 Maps; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Evarts, Edward V.
T1 - BRAIN MECHANISMS IN MOVEMENT.
JO - Scientific American
JF - Scientific American
Y1 - 1973/07//
VL - 229
IS - 1
M3 - Article
SP - 96
EP - 103
SN - 00368733
AB - Focuses on the part of the brain that controls and integrates muscular movements. Implications of the discovery that muscular contraction could be produced by the electrical stimulation of a small region of the cerebral cortex; Difficulties faced by neurologists in studying volitional movement; Components of the brain that initiate motor response.
KW - Brain
KW - Motor ability
KW - Cerebral cortex
KW - Muscle contraction
KW - Human mechanics
N1 - Accession Number: 21149869; Evarts, Edward V. 1; Affiliations: 1: Member, Laboratory of Neurophysiology of the National Institute of Mental Health; Issue Info: Jul1973, Vol. 229 Issue 1, p96; Subject Term: Brain; Subject Term: Motor ability; Subject Term: Cerebral cortex; Subject Term: Muscle contraction; Subject Term: Human mechanics; Number of Pages: 8p; Illustrations: 10 Diagrams; Document Type: Article
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DB - eih
ER -
TY - JOUR
ID - 2013-41574-012
AN - 2013-41574-012
AU - Scrofani, Philip J.
AU - Suziedelis, Antanas
AU - Shore, Milton F.
T1 - Conceptual ability in Black and White children of different social classes: An experimental test of Jensen's hypothesis.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/07//
VL - 43
IS - 4
SP - 541
EP - 553
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-41574-012. PMID: 4716672 Partial author list: First Author & Affiliation: Scrofani, Philip J.; Catholic University of America, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Medical Society of Saint Elizabeth's Hospital, 34th. Conference Note: Portions were presented at the aforementioned conference. Major Descriptor: Childhood Development; Cognitive Ability; Concept Formation; Racial and Ethnic Differences; Social Class. Minor Descriptor: Blacks; Whites. Classification: Cognitive & Perceptual Development (2820). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Peabody Picture Vocabulary Test-Modified Version. Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: Jul, 1973.
AB - Jensen's theory of inherent conceptual ability differences between SES groups was tested by training children of all SES levels in concept formation. A significant number of low-SES children were able to achieve middle-class performance levels in conceptual tasks. The ability to profit from training was related to the developmental measures of cognition. No sex, age, or racial differences were found. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conceptual ability
KW - Black children
KW - White children
KW - social classes
KW - racial differences
KW - 1973
KW - Childhood Development
KW - Cognitive Ability
KW - Concept Formation
KW - Racial and Ethnic Differences
KW - Social Class
KW - Blacks
KW - Whites
KW - 1973
U1 - Sponsor: National Institute of Mental Health, Saint Elizabeth's Hospital, Division of Clinical ResfJarch and Training, US. Recipients: No recipient indicated
DO - 10.1111/j.1939-0025.1973.tb00823.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41574-033
AN - 2013-41574-033
AU - Dent, James K.
T1 - Review of Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition and The clinical interpretation of the Wechsler Adult Intelligence Scale.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/07//
VL - 43
IS - 4
SP - 685
EP - 686
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41574-033. Partial author list: First Author & Affiliation: Dent, James K.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Intelligence; Psychometrics; Test Construction; Wechsler Adult Intelligence Scale. Minor Descriptor: Cognitive Appraisal. Classification: Clinical Psychological Testing (2224); Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Matarazzo, Joseph D. Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition=Baltimore: Williams & Wilkins. 572 pp. $15.75; 1972. Lee Zimmerman, Ira; Woo-Sam, James; Glasser, Alan J. The clinical interpretation of the Wechsler Adult Intelligence Scale=New York: Grune & Stratton. 224 pp. $7.95; 1973. Page Count: 2. Issue Publication Date: Jul, 1973.
AB - Reviews the books, Wechsler's Measurement and Appraisal of Adult Intelligence: 5th & Enlarged Edition by Joseph D. Matarazzo (see record [rid]1973-26037-000[/rid]) and The Clinical Interpretation of the Wechsler Adult Intelligence Scale by Ira Lee Zimmerman, James Woo-Sam, and Alan J. Glasser (see record [rid]1973-28141-000[/rid]). In these two books it can he presumed that we have the independent selections of the authors, since Matarazzo is not mentioned in the index of Zimmerman and Woo-Sam and they are not mentioned in his. The results of these labors are two books quite different in their approaches and in their content. Clinicians using the WAIS will need to be familiar with both. Both books can be faulted for not telling us more about how they chose studies for inclusion. Neither of them attempts to assess future directions, either in the further development of the WAIS or in its uses in research and practice. But these faults do not really detract from their important and complementary accomplishments in bringing order to a large volume of empirical work. The reviewer suspects that both books' pages will be well-thumbed by clinicians until still newer integrations are available. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adult intelligence appraisal
KW - Wechsler Adult Intelligence Scale
KW - psychometrics
KW - test development
KW - clinical interpretation
KW - 1973
KW - Clinical Psychology
KW - Intelligence
KW - Psychometrics
KW - Test Construction
KW - Wechsler Adult Intelligence Scale
KW - Cognitive Appraisal
KW - 1973
U2 - Matarazzo, Joseph D. (1972); Wechsler's measurement and appraisal of adult intelligence: 5th & enlarged edition; Baltimore: Williams & Wilkins. 572 pp. $15.75
U2 - Lee Zimmerman, Ira; Woo-Sam, James; Glasser, Alan J. (1973); The clinical interpretation of the Wechsler Adult Intelligence Scale; New York: Grune & Stratton. 224 pp. $7.95
DO - 10.1037/h0097705
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Brady, R. O.;
AU - Tallman, J. F.;
AU - Johnson, W. G.;
AU - Gal, A. E.;
AU - Leahy, W. R.;
AU - \ET/;
T1 - Replacement therapy for inherited enzyme deficiency: use of purified ceramidetrihexosidase in Fabry's disease
CT - Replacement therapy for inherited enzyme deficiency: use of purified ceramidetrihexosidase in Fabry's disease
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1973/07/05/
VL - 289
IS - Jul 5
SP - 9
EP - 4
SN - 00284793
AD - Building 10, Room 3D-03, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 10-4051; Language: English; Therapeutic Class: (44:00); AHFS Class: Enzymes ceramidetrihexosidase; References: 30; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Ceramidetrihexosidase, which is lacking in patients with Fabry's disease, was highly purified from human placental tissue and administered I.V. to 2 patients with Fabry's disease. The patients tolerated the procedure very well. The enzyme was rapidly cleared from the blood and was taken up to a major extent by the liver. In one patient, the level of circulating ceramidetrihexoside decreased from 53 to 22 nmoles/10 ml. of plasma 40 min. after the enzyme was administered. In the other, who received 40% less enzyme, the level of circulating ceramidetrihexoside decreased from 67 to 45 nmoles/10 ml. of plasma. Infusions of normal fresh plasma or leukocytes and platelets suspended in plasma yielded results resembling the effect obtained with purified enzyme. Plasma infusion had no demonstrable effect.
KW - Ceramidetrihexosidase--Fabry's disease-;
KW - Enzymes--ceramidetrihexosidase--Fabry's disease, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - GUYTON, DAVID L.
AU - HAMBRECHT, F. TERRY
T1 - Capacitor Electrode Stimulates Nerve or Muscle without Oxidation-Reduction Reactions.
JO - Science
JF - Science
Y1 - 1973/07/06/
VL - 181
IS - 4094
M3 - Article
SP - 74
EP - 76
SN - 00368075
AB - Porous tantalum disks, available as "slugs" from the capacitor industry, have large available surface area and a thin insulating coating of tantalum pentoxide. When implanted, they fill with extracellular fluid and operate as capacitor-stimulating electrodes having high capacitance per unit volume. Capable of stimulating excitable tissue without generating electrochemical by-products, these electrodes should provide a safer interface between neural prosthetic devices and human tissue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158728; GUYTON, DAVID L. 1; HAMBRECHT, F. TERRY 1; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 6/1973, Vol. 181 Issue 4094, p74; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Douglass, Carl D.
AU - James, John C.
T1 - Support of New Principal Investigators by NIH: 1966 to 1972.
JO - Science
JF - Science
Y1 - 1973/07/20/
VL - 181
IS - 4096
M3 - Article
SP - 241
EP - 244
SN - 00368075
N1 - Accession Number: 85362867; Douglass, Carl D. 1; James, John C. 2; Affiliations: 1: Deputy director, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief, Research Analysis and Evaluation Branch, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p241; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LUST, W. DAVID
AU - PASSONNEAU, JANET V.
AU - VEECH, RICHARD L.
T1 - Cyclic Adenosine Monophosphate, Metabolites, and Phosphorylase in Neural Tissue: A Comparison of Methods of Fixation.
JO - Science
JF - Science
Y1 - 1973/07/20/
VL - 181
IS - 4096
M3 - Article
SP - 280
EP - 282
SN - 00368075
AB - Fixation of rat brain tissue by freeze-blowing, microwave irradiation, iimmersion of whole rats in liquid nitrogen, and decapitation into liquid nitrogen indicates that postmortem changes in metabolites and enzyme forms are minimal in freeze-blown brains. Cyclic adenosine monophosphate levels are lowest in microwave-irradiated brains, which has been interpreted by some investigators to indicate rapid fixation and minimal anoxia. However, the changes in phosphocreatine, adenosine triphosphate, lactate, and phosphorylase clearly demonstrate that fixation by freeze-blowing or immersion in liquid nitrogen more closely approximate the state in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85362894; LUST, W. DAVID 1; PASSONNEAU, JANET V. 1; VEECH, RICHARD L. 2; Affiliations: 1: National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p280; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - UPHOFF, DELTA E.
AU - WHITTINGHAM, D. G.
AU - LEIBO, S. P.
AU - MAZUR, PETER
T1 - Maternal Influences on Mouse Embryos and Preservation of Mutant Strains by Freezing.
JO - Science
JF - Science
Y1 - 1973/07/20/
VL - 181
IS - 4096
M3 - Article
SP - 287
EP - 288
SN - 00368075
N1 - Accession Number: 85362897; UPHOFF, DELTA E. 1; WHITTINGHAM, D. G. 2; LEIBO, S. P. 3; MAZUR, PETER 3; Affiliations: 1: Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Physiological Laboratory, Cambridge University, Cambridge, England; 3: Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p287; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Blye, R. P.;
T1 - Use of estrogens as postcoital contraceptive agents
CT - Use of estrogens as postcoital contraceptive agents
JO - American Journal of Obstetrics and Gynecology (USA)
JF - American Journal of Obstetrics and Gynecology (USA)
Y1 - 1973/08/01/
VL - 116
IS - Aug 1
SP - 1044
EP - 1050
SN - 00029378
AD - Contraceptive Development Branch, Center for Population Research, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-3968; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Therapeutic Class: (68:12); AHFS Class: Contraceptives postcoital diethylstilbestrol; References: 52; Journal Coden: AJOGAH; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Sufficient evidence has accrued to indicate that daily administration of 50 mg. of diethylstilbestrol, 30 mg. of conjugated equine estrogens or 5 mg. of ethinyl estradiol for 5 consecutive days is probably effective in preventing pregnancy if instituted within 72 hours of unprotected midcycle coital exposure.
KW - Diethylstilbestrol--contraceptives postcoital-;
KW - Estrogenic substances--conjugated--contraceptives postcoital, dosage schedules, in women;
KW - Ethinyl estradiol--contraceptives postcoital--dosage schedules, in women;
KW - Contraceptives postcoital--ethinyl estradiol--dosage schedules, in women;
KW - Contraceptives postcoital--diethylstilbestrol--dosage schedules, in women;
KW - Contraceptives postcoital--estrogenic substances--conjugated, dosage schedules, in women;
KW - Dosage schedules--diethylstilbestrol--contraceptives, postcoital, in women;
KW - Dosage schedules--estrogenic substances--conjugated, postcoital contraceptives, in women;
KW - Dosage schedules--ethinyl estradiol--contraceptives, postcoital, oral, in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Padilla, Elena
AU - Goldston, Steven E.
T1 - Exposure to Mental Health Training in Schools of Public Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/08//
VL - 63
IS - 8
M3 - Article
SP - 710
EP - 714
PB - American Public Health Association
SN - 00900036
AB - The article discusses the issue of mental health training in schools of public health. Mental health or mental hygiene has generally been included in the curricula of schools of public health. Two major purposes have guided the development of mental health training programs in schools of public health to broaden and improve the functional capacity of health manpower, and to provide mental health training sequences for students wishing to specialize in the mental health field. A total of 3,115 respondents replied to a questionnaire mailed in the summer of 1968 to 4,459 graduates from those schools, who were living or working throughout the U.S. and abroad. Contacts with psychiatrists ranked highest among respondents from nine schools. Over one-half of the contacts reported by respondents from Columbia, Illinois and Tulane, Louisiana were with psychiatrists. Roughly from one-third to two-thirds of the respondents were aware of having been exposed to mental health training while attending a school of public health.
KW - Public health
KW - Mental health
KW - Education
KW - Occupational training
KW - Psychiatrists
KW - United States
KW - Health (mental)
KW - Public health, schools
KW - schools
N1 - Accession Number: 7971035; Padilla, Elena 1; Goldston, Steven E. 2; Affiliations: 1: Consultant, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852.; 2: Coordinator for Primary Prevention Programs, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852.; Issue Info: Aug1973, Vol. 63 Issue 8, p710; Thesaurus Term: Public health; Subject Term: Mental health; Subject Term: Education; Subject Term: Occupational training; Subject Term: Psychiatrists; Subject: United States; Author-Supplied Keyword: Health (mental); Author-Supplied Keyword: Public health, schools; Author-Supplied Keyword: schools; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Sherins, R. J.;
AU - DeVita, V. T., Jr.;
T1 - Effect of drug treatment for lymphoma on male reproductive capacity
CT - Effect of drug treatment for lymphoma on male reproductive capacity
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/08/01/
VL - 79
IS - Aug
SP - 216
EP - 220
SN - 00034819
AD - Reproduction Research Branch, National Institute of Child Health and Human Development; and the Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-0024; Language: English; References: 27; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity
N2 - The effect of combined therapy with antineoplastic agents on spermatogenesis was studied in 16 patients. Reproductive function was evaluated in men who had been treated with (1) a combination of nitrogen mustard (mechlorethamine), vincristine, procarbazine, and prednisone; (2) a similar combination, with methotrexate instead of procarbazine; (3) cyclophosphamide, vincristine, and prednisone; or (4) cyclophosphamide for lymphoma, were in remission, and had received no therapy for 6 months to 7 years. Although libido and potency were normal in all patients, 10 men were azoospermic, and testicular biopsy showed complete absence of germ cells; 2 men showed minimal evidence of spermatogenesis; and 4 men, in remission for 2 to 7 years, showed complete spermatogenesis at the time of their evaluation. Within each treatment group the men with evidence of normal germinal tissue were those who had been in remission longest for that group. These data suggest that spermatogenesis may return after extensive chemotherapy but that this is more likely to occur more than 2 years after drug treatment.
KW - Antineoplastic agents--combined therapy--effects, male reproductive capacity, in patients;
KW - Combined therapy--antineoplastic agents--effects, male reproductive capacity, in patients;
KW - Toxicity--antineoplastic agents--studies, combined therapy, effects on male reproductive capacity, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - DeVita, V. T.;
AU - Johnson, R. E.;
T1 - Hodgkin's disease in childhood
CT - Hodgkin's disease in childhood
JO - Blood
JF - Blood
Y1 - 1973/08/01/
VL - 42
IS - Aug
SP - 163
EP - 174
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-3286; Language: English; Chemical Name: Mechlorethamine--51-75-2 Vincristine--57-22-7 Prednisone--53-03-2 Procarbazine--671-16-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, mechlorethamine, prednisone and procarbazine (10:00); AHFS Class: Antineoplastic agents prednisone, mechlorethamine, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine, mechlorethamine, prednisone and vincristine; References: 22; Journal Coden: BLOOAW; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmie L. Hall
N2 - The treatment of 38 pediatric Hodgkin's disease patients with either intensive radiation or chemotherapy with mechlorethamine, vincristine, prednisone and procarbazine is described. Results suggest that intensive radiation for localized disease and combination chemotherapy for advanced disease are at present the preferred forms of therapy for Hodgkin's disease in children.
KW - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW - Radiation--Hodgkin's disease--localized, in children;
KW - Antineoplastic agents--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW - Antineoplastic agents--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, in children;
KW - Antineoplastic agents--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW - Antineoplastic agents--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, in children;
KW - Combined therapy--mechlorethamine, prednisone, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW - Combined therapy--vincristine, mechlorethamine, prednisone and procarbazine--Hodgkin's disease, therapy, in children;
KW - Combined therapy--prednisone, mechlorethamine, procarbazine and vincristine--Hodgkin's disease, therapy, in children;
KW - Combined therapy--procarbazine, mechlorethamine, prednisone and vincristine--Hodgkin's disease, therapy, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Fales, Henry M
AU - Feldmann, Richard J
AU - Heller, Stephen R
AU - Milne, G W A
T1 - A conversational mass spectral search system. 4. the evolution of a system for the retrieval of mass spectral information
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1973/08//
VL - 13
IS - 3
M3 - Article
SP - 130
EP - 133
SN - 00219576
AB - A prototype of an interactive, conversational mass spectral search system, developed at the national institute of health, has been tested since september 1971 and is now being used by more than 200 scientists in the u.s. And canada. The response has led to management of the system being given to the mass spectrometry data centre, aldermaston, uk., for use by the international mass spectrometry community.
N1 - Accession Number: ISTA0803023; Fales, Henry M 1; Feldmann, Richard J; Heller, Stephen R; Milne, G W A; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: August 1973, Vol. 13 Issue 3, p130; Note: Update Code: 0800; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Edelson, Richard L.
AU - Smith, Richard W.
AU - Frank, Michael M.
AU - Green, Ira
T1 - IDENTIFICATION OF SUBPOPULATIONS OF MONONUCLEAR CELLS IN CUTANEOUS INFILTRATES I. DIFFERENTIATION BETWEEN B CELLS, T CELLS, AND HISTIOCYTES.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1973/08//
VL - 61
IS - 2
M3 - Article
SP - 82
EP - 89
SN - 0022202X
AB - Differentiation between bone marrow-derived lymphocytes (B cells), thymus-derived lymphocytes (T cells), and histiocytes has been achieved in tissue sections through utilization of known differences in cell membrane receptors. Sheep erythrocytes (E) were coated with either IgG or IgM antibody (A) to form IgG or IgM EA. IgM EA was incubated with mouse complement (C) to form IgM EAC. Cryosections were layered with 1gM EAC. 1gM EA. or lgG EA. and subpopulations of mononuclear cells could be distinguished from one another by the adherence or nonadherence of these reagents. B cells bound 1gM EAC. but not 1gM EA or EgG EA; histiocytes hound 1gM EAC and JgG EA. hut not 1gM EA; and F cells failed to hind any of these reagents. B cells were identified in a cutaneous leukemic infiltrate in a patient with B cell leukemia. Histiocytes were identified infiltrating the dermis and epidermis in a graft -versus- host reaction. A dermal lymphocytic infiltrate in a squamous cell carcinoma lesion did not bind IgO EA or 1gM EA. The remainder of the fresh tissue from this lesion was finely minced and filtered through a glass wool column. The lymphocytes in the filtrate were positive for human thymic lymphocyte antigen, establishing their T cell identity. It is therefore possible to distinguish between B cells, T cells, and histiocytes in skin lesions, this method should be valuable in the investigation of cutaneous mononuclear infiltrates through identification of effector cells, [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - MONONUCLEOSIS
KW - THYMUS
KW - MACROPHAGES
KW - ERYTHROCYTES
KW - CELL membranes
N1 - Accession Number: 12675403; Edelson, Richard L. 1 Smith, Richard W. 1 Frank, Michael M. 1 Green, Ira 1; Affiliation: 1: Immunology Branch, National Cancer Institute and Laboratory of Clinical Investigation, National Institutes of Heath, Betheshda, Maryland; Source Info: Aug73, Vol. 61 Issue 2, p82; Subject Term: LYMPHOCYTES; Subject Term: MONONUCLEOSIS; Subject Term: THYMUS; Subject Term: MACROPHAGES; Subject Term: ERYTHROCYTES; Subject Term: CELL membranes; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12675403
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Levy, R. I.;
AU - Rifkind, B. M.;
T1 - Lipid lowering drugs and hyperlipidemia
CT - Lipid lowering drugs and hyperlipidemia
JO - New Ethicals Med. Prog.
JF - New Ethicals Med. Prog.
Y1 - 1973/08/01/
VL - 10
IS - Aug
SP - 149
EP - 177
AD - Lipid Metabolism Branch, National Heart and Lung Institute, National Institutes, of Health, Bethesda, Maryland
N1 - Accession Number: 11-3034; Language: English; Chemical Name: Clofibrate--637-07-0; Publication Type: Review; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Douglas L. Thompson
N2 - Hyperlipidemia therapy is reviewed and the use of antilipemic agents as a supplement to dietary control is discussed. It was concluded that many drugs are effective but no drug works in all types of hyperlipoproteinemia. Cholestyramine is effective in type IIa, clofibrate is extremely effective in type III and it may sometimes be useful in types IV and V, but, when not contraindicated nicotinic acid is usually more effective.
KW - Cholestyramine--hyperlipoproteinemia-;
KW - Clofibrate--hyperlipoproteinemia-;
KW - Nicotinic acid--hyperlipoproteinemia-;
KW - Antilipemic agents--therapy--review, in patients;
KW - Nutrition--hyperlipoproteinemia--therapy, with drugs, discussion, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Eddy, Nathan B.
AU - May, Everette L.
T1 - The Search for a Better Analgesic.
JO - Science
JF - Science
Y1 - 1973/08/03/
VL - 181
IS - 4098
M3 - Article
SP - 407
EP - 414
SN - 00368075
N1 - Accession Number: 85362946; Eddy, Nathan B.; May, Everette L. 1; Affiliations: 1: Chief of medicinal chemistry, Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/ 3/1973, Vol. 181 Issue 4098, p407; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LIEBER, M. M.
AU - LIVINGSTON, D. M.
AU - TODARO, G. J.
T1 - Superinduction of Endogenous Type C Virus by 5-Bromodeoxyuridine from Transformed Mouse Clones.
JO - Science
JF - Science
Y1 - 1973/08/03/
VL - 181
IS - 4098
M3 - Article
SP - 443
EP - 444
SN - 00368075
AB - Certain transformed subclones of the mouse cell line BALB/3T3 release 5 to 15 times more type C virus per cell than the parent cell line after treatment with 5-bromodeoxyuridine. Virus release begins within 8 hours and exponentially increases for the first 24 to 48 hours. Superinducibility is associated with the transformed phenotype. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85362965; LIEBER, M. M. 1; LIVINGSTON, D. M. 1; TODARO, G. J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/ 3/1973, Vol. 181 Issue 4098, p443; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PETERS, ROBERT L.
AU - SPAHN, GERARD J.
AU - RABSTEIN, LOUISE S.
AU - KELLOFF, GARY J.
AU - HUEBNER, ROBERT J.
T1 - Murine C-type RNA Virus from Spontaneous Neoplasms: in vitro Host Range and Oncogenic Potential.
JO - Science
JF - Science
Y1 - 1973/08/17/
VL - 181
IS - 4100
M3 - Article
SP - 665
EP - 667
SN - 00368075
AB - Strain BALB/c mice harbor at least two host range variants of marine leukemia virus. One variant, which is host-cell tropic, is the predominant isolate from neoplastic tissues and produced lymphoreticular neoplasms when injected into BALB/c newborn mice. A second variant, whicht is isolated throughout life, grows poorly in host embryonic cells in culture and was not associated with lymphoreticular neoplasm induction when injected into newborn BALB/c mice [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85363064; PETERS, ROBERT L. 1; SPAHN, GERARD J. 1; RABSTEIN, LOUISE S. 1; KELLOFF, GARY J. 2; HUEBNER, ROBERT J. 2; Affiliations: 1: Microbiological Associates, Inc. Walkersville, Maryland 21793; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/17/1973, Vol. 181 Issue 4100, p665; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Forrest, J. N.;
AU - Heninger, G. R.;
AU - Levy, S. T.;
T1 - Lithium-induced diabetes insipidus: manic symptoms, brain and electrolyte correlates, and chlorothiazide treatment
CT - Lithium-induced diabetes insipidus: manic symptoms, brain and electrolyte correlates, and chlorothiazide treatment
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/09/01/
VL - 130
IS - Sep
SP - 1014
EP - 1018
SN - 0002953X
AD - Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06512
AD - (Reprints: Adult Psychiatry Branch, Psychiatric Assessment Section, National Institute of Mental Health, Building 10, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 11-1406; Language: English; Chemical Name: Lithium--7439-93-2 Chlorothiazide--58-94-6; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium (40:28); AHFS Class: Diuretics chlorothiazide; References: 19; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Drug Evaluations
N2 - A patient with lithium-induced, vasopressin-insensitive diabetes insipidus was studied during 2 consecutive manic episodes that were successfully treated with lithium. Polyuria occurred several days after lithium-induced brain electrical changes were observed, and at serum lithium concentrations close to 1.0 meq./l. Polyuria began during a period of behavioral improvement and persisted after the manic symptoms subsided. Polyuria did not occur in association with serum lithium concentrations over 1.8 meq./l., and a 4-fold increase in sodium intake did not reduce the polyuria. Chlorothiazide reduced polyuria and permitted the patient to continue the lithium treatment.
KW - Lithium--adverse reactions-;
KW - Chlorothiazide--diabetes insipidus-;
KW - Psychotherapeutic agents--lithium--adverse reactions, diabetes insipidus treated with chlorothiazide, in patient;
KW - Drugs, adverse reactions--lithium--diabetes insipidus, treated with chlorothiazide, in patient;
KW - Diuretics--chlorothiazide--diabetes insipidus, lithium induced, therapy, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Valdlamudi, S.;
AU - Krishna, B.;
AU - Reddy, V.;
AU - Goldin, A.;
T1 - Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178y) mice
CT - Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178y) mice
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1973/09/01/
VL - 33
IS - Sep
SP - 2014
EP - 2019
SN - 00085472
AD - Microbiological Associates, Inc., and National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-1475; Language: English; Chemical Name: Asparaginase--9015-68-3 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents asparaginase; References: 20; Journal Coden: CNREA8; Section Heading: Drug Interactions
N2 - In this study, therapeutic synergism was observed in combination chemotherapy of leukemia L5178Y with L-asparaginase (I) plus methotrexate (II) over a variety of treatment schedules. Therapeutic synergism occurred when a single dose of I was followed at varying times (immediately or up to 6 hr. later) by daily treatment with II. It was also observed when daily treatment with II was initiated just prior to or up to 6 hr. before a single treatment with I. Similarly, increases in survival time were observed in leukemic mice when daily treatment with II was initiated 4 days prior to a single dose of I on day 7. In one instance, the occurrence of therapeutic synergism was dependent upon the sequence of drug administration. Whereas therapeutic synergism was observed when mice bearing L5178Y leukemia were given 5 daily treatments of II followed 3 days later by 5 daily treatments of I; it did not occur when I preceded II on the same schedule. Treatment with II was found to be equally effective against leukemia L5178Y and its I resistant line.
KW - Asparaginase--interactions-;
KW - Methotrexate--interactions-;
KW - Antineoplastic agents--methotrexate--interactions, asparaginase, synergism, leukemia therapy, schedule dependent, in mice;
KW - Antineoplastic agents--asparaginase--interactions, methotrexate, synergism, leukemia therapy, schedule dependent, in mice;
KW - Drug interactions--asparaginase and methotrexate--synergism, leukemia therapy, schedule dependent, in mice;
KW - Drug interactions--methotrexate and asparaginase--synergism, leukemia therapy, schedule dependent, in mice;
KW - Dosage schedules--methotrexate and asparaginase--leukemias, therapy, synergism, schedule dependent, in mice;
KW - Dosage schedules--asparaginase and methotrexate--leukemias, therapy, synergism, schedule dependent, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Halverson, Charles F.
AU - Jr.
AU - Waldrop, Mary F.
T1 - The Relations of Mechanically Recorded Activity Level to Varieties of Preschool Play Behavior.
JO - Child Development
JF - Child Development
Y1 - 1973/09//
VL - 44
IS - 3
M3 - Article
SP - 678
EP - 681
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12115665; Halverson, Charles F. Jr. 1 Waldrop, Mary F. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Sep1973, Vol. 44 Issue 3, p678; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1467-8624.ep12115665
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12115665&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patel, Kantilal M.
AU - Hoel, David G.
T1 - A Nonparametric Test for Interaction in Factorial Experiments.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1973/09//
VL - 68
IS - 343
M3 - Article
SP - 615
SN - 01621459
AB - A measure of interaction in factorial experiments is introduced and the problem of estimating it and testing it for nullity is considered. The asymptotic power efficiencies are studied and Monte Carlo power comparisons are made when samples are drawn from normal and scale contaminated compound normal distributions. The proposed test showed improved power over the normal theory F test and other rank tests for moderately large samples taken from the heavy tailed distributions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONPARAMETRIC statistics
KW - DISTRIBUTION (Probability theory)
KW - MONTE Carlo method
KW - FACTOR analysis
KW - FACTORIAL experiment designs
KW - EXPERIMENTAL design
KW - F-distribution
KW - NUMERICAL analysis
N1 - Accession Number: 4607048; Patel, Kantilal M. 1; Hoel, David G. 2; Affiliations: 1: NIH Visiting Fellow, Biometry Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.; 2: Chief, Biometry Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.; Issue Info: Sep73, Vol. 68 Issue 343, p615; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MONTE Carlo method; Subject Term: FACTOR analysis; Subject Term: FACTORIAL experiment designs; Subject Term: EXPERIMENTAL design; Subject Term: F-distribution; Subject Term: NUMERICAL analysis; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Weiss, George H.
T1 - Likelihood: An Account of the Statistical Concept of Likelihood and its Application to Scientific Inference (Book).
JO - Operations Research
JF - Operations Research
Y1 - 1973/09//Sep/Oct73
VL - 21
IS - 5
M3 - Book Review
SP - 1172
EP - 1173
PB - INFORMS: Institute for Operations Research
SN - 0030364X
AB - Reviews the book "Likelihood: An Account of the Statistical Concept of Likelihood and its Application to Scientific Inference," by A. W. F. Edwards.
KW - STATISTICS
KW - NONFICTION
KW - EDWARDS, A. W. F.
KW - LIKELIHOOD: An Account of the Statistical Concept of Likelihood & Its Application to Scientific Inference (Book)
N1 - Accession Number: 8735954; Weiss, George H. 1; Affiliations: 1: National Institutes of Health; Issue Info: Sep/Oct73, Vol. 21 Issue 5, p1172; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: LIKELIHOOD: An Account of the Statistical Concept of Likelihood & Its Application to Scientific Inference (Book); People: EDWARDS, A. W. F.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rosenberg, Morris
T1 - THE LOGICAL STATUS OF SUPPRESSOR VARIABLES.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1973///Fall73
VL - 37
IS - 3
M3 - Article
SP - 359
EP - 372
PB - Oxford University Press / USA
SN - 0033362X
AB - While social scientists are aware that the relationship between an independent and dependent variable may be spurious, they are much less aware that the absence of relationship may be equally spurious. The chief reason is that the relationship is concealed by a suppressor test factor. This paper supplements earlier discussions of this topic by considering the logical status of suppressor test factors and compensating influences. Examples of antecedent, intervening, and component suppressor variables and of compensating influences are provided. It shows that, in a causal sense, standard test factors and suppressor test factors generate opposite interpretations of spuriousness, but in a formal sense they are the same. Several substantive contributions of suppressor variables to social science are discussed. Suppressor variables are not rarities, but may actually appear as often as standard test factors in research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Interpersonal relations
KW - Social scientists
KW - Points of contact (Conflict of laws)
KW - Social sciences
KW - Variables (Mathematics)
KW - Social factors
N1 - Accession Number: 5413691; Rosenberg, Morris 1,2; Affiliations: 1: Research Sociologist, National Institute of Mental Health; 2: Adjunct Professor, The American University; Issue Info: Fall73, Vol. 37 Issue 3, p359; Thesaurus Term: Interpersonal relations; Subject Term: Social scientists; Subject Term: Points of contact (Conflict of laws); Subject Term: Social sciences; Subject Term: Variables (Mathematics); Subject Term: Social factors; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 2013-20922-008
AN - 2013-20922-008
AU - Stierlin, Helm
T1 - The adolescent as delegate of his parents.
JF - Australian and New Zealand Journal of Psychiatry
JO - Australian and New Zealand Journal of Psychiatry
JA - Aust N Z J Psychiatry
Y1 - 1973/09//
VL - 7
IS - 3
SP - 249
EP - 256
CY - United Kingdom
PB - Blackwell Publishing
SN - 0004-8674
SN - 1440-1614
AD - Stierlin, Helm, Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-20922-008. Partial author list: First Author & Affiliation: Stierlin, Helm; Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Informa Healthcare; Sage Publications. Release Date: 20131028. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Parents; Separation Reactions. Minor Descriptor: Loyalty; Offspring. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 8. Issue Publication Date: Sep, 1973.
AB - The concept of the adolescent as a delegate of his parents illuminates many vicissitudes of the separation process between parents and their adolescent offspring, and also introduces differing treatment perspectives. Where an adolescent is delegated, he is encouraged and allowed to move out of the parental orbit—up to a point! He is then held on a long leash, as it were, and his separation is made limited and conditional. Such qualified 'sending out' is implied in the original Latin word 'delegate', which means, first, to send out and, second, to entrust with a mission. The latter meaning implies that the delegate—although sent out—remains beholden to the person who sends him out. This becomes possible only on the basis of a strong, though often invisible and selective, loyalty. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent offspring
KW - delegate
KW - vicissitudes
KW - separation process
KW - treatment perspectives
KW - loyalty
KW - parents
KW - 1973
KW - Adolescent Attitudes
KW - Parents
KW - Separation Reactions
KW - Loyalty
KW - Offspring
KW - 1973
DO - 10.3109/00048677309159757
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - OFFICER, J. EARLE
AU - TECSON, NORA
AU - ESTES, JOHN D.
AU - FONTANILLA, EVELYN
AU - RONGEY, ROBERT W.
AU - GARDNER, MURRAY B.
T1 - Isolation of a Neurotropic Type C Virus.
JO - Science
JF - Science
Y1 - 1973/09/07/
VL - 181
IS - 4103
M3 - Article
SP - 945
EP - 947
SN - 00368075
AB - A neurogenic paralysis of the lower limb can be induced and serially transmitted in mice by a nontransforming type C viruts strain that originated in an embryo of a wild mouse. The virus exerted a neurotropic effect on the anterior horn neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117261; OFFICER, J. EARLE 1; TECSON, NORA 1; ESTES, JOHN D. 2; FONTANILLA, EVELYN 3; RONGEY, ROBERT W. 3; GARDNER, MURRAY B. 3; Affiliations: 1: Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033; 2: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Departmnent of Pathology, University of Southern California School of Medicine; Issue Info: 9/ 7/1973, Vol. 181 Issue 4103, p945; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SMITH JR., J. CECIL
AU - MCDANIEL, E. G.
AU - FAN, F. F.
AU - HALSTED, JAMES A.
T1 - Zinc: A Trace Element Essential in Vitamin A Metabolism.
JO - Science
JF - Science
Y1 - 1973/09/07/
VL - 181
IS - 4103
M3 - Article
SP - 954
EP - 955
SN - 00368075
N1 - Accession Number: 85117266; SMITH JR., J. CECIL 1; MCDANIEL, E. G. 1; FAN, F. F. 1; HALSTED, JAMES A. 1; Affiliations: 1: Veterans Administration Hospital, Washington, D.C. 20422, and National Institutes of Health, Bethesda, Maryland 20014, and School of Medicine, George Washington University, Washington, D.C. 20005; Issue Info: 9/ 7/1973, Vol. 181 Issue 4103, p954; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BENNETT, H. STANLEY
AU - ALBRO, PHILLIP W.
T1 - PCB's in Microscope Immersion Oil.
JO - Science
JF - Science
Y1 - 1973/09/14/
VL - 181
IS - 4104
M3 - Article
SP - 990
EP - 990
SN - 00368075
N1 - Accession Number: 85117271; BENNETT, H. STANLEY 1; ALBRO, PHILLIP W. 2; Affiliations: 1: Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill 27514; 2: Analytical and Synthetic Chemistry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 9/14/1973, Vol. 181 Issue 4104, p990; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pommier, Jacques
AU - Sokoloff, Louis
AU - Nunez, Jacques
T1 - Enzymatic Iodination of Protein.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1973/09/15/
VL - 38
IS - 3
M3 - Article
SP - 497
EP - 506
PB - Wiley-Blackwell
SN - 00142956
AB - The initial rate of I2 formation catalyzed by horse-radish peroxidase exhibited a clear sigmoid relationship with respect to the concentration of I--. These data were found to fit an equa- tion based on a model which predicts a second-order dependence on iodide concentration and are consistent with a bimolecular reaction between two I- ions on the surface of the enzyme. Such a model presumes two sites for the substrate on the enzyme. The initial rate of lysozyme iodination also exhibited a clear sigmoid relationship with respect to concentration of I-. The sigmoidicity increased with the lysozyme concentration. These experimental data fit a random-ordered sequence of substrate fixation but with one of the two possible sequences kinetically preferred. These results also suggest that lysozyme interacts with the enzyme and that there are two sites for substrate addition on the surface of the enzyme. When the ratio of the concentrations of both substrates, iodide and lysozyme, is varied, the rates of formation of each product, I2 or iodinated protein, also vary; the lower the iodide/protein ratio, the lower the I2 yield and the higher the rate of protein iodination. Studies on the influence of pH on the nature of the product showed that I2 formation is favored at acidic pH and protein iodination at more alkaline pH. These results are also consistent with a two-site model for the enzyme, both sites being able to fix either two iodide ions or one iodide ion and one lysozyme molecule. The affinity of the sites for each one of the two substrates differs according to the pH. This conclusion was confirmed by the observation that iodination of free tyrosine could be obtain- ed with very good yields provided that the pH of the reaction was adjusted to avoid either com- plete dimerization of free tyrosine, which is favored at alkaline pH, or I2 formation which is favor- ed at low pH. These results and other quantitative data on the stoiehiometry of H2O2 consumption do not establish unequivocally which is the oxidized iodide-reacting species, I+ or Io. However, they indicate that I2 is not the iodinating species in the protein iodination reaction catalyzed by horse- radish peroxidase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEROXIDASE
KW - LYSOZYMES
KW - PHENOL oxidase
KW - ENZYMOLOGY
KW - ANIMAL models in research
KW - BIOCHEMISTRY
N1 - Accession Number: 13660720; Pommier, Jacques 1 Sokoloff, Louis 1 Nunez, Jacques 1; Affiliation: 1: Unité de Recherche sur la Glande Thyroïde et la Régulation Hormonale de l'Institut National de la Santé et de la Recherche Médicale, Bicêtre, and Section on Developmental Neurochemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland; Source Info: 1973, Vol. 38 Issue 3, p497; Subject Term: PEROXIDASE; Subject Term: LYSOZYMES; Subject Term: PHENOL oxidase; Subject Term: ENZYMOLOGY; Subject Term: ANIMAL models in research; Subject Term: BIOCHEMISTRY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SINGER, MAXINE
AU - SOLL, DIETER
T1 - Guidelines for DNA Hybrid Molecules.
JO - Science
JF - Science
Y1 - 1973/09/21/
VL - 181
IS - 4105
M3 - Article
SP - 1125
EP - 1125
SN - 00368075
N1 - Accession Number: 85117318; SINGER, MAXINE 1; SOLL, DIETER 2; Affiliations: 1: Room 9N-119, Building 10, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; Issue Info: 9/21/1973, Vol. 181 Issue 4105, preceding p1125; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KEEPER, LARRY K.
AU - ROLLER, PETER P.
T1 - N-Nitrosation by Nitrite Ion in Neutral and Basic Medium.
JO - Science
JF - Science
Y1 - 1973/09/28/
VL - 181
IS - 4106
M3 - Article
SP - 1245
EP - 1247
SN - 00368075
AB - Formaldehyde catalyzed the conversion of various secondary amines to nitrosamines in the pH range 6.4 to 11.0. Chloral was also an eflective catalyst. The reaction proceeds easily enough to have potential synthetic applications; the proposed mechanism could explain sonme reported anomalies regarding the synthesis of carcinogenic N-nitroso compounds in vivo and in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117366; KEEPER, LARRY K. 1; ROLLER, PETER P. 1; Affiliations: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/28/1973, Vol. 181 Issue 4106, p1245; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Duttera, M. J.;
AU - Bleyer, W. A.;
AU - Pomeroy, T. C.;
AU - Leventhal, C. M.;
AU - Leventhal, B. G.;
T1 - Irradiation, methotrexate toxicity, and the treatment of meningeal leukemia
CT - Irradiation, methotrexate toxicity, and the treatment of meningeal leukemia
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/09/29/
VL - 2
IS - Sep 29
SP - 703
EP - 707
SN - 00237507
AD - Pediatric Oncology Branch and Radiation Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-2049; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 23; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Thirty-one patients with meningeal leukemia were randomized to therapy with intrathecal methotrexate (I) with and without 2400r to the cranial vault. Induction therapy was given with I at 15 mg./sq.m. every 2-3 days until abnormal cells disappeared from the cerebrospinal fluid to a maximum of 8 doses. If CNS remission was not obtained at this point treatment was considered to have failed. Once abnormal cells had disappeared from the spinal fluid, a consolidation period of 6 weekly doses was given followed by monthly maintenance injections. If patients showed severe toxic reactions they were treated instead for consolidation or maintenance with cytosine arabinoside 30 mg./sq.m./dose on the same schedule. Remissions were achieved in 29 patients. Remission duration was significantly longer (234+ days) in the group receiving I alone than in those receiving I and irradiation (125 days). A spectrum of I toxicity was seen after intrathecal administration ranging in severity from chemical arachnoiditis which was common (17 patients) through transient paresis (1 patient) to encephalopathy (2 patients). These toxicities were just as common in patients receiving preservative-free I as in those receiving I with preservative, and therefore should be ascribed to direct toxic effects of I itself or its breakdown products rather than preservative. The neurotoxicity of I must be taken into account in evaluating the risks and benefits of the therapy for meningeal leukemia.
KW - Methotrexate--alone and with radiation-;
KW - Antineoplastic agents--methotrexate--alone and with radiation, leukemia, meningeal, therapy, in patient;
KW - Toxicity--methotrexate--side effects, during therapy for meningeal leukemia, in patient;
KW - Preservatives--methotrexate--toxicity, lack, intrathecal, in patients;
KW - Toxicity--preservatives--lack, methotrexate intrathecal, in patients;
KW - Radiation--and methotrexate--leukemias, meningeal, therapy, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Falk, Stephen A.
T1 - Letter: Environmental noise.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/10//
VL - 63
IS - 10
M3 - Letter
SP - 833
EP - 836
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "The Non-Auditory Effects of Environmental Noise," by Karl Kryter in the March 1972 issue.
KW - Noise pollution
KW - Letters to the editor
N1 - Accession Number: 19876927; Falk, Stephen A. 1; Affiliations: 1: Biophysics & Instrumentation Section, Research Services Branch, National Institute of Environmental Health Sciences, P.O. Box 12233; Issue Info: Oct1973, Vol. 63 Issue 10, p833; Thesaurus Term: Noise pollution; Subject Term: Letters to the editor; Number of Pages: 4p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Eyres, Sandra J.
T1 - Public Health Nursing Section Report of the 1972 APHA Smoking Survey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/10//
VL - 63
IS - 10
M3 - Article
SP - 846
EP - 852
PB - American Public Health Association
SN - 00900036
AB - The article presents a survey which identifies the smoking behavior of American Public Health Association (APHA) members in the U.S. The association conducted the survey in order to determine how they could best contribute to the goal of decreasing cigarette smoking within the country. It has shown additional evidence that health professionals' own smoking behavior is related to their attitudes and actions in urging a change in the smoking behavior of those to whom they give care. In addition, the said survey presented the percentage of APHA members who ever tried to persuade someone to stop smoking.
KW - Smoking
KW - Cigarette smokers
KW - Public health
KW - Health surveys
KW - Associations, institutions, etc. -- Membership
KW - Medical care
KW - Medical personnel
KW - United States
KW - American Public Health Association (APHA)
KW - Smoking survey
KW - American Public Health Association
N1 - Accession Number: 7971063; Eyres, Sandra J. 1; Affiliations: 1: Nurse Consultant, Division of Nursing, National Institutes of Health, Bethesda, Maryland; Issue Info: Oct1973, Vol. 63 Issue 10, p846; Thesaurus Term: Smoking; Thesaurus Term: Cigarette smokers; Thesaurus Term: Public health; Subject Term: Health surveys; Subject Term: Associations, institutions, etc. -- Membership; Subject Term: Medical care; Subject Term: Medical personnel; Subject: United States; Author-Supplied Keyword: American Public Health Association (APHA); Author-Supplied Keyword: Smoking survey ; Company/Entity: American Public Health Association; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Schein, P.;
AU - Kahn, R.;
AU - Gorden, P.;
AU - Wells, S.;
AU - DeVita, V. T.;
T1 - Streptozotocin for malignant insulinomas and carcinoid tumor
CT - Streptozotocin for malignant insulinomas and carcinoid tumor
JO - Archives of Internal Medicine (USA)
JF - Archives of Internal Medicine (USA)
Y1 - 1973/10/01/
VL - 132
IS - Oct
SP - 555
EP - 561
SN - 00039926
AD - National Institutes of Health, Medicine Branch, NC1, Bethesda, Maryland 20014
N1 - Accession Number: 11-2411; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozotocin; References: 30; Journal Coden: AIMDAP; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Four patients with metastatic insulinoma were treated with streptozotocin, with one complete remission lasting one year. The patient received 4 g.; major bone marrow depression was seen. Serum half life was 15 minutes.
KW - Streptozotocin--effects-;
KW - Antineoplastic agents--streptozotocin--effects, metastatic insulinoma, in patients;
KW - Toxicity--streptozotocin--side effects, bone marrow depression, in patients;
KW - Half-life--streptozotocin--blood levels, metastatic insulinoma therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lee, Douglas H. K.
T1 - Specific Approaches to Health Effects of Pollutants.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1973/10//
VL - 29
IS - 8
M3 - Article
SP - 45
EP - 47
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21583355; Lee, Douglas H. K. 1; Affiliation: 1: Associate Director, National Institute of Environmental Health Sciences; Source Info: Oct1973, Vol. 29 Issue 8, p45; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Buja, L. J.;
AU - Ferrans, V. J.;
AU - Mayer, R. J.;
AU - Roberts, W. C.;
AU - Henderson, E. S.;
T1 - Cardiac ultrastructural changes induced by daunorubicin therapy
CT - Cardiac ultrastructural changes induced by daunorubicin therapy
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1973/10/01/
VL - 32
IS - Oct
SP - 771
EP - 788
AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 11-2023; Language: English; Trade Name: Daunorubicin; Generic Name: Daunomycin; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunomycin; References: 65; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Linda K. McCoy
N2 - Histologic and ultrastructural studies were made of the hearts of 6 patients with acute leukemias to elucidate the mechanisms of the cardiotoxicity induced by daunorubicin (daunomycin). Three patients had received relatively high doses (455, 460, and 500 mg./sq. m.); one a relatively low total dose (120 mg./sq.m.); 2 patients who had not been treated with this drug served as controls. Histologic changes observed only in the hearts of the 3 patients with relatively high doses consisted of scattered foci of damaged, degenerating, and atrophic muscle cells. These changes were more widespread in the patient who had received the highest dose and developed clinical signs of cardiotoxicity. Alterations of chromatin were observed in 10% of nuclei of cardiac muscle cells in the 3 patients treated with relatively high doses of daunomycin. These changes consisted of a transformation of variable amounts of chromatin into thick fibers, intermediate-sized fibers, and thin filaments. These alterations were interpreted as representing various stages of uncoiling and unraveling of chromatin and were considered to be related to the phenomenon of intercalation of daunomycin into DNA. Cardiotoxicity may be related to the inability of non-dividing cardiac muscle cells to repair daunomycin-induced alterations in DNA.
KW - Daunomycin--toxicity-;
KW - Antineoplastic agents--daunomycin--toxicity, studies, cardiac, in patients;
KW - Toxicity--daunomycin--studies, cardiac, in patients;
KW - Dosage--daunomycin--toxicity, studies, cardiac, correlations, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cohen, M. H.;
T1 - Enhancement of the antitumor effect of 1,3-bis (2-chloroethyl) 1-nitrosourea by chlorpromazine and caffeine
CT - Enhancement of the antitumor effect of 1,3-bis (2-chloroethyl) 1-nitrosourea by chlorpromazine and caffeine
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/10/01/
VL - 51
IS - Oct
SP - 1323
EP - 1325
SN - 00278874
AD - NCI-VA Medical Oncology Branch, National Cancer Institute, Veterans Administration Hospital, 50 Irving Street N.W., Washington, D. C.
N1 - Accession Number: 11-1842; Language: English; Trade Name: BCNU; Generic Name: Carmustine; Chemical Name: Chlorpromazine--50-53-3 Carmustine--154-93-8 Caffeine--58-08-2; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine, caffeine and carmustine (28:20); AHFS Class: Central nervous system stimulants caffeine, carmustine and chlorpromazine (10:00); AHFS Class: Antineoplastic agents carmustine, caffeine and chlorpromazine; References: 13; Section Heading: Drug Evaluations
N2 - A study of combined therapy with chlorpromazine, BCNU (carmustine), and caffeine, showed markedly increased survival of murine L1210 leukemic mice over treatment with BCNU alone. All 3 drugs had to be given together, because neither chlorpromazine plus BCNU nor BCNU plus caffeine treatment improved survival relative to an appropriate control group. The optimal time for chlorpromazine treatment was 6 hours before BCNU. Prior exposure to caffeine of both recipient mice and L1210 cells used for transplantation did not affect therapeutic response. The mechanism of enhancement of BCNU by chlorpromazine and caffeine is unknown.
KW - Chlorpromazine--caffeine and carmustine-;
KW - Carmustine--caffeine and chlorpromazine-;
KW - Caffeine--carmustine and chlorpromazine-;
KW - Combined therapy--carmustine, caffeine, and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Combined therapy--caffeine, carmustine, and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Combined therapy--chlorpromazine, caffeine, and carmustine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Tranquilizers--chlorpromazine, caffeine and carmustine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Central nervous system stimulants--caffeine, carmustine and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Antineoplastic agents--carmustine, caffeine and chlorpromazine--leukemias, therapy, improved over carmustine alone, in mice;
KW - Dosage schedules--chlorpromazine, caffeine and carmustine--pretreatment, with chlorpromazine, therapy, in leukemic mice;
KW - Dosage schedules--carmustine, chlorpromazine and caffeine--pretreatment, with chlorpromazine, therapy, in leukemic mice;
KW - Drug interactions--carmustine, chlorpromazine and caffeine--potentiation, effects, over carmustine alone, in leukemic mice;
KW - Drug interactions--caffeine, carmustine and chlorpromazine--potentiation, effects, over carmustine alone, in leukemic mice;
KW - Drug interactions--chlorpromazine, caffeine and carmustine--potentiation, effects, over carmustine alone, in leukemic mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chirigos, M. A.;
AU - Pearson, J. W.;
T1 - Cure of murine leukemia with drug and interferon treatment
CT - Cure of murine leukemia with drug and interferon treatment
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/10/01/
VL - 51
IS - Oct
SP - 1367
EP - 1368
SN - 00278874
AD - Viral Leukemia and Lymphoma Branch, National Cancer Institute, NIH, Public Health Service, U. S. Department of Health Education and Welfare, Bethesda, Maryland
N1 - Accession Number: 11-1474; Language: English; Chemical Name: Interferon--9008-11-1; References: 13; Section Heading: Drug Interactions; Pharmacology
N2 - A discussion of the effects of interferon and drug therapy in the treatment of leukemia is presented. Interferon has limited in vivo antitumor activity when host tumor load is great. When systemic leukemia is arrested by drug therapy which leads to a reduction of tumor cells, subsequent treatment with interferon leads to a significant number of cures. The combined drug and interferon treatment exerts a synergistic antitumor effect.
KW - Interferon--interactions-;
KW - Antineoplastic agents--interactions--interferon, synergism, leukemia therapy;
KW - Drug interactions--interferon and antineoplastic agents--synergism, leukemia therapy;
KW - Drug interactions--antineoplastic agents and interferon--synergism, leukemia therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Pavalko, Ronald M.
AU - Lutterman, Kenneth G.
T1 - CHARACTERISTICS OF WILLING AND RELUCTANT RESPONDENTS.
JO - Pacific Sociological Review
JF - Pacific Sociological Review
Y1 - 1973/10//
VL - 16
IS - 4
M3 - Article
SP - 463
EP - 476
SN - 00308919
AB - The effects of education, socioeconomic status, and I.Q. on responses to a mail questionnaire.
KW - PUBLIC opinion polls
KW - DIRECT marketing
KW - POPULATION
KW - PROBABILITY theory
KW - LONGITUDINAL method
KW - SOCIAL classes
KW - SOCIAL surveys
KW - QUESTIONNAIRES
KW - Respondents
N1 - Accession Number: 15506063; Pavalko, Ronald M. 1; Lutterman, Kenneth G. 2; Affiliations: 1 : Florida State University.; 2 : National Institute of Mental Health.; Source Info: Oct1973, Vol. 16 Issue 4, p463; Historical Period: 1957 to 1965; Subject Term: PUBLIC opinion polls; Subject Term: DIRECT marketing; Subject Term: POPULATION; Subject Term: PROBABILITY theory; Subject Term: LONGITUDINAL method; Subject Term: SOCIAL classes; Subject Term: SOCIAL surveys; Subject Term: QUESTIONNAIRES; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
ID - 2006-06243-030
AN - 2006-06243-030
AU - Waskow, Irene E.
AU - Katz, Martin M.
T1 - Exploring Subjective Responses.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1973/10//
VL - 18
IS - 10
SP - 486
EP - 488
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06243-030. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waskow, Irene E.; National Institute of Mental Health, Section on Psychotherapy and Behavioral Intervention, Clinical Research Branch, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Marijuana; Toxicity. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Tart, Charles T. On Being Stoned=Palo Alto: Science and Behavior Books, 1971. Pp. xvii + 333. $7.95; 1971. Page Count: 3. Issue Publication Date: Oct, 1973.
AB - Reviews the book, On Being Stoned by Charles T. Tart (see record [rid]1972-08365-000[/rid]). The purpose of the study described in this book was, according to Tart, to get an overall look at marijuana intoxication as it occurs in the ordinary world, to get an idea of the range of possible effects, the frequency of their occurrence, and the intoxication levels at which they occur. In summary, this book is a detailed report of the results of a fairly interesting and useful study, if taken for what it is--an exploratory study of subjective responses to marijuana of a fairly selective population. In general, we viewed this study as a useful effort, but with fairly limited scientific and theoretical implications for the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marijuana intoxication
KW - subjective responses
KW - 1973
KW - Drug Abuse
KW - Marijuana
KW - Toxicity
KW - 1973
U2 - Tart, Charles T. (1971); On Being Stoned; Palo Alto: Science and Behavior Books, 1971. Pp. xvii + 333. $7.95
DO - 10.1037/0011676
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41581-002
AN - 2013-41581-002
AU - Brown, Bertram S.
T1 - A national view of mental health.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/10//
VL - 43
IS - 5
SP - 700
EP - 705
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41581-002. PMID: 4355122 Partial author list: First Author & Affiliation: Brown, Bertram S.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Orthopsychiatric Association, 1973, New York, NY, US. Conference Note: This article was presented at the aforementioned conference. Major Descriptor: Community Mental Health Centers; Orthopsychiatry; Scientific Communication. Minor Descriptor: Professional Organizations; Clinical Models. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 6. Issue Publication Date: Oct, 1973.
AB - This article provides an overview of the Presidential Session of the 1973 annual meeting of the American Orthopsychiatric Association, held in New York. The theme of the Session was to provide a national view of mental health. If the definition of mental health includes racism, poverty, and violence then one deals with a different quantitative and qualitative set of issues than if one limits the mental health domain to serious overt mental illness. The assignment of providing a national perspective on mental health is so complex that the author uses a limited model, drawn from oversimplified biology-fully realizing that Ortho is not the place to overdraw medical models and medical analogies. One way to begin to gauge the nation's mental health is to take the pulse, or count the beats. Clearly, the federal direction at the moment is away from Washington, to ward the local community. The Administration has recommended that there be no more federal support of Community Mental Health Centers, but rather that we encourage local support. The author's view of mental health cannot be definitive or conclusive, but it is optimistic. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - American Orthopsychiatric Association
KW - medical models
KW - community mental health centers
KW - 1973
KW - Community Mental Health Centers
KW - Orthopsychiatry
KW - Scientific Communication
KW - Professional Organizations
KW - Clinical Models
KW - 1973
DO - 10.1111/j.1939-0025.1973.tb00840.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - May, J. E.;
AU - Rosse, W.;
AU - Frank, M. M.;
T1 - Paroxysmal nocturnal hemoglobinuria: alternate complement pathway mediated lysis induced by magnesium
CT - Paroxysmal nocturnal hemoglobinuria: alternate complement pathway mediated lysis induced by magnesium
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1973/10/04/
VL - 289
IS - Oct 4
SP - 705
EP - 709
SN - 00284793
AD - National Institutes of Health, Building 10, Room 11N-104, LCI, NIAID, Bethesda, Maryland 20014
N1 - Accession Number: 11-2098; Language: English; Chemical Name: Magnesium--7439-95-4 Calcium--7440-70-2; Therapeutic Class: (40:12); AHFS Class: Electrolytes magnesium (40:12); AHFS Class: Electrolytes calcium; References: 20; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - The central role of the magnesium ion in the lysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria by normal serum was demonstrated in this study. This lysis was examined as a function of calcium and magnesium ion concentration in 8 patients and 8 normal donors. The addition of as little as 3 X 10\SU/\-/4\BS/ molar magnesium (0.6 meq./l.) to normal human serum initiated lysis of cells from patients with the disorder, via the alternate pathway of complement activation, and markedly potentiated the lysis of these cells in acidified serum by the same pathway. This finding led to a simple modification of the acidified serum lysis test (Ham test), which renders it more accurate in the diagnosis of paroxysmal nocturnal hemoglobinuria and more precise in delineation of the abnormal erythrocyte populations. Also demonstrated is the fact that calcium ion inhibits lysis of the abnormal cells in acidified and nonacidified human serum. Small changes in the concentration of these cations may result in spontaneous activation of the alternate complement pathway, thereby precipitating hemolytic attacks.
KW - Magnesium--ions-;
KW - Calcium--ions-;
KW - Electrolytes--magnesium--ions, effects on erythrocyte lysis, from patients with paroxysmal nocturnal hemoglobinuria, in vitro;
KW - Electrolytes--calcium--ions, effects on erythrocyte lysis, from patients with paroxysmal nocturnal hemoglobinuria, in vitro;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - LIEBER, M. M.
AU - BENVENISTE, R. E.
AU - LIVINGSTON, D. M.
AU - TODARO, G. J.
T1 - Mammalan Cells in Culture Frequently Release Type C Viruses.
JO - Science
JF - Science
Y1 - 1973/10/05/
VL - 182
IS - 4107
M3 - Article
SP - 56
EP - 59
SN - 00368075
AB - Cell cultures commonly used in animal cell research, both cell strains andcontinuous cell lines from various mammalian species, spontaneously produce type C RNA viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117397; LIEBER, M. M. 1; BENVENISTE, R. E. 1; LIVINGSTON, D. M. 1; TODARO, G. J. 1; Affiliations: 1: Viral Leukemia and Lymphoina Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/ 5/1973, Vol. 182 Issue 4107, p56; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bleyer, W. A.;
AU - Drake, J. C.;
AU - Chabner, B. A.;
T1 - Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia
CT - Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1973/10/11/
VL - 289
IS - Oct 11
SP - 770
EP - 773
SN - 00284793
AD - Building 10, Room 6N119, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-1232; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 16; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Joan Lentine
N2 - This report describes the pharmacokinetics of methotrexate disappearance from the cerebrospinal fluid after intrathecal therapy or prophylaxis in 25 patients with acute leukemia, and presents evidence relating neurotoxic reactions in 5 patients to elevated levels of methotrexate concentrations in the cerebrospinal fluid. All patients received preservative free methotrexate at 12 or 15 mg./sq. m./dose. The drug was administered twice weekly until the cerebrospinal fluid leukemic cells disappeared, or for 5 doses in patients treated prophylactically. The drug was injected at a concentration of 1 mg./ml. and in a volume of 12 to 15 ml./sq. m., after isovolumetric removal of cerebrospinal fluid. Methotrexate concentration was determined by the dihydrofolate reductase inhibition method, with use of enzyme derived from L1210 leukemic cells resistant to methotrexate. In 20 patients with no manifestations of neurotoxicity, the mean antifolate value in the cerebrospinal fluid was 1.7 \X/ 10\SU/\-/7\BS/M two days after administration of 12 to 15 mg./sq. m., and declined thereafter with a half-life of 12 to 18 hours. Five patients with severe neurotoxicity had cerebrospinal fluid methotrexate concentrations averaging 13.8 times higher than the mean, and these concentrations were consistently higher than the range of antifolate values in the asymptomatic patients. One patient with values 20 to 100 times greater than the mean in asymptomatic patients sustained a fatal myelopathy, and in another, with an apparent antifolate half-life of 48 hours, irreversible neurologic sequelae developed. These observations suggest that the neurotoxicity associated with intrathecal methotrexate may be secondary to prolonged exposure to excessive drug concentrations in the central nervous system.
KW - Methotrexate--pharmacokinetics-;
KW - Pharmacokinetics--methotrexate--cerebrospinal fluid, of leukemia patients;
KW - Antineoplastic agents--methotrexate--pharmacokinetics, in cerebrospinal fluid of leukemia patients;
KW - Toxicity--methotrexate--neuro-, relation to elevated cerebrospinal fluid levels, of leukemia patients;
KW - Metabolism--methotrexate--pharmacokinetics, cerebrospinal fluid, of leukemia patients;
KW - Drugs, body distribution--methotrexate--pharmacokinetics, cerebrospinal fluid, of leukemia patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - JACOBS, LEON
T1 - NIH Grants and Contracts.
JO - Science
JF - Science
Y1 - 1973/10/12/
VL - 182
IS - 4108
M3 - Article
SP - 113
EP - 113
SN - 00368075
N1 - Accession Number: 85117416; JACOBS, LEON 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/12/1973, Vol. 182 Issue 4108, p113; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILLER, EPP A.
AU - GOLDMAN, PATRICIA S.
AU - ROSVOLD, H. ENGER
T1 - Delayed Recovery of Function following Orbital Prefontal Lesions in Infant Monkeys.
JO - Science
JF - Science
Y1 - 1973/10/19/
VL - 182
IS - 4109
M3 - Article
SP - 304
EP - 306
SN - 00368075
AB - Monkeys given orbital prefrontal lesions at 1, 4, or 8 weeks of age exhibited a severe learning disability when they were tested at 1 year of age, but showed substantial recovery by the time they were 2 years old. These results Suggest that the protracted maturation of intact cortical regions is important in recovery of function after early brain injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117491; MILLER, EPP A. 1; GOLDMAN, PATRICIA S. 1; ROSVOLD, H. ENGER 1; Affiliations: 1: Section on Neuropsychology, Laboratory of Psychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 10/19/1973, Vol. 182 Issue 4109, p304; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kattwinkel, J.;
AU - Taussig, L. M.;
AU - McIntosh, C. L.;
AU - di Sant'Agnese, P. A.;
AU - Boat, T. F.;
AU - \ET/;
T1 - Intrapleural instillation of quinacrine for recurrent pneumothorax. Use in a patient with cystic fibrosis
CT - Intrapleural instillation of quinacrine for recurrent pneumothorax. Use in a patient with cystic fibrosis
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/10/29/
VL - 226
IS - Oct 29
SP - 557
EP - 559
AD - Building 10, Room 8N-250, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-3016; Language: English; Chemical Name: Quinacrine--83-89-6; References: 12; Publication Type: Brief Reports; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Intrapleural instillation of quinacrine HCl was used to treat recurrent bilateral pneumothorax in a 29-year-old man with advanced pulmonary disease from cystic fibrosis. For 23 months and 11 months following intrapleural instillation of quinacrine into the left and right lungs, respectively, there was no recurrence of pneumothorax on either side. Death was due to pulmonary failure, and at autopsy there were dense adhesions completely obliterating the pleural spaces. This mode of therapy may provide a valuable alternative to surgery for the cystic fibrosis patient with severe lung disease and marginal pulmonary reserve.
KW - Quinacrine--pneumothorax-;
KW - Pneumothorax--quinacrine--therapy, by intrapleural instillation, in cystic fibrosis patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kleinman, L. M.;
AU - Tangrea, J. A.;
AU - Gallelli, J. F.;
AU - Brown, J. H.;
AU - Gross, E.;
T1 - Stability of solutions of essential amino acids
CT - Stability of solutions of essential amino acids
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1973/11/01/
VL - 30
IS - Nov
SP - 1054
EP - 1057
SN - 00029289
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-0252; Language: English; Chemical Name: Sodium bisulfite--7631-90-5 Tryptophan--73-22-3; References: 5; Publication Type: Assay and Quality Control; Journal Coden: AJHPA9; Section Heading: Pharmaceutics; Drug Analysis
N2 - A study was conducted to develop a stable solution of essential amino acids for parenteral nutrition. The procedure of mixing the amino acids to attain most rapid dissolution is presented. Chromatographic analysis of the original solution stored in clear glass vials showed tryptophan to be the only amino acid to decrease in quantity (10% degradation at both 25\DG/ C. at 6 months storage and 50\DG/ C. at 2 months storage). The addition of sodium bisulfite (0.1%) as an antioxidant caused a 25% decrease in tryptophan concentration in 4 hours at 25\DG/ C. Further chromatographic studies showed that sodium bisulfite reacts with tryptophan. Commercial amino acid solutions containing sodium bisulfite were also shown to have tryptophan degradation. Storage of the amino acid solution in amber vials resulted in a tryptophan concentration of 96% of original concentration after 6 months of storage at room temperature. It is recommended that solutions of essential amino acids be stored in amber vials at room temperature without sodium bisulfite with a 6-month expiration date.
KW - Sodium bisulfite--incompatibilities-;
KW - Tryptophan--incompatibilities-;
KW - Amino acids--stability--solutions, effects of mixing, storage and antioxidants;
KW - Stability--amino acids--solutions, effects of mixing, storage and antioxidants;
KW - Incompatibilities--sodium bisulfite and tryptophan--degradation, in amino acid solutions;
KW - Incompatibilities--tryptophan and sodium bisulfite--degradation, in amino acid solutions;
KW - Antioxidants--sodium bisulfite--incompatibilities, tryptophan, degradation, in amino acid solutions;
KW - Amino acids--tryptophan--incompatibilities, sodium bisulfite, degradation, in amino acid solutions;
KW - Storage--amino acids--solutions, effects on stability;
KW - Light--amino acids--solutions, effects on stability;
KW - Stability--sodium bisulfite--incompatibilities, tryptophan, in amino acid solution;
KW - Nutrition--amino acids--injections, amino acids, stability, effects of mixing, storage and antioxidants;
KW - Caloric agents--amino acids--hyperalimentation, injections, stability, effects of mixing, storage and antioxidants;
KW - Hyperalimentation--amino acids--injections, stability, effects of mixing, storage and antioxidants;
KW - Injections--amino acids--hyperalimentation, stability, effects of mixing, storage and antioxidants;
KW - Temperature--amino acids--solutions, effects on stability;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Balter, M. B.;
AU - Cisin, I. H.;
AU - Davidson, S. T.;
AU - Manheimer, D. I.;
AU - Mellinger, G. D.;
AU - \ET/;
T1 - Popular attitudes and beliefs about tranquilizers
CT - Popular attitudes and beliefs about tranquilizers
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/11/01/
VL - 130
IS - Nov
SP - 1246
EP - 1253
SN - 0002953X
AD - Box 5007, Berkeley, California 94715
AD - Institute for Research in Social Behavior, Berkeley, California; and Special Studies Section, Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
N1 - Accession Number: 11-3157; Language: English; References: 5; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2 - In a nation-wide survey of the extent and nature of psychotherapeutic drug use, respondents were questioned about their knowledge of tranquilizers and their attitudes toward the use of these drugs in general and in specific situations. Questions were designed to assess attitudes and beliefs concerning the use of tranquilizers, their effectiveness, the morality of using tranquilizers, their impact on mood and behavior, and short- and long-term physical effects and risks associated with their use. The data presented were obtained in personal interviews with 2,552 persons from 18 to 74 years of age.
KW - Psychotherapeutic agents--drug information--patients, use, attitudes, survey;
KW - Tranquilizers--drug information--patients, use, attitudes, survey;
KW - Drug information--psychotherapeutic agents--patients, use, attitudes, survey;
KW - Drug information--tranquilizers--patients, use, attitudes, survey;
KW - Patient information--psychotherapeutic agents--use, attitudes, survey;
KW - Patient information--tranquilizers--use, attitudes, survey;
KW - Rational therapy--psychotherapeutic agents--patients, use, attitudes, survey;
KW - Rational therapy--tranquilizers--patients, use, attitudes, survey;
KW - Sociology--psychotherapeutic agents--attitudes, survey of patients;
KW - Statistics--psychotherapeutic agents--use, survey of patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wyatt, R. J.;
AU - Kaplan, J.;
AU - Vaughan, T.;
T1 - Tolerance and dependence to serotonin
CT - Tolerance and dependence to serotonin
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/11/01/
VL - 29
IS - Nov
SP - 597
EP - 599
AD - Laboratory of Clinical Psychopharmacology, IRP National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, D.C. 20032
N1 - Accession Number: 12-0611; Language: English; Chemical Name: Carbidopa--38821-49-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents carbidopa and hydroxytryptophan (28:16); AHFS Class: Psychotherapeutic agents hydroxytryptophan and carbidopa; References: 19; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - In a trial of 11 phenothiazine-resistant chronic schizophrenic patients, 5-hydroxytryptophan (I) and carbidopa produced striking behavioral effects which were greatly diminished by gradual changes in I dosage. Dosage of I ranged up to 10 g./day while the dosage of carbidopa was maintained at 150 mg./day throughout the trial. It is speculated that tolerance and dependence developed to I administration in these patients and perhaps to serotonin itself. It is further speculated that rapid changes, even from normal serotonin concentration, might be responsible for many of the behavioral effects seen when the metabolism of serotonin is altered.
KW - Hydroxytryptophan--and carbidopa-;
KW - Carbidopa--and hydroxytryptophan-;
KW - Combined therapy--hydroxytryptophan and carbidopa--dosage, and behavioral effects, in schizophrenic patients;
KW - Combined therapy--carbidopa and hydroxytryptophan--dosage, and behavioral effects, in schizophrenic patients;
KW - Dosage--hydroxytryptophan and carbidopa--effects, behavioral, in schizophrenic patients;
KW - Dosage--carbidopa and hydroxytryptophan--effects, behavioral, in schizophrenic patients;
KW - Psychotherapeutic agents--carbidopa and hydroxytryptophan--dosage, and behavioral effects, in schizophrenic patients;
KW - Psychotherapeutic agents--hydroxytryptophan and carbidopa--dosage, and behavioral effects, in schizophrenic patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levis, W. R.;
AU - Kraemer, K. H.;
AU - Klingler, W. G.;
AU - Peck, G. L.;
AU - Terry, W. D.;
T1 - Topical immunotherapy of basal cell carcinomas with dinitrochlorobenzene
CT - Topical immunotherapy of basal cell carcinomas with dinitrochlorobenzene
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1973/11/01/
VL - 33
IS - Nov
SP - 3036
EP - 3042
SN - 00085472
AD - Dermatology and Immunology Branches, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-2629; Language: English; Chemical Name: Dinitrochlorobenzene--25567-67-3 Croton oil--8001-28-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents dinitrochlorobenzene (84:00); AHFS Class: Topical preparations dinitrochlorobenzene (10:00); AHFS Class: Antineoplastic agents croton oil (84:00); AHFS Class: Topical preparations croton oil; References: 16; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - One hundred thirteen tumors in 5 dinitrochlorobenzene (I)-sensitized patients with multiple basal cell carcinomas were treated with topical I. Thirty-six of the 113, or 32%, showed complete clinical regression, for periods of 5 to 18 months. An additional 29% showed partial regression. I induced only 15 to 25% complete regression in 4 of the 5 patients, whereas 21 of 30 basal cell carcinomas treated with I underwent complete regression in the 5th patient. In addition to variation of patient response, there was variation of response of tumors on the same patient. Photographic data presented separately are of a 6th patient with uncountable confluent basal cell carcinomas who responded well to I, but in whom accurate quantification on an individual tumor basis was not possible. Controls in this study included 63 untreated tumors that were adjacent to and distant from treated tumors. These control tumors showed no evidence of regression. Eleven tumors treated with inert vehicles did not respond. One subject with over 100 nodular basal cell carcinomas became tolerant to I and failed to respond to high concentrations of the drug. Croton oil caused complete regression in 6 of 26 treated tumors. The mechanism of I-induced regression of basal cell carcinoma remains unknown. The disappearance of locally invasive human cancer following the therapeutic imposition of a controlled allergic contact dermatitis provides a useful model for the study of immunotherapy of cancer in humans.
KW - Dinitrochlorobenzene--carcinomas-;
KW - Croton oil--carcinomas-;
KW - Antineoplastic agents--dinitrochlorobenzene--carcinomas, basal cell, topical therapy, in patients;
KW - Topical preparations--dinitrochlorobenzene--carcinomas, basal cell, therapy, in patients;
KW - Antineoplastic agents--croton oil--carcinomas, basal cell, topical therapy, in patients;
KW - Topical preparations--croton oil--carcinomas, basal cell, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cohen, B. E.;
AU - Cohen, I. K.;
T1 - Vitamin A: adjuvant and steroid antagonist in the immune response
CT - Vitamin A: adjuvant and steroid antagonist in the immune response
JO - J. Immunol.
JF - J. Immunol.
Y1 - 1973/11/01/
VL - 111
IS - Nov
SP - 1376
EP - 1380
AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland
N1 - Accession Number: 11-1705; Language: English; Chemical Name: Vitamin A--11103-57-4 Hydrocortisone--50-23-7; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2 - The effects of vitamin A and hydrocortisone on the immune response have been studied in the mouse. Vitamin A treatment alone markedly increases the normal number of antibody forming cells generated in the spleen in response to immunization with sheep red blood cells. The antibody response to immunization with dinitrophenylated ovalbumin, a haptenprotein conjugate, is also enhanced by vitamin A pretreatment. Furthermore, the immunosuppressive effect of hydrocortisone on the response to sheep red blood cells can be prevented by simultaneous administration of vitamin A.
KW - Vitamin A--effects-;
KW - Hydrocortisone--immunosuppression-;
KW - Steroids, cortico---hydrocortisone--immunosuppression, prevention by simultaneous administration of vitamin A, in mice;
KW - Drug interactions--hydrocortisone and vitamin A--inhibition, immunosuppression, in mice;
KW - Drug interactions--vitamin A and hydrocortisone--inhibition, immunosuppression, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yeh, S. Y.;
T1 - Separation and identification of morphine and its metabolites and congeners
CT - Separation and identification of morphine and its metabolites and congeners
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/11/01/
VL - 62
IS - Nov
SP - 1827
EP - 1829
SN - 00223549
AD - Addiction Research Center, National Institute of Mental Health, Lexington, Kentucky 40507
N1 - Accession Number: 12-1962; Language: English; Chemical Name: Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 26; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Morphine and its known and postulated metabolites and congeners, i.e., morphine N-oxide, normorphine, pseudomorphine, morphine-N-methyl iodide, codeine, norcodeine, morphine-3-glucuronide, and morphine ethereal sulfate, were separated by TLC and GLC.
KW - Morphine--chromatography, gas-;
KW - Chromatography, gas--morphine--and TLC, separation from metabolites and congeners;
KW - Chromatography, thin layer--morphine--and chromatography, gas, separation from metabolites and congeners;
KW - Analgesics and antipyretics--morphine--chromatography, gas, and TLC, separation from metabolites and congeners;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Williams Jr., Redford B.
AU - Frankel, Bernard L.
AU - Galin, J. Christian
AU - Weiss, James L.
T1 - Cardiovascular Response During a Word Association Test and an Interview.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1973/11//
VL - 10
IS - 6
M3 - Article
SP - 571
EP - 577
SN - 00485772
AB - Previous work has demonstrated a consistent increase in diastolic blood pressure during an interview relative to a word association test. A consideration of normal cardiovascular mechanisms suggests that such increased diastolic pressure could be associated with decreased forearm blood flow. This expectation is at variance with previous studied in which psychological stimuli have been associated only with increased forearm blood flow. Forearm blood flow and pulse rate were measured during rest periods and during a word association test and an interview in 8 normal volunteers and 8 psychiatric inpatients. Twelve of the 16 Ss showed a decrease in forearm blood flow during the interview, thus confirming our expectation. That this decrease is an active response, rather than a passive fall, is suggested by the finding of increased heart rate during the interview. The cardiovascular responses of the patient group differed in some respects form those of the normal group. We hypothesize that the attentional deficit of the schizophrenics in the patients sample may have contributed to this difference. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD pressure
KW - CARDIOVASCULAR system
KW - BLOOD flow
KW - SCHIZOPHRENIA
KW - PSYCHOSES
KW - HEART beat
KW - Forearm blood flow
KW - Heart rate
KW - Interview psychophysiology.
N1 - Accession Number: 11728898; Williams Jr., Redford B. 1 Frankel, Bernard L. 1 Galin, J. Christian 1 Weiss, James L. 1; Affiliation: 1: Laboratory of Clinical Psychobiology, Laboratory of Clinical Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health.; Source Info: Nov1973, Vol. 10 Issue 6, p571; Subject Term: BLOOD pressure; Subject Term: CARDIOVASCULAR system; Subject Term: BLOOD flow; Subject Term: SCHIZOPHRENIA; Subject Term: PSYCHOSES; Subject Term: HEART beat; Author-Supplied Keyword: Forearm blood flow; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Interview psychophysiology.; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1469-8986.ep11728898
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-16484-020
AN - 2005-16484-020
AU - Shore, Milton F.
AU - Jones, Robert E.
ED - Shore, Milton F.
T1 - Psychological Research on Drug Addicts.
JF - Professional Psychology
JO - Professional Psychology
JA - Prof Psychol
Y1 - 1973/11//
VL - 4
IS - 4
SP - 468
EP - 474
CY - US
PB - American Psychological Association
SN - 0033-0175
N1 - Accession Number: 2005-16484-020. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Addiction; Experimentation; Treatment. Classification: Substance Abuse & Addiction (3233). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Nov, 1973. Copyright Statement: American Psychological Association. 1973.
AB - At the Addiction Research Center at Lexington, NIMH has for over two decades been actively researching narcotic drugs and their antagonists, but the Clinical Research Center's mission is oriented toward characteristics of drug abusers and their psychosocial treatment, not toward the characteristics of narcotic agents and their antagonists or less noxious substitutes. The Lexington Center has exchanged research information with other federal agencies concerned with drug addiction and with many of the larger state and community programs. This 'progress' report is intended mainly to establish communication with psychologists who are working in settings partly but not exclusively concerned with the prevention, treatment, or rehabilitation of drug addicts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological research
KW - drug addicts
KW - psychosocial treatment
KW - characteristics of drug abusers
KW - 1973
KW - Drug Abuse
KW - Drug Addiction
KW - Experimentation
KW - Treatment
KW - 1973
DO - 10.1037/h0021450
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06244-021
AN - 2006-06244-021
AU - Caron, Albert J.
T1 - Child Development à la Russe.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1973/11//
VL - 18
IS - 11
SP - 539
EP - 540
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06244-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Caron, Albert J.; National Institute of Mental Health, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Developmental Psychology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Zaporozhets, A. V.; Elkonin, D. B. The Psychology of Preschool Children=Cambridge, Mass.: MIT Press, 1971. Pp. xxiii + 376. $12.50; 1971. Page Count: 2. Issue Publication Date: Nov, 1973.
AB - Reviews the book, The Psychology of Preschool Children by A. V. Zaporozhets and D. B. Elkonin (see record [rid]1972-10572-000[/rid]). This book constitutes the standard Soviet reference on research in early child development and is widely used as a text in universities and pedagogical institutes throughout the Soviet Union. In sum, this book provides a picture of Soviet developmental psychology. It portrays a discipline still trying to gain an objective scientific foothold within the limited confines of official doctrine. Given this constraint, as well as the prolonged isolation of Soviet psychology from the international scientific community, the slenderness of the achievement is not to be gainsaid. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child development
KW - developmental psychology
KW - preschool children
KW - Soviet psychology
KW - 1973
KW - Childhood Development
KW - Developmental Psychology
KW - 1973
U2 - Zaporozhets, A. V.; Elkonin, D. B. (1971); The Psychology of Preschool Children; Cambridge, Mass.: MIT Press, 1971. Pp. xxiii + 376. $12.50
DO - 10.1037/0011733
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - PARLOFF, MORRIS B.
T1 - A Psychodiagnostic Instrument.
JO - Science
JF - Science
Y1 - 1973/11/09/
VL - 182
IS - 4112
M3 - Article
SP - 574
EP - 575
SN - 00368075
N1 - Accession Number: 85117554; PARLOFF, MORRIS B. 1; Affiliations: 1: Clinical Research Branch, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p574; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GILLER JR., EARL L.
AU - SCHRIER, BRUCE K.
AU - SHAINBERG, ASHER
AU - FISK, H. RONALD
AU - NELSON, PHILLIP G.
T1 - Choline Acetyltransferase Activity Is Increased in Combined Cultures of Spinal Cord and Muscle Cells from Mice.
JO - Science
JF - Science
Y1 - 1973/11/09/
VL - 182
IS - 4112
M3 - Article
SP - 588
EP - 589
SN - 00368075
AB - The activity of choline acetyltransferase was more than tenfold greater in combined cultures of spinal cord and muscle cells than in cultures of spinal cord cells alone. This increase was associated with the formation of functional neuromuscular junctions in culture. Counts of silver-stained cells and determinations of other enzyme activities indicated that the increased choline acetyltransferase activity was not due to nonspecific neuronal survival but reflected greater activity in the surviving neurons. Hence, muscle had a marked, highly specific trophic effect on the cholinergic neurons that innervated it. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117563; GILLER JR., EARL L. 1; SCHRIER, BRUCE K. 1; SHAINBERG, ASHER 1; FISK, H. RONALD 1; NELSON, PHILLIP G. 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p588; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - POTTER, MICHAEL
AU - SKLAR, MARSHALL D.
AU - ROWE, WALLACE P.
T1 - Rapid Viral Induction of Plasmacytomas in Pristane-Primed BALB/c Mice.
JO - Science
JF - Science
Y1 - 1973/11/09/
VL - 182
IS - 4112
M3 - Article
SP - 592
EP - 594
SN - 00368075
AB - Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin- producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117565; POTTER, MICHAEL 1; SKLAR, MARSHALL D. 2; ROWE, WALLACE P. 2; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Issue Info: 11/ 9/1973, Vol. 182 Issue 4112, p592; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOLLINSHEAD, ARIEL C.
AU - OBONG LEE
AU - CHRETIEN, PAUL B.
AU - TARPLEY, JOHN L.
AU - RAWLS, WILLIAM E.
AU - ADAM, ERVIN
T1 - Antibodies to Herpesvirus Nonvirion Antigens in Squamous Carcinomas.
JO - Science
JF - Science
Y1 - 1973/11/16/
VL - 182
IS - 4113
M3 - Article
SP - 713
EP - 715
SN - 00368075
AB - Serums from tumor-bearing patients, cured patients, and normal subjects were examined for antibodies to the separated complement-fixing reactive components of nonvirion antigens of herpesvirus type 1 and type 2. The occurrence of antibodies to the antigens was similar in serums from tumor-bearing patients and cured patients. Antibodies to the antigens were observed among 21 of 24 (87 percent) cervical cancer cases, 44 of 49 (90 percent) laryngeal cancer cases, 15 of 24 (62 percent) cases of squamous cell carcinomas of the head and neck excluding the larynx, 2 of 24 (8 percent) nonsquamous cell cancer cases, and 3 of 51 (6 percent) normal subjects. By contrast, no differences were found in the titers of neutralizing antibodies to the virus in serums from laryngeal cancer patients and controls. The observations support an etiologic role of herpesviruses in cervical cancer and in laryngeal cancer, and possibly other squamous cell cancers of the head and neck. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117606; HOLLINSHEAD, ARIEL C. 1; OBONG LEE 1; CHRETIEN, PAUL B. 2; TARPLEY, JOHN L. 2; RAWLS, WILLIAM E. 3; ADAM, ERVIN 3; Affiliations: 1: Laboratory for Virus and Cancer Research, Department of Medicine, George Washington University, Washington, D.C. 20037; 2: Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Departments of Virology and Epidemiology, Baylor University College of Medicine, Texas Medical Center, Houston 77025; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p713; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - GANER, HAROLD
T1 - Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials.
JO - Science
JF - Science
Y1 - 1973/11/16/
VL - 182
IS - 4113
M3 - Article
SP - 720
EP - 722
SN - 00368075
AB - The effects of pentobarbital (Nembutal) on synaptic transmission and postsynaptic potentials were studied by the use of several invertebrate preparations. Pentobarbital selectively and reversibly depressed both excitatory postsynaptic potentials and sodium-dependent postsynaptic responses to putative excitatory transmitters without affecting either inhibitory postsynaptic potentials or chlorideand potassium-dependent postsynaptic responses to putative transmitters. A selective depression of postsynaptic excitatory events was also observed with other central nervous system depressants (ethanol, chloroform, chloralose, diphenylhydantoin, and urethane). The results suggest that central and peripheral depression observed during general anesthesia is due to a selective depression of excitatory synaptic events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117609; BARKER, JEFFERY L. 1; GANER, HAROLD 1; Affiliations: 1: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p720; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SPORN, MICHAEL B.
AU - DUNLOP, NANCY M.
AU - YUSPA, STUART H.
T1 - Retinyl Acetate: Effect on Cellular Content of RNA in Epidermis in Cell Culture in Chemically Defined Medium.
JO - Science
JF - Science
Y1 - 1973/11/16/
VL - 182
IS - 4113
M3 - Article
SP - 722
EP - 723
SN - 00368075
AB - Cell cultures of epidermis from newborn mice were established in chemically defined medium. Additions of retinyl acetate to these cultures caused a significant increase in cellular RNA content. Addition of insulin and hydrocortisone to the cultures potentiated the eflect of retinyl acetate on cellular RNA content. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117610; SPORN, MICHAEL B.; DUNLOP, NANCY M.; YUSPA, STUART H. 1; Affiliations: 1: Experimental Pathology Branch, Carcinogenesis Program, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/16/1973, Vol. 182 Issue 4113, p722; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TULLY, J. G.
AU - WHITCOMB, R. F.
AU - BOVE, J. M.
AU - SAGLIO, P.
T1 - Plant Mycoplasmas: Serological Relation between Agents Associated with Citrus Stubborn and Corn Stunt Diseases.
JO - Science
JF - Science
Y1 - 1973/11/23/
VL - 182
IS - 4114
M3 - Article
SP - 827
EP - 829
SN - 00368075
AB - Growth-inhibition and precipitin tests established that antigens of the helical iniycoplasmtia-like organism (Spiroplasma citri) associated with citrus stubborn disease are serologically related to antigens in corn infected with stunt disease but not in healthy corn. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436975; TULLY, J. G. 1; WHITCOMB, R. F. 2; BOVE, J. M. 3; SAGLIO, P. 3; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Plant Protection Institute, U.S. Department of Agriculture, Beltsville, Maryland 20705; 3: Station de Physiologie et de Biochitnie Vegetales, Centre de Recherches de Bordeaucx, Institut National le la Recherche Agronomzique, 33 Pont-de-la-Maye, France; Issue Info: 11/23/1973, Vol. 182 Issue 4114, p827; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GORDEN, P.
AU - LESNIAK, M. A.
AU - HENDRICKS, C. M.
AU - ROTH, J.
T1 - "Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay.
JO - Science
JF - Science
Y1 - 1973/11/23/
VL - 182
IS - 4114
M3 - Article
SP - 829
EP - 831
SN - 00368075
AB - Plasma as well as pituitary itninunoreactive human growth hormone (HGH) comprises at least two discrete comlponents which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to coinpete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component fromz both normnal and acroinegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH comnponient has simnilar activity in both assays. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436936; GORDEN, P. 1; LESNIAK, M. A. 1; HENDRICKS, C. M. 1; ROTH, J. 1; Affiliations: 1: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/23/1973, Vol. 182 Issue 4114, p829; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Stephens, R. C.;
AU - Weppner, R. S.;
T1 - Legal and illegal use of methadone: one year later
CT - Legal and illegal use of methadone: one year later
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1973/12/01/
VL - 130
IS - Dec
SP - 1391
EP - 1394
SN - 0002953X
AD - Reprints: New York State Narcotic Addiction Control Commission, 1855 Broadway, New York, New York 10023
AD - National Institute of Mental Health Clinical Research Center, Lexington, Kentucky
N1 - Accession Number: 11-3858; Language: English; Chemical Name: Methadone--76-99-3; References: 1; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2 - The results of a study which shows that the use of methadone, both legal and illegal, has increased are discussed. In a sample of 469 newly admitted narcotic addicts, 75% had experience with methadone and 52% had used it illegally. Compared to a previous study, the role of the pusher as a supplier of illicit methadone has declined while other suppliers have become more important. The low cost of methadone and its ease of procurement are suggested as reasons for the increase in its illegal use.
KW - Methadone--abuse-;
KW - Drug abuse--methadone--and legal use, discussion, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Buchsbaum, M.;
AU - Wender, P.;
T1 - Average evoked responses in normal and minimally brain dysfunctioned children treated with amphetamine
CT - Average evoked responses in normal and minimally brain dysfunctioned children treated with amphetamine
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1973/12/01/
VL - 29
IS - Dec
SP - 764
EP - 770
AD - National Institute of Mental Health, Building 10, Room 2N-315, Bethesda, Maryland 20014
N1 - Accession Number: 11-4865; Language: English; Chemical Name: Amphetamine--300-62-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine; References: 25; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Visual and auditory average evoked responses in 24 minimal brain dysfunction children, 6 to 12 years old, were considered immature when compared to responses seen in 48 normal children; amphetamine effects on these responses was studied. Minimal brain dysfunction children who received amphetamine, 10 to 20 mg./day, and showed clinical improvement tended to display immature response patterns off drug to a greater extent than minimally brain dysfunction amphetamine nonresponders.
KW - Amphetamine--minimal brain dysfunction-;
KW - Central nervous system stimulants--amphetamine--minimal brain dysfunction, therapy, immature average evoked responses, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Horowitz, Herschel S.
T1 - A review of systemic and topical fluorides for the prevention of dental caries.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1973/12//
VL - 1
IS - 3
M3 - Article
SP - 104
EP - 114
SN - 03015661
AB - Because community fluoridation constitutes nearly an ideal public health method, it should be the cornerstone of all national programs of dental caries prevention. Where fluoridation is not possible for technical or political reasons, some alternative methods of providing benefits from systemic fluorides are available, including school water fluoridation, dietary supplements of fluoride and the fluoridation of salt. Dietary supplements of fluoride are not recommended for pregnant women for caries protection in their offspring. In areas with low fluoride levels in drinking water, solutions of 2 % sodium fluoride, 8% stannous fluoride and acidulated phosphate-fluoride (APF) (1.2 % F ion) and the same concentration of an APF gel applied professionally can prevent dental caries. APF is currently the choice for these applications. Fluoride prophylaxis pastes should be used, particularly when a topical fluoride application is not scheduled to follow the prophylaxis. Effective unsupervised topical fluoride applications occur with use of fluoride containing dentifrices. Supervised self-applications of fluoride for public health programs overcome the inefficiencies of individual professional applications. Many studies continue to be reported on mouth-rinsing with fluoride solutions, toothbrushing with fluoride solutions and gels, toothbrushing with fluoride prophylaxis pastes and the application of fluoride gels in mouthpieces. Fluoride mouth-rinsing has several advantages. Self-application of fluorides will undoubtedly become the method of choice for delivering topical fluorides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries
KW - DENTAL pathology
KW - FLUORIDES
KW - ORAL hygiene products
KW - DENTISTRY
KW - PUBLIC health
KW - dental
KW - dental caries
KW - fluorides
KW - prevention
N1 - Accession Number: 12088111; Horowitz, Herschel S. 1; Affiliation: 1: National Institute of Dental Research, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Maryland, U.S.A.; Source Info: Dec1973, Vol. 1 Issue 3, p104; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: FLUORIDES; Subject Term: ORAL hygiene products; Subject Term: DENTISTRY; Subject Term: PUBLIC health; Author-Supplied Keyword: dental; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: fluorides; Author-Supplied Keyword: prevention; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1600-0528.ep12088111
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schein, Philip S.
T1 - Chemotherapy in advanced ovarian cancer.
JO - Geriatrics
JF - Geriatrics
Y1 - 1973/12//
VL - 28
IS - 12
M3 - Article
SP - 89
EP - 95
SN - 0016867X
N1 - Accession Number: 17524996; Schein, Philip S. 1; Source Information: Dec1973, Vol. 28 Issue 12, p89; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3239
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Carlson, Rae
AU - Levy, Nissim
T1 - Studies of Jungian typology: I. Memory, social perception, and social action.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1973/12//
VL - 41
IS - 4
M3 - Article
SP - 559
EP - 576
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 9027624; Carlson, Rae 1 Levy, Nissim 2; Affiliation: 1: National Institute of Mental Health. 2: Howard University.; Source Info: Dec73, Vol. 41 Issue 4, p559; Number of Pages: 18p; Document Type: Article
L3 - 10.1111/1467-6494.ep9027624
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ellenberg, Jonas H.
T1 - The Joint Distribution of the Standardized Least Squares Residuals from a General Linear Regression.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1973/12//
VL - 68
IS - 344
M3 - Article
SP - 941
SN - 01621459
AB - In this article the p-variate joint distribution is derived for a subset of p of the n standardized least squares residuals from a general linear regression. The resulting distribution is a standardized version of the Inverted-Student Function [8, p. 259]. An application of this result to the problem of detection of outliers is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - REGRESSION analysis
KW - ESTIMATION theory
KW - MATHEMATICAL statistics
KW - PROBABILITY theory
KW - LEAST squares
N1 - Accession Number: 4603783; Ellenberg, Jonas H. 1; Affiliations: 1: Head, Section on Experimental Statistics, Office of Biometry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md. 20014.; Issue Info: Dec73, Vol. 68 Issue 344, p941; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: REGRESSION analysis; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Subject Term: LEAST squares; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Rosenberg, E.;
AU - Powell, R.;
T1 - Active tumor immunotherapy with BCG
CT - Active tumor immunotherapy with BCG
JO - South Med. J.
JF - South Med. J.
Y1 - 1973/12/01/
VL - 66
IS - Dec
SP - 1359
EP - 1363
AD - Reprints: Division of Nuclear Medicine and Oncology, University of Miami School of Medicine, Miami, Florida 33152
AD - Immunology Branch and Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-2982; Language: English; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; References: 20; Journal Coden: SMJOAV; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Tim R. Covington
N2 - One patient with widely metastatic carcinoma of the breast was treated with BCG injected into subcutaneous tumor nodules in an effort to produce a significant clinical remission. Selected subcutaneous nodules of the anterior chest were injected with 0.1 ml. of freshly suspended BCG in an effort to boost the immune response. Injected tumor nodules showed an intense inflammatory reaction and a marked decrease in tumor cells. All injected nodules involuted within 2 months. The use of BCG did not, however, check the overall progression of the disease as the number of subcutaneous nodules continued to increase and a cervical node enlarged. Although BCG immunotherapy has been effective in various neoplasma of animals and man, it was not clinically effective in this patient.
KW - BCG vaccines--carcinomas-;
KW - Immunosuppressive agents--BCG vaccines--carcinomas, breast, lack, effects, on remission, case report;
KW - Drug administration--routes--BCG vaccines, injections into S.C. nodules, breast cancer therapy, case report;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - FEINSTONE, STEPHEN M.
AU - KAPIKIAN, ALBERT Z.
AU - PURCELI, ROBERT H.
T1 - Hepatitis A: Detection by Immune Electron Microscopy of a Viruslike Antigen Associated with Acute Illness.
JO - Science
JF - Science
Y1 - 1973/12/07/
VL - 182
IS - 4116
M3 - Article
SP - 1026
EP - 1028
SN - 00368075
AB - Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178809; FEINSTONE, STEPHEN M. 1; KAPIKIAN, ALBERT Z. 1; PURCELI, ROBERT H. 1; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/ 7/1973, Vol. 182 Issue 4116, p1026; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ALLEN, GORDON
AU - PETTIGREW, KAREN D.
AU - ERLENMEYER-KIMLING, L.
AU - STERN, SAMUEL E.
AU - SCARR-SALAPATEK, SANDRA
T1 - Heritability of IQ by Social Class: Evidence Inconclusive.
JO - Science
JF - Science
Y1 - 1973/12/07/
VL - 182
IS - 4116
M3 - Article
SP - 1042
EP - 1047
SN - 00368075
N1 - Accession Number: 85178816; ALLEN, GORDON 1; PETTIGREW, KAREN D. 2; ERLENMEYER-KIMLING, L. 3; STERN, SAMUEL E. 4; SCARR-SALAPATEK, SANDRA 5; Affiliations: 1: Mental Health Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Biometry Branch, National Institute of Mental Health; 3: Department of Medical Genetics, New York State Psychiatric Institute, New York 10032; 4: Department of Sociology, Georgia State University, Atlanta 30303; 5: Institute of Child Development, University of Minnesota, Minneapolis 55455; Issue Info: 12/ 7/1973, Vol. 182 Issue 4116, p1042; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Carman, J. S.;
AU - Tucker, L. S.;
T1 - Benztropine in childhood hyperkinesis
CT - Benztropine in childhood hyperkinesis
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/12/08/
VL - 2
IS - Dec 8
SP - 1337
EP - 1338
SN - 00237507
AD - National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-2217; Language: English; Chemical Name: Benztropine--86-13-5; References: 9; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2 - Suppression of the aggressive, antisocial component of the hyperkinetic syndrome in children with benztropine and possible mechanisms of action are discussed.
KW - Benztropine--hyperkinesis-;
KW - Hyperkinesis--benztropine--effects, on aggressive, antisocial behavior, in children;
KW - Mechanism of action--benztropine--hyperkinesis, effects on aggressive, antisocial behavior, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PERTEL, RUTH
T1 - Host-Finding Strategies.
JO - Science
JF - Science
Y1 - 1973/12/14/
VL - 182
IS - 4117
M3 - Article
SP - 1124
EP - 1125
SN - 00368075
N1 - Accession Number: 85178837; PERTEL, RUTH 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; Issue Info: 12/14/1973, Vol. 182 Issue 4117, p1124; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DVORNIK, D.
AU - SIMARD-DUQUESNE, N.
AU - KRAMI, M.
AU - SESTANJ, K.
AU - GABBAY, K. H.
AU - KINOSHITA, J. H.
AU - VARMA, S. D.
AU - MEROLA, L. O.
T1 - Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor.
JO - Science
JF - Science
Y1 - 1973/12/14/
VL - 182
IS - 4117
M3 - Article
SP - 1146
EP - 1148
SN - 00368075
AB - An orally active inhibitor of aldose redlictase, 1,3-dioxo-1H-benz[de]- isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concenttrations of galactose. When given orally, A Y-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactoseiniic rats with AY-22,284 effectively suppressed the formnation of cataracts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178849; DVORNIK, D. 1; SIMARD-DUQUESNE, N. 1; KRAMI, M. 1; SESTANJ, K. 1; GABBAY, K. H. 2; KINOSHITA, J. H. 3; VARMA, S. D. 3; MEROLA, L. O. 3; Affiliations: 1: Department of Biochemistry, Ayerst Research Laboratories, Montreal, Quiebec, Canada; 2: Cell Biology, Laboratory, Endocrine Division, Children's Hospital Medical Centter, Boston, Massachusetts 02115, and Department of Pediatrics, Harvard Medical School, Boston; 3: Laboratory of Vision Research, National Eye Institute, Bethescda, Maryland 20015; Issue Info: 12/14/1973, Vol. 182 Issue 4117, p1146; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WHITCOMB, R. F.
AU - TULLY, J. G.
AU - BOVÉ, J. M.
AU - SAGLIO, P.
T1 - Spiroplasmas and Acholeplasmas: Multiplication in Insects.
JO - Science
JF - Science
Y1 - 1973/12/21/
VL - 182
IS - 4118
M3 - Article
SP - 1251
EP - 1253
SN - 00368075
AB - The helical wall-free microorganism, Spiroplasma citri, which is associated with citrus stubborn, a disease with no known vector, multiplied in the leafhopper vector of corn stunt but multiplied to higher titer in the vector of aster yellows and decreased the longevity of that insect. Acholeplasma laidlawii and A. granularum also multiplied in both leafhoppers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178888; WHITCOMB, R. F. 1; TULLY, J. G. 2; BOVÉ, J. M. 3; SAGLIO, P. 3; Affiliations: 1: U.S. Department of Agriculture, Agricultural Research Service, Plant Protection Institute, Beltsville, Maryland 20705; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 3: Station de Physiologie et de Biochimie Végétales, Centre de Recherches de Bordeaux, Institut National de la Recherche Argonomique, 33, Pont-de-le Maye, France; Issue Info: 12/21/1973, Vol. 182 Issue 4118, p1251; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CARPENTER JR., WILLIAM T.
AU - STRAUSS, JOHN S.
AU - BARTKO, JOHN J.
T1 - Flexible System for the Diagnosis of Schizophrenia: Report from the WHO International Pilot Study of Schizophrenia.
JO - Science
JF - Science
Y1 - 1973/12/21/
VL - 182
IS - 4118
M3 - Article
SP - 1275
EP - 1278
SN - 00368075
AB - Behavioral data on a large patient group were collected by investigators from nine countries in the International Pilot Study of Schizophrenia, sponsored by the World Health Organization. The data on half the group were analyzed to derive a system of 12 signs and symptoms for the identification of schizophrenia, as this disorder is diagnosed in many centers throughout the world. The findings were replicated with the other half of the patient group. The criteria constitute an operational method for identifying patients who would be commonly considered schizophrenic in many centers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178900; CARPENTER JR., WILLIAM T. 1; STRAUSS, JOHN S. 2; BARTKO, JOHN J. 3; Affiliations: 1: Psychiatric Assessment Section, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14620; 3: Biometry Branch, National Institute of Mental Health; Issue Info: 12/21/1973, Vol. 182 Issue 4118, p1275; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-06011-000
AN - 9999-06011-000
AU - Derogatis, Leonard R.
AU - Lipman, Ronald S.
AU - Rickels, Karl
AU - Uhlenhuth, E. H.
AU - Covi, Lino
T1 - Hopkins Symptom Checklist
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1974///
AD - Derogatis, Leonard R., Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States, 21205
AV - Commercial: No; Permissions: Not Specified; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-06011-000. Acronyms: HSCL. Partial author list: First Author & Affiliation: Derogatis, Leonard R.; Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States. Release Date: 20130211. Correction Date: 20160711. Instrument Type: Checklist. Test Format: Participants rate their level of distress on each item on a 4-point Likert-type scale from 1 'not at all' to 4 'extreme.'. Language: English. Constructs: Psychological Distress Symptoms; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10).
N2 - Administration Method: Paper
AB - Purpose: The Hopkins Symptom Checklist is a self-report psychological symptom inventory.
AB - Description: The Hopkins Symptom Checklist (HSCL; Derogatis et al, 1974) is a self-report symptom inventory. The HSCL is comprised of 58 items which are representative of the symptom configurations commonly observed among outpatients. It is scored on five underlying symptom dimensions-somatization, obsessive-compulsive, interpersonal sensitivity, anxiety and depression--which have been identified in repeated factor analyses. A series of studies have established the factorial invariance of the primary symptom dimensions, and substantial evidence is given in support of their construct validity. Normative data in terms of both discrete symptoms and primary symptom dimensions are from 2,500 subjects (800 psychiatric outpatients and 700 normal individuals). Indices of pathology reflect both intensity of distress and prevalence of symptoms in the normative samples. A series of studies have established the factorial invariance of the primary symptom dimensions, and substantial evidence is given in support of their construct validity. The evolution and development of the instrument has not permanently crystallized with the 58-item HSCL. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Hopkins Symptom Checklist
KW - Psychological Assessment
KW - Psychological Symptoms
KW - Self Report
KW - Test Development
U5 - Hopkins Symptom Checklist (HSCL) [Test Development]The Hopkins Symptom Checklist (HSCL): A self-report symptom inventory. (AN: 1974-21363-001 from PsycINFO) Derogatis, Leonard R.; Lipman, Ronald S.; Rickels, Karl; Uhlenhuth, E. H.; Covi, Lino; Jan, 1974. Source: Behavioral Science. 19(1), General Systems Science Foundation, US; Jan, 1974; Administration: Paper Population: Human; Samples: Psychiatric Outpatients and Inpatients Keywords: Hopkins Symptom Checklist; Psychological Assessment; Psychological Symptoms; Self Report; Test Development; Subjects: Checklist (Testing); Psychiatric Symptoms; Psychological Assessment; Self-Report; Symptom Checklists; Test Construction;
DO - 10.1037/t06011-000
L3 - Full; Full text; 999906011_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-15303-000
AN - 9999-15303-000
AU - Beck, Aaron T.
AU - Resnik, Aaron T.
AU - Lettieri, Dan J.
T1 - Suicide Intent Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1974///
AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1 - Accession Number: 9999-15303-000. Other Names: Suicidal Intent Scale; Suicide Intent Scales. Acronyms: SIS. Partial author list: First Author & Affiliation: Beck, Aaron T.; University of Pennsylvania, Philadelphia, Pennsylvania, United States. Release Date: 20140113. Correction Date: 20151207. Instrument Type: Rating Scale. Test Location: Table 3-2, Page 54. Test Format: The items on the Suicide Intent Scale are either forced-choice responses, or consist of three alternative statements graded in intensity from 0 to 2.. Language: English. Constructs: Suicidal Intent; Classification: Emotional States, Emotional Responses, and Motivation (6000). Population: Human (10); Male (30); Female (40). Other Versions: 9999-44545-000, Suicide Intent Scale--Chinese Version, Translation.
N2 - Administration Method: Interview
AB - Purpose: The purpose of the Suicide Intent Scale is to record data regarding the intensity of the attempter's wish to die at the time of the attempt.
AB - Description: The Suicide Intent Scale (SIS; Beck, Resnick, & Lettieri, 1974) is a 20-item scale designed to record data regarding the intensity of the attempter's wish to die at the time of the attempt. In order to assess this expectancy, the scale is completed on the basis of retrospective data obtained from the patient and relevant observers, such as family and police. The scale is divided into three sections. Each item consists of three alternative statements graded in intensity from 0 to 2. The total score consists of the summed scores for each item. The first section, Circumstances Related to Suicidal Attempt, deals mainly with factual aspects of the attempt and the events surrounding it. The second section, Self Report, is used to record retrospectively the patient's thoughts and feelings at the time of the attempt. The third section is unscored, since the weighting of the alternatives is uncertain at this time. Following an intake interview, each interviewer independently completes the scale. The total intent score for each case is computed. The coefficient in 45 cases was found to have been r = .95 (inter-rater reliability). After correction for attenuation (Spearman Brown), the correlation coefficient was .82 (internal consistency). (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Interrater Reliability
KW - Test Development
KW - Suicide Intent Scale
KW - Internal Consistency
U5 - Suicide Intent Scale (SIS) [Test Development]Development of suicidal intent scales. (AN: 1975-05602-003 from PsycINFO) Beck, Aaron T.; Schuyler, Dean; Herman, Ira; 1974. Source: The prediction of suicide., Beck, Aaron T.; Resnik, Harvey L.; Lettieri, Dan J.; Charles Press Publishers, Oxford, England; Administration: Interview Population: Human; Male; Female; Sample: Suicidal Patients; Location: United States Keywords: Interrater Reliability; Test Development; Suicide Intent Scale; Internal Consistency; Subjects: Interrater Reliability; Rating Scales; Suicidal Ideation; Test Construction; Test Reliability;
DO - 10.1037/t15303-000
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
TY - GEN
AU - Seamen, W. E.;
AU - Ishak, K. G.;
AU - Plotz, P. H.;
T1 - Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus
CT - Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1974/01/01/
VL - 80
IS - Jan
SP - 1
EP - 8
SN - 00034819
AD - Arthritis and Rheumatology Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; and Hepatic and Pediatric Pathology Branch, Armed Forces Institute of Pathology, Washington, D.C.
N1 - Accession Number: 11-3906; Language: English; Chemical Name: Aspirin--50-78-2; References: 46; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity
N2 - Three patients with systemic lupus erythematosus were noted to have evidence of liver injury that proved to be related to aspirin therapy. In 2 of the patients, the initial presentation mimicked chronic active hepatitis. A liver biopsy obtained from one of the patients was also consistent with the diagnosis of chronic active hepatitis, and the biopsy from a second patient showed acute hepatocellular injury. Aspirin should be considered among causes of hepatitis, particularly in patients with lupus erythematosus.
KW - Aspirin--toxicity-;
KW - Toxicity--aspirin--hepatitis, in systemic lupus erythematosus patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Raskin, A.;
AU - Schulterbrandt, J. B.;
AU - Reatig, N.;
AU - Crook, T. H.;
AU - Odle, D.;
T1 - Depression subtypes and response to phenelzine, diazepam, and a placebo
CT - Depression subtypes and response to phenelzine, diazepam, and a placebo
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/01/01/
VL - 30
IS - Jan
SP - 66
EP - 75
AD - National Institute of Mental Health, Psychopharmacology Research Branch, Rm 9-101, 5600 Fishers Lane, Rockville, Maryland 20952
N1 - Accession Number: 12-0306; Language: English; Trade Name: Nardil--Valium; Generic Name: Phenelzine; Diazepam; Chemical Name: Diazepam--439-14-5 Phenelzine--51-71-8; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants phenelzine, comparison, diazepam (28:16.08); AHFS Class: Tranquilizers diazepam, comparison, phenelzine; References: 62; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A 7-week double blind study of 325 newly admitted depressed patients randomly assigned to treatment with either diazepam, phenelzine or placebo is presented. Median daily dosages were 30 mg. of diazepam and 45 mg. of phenelzine. The major study finding was the differential effects of diazepam (Valium) for patients categorized as anxious and hostile depressions. There was a significant number of anxious-depressive patients who were diazepam responders, i.e., their symptoms subsided on this treatment and became worse when this drug was discontinued. In contrast, diazepam was a poor treatment for the hostile depressions. These patients were restless, anxious, negativistic, suspicious and irritable when they entered the study. These symptoms persisted on diazepam and improved on either phenelzine (Nardil) or a placebo.
KW - Diazepam--comparison, phenelzine-;
KW - Phenelzine--comparison, diazepam-;
KW - Antidepressants--phenelzine, comparison, diazepam--depression, anxious versus hostile, therapy, in patients;
KW - Tranquilizers--diazepam, comparison, phenelzine--depression, anxious versus hostile, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - CHAP
ID - 2007-11499-023
AN - 2007-11499-023
AU - Engel, Bernard T.
AU - Bleecker, Eugene R.
ED - Obrist, Paul A.
ED - Black, A. H.
ED - Brener, Jasper
ED - DiCara, Leo V.
ED - Obrist, Paul A., (Ed)
ED - Black, A. H., (Ed)
ED - Brener, Jasper, (Ed)
ED - DiCara, Leo V., (Ed)
T1 - Application of operant conditioning techniques to the control of the cardiac arrhythmias.
T2 - Cardiovascular psychophysiology: Current issues in response mechanisms, biofeedback and methodology.
Y1 - 1974///
SP - 456
EP - 476
CY - New Brunswick, NJ, US
PB - AldineTransaction
SN - 0-202-36146-2
SN - 978-0-202-36146-8
N1 - Accession Number: 2007-11499-023. Partial author list: First Author & Affiliation: Engel, Bernard T.; Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute of Child Health and Human Development, Baltimore, MD, US. Reprinted: 2008. Release Date: 20080414. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-202-36146-2, Paperback; 978-0-202-36146-8, Paperback. Language: English. Major Descriptor: Arrhythmias (Heart); Cardiovascular Reactivity; Cardiovascular System; Operant Conditioning. Classification: Cardiovascular Disorders (3295). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 21.
AB - It is the intent of this chapter to review a number of studies which we and our colleagues have carried out in an attempt to evaluate the clinical application of operant conditioning techniques in the control of cardiac arrhythmias. The research we will be describing here also was designed to enable us to learn more about the control mechanisms of the heart; however, that aspect of our work has been reviewed elsewhere (Engel 1972). Any considerations of mechanisms in this chapter will be limited to speculations about how operant conditioning procedures might be useful diagnostically or how these procedures might be therapeutically useful, both as adjuncts to other forms of therapy and by themselves. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - operant conditioning techniques
KW - control mechanisms
KW - cardiac arrhythmias
KW - 1974
KW - Arrhythmias (Heart)
KW - Cardiovascular Reactivity
KW - Cardiovascular System
KW - Operant Conditioning
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cohen, M. H.
AU - Sibal, L. R.
AU - Fink, Mary A.
T1 - Relative Importance of Viral and Neoantigens in Cytotoxic Reaction Against Murine Leukaemia Cells.
JO - Immunology
JF - Immunology
Y1 - 1974/01//
VL - 26
IS - 1
M3 - Article
SP - 37
EP - 48
PB - Wiley-Blackwell
SN - 00192805
AB - Monkeys and mice were immunized with Rauscher murine leukaemia virus. Two types of leukaemia virus preparations were used as immunogens. One preparation was derived from viraemic plasma and was highly purified by density gradient ultracentrifugation. The other preparation of Rauscher virus was derived from spleen cells and was contaminated with cell membranes. Following immunization with each of these preparations sensitive techniques were utilized to measure antiviral and antileukaemia cell ('cytotoxic') antibody levels on aliquots of the same antiserums. Multiple serums from each animal were tested during the weeks of immunization in order to establish a parallelism or lack of parallelism in the changes in cytotoxic and antiviral antibody levels. In each antiserum the cytotoxic and antiviral titres were virtually the same. This was true whether the animal had been immunized with a purified or a non-purified virus preparation. The presence or absence of contaminating cell membrane material in the immunizing material did not result in an antiserum with increased or decreased cytotoxic to antiviral antibody ratio. This indicated that cytotoxic antibody is probably not the result of immunization against cell membrane antigens ('neoantigens') as distinguished from virus or virion subunit antigens. Conversely, we found that leukaemia cells containing relatively little virus did not lyse in the presence of cytotoxic antibody prepared against either membrane-rich or membrane-poor virus preparations. This finding suggests that virus and not independent neoantigen renders the leukaemia cell lysable by cytotoxic antibody. Our studies therefore minimize the significance and even question the presence of neoantigens in Rauscher leukaemia cells, since the cytotoxic capability of anti-Rauscher antiserum is dependent on the presence of virus and not neoantigen in the immunizing preparations, and since virus and not neoantigen renders the infected cell lysable by anti-Rauscher antibody. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRACENTRIFUGATION
KW - CELL membranes
KW - CELLS
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - IMMUNITY
N1 - Accession Number: 12827705; Cohen, M. H. 1,2 Sibal, L. R. 1,2 Fink, Mary A. 1,2; Affiliation: 1: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 2: Immunology Section, Viral Leukemia and Lymphoma Branch, National Cancer Institute, Rational Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan74, Vol. 26 Issue 1, p37; Subject Term: ULTRACENTRIFUGATION; Subject Term: CELL membranes; Subject Term: CELLS; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNITY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kuch, T D C
AU - Magnuson, Robert
T1 - A network-oriented interactive system for computer-supported indexing
JO - In Zunde, Pranas, Ed. Information Utilities. Proceedings Of The American Society For Information Science. Volume 11. 37th Annual Meeting, Atlanta, Georgia, October 13-17, 1974. 1974. Asis, Washington. P. 63-68. 1 Illus. 6 Ref. See Isa 74-3376/y
JF - In Zunde, Pranas, Ed. Information Utilities. Proceedings Of The American Society For Information Science. Volume 11. 37th Annual Meeting, Atlanta, Georgia, October 13-17, 1974. 1974. Asis, Washington. P. 63-68. 1 Illus. 6 Ref. See Isa 74-3376/y
Y1 - 1974///
M3 - Book
AB - 'indexing' covers a multitude of activities, from traditional human booking-indexing through key-word indexing to automatic generation of authority lists and search terms from articles and abstracts. The latter types have been thoroughly computerized and covered in the literature. Use of the computer as an aid to traditional book-indexing, however, has received little attention. In a previously reported project, a general-purpose textediting interactive system, wylbur, was used to aid human indexing of the collected issues of a technical journal. In the light of previous experience, we designed a language, mag-net, for support of indexing. The code was written in rmag. The language was designed for ease of syntactical debugging and of explanation, without use of special keys, rockers, or light pens.
N1 - Accession Number: ISTA0903184; Kuch, T D C 1; Magnuson, Robert; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland.; Source Info: 1974; Note: Update Code: 0900; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Chafetz, M. E.;
T1 - Alcoholism: drug dependency problem number one
CT - Alcoholism: drug dependency problem number one
JO - Journal of Drug Issues (USA)
JF - Journal of Drug Issues (USA)
Y1 - 1974/01/01/
VL - 4
IS - Jan
SP - 64
EP - 68
SN - 00220426
AD - Director, National Institute on Alcohol Abuse and Alcoholism, Department of Health, Education, and Welfare, Washington, D.C.
N1 - Accession Number: 11-3444; Language: English; Journal Coden: JDGIA6; Section Heading: Sociology, Economics and Ethics; Abstract Author: Pamela N. Davis
N2 - Some major programs and issues of the federal alcoholism effort are discussed, and the role of alcoholism programs in the nation's efforts to solve this problem is considered.
KW - Alcoholism--therapy--programs, federal, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Levis, William R.
AU - Whalen, John J.
AU - Miller, A. Edgar
AU - Jr.
T1 - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS II. Lymphokine Production in Allergic Contact Dermatitis to Dinitrochlorobenzene.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/01//
VL - 62
IS - 1
M3 - Article
SP - 2
EP - 6
SN - 0022202X
AB - A cell-free soluble factor(s) was specifically generated in primary leukocyte cultures during interaction of lymphocytes from a dinitrochlorobenzene (DNCB)-sensitized subject with DNCB-erythrocyte complexes (DNCB-antigen). The factor(s) was capable of inducing blastogenesis and DNA synthesis in secondary autologous DNCB-sensitive leukocyte cultures and in leukocyte cultures of allogeneic subjects who had not been sensitized to DNCB. Under the culture conditions employed to generate the factor(s), maximal DNA synthesis was induced in secondary "insensitive" cultures by supernates collected after 1-3 days of primary culture. Higher concentrations of primary stimulated culture supernates induced greater degrees of DNA synthesis in secondary "insensitive" leukocyte cultures with instances of greater than 100-fold stimulation. The discovery of lymphokine activity in experimentally induced allergic contact dermatitis offers a new and advantageous approach for investigating the biologic significance of these substances and may assist in better understanding cell-mediated immunity and the relationship of allergic contact dermatitis to other forms of delayed type hypersensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFER factor (Immunology)
KW - LYMPHOKINES
KW - DNA
KW - LEUCOCYTES
KW - BLASTOGENESIS (Embryology)
KW - IMMUNITY
KW - ALLERGY
N1 - Accession Number: 12676706; Levis, William R. 1 Whalen, John J. 1 Miller, A. Edgar Jr. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health. Bethesda. Maryland 20014.; Source Info: Jan1974, Vol. 62 Issue 1, p2; Subject Term: TRANSFER factor (Immunology); Subject Term: LYMPHOKINES; Subject Term: DNA; Subject Term: LEUCOCYTES; Subject Term: BLASTOGENESIS (Embryology); Subject Term: IMMUNITY; Subject Term: ALLERGY; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12676706
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Clarke, Robert F
T1 - Catalog card produced bibliographies
JO - Special Libraries
JF - Special Libraries
Y1 - 1974/01//
VL - 65
IS - 1
M3 - Article
SP - 26
EP - 27
SN - 00386723
AB - Removing cards temporarily from the card catalog and photocopying them serves as a quick, efficient means to produce typographically error free bibliographies which require no proofreading or correcting. This practical resulted in a 15% reduction in bibliography compilation time and a 97% reduction in clerical time.
N1 - Accession Number: ISTA0900911; Clarke, Robert F 1; Affiliations: 1 : National Institutes Of Health Library, Bethesda, Maryland.; Source Info: January 1974, Vol. 65 Issue 1, p26; Note: Update Code: 0900; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2013-41576-010
AN - 2013-41576-010
AU - Mannino, Fortune V.
AU - Shore, Milton F.
T1 - Family structure, aftercare, and post-hospital adjustment.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1974/01//
VL - 44
IS - 1
SP - 76
EP - 85
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Mannino, Fortune V., Mental Health Study Center, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-41576-010. PMID: 4358590 Partial author list: First Author & Affiliation: Mannino, Fortune V.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aftercare; Family Structure; Program Development; Treatment Outcomes. Minor Descriptor: Adjustment; Hospitals; Innovation. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Katz Scale; KAS Form RS 4 Level of Freetime Activities; KAS Form S2 Level of Performance of Socially Expected Activities; Social Adequacy Rating Scale of Pinchak and Rollins. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan, 1974.
AB - This follow-up study of an innovative aftercare program compares a group of former patients who participated with a control group; explores the effects of family structure and sex on post-hospital adjustment; and evaluates the relationship of family structure to treatment outcome. Results replicate previous findings that have shown an association between family structure and post-hospital adjustment. Findings confirm the importance of family variables in analyzing program effectiveness, as well as in program planning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family structure
KW - innovative aftercare programs
KW - post hospital adjustment
KW - program planning
KW - treatment outcome
KW - 1974
KW - Aftercare
KW - Family Structure
KW - Program Development
KW - Treatment Outcomes
KW - Adjustment
KW - Hospitals
KW - Innovation
KW - 1974
DO - 10.1111/j.1939-0025.1974.tb00871.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41576-019
AN - 2013-41576-019
AU - Shore, Milton F.
T1 - Review of Mental health: From infancy through adolescence; The mental health of children: Services, research and manpower; and Social change and the mental health of children.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1974/01//
VL - 44
IS - 1
SP - 159
EP - 162
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41576-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Care; Mental Health Programs; Personnel Supply; Social Change. Classification: Community & Social Services (3373). Population: Human (10). Reviewed Item: No authorship indicated. Mental health: From infancy through adolescence=Joint Commission on Mental Health of Children: Report of Task Forces I, II, and Ill, and the Committees on Education and Rehg1on. 470 pp. $15.00. Harper & Row, New York; 1973. No authorship indicated. The mental health of children: Services, research and manpower=Joint Commission on the Mental Health of Children: Report of Task Forces IV and V, and the Report of the Committee on Clinical Issues. 446 pp. $15.00. Harper & Row, New York; 1973. No authorship indicated. Social change and the mental health of children=Joint Commission on the Mental Health of Children: Report of Task Force VI, and Excerpts from the Report of the Committee on Children of Minority Groups. 225 pp. $8.50. Harper & Row, New York; 1973. References Available: Y. Page Count: 4. Issue Publication Date: Jan, 1974.
AB - Reviews the books, Mental Health: From Infancy through Adolescence (see record [rid]1973-31768-000[/rid]); The Mental Health of Children: Services, Research and Manpower (see record [rid]1973-31770-000[/rid]); and Social Change and the Mental Health of Children (see record [rid]1973-31769-000[/rid]). The three volumes of task force and committee reports under review clearly show the difficulty in dividing the area of child mental health for study. There is no doubt that the volumes of the Joint Commission on the Mental Health of Children are extraordinarily comprehensive documents with masses of substantive data, reflecting the current knowledge in the field of the mental health of children as seen by major experts in the field. One can criticize the style and the approach. One can fault it for lack of focus. One can wish priorities were more carefully spelled out. One can disagree with the approaches and take sides as to whether the report should have had a better balance of the clinical and the social, with more emphasis on the services needed for the mentally ill child and his family. In an atmosphere characterized by a deep concern for the welfare of children and youth and support for the free exchange of ideas, the most viable proposals are often identified and nurtured, while others wither and die. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children services
KW - child mental health research
KW - manpower
KW - social change
KW - 1974
KW - Child Care
KW - Mental Health Programs
KW - Personnel Supply
KW - Social Change
KW - 1974
U2 - No authorship indicated. (1973); Mental health: From infancy through adolescence; Joint Commission on Mental Health of Children: Report of Task Forces I, II, and Ill, and the Committees on Education and Rehg1on. 470 pp. $15.00. Harper & Row, New York
U2 - No authorship indicated. (1973); The mental health of children: Services, research and manpower; Joint Commission on the Mental Health of Children: Report of Task Forces IV and V, and the Report of the Committee on Clinical Issues. 446 pp. $15.00. Harper & Row, New York
U2 - No authorship indicated. (1973); Social change and the mental health of children; Joint Commission on the Mental Health of Children: Report of Task Force VI, and Excerpts from the Report of the Committee on Children of Minority Groups. 225 pp. $8.50. Harper & Row, New York
DO - 10.1111/j.1939-0025.1974.tb00880.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - DALE, DAVID C.
AU - GRAW JR., ROBERT G.
T1 - Transplantation of Allogeneic Bone Marrow in Canine Cyclic Neutropenia.
JO - Science
JF - Science
Y1 - 1974/01/11/
VL - 183
IS - 4120
M3 - Article
SP - 83
EP - 84
SN - 00368075
AB - Transplantation of normal bone marrow cells to a gray collie dog with cyclic neutropenia resulted in normal granulocytopoiesis. The finding suggests that cyclic neutropenia occurs because the hematopoietic stem cells are defective. Because of the similarity of human and canine cyclic neutropenia, it also suggests that the human disease may be curable by marrow transplantation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85344890; DALE, DAVID C. 1; GRAW JR., ROBERT G. 2; Affiliations: 1: Laboratory of Clinical Investigation, National Institute-of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Experimental Hematology Section, Pediatric Oncology Branch. National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p83; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BENSINGER, RICHARD E.
AU - FLETCHER, R. THEODORE
AU - CHADER, GERALD J.
T1 - Guanylate Cyclase: Inhibition by Light in Retinal Photoreceptors.
JO - Science
JF - Science
Y1 - 1974/01/11/
VL - 183
IS - 4120
M3 - Article
SP - 86
EP - 87
SN - 00368075
AB - Guanylate cyclase activity of retinal rod outer segments was measured by an assay procedure that minimizes the technical problems caused by the high activity of cyclic nucleotide phosphodiesterase in neural tissue. Cyclase activity in rods is significantly higher than in brain. Moreover, activity is twofold higher in dark-adapted rods than in light-bleached rods, a sensitivity that is lost when the preparation is treated with detergent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85344892; BENSINGER, RICHARD E. 1,2; FLETCHER, R. THEODORE 1; CHADER, GERALD J. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p86; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHO-CHUNG, YOON SANG
AU - GULLINO, PIETRO M.
T1 - In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP.
JO - Science
JF - Science
Y1 - 1974/01/11/
VL - 183
IS - 4120
M3 - Article
SP - 87
EP - 88
SN - 00368075
AB - Growth of hormone-dependent rat mammary tumors was arrested in vivo by N6,O²'-dibutyryl cyclic adenosine 3',5'-monophosphate. Estrogen concentration did not change, but acid ribonuclease activity and synthesis increased during treatment with the dibutyryl cyclic nucleotide, as was shown during tumor regression due to hormonal deprivation. Growth arrest, thus, appears to derive from enhanced tissue catabolism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85344893; CHO-CHUNG, YOON SANG 1; GULLINO, PIETRO M. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/11/1974, Vol. 183 Issue 4120, p87; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROSS, PHILIP D.
T1 - NMicrocalorimetry Techniques: Applications to Cellular Systems.
JO - Science
JF - Science
Y1 - 1974/01/18/
VL - 183
IS - 4121
M3 - Article
SP - 225
EP - 225
SN - 00368075
N1 - Accession Number: 85344944; ROSS, PHILIP D. 1; Affiliations: 1: Laboratory of Molecular Biology, National Institute of Arthritis, Aletabolismn, and Digestive Diseeases, National Institutes of Health, Bethesda. Marvland 200714; Issue Info: 1/18/1974, Vol. 183 Issue 4121, p225; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Raskin, A.;
T1 - Guide for drug use in depressive disorders
CT - Guide for drug use in depressive disorders
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1974/02/01/
VL - 131
IS - Feb
SP - 181
EP - 185
SN - 0002953X
AD - Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 12-0303; Language: English; Chemical Name: Imipramine--50-49-7 Chlorpromazine--50-53-3 Diazepam--439-14-5 Phenelzine--51-71-8; References: 42; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: C. Robert Sturwold
N2 - During a 7-week study involving 880 moderate to severe depressed patients, psychotropic medications were examined for their selective effects on the major symptoms of depression. The following median daily doses of antidepressants were administered: imipramine, 300 mg. (200 patients); chlorpromazine, 600 mg. (176 patients) diazepam, 30 mg. (104 patients); phenelzine, 45 mg. (110 patients); and placebo (290 patients). Evalutations were made at the end of 1, 2, 3, 5, and 7 weeks. Thirty-six percent of the patients receiving placebo and 44% of the patients receiving active agents showed improvement after 3 weeks. Guidelines were suggested for the treatment of the major symptoms of depression and it was noted that for many patients, depression is a self-limiting illness with a high spontaneous recovery and high placebo response.
KW - Imipramine--depression-;
KW - Chlorpromazine--depression-;
KW - Diazepam--depression-;
KW - Phenelzine--depression-;
KW - Psychotherapeutic agents--depression--therapy, guidelines, in patients;
KW - Guidelines--psychotherapeutic agents--depression, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Schneiderman, Marvin A.
T1 - DESEGREGATING HEALTH STATISTICS.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/02//
VL - 64
IS - 2
M3 - Letter
SP - 98
EP - 172
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Desegregating Health Statistics," by Milton Terris in the June 1973 issue.
KW - Letters to the editor
KW - Medical statistics
N1 - Accession Number: 14093953; Schneiderman, Marvin A. 1; Affiliations: 1: Associate Director for Field, Studies and Statistics, DCCP National Cancer Institute, Bethesda, MD; Issue Info: Feb1974, Vol. 64 Issue 2, p98; Subject Term: Letters to the editor; Subject Term: Medical statistics; Number of Pages: 4p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Post, R. M.;
AU - Goodwin, F. K.;
T1 - Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients
CT - Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/02/01/
VL - 30
IS - Feb
SP - 234
EP - 239
AD - 3-West Unit, Adult Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 11-4468; Language: English; Trade Name: Presamine--Tofranil--Elavil; Generic Name: Imipramine; Imipramine; Amitriptyline; Chemical Name: Amitriptyline--50-48-6 Imipramine--50-49-7; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants amitriptyline (28:16.04); AHFS Class: Antidepressants imipramine; References: 58; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Ten depressed patients who received amitriptyline (Elavil) or imipramine (Presamine; Tofranil) at doses ranging from 150 to 350 mg./day for an average of 25 days had lower levels of 5-hydroxyindoleacetic acid, a serotonin metabolite, in the cerebrospinal fluid (CSF) when compared to values obtained from untreated patients. Both drugs reduced the base line levels and the probenecid-induced accumulations of 5-hydroxyindoleacetic acid in the CSF of depressed patients but did not affect the accumulation of homovanillic acid, metabolite of brain dopamine. Probenecid given in divided doses for a total of 100 mg./kg. caused a rapid accumulation of CNS neurotransmitter metabolites by inhibiting transport out of the CNS. It was suggested that tricyclic antidepressants reduce the CNS serotonin turnover.
KW - Amitriptyline--mechanism of action-;
KW - Imipramine--mechanism of action-;
KW - Antidepressants--amitriptyline--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW - Antidepressants--imipramine--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW - Mechanism of action--amitriptyline--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
KW - Mechanism of action--imipramine--reduction, 5-hydroxyindoleacetic acid, CSF levels, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - McDonald, Henry
T1 - Implanting Human Values into Genetic Control.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1974/02//
VL - 30
IS - 2
M3 - Article
SP - 21
EP - 22
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21570026; McDonald, Henry 1; Affiliation: 1: Technical Information Specialist, National Cancer Institute, National Institutes of Health; Source Info: Feb1974, Vol. 30 Issue 2, p21; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - DeFranzo, R. A.;
AU - Colvin, O. M.;
AU - Braine, H.;
AU - Robertson, G. L.;
AU - Davis, P. J.;
T1 - Cyclophosphamide and the kidney
CT - Cyclophosphamide and the kidney
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1974/02/01/
VL - 33
IS - Feb
SP - 483
EP - 491
AD - Metabolism Section, Clinical Physiology Branch, Geronotology Research Center, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland
N1 - Accession Number: 12-5056; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 20; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effect of cyclophosphamide on renal function was studied in 17 normally hydrated patients with cancer. No nephrotoxic effects were observed. Doses of cyclophosphamide over 50 mg/kg did, however, impair water excretion as manifested by weight gain, hyponatremia, and inappropriately concentrated urine. The decrease in serum osmolarity (range 6-12 mOsm/l) and increase in urine osmolarity (range 305-798 mOsm/l) occurred 4-12 hr after cyclophosphamide administration, lasted 20-24 hr, and correlated temporally with the urinary excretion of cyclophosphamide alkylatine metabolites. No change in creatinine clearance or urinary excretion of protein, sodium, potassium, calcium, phosphorus, uric acid, and amino acids was observed after cyclophosphamide.
KW - Cyclophosphamide--toxicity-;
KW - Antineoplastic agents--cyclophosphamide--toxicity, lack, renal, in cancer patients;
KW - Excretion--cyclophosphamide--and lack of renal toxicity, in patients;
KW - Metabolism--cyclophosphamide--excretion, lack of renal toxicity, in patients;
KW - Toxicity--cyclophosphamide--lack, renal, in cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bryan, J. H.;
AU - Henderson, E. S.;
AU - Leventhal, B. G.;
T1 - Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
CT - Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1974/02/01/
VL - 33
IS - Feb
SP - 539
EP - 544
AD - Bldg. 10, Room 3B-06, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-4658; Language: English; Chemical Name: Cytarabine--147-94-4 Thioguanine--154-42-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cytarabine and thioguanine (10:00); AHFS Class: Antineoplastic agents thioguanine and cytarabine; References: 17; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The efficacy of the combination of 100 mg/m\SU/2\BS/ IV or SC cytosine arabinoside (cytarabine) with 75-100 mg/m\SU/2\BS/ oral thioguanine was tested in 19 children with acute lymphocytic leukemia. Duration of therapy was variable, depending on patient response. Complete remissions were obtained in 9 patients. Severe marrow hypoplasia and pancytopenia were the most common side effects, along with mild nausea, vomiting, and minimally abnormal liver function tests.
KW - Cytarabine--and thioguanine-;
KW - Thioguanine--and cytarabine-;
KW - Antineoplastic agents--cytarabine and thioguanine--leukemias, acute lymphocytic, evaluation, in children;
KW - Combined therapy--cytarabine and thioguanine--leukemias, acute lymphocytic, evaluation, in children;
KW - Combined therapy--thioguanine and cytarabine--leukemias, acute lymphocytic, evaluation, in children;
KW - Antineoplastic agents--thioguanine and cytarabine--leukemias, acute lymphocytic, evaluation, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - De Bracco, Maria M. E.
AU - Windhorst, Dorothy
AU - Stroud, R. M.
AU - Moncada, B.
T1 - THE AUTOSOMAL RECESSIVE MODE OF INHERITANCE OF C1r DEFICIENCY IN A LARGE PUERTO RICAN FAMILY.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1974/02//
VL - 16
IS - 2
M3 - Article
SP - 183
EP - 188
PB - Wiley-Blackwell
SN - 00099104
AB - All living members of three generations of a large family with Clr deficiency were studied. The two index cases showed undetectable CIr and partial deficiency of Cls associated with cutaneous, renal and joint disease as described previously (Moncada et al, 1972). The quantitative Clq, Cl rand Cls studies on the parents and the normal siblings were consistent with an autosomal recessive mode of inheritance for the Clr trait. There was more correlation of the Clr levels with the Cls levels than with the CIq levels, compatible with a linkage of the synthesis or catabolism of Cls with Clr. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - DEFICIENCY diseases
KW - FAMILIES
KW - GENERATIONS
KW - PARENTS
KW - HEALTH
N1 - Accession Number: 16223807; De Bracco, Maria M. E. 1 Windhorst, Dorothy 2 Stroud, R. M. 1 Moncada, B. 3,4; Affiliation: 1: Instituto de Investigaciones Medicas, Universidad de Buenos Aires, Buenos Aires, Argentina 2: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 2004, U.S.A. 3: Division of Dermatology, University of Chicago, Chicago, Illinois 4: Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, University Station, Birmingham, Alabama 35294, U.S.A.; Source Info: Feb1974, Vol. 16 Issue 2, p183; Subject Term: METABOLISM; Subject Term: DEFICIENCY diseases; Subject Term: FAMILIES; Subject Term: GENERATIONS; Subject Term: PARENTS; Subject Term: HEALTH; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Nutt, J. G.;
AU - Jusinski, D. R.;
T1 - Methadone-naloxone mixtures for use in methadone maintenance programs. 1. An evaluation in man of their pharmacological feasibility. 2. Demonstration of acute physical dependence
CT - Methadone-naloxone mixtures for use in methadone maintenance programs. 1. An evaluation in man of their pharmacological feasibility. 2. Demonstration of acute physical dependence
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/02/01/
VL - 15
IS - Feb
SP - 156
EP - 166
SN - 00099236
AD - National Institute on Drug Abuse Addiction Research Center, U. S. Dept. of H. E. W., Alcohol, Drug Abuse, and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 12-6143; Language: English; Chemical Name: Naloxone--465-65-6 Methadone--76-99-3; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Mixtures of methadone (I) and naloxone (II) were substituted for the I dispensed in methadone maintenance programs to reduce diversion for purposes of abuse. By the oral route in nondependent subjects I-II mixtures are indistinguishable from I alone. By the IV route, the mixtures have significantly less miotic, behavioral and subjective effects than I alone. Administration of I-II to morphine dependent subjects ameliorates but does not abolish the abstinence precipitated by II. II 10 mg administered orally does not precipitate abstinence in morphine dependent subjects, and doses of 15 and 30 mg produce only mild signs of abstinence. It was concluded that I-II mixtures could be compounded that would be interchangeable with I intended for oral consumption, but have less parenteral abuse liability than I. The observation that 4 mg IV naloxone precipitated signs of abstinence one week after a single dose of I indicated the development of acute physical dependence on I.
KW - Naloxone--combination, methadone-;
KW - Methadone--combination, naloxone-;
KW - Narcotic antagonists--naloxone, combination, methadone--reduction, IV abuse potential, in methadone maintenance patients;
KW - Drug abuse--methadone--reduction, combined with naloxone, in patients;
KW - Dependence--methadone--reduction, abuse potential, combined with naloxone, in patients;
KW - Drug administration--routes--effects, methadone-naloxone combination, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Corfman, P. A.;
T1 - Coordinated studies of the effects of oral contraceptives
CT - Coordinated studies of the effects of oral contraceptives
JO - Contraception (USA)
JF - Contraception (USA)
Y1 - 1974/02/01/
VL - 9
IS - Feb
SP - 109
EP - 122
SN - 00107824
AD - National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-4110; Language: English; References: 13; Journal Coden: CCPTAY; Human Indicator: Yes; Section Heading: Toxicity
N2 - The data obtained from a national program on the medical effects of oral contraceptives are reported. The study confirms previous data which relates oral contraceptive use with increased risk of thromboembolism. A retrospective study shows increased risk of stroke with users. Retrospective studies also show no increased risk of breast cancer at this time. It was also noted that there has been a significant change in American contraceptive practice with the use of oral contraceptives increasing by 10% between 1965 and 1970. A selected list of disorders implicated with oral contraceptives includes: thromboembolism, stroke, breast and cervical cancer, decreased carbohydrate tolerance, increased plasma lipids, impaired liver function, jaundice and increased blood pressure.
KW - Toxicity--contraceptives, oral--studies, national, U.S., in women;
KW - Contraceptives, oral--toxicity--studies, national, U.S., in women;
KW - Statistics--contraceptives, oral--toxicity, studies, national, U.S., in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Altman, L. C.
AU - Kirchner, H.
T1 - Mononuclear Leucocyte Chemotaxis in the Chicken. DEFINITION OF A PHYLOGENETICALLY SPECIFIC LYMPHOKINE.
JO - Immunology
JF - Immunology
Y1 - 1974/02//
VL - 26
IS - 2
M3 - Article
SP - 393
EP - 405
PB - Wiley-Blackwell
SN - 00192805
AB - Chicken leucocytes when stimulated in vitro with purified protein derivative (PPD), a specific antigen or concanavalin A (Con A), a nonspecific mitogen, produced a soluble factor which was chemotactic for homologous monocytes. The production of this factor, by PPD-stimulated spleen cells from PPD-immunized chickens was found to be a correlate of delayed skin reactivity. Leucocytes from the blood, spleen and thymus of chickens produced measurable amounts of mononuclear leucocyte chemotactic factor (MNL CTX); however, bursal lymphocytes failed to synthesize this mediator. Chicken MNL CTX was heat stable (56° for 30 minutes), nondialysable. remained active if frozen and thawed, and had an estimated molecular weight of 12,500 as determined by molecular sieve chromatography and sucrose density ultracentrifugation. Moreover, this lympho- kine was sensitive to treatment with pepsin and trypsin but not with neuraminidase. These results indicate that chicken MNL CTX is a protein whose activity is independent of sialic acid. The physical characteristics of chicken MNL CTX are remarkably similar to those of a chemotactic lymphokine recently defined in man. However, chicken MNL CTX was not active in attracting human, guinea-pig or rabbit MNL, and chicken MNL failed to migrate in response to human or guinea- pig lymphokine CTX. These findings indicate that MNL CTX is a lymphokine whose activity is phylogenetically restricted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - BLOOD cells
KW - DIGESTIVE enzymes
KW - ENDOCRINE glands
KW - CHROMATOGRAPHIC analysis
KW - PANCREATIC secretions
N1 - Accession Number: 12827484; Altman, L. C. 1 Kirchner, H. 1; Affiliation: 1: Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Feb74, Vol. 26 Issue 2, p393; Subject Term: LYMPHOID tissue; Subject Term: BLOOD cells; Subject Term: DIGESTIVE enzymes; Subject Term: ENDOCRINE glands; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PANCREATIC secretions; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KREUZ, DAVID S.
AU - AXELROD, JULIUS
T1 - Amphetamine in Human Plasma: A Sensitive and Specific Enzymatic Assay.
JO - Science
JF - Science
Y1 - 1974/02//2/ 1/1974
VL - 183
IS - 4123
M3 - Article
SP - 420
EP - 421
SN - 00368075
AB - A sensitive and specific enzymatc-isotopic method of determining plasma amphetamine concentrations in man is described. The assay is based on the transfer of the tritiated methyl group of S-adenosyl-L-[methyl-³H]methionine to amphetamine in the presence of a partially purified N-methyltransferase from rabbit lung. With this assay as little as 10 nanograms of amphetamine per milliliter of plasma can be accurately determined. The concentrations of d- and 1-amphetamine in the plasma after 20 to 30 milligrams of the drug had been ingested by human subjects are reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85344977; KREUZ, DAVID S. 1; AXELROD, JULIUS 2; Affiliations: 1: Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 1/1974, Vol. 183 Issue 4123, p420; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - AARONSON, STUART A.
AU - DUNN, CLAIRE Y.
T1 - High-Frequency C-Type Virus Induction by Inhibitors of Protein Synthesis.
JO - Science
JF - Science
Y1 - 1974/02//2/ 1/1974
VL - 183
IS - 4123
M3 - Article
SP - 422
EP - 424
SN - 00368075
AB - When inhibitors of protein synthesis are added to BALBIc mouse cells in clulture, induction of naturally integrated C-type RNA virus occuls in a high percentage of cells. The action of protein synthesis inhibitors difters fromn that of halogenated pyrimidines, another class of virlus induicers, in their effects on biologically distinguishable virluses. The luse of sutch inhibitors to stludy integrated virus expression provides a means for studying gene reglulation in mammalian cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85344978; AARONSON, STUART A. 1; DUNN, CLAIRE Y. 2; Affiliations: 1: Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Hazleton Laboratories, Inc., Vienna, Virginia 22180; Issue Info: 2/ 1/1974, Vol. 183 Issue 4123, p422; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06259-037
AN - 2006-06259-037
AU - Stierlin, Helm
T1 - A Forced Awakening from Psychosis.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1974/02//
VL - 19
IS - 2
SP - 131
EP - 132
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06259-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Stierlin, Helm; Family Studies Section, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Mental Disorders; Schizophrenia; Treatment. Classification: Psychological Disorders (3210); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Honig, Albert M. The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill=Rockaway, N.J.: American Faculty Press, 1972. Pp. xi + 303. $9.95 cloth; $2.65 paper; 1972. Page Count: 2. Issue Publication Date: Feb, 1974.
AB - Reviews the book, The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill by Albert M. Honig (see record [rid]1974-01658-000[/rid]). The book elaborates the philosophy, view of mental illness, and therapeutic principles that guide the author. Rather than giving a systematic exposition, the book brings together a number of essays, some of which appeared as journal articles. However much one might disagree with aspects of author's philosophy or therapeutic approach, the fact remains that he has broken new ground where many others did not dare to tread. The author comes across as a strong therapeutic personality who can bring down to earth and back to reality even deeply and chronically disturbed schizophrenics. Anyone engaged in the long-term, intensive therapy of these patients will appreciate what this means. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental illness
KW - schizophrenia
KW - treatment
KW - 1974
KW - Mental Disorders
KW - Schizophrenia
KW - Treatment
KW - 1974
U2 - Honig, Albert M. (1972); The Awakening Nightmare: A Breakthrough in Treating the Mentally Ill; Rockaway, N.J.: American Faculty Press, 1972. Pp. xi + 303. $9.95 cloth; $2.65 paper
DO - 10.1037/0012467
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Bennett, J. E.;
T1 - Chemotherapy of systemic mycoses. Part II
CT - Chemotherapy of systemic mycoses. Part II
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/02/07/
VL - 290
IS - Feb 7
SP - 320
EP - 323
SN - 00284793
AD - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-3233; Language: English; Trade Name: Bay-b-5097--5-Fluorocytosine; Generic Name: Clotrimazole; Flucytosine; Chemical Name: Flucytosine--2022-85-7 Clotrimazole--23593-75-1; Therapeutic Class: (8:12.04); AHFS Class: Fungicides flucytosine (8:12.04); AHFS Class: Fungicides clotrimazole; References: 105; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - 5-Fluorocytosine (flucytosine; 5-FC) is discussed in regard to susceptibility, mechanism of action, experimental infections, clinical trials and adverse reactions when used to treat systemic mycoses. Also discussed are clotrimazole (Bay-b-5097), 2-hydroxystilbamidine and iodide.
KW - Flucytosine--mycoses-;
KW - Clotrimazole--mycoses-;
KW - Hydroxystilbamidine--mycoses-;
KW - Iodides--mycoses--systemic, therapy, in patients;
KW - Fungicides--flucytosine--mycoses, systemic, therapy, in patients;
KW - Fungicides--clotrimazole--mycoses, systemic, therapy, in patients;
KW - Fungicides--hydroxystilbamadine--mycoses, systemic, therapy, in patients;
KW - Fungicides--iodides--mycoses, systemic, therapy, in patients;
KW - Toxicity--flucytosine--side effects, mycoses, systemic, therapy, in patients;
KW - Mechanism of action--flucytosine--mycoses, systemic, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kashket, Eva Ruth
AU - Robbins, Mary Louise
AU - Leive, Loretta
AU - Huang, Alice S.
T1 - Status of Women Microbiologists.
JO - Science
JF - Science
Y1 - 1974/02/08/
VL - 183
IS - 4124
M3 - Article
SP - 488
EP - 494
SN - 00368075
N1 - Accession Number: 85345002; Kashket, Eva Ruth 1; Robbins, Mary Louise 2; Leive, Loretta 3; Huang, Alice S. 4; Affiliations: 1: Principal associate, department of physiology, Harvard Medical School, Boston, Massachusetts 02115; 2: Professor of microbiology, George Washington University Medical Center, Washington, D.C. 20005; 3: Research biologist, Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolic, Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 4: Associate professor of microbiology and molecular genetics, Harvard Medical School; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p488; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GARELIS, E.
AU - NEFF, N. H.
T1 - Cyclic Adenosine Monophosphate: Selective Increase in Caudate Nucleus after Administration of L-Dopa.
JO - Science
JF - Science
Y1 - 1974/02/08/
VL - 183
IS - 4124
M3 - Article
SP - 532
EP - 533
SN - 00368075
AB - Treatment with the dopamine precursor L-dopa produced a significant accumulation of adenosine 3',S'-monophosphate (cyclic AMP) in the caudate nucleus of the rat. In contrast, there was no change in the amount of cyclic AMP in the cerebellum. Accumulation of cyclic AMP in the caudate nucleus after administration of L-dopa was prevented by prior treatment with the decarboxylase inhibitor RO 4-4602. These observations and those in other laboratories support the assumption that dopainine formed from L-dopa selectively activates striatal adenylate cyclase. The in vivo activation of adenylate cyclase after treatment with L-dopa may be a useful model for studying neurological and psychiatric disorders that are thought to involve the dopaminergic system of the brain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345030; GARELIS, E. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p532; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PERRIN, CHARLES L.
AU - TING, KAI-LI H.
T1 - Testing of Computer-Assisted Methods for Classification of Pharmacological Activity.
JO - Science
JF - Science
Y1 - 1974/02/08/
VL - 183
IS - 4124
M3 - Article
SP - 551
EP - 552
SN - 00368075
N1 - Accession Number: 85345040; PERRIN, CHARLES L. 1; TING, KAI-LI H. 2; Affiliations: 1: Institute of Neurobiology, Göteborg University, Göteborg, Sweden; 2: Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 8/1974, Vol. 183 Issue 4124, p551; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Canellos, G. P.;
AU - DeVita, V. T.;
AU - Gold, G. L.;
AU - Chabner, B. A.;
AU - Schein, P. S.;
AU - \ET/;
T1 - Cyclical combination chemotherapy for advanced breast carcinoma
CT - Cyclical combination chemotherapy for advanced breast carcinoma
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1974/02/09/
VL - 1
IS - Feb 9
SP - 218
EP - 220
SN - 09598146
AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-3262; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Methotrexate--59-05-2 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide, fluorouracil, methotrexate and prednisone (10:00); AHFS Class: Antineoplastic agents fluorouracil, cyclophosphamide, methotrexate and prednisone (10:00); AHFS Class: Antineoplastic agents methotrexate, cyclophosphamide, fluorouracil and prednisone (10:00); AHFS Class: Antineoplastic agents prednisone, cyclophosphamide, fluorouracil and methotrexate; References: 10; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Twenty-five patients with advanced metastatic breast cancer were treated with the combination of methotrexate 60 mg./sq.m. and 5-fluorouracil 700 mg./sq.m. I.V. on the first and eighth days, and cyclophosphamide 100 mg./sq.m. and prednisone 40 mg./sq.m. by mouth daily for the first 14 days of a 28-day cycle. The patients had had no previous chemotherapy or extensive radiotherapy and all but 2 had not responded to hormonal therapy or endocrine ablation. The major metastatic lesions were: lung (12 patients), liver (4 patients), bone (4 patients), soft tissue (3 patients), nodes (2 patients). Seventeen of the 25 patients (68%) responded to treatment with 7 complete remissions; these included patients suffering metastatic lesions in the lung, nodes, and soft tissue. The overall median duration of response was 9 months (range 6-26 months). Toxicity was primarily hematological, but the group received an average of at least 75% of their calculated dose for each monthly cycle. Hematological toxicity was most pronounced in patients with liver dysfunction and bone marrow involvement. Out of 8 nonresponders 7 died, with a median survival of 6 months. Only 6 of 17 responders died, and the median survival in this group will exceed 13 months. There was no correlation between the length of the metastasis-free interval after previous treatment and subsequent response to chemotherapy.
KW - Cyclophosphamide--fluorouracil, methotrexate and prednisone-;
KW - Fluorouracil--cyclophosphamide, methotrexate and prednisone-;
KW - Methotrexate--cyclophosphamide, fluorouracil and prednisone-;
KW - Prednisone--cyclophosphamide, fluorouracil and methotrexate-;
KW - Combined therapy--cyclophosphamide, fluorouracil, methotrexate and prednisone--cyclical, advanced breast carcinomas, in patients;
KW - Combined therapy--fluorouracil, cyclophosphamide, methotrexate and prednisone--cyclical, advanced breast carcinomas, in patients;
KW - Combined therapy--methotrexate, cyclophosphamide, fluorouracil and prednisone--cyclical, advanced breast carcinomas, in patients;
KW - Combined therapy--prednisone, cyclophosphamide, fluorouracil and methotrexate--cyclical, advanced breast carcinomas, in patients;
KW - Antineoplastic agents--cyclophosphamide, fluorouracil, methotrexate and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW - Antineoplastic agents--fluorouracil, cyclophosphamide, methotrexate and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW - Antineoplastic agents--methotrexate, cyclophosphamide, fluorouracil and prednisone--combined therapy, cyclical, advanced breast carcinoma, in patients;
KW - Antineoplastic agents--prednisone, cyclophosphamide, fluorouracil and methotrexate--combined therapy, cyclical, advanced breast carcinoma, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - FRIEDMAN, THOMAS B.
AU - YARKIN, RHODA J.
AU - MERRIL, CARL R.
T1 - Galactosemia and Galactonolactone: Further Biochemical Observations.
JO - Science
JF - Science
Y1 - 1974/02/22/
VL - 183
IS - 4126
M3 - Article
SP - 764
EP - 766
SN - 00368075
N1 - Accession Number: 85345112; FRIEDMAN, THOMAS B. 1; YARKIN, RHODA J. 1; MERRIL, CARL R. 1; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/22/1974, Vol. 183 Issue 4126, p764; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Zunino, F.;
AU - Gambetta, R.;
AU - DiMarco, A.;
AU - Zaccara, A.;
AU - Luoni, G.;
T1 - Comparison of the effects of daunomycin (daunorubicin) and adriamycin on various DNA polymerases
CT - Comparison of the effects of daunomycin (daunorubicin) and adriamycin on various DNA polymerases
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1974/03/01/
VL - 35
IS - Mar
SP - 754
EP - 760
SN - 00085472
AD - Div. of Experimental Onocology B, National Cancer Institute, Via Venezian 1, 20133 Milan, Italy
N1 - Accession Number: 12-5790; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Daunorubicin--20830-81-3 Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin, comparison, doxorubicin (10:00); AHFS Class: Antineoplastic agents doxorubicin, comparison, daunorubicin; References: 43; Journal Coden: CNREA8; Section Heading: Investigational Drugs; Pharmacology
N2 - The effects of daunomycin and adriamycin (doxorubicin) on the DNA-directed activities of DNA polymerases from murine sarcoma virus, rat liver (high-molecular-weight species), Escherichia coli, and Micrococcus luteus were determined. Under all conditions tested, these compounds had greater inhibitory effect against the viral polymerase than against cellular polymerase. The inhibition of murine sarcoma virus DNA polymerase by daunomycin was competitive with respect to DNA. For viral DNA polymerase it was concluded that the inhibition was predominately caused by the interaction of daunomycin with the primer-template DNA. Also, an appreciable reversal of the daunomycin-induced inhibition of this polymerase by an increase in Mg\SU/2+\BS/ concentration is consistent with the conclusion derived by competition experiments. In contrast, the inhibition of both rat liver and M. luteus DNA polymerases was essentially noncompetitive with DNA. Also, bacterial enzymes were less sensitive to inhibition by those drugs than the virion polymerase. The strong and preferential inhibition of viral DNA polymerase is discussed in relation to a differential sensitivity of normal as compared to tumor cells observed in some cell lines.
KW - Daunorubicin--comparison, doxorubicin-;
KW - Doxorubicin--comparison, daunorubicin-;
KW - Antineoplastic agents--daunorubicin, comparison, doxorubicin--effects, on various DNA polymerases;
KW - Antineoplastic agents--doxorubicin, comparison, daunorubicin--effects, on various DNA polymerases;
KW - Mechanism of action--daunorubicin, comparison, doxorubicin--effects, on various DNA polymerases;
KW - Mechanism of action--doxorubicin, comparison, daunorubicin--effects, on various DNA polymerases;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Yang, Raymond K.
AU - Douthitt, Thomas C.
T1 - Newborn Responses to Threshold Tactile Stimulation.
JO - Child Development
JF - Child Development
Y1 - 1974/03//
VL - 45
IS - 1
M3 - Article
SP - 237
EP - 242
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12275034; Yang, Raymond K. 1 Douthitt, Thomas C. 1; Affiliation: 1: Child Research Branch, National Institute of Mental Health.; Source Info: Mar1974, Vol. 45 Issue 1, p237; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1467-8624.ep12275034
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mantel, Nathan
AU - Byar, David P.
T1 - Evaluation of Response-Time Data Involving Transient States: An Illustration Using Heart-Transplant Data.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/03//
VL - 69
IS - 345
M3 - Article
SP - 81
SN - 01621459
AB - The problem considered is how to compare time-to-response data for different groups when the group membership of an individual can be arbitrarily varied during a study. Modified life tables can be constructed which reflect such changes in an individual's status, and associated measures of relative risk and statistical significance calculated. This is illustrated with survival data for heart-transplant patients, for which a patient can transfer from the nontransplanted to the transplanted group. Alternative procedures are given in which distinctive groups are defined for each transplant day. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL hypothesis testing
KW - MATHEMATICAL statistics
KW - STATISTICS
KW - HEART transplantation -- Patients
KW - SURVIVAL analysis (Biometry)
KW - BIOMETRY
KW - FAILURE time data analysis
KW - HEART transplantation
N1 - Accession Number: 4607533; Mantel, Nathan 1; Byar, David P. 2; Affiliations: 1: Mathematical statistician, Biometry Branch, National Cancer Institute, Bethesds, Md. 20014.; 2: Head of the Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, Bethesds, Md. 20014.; Issue Info: Mar1974, Vol. 69 Issue 345, p81; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICS; Subject Term: HEART transplantation -- Patients; Subject Term: SURVIVAL analysis (Biometry); Subject Term: BIOMETRY; Subject Term: FAILURE time data analysis; Subject Term: HEART transplantation; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Bartko, John J.
T1 - Introduction to Linear Models (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/03//
VL - 69
IS - 345
M3 - Book Review
SP - 277
SN - 01621459
AB - Reviews the book "Introduction to Linear Models," by Joe H. Ward Jr. and Earl Jennings.
KW - LINEAR models (Statistics)
KW - NONFICTION
KW - WARD, Joe
KW - WARD, Joe H.
KW - JENNINGS, Earl
KW - INTRODUCTION to Linear Models (Book)
N1 - Accession Number: 4609214; Bartko, John J. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Mar1974, Vol. 69 Issue 345, p277; Thesaurus Term: LINEAR models (Statistics); Subject Term: NONFICTION; Reviews & Products: INTRODUCTION to Linear Models (Book); People: WARD, Joe; People: WARD, Joe H.; People: JENNINGS, Earl; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Goldberger, Robert F.
T1 - Autogenous Regulation of Gene Expression.
JO - Science
JF - Science
Y1 - 1974/03//3/ 1/1974
VL - 183
IS - 4127
M3 - Article
SP - 810
EP - 816
SN - 00368075
N1 - Accession Number: 85345126; Goldberger, Robert F. 1; Affiliations: 1: Chief of Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 1/1974, Vol. 183 Issue 4127, p810; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEWIS, BRIAN J.
AU - ABRELL, JOHN W.
AU - SMITH, R. GRAHAM
AU - GALLO, ROBERT C.
T1 - Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase.
JO - Science
JF - Science
Y1 - 1974/03//3/ 1/1974
VL - 183
IS - 4127
M3 - Article
SP - 867
EP - 869
SN - 00368075
AB - DNA polymrlerase III is ani enzymle activity in eukaryotic cells which under certain conditions shows stronzg preference for polyadetnylic acid as tenzplate when primed by oligodeoxythymnidylate. Its first complete separationt from other DNA polymerases in huemanz lymnphoblasts is reported. This enzyme is biochemically and immunologically distinct from DNA polymerase I and from viral reverse transcriptase from a primate type C virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345152; LEWIS, BRIAN J. 1; ABRELL, JOHN W. 1; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/ 1/1974, Vol. 183 Issue 4127, p867; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenberg, Morris
T1 - DISCRIMINATION, PERSONALITY AND ACHIEVEMENT: A SURVEY OF NORTHERN BLACKS (Book).
JO - Social Forces
JF - Social Forces
Y1 - 1974/03//
VL - 52
IS - 3
M3 - Book Review
SP - 424
EP - 425
PB - Oxford University Press / USA
SN - 00377732
N1 - Accession Number: 13522500; Rosenberg, Morris 1; Affiliation: 1: National Institute of Mental Health; Source Info: Mar74, Vol. 52 Issue 3, p424; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-11237-001
AN - 2009-11237-001
AU - Bouthilet, Lorraine
T1 - 'A place in the country': Dr. Bouthilet replies.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1974///Spr 1974
VL - 1
IS - 8
SP - 5
EP - 5
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11237-001. Partial author list: First Author & Affiliation: Bouthilet, Lorraine; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Facility Environment; Psychiatric Hospitals; Therapeutic Environment. Minor Descriptor: Rural Environments. Classification: Inpatient & Hospital Services (3379). Page Count: 1. Issue Publication Date: Spr 1974.
AB - The current author would like to that Dr. Elinson (see record [rid]2009-11239-001[/rid]) and Dr. Rubin (see record [rid]2009-11238-001[/rid]) for their comments on her original article (see record [rid]2009-11214-001[/rid]). While agreeing with Dr. Rubin that research should receive the highest priority in mental health funding, her main point was that, until we do know more about etiology and effective treatment for schizophrenia, we can perhaps provide a more humane atmosphere in service organizations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental hospitals
KW - state institutions
KW - asylums
KW - facility conversion
KW - reuse
KW - repurposing
KW - 1974
KW - Facility Environment
KW - Psychiatric Hospitals
KW - Therapeutic Environment
KW - Rural Environments
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11233-001
AN - 2009-11233-001
AU - Rosenthal, David
T1 - Introduction to Manfred Bleuler’s 'The offspring of schizophrenics'.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1974///Spr 1974
VL - 1
IS - 8
SP - 91
EP - 92
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11233-001. Partial author list: First Author & Affiliation: Rosenthal, David; Laboratory of Psychology, Division of Clinical, Behavioral, and Biological Research, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Offspring; Schizophrenia. Minor Descriptor: Experimentation. Classification: Schizophrenia & Psychotic States (3213). Page Count: 2. Issue Publication Date: Spr 1974.
AB - This article introduces Manfred Bleuler and his work 'The offspring of Schizophrenics' which is unique work in the field of psychiatry. From a research standpoint, he has: specified his criteria for the diagnosis of schizophrenia clearly and thoroughly; developed a most useful method for representing clinical course graphically; assessed course and outcome in schizophrenia more definitely than it has ever been done before, with many new insights; compared acute and chronic schizophrenia; evaluated the impact of schizophrenic parents on their children at different ages, the social relationships at home, and the impact of IQ and social class level in a way that has never been done before; compared proband sibs with proband offspring in a unique analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Manfred Bleuler
KW - The offspring of schizophrenia
KW - schizophrenia research
KW - 1974
KW - Offspring
KW - Schizophrenia
KW - Experimentation
KW - 1974
DO - 10.1093/schbul/1.8.91
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Stadtman, Thressa C.
T1 - Selenium Biochemistry.
JO - Science
JF - Science
Y1 - 1974/03/08/
VL - 183
IS - 4128
M3 - Article
SP - 915
EP - 922
SN - 00368075
N1 - Accession Number: 85345164; Stadtman, Thressa C. 1; Affiliations: 1: Biochemist, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/ 8/1974, Vol. 183 Issue 4128, p915; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARSTAD, P.
AU - RUDIKOFF, S.
AU - POTTER, M.
AU - COHN, M.
AU - KONIGSBERG, W.
AU - HOOD, L.
T1 - Imunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine.
JO - Science
JF - Science
Y1 - 1974/03/08/
VL - 183
IS - 4128
M3 - Article
SP - 962
EP - 964
SN - 00368075
AB - The amino terminal sequences of five light and heavy immunoglobulin chains from myeloma proteins of the BALBIc mouse with binding activity to phosphorylcholine are presented. Except for a single substitution in position 4, all five heavy chains have identical amino terminal sequences through the first hypervariable region. Proteins which share unique (idiotypic) antigenic determinants are identical through the first hypervariable region of their light and heavy chains. Proteins with differing idiotypic determinants have light chains of differing amino acid sequence. These observations suggest that the heavy chain plays a more important role than the light chain in determining the phosphorylcholine binding site. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345189; BARSTAD, P. 1; RUDIKOFF, S. 2; POTTER, M. 2; COHN, M. 3; KONIGSBERG, W. 4; HOOD, L. 5; Affiliations: 1: Division of Biology, California Institute of Technology, Pasadena 91109; 2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Salk Institute for Biological Studies, San Diego, California 92112; 4: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510; 5: Division of Biology, California Instituite of Technology; Issue Info: 3/ 8/1974, Vol. 183 Issue 4128, p962; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FEARS, THOMAS R.
AU - SCHNEIDERMAN, MARVIN A.
T1 - Pathologic Evaluation and the Blind Technique.
JO - Science
JF - Science
Y1 - 1974/03/22/
VL - 183
IS - 4130
M3 - Article
SP - 1143
EP - 1144
SN - 00368075
N1 - Accession Number: 85345242; FEARS, THOMAS R. 1; SCHNEIDERMAN, MARVIN A. 1; Affiliations: 1: National Institutes of Health, Nationa Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/22/1974, Vol. 183 Issue 4130, p1143; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - COSMIDES, GEORGE J.
T1 - Pharmacology and Toxicology Applied to the Treatment of Patients.
JO - Science
JF - Science
Y1 - 1974/03/22/
VL - 183
IS - 4130
M3 - Article
SP - 1219
EP - 1221
SN - 00368075
N1 - Accession Number: 85345277; COSMIDES, GEORGE J. 1; Affiliations: 1: National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 3/22/1974, Vol. 183 Issue 4130, p1219; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kleinman, L. M.;
AU - Tangrea, J. A.;
AU - Gallelli, J. P.;
T1 - Control of investigational drugs in a research hospital
CT - Control of investigational drugs in a research hospital
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1974/04/01/
VL - 31
IS - Apr
SP - 368
EP - 371
SN - 00029289
AD - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-2571; Language: English; References: 2; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - The responsibilities of the clinical investigator and the pharmacy department for investigational drugs at the Clinical Center, National Institutes of Health, are described. Procedures for review of research protocol, product formulation, logistics of distribution, and control and accountability for drug use are presented. Control of investigational drugs by the pharmacy department decreases the likelihood of unauthorized use and assures more complete and accessible patient drug records.
KW - Drugs, investigational--control--pharmacists, role, in research hospital;
KW - Control--drugs, investigational--pharmacists, role, in research hospital;
KW - Pharmacists, hospital--drugs, investigational--control, in research hospital;
KW - Pharmacy, institutional, hospital--drug information--drugs, investigational, control, role of pharmacist;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ablon, S. L.;
AU - Goodwin, F. K.;
T1 - High frequency of dysphoric reaction to tetrahydrocannabinol among depressed patients
CT - High frequency of dysphoric reaction to tetrahydrocannabinol among depressed patients
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1974/04/01/
VL - 131
IS - Apr
SP - 448
EP - 453
SN - 0002953X
AD - Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-1468; Language: English; Therapeutic Class: (28:16.04); AHFS Class: Antidepressants tetrahydrocannabinol; References: 35; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: C. Robert Sturwold
N2 - A high incidence of dysphoric reactions to delta-9-tetrahydrocannabinol (I) administered under double blind conditions to a homogeneous population of 8 unipolar and 5 bipolar depressed hospitalized patients is reported. Patients received I tablets in a sesame oil vehicle in doses ranging from 5 mg. orally once a day to 20 mg. orally twice daily for 1 to 7 days. All patients were rated twice daily for depression, mania, anxiety, psychosis, anger, and dysphoria. Six of the 8 unipolar patients had dysphoric reactions to I, while only 1 of 5 bipolar had similar experiences. Based on the final evaluations, it was suggested that I be classified as a mood intensifier rather than as an euphoriant. Case studies are presented.
KW - Tetrahydrocannabinol--antidepressants-;
KW - Antidepressants--tetrahydrocannabinol--tablets, effects, in unipolar and bipolar patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Wittman, Milton
T1 - Social Work Manpower for the Health Services: Problems and Prospects.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/04//
VL - 64
IS - 4
M3 - Article
SP - 370
EP - 375
PB - American Public Health Association
SN - 00900036
AB - The article discusses the issues concerning the training and deployment of social work manpower in the U.S. Manpower problems involved in providing health and medical care services to the total population of the country has, for the first, been recognized by health professionals, the consumers of services and policy-makers. Another concern in the country's health system is the significant changes in the organization and structure of the health and mental health services, which will have great impact on the ultimate delivery of service.
KW - Public health
KW - UNITED States
KW - Labor supply
KW - Social workers -- United States
KW - Human services personnel
KW - Medical care -- United States
KW - Consumers -- United States
KW - Mental health services
KW - Social services
KW - United States
N1 - Accession Number: 7971160; Wittman, Milton 1; Affiliations: 1: Chief, Social Work Training Branch, Division of Manpower and Training Programs, National Institute of Mental Health, Alcoholism, Drug Abuse, and Mental Health Administration, U.S. Department of Health, Education, and Welfare. Rockville, Maryland 20852; Issue Info: Apr1974, Vol. 64 Issue 4, p370; Thesaurus Term: Public health; Subject Term: UNITED States; Subject Term: Labor supply; Subject Term: Social workers -- United States; Subject Term: Human services personnel; Subject Term: Medical care -- United States; Subject Term: Consumers -- United States; Subject Term: Mental health services; Subject Term: Social services; Subject: United States; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Galanter, M.;
AU - Stillman, R.;
AU - Wyatt, R. J.;
AU - Vaughan, T. B.;
AU - Weingartner, H.;
AU - \ET/;
T1 - Marihuana and social behavior
CT - Marihuana and social behavior
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/04/01/
VL - 30
IS - Apr
SP - 518
EP - 521
AD - Reprints: Albert Einstein College of Medicine, Bronx Municipal Hospital Center, Dept. of Psychiatry, Jacobi Hospital, Rm. 118, Bronx, New York 10461
AD - Laboratory of Clinical Psychopharmacology of the National Institute of Mental Health, Washington, D.C.
N1 - Accession Number: 12-5621; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 23; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - In a study of 36 unpaid volunteer subjects who were experienced marihuana users, marihuana (cannabis) was found to act as a mild psychotomimetic.
KW - Cannabis--effects-;
KW - Drug abuse--cannabis--effects, psychotomimetic, in users;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lee, R. C. T.
AU - Chang, C. L.
AU - Waldinger, R. J.
AU - Standish, T. A.
T1 - An Improved Program-Synthesizing Algorithm and Its Correctness.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1974/04//
VL - 17
IS - 4
M3 - Article
SP - 211
EP - 217
SN - 00010782
AB - An improved program-synthesizing algorithm based on the algorithm proposed by Waldinger and Lee in 1969 is given In the old algorithm, the program-synthesizing problem is translated into a theorem-proving problem, and a program is obtained by analyzing a proof. For the improved algorithm, the analysis is not necessary, and a program is obtained as soon as the proof is completed. This is achieved by using a modified variable tracing mechanism invented by Green in 1969. The correctness of the Improved algorithm is also proved; i.e. the program thus obtained always satisfies the specification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER algorithms
KW - ONLINE algorithms
KW - COMPUTER programming
KW - ELECTRONIC data processing
KW - MATHEMATICAL analysis
KW - PROGRAMMING languages (Electronic computers)
KW - consequence finding
KW - primitive resolutions
KW - program-synthesizing algorithms
KW - theorem proving
N1 - Accession Number: 5225220; Lee, R. C. T. 1 Chang, C. L. 1 Waldinger, R. J. 2 Standish, T. A.; Affiliation: 1: Heuristics Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20014. 2: Stanford Research Institute, Menlo Park, CA 94025.; Source Info: Apr1974, Vol. 17 Issue 4, p211; Subject Term: COMPUTER algorithms; Subject Term: ONLINE algorithms; Subject Term: COMPUTER programming; Subject Term: ELECTRONIC data processing; Subject Term: MATHEMATICAL analysis; Subject Term: PROGRAMMING languages (Electronic computers); Author-Supplied Keyword: consequence finding; Author-Supplied Keyword: primitive resolutions; Author-Supplied Keyword: program-synthesizing algorithms; Author-Supplied Keyword: theorem proving; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541519 Other Computer Related Services; NAICS/Industry Codes: 511210 Software Publishers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); Number of Pages: 7p; Illustrations: 12 Diagrams; Document Type: Article
L3 - 10.1145/360924.360967
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young-Cooper, Glendowlyn O.
AU - Mage, Rose G.
T1 - Neutralization of Allotype Suppression in Rabbits.
JO - Immunology
JF - Immunology
Y1 - 1974/04//
VL - 26
IS - 4
M3 - Article
SP - 809
EP - 817
PB - Wiley-Blackwell
SN - 00192805
AB - Data are presented which show that allotype suppression by maternal antibody can be neutralized either by foster nursing or by intraperitoneal injections of serum with paternal allotype and that the phenomenon occurs with allotypes of both the a and b loci. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN allotypes
KW - IMMUNOGENETICS
KW - GENETIC polymorphisms
KW - SERUM
KW - INTRAPERITONEAL injections
KW - IMMUNOGLOBULINS
N1 - Accession Number: 12826278; Young-Cooper, Glendowlyn O. 1 Mage, Rose G. 1; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of health. Bethesda, Maryland 20014, U.S.A.; Source Info: Apr74, Vol. 26 Issue 4, p809; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: IMMUNOGENETICS; Subject Term: GENETIC polymorphisms; Subject Term: SERUM; Subject Term: INTRAPERITONEAL injections; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Balter, M. B.;
AU - Levine, J.;
AU - Manheimer, D. I.;
T1 - Cross-national study of the extent of anti-anxiety/sedative drug use
CT - Cross-national study of the extent of anti-anxiety/sedative drug use
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/04/04/
VL - 290
IS - Apr 4
SP - 769
EP - 774
SN - 00284793
AD - Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852
N1 - Accession Number: 11-4061; Language: English; References: 6; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics
N2 - National samples of respondents in 9 Western European countries were asked identical questions about their use of anti-anxiety/sedative drugs during the past year and about their general attitude toward tranquilizers. The 9 countries in which the surveys were carried out were Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. The proportion of persons who used anti-anxiety/sedative drugs on 1 or more occasions varied from 17% in Belgium and France to 10% in Spain. In almost every country the percentage of females who had used anti-anxiety/sedative drugs was approximately twice that of males. Persons 45 years of age and over were over-represented among drug users in all countries in relation to their presence in the national population. The rank order of the countries on attitude toward tranquilizers was poorly correlated with rank order on use rates. However, within each country there was a sharp difference in attitude between users and nonusers. Independent data place the United States in a middle position among the 9 countries surveyed on use of anti-anxiety/sedative drugs.
KW - Sedatives and hypnotics--use--statistics, patients, Europe;
KW - Psychotherapeutic agents--use--statistics, patients, Europe;
KW - Tranquilizers--use--statistics, patients, Europe;
KW - Statistics--sedatives and hypnotics--use, patients, Europe;
KW - Statistics--psychotherapeutic agents--use, patients, Europe;
KW - Statistics--tranquilizers--use, patients, Europe;
KW - Europe--psychotherapeutic agents--use, patients, statistics;
KW - Europe--tranquilizers--use, patients, statistics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PURCELL, ROBERT H.
T1 - Hepatitis Research.
JO - Science
JF - Science
Y1 - 1974/04/05/
VL - 184
IS - 4132
M3 - Article
SP - 9
EP - 9
SN - 00368075
N1 - Accession Number: 85345319; PURCELL, ROBERT H. 1,2; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy, Bethesda, Maryland 20014; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p9; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bourne, H. R.
AU - Lichtenstein, L. M.
AU - Melmon, K. L.
AU - Henney, C. S.
AU - Weinstein, Y.
AU - Shearerq, G. M.
T1 - Modulation of Inflammation and Immunity by Cyclic AMP.
JO - Science
JF - Science
Y1 - 1974/04/05/
VL - 184
IS - 4132
M3 - Article
SP - 19
EP - 28
SN - 00368075
N1 - Accession Number: 85345322; Bourne, H. R. 1,2; Lichtenstein, L. M. 3; Melmon, K. L. 1,2; Henney, C. S. 3; Weinstein, Y. 1,2; Shearerq, G. M. 4; Affiliations: 1: Member, Department of Medicine, Division of Clinical Pharmacology, University of California Medical Center, San Francisco, California 94143; 2: Member, Department of pharmacology, Division of Clinical Pharmacology, University of California Medical Center, San Francisco, California 94143; 3: Member, Division of Immunology, Good Samaritan Hospital, Johns Hopkins University, Baltimore, Maryland 21239; 4: Member, Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p19; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DRISCOLL, BERNARD F.
AU - KRAMER, ALLAN J.
AU - KIES, MARIAN W.
T1 - Myelin Basic Protein: Location of Multiple Independent Antigenic Regions.
JO - Science
JF - Science
Y1 - 1974/04/05/
VL - 184
IS - 4132
M3 - Article
SP - 73
EP - 75
SN - 00368075
AB - Immnunization of guinea pigs with homologous myelin basic protein induces antibodies that differ in their ability to bind specific peptide fragments of the protein. Antiserums with differing specificities made it possible to demonstrate at least three mutually exclusive antigenic sites in the protein mnolecule. One of these sites is located between residues 44 and 89, another between 90 and 116, and the third between 117 and 170. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345347; DRISCOLL, BERNARD F. 1; KRAMER, ALLAN J. 1; KIES, MARIAN W. 1; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p73; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAY, VERNON L.
AU - TOMACARI, R. L.
T1 - Follicle-Stimulating Hormone Secretion in the Female Rat: Cyclic Release Is Dependent on Circulating Androgen.
JO - Science
JF - Science
Y1 - 1974/04/05/
VL - 184
IS - 4132
M3 - Article
SP - 75
EP - 77
SN - 00368075
AB - In adult cyclic female rats, intravenous injections of an antiserum to testosterone prevented the continued increase in serum follicle-stimulating hormone (FSH) which normally occurs during the early morning hours of estrus. This treatment did not prevent the initial increases in serum FSH (and luteinizing hormone) which occur during the critical period (1400 to 2000 of proestrus), nor did it interfere with subsequent ovulation. These observations indicate the existence of two separate mechanisms for preovulatory FSH release in the rat and implicate circulating testosterone as FSH during estrus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345348; GAY, VERNON L. 1,2; TOMACARI, R. L. 1; Affiliations: 1: Department of Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261; 2: Career Development awardee, National Institute of Child Health and Human Development; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p75; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - OKA, TAKAMI
T1 - Spermidine in Hormone-Dependent Differentiation of Mammary Gland in vitro.
JO - Science
JF - Science
Y1 - 1974/04/05/
VL - 184
IS - 4132
M3 - Article
SP - 78
EP - 80
SN - 00368075
AB - Stimulation of milk-protein synthesis in mouse mammary epithelium in vitro requires insulin, hydrocortisone, and prolactin. The requirement for hydrocortisone can be replaced by spertmidine. The possibility that spermidine mediates the effect of glucocorticoid is also supported by the observation that the cellular spermidine concentration increases before the accelerated synthesis of casein and α-lactalbumin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345350; OKA, TAKAMI 1,2; Affiliations: 1: National Institute of Arthritis, Metabolism, Maryland 20014; 2: Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 5/1974, Vol. 184 Issue 4132, p78; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PARKS, WADE P.
AU - SCOLNICK, EDWARD M.
AU - KOZIKOWSKI, EDMUND H.
T1 - Dexamethasone Stimulation of Murine Mammary Tumor Virus Expression: A Tissue Culture Source of Virus.
JO - Science
JF - Science
Y1 - 1974/04/12/
VL - 184
IS - 4133
M3 - Article
SP - 158
EP - 160
SN - 00368075
AB - In mouse cell lines derived from mammary adenocarcinomnas, the synthetic steroid dexamnethasone stimulates production of murine mamnmary tumor virus. Viral RNA and antigens are increased as much as 20-fold, and culture fluid supernatants froml steroid-treated cells contain type B particles with reverse transcriptase. These cells provide a possible tissue culture source of this virus and a model system for studying the mechanism of action of corticosteroids and the regulation of transcription of integrated viral DNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345387; PARKS, WADE P. 1; SCOLNICK, EDWARD M. 1; KOZIKOWSKI, EDMUND H. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Meloy Laboratories, Rockville, Maryland 20850; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p158; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BROWNSTEIN, MICHAEL
AU - AXELROD, JULIUS
T1 - Pineal Gland: 24-Hour Rhythm in Norepinephrine Turnover.
JO - Science
JF - Science
Y1 - 1974/04/12/
VL - 184
IS - 4133
M3 - Article
SP - 163
EP - 165
SN - 00368075
AB - There is a 24-hour rhythm in the turnover of norepinephrine in sympathetic nerves innervating the pineal gland. This rhythm persists in blinded animals but is suppressed in normnal rats by light. The rhythm in norepinephrine turnover generates the rhythins in pineal indoleamines and N-acetyltransferase. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345390; BROWNSTEIN, MICHAEL; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p163; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SELKIRK, JAMES K.
AU - CROY, ROBERT G.
AU - GELBOIN, HARRY V.
T1 - Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography.
JO - Science
JF - Science
Y1 - 1974/04/12/
VL - 184
IS - 4133
M3 - Article
SP - 169
EP - 171
SN - 00368075
AB - High-pressure liquid chromatography can separate eight metabolites of benzo[a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345393; SELKIRK, JAMES K. 1; CROY, ROBERT G. 1; GELBOIN, HARRY V. 1; Affiliations: 1: Molecular Carcinogenesis Section, Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/12/1974, Vol. 184 Issue 4133, p169; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steinhart, John S.
AU - Steinhart, Carol E.
T1 - Energy Use in the U.S. Food System.
JO - Science
JF - Science
Y1 - 1974/04/19/
VL - 184
IS - 4134
M3 - Article
SP - 307
EP - 316
SN - 00368075
N1 - Accession Number: 85345422; Steinhart, John S. 1,2; Steinhart, Carol E. 3; Affiliations: 1: Professor of geology and geophysics, University of Wisconsin Madison; 2: Professor, Institute for Environmental Studies, University of Wisconsin Madison; 3: Formerly a biologist, National Institutes of Health, Science writer and editor; Issue Info: 4/19/1974, Vol. 184 Issue 4134, p307; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Carman, J. S.;
AU - Shoulson, I.;
AU - Chase, T. N.;
T1 - Huntington's chorea treated with lithium carbonate
CT - Huntington's chorea treated with lithium carbonate
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1974/04/27/
VL - 1
IS - Apr 27
SP - 811
SN - 00237507
AD - Neurology Unit, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-4175; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents lithium carbonate; References: 3; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - No improvement in motor or cognitive function occurred in any of 6 patients with Huntington's chorea treated with lithium carbonate. There was an apparent worsening of motor and cognitive performance during the first 4 to 7 days of lithium treatment and during a similar period immediately following lithium withdrawal. This functional deterioration was accompanied by a transient decline in serum-calcium levels in each of the 3 patients in whom these measurements were made.
KW - Lithium carbonate--Huntington's disease-;
KW - Antiparkinson agents--lithium carbonate--Huntington's disease;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hardesty, C.;
AU - Chaney, N.;
AU - Waravdekar, V.;
AU - Mead, J.;
T1 - Disposition of the antitumor agent, sangivamycin, in mice
CT - Disposition of the antitumor agent, sangivamycin, in mice
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1974/05/01/
VL - 34
IS - May
SP - 1005
EP - 1009
SN - 00085472
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-4506; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents sangivamycin; References: 17; Journal Coden: CNREA8; Section Heading: Drug Metabolism and Body Distribution; Preliminary Drug Testing
N2 - In vivo studies established that sangivamycin (I) is phosphorylated and incorporated into the nucleic acids of mouse tissues. When radiolabeled I was administered to mice IP, the major component of drug in liver, heart, brain, and red blood cells was I 5\PR/-monophosphate; whereas, in spleen and kidney, the larger proportion of the drug was recovered as unmetabolized I. Small amounts of I 5\PR/-diphosphate were identified in all tissues, but I 5\PR/-triphosphate was detected only in red blood cells. There was incorporation of I into RNA and DNA of all tissues except brain, where labeling occurred only in RNA. The half-life of I in mouse blood was 50 hr after IP injection. Labeled I was retained in tissues for at least 12 days, presumably because of its intracellular phosphorylation. The main route of excretion appeared to be the kidneys; 40% of the drug-derived radioactivity was accounted for in the urine over a period of 12 days.
KW - Sangivamycin--metabolism-;
KW - Antineoplastic agents--sangivamycin--body distribution, and metabolism, in mice;
KW - Blood levels--sangivamycin--half-life, and body distribution, in mice;
KW - Tissue levels--sangivamycin--in mice;
KW - Metabolism--sangivamycin--body distribution, in mice;
KW - Drugs, body distribution--sangivamycin--in mice;
KW - Half-life--sangivamycin--blood levels, and body distribution, in mice;
KW - Excretion--sangivamycin--body distribution, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gorodetzky, C. W.;
AU - Angel, C. R.;
AU - Beach, D. J.;
AU - Catlin, D. H.;
AU - Yeh, S.;
T1 - Validity of screening methods for drugs of abuse in biological fluids. 1. Heroin in urine
CT - Validity of screening methods for drugs of abuse in biological fluids. 1. Heroin in urine
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/05/01/
VL - 15
IS - May
SP - 461
EP - 472
SN - 00099236
AD - National Institute on Drug Abuse Addiction Research Center, Lexington, Kentucky and Walter Reed Army Institute of Research, Div. of Biochemistry and Medicine, Washington, D.C.
N1 - Accession Number: 12-5961; Language: English; Trade Name: Heroin; Generic Name: Diacetylmorphine; Chemical Name: Diacetylmorphine--561-27-3; References: 26; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Methodology; Drug Analysis
N2 - To evaluate several methods of detecting heroin (diacetylmorphine) use by urine analysis for morphine and its metabolites, single IV doses of 2.5 and 5 mg/70 kg were administered a week apart in random order to 10 nontolerant subjects and their urine was collected for the week following. Along with pre-drug control urines, each sample was coded, randomized, and analyzed under blind conditions by the following methods: (1) thin layer chromatography with iodoplatinate preceded by each of 4 extraction procedures, organic solvent and ion exchange resin impregnated paper extraction both without and with prior acid hydrolysis; (2) the free radical assay technique; (3) radioimmunoassay; and (4) the Technicon Autoanalyzer. There was a high probability of detection for the first 8 hours by all methods except 4 (which gave a low proportion of positives 8 hours after the 2.5 mg/70 kg dose); up to 16 hours with 1 and 2; and up to 32 to 48 hours with 3.
KW - Diacetylmorphine--methodology-;
KW - Methodology--diacetylmorphine--excretion, urinary, detection, in humans;
KW - Excretion--diacetylmorphine--urinary, detection, methodology, in patients;
KW - Dependence--diacetylmorphine--excretion, urinary, detection, methodology, in humans;
KW - Chromatography, thin layer--diacetylmorphine--excretion, urinary, compared to other methodologies, in humans;
KW - Radioimmunoassay--diacetylmorphine--excretion, urinary, compared to other methodologies, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - King Jr., L. E.
AU - Florendo, N. T.
AU - Solomon, S. S.
AU - Hashimoto, K.
T1 - CYCLIC 3', 5'-NUCLEOTIDE PHOSPHODIESTERASE I. HISTOCHEMICAL LOCALIZATION IN RAT SKIN.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/05//
VL - 62
IS - 5
M3 - Article
SP - 485
EP - 492
SN - 0022202X
AB - The distribution of cyclic 3' ,5'-nucleotide phosphodiesterase activity in albino rat skin was studied by histochemical methods. The demonstrable enzymatic activity was found on or near the plasma membranes of mast cells, dermal fibroblasts, epidermal keratinocytes, and basal dendritic cells. Plasma membranes of endothelial cells and intravascular erythrocytes and leukocytes also were labeled, but the enzymatic activity of the plasma itself may have produced this labeling. Theophylline. a phosphodiesterase inhibitor, blocked the formation of demonstrable enzymatic products from exogenous cyclic AMP in rat skin. These histochemical studies show that cyclic AMP phosphodiesterase occurs in most, if not all, skin cell types. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLIC nucleotide phosphodiesterases
KW - NUCLEOTIDES
KW - NUCLEIC acids
KW - BLOOD plasma
KW - ERYTHROCYTES
KW - LEUCOCYTES
N1 - Accession Number: 12681001; King Jr., L. E. 1 Florendo, N. T. Solomon, S. S. 2 Hashimoto, K. 3; Affiliation: 1: Advanced Specially Training Program in Dermatology and Research Funds, Veterans Administration 2: NIAMD, National Institutes of Health 3: Medical Investigator Award and Research Funds, Veterans Administration; Source Info: May74, Vol. 62 Issue 5, p485; Subject Term: CYCLIC nucleotide phosphodiesterases; Subject Term: NUCLEOTIDES; Subject Term: NUCLEIC acids; Subject Term: BLOOD plasma; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12681001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06262-019
AN - 2006-06262-019
AU - Phillipson, Richard
T1 - Methadone Maintenance, 'A Passing Affair'.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1974/05//
VL - 19
IS - 5
SP - 381
EP - 382
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06262-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Phillipson, Richard; National Institute of Drug Abuse, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Rehabilitation; Methadone Maintenance; Narcotic Drugs; Social Issues; Treatment. Minor Descriptor: Methadone. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Nelkin, Dorothy. Methadone Maintenance: A Technological Fix=New York: Braziller, 1973. Pp. ix + 164. $6.95 cloth; $1.95 paper; 1973. Page Count: 2. Issue Publication Date: May, 1974.
AB - Reviews the book, Methadone Maintenance: A Technological Fix by Dorothy Nelkin (1973). The author claims that the study is not intended as an evaluation of the Syracuse methadone treatment program nor is it a judgment of the overall merits of methadone maintenance; it sets out to describe methadone maintenance as a social phenomenon and the implications of the increasing tendency to seek technological solutions to major social problems. In the opening chapter, 'The Addict and Society,' the author criticizes the paucity of provision for aftercare services in treatment programs of the National Institute of Mental Health. Chapter 2 addresses methadone maintenance. The author spells out the pro's and con's of the very controversial method of 'chemotherapeutic constraint' with admirable clarity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methadone maintenance
KW - treatment program
KW - synthetic narcotic
KW - social phenomena
KW - social problems
KW - technological solutions
KW - chemotherapeutic constraint
KW - 1974
KW - Drug Rehabilitation
KW - Methadone Maintenance
KW - Narcotic Drugs
KW - Social Issues
KW - Treatment
KW - Methadone
KW - 1974
U2 - Nelkin, Dorothy. (1973); Methadone Maintenance: A Technological Fix; New York: Braziller, 1973. Pp. ix + 164. $6.95 cloth; $1.95 paper
DO - 10.1037/0012662
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - MINTON, ALLEN P.
T1 - Oxygen Binding in Cyanmet Hybrid and Normal Hemoglobins: Applicability of Sequential and Two-State Concerted Models.
JO - Science
JF - Science
Y1 - 1974/05/03/
VL - 184
IS - 4136
M3 - Article
SP - 577
EP - 579
SN - 00368075
AB - The cyanmet hybrid hemoglobins ajj8+CN2 and a+ONg2,/32 are widely held to be similar or equivalent in structure and subunit interactions to the partially oxygen-liganded species %2(? * 02)2 and (a' 02)2/,82 respectively. An analysis of precise data on oxygen binding to the cyanmet hybrids and normal hemoglobin shows that if this is the case, then cooperative ligand binding in hemoglobin is more properly described by some model of the sequential type than by any twostate concerted model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345507; MINTON, ALLEN P. 1; Affiliations: 1: Laboratory of Biophysical Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/ 3/1974, Vol. 184 Issue 4136, p577; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WHITNEY JR., ROBERT A.
T1 - Ectromelia in U.S. Mouse Colonies.
JO - Science
JF - Science
Y1 - 1974/05/10/
VL - 184
IS - 4137
M3 - Article
SP - 609
EP - 609
SN - 00368075
N1 - Accession Number: 85345514; WHITNEY JR., ROBERT A. 1; Affiliations: 1: Veterinary Resources Branch, Division of Research Services, Public Health Service, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/10/1974, Vol. 184 Issue 4137, p609; Number of Pages: 2/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Masson, T. J.;
AU - McKay, F. W.;
AU - Miller, R. W.;
T1 - Asbestos-like fibers in Duluth water supply: relation to cancer mortality
CT - Asbestos-like fibers in Duluth water supply: relation to cancer mortality
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1974/05/20/
VL - 228
IS - May 20
SP - 1019
EP - 1020
AD - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-3838; Language: English; Chemical Name: Asbestos--1332-21-4; References: 6; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - Studies of the carcinogenic effect of asbestos-like fibers found in the water supply of Duluth in 1955, is presented. The 14 year study showed no apparent carcinogenic effect in the patterns of cancer mortality among persons of all ages, nor among children. The period of observation is short relative to the latent period for occupationally induced carcinogenesis from asbestos.
KW - Asbestos--toxicity, environmental-;
KW - Toxicity, environmental--asbestos--lack, carcinogenic effect, after fiber detection in water supply, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mackie, James B.
AU - Lloyd, Dee N.
AU - Rafferty, Frank
T1 - The Father's Influence on the Intellectual Level of Black Ghetto Children.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/06//
VL - 64
IS - 6
M3 - Article
SP - 615
EP - 616
PB - American Public Health Association
SN - 00900036
AB - The article investigates the father's influence on the intellectual level of Black ghetto children in the U.S. National interest has shifted on black ghetto children, especially upon their educational achievement and relationships between that achievement and family background on one hand and new educational programs on the other. Particular efforts have been made to identify a constellation of family variables that may account for a documented gap between the level of intellectual skills shown by these children and the level shown by white, middle class children of the same age.
KW - African American children
KW - Academic achievement
KW - Father & child
KW - Child development
KW - Family relations
KW - Ethnic neighborhoods
KW - Inner cities
KW - Ethnic groups
KW - United States
N1 - Accession Number: 7971227; Mackie, James B. 1,2; Lloyd, Dee N. 3; Rafferty, Frank 4,5,6; Affiliations: 1: Associate Professor, Clinical Psychology Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School, Baltimore, Maryland 21201; 2: Director, Clinical Psychology Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School, Baltimore, Maryland 21201; 3: Research Psychologist, Mental Health Study Center, National Institute of Mental Health, Department of Health, Education, Welfare, Adelphi, Maryland 20783; 4: Professor, Child Psychiatry Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School; 5: Director, Child Psychiatry Division, Institute of Psychiatry and Human Behavior, University of Maryland Medical School; 6: Director, Institute for Juvenile Research, Chicago, Illinois 60612; Issue Info: Jun1974, Vol. 64 Issue 6, p615; Subject Term: African American children; Subject Term: Academic achievement; Subject Term: Father & child; Subject Term: Child development; Subject Term: Family relations; Subject Term: Ethnic neighborhoods; Subject Term: Inner cities; Subject Term: Ethnic groups; Subject: United States; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Gorodetzky, C. W.;
AU - Kullberg, M. P.;
T1 - Validity of screening methods for drugs of abuse in biological fluids. 2. Heroin in plasma and saliva
CT - Validity of screening methods for drugs of abuse in biological fluids. 2. Heroin in plasma and saliva
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/06/01/
VL - 15
IS - Jun
SP - 579
EP - 587
SN - 00099236
AD - National Institute on Drug Abuse Addiction Research Center and Univ. of Kentucky College of Medicine, Dept. of Psychiatry, Lexington, Kentucky
N1 - Accession Number: 12-6622; Language: English; Chemical Name: Diacetylmorphine--561-27-3 Dextromethorphan--125-71-3 Morphine--57-27-2; Therapeutic Class: (48:00); AHFS Class: Expectorants and cough preparations dextromethorphan (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2 - Assay techniques for the determination of single doses of heroin (diacetylmorphine; I) and dextromethorphan (II) and multiple doses of morphine (III) in humans were studied. Single intravenous doses of I, 2.5, 5 and 10 mg/70 kg were given to 5 subjects; one subject received II, 60 mg/70 kg orally and 4 subjects received III, 30 mg, SC 4 times daily for 3 months. Saliva and plasma samples were collected at intervals for 48 hr following each single drug dose and hourly for 6 hr between chronic doses. Plasma samples were analyzed for opiate by radioimmunoassay and saliva samples by radioimmunoassay, free radical assay technique and the homogeneous enzyme immunoassay. The low dose of I was not consistently detectable at any sampling time in either the plasma or the saliva. The medium and high doses were detectable with high probability for 2-4 hr in plasma and 1-2 hr in saliva. II was not detectable in plasma but was detected with high probability in saliva for 30 min by enzyme imunoassay and 2 hr by free radical assay. During chronic administration there were high probabilities of detection of III in plasma for at least 6 hr and in saliva for 3-4 hr after the last III dose. While these fluids do not appear to be as useful as urine in routine screening for I, they may be useful in the detection of high dose chronic abuse.
KW - Diacetylmorphine--methodology-;
KW - Dextromethorphan--methodology-;
KW - Morphine--methodology-;
KW - Methodology--diacetylmorphine--analysis, plasma and saliva, in humans;
KW - Methodology--dextromethorphan--analysis, plasma and saliva, in humans;
KW - Methodology--morphine--analysis, plasma and saliva, in humans;
KW - Expectorants and cough preparations--dextromethorphan--methodology, plasma and saliva analysis, in humans;
KW - Analgesics and antipyretics--morphine--methodology, plasma and saliva analysis, in humans;
KW - Blood levels--diacetylmorphine--methodology, analysis, in humans;
KW - Blood levels--dextromethorphan--methodology, analysis, in humans;
KW - Blood levels--morphine--methodology, analysis, in humans;
KW - Saliva levels--diacetylmorphine--methodology, analysis, in humans;
KW - Saliva levels--dextromethorphan--methodology, analysis, in humans;
KW - Saliva levels--morphine--methodology, analysis, in humans;
KW - Metabolism--diacetylmorphine--blood levels, and saliva levels, analysis, methodology, in humans;
KW - Metabolism--dextromethorphan--blood levels, and saliva levels, analysis, methodology, in humans;
KW - Metabolism--morphine--blood levels, and saliva levels, analysis, methodology, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - Canellos, G. P.;
AU - Chabner, B. A.;
AU - Schein, P. S.;
AU - Brereton, H. D.;
AU - \ET/;
T1 - Treatment of malignant melanoma with methyl CCNU (semustine)
CT - Treatment of malignant melanoma with methyl CCNU (semustine)
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/06/01/
VL - 15
IS - Jun
SP - 617
EP - 622
SN - 00099236
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-6482; Language: English; Trade Name: Methyl-1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; Generic Name: Semustine; Chemical Name: Semustine--13909-09-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents semustine; References: 14; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Twenty-eight patients with disseminated malignant melanoma were treated with semustine (I) administered as a single dose orally every 6 weeks. Six patients (21%) had a complete or partial regression of measurable disease. The median duration of the partial remissions was 2 months and for the one complete remission, 18 months. The median survival of those responding to therapy (10.6 months) was significantly longer than those who failed to respond (4.2 months). Regressions of skin, intracutaneous, and nodal disease were most common, but 4 patients had regression of lung metastasis and one patient had regression of bone metastasis. Toxicity was primarily delayed thrombocytopenia and to a lesser extent leukopenia occurring within 4 to 6 weeks. Hematopoietic toxicity was significant but manageable. The response rate, ease of administration, and absence of sex difference in response make I potentially useful in the chemotherapeutic management of disseminated malignant melanoma.
KW - Semustine--melanomas-;
KW - Antineoplastic agents--semustine--melanomas, malignant, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
AU - Thompson, W. O.;
AU - Fraser, H. F.;
T1 - Comparison of graded single intramuscular doses of morphine and pentobarbital in man
CT - Comparison of graded single intramuscular doses of morphine and pentobarbital in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/06/01/
VL - 15
IS - Jun
SP - 623
EP - 630
SN - 00099236
AD - National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky
N1 - Accession Number: 12-6579; Language: English; Chemical Name: Pentobarbital--76-74-4 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, pentobarbital (28:24); AHFS Class: Sedatives and hypnotics pentobarbital, comparison, morphine; References: 14; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Graded single IM doses of morphine (I) sulfate (8, 16, and 32 mg) and pentobarbital (II) sodium (150, 200, and 250 mg) and a placebo were administered double blind to 12 nontolerant narcotic addicts. To assess the magnitude and time course of subjective effects and associated signs, ""single and chronic dose'' opiate questionnaires were completed by subjects and observers. Objective measurements of drug effect were concurrently made, using photographs of the pupils and the duration of postrotational nystagmus. Overall, the questionnaires showed definite and different constellations of symptoms and signs for I and II. Objective measurements were also different. I induced a dose-related decrease in pupillary diameter and an increase in the signs scratching, relaxed, coasting, talkativeness, and conjunctival injection and caused relaxation, talkativeness, and turning of the stomach. II induced a dose-related increase in the duration of postrotational nystagmus and caused sleepiness and drunkenness. Both drugs induced euphoria.
KW - Pentobarbital--comparison, morphine-;
KW - Morphine--comparison, pentobarbital-;
KW - Analgesics and antipyretics--morphine, comparison, pentobarbital--effects, subjective and objective assessment, in humans;
KW - Sedatives and hypnotics--pentobarbital, comparison, morphine--effects, subjective and objective assessment, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Howard, Cecil G.
T1 - THE RETURNING OVERSEAS EXECUTIVE: CULTURAL SHOCK IN REVERSE.
JO - Human Resource Management
JF - Human Resource Management
Y1 - 1974///Summer74
VL - 13
IS - 2
M3 - Article
SP - 22
EP - 26
SN - 00904848
AB - The article deals with two aspects of the executive's return — one with the problems usually faced by the returning executive, the family and also the company and the other, the measures that can be taken by multinational firms to make the return of the overseas executive and the family a little smoother. It is an accepted fact that when an American goes abroad he or she experiences a cultural shock. However, when they return to their own country they may well experience another cultural shock of sorts, and what is done to prevent and also to overcome this situation is extremely important. Many multinational firms in the U.S. have some kind of formal cultural sensitivity training or orientation program in which the prospective overseas executive and his or her family are thoroughly exposed to the legal, social, religious, political, business, economic, and physical environment of the country to which they are being assigned. Some go to the extent of having language courses and classes conducted by nationals from the country in question or send their executives and their families to commercial language schools for crash language training.
KW - EXECUTIVES
KW - INTERNATIONAL business enterprises
KW - EMPLOYEE orientation
KW - EMPLOYEE training
KW - CULTURE shock
KW - FAMILIES
KW - UNITED States
N1 - Accession Number: 12493285; Howard, Cecil G. 1,2; Affiliations: 1: Researcher, Executive & Management Development Branch, National Institutes of Health, Bethesda, Maryland; 2: School of Business, Georgia Southern College; Issue Info: Summer74, Vol. 13 Issue 2, p22; Thesaurus Term: EXECUTIVES; Thesaurus Term: INTERNATIONAL business enterprises; Thesaurus Term: EMPLOYEE orientation; Thesaurus Term: EMPLOYEE training; Subject Term: CULTURE shock; Subject Term: FAMILIES; Subject: UNITED States; NAICS/Industry Codes: 611430 Professional and Management Development Training; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Milner, John E.
T1 - IN VITRO LYMPHOCYTE RESPONSES IN CONTACT HYPERSENSITIVITY IV.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/06//
VL - 62
IS - 6
M3 - Article
SP - 591
EP - 594
SN - 0022202X
AB - Sixteen patients were sensitized to dinitrofluorobenzene (DNFB) by topical application. Of these, 6 were determined to be 4-sensitized, in that the cutaneous application of 2,000 μg of DNFB resulted in vesiculation, erythema, and edema beyond the border of the test site. Six unsensitized patients were used as controls. The 22 subjects had their lymphocytes cultured in the presence of conjugates of DNFB and human skin (DNP- SP). Responses were quantitated by measuring the incorporation of tritiated thymidine into nucleic acids of the cells in culture. Using a ratio of 3.0 (numbers indicate the ratio of thymidine incorporation in cultures containing DNP SP to those containing univ skin protein [SPJ). 5 of 64- patients were classified as sensitive, and none of the 6 control patients responded to this extent. Of the remainder of the sensitized patients, only 2 of 10 were positive. This indicates that our method, at present, is quite effective in detecting contact sensitivity in strongly positive patients, but insensitive in weakly sensitized patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - ALLERGY
KW - THYMIDINE
KW - NUCLEIC acids
KW - CELL culture
KW - SKIN diseases
N1 - Accession Number: 12679447; Milner, John E. 1; Affiliation: 1: National Cancer Institute Research Career Development Awardee. No. 1 K4 CA 33563-01 IMB; Source Info: Jun74, Vol. 62 Issue 6, p591; Subject Term: LYMPHOCYTES; Subject Term: ALLERGY; Subject Term: THYMIDINE; Subject Term: NUCLEIC acids; Subject Term: CELL culture; Subject Term: SKIN diseases; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12679447
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Eckman, W. W.;
AU - Patalk, C. S.;
AU - Fenstermacher, J. D.;
T1 - Critical evaluation of the principles governing the advantage of intra-arterial infusions
CT - Critical evaluation of the principles governing the advantage of intra-arterial infusions
JO - Journal of Pharmacokinetics and Biopharmaceutics (USA)
JF - Journal of Pharmacokinetics and Biopharmaceutics (USA)
Y1 - 1974/06/01/
VL - 2
IS - Jun
SP - 257
EP - 285
SN - 0090466X
AD - Membrane Transport Section, Experimental Therapeutics Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-4771; Language: English; References: 13; Journal Coden: JPBPBJ; Section Heading: Drug Metabolism and Body Distribution; Pharmacology; Abstract Author: Edwin E. Wiegand
N2 - Mathematical analysis is used to determine the relationship between the time course of drug concentration in the artery to that in the tissue after regional (intra-arterial) or systemic (IV) drug administration. The advantage of an arterial infusion is discussed from the viewpoint that it is dependent on a single probability factor and also that it is independent of the rate of infusion. Two methods are described to experimentally determine any advantage to arterial infusions. The factors that influence the advantage of decreased systemic drug delivery after arterial infusion are evaluated. The relationship between drug delivery and pharmacological activity is studied. Appendices derive the equations used.
KW - Drug administration--routes--intra-arterial, comparison, IV, time course of drug concentration;
KW - Drugs, body distribution--intra-arterial, comparison, intravenous--time course of drug concentration;
KW - Injections--intra-arterial, comparison, intravenous--time course of drug concentration;
KW - Metabolism--blood levels--intra-arterial, comparison, IV, time course of drug concentration;
KW - Blood levels--intra-arterial, comparison, intravenous--time course of drug concentration;
KW - Pharmacokinetics--blood levels--intra-arterial, comparison, IV, time course of drug concentration;
KW - Drugs, availability--intra-arterial, comparison, intravenous--time course of drug concentration;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mantel, Nathan
T1 - Comment and a Suggestion: by, Nathan Mantel.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/06//
VL - 69
IS - 346
M3 - Article
SP - 378
SN - 01621459
AB - The article focuses on comments and suggestions given by the author on topics related to 2 X 2 contingency tables. In commenting on an earlier version of this article, the author suggested that the example given by statistician William J. Conover could be employed to advantage to demonstrate the propriety of using the continuity correction. The reverse demonstration by Conover related not to proper use but rather to misuse of the continuity correction. According to the author, using the continuity correction, he should try to parallel the computations of estimating tail or class-interval probabilities for a normal distribution with known mean and variance. Use of continuity-corrected chi-square for a 2 X 2 table as displayed by Conover is equivalent to considering the cell frequency α to be normally distributed. The excellent agreement between exact individual term probabilities and those based on the use of continuity-corrected chi square, except perhaps at the very extremes is apparent. Thus for one-sided significance testing the use of continuity-corrected chi square should give much the same results as Fisher's exact test. The same should be true for two-sided testing.
KW - CORRELATION (Statistics)
KW - PROBABILITY theory
KW - STATISTICS
KW - GAUSSIAN distribution
KW - DISTRIBUTION (Probability theory)
KW - ESTIMATION theory
KW - VARIANCES
KW - CONTINGENCY tables
KW - CONTINUITY
KW - CHI-squared test
N1 - Accession Number: 4608366; Mantel, Nathan 1; Affiliations: 1: Formerly senior mathematical statistician with the National Cancer Institute, Biostatistios Center, George Washington University, 7979 old Georgetown Rd., Bethesda, Md. 20014.; Issue Info: Jun74, Vol. 69 Issue 346, p378; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ESTIMATION theory; Thesaurus Term: VARIANCES; Subject Term: CONTINGENCY tables; Subject Term: CONTINUITY; Subject Term: CHI-squared test; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Chand, Nanak
T1 - Sequential Tests of Composite Hypothesis.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/06//
VL - 69
IS - 346
M3 - Article
SP - 394
SN - 01621459
AB - A method is given for obtaining sequential tests of composite hypotheses for a certain class of distributions. Approximate properties of the tests are derived and the method illustrated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - STATISTICAL hypothesis testing
KW - PROBABILITY theory
KW - TESTING
KW - APPROXIMATION theory
KW - HYPOTHESIS
KW - SEQUENTIAL analysis
KW - CHARACTERISTIC functions
N1 - Accession Number: 4608434; Chand, Nanak 1; Affiliations: 1: NIH visiting fellow, Environmental Biometry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709.; Issue Info: Jun74, Vol. 69 Issue 346, p394; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: PROBABILITY theory; Thesaurus Term: TESTING; Thesaurus Term: APPROXIMATION theory; Subject Term: HYPOTHESIS; Subject Term: SEQUENTIAL analysis; Subject Term: CHARACTERISTIC functions; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Bast, R. C., Jr.;
AU - Zbar, B.;
AU - Borsos, T.;
AU - Rapp, H. J.;
T1 - BCG and cancer. Parts I and II
CT - BCG and cancer. Parts I and II
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/06/01/
VL - 290
IS - Jun 20; Jun 27
SP - 1413
EP - 1469
SN - 00284793
AD - Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 11-4132; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents BCG vaccines; References: 261; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - The use of BCG in the prevention of tumor growth and treatment of established tumors in animals and humans is reviewed. The combination of BCG immunotherapy with other modes of treatment and the effect of BCG on carcinogenesis are also discussed. Topics reviewed include prevention of acute leukemia by neonatal vaccination with BCG, BCG immunotherapy of human cancer, complications of BCG immunotherapy and possible mechanisms of BCG-mediated tumor suppression and regression.
KW - BCG vaccines--cancer-;
KW - Antineoplastic agents--BCG vaccines--cancer, therapy, review, in animals and humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ROMERO, JORGE A.
AU - AXELROD, JULIUS
T1 - Pineal β-Adrenergic Receptor: Diurnal Variation in Sensitivity.
JO - Science
JF - Science
Y1 - 1974/06/07/
VL - 184
IS - 4141
M3 - Article
SP - 1091
EP - 1092
SN - 00368075
AB - The responsiveness of the pineal β-adrenergic receptor that regulates serotonin-N-acetyltransferase activity is nearly ten times greater at the end of the light period (0600 to 1800 hours) than at the end of the dark period (1800 to 0600 hours). These changes in sensitivity of the postsynaptic β-adrenergic receptor are related to diurnal changes in the release of noradrenaline from sympathetic nerves innervating the pineal. Supersensitivity of the receptor appears to result from decreased release of the neurotransmitter during daytime, and subsensitivity from increased release at night. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85178976; ROMERO, JORGE A. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/ 7/1974, Vol. 184 Issue 4141, p1091; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOWERY, THOMAS G.
AU - FREDERICK, LAFAYETTE
AU - JOHNSON, JOE
T1 - Biomedical Research: Support for Minorities.
JO - Science
JF - Science
Y1 - 1974/06/21/
VL - 184
IS - 4143
M3 - Article
SP - 1230
EP - 1230
SN - 00368075
N1 - Accession Number: 85117664; BOWERY, THOMAS G. 1; FREDERICK, LAFAYETTE 2; JOHNSON, JOE 3; Affiliations: 1: Division of Research Resources, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Biology, Atlanta University, Atlanta, Georgia 30314; 3: Department of Chemistry, Atlanta University; Issue Info: 6/21/1974, Vol. 184 Issue 4143, p1230; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - OKISAKA, SHIGEKUNI
AU - KUWABARA, TOICHIRO
AU - RAPOPORT, STANLEY I.
T1 - Selective Destruction of the Pigmented Epithelium in the Ciliary Body of the Eye.
JO - Science
JF - Science
Y1 - 1974/06/21/
VL - 184
IS - 4143
M3 - Article
SP - 1298
EP - 1299
SN - 00368075
AB - Perfusion of the internal carotid artery with hypertonic solution selectively destroys most of the pigmented epithelium of the ciliary body of the monkey eye, converts fenestrated endothelium of capillaries to continuous endothelium, and transiently breaks down the blood-aqueous barrier. The nonpigmented epithelium regenerates and the intraocular pressure returns to normal even though the pigmented epithelium is permanently destroyed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117697; OKISAKA, SHIGEKUNI 1; KUWABARA, TOICHIRO 1; RAPOPORT, STANLEY I. 2; Affiliations: 1: Laboratory of Vision Reseatrch, National Eye Institute, Bethesda, Maryland 20014; 2: Laboratory of Neurophysiology, Nationial Inistitlute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/21/1974, Vol. 184 Issue 4143, p1298; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Axelrod, Julius
T1 - The Pineal Gland: A Neurochemical Transducer.
JO - Science
JF - Science
Y1 - 1974/06/28/
VL - 184
IS - 4144
M3 - Article
SP - 1341
EP - 1348
SN - 00368075
N1 - Accession Number: 85117711; Axelrod, Julius 1; Affiliations: 1: Chief, pharmacology section, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/28/1974, Vol. 184 Issue 4144, p1341; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - GAINER, HAROLD
T1 - Peptide Regulation of Bursting Pacemaker Activity in a Molluscan Neurosecretory Cell.
JO - Science
JF - Science
Y1 - 1974/06/28/
VL - 184
IS - 4144
M3 - Article
SP - 1371
EP - 1373
SN - 00368075
AB - Vasopressin and related peptides (10-9 to 10-6 molar) induced bursting pacemaker potential activity and altered the current-voltage relations of the membrane in a specific molluscan neurosecretory cell. These effects long outlasted the period of application of the peptides. Sensitivity of the cell to these peptides was primarily localized on the axon hillock region. The observed effects do not resemble conductance changes evoked by conventional neurotransmitters, but rather suggest a membrane regulatory role for these peptides, and thus may be indicative of a new form of information transfer in the nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117731; BARKER, JEFFERY L. 1; GAINER, HAROLD 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/28/1974, Vol. 184 Issue 4144, p1371; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Miller, L. H.;
AU - Glew, R. H.;
AU - Wyler, D. J.;
AU - Howard, W. A.;
AU - Collins, W. E.;
AU - \ET/;
T1 - Evaluation of clindamycin in combination with quinine against multidrug-resistant strains of Plasmodium falciparum
CT - Evaluation of clindamycin in combination with quinine against multidrug-resistant strains of Plasmodium falciparum
JO - Am. J. Trop. Med. Hyg.
JF - Am. J. Trop. Med. Hyg.
Y1 - 1974/07/01/
VL - 23
IS - Jul
SP - 565
EP - 569
AD - Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-3969; Language: English; Chemical Name: Clindamycin--18323-44-9 Quinine--130-95-0; Therapeutic Class: (8:20); AHFS Class: Plasmodicides quinine and clindamycin; References: 15; Journal Coden: AJTHAB; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The efficacy of clindamycin in combination with quinine was determined against 3 multidrug-resistant strains of Plasmodium falciparum. No recrudescences occurred after treatment with quinine 650 mg orally every 8 hours for 3 days and clindamycin 450 mg orally every 6 hours for 3 days, when administered either simultaneously or sequentially. Quinine alone for 3 days was not curative against infections with these strains. During a 3-day course of therapy, blood levels of quinine or clindamycin were not influenced by administration of the other drug.
KW - Clindamycin--and quinine-;
KW - Quinine--and clindamycin-;
KW - Combined therapy--clindamycin and quinine--Plasmodium falciparum, therapy, in patients;
KW - Combined therapy--quinine and clindamycin--Plasmodium falciparum therapy, in patients;
KW - Plasmodicides--quinine and clindamycin--Plasmodium falciparum, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kaplan, J.;
AU - Dawson, S.;
AU - Vaughan, T.;
AU - Green, R.;
AU - Wyatt, R. J.;
T1 - Effect of prolonged chlorpromazine administration on the sleep of chronic schizophrenics
CT - Effect of prolonged chlorpromazine administration on the sleep of chronic schizophrenics
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/07/01/
VL - 31
IS - Jul
SP - 62
EP - 66
AD - Laboratory of Clinical Psychopharmacology, IRP National Institute of Mental Health, Saint Elizabeth's Hospital, WAW Bldg, Washington, D.C. 20032
N1 - Accession Number: 12-5306; Language: English; Trade Name: Thorazine; Generic Name: Chlorpromazine; Chemical Name: Chlorpromazine--50-53-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlorpromazine; References: 44; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - EEG recordings were performed on the sleep of 13 chronic male schizophrenics after 3 weeks on chlorpromazine HCl (thorazine) or placebo. Chlorpromazine reduced sleep latency and awake time but increased stage II, delta sleep, delta%, non-rapid eye movement sleep and rapid eye movement activity, latency and density.
KW - Chlorpromazine--effects-;
KW - Tranquilizers--chlorpromazine--effects, sleep, in schizophrenic patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fauci, A. S.;
AU - Dale, D. C.;
AU - Wolff, S. M.;
T1 - Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis
CT - Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis
JO - Arthritis and Rheumatism (USA)
JF - Arthritis and Rheumatism (USA)
Y1 - 1974/07/01/
VL - 17
IS - Jul-Aug
SP - 355
EP - 361
SN - 00043591
AD - Building 10, Room 11 B09 National Institutes of Health Bethesda, Maryland 20014
N1 - Accession Number: 12-2055; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 28; Journal Coden: ARHEAW; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Pongsri Sangkachand
N2 - The specific effects of cyclophosphamide on circulating lymphocytes were compared in 3 males and 3 females aged 36-66 years receiving 25-50 mg. cyclophosphamide daily, 3 males and 3 females aged 27-66 years whose cyclophosphamide had been discontinued 2-26 months previously, and a group of normal controls. Among patients receiving cyclophosphamide, therapy ranged from 1-57 months, and, among those whose therapy was discontinued, the duration had been 1.5-57 months. The latter were divided into 2 groups: (1) 4 patients from whom the drug had been withdrawn less than 4 months previously, and (2) 2 other patients who had not taken the drug for 12-26 months. In 10 patients with Wegener's granulomatosis, low doses produced severe lymphocytopenia of long duration even after therapy ceased; a greater percentage decreased in nonrosette forming lymphocytes than in rosette forming T-lymphocytes; normal in vitro lymphocyte responses to mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) with suppressed responses to 1 of 2 antigens tested (streptokinase-streptodornase). This regimen did not cause severe granulocytopenia and was successful in inducing and maintaining long-term clinical remissions.
KW - Cyclophosphamide--toxicity-;
KW - Antineoplastic agents--cyclophosphamide--lymphocytopenia, in Wegener's granulomatosis, in patients;
KW - Lymphocytes--cyclophosphamide--depletion, in Wegener's granulomatosis, in patients;
KW - Toxicity--cyclophosphamide--studies, lymphocytopenia, in Wegener's granulomatosis, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Haworth, Mary R.
T1 - RELATIONSHIPS BETWEEN THE PRIMARY VISUAL MOTOR TEST, S-B VOCABULARY SUBTEST AND MENTAL AGE.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1974/07//
VL - 30
IS - 3
M3 - Article
SP - 326
EP - 330
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article analyzes the relationships among Primary Visual Motor Test (PVM) scores, Vocabulary subtest scores and mental ages on the Stanford-Binet, Form L-M, for children 5 through 8 years of age, using data from the PVM normative sample. Correlation of PVM with Vocabulary was significant, but of a lower magnitude. When mental age was partialled out correlation between tests was negligible, an indication that the PVM and Vocabulary are tapping different aspects of general intellectual functioning, presumably performance and verbal dimensions.
KW - STANFORD-Binet Test
KW - MENTAL age
KW - INTELLIGENCE levels
KW - AGE & intelligence
KW - PSYCHOLOGICAL tests for children
KW - CLINICAL psychology
N1 - Accession Number: 15844702; Haworth, Mary R. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jul1974, Vol. 30 Issue 3, p326; Subject Term: STANFORD-Binet Test; Subject Term: MENTAL age; Subject Term: INTELLIGENCE levels; Subject Term: AGE & intelligence; Subject Term: PSYCHOLOGICAL tests for children; Subject Term: CLINICAL psychology; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Weiss, H. D.;
AU - Walker, M. D.;
AU - Wiernik, P. H.;
T1 - Neurotoxicity of commonly used antineoplastic agents. Parts I and II
CT - Neurotoxicity of commonly used antineoplastic agents. Parts I and II
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/07/01/
VL - 291
IS - Jul 11; Jul 18
SP - 75
EP - 33
SN - 00284793
AD - Reprints: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114
AD - Sections of Neurological Surgery and Medicine, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland
N1 - Accession Number: 11-4094; Language: English; References: 157; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - The neurotoxicities of asparaginase, fluorouracil, methotrexate, nitrogen mustard (mechlorethamine), procarbazine, vincristine and vinblastine in humans are reviewed.
KW - Toxicity--antineoplastic agents--neuro-, review, in humans;
KW - Antineoplastic agents--toxicity--neuro-, review, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - FARACI, ROBERT P.
AU - SCHOUR, LIONEL
T1 - Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice.
JO - Science
JF - Science
Y1 - 1974/07/05/
VL - 185
IS - 4145
M3 - Article
SP - 68
EP - 69
SN - 00368075
AB - Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117770; FARACI, ROBERT P. 1; SCHOUR, LIONEL 1; Affiliations: 1: Surgery Branch, National Cancer Institute, National Instituttes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 5/1974, Vol. 185 Issue 4145, p68; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FUKUDA, JUN
T1 - Chloride Spike: A Third Type of Action Potential in Tissue-Cultured Skeletal Muscle Cells from the Chick.
JO - Science
JF - Science
Y1 - 1974/07/05/
VL - 185
IS - 4145
M3 - Article
SP - 76
EP - 78
SN - 00368075
AB - In addition to sodium and calcium spikes, tissue-cultured skeletal muscle cells from the chick can initiate spikes lasting tens of seconds. The peak membrane potential of the spike correlates with the chloride ion concentration, but not with the calcium or sodium ion concentration. The chloride spike is blocked by manganese ion but not by cobalt ion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117774; FUKUDA, JUN 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/ 5/1974, Vol. 185 Issue 4145, p76; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Klippel, J. H.;
AU - Decker, J. L.;
T1 - Relative macrocytosis in cyclophosphamide and azathioprine therapy
CT - Relative macrocytosis in cyclophosphamide and azathioprine therapy
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1974/07/08/
VL - 229
IS - Jul 8
SP - 180
EP - 181
AD - Building 10, Room 9N218, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-4078; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Azathioprine--446-86-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents azathioprine; References: 6; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2 - A relative increase in erythrocyte volume was observed in patients with connective tissue disease who were treated with cyclophosphamide and azathioprine.
KW - Cyclophosphamide--adverse reactions-;
KW - Azathioprine--adverse reactions-;
KW - Drugs, adverse reactions--cyclophosphamide--macrocytosis, in patients with connective tissue disease;
KW - Antineoplastic agents--cyclophosphamide--macrocytosis, in patients with connective tissue disease;
KW - Drugs, adverse reactions--azathioprine--macrocytosis, in patients with connective tissue disease;
KW - Antineoplastic agents--azathioprine--macrocytosis, in patients with connective tissue disease;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brereton, H. D.;
AU - Halushka, P. V.;
AU - Alexander, R. W.;
AU - Mason, D. M.;
AU - Keiser, H. R.;
AU - \ET/;
T1 - Indomethacin responsive hypercalcemia in a patient with renal cell adenocarcinoma
CT - Indomethacin responsive hypercalcemia in a patient with renal cell adenocarcinoma
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/07/11/
VL - 291
IS - Jul 11
SP - 83
EP - 85
SN - 00284793
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 11-4129; Language: English; Chemical Name: Indomethacin--53-86-1; References: 10; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - A case report is presented of a 54-year-old male in whom hypercalcemia secondary to neoplastic disease was responsive to indomethacin therapy (25 mg. orally twice a day).
KW - Indomethacin--hypercalcemia-;
KW - Hypercalcemia--indomethacin--therapy, secondary to neoplastic disease, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BROWNSTEIN, MICHAEL J.
AU - PALKOVITS, MIKLOS
AU - SAAVEDRA, JUAN M.
AU - BASSIRI, RABIM M.
AU - UTIGER, ROBERT D.
T1 - Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain.
JO - Science
JF - Science
Y1 - 1974/07/19/
VL - 185
IS - 4147
M3 - Article
SP - 267
EP - 269
SN - 00368075
AB - The regional distribution of thyrotropin-releasing hormzone (TRH) in rat brain was studied. The greatest concentration of TRH was found in the mnedian eminence. High concentrations were also found in several hypothalamic nuclei. Outside the hypothalamus, relatively large amounts of TRH were found in the septal and preoptic areas. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117839; BROWNSTEIN, MICHAEL J. 1; PALKOVITS, MIKLOS 1; SAAVEDRA, JUAN M. 1; BASSIRI, RABIM M. 2; UTIGER, ROBERT D. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Endocrine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104; Issue Info: 7/19/1974, Vol. 185 Issue 4147, p267; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GLOSSMANNE, H.
AU - BAUKAL, A.
AU - CATT, K. J.
T1 - Cation Dependence of High-Affinity Angiotensin II Binding to Adrenal Cortex Receptors.
JO - Science
JF - Science
Y1 - 1974/07/19/
VL - 185
IS - 4147
M3 - Article
SP - 281
EP - 283
SN - 00368075
AB - The specific binding of monoiodinated angiotensin 11 by particulate receptors from the bovine adrenal cortex is enhanced by addition of sodium and potassium ions, but not other cations. In the presence of 140 millimolar sodium, increased uptake of angiotensin II by adrenal receptors is associated with the appearance of high-affinity binding sites with an association constant of 2 X 109 liters per mole. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117846; GLOSSMANNE, H. 1; BAUKAL, A. 1; CATT, K. J. 1; Affiliations: 1: Section on Hormonal Regulation, Reproduction Research Branch, National Inistituite of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/19/1974, Vol. 185 Issue 4147, p281; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAM JR., WILLIAM T.
AU - MUELLER, HAROLD A.
AU - GOLDMAN, ARNOLD I.
AU - NEWNAM, BRIAN E.
AU - HOLLAND, L. M.
AU - KUWABARA, T.
T1 - Ocular Hazard from Picosecond Pulses of Nd: YAG Laser Radiation.
JO - Science
JF - Science
Y1 - 1974/07/26/
VL - 185
IS - 4148
M3 - Article
SP - 362
EP - 363
SN - 00368075
AB - Seven rhesus monkeys (14 eyes) wer-e exposed to 1064-nanometer radiation in single pulses of 25 to 35 picoseconds fromn a nmode-locked Nd: YA G laser. Threshold injury resulted fromi single pulses with a mnean energy of 13 ± 3 mnicrojoules. Electron microscopy of the retina revealed that damnage was highly localized in the photoreceptor and pigmented epithelial cells at the oluter retina. Menbrane disrluption, distorted outer segmtzents, and abnormnal mnelanin granules resembling fetal premelanosomnies were observed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345698; HAM JR., WILLIAM T. 1; MUELLER, HAROLD A. 1; GOLDMAN, ARNOLD I. 1; NEWNAM, BRIAN E. 2; HOLLAND, L. M. 2; KUWABARA, T. 3; Affiliations: 1: Department of Biophysics, Virginia Commonwealth University, Richmond; 2: L Division and H Division, Los Alamos Scientific Laboratory, Los Alamos, New Mexico 87544; 3: Natioinal Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/26/1974, Vol. 185 Issue 4148, p362; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SAAVEDRA, JUAN M.
AU - BROWNSTEIN, MICHAEL J.
AU - CARPENTER, DAVID O.
AU - AXELROD, JULIus
T1 - Octopamine: Presence in Single Neurons of Aplysia Suggests Neurotransmitter Function.
JO - Science
JF - Science
Y1 - 1974/07/26/
VL - 185
IS - 4148
M3 - Article
SP - 364
EP - 365
SN - 00368075
AB - Octopamine has been identified and measured in individual neurons from Aplysia californica. Neither dopamine nor norepinephrine was detected in these cells. Thus, in Aplysia there may be separate populations of catecholaminergic and monophenolaminergic cells. Octopamine may have functions of its own in the central nervous system of mollusks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345699; SAAVEDRA, JUAN M. 1; BROWNSTEIN, MICHAEL J. 1; CARPENTER, DAVID O. 2; AXELROD, JULIus 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Neutrobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; Issue Info: 7/26/1974, Vol. 185 Issue 4148, p364; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dixon, R. L.;
T1 - Toxicology of environmental agents: blend of applied and basic research
CT - Toxicology of environmental agents: blend of applied and basic research
JO - American Journal of Pharmaceutical Education (USA)
JF - American Journal of Pharmaceutical Education (USA)
Y1 - 1974/08/01/
VL - 38
IS - Aug
SP - 348
EP - 353
SN - 00029459
AD - Environmental Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
N1 - Accession Number: 13-3008; Language: English; References: 2; Journal Coden: AJPDAD; Section Heading: Pharmaceutical Education; Abstract Author: Drucella Andersen
N2 - The goal of toxicology training programs, through a strengthening of the scientific predictive base for environmental toxicology both in approach and in methodology to ensure the use of experimental animal studies, is discussed.
KW - Toxicology--education--environmental;
KW - Education--toxicology--environmental;
KW - Toxicity, environmental--education--programs, toxicology, goals;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3008&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chu, K. C.;
T1 - Applications of artificial intelligence to chemistry: use of pattern recognition and cluster analysis to determine the pharmacological activity of some organic compounds
CT - Applications of artificial intelligence to chemistry: use of pattern recognition and cluster analysis to determine the pharmacological activity of some organic compounds
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1974/08/01/
VL - 46
IS - Aug
SP - 1181
EP - 1187
AD - Computer Systems Laboratory, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 11-4731; Language: English; References: 20; Journal Coden: ANCHAM; Section Heading: Methodology; Pharmacology
N2 - A wide variety of pattern recognition and cluster analysis techniques can correlate and classify a set of highly diversified organic molecules into their sedative and tranquilizer activity using augmented atom fragments to represent the chemical structures.
KW - Automation, data processing, computers--pharmacology--use of pattern recognition and cluster analysis to determine activity;
KW - Research--pharmacology--use of pattern recognition and cluster analysis to determine activity;
KW - Cluster analysis--pharmacology--research, to determine activity of organic compounds;
KW - Pattern recognition--pharmacology--research, to determine activity of organic compounds;
KW - Structure-activity relationships--cluster analysis--and pattern recognition, to determine pharmacological activity;
KW - Tranquilizers--pharmacology--use of pattern recognition and cluster analysis to identify activity;
KW - Sedatives and hypnotics--pharmacology--use of pattern recognition and cluster analysis to identify activity;
KW - Methodology--sedatives and hypnotics--cluster analysis and pattern recognition to identify activity;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Katz, M. M.;
AU - Itil, T. M.;
T1 - Video methodology for research in psychopathology and psychopharmacology
CT - Video methodology for research in psychopathology and psychopharmacology
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/08/01/
VL - 31
IS - Aug
SP - 204
EP - 210
AD - Clinical Research Branch, National Institute of Mental Health, Dept. of H.E.W., 5600 Fishers La., Rockville, Maryland 20852
N1 - Accession Number: 12-5692; Language: English; Trade Name: Mellaril--Navane; Generic Name: Thioridazine; Thiothixene; Chemical Name: Thioridazine--50-52-2 Thiothixene--5591-45-7; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers thioridazine, comparison, thiothixene (28:16.08); AHFS Class: Tranquilizers thiothixene, comparison, thioridazine; References: 20; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Methodology; Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - The application and value of video methods in evaluating thioridazine (Mellaril) and thiothixene (Navane) showed advantages over a study that utilized conventionally designed methods. The results of analysis from video interview method showed that thioridazine appeared to be more effective in reducing anxiety and depression, whereas thiothixene therapy decreased apathy in geriatric patients with chronic brain syndrome. The method demonstrated increased sensitivity in detecting systemic and important differences in behavioral effects between the drugs. Video recording contributes to the descriptive and measurement phase of research. It improves reliability of ratings, establishes comparability of samples across settings, increases sensitivity and validity, balances, out the background characteristics of clinicians, and controls the time-related bias of raters in treatment studies.
KW - Thioridazine--comparison, thiothixene-;
KW - Thiothixene--comparison, thioridazine-;
KW - Tranquilizers--thioridazine, comparison, thiothixene--effects, use of video interview methodology in evaluation;
KW - Tranquilizers--thiothixene, comparison, thioridazine--effects, use of video interview methodology in evaluation;
KW - Methodology--interviews--video, use in evaluation of thioridazine and thiothixene, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Soter, Nicholas A.
AU - Austen, K. Frank
AU - Gigli, Irma
T1 - THE COMPLEMENT SYSTEM IN NECROTIZING ANGIITIS OF THE SKIN. ANALYSIS OF COMPLEMENT COMPONENT ACTIVITIES IN SERUM OF PATIENTS WITH CONCOMITANT COLLAGEN-VASCULAR DISEASES.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/08//
VL - 63
IS - 2
M3 - Article
SP - 219
EP - 226
SN - 0022202X
AB - Profiles of serum complement components were studied in patients with necrotizing angiitis (vasculitis) of the skin and concomitant rheumatoid arthritis, Sjögren's syndrome, or systemic lupus erythematosus. In patients with either rheumatoid arthritis or Sjögren's syndrome, the early components--C1, C4, and C2--were depressed. When cryoglobulins containing mainly IgG and IgM were present in the patients with Sjögren's syndrome, there was further preferential reduction of C4 and C2 in serum and functionally active C1 molecules were present in the cryoprotein. A patient with Sjögren's syndrome and a cryoprotein containing large amounts of IgA exhibited depression of C3 levels with sparing of the early components, presumably reflecting activation of an alternate pathway of C3 consumption. Patients with systemic lupus erythematosus and vasculitis presented abnormalities of both early and late components of the complement system with a stricking depression of Clq levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VASCULITIS
KW - SKIN
KW - SERUM
KW - COLLAGEN
KW - VASCULAR diseases
KW - RHEUMATOID arthritis
KW - SJOGREN'S syndrome
N1 - Accession Number: 12679439; Soter, Nicholas A. 1 Austen, K. Frank 1 Gigli, Irma 2; Affiliation: 1: Carl Herzug Fellow, American Dermatological Association 2: Recipient of Research Career Development Award AM-46409, National Institutes of Health; Source Info: Aug74, Vol. 63 Issue 2, p219; Subject Term: VASCULITIS; Subject Term: SKIN; Subject Term: SERUM; Subject Term: COLLAGEN; Subject Term: VASCULAR diseases; Subject Term: RHEUMATOID arthritis; Subject Term: SJOGREN'S syndrome; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12679439
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Otani, T. T.;
AU - Briley, M. R.;
T1 - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine: preparation and separation of diastereomers
CT - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine: preparation and separation of diastereomers
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/08/01/
VL - 63
IS - Aug
SP - 1253
EP - 1256
SN - 00223549
AD - Nucleic Acids Section, Laboratory of Biochemistry, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-6224; Language: English; References: 8; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - \b/-Hydroxyhomomethionine and \b/-hydroxymethoxinine were prepared by one-step condensation of the corresponding aldehydes with cupric glycinate in an alkaline medium; the diastereomers of each compound were separated by means of partitioned column chromatography.
KW - \b/-Hydroxyhomomethionine--synthesis-;
KW - \b/-Hydroxymethoxinine--synthesis-;
KW - Chromatography, column--\b/-hydroxyhomomethionine--separation, diastereomers;
KW - Chromatography, column--\b/-hydroxymethoxinine--separation, diastereomers;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Jerina, D. M.
AU - Daly, J. W.
T1 - Arene Oxides: A New Aspect of Drug Metabolism.
JO - Science
JF - Science
Y1 - 1974/08/16/
VL - 185
IS - 4151
M3 - Article
SP - 573
EP - 582
SN - 00368075
N1 - Accession Number: 85178987; Jerina, D. M. 1; Daly, J. W. 2; Affiliations: 1: Chief, Section on Oxidation Mechanisms National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief of Section on Pharmacodynamics, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p573; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jacobs, Barbara B.
AU - Uphoff, Delta E.
T1 - Immunologic Modification: A Basic Survival Mechanism.
JO - Science
JF - Science
Y1 - 1974/08/16/
VL - 185
IS - 4151
M3 - Article
SP - 582
EP - 587
SN - 00368075
N1 - Accession Number: 85178988; Jacobs, Barbara B. 1; Uphoff, Delta E. 2; Affiliations: 1: Director of immunology of American Medical Center, Denver, Spivak, Colorado 80214 National Cancer Institute, Bethesda, Maryland 20014; 2: Senior investigator, Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p582; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GORMAN, A. L. F.
AU - MCREYNOILDS, JOHN S.
T1 - Control of Membrane K+ Permeability in a Hyperpolarizing Photoreceptor: Similar Effects of Light and Metabolic Inhibitors.
JO - Science
JF - Science
Y1 - 1974/08/16/
VL - 185
IS - 4151
M3 - Article
SP - 620
EP - 621
SN - 00368075
AB - In the hyperpolarizing photoreceptors of the scallop Pecten irradians the metabolic inhibitors cyani 'e and 2,4-dinitrophenol cause a rapid hyperpolarization and increase in membrane permeability to potassium ions, similar to the effect of light. Cellular metabolism appears important in maintaining the low permeability to potassium ions necessary to keep the membrane depolarized in darkness, possibly by regulating the intracellular calcium ion concentration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85179010; GORMAN, A. L. F. 1; MCREYNOILDS, JOHN S. 2; Affiliations: 1: Department of Physiology, Boston University School of Medicine, Boston, Massachusetts 02118; 2: Laboratory of Nelurophysiology. National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p620; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BLOOM, F. E.
AU - SIGGINS, G. R.
AU - HOFFER, B. J.
T1 - Interpreting the Failures to Confirm the Depression of Cerebellar Purkinje Cells by Cyclic AMP.
JO - Science
JF - Science
Y1 - 1974/08/16/
VL - 185
IS - 4151
M3 - Article
SP - 627
EP - 629
SN - 00368075
N1 - Accession Number: 85179014; BLOOM, F. E. 1; SIGGINS, G. R. 1; HOFFER, B. J. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/16/1974, Vol. 185 Issue 4151, p627; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Coller, B. S.;
AU - Lundberg, W. B.;
AU - Albright, L.;
AU - Ommaya, A. K.;
AU - Gralnick, H. R.;
T1 - Positive antiglobulin test after BCG immunotherapy
CT - Positive antiglobulin test after BCG immunotherapy
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/08/29/
VL - 291
IS - Aug 29
SP - 474
SN - 00284793
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-0633; Language: English; Trade Name: CCNU; Generic Name: Lomustine; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - In an 8-year-old boy with left-parietal astrocytoma, a persistently positive direct (and later indirect) antiglobulin test developed after 8 months of the following antitumor therapy: biweekly S.C. injections of neuramidinase treated autologous tumor cells; monthly intradermal BCG and intratumoral purified protein derivative of tuberculin (via a reservoir); systemic lomustine (CCNU); and intratumoral 8-azaguanine.
KW - BCG vaccines--combined therapy-;
KW - Combined therapy--BCG vaccines--effects, positive antiglobulin test, in child;
KW - Immunosuppressive agents--BCG vaccines--combined therapy, effects, positive antiglobulin test, in child;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - SLOTNICK, BURTON M.
AU - KATZ, HOWARD M.
T1 - Olfactory Learning-Set Formation in Rats.
JO - Science
JF - Science
Y1 - 1974/08/30/
VL - 185
IS - 4153
M3 - Article
SP - 796
EP - 798
SN - 00368075
AB - Rats trained on 16 two-odor discrimination problems showed rapid acquisition of a learning set and one-trial learning by the end of the problem series. Learning to sample odor cues before responding and adoption of a "winstay, lose-shift" strategy probably accounts for the virtually errorless learning. Learning-set performance of rats trained with odor stimuli is comparable to that reported for primates trained on visual cues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158905; SLOTNICK, BURTON M. 1; KATZ, HOWARD M. 2; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Tuifts University School of Medicine, Boston, Massachusetts 02111; Issue Info: 8/30/1974, Vol. 185 Issue 4153, p796; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Levine, D. G.;
AU - Preston, P. A.;
AU - Lipscomb, S. G.;
AU - Ross, W. F.;
T1 - Special program for nurse addicts
CT - Special program for nurse addicts
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 1974/09/01/
VL - 74
IS - Sep
SP - 1672
EP - 1673
SN - 0002936X
AD - Clinical Research Center, National Institute of Mental Health, Lexington, Kentucky
N1 - Accession Number: 14-0613; Language: English; References: 5; Journal Coden: AJNUAK; Section Heading: Sociology, Economics and Ethics; Abstract Author: Jimmie L. Hall
N2 - A treatment and research unit designed for nurses who used drugs illicitly is described.
KW - Dependence--nurses--therapy, program design;
KW - Nurses--dependence--therapy, program design;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levine, D. G.;
AU - Lipscomb, S. G.;
AU - Preston, P. A.;
T1 - Historical approach to understanding drug abuse among nurses
CT - Historical approach to understanding drug abuse among nurses
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1974/09/01/
VL - 131
IS - Sep
SP - 1036
EP - 1037
SN - 0002953X
AD - Reprints: San Francisco Methadone Treatment Program, 3626 Geary Blvd., San Francisco, California 94118
AD - National Institute of Mental Health Research Center, Lexington, Kentucky
N1 - Accession Number: 12-2885; Language: English; References: 8; Journal Coden: AJPSAO; Section Heading: Sociology, Economics and Ethics; Abstract Author: C. Robert Sturwold
N2 - The findings of a study of 12 registered nurses who used drugs illicitly are presented. Historical antecedents of drug abuse were investigated through interviews of the nurse addict to explore personal and family history, health, finances, sexual activities, and history of drug abuse. A medical dependence became evident, manifested by early and extensive involvement in medical treatment, somatic orientation, chronic medical difficulties, dependence on alcohol, and, finally, dependence on other drugs. Irrational attitudes toward addicting substances viewed by the subjects are also considered contributory to their addiction.
KW - Drug abuse--nurses--personal histories of 12 addicted nurses;
KW - Nurses--drug abuse--personal histories of 12 addicted nurses;
KW - Dependence--drugs--nurses, personal histories;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Benson Jr., J.W.
AU - Buja, M. L.
AU - Thompson, R. H.
AU - Gordon Jr., R. S.
T1 - GLUCOSE UTILIZATION BY SWEAT GLANDS DURING FASTING IN MAN.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/09//
VL - 63
IS - 3
M3 - Article
SP - 287
EP - 291
SN - 0022202X
AB - Fifteen normal subjects were fasted for 3-7 days while undergoing daily sweating in an environmental chamber. Sweat lactate concentration decreased 19% and reached a new steady state by the third day of last. Recovery of 13C-labeled lactate in sweat after injection of 14C-labeled glucose was enhanced ruing starvation, suggesting preferential utilization of circulating glucose for sweat gland glycogen content decreased markedly during sweating in fasted subjects nearly complete recovery of normal glycogen content was observed 6 hr after conclusion of sweating. In the sweat gland, significant dependence upon carbohydrate metabolism persists during the fasted state. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCOSE
KW - SWEAT glands
KW - CUTANEOUS glands
KW - FASTING
KW - LACTATES
KW - CARBOHYDRATE metabolism
N1 - Accession Number: 12680165; Benson Jr., J.W. 1 Buja, M. L. 2 Thompson, R. H. 1 Gordon Jr., R. S. 1; Affiliation: 1: The Section on Physilogy and Clinical Nutrition, Digestive Diseases Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland, 20014. 2: The National heart and Lung Institute National Institutes of Health, Bethesda, Maryland 20014; Source Info: Sep74, Vol. 63 Issue 3, p287; Subject Term: GLUCOSE; Subject Term: SWEAT glands; Subject Term: CUTANEOUS glands; Subject Term: FASTING; Subject Term: LACTATES; Subject Term: CARBOHYDRATE metabolism; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12680165
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kiefer, James E.
AU - Weiss, George H.
T1 - Truncated Version of a Play-the-Winner Rule for Choosing the Better of Two Binomial Populations.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/09//
VL - 69
IS - 347
M3 - Article
SP - 807
SN - 01621459
AB - Results are developed for play-the-winner sampling for choosing the better of two binomial populations when the maximum number of tests is specified. It is shown that for a fixed number of tests the probability of correct selection with alternating assignment exceeds that for play- the-winner sampling. However, when the probability of correct selection is fixed, neither sampling method is uniformly better than the other as measured by the expected number of tests on the poorer population, or on the total expected number of tests. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - MATHEMATICS
KW - MATHEMATICAL analysis
KW - NUMERICAL analysis
KW - BINOMIAL distribution
KW - BINOMIAL theorem
N1 - Accession Number: 4612438; Kiefer, James E. 1; Weiss, George H. 2; Affiliations: 1: Mathematician, Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md. 20014.; 2: Chief, Physical Sciences Laboratory, Division of Computer Research and Technology, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md. 20014.; Issue Info: Sep74, Vol. 69 Issue 347, p807; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICS; Thesaurus Term: MATHEMATICAL analysis; Subject Term: NUMERICAL analysis; Subject Term: BINOMIAL distribution; Subject Term: BINOMIAL theorem; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Little, Betsy Carter
AU - Zahn, Theodore P.
T1 - Changes in Mood and Autonomic Functioning During the Menstrual Cycle.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1974/09//
VL - 11
IS - 5
M3 - Article
SP - 579
EP - 590
SN - 00485772
AB - The autonomic nervous system activity and mood ratings of 12 women were studied 6 days a week for a complete menstrual cycle. The daily procedure consisted of a resting period, a series of 5 mild tones, time estimation (TE), and reaction time (RT) trials, and a final resting period. Significant increase in heart rate (HR), respiration rate, and body temperature, and a significant decrease in resting skin conductance (SC) were found during the luteal phase. During the ovulatory phase there were significant increases in autonomic responsivity, as shown by greater amplitude of SC response in the TE and RT situations as well as in faster SC drop-rate and greater HR variability. All of these autonomic variability measures coincided with a significant peak in feelings of elation and vigor. Significant age effects were that older women had higher basal body temperatures, less marked HR variability, and tended to have lower levels of SC, particularly in the luteal phase of the cycle. The results are discussed in terms of the psychophysiological effects of estrogen and progesterone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENSTRUATION
KW - MOOD (Psychology)
KW - AUTONOMIC nervous system
KW - PSYCHOPHYSIOLOGY
N1 - Accession Number: 11088164; Little, Betsy Carter 1 Zahn, Theodore P. 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health; Source Info: Sep1974, Vol. 11 Issue 5, p579; Subject Term: MENSTRUATION; Subject Term: MOOD (Psychology); Subject Term: AUTONOMIC nervous system; Subject Term: PSYCHOPHYSIOLOGY; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MAYER, ROBERT J.
AU - SMITH, R. GRAHAM
AU - GALLO, ROBERT C.
T1 - Reverse Transcriptase in Normal Rhesus Monkey Placenta.
JO - Science
JF - Science
Y1 - 1974/09/06/
VL - 185
IS - 4154
M3 - Article
SP - 864
EP - 867
SN - 00368075
AB - Particles with the morphology of type C virus have been identified from primate placentas by electron microscopy. A reverse transcriptase (RNAdependent DNA polymerase) was isolated and purified from microsomal pellets of two fresh placentas of rhesus monkeys in the early stages of gestation. This enzyme was biochemically similar yet immunologically distinct from the reverse transcriptases of known tumorigenic type C RNA viruses isolated from primates, but was immunologically related to a reverse transcriptase isolated from a type C virus obtained from normal baboon placenta. These particles may represent endogenous viruses and may ftinction in the transfer of genetic information during embryogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136084; MAYER, ROBERT J.; SMITH, R. GRAHAM 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/ 6/1974, Vol. 185 Issue 4154, p864; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAPIKIAN, ALBERT Z.
AU - KIM, HYUN WHA
AU - WYATT, RICHARD G.
AU - RODRIGUEZ, WILLIAM J.
AU - ROSS, SYDNEY
AU - CLINE, W. LEE
AU - PARROTT, ROBERT H.
AU - CHANOCK, ROBERT M.
T1 - Reoviruslike Agent in Stools: Association with Infantile Diarrhea and Development of Serologic Tests.
JO - Science
JF - Science
Y1 - 1974/09/20/
VL - 185
IS - 4156
M3 - Article
SP - 1049
EP - 1053
SN - 00368075
AB - Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117875; KAPIKIAN, ALBERT Z. 1; KIM, HYUN WHA 2; WYATT, RICHARD G. 3; RODRIGUEZ, WILLIAM J. 4; ROSS, SYDNEY 4; CLINE, W. LEE; PARROTT, ROBERT H. 4; CHANOCK, ROBERT M. 3; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Children's Hospital, Washington, D.C. 20009; 3: National Institute of Allergy and Infectious Diseases; 4: Children's Hospital; Issue Info: 9/20/1974, Vol. 185 Issue 4156, p1049; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VALLE, DAVID L.
AU - PHANG, JAMES M.
AU - GOODMAN, STEPHEN I.
T1 - Type 2 Hyperprolinemia: Absence of Δ¹-Pyrroline-5-Carboxylic Acid Dehydrogenase Activity.
JO - Science
JF - Science
Y1 - 1974/09/20/
VL - 185
IS - 4156
M3 - Article
SP - 1053
EP - 1054
SN - 00368075
AB - Δ¹-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117876; VALLE, DAVID L. 1; PHANG, JAMES M. 1; GOODMAN, STEPHEN I. 2; Affiliations: 1: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Departmtient of Pediatrics, University of Colorado Medical Center, 4200 East Ninth Avenue, Denver 80220; Issue Info: 9/20/1974, Vol. 185 Issue 4156, p1053; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YOSHIKAMI, S.
AU - ROBINSON, W. E.
AU - HAGINS, W. A.
T1 - Topology of the Outer Segment Membranes of Retinal Rods and Cones Revealed by a Fluorescent Probe.
JO - Science
JF - Science
Y1 - 1974/09/27/
VL - 185
IS - 4157
M3 - Article
SP - 1176
EP - 1179
SN - 00368075
AB - When N,N'-didansyl cystine binds to the cell membranes of vertebrate rods and cones its fluorescence efficiency increases about 20-fold. The entire outer segments of living cones become brilliantly fluorescent. Stained live rods, as well as most freshly detached outer segments, are only weakly fluorescent, but they become brightly fluorescent within a few seconds if their plasma membranes are osmotically ruptured. The difference in staining of rod and cones suggests that disk membranes of rods are not continuous with the plasma membranes are osmotically ruptured. The difference in staining of rod and cones plasma membrane on outer segments of photoreceptors in electrophysiological and biochemical experiments, and to study the infolding pattern of rod and cone disks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117920; YOSHIKAMI, S. 1; ROBINSON, W. E. 1; HAGINS, W. A. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/27/1974, Vol. 185 Issue 4157, p1176; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Mitchell, J. R.;
AU - Thorgeirsson, S. S.;
AU - Potter, W. Z.;
AU - Jollow, D. J.;
AU - Keiser, H.;
T1 - Acetaminophen-induced hepatic injury: protective role of gluthathione in man and rationale for therapy
CT - Acetaminophen-induced hepatic injury: protective role of gluthathione in man and rationale for therapy
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1974/10/01/
VL - 16
IS - Oct
SP - 676
EP - 684
SN - 00099236
AD - Lab. of Chemical Pharmacology and Hypertension-Endocrine Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 12-5243; Language: English; Chemical Name: Acetaminophen--103-90-2 Glutathione--70-18-8; References: 27; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Recent studies of acetaminophen induced liver damage in animals indicate that acetaminophen is converted in the liver to a chemically reactive arylating agent that normally is detoxified by conjugation with glutathione. When the dose of acetaminophen is large enough to deplete hepatic glutathione, however, there is extensive arylation of hepatic macromolecules and cell death. This paper presents evidence that administration of glutathione-like nucleophiles, such as cysteamine, protects mice from arylation of hepatic macromolecules, hepatic necrosis, and death caused by the reactive acetaminophen metabolite. Additional studies indicate that glutathione may serve a similar protective function in man as in other animals. Thus, logical treatment of patients overdosed with acetaminophen might be based on cysteamine or other nucleophiles.
KW - Acetaminophen--toxicity-;
KW - Glutathione--therapy-;
KW - Toxicity--acetaminophen--hepatic, glutathione therapy, discussion;
KW - Antidotes--glutathione--therapy, acetaminophen hepatic toxicity, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Little, B. C.;
AU - Matta, R. J.;
AU - Zahn, T. P.;
T1 - Physiological and psychological effects of progesterone in man
CT - Physiological and psychological effects of progesterone in man
JO - J. Nerv. Ment. Dis.
JF - J. Nerv. Ment. Dis.
Y1 - 1974/10/01/
VL - 159
IS - Oct
SP - 256
EP - 262
AD - Laboratory of Psychology, National Institute of Mental Health, Bldg. 10 Room 2N-315, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-4041; Language: English; Chemical Name: Progesterone--57-83-0; References: 18; Journal Coden: JNMDAN; Human Indicator: Yes; Section Heading: Pharmacology
N2 - A study of the effects of exogenously administered progesterone in males was conducted to test the hypothesis that psychophysiological changes occuring during the female menstrual cycle are progesterone-dependent. Progesterone (10 mg/day) was administered daily to 6 men during either the second or third week (double-blind) of a 4-4.5 week period. Parameters of evaluation included: skin conductance, heart rate, respiration, body temperature, and performance on several tasks. Expected increases in heart rate and respiration and changes in mood were not observed, although other physiologic parameters were altered by the drug. The data suggest that factors other than progesterone may influence the psychophysiological changes associated with premenstrual tension.
KW - Progesterone--effects-;
KW - Methodology--progesterone--effects, physiological and psychological, in male, correlation to changes in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kirkpatrick, Charles H.
AU - Montes, Leopoldo F.
T1 - Chronic Mucocutaneous Candidiasis.
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
Y1 - 1974/10//
VL - 1
IS - 5
M3 - Article
SP - 211
EP - 229
SN - 03036987
AB - The lymphocyte transformation test is commonly employed as a correlate of delayed hypersensitivity in vitro. As a generalization it is a good correlate, although there are some exceptions. Venous blood is collected in heparin and lymphocytes are collected and placed in a culture with or without antigen. After an appropriate duration of incubation, the precursor of DNA, tritiated thymidine, is added to the cultures. The cells are then harvested and the radioactivity incorporated by the antigen-stimulated cultures and compare it to the counts in the unstimulated cultures. The difference in the counts reflects the increment of DNA synthesis by cells responding to the antigen.
KW - GENES
KW - MUCOCUTANEOUS leishmaniasis
KW - CANDIDIASIS
KW - HEPARIN
KW - DNA
KW - ANTIGENS
N1 - Accession Number: 11796159; Kirkpatrick, Charles H. 1 Montes, Leopoldo F. 2; Affiliation: 1: Head, Clinical Allergy and Hypersensitivity Section, Loboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014, U.S.A. 2: Professor of Dermatology and Associate Professor of Microbiology, University of Alabama in Birmingham Medical Center, Birmingham, Alabama 35294,U.S.A.; Source Info: 1974, Vol. 1 Issue 5, p211; Subject Term: GENES; Subject Term: MUCOCUTANEOUS leishmaniasis; Subject Term: CANDIDIASIS; Subject Term: HEPARIN; Subject Term: DNA; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-43876-011
AN - 2013-43876-011
AU - Attkisson, C. Clifford
AU - McIntyre, Marguerite H.
AU - Hargreaves, A.
AU - Harris, M. Robert
AU - Ochberg, Frank M.
T1 - A working model for mental health program evaluation.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1974/10//
VL - 44
IS - 5
SP - 741
EP - 753
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Attkisson, C. Clifford, Langley Porter Neuropsychiatric Institute, University of California, San Francisco, CA, US, 94143
N1 - Accession Number: 2013-43876-011. PMID: 4611231 Partial author list: First Author & Affiliation: Attkisson, C. Clifford; University of California, San Francisco, CA, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Program Evaluation. Minor Descriptor: Mental Health; Mental Health Programs. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Oct, 1974.
AB - This paper describes a conceptual model of human service program evaluation, and integrates three key components of the evaluation process: a) Levels of Evaluative Activity, b) Functional Roles of the Evaluator, and c) Program Information Capability. This model has been useful in assessing evaluation capability of mental health programs, and in suggesting itineraries for enhancing evaluation capacity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health programs
KW - program evaluation
KW - working model
KW - 1974
KW - Mental Health Program Evaluation
KW - Mental Health
KW - Mental Health Programs
KW - 1974
U1 - Sponsor: National Institute of Mental Health. Grant: HSM-43-72-105. Recipients: No recipient indicated
DO - 10.1111/j.1939-0025.1974.tb01152.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KOLB, HELGA
AU - FAMIGLIETTI, E. V.
T1 - Rod and Cone Pathways in the Inner Plexiform Layer of Cat Retina.
JO - Science
JF - Science
Y1 - 1974/10/04/
VL - 186
IS - 4158
M3 - Article
SP - 47
EP - 49
SN - 00368075
AB - In cat retina, rod bipolar terminials do not synapse on ganglioni cells but on two types of alnacrine cell (types I and 11). Cone bipolars synapse directly oil ganglion cells and on type I ainacrines. The type II amnacrine appears to play a special internuncial role between bipolars and ganglion cells in the rod systemn. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117949; KOLB, HELGA 1; FAMIGLIETTI, E. V. 1; Affiliations: 1: National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/ 4/1974, Vol. 186 Issue 4158, p47; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Shoulson, I.;
AU - Chase, T. N.;
T1 - Fenfluramine and dyskinesias
CT - Fenfluramine and dyskinesias
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/10/17/
VL - 291
IS - Oct 17
SP - 850
EP - 851
SN - 00284793
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 12-0722; Language: English; Chemical Name: Fenfluramine--458-24-2; Therapeutic Class: (28:20); AHFS Class: Anorexics fenfluramine; References: 5; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Joan Lentine
N2 - The effect of fenfluramine on the metabolism of serotonin and dopamine was studied in 7 patients with various neurologic disorders. The central turnover of these monoamines was estimated by the probenecid-loading technique. The probenecid-induced accumulation of the principal metabolite of serotonin, 5-hydroxyindoleacetic acid, in lumbar spinal fluid decreased from a placebo treatment level of 89 29 ng./ml. to 30 16 ng./ml. during the administration by mouth of 120 mg. of fenfluramine ( \LT/ 0.01). The concentration of homovanillic acid, the primary dopamine metabolite, however, showed no consistent change (p \GT/ 0.05). These observations suggest that the action of fenfluramine at therapeutic dose levels may relate to effects on serotonin-mediated function\M/possibly a direct stimulation of postsynaptic serotonergic receptors. Also, these results may implicate the serotonergic system in the pathogenesis of certain drug-induced dyskinesias.
KW - Fenfluramine--effects-;
KW - Anorexics--fenfluramine--effects, on metabolism of dopamine and serotonin, in patients with neurologic disorders;
KW - Mechanism of action--fenfluramine--effects, on metabolism of serotonin and dopamine, in patients with neurologic disorders;
KW - Drugs, adverse reactions--fenfluramine--dyskinesias, mechanism of action, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ledley, R. S.
AU - Chiro, G. Di
AU - Luessenhop, A. J.
AU - Twigg, H. L.
T1 - Computerized Transaxial X-ray Tomography of the Human Body.
JO - Science
JF - Science
Y1 - 1974/10/18/
VL - 186
IS - 4160
M3 - Article
SP - 207
EP - 212
SN - 00368075
N1 - Accession Number: 85118003; Ledley, R. S. 1; Chiro, G. Di 2,3; Luessenhop, A. J. 4; Twigg, H. L. 5; Affiliations: 1: President of the National Biomedical Research Foundation and professor of physiology biohysics, and radiology, Georgetown University, Washingtown, D.C. 20007; 2: Head of the section on neuorology, National Institutes of Health, Bethesda, Maryland 20014; 3: Clinical Professor of radiology, Georgetown University; 4: Chief of neurological surgery, Georgetown University; 5: Chairman of radiology, Geotgetown University; Issue Info: 10/18/1974, Vol. 186 Issue 4160, p207; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dinarello, C. A.;
AU - Wolff, S. M.;
AU - Goldfiner, S. E.;
AU - Dale, D. C.;
AU - Alling, D. W.;
T1 - Colchicine therapy for familial Mediterranean fever: double-blind trial
CT - Colchicine therapy for familial Mediterranean fever: double-blind trial
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/10/31/
VL - 291
IS - Oct 31
SP - 934
EP - 937
SN - 00284793
AD - National Institutes of Health, Bldg. 10, Room 11 N-232, Bethesda, Maryland 20014
N1 - Accession Number: 12-2096; Language: English; Chemical Name: Colchicine--64-86-8; References: 24; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Eleven patients with long standing familial Mediterranean fever were studied in a double-blind trial using daily colchicine or placebo. Separate courses of colchicine, 0.6 mg. tablets, and placebo were administered in random order. Each course consisted of one tablet taken 3 times a day for 28 days. If no attacks occurred during the 28-day period, the next course was begun. During 60 courses of placebo, 38 attacks of familial Mediterranean fever occurred. In contrast, during 60 courses of colchicine only 7 attacks occurred ( \LT/ 0.001, by chi-square test). The 7 attacks on colchicine were evenly distributed throughout the study period. Although the initial dose was 3 tablets daily, most patients were maintained on 2 tablets of colchicine/day. The efficacy of the drug in preventing attacks of familial Mediterranean fever was dose related. There were no major side effects from daily colchicine except frequent loose stools, which were correctable by reduction of the dose. This study demonstrates that daily colchicine is highly effective in preventing attacks in this disorder.
KW - Colchicine--fever-;
KW - Fever--colchicine--familial Mediterranean, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Murphy, D. L.;
AU - Beigel, A.;
T1 - Depression, elation, and lithium carbonate responses in manic patient subgroups
CT - Depression, elation, and lithium carbonate responses in manic patient subgroups
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/11/01/
VL - 31
IS - Nov
SP - 643
EP - 648
AD - Laboratory of Clinical Sciences, National Institute of Mental Health, NIH Clinical Center, 10-3S229, Bethesda, Maryland 20014
N1 - Accession Number: 12-5827; Language: English; Trade Name: Lithionate--Eskalith; Generic Name: Lithium carbonate; Lithium carbonate; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Oral lithium carbonate (Lithionate; Eskalith), 1.2-2.1 g/day, was administered to 26 of 30 manic depressant patients to determine the depressive elements observed on a quantitative behavioral rating scale during manic episodes. Of 15 patients who were experiencing manic episodes, 9 improved with lithium carbonate therapy. Most responders were in the subgroup of elated-grandiose patients. There were 17 episodes of depression and 6 patients received treatment during both types of episodes. Only 2 of 6 patients from the paranoid-destructive subgroup improved with lithium.
KW - Lithium carbonate--psychoses-;
KW - Psychotherapeutic agents--lithium carbonate--psychoses, manic-depressive, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sack, R. L.;
AU - Goodwin, F. K.;
T1 - Inhibition of dopamine-\b/-hydroxylase in manic patients
CT - Inhibition of dopamine-\b/-hydroxylase in manic patients
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1974/11/01/
VL - 31
IS - Nov
SP - 649
EP - 654
AD - Section of Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, Bldg. 10, Rm. 4S239, Bethesda, Maryland 20014
N1 - Accession Number: 13-0659; Language: English; Chemical Name: Fusaric acid--536-69-6; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents fusaric acid; References: 58; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Ronald E. Nagata, Jr.
N2 - In a double-blind controlled study with one depressed and 8 manic or hypomanic patients, fusaric acid was administered, 0.6 to 1.8 g daily, for 10 to 20 days to determine its behavioral effects and to measure its influence on laboratory tests. As a specific inhibitor of dopamine-\b/-hydroxylase (DBH) it decreases central norepinephrine without reducing dopamine. Increases in homovanillic acid, the major metabolite of dopamine, and decreases in CSF 3-methoxy 4-hydroxy-phenylglycol, the major metabolite of norepinephrine, were consistent with DBH inhibition. Behavioral effects of fusaric acid seemed to be dependent upon the pre-existing clinical state. Severe manic patients with evidence of pre-existing psychotic features became worse, while hypomanics showed no change or slight improvement.
KW - Fusaric acid--psychoses-;
KW - Psychotherapeutic agents--fusaric acid--psychoses, manic depressive, lack, effects, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Campbell, A.
AU - Campbell, A A
T1 - Beyond the demographic transition.
JO - Demography
JF - Demography
Y1 - 1974/11//
VL - 11
IS - 4
M3 - journal article
SP - 549
EP - 561
SN - 00703370
AB - The article discusses about demographic transition. Two major demographic movements have dominated population growth in the world during the past thirty years. First, is the decline of death rates in the developing countries, which has brought about unusually rapid population growth, and second is the rise and subsequent decline of birth rates in some developed countries. At most, demographers thought that there would be a moderate increase after the war to compensate for the interruption of family growth during the war-and, indeed, the word compensation has been used occasionally to characterize the resurgence of childbearing in the postwar period. The developed countries appear to have gone beyond the demographic transition and to have entered an era in which fertility fluctuates mainly in response to influences other than those that reduced birth rates during the preceding three centuries.
KW - VITAL statistics
KW - ECONOMIC development
KW - STATISTICS
KW - DEMOGRAPHIC transition
KW - SOCIAL indicators
KW - MORTALITY
KW - DEVELOPED countries
N1 - Accession Number: 16799052; Campbell, A. 1; Campbell, A A 2; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20014.; 2: Center for Population Research, National Institute of Child Health and Human Development, 20014, Bethesda, Maryland; Issue Info: Nov1974, Vol. 11 Issue 4, p549; Thesaurus Term: VITAL statistics; Thesaurus Term: ECONOMIC development; Thesaurus Term: STATISTICS; Subject Term: DEMOGRAPHIC transition; Subject Term: SOCIAL indicators; Subject Term: MORTALITY; Subject: DEVELOPED countries; Number of Pages: 13p; Document Type: journal article
L3 - 10.2307/2060470
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Butler, Robert N.
T1 - Mental health and aging. (cover story)
JO - Geriatrics
JF - Geriatrics
Y1 - 1974/11//
VL - 29
IS - 11
M3 - Article
SP - 59
EP - 60
SN - 0016867X
N1 - Accession Number: 17911344; Butler, Robert N. 1,2,3,4,5; Source Information: Nov1974, Vol. 29 Issue 11, p59; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 579
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Blank, Marie L.
T1 - Raising the age barrier to psychotherapy.
JO - Geriatrics
JF - Geriatrics
Y1 - 1974/11//
VL - 29
IS - 11
M3 - Article
SP - 143
EP - 148
SN - 0016867X
N1 - Accession Number: 17911351; Blank, Marie L. 1; Source Information: Nov1974, Vol. 29 Issue 11, p143; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3571
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Barry, David W.
AU - Schaff, Zsuzsa
AU - Grimley, Philip M.
AU - Hopps, Hope E.
AU - Aptekar, Robert
T1 - MORPHOLOGIC, BIOLOGIC, AND CYTOCHEMICAL ANALYSIS OF INTRACYTOPLASMIC PARTICLES FOUND IN CULTURED FIBROBLASTS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1974/11//
VL - 63
IS - 5
M3 - Article
SP - 407
EP - 410
SN - 0022202X
AB - Fibroblasts grown from one involved and seven uninvolved skin sites of patients with systemic lupus erythematosus (SLE), two patients with rheumatoid arthritis (RA), and one normal patient were examined by light, fluorescent, and electron microscopy. All failed to show evidence of virus-like particles or tubuloreticular structures previously observed in the endoplasmic reticulum of tissue from patients with SLE. Densely staining intracellular punctate bodies 250-500 A in diameter were tentatively identified by differential cytochemical staining as glycogen granules. Cultures from normal. SLE and RA patients showed identical susceptibility to infection with Newcastle disease virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - FIBROBLASTS
KW - RHEUMATOID arthritis
KW - ENDOPLASMIC reticulum
KW - GLYCOGEN
KW - NEWCASTLE disease virus
N1 - Accession Number: 12676570; Barry, David W. 1 Schaff, Zsuzsa 1 Grimley, Philip M. 1 Hopps, Hope E. 2 Aptekar, Robert 2; Affiliation: 1: Laboratory of Pathology, National Cancer Institute, NIH. 2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, NIH, Bethesda, Maryland 20014.; Source Info: Nov74, Vol. 63 Issue 5, p407; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: FIBROBLASTS; Subject Term: RHEUMATOID arthritis; Subject Term: ENDOPLASMIC reticulum; Subject Term: GLYCOGEN; Subject Term: NEWCASTLE disease virus; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12676570
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Litterst, C. L.;
AU - Mimnaugh, E. G.;
AU - Cowles, A. C.;
AU - Gram, T. E.;
AU - Guarino, A. M.;
T1 - Distribution of C14 lomustine (C14 CCNU)-derived radioactivity following intravenous administration of three potential clinical formulations to rabbits
CT - Distribution of C14 lomustine (C14 CCNU)-derived radioactivity following intravenous administration of three potential clinical formulations to rabbits
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/11/01/
VL - 63
IS - Nov
SP - 1718
EP - 1721
SN - 00223549
AD - Laboratory of Toxicology and the Membrane Transport Section, Experimental Therapeutics, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-4489; Language: English; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents lomustine; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution
KW - Lomustine--body distribution-;
KW - Drugs, body distribution--lomustine--intravenous, in rabbits;
KW - Metabolism--lomustine--body distribution, IV, in rabbits;
KW - Antineoplastic agents--lomustine--body distribution, IV, in rabbits;
KW - Formulations--lomustine--body distribution, IV, in rabbits;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dunham, L. J.;
AU - Sheets, R. H.;
AU - Morton, J.;
T1 - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
CT - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1974/11/01/
VL - 53
IS - Nov
SP - 1259
EP - 1269
SN - 00278874
AD - Laboratory of Pathology, NIH, National Cancer Institute, Dept. of Health, Education, and Public Health Service, U.S. Dept. of Health Education and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 12-4232; Language: English; Chemical Name: Arecoline--63-75-2; References: 28; Section Heading: Toxicity; Pharmacognosy
N2 - Attempts were made to develop a reliable test for the presence or absence of carcinogens in the environment. Certain plant materials suspected of affecting the development of esophageal cancer in man were applied to hamsters' upper GI tract, including cheek pouch, in several long term experiments. The materials tested, often with calcium hydroxide added, were 9 plants from Curacao used in native teas and remedies, a tobacco (used in snuff), and arecoline, present in betel quid. Lesions developing after treatment with \IT/Annona muricata, Heliotropium ternatum, Krameria ixina,\OK/ and \IT/Acacia villosa,\OK/ and with arecoline were a superficial spreading carcinoma of pouch epithelium, papillomas of esophagus (4) and advanced atypias (1 in pouch, 3 in esophagus). These lesions developed in relation to the cheeck pouch route of application only, whereas none resulted after ingestion of a concentrated tea (\IT/A. villosa\OK/), or when administered in the diet (\IT/A. muricate,\OK/ arecoline). The histologic types and distribution of the lesions in cheek pouch and esophagus suggest that they were caused by substances in the test materials tentatively presumed to be weaker or slower in action than the known chemical carcinogens.
KW - Arecoline--carcinogens-;
KW - Annona muricata--carcinogens--lesions, in hamster cheek pouch;
KW - Acacia villosa--carcinogens--lesions, in hamster cheek pouch;
KW - Heliotropium ternatum--carcinogens--lesions, in hamster cheek pouch;
KW - Krameria ixina--carcinogens--lesions, in hamster cheek pouch;
KW - Carcinogens--plants--Curacao, lesions, in hamster cheek pouch;
KW - Folk medicine--plants--Curacao, teas and remedies, carcinogens, in hamster cheek pouch;
KW - Toxicity--plants--Curacao, teas, remedies, lesions in hamster cheek pouch;
KW - Methodology--carcinogens--plants, detection using hamsters, cheek pouch lesions;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Segerling, M.;
AU - Ohanian, S.;
AU - Borsos, T.;
T1 - Effect of metabolic inhibitors on killing of tumor cells by antibody and complement
CT - Effect of metabolic inhibitors on killing of tumor cells by antibody and complement
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1974/11/01/
VL - 53
IS - Nov
SP - 1411
EP - 1413
SN - 00278874
AD - Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-5006; Language: English; Trade Name: Actinomycin D; Generic Name: Dactinomycin; Chemical Name: Dactinomycin--50-76-0 Puromycin--53-79-2 Mitomycin--50-07-7 Hydroxyurea--127-07-1; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mitomycin (10:00); AHFS Class: Antineoplastic agents dactinomycin (10:00); AHFS Class: Antineoplastic agents hydroxyurea (10:00); AHFS Class: Antineoplastic agents puromycin; References: 11; Section Heading: Pharmacology
N2 - Resistance of guinea pig hepatoma cells (line-10) to killing by rabbit antibody and guinea pig complement was reduced by pretreatment of the cells with nontoxic doses of actinomycin D (dactinomycin), puromycin, mitomycin and hydroxyurea.
KW - Dactinomycin--hepatoma-;
KW - Puromycin--hepatoma-;
KW - Mitomycin--hepatoma-;
KW - Hydroxyurea--hepatoma-;
KW - Antineoplastic agents--mitomycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW - Antineoplastic agents--dactinomycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW - Antineoplastic agents--hydroxyurea--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
KW - Antineoplastic agents--puromycin--hepatoma, guinea pig cells, reduced resistance to killing by rabbit antibody and guinea pig complement;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brady, R. O.;
AU - Pentchev, P. G.;
AU - Gal, A. E.;
AU - Hibbert, S. R.;
AU - Dekaban, A. S.;
T1 - Replacement therapy for inherited enzyme deficiency: use of purified glucocerebrosidase in Gaucher's disease
CT - Replacement therapy for inherited enzyme deficiency: use of purified glucocerebrosidase in Gaucher's disease
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/11/07/
VL - 291
IS - Nov 7
SP - 989
EP - 993
SN - 00284793
AD - Bldg. 10, Rm. 3D-03, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-2674; Language: English; Therapeutic Class: (44:00); AHFS Class: Enzymes glucocerebrosidase; References: 22; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - The effect of IV administration of glucocerebrosidase isolated from human placenta was investigated in 2 patients with Gaucher's disease who are deficient in this enzyme. The first received one injection of 1.5 x 10\SU/6\BS/ units of glucocerebrosidase, and the second an injection of 1.65 x 10\SU/6\BS/ units on 2 successive days. Liver biopsies were obtained before and 24 hours after injection of enzyme. Glucocerebroside in the liver of the first patient decreased from 702 to 519 mcg/g and from 1634 to 1214 mcg/g in the second after infusion of glucocerebrosidase. The quantity of glucocerebroside in erythrocytes of the 2 patients before infusion was 7.4 and 6.2 mcg/ml of cells respectively and 2.9 and 2.6 mcg/ml of cells 72 hours afterward. These findings indicate that exogenous glucocerebrosidase causes definite decreased in the quantity of accumulated lipid in patients with Gaucher's disease.
KW - Glucocerebrosidase--Gaucher's disease-;
KW - Gaucher's disease--glucocerebrosidase--therapy, in patients;
KW - Enzymes--glucocerebrosidase--Gaucher's disease, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - STANDLEY, KAY
AU - SOULE III, A. BRADLEY
AU - COPANS, STUART A.
AU - DUCHOWNY, MICHAEL S.
T1 - Local-Regional Anesthesia during Childbirth: Effect on Newborn Behaviors.
JO - Science
JF - Science
Y1 - 1974/11/15/
VL - 186
IS - 4164
M3 - Article
SP - 634
EP - 635
SN - 00368075
AB - Administration of local-regional anesthesia during norgnal deliveries was correlated significantly with newborn behaviors as evaluated by the Brazelton neonatal assessment scale. Three days after birth, infants whose mothers received local-regional anesthesia were more irritable and motorically less mature than those infants whose mothers were not medicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85179049; STANDLEY, KAY 1; SOULE III, A. BRADLEY 1; COPANS, STUART A. 1; DUCHOWNY, MICHAEL S. 1; Affiliations: 1: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 11/15/1974, Vol. 186 Issue 4164, p634; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dale, D. C.;
AU - Fauci, A. S.;
AU - Wolfee, S. M.;
T1 - Alternate-day prednisone: leukocyte kinetics and susceptibility to infections
CT - Alternate-day prednisone: leukocyte kinetics and susceptibility to infections
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/11/28/
VL - 291
IS - Nov 28
SP - 1154
EP - 1158
SN - 00284793
AD - Bldg. 10, Room 11B-13, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-1801; Language: English; Chemical Name: Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone; References: 35; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The effects of alternate day and daily prednisone on leukocyte kinetics were studied in 20 patients with inflammatory diseases to investigate the mechanisms of corticosteroid-induced susceptibility to infections. The mean ( 1 SEM) prednisone dose for the day on drug of the patients on alternate day therapy was 37.5 6.1 mg.; the average dose for the daily therapy patients was 60.7 16.3 mg./day. With daily prednisone, both neutrophil and monocyte inflammatory responses were significantly decreased. In patients on alternate day prednisone, who were studied during the day on which prednisone was administered, neutrophilia and monocytopenia occurred, and cutaneous inflammatory responses of monocytes, but not of neutrophils, were significantly reduced. On the day of therapy of alternate day prednisone and with daily therapy the half-life of labeled blood neutrophils was significantly prolonged, and the prolongation was proportional to the dose of the drug given. In contrast, in patients maintained on alternate day prednisone therapy and studied on the day off drug, leukocyte counts, inflammatory responses and neutrophil half-life were normal.
KW - Prednisone--dosage schedules-;
KW - Dosage schedules--prednisone--effects, on leukocyte kinetics, in inflammatory disease patients;
KW - Steroids, cortico---prednisone--dosage schedules, effects on leukocyte kinetics, in inflammatory disease patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fowler, B. A.;
AU - Weissberg, J. B.;
T1 - Arsine poisoning
CT - Arsine poisoning
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1974/11/28/
VL - 291
IS - Nov 28
SP - 1171
EP - 1174
SN - 00284793
AD - Environmental Toxicology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709
N1 - Accession Number: 12-2574; Language: English; References: 75; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Joan Lentine
N2 - A review of arsine gas poisoning with emphasis on its clinical features, pathogenesis and treatment, is presented. Recent attempts to use geothermal and fossil fuel energy sources high in arsenic content may increase the frequency of arsine exposure.
KW - Arsine--gases-;
KW - Gases--arsine--poisoning, and therapy, discussion;
KW - Poisoning--arsine--gases, and therapy, discussion;
KW - Toxicity, environmental--arsine--gases, poisoning, and therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - DE CLERCQ, E.
AU - TORRENCE, P. F.
AU - WITKOP, B.
AU - STEWART II, W. E.
AU - DE SOMER, P.
T1 - Interferon Induction: Tool for Establishing Interactions among Homopolyribonucleotides.
JO - Science
JF - Science
Y1 - 1974/11/29/
VL - 186
IS - 4166
M3 - Article
SP - 835
EP - 837
SN - 00368075
AB - Hitherto unrecognized interactions between homopolyribonucleotides and complexes thereof are suggested by interferon induction data obtained in a highly sensitive assay system of primary rabbit kidney cell cultures superinduced by metabolic inhibitors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118200; DE CLERCQ, E. 1; TORRENCE, P. F. 2; WITKOP, B. 2; STEWART II, W. E. 3; DE SOMER, P. 3; Affiliations: 1: Rega Institute for Medical Research, University of Leuven, Leuven, Belgium; 2: Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 3: Rega Institute for Medical Research; Issue Info: 11/29/1974, Vol. 186 Issue 4166, p835; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bachrach, Leona L.
T1 - Developing Objectives in Community Mental Health Planning.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/12//
VL - 64
IS - 12
M3 - Article
SP - 1162
EP - 1163
PB - American Public Health Association
SN - 00900036
AB - The article discusses the conceptual framework for embarking on the design of objectives for a community mental health plan, where a number of administratively independent facilities provide mental health services to the population. Each component unit must determine and submit its own goals and objectives in designing a mental health plan subscribed to by various service organizations. The health plan's objectives should be proposed with due recognition for three characteristics, including relevancy, practicability and measurability.
KW - Public health
KW - Goal (Psychology)
KW - Motivation (Psychology)
KW - Mental health planning
KW - Mental health services
KW - Service industries
KW - Relevance
KW - Medical care
KW - Medical policy
KW - Community
KW - Mental health
KW - Objectives
KW - Planning
N1 - Accession Number: 7971405; Bachrach, Leona L. 1; Affiliations: 1: Survey and Reports Branch, Division of Biometry, National Institute of Mental Health, 5600 Fishers Lane, Room 18-C-17, Rockville, Maryland 20852; Issue Info: Dec1974, Vol. 64 Issue 12, p1162; Thesaurus Term: Public health; Subject Term: Goal (Psychology); Subject Term: Motivation (Psychology); Subject Term: Mental health planning; Subject Term: Mental health services; Subject Term: Service industries; Subject Term: Relevance; Subject Term: Medical care; Subject Term: Medical policy; Author-Supplied Keyword: Community; Author-Supplied Keyword: Mental health; Author-Supplied Keyword: Objectives; Author-Supplied Keyword: Planning; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 423850 Service Establishment Equipment and Supplies Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chu, Sherwood C.
AU - Berman, Mones
T1 - An Exponential Method for the Solution of Systems of Ordinary Differential Equations.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1974/12//
VL - 17
IS - 12
M3 - Article
SP - 699
EP - 702
SN - 00010782
AB - An explicit, coupled, single-step method for the numerical solution of initial value problems for systems of ordinary differential equations is presented. The method was designed to be general purpose in nature but to be especially efficient when dealing with stiff systems of differential equations. it is, in general, second order except for the case of a linear system with constant coefficients and linear forcing terms; in that case, the method is third order. It has been implemented and put to routine usage in biological applications—where stiffness frequently appears—with favorable results. When compared to a standard fourth order Runge-Kutta implementation, computation time required by this method has ranged from comparable for certain nonstiff problems to better than two orders of magnitude faster for some highly stiff systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIFFERENTIAL equations -- Numerical solutions
KW - EXPONENTIAL functions
KW - DIFFERENTIAL equations
KW - CALCULUS
KW - BOUNDARY value problems
KW - LINEAR systems
KW - STIFF computation (Differential equations)
KW - RUNGE-Kutta formulas
KW - initial value problems
KW - numerical solution
KW - ordinary differential equations
KW - stiff systems
N1 - Accession Number: 5246460; Chu, Sherwood C. 1 Berman, Mones 1; Affiliation: 1: National Cancer Institute, NIH.; Source Info: Dec1974, Vol. 17 Issue 12, p699; Subject Term: DIFFERENTIAL equations -- Numerical solutions; Subject Term: EXPONENTIAL functions; Subject Term: DIFFERENTIAL equations; Subject Term: CALCULUS; Subject Term: BOUNDARY value problems; Subject Term: LINEAR systems; Subject Term: STIFF computation (Differential equations); Subject Term: RUNGE-Kutta formulas; Author-Supplied Keyword: initial value problems; Author-Supplied Keyword: numerical solution; Author-Supplied Keyword: ordinary differential equations; Author-Supplied Keyword: stiff systems; Number of Pages: 4p; Document Type: Article
L3 - 10.1145/361604.361627
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chu, Sherwood C.
AU - Berman, Mones
T1 - An Exponential Method for the Solution of Systems of Ordinary Differential Equations.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1974/12//
VL - 17
IS - 12
M3 - Article
SP - 699
EP - 702
SN - 00010782
AB - An explicit, coupled, single-step method for the numerical solution of initial value problems for systems of ordinary differential equations is presented. The method was designed to be general purpose in nature but to be especially efficient when dealing with stiff systems of differential equations. it is, in general, second order except for the case of a linear system with constant coefficients and linear forcing terms; in that case, the method is third order. It has been implemented and put to routine usage in biological applications—where stiffness frequently appears—with favorable results. When compared to a standard fourth order Runge-Kutta implementation, computation time required by this method has ranged from comparable for certain nonstiff problems to better than two orders of magnitude faster for some highly stiff systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIFFERENTIAL equations
KW - NUMERICAL solutions
KW - EXPONENTIAL functions
KW - CALCULUS
KW - BOUNDARY value problems
KW - LINEAR systems
KW - STIFF computation (Differential equations)
KW - RUNGE-Kutta formulas
KW - initial value problems
KW - numerical solution
KW - ordinary differential equations
KW - stiff systems
N1 - Accession Number: 5246460; Chu, Sherwood C. 1; Berman, Mones 1; Affiliations: 1: National Cancer Institute, NIH.; Issue Info: Dec1974, Vol. 17 Issue 12, p699; Thesaurus Term: DIFFERENTIAL equations; Subject Term: NUMERICAL solutions; Subject Term: EXPONENTIAL functions; Subject Term: CALCULUS; Subject Term: BOUNDARY value problems; Subject Term: LINEAR systems; Subject Term: STIFF computation (Differential equations); Subject Term: RUNGE-Kutta formulas; Author-Supplied Keyword: initial value problems; Author-Supplied Keyword: numerical solution; Author-Supplied Keyword: ordinary differential equations; Author-Supplied Keyword: stiff systems; Number of Pages: 4p; Document Type: Article
L3 - 10.1145/361604.361627
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=5246460&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Pearlin, Leonard I.
T1 - The World of the Urban Working Class.
JO - Political Science Quarterly (Academy of Political Science)
JF - Political Science Quarterly (Academy of Political Science)
Y1 - 1974///Winter74/75
VL - 89
IS - 4
M3 - Book Review
SP - 855
EP - 856
SN - 00323195
AB - Reviewed: The World of the Urban Working Class. Fried, Marc.
KW - WORKING class
KW - NONFICTION
KW - URBAN renewal
KW - NARRATIVES
KW - NEIGHBORHOODS
KW - Fried, Marc
KW - Massachusetts (Boston, West End)
KW - FRIED, Marc
KW - WORLD of the Urban Working Class, The (Book)
N1 - Accession Number: 24245425; Pearlin, Leonard I. 1; Affiliations: 1 : National Institute of Mental Health; Source Info: Winter74/75, Vol. 89 Issue 4, p855; Note: Publication Information: Lawrence, Mass.: Harvard U. Pr., 1973. 410 pp.; Historical Period: 1950 to 1969; Subject Term: WORKING class; Subject Term: NONFICTION; Subject Term: URBAN renewal; Subject Term: NARRATIVES; Subject Term: NEIGHBORHOODS; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - VAUGHAN, MARY K.
AU - VAUGHAN, GEORGE M.
AU - KLEIN, DAVID C.
T1 - Arginine Vasotocin: Effects on Development of Reproductive Organs.
JO - Science
JF - Science
Y1 - 1974/12/06/
VL - 186
IS - 4167
M3 - Article
SP - 938
EP - 939
SN - 00368075
AB - Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118244; VAUGHAN, MARY K. 1; VAUGHAN, GEORGE M. 1; KLEIN, DAVID C. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 12/ 6/1974, Vol. 186 Issue 4167, p938; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEIGHT, FORREST F.
AU - PETZOLD, GARY
AU - GREENGARD, PAUL
T1 - Guanosine 3',5'-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission.
JO - Science
JF - Science
Y1 - 1974/12/06/
VL - 186
IS - 4167
M3 - Article
SP - 942
EP - 944
SN - 00368075
AB - Brief stimulation of cholinergic preganglionic nerve fibers resulted in an increase in guanosine 3',5'-monophosphate (cyclic GMP) in the bullfrog sympathetic ganglion. When the release of synaptic transmitter was prevented by a high-magnesium, low-calcium Ringer solution, stimulation of preganglionic nerve fibers did not increase cyclic GMP in the ganglion. The increase in cyclic GMP caused by preganglionic stimulation was also blocked by the muscarinic antagonist, atropine. The data indicate that the increase in cyclic GMP is associated with synaptic transmission and support the possibility that cyclic GMP may mediate the postsynaptic action of acetylcholine at muscarinic cholinergic synapses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118247; WEIGHT, FORREST F. 1; PETZOLD, GARY 2; GREENGARD, PAUL 2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; Issue Info: 12/ 6/1974, Vol. 186 Issue 4167, p942; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Carman, J. S.;
AU - Post, R. M.;
AU - Teplitz, T. A.;
AU - Goodwin, F. K.;
T1 - Divalent cations in predicting antidepressant response to lithium
CT - Divalent cations in predicting antidepressant response to lithium
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1974/12/14/
VL - 2
IS - Dec 14
SP - 1454
SN - 00237507
AD - Adult Psychiatry Branch and Section on Psychiatry, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 12-3191; Language: English; Chemical Name: Lithium--7439-93-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium; References: 19; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Results of preliminary studies in patients have shown that the pre-treatment calcium/magnesium ratio was significantly related to the subsequent antidepressant response to lithium.
KW - Lithium--therapy-;
KW - Psychotherapeutic agents--lithium--therapy, response, effects of pretreatment calcium/magnesium, in patients;
KW - Methodology--lithium--therapy, response, effects of pretreatment calcium/magnesium ratio, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3191&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dekaban, A. S.;
AU - Steusing, J. K.;
T1 - Menkes' kinky hair disease treated with subcutaneous copper sulfate
CT - Menkes' kinky hair disease treated with subcutaneous copper sulfate
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1974/12/21/
VL - 2
IS - Dec 21
SP - 1523
SN - 00237507
AD - Developmental and Metabolic Neurology Branch, N.I.N.D.S., National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-2372; Language: English; Chemical Name: Cupric sulfate--7758-99-8; References: 8; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - The treatment of Menkes' kinky hair disease in 2 infants using a SC infusion of 1-2 mg of copper sulfate in 25-50 ml of saline (0.04 mg/ml) is reported. The infusions were given by slow-drip over 2 hours. The infusions were administered every 3-4 days in 4 alternate sites. No untoward local effects or complications were encountered during 5 months of this therapy.
KW - Cupric sulfate--Menkes' kinky hair disease-;
KW - Drug administration--routes--cupric sulfate, SC infusion, Menkes' disease, in infants;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2372&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
AU - Winokur, S. K.;
T1 - Immunosuppressive and cytotoxic chemotherapy: long term complications
CT - Immunosuppressive and cytotoxic chemotherapy: long term complications
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1975/01/01/
VL - 82
IS - Jan
SP - 84
EP - 95
SN - 00034819
AD - Reprints: Div. of Medical Oncology, Georgetown Univ. Hospital, Washington, D.C. 20007
AD - Clinical Pharmacology-Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-5486; Language: English; References: 160; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Patrick Moran
N2 - Complications of long term immunosuppressive and cytotoxic chemotherapy in patients are reviewed. The primary complication is cumulative organ toxicity which is often insidious in onset and which may not be apparent clinically until the damage has become severe and irreversible.
KW - Immunosuppressive agents--toxicity--long term, review, in patients;
KW - Antineoplastic agents--toxicity--long term, review, in patients;
KW - Toxicity--immunosuppressive agents--long term, review, in patients;
KW - Toxicity--antineoplastic agents--long term, review, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Merrill, J.;
AU - Grezo, A. F.;
AU - Zimbler, H.;
AU - Brereton, H. D.;
AU - Lamberg, J. D.;
AU - \ET/;
T1 - Adriamycin and radiation: synergistic cardiotoxicity
CT - Adriamycin and radiation: synergistic cardiotoxicity
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1975/01/01/
VL - 82
IS - Jan
SP - 122
EP - 123
SN - 00034819
AD - Radiation Oncology Branch, Div. of Cancer Biology and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-5848; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Patrick Moran
N2 - Severe cardiomyopathy with irreversible congestive heart failure is reported in 2 children being treated with 500 to 550 mg/sq m adriamycin (doxorubicin) in conjunction with therapeutic radiation to the thoracic spine and lungs. It is suggested that a synergistic radiation-adriamycin cardiotoxicity is possible in patients receiving such therapy.
KW - Doxorubicin--interactions-;
KW - Radiation--interactions--doxorubicin, cardiotoxicity, in children;
KW - Drug interactions--doxorubicin and radiation--cardiotoxicity, in children;
KW - Drug interactions--radiation and doxorubicin--cardiotoxicity, in children;
KW - Antineoplastic agents--doxorubicin--interactions, radiation, cardiotoxicity, in children;
KW - Toxicity--doxorubicin--and radiation, cardiotoxcity, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pomeroy, T. C.;
AU - Johnson, R. E.;
T1 - Combined modality therapy of Ewing's sarcoma
CT - Combined modality therapy of Ewing's sarcoma
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1975/01/01/
VL - 35
IS - Jan
SP - 36
EP - 47
AD - Radiation Branch, DCBD, National Cancer Institute, Bldg. 10, Rm. R3B38, Bethesda, Maryland 20014
N1 - Accession Number: 12-4886; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8 Cyclophosphamide--6055-19-2 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents cyclophosphamide and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine and cyclophosphamide; References: 33; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Michael M. Alexander
N2 - The management of Ewing's sarcoma by the use of aggressive adjunctive chemotherapy in 66 patients is discussed. Therapy consisted of local irradiation of the primary site combined with adjuvant regimens of progressively more intense systemic chemotherapy. Actuarial survival rates for the total series show a 56% 2-year survival and a 35% 5-year survival. The 43 patients with clinically detectable metastases had a better survival rate. The current protocol included alternating high doses of adriamycin (doxorubicin) with cyclophosphamide plus vincristine and provided improved disease-free survival as compared with previous protocols.
KW - Doxorubicin--Ewing's sarcoma-;
KW - Cyclophosphamide--and vincristine-;
KW - Vincristine--and cyclophosphamide-;
KW - Antineoplastic agents--doxorubicin--and cyclophosphamide and vincristine, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW - Antineoplastic agents--cyclophosphamide and vincristine--and doxorubicin, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW - Combined therapy--cyclophosphamide and vincristine--and doxorubicin, alternately, with radiation in Ewing's sarcoma patients;
KW - Combined therapy--vincristine and cyclophosphamide--and doxorubicin, alternately, with radiation in Ewing's sarcoma patients;
KW - Antineoplastic agents--vincristine and cyclophosphamide--and doxorubicin, alternately, therapy, with radiation in Ewing's sarcoma patients;
KW - Antineoplastic agents--radiation--and doxorubicin, alternately with cyclophosphamide and vincristine, therapy, Ewing's sarcoma patients;
KW - Radiation--Ewing's sarcoma--and doxorubicin, alternately with cyclophosphamide and vincristine, therapy, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4886&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Young, R. C.;
AU - Canellos, G. P.;
T1 - Combination versus single agent chemotherapy: review of the basis for selection of drug treatment of cancer
CT - Combination versus single agent chemotherapy: review of the basis for selection of drug treatment of cancer
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1975/01/01/
VL - 35
IS - Jan
SP - 98
EP - 10
AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-4386; Language: English; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
KW - Rational therapy--antineoplastic agents--combined, comparison, single agent, discussion, in patients;
KW - Antineoplastic agents--rational therapy--combined, comparison, single agent, discussion, in patients;
KW - Combined therapy--antineoplastic agents--comparison, single agents, rational therapy, discussion, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Friedman, R B
AU - Pestaner, L C
AU - Young, D.s.
T1 - Laboratory oriented computerized drug information systems
JO - Drug Information Journal 9, 182-189 (1975 May-september). 6 Ref
JF - Drug Information Journal 9, 182-189 (1975 May-september). 6 Ref
Y1 - 1975///
M3 - Book Chapter
AB - The structure and uses of the computerized listing of abnormal and unusual drug effects (claude), developed by the national institutes of health, are discussed. Claude was developed to facilitate the correct interpretation of laboratory data by physicians and clinical laboratory scientists. The data base contains approximately 17,500 effects, both in vivo and in vitro, for 1500 drugs on laboratory tests.
N1 - Accession Number: ISTA1200298; Friedman, R B 1; Pestaner, L C; Young, D.s. 1; Affiliations: 1 : Clinical Pathology Department, National Institutes Of Health, Bethesda, Maryland; Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Bellicha, T C
T1 - Targeted information concept. the national clearinghouse for alcohol information
JO - Drug Information Journal 9, 199-205 (1975 May-september)
JF - Drug Information Journal 9, 199-205 (1975 May-september)
Y1 - 1975///
M3 - Book Chapter
AB - The purpose, organization, and operation of the services of the national clearinghouse for alcohol information are detailed. Problems in the acquisition, classification, and dissemination of alcohol related information are discussed, as well as methods of identifying potential users of this specialized collection.
N1 - Accession Number: ISTA1200384; Bellicha, T C 1; Affiliations: 1 : National Institute On Alcohol Abuse And Alcoholism, Gaithersburg, Maryland; Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Leeds, A A
T1 - International reference centers network-an unusual information resource
JO - Drug Information Journal 9, 219-223 (1975 May-september)
JF - Drug Information Journal 9, 219-223 (1975 May-september)
Y1 - 1975///
M3 - Book Chapter
AB - The organization, publications, and activities of the international reference centers network for information on psychotropic drugs are discussed as a model system for international cooperation in the exchange of scientific information.
N1 - Accession Number: ISTA1200998; Leeds, A A 1; Affiliations: 1 : International Reference Center For Information On Psychotropic Drugs, National Institute Of Mental Health, Rockville, Maryland; Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Makinodan, Takashi
T1 - Will revitalized cells perk up immune activity in older persons?
JO - Geriatrics
JF - Geriatrics
Y1 - 1975/01//
VL - 30
IS - 1
M3 - Article
SP - 35
EP - 37
SN - 0016867X
N1 - Accession Number: 17729114; Makinodan, Takashi 1; Source Information: Jan1975, Vol. 30 Issue 1, p35; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 893
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Davis, Howard R
AU - Salasin, Susan E
T1 - The utilization of evaluation
JO - In Struening, Elmer L.: Guttentag, Marcia. Handbook Of Evaluation Research. Vol. 1. 1975. Sage Publications, Inc., Beverly Hills, California. P. 621-666. 69 Ref. See Isa 77-3957/y
JF - In Struening, Elmer L.: Guttentag, Marcia. Handbook Of Evaluation Research. Vol. 1. 1975. Sage Publications, Inc., Beverly Hills, California. P. 621-666. 69 Ref. See Isa 77-3957/y
Y1 - 1975///
M3 - Book Chapter
AB - The winds and currents, the array of forces, impinging on evaluation utilization are examined. An approach to predicting their influence on a given evaluation is considered, and a guideline for use by evaluators who may wish to enhance their contributions to the destinies of the cause they serve is proposed. It is held that: 1) evaluation provides great hope for ultimate beneficiaries of social programs; 2) effective utilization of evaluation is essential; 3) the destines of evaluation are, to some extent, predictable; 4) evaluators should consider extending their role to change consultation; 5) one's professional services can be based on a vast body of information on change and models of conceptualization; 6) utilization of evaluation may be achieved through the human approach to organizational change; 7) a victory technique may represent a schema to consider in trying the evaluator change consultant role.
N1 - Accession Number: ISTA1203608; Davis, Howard R 1; Salasin, Susan E; Affiliations: 1 : National Institute Of Mental Health; Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Hoel, D. G.;
AU - Gaylor, D. W.;
AU - Kirschstein, R. L.;
AU - Saffiotti, U.;
AU - Schneiderman, M. A.;
T1 - Estimation of risks of irreversible delayed toxicity
CT - Estimation of risks of irreversible delayed toxicity
JO - J. Toxicol. Environ. Health
JF - J. Toxicol. Environ. Health
Y1 - 1975/01/01/
VL - 1
IS - Jan
SP - 133
EP - 151
AD - National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina
N1 - Accession Number: 13-2397; Language: English; References: 29; Publication Type: Review; Journal Coden: JTEHD6; Section Heading: Methodology
N2 - The current statistical methods used to establish dose-response relationships for irreversible self-replicating toxic effects (i.e., carcinogenesis) in laboratory animals and extrapolation of these data to man are reviewed. The method or procedure for estimating human risk based on animal studies is basically carried out in 4 sequential steps: (1) Design and/or assessment of laboratory experiments as to quality and biological appropriateness; (2) statistical extrapolation of the experimental results to low dose levels; (3) extrapolation of the estimated results in animals at the low level to man; and (4) assessment of the risk to man based upon experimental data. Information about each of these steps is discussed as is the type of research to improve the quality of the entire statistical procedure.
KW - Methodology--toxicity--statistics, review;
KW - Statistics--toxicity--methodology, review;
KW - Toxicity--statistics--methodology, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rall, D. P.;
T1 - Candidate drugs for carcinogenic property studies: procedures
CT - Candidate drugs for carcinogenic property studies: procedures
JO - Journal of Clinical Pharmacology (USA)
JF - Journal of Clinical Pharmacology (USA)
Y1 - 1975/01/01/
VL - 15
IS - Jan
SP - 1
EP - 4
SN - 00912700
AD - National Institute of Environmental Health Sciences, NIH Research Triangle Park, North Carolina 27709
N1 - Accession Number: 13-1781; Language: English; References: 4; Journal Coden: JCPCBR; Section Heading: Methodology; Abstract Author: Walter Howard
N2 - New drugs are needed, and with respect to carcinogenesis, quick presumptive tests must be developed which will enable us to rapidly identify those compounds that are most likely to cause trouble. Closer attention to toxicity studies may enable the researcher to pick up hints about compounds that may have a carcinogenic effect. Lifetime rodent studies on all drugs in clinical usage are needed, and a much more advanced adverse drug reaction surveillance system should be implemented, including a record linkage system which allows patient followup, with those patients who have been exposed to the drugs in question. If programs like this can be developed over the next few years, the output of valuable new agents will be increased and, at the same time, it will be possible to reduce or minimize the danger to the patient.
KW - Methodology--toxicity--tests, carcinogenicity, drugs, new, and those in clinical practice;
KW - Toxicity--drugs--carcinogens, new, and those in clinical practice;
KW - Carcinogens--tests--methodology, drugs, new and those in clinical practice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Weisburger, E. K.;
T1 - Critical evaluation of the methods used for determining carcinogenicity
CT - Critical evaluation of the methods used for determining carcinogenicity
JO - Journal of Clinical Pharmacology (USA)
JF - Journal of Clinical Pharmacology (USA)
Y1 - 1975/01/01/
VL - 15
IS - Jan
SP - 5
EP - 5
SN - 00912700
AD - Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-2111; Language: English; Chemical Name: Azathioprine--446-86-6 Cyclophosphamide--6055-19-2 Methotrexate--59-05-2; References: 76; Publication Type: Review; Journal Coden: JCPCBR; Section Heading: Methodology
N2 - Methods currently employed for evaluating the possible carcinogenic potential of environmental compounds and contemporary antineoplastic agents, including, cyclophosphamide, azathioprine, and methotrexate, have been reviewed.
KW - Azathioprine--methodology-;
KW - Cyclophosphamide--methodology-;
KW - Methotrexate--methodology-;
KW - Carcinogens--methodology--review;
KW - Toxicity, environmental--carcinogens--methodology, review;
KW - Methodology--carcinogens--review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-2111&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hoover, R.;
AU - Fraumeni, J. F.;
T1 - Drugs in clinical use which cause cancer
CT - Drugs in clinical use which cause cancer
JO - Journal of Clinical Pharmacology (USA)
JF - Journal of Clinical Pharmacology (USA)
Y1 - 1975/01/01/
VL - 15
IS - Jan
SP - 16
EP - 23
SN - 00912700
AD - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-1782; Language: English; References: 51; Journal Coden: JCPCBR; Human Indicator: Yes; Section Heading: Methodology; Abstract Author: Walter Howard
N2 - As different conditions are added to therapeutic indications for currently used drugs, new assessments of their carcinogenic potential must be made. Carcinogenicity tests have become much more advanced and accurate. It seems likely that some decisions about carcinogenic potential of drugs can now be made on the basis of expertise provided by laboratory scientists and epidemiologists, rather than waiting for long term human effects to appear.
KW - Methodology--toxicity--carcinogens, drugs, studies;
KW - Toxicity--carcinogens--studies, methodology;
KW - Carcinogens--drugs--studies, methodology;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Korn, Edward D
T1 - Availability of grant applications
JO - Science 190(4216), 736 (1975 November 21). 0 Ref. See Isa 76-803/r
JF - Science 190(4216), 736 (1975 November 21). 0 Ref. See Isa 76-803/r
Y1 - 1975///
M3 - Book Chapter
AB - In the wake of district of columbia court of appeals decision permitting scientists access to research grant applications of others under the freedom of information act, the author urges colleagues on the nih/nimh (national institutes of health/national institute of mental health) staff to abstain voluntarily from requesting grant application copies, because of adverse effects on the peer review system and on research progress.
N1 - Accession Number: ISTA1100741; Korn, Edward D 1; Affiliations: 1 : Inter-assembly Council, National Institutes Of Health/national Institutes Of Mental Health; Source Info: 1975; Note: Update Code: 1100; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2006-06270-018
AN - 2006-06270-018
AU - Yarrow, Leon J.
T1 - Child Development, Psychodynamics, and the Law.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1975/01//
VL - 20
IS - 1
SP - 25
EP - 27
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06270-018. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, US. Release Date: 20061106. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Foster Parents; Laws; Psychodynamics. Minor Descriptor: Child Custody. Classification: Childrearing & Child Care (2956); Civil Rights & Civil Law (4210). Population: Human (10). Reviewed Item: Goldstein, Joseph; Freud, Anna; Solnit, Albert J. Beyond the Best Interests of the Child=New York: Free Press, 1973. Pp. xiii + 176. $7.95 cloth; $1.95 paper; 1973. Page Count: 3. Issue Publication Date: Jan, 1975.
AB - Reviews the book, Beyond the Best Interests of the Child by Joseph Goldstein, Anna Freud, and Albert J. Solnit (see record [rid]1974-10899-000[/rid]). Considers the nature of the relationship between the child and the custodian, whether biological, psychological, adoptive, or foster parent. Data concerning the child's sense of time and need for continuity of relationships are discussed. Guidelines and their implications for the laws of child placement are presented. The authors attempt to translate psychodynamic principles of growth and development into procedural guides for making decisions about a child's placement in foster care, adoption, or custody in divorce proceedings. The clarity and succinctness of this book are refreshing and make for easy reading. It has, however, a deceptive quality of simplicity The economy of words leaves much to interpretation; there is too little elaboration of controversial ideas. This stimulating essay opens up many important issues, but it is only a beginning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - foster parents
KW - laws
KW - psychodynamics
KW - 1975
KW - Foster Parents
KW - Laws
KW - Psychodynamics
KW - Child Custody
KW - 1975
U2 - Goldstein, Joseph; Freud, Anna; Solnit, Albert J. (1973); Beyond the Best Interests of the Child; New York: Free Press, 1973. Pp. xiii + 176. $7.95 cloth; $1.95 paper
DO - 10.1037/0013019
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 83985710
T1 - Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti's syndrome) to Angiosarcomas.
AU - Thomas, Louis B.
AU - Popper, Hans
AU - Berk, Paul D.
AU - Selikoff, Irving
AU - Falk, Henry
AU - Thomas, L B
AU - Popper, H
AU - Berk, P D
AU - Selikoff, I
AU - Falk, H
Y1 - 1975/01/02/
N1 - Accession Number: 83985710. Language: English. Entry Date: 20160507. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Hypersplenism -- Chemically Induced
KW - Occupational Diseases
KW - Liver Neoplasms -- Chemically Induced
KW - Vinyl Compounds -- Adverse Effects
KW - Hypertension, Portal -- Chemically Induced
KW - Sarcoma -- Chemically Induced
KW - Sarcoma -- Pathology
KW - Splenomegaly -- Pathology
KW - Hypertrophy
KW - Liver Neoplasms -- Pathology
KW - Occupational Diseases -- Pathology
KW - Spleen -- Pathology
KW - Hypertension, Portal -- Pathology
KW - Hypersplenism -- Pathology
KW - Environmental Exposure
KW - Liver Cirrhosis -- Chemically Induced
KW - Hydrocarbons, Chlorinated -- Adverse Effects
KW - Hyperplasia
KW - Biopsy
KW - Autopsy
KW - Liver Cirrhosis -- Pathology
KW - Time Factors
KW - Polyvinyls -- Adverse Effects
KW - Liver -- Pathology
SP - 17
EP - 22
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 292
IS - 1
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - Histologic examination of liver tissue (eight autopsy and 18 biopsy specimens) and five spleens from 20 workers with vinyl chloride polymerization showed hepatic angiosarcomas in 15. In addition, a peculiar pattern of progressive portal-tract, inconspicuous intralobular and conspicuous capsular fibrosis was observed in the five workers without angiosarconma, in all the seven patients with angiosarcoma from whom tumor-free portions of the liver were available, and in two tumor-free biopsies from patients subsequently found to have angiosarcoma. The fibrosis was accompanied by splenomegaly. Hypertrophy and hyperplasia of both hepatocytes and hepatic and splenic mesenchymal cells were also seen. The histologic similarity to chronic inorganic arsenical poisoning, in which angiosarcomas also occur, and to idiopathic portal hypertension (Banti's syndrome) suggests that the latter syndrome at times results from unknown toxic, possible environmental, chemicals.
SN - 0028-4793
AD - From the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, the Mount Sinai School of Medicine of the City University of New York, NY, the Section on Diseases of the Liver, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, MD, and the Cancer and Birth Defects Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, GA (address reprint requests to Dr. Thomas at the National Cancer Institute, Bldg 10, Room 2A29, Bethesda, MD 20014).
U2 - PMID: 1167315.
DO - 10.1056/NEJM197501022920104
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Thomas, L. B.;
AU - Popper, H.;
AU - Berk, P. D.;
AU - Selikoff, I.;
AU - Falk, H.;
T1 - Vinyl chloride induced liver disease
CT - Vinyl chloride induced liver disease
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1975/01/02/
VL - 292
IS - Jan 2
SP - 17
EP - 21
SN - 00284793
AD - National Cancer Institute, Bldg. 10, Rm. 2A29, Bethesda, Maryland 20014
N1 - Accession Number: 12-3331; Language: English; Chemical Name: Vinyl chloride--75-01-4; References: 32; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - Histologic examination of liver tissue (8 autopsy and 18 biopsy specimens) and 4 spleens from 20 workers with vinyl chloride polymerization showed hepatic angiosarcomas in 15. In addition, a peculiar pattern of progressive portal tract, inconspicuous intralobular and conspicuous capsular fibrosis was observed in the 5 workers without angiosarcoma, in all the 7 patients with angiosarcoma from whom tumor free portions of the liver were available, and in 2 tumor free biopsies from patients subsequently found to have angiosarcoma. The fibrosis was accompanied by splenomegaly. Hypertrophy and hyperplasia of both hepatocytes and hepatic and splenic mesenchymal cells were also seen. The histologic similarity to chronic inorganic arsenical poisoning, in which angiosarcomas also occur, and to idiopathic portal hypertension (Banti's syndrome) suggests that the latter syndrome at times results from unknown toxic, possibly environmental, chemicals.
KW - Vinyl chloride--toxicity, environmental-;
KW - Toxicity, environmental--vinyl chloride--angiosarcomas, hepatic, in humans;
KW - Polymers--vinyl chloride--angiosarcomas, hepatic, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - GALLAGHER, ROBERT E.
AU - GALLO, ROBERT C.
T1 - Type C RNA Tumor Virus Isolated from Cultured Human Acute Myelogenous Leukemia Cells.
JO - Science
JF - Science
Y1 - 1975/01/31/
VL - 187
IS - 4174
M3 - Article
SP - 350
EP - 353
SN - 00368075
AB - Previously, type C RNA tumor virus-related components have been described in blood leukocytes from patients with acute myelogenous leukemia. These components, for example, reverse transcriptase, have been shown to be most closely related to those from two oncogenic subhuman primate type C viruses (woolly monkey sarcoma virus and gibbon ape leukemia virus). Now, we report the continuous production of budding type C viruses with the same characteristic reverse transcriptase by three separate culturings of leukocytes from a single bleeding from a patient with acute myelogenous leukemia. These isolations were made possible by the discovery of a source of conditioned media which sustains exponential growth of human myelogenous leukemia cells in liquid suspension culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118459; GALLAGHER, ROBERT E. 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 1/31/1975, Vol. 187 Issue 4174, p350; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYATT, R. J.
AU - SCHWARTZ, M. A.
AU - ERDELYI, E.
AU - BARCHAS, J. D.
T1 - Dopamine β-Hydroxylase Activity in Brains of Chronic Schizophrenic Patients.
JO - Science
JF - Science
Y1 - 1975/01/31/
VL - 187
IS - 4174
M3 - Article
SP - 368
EP - 370
SN - 00368075
AB - Postmortem brain specimens from nine chronic schizophrenic patients and nine controls were assayed for activity of dopamine, 8-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine. Unlike the results of previous reports, there was no statistically significant difference in enzyme activity between the patient and control groups. There were, however, significant negative correlations between dopamine βhydroxylase activity and the time spent in the morgue before autopsy, and between enzyme activity of schizophrenics and dosage of chlorpromazine or its equivalent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118467; WYATT, R. J. 1; SCHWARTZ, M. A. 1; ERDELYI, E. 2; BARCHAS, J. D. 2; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Laboratory of Behavioral Neurochemistry, Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305; Issue Info: 1/31/1975, Vol. 187 Issue 4174, p368; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Rieder, R. O.;
AU - Rosenthal, D.;
AU - Wender, P.;
AU - Blumenthal, H.;
T1 - Offsprings of schizophrenics
CT - Offsprings of schizophrenics
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/02/01/
VL - 32
IS - Feb
SP - 200
EP - 211
AD - National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 13-1427; Language: English; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - In this report on neurological development among the offspring of schizophrenics, it was stated that genotype of the child, adverse intrauterine environment, and medication toxicity should be considered.
KW - Psychotherapeutic agents--schizophrenia--placental transfer, fetal effects, in offspring, following administration during pregnancy;
KW - Toxicity--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following maternal administration during pregnancy for schizophrenia;
KW - Placental transfer--psychotherapeutic agents--effects, fetal, in offspring, following administration during pregnancy for schizophrenia;
KW - Metabolism--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following administration during pregnancy for schizophrenia;
KW - Teratogenicity--psychotherapeutic agents--placental transfer, fetal effects, in offspring, following administration during pregnancy for schizophrenia;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
AU - Chabner, B. A.;
AU - Canellos, G. P.;
AU - Young, R. C.;
AU - DeVita, V. T.;
T1 - Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy
CT - Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1975/02/01/
VL - 35
IS - Feb
SP - 354
EP - 357
AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-5816; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Cyclophosphamide--6055-19-2 Vincristine--57-22-7 Prednisone--53-03-2 Mechlorethamine--51-75-2 Procarbazine--671-16-9; References: 12; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jimmy H. Knowles
N2 - An analysis of patterns of relapse from complete remissions of non-Hodgkin's lymphoma treated with 3 combination chemotherapy regimens is presented. Three basic treatment programs were employed. (1) A cyclical combination protocol consisted of cyclophosphamide, 400 mg/sq m/day orally for 5 days; vincristine, 1.4 mg/sq m IV on day 1; and prednisone, 100 mg/sq m/day orally for 5 days; repeated every 21 days. When a complete remission status was achieved after a minimum of 4 cycles, 2 additional consolidation cycles were administered. This regimen was used in the treatment of all patients with lymphocytic and in half the cases with mixed histiocytic-lymphocytic lymphoma. Regimens (2) and (3) were administered in 6 monthly courses and were used in the treatment of patients with histiocytic and half of the cases with mixed histiocytic-lymphocytic lymphoma. (2) MOPP consisted of nitrogen mustard (mechlorethamine), 6 mg/sq m IV on days 1 and 8; vincristine, 1.4 mg/sq m IV on days 1 and 8; procarbazine, 100 mg/sq m/day orally for 14 days; and prednisone, 40 mg/sq m/day orally for 14 days. (3) C-MOPP was a modified regimen that substituted cyclophosphamide 650 mg/sq m IV on days 1 and 8 in the place of nitrogen mustard.
KW - Cyclophosphamide--combined therapy-;
KW - Vincristine--combined therapy-;
KW - Prednisone--combined therapy-;
KW - Mechlorethamine--combined therapy-;
KW - Procarbazine--combined therapy-;
KW - Antineoplastic agents--combined therapy--lymphomas, non-Hodgkin, in patients;
KW - Combined therapy--antineoplastic agents--lymphomas, non-Hodgkin, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Catalona, W. J.
AU - Tarpley, J. L.
AU - Potvin, C.
AU - Chretien, P. B.
T1 - CORRELATIONS AMONG CUTANEOUS REACTIVITY TO DNCB, PHA-INDUCED LYMPHOCYTE BLASTO-GENESIS AND PERIPHERAL BLOOD E ROSETTES.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/02//
VL - 19
IS - 2
M3 - Article
SP - 327
EP - 333
PB - Wiley-Blackwell
SN - 00099104
AB - Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PFIA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded statistically significant positive correlations between the DNCB and PHA assays in twenty-one of twenty-eight instances, the DNCB and E rosette assays in thirteen of sixteen instances, the PHA and E rosette assays in twenty- eight of thirty-six instances, and among the DNCB, PHA and E rosette assays in ten of fourteen instances. The results suggest that both PHA-stimulated lymphocyte blastogenesis and peripheral blood E rosette-forming lymphocyte levels provide meaningful in vitro correlates of cell-mediated immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DINITROCHLOROBENZENE
KW - IMMUNE system
KW - POLY-beta-hydroxyalkanoates
KW - SKIN diseases
KW - CONTACT dermatitis
KW - BLASTOGENESIS (Embryology)
N1 - Accession Number: 15945650; Catalona, W. J. 1,2 Tarpley, J. L. 2 Potvin, C. 2,3 Chretien, P. B. 2; Affiliation: 1: Brady Research Laboratory, The John Hopkins Hospital, Baltimore, Maryland. 2: Tumor Immunology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 3: McEachren Fellow, Canadian Cancer Society.; Source Info: Feb1975, Vol. 19 Issue 2, p327; Subject Term: DINITROCHLOROBENZENE; Subject Term: IMMUNE system; Subject Term: POLY-beta-hydroxyalkanoates; Subject Term: SKIN diseases; Subject Term: CONTACT dermatitis; Subject Term: BLASTOGENESIS (Embryology); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyer, T.J.
AU - Azuma, I.
AU - Ribi, A.
T1 - Biologically Active Components from Mycobacterial Cell Walls.
JO - Immunology
JF - Immunology
Y1 - 1975/02//
VL - 28
IS - 2
M3 - Article
SP - 219
EP - 229
PB - Wiley-Blackwell
SN - 00192805
AB - The efficacy of various fractions of mycobacterial cell walls in producing experimental allergic encephalomyelitis (EAE) has been evaluated. BCG (Bacillus- Calmette-Guérin) cell walls were effective in producing EAE in all animals at dose levels as low as 40 μg. Study of subfractions of these cell walls revealed the following: (1) wax D was active, but required larger doses than BCG cell walls; (2) the chloroform-methanol-soluble (CMS) portion of wax D and P3 (a mycolic acid-trehalose ester contained therein) were inactive; (3) the chloroform-methanol- insoluble (CMI) portion of wax D was active; (4) exhaustively delipidated cell wall skeletons of BCG, Nocardia asteroides, Mycobacterium smegmatis, Corynebacterium diphtheriae and M. konsasii were active; (5) two water-soluble adjuvants prepared from mycobacteria were active. These results suggest that the mycobacterial structure responsible for EAE adjuvanticity is present in the organic solvent-insoluble cell wall skeleton framework. The activity of wax D may be due to the presence of cell-wall skeleton constituents which are found in varying quantity in most wax D preparations. Wax D components soluble in a solution of chloroforrn:methanol (diluted 2:1 v/v) do not produce EAE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGIC encephalomyelitis
KW - MYCOBACTERIA
KW - BACTERIAL cell walls
KW - BCG vaccination
KW - AUTOIMMUNE diseases
KW - GUINEA pigs
KW - IMMUNIZATION
N1 - Accession Number: 13370882; Meyer, T.J. 1 Azuma, I. 1 Ribi, A. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National lnstitutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Feb75, Vol. 28 Issue 2, p219; Subject Term: ALLERGIC encephalomyelitis; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL cell walls; Subject Term: BCG vaccination; Subject Term: AUTOIMMUNE diseases; Subject Term: GUINEA pigs; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Pennington, J. E.;
AU - Reynolds, H. Y.;
T1 - Pharmacokinetics of gentamicin in bronchial secretions
CT - Pharmacokinetics of gentamicin in bronchial secretions
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1975/02/01/
VL - 131
IS - Feb
SP - 158
EP - 161
SN - 00221899
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Building 10, Room 11B-13, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-5653; Language: English; Chemical Name: Gentamicin--1403-66-3; References: 26; Journal Coden: JIDIAQ; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Robert Barger
N2 - The rate of appearance, peak concentrations, and rate of clearance of gentamicin in bronchial secretions of dogs was studied by using rapid IV infusion and IM injection. A 10 min infusion of 1.7 mg/kg or 2 divided doses of 0.85 mg/kg each in 4 hr were given to dogs with simultaneous blood and bronchial specimens collected at specific intervals after administration. IV infusion produced levels of greater than 3meq/ml in bronchial secretions for approximately 100 min but the drug was cleared from respiratory secretions within 3 hr. IM injection gave low but more sustained bronchial levels. The minimum inhibitory concentration of gentamicin needed should be considered when the dose or frequency of parenteral gentamicin is ordered.
KW - Gentamicin--pharmacokinetics-;
KW - Pharmacokinetics--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW - Drugs, body distribution--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW - Metabolism--gentamicin--intramuscular, and IV, bronchial secretion levels, in dogs;
KW - Drug administration--routes--gentamicin, IM and IV, bronchial secretion levels, in dogs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hearing, Vincent J.
AU - Ekel, Thomas M.
T1 - INVOLVEMENT OF TYROSINASE IN MELANIN FORMATION IN MURINE MELANOMA.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/02//
VL - 64
IS - 2
M3 - Article
SP - 80
EP - 85
SN - 0022202X
AB - The possibility that peroxidase is functional in melanogenesis in the murine S-91 melanoma has been investigated. It was found that, as in the normal mouse, tyrosinase is the enzyme responsible for the bulk of melanin formation in the malignant melanocyte. Tyrosinase was capable of utilizing tyrosine as a substrate, as well as dopa, although the Vmax with dopa was much higher than with tyrosine. Conversely, the affinity of the enzyme for tyrosine is higher than for dopa, and this relationship may in part be responsible for the occasional misinterpretation of the functional capability of this enzyme. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANOGENESIS
KW - TYROSINE
KW - MELANOMA
KW - ENZYMES
KW - DOPA
KW - CANCER
N1 - Accession Number: 12510302; Hearing, Vincent J. 1 Ekel, Thomas M. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland.; Source Info: Feb75, Vol. 64 Issue 2, p80; Subject Term: MELANOGENESIS; Subject Term: TYROSINE; Subject Term: MELANOMA; Subject Term: ENZYMES; Subject Term: DOPA; Subject Term: CANCER; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510302
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levis, William R.
AU - Whalen, John J.
AU - Powell, John A.
T1 - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/02//
VL - 64
IS - 2
M3 - Article
SP - 100
EP - 104
SN - 0022202X
AB - Dinitrochlorobenzene (DNCB) coupled to peripheral blood erythrocytes or leukocytes forms a particulate complex, DNCB-antigen. The addition of DNCB-antigen induced blastogenesis and DNA synthesis in leukocyte cultures from DNCB-sensitized human subjects and not in leukocyte cultures from nonsensitized controls. In general, sensitized subjects who displayed a higher degree of cutaneous reactivity to DNCB, as manifested by duration and intensity of dermatitis, also showed a greater blastogenic response to DNCB-antigen in vitro. This quantitative correlation, however, was not invariant. Certain soluble factor(s), or lymphokines are released following the addition of DNCB-antigen to leukocyte cultures prepared from some sensitive subjects who were rechallenged one or more times with DNCB. These lymphokines induce blastogenesis in secondary target leukocyte populations from nonsensitized subjects. Extended studies are presented which show little or no lymphokine activity in peripheral blood leukocyte cultures during a primary immune response, despite high degrees of blastogenic activity in response to DNCB-antigen. Significant lymphokine activity was observed only following additional rechallenge with DNCB. Blastogenesis and skin reactivity specific for DNCB have been shown to develop at about the same time during a primary immune response. This, along with the quantitative correlation shown in this communication, suggests that both processes probably reflect thymic-dependent cellular immunity. The appearance of lymphokine activity following rechallenge with DNCB suggests that DNCB-induced lymphokines may represent an amplifying mechanism of the cellular immune response that involves recruitment of previously uncommitted lymphocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DINITROCHLOROBENZENE
KW - ERYTHROCYTES
KW - LEUCOCYTES
KW - DNA synthesis
KW - ANTIGENS
KW - BLASTOGENESIS (Embryology)
N1 - Accession Number: 12510316; Levis, William R. 1 Whalen, John J. 1 Powell, John A. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Feb75, Vol. 64 Issue 2, p100; Subject Term: DINITROCHLOROBENZENE; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: DNA synthesis; Subject Term: ANTIGENS; Subject Term: BLASTOGENESIS (Embryology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510316
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Khan, A. H.;
AU - Driscoll, J. S.;
T1 - Active antitumor components in a decomposed amino sugar. 1. Effect of sugar structure on activity
CT - Active antitumor components in a decomposed amino sugar. 1. Effect of sugar structure on activity
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/02/01/
VL - 64
IS - Feb
SP - 295
EP - 299
SN - 00223549
AD - Drug Development Branch, Drug Research and Development, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-0507; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents aminoribose; References: 12; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Pharmacology; Abstract Author: D. R. Tousignaut
N2 - A number of aminoribose derivatives were prepared and tested against the murine L-1210 and P-388 leukemia and the B-16 melanoma tumor systems. Both the \b/-haloethyl group and a secondary amine were required for highest activity.
KW - Aminoribose--derivatives-;
KW - Sugars--aminoribose--derivatives, structure-activity relationships, in vitro antitumor effects;
KW - Antineoplastic agents--aminoribose--derivatives, structure-activity relationships, in vitro effects;
KW - Structure-activity relationships--aminoribose--derivatives, in vitro antitumor effects;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Canellos, G. P.;
AU - Chabner, B.;
AU - Schein, P.;
AU - Hubbard, S. P.;
AU - \ET/;
T1 - Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy
CT - Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1975/02/01/
VL - 1
IS - Feb 1
SP - 248
EP - 250
SN - 00237507
AD - Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-3663; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Cyclophosphamide--6055-19-2 Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide, mechlorethamine, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents mechlorethamine, cyclophosphamide, prednisone, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents prednisone, cyclophosphamide, mechlorethamine, procarbazine and vincristine (10:00); AHFS Class: Antineoplastic agents procarbazine, cyclophosphamide, mechlorethamine, prednisone and vincristine (10:00); AHFS Class: Antineoplastic agents vincristine, cyclophosphamide, mechlorethamine, prednisone and procarbazine; References: 18; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Twenty-seven patients with advanced diffuse histiocytic lymphoma (reticulum-cell sarcoma) were treated with combination chemotherapy utilizing nitrogen mustard (mechlorethamine) (or cyclophosphamide), procarbazine, vincristine, and prednisone. The MOPP regimen consisted of six 2-week cycles of nitrogen mustard (6 mg/sqm), vincristine (1.4 mg/sqm) on days 1 and 8 of each cycle, procarbazine (100 mg/sqm) per day orally for the first 14 days of each cycle and prednisone (40 mg/sqm) orally on days 1-14 on the first and fourth cycle of treatment. In the C-MOPP variation, cyclophosphamide at a dose of 650 mg/sqm on days 1 and 8 was used interchangeably with nitrogen mustard. Each 14-day cycle was separated by a 2-week rest period. Subsequent cycles were reinstituted on the 28th day from initiation of the previous cycle using a sliding scale for reduction of doses if the white blood cell and platelet counts had not returned entirely to normal. Eleven (41%) achieved a complete remission and only one of these has had a recurrence of tumor. The remaining 10 complete responders were free of all evidence of tumor when last seen 26-105 months from the end of treatment. In contrast, all nonresponders or partial responders have died. An interpretation of published survival data suggests that this virulent disease evolves quickly and is usually rapidly fatal if treatment is unsuccessful. Survival free of disease beyond 2 years from the end of treatment may be considered tantamount to cure. This definition of cure, previously applied only to patients treated with radiotherapy, seems applicable to patients who achieve complete remissions with modern drug treatment.
KW - Cyclophosphamide--mechlorethamine, prednisone, procarbazine and vincristine-;
KW - Mechlorethamine--cyclophosphamide, prednisone, procarbazine and vincristine-;
KW - Prednisone--cyclophosphamide, mechlorethamine, procarbazine and vincristine-;
KW - Procarbazine--cyclophosphamide, mechlorethamine, prednisone and vincristine-;
KW - Vincristine--cyclophosphamide, mechlorethamine, prednisone and procarbazine-;
KW - Antineoplastic agents--cyclophosphamide, mechlorethamine, prednisone, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW - Antineoplastic agents--mechlorethamine, cyclophosphamide, prednisone, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW - Antineoplastic agents--prednisone, cyclophosphamide, mechlorethamine, procarbazine and vincristine--lymphomas, histiocytic, in patients;
KW - Antineoplastic agents--procarbazine, cyclophosphamide, mechlorethamine, prednisone and vincristine--lymphomas, histiocytic, in patients;
KW - Antineoplastic agents--vincristine, cyclophosphamide, mechlorethamine, prednisone and procarbazine--lymphomas, histiocytic, in patients;
KW - Combined therapy--antineoplastic agents--lymphomas, histiocytic, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Weiss, George H.
T1 - Letter to the Editor.
JO - Transportation Science
JF - Transportation Science
Y1 - 1975/02//
VL - 9
IS - 1
M3 - Letter
SP - 86
PB - INFORMS: Institute for Operations Research
SN - 00411655
AB - Presents a letter to the editor regarding solution to an integral equation in the study of semi-poisson headway distribution.
KW - INTEGRAL equations
KW - LETTERS to the editor
KW - POISSON distribution
N1 - Accession Number: 5848322; Weiss, George H. 1; Affiliation: 1: National Institutes of Health, Bethesda, Maryland; Source Info: Feb75, Vol. 9 Issue 1, p86; Subject Term: INTEGRAL equations; Subject Term: LETTERS to the editor; Subject Term: POISSON distribution; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - PIEZ, KARL A.
T1 - NIH Management.
JO - Science
JF - Science
Y1 - 1975/02/14/
VL - 187
IS - 4176
M3 - Article
SP - 497
EP - 497
SN - 00368075
N1 - Accession Number: 85118503; PIEZ, KARL A. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/14/1975, Vol. 187 Issue 4176, p497; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Jacobs, S. A.;
AU - Bleyer, W. A.;
AU - Chabner, B. A.;
AU - Johnson, D. G.;
T1 - Altered plasma pharmacokinetics of methotrexate administered intrathecally
CT - Altered plasma pharmacokinetics of methotrexate administered intrathecally
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1975/02/22/
VL - 1
IS - Feb 22
SP - 465
EP - 466
SN - 00237507
AD - Laboratory of Chemical Pharmacology and Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-3664; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 6; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology; Abstract Author: Joan Lentine
N2 - A pilot pharmacokinetic study in 2 patients with lymphocytic leukemia showed that methotrexate, when administered intrathecally acts as a depot or slow release form of the drug. Plasma concentrations remain at a pharmacologically significant level more than twice as long after an intrathecal dose as after an oral or IV dose.
KW - Methotrexate--pharmacokinetics-;
KW - Pharmacokinetics--methotrexate--sustained-action, following intrathecal administration, in patients;
KW - Antineoplastic agents--methotrexate--pharmacokinetics, sustained-action, following intrathecal administration, in patients;
KW - Sustained-action medications--methotrexate--pharmacokinetics, following intrathecal administration, in patients;
KW - Drug administration--routes--methotrexate, sustained-action, following intrathecal administration, in patients;
KW - Blood levels--methotrexate--sustained-action, following intrathecal administration, in patients;
KW - Metabolism--methotrexate--sustained-action, following intrathecal administration, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - DVORAK, JAMES A.
AU - MILLER, LOUIS H.
AU - WHITEHOUSE, WILLARD C.
AU - SHIROISHI, TSUGIYE
T1 - Invasion of Erythrocytes by Malaria Merozoites.
JO - Science
JF - Science
Y1 - 1975/02/28/
VL - 187
IS - 4178
M3 - Article
SP - 748
EP - 750
SN - 00368075
AB - An electro-optical system was developed to record microscope images with high resolution at low light intensities. The system was used to study the invasion of erythrocytes by malaria merozoites. Invasion consists of attachment of the anterior end of the parasite to the erythrocyte, deformation of the erythrocyte, and entry of the parasite by erythrocyte membrane invagination. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118603; DVORAK, JAMES A. 1,2; MILLER, LOUIS H. 1,2; WHITEHOUSE, WILLARD C. 3; SHIROISHI, TSUGIYE 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases; 2: National Institutes of Health, Bethesda, Maryland 20014; 3: Television Engineering Section, Clinical Center, National Institutes of Health; Issue Info: 2/28/1975, Vol. 187 Issue 4178, p748; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Post, R. M.;
T1 - Cocaine psychoses: a continuum model
CT - Cocaine psychoses: a continuum model
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1975/03/01/
VL - 132
IS - Mar
SP - 225
EP - 231
SN - 0002953X
AD - 3-West Clinical Research Unit, Section of Psychobiology, Adult Psychiatric Branch, Building 10, Room 3S239, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 12-6539; Language: English; Chemical Name: Cocaine--50-36-2; References: 67; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: C. Robert Sturwold
N2 - Clinical aspects of cocaine euphoria, disphoria, and paranoid psychosis are reviewed. Increasing the dose and/or the chronicity of cocaine administration is associated with increasingly severe affective and cognitive alterations. Personality and experimental-genetic predispositions are crucial factors in determining the patient's response to cocaine. Pre-existing active psychopathologies including schizophrenia, mania, and depression are shown to alter the proposed progression of cocaine-induced symptomatology. The cocaine syndromes mirror many aspects of the endogenous psychoses closely enough to warrant comparison, the model derived from such study may be useful in conceptualizing biochemical-behavioral interactions.
KW - Cocaine--toxicity-;
KW - Toxicity--cocaine--behavioral, review, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zahn, T. P.;
AU - Abate, F.;
AU - Little, B. C.;
AU - Wender, P. H.;
T1 - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
CT - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/03/01/
VL - 32
IS - Mar
SP - 381
EP - 387
AD - National Institutes of Health, Bldg 10, Rm 2N-262, Bethesda, Maryland 20014
AD - Unit on Psychophysiology, National Institute of Mental Health, Public Health Service, Dept. of H. E. W. Bethesda, Maryland
N1 - Accession Number: 13-1114; Language: English; Trade Name: Ritalin; Generic Name: Methylphenidate; Chemical Name: Methylphenidate--113-45-1 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants methylphenidate (28:20); AHFS Class: Central nervous system stimulants dextroamphetamine; References: 26; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Minimally brain dysfunctioned children on methylphenidate HC1 (Ritalin) or dextroamphetamine sulfate had increased skin conductance and heart rate and decreased skin temperatiure and reaction time when compared to baseline values obtained from normal and minimally brain dysfunctioned children not taking drugs. In the study of 54 normal and 42 minimally brain dysfunctioned children, autonomic base levels and responsivity to stimuli were investigated. The minimally brain dysfunctioned children were less reactive, autonomically, to all types of stimuli.
KW - Methylphenidate--effects-;
KW - Dextroamphetamine--effects-;
KW - Hyperkinesis--methylphenidate--effects, autonomic, in children;
KW - Hyperkinesis--dextroamphetamine--effects, autonomic, in children;
KW - Central nervous system stimulants--methylphenidate--effects, autonomic, in minimal brain dysfunction children;
KW - Central nervous system stimulants--dextroamphetamine--effects, autonomic, in minimal brain dysfunction children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Watanabe, H.;
AU - Passonneau, J. V.;
T1 - Cyclic adenosine monophosphate in cerebral cortex
CT - Cyclic adenosine monophosphate in cerebral cortex
JO - Arch. Neurol. (Chicago)
JF - Arch. Neurol. (Chicago)
Y1 - 1975/03/01/
VL - 32
IS - Mar
SP - 181
EP - 184
AD - Dept. of Neurosurgery, Juntendo Univ., Tokyo, Japan
AD - Reprints: Section on Cellular Neurochemistry, Laboratory of Neuropathology and Neurochemistry Sciences, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bldg. 36, Rm. 4D-16, Bethesda, Maryland 20014
N1 - Accession Number: 13-0775; Language: English; Chemical Name: Theophylline--5967-84-0 Chlorpromazine--50-53-3 Trifluoperazine--117-89-5 Diphenhydramine--58-73-1 Reserpine--50-55-5; Therapeutic Class: (12:08.08); AHFS Class: Spasmolytics theophylline (28:16.08); AHFS Class: Tranquilizers chlorpromazine (28:16.08); AHFS Class: Tranquilizers trifluoperazine (4:00); AHFS Class: Antihistamines diphenhydramine (24:08); AHFS Class: Hypotensive agents dichloroisoproterenol (12:16); AHFS Class: Sympatholytic agents pronethalol (24:08); AHFS Class: Hypotensive agents reserpine; References: 32; Journal Coden: ARNEAS; Section Heading: Pharmacology
N2 - Stab-wound injury produced a 7-fold elevation in cyclic adenosine monophosphate (AMP) in mouse brain within one minute; the increase in cyclic AMP in the brain was blocked by prior treatment of the animal by theophylline, chlorpromazine, trifluoperazine HCl, and diphenhydramine HCl. Neither dichloroisoproterenol, pronethalol, nor reserpine blocked the rise in cyclic AMP concentration due to injury. The results following administration of drugs suggest that the increases in cyclic AMP due to injury may be mediated by adenosine. Theophylline and phenothiazine derivatives have been shown previously to decrease adenosine-mediated increases in cyclic AMP in brain slices. The absence of any effect after administration of dichloroisoproterenol or pronethalol suggests that the increase in cyclic AMP after injury is not through catecholamine release. Hypothermia reduced the increase in cyclic AMP in injured brain after one minute.
KW - Theophylline--effects-;
KW - Chlorpromazine--effects-;
KW - Trifluoperazine--effects-;
KW - Diphenhydramine--effects-;
KW - Dichloroisoproterenol--effects-;
KW - Pronethalol--effects-;
KW - Reserpine--effects-;
KW - Spasmolytics--theophylline--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Tranquilizers--chlorpromazine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Tranquilizers--trifluoperazine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Antihistamines--diphenhydramine--effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Hypotensive agents--dichloroisoproterenol--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Sympatholytic agents--pronethalol--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
KW - Hypotensive agents--reserpine--lack, effects, on rise in cyclic AMP due to injury, in mouse brain;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Albright, L.;
AU - Madigan, J.;
AU - Gaston, M.;
AU - Houchens, D.;
T1 - Therapy in an intracerebral murine glioma model, using bacillus calmette-guerin, neuraminidase-treated tumor cells, and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea
CT - Therapy in an intracerebral murine glioma model, using bacillus calmette-guerin, neuraminidase-treated tumor cells, and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/03/01/
VL - 35
IS - Mar
SP - 658
EP - 665
SN - 00085472
AD - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 12-6596; Language: English; Trade Name: 1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosourea; Generic Name: Lomustine; Chemical Name: Lomustine--13010-47-4; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents BCG vaccines (10:00); AHFS Class: Antineoplastic agents lomustine; References: 27; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing; Pharmacology
N2 - In vivo therapy studies revealed significant increased survival of animals injected with GL-26 murine glioma who were preimmunized with V. cholerae neuraminidase and mitomycin C-treated cells plus complete Freund's adjuvant. 1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosourea (lomustine: I), when given IP on day 3 or 12 after tumor challenge, also resulted in significant increases in survival. Furthermore, the effects of I and preimmunization were additive, with significant additional protection occurring in animals that had received preimmunization as well as I. In contrast to results reported for several extracranial tumor systems, immunotherapy, using either V. cholerae neuraminidase and mitomycin-treated tumor cells, Bacillus Calmette-Guerin, or both beginning 3 or 4 days after tumor challenge, did not produce any significant increases in survival.
KW - BCG vaccines--effects-;
KW - Lomustine--effects-;
KW - Immunosuppressive agents--BCG vaccines--effects, survival, in animals treated with GL-26 murine glioma;
KW - Antineoplastic agents--lomustine--effects, survival, in animals treated with GL-26 murine glioma;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Anderson, T.;
AU - McMenamin, M. G.;
AU - Schein, P. S.;
T1 - Chlorozotocin, 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose, an antitumor agent with modified bone marrow toxicity
CT - Chlorozotocin, 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose, an antitumor agent with modified bone marrow toxicity
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/03/01/
VL - 35
IS - Mar
SP - 761
EP - 765
SN - 00085472
AD - Clinical Pharmacology Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-5911; Language: English; Trade Name: 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose; Generic Name: Chlorozotocin; Chemical Name: Chlorozotocin--54749-90-5; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents chlorozotocin; References: 9; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2 - A 701% and a 401% increase in life-span were attained with chlorozotocin, 15-20 mg/kg IP, in mice treated on day 2 or day 6 of L1210 leukemia tumor growth, respectively. Sixty percent of day 2-treated mice and 30% of day 6-treated mice survived for 90 days. At the maximally effective dose against L1210, chlorozotocin produced no significant depression in normal bone marrow DNA synthesis nor in peripheral neutrophil count, in contrast to a sustained \GT/ 90% inhibition in L1210 ascites cell DNA synthesis. If the antitumor activity and reduced bone marrow toxicity of chlorozotocin are confirmed in man, the use of this compound would facilitate treatment of patients with neoplastic disease who have preexisting abnormal bone marrow function or would allow for the more effective use of a nitrosourea agent in combination with anticancer agents possessing more potent myelosuppressive properties.
KW - Chlorozotocin--leukemias-;
KW - Antineoplastic agents--chlorozotocin--leukemias, therapy, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Waldrop, Mary F.
AU - Halverson Jr., Charles F.
T1 - Intensive and Extensive Peer Behavior: Longitudinal and Cross-sectional Analyses.
JO - Child Development
JF - Child Development
Y1 - 1975/03//
VL - 46
IS - 1
M3 - Article
SP - 19
EP - 26
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12189684; Waldrop, Mary F. 1 Halverson Jr., Charles F. 1; Affiliation: 1: Child Research Branch, National Institute of Mental Health; Source Info: Mar1975, Vol. 46 Issue 1, p19; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1467-8624.ep12189684
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189684&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campbell, John D.
T1 - Illness Is a Point of View: The Development of Children's Concepts of Illness.
JO - Child Development
JF - Child Development
Y1 - 1975/03//
VL - 46
IS - 1
M3 - Article
SP - 92
EP - 100
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12189728; Campbell, John D. 1; Affiliation: 1: National Institute of Mental Health; Source Info: Mar1975, Vol. 46 Issue 1, p92; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1467-8624.ep12189728
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189728&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Griffith, J. D.;
AU - Carr, C. B.;
T1 - Etorphine in man. 1. Subjective effects and suppression of morphine abstinence
CT - Etorphine in man. 1. Subjective effects and suppression of morphine abstinence
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1975/03/01/
VL - 17
IS - Mar
SP - 267
EP - 272
SN - 00099236
AD - National Institute on Drug Abuse, Addiction Research Center, Lexington, Kentucky
N1 - Accession Number: 12-6401; Language: English; Chemical Name: Etorphine--14521-96-1 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, etorphine (28:08); AHFS Class: Analgesics and antipyretics etorphine, comparison, morphine; References: 10; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2 - The effects of etorphine (I) were qualitatively and quantitatively compared to those of morphine. In 12 nondependent subjects, I in doses of 0.025, 0.050, and 0.100 mg produced pupillary constriction and morphine-like subjective effects and euphoria. I was 500 times as potent as morphine, with a very rapid onset and short duration of action. In 4 morphine-dependent subjects, I suppressed abstinence but for a shorter period than morphine. These studies indicate than in man I is a morphine-like drug with a high abuse potential.
KW - Etorphine--comparison, morphine-;
KW - Morphine--comparison, etorphine-;
KW - Dependence--etorphine, comparison, morphine--effects, dosage, in patients;
KW - Dosage--etorphine, comparison, morphine--effects, in patients;
KW - Dependence--morphine, comparison, etorphine--effects, dosage, in patients;
KW - Dosage--morphine, comparison, etorphine--effects, and dependence, in patients;
KW - Analgesics and antipyretics--morphine, comparison, etorphine--dosage, and dependent effects, in patients;
KW - Analgesics and antipyretics--etorphine, comparison, morphine--dosage, and dependent effects, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gorodetzky, C. W.;
AU - Kullberg, M. P.;
T1 - Etorphine in man. 2. Detectability in urine by common screening methods
CT - Etorphine in man. 2. Detectability in urine by common screening methods
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1975/03/01/
VL - 17
IS - Mar
SP - 273
EP - 276
SN - 00099236
AD - National Institute on Drug Abuse, Addiction Research Center, and Univ. of Kentucky College of Medicine, Dept. of Psychiatry, Lexington, Kentucky
N1 - Accession Number: 12-5782; Language: English; Chemical Name: Etorphine--14521-96-1; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics etorphine; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Investigational Drugs; Drug Analysis
N2 - A single highly euphorogenic dose of etorphine (I), 100 mcg, was administered SC to 7 nontolerant subjects, and all urine samples were collected for one day prior to and 3 days following drug administration. Samples were analyzed for the presence of opiates by radioimmunoassay (Abuscreen) and homogeneous enzyme immunoassay (EMIT), with cutoffs for positives of 40 and 500 mg/ml, respectively. Samples were analyzed for I by thin layer chromatography (TLC) with iodoplatinate preceded by XAD-2 resin extraction (sensitivity = 0.2 mcg/ml of urine) and by gas-liquid chromatography (GLC) preceded by organic solvent extraction and trimethylsilyl derivatization (sensitivity = 0.1 mcg I/ml of urine). The last pre-drug and first two post-drug samples were also analyzed after acid hydrolysis by TLC and after glucuronidase hydrolysis by TLC and GLC. No sample gave a positive opiate result in either immunoassay, and no I was detected in the TLC and GLC analyses of any urine sample. Thus, it is unlikely that the abuse of I could be diagnosed by urinalysis using the common screening methods of radioimmunoassay, EMIT, TLC preceded by XAD-2 resin extraction, or GLC preceded by organic solvent extraction and trimethylsilyl derivatization.
KW - Etorphine--excretion-;
KW - Excretion--etorphine--urinary, lack, GLC and TLC detection, in humans;
KW - Metabolism--etorphine--excretion, urinary, lack, GLC and TLC detection, in humans;
KW - Dependence--etorphine--excretion, urinary, lack, GLC and TLC detection, in humans;
KW - Chromatography, thin layer--etorphine--urine, detection, lack, in humans;
KW - Chromatography, gas--etorphine--urine, detection, lack, in humans;
KW - Analgesics and antipyretics--morphine--excretion, detection in urine, lack, GLC and TLC;
KW - Analgesics and antipyretics--etorphine--excretion, detection in urine, lack, GLC and TLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Andres, Reubin
T1 - Defining and evaluating the myriad influences on human aging.
JO - Geriatrics
JF - Geriatrics
Y1 - 1975/03//
VL - 30
IS - 3
M3 - Article
SP - 36
EP - 40
SN - 0016867X
N1 - Accession Number: 18945341; Andres, Reubin 1; Source Information: Mar1975, Vol. 30 Issue 3, p36; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1435
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Balow, J.;
AU - Hurley, D. L.;
AU - Fauci, A. S.;
T1 - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
CT - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
JO - J. Immunol.
JF - J. Immunol.
Y1 - 1975/03/01/
VL - 114
IS - Mar
SP - 1072
EP - 1076
AD - National Institute of Allergy and Infectious Diseases, N1H, Bethesda, Maryland 20014
N1 - Accession Number: 12-6541; Language: English; Chemical Name: Hydrocortisone--50-23-7 Cortisone--53-06-5; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone (68:04); AHFS Class: Steroids, cortico- cortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2 - The effects of acute vs chronic glucocorticosteroid administration on established cellular immune responses were studied in guinea pigs previously sensitized to tuberculin. A greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone (I) and 24 hr after daily SC injections of depot cortisone acetate (II). After a single dose of I, peripheral lymphocyte migration inhibitory factor production and antigen and mitogen-induced proliferation were unchanged. However, the peripheral lymphocytes remaining in the circulation after chronic II treatment showed a marked decrease in both antigen-induced migration inhibitory factor and proliferation, although mitogen responses remained normal. Although similar levels of lymphocytopenia were induced by acute and chronic glucocorticosteroid administration, only chronic treatment was associated with depression of certain cell-mediated lymphocyte functions. The available evidence suggests that these changes may depend on glucocorticosteroid-induced selective alterations in the circulation patterns of certain subpopulations of lymphocytes.
KW - Hydrocortisone--dosage schedules-;
KW - Cortisone--dosage schedules-;
KW - Dosage schedules--cortisone--chronic, comparison, acute, effects on cellular immune response, in guinea pigs;
KW - Dosage schedules--hydrocortisone--chronic, comparison, acute, effects on cellular immune response, in guinea pigs;
KW - Steroids, cortico---hydrocortisone--dosage schedules, chronic and acute, effects on cellular immune response, in guinea pigs;
KW - Steroids, cortico---cortisone--dosage schedules, chronic and acute, effects on cellular immune response, in guinea pigs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Barlow, J. E.;
AU - Hurley, D. L.;
AU - Fauci, A. S.;
T1 - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
CT - Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity
JO - J. Immunol.
JF - J. Immunol.
Y1 - 1975/03/01/
VL - 114
IS - Mar
SP - 1072
EP - 1076
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-0144; Language: English; Chemical Name: Hydrocortisone--50-23-7 Cortisone--53-06-5; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- hydrocortisone (68:04); AHFS Class: Steroids, cortico- cortisone; References: 17; Journal Coden: JOIMA3; Section Heading: Pharmacology
N2 - The effects of acute and chronic glucocorticosteroid administration on established cellular immune responses were compared in guinea pigs previously sensitized to tuberculin. A greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone and 24 hr after daily SC injections of depot cortisone acetate. After a single dose of hydrocortisone, peripheral lymphocyte migration inhibitory factor production and antigen and mitogen-induced proliferation were unchanged. However, the peripheral lymphocytes remaining in the circulation after chronic cortisone treatment showed a marked decrease in both antigen-induced migration inhibitory factor and proliferation, although mitogen responses remained normal. Although similar levels of lymphocytopenia were induced by acute and chronic treatment, only chronic treatment was associated with depression of certain cell-mediated lymphocyte functions. The available evidence suggests that these changes may depend on glucocorticosteroid-induced selective alterations in the circulation patterns of certain subpopulations of lymphocytes.
KW - Hydrocortisone--effects-;
KW - Cortisone--effects-;
KW - Steroids, cortico---hydrocortisone--effects, immune response, in tuberculin sensitive guinea pigs;
KW - Steroids, cortico---cortisone--effects, on immune response, in tuberculin sensitive guinea pigs;
KW - Immunology--cortisone--effects, in tuberculin sensitive guinea pigs;
KW - Immunology--hydrocortisone--effects, in tuberculin sensitive guinea pigs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Robbins, Jay H.
AU - Kraemer, Kenneth H.
AU - Flaxman, B. Allen
T1 - DNA REPAIR IN TUMOR CELLS FROM THE VARIANT FORM OF XERODERMA PIGMENTOSUM.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/03//
VL - 64
IS - 3
M3 - Article
SP - 150
EP - 155
SN - 0022202X
AB - Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing ultraviolet (UV) light-induced damage to their DNA, for they have a reduced rate of UV-induced thymidine incorporation. XP variants, however, have clinical manifestations of XP, but all their tissues tested to date have a normal rate of UV-induced 3H-thymidine incorporation. We have now tested tumor cells from an XP variant and from a typical XP patient. The variant's tumor cells, in contrast to those of the typical patient, had no detectable defect in their UV-induced thymidine incorporation. We conclude, therefore, that the cells that formed tumors in this XP variant resemble his other cells in DNA repair capacity, and do not represent a minor cell population with the kind of DNA repair defect that is reflected in reduced UV-induced thymidine incorporation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA repair
KW - XERODERMA pigmentosum
KW - PRECANCEROUS conditions
KW - CANCER cells
KW - ULTRAVIOLET radiation
KW - THYMIDINE
N1 - Accession Number: 12533310; Robbins, Jay H. 1,2 Kraemer, Kenneth H. 1,2 Flaxman, B. Allen 1,2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2: Skin and Cancer Hospital of Philadelphia, Department of Dermatology, Temple University Health Sciences Center, Philadelphia, Pennsylvania.; Source Info: Mar1975, Vol. 64 Issue 3, p150; Subject Term: DNA repair; Subject Term: XERODERMA pigmentosum; Subject Term: PRECANCEROUS conditions; Subject Term: CANCER cells; Subject Term: ULTRAVIOLET radiation; Subject Term: THYMIDINE; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12533310
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wiebel, F. J.
AU - Leutz, J. C.
AU - Gelboin, H. V.
T1 - ARYL HYDROCARBON (BENZO[A]PYRENE) HYDROXYLASE: A MIXED-FUNCTION OXYGENASE IN MOUSE SKIN.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/03//
VL - 64
IS - 3
M3 - Article
SP - 184
EP - 189
SN - 0022202X
AB - Mouse skin contains awl hydrocarbon (benzo[a]pyrene) hydroxylase activity which is inducible by aromatic polycyclic hydrocarbons and benzoflavones. The duration and magnitude of induction, but not the initial kinetics, are dependent on the inducer dose. The cutaneous hydroxylase activity is inhibited by carbon monoxide and requires the presence of NADPH, indicating that the enzyme is one of the mixed-function oxygenases. The highest enzyme activity was found in the superficial layer of skin which contains the sebaceous glands and the upper pilary canals. Enzyme activities were intermediate in the epidermis and lowest in the deeper dermal layers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROCARBONS
KW - EPITHELIUM
KW - SKIN
KW - CARBON monoxide
KW - OXYGENASES
KW - ENZYMES
KW - ENZYME kinetics
N1 - Accession Number: 12533351; Wiebel, F. J. 1 Leutz, J. C. 1 Gelboin, H. V. 1; Affiliation: 1: Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1975, Vol. 64 Issue 3, p184; Subject Term: HYDROCARBONS; Subject Term: EPITHELIUM; Subject Term: SKIN; Subject Term: CARBON monoxide; Subject Term: OXYGENASES; Subject Term: ENZYMES; Subject Term: ENZYME kinetics; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12533351
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linsky, Arnold S.
T1 - STIMULATING RESPONSES TO MAILED QUESTIONNAIRES: A REVIEW.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1975///Spring75
VL - 39
IS - 1
M3 - Article
SP - 82
PB - Oxford University Press / USA
SN - 0033362X
AB - This study collates findings from the available research literature of sociology, psychology, business, and education on techniques to increase responses to mailed questionnaires. Among the techniques reviewed here are those that employ mechanical or perceptual means to facilitate responses, those that use broad motivational factors to build on social and personal values of the respondent, and those that offer direct rewards for return of questionnaires. It is concluded that a change in over-all research strategy may be necessary to increase our ability to ensure high mail-questionnaire returns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Questionnaires
KW - Sociology
KW - Psychology
KW - Business
KW - Education
KW - Mail surveys
N1 - Accession Number: 5412934; Linsky, Arnold S. 1,2; Affiliations: 1: Associate Professor, Department of Sociology and Anthropology, University of New Hampshire.; 2: Research Director for the National Institute of Mental Health Training Project, "Family, Community Agencies, and Behavior Problems," University of New Hampshire.; Issue Info: Spring75, Vol. 39 Issue 1, p82; Thesaurus Term: Questionnaires; Thesaurus Term: Sociology; Thesaurus Term: Psychology; Thesaurus Term: Business; Thesaurus Term: Education; Subject Term: Mail surveys; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 20p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - GEN
AU - Weissman, Harold
AU - Smith, Neilson F.
AU - Pappenfort, Donnell M.
AU - Taylor, Delores A.
AU - Causemaker, Carole J.
AU - Chapla, Lee S.
AU - Dalrymple, Irene Grant
T1 - letters.
JO - Social Work
JF - Social Work
Y1 - 1975/03//
VL - 20
IS - 2
M3 - Letter
SP - 171
EP - 172
PB - Oxford University Press / USA
SN - 00378046
AB - Presents several letters to the editor. Response of a reader on comments made by scholar Donald Vorwaller on the book "Overcoming Mismanagement in the Human Service Professions "; Feedback of a reader on a collection of commissioned papers "Child Caring: Social Policy and the institution"; Comments of a reader on the article "A Study of Homosexual Women."
KW - LETTERS to the editor
KW - PUBLIC welfare
KW - HUMAN services
KW - SOCIAL marketing
KW - WELFARE economics
KW - SOCIAL policy
N1 - Accession Number: 5267416; Weissman, Harold 1 Smith, Neilson F. 2 Pappenfort, Donnell M. 3 Taylor, Delores A. 4 Causemaker, Carole J. Chapla, Lee S. 5 Dalrymple, Irene Grant; Affiliation: 1: Hunter College School of Social Work, New York, New York. 2: Division of Manpower and Training Programs, National Institute of Mental Health, Rockville, Maryland. 3: School of Social Service Administration, University of Chicago, Chicago, Illinois. 4: Child and Family Services of Connecticut, Hartford, Connecticut. 5: Norristown State Hospital, Norristown, Pennsylvania.; Source Info: Mar75, Vol. 20 Issue 2, p171; Subject Term: LETTERS to the editor; Subject Term: PUBLIC welfare; Subject Term: HUMAN services; Subject Term: SOCIAL marketing; Subject Term: WELFARE economics; Subject Term: SOCIAL policy; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - STONE, T. W.
AU - TAYLOR, D. A.
AU - BLOOM, F. F.
T1 - Cyclic AMP and Cyclic GMP May Mediate Opposite Neuronal Responses in the Rat Cerebral Cortex.
JO - Science
JF - Science
Y1 - 1975/03/07/
VL - 187
IS - 4179
M3 - Article
SP - 845
EP - 847
SN - 00368075
AB - Electrophysiologically identified pyramidal tract neurons in the rat cerebral cortex were tested with norepinephrine, acetylcholine, adenosine 3',5'- monophosphate (cyclic AMP), and guanosine 3',5'-monophosphate (cyclic GMP) applied by microiontophoresis. The neurons were usually inhibited by norepinephrine and cyclic AMP, but excited by acetylcholine and cyclic GMP. These opposing responses of pyramidal tract neurons to cyclic AMP and cyclic GMP suggests that these two nucleotides could function as reciprocal intracellular second messengers for norepinephrine and acetylcholine, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118646; STONE, T. W. 1; TAYLOR, D. A. 1; BLOOM, F. F. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p845; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KENNEDY, C.
AU - ROSIERS, M. H. DES
AU - JEHLE, J. W.
AU - REIVICH, M.
AU - SHARPE, F.
AU - SOKOLOFF, L.
T1 - Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with [14C]Deoxyglucose.
JO - Science
JF - Science
Y1 - 1975/03/07/
VL - 187
IS - 4179
M3 - Article
SP - 850
EP - 853
SN - 00368075
AB - If sufficient time has elapsed following an intravenous pulse of [14C]deoxyglucose, the carbon-14 contents of the tissues of the central nervous system represent mainly the accumulated phosphorylated derivative of [14C]deoxyglucose and reflect the rates of glucose consumption of the tissues. Altered functional activity alters metabolic activity and the uptake of [14C]deoxyglucose in the tissues. By autoradiographic survey of sections of the central nervous system it is then possible to map all the regions with altered functional and metabolic activities in response to experimentally induced changes in functional state. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118649; KENNEDY, C. 1; ROSIERS, M. H. DES 1; JEHLE, J. W. 1; REIVICH, M. 2; SHARPE, F. 3; SOKOLOFF, L. 4; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Neurology, University of Pennsylvania, Philadelphia 19174; 3: Laboratory of Neurophysiology, National Institute of Mental Health; 4: Laboratory of Cerebral Metabolism, National Institute of Mental Health; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p850; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHERR, CHARLES J.
AU - TODARO, GEORGE J.
T1 - Primate Type C Virus p3O Antigen in Cells from Humans with Acute Leukemia.
JO - Science
JF - Science
Y1 - 1975/03/07/
VL - 187
IS - 4179
M3 - Article
SP - 855
EP - 857
SN - 00368075
AB - Antigens related to the major structural protein (p30) of type C viruses isolated from a woolly monkey and a gibbon ape were found in peripheral white blood cells from five patients with acute leukemia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118651; SHERR, CHARLES J. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/ 7/1975, Vol. 187 Issue 4179, p855; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Karlowski, T. R.;
AU - Chalmers, T. C.;
AU - Frenkel, L. D.;
AU - Kapikian, A. Z.;
AU - Lewis, T. L.;
AU - \ET/;
T1 - Ascorbic acid for the common cold: prophylactic and therapeutic trial
CT - Ascorbic acid for the common cold: prophylactic and therapeutic trial
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1975/03/10/
VL - 231
IS - Mar 10
SP - 1038
EP - 1042
AD - Reprints: Mount Sinai Medical Center, Fifth Ave. and 100th St., New York, New York 10029
AD - National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-4634; Language: English; Chemical Name: Ascorbic acid--50-81-7; References: 12; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - A long-term prospective double-blind trial with high doses of ascorbic acid was designed to measure as well as distinguish between the prophylactic and therapeutic effects of the drug in treating the common cold. One g of ascorbic acid or lactose placebo in capsules was taken 3 times a day for 9 months by 311 volunteers. At the onset of a cold, patients were given an additional 3 g daily of either a placebo or ascorbic acid. One hundred ninety volunteers completed the study. Dropouts were defined as those who missed at least one month of drug ingestion. They represented 44% of the placebo group and 34% of those taking ascorbic acid. Analysis of these data showed that ascorbic acid had at best only a minor influence on the duration and severity of colds, and that the effects demonstrated might be explained equally well by a break in the double-blind.
KW - Ascorbic acid--colds-;
KW - Dosage--ascorbic acid--high, colds, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - SATTIN, ALBERT
AU - AXELROD, JULIUS
AU - KOPIN, IRWIN J.
AU - NAUTA, WALLE J. H.
T1 - Ilya Glezer's Struggle.
JO - Science
JF - Science
Y1 - 1975/03/14/
VL - 187
IS - 4180
M3 - Article
SP - 907
EP - 907
SN - 00368075
N1 - Accession Number: 85118656; SATTIN, ALBERT 1; AXELROD, JULIUS 2; KOPIN, IRWIN J. 2; NAUTA, WALLE J. H. 3; Affiliations: 1: Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106; 2: National Institute of Mental Health, Bethesda, Maryland 20014; 3: Department of Psychology, Massachusetts Institute of Technology, Cambridge 02139; Issue Info: 3/14/1975, Vol. 187 Issue 4180, preceding p907; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PRICE, PAUL J.
AU - SUK, WILLIAM A.
AU - SKEEN, PAMELA C.
AU - CHIRIGOS, MICHAEL A.
AU - HUEBNER, ROBERT J.
T1 - Transforming Potential of the Anticancer Drug Adriamycin.
JO - Science
JF - Science
Y1 - 1975/03/28/
VL - 187
IS - 4182
M3 - Article
SP - 1200
EP - 1201
SN - 00368075
AB - A Fischer rat embryo cell system in vitro, which had been shown to be highly accurate in identifying chemical carcinogens and to have application in the study of chemicals having anticancer properties, was used to study the anticancer drug adriamycin. At a nontoxic dose adriamycin not only did not protect the cells from transformation by the carcinogen 3-methylcholanthrene, but was found in two separate experiments to act on its own as a transforming agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118759; PRICE, PAUL J. 1; SUK, WILLIAM A. 1; SKEEN, PAMELA C. 1; CHIRIGOS, MICHAEL A. 2; HUEBNER, ROBERT J. 2; Affiliations: 1: Microbiological Associates, Bethesda, Maryland 20014; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/28/1975, Vol. 187 Issue 4182, p1200; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Gochman, N.;
AU - Young, D. S.;
T1 - Clinical chemistry
CT - Clinical chemistry
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1975/04/01/
VL - 47
IS - Apr
SP - 16R
EP - 37R
AD - VA Hospital, San Diego, California 92161 and National Institutes of Health Bethesda, Maryland 20014
N1 - Accession Number: 12-4437; Language: English; References: 771; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry; Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - This selective review of clinical chemistry covers the period from December 1972 to November 1974. The primary emphasis is on the development and evaluation of the analytical methodology of clinical chemistry, with only limited references to the extensive role of this specialty in clinical diagnosis, patient therapy, and biomedical research. Topics discussed include toxicology, drugs and vitamins, screening and profile techniques, and hormone analysis.
KW - Chemistry--clinical--review;
KW - Hormones--analysis--review, clinical chemistry;
KW - Drugs--analysis--review, clinical chemistry;
KW - Analysis--hormones--and drugs, clinical chemistry, review;
KW - Vitamins--analysis--review, clinical chemistry;
KW - Toxicity--chemistry--clinical, role;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chirigos, M. A.;
AU - Fuhrman, F. S.;
AU - Pryor, J. W.;
T1 - Prolongation of chemotherapeutically induced remission of a syngeneic murine leukemia by L-2,3,5,6-tetrahydro-6-phenylimidiazo(2,1-\LC/b\UC/)thiazole hydrochloride
CT - Prolongation of chemotherapeutically induced remission of a syngeneic murine leukemia by L-2,3,5,6-tetrahydro-6-phenylimidiazo(2,1-\LC/b\UC/)thiazole hydrochloride
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/04/01/
VL - 35
IS - Apr
SP - 927
EP - 931
SN - 00085472
AD - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-0098; Language: English; Trade Name: 1,3-bis(2-Chloroethyl)-1-nitrosourea--L-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride; Generic Name: Carmustine; Tetramisole; Chemical Name: Tetramisole--5036-02-2 Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents tetramisole; References: 28; Journal Coden: CNREA8; Section Heading: Drug Interactions; Preliminary Drug Testing
N2 - L-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride (tetramisole; I), when used with 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine; II) resulted in a significantly higher percentage of long term leukemia-free survivor mice. The additive effect provided by I treatment was evident during the immunosuppressed period induced by II treatment and when tumor load was minimal. Treatment with I alone did not appear to possess any significant antitumor effect. The beneficial effect of I treatment may be attributable to the immunostimulatory activity reported for this drug. It appears to be an excellent candidate for use as an immunostimulant in combination therapy.
KW - Tetramisole--interactions-;
KW - Carmustine--interactions-;
KW - Drug interactions--tetramisole and carmustine--leukemias, increased survival, comparison, tetramisole alone, in mice;
KW - Drug interactions--carmustine and tetramisole--leukemias, increased survival, comparison, tetramisole alone, in mice;
KW - Antineoplastic agents--carmustine--interactions, tetramisole, leukemias, increased survival, comparison, tetramisole alone, in mice;
KW - Antineoplastic agents--tetramisole--interactions, carmustine, leukemias, increased survival, comparison, tetramisole alone, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lippman, M. M.;
AU - Laster, W. R.;
AU - Abbott, B. J.;
AU - Venditti, J.;
AU - Baratta, M.;
T1 - Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma
CT - Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/04/01/
VL - 35
IS - Apr
SP - 939
EP - 945
SN - 00085472
AD - Drug Evaluation Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-0502; Language: English; Trade Name: NSC-170105; Generic Name: Macromomycin B; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents macromomycin B; References: 10; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2 - Mice bearing either L1210 or P388 leukemia, or B16 melanoma responded to IP injections of macromomycin B (NSC-170105; I) with significant increases in life-span. The maximal increases in life-span obtained in these experiments were 37% for L1210, 68% for P388 and 120% for B16. In addition, there were 7 of 30 cures for varying doses of I in the B16 melanoma. Activity of over 50% increase in life-span in B16 was obtained with a daily IP injection on days 1-9 of 16-40 mg/kg. Animals that had received SC implanted Lewis lung tumors responded to either single or repeated injections (8-16 mg/kg) given at the site of tumor implant by a marked reduction in growth of the primary tumor, increased life-span, and some cures. The reported activity of I against L1210 and P388 leukemias, B16 melanoma, and Lewis lung carcinoma make it a good candidate for development for clinical trial against human solid tumors. Responder analysis, a method of evaluating activity against solid tumors, is also presented.
KW - Macromomycin B--leukemia-;
KW - Antineoplastic agents--macromomycin B--leukemia, melanoma, and Lewis lung carcinoma, effects, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pearson, J. W.;
AU - Perk, K.;
AU - Chirigos, M. A.;
AU - Torgersen, J. A.;
T1 - Drug therapy against a transplantable guinea pig leukemia
CT - Drug therapy against a transplantable guinea pig leukemia
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/04/01/
VL - 35
IS - Apr
SP - 1093
EP - 1098
SN - 00085472
AD - Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-6100; Language: English; Trade Name: Cytoxan; Generic Name: Cyclophosphamide; Chemical Name: Cyclophosphamide--6055-19-2 Mercaptopurine--6112-76-1 Semustine--13909-09-6; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents semustine and cyclophosphamide (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 21; Journal Coden: CNREA8; Section Heading: Investigational Drugs
N2 - The effects of 6 clinically active drugs were tested against a transplantable leukemia in inbred strain 2 guinea pigs. Cytoxan (cyclophosphamide; I) and mercaptopurine were found to elicit a therapeutic response against this leukemia based on complete tumor regression of the established tumor as well as a substantial increase in survival time. Animals dying in the untreated control and drug-treated groups revealed typical generalized lymphoblastic leukemia. However, only I-treated animals that had relapsed exhibited central nervous system involvement originating from the arachnoid membrane. A 2-drug combination of I and semustine (II) was found not only to prevent meningeal leukemia development but also to cure all animals from their leukemia. This observation was based on a complete clinical, hematological, and histopathological remission period up to 176 days. The administration of II alone was observed not only to control the systemic leukemia but also to prevent central nervous system involvement. No relapses occurred after the first remission period was achieved in the groups of animals that received II.
KW - Cyclophosphamide--alone and with semustine-;
KW - Mercaptopurine--leukemias-;
KW - Semustine--and cyclophosphamide-;
KW - Antineoplastic agents--mercaptopurine--leukemias, transplantable, effects, in guinea pigs;
KW - Antineoplastic agents--semustine and cyclophosphamide--leukemias, transplantable, effects, in guinea pigs;
KW - Antineoplastic agents--cyclophosphamide--alone and with semustine, effects, transplantable leukemia, in guinea pigs;
KW - Combined therapy--semustine and cyclophosphamide--leukemias, transplantable, in guinea pigs;
KW - Combined therapy--cyclophosphamide and semustine--leukemias, transplantable, in guinea pigs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kerbel, R. S.
AU - Birbeck, M. S. C.
AU - Robertson, D.
AU - Cartwright, P.
T1 - ULTRASTRUCTURAL AND SEROLOGICAL STUDIES ON THE RESISTANCE OF ACTIVATED B CELLS TO THE CYTOTOXIC EFFECTS OF ANTI-IMMUNOGLOBULIN SERUM.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/04//
VL - 20
IS - 1
M3 - Article
SP - 161
EP - 177
PB - Wiley-Blackwell
SN - 00099104
AB - Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either the source of antiserum or complement, or on the presence of a mitotic inhibitor, colcemid. Immunoperoxidasestaining-electron microscopy techniques were applied to assess whether there was any conspicuous difference between unstimulated versus mitogen-stimulated, mitotic cells with respect to density or distribution of cell surface Ig. No such differences were found; furthermore, mitotic cells showed rapid classical 'patch and cap' formation of cell surface Ig when incubated with anti-Ig at room temperature, indicating the retention of fluid membrane dynamics by lymphocytes in this stage of the cell cycle. In contrast to this cytotoxic resistance. T or B lymphocytes in mitosis were found to be as sensitive, or more so, to lysis by various other antisera when compared to non-mitotic cells. Thus the resistance of mitotic B cells to the cytotoxic effects of anti-Ig serum seems unique and appears independent of any conspicuous quantitative or qualitative change in ceil surface Ig. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - ANTI-immunoglobulin autoantibodies
KW - MITOGENS
KW - MITOSIS
KW - IMMUNOGLOBULIN G
KW - ANTIGENS
N1 - Accession Number: 16100799; Kerbel, R. S. 1,2 Birbeck, M. S. C. 3 Robertson, D. 3 Cartwright, P. 3; Affiliation: 1: Fellow of The National Cancer Institute of Canada. 2: Department of Pathology, Queen's University, Kingston, Ontario, Canada. 3: Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London.; Source Info: Apr1975, Vol. 20 Issue 1, p161; Subject Term: B cells; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: MITOGENS; Subject Term: MITOSIS; Subject Term: IMMUNOGLOBULIN G; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Elin, R. J.;
AU - Vesell, E. S.;
AU - Wolff, S. M.;
T1 - Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance
CT - Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1975/04/01/
VL - 17
IS - Apr
SP - 447
EP - 457
SN - 00099236
AD - Lab. of Clinical Investigation, National Institute of Allergy and Infectious Diseases, N.I.H. and Dept. of Pharmacology, Bethesda, Maryland and Milton S. Hershey Medical Center, Pennsylvania State Univ. College of Medicine, Hershey, Pennsylvania
N1 - Accession Number: 12-5808; Language: English; Chemical Name: Antipyrine--60-80-0; References: 38; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The plasma half-life and metabolic clearance rate of antipyrine were determined in 33 normal volunteers during a basal state and during fever induced with a single IM injection of etiocholanolone (I). After the 14 normal volunteers who achieved significant fever, 11 experienced prolonged plasma antipyrine half-life after a single oral does of 10 mg/kg and decreased antipyrine metabolic clearance rate. There was no significant change in these mean values in 19 normal volunteers who failed to develop significant fever. Plasma antipyrine half-life prolongation was probably due to impaired hepatic metabolism during I-induced fever, although no correlation was observed between the magnitude of fever and the extent to which plasma antipyrine half-life was prolonged. Failure to obtain such a correlation may be attributable to the very small range of temperature elevation, extending from 37.9 DG C to 39.2 DG C, in the group of 14 subjects achieving significant I-induced fever. A higher dose of antipyrine (18 mg/kg) supressed induction of fever; antipyrine is the only orally administered drug thus far shown to be effective in repressing fever.
KW - Antipyrine--blood levels-;
KW - Blood levels--antipyrine--half-life, and effects, fever induced by etiocholanolone, in humans;
KW - Half-life--antipyrine--blood levels, and effects, fever induced by etiocholanolone, in humans;
KW - Metabolism--antipyrine--blood levels, and effects, fever induced by etiocholanolone, in humans;
KW - Excretion--antipyrine--blood levels, and effects on fever induced by etiocholanolone, in humans;
KW - Mechanism of action--antipyrine--metabolism, and effects on fever induced by etiocholanolone, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Reiter, E. O.;
AU - Kulin, H. E.;
T1 - Plasma testosterone response to short term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen
CT - Plasma testosterone response to short term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen
JO - Fertility and Sterility (USA)
JF - Fertility and Sterility (USA)
Y1 - 1975/04/01/
VL - 26
IS - Apr
SP - 340
EP - 345
SN - 00150282
AD - Reprints: Dept. of Pediatrics, Univ. of South Florida College of Medicine, All Children's Hospital, St. Petersburg, Florida 33701
AD - Reproduction Research Branch, National Institute of Child Health and Human Development, N.I.H., Bethesda, Maryland 20014
N1 - Accession Number: 12-6535; Language: English; References: 18; Journal Coden: FESTAS; Human Indicator: Yes; Section Heading: Pharmacology
N2 - To investigate the role of follicle stimulating hormone in Leydig cell function, 6 men were given 4 daily injections of 4,000 IU human chorionic gonadotropin (I) while receiving oral ethinyl estradiol. The peak testosterone levels were contrasted to the results obtained in 7 men who received I without additional exogenous steroid treatment. Urinary and plasma follicle stimulating hormone was suppressed to 26% and 50%, respectively, of basal values by the estrogen treatment. Peak plasma testosterone determinations following I did not differ in the 2 groups. Additionally, an early pubertal boy had a normal I-induced testosterone rise while his urnary follicle stimulating hormone was suppressed by estradiol to lower than prepubertal levels. The data indicate that short term follicle stimulating hormone suppression does not alter testicular responsivity to short term I administration. A role for follicle stimulating hormone in Leydig cell testosterone production in men has yet to be demonstrated.
KW - Gonadotropins--chorionic--human, effects on plasma testosterone levels via FSH suppression, in men;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Fauci, A.S.
T1 - Mechanisms of Corticosteroid Action on Lymphocyte Subpopulations I. REDISTRIBUTION OF CIRCULATING T AND B LYMPHOCYTES TO THE BONE MARROW.
JO - Immunology
JF - Immunology
Y1 - 1975/04//
VL - 28
IS - 4
M3 - Article
SP - 669
EP - 680
PB - Wiley-Blackwell
SN - 00192805
AB - The effect of corticosteroid administration on the redistribution of circulating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) caused a profound but transient lymphocytopenia which was maximal at 4 hours following injection, with a return to normal counts by 24 hours. There was a proportionately greater decrease in circulating T lymphocytes compared to B lymphocytes, although both populations were diminished. Chronic cortisone acetate treatment (100 mg/kg subcutaneously for 7 days) caused a similar pattern of lymphocytopenia except that it was sustained during the period of chronically elevated plasma cortisol levels. The lymphocytes remaining in the circulation during the period of lymphocytopenia responded normally in vitro to the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen. There was very little effect of corticosteroid administration on the numbers, proportions, or mitogenic response of splenic lymphocytes. There was a dramatic increase in the bone marrow of proportions and absolute numbers of lymphocytes bearing surface T- and B-cell markers, as well as a marked increase in response of bone marrow lymphocytes to mitogenic stimulation during the period of maximal circulating lymphocytopenia caused by the administration of corticosteroids, especially chronic cortisone acetate. There was a preferential horning of reinfused 51Cr-labelled syngeneic peripheral blood lymphocytes to the bone marrow of corticosteroid-treated recipients. These studies demonstrate a redistribution of circulating lymphocytes to the bone marrow during corticosteroid treatment, resulting in an increase in immunocompetence of this compartment, while the peripheral blood lymphocyte compartment is quantitatively immunosuppressed due to a lymphocytopenia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADRENOCORTICAL hormones
KW - LYMPHOCYTES
KW - BONE marrow
KW - GUINEA pigs
KW - T cells
KW - B cells
N1 - Accession Number: 13371919; Fauci, A.S. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr75, Vol. 28 Issue 4, p669; Subject Term: ADRENOCORTICAL hormones; Subject Term: LYMPHOCYTES; Subject Term: BONE marrow; Subject Term: GUINEA pigs; Subject Term: T cells; Subject Term: B cells; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Hurley, D. L.;
AU - Barlow, J. E.;
AU - Fauci, A. S.;
T1 - Experimental disseminated candidiasis. 2. Administration of glucocorticosteroids, susceptibility to infection and immunity
CT - Experimental disseminated candidiasis. 2. Administration of glucocorticosteroids, susceptibility to infection and immunity
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1975/04/01/
VL - 132
IS - Apr
SP - 393
EP - 398
SN - 00221899
AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-2191; Language: English; References: 35; Journal Coden: JIDIAQ; Section Heading: Toxicity
N2 - A model of experimental disseminated candidiasis in inbred guinea pigs was used for study of the effects of both short and long acting glucocorticosteroid administration on the susceptibility to infection, the development of in vivo and in vitro parameters of cell mediated immunity, and the expression of already established candida specific, cell mediated immunity. Results revealed that long acting glucocorticoids markedly potentiate infection, increasing mortality and suppress already established cellular immune parameters. Short acting glucocorticosteroids did not potentiate infection and they affected neither the development nor the expression of immune parameters.
KW - Steroids, cortico---toxicity--candidiasis, potentiation, and suppression of immune parameters, in guinea pigs;
KW - Toxicity--steroids, cortico---candidiasis, potentiation, and suppression of immune parameters, in guinea pigs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cone, E. J.;
AU - Gorodetzky, C. W.;
AU - Yeh, S. Y.;
T1 - Biosynthesis, isolation, and identification of 6\b/-hydroxynaltrexone, a major human metabolite of naltrexone
CT - Biosynthesis, isolation, and identification of 6\b/-hydroxynaltrexone, a major human metabolite of naltrexone
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/04/01/
VL - 64
IS - Apr
SP - 618
EP - 621
SN - 00223549
AD - Div. of Research Addiction Research Ctr., National Institute on Drug Abuse, Lexington, Kentucky 40511
N1 - Accession Number: 13-0811; Language: English; Chemical Name: Naltrexone--16590-41-3; References: 5; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
N2 - Pilot metabolic studies on naltrexone in the dog, rat and guinea pig were made to determine which animal produced the greatest amount of 6\b/-hydroxynaltrexone. The guinea pig was selected and used to produce the metabolite. Isolation and purification methods are described, and mass and infrared spectral data are presented for structural confirmation of the metabolite.
KW - 6\b/-Hydroxynaltrexone--biosynthesis-;
KW - Naltrexone--metabolism-;
KW - Structure--6\b/-hydroxynaltrexone--isolation, and identification, in guinea pigs;
KW - Spectrometry, infrared--6\b/-hydroxynaltrexone--structure, in guinea pigs;
KW - Spectrometry, mass--6\b/-hydroxynaltrexone--structure, in guinea pigs;
KW - Metabolism--naltrexone--biosynthesis, 6\b/-hydroxynaltrexone, isolation and identification, in guinea pigs;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Graepel, P H
AU - Henson, D E
AU - Pratt, A W
T1 - Comments on the use of the systematized nomeclature of pathology
JO - Methods of Information in Medicine
JF - Methods of Information in Medicine
Y1 - 1975/04//
VL - 14
IS - 2
M3 - Article
SP - 72
EP - 75
SN - 00261270
AB - Any discussion of the use of the systematized nomenclature of pathology (snop) requires comprehension of the principles of organization of snop. Snop is a categorized nomenclature which lists 'names' of elements and concepts of pathology. Snop contains four lists of pathology names and concepts known as topography, morphology, etiology and function. Clearly, snop is not a diagnostic code or a coded medical terminology; to use snop the user must specify the coding structure. Thus snop is a basis for building a medical data code. The advantage of a categorized nomenclature is that it is possible to construct a well-defined information space for medical data based on the semantic value of the data and apart from some predetermined numeric code where terms are assigned as a function of the number structure. Thus it has been possible to explore the automatic processing of pathology language data. An automatic encoding capabality has been used at nih to encode surgical pathology data these encoded data were used to study the deficiencies of snop and to evaluate new structures for a truly categorized nomenclature of medicine. This new lexical structure can only be achieved if the pathologists waive traditional practices of assigning names to concepts of pathology and allow for new dimensions of medical ways of thinking which go beyond pure morphology.
N1 - Accession Number: ISTA1001488; Graepel, P H 1; Henson, D E; Pratt, A W; Affiliations: 1 : Division Of Computer Research And Technology And Laboratory Of Pathology, National Cancer Institute, National Institutes Of Health, Bethesda, Maryland.; Source Info: April 1975, Vol. 14 Issue 2, p72; Note: Update Code: 1000; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2013-42018-004
AN - 2013-42018-004
AU - Lystad, Mary Hanemann
T1 - Violence at home: A review of the literature.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1975/04//
VL - 45
IS - 3
SP - 328
EP - 345
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Lystad, Mary Hanemann, National Institute of Mental Health, 5600 Fishers Lane, Rockville, NY, US, 20852
N1 - Accession Number: 2013-42018-004. PMID: 1096636 Partial author list: First Author & Affiliation: Lystad, Mary Hanemann; Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, NY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Domestic Violence; Psychological Assessment; Social Norms; Sociocultural Factors. Minor Descriptor: Intimacy; Social Issues. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 18. Issue Publication Date: Apr, 1975.
AB - Studies on family violence have analyzed the phenomenon from psychological, social, and cultural perspectives. A review of the literature shows that the available evidence is not contradictory, leading to the conclusion that a comprehensive theory of violence at home must take into account factors at these several levels, placing individual functioning within the social group and within the culture norms by which the group operates. A theory of violence at home, and suggestions for further research, are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violence at home
KW - psychological perspectives
KW - social perspectives
KW - cultural perspectives
KW - culture norms
KW - intimacy
KW - 1975
KW - Domestic Violence
KW - Psychological Assessment
KW - Social Norms
KW - Sociocultural Factors
KW - Intimacy
KW - Social Issues
KW - 1975
DO - 10.1111/j.1939-0025.1975.tb02544.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42018-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42018-027
AN - 2013-42018-027
AU - Shore, Milton F.
T1 - Review of Existing patterns of services for alcoholism and drug dependence: Report of a study; Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group; Psychiatry and primary medical care: Report on a working group; and The role of the psychologist in mental health services: Report on a working group.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1975/04//
VL - 45
IS - 3
SP - 505
EP - 506
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42018-027. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alcoholism; Mental Health Services; Primary Health Care; Rehabilitation; Treatment. Minor Descriptor: Mental Health; Psychiatry; Psychologists. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Ozarin, Lucy. Existing patterns of services for alcoholism and drug dependence: Report of a study=(EURO 5437 IV.) 146 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group=(EURO 5423 IV.) 103 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. Psychiatry and primary medical care: Report on a working group=(EURO 5427 1.) 45 pp. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. No authorship indicated. The role of the psychologist in mental health services: Report on a working group=(EURO 5428 1.) 47 op. Regional Office, World Health Organization, Copenhagen, Denmark; 1973. Page Count: 2. Issue Publication Date: Apr, 1975.
AB - Reviews the books, Existing Patterns of Services for Alcoholism and Drug Dependence: Report of a Study (1973), Comparison and Evaluation of Methods of Treatment and Rehabilitation for Drug Dependence and Abuse: Report on a Working Group (1973), Psychiatry and Primary Medical Care: Report on a Working Group (1973) and The Role of the psychologist in Mental Health Services: Report on a Working Group (1973). Any mention of the World Health Organization is bound to elicit in many professionals an immediate association to the classic work by John Bowl by, 'Maternal Care and Mental Health,' one of the earliest publications of the Organization, and one that has had a profound effect on the care of preschool children over the last two decades. The reports reviewed here are but a few of those available gratis from that office to those persons officially and professionally concerned about a specific field of mental health. The European Regional Office has gone far beyond just offering opportunities for people from different countries to exchange opinions. It has focused on broad studies of mental health structures in European countries with differing political, social, and economic conditions. The broad definition of mental health, which encompasses public health, social welfare, and educational elements, as well as the classic medical components, generates many approaches relevant to programs in the United States. These are work documents which focus on action. As a result they serve to narrow the gap between the theoretician and the practitioner, a gap that has been widening rather than narrowing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - existing patterns
KW - alcoholism
KW - drug dependence
KW - treatment processes
KW - rehabilitation
KW - medical care
KW - mental health
KW - 1975
KW - Alcoholism
KW - Mental Health Services
KW - Primary Health Care
KW - Rehabilitation
KW - Treatment
KW - Mental Health
KW - Psychiatry
KW - Psychologists
KW - 1975
U2 - Ozarin, Lucy. (1973); Existing patterns of services for alcoholism and drug dependence: Report of a study; (EURO 5437 IV.) 146 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2 - No authorship indicated. (1973); Comparison and evaluation of methods of treatment and rehabilitation for drug dependence and abuse: Report on a working group; (EURO 5423 IV.) 103 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2 - No authorship indicated. (1973); Psychiatry and primary medical care: Report on a working group; (EURO 5427 1.) 45 pp. Regional Office, World Health Organization, Copenhagen, Denmark
U2 - No authorship indicated. (1973); The role of the psychologist in mental health services: Report on a working group; (EURO 5428 1.) 47 op. Regional Office, World Health Organization, Copenhagen, Denmark
DO - 10.1037/h0098740
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42018-027&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SEGERLING, MARTIN
AU - OHANIAN, SARKIS H.
AU - BORSOS, TIBOR
T1 - Chemotherapeutic Drugs Increase Killing of Tumor Cells by Antibody and Complement.
JO - Science
JF - Science
Y1 - 1975/04/04/
VL - 188
IS - 4183
M3 - Article
SP - 55
EP - 57
SN - 00368075
AB - When the ascitic forms of two antigenically distinct guinea pig hepatomas induced by diethylnitrosamine are treated in vitro with chemotherapeutic drugs, their sensitivity to killing by xenogeneic antibody plus guinea pig complement increases. The effect is dependent on drug dose, is reversible, and does not appear to be due to increased antigen expression or fixation of the early acting components of guinea pig complement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118802; SEGERLING, MARTIN 1; OHANIAN, SARKIS H. 1; BORSOS, TIBOR 1; Affiliations: 1: Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 4/1975, Vol. 188 Issue 4183, p55; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOONE, CHARLES W.
T1 - Malignant Hemangioendotheliomas Produced by Subcutaneous Inoculation of Balb/3T3 Cells Attached to Glass Beads.
JO - Science
JF - Science
Y1 - 1975/04/04/
VL - 188
IS - 4183
M3 - Article
SP - 68
EP - 70
SN - 00368075
AB - The Balb/3T3 mouse embryo cell line has been frequently used in cancer research as representative of nontumorigenic cells with the characteristic in vitro properties of postconfluence inhibition of cell division, low saturation density, and anchorage dependence. On the reasoning that anchorage dependence might also apply in vivo, each of nine mnice were subcutaneously inoculated with an average of 15,400 Balb/3T3 cells attached to two glass beads 3 millimeters in diameter. After 8 weeks, all the mice had developed large bloody tumors that microscopically proved to be hemangioendotheliomas. The inoculation of Balb/3T3 cells alone or beads alone produced no tumors. Transplants of each tumor into normal mice grew to kill the animal within 6 weeks. Tumor cells from collagenase- disaggregated tumor tissue had a plating efficiency of 21.2 percent conipared to that of normal adult subcutaneous fibroblasts of less than 0.1 percent. The tumor cells in vitro closely resembled Balb/3T3 cells in appearance and were tumorigenic at a dose of 105 cells. A second, repeat experimnent produced the same type of tumors grossly and microscopically in 17 of 25 mice between 99 and 211 days after inoculation of the Balb/3T3 cells attached to glass beads. These findings require a reassessmtient of the postulate that low saturation density, postconfluence of cell division, and amichorage dependence are characteristic in vitro properties only of nonneoplastic cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118808; BOONE, CHARLES W. 1; Affiliations: 1: Cell Biology Section, Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 4/1975, Vol. 188 Issue 4183, p68; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HENKART, MARYANNA
T1 - Light-Induced Changes in the Structure of Pigmented Granules in Aplysia Neurons.
JO - Science
JF - Science
Y1 - 1975/04/11/
VL - 188
IS - 4184
M3 - Article
SP - 155
EP - 157
SN - 00368075
AB - Pigmented granules in Aplysia neurons prepared in the dark contain material that appears to be composed of 50-angstrom globules and a precipitate, probably a calcium salt. On illumination the globules rearrange into paracrystalline arrays and membrane-like lamellae. The morphologic transformation may be related to calcium release from the granules, and the released calcium may mediate the light-evoked hyperpolarization described by others. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118842; HENKART, MARYANNA 1; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/11/1975, Vol. 188 Issue 4184, p155; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHECHTER, I.
AU - MCKEAN, D. J.
AU - GUYER, R.
AU - TERRY, W.
T1 - Partial Amino Acid Sequence of the Precursor of Immunoglobulin Light Chain Programmed by Messenger RNA in vitro.
JO - Science
JF - Science
Y1 - 1975/04/11/
VL - 188
IS - 4184
M3 - Article
SP - 160
EP - 162
SN - 00368075
AB - The five proteins programmed in a cell-free system by a mouse kappa light chain messenger RNA were labeled with [³H]leucine and subjected to amino acid sequence analyses. In all five proteins, 20 amino acid residues precede the amino terminus of the mature protein, indicating that there is one major point for the initiation of messenger RNA translation. The abundance (30 percent) of leucine residues in the extra piece (leucine at positions 6, 7, 8, 11, 12, and 13) indicates that this moiety is hydrophobic. Furthermore, it seems that the precursor may have an additional extra piece at the carboxyl terminus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118844; SCHECHTER, I. 1; MCKEAN, D. J. 2; GUYER, R. 3; TERRY, W. 3; Affiliations: 1: Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel; 2: Department of Medical Genetics, University of Wisconsin, Madison 53706; 3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/11/1975, Vol. 188 Issue 4184, p160; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Ransom, B. R.;
AU - Barker, J. L.;
T1 - Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture
CT - Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture
JO - Nature (London)
JF - Nature (London)
Y1 - 1975/04/24/
VL - 254
IS - Apr 24
SP - 703
EP - 705
AD - Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-1107; Language: English; Chemical Name: Pentobarbital--76-74-4; Therapeutic Class: (28:04); AHFS Class: Anesthetics pentobarbital; References: 18; Publication Type: Letters; Journal Coden: NATUAS; Section Heading: Pharmacology; Abstract Author: William H. Jeffery
N2 - General anesthetics depress postsynaptic excitatory transmission in the vertebrate central and peripheral nervous systems, although preserving or prolonging both presynaptic and postsynaptic inhibition. Using intracellular recording from mouse spinal neurones grown in tissue culture, it is shown that pentobarbital depresses glutamate excitation and prolongs \g/-aminobutyric acid inhibition in most cells, through a postsynaptic mechanism.
KW - Pentobarbital--anesthesia-;
KW - Anesthetics--pentobarbital--mechanism of action, discussion;
KW - Mechanism of action--pentobarbital--anesthesia, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - WALLACE, G. D.
AU - FRENKEL, J. K.
T1 - Besnoitia Species (Protozoa, Sporozoa, Toxoplasmatidae): Recognition of Cyclic Transmission by Cats.
JO - Science
JF - Science
Y1 - 1975/04/25/
VL - 188
IS - 4186
M3 - Article
SP - 369
EP - 371
SN - 00368075
AB - Isosporan oocysts, measuring 13 by 16 micrometers, from a cat in Hawaii produced Besnoitia cysts in tissues of mice and rats. Feeding these cysts to cats led to oocyst shedding after 11 to 13 days, continuing for a mean of 11 days. This indicates a two-host cycle for Besnoitia, adding an intestinal phase and oocyst production by a carnivore to the already known tissue stages. Thus a representative of Besnoitia, similar to other species in cattle, horses, reindeer, impala, other mammals, and reptiles, has been shown to be a coccidian of cats, capable of being spread by fecal contamination. Besnoitia is the fourth mammalian tissue parasite, together with Toxoplasma, Hammondia, and Sarcocystis, found to produce isosporan-type oocysts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136165; WALLACE, G. D. 1; FRENKEL, J. K. 2; Affiliations: 1: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Honolulu, Hawaii 96806; 2: Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103; Issue Info: 4/25/1975, Vol. 188 Issue 4186, p369; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Oster, M. W.;
AU - Gelrud, L. G.;
AU - Lotz, M. J.;
AU - Herzig, G. P.;
AU - Johnston, G. S.;
T1 - Psoas abscess localization by gallium scan in aplastic anemia
CT - Psoas abscess localization by gallium scan in aplastic anemia
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1975/04/28/
VL - 232
IS - Apr 28
SP - 377
EP - 379
AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-4272; Language: English; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals gallium citrate; References: 9; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - This report is concerned with a patient with aplastic anemia and severe granulocytopenia in whom the gallium citrate Ga 67 scintiscan was useful in diagnosing a previously undetected inflammatory lesion.
KW - Gallium citrate--Ga 67-;
KW - Radiopharmaceuticals--gallium citrate--Ga 67, scintiscan, inflammatory lesion, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bender, R. A.;
AU - Bleyer, W. A.;
AU - Frisby, S. A.;
AU - Oliverio, V. T.;
T1 - Alteration of methotrexate uptake in human leukemia cells by other agents
CT - Alteration of methotrexate uptake in human leukemia cells by other agents
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/05/01/
VL - 35
IS - May
SP - 1305
EP - 1308
SN - 00085472
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 12-6147; Language: English; Chemical Name: Methotrexate--59-05-2 Hydrocortisone--50-23-7 Cephalothin--153-61-7 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate (68:04); AHFS Class: Steroids, cortico- hydrocortisone (10:00); AHFS Class: Antineoplastic agents vincristine; References: 15; Journal Coden: CNREA8; Section Heading: Drug Interactions
N2 - The uptake of methotrexate (I) and the effects of drugs known to either inhibit or enhance I transport in L1210 murine leukemia were studied in man by using blast cells from patients with acute myelogenous leukemia in vitro. I uptake was found to proceed slowly, requiring at least 160 min for cells to reach a steady state when extracellular I concentrations were 1 micromole. Efflux of I from preloaded cells required 80-120 min and the nonexchangeable or tightly bound fraction was 40% of the total intracellular drug. Utilizing doses that are estimates of achievable peak blood levels following single IV injection, cephalothin, 21 mcg/ml, and hydrocortisone, 20 mcg/ml, inhibited net I accumulation by 20 and 28%, respectively. Vincristine sulfate, at 8.3 and 0.083 mcg/ml enhanced I uptake by 54 and 33%, respectively, by inhibiting I efflux, thus increasing the level of intracellular drug in excess of the tightly bound fraction. The potential clinical implications of using I in combination with the above drugs for cancer chemotherapy are discussed.
KW - Methotrexate--interactions-;
KW - Hydrocortisone--interactions-;
KW - Cephalothin--interactions-;
KW - Vincristine--interactions-;
KW - Drug interactions--methotrexate and cephalothin--effects, absorption in human blast cells, in vitro;
KW - Drug interactions--methotrexate and hydrocortisone--effects, absorption in human blast cells, in vitro;
KW - Drug interactions--methotrexate and vincristine--effects, absorption in human blast cells, in vitro;
KW - Drug interactions--vincristine and methotrexate--effects, absorption in human blast cells, in vitro;
KW - Drug interactions--hydrocortisone and methotrexate--effects, absorption in human blast cells, in vitro;
KW - Drug interactions--cephalothin and methotrexate--effects, absorption in human blast cells, in vitro;
KW - Absorption--methotrexate--interactions, effects, in human blast cells, in vitro;
KW - Metabolism--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW - Blood levels--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW - Antineoplastic agents--methotrexate--interactions, effects on absorption in human blast cells, in vitro;
KW - Steroids, cortico---hydrocortisone--interactions, methotrexate, effects on absorption by human blast cells, in vitro;
KW - Antineoplastic agents--vincristine--interactions, methotrexate, effects on absorption by human blast cells, in vitro;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Young, D. S.;
AU - Pestaner, L. C.;
AU - Friedman, R. B.;
T1 - Laboratory oriented computerized drug information system
CT - Laboratory oriented computerized drug information system
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 182
EP - 189
SN - 00928615
AD - Clinical Pathology Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-5697; Language: English; References: 6; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The structure and uses of the Computerized Listing of Abnormal and Unusual Drug Effects (CLAUDE), developed by the National Institutes of Health, are discussed. CLAUDE was developed to facilitate the correct interpretation of laboratory data by physicians and clinical laboratory scientists. The data base contains approximately 17,500 effects, both in vivo and in vitro, for 1500 drugs on laboratory tests.
KW - Computerized Listing of Abnormal and Unusual Drug Effects--design--and applications, discussion;
KW - Drug information--Computerized Listing of Abnormal and Unusual Drug Effects--design, and applications, discussion;
KW - Automation, data processing, computers--Computerized Listing of Abnormal and Unusual Drug Effects--design, and applications, discussion;
KW - Drug interactions--tests, laboratory and drugs--Computerized Listing of Abnormal and Unusual Drug Effects;
KW - Tests, laboratory--interactions--drugs, Computerized Listing of Abnormal and Unusual Drug Effects;
KW - Drug interactions--drugs and tests, laboratory--Computerized Listing of Abnormal and Unusual Drug Effects;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5697&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bellicha, T. C.;
AU - Campbell, K. A.;
T1 - Targeted information concept. The National Clearinghouse for Alcohol Information
CT - Targeted information concept. The National Clearinghouse for Alcohol Information
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 199
EP - 205
SN - 00928615
AD - National Clearinghouse for Alcohol Information, National Institute on Alcohol Abuse and Alcoholism, Gaithersburg, Maryland 20760
N1 - Accession Number: 13-5382; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The purpose, organization, and operation of the services of the National Clearinghouse for Alcohol Information are detailed. Problems in the acquisition, classification, and dissemination of alcohol related information are discussed as well as methods of identifying potential users of this specialized collection.
KW - Alcohols, ethyl--drug information-;
KW - National Clearinghouse for Alcohol Information--organization--and purpose, discussion;
KW - Drug information--National Clearinghouse for Alcohol Information--organization, and purpose;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5382&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Leeds, A. A.;
T1 - International Reference Centers Network\M/an unusual information resource
CT - International Reference Centers Network\M/an unusual information resource
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 219
EP - 223
SN - 00928615
AD - International Reference Center for Information on Psychotropic Drugs, Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 13-6329; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The organization, publications, and activities of the International Reference Centers Network for Information on Psychotropic Drugs are discussed as a model system for international cooperation in the exchange of scientific information.
KW - International Reference Centers Network for Information on Psychotropic Drugs--organization--publications, and activities, discussion;
KW - Literature--International Reference Centers Network for Information on Psychotropic Drugs--publications, discussion;
KW - Drug information--International Reference Centers Network for Information on Psychotropic Drugs--organization, publications and activities, discussion;
KW - Psychotherapeutic agents--literature--International Reference Centers Network for Information on Psychotropic Drugs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schneider, J. H.;
T1 - International cancer data bank as a potential source of drug, carcinogenic, and toxicologic information
CT - International cancer data bank as a potential source of drug, carcinogenic, and toxicologic information
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 233
EP - 238
SN - 00928615
AD - Office of International Affairs, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-5696; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The working plans for the various products and services of the International Cancer Research Data Bank (ICRDB) and an overview of the flow of information through the system are presented. The 4 segments of the ICRDB program are described with special emphasis being given to the Cancer Information Dissemination and Analysis (CIDA) segment. CIDA embodies the active program of information dissemination which includes SDI services to cancer researchers and the CANCERLINE information network. Other segments of the program are concerned with scientist-to-scientist communication, clinical data methods, and support for special information projects at the NCI.
KW - International Cancer Research Data Bank--services--discussion;
KW - Drug information--International Cancer Research Data Bank--services, discussion;
KW - Cancer--drug information--International Cancer Research Data Bank, services;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lachter, S. B.;
T1 - Acquisition of drug abuse information for the National Clearinghouse for Drug Abuse Information
CT - Acquisition of drug abuse information for the National Clearinghouse for Drug Abuse Information
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
IS - May-Sep
SN - 00928615
AD - National Clearinghouse for Drug Abuse Information, National Institute on Drug Abuse, 11400 Rockville Pike, Rockville, Maryland 20852
N1 - Accession Number: 13-5375; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - A list of publication titles which provide relevant information on drug abuse in the United States is given. The titles of the publications are classified under the following headings: scientific journal literature, drug abuse newsletter, popular magazines, underground press, dissertation literature, government reports, books, and law and legislation.
KW - Drug abuse--information--sources, for National Clearinghouse for Drug Abuse Information;
KW - Drug information--abuse--sources, for National Clearinghouse for Drug Abuse Information;
KW - National Clearinghouse for Drug Abuse Information--sources--literature;
KW - Literature--drug information--sources, for National Clearinghouse for Drug Abuse Information;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Cameron-Otero, Rafael D.
AU - Franklin, Richard M.
T1 - Structure and Synthesis of a Lipid-Containing Bacteriophage.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/05//May75 Part 1
VL - 53
IS - 2
M3 - Article
SP - 343
EP - 348
PB - Wiley-Blackwell
SN - 00142956
AB - Several physical and chemical parameters of bacteriophage PM2 have been measured. The sedimentation constant was determined to be s20,w° = 293 S. The buoyant density in sucrose at 20 °C was 1.24 g cm-3 and in CsCl at 25 °C was 1.29 g cm-3. The high-speed equilibrium centrifugation method of Yphantis (1964) was used to measure the molecular weight of PM2. The necessary auxiliary parameters were also determined. A value of 0.771 ± 0.005 cm3 g-1 for the apparent specific volume at constant chemical potential in 1 M sodium chloride has been obtained by pychometry; the viral concentration was determined using the absorption coefficient at 260 nm (4.60 ± 0.10 cm2 mg-1), which in turn was calculated from the phosphorous content of the virus (17.89 ± 0.28 μg of P per mg dry weight of virus). The molecular weight of PM2 determined with these parameters is (44.1 ± 1.2 × 106). From the phosphorous content of the virus, the percentage of phosphorus known to be in its DNA (CameriniOtero and Franklin, 1972), and the molecular weight of the bacteriophage, we have calculated a molecular weight for PM2 DNA of 6.26 × 106, which confirms values determined using empirical relationships. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIOPHAGES
KW - MICROBIOLOGY
KW - BACTERIOLOGY
KW - VIRUSES
KW - LIPIDS
KW - BIOMOLECULES
KW - PHOSPHORUS
KW - SALT
N1 - Accession Number: 15801960; Cameron-Otero, Rafael D. 1,2 Franklin, Richard M. 1,3; Affiliation: 1: The Public Health Research Institute of the City of New York 2: Laboratory of Molecular Biology, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland, U.S.A. 20014 3: Abteilung Strukturbiologie, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland; Source Info: May75 Part 1, Vol. 53 Issue 2, p343; Subject Term: BACTERIOPHAGES; Subject Term: MICROBIOLOGY; Subject Term: BACTERIOLOGY; Subject Term: VIRUSES; Subject Term: LIPIDS; Subject Term: BIOMOLECULES; Subject Term: PHOSPHORUS; Subject Term: SALT; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Powell, John A.
AU - Whalen, John J.
AU - Levis, William R.
T1 - STUDIES ON THE CONTACT SENSITIZATION OF MAN WITH SIMPLE CHEMICALS. !V. Timing of Skin Reactivity, Lymphokine Production, and Blastogenesis Following Rechallenge with Dinotrochlorobenzene using an Automated Microassay.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/05//
VL - 64
IS - 5
M3 - Article
SP - 357
EP - 363
SN - 0022202X
AB - An automated microassay was adapted to the study of specific in vitro lymphocyte transformation to dinitrochlorohenzene (DNCB) erythrocyte complexes (DNCB-antigen). Studies of culture conditions indicated that in flat-bottomed microtiter culture plates, 0.2-ml cultures containing 4 × 1o5 leukocytes and a total culture time of 4 or 5 days yield satisfactory results for the relatively low responses seen with specific antigens such as DNCB-antigen. Cultures were incubated for 3 hr with tritiated thymidine and harvested with the Multiple Automated Sample Harvester (MASH II). The effect of DNCB rechallenge on in vitro lymphocyte transformation was studied using this automated microassay. DNCB rechallenge boosted the in vitro response to DNCB-antigen, and in leukocyte cultures from some subjects the blastogenic response tended to remain elevated longer than has been reported following primary sensitization with DNCB. During a primary sensitization with DNCB, in vitro lymphocyte transformation to DNCB-antigen converted at about the same time skin reactivity was first observed, usually after about 2 weeks. However, following patch test rechallenge, skin reactivity was maximal at 2 to 3 days, whereas in vitro lymphocyte transformation to DNCB-antigen was nearly undetectable at 2 to 3 days and increased rapidly during the second week. The induction of lymphokine production following patch test rechallenge manifested a time course similar to that observed for specific lymphocyte transformation to DNCB-antigen. While the reasons for the observed temporal relationships between skin reactivity, blastogenesis, and lymphokine production are still unknown, knowledge of these relationships may provide insight on mechanisms of cellular immunity in man. In addition, awareness of these temporal relationships may allow a more rational approach to the in vitro study of naturally occurring contact sensitizers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - DINITROCHLOROBENZENE
KW - ERYTHROCYTES
N1 - Accession Number: 12512289; Powell, John A. 1 Whalen, John J. 1 Levis, William R. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: May75, Vol. 64 Issue 5, p357; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: DINITROCHLOROBENZENE; Subject Term: ERYTHROCYTES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12512289
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Kahn, C. R.;
AU - Levy, A. G.;
AU - Gardner, J. D.;
AU - Miller, J. V.;
AU - Gorden, P.;
T1 - Pancreatic cholera: beneficial effects of treatment with streptozotocin
CT - Pancreatic cholera: beneficial effects of treatment with streptozotocin
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1975/05/01/
VL - 292
IS - May 1
SP - 941
EP - 945
SN - 00284793
AD - Bldg. 10, Room 8N-240, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 12-4244; Language: English; References: 40; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Two patients with pancreatic cholera and islet cell carcinoma were treated with intra-arterial streptozotocin. Before therapy, each had stool volumes from 2 to 8 l/day and required 200 to 800 meq/day of supplemental potassium. After 3 to 5 doses of streptozotocin (1.5g/sq m), both stool volume and number and size of hepatic metastases decreased markedly. One patient has had normally formed stools for 12 months; the other had a 90% reduction in stool volume for 13 months with additional therapy. Both patients' serum potassium returned to normal without need for supplementation. Jejunal adenylate cyclase activity was normal in both, and plasma vasoactive intestinal peptide was detectable in only one. After chemotherapy, these findings showed no consistent change. Pharmacologic studies suggest that arterial administration increased either tumor or hepatic extraction (or both) of streptozotocin by 2 times and decreased renal exposure to this nephrotoxic drug by one third.
KW - Streptozotocin--cholera-;
KW - Cholera--streptozotocin--pancreatic, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chabner, B. A.;
AU - Myers, C. E.;
AU - Coleman, C. N.;
AU - Johns, D. G.;
T1 - Clinical pharmacology of antineoplastic agents. Parts 1 and 2
CT - Clinical pharmacology of antineoplastic agents. Parts 1 and 2
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1975/05/01/
VL - 21
IS - May 22; May 29
SP - 1107
EP - 1167
SN - 00284793
AD - Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 6N110, Bethesda, Maryland 20014
N1 - Accession Number: 12-5282; Language: English; Trade Name: 5-Fluorouracil--Adriamycin; Generic Name: Fluorouracil; Doxorubicin; Chemical Name: Fluorouracil--51-21-8 Methotrexate--59-05-2 Doxorubicin--23214-92-8 Bleomycin--11056-06-7 Cyclophosphamide--6055-19-2 Cytidine--65-46-3 Nitrosourea--13010-20-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents fluorouracil (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents bleomycin (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents cytidine (10:00); AHFS Class: Antineoplastic agents deoxycytidine (10:00); AHFS Class: Antineoplastic agents nitrosourea; References: 159; Journal Coden: NEJMAG; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Recent advances in the pharmacology of 5-fluorouracil, methotrexate, cytidine and deoxycytidine analogs, adriamycin (doxorubicin), bleomycin, nitrosoureas and cyclophosphamide are discussed.
KW - Fluorouracil--pharmacology-;
KW - Methotrexate--pharmacology-;
KW - Doxorubicin--pharmacology-;
KW - Bleomycin--pharmacology-;
KW - Cyclophosphamide--pharmacology-;
KW - Cytidine--derivatives-;
KW - Deoxycytidine--derivatives-;
KW - Nitrosourea--derivatives-;
KW - Antineoplastic agents--fluorouracil--pharmacology, discussion;
KW - Antineoplastic agents--methotrexate--pharmacology, discussion;
KW - Antineoplastic agents--doxorubicin--pharmacology, discussion;
KW - Antineoplastic agents--bleomycin--pharmacology, discussion;
KW - Antineoplastic agents--cyclophosphamide--pharmacology, discussion;
KW - Antineoplastic agents--cytidine--derivatives, pharmacology, discussion;
KW - Antineoplastic agents--deoxycytidine--derivatives, pharmacology, discussion;
KW - Antineoplastic agents--nitrosourea--derivatives, pharmacology, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Weiss, Theodore
AU - Engel, Bernard T.
T1 - Evaluation of an Intra-Cardiac Limit of Learned Heart Rate Control.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1975/05//
VL - 12
IS - 3
M3 - Article
SP - 310
EP - 312
SN - 00485772
AB - Operant conditioning to Increase ventricular heart rate (VHR) was carried out in 3 subjects (Ss) with complete heart block. None or the Ss increased VHR consistently. This finding suggests that operant conditioning of VHR is possible only when the conduction path between atria and ventricles is not interrupted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPERANT conditioning
KW - HEART beat
KW - HEART atrium
KW - HEART block
KW - CONDITIONED response
KW - HEART diseases
KW - Complete heart block
KW - Operant conditioning
KW - Ventricular heart rate.
N1 - Accession Number: 12320900; Weiss, Theodore 1 Engel, Bernard T. 1; Affiliation: 1: Section of Physiological Psychology, Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute of Child Health and Human, Development, Baltimore City Hospitals.; Source Info: May1975, Vol. 12 Issue 3, p310; Subject Term: OPERANT conditioning; Subject Term: HEART beat; Subject Term: HEART atrium; Subject Term: HEART block; Subject Term: CONDITIONED response; Subject Term: HEART diseases; Author-Supplied Keyword: Complete heart block; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Ventricular heart rate.; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1469-8986.ep12320900
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ALEXANDER, ELAINE L.
AU - WETZEL, BRUCE
T1 - Human Lymphocytes: Similarity of B and T Cell Surface Morphology.
JO - Science
JF - Science
Y1 - 1975/05/16/
VL - 188
IS - 4189
M3 - Article
SP - 732
EP - 734
SN - 00368075
AB - When viewed by scanning electron microscopy, human lymphocytes fixed in suspension and processed with minimal cell loss appear uniformly cover with short microvilli. Contrary to previous reports, lymphocytes from subpopulatiot riched for T cells are villous and indistinguishable from B lymphocytes. Whereas lymphocyte surface architecture can change rapidly and substantially in response to environmental moditfications, such as contact with an underlying surface, these alterations are similar for both B and T cells and do not serve to distinguish these subpopulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85118989; ALEXANDER, ELAINE L. 1; WETZEL, BRUCE 2; Affiliations: 1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Dermatology Branch, National Cancer Institute; Issue Info: 5/16/1975, Vol. 188 Issue 4189, p732; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gillespie, David
AU - Gallo, Robert C.
T1 - RNA Processing and RNA Tumor Virus Origin and Evolution.
JO - Science
JF - Science
Y1 - 1975/05/23/
VL - 188
IS - 4190
M3 - Article
SP - 802
EP - 811
SN - 00368075
N1 - Accession Number: 85119001; Gillespie, David 1; Gallo, Robert C.; Affiliations: 1: senior investigator, chief of Laboratory, Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/23/1975, Vol. 188 Issue 4190, p802; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Nathanson, J. A.;
AU - Bloom, F. E.;
T1 - Lead-induced inhibition of brain adenyl cyclase
CT - Lead-induced inhibition of brain adenyl cyclase
JO - Nature (London)
JF - Nature (London)
Y1 - 1975/05/29/
VL - 255
IS - May 29
SP - 419
EP - 420
AD - Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeth's Hospital, Washington, D.C. 20032
N1 - Accession Number: 13-0938; Language: English; Chemical Name: Lead--7439-92-1; References: 23; Publication Type: Letters; Journal Coden: NATUAS; Section Heading: Toxicity; Pharmacology; Abstract Author: William H. Jeffery
N2 - It was found that very low concentrations of lead inhibit adenyl cyclase activity in rat brain tissue, but no biochemical basis could be clearly established for the behavioral defects associated with chronic lead toxicity.
KW - Lead--toxicity-;
KW - Toxicity--lead--behavioral defects, lack of biochemical basis, in rats;
KW - Poisoning--lead--behavioral defects, lack of biochemical basis, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Pearlin, Leonard I.
T1 - STATUS INEQUALITY AND STRESS IN MARRIAGE.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1975/06//
VL - 40
IS - 3
M3 - Article
SP - 344
EP - 357
SN - 00031224
AB - Emotional stresses that are experienced In marriage are traced to difference: in spouses' status origins, Linking status differences to such stress are a number of Intervening conditions. People to whom status advancement is important and who have married mates of lower status are apt to have a sense of loss that leads, us turn, to a disruption of reciprocity, expressiveness, affection and value sharing In marital exchange. Such disruptions then act as immediate antecedents to emotional stress. It is through this process that the status order of the larger society can reach out to have a deleterious influence on the emotional states arising out of marital transactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RECIPROCITY (Commerce)
KW - STRESS (Psychology)
KW - MARRIAGE
KW - MARRIED people
KW - FRIENDSHIP
KW - MENTAL health
N1 - Accession Number: 14894355; Pearlin, Leonard I. 1; Affiliations: 1: Laboratory of Socio-Environmental Studies, National Institute of Mental Health.; Issue Info: Jun75, Vol. 40 Issue 3, p344; Thesaurus Term: RECIPROCITY (Commerce); Subject Term: STRESS (Psychology); Subject Term: MARRIAGE; Subject Term: MARRIED people; Subject Term: FRIENDSHIP; Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Layard, M. W. J.
T1 - The Generalized Jackknife Statistic (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1975/06//
VL - 70
IS - 350
M3 - Book Review
SP - 486
SN - 01621459
AB - Reviews the book "The Generalized Jackknife Statistic," by H.L. Gray and W.R. Sehucany.
KW - STATISTICS
KW - JACKKNIFE (Statistics)
KW - NONFICTION
KW - GRAY, H. L.
KW - SCHUCANY, W. R.
KW - SEHUCANY, W. R.
KW - GENERALIZED Jackknife Statistic, The (Book)
N1 - Accession Number: 4604431; Layard, M. W. J. 1; Affiliations: 1: National Cancer Institute.; Issue Info: Jun75, Vol. 70 Issue 350, p486; Thesaurus Term: STATISTICS; Subject Term: JACKKNIFE (Statistics); Subject Term: NONFICTION; Reviews & Products: GENERALIZED Jackknife Statistic, The (Book); People: GRAY, H. L.; People: SCHUCANY, W. R.; People: SEHUCANY, W. R.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Berg, Paul
AU - Baltimore, David
AU - Brenner, Sydney
AU - Roblin III, Richard O.
AU - Singer, Maxine F.
T1 - Asilomar Conference on Recombinant DNA Molecules.
JO - Science
JF - Science
Y1 - 1975/06/06/
VL - 188
IS - 4192
M3 - Article
SP - 991
EP - 994
SN - 00368075
N1 - Accession Number: 85119090; Berg, Paul 1; Baltimore, David 2; Brenner, Sydney 3; Roblin III, Richard O. 4; Singer, Maxine F. 5; Affiliations: 1: Professor of biochemistry, Department of Biochemistry, Stanford University Medical Center, Stanford, California; 2: American Cancer Society Professor of Microbiology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; 3: Member of Scientific Staff of Medical Research Council of United Kingdom, Cambridge, England; 4: Professor of microbiology and molecular genetics, Harvard Medical School, and assistant bacteriologist, Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts; 5: Head of Nucleic Acid Enzymology Section, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Issue Info: 6/ 6/1975, Vol. 188 Issue 4192, p991; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOODMAN, DAVID B. P.
AU - BLOOM, FLOYD E.
AU - BATTENBERG, ELLENA R.
AU - RASMUSSEN, HOWARD
AU - DAVIS, WALTER L.
T1 - Immunofluorescent Localization of Cyclic AMP in Toad Urinary Bladder: Possible Intercellular Transfer.
JO - Science
JF - Science
Y1 - 1975/06/06/
VL - 188
IS - 4192
M3 - Article
SP - 1023
EP - 1025
SN - 00368075
AB - By use of an immunofluorescent cytochemical staining technique, adenosine 3',5'-monophosphate (cyclic A MP) has been localized in toad bladder epithelial cells. Within 2 minutes after addition of vasopressin, staining intensity increases in both mitochondria-rich and granular cells. This finding, taken together with the precise anatomieal relation between these two epithelial cell types and the observation that after separation of the two cell types vasopressin stimulates cyclic AMP accumulation in only mitochondria-rich cells, suggests that cyclic AMP may be transferred from mitochrondria-rich to granular cells as part of the response of the toad urinary bladder to vasopressin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85119117; GOODMAN, DAVID B. P. 1; BLOOM, FLOYD E. 2; BATTENBERG, ELLENA R. 2; RASMUSSEN, HOWARD 3; DAVIS, WALTER L. 4; Affiliations: 1: Departments of Pediatrics and Biochemistry, University of Pennsylvania Medical School, Philadelphia 19174; 2: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 3: Departments of Pediatrics and Biochemistry, University of Pennsylvania Medical School; 4: Department of Pathology, Baylor University Medical Center, Dallas, Texas 75226; Issue Info: 6/ 6/1975, Vol. 188 Issue 4192, p1023; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Canellos, G. P.;
T1 - Second malignancies complicating Hodgkin's disease in remission
CT - Second malignancies complicating Hodgkin's disease in remission
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1975/06/07/
VL - 1
IS - Jun 7
SP - 1294
SN - 00237507
AD - National Institutes of Health, National Cancer Institute, Medicine Branch, Bethesda, Maryland 20014
N1 - Accession Number: 12-6364; Language: English; Trade Name: Nitrogen mustard; Generic Name: Mechlorethamine; Chemical Name: Mechlorethamine--51-75-2 Prednisone--53-03-2 Procarbazine--671-16-9 Vincristine--57-22-7; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2 - Two cases of leukemia are reported in patients who were being treated for Hodgkin's disease with extensive radiotherapy and chemotherapy, including the MOPP regimen (nitrogen mustard (mechlorethamine), vincristine, procarbazine and prednisone).
KW - Mechlorethamine--prednisone, procarbazine and vincristine-;
KW - Prednisone--mechlorethamine, procarbazine and vincristine-;
KW - Procarbazine--mechlorethamine, prednisone and vincristine-;
KW - Vincristine--mechlorethamine, prednisone and procarbazine-;
KW - Drugs, adverse reactions--mechlorethamine, prednisone, procarbazine and vincristine--leukemias, in Hodgkin's disease patients;
KW - Drugs, adverse reactions--prednisone, mechlorethamine, procarbazine and vincristine--leukemias, in Hodgkin's disease patients;
KW - Drugs, adverse reactions--procarbazine, mechlorethamine, prednisone and vincristine--leukemias, in Hodgkin's disease patients;
KW - Drugs, adverse reactions--vincristine, mechlorethamine, prednisone and procarbazine--leukemias, in Hodgkin's disease patients;
KW - Combined therapy--antineoplastic agents--adverse reactions, leukemia, in Hodgkin's disease patients;
KW - Antineoplastic agents--combined therapy--adverse reactions, leukemia, in Hodgkin's disease patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - VARMA, S. D.
AU - MIKUNI, I.
AU - KINOSHITA, J. H.
T1 - Flavonoids as Inhibitors of Lens Aldose Reductase.
JO - Science
JF - Science
Y1 - 1975/06/20/
VL - 188
IS - 4194
M3 - Article
SP - 1215
EP - 1216
SN - 00368075
AB - Flavonoids are effective inhibitors oftens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136203; VARMA, S. D. 1; MIKUNI, I. 1; KINOSHITA, J. H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; Issue Info: 6/20/1975, Vol. 188 Issue 4194, p1215; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - OKA, TAKAMI
AU - TOPPER, YALE J.
T1 - Insulin-Unresponsive Tissues Respond To Superactive Insulin-Like Material.
JO - Science
JF - Science
Y1 - 1975/06/27/
VL - 188
IS - 4195
M3 - Article
SP - 1317
EP - 1319
SN - 00368075
AB - Insulin-like material prepared frprn +insu/in-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bij6J objob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-/ ike material and insulin are equipotent on the corresponding tissues from lean littermates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136243; OKA, TAKAMI 1; TOPPER, YALE J. 1; Affiliations: 1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 6/27/1975, Vol. 188 Issue 4195, p1317; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Patel, A. R.;
AU - Gori, G. B.;
T1 - Preparation and monitoring of marihuana smoke condensate samples
CT - Preparation and monitoring of marihuana smoke condensate samples
JO - Bulletin on Narcotics (USA)
JF - Bulletin on Narcotics (USA)
Y1 - 1975/07/01/
VL - 27
IS - Jul-Sep
SP - 47
EP - 54
SN - 0007523X
AD - Meloy Laboratories, Inc., Springfield, Virginia 22151) (Reprints: National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 14-0637; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Cannabis--8063-14-7; References: 13; Journal Coden: BNUNA5; Section Heading: Pharmaceutical Technology; Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The preparation of standard marihuana (cannabis) cigarettes 85 mm long and 25 mm in circumference using medium porosity paper, with no filter, and the production and gas chromatographic analysis of smoke condensate samples is described.
KW - Cannabis--standards-;
KW - Standards--cannabis--cigarettes, production and GLC analysis;
KW - Cigarettes--cannabis--standards, production and GLC analysis;
KW - Chromatography, gas--cannabis--cigarettes, and standards;
KW - Manufacturing--cannabis--cigarettes, standards and GLC analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Flamm, W. G.;
T1 - Test systems for assessing mutagenic potential of chemical substances
CT - Test systems for assessing mutagenic potential of chemical substances
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/07/01/
VL - 58
IS - Jul
SP - 668
EP - 671
AD - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-0222; Language: English; References: 9; Journal Coden: JANCA2; Section Heading: Methodology; Abstract Author: Douglas L. Thompson
N2 - Bacterial and animal test systems that can be used for the detection and evaluation of mutagenic substances are briefly discussed.
KW - Toxicity--methodology--mutagens, test systems;
KW - Mutagens--methodology--tests, bacterial and animal;
KW - Chemicals--mutagens--tests, bacterial and animal;
KW - Methodology--toxicity--mutagens, bacterial and animal test systems;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ugel, Arthur R.
T1 - BOVINE KERATOHYALIN: ANATOMICAL, HISTOCHEMICAL, ULTRASTRUCTURAL, IMMUNOLOGIC, AND BIOCHEMICAL STUDIES.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/07//
VL - 65
IS - 1
M3 - Article
SP - 118
EP - 126
SN - 0022202X
AB - Salt extraction studies showed that keratohyalin (KH) could be solubilized and extracted from fresh bovine hoof epidermis. The solubility of KH varied in relation to the molarity of the salt solution used for extraction. Using this information, the extracted KH was aggregated in vitro by dialyzing the high salt extract against distilled water. Histochemical, ultrastructural, and immunologic studies of the resultant particles or macroaggregates showed that the latter had the same properties and immunogenicity as the KH granule in situ and produced antibodies against it. Fractionation of the macroaggregates by polyacrylamide gel electrophoresis demonstrated that the macroaggregates were composed of sets of 20 polymers whose subunits or monomers had a molecular weight of 16,900. Amino acid analyses showed that the macroaggregates and the various fractionated polymers were similar and that the protein had 116 amino acid residues. Serine, arginine, glycine, glutamic acid, and histidine constituted 78% of all residues, and serine alone represented 27%. The molecular weight by amino acid analyses was 16,150 after correction for the 8% ribonucleic acid which appears to he complexed to the protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - POLYACRYLAMIDE
KW - GLUTAMIC acid
KW - HISTOCHEMISTRY
KW - IMMUNOLOGY
KW - ULTRASTRUCTURE (Biology)
N1 - Accession Number: 12598085; Ugel, Arthur R. 1; Affiliation: 1: Dermatology Branch, National Cancer institute, National Institutes of Health, Bethesda, Maryland; Source Info: Jul75, Vol. 65 Issue 1, p118; Subject Term: AMINO acids; Subject Term: POLYACRYLAMIDE; Subject Term: GLUTAMIC acid; Subject Term: HISTOCHEMISTRY; Subject Term: IMMUNOLOGY; Subject Term: ULTRASTRUCTURE (Biology); Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1523-1747.ep12598085
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Mulvihill, J. J.;
AU - Ridolfi, R. L.;
AU - Schultz, F. R.;
AU - Borzy, M. S.;
AU - Haughton, P. B. T.;
T1 - Hepatic adenoma in Fanconi anemia treated with oxymetholone
CT - Hepatic adenoma in Fanconi anemia treated with oxymetholone
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1975/07/01/
VL - 87
IS - Jul
SP - 122
EP - 124
SN - 00223476
AD - A-521 Landow Bldg., National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-0348; Language: English; Chemical Name: Oxymetholone--434-07-1; References: 16; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Charles D. Ponte
N2 - A case report is presented of oxymetholone (I) and prednisone (II) therapy in a 13-year-old white male who, at age 8.5 years, was diagnosed as having Fanconi pancytopenia. I, 20-60 mg/day, was initiated in combination with II. The patient showed clinical improvement for 15 months following therapy. Five months prior to his death, hyperbilirubinemia (23 mg/dl) and liver function abnormalities occurred. Two weeks later the patient died from intracranial hemorrhage and pseudomonas sepsis. A single hepatic adenoma was observed at autopsy. The possible causual relationship between androgenic therapy and hepatic tumors is cited, as evidenced by previous reports. However, the primary etiological relationships are as yet unknown. Hepatic adenomas appear to be nonmalignant; yet there should be cause for concern depending on size, location, and other factors. Angiography is recommended as an aid to diagnosis except where thrombocytopenia exists. When a diagnosis is made stoppage of the androgenic steroids is favored over surgery or radiation therapy.
KW - Oxymetholone--contraindications-;
KW - Toxicity--oxymetholone--anemias, Fanconi, fatal, in child;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yeh, S. Y.;
AU - McQuinn, R. L.;
T1 - GLC determination of heroin and its metabolites in human urine
CT - GLC determination of heroin and its metabolites in human urine
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/07/01/
VL - 64
IS - Jul
SP - 1237
EP - 1239
SN - 00223549
AD - Div. of Research, Addiction Research Center, National Institute on Drug Abuse, Lexington, Kentucky 40511
N1 - Accession Number: 13-1764; Language: English; Trade Name: Heroin; Generic Name: Diacetylmorphine; Chemical Name: Diacetylmorphine--561-27-3 Morphine--57-27-2 Normorphine--466-97-7; References: 16; Publication Type: Notes; Journal Coden: JPMSAE; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2 - Heroin (diacetylmorphine) and its metabolites, 6-monoacetylmorphine, morphine, and normorphine, were determined in human urine with a gas-liquid chromatographic procedure.
KW - Diacetylmorphine--and metabolites-;
KW - 6-Monoacetylmorphine--excretion-;
KW - Morphine--excretion-;
KW - Normorphine--excretion-;
KW - Chromatography, gas--diacetylmorphine--and metabolites, urinary excretion, in humans;
KW - Excretion--diacetylmorphine--and metabolites, urinary, GLC, in humans;
KW - Metabolism--diacetylmorphine--and metabolites, urinary excretion, GLC, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Williams Jr, Redford B.
AU - Bittker, Thomas E.
AU - Buchsbaum, Monte S.
AU - Wynne, Lyman C.
T1 - Cardiovascular and Neurophysiologic Correlates of Sensory Intake and Rejection. I. Effect of Cognitive Tasks.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1975/07//
VL - 12
IS - 4
M3 - Article
SP - 427
EP - 433
SN - 00485772
AB - In this study of the relationship between sensory processing and cardiovascular function, five cardiovascular parameters were monitored during baseline periods and during tasks requiring either sensory intake or sensory rejection behavior on the part of 19 subjects. Sensory intake behavior was associated with a pattern of response similar to that seen with activation of peripheral sympathetic nerves--vasoconstriction in both the digit (skin) and forearm (skeletal muscle). In contrast, sensory rejection behavior was associated with vasodilation in the forearm and vasoconstriction in the digit. Individual differences is an EEG measure of characteristic ways of processing sensory information were predictably associated with differences in resting cardiovascular function. The association of sensory intake with a skeletal muscle vasoconstriction may help to extend our understanding of the physiology of sensory processing, since heretofore only heart rate and somatic motor activity have reliably differentiated sensory intake from sensory rejection behavior. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR system
KW - BLOOD circulation
KW - NEUROPHYSIOLOGIC monitoring
KW - SENSORY neurons
KW - SKIN diseases
KW - HEART beat
KW - INDIVIDUAL differences
KW - Augmenting and reducing of average evoked responses.
KW - Forearm blood flow and vascular resistance
KW - Individual differences
KW - Sensory processing (intake and rejection)
N1 - Accession Number: 11685277; Williams Jr, Redford B. 1 Bittker, Thomas E. 1,2 Buchsbaum, Monte S. 1 Wynne, Lyman C. 1,3; Affiliation: 1: Laboratory of Clinical Psychobiology and Adult Psychiatry Branch, National Institute of Mental Health, Bethesda. 2: Arizona Health Plan, Phoenix, Arizona. 3: Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York.; Source Info: Jul1975, Vol. 12 Issue 4, p427; Subject Term: CARDIOVASCULAR system; Subject Term: BLOOD circulation; Subject Term: NEUROPHYSIOLOGIC monitoring; Subject Term: SENSORY neurons; Subject Term: SKIN diseases; Subject Term: HEART beat; Subject Term: INDIVIDUAL differences; Author-Supplied Keyword: Augmenting and reducing of average evoked responses.; Author-Supplied Keyword: Forearm blood flow and vascular resistance; Author-Supplied Keyword: Individual differences; Author-Supplied Keyword: Sensory processing (intake and rejection); Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1469-8986.ep11685277
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bittker, Thomas E.
AU - Buchsbaum, Monte S.
AU - Williams Jr., Redford B.
AU - Wynne, Lyman C.
T1 - Cardiovascular and Neurophysiologic Correlates of Sensory Intake and Rejection. II. Interview Behavior.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1975/07//
VL - 12
IS - 4
M3 - Article
SP - 434
EP - 438
SN - 00485772
AB - As part of a three task study of the influence of attentional style on cardiovascular response, 19 normal volunteers were given a 15-min interview during which systolic and diastolic blood pressure, digital pulse volume, heart rate, and forearm blood flow were recorded. At the same time two observers independently assessed five elements of the subjects' interview behavior; arousal, eye contact with the interviewer, self-revelation of interview center, attentiveness to the interviewer, and overall transactional engagement in the interview task. When subjects were divided into groups of interview attenders and nonattenders on the basis of interviewer ratings, attenders had a mean decrease in forearm blood flow and nonattenders a mean increase. These group differences extended across a word identification (sensory intake) and mental arithmetic (sensory rejection) task a well. When subjects were divided into groups of forearm blood flow increasers and decreasers, increasers displayed less attentiveness to the interviewer, less self-revelation, greater arousal, and less transactional engagement than did decreases (N=9). Attentiveness to the interviewer and transactional engagement were the two most sensitive behavioral discriminators in comparing the increaser and decreaser groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR system
KW - NEUROPHYSIOLOGIC monitoring
KW - SENSORY neurons
KW - BLOOD pressure
KW - HEART beat
KW - NEUROPHYSIOLOGY
KW - Attention.
KW - Cardiovascular response
KW - Interview behavior
KW - Sensory intake and rejection
N1 - Accession Number: 11685290; Bittker, Thomas E. 1 Buchsbaum, Monte S. 1 Williams Jr., Redford B. 1 Wynne, Lyman C. 1; Affiliation: 1: Adult Psychiatry Branch and Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda.; Source Info: Jul1975, Vol. 12 Issue 4, p434; Subject Term: CARDIOVASCULAR system; Subject Term: NEUROPHYSIOLOGIC monitoring; Subject Term: SENSORY neurons; Subject Term: BLOOD pressure; Subject Term: HEART beat; Subject Term: NEUROPHYSIOLOGY; Author-Supplied Keyword: Attention.; Author-Supplied Keyword: Cardiovascular response; Author-Supplied Keyword: Interview behavior; Author-Supplied Keyword: Sensory intake and rejection; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1469-8986.ep11685290
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Westergaard, J.
AU - Nylen, M. U.
T1 - Dose and age dependent variations in effect of tetracycline on enamel formation in rat.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1975/07//
VL - 83
IS - 4
M3 - Article
SP - 209
EP - 232
SN - 0029845X
AB - Incidence of rats with gross enamel lesions in response to tetracycline hydrochloride (TC) was studied in relationship to age, tooth type, and concentration of antibiotic in the injection fluid. Incidence was defined as percentage of animals with defects in at least one incisor or one molar. Serum levels were measured at various intervals in 4- and 75-day-old rats, which received a single i.p. injection with 130 mg/kg bw in concentrations of either 13 or 25 mg/ml saline. The study confirmed that the effect of TC on enamel varied with age of the animal and that the molar responded more readily than the incisor. Furthermore, the incidence was higher the higher the concentration of antibiotic. This effect appeared tied to a direct relationship between concentration and serum level. Serum levels declined more slowly in the younger than in the older rats, resulting in significantly higher levels 6, 24 and 48 h after dosing, which correlated with a more extensive labeling of the dentin in the young rats. The possible roles of serum levels, capillary supply and cell susceptibility are discussed in relation to differences in response with animal age, between tooth types, tooth surfaces and with age of the secretory cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACYCLINE
KW - DENTAL enamel
KW - RATS as laboratory animals
KW - DENTISTRY
KW - ANTIBIOTICS
KW - DENTAL therapeutics
KW - dental enamel
KW - drugs
KW - histology
KW - microradiography
KW - rat
KW - spectrophotofluorometry
KW - tetracyclines
N1 - Accession Number: 13209265; Westergaard, J. 1 Nylen, M. U. 1; Affiliation: 1: Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Md., U.S.A.; Source Info: 1975, Vol. 83 Issue 4, p209; Subject Term: TETRACYCLINE; Subject Term: DENTAL enamel; Subject Term: RATS as laboratory animals; Subject Term: DENTISTRY; Subject Term: ANTIBIOTICS; Subject Term: DENTAL therapeutics; Author-Supplied Keyword: dental enamel; Author-Supplied Keyword: drugs; Author-Supplied Keyword: histology; Author-Supplied Keyword: microradiography; Author-Supplied Keyword: rat; Author-Supplied Keyword: spectrophotofluorometry; Author-Supplied Keyword: tetracyclines; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wiener, Jack
T1 - Schizophrenics in the New Custodial Community: Five Years After the Experiment (Book).
JO - Social Work
JF - Social Work
Y1 - 1975/07//
VL - 20
IS - 4
M3 - Book Review
SP - 332
EP - 333
PB - Oxford University Press / USA
SN - 00378046
AB - Reviews the book "Schizophrenics in the New Custodial Community: Five Years After the Experiment," by Ann E. Davis, Simon Dinitz and Benjamin Pasamanick.
KW - SCHIZOPHRENICS
KW - NONFICTION
KW - DAVIS, Ann E.
KW - DINITZ, Simon
KW - PASAMANICK, Benjamin
KW - SCHIZOPHRENICS in the New Custodial Community: Five Years After the Experiment (Book)
N1 - Accession Number: 5267277; Wiener, Jack 1; Affiliation: 1: National Institute of Mental Health, Rockville, Maryland; Source Info: Jul75, Vol. 20 Issue 4, p332; Subject Term: SCHIZOPHRENICS; Subject Term: NONFICTION; Reviews & Products: SCHIZOPHRENICS in the New Custodial Community: Five Years After the Experiment (Book); People: DAVIS, Ann E.; People: DINITZ, Simon; People: PASAMANICK, Benjamin; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rauscher Jr., Frank J.
T1 - Research and the National Cancer Program.
JO - Science
JF - Science
Y1 - 1975/07/11/
VL - 189
IS - 4197
M3 - Article
SP - 115
EP - 119
SN - 00368075
N1 - Accession Number: 85136294; Rauscher Jr., Frank J. 1; Affiliations: 1: Director, National Cancer Program, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: 7/11/1975, Vol. 189 Issue 4197, p115; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NELSON, RALPH
AU - LCTZOW, ASTRID V.
AU - KOLB, HELGA
AU - GOURAS, PETER
T1 - Horizontal Cells in Cat Retina with Independent Dendritic Systems.
JO - Science
JF - Science
Y1 - 1975/07/11/
VL - 189
IS - 4197
M3 - Article
SP - 137
EP - 139
SN - 00368075
AB - Cat horizontal cells are retinal neurons with two functionally distinct parts; the cell body receives signals predominantly from cones, while the terminal arborization receives predominantly from rods. The long thin process connecting these parts neither generates impulses nor allows significant passive electrotonic conduction between them. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136313; NELSON, RALPH 1; LCTZOW, ASTRID V. 2; KOLB, HELGA 3; GOURAS, PETER 4; Affiliations: 1: Neurophysiology Section, Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Institu für Allgemeine und Vergleichende Physiologie der Universitiät Wien, Schwarzspanierstrasse 17, 1090 Vienna, Austria; 3: Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014; 4: Neurophysiology Section, Laboratory of Vision Research, National Eye Institute; Issue Info: 7/11/1975, Vol. 189 Issue 4197, p137; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GIMBRONE JR., MICHAEL A.
AU - ALEXANDER, R. WAYNE
T1 - Angiotensin 11 Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium.
JO - Science
JF - Science
Y1 - 1975/07/18/
VL - 189
IS - 4198
M3 - Article
SP - 219
EP - 220
SN - 00368075
AB - Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Production is inhibited by indomethacin and stimulated by angiotensin I. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136343; GIMBRONE JR., MICHAEL A. 1; ALEXANDER, R. WAYNE 2; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Hypertension-Endocrine Branch, National Heart and Lung Institute, Bethesda, Maryland 20014; Issue Info: 7/18/1975, Vol. 189 Issue 4198, p219; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Gimbrone, M. A.;
AU - Alexander, R. W.;
T1 - Angiotension II stimulation of prostaglandin production in cultured human vascular endothelium
CT - Angiotension II stimulation of prostaglandin production in cultured human vascular endothelium
JO - Science
JF - Science
Y1 - 1975/07/18/
VL - 189
IS - Jul 18
SP - 219
EP - 220
AD - Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014 and Hypertension-Endocrine Branch, National Heart and Lung Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-0440; Language: English; Chemical Name: Angiotensin II--11128-99-7; References: 12; Journal Coden: SCIEAS; Section Heading: Pharmacology; Abstract Author: Larry N. Gever
N2 - Vasoactive octapeptide angiotensin II stimulates production of an immunoreactive prostaglandin E(I)-like material. Angiotensin II appears to act by increasing the de novo synthesis of I, rather than its passive release. By isolating homogeneous populations of human vasculature endothelium in culture, this cell type has been identified as a potential source of I secretion in response to angiotensin II. The production of this immunoreactive material is inhibited by indomethacin. Pathophysiologic factors that modulate secretion of I by the endothelial cell may be important in the local control of vascular tone, permeability, and platelet-dependent thrombotic phenomena.
KW - Angiotensin II--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ANSLOW, RALPH O.
AU - EWALD, BRUCE H.
AU - PAKES, STEVEN P.
AU - SMALL, J. DAVID
AU - WHITNEY JR., ROBERT A.
T1 - Control of Infectious Diseases among Rodent Stocks.
JO - Science
JF - Science
Y1 - 1975/07/25/
VL - 189
IS - 4199
M3 - Article
SP - 248
EP - 248
SN - 00368075
N1 - Accession Number: 88002689; ANSLOW, RALPH O. 1; EWALD, BRUCE H. 2; PAKES, STEVEN P. 3; SMALL, J. DAVID 4; WHITNEY JR., ROBERT A. 4; Affiliations: 1: Research Animal Resources Center, University of Wisconsin, Madison 53705; 2: Department of Laboratory Animal Medicine, Cornell University Medical College, New York 10021; 3: Animal Resources Center, University of Texas Southwestern Medical School, Dallas 75235; 4: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 7/25/1975, Vol. 189 Issue 4199, p248; Number of Pages: 2/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Blot, W. J.;
AU - Fraumeni, J. F.;
T1 - Arsenical air pollution and lung cancer
CT - Arsenical air pollution and lung cancer
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1975/07/26/
VL - 2
IS - Jul 26
SP - 142
EP - 144
SN - 00237507
AD - National Cancer Institute, A521 Landow Bldg., Bethesda, Maryland 20014
N1 - Accession Number: 13-0229; Language: English; Chemical Name: Arsenic--7440-38-2; References: 15; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - Average mortality rates from lung cancer for White males and females in the U.S.A. for the period 1950-69 were significantly increased in counties with copper, lead, or zinc smelting and refining industries, but not in counties where other non-ferrous ores are processed. The excess mortality was not attributed to differences in geographic region, population density, urbanization, socioeconomic status, or other manufacturing processes. The findings suggest the influence of community air pollution from industrial emissions containing inorganic arsenic.
KW - Arsenic--toxicity, environmental-;
KW - Toxicity, environmental--arsenic--effects, industrial emissions, in humans;
KW - Industry--arsenic--toxicity, environmental, emissions, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Padilla, Elena
AU - Goldston, Stephen E.
T1 - Profiles of Physicians Trained in Schools of Public Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1975/08//
VL - 65
IS - 8
M3 - Article
SP - 828
EP - 836
PB - American Public Health Association
SN - 00900036
AB - The physician who graduates from a school of public health differs in many respects from a private practitioner. A profile of public health physicians is presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health personnel
KW - PUBLIC health schools
KW - PHYSICIANS
KW - MEDICAL personnel
KW - MEDICAL education
KW - PUBLIC health
KW - MEDICAL care
KW - INTERNSHIP programs
KW - EMPLOYEE training
N1 - Accession Number: 5701272; Padilla, Elena 1 Goldston, Stephen E. 2; Affiliation: 1: Professor and Director, Health Planning, Policy, and Administration, Graduate School of Public Administration, New York University, New York, New York 2: Coordinator for Primary Prevention Programs, Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, Maryland 20852; Source Info: Aug1975, Vol. 65 Issue 8, p828; Subject Term: PUBLIC health personnel; Subject Term: PUBLIC health schools; Subject Term: PHYSICIANS; Subject Term: MEDICAL personnel; Subject Term: MEDICAL education; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: INTERNSHIP programs; Subject Term: EMPLOYEE training; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Carenzi, A.;
AU - Gillin, J. C.;
AU - Guidotti, A.;
AU - Schwartz, M. A.;
AU - Wyatt, R. J.;
AU - \ET/;
T1 - Dopamine-sensitive adenylyl cyclase in human caudate nucleus
CT - Dopamine-sensitive adenylyl cyclase in human caudate nucleus
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/08/01/
VL - 32
IS - Aug
SP - 1056
EP - 1059
AD - National Institute of Mental Health, St. Elizabeths Hospital, WAW Building, Washington, D.C. 20032
N1 - Accession Number: 13-3252; Language: English; Trade Name: Intropin--Norepinephrine--Levophed--Haldol; Generic Name: Dopamine; Levarterenol; Levarterenol; Haloperidol; Chemical Name: Dopamine--51-61-6 Haloperidol--52-86-8; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents dopamine (12:12); AHFS Class: Sympathomimetic agents levarterenol (28:16.08); AHFS Class: Tranquilizers haloperidol; References: 11; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Low concentrations of dopamine (Intropin), stimulated striatal adenylyl cyclase activity from 16 autopsied human brains. Norepinephrine (levarterenol; Levophed) was about one-third as potent and histamine and serotonin were ineffective. Haloperidol (Haldol) inhibited dopamine's stimulatory activity on adenylyl cyclase. No difference in the level and activity of basal adenylyl cyclase in 9 control subjects and 7 chronic schizophrenics occurred after dopamine stimulation.
KW - Dopamine--effects-;
KW - Levarterenol--effects-;
KW - Haloperidol--effects-;
KW - Sympathomimetic agents--dopamine--effects, striatal adenylyl cyclase activity, in human brain tissue;
KW - Sympathomimetic agents--levarterenol--effects, striatal adenylyl cyclase activity, in human brain tissue;
KW - Tranquilizers--haloperidol--effects, dopamine stimulated striatal adenylyl cyclase activity, in human brain tissue;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Post, R. M.;
AU - Fink, E.;
AU - Carpenter, W. T.;
AU - Goodwin, F. K.;
T1 - Cerebrospinal fluid amine metabolites in acute schizophrenia
CT - Cerebrospinal fluid amine metabolites in acute schizophrenia
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/08/01/
VL - 32
IS - Aug
SP - 1063
EP - 1069
AD - Section on Psychobiology, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm 3S 239, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 13-3705; Language: English; Trade Name: Benemid; Generic Name: Probenecid; Chemical Name: Probenecid--57-66-9; References: 94; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Probenecid (Benemid), 100 mg/kg/day in divided doses, was used in the study of homovanillic acid (I) cerebrospinal fluid levels in 20 schizophrenic patients 16-54 yr old. The use of this drug allowed I and 5-hydroxyindole acetic acid (II) to accumulate in the CSF. No alteration in central serotonin or norepinephrine metabolism was apparent following I and II accumulation.
KW - Probenecid--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carter, S. K.;
AU - Wasserman, T. H.;
T1 - Chemotherapy of urologic cancer
CT - Chemotherapy of urologic cancer
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1975/08/01/
VL - 36
IS - Aug (Suppl)
SP - 729
EP - 747
AD - Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-3251; Language: English; References: 110; Publication Type: Review; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - The review of the status of evaluation of chemotherapeutic agents in the urologic malignancies reveals a largely neglected area of investigation. Except for testicular carcinomas, which are highly responsive to drug therapy, active agents have not been clearly established for the other urogenital tumor sites. Published information and data on file in the Cancer Therapy Evaluation Program of the NCI are reviewed, and studies currently in progress are outlined. Adequate clinical testing of the standard antitumor agents that are active against other human malignancies should receive high priority in future therapeutic trials in urologic cancer.
KW - Antineoplastic agents--cancer--urologic, therapy, in patients;
KW - Research--antineoplastic agents--urologic, review;
KW - Methodology--antineoplastic agents--research, urologic cancer, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Macdonald, J. S.
AU - Wundereich, J. R.
AU - Yust, L.
AU - Yankee, R. N.
T1 - COMPLEMENT-DEPENDENT AND CELL-DEPENDENT ANTIPLATELET HUMORAL ANTIBODY IN SERA FROM MULTI-TRANSFUSED PATIENTS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/08//
VL - 21
IS - 2
M3 - Article
SP - 259
EP - 266
PB - Wiley-Blackwell
SN - 00099104
AB - Sera from eight multi-transfused patients, who were resistant to platelet transfusions from allogeneic donors, were tested for antiplatelet humoral antibody. Complement-dependent cytotoxic humoral antibody against platelets was found in sera from six of eight patients. Cell-dependent cytotoxic humoral antibody against platelets was found in sera from four of seven of these patients. Sera from two patients had cell-dependent antiplatelet activity but no detectable complement-dependent and cell-dependent humoral immunity may be important pathways for in viro resistance to platelets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelets
KW - IMMUNOGLOBULINS
KW - BLOOD plasma
KW - PATIENTS
KW - IMMUNITY
KW - PLASMA cells
N1 - Accession Number: 16021795; Macdonald, J. S. 1 Wundereich, J. R. 2 Yust, L. 3 Yankee, R. N. 4; Affiliation: 1: Department of Medicine, Georgetown University, Medical Centre, 3800 Reservoir Road, Washington, D.C. 20007, U.S.A. 2: Immunology Branch and Pediatric Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A. 3: Children's Cancer Research Foundation, 35 Binney Street, Boston, Massachusetts 02115, U.S.A. 4: Department of Medicine, B. Ichilov Hospital, Tel Aviv, Israel; Source Info: Aug1975, Vol. 21 Issue 2, p259; Subject Term: BLOOD platelets; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD plasma; Subject Term: PATIENTS; Subject Term: IMMUNITY; Subject Term: PLASMA cells; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lutzner, Marvin A.
AU - Hansen, Carl T.
T1 - SKIN BLISTERS AND HAIR LOSS IN A RAT MUTANT CALLED VIBRISSAELESS (vb).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/08//
VL - 65
IS - 2
M3 - Article
SP - 212
EP - 216
SN - 0022202X
AB - A radiation-induced autosomal recessive mutant in the rat called vibrissaeless (vb), has been described and studied. Mutants have abnormal hair growth, the hairs being reduced in number and length. Mutant animals form blisters which then erode, crust, and heal without scars. The blisters can be artificially produced by friction and result from intraepidermal separation which is suprabasilar in position. To date, we cannot correlate this abnormality in rats with any known inherited human blistering disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLISTERS
KW - SKIN diseases
KW - SCARS
KW - GRANULATION tissue
KW - RATS
N1 - Accession Number: 12598215; Lutzner, Marvin A. 1 Hansen, Carl T. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland.; Source Info: Aug75, Vol. 65 Issue 2, p212; Subject Term: BLISTERS; Subject Term: SKIN diseases; Subject Term: SCARS; Subject Term: GRANULATION tissue; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12598215
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Carter, S. K.;
AU - Kershner, L. M.;
T1 - What you should know about drugs vs. cancer
CT - What you should know about drugs vs. cancer
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1975/08/01/
VL - 41
IS - Aug
SP - 56
EP - 66
SN - 00030627
AD - National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-2057; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Walter F. Stanaszek
N2 - The current status of cancer chemotherapy is discussed in terms of its history, mechanisms of action, general principles of drug combination, and combined modalities. A table of commercially available cancer chemotherapeutic drugs is presented, including mechanisms of action, dosage, toxicity, and major indications.
KW - Antineoplastic agents--combined therapy--and mechanism of action, discussion;
KW - Combined therapy--antineoplastic agents--and mechanism of action, discussion;
KW - Mechanism of action--antineoplastic agents--and combined therapy, discussion;
KW - History--antineoplastic agents--therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rhaese, Hans-Jürgen
AU - Dichtelmüller, Herbert
AU - Grade, Reinhardt
T1 - Studies on the Control of Development.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/08/15/Aug75 Part 2
VL - 56
IS - 2
M3 - Article
SP - 385
EP - 392
PB - Wiley-Blackwell
SN - 00142956
AB - Bacillus subtilis cells accumulate unusual phosphorylated substances at the end of logarithmic growth in a semi-synthetic medium. Two of these substances are guanosine 3′(2′-diphosphate 5′-diphosphate (ppGpp) and guanosine 3′(2′)-diphosphate 5′-triphosphate (pppGpp) which, in contrast to amino-acid-starved Escherichia coil cells, are not degraded in sporulating cells of B. subtilis after the addition of chloramphenicol. Moreover, inhibition of protein synthesis in growing cells of B. subtilis causes accumulation of ppGpp and pppGpp, which is also in contrast to E. coll. This was shown by isolation and characterization of substances produced in these cells after the addition of chloramphenicol. Other inhibitors of protein synthesis acting at the ribosomal level also cause the accumulation of ppGpp and pppGpp. There is no difference between the action of antibiotics affecting 50-S and/or 30-S ribosomal subunits, since chloramphenicol, tetracycline, erythromycin and neomycin cause the accumulation of almost equal amounts of these nucleotides. This apparently resolves the close connection between ppGpp accumulation and the rate of stable RNA synthesis, which was believed to exist also in B. subtilis because of the stringent response observed after amino acid starvation coupled with ppGpp accumulation. Antibiotics which inhibit protein synthesis differently than by affecting the ribosomes (puromycin) or which inhibit RNA (rifampicin) or DNA (nalidixic acid) synthesis do not cause ppGpp accumulation. The accumulation of ppGpp and pppGpp in the presence of charged tRNA provided by chloramphenicol treatment suggests that the signal for the synthesis of unusual nucleotides is an inhibition of the binding of tRNA (charged or uncharged) to the acceptor site of the ribosome. This activates the rel gcue product which forms ppGpp and pppGpp from GTP and ATP. Sporulating cells of B. subtilis without chloramphenicol treatment produce besides ppGpp and pppGpp other unusual substances, which are likely to be highly phosphorylated nucleotides contained adenine as base moiety. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS subtilis
KW - CELLS
KW - NUCLEOTIDES
KW - PROTEIN synthesis
KW - PHOSPHORYLATION
KW - TRANSFER RNA
N1 - Accession Number: 12750353; Rhaese, Hans-Jürgen 1,2 Dichtelmüller, Herbert 1,2 Grade, Reinhardt 1,2; Affiliation: 1: Arbeitsgruppe Molekulare Genetik im Fachberein Biologie, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main 2: Laboratory of Molecular Biology, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: Aug75 Part 2, Vol. 56 Issue 2, p385; Subject Term: BACILLUS subtilis; Subject Term: CELLS; Subject Term: NUCLEOTIDES; Subject Term: PROTEIN synthesis; Subject Term: PHOSPHORYLATION; Subject Term: TRANSFER RNA; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SIGGINS, G. R.
AU - HENRIKSEN, S. J.
T1 - Analogs of Cyclic Adenosine Monophosphate: Correlation of Inhibition of Purkinje Neurons with Protein Kinase Activation.
JO - Science
JF - Science
Y1 - 1975/08/15/
VL - 189
IS - 4202
M3 - Article
SP - 559
EP - 561
SN - 00368075
AB - Cyclic adenosine monophosphate (cyclic AMP) and 11 derivatives were applied to rat cerebellar Purkinje cells by iontophoresis. Cyclic AMP inhibited 63 percent of the cells, while the 8-parachlorophenylthio- and 8-benzylthio- analogs of cyclic AMP inhibited the spontaneous firing of 92 and 80 percent oj cells, respectively. The ability of the 11 analogs to inhibit neuronal firing correlated (r = + .78) with their reported potency in activating cyclic AMP-dependent protein kinase. These results extend previous studies, pointing to the mediation by cyclic AMP of the noradrenergic inhibition of Purkinje neurons, and provide new physiological evidence that protein phosphorylation is a major step in the action of cyclic AMP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136455; SIGGINS, G. R. 1; HENRIKSEN, S. J. 1; Affiliations: 1: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p559; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILLER, Louis H.
AU - MASON, STEVEN J.
AU - DVORAK, JAMES A.
AU - MCGINNISS, MARY H.
AU - ROTHMAN, IVAN K.
T1 - Erythrocyte Receptors for (Plasmodium knowlesi) Malaria: Duffy Blood Group Determinants.
JO - Science
JF - Science
Y1 - 1975/08/15/
VL - 189
IS - 4202
M3 - Article
SP - 561
EP - 563
SN - 00368075
AB - Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136456; MILLER, Louis H. 1; MASON, STEVEN J. 1; DVORAK, JAMES A. 1; MCGINNISS, MARY H. 2; ROTHMAN, IVAN K. 2; Affiliations: 1: Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Blood Bank, Clinical Center, National Institutes of Health, Bethesda 20014; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p561; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HODGKINSON, ROBERT
AU - MARX, GERTIE F.
AU - KAISER, IRWIN H.
AU - KAY STANDLEY, KAY STANDLEY
AU - KLEIN, ROBERT P.
AU - SOULE II, A. BRADLEY
T1 - Local-Regional Anesthesia During Childbirth and Newborn Behavior.
JO - Science
JF - Science
Y1 - 1975/08/15/
VL - 189
IS - 4202
M3 - Article
SP - 571
EP - 572
SN - 00368075
N1 - Accession Number: 85136461; HODGKINSON, ROBERT 1; MARX, GERTIE F. 1; KAISER, IRWIN H. 2; KAY STANDLEY, KAY STANDLEY 3; KLEIN, ROBERT P. 3; SOULE II, A. BRADLEY 3; Affiliations: 1: Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York 10461; 2: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine; 3: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 8/15/1975, Vol. 189 Issue 4202, p571; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Baron, M.;
AU - Gershon, E. S.;
AU - Rudy, V.;
AU - Jonas, W. Z.;
AU - Buchsbaum, M.;
T1 - Lithium carbonate response in depression: prediction by unipolar/bipolar illness, average evoked response, catechol-O-transferase, and family history
CT - Lithium carbonate response in depression: prediction by unipolar/bipolar illness, average evoked response, catechol-O-transferase, and family history
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/09/01/
VL - 32
IS - Sep
SP - 1107
EP - 1111
AD - Dept. of Research, Jerusalem Mental Health Center, Israel and the Div. of Clinical and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland
N1 - Accession Number: 13-3423; Language: English; Chemical Name: Lithium carbonate--554-13-2; References: 46; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Bipolar depressed patients had significantly more frequent unequivocal responses than the unipolar patients in a double blind study of 23 hospitalized depressed subjects who received lithium carbonate at a therapeutic level between 0.8 to 1.0 meq/l of serum lithium concentration.
KW - Lithium carbonate--blood levels-;
KW - Blood levels--lithium carbonate--therapy, in unipolar and bipolar depressed patients;
KW - Metabolism--lithium carbonate--blood levels, therapy, in unipolar and bipolar depressed patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tormey, D. C.;
T1 - Combined chemotherapy and surgery in breast cancer: a review
CT - Combined chemotherapy and surgery in breast cancer: a review
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1975/09/01/
VL - 36
IS - Sep
SP - 881
EP - 892
AD - Medical Breast Cancer Service, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-3417; Language: English; References: 53; Publication Type: Review; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning 8 trials utilizing 9 single agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various patient subsets. Some of the possible reasons for the observed differences, and their implications for future studies, are discussed.
KW - Antineoplastic agents--and surgery--therapy, in breast cancer, review, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Achenbach, Thomas M.
AU - Weisz, John R.
T1 - A Longitudinal Study of Relations between Outer-Directedness and IQ Changes in Preschoolers.
JO - Child Development
JF - Child Development
Y1 - 1975/09//
VL - 46
IS - 3
M3 - Article
SP - 650
EP - 657
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12188439; Achenbach, Thomas M. 1 Weisz, John R. 2; Affiliation: 1: National Institute of Mental Health 2: Cornell University; Source Info: Sep1975, Vol. 46 Issue 3, p650; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1467-8624.ep12188439
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Rauscher, F. J.;
T1 - National Cancer Institute safety standards for research involving chemical carcinogens. Part 127
CT - National Cancer Institute safety standards for research involving chemical carcinogens. Part 127
JO - J. Chem. Educ.
JF - J. Chem. Educ.
Y1 - 1975/09/01/
VL - 52
IS - Sep
SP - A419
EP - A425
AD - National Cancer Program, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-1777; Language: English; Publication Type: Safety in the Chemical Laboratory; Journal Coden: JCEDA8; Section Heading: Methodology
KW - Standards--safety--carcinogens, National Cancer Institute;
KW - Safety--standards--carcinogens, National Cancer Institute;
KW - Carcinogens--safety--standards, National Cancer Institute;
KW - Toxicity--carcinogens--safety, National Cancer Institute standards;
KW - Chemicals--carcinogens--standards, safety, National Cancer Institute;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - FELIX, EDWARD L.
AU - LOYD, BETTY
AU - COHEN, MAX H.
T1 - Inhibition of the Growth and Development of a Transplantable Murine Melanoma by Vitamin A.
JO - Science
JF - Science
Y1 - 1975/09/12/
VL - 189
IS - 4206
M3 - Article
SP - 886
EP - 888
SN - 00368075
AB - Vitamin A, given either orally or intraperitoneally, has a dramatic inhibitory effect on the growth and development of a highly immunogenic murine melanoma. This effect may be due to enhancement of antitumor immunity by vitamin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136602; FELIX, EDWARD L. 1; LOYD, BETTY 1; COHEN, MAX H. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/12/1975, Vol. 189 Issue 4206, p886; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILES, F. A.
AU - FULLER, J. H.
T1 - Visual Tracking and the Primate Flocculus.
JO - Science
JF - Science
Y1 - 1975/09/19/
VL - 189
IS - 4207
M3 - Article
SP - 1000
EP - 1002
SN - 00368075
AB - Purkinje cells in the primate flocculus discharge specifically in relation to visual tracking, effectively generating a velocity profile of the target during pursuit. It is suggested that these neurons supply oculomotor centers with the velocity command signals needed to support pursuit eye movements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136640; MILES, F. A. 1; FULLER, J. H. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/19/1975, Vol. 189 Issue 4207, p1000; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOOVER, ROBERT
AU - MASON, THOMAS J.
AU - MCKAY, FRANK W.
AU - FRAUMENI JR., JOSEPH F.
T1 - Cancer by County: New Resource for Etiologic Clues.
JO - Science
JF - Science
Y1 - 1975/09/19/
VL - 189
IS - 4207
M3 - Article
SP - 1005
EP - 1007
SN - 00368075
AB - Mapping of U.S. cancer mortality by county has revealed patterns of etiologic significance. Th'e patterns for bladder cancer in males point to industrial determinants: some are known (chemical manufacturing) but others (autom'obile and machinery manufacturing)' represent new leads for epidemiologic study.' By contrast, the geographic clusters of high rates of stomach cancer in both sexes are consistent with eth'nic susceptibility. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136642; HOOVER, ROBERT 1; MASON, THOMAS J. 1; MCKAY, FRANK W. 1; FRAUMENI JR., JOSEPH F. 1; Affiliations: 1: Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/19/1975, Vol. 189 Issue 4207, p1005; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Bowery, Thomas G.
T1 - REPRESENTING MINORITIES.
JO - BioScience
JF - BioScience
Y1 - 1975/10//
VL - 25
IS - 10
M3 - Letter
SP - 608
EP - 608
SN - 00063568
AB - A letter to the editor is presented in response to the article "Underrepresentation of Minorities in the Biological Sciences," in the May 1975 issue.
KW - Letters to the editor
KW - Minorities
N1 - Accession Number: 28049482; Bowery, Thomas G. 1; Affiliations: 1 : Director Division of Research Resources, National Institutes of Health, Bethesda, MD 20014; Source Info: Oct1975, Vol. 25 Issue 10, p608; Subject Term: Letters to the editor; Subject Term: Minorities; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 476
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Adler, William H.
T1 - Aging and Immune Function.
JO - BioScience
JF - BioScience
Y1 - 1975/10//
VL - 25
IS - 10
M3 - Article
SP - 652
EP - 657
SN - 00063568
AB - The article focuses on research in the field of aging and immunity. It is reported that a major advance in immunology research techniques has been in tissue culture. It is informed that the technique has allowed investigators to move their attention from the intact organism to the tissues and cells of the immune system. It is reported that in the study of stem cell activity, some experiments show no defect in the number or differentiation potential of the cells in the aging host. According to the author, if the possible nonlymphoreticular causes of an environmental defect are ignored, it is possible to examine the various facets of the aging immune system that lead to decreased antibody production.
KW - Life sciences
KW - Aging -- Research
KW - Immunology -- Research
KW - Immune system
KW - Immunoglobulins
KW - Stem cells
KW - Gerontology
KW - Developmental biology
KW - Medical care
N1 - Accession Number: 28049494; Adler, William H. 1; Affiliations: 1 : Laboratory of Cellular and Comparative Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, and the Baltimore City Hospitals, Baltimore, MD 21224; Source Info: Oct1975, Vol. 25 Issue 10, p652; Thesaurus Term: Life sciences; Subject Term: Aging -- Research; Subject Term: Immunology -- Research; Subject Term: Immune system; Subject Term: Immunoglobulins; Subject Term: Stem cells; Subject Term: Gerontology; Subject Term: Developmental biology; Subject Term: Medical care; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 5211
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DP - EBSCOhost
DB - 8gh
ER -
TY - NEWS
AU - Fredrickson, Donald S.
T1 - Finding answers to health care problems: A job for researchers, practitioners, and the public.
JO - Geriatrics
JF - Geriatrics
Y1 - 1975/10//
VL - 30
IS - 10
M3 - Editorial
SP - 43
EP - 50
SN - 0016867X
N1 - Accession Number: 17729442; Fredrickson, Donald S. 1; Source Information: Oct1975, Vol. 30 Issue 10, p43; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1476
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Miller, W. L.;
AU - Doppman, J. L.;
AU - Kaplan, A. P.;
T1 - Renal arteriography following systemic reaction to contrast material
CT - Renal arteriography following systemic reaction to contrast material
JO - J. Allergy Clin. Immunol.
JF - J. Allergy Clin. Immunol.
Y1 - 1975/10/01/
VL - 56
IS - Oct
SP - 291
EP - 295
AD - National Institute of Allergy and Infectious Diseases, NHLI, Bldg 10, Rm. 11N 246, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-6473; Language: English; Trade Name: Conray--Benadryl; Generic Name: Iothalamate meglumine; Diphenhydramine hydrochloride; Chemical Name: Diphenhydramine hydrochloride--147-24-0 Prednisone--53-03-2 Iothalamate meglumine--13087-53-1; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone and diphenhydramine hydrochloride (4:00); AHFS Class: Antihistamines diphenhydramine hydrochloride and prednisone; References: 16; Journal Coden: JACIBY; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Ronald E. Nagata, Jr.
N2 - Pretreatment with 80 mg prednisone and 200 mg diphenhydramine HCl (Benadryl) daily for 3 days prior to arteriography and challenge with increasing quantities of IV iothalamate meglumine (Conray) allowed for successful performance of arteriography in a 15-yr-old female with severe hypertension (220/160), a patient who had 2 previous anaphylaxis-like reactions to contrast materials. Pretreatment with a steroid-antihistaminic regimen may protect patients when the alternatives to performance of radiographic contrast studies appear to provide no less risk.
KW - Diphenhydramine hydrochloride--and prednisone-;
KW - Prednisone--and diphenhydramine hydrochloride-;
KW - Iothalamate meglumine--adverse reactions-;
KW - Combined therapy--diphenhydramine hydrochloride and prednisone--adverse reactions, prevention in iothalamate arteriography patients s*r e23.4 = adverse reactions, prevention in iothalamate arteriography patients;
KW - Combined therapy--prednisone and diphenhydramine hydrochloride--adverse reactions, prevention in iothalamate arteriography patients;
KW - Steroids, cortico---prednisone and diphenhydramine hydrochloride--prevention, iothalamate adverse reactions, arteriography, patients;
KW - Antihistamines--diphenhydramine hydrochloride and prednisone--prevention, iothalamate adverse reactions, arteriography, patients;
KW - Roentgenographic agents--lothalamate meglumine--adverse reactions, prevention, using diphenhydramine and prednisone therapy, arteriography, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Malone, W. F.;
T1 - Occupational cancer control and prevention. Part 128
CT - Occupational cancer control and prevention. Part 128
JO - J. Chem. Educ.
JF - J. Chem. Educ.
Y1 - 1975/10/01/
VL - 52
IS - Oct; Nov
SP - A468
EP - A511
AD - Prevention Branch, Div. of Cancer Control and Rehabilitation, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-2116; Language: English; References: 38; Publication Type: Safety in the Chemical Laboratory; Journal Coden: JCEDA8; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Douglas L. Thompson
N2 - The objectives of a cancer prevention program are outlined. Sources of information on carcinogens are included. A list of carcinogens for which occupational safety and health standards have been issued is included as is a list of chemicals reviewed in International Agency for Research on Cancer monographs on the evaluation of the carcinogenicity of chemicals to men.
KW - Toxicity, environmental--carcinogens--control, occupational, and cancer prevention;
KW - Control--carcinogens--occupational;
KW - Carcinogens--control--occupational, and cancer prevention;
KW - Chemicals--carcinogens--control, occupational cancer, and prevention;
KW - Information--carcinogens--sources;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06267-016
AN - 2006-06267-016
AU - Levitin, Teresa
T1 - Is One Role Enough? Are Two Too Many?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1975/10//
VL - 20
IS - 10
SP - 788
EP - 789
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06267-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levitin, Teresa; National Institute of Mental Health, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Employment Status; Family; Mother Child Relations; Working Women. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Hoffman, Lois W.; Nye, F. Ivan. Lois W. Hoffman and F. Ivan Nye=San Francisco: Jossey-Bass, 1974. Pp. xiv + 272. $12.50; 1974. Page Count: 2. Issue Publication Date: Oct, 1975.
AB - Reviews the book, Working Mothers by Lois W. Hoffman and F. Ivan Nye (1974). Working Mothers is a timely, readable book that reviews and evaluates much of the literature on the effects of maternal employment. The literature in this area is largely inconsistent, incomplete, and atheoretical; a major strength of Working Mothers is that these problems are not ignored. 'The most distressing aspect of the current research situation is the lack of theory' and this book reflects that situation. The book is best when data are organized around general approaches or hypotheses, as in the chapter on the child, and least satisfactory when a model is proposed but neither adequately justified nor well integrated with the literature, as with the chapter on the family. Consequently, this book could be used at the undergraduate level and would be useful not only as a text for students in marriage and the family, women's studies, and related courses, but also as a reference for social science researchers and practitioners. The Bibliography is extensive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - working mothers
KW - maternal employment
KW - family
KW - mother child relations
KW - 1975
KW - Employment Status
KW - Family
KW - Mother Child Relations
KW - Working Women
KW - 1975
U2 - Hoffman, Lois W.; Nye, F. Ivan. (1974); Lois W. Hoffman and F. Ivan Nye; San Francisco: Jossey-Bass, 1974. Pp. xiv + 272. $12.50
DO - 10.1037/014289
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06267-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41591-015
AN - 2013-41591-015
AU - Abion, Steven L.
AU - Davenport, Yolande B.
AU - Gershon, Elliot S.
AU - Adland, Marvin L.
T1 - The married manic.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1975/10//
VL - 45
IS - 5
SP - 854
EP - 866
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Davenport, Yolande B., National Institute of Mental Health, 9000 Rockville Pike, Bldg. 10, Rm. 45239, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-41591-015. Partial author list: First Author & Affiliation: Abion, Steven L.; Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Group Psychotherapy; Major Depression; Therapeutic Processes; Interpersonal Relationships. Minor Descriptor: Clinical Psychology; Marriage; Psychodynamics. Classification: Affective Disorders (3211); Group & Family Therapy (3313). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 1975.
AB - In group psychotherapy and follow-up studies, the interpersonal relationships and psychodynamics of the married manic depressive patient and spouse were studied. Prominent among these subjects were massive denial of grief, rage, and dependency in the context of symbiotic relationships; and the absence of a father during early development. Clinical expressions of these factors are presented, and therapeutic implications are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical expressions
KW - group psychotherapy
KW - interpersonal relationships
KW - manic depression
KW - symbiotic relationships
KW - therapeutic implications
KW - marriage
KW - psychodynamics
KW - 1975
KW - Bipolar Disorder
KW - Group Psychotherapy
KW - Major Depression
KW - Therapeutic Processes
KW - Interpersonal Relationships
KW - Clinical Psychology
KW - Marriage
KW - Psychodynamics
KW - 1975
DO - 10.1111/j.1939-0025.1975.tb01213.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41591-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FLIER, JEFFREY S.
AU - KAHN, C. RONALD
AU - ROTH, JESSE
AU - BAR, ROBERT S.
T1 - Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance.
JO - Science
JF - Science
Y1 - 1975/10/03/
VL - 190
IS - 4209
M3 - Article
SP - 63
EP - 65
SN - 00368075
AB - Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002732; FLIER, JEFFREY S. 1; KAHN, C. RONALD 1; ROTH, JESSE 1; BAR, ROBERT S. 1; Affiliations: 1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/ 3/1975, Vol. 190 Issue 4209, p63; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KEBABIAN, JOHN W.
AU - BLOOM, FLOYD E.
AU - STEINER, ALTON L.
AU - GREENGARD, PAUL
T1 - Neurotransmitters Increase Cyclic Nucleotides in Postganglionic Neurons: Immunocytochemical Demonstration.
JO - Science
JF - Science
Y1 - 1975/10/10/
VL - 190
IS - 4210
M3 - Article
SP - 157
EP - 159
SN - 00368075
AB - Dopamine increases adenosine 3',5'-monophosphate (cyclic AMP) but not guanosine 3',5'-monophosphate (cyclic GMP) in slices of bovine sympathetic ganglion; this increase is localized to the postganglionic neurons. Conversely, acetylcholine increases cyclic GMP but not cyclic AMP in the ganglion; this increase also occurs within postganglionic neurons. Thus, different neurotransmitters can selectively alter cyclic nucleotide levels within the same neuronal population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136692; KEBABIAN, JOHN W. 1; BLOOM, FLOYD E. 2; STEINER, ALTON L. 3; GREENGARD, PAUL 4; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropharmacology, St. Elizabeths Hospital, Washington, D.C.; 3: Department of Medicine, University of North Carolina, Chapel Hill 27514; 4: Department of Pharmacology, Yale Medical School, New Haven, Connecticut 06510; Issue Info: 10/10/1975, Vol. 190 Issue 4210, p157; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HANSEN, JAMES W.
AU - HOFFMAN, HOWARD J.
AU - ROSS, GRIFF T.
T1 - Monthly Gonadotropin Cycles in Premenarcheal Girls.
JO - Science
JF - Science
Y1 - 1975/10/10/
VL - 190
IS - 4210
M3 - Article
SP - 161
EP - 163
SN - 00368075
AB - Patterns of nocturnal excretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were investigated in 11 girls. A utoregressive digital filtering of low- and high-frequency variations was used to make patterns more apparent. Coincident FSH and LH surges, separated by an interval of 20 to 40 days, were seen in specimens from three of six postmenarcheal girls and three to five premenarcheal girls. This suggests that cyclic hypothalamic-pituitary-ovarian interactions occur before menarche. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136694; HANSEN, JAMES W. 1; HOFFMAN, HOWARD J. 1; ROSS, GRIFF T. 1; Affiliations: 1: Reproduction Research Branch and Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 10/10/1975, Vol. 190 Issue 4210, p161; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Rosenoff, S. H.;
AU - Brooks, E.;
AU - Bostick, F.;
AU - Young, R. C.;
T1 - Alterations in DNA synthesis in cardiac tissue induced by adriamycin (doxorubicin) in vivo\M/relationship to fatal toxicity
CT - Alterations in DNA synthesis in cardiac tissue induced by adriamycin (doxorubicin) in vivo\M/relationship to fatal toxicity
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1975/10/15/
VL - 24
IS - Oct 15
SP - 1898
EP - 1901
AD - Cellular Kinetics Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-3505; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 21; Publication Type: Letters; Journal Coden: BCPCA6; Section Heading: Pharmacology; Abstract Author: Douglas L. Thompson
N2 - Doxorubicin was shown to inhibit DNA synthesis in mouse cardiac tissue. A single dose of 10 mg/kg produced an early, mild depression of DNA synthesis which returned to control levels after 12 hr, and was followed by a delayed depression of DNA synthesis in the heart which was temporally related to fatal toxicity. This depression is more marked at the more toxic dose of 20 mg/kg. In addition to the alterations seen in DNA synthesis, histologic sections of mouse hearts stained with hematoxylin-eosin after a single dose of 15 mg/kg showed myocytolytic changes, similar to those described in patients with daunorubicin induced cardiomyopathy.
KW - Doxorubicin--toxicity-;
KW - Toxicity--doxorubicin--cardiac, inhibition of DNA synthesis, in mice;
KW - Antineoplastic agents--doxorubicin--toxicity, cardiac, inhibition of DNA synthesis, in mice;
KW - Tissue levels--doxorubicin--toxicity, cardiac, inhibition of DNA synthesis, in mice;
KW - Metabolism--doxorubicin--tissue levels, cardiac, inhibition of DNA synthesis, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BARR, RONALD D.
AU - WHANG-PENG, JACQUELINE
AU - PERRY, SEYMOUR
T1 - Hemopoietic Stem Cells in Human Peripheral Blood.
JO - Science
JF - Science
Y1 - 1975/10/17/
VL - 190
IS - 4211
M3 - Article
SP - 284
EP - 285
SN - 00368075
AB - A population of lymphocytes, separable from the great majority by virtue of their larger size and their failure to exhibit the rosetting characteristic of thymus-dependent lymphocytes and bursa-equivalent cells, possess true pluripoteinality. On culture in vivo they proliferate and differentate into erythrocytic, granulocytic, and megakarvocvtic progeny. This may be the first clear demionstration of the primitive progenitor blood cell in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002750; BARR, RONALD D. 1; WHANG-PENG, JACQUELINE 1; PERRY, SEYMOUR 2; Affiliations: 1: Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: National Institutes of Health, Bethesda, Maryland; Issue Info: 10/17/1975, Vol. 190 Issue 4211, p284; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ARINTS, JOHN
AU - SIEKEVITZ, PHILIP
AU - SHANNON, THOMAS A.
AU - STETTEN JR., DEWITT
T1 - Controversial Areas of Research.
JO - Science
JF - Science
Y1 - 1975/10/24/
VL - 190
IS - 4212
M3 - Article
SP - 328
EP - 330
SN - 00368075
N1 - Accession Number: 88002758; ARINTS, JOHN 1; SIEKEVITZ, PHILIP 2; SHANNON, THOMAS A. 3; STETTEN JR., DEWITT 4; Affiliations: 1: Department of Chemnistry, City College, City University of New York, New York 10031; 2: Department of Cell Biology. Rockefeller University, New York 10021; 3: Departmiient of Humanities. Worcester Polytechnic Institute, Worcester, Massachusetts Al1609; 4: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/24/1975, Vol. 190 Issue 4212, preceding p328; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEISSBACH, ARTHUR
AU - BALTIMORE, DAVID
AU - BOLLUM, FRED
AU - CALLO, ROBERT
AU - KORN, DAVID
T1 - Nomenclature of Eukaryotic DNA Polymerases.
JO - Science
JF - Science
Y1 - 1975/10/24/
VL - 190
IS - 4212
M3 - Article
SP - 401
EP - 402
SN - 00368075
N1 - Accession Number: 88002775; WEISSBACH, ARTHUR 1; BALTIMORE, DAVID 2; BOLLUM, FRED 3; CALLO, ROBERT 4; KORN, DAVID 5; Affiliations: 1: Roche Institute of Molecular Biology, Nutlev, New Jersey 07110; 2: Massachusetts Institute of Technology Cambridge 02139; 3: University of Kentucky Medical Center, Lexington 40506; 4: National Cancer Institute, Bethesda, Maryland 20014; 5: Stanford University, Palo Alto, California 94305; Issue Info: 10/24/1975, Vol. 190 Issue 4212, p401; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - POST, ROBERT M.
AU - GOODWIN, FREDERICK K.
T1 - Time-Dependent Effects of Phenothiazines on Dopamine Turnover in Psychiatric Patients.
JO - Science
JF - Science
Y1 - 1975/10/31/
VL - 190
IS - 4213
M3 - Article
SP - 488
EP - 489
SN - 00368075
AB - Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinalfluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turnover that may be relevant to the time course of antipsychotic efficacy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002797; POST, ROBERT M. 1; GOODWIN, FREDERICK K. 2; Affiliations: 1: Section on Psychobiology, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 10/31/1975, Vol. 190 Issue 4213, p488; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Chatterju, D.;
AU - Hiranaka, P. K.;
AU - Gallelli, J. F.;
T1 - Stability of sodium oxacillin in intravenous solutions
CT - Stability of sodium oxacillin in intravenous solutions
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1975/11/01/
VL - 32
IS - Nov
SP - 1130
EP - 1132
SN - 00029289
AD - Pharmacy Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-1073; Language: English; Trade Name: Glucose; Generic Name: Dextrose; Chemical Name: Oxacillin--66-79-5 Dextrose--5996-10-1; References: 7; Journal Coden: AJHPA9; Section Heading: Drug Stability
N2 - The influence of concentration, vehicle, dextrose (glucose) and temperature on the stability of sodium oxacillin (I) solutions was determined using a chemical kinetic approach. I degraded faster in dextrose solution than in sodium chloride injection. This finding was attributed to the catalytic effect of dextrose on I hydrolysis. Solutions of 1-50 mg/ml I in each vehicle were found to be stable for 24 hr at 23\DG/ C. The degradation of I in various dextrose solutions was independent of I concentration, and followed first order kinetics.
KW - Oxacillin--injections-;
KW - Dextrose--oxacillin-;
KW - Injections--intravenous--oxacillin, stability, effects of concentration, vehicle, dextrose and temperature;
KW - Stability--oxacillin--injections, IV, effects of concentration, vehicle, dextrose and temperature;
KW - Concentration--oxacillin--injections, IV, effects on stability;
KW - Vehicles--oxacillin--injections, IV, effects on stability;
KW - Temperature--oxacillin--injections, IV, effects on stability;
KW - Kinetics--oxacillin--injections, IV, stability, in dextrose solutions;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Prescott, James W.
T1 - BODY PLEASURE AND THE ORIGINS OF VIOLENCE.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1975/11//
VL - 31
IS - 9
M3 - Article
SP - 10
EP - 20
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21596282; Prescott, James W. 1; Affiliation: 1: Health Scientist Administrator, National institute of Child Health and Human Development, Bethesda, Maryland; Source Info: Nov1975, Vol. 31 Issue 9, p10; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Silverman, N. A.
AU - Potvin, C.
AU - Alexander, Jr., J. C.
AU - Chretien, P. B.
T1 - IN VITRO LYMPHOCYTE REACTIVITY AND T-CELL LEVELS IN CHRONIC CIGARETTE SMOKERS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/11//
VL - 22
IS - 2
M3 - Article
SP - 285
EP - 292
PB - Wiley-Blackwell
SN - 00099104
AB - Peripheral blood total leucocyte, lymphocyte and thymus-dependent lymphocyte (T cell) levels and in vitro lymphocyte reactivity (LR) to phytohaemagglutinin (PHA) were determined in 153 chronic cigarette smokers and 115 non-smokers ranging in age front 20 to 78 years. Total leucocyte, lymphocyte and T-cell levels were significantly elevated in smokers. There was no correlation with age. LR to P1-IA was significantly higher in smokers less than 40 years of age or in those with a 20 pack- year or less history of cigarette consumption. Older smokers or those with a history of heavier cigarette consumption did not differ from normals. The results contrast with previous demonstrations of suppression of immune reactivity after exposure to tobacco products. The possible effects of the apparent stimulation of the lymphoid system by chronic cigarette consumption is considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIPHERAL circulation
KW - LEUCOCYTES
KW - LYMPHOCYTES
KW - T cells
KW - CIGARETTE smokers
KW - IMMUNITY
KW - TOBACCO industry
KW - LYMPHOID tissue
N1 - Accession Number: 15931805; Silverman, N. A. 1 Potvin, C. 1 Alexander, Jr., J. C. 1 Chretien, P. B. 1; Affiliation: 1: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Nov1975, Vol. 22 Issue 2, p285; Subject Term: PERIPHERAL circulation; Subject Term: LEUCOCYTES; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: CIGARETTE smokers; Subject Term: IMMUNITY; Subject Term: TOBACCO industry; Subject Term: LYMPHOID tissue; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Griffth, J. D.;
AU - Nutt, J. G.;
AU - Jasinski, D. R.;
T1 - Comparison of fenfluramine and amphetamine in man
CT - Comparison of fenfluramine and amphetamine in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1975/11/01/
VL - 18
IS - Nov
SP - 563
EP - 570
SN - 00099236
AD - National Institute on Drug Abuse, Div. of Research, Addiction Research Center, P.O. Box 12390, Lexington, Kentucky 40511
N1 - Accession Number: 13-6138; Language: English; Chemical Name: Fenfluramine--458-24-2 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Anorexics dextroamphetamine, comparison, fenfluramine (28:20); AHFS Class: Anorexics fenfluramine, comparison, dextroamphetamine; References: 23; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Fenfluramine HCl (I), 60, 120 and 240 mg, dextroamphetamine (II), 20 and 40 mg, and placebo were compared in 8 postaddict volunteers, each dose given orally in random sequence at weekly intervals using a double blind crossover design. I had little effect on blood pressure and temperature, but caused a marked dilation of pupils, whereas II was a potent vasopressor and a weak mydriatic. While I produced euphoria in some subjects, its overall effects were unpleasant, sedative, and qualitatively different from II. Three subjects given 240 mg of I experienced brief but vivid hallucinogenic episodes characterized by olfactory, visual, and somatic hallucinations, abrupt polar changes in mood, time distortion, fleeting paranoia, and sexual ideation. Observations indicate that I is a hallucinogenic agent with a pharmacologic profile in man that is not amphetamine-like.
KW - Fenfluramine--comparison, dextroamphetamine-;
KW - Dextroamphetamine--comparison, fenfluramine-;
KW - Dosage--fenfluramine, comparison, dextroamphetamine--effects, physiological and psychological, humans;
KW - Dosage--dextroamphetamine, comparison, fenfluramine--effects, physiological and psychological, humans;
KW - Anorexics--dextroamphetamine, comparison, fenfluramine--dosage, physiological and psychological effects, humans;
KW - Anorexics--fenfluramine, comparison, dextroamphetamine--dosage, physiological and psychological effects, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Weissbach, Arthur
AU - Baltimore, David
AU - Bollum, Fred
AU - Gallo, Robert
AU - Korn, David
T1 - Nomenclature of Eukaryotic DNA Polymerases.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/11//Nov75 Part 1
VL - 59
IS - 1
M3 - Article
SP - 1
EP - 2
PB - Wiley-Blackwell
SN - 00142956
AB - Proposes a nomenclature of eukaryotic DNA polymerases. DNA polymerase-α; DNA polymerase-β; DNA polymerase-γ; Mitochondrial DNA polymerase.
KW - DNA polymerases
KW - MITOCHONDRIAL DNA
KW - EUKARYOTIC cells
KW - NAMES
KW - GREEK letters
KW - VIRUS diseases
N1 - Accession Number: 15806384; Weissbach, Arthur 1 Baltimore, David 2 Bollum, Fred 3 Gallo, Robert 4 Korn, David 5; Affiliation: 1: Department of Cell Biology, Roche Institute of Molecular Biology, 340 Kingsland Road, Nutley, New Jersey, U.S.A. 07110 2: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, U.S.A. 02139 3: Department of Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, U.S.A. 40506 4: National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, U.S.A. 20014 5: Department of Pathology, Stanford University School of Medicine, Stanford, California, U.S.A. 94305; Source Info: Nov75 Part 1, Vol. 59 Issue 1, p1; Subject Term: DNA polymerases; Subject Term: MITOCHONDRIAL DNA; Subject Term: EUKARYOTIC cells; Subject Term: NAMES; Subject Term: GREEK letters; Subject Term: VIRUS diseases; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weissbach, Arthur
AU - Baltimore, David
AU - Bollum, Fred
AU - Gallo, Robert
AU - Korn, David
T1 - Nomenclature of Eukaryotic DNA Polymerases.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/11//Nov75 Part 1
VL - 59
IS - 1
M3 - Article
SP - 1
EP - 2
SN - 00142956
AB - Proposes a nomenclature of eukaryotic DNA polymerases. DNA polymerase-α; DNA polymerase-β; DNA polymerase-γ; Mitochondrial DNA polymerase.
KW - DNA polymerases
KW - MITOCHONDRIAL DNA
KW - EUKARYOTIC cells
KW - NAMES
KW - GREEK letters
KW - VIRUS diseases
N1 - Accession Number: 15806384; Weissbach, Arthur 1; Baltimore, David 2; Bollum, Fred 3; Gallo, Robert 4; Korn, David 5; Source Information: Nov75 Part 1, Vol. 59 Issue 1, p1; Subject: DNA polymerases; Subject: MITOCHONDRIAL DNA; Subject: EUKARYOTIC cells; Subject: NAMES; Subject: GREEK letters; Subject: VIRUS diseases; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Neugarten, Bernice L.
T1 - Expanded options for meeting the differing needs of the young-old and the old-old.
JO - Geriatrics
JF - Geriatrics
Y1 - 1975/11//
VL - 30
IS - 11
M3 - Interview
SP - 41
EP - 52
SN - 0016867X
N1 - Accession Number: 18239341; Neugarten, Bernice L. 1,2; Source Information: Nov1975, Vol. 30 Issue 11, p41; Number of Pages: 4p; Document Type: Interview; Full Text Word Count: 1906
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Bigelow, L. B.;
AU - Gillin, J. C.;
AU - Semal, C.;
AU - Wyatt, R. J.;
T1 - Thyrotropin releasing hormone in chronic schizophrenia
CT - Thyrotropin releasing hormone in chronic schizophrenia
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1975/11/01/
VL - 2
IS - Nov 1
SP - 869
EP - 870
SN - 00237507
AD - Lab. of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Wm. A. White Building, Washington, D.C. 20032
N1 - Accession Number: 13-2237; Language: English; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents thyrotropin releasing hormone; References: 10; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - No beneficial effects were observed when thyrotropin releasing hormone (600 mcg for 5 days) was administered to 3 treatment-resistant schizophrenic males.
KW - Thyrotropin releasing hormone--schizophrenia-;
KW - Psychotherapeutic agents--thyrotropin releasing hormone--schizophrenia, lack effect, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Buchsbaum, Monte
AU - Giwn, J. Christian
AU - Pfefferbaum, Adolf
T1 - Effect of Sleep Stage and Stimulus Intensity on Auditory Average Evoked Responses.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1975/11//
VL - 12
IS - 6
M3 - Article
SP - 707
EP - 712
SN - 00485772
AB - Auditory average evoked responses (AERs) to clicks ranging from SO to 80 dB were studied in 9 normal adults while awake and during sleep. AER amplitude tended to increase little from 50 to 80 dB in waking subjects but increased markedly in sleeping subjects during stages 3 and 4. Rapid eye movement (REM) and stage 1 sleep had small amplitude AERs in comparison with other sleep stages. Individuals who showed decreases in amplitude at high intensities while awake slept significantly longer during the experimental nights. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUDITORY evoked response
KW - SLEEP -- Stages
KW - AUDITORY perception
KW - SLEEP -- Physiological aspects
KW - STIMULUS intensity
KW - RAPID eye movement sleep
KW - Auditory evoked responses
KW - Reducing
KW - REM sleep.
KW - Sleep stage
KW - Stimulus intensity
N1 - Accession Number: 11728788; Buchsbaum, Monte 1 Giwn, J. Christian 1 Pfefferbaum, Adolf 1; Affiliation: 1: Adult Psychiatry Branch and Laboratory of Clinical Psychopharmacology. National Institute of Mental Health, Bethesda.; Source Info: Nov1975, Vol. 12 Issue 6, p707; Subject Term: AUDITORY evoked response; Subject Term: SLEEP -- Stages; Subject Term: AUDITORY perception; Subject Term: SLEEP -- Physiological aspects; Subject Term: STIMULUS intensity; Subject Term: RAPID eye movement sleep; Author-Supplied Keyword: Auditory evoked responses; Author-Supplied Keyword: Reducing; Author-Supplied Keyword: REM sleep.; Author-Supplied Keyword: Sleep stage; Author-Supplied Keyword: Stimulus intensity; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1469-8986.ep11728788
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Groves, Philip M.
AU - Wilson, Charles J.
AU - Young, Stephen J.
AU - Rebec, George V.
T1 - Self-Inhibition by Dopaminergic Neurons.
JO - Science
JF - Science
Y1 - 1975/11/07/
VL - 190
IS - 4214
M3 - Article
SP - 522
EP - 529
SN - 00368075
N1 - Accession Number: 88002802; Groves, Philip M. 1; Wilson, Charles J. 2; Young, Stephen J. 3; Rebec, George V. 4; Affiliations: 1: Professor of psychology, biopsychology area of the Department of Psychology, University of Colorado, Boulder 80302; 2: A faculty research associate, University of Colorado; 3: Graduate student in biopsychology, University of Colorado; 4: National Institute of Mental Health postdoctoral fellow, Department of Psychiatry, University of California, San Diego Medical School, La Jolla 92037; Issue Info: 11/ 7/1975, Vol. 190 Issue 4214, p522; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BENVENISTE, RAOUL E.
AU - SHERR, CHARLES J.
AU - TODARO, GEORGE J.
T1 - Evolution of Type C Viral Genes: Origin of Feline Leukemia Virus.
JO - Science
JF - Science
Y1 - 1975/11/28/
VL - 190
IS - 4217
M3 - Article
SP - 886
EP - 888
SN - 00368075
AB - Reiterated gene sequences related to the RNA of feline leukemia virus (FeL V) are detected in all tissues of domestic cats and their close Felis relatives but not in more distantlv related Felis species. Partiallv homologous viral gene sequences are found in rodent, and particularlv rat, DNA. Together with the immunologic relationships observed between FeL V and endogenous rodent type C viruses, the results lead to the conclusion that FeL V-related genes were transmitted from a rodent to cat ancestor and have been perpetuated in the germ line of cats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002870; BENVENISTE, RAOUL E. 1; SHERR, CHARLES J. 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p886; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHEARER, GENE M.
AU - CUDKOWICZ, GUSTAVO
T1 - Induction of F1 Hybrid Antiparent Cytotoxic Effector Cells: An in vitro Model for Hemopoietic Histoincompatibility.
JO - Science
JF - Science
Y1 - 1975/11/28/
VL - 190
IS - 4217
M3 - Article
SP - 890
EP - 893
SN - 00368075
AB - An in vitro system has been developed in which F1 spleen cells can generate cytotoxic activity directed specifically against parental cells. The antigenic differences detected are controlled by the H-2D-Hh-1 region of the murine major histocompatibility complex. The parent-F1 combinations demonstrating F1 antiparent activity in vitro are the same as those demonstrating F1 rejection of parental hemopoietic grafts in vivo. Hence, the F1 antiparent cytotoxicity test serves as an in vitro model for the recognition and effector phases of hybrid resistance to parental hemopoietic grafts and may be of value in clinical transplantation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002872; SHEARER, GENE M. 1; CUDKOWICZ, GUSTAVO 2; Affiliations: 1: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Department of Pathology, School of Medicine, State University of New York, Buffalo 14214; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p890; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEDER, AYA
AU - ORKIN, STUART
AU - LEDER, PHILIP
T1 - Differentiation of Erythroleukemic Cells in the Presence of Inhibitors of DNA Synthesis.
JO - Science
JF - Science
Y1 - 1975/11/28/
VL - 190
IS - 4217
M3 - Article
SP - 893
EP - 894
SN - 00368075
AB - Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002873; LEDER, AYA 1,2; ORKIN, STUART 1,2; LEDER, PHILIP 1,2; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel; Issue Info: 11/28/1975, Vol. 190 Issue 4217, p893; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Jaffe, R. M.;
AU - Kasten, B.;
AU - Young, D. S.;
AU - MacLowry, J. D.;
T1 - False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C)
CT - False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C)
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1975/12/01/
VL - 83
IS - Dec
SP - 824
EP - 826
SN - 00034819
AD - Building 10, Room 4-N-309, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-2870; Language: English; Trade Name: Vitamin C; Generic Name: Ascorbic acid; Chemical Name: Ascorbic acid--50-81-7; References: 13; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Karl H. Riotte
N2 - A case study and subsequent in vitro investigation involving the effect of oral ascorbic acid (I) on occult blood tests of stool is presented. A female patient with unexplained anemia who was taking 2 g/day consistently produced false negative stools for occult blood. When I was stopped, her stools became strongly reactive, and later returned to false-negative upon rechallenge. In vitro studies confirmed these findings. It was recommended that patients be taken off all I for 48 to 72 hr before tests of occult blood are done.
KW - Ascorbic acid--effects-;
KW - Drug interactions--ascorbic acid and tests, laboratory--effects, false negatives, occult blood tests, in anemic patient;
KW - Drug interactions--tests, laboratory and ascorbic acid--effects, false negatives, occult blood tests, in anemic patient;
KW - Tests, laboratory--interactions--ascorbic acid, false negative occult blood tests, in anemic patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mohr, S. J.;
AU - Chirigos, M. A.;
AU - Fuhrman, F. S.;
AU - Pryor, J. W.;
T1 - Pyran copolymer as an effective adjuvant to chemotherapy against a murine leukemia and solid tumor
CT - Pyran copolymer as an effective adjuvant to chemotherapy against a murine leukemia and solid tumor
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1975/12/01/
VL - 35
IS - Dec
SP - 3750
EP - 3754
SN - 00085472
AD - Viral Biology Branch, National Cancer Institute, NIH Bethesda, Maryland 20014
N1 - Accession Number: 13-2640; Language: English; Trade Name: Divinyl ether-maleic anhydride copolymer; Generic Name: NSC-46015; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents NSC-46015; References: 20; Journal Coden: CNREA8; Section Heading: Preliminary Drug Testing
N2 - Pyran (divinyl ether-maleic anhydride) copolymer (NSC-46015; I) is a polyanion with interferon-inducing and macrophage-stimulating properties, and therefore it has been studied as a possible antitumor agent. Extensive studies using pyran as an adjuvant to chemotherapy against the LSTRA murine leukemia and the Lewis lung carcinoma were performed. I was effective over a dose range of 0.1 to 100 mg/kg/day. Single and multiple dose schedules were both capable of producing significant numbers of cures or increasing life span, but pyran was ineffective if used without remission inducing chemotherapy. Various molecular weights of pyran copolymer were compared against I for adjuvant activity as well. In general, I tended to be the most efficacious, but all the pyran copolymers that were tested possessed significant activity.
KW - NSC-46015--leukemias-;
KW - Antineoplastic agents--NSC-46015--leukemias, therapy, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Achenbach, Thomas M.
AU - Weisz, John R.
T1 - A Longitudinal Study of Developmental Synchrony between Conceptual Indentity, Seriation, and Transitivity of Color, Number, and Length.
JO - Child Development
JF - Child Development
Y1 - 1975/12//
VL - 46
IS - 4
M3 - Article
SP - 840
EP - 848
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12242817; Achenbach, Thomas M. 1 Weisz, John R. 2; Affiliation: 1: National Institute of Mental Health. 2: Cornell University.; Source Info: Dec1975, Vol. 46 Issue 4, p840; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1467-8624.ep12242817
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Gatlin, L. A.;
AU - Grimes, G. J.;
AU - Hiranaka, P. K.;
AU - Gallelli, J. F.;
T1 - Investigational drug information
CT - Investigational drug information
JO - Drug Intell. Clin. Pharm.
JF - Drug Intell. Clin. Pharm.
Y1 - 1975/12/01/
VL - 9
IS - Dec
SP - 655
EP - 656
AD - Pharmacy Dept., Clinical Center, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 13-5130; Language: English; Trade Name: Pyrexal--SA-1064--Threodops; Generic Name: Lipexal; Lipexal; Threo-dihydroxyphenylserine; Journal Coden: DICPBB; Section Heading: Investigational Drugs; Pharmacology; Abstract Author: D. R. Tousignaut
N2 - The stability, administration and dose, use, mechanism of action, toxicology, and route of administration of D-\a/-tocopheryl polyethylene glycol 1000 succinate (D-1-T,TPGS); threo-dihydroxyphenylserine (threo-dops), and lipexal (Pyrexal, preparations SA 1064) are given in monograph form.
KW - D-\a/-Tocopheryl polyethylene glycol 1000 succinate--drugs, investigational-;
KW - Threo-dihydroxyphenylserine--drugs, investigational-;
KW - Lipexal--drugs, investigational-;
KW - Drugs, investigational--D-\a/-tocopheryl polyethylene glycol 1000 succinate--monographs;
KW - Drugs, investigational--threo-dihydroxyphenylserine--monographs;
KW - Drugs, investigational--lipexal--monographs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kamisaka, Kazuaki
AU - Habig, William H.
AU - Ketley, Jeanne N.
AU - Arias, Irwin M.
AU - Jakoby, William B.
T1 - Multiple Forms of Human Glutathione S-Transferase and Their Affinity for Bilirubin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/12//Dec75 Part 1
VL - 60
IS - 1
M3 - Article
SP - 153
EP - 161
PB - Wiley-Blackwell
SN - 00142956
AB - The initial enzymic step in mercapturic acid formation is catalyzed by glutathione S-transferase. Several species of this enzyme, designated as transferases α, β, γ, δ and ε on the basis of increasing isoelectric points, were isolated from human liver. Evidence is presented that each of the purified species is homogeneous with respect to sodium dodeceylsulfate-gel elextrophoresis. Transferases α, β and ε each appear as a single band on gel electrofocusing; transferases &gamm; and δ are present as two and three bands, respectively, with each band catalytically active. Amino acid analysis indicated the five transferases to be either very closely related or identical in this respect. All enzyme species have a molecular weight of 48 500 and consists of two apparently identical subunits. The spectrum of substrates is the same for each although the enzymes differ slightly in specific activity. As is the case for the rat liver enzymes, each of the human transferases binds bilirubin although this compound is not a substrate. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE transferase
KW - BILIRUBIN
KW - LIVER
KW - AMINO acids
KW - MOLECULAR weights
KW - GEL electrophoresis
N1 - Accession Number: 13482982; Kamisaka, Kazuaki 1 Habig, William H. 1 Ketley, Jeanne N. 1 Arias, Irwin M. 1 Jakoby, William B. 1; Affiliation: 1: Section on Enzymes and Cellular Biochemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, and The Liver Research Center, Division of Gastroenterology-Liver-Disease, Department of Medicine, Albert Einstein College of Medicine, The Bronx, New York; Source Info: Dec75 Part 1, Vol. 60 Issue 1, p153; Subject Term: GLUTATHIONE transferase; Subject Term: BILIRUBIN; Subject Term: LIVER; Subject Term: AMINO acids; Subject Term: MOLECULAR weights; Subject Term: GEL electrophoresis; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Poplack, D. G.;
AU - Jacobs, S. A.;
T1 - Candida arthritis treated with amphotericin B
CT - Candida arthritis treated with amphotericin B
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1975/12/01/
VL - 87
IS - Dec
SP - 989
EP - 990
SN - 00223476
AD - Pediatric Oncology Branch, National Cancer Institute, NIH Bldg. 10 Rm 3B02 Bethesda, Maryland 20014
N1 - Accession Number: 13-3383; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 11; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Bette Bennett
N2 - A case report of an 11-yr-old girl with acute lymphoblastic leukemia who was treated with IV and intra-articular amphotericin B (I) for arthritis of the knee caused by Candida tropicalis is presented. Systemic therapy with I was given on 2 separate occasions, cumulative doses over 7 week periods of 480 mg and 525 mg, respectively and at a 3.5 month interval. Intra-articular injections of I at doses of one, 5 and 3 mg, respectively were then administered at 14 day intervals while systemic therapy with I was continued for 7 additional weeks to a total dose of 1.535 g. Systemic therapy with I apparently suppressed but did not eliminate the infection. Resolution of the arthritis occurred only after 3 intra-articular injections. Intra-articular administration of I may be a useful adjunct to systemic therapy in the treatment of candida arthritis.
KW - Amphotericin B--arthritis-;
KW - Arthritis--amphotericin B--Candida tropicalis, IV, comparison, intra-articular, case report;
KW - Drug administration--routes--amphotericin B, Candida tropicalis arthritis, IV, comparison, intra-articular, case report;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Tarone, Robert E.
AU - Gruenhage, Gary
T1 - A Note on the Uniqueness of Roots of the Likelihood Equations for Vector-Valued Parameters.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1975/12//
VL - 70
IS - 352
M3 - Article
SP - 903
SN - 01621459
AB - Two examples are given from the literature in which results concerning functions of a single variable are applied incorrectly to multivariate functions, One of the examples concerns the proof of a basic theorem in the theory of maximum likelihood estimation of vector-valued parameters. An alternate statement and proof of the theorem are given. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of variance
KW - ESTIMATION theory
KW - MULTIVARIATE analysis
KW - PROBABILITY theory
KW - MATHEMATICAL statistics
KW - VECTOR valued functions
KW - VECTOR-valued measures
KW - EXPERIMENTAL design
N1 - Accession Number: 4606786; Tarone, Robert E. 1; Gruenhage, Gary 2; Affiliations: 1: Research mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; 2: Instructor, Mathematics Department, Auburn Univesity, Auburn, Ala. 36830.; Issue Info: Dec75, Vol. 70 Issue 352, p903; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL statistics; Subject Term: VECTOR valued functions; Subject Term: VECTOR-valued measures; Subject Term: EXPERIMENTAL design; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Crump, Kenny
T1 - A First Course in Probability and Statistics (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1975/12//
VL - 70
IS - 352
M3 - Book Review
SP - 964
SN - 01621459
AB - Reviews the book "A First Course in Probability and Statistics," by Henrik J. Malik and Kenneth Mullen.
KW - STATISTICS
KW - PROBABILITY theory
KW - NONFICTION
KW - MALIK, Henrik J.
KW - MULLEN, Kenneth
KW - FIRST Course in Probability & Statistics, A (Book)
N1 - Accession Number: 4607066; Crump, Kenny 1; Affiliations: 1: National Institute of Environmental Health Sciences.; Issue Info: Dec75, Vol. 70 Issue 352, p964; Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: NONFICTION; Reviews & Products: FIRST Course in Probability & Statistics, A (Book); People: MALIK, Henrik J.; People: MULLEN, Kenneth; Number of Pages: 1/4p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Carter, S. K.;
T1 - Adriamycin\M/a review
CT - Adriamycin\M/a review
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1975/12/01/
VL - 55
IS - Dec
SP - 1265
EP - 1274
SN - 00278874
AD - Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-3491; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; References: 104; Publication Type: Review; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - An historical review of cancer chemotherapy and the place of Adriamycin (doxorubicin) in current therapeutic approaches is presented.
KW - Doxorubicin--cancer-;
KW - Antineoplastic agents--history--cancer, therapy, review;
KW - History--antineoplastic agents--cancer, therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Krasnegor, N. A.;
T1 - Introduction: behavioral factors in human drug abuse
CT - Introduction: behavioral factors in human drug abuse
JO - Pharmacol. Rev.
JF - Pharmacol. Rev.
Y1 - 1975/12/01/
VL - 27
IS - Dec
SP - 499
EP - 502
AD - National Institute on Drug Abuse, Rockville, Maryland
N1 - Accession Number: 14-0907; Language: English; References: 14; Journal Coden: PAREAQ; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: Ronald E. Nagata, Jr.
N2 - An introductory presentation to a series of papers on behavioral factors in human drug abuse is presented, with emphasis on new approaches and future trends in this area of research.
KW - Drug abuse--research--history, and future trends;
KW - History--drug abuse--research, and future trends;
KW - Sociology--drug abuse--research, history and future trends;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tower, D. B.;
T1 - What you should know about the epilepsies
CT - What you should know about the epilepsies
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1975/12/01/
VL - 41
IS - Dec
SP - 44
EP - 51
SN - 00030627
AD - National Institute of Neurological & Communicative Disorders & Stroke, National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 13-3237; Language: English; Journal Coden: PYTMAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2 - A discussion of the incidence, etiology, current research, prognosis, and medication and surgical treatment of the various forms of epilepsy is presented.
KW - Anticonvulsants--epilepsy--therapy, etiology and prognosis, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06269-079
AN - 2006-06269-079
AU - Wender, Paul H.
AU - Rosenthal, David
AU - Kety, Seymour S.
T1 - Distorted picture.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1975/12//
VL - 20
IS - 12
SP - 986
EP - 987
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06269-079. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wender, Paul H.; University of Utah, Salt Lake City, UT, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Schizophrenia; Treatment. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 2. Issue Publication Date: Dec, 1975.
AB - Comments on Bertram Karon's review (see record [rid]2006-06272-008[/rid]) of Theodore Lidz's book The Origin and Treatment of Schizophrenic Disorders (1973). The present authors maintain that Karon's review presents an extremely distorted picture of current understanding of the causes of schizophrenic disorders, and is, to readers unaware of recent progress in the field, grossly misleading. The following points in the review are clarified: Karon reviews Lidz's assertions that schizophrenia is produced by exposure to deviant families in childhood and adolescence. This is a familiar position that has been advanced by a number of authors antedating as well as following Lidz. Karon restates Lidz's position and quotes him as saying 'how unconvincing the widely heralded supposed evidence for genetic factors really are.' In support of this position, he mentions the fact that in one adoption study of schizophrenics, adopted parents were found to have Rorschachs indistinguishable from those of the biological parents of schizophrenics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenic disorders
KW - schizophrenia
KW - causes
KW - 1975
KW - Schizophrenia
KW - Treatment
KW - 1975
DO - 10.1037/014528
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - BUZNEY, SHELDON M.
AU - FRANK, ROBERT N.
AU - ROBISON, W. GERALD
T1 - Retinal Capillaries: Proliferation of Mural Cells in vitro.
JO - Science
JF - Science
Y1 - 1975/12/05/
VL - 190
IS - 4218
M3 - Article
SP - 985
EP - 986
SN - 00368075
AB - Capillaries from bovine, monkey, and human retinas maintained in tissue culture produced a monolayer of cells. A utoradiographic and electron microscopic evidence indicated that the mural cells (intramuralpericytes) were the c ells that proliferated. Since intramural pericytes are damaged selectively in diabetes mellitus, their availability in culture will be usejul in seeking means to control diabetic retinopathy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002888; BUZNEY, SHELDON M. 1; FRANK, ROBERT N. 1; ROBISON, W. GERALD 2; Affiliations: 1: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute; Issue Info: 12/ 5/1975, Vol. 190 Issue 4218, p985; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McLACHLAN, J. A.
AU - NEWBOLD, R. R.
AU - BULLOCK, B.
T1 - Reproductive Tract Lesions in Male Mice Exposed Prenatally to Diethylstilbestrol.
JO - Science
JF - Science
Y1 - 1975/12/05/
VL - 190
IS - 4218
M3 - Article
SP - 991
EP - 992
SN - 00368075
AB - Sixyty percent of the male off spring from pregnant mice treated with diethylistilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal orfibrotic testes, or both. Additionally, nodular masses in the ampullarv region of the reproductive tract were observed in 6 of 24 animals: one of these appeared to be preneoplastic. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002891; McLACHLAN, J. A. 1; NEWBOLD, R. R. 1; BULLOCK, B. 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Bowman-Gray School of Medicine, Winston-Salem, North Carolina 27103; Issue Info: 12/ 5/1975, Vol. 190 Issue 4218, p991; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GREEN, JON A.
AU - BARON, SAMUEL
T1 - 5-lododeoxyuridine Potentiation of the Replication In Vitro of Several Unrelated RNA and DNA Viruses.
JO - Science
JF - Science
Y1 - 1975/12/12/
VL - 190
IS - 4219
M3 - Article
SP - 1099
EP - 1101
SN - 00368075
AB - Enhancement of the replication of unrelated viruses (three RNA viruses and one DNA virus), representative of four major virus groups, occurs in human, rodent, or avian cells treated in vitro with 5-iododeoxyuridine (IdU). The results suggest that the potentiation of viral replication by IdU is a widespread phenomenon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002909; GREEN, JON A. 1; BARON, SAMUEL 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/12/1975, Vol. 190 Issue 4219, p1099; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zunino, Franco
AU - Gambetta, Romolo
AU - Colombo, Ambrogio
AU - Luoni, Giuseppe
AU - Zaccara, Adriano
T1 - DNA Polymerases of Rat Liver.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1975/12/15/Dec75 Part 2
VL - 60
IS - 2
M3 - Article
SP - 495
EP - 504
PB - Wiley-Blackwell
SN - 00142956
AB - Three distinct DNA-dependent DNA polymerase activities have been partially purified from normal rat liver. Soluble activities are separable into two distinct fractions (P1 and P2) by phosphocellulose chromatography. A low-molecular-weight DNA polymerase was isolated from purified nuclei. The enzymes were characterized according to chromatographic and sedimentation behavior, enzymological properties, and response to various inhibitors. The results indicate that fraction P1 corresponds to the high-molecular-weight enzyme and suggest that polymerase P2 may be derived from partial dissociation of the high-molecular-weight enzyme. The molecular weight of polymerase Pi was estimated to be about 250 000 by Sephadex column chromatography. Both fraction P2 and nuclear DNA polymerase appeared to be low-molecular-weight enzymes. However, the molecular size of these activities was apparently different. The estimated molecular weights of nuclear and P2 enzyme are about 40 000 and 25 000, respectively. As with the nuclear enzyme, polymerase P2 (but not P1) appeared to be free of detectable exonuclease activity. All of these polymerases showed a marked preference for initiated polydeoxyribonucleotide templates. The rat liver polymerases differed in their ability to use poly[d(A-T)] primer-template, as is shown by the ratios of their activity with this synthetic polymer to that with activated DNA: 0.5, 2.75, and 1.34 for P1, P2, and nuclear polymerase, respectively. Denatured DNA was a poor template for both enzymes P1 and P2, but it was inert as template for the nuclear enzyme. Although each of these polymerases required all four deoxynucleoside triphosphates for maximal activity, they catalyzed a high rate of synthesis in the absence of one or more deoxynucleoside triphosphates. Such a 'limited' synthesis was much more extensive for polymerase P2 and nuclear enzyme than for P1. Polymerase P1 was the most sensitive of the three to sulphydryl reagents, ethidium bromide, heparin, and single-stranded DNA. The responses of P2 and nuclear enzymes to various inhibitors were very similar. However, these two enzymes respond differently to heat and high ionic strength. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA polymerases
KW - ENZYMES
KW - NUCLEIC acids
KW - CATALYSTS
KW - CHROMATOGRAPHIC analysis
KW - CRYOSCOPY
N1 - Accession Number: 13483013; Zunino, Franco 1 Gambetta, Romolo 1 Colombo, Ambrogio 1 Luoni, Giuseppe 1 Zaccara, Adriano 1; Affiliation: 1: Division of Experimental Oncology B, National Cancer Institute, Milano; Source Info: Dec75 Part 2, Vol. 60 Issue 2, p495; Subject Term: DNA polymerases; Subject Term: ENZYMES; Subject Term: NUCLEIC acids; Subject Term: CATALYSTS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CRYOSCOPY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MILLER, Z.
AU - LOVELACE, E.
AU - GALLO, M.
AU - PASTAN, I.
T1 - Cyclic Guanosine Monophosphate and Cellular Growth.
JO - Science
JF - Science
Y1 - 1975/12/19/
VL - 190
IS - 4220
M3 - Article
SP - 1213
EP - 1215
SN - 00368075
AB - The addition of serum to nongrowing cells decreases cyclic guanosine monophosphate and cyclic adenosine monophosphate levels and promotes cell growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002935; MILLER, Z. 1; LOVELACE, E. 1; GALLO, M. 1; PASTAN, I. 1; Affiliations: 1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/19/1975, Vol. 190 Issue 4220, p1213; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2004-16189-020
AN - 2004-16189-020
AU - Thompson, Vaida D.
AU - Newman, Sidney H.
ED - Woods, Paul J.
ED - Woods, Paul J., (Ed)
T1 - Training and research opportunities in population psychology.
T2 - Career opportunities for psychologists.
Y1 - 1976///
SP - 232
EP - 248
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-03-9
N1 - Accession Number: 2004-16189-020. Partial author list: First Author & Affiliation: Thompson, Vaida D.; University of North Carolina at Chapel Hill, Department of Psychology, Chapel Hill, NC, US. Release Date: 20040809. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-03-9, Paperback. Language: English. Major Descriptor: Population; Professional Specialization; Psychologists. Minor Descriptor: Experimentation; History; Postgraduate Training; Behavioral Ecology. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 17.
AB - The goal of this chapter is to convey to young psychologists--and to those planning to become psychologists--the need for research that will contribute more fully to an understanding of population and population-related behaviors, which pertain to some of the most important problems in the world. In addition, we delineate ways in which interested students and psychologists can educate and develop themselves for working in the population field, still a relatively new field for psychologists. The most advantageous first step in becoming a population psychologist is to find a mentor whose own research interests are in population. There is an ever-increasing number of such persons, and their counsel may be sought. Even a student currently being trained with no focus on population issues or related research can learn about the issues, can ultimately focus on these issues in research, and can possibly find postdoctoral training and research support to further these goals. This chapter is thus directed toward three major topics: What are the areas and issues of research in population psychology? How can psychology trainees prepare themselves for work in this area? What postdoctoral training and research support opportunities may assist them toward their goals? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychologists
KW - population psychology
KW - professional specialization
KW - behavioral ecology
KW - research
KW - postdoctoral training
KW - history
KW - 1976
KW - Population
KW - Professional Specialization
KW - Psychologists
KW - Experimentation
KW - History
KW - Postgraduate Training
KW - Behavioral Ecology
KW - 1976
DO - 10.1037/10526-020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16189-020&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Dietz, W. H.
AU - Porcell, O.
AU - Moon, T. E.
AU - Peters, C. J.
AU - Purcell, R. H.
T1 - IgM levels and IgM-mediated immune responses in patients with acute hepatitis A, acute hepatitis b and chronic HB antigenaemia.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/01//
VL - 23
IS - 1
M3 - Article
SP - 69
EP - 72
PB - Wiley-Blackwell
SN - 00099104
AB - Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A. acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed in both types of acute hepatitis, but not in chronic hepatitis B antigenaemia. There was no correlation of the IgM level with either the prevalence or titre of any IgM-mediated immune response studied. These data suggest that the IgM elevations in both types of hepatitis may reflect virus-specific IgM synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN M
KW - IMMUNE response
KW - IMMUNOLOGY
KW - AGGLUTININS
KW - HEPATITIS B
KW - LIVER diseases
KW - RHEUMATOID arthritis
N1 - Accession Number: 15985071; Dietz, W. H. 1 Porcell, O. 1 Moon, T. E. 1 Peters, C. J. 1 Purcell, R. H. 2; Affiliation: 1: Gorgas Memorial Institute--Middle America 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland U.S.A.; Source Info: Jan1976, Vol. 23 Issue 1, p69; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: AGGLUTININS; Subject Term: HEPATITIS B; Subject Term: LIVER diseases; Subject Term: RHEUMATOID arthritis; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Kleinman, L. M.;
AU - Davignon, J. P.;
AU - Cradock, J. C.;
AU - Penta, J. S.;
AU - Slavik, M.;
T1 - Investigational drug information
CT - Investigational drug information
JO - Drug Intell. Clin. Pharm.
JF - Drug Intell. Clin. Pharm.
Y1 - 1976/01/01/
VL - 10
IS - Jan
SP - 48
EP - 49
AD - Cancer Therapy Evaluation Program, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-5252; Language: English; Trade Name: NSC-13875--NSC-45388--NSC-409962--Imidazole carboxamide--Dimethyltriazeno imidazole carboxamide; Generic Name: Hexamethylmelamine; Dacarbazine; Carmustine; Dacarbazine; Dacarbazine; Chemical Name: Dacarbazine--4342-03-4 Carmustine--154-93-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents hexamethylmelamine (10:00); AHFS Class: Antineoplastic agents dacarbazine (10:00); AHFS Class: Antineoplastic agents carmustine; References: 12; Journal Coden: DICPBB; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: D. R. Tousignaut
N2 - Monographs on hexamethylmelamine (HXM, NSC-13875, HMM), dacarbazine (DTIC, DIC, imidazole carboxamide, NSC-45388, dimethyltriazeno imidazole carboxamide) and carmustine (BCNU, NSC-409962) including description, storage pharmacology and mechanism of action, structure, preparation, route of administration, suggested dose, and use or purpose of investigation are presented.
KW - Hexamethylmelamine--monographs-;
KW - Dacarbazine--monographs-;
KW - Carmustine--monographs-;
KW - Antineoplastic agents--hexamethylmelamine--monographs;
KW - Antineoplastic agents--dacarbazine--monographs;
KW - Antineoplastic agents--carmustine--monographs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schweitzer, Stuart O.
T1 - Unemployment in the Urban Core: An Analysis of Thirty Cities with Policy Recommendations (Book Review).
JO - ILR Review
JF - ILR Review
Y1 - 1976/01//
VL - 29
IS - 2
M3 - Book Review
SP - 291
EP - 293
PB - Sage Publications Inc.
SN - 00197939
AB - The article reviews the book "Unemployment in the Urban Core: An Analysis of Thirty Cities with Policy Recommendations," by Stanley L. Friedlander.
KW - UNEMPLOYMENT
KW - NONFICTION
KW - FRIEDLANDER, Stanley L.
KW - UNEMPLOYMENT in the Urban Core: An Analysis of Thirty Cities With Policy Recommendations (Book)
N1 - Accession Number: 4456165; Schweitzer, Stuart O. 1; Affiliations: 1: Fogarty International Center for Advanced Studies, National Institutes of Health, Bethesda, Maryland; Issue Info: Jan76, Vol. 29 Issue 2, p291; Thesaurus Term: UNEMPLOYMENT; Subject Term: NONFICTION; Reviews & Products: UNEMPLOYMENT in the Urban Core: An Analysis of Thirty Cities With Policy Recommendations (Book); People: FRIEDLANDER, Stanley L.; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Pizzo, P. A.;
AU - Henderson, E. S.;
AU - Leventhal, B. G.;
T1 - Acute myelogenous leukemia in children: a preliminary report of combination chemotherapy
CT - Acute myelogenous leukemia in children: a preliminary report of combination chemotherapy
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1976/01/01/
VL - 88
IS - Jan
SP - 125
EP - 130
SN - 00223476
AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-6133; Language: English; Chemical Name: Prednisolone--50-24-8 Vincristine--57-22-7 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Cytarabine--147-94-4 Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents prednisolone (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents cytarabine (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 34; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Robert Harrison
N2 - Twenty-four randomly selected children (2 to 21 yr) with acute myelogenous leukemia were treated with single combination or alternating chemotherapy. Patients received prednisolone (I), vincristine (II), methotrexate, and mercaptopurine (POMP) or I, II, cytarabine, and daunorubicin (PRAVD) or alternating courses. Seventeen patients achieved complete remission, with those patients receiving POMP alone achieving the longest median duration of remission (1,400 days) when compared with PRAVD alone (395 days) and POMP-PRAVD combination (270 days). Fifteen of the 17 patients who had achieved remission eventually relapsed. The favorable initial response warrants further investigation of optimal maintenance schedules for treating acute myelogenous leukemia once remission has occurred.
KW - Prednisolone--combined therapy-;
KW - Vincristine--combined therapy-;
KW - Methotrexate--combined therapy-;
KW - Mercaptopurine--combined therapy-;
KW - Cytarabine--combined therapy-;
KW - Daunorubicin--combined therapy-;
KW - Antineoplastic agents--prednisolone--combined therapy, acute myelogenous leukemia, in children;
KW - Antineoplastic agents--vincristine--combined therapy, acute myelogenous leukemia, in children;
KW - Antineoplastic agents--methotrexate--combined therapy, acute myelogenous leukemia, in children;
KW - Antineoplastic agents--mercaptopurine--combined therapy, acute myelogenous leukemia, in children;
KW - Antineoplastic agents--cytarabine--combined therapy, acute myelogenous leukemia, in children;
KW - Antineoplastic agents--daunorubicin--combined therapy, acute myelogenous leukemia, in children;
KW - Combined therapy--antineoplastic agents--leukemias, acute myelogenous, in children;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6133&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pizzo, P. A.;
AU - Bleyer, W. A.;
AU - Poplack, D. G.;
AU - Leventhal, B. G.;
T1 - Reversible dementia temporally associated with intraventricular therapy with methotrexate in a child with acute myelogenous leukemia
CT - Reversible dementia temporally associated with intraventricular therapy with methotrexate in a child with acute myelogenous leukemia
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1976/01/01/
VL - 88
IS - Jan
SP - 131
EP - 133
SN - 00223476
AD - Pediatric Oneology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-4498; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 19; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - A case report of reversible dementia in a child with acute myelogenous leukemia receiving maintenance intraventricular methotrexate (I) (12 ng/sq m) is presented. CSF levels of I were in the nontoxic range and neurological evaluation failed to demonstrate anatomical obstruction, infection, or folate depletion. The patient's symptoms gradually subsided when I was discontinued suggesting that I neurotoxicity may occur in the absence of an elevated CSF concentration of I.
KW - Methotrexate--adverse reactions-;
KW - Drugs, adverse reactions--methotrexate--dementia, in child;
KW - Antineoplastic agents--methotrexate--adverse reactions, dementia, in child;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Narin, Francis
AU - Pinski, Gabriel
AU - Gee, Helen Hofer
T1 - Structure of the Biomedical Literature.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1976/01//
VL - 27
IS - 1
M3 - Article
SP - 25
EP - 45
SN - 00028231
AB - The structure and interrelations of the biomedical journal literature are investigated as a preparatory step for studies of biomedical research activity. Using newly developed methods of bibliographic citation analysis, approximately 900 biomedical journals are classified into approximately 50 separate fields and into four research levels. The research-level scale indicates research orientation ranging from clinical observation to basic research. Measures of influence are then obtained for individual journals, for biomedical fields and for research levels. The fields of biochemistry and physiology are shown to have the highest citation influence. A hierarchical influence diagram is presented to display the influence of 42 fields within biomedicine. Hierarchical influence diagrams are also presented for several individual fields showing the influence structure and citation relationships among their component journals. The combination of a subject, a level and an influence measure provides a unified framework for planned research activity analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL literature
KW - MEDICAL sciences
KW - PHYSIOLOGY
KW - PERIODICALS
KW - BIOCHEMISTRY
KW - MEDICAL research
N1 - Accession Number: 16755261; Narin, Francis 1; Pinski, Gabriel 1; Gee, Helen Hofer 2; Affiliations: 1: Computer Horizons, Inc. Cherry Hill, NJ 08034.; 2: Division of Program Analysis National Institutes of Health Bethesda, MD 20014.; Issue Info: Jan1976, Vol. 27 Issue 1, p25; Subject Term: MEDICAL literature; Subject Term: MEDICAL sciences; Subject Term: PHYSIOLOGY; Subject Term: PERIODICALS; Subject Term: BIOCHEMISTRY; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Beaven, M. A.;
T1 - Histamine. Parts 1 and 2
CT - Histamine. Parts 1 and 2
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/01/01/
VL - 294
IS - Jan 1; Feb 5
SP - 30
EP - 25
SN - 00284793
AD - National Institutes of Health, Bldg. 10, Rm. 5N107, Bethesda, Maryland 20014
N1 - Accession Number: 13-3484; Language: English; Chemical Name: Histamine--51-45-6; References: 14; Journal Coden: NEJMAG; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Part one includes a discussion on the discovery of histamine and its actions; the nature of histamine stores in tissues: mast-cell and non-mast-cell histamine; release of histamine from mast cells; and the synthesis and metabolism of histamine. The classic antihistamines (H\IF/1\BS/ inhibitors), a second type of histamine receptor (H\IF/2\BS/ receptor) and the discovery of antagonists to these receptors, the role of histamine in gastric secretion, recent findings on the mechanism of histamine release in inflammation and immediate hypersensitivity reactions, recent developments in the assay of histamine and the possible role of histamine in the central nervous system are discussed in part 2.
KW - Histamine--pharmacology-;
KW - Antihistamines--pharmacology--discussion;
KW - Pharmacology--antihistamines--discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-42033-022
AN - 2013-42033-022
AU - Shore, Milton F.
T1 - Review of Adolescent psychiatry Volume II: Developmental and clinical studies and Adolescent psychiatry, Volume III: Developmental and clinical studies.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/01//
VL - 46
IS - 1
SP - 182
EP - 183
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42033-022. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Psychiatry; Family Therapy; Government Policy Making; Psychiatric Hospitalization. Minor Descriptor: Disadvantaged. Classification: Psychological Disorders (3210); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Reviewed Item: Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). Adolescent psychiatry volume II: Developmental and clinical studies=450 pp. $15.00. Basic Books, New York; 1973. Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). Adolescent psychiatry volume III: Develomental and clinical studies=456 pp. $17.50. Basic Books, New York; 1974. Page Count: 2. Issue Publication Date: Jan, 1976.
AB - Reviews the books, Adolescent Psychiatry Volume II: Developmental and Clinical Studies edited by Sherman C. Feinstein and Peter L. Giovacchini (1973) and Adolescent Psychiatry Volume III: Developmental and Clinical Studies edited by Sherman C. Feinstein and Peter L. Giovacchini (1974). Included are chapters on medical settings; family therapy; the disadvantaged adolescent; psychiatric hospitalization; war and youth; delinquency and violence. The clinical articles still comprise the majority of chapters. Although they are often exciting, they sometimes appear too short or seem to resemble lectures that were transferred to print, rather than scholarly articles. The authors have posed the challenge for the future volumes of this series. From the development of this set of volumes, it appears more and more possible that the editors may rise to the challenge in the future with articles on prevention, on the mentally retarded adolescent, on the brain damaged adolescent. and on the abused adolescent, as well as more substantive articles on those economic. cultural. and social factors that must be understood if we are indeed to develop programs that can go beyond the repetition of stock phrases towards practical and sophisticated suggestions for a well planned national social policy for youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent psychiatry
KW - psychiatric hospitalization
KW - medical settings
KW - family therapy
KW - disadvantaged adolescents
KW - social policy
KW - 1976
KW - Adolescent Psychiatry
KW - Family Therapy
KW - Government Policy Making
KW - Psychiatric Hospitalization
KW - Disadvantaged
KW - 1976
U2 - Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). (1973); Adolescent psychiatry volume II: Developmental and clinical studies; 450 pp. $15.00. Basic Books, New York
U2 - Feinstein, Sherman C. (Ed); Giovacchini, Peter L. (Ed). (1974); Adolescent psychiatry volume III: Develomental and clinical studies; 456 pp. $17.50. Basic Books, New York
DO - 10.1037/h0098744
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42033-022&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05515-005
AN - 2009-05515-005
AU - Kety, Seymour S.
AU - Rosenthal, David
AU - Wender, Paul H.
AU - Schulsinger, Fini
T1 - Studies based on a total sample of adopted individuals and their relatives: Why they were necessary, what they demonstrated and failed to demonstrate.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1976///
VL - 2
IS - 3
SP - 413
EP - 428
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Kety, Seymour S., Psychiatric Research Laboratories, Harvard Medical School, Massachusetts General Hospital, Boston, MA, US, 02114
N1 - Accession Number: 2009-05515-005. PMID: 1006193 Partial author list: First Author & Affiliation: Kety, Seymour S.; Harvard Medical School, Cambridge, MA, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Environmental Effects; Etiology; Genetics; Schizophrenia. Minor Descriptor: Adoption (Child); Family; Twins. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: 1976.
AB - Studies of adopted individuals and their biological and adoptive families offer a means of disentangling the genetic and environmental contributions to a disorder such as schizophrenia and permit an examination of the effects of one type of influence while the other is randomized or controlled. Using this strategy in a series of studies, we have obtained results pertinent to genetic and family-interaction theories of etiology in a considerably lesser degree to the confounding of these influences that have flawed previous studies in both fields. There is every reason that these studies should be presented and criticized in an issue of the Schizophrenia Bulletin devoted to genetics, just as another strategy—high risk studies—was previously examined. This article focuses on two such cases: A view of adoption studies from the twin study vantage point—the critique by Gottesman and Shields; A view of adoption studies through the holes of a 'tightly knit theory' of parental deviance—the critique by Lidz. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adoption studies
KW - twin studies
KW - genetic contributions
KW - environmental contributions
KW - schizophrenia
KW - 1976
KW - Environmental Effects
KW - Etiology
KW - Genetics
KW - Schizophrenia
KW - Adoption (Child)
KW - Family
KW - Twins
KW - 1976
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program. Recipients: No recipient indicated
U1 - Sponsor: Scottish Rite Schizophrenia Research Program. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: MH 15602; MH 25515. Recipients: No recipient indicated
DO - 10.1093/schbul/2.3.413
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05515-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Appelbaum, F. R.;
AU - Strauchen, J. A.;
AU - Graw, R. G.;
AU - Savage, D. D.;
AU - Kent, D. M.;
AU - \ET/;
T1 - Acute lethal carditis caused by high dose combination chemotherapy
CT - Acute lethal carditis caused by high dose combination chemotherapy
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/01/10/
VL - 1
IS - Jan 10
SP - 58
EP - 62
SN - 00237507
AD - Bldg. 10, Rm. 3B14, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 13-3039; Language: English; Trade Name: Bis-chloroethyl nitrosurea--Cytosine arabinoside; Generic Name: Carmustine; Cytarabine; Chemical Name: Carmustine--154-93-8 Cytarabine--147-94-4 Cyclophosphamide--6055-19-2 Thioguanine--154-42-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents carmustine (10:00); AHFS Class: Antineoplastic agents cytarabine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents thioguanine; References: 18; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Investigational Drugs
N2 - An acute lethal myopericarditis was observed in 4 out of 15 patients receiving the BACT regimen consisting of bis-chloroethyl nitrosourea (carmustine), cytosine arabinoside (cytarabine), cyclophosphamide and 6-thioguanine. In all cases the myopericarditis occurred 5-9 days after the initiation of chemotherapy, with dyspnea, tachycardia, orthostatic hypotension, fluid retention, decreased voltage on electrocardiography, and pericardial effusion documented by echocardiogram, and progressed in 2 to 6 days to a fatal low output state despite vigorous treatment. In 3 of the 4 patients, necropsy was permitted and revealed the unique pathological finding of fibrin microthrombi in capillaries, fibrin strands in the interstitium, and fibrin strands within the heart muscle cells.
KW - Carmustine--adverse reactions-;
KW - Cytarabine--adverse reactions-;
KW - Cyclophosphamide--adverse reactions-;
KW - Thioguanine--adverse reactions-;
KW - Drugs, adverse reactions--carmustine--myopericarditis, lethal, combined therapy, in patients;
KW - Drugs, adverse reactions--cytarabine--myopericarditis, lethal, combined therapy, in patients;
KW - Drugs, adverse reactions--cyclophosphamide--myopericarditis, lethal, combined therapy, in patients;
KW - Drugs, adverse reactions--thioguanine--myopericarditis, lethal, combined therapy, in patients;
KW - Combined therapy--antineoplastic agents--myopericarditis, lethal, in patients;
KW - Antineoplastic agents--carmustine--combined therapy, lethal myopericarditis, in patients;
KW - Antineoplastic agents--cytarabine--combined therapy, lethal myopericarditis, in patients;
KW - Antineoplastic agents--cyclophosphamide--combined therapy, lethal myopericarditis, in patients;
KW - Antineoplastic agents--thioguanine--combined therapy, lethal myopericarditis, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Slavik, M.;
AU - Muggia, F. M.;
T1 - Allergic reactions to cis platinum
CT - Allergic reactions to cis platinum
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/01/10/
VL - 1
IS - Jan 10
SP - 90
SN - 00237507
AD - Chemotherapy Evaluation Program and Investigational Drug Branch, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-3040; Language: English; Trade Name: NSC-119875; Generic Name: cis-Diaminedichloroplatinum; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cis-diaminedichloroplatinum; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Investigational Drugs; Abstract Author: Joan Lentine
N2 - Eight cases of anaphylactic-like reactions possibly secondary to cis-diaminedichloroplatinum (NSC-119875) administration are reported. The reactions consisted of facial edema, wheezing, tachycardia, and hypotension within a few min of IV drug administration. All reactions were controlled with IV adrenaline, corticosteroids, or antihistamines. All of these patients had received prior cis-platinum and all were receiving cis-platinum with various combinations of other chemotherapeutic agents.
KW - cis-Diaminedichloroplatinum--adverse reactions-;
KW - Drugs, adverse reactions--cis-diaminedichloroplatinum--anaphylaxis, in patients;
KW - Antineoplastic agents--cis-diaminedichloroplatinum--anaphylaxis, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3040&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MARTIN, JEANNE E.
AU - KLEIN, DAVID C.
T1 - Melatonin Inhibition of the Neonatal Pituitary Response to Luteinizing Hormone-Releasing Factor.
JO - Science
JF - Science
Y1 - 1976/01/23/
VL - 191
IS - 4224
M3 - Article
SP - 301
EP - 302
SN - 00368075
AB - Neonatal rat anterior pituitary glands treated in organ culture with I nanomolar luteinizing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with I nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85233124; MARTIN, JEANNE E. 1; KLEIN, DAVID C. 1; Affiliations: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/23/1976, Vol. 191 Issue 4224, p301; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEVIS, WILLIAM R.
AU - WHALEN, JOHN J.
AU - SHERINS, RICHARD J.
T1 - Mixed Cultures of Sperm and Leukocytes as a Measure of Histocompatibility in Man.
JO - Science
JF - Science
Y1 - 1976/01/23/
VL - 191
IS - 4224
M3 - Article
SP - 302
EP - 304
SN - 00368075
AB - Human peripheral blood leukocyte cultures containing varying numbers of washedfresh sperm were cultured for 4 days. [3H] Thymidine incorporation was used as a measure of lymphocyte transformation. Human sperm cells induce a 4- to 250-fold increase in [3H]thymidine incorporation in allogeneic leukocyte cultures, but no increase was demonstrated in autologous leukocyte cultures. The response was dose-dependent with maximum stimulation obtained at 2 × 106 sperm per milliliter of culture. Seminal plasma was inhibitory in a dose-dependent fashion and as little as 0.2 microliter per 200 microliters of culture was inhibitory. The data indicate that tissues other than leukocytes can express the portion of the major histocompatibility complex responsible for allospecific lymphocyte transformation, and thus may have application in transplantation and reproductive biology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85233125; LEVIS, WILLIAM R. 1; WHALEN, JOHN J. 1; SHERINS, RICHARD J. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 1/23/1976, Vol. 191 Issue 4224, p302; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Post, R. M.;
AU - Gerner, R. H.;
AU - Carman, J. S.;
AU - Bunney, W. E.;
T1 - Effects of low doses of a dopamine receptor stimulator in mania
CT - Effects of low doses of a dopamine receptor stimulator in mania
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/01/24/
VL - 1
IS - Jan 24
SP - 203
EP - 204
SN - 00237507
AD - Adult Psychiatry Branch, Section of Psychobiology, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 13-3098; Language: English; Trade Name: ET-495; Generic Name: Piribedil; Chemical Name: Piribedil--3605-01-4; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents piribedil; References: 15; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - Results of a preliminary trial in 2 manic patients showed that low oral doses of piribedil (ET-495) (60 mg/day) may produce antimanic effects.
KW - Piribedil--mania-;
KW - Psychotherapeutic agents--piribedil--mania, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - LENEVEU, D. M.
AU - RAND, R. P.
AU - GINGELL, D.
AU - PARSEGIAN, V. A.
T1 - Apparent Modification of Forces Between Lecithin Bilayers.
JO - Science
JF - Science
Y1 - 1976/01/30/
VL - 191
IS - 4225
M3 - Article
SP - 399
EP - 400
SN - 00368075
AB - Small sugar solutes effect variation in the equilibrium separation of lecithin bilayers in aqueous solution. Since sugars have negligible influence on bilayer structure, they probably act by modifying inrterbilayerforces. The observed widening and narrowing of the bilayer separation is correlated with the predicted weakening and strengthening of the attractive van der Waals forces between lipid bilayers that occurs with increasingsugar concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219638; LENEVEU, D. M. 1; RAND, R. P. 1; GINGELL, D. 2; PARSEGIAN, V. A. 3; Affiliations: 1: Brock University, St. Catharines, Ontario, Canada L2S 3A I; 2: Middlesex Hospital Medical School, London, England WIP 7PN; 3: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/30/1976, Vol. 191 Issue 4225, p399; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Ross, G. T.;
T1 - Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms
CT - Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1976/02/01/
VL - 37
IS - Feb
SP - 1043
EP - 1047
AD - Reproduction Research Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-0386; Language: English; References: 16; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Michael A. Eldon
N2 - Use of therapeutic alternatives in treatment of gestational trophoblastic neoplasms can retain reproductive potential of women even after exposure to potential teratogenic agents. Fifty-eight women who conceived following successful chemotherapy of gestational trophoblastic neoplasms subsequently became pregnant a total of 96 times. Of the 96 pregnancies, 78 terminated in liveborn infants. Fifteen ended in abortion and 3 terminated with stillborn infants. Among the liveborn and stillborn infants there were 3 with congenital malformations classified as major. While this incidence of congenital malformations does not appear to be increased over that expected, the numbers are too small to perceive a 2-fold increase in the expected incidence. Suggestions are made for improvement in the quality of these data.
KW - Antineoplastic agents--teratogenicity--anomalies, congenital, following maternal therapy for trophoblastic neoplasms;
KW - Teratogenicity--antineoplastic agents--anomalies, congenital, following maternal therapy for trophoblastic neoplasms;
KW - Toxicity--antineoplastic agents--teratogenicity, congenital anomalies, following maternal therapy for trophoblastic neoplasms;
KW - Placental transfer--antineoplastic agents--teratogenicity, congenital anomalies, following maternal therapy for trophoblastic neoplasms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hoover, R. N.;
T1 - Bacillus Calmette-Guerin vaccination and cancer prevention: a critical review of the human experience
CT - Bacillus Calmette-Guerin vaccination and cancer prevention: a critical review of the human experience
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1976/02/01/
VL - 36
IS - Feb
SP - 652
EP - 654
SN - 00085472
AD - Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-3965; Language: English; References: 19; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Studies of the cancer experiences of children vaccinated with BCG vaccines in antituberculosis programs were reviewed and the strengths and weaknesses of each evaluated. There is little evidence that vaccination outside of the neonatal period is effective. If there is an effect of neonatal vaccination, it must convey only a small amount of protection. Follow-up studies adequate to assess the long term effects of such vaccination, particularly the risk of lymphoma, have not been done, and recent evidence indicates that such evaluation is warranted.
KW - BCG vaccines--cancer-;
KW - Immunotherapy--BCG vaccines--cancer, prevention, discussion, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smyth, A. C.;
AU - Wiernik, P. H.;
T1 - Combination chemotherapy of adult acute lymphocytic leukemia
CT - Combination chemotherapy of adult acute lymphocytic leukemia
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1976/02/01/
VL - 19
IS - Feb
SP - 240
EP - 245
SN - 00099236
AD - Section of Medical Oncology, National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
N1 - Accession Number: 14-1697; Language: English; Chemical Name: Thioguanine--154-42-7 Vincristine--57-22-7 Dexamethasone--50-02-2 Pyrimethamine--58-14-0 Lomustine--13010-47-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents thioguanine (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents dexamethasone (10:00); AHFS Class: Antineoplastic agents pyrimethamine (10:00); AHFS Class: Antineoplastic agents lomustine; References: 22; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Seventeen adults with previouly untreated acute lymphocytic leukemia received thioguanine, vincristine, dexamethasone (I), and pyrimethamine for remission induction. Nine patients (53%) achieved complete and 5 (30%) partial remissions. Once in complete remission patients were given 2 closely separated consolidation courses followed by monthly maintenance courses of the same regimen with the addition of lomustine every other month during maintenance therapy. The median duration of complete remission was 176 days (range 38 to 605). The median survival for all patients was 405 days (range 30 to 1,058). Oral pyrimethamine and lomustine were used for their potential activity as prophylactics against meningeal leukemia. I was used instead of prednisone because of the potential enhancement of granulocyte mobilization by the former. Six patients (35%) developed meningeal leukemia while on initial induction or maintenance therapy, 5 within 6 months of diagnosis. Life threatening infections occurred in 10 patients (59%) during induction. Whereas the regimen effectively induced complete remission in about half of previously untreated adults, it was not effective in maintenance. The incidence of meningeal leukemia and infection during induction was high. Pyrimethamine was inadequate prophylaxis for meningeal leukemia; I did not reduce the incidence of serious infection.
KW - Thioguanine--dexamethasone, pyrimethamine and vincristine-;
KW - Vincristine--dexamethasone, pyrimethamine and thioguanine-;
KW - Dexamethasone--pyrimethamine, thioguanine and vincristine-;
KW - Pyrimethamine--dexamethasone, thioguanine and vincristine-;
KW - Lomustine--combined therapy-;
KW - Toxicity--antineoplastic agents--combined therapy, meningeal leukemia and infections, patients;
KW - Combined therapy--antineoplastic agents--leukemias, acute lymphocytic, therapy, patients;
KW - Antineoplastic agents--thioguanine--combined therapy, acute lymphocytic leukemia, patients;
KW - Antineoplastic agents--vincristine--combined therapy, acute lymphocytic leukemia, patients;
KW - Antineoplastic agents--dexamethasone--combined therapy, acute lymphocytic leukemia, patients;
KW - Antineoplastic agents--pyrimethamine--combined therapy, acute lymphocytic leukemia, patients;
KW - Antineoplastic agents--lomustine--combined therapy, acute lymphocytic leukemia, maintenance, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Shellow, R.;
T1 - Drug abuse and crime: fact or fancy?
CT - Drug abuse and crime: fact or fancy?
JO - Contemporary Drug Problems (USA)
JF - Contemporary Drug Problems (USA)
Y1 - 1976/02/01/
VL - 5
IS - Feb
SP - 131
EP - 147
SN - 00914509
AD - National Institute on Drug Abuse, Washington, D.C.
N1 - Accession Number: 14-4597; Language: English; References: 30; Journal Coden: CDGPAI; Section Heading: Sociology, Economics and Ethics; Abstract Author: D. L. Thompson
N2 - Research needs related to the relationship between criminal behavior and drug use are discussed with reference to the work of the Panel on Drug Use and Criminal Behavior convened by the National Institute of Drug Abuse.
KW - Drug abuse--and crime--relationships, research needs;
KW - Crime--and drug abuse--relationships, research needs;
KW - Research--drug abuse--relationships, crime;
KW - Sociology--drug abuse--and crime, relationships, research needs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - DuPont, R. L.;
T1 - Future of Federal drug abuse research. How can we best maximize scarce resources?
CT - Future of Federal drug abuse research. How can we best maximize scarce resources?
JO - Drug Alcohol Depend.
JF - Drug Alcohol Depend.
Y1 - 1976/02/01/
VL - 1
IS - Feb
SP - 233
EP - 240
AD - National Institute on Drug Abuse, Rockville, Maryland
N1 - Accession Number: 14-0906; Language: English; Journal Coden: DADEDV; Section Heading: Sociology, Economics and Ethics
N2 - Presented, are some of the accomplishments and longer range objectives of the government's drug abuse research effort, and the problems with which they are now confronted.
KW - Research--drug abuse--United States, government programs;
KW - Drug abuse--research--United States, government programs;
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DP - EBSCOhost
DB - ipa
ER -
TY - NEWS
AU - Brown, Bertram S.
T1 - How do mental health and aging affect each other? New center will encourage search for answers.
JO - Geriatrics
JF - Geriatrics
Y1 - 1976/02//
VL - 31
IS - 2
M3 - Editorial
SP - 40
EP - 44
SN - 0016867X
N1 - Accession Number: 17208317; Brown, Bertram S. 1,2; Source Information: Feb1976, Vol. 31 Issue 2, p40; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1383
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Huxley, M.;
T1 - Criteria for a socially sanctionable drug
CT - Criteria for a socially sanctionable drug
JO - Interdisciplinary Sci. Rev.
JF - Interdisciplinary Sci. Rev.
Y1 - 1976/02/01/
VL - 1
IS - Feb
SP - 176
EP - 182
AD - National Institute of Mental Health, Washington, D.C. 20852
N1 - Accession Number: 14-2148; Language: English; References: 15; Section Heading: Sociology, Economics and Ethics
N2 - In all recorded history, including accounts of preliterate peoples, there is irrefutable evidence that in practically every culture and every society man has developed techniques or found mechanisms whose psychological, physiological and biological effects have permitted him temporarily to alter the state of this consciousness and thereby escape a world that seems all too present, all too humdrum, all too much with him. The occasional need to alter his state of consciousness appears to be one of man's basic drives. These alterations\M/which must be clearly different by an order of magnitude from man's normal experience and expectations\M/involve one or more of man's senses, his conceptual, cognitive and ideational processes, his mood and emotions, and the integrative functions of his mind. That these alterations appear to be a basic need for psychic release can be seen in the enormous range and variety of the psychobiological consciousness-changing techniques and mechanisms that have been developed and explored, and the multiplicity of purposes to which they have been put. Their very existence is a testament to the efficacy of man's ability to satisfy this need.
KW - Sociology--drugs--criteria, for a socially sanctionable drug;
KW - Psychotherapeutic agents--sociology--criteria, for a socially sanctionable drug;
KW - Research--psychotherapeutic agents--criteria, for a socially sanctionable drug;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06283-024
AN - 2006-06283-024
AU - Yarrow, Leon J.
T1 - The Mechanisms of Deprivation.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1976/02//
VL - 21
IS - 2
SP - 126
EP - 127
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06283-024. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childrearing Attitudes; Childrearing Practices; Mothers; Parental Attitudes; Parental Characteristics. Minor Descriptor: Childhood Development. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Rutter, Michael. The Qualities of Mothering: Maternal Deprivation Reassessed=New York: Aronson, 1974. Pp. 175. $7.50; 1974. Page Count: 2. Issue Publication Date: Feb, 1976.
AB - Reviews the book, The Qualities of Mothering: Maternal Deprivation Reassessed by Michael Rutter (1974). This slim volume was first published in paperback in 1972; apparently after the paperback supply was exhausted, it was reprinted in hardcover at several times the original cost. The discussion is organized around six chapters dealing with three broad issues: the qualities of mothering necessary for normal development; the short-term effects of maternal deprivation; and the long-term consequences of deprivation. This last topic is dealt with in two chapters, one on modifying factors and the other subtitled 'possible mechanisms.' The review of the literature is selective and the bases for selection are never specified. For example, although there are 26 pages of bibliography, there is no mention of Spitz and Wolf's classic papers or Fairbairn's theoretical discussion of object relationships. As it is, this volume helps us take stock of what has been accomplished in the past 25 years; the advances are not negligible. It also serves as a reminder that there are still many questions to be resolved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal deprivation
KW - mothering
KW - normal development
KW - 1976
KW - Childrearing Attitudes
KW - Childrearing Practices
KW - Mothers
KW - Parental Attitudes
KW - Parental Characteristics
KW - Childhood Development
KW - 1976
U2 - Rutter, Michael. (1974); The Qualities of Mothering: Maternal Deprivation Reassessed; New York: Aronson, 1974. Pp. 175. $7.50
DO - 10.1037/014946
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SAAVEDRA, JUAN M.
AU - GROBECKER, HORST
AU - AXELROD, JULIUS
T1 - Adrenaline-Forming Enzyne in Brainstem: Elevation in Genetic and Experimental Hypertension.
JO - Science
JF - Science
Y1 - 1976/02/06/
VL - 191
IS - 4226
M3 - Article
SP - 483
EP - 484
SN - 00368075
AB - The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1, and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1, region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219693; SAAVEDRA, JUAN M. 1; GROBECKER, HORST 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 6/1976, Vol. 191 Issue 4226, p483; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSTEIN, JOHN N.
AU - LEITZ, FRANK B.
T1 - Electric Power from Differences in Salinity: The Dialytic Battery.
JO - Science
JF - Science
Y1 - 1976/02/13/
VL - 191
IS - 4227
M3 - Article
SP - 557
EP - 559
SN - 00368075
AB - An array of alternating anion and cation exchange membranes can be used to generate electric power from the free energy of mixing of river and sea waters. A simple mathematical model, which predicts experimental results well, is useful in exploring conditions for optimization of the process. Major, but not impossible, improvements in technology would be required to bring the cost of power from the dialytic battery into line with foreseeable energy prices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219721; WEINSTEIN, JOHN N. 1; LEITZ, FRANK B. 2; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Bureau of Reclamation, Department of the Interior, Denver, Colorado 80225; Issue Info: 2/13/1976, Vol. 191 Issue 4227, p557; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Di Natale, Paola
AU - Schechter, Alan N.
AU - Lepore, Giuseppina Castronuov
AU - De Lorenzo, Francesco
T1 - Histidyl Transfer Ribonucleic Acid Synthetase from Salmonella typhimurium.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/02/15/Feb76 Part 2
VL - 62
IS - 2
M3 - Article
SP - 293
EP - 298
PB - Wiley-Blackwell
SN - 00142956
AB - Structural requirements for substrate binding to histidyl-tRNA synthetase from Salmonella typhimurium have been investigated using ATP analogues. K; values and the relative binding affinity of the enzyme for these analogues have been determined in the tRNA aminoacylation reaction. The enzyme is highly specific for ATP: no binding was found for GTP, CTP, TTP and UTP. dATP is a very poor substrate for acylation of tRNA, with a Km 40-fold higher than that of ATP. Binding of adenosine 5′-triphosphate requires interactions of the amino group of adenosine and the sugar moiety; the 2′ and the 5′ positions of the ribose appear to be essential for recognition; the phosphate groups enhance the binding. AMP is a noncompetitve inhibitor with ATP. The interaction of histidyl-tRNA synthetase, a dimeric enzyme, with histidine and ATP was examined by fluorescence measurements at equilibrium and by equilibrium dialysis. Binding with L-histidine is significantly tighter at pH 6 than at pH 7, while the ATP binding is independent of pH. The stoichiometry was measured at pH 7.5 by equilibrium dialysis and is 1 moI ATP/mol enzyme and, variably, close to 2 or 1 mol histidine/mol enzyme. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN binding
KW - LIGASES
KW - SALMONELLA typhimurium
KW - ADENOSINE triphosphate
KW - RIBOSE
KW - BIOCHEMISTRY
N1 - Accession Number: 13488290; Di Natale, Paola 1 Schechter, Alan N. 1 Lepore, Giuseppina Castronuov 1 De Lorenzo, Francesco 1; Affiliation: 1: 2nd Chair of Biochemistry, 2nd Medical School, University of Naples and the Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Feb76 Part 2, Vol. 62 Issue 2, p293; Subject Term: PROTEIN binding; Subject Term: LIGASES; Subject Term: SALMONELLA typhimurium; Subject Term: ADENOSINE triphosphate; Subject Term: RIBOSE; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Fauci, A. S.;
AU - Dale, D. C.;
AU - Balow, J. E.;
T1 - Glucocorticosteroid therapy: mechanisms of action and clinical considerations
CT - Glucocorticosteroid therapy: mechanisms of action and clinical considerations
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/03/01/
VL - 84
IS - Mar
SP - 304
EP - 315
SN - 00034819
AD - National Institute of Allergy and Infectious Diseases, Bldg. 10, Room 11 B-09, NIH, Bethesda, Maryland 22014
N1 - Accession Number: 13-4975; Language: English; References: 129; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Charles D. Ponte
N2 - Current concepts regarding glucocorticosteroids (I) and their use in clinical medicine today, are reviewed, along with explanations of their mechanism of action. I and their effect on granulocyte kinetics and function were discussed. Their effect on the distribution pattern of circulating mononuclear cells and their function is also presented. Finally the clinical use of I and the inherent risk of infectious complications were discussed.
KW - Steroids, cortico---therapy--and mechanism of action, review;
KW - Mechanism of action--steroids, cortico---and therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Prescott, James W.
T1 - Violence, pleasure and religion.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1976/03//
VL - 32
IS - 3
M3 - Letter
SP - 62
EP - 62
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21595886; Prescott, James W. 1; Affiliation: 1: National Institute of Child Health and Human Development, Bethesda, Maryland; Source Info: Mar1976, Vol. 32 Issue 3, p62; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yarrow, Marian Radke
AU - Waxler, Carolyn Zahn
AU - Barrett, David
AU - Darby, Jean
AU - King, Robert
AU - Pickett, Marilyn
AU - Smith, Judith
T1 - Dimensions and Correlates of Prosocial Behavior in Young Children.
JO - Child Development
JF - Child Development
Y1 - 1976/03//
VL - 47
IS - 1
M3 - Article
SP - 118
EP - 125
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12432721; Yarrow, Marian Radke 1 Waxler, Carolyn Zahn 1 Barrett, David 1 Darby, Jean 1 King, Robert 1 Pickett, Marilyn 1 Smith, Judith 1; Affiliation: 1: National institute of Mental Health.; Source Info: Mar1976, Vol. 47 Issue 1, p118; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1467-8624.ep12432721
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Halverson Jr., Charles F.
AU - Victor, James B.
T1 - Minor Physical Anomalies and Problem Behavior in Elementary School Children.
JO - Child Development
JF - Child Development
Y1 - 1976/03//
VL - 47
IS - 1
M3 - Article
SP - 281
EP - 285
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12432745; Halverson Jr., Charles F. 1 Victor, James B. 2; Affiliation: 1: National Institute of Mental Health. 2: State University of New York, Albany.; Source Info: Mar1976, Vol. 47 Issue 1, p281; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1467-8624.ep12432745
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12432745&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Federman, Edward J.
AU - Yang, Raymond K.
T1 - A Critique of "Obstetrical Pain-relieving Drugs as Predictors of Infant Behavior Variability"
JO - Child Development
JF - Child Development
Y1 - 1976/03//
VL - 47
IS - 1
M3 - Article
SP - 294
EP - 296
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12432748; Federman, Edward J. 1 Yang, Raymond K. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Mar1976, Vol. 47 Issue 1, p294; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1467-8624.ep12432748
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirkpatrick, C. H.
AU - Ottenson, E. A.
AU - Smith, T. K.
AU - Wells, S. A.
AU - Burdick, J. F.
T1 - Reconstitution of defective cellular immunity with foetal thymus and dialysable transfer factor.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/03//
VL - 23
IS - 3
M3 - Article
SP - 414
EP - 428
PB - Wiley-Blackwell
SN - 00099104
AB - Extensive studies of a 9-year-old boy with recurrent pulmonary infections and chronic mucocutaneous candidiasis disclosed a severe defect in cell-mediated immunity but normal humoral immune responses. These immunological detects were not improved by initial treatment with transfer factor. Alter receiving a foetal thymus transplant the patient developed positive delayed-type skin tests, could be sensitized with chlorodinitrobenzene, and showed progressive improvement of in vitro lymphocyte functions including spontaneous formation of rosettes with sheep erythrocytes and positive responses to photohaemagglutinin, concanavalin A and allogeneic leucocytes. Moreover, lymph node cellularity increased, especially in the thymus-dependent zones. Though the in vitro responses persisted for over 1 year, skin tests became Unreactive at 38 weeks. However, in contrast to the pre-transplant experience transfer factor was now effective in inducing positive skin tests. These studies provide a chronological account of the effect of the thymus on expression of lymphocyte-mediated immune responses in man and suggest that thymus-derived cells are required for acquisition of transfer factor-induced cellular immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOCRINE glands
KW - LYMPHOID tissue
KW - IMMUNITY
KW - IMMUNOLOGY
KW - BLOOD cells
KW - LEUCOCYTES
N1 - Accession Number: 15985291; Kirkpatrick, C. H. 1,2 Ottenson, E. A. 1,2 Smith, T. K. 1,2 Wells, S. A. 1,2 Burdick, J. F. 1,2; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A. 2: Infectious Diseases and Surgery Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p414; Subject Term: ENDOCRINE glands; Subject Term: LYMPHOID tissue; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: BLOOD cells; Subject Term: LEUCOCYTES; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyler, D. J.
T1 - Peripheral lymphocyte subpopulations in human falciparum malaria.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/03//
VL - 23
IS - 3
M3 - Article
SP - 471
EP - 476
PB - Wiley-Blackwell
SN - 00099104
AB - The concentration of circulating T, B. and 'null' lymphocytes was determined in thirty children and three adults with Plasmodium falciparum infections in West Africa. During infection, both percentage as well as concentration of T cells were decreased as compared to levels following treatment. The percentage but not concentration of B cells was increased. Both percentage and concentration of 'null' cells were increased in malaria. Patients with splenomegaly had the most severe alterations in T-cell number; no other historic or clinical parameter correlated with the degree or pattern of change in circulating lymphocyte sub populations. These alterations were rapidly reversible after anti malarial treatment and presumably represent the sequestration of I cells in the spleen or other organs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - PLASMODIUM falciparum
KW - PATIENTS
KW - T cells
KW - PROTOZOAN diseases
N1 - Accession Number: 15985565; Wyler, D. J. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p471; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: PLASMODIUM falciparum; Subject Term: PATIENTS; Subject Term: T cells; Subject Term: PROTOZOAN diseases; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levis, W. R.
AU - Whalen, J. J.
AU - Powell, J. A.
T1 - Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/03//
VL - 23
IS - 3
M3 - Article
SP - 481
EP - 490
PB - Wiley-Blackwell
SN - 00099104
AB - A soluble hapten (dinitrobenzene sulphonic acid (DNBSO3)) and particulate antigens consisting of DNCB, DNFB or DNBSO3 complexed with erythrocytes, all induce a specific blastogenic response and lymphokine production in leucocyte cultures from human subjects topically sensitized to dinitrochlorobenzene (DNCB). While low concentrations (50-100 μg/ml) of DNBSO3 could be left in human leucocyte cultures the entire 4 or 5 days of culture and result in reasonable levels of blastogenesis, it was found that consistently higher degrees of blast transformation resulted when DNCB-sensitive leucocytes were exposed to high concentrations of DNRSO3 (500 μg/ml) for a short period (2 hr). Cell-free supernatants from DNCB-sensitive leucocyte cultures harvested after 48 hr induced blastogenesis and DNA synthesis in secondary target leucocyte cultures from subjects not sensitized to DNCB. Such a blastogenic factor or lymphokine appeared to stimulate even in the absence of any residual antigen, since DNCB complexed to erythrocytes was removed by simple filtration through a 0.45 μm Millepore filter. In contrast to DNCB complexes, the antigenic activity of DNBSO3 completed with erythrocytes was not removed by such filtration. Thus, several DNP-containing haptens (DNCB, DNFB, DNBSO3) induce specific lymphocyte transformation and lymphokine production when exposed in several different manners to leucocytes from humans sensitized to DNCB. The ability to use either a particulate or soluble stimulant in vitro offers a versatile system for studying cell-mediated immunity in humans with a broad range of potential applicability in both investigative and clinical medicine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - ANTIGENS
KW - ERYTHROCYTES
KW - LEUCOCYTES
KW - NUCLEIC acids
KW - IMMUNITY
N1 - Accession Number: 15985570; Levis, W. R. 1 Whalen, J. J. 1 Powell, J. A. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Mar1976, Vol. 23 Issue 3, p481; Subject Term: HAPTENS; Subject Term: ANTIGENS; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: NUCLEIC acids; Subject Term: IMMUNITY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Charles C.
AU - Muenz, Larry R.
T1 - Reduced Means Square Error Estimation in Contingency Tables.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1976/03//
VL - 71
IS - 353
M3 - Article
SP - 176
SN - 01621459
AB - A two-stage estimator is proposed for the cell probabilities in a two-dimensional contingency table. Using a multivariate mean square error criterion, we show that the decision to use either the observed cell probabilities or the estimators assuming row-column independence is approximately dependent upon the noncentrality parameter of the Pearson chi-square statistic chi[sup 2]. We then derive a decision rule that says to use the independence-assumption estimators when chi[sup 2] is less than twice the number of degrees of freedom for testing independence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL models
KW - PROBABILITY theory
KW - MATHEMATICAL statistics
KW - CORRELATION (Statistics)
KW - DISTRIBUTION (Probability theory)
KW - STATISTICAL hypothesis testing
KW - CHI-squared test
N1 - Accession Number: 4609610; Brown, Charles C. 1; Muenz, Larry R. 2; Affiliations: 1: Mathematical statistician, Biometry Branch, National Cancer Institute, Bethesda, Md. 20014.; 2: Mathematical statistician, International Agency for Research on Cancer, 69008-Lyon, France.; Issue Info: Mar1976, Vol. 71 Issue 353, p176; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: PROBABILITY theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: CHI-squared test; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Lavine, Robert
AU - Buchsbaum, Monte S.
AU - Poncy, Mark
T1 - Auditory Analgesia: Somatosensory Evoked Response and Subjective Pain Rating.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1976/03//
VL - 13
IS - 2
M3 - Article
SP - 140
EP - 148
SN - 00485772
AB - Subjective rating responses and averaged evoked responses (AERs) to shock stimuli of varying intensity were recorded in 20 subjects to examine the possible analgesic effects of sound stimulation (music) and suggested analgesia. Subjects (10 men, 10 women, ages 19-31) were divided Into two groups of 10, each receiving the sound-suggestion condition and the no-sound, no-suggestion condition in different order. Sound and suggestion produced the following significant (p <.05) effects: 1) increased electrical stimulus levels required to elicit discomfort ratings; 2) decreased slope of somatosensory AER amplitudes plotted against stimulus intensity; and 3) decreased mean AER amplitudes. These AER effects were greatest In time bands centered mn the P100 component. Prior exposure to the electrical stimuli also reduced AER slopes and mean amplitudes, but mostly in time bands centered on the P200 component. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVOKED potentials (Electrophysiology)
KW - ANALGESICS
KW - ANTI-inflammatory agents
KW - AUDITORY evoked response
KW - AUDITORY perception
KW - SOMATOSENSORY evoked potentials
KW - auditory analgesia
KW - augmentingreducing
KW - average evoked response
KW - eeg
KW - gate theory
KW - pain
KW - somatosensory evoked response
KW - suggestion
N1 - Accession Number: 11685844; Lavine, Robert 1 Buchsbaum, Monte S. 2 Poncy, Mark 1; Affiliation: 1: Department of Physiology, George Washington University Medical Center, Washington, D.C. 2: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.; Source Info: Mar1976, Vol. 13 Issue 2, p140; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: ANALGESICS; Subject Term: ANTI-inflammatory agents; Subject Term: AUDITORY evoked response; Subject Term: AUDITORY perception; Subject Term: SOMATOSENSORY evoked potentials; Author-Supplied Keyword: auditory analgesia; Author-Supplied Keyword: augmentingreducing; Author-Supplied Keyword: average evoked response; Author-Supplied Keyword: eeg; Author-Supplied Keyword: gate theory; Author-Supplied Keyword: pain; Author-Supplied Keyword: somatosensory evoked response; Author-Supplied Keyword: suggestion; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-8986.ep11685844
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-14623-001
AN - 2007-14623-001
AU - Waskow, Irene Elkin
T1 - Research on psychotherapy with women: A workshop introduction.
JF - Psychotherapy: Theory, Research & Practice
JO - Psychotherapy: Theory, Research & Practice
JA - Psychotherapy (Chic)
Y1 - 1976///Spr 1976
VL - 13
IS - 1
SP - 64
EP - 65
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
AD - Waskow, Irene Elkin, National Institute of Mental Health, Rockville, MD, US, 20852
N1 - Accession Number: 2007-14623-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation. Release Date: 20071008. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Psychotherapy; Scientific Communication. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 2. Issue Publication Date: Spr 1976. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1976.
AB - Introduces a series of articles that came from a workshop on Research on Psychotherapy with Women: Traditional and Alternative Models, which was held at the June 1974 meetings of the Society for Psychotherapy Research. Those of us who were involved in the workshop were very excited by it, felt that many stimulating ideas were raised, and that the papers and discussion gave rise to a number of interesting questions for research as well as for the field of psychotherapy, more generally. We wanted to share the material--and hopefully some of the excitement--of the workshop with others interested in this area. We, therefore, prepared this collection of articles, which consists of revised and edited versions of the papers presented at the workshop and a brief summary of the discussion following the papers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Research on Psychotherapy with Women workshop
KW - 1976
KW - Human Females
KW - Psychotherapy
KW - Scientific Communication
KW - 1976
DO - 10.1037/h0086488
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-14624-001
AN - 2007-14624-001
AU - Waskow, Irene Elkin
T1 - Summary of discussion following workshop.
JF - Psychotherapy: Theory, Research & Practice
JO - Psychotherapy: Theory, Research & Practice
JA - Psychotherapy (Chic)
Y1 - 1976///Spr 1976
VL - 13
IS - 1
SP - 96
EP - 98
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
AD - Waskow, Irene Elkin, National Institute of Mental Health, Rockville, MD, US, 20852
N1 - Accession Number: 2007-14624-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation. Release Date: 20071008. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Psychotherapy; Scientific Communication. Minor Descriptor: Sexism; Social Issues; Therapist Characteristics; Treatment Outcomes; Values. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Female (40). Page Count: 3. Issue Publication Date: Spr 1976. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1976.
AB - Summarizes the highlighted articles from the workshop on Research on Psychotherapy with Women: Traditional and Alternative Models, held at the June 1974 Society for Psychotherapy Research. There were several main themes in the discussion that followed the five presentations: existence of sexism in traditional psychotherapies; role of therapist sex vs. therapist attitudes and ideology; biases in outcome criteria used in research; comparisons of different treatment models for women; values and social issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Research on Psychotherapy with Women workshop
KW - sexism
KW - therapists
KW - treatment outcome criteria
KW - treatment models
KW - values
KW - social issues
KW - 1976
KW - Human Females
KW - Psychotherapy
KW - Scientific Communication
KW - Sexism
KW - Social Issues
KW - Therapist Characteristics
KW - Treatment Outcomes
KW - Values
KW - 1976
DO - 10.1037/h0086494
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Magrath, I. T.;
AU - Ziegler, J. L.;
T1 - Failure of BCG immunostimulation to affect the clinical course of Burkitt's lymphoma
CT - Failure of BCG immunostimulation to affect the clinical course of Burkitt's lymphoma
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1976/03/13/
VL - 1
IS - Mar 13
SP - 615
EP - 618
SN - 09598146
AD - Lymphoma Treatment Centre, Makerere Univ. Medical School, Uganda Cancer Institute, Kampala, Uganda
AD - Reprints: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland
N1 - Accession Number: 13-4267; Language: English; References: 31; Journal Coden: BMJOAE; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A controlled randomized trial was carried out to evaluate the efficacy of BCG immunotherapy in preventing relapse in patients with Burkitt's lymphoma in whom remission had been induced with cyclophosphamide. Twenty-one patients were treated with BCG, and 19 were controls. Pasteur Institute lyophilized BCG was used; 0.5 ml of a freshly reconstituted suspension containing 150 mg of BCG dry weight and about 13 \X/ 10\SU/8\BS/ viable organisms was given at each application. Scarification was performed on each limb in turn every 4 days for 7 doses and then weekly for 6 doses, giving a total of 10 weeks' immunotherapy. Eleven patients in each group relapsed during a follow-up period long enough to make it unlikely that further relapses would occur. There were no significant differences in the length of remission or the site of relapse that could be attributed to treatment. Eleven patients died: of these none of the 6 patients in the BCG group but all of the 5 in the control group had stage D lymphomas. BCG treatment increased the rate of recovery from tumor induced immunosuppression, but within the BCG group immunocompetence improved most rapidly in the patients who relapsed\M/a finding that appears to contradict the tenet rationalizing the use of immunological adjuvants as treatment.
KW - BCG vaccines--Burkitt's lymphoma-;
KW - Immunotherapy--BCG vaccines--Burkitt's lymphoma, lack, effects, on relapse, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - AOKI, TADAO
AU - LIU, MARGARET
AU - WALLING, MARY JANE
AU - BUSHAR, GRACE S.
AU - BRANDCHAFT, PHYLLIS B.
AU - KAWAKAMI, THOMAS G.
T1 - Specificity of Naturally Occurring Antibody in Normal Gibbon Serum.
JO - Science
JF - Science
Y1 - 1976/03/19/
VL - 191
IS - 4232
M3 - Article
SP - 1180
EP - 1183
SN - 00368075
AB - Gibbon natural antibody examined by immunoelectron microscopy reacted with the entire envelope of type C virus and with areas on the cell surface equivalent to or smaller than the diameter of a virion in gibbon and human culture cells infected with or releasing type C viruses. The antibody activity was absorbed completely by two cell cultures infected with gibbon ape leukemia virus and by the virus itself, and partially by normal gibbon spleen cells and dog thymus-derived cells infected with baboon endogenous type C virus, and fresh white blood cells obtained from a patient with chronic myelogenous leukemia in acute blastic crisis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219858; AOKI, TADAO 1; LIU, MARGARET 1; WALLING, MARY JANE 1; BUSHAR, GRACE S. 1; BRANDCHAFT, PHYLLIS B. 1; KAWAKAMI, THOMAS G. 2; Affiliations: 1: Immunology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; 2: Comparative Oncology Laboratory, University of California, Davis 95616; Issue Info: 3/19/1976, Vol. 191 Issue 4232, p1180; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FRANKEL, ARTHUR E.
AU - HAAPALA, DANIEL K.
AU - NEUBAUER, RICHARD L.
AU - FISCHINGER, PETER J.
T1 - Elimination of the Sarcoma Genome from Murine Sarcoma Virus Transformed Cat Cells.
JO - Science
JF - Science
Y1 - 1976/03/26/
VL - 191
IS - 4233
M3 - Article
SP - 1264
EP - 1266
SN - 00368075
AB - Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219888; FRANKEL, ARTHUR E. 1; HAAPALA, DANIEL K. 1; NEUBAUER, RICHARD L. 1; FISCHINGER, PETER J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/26/1976, Vol. 191 Issue 4233, p1264; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SITARAM, N.
AU - WYATT, RICHARD JED
AU - DAWSON, SUSAN
AU - GILLIN, J. CHRISTIAN
T1 - REM Sleep Induction by Physostigmine Infusion During Sleep.
JO - Science
JF - Science
Y1 - 1976/03/26/
VL - 191
IS - 4233
M3 - Article
SP - 1281
EP - 1283
SN - 00368075
AB - Physostigmine (an anticholinesterase agent that increases acetylcholine at the synapse), in a dose of 0.5 milligram, was given intravenously to seven normal human volunteers. When injected during rapid eye movement (REM) sleep, physostigmine woke the subjects, and when injected during non-REM sleep, it induced REM sleep. This result suggests that cholinergic mechanisms play a role in the induction of REM sleep and in modulating cortical arousal mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219898; SITARAM, N. 1; WYATT, RICHARD JED 2; DAWSON, SUSAN 2; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, and Adult Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/26/1976, Vol. 191 Issue 4233, p1281; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Canellos, G. P.;
AU - DeVita, V. T.;
AU - Gold, G. L.;
AU - Chabner, B. A.;
AU - Young, R. C.;
AU - \ET/;
T1 - Combined chemotherapy for advanced breast cancer: response and effect on survival
CT - Combined chemotherapy for advanced breast cancer: response and effect on survival
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/04/01/
VL - 84
IS - Apr
SP - 389
EP - 392
SN - 00034819
AD - National Cancer Institute, Bldg. 10, Room 12N236, Bethesda, Maryland 20014
N1 - Accession Number: 14-0111; Language: English; Chemical Name: Methotrexate--59-05-2 Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 20; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program, which included methotrexate, 60 mg/sq m, and fluorouracil, 700 mg/sq m, IV on days 1 and 8, in addition to cyclophosphamide, 100 mg/sq m, and prednisone, 40 mg/sq m, orally each day from the first to the fourteenth day of a 28 day cycle. Complete response (8 patients) or partial response (19 patients) was seen in 68% of cases. Lung, soft tissue, and nodal metastases were the most responsive sites. The median duration of antitumor response was 8 months, with a median survival of 18 months for the responding group. The nonresponders had a median survival of 4 months. The toxicity was primarily hematologic and was especially severe in patients with functional liver impairment due to metastatic disease.
KW - Methotrexate--cyclophosphamide, fluorouracil and prednisone-;
KW - Cyclophosphamide--fluorouracil, methotrexate and prednisone-;
KW - Fluorouracil--cyclophosphamide, methotrexate and prednisone-;
KW - Prednisone--cyclophosphamide, fluorouracil and methotrexate-;
KW - Antineoplastic agents--methotrexate--combined therapy, metastatic breast cancer, in women;
KW - Antineoplastic agents--fluorouracil--combined therapy, metastatic breast cancer, in women;
KW - Antineoplastic agents--cyclophosphamide--combined therapy, metastatic breast cancer, in women;
KW - Antineoplastic agents--prednisone--combined therapy, metastatic breast cancer, in women;
KW - Combined therapy--antineoplastic agents--cancer, metastatic breast, in women;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Fauci, A. S.
T1 - Mechanisms of corticosteroid action on lymphocyte subpopulations II. DIFFERENTIAL EFFECTS OF IN VIVO HYDROCORTISONE, PREDNISONE AND DEXAMETHASONE ON IN VITRO EXPRESSION OF LYMPHOCYTE FUNCTION.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/04//
VL - 24
IS - 1
M3 - Article
SP - 54
EP - 62
PB - Wiley-Blackwell
SN - 00099104
AB - The present study was undertaken to determine what, if any, differential effects various commonly used corticosteroid preparations had on the numbers and specific functions of lymphocyte subpopulations when these agents were administered in equivalent pharmacological dosages. Normal volunteers received a single dose of either 320 trig of hydrocortisone intravenously, 80 mg of prednisone orally, or 12 mg of dexamethasone orally. There was a marked lyrnphocytopenia and monocytopenia maximal 4 6 hr following administration of all three corticosteroid preparations with almost identical kinetics and degree of fail in total cell numbers as well as proportions of thymus-derived and bone marrow-derived lymphocytes. Hydrocortisone and prednisone caused only a slight suppression of phytohaemagglutinin (PHA) induced lymphocyte blastogenesis which could be reversed at supra-optimal concentrations of PHA. On the contrary. dexamethasone administration caused a marked suppression of PHA responses which was not reversed by supra-optimal PHA stimulation. In addition, hydrocortisone and prednisone administration did not suppress non-specific PHA-induced cellular cytotoxicity, while dexamethasone caused a marked suppression (P<0.001) of cytotoxicity. These studies show that although equivalent anti-inflammatory doses of these three corticosteroid preparations cause almost identical suppression of the numbers of circulating lymphocyte populations, they have a differential effect on certain in vitro functional correlates of cell-mediated immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - LEUCOCYTES
KW - CELLULAR immunity
KW - ENDOCRINE glands
KW - BONE marrow
KW - HYDROCORTISONE
N1 - Accession Number: 17115771; Fauci, A. S. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Apr1976, Vol. 24 Issue 1, p54; Subject Term: LYMPHOID tissue; Subject Term: LEUCOCYTES; Subject Term: CELLULAR immunity; Subject Term: ENDOCRINE glands; Subject Term: BONE marrow; Subject Term: HYDROCORTISONE; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hamel, Ernest
T1 - Interactions of Guanosine Triphosphate Analogues with Elongation Factor G of Escherichia coli.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/04//Apr76 Part 1
VL - 63
IS - 2
M3 - Article
SP - 431
EP - 440
PB - Wiley-Blackwell
SN - 00142956
AB - Previous studies from this laboratory have shown that the GTP analogue guanosine Y-diphosphate 5′-triphosphate (pppGpp) was almost without activity in the translocation reaction catalyzed by elongation factor G (EF-G), while it was fully active with elongation factor T (EF-T) and initiation factor 2 (IF-2). To assess the importance of the 3′-ribose hydroxyl itself in the translocation reaction, we examined polyphenylalanine synthesis and EF-G-dependent formation of N-acetylphenylalanylphenylalanylpuromycin (Ac-Phe2-puromycin) supported by 3′-deoxyguanosine 5′-triphosphate (YdGTP) and 3′-deoxy-3′-aminoguanosine 5′-triphosphate (3′dNH2GTP). Like pppGpp, these nucleotides were similar to GTP in EF-T and IF-2-dependent reactions. We also examined the ability of the dialcohol derived from GTP by periodate oxidation and borohydride reduction (rroGTP) and of ITP to support translocation. These compounds had shown significant, although reduced, activity with EF-T and IF-2. A spectrum of activity was found with these compounds in both poly(Phe) synthesis and Ac-Phe2-puromycin formation. All had significantly reduced activity relative to GTP, but all were significantly more active than pppGpp. A surprising finding was that the activities of all analogues relative to GTP were dependent on the reaction temperature in both poly(Phe) synthesis and Ac-Phe2-puromycin formation; these relative activities were significantly lower at 8°C than 37°C. Furthermore, the extent of poly(Phe) synthesis with the analogues relative to GTP could be significantly affected by the amounts of EF-G and EF-T in the reaction mixture. Differences were minimized in the presence of rate-limiting EF-T and saturating EF-G and maximized in the presence of rate-limiting EF-G and saturating EF-T. This effect of reducing the level of EF-G in the reaction mixture thus mimicked the effect of lowering the incubation temperature, and a similar observation was made for Ac-Phe2-puromycin formation. GTP-supported formation of Ac-Phe2-puromycin at 8°C could be inhibited by 3′dNH2GTP, YdGTP, pppGpp, and ITP: these compounds were better inhibitors than they were substrates. Inhibition by other nucleotides was also noted. The GTP analogues were compared to GTP as substrates in EF-G-dependent reactions uncoupled from protein synthesis. Fusidic-acid-dependent binding of nucleotides to ribosomes and ribosome-dependent catalytic nucleotide hydrolysis were both examined, and the activity of the nucleotides as substrates in these reactions showed little correlation with their ability to support translocation. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUANOSINE triphosphatase
KW - ESCHERICHIA coli
KW - BIOCHEMISTRY
KW - PUROMYCIN
KW - RAS proteins
KW - PHOSPHATASES
N1 - Accession Number: 13490344; Hamel, Ernest 1; Affiliation: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Apr76 Part 1, Vol. 63 Issue 2, p431; Subject Term: GUANOSINE triphosphatase; Subject Term: ESCHERICHIA coli; Subject Term: BIOCHEMISTRY; Subject Term: PUROMYCIN; Subject Term: RAS proteins; Subject Term: PHOSPHATASES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Patricia J.
AU - Lint, T. F.
AU - Siegel, Joan
AU - Kies, Marian W.
AU - Gewurz, H.
T1 - Potentiation of C¯56-initiated lysis by leucocyte cationic proteins, myelin basic proteins and lysine-rich histones.
JO - Immunology
JF - Immunology
Y1 - 1976/04//
VL - 30
IS - 4
M3 - Article
SP - 467
EP - 473
PB - Wiley-Blackwell
SN - 00192805
AB - Synthetic polycations such as poly-Llysine (PLL) have recently been shown to enhance C&56macr;-initiated lysis by neutralization of serumderived inhibitors of the C&567macr; complex, collectively designated C&567macr;-INH. In the present report we have examined the effect of several naturally occurring polycations on C&56macr;-initiated lysis, Lysosomal granule extracts from rabbit peritoneal exudate cells were found to potentiate C&56macr;-initiated lysis via counteraction of C&567macr;-INH in the fluid phase; this was dependent upon the amount of C&567macr;INH present and independent of cell concentration. The basic proteins of guinea-pig, bovine, and monkey myelin as well as lysine-rich histones also potentiated EC&567macr; formation, but this effect seemed to occur predominantly at the ceil surface. The presence of biologically derived cationic proteins at sites of complement activation during inflammation thus might lead to enhanced tissue damage by favouring the formation of cell-C&567macr; intermediates by either or both of these mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYSINE
KW - BASIC proteins
KW - AMINO acids
KW - IMMUNITY
KW - MYELIN basic protein
KW - HISTONES
N1 - Accession Number: 13358668; Baker, Patricia J. 1 Lint, T. F. 1 Siegel, Joan 1 Kies, Marian W. 1 Gewurz, H. 1; Affiliation: 1: Departments of Immunology, Rush Medical College and Microbiology, University of Illinois at the Medical Center, Chicago, Illinois, and Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland, U.S.A.; Source Info: Apr76, Vol. 30 Issue 4, p467; Subject Term: LYSINE; Subject Term: BASIC proteins; Subject Term: AMINO acids; Subject Term: IMMUNITY; Subject Term: MYELIN basic protein; Subject Term: HISTONES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waldrop, Mary F.
AU - Bell, Richard Q.
AU - Goering, Jacob D.
T1 - MINOR PHYSICAL ANOMALIES AND INHIBITED BEHAVIOR IN ELEMENTARY SCHOOL GIRLS.
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1976/04//
VL - 17
IS - 2
M3 - Article
SP - 113
EP - 122
SN - 00219630
AB - A set of 18 minor physical anomalies has been identified with Down's Syndrome, commonly referred to as mongolism. Most of the general population, however, possess two or more of these anomalies. This dimension represents fast moving, impulsive, clumsy behavior at one extreme and attentive, controlled, well-coordinated behavior at the other extreme. In other words, there is evidence of a genetic or congenital contributor to several aspects of child behavior that are important in basic psychological research on attention, pace, and impulse control, not just a contributor to relatively rare clinical conditions.
KW - SCHOOL children
KW - DOWN syndrome
KW - CHILD psychology
KW - BEHAVIOR
KW - CHILD psychopathology
KW - IMPULSE (Psychology)
N1 - Accession Number: 11903751; Waldrop, Mary F. 1 Bell, Richard Q. 1 Goering, Jacob D. 2; Affiliation: 1: National Institute of Mental Health. 2: University of Maryland.; Source Info: Apr1976, Vol. 17 Issue 2, p113; Subject Term: SCHOOL children; Subject Term: DOWN syndrome; Subject Term: CHILD psychology; Subject Term: BEHAVIOR; Subject Term: CHILD psychopathology; Subject Term: IMPULSE (Psychology); Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1469-7610.ep11903751
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kent, Robert L.
AU - Lutzner, Marvin A.
AU - Smith, Kitty P.
T1 - SKIN EXFOLIATION AND PURULENT CONJUNCTIVITIS IN A NEW MUTANT-THE EXFOLIATIVE MOUSE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/04//
VL - 66
IS - 4
M3 - Article
SP - 248
EP - 251
SN - 0022202X
AB - A spontaneous autosomal recessive mutation has been named the exfoliative mouse (genotype ex/ex). Exfoliative mice suffer a transient purulent conjunctivitis in their 3rd week and an exfoliative skin disease in their 4th week. Gram-negative bacilli are present in blood and cerebrospinal fluid during the conjunctivitis stage, and in skin during the exfoliative period. The mutant can be differentiated from the ichthyotic mouse mutant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICAL peel
KW - CONJUNCTIVITIS
KW - MUTATION (Biology)
KW - ANIMAL mutation
KW - MICE
KW - SKIN diseases
N1 - Accession Number: 12482173; Kent, Robert L. 1 Lutzner, Marvin A. 1 Smith, Kitty P. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U. S. A. 2: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Apr76, Vol. 66 Issue 4, p248; Subject Term: CHEMICAL peel; Subject Term: CONJUNCTIVITIS; Subject Term: MUTATION (Biology); Subject Term: ANIMAL mutation; Subject Term: MICE; Subject Term: SKIN diseases; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12482173
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Otani, T. T.;
AU - Briley, M. R.;
T1 - \b/-Hydroxynorleucine: separation of its isomers and biological studies
CT - \b/-Hydroxynorleucine: separation of its isomers and biological studies
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/04/01/
VL - 65
IS - Apr
SP - 534
EP - 537
SN - 00223549
AD - Nucleic Acids Sec., Laboratory of Physiology, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-5576; Language: English; References: 12; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2 - Separation of the 4 isomers of \b/-hydroxynorleucine by column chromatography, synthesis of the corresponding N-chloroacetyl derivatives and screening for antitumor activity in vitro, are discussed.
KW - \b/-Hydroxynorleucine--isomers-;
KW - Isomers--\b/-hydroxynorleucine--separation, column chromatography, synthesis and screening of N-chloroacetyl derivatives;
KW - Chromatography, column--\b/-hydroxynorleucine--isomers, separation, synthesis and screening of N-chloroacetyl derivatives;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-42046-018
AN - 2013-42046-018
AU - Shore, Milton F.
T1 - Review of Not for the poor alone: European social services.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/04//
VL - 46
IS - 2
SP - 369
EP - 370
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42046-018. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Services; Language; Social Responsibility; Social Services; Technology. Minor Descriptor: Social Psychology. Classification: Community & Social Services (3373). Population: Human (10). Location: Europe. Reviewed Item: Kahn, Alfred J.; Kamerman, Sheila B. Not for the poor alone: European social services=185 pp. $10.00. Temple University Press, Philadelphia; 1975. Page Count: 2. Issue Publication Date: Apr, 1976.
AB - Reviews the book, Not for the Poor Alone: European Social Services by Alfred J. Kahn and Sheila B. Kamerman (1975). Kahn and Kamerman try to describe social welfare services difference in their book. Authors' detail in non-technical language their visits to specific human service programs for all ages in four countries-France, Sweden, Denmark, and the United Kingdom. However, what comes across in this book, and in visits the reviewer has made to many European countries, is the pride in social responsibility and services to others that permeates a large part of these societies. Excitement and optimism pervade the social services of the countries described in the book. This book reads at times like a trip report (with many repetitions), and does not deal with how some of the programs might be adapted to the United States with its greater heterogeneity, its unique history, and its special problems. They also demonstrate how irrelevant are suggestions of loss of individual freedom if similar programs were to be adopted in the United States. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - poor alone
KW - European social services
KW - non technical language
KW - human service programs
KW - social responsibility
KW - 1976
KW - Human Services
KW - Language
KW - Social Responsibility
KW - Social Services
KW - Technology
KW - Social Psychology
KW - 1976
U2 - Kahn, Alfred J.; Kamerman, Sheila B. (1975); Not for the poor alone: European social services; 185 pp. $10.00. Temple University Press, Philadelphia
DO - 10.1037/h0098749
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GRALNICK, HARVEY R.
AU - COLLER, BARRY S.
AU - SULTAN, YVETTE
T1 - Carbohydrate Deficiency of the Factor VIII/von Willebrand Factor Protein in von Willebrand's Disease Variants.
JO - Science
JF - Science
Y1 - 1976/04/02/
VL - 192
IS - 4234
M3 - Article
SP - 56
EP - 59
SN - 00368075
AB - Study of the normal human factor VIII/von Willebrand factor reveals a macromolecular glycoprotein composed of apparently identical subunits. This purified glycoprotein has procoagulant, antigen, and von Willebrand factor activities. In three patients with a variant of the von Willebrand's disease syndrome, their factor VIII/von Willebrand factor protein was present in normal amounts and had normal procoagulant and antigen activities; however, this protein was deficient in both carbohydrate and von Willebrand factor activity. The carbohydrate portion of the factor VIII/von Willebrand factor glycoprotein is of major importance in its interactions with platelets or the blood vessel wall, or both. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219933; GRALNICK, HARVEY R. 1; COLLER, BARRY S. 1; SULTAN, YVETTE 2; Affiliations: 1: Hematology Service, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20014; 2: Hopital Saint-Louis, Paris, France; Issue Info: 4/ 2/1976, Vol. 192 Issue 4234, p56; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - DuPont, R. L.;
AU - Dormer, R. A.;
AU - Nightingale, S. L.;
T1 - Treatment of narcotics addiction with narcotic drugs
CT - Treatment of narcotics addiction with narcotic drugs
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/04/12/
VL - 235
IS - Apr 12
SP - 1565
EP - 1566
AD - National Institute on Drug Abuse, 11400 Rockville Pike, Rockville, Maryland 20852
N1 - Accession Number: 13-4728; Language: English; Chemical Name: Methadone--76-99-3; References: 4; Journal Coden: JAMAAP; Section Heading: Legislation, Laws and Regulations; Abstract Author: Joan Lentine
N2 - Present U.S. regulations concerning the use of methadone in the treatment of narcotics addiction are discussed.
KW - Methadone--regulations-;
KW - Regulations--methadone--dependence, narcotics, therapy, discussion;
KW - Dependence--narcotics--therapy, methadone, regulations, discussion;
KW - Narcotics--dependence--therapy, methadone, regulations, discussion;
KW - Toxicity--narcotics--dependence, methadone therapy, regulations, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ANFINSEN, CHRISTIAN B.
T1 - Solar Energy.
JO - Science
JF - Science
Y1 - 1976/04/16/
VL - 192
IS - 4236
M3 - Article
SP - 198
EP - 198
SN - 00368075
N1 - Accession Number: 85363180; ANFINSEN, CHRISTIAN B. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/16/1976, Vol. 192 Issue 4236, p198; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Caffey, E. M.;
AU - Prein, R. F.;
T1 - Relationship between dosage and response to lithium prophylaxis in recurrent depression
CT - Relationship between dosage and response to lithium prophylaxis in recurrent depression
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1976/05/01/
VL - 133
IS - May
SP - 567
EP - 570
SN - 0002953X
AD - Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 13-5145; Language: English; Chemical Name: Lithium carbonate--554-13-2; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents lithium carbonate; References: 14; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: C. Robert Sturwold
N2 - The results of a multihospital collaborative study on the effectiveness of lithium carbonate (I) prophylaxis in recurrent depression were analyzed. Forty-five patients were admitted to the study following hospitalization for acute depression. All had experienced at least one affective mood episode requiring hospitalization during the preceding 2 yr and 2 episodes requiring hospitalization during the preceding 5 yr. Diagnoses were manic-depressive psychosis, depressed type, and recurrent endogenous depression. I was administered at dosages to produce serum lithium levels in the range of 0.5 to 1.2 meq/L. Patients were evaluated every 4 weeks following discharge for a 2 yr period. Of the 32 patients completing the study, recurrent episodes occurred in 53% of those receiving daily doses of one g or less of I compared with 20% for those receiving doses exceeding one g daily. Fifty-five percent of the patients whose I levels were 0.70 meq/L or less experienced recurrent episodes compared with 14% of patients with higher levels. It is suggested that I may be effective prophylactically in the treatment of recurrent depression but emphasize the need for well controlled studies to establish dosage guidelines.
KW - Lithium carbonate--depression-;
KW - Dosage--lithium carbonate--depression, recurrent, prophylaxis, and blood levels, in patients;
KW - Blood levels--lithium carbonate--depression, recurrent, prophylaxis, and dosage, in patients;
KW - Metabolism--lithium carbonate--blood levels, recurrent depression, prophylaxis, and dosage, in patients;
KW - Psychotherapeutic agents--lithium carbonate--depression, recurrent, prophylaxis, blood levels and dosage, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Fears, Thomas R.
AU - Scotto, Joseph
AU - Schneiderman, Marvin A.
T1 - Skin Cancer, Melanoma, and Sunlight.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/05//
VL - 66
IS - 5
M3 - Article
SP - 461
PB - American Public Health Association
SN - 00900036
AB - Recent theoretical studies suggest that the earth's ozone layer which filters ultraviolet radiation may be depleted by a fleet of supersonic transports or by continued use of chlorofluoromethanes. It is now generally accepted that short wavelength ultraviolet radiation leads to the development of skin cancer. In this report we demonstrate an approach to estimating the increase in skin cancer incidence associated with increases in ultraviolet radiation. The purpose is to demonstrate the logic used and the assumptions that must be made when such estimates are made or cited. We emphasize that such estimates should be considered crude until the many assumptions can be investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Cancer
KW - MELANOMA
KW - ULTRAVIOLET radiation
KW - NEUROENDOCRINE tumors
KW - SKIN care
KW - OZONE layer
KW - CHLOROFLUOROMETHANE
KW - STRATOSPHERE
KW - PUBLIC health
N1 - Accession Number: 5666391; Fears, Thomas R. 1 Scotto, Joseph 2 Schneiderman, Marvin A. 3; Affiliation: 1: Office of Field Studies & Statistics National Cancer Institute, 7910 Woodmont Avenue, Bethesda, MD 20014 2: Demography Section, Biometry Branch, National Cancer Institute 3: Associate Director, Field Studies and Statistics, National Cancer Institute; Source Info: May76, Vol. 66 Issue 5, p461; Subject Term: SKIN -- Cancer; Subject Term: MELANOMA; Subject Term: ULTRAVIOLET radiation; Subject Term: NEUROENDOCRINE tumors; Subject Term: SKIN care; Subject Term: OZONE layer; Subject Term: CHLOROFLUOROMETHANE; Subject Term: STRATOSPHERE; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schooler, Carrel
T1 - Serfdom's Legacy: An Ethnic Continuum.
JO - American Journal of Sociology
JF - American Journal of Sociology
Y1 - 1976/05//
VL - 81
IS - 6
M3 - Article
SP - 1265
EP - 1286
SN - 00029602
AB - The effects of ethnicity appear to occur along a historically determined continuum which reflects the social, legal, economic, and occupational conditions of the European countries from which American ethnic groups emigrated. Ethnic groups with a recent history of serfdom show the intellectual inflexibility, authoritarianism, and pragmatic legalistic morality previously found characteristic of American men working under occupational conditions limiting the individual's opportunity for self-direction. Although it is impossible to confirm each link in the causal chain, a model emphasizing the effects on ethnic groups' culture of historical conditions restricting the individual's autonomy seems a probable and parsimonious explanation of contemporary ethnic differences. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Sociology is the property of University of Chicago Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHNICITY
KW - GROUP identity
KW - WORK
KW - LAW
KW - RACE
KW - RACE relations
KW - EUROPE -- Economic conditions
KW - EUROPE -- Social conditions
KW - SERFS
KW - ETHNIC groups
KW - EUROPE
KW - UNITED States
N1 - Accession Number: 15579820; Schooler, Carrel 1; Affiliations: 1 : National Institute of Mental Health; Source Info: May76, Vol. 81 Issue 6, p1265; Historical Period: 1800 to 1999; Subject Term: ETHNICITY; Subject Term: GROUP identity; Subject Term: WORK; Subject Term: LAW; Subject Term: RACE; Subject Term: RACE relations; Subject Term: EUROPE -- Economic conditions; Subject Term: EUROPE -- Social conditions; Subject Term: SERFS; Subject Term: ETHNIC groups; Subject: EUROPE; Subject: UNITED States; Number of Pages: 22p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Furano, Anthony V.
T1 - The Subcellular Distribution and State of the Elongation Factor Tu in Extracts of Escherichia coliB.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/05//May76 Part 1
VL - 64
IS - 2
M3 - Article
SP - 597
EP - 606
PB - Wiley-Blackwell
SN - 00142956
AB - The concentration of elongation factor Tu (EF-Tu) is about 8 times that of ribosomes in extracts of Escherichia coli B grown in glucose-minimal medium. 90% of the EF-Tu is found in the ribosome-free fraction of the cell and 75% of this is free of other macromolecules as judged by chromatography on Sephadex G-100 ; about 10% is bound to the elongation factor EF-Ts and the remaining 10–l 5% is eluted from Sephadex G-100 earlier than expected for its molecular weight. Tryptic peptide maps of the three forms of EF-Tu are essentially indistinguishable. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - ENTEROBACTERIACEAE
KW - CHROMATOGRAPHIC analysis
KW - MOLECULAR weights
KW - DEXTRAN
KW - ION exchange (Chemistry)
KW - COLLOIDS
N1 - Accession Number: 13490193; Furano, Anthony V. 1; Affiliation: 1: Laboratory of Bichemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: May76 Part 1, Vol. 64 Issue 2, p597; Subject Term: ESCHERICHIA coli; Subject Term: ENTEROBACTERIACEAE; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MOLECULAR weights; Subject Term: DEXTRAN; Subject Term: ION exchange (Chemistry); Subject Term: COLLOIDS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Grove, W. R.;
AU - Fortner, C. L.;
T1 - Carcinoma of the breast
CT - Carcinoma of the breast
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1976/05/01/
VL - NS 16
IS - May
SP - 254
EP - 262
AD - Clinical Research Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, Univ. of Maryland Hospital, Baltimore, Maryland
N1 - Accession Number: 14-3562; Language: English; References: 22; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: James A. Starner
N2 - Current concepts in the therapy of breast cancer are discussed against a background of the pathology, etiology and diagnosis of the disease.
KW - Antineoplastic agents--cancer--breast, therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Hodes, Louis
T1 - Selection of descriptors according to discrimination and redundancy. application to chemical structure searching
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1976/05//
VL - 16
IS - 2
M3 - Article
SP - 88
EP - 93
SN - 00952338
AB - Descriptor, for our purposes, will be fragment scrrens in a chemical search system. Given a file of compounds, the discrimination of a set of descriptors can be defined in terms of their incidence and mutual incidence in the file. A theory is developed which provides both a heuristic for selecting descriptors and a method for evaluating their marginal discrimination. These ideas have been used to generate an efficient scrren code for a large file of chemical structures.
N1 - Accession Number: ISTA1102323; Hodes, Louis 1; Affiliations: 1 : National Cancer Institute, National Institutes Of Health, Department Of Health, Education, And Welfare, Bethesda, Maryland; Source Info: May 1976, Vol. 16 Issue 2, p88; Note: Update Code: 1100; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Elgjo, Kjell
AU - Hennings, Henry
AU - Michael, Delores
AU - Yuspa, Stuart H.
T1 - NATURAL SYNCHRONY OF NEWBORN MOUSE EPIDERMAL CELLS IN VITRO.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/05//
VL - 66
IS - 5
M3 - Article
SP - 292
EP - 296
SN - 0022202X
AB - Epidermal cells were separated from newborn mouse skin and grown on glass chamber slides or in plastic Petri dishes. Cell proliferation was examined at short intervals during the first 3 to 4 days in culture. DNA synthesis was estimated by the incorporation of [³H]thymidine into epidermal DNA, or by the labeling index. The mitotic rate was estimated by blocking mitotic cells with vinblastine. Reasonable agreement was found with the different methods. The cells grew synchronously with peaks of DNA synthesis at 21 to 23 hr, 35 to 40 hr, and 60 hr; peak mitotic rates were seen at 44 to 48 hr and 72 to 76 hr. The cells appeared to grow exponentially during the first 3 to 4 days in culture, with one main cohort of cells dividing during the successive proliferative peaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - CELLS
KW - CELL proliferation
KW - THYMIDINE
KW - VINBLASTINE
KW - DNA
KW - MITOSIS
N1 - Accession Number: 12482235; Elgjo, Kjell 1 Hennings, Henry 1 Michael, Delores 1 Yuspa, Stuart H. 1; Affiliation: 1: In Vitro Pathogenesis Section, Experimental Pathology Branch, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May76, Vol. 66 Issue 5, p292; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: CELL proliferation; Subject Term: THYMIDINE; Subject Term: VINBLASTINE; Subject Term: DNA; Subject Term: MITOSIS; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12482235
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Throne, Philip R.
AU - Engel, Bernard T.
AU - Holmblad, John B.
T1 - An Analysis of the Error Inherent in Estimating Heart Rate From Cardiotachometer Records.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1976/05//
VL - 13
IS - 3
M3 - Article
SP - 269
EP - 272
SN - 00485772
AB - This paper discusses the inherent discrepancy between the mean heart rate computed from a series of cardiotachometer data points and the true average heart rate. A mathematical proof that the man cardiotachometer rate always exceeds the true rate when individual beats are sampled in the presence of variability is given. Examples which illustrate the magnitude of the discrepancy also are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART beat
KW - HEMODYNAMICS
KW - NEUROLOGICAL errors
KW - MEDICAL equipment
KW - PSYCHOPHYSIOLOGY
KW - PSYCHOBIOLOGY
KW - DESCRIPTORS: Heart rate. Cardiotachometer
KW - Heart period.
N1 - Accession Number: 11728805; Throne, Philip R. 1 Engel, Bernard T. 1 Holmblad, John B. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging National Institute of Health, PHS US Department of Health Education and Welfare, Bethesda, and the Baltimore City Hospitals.; Source Info: May1976, Vol. 13 Issue 3, p269; Subject Term: HEART beat; Subject Term: HEMODYNAMICS; Subject Term: NEUROLOGICAL errors; Subject Term: MEDICAL equipment; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: PSYCHOBIOLOGY; Author-Supplied Keyword: DESCRIPTORS: Heart rate. Cardiotachometer; Author-Supplied Keyword: Heart period.; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1469-8986.ep11728805
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Alexander, J. C.;
AU - Silverman, N. A.;
AU - Chretien, P. B.;
T1 - Effect of age and cigarette smoking on carcinoembryonic antigen levels
CT - Effect of age and cigarette smoking on carcinoembryonic antigen levels
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/05/03/
VL - 235
IS - May 3
SP - 1975
EP - 1979
AD - Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-5549; Language: English; References: 16; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Serum carcinoembryonic antigen levels were determined by the Hanzen-Z-gel technique in 276 healthy volunteers, of whom 154 were smokers and 122 nonsmokers. The mean level was significantly higher in smokers (2.7 ng/ml) than in nonsmokers (1.9 ng/ml) (P \LT/ .001), and a significantly higher percentage of smokers had elevated levels (P \LT/ .05). In both groups, levels were directly related to age. Seventy-six of the 154 smokers who entered the study ceased smoking. Their levels were determined at one, 3, and 6 months after cessation of smoking. Within 3 months after cessation, elevated levels declined to within the range of nonsmokers and did not appear to be influenced by previous smoking habits. Both age and smoking history must be considered for accurate evaluation of levels. A reappraisal of the diseases associated with elevated levels that considers the influence of age and smoking may invalidate some of the correlations previously reported.
KW - Cigarettes--smoking--effects, on serum carcinoembryonic antigen levels, in humans;
KW - Smoking--cigarettes--effects, on serum carcinoembryonic antigen levels, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Williams, R. R.;
T1 - Breast and thyroid cancer and malignant melanoma promoted by alcohol induced pituitary secretion of prolactin, TSH, and MSH
CT - Breast and thyroid cancer and malignant melanoma promoted by alcohol induced pituitary secretion of prolactin, TSH, and MSH
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/05/08/
VL - 1
IS - May 8
SP - 996
EP - 999
SN - 00237507
AD - National Institutes of Health, N.H.L.I., Landow C-825, Bethesda, Maryland 20014
N1 - Accession Number: 13-4817; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 37; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Toxicity
N2 - In interview data from the U.S.A.'s Third National Cancer Survey, alcohol ingestion was associated with a higher occurrence of cancers of the breast, thyroid, and malignant melanoma. Data from other studies support the first 2 associations. A unifying hypothesis to explain these seemingly diverse associations suggests that alcohol stimulates anterior pituitary secretion of prolactin, thyroid stimulating hormone (TSH), and melanocyte stimulating hormone (MSH). Under the stimulation of these hormones, the 3 target tissues exhibit increased mitotic activity and hence an increased susceptibility to the development of a malignancy. A wide variety of findings from other studies indicate plausibility for this hypothesis. In addition to alcohol, several common drugs acting in a similar manner could be cancer promoters, including: reserpine, methyldopa, phenothiazines, dextroamphetamine, tricyclic antidepressants and antihistamines. Over 20,000 (25%) of all new breast cancer cases each yr could be preventable if this hypothesis is correct.
KW - Alcohols, ethyl--toxicity-;
KW - Toxicity--alcohols, ethyl--studies, cancer, mechanism of action, hypothesis;
KW - Mechanism of action--alcohols, ethyl--cancer, toxicity studies, hypothesis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - NICHOLS, WARREN W.
AU - MURPHY, DONALD G.
T1 - Cell Bank Established.
JO - Science
JF - Science
Y1 - 1976/05/14/
VL - 192
IS - 4240
M3 - Article
SP - 615
EP - 615
SN - 00368075
N1 - Accession Number: 85233137; NICHOLS, WARREN W. 1; MURPHY, DONALD G. 2; Affiliations: 1: Department of Cytogenetices, Institute for Medical Research, Camden, New Jersey 08103; 2: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/14/1976, Vol. 192 Issue 4240, p615; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Siris, E. S.;
AU - Leventhal, B. G.;
AU - Vaitukaitis, J. L.;
T1 - Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls
CT - Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/05/20/
VL - 294
IS - May 20
SP - 1143
EP - 1146
SN - 00284793
AD - Reproduction Research Branch, National Institute of Child Health and Human Development, Bldg. 10, Rm. 10B09, Bethesda, Maryland 20014
N1 - Accession Number: 13-4818; Language: English; Chemical Name: Vincristine--57-22-7 Methotrexate--59-05-2 Mercaptopurine--6112-76-1 Cyclophosphamide--6055-19-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents mercaptopurine (10:00); AHFS Class: Antineoplastic agents cyclophosphamide; References: 25; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2 - Longer survival in childhood leukemia prompted this study of pubertal development and reproductive function in 35 girls and women who were treated with various chemotherapeutic agents (steroids, vincristine, methotrexate, mercaptopurine and cyclophosphamide). Twenty-eight patients (80%) had normal pubertal progression during a median of 74 months after diagnosis of leukemia and 49 months of chemotherapy. Seven patients were abnormal: 4 exhibited hypothalamicpituitary dysfunction with suppression of circulating serum gonadotropins (\LT/ 6 mIU/ml); 3 others had evidence of primary ovarian dysfunction\M/reversible in 2\M/with inappropriately elevated circulating serum gonadotropins (follicle stimulating hormone \GT/ 20 mIU/ml). Normal sexual development correlated best with pubertal status at onset of leukemia; only one of 17 patients with diagnosis before puberty experienced altered pubertal progression, whereas abnormalities appeared in 6 to 18 with onset during puberty or after menarche. Thus, most girls with aggressively treated childhood leukemia have an excellent prognosis for normal hypothalamic-pituitary-ovarian function; normal development is further enhanced in patients who are prepubertal at onset of leukemia.
KW - Vincristine--toxicity-;
KW - Methotrexate--toxicity-;
KW - Mercaptopurine--toxicity-;
KW - Cyclophosphamide--toxicity-;
KW - Steroids--toxicity--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Toxicity--steroids--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Toxicity--vincristine--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Toxicity--methotrexate--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Toxicity--mercaptopurine--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Toxicity--cyclophosphamide--studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Antineoplastic agents--vincristine--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Antineoplastic agents--methotrexate--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Antineoplastic agents--mercaptopurine--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
KW - Antineoplastic agents--cyclophosphamide--toxicity, studies, lack, effects, on pubertal development and reproductive function, in female patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Whitley, R. J.;
AU - Chien, L. T.;
AU - Dolin, R.;
AU - Galasso, G. J.;
AU - Alford, C. A.;
AU - \ET/;
T1 - Adenine arabinoside therapy of herpes zoster in the immunosuppressed: National Institute of Allergy and Infectious Diseases (NIAID) collaborative antiviral study
CT - Adenine arabinoside therapy of herpes zoster in the immunosuppressed: National Institute of Allergy and Infectious Diseases (NIAID) collaborative antiviral study
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/05/27/
VL - 294
IS - May 27
SP - 1193
EP - 1199
SN - 00284793
AD - Reprints: Univ. of Alabama in Birmingham, P.O. Box 313, Rm. 609, C.D.L.D. Bldg., Univ. Station, Birmingham, Alabama 35294
AD - Depts. of Pediatrics, Microbiology and Clinical Research, Univ. of Alabama in Birmingham, and the National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 13-4846; Language: English; Chemical Name: Adenine--73-24-5; Therapeutic Class: (8:18); AHFS Class: Virucides adenine; References: 31; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Adenine arabinoside (I) treatment of herpes zoster was evaluated in 87 immunodeficient patients in a randomized, controlled crossover study. Patients in group A received I for 5 days followed by placebo for the remaining 5 days. Group B patients received the opposite regimen. I was administered IV over 12 hr at a dosage of 10 mg/kg/day. I was supplied in 5 ml vials at a concentration of 200 mg/ml and because of its low solubility was diluted in standard IV solutions so that the final concentration did not exceed 0.7 mg/ml. In spite of rapid natural healing, those receiving I over the first 5 days had accelerated clearance of virus from vesicles (P = 0.01), and cessation of new vesicle formation (P = 0.004), and a shorter time to total pustulation (P = 0.01). Factors modifying the response to therapy included age, underlying disease, and the duration of zoster prior to therapy. Clinical toxicity was minimal. Laboratory assessment of bone marrow, liver and renal function showed insignificant alterations as a result of therapy. These studies show that I is a drug with promise for therapy of systemic herpes zoster in immunocompromised patients. I is most efficacious when administered during the first 6 days of disease (P = 0.001) to those who have reticuloendothelial neoplasia (P = 0.001) and are less than 38 yr of age (P = 0.001).
KW - Adenine--arabinoside-;
KW - Virucides--adenine--arabinoside, herpes zoster therapy, in immunodeficient patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kopanda, R. T.;
AU - Post, R. M.;
T1 - Cocaine, kindling, and psychosis
CT - Cocaine, kindling, and psychosis
JO - American Journal of Psychiatry (USA)
JF - American Journal of Psychiatry (USA)
Y1 - 1976/06/01/
VL - 133
IS - Jun
SP - 627
EP - 634
SN - 0002953X
AD - Bldg. 10, Rm. 3S239, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 14-0038; Language: English; Chemical Name: Cocaine--50-36-2; References: 100; Publication Type: Review; Journal Coden: AJPSAO; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: David M. Iamkis
N2 - A review of evidence indicating that repetitive administration of central nervous system stimulants and other related compounds may be associated with progressive alterations of behavior is presented. It is suggested that psychopathological behavior may be related to an electrical kindling phenomenon in which repetitive subthreshold stimulation of the limbic system is eventually associated with major motor seizures. Studies supporting a pharmacological kindling mechanism by cocaine and amphetamine that produces a psychosis are reviewed, and a discussion of a psychosis model that relates catecholamines, a limbic system focus, and a kindling mechanism is presented.
KW - Cocaine--dosage schedules-;
KW - Central nervous system stimulants--dosage schedules--adverse reactions, behavioral alterations, review, humans;
KW - Dosage schedules--central nervous system stimulants--adverse reactions, behavioral alterations, review, humans;
KW - Drugs, adverse reactions--central nervous system stimulants--dosage schedules, behavioral alterations, review, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kohn, Melvin L.
T1 - SOCIAL CLASS AND PARENTAL VALUES: ANOTHER CONFIRMATION OF THE RELATIONSHIP.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1976/06//
VL - 41
IS - 3
M3 - Article
SP - 538
EP - 545
SN - 00031224
AB - The article provides another assessment of the relationship between social class and parental values. The Robert Lynds in their classic community study, "Middletown", initially described the relationship between social class and parental values. The class-values relationship was reconfirmed, and more precisely described, in Melvin L. Kohn's study of Washington, D.C. and was again confirmed, and considerably extended, in Kohn and Carmi Schooler's study of a cross section of fathers throughout the U.S. James D. Wrights' confirm that fathers' social class position is related to their valuation of self-direction for children and that the size of the correlation is remarkably close to what was originally found. They also confirm that the class-values relationship remains substantial even when all other major lines of social demarcation are statistically controlled. They even confirm that social class, controlled on all other major lines of social demarcation, is as strongly related to fathers' valuation of self-direction as are all other major lines of social demarcation combined, controlled only on social class.
KW - SOCIAL classes
KW - VALUES (Ethics)
KW - AESTHETICS
KW - AUTONOMY (Psychology)
KW - FATHER & child
KW - FATHERS
N1 - Accession Number: 15273255; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun76, Vol. 41 Issue 3, p538; Subject Term: SOCIAL classes; Subject Term: VALUES (Ethics); Subject Term: AESTHETICS; Subject Term: AUTONOMY (Psychology); Subject Term: FATHER & child; Subject Term: FATHERS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Kohn, Melvin L.
T1 - REPLY TO WRIGHT AND WRIGHT.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1976/06//
VL - 41
IS - 3
M3 - Article
SP - 548
EP - 548
SN - 00031224
AB - The article presents reply to sociologist James D. Wright and Sonia R. Wright. by Melvin L. Kohn on his comment on the article entitled "social class and parental values for children." Wrights acknowledge--implicitly, by abandoning their original arguments--that the 1973 NORC data cast no doubt on the thesis of the original study. They add, ingenuously, that they never intended to imply otherwise. There are still several secondary issues that separate the view--for example, whether there has been change in paternal valuation of self-direction in the past decade and whether Kohn's use of disparate variables in separate analyses for diverse purposes somehow justifies the Wrights' lumping all these variables together as if they were a meaningful conceptual entity. Moreover, they still ignore both the discussion of social structural variables other than social class in "Class and Conformity" and Carmi Schooler's more extended analysis and interpretation of these variables in subsequent publications.
KW - SOCIAL structure
KW - SOCIAL classes
KW - VALUES (Ethics)
KW - AUTONOMY (Psychology)
KW - CHILDREN
KW - CONFORMITY
KW - SOCIAL influence
N1 - Accession Number: 15273257; Kohn, Melvin L. 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Jun76, Vol. 41 Issue 3, p548; Thesaurus Term: SOCIAL structure; Subject Term: SOCIAL classes; Subject Term: VALUES (Ethics); Subject Term: AUTONOMY (Psychology); Subject Term: CHILDREN; Subject Term: CONFORMITY; Subject Term: SOCIAL influence; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Legha, S.;
AU - Muggia, F. M.;
T1 - Antiestrogens in the treatment of cancer
CT - Antiestrogens in the treatment of cancer
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/06/01/
VL - 84
IS - Jun
SP - 751
SN - 00034819
AD - Cancer Therapy Evaluation, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 14-0399; Language: English; References: 6; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Teresa A. Dunlap
N2 - Some preliminary, unpublished clinical data on the usefulness of antiestrogens in the treatment of various disseminated malignancies are presented. It is recommended that antiestrogens should be investigated in the treatment of cancers of the kidney, prostate, endometrium as well as carcinomas of the ovary, vagina and cervix, since these are also tumors that arise from estrogen target tissues.
KW - Anti-estrogens--cancer--therapy, patients;
KW - Antineoplastic agents--anti-estrogens--cancer, therapy, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Jacobs, Blanche S.
AU - Moss, Howard A.
T1 - Birth Order and Sex of Sibling as Determinants of Mother-Infant Interaction.
JO - Child Development
JF - Child Development
Y1 - 1976/06//
VL - 47
IS - 2
M3 - Article
SP - 315
EP - 322
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12189663; Jacobs, Blanche S. 1 Moss, Howard A. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1976, Vol. 47 Issue 2, p315; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1467-8624.ep12189663
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189663&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Raymond K.
AU - Halverson Jr., Charles F.
T1 - A Study of the "Inversion of Intensity" between Newborn and Preschool-Age Behavior.
JO - Child Development
JF - Child Development
Y1 - 1976/06//
VL - 47
IS - 2
M3 - Article
SP - 350
EP - 359
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12189700; Yang, Raymond K. 1 Halverson Jr., Charles F. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1976, Vol. 47 Issue 2, p350; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1467-8624.ep12189700
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12189700&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaoita, Hideo
AU - Gullino, Marisa
AU - Katz, Stephen I.
T1 - HERPES GESTATIONIS ULTRASTRUCTURE AND ULTRASTRUCTURAL LOCALIZATION OF IN VIVO-BOUND COMPLEMENT.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/06//
VL - 66
IS - 6
M3 - Article
SP - 383
EP - 388
SN - 0022202X
AB - Ultrastructural localization of C3 deposition in the skin of two patients with herpes gestationis was determined by using a peroxidase-antiperoxidase multistep technique. The tissue preparations can be stored for long periods of time and identical sections may be used for light and electron microscopic examination. The reaction products were seen throughout the entire lamina lucida and the basal cell plasma membrane appeared to be accentuated. The most remarkable ultrastructural changes in normal-appearing skin were the destruction of the basal cell membranes on the dermal side, localized cytoplasmic dissolution, and intracellular edema unaccompanied by inflammatory cells. Early, nonvesicular lesions showed basal cell degeneration and dermal inflammatory cells. Necrosis and loss of basal cells occurred in the next stage which resulted in microvesieles in which collagen or a well-preserved basal lamina formed the vesicle base. In the later blister stage, the basal lamina was usually lost. It is suggested that damage of basal cell membranes on their dermal side leads to the destruction of basal cells with the subsequent protrusion of epidermal and junctional substances into the dermis. This may result in inflammatory cell infiltration and blister formation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPESVIRUS diseases
KW - DERMIS
KW - CELL membranes
KW - CELLS
KW - ENZYMES
KW - EDEMA
N1 - Accession Number: 12483011; Yaoita, Hideo 1 Gullino, Marisa 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun76, Vol. 66 Issue 6, p383; Subject Term: HERPESVIRUS diseases; Subject Term: DERMIS; Subject Term: CELL membranes; Subject Term: CELLS; Subject Term: ENZYMES; Subject Term: EDEMA; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12483011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Mulvihill, J. J.;
AU - Yeager, A. M.;
T1 - Fetal alcohol syndrome
CT - Fetal alcohol syndrome
JO - Teratology (USA)
JF - Teratology (USA)
Y1 - 1976/06/01/
VL - 13
IS - Jun
SP - 345
EP - 348
SN - 00403709
AD - Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-6076; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 4; Journal Coden: TJADAB; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: William A. Parker
N2 - The clinical manifestations, etiology, pathogenesis, treatment, and prevention of the fetal alcohol syndrome are discussed.
KW - Alcohols, ethyl--teratogenicity-;
KW - Teratogenicity--alcohols, ethyl--syndromes, growth retardation and physical anomalies, following maternal ingestion;
KW - Placental transfer--alcohols, ethyl--teratogenicity, syndromes, growth retardation and physical anomalies, following maternal ingestion;
KW - Toxicity--alcohols, ethyl--teratogenicity, syndromes, growth retardation and physical anomalies, following maternal ingestion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - CALLAHAN, ROBERT
AU - LIEBER, MICHAEL M.
AU - TODARO, GEORGE J.
AU - GRAVES, DONALD C.
AU - FERRER, JORGE F.
T1 - Bovine Leukemia Virus Genes in the DNA of Leukemic Cattle.
JO - Science
JF - Science
Y1 - 1976/06/04/
VL - 192
IS - 4243
M3 - Article
SP - 1005
EP - 1007
SN - 00368075
AB - Reverse transcripts of the RNA genome of the bovine leukemia virus (BLV) as well as 125I-labeled BLV RNA hybridize to the DNA of tissues from leukemic cattle with the adult form of the disease but not to bovine thymic lymphoma or normal bovine tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85360915; CALLAHAN, ROBERT 1; LIEBER, MICHAEL M. 1; TODARO, GEORGE J. 1; GRAVES, DONALD C. 2; FERRER, JORGE F. 2,3; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute; 2: National Institutes of Health, Bethesda, Maryland 20014; 3: University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square 19348; Issue Info: 6/ 4/1976, Vol. 192 Issue 4243, p1005; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PEEBLES, PAUL T.
AU - SCOLNICK, EDWARD M.
AU - HOWK, RICHARD S.
T1 - Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis.
JO - Science
JF - Science
Y1 - 1976/06/11/
VL - 192
IS - 4244
M3 - Article
SP - 1143
EP - 1145
SN - 00368075
AB - A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85360958; PEEBLES, PAUL T. 1; SCOLNICK, EDWARD M. 1; HOWK, RICHARD S. 2; Affiliations: 1: Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland 20014; 2: Meloy Laboratories, Rockville, Maryland 20850; Issue Info: 6/11/1976, Vol. 192 Issue 4244, p1143; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06288-036
AN - 2006-06288-036
AU - DuPont, Robert L.
AU - Ginzburg, Harold M.
T1 - The Confusing State of Drug Abuse Evaluation.
JF - Contemporary Psychology: APA Review of Books
JO - Contemporary Psychology: APA Review of Books
Y1 - 1976/07//
VL - 21
IS - 7
SP - 500
EP - 501
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06288-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: DuPont, Robert L.; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Treatment Effectiveness Evaluation. Minor Descriptor: Health; Social Programs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I=Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50; 1974. Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2=Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50; 1974. Page Count: 2. Issue Publication Date: Jul, 1976.
KW - drug abuse treatment
KW - treatment effectiveness
KW - health programs
KW - social programs
KW - 1976
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Treatment Effectiveness Evaluation
KW - Health
KW - Social Programs
U2 - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I; Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50
U2 - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2; Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50
DO - 10.1037/015270
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pvh&AN=2006-06288-036&site=ehost-live&scope=site
DP - EBSCOhost
DB - pvh
ER -
TY - JOUR
TY - GEN
AU - Mahal, A. S.;
AU - Malik, S. C.;
AU - Srinivasamurthy, U.;
T1 - Evaluation of loxapine succinate as an anxiolytic in comparison with chlordiazepoxide
CT - Evaluation of loxapine succinate as an anxiolytic in comparison with chlordiazepoxide
JO - Curr. Ther. Res. Clin. Exp.
JF - Curr. Ther. Res. Clin. Exp.
Y1 - 1976/07/01/
VL - 20
IS - Jul
SP - 84
EP - 93
AD - National Institute of Mental Health and Nuero Sciences, Bangalore, 560 027 India
N1 - Accession Number: 14-4447; Language: English; Chemical Name: Loxapine--1977-10-2 Chlordiazepoxide--58-25-3; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers chlordiazepoxide, comparison, loxapine (28:16.08); AHFS Class: Tranquilizers loxapine, comparison, chlordiazepoxide; References: 6; Journal Coden: CTCEA9; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The therapeutic effects of loxapine succinate (I) 6-8 mg/day, were compared in a double blind study with those of chlordiazepoxide (II), 50-60 mg/day, in 60 anxious patients. Forty-two patients completed the 4 week study, 20 from the I group and 22 from the II group. Assessment was done weekly on the Hamilton Rating Scale for Anxiety and Self Rating Symptom Scale (Lipman). After evaluating these patients who were on the active drug, it was found that both the drugs were equally effective. Minor side effects which did not necessitate interruption of treatment were observed in both groups, and appeared comparable, consisting mainly of sedation, tremor, and anticholinergic effects.
KW - Loxapine--comparison, chlordiazepoxide-;
KW - Chlordiazepoxide--comparison, loxapine-;
KW - Tranquilizers--chlordiazepoxide, comparison, loxapine--anxiety, therapy, and side effects, patients;
KW - Tranquilizers--loxapine, comparison, chlordiazepoxide--anxiety, therapy, and side effects, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Butler, Robert N.
T1 - The teaching of geriatric medicine.
JO - Geriatrics
JF - Geriatrics
Y1 - 1976/07//
VL - 31
IS - 7
M3 - Article
SP - 35
EP - 35
SN - 0016867X
N1 - Accession Number: 18942155; Butler, Robert N. 1; Source Information: Jul1976, Vol. 31 Issue 7, p35; Number of Pages: 1/2p; Document Type: Article; Full Text Word Count: 532
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hunninghake, G. W.
AU - Fauci, A. S.
T1 - Quantitative and qualitative effects of cyclophosphamide administration on circulating polymorphonuclear leucocytes.
JO - Immunology
JF - Immunology
Y1 - 1976/07//
VL - 31
IS - 1
M3 - Article
SP - 139
EP - 144
PB - Wiley-Blackwell
SN - 00192805
AB - The effect of cyclophosphamide (CY) on the absolute numbers and function of polymorphonuclear leucocytes (PMN) surviving in the circulation following either a single dose (100 mg/kg, i.p.) or daily administration (20 mg/kg, i.p., for 5 days) was studied in the guinea-pig. The quantitative effect of CY on peripheral blood leucocytes was assessed by measuring the absolute numbers of neutrophils, lymphocytes, and monocytes daily for 5 days following the initial injection of CY. The qualitative effects of CY on PMN function were determined by measuring the ability of these cells to function as killer cells. The two functional assays employed were the PMNmediated PHA-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) assays against chicken erythrocyte targets. Both regimens of CY administration produced an equivalent degree of leukopenia 5 days after the initial injection with disproportionately severe neutropenia (<300 PMN/mm³). However, neither regimen of CY administration produced a significant decrease in cytotoxic effector function as measured through a wide range of effector to target cell ratios, PHA concentrations, and antiserum dilutions. These findings have clinical relevance in that they demonstrate the dichotomy between the quantitative and qualitative effects of (CY) on PMNs in that CY administration can dramatically decrease the absolute numbers of circulating polymorphonuclear leucocytes while leaving intact certain effector cell functional capabilities of those PMN surviving in the circulation during drug administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBODY-dependent cell cytotoxicity
KW - MONOCYTES
KW - LYMPHOCYTES
KW - NEUTROPHILS
KW - KILLER cells
KW - ONTOLOGY
N1 - Accession Number: 13362743; Hunninghake, G. W. 1 Fauci, A. S. 1; Affiliation: 1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul76, Vol. 31 Issue 1, p139; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: MONOCYTES; Subject Term: LYMPHOCYTES; Subject Term: NEUTROPHILS; Subject Term: KILLER cells; Subject Term: ONTOLOGY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, Edward F.
AU - Murphy, Dennis L.
AU - Waldman, Ivan N.
AU - Reynolds, Thomas D.
T1 - MMPI DIFFERENCES BETWEEN UNIPOLAR AND BIPOLAR DEPRESSED SUBJECTS: A REPLICATION.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1976/07//
VL - 32
IS - 3
M3 - Article
SP - 610
EP - 612
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article discusses MMPI, that differences between unipolar and bipolar depressed subjects. Significant differences between groups were found on scales D and PT, but not on MA. Further, scales K, HS, HY, PA, and SI also significantly differentiated the two groups in this study. While the initial study showed sex-related differences on the HS scale only, this study showed that unipolar males had significantly higher scores than unipolar females on scales D, PD, PT, and MA, but unipolar females had significantly higher scores on the SI scale. Bipolar males and females were not differentiated on any scales. It was suggested that differences between groups might be a function of higher anxiety in the unipolar group.
KW - MINNESOTA Multiphasic Personality Inventory
KW - FEMALES
KW - ANXIETY
KW - STRESS (Psychology)
KW - BIPOLAR disorder
KW - MENTAL depression
KW - GENDER studies
N1 - Accession Number: 15844942; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Waldman, Ivan N. 3 Reynolds, Thomas D. 3; Affiliation: 1: Saint Elizabeths Hospital Washington, DC. 2: National Institute of Menial Health Bethesda, Md. 3: National Institute of Mental Health Washington, D.C.; Source Info: Jul1976, Vol. 32 Issue 3, p610; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: FEMALES; Subject Term: ANXIETY; Subject Term: STRESS (Psychology); Subject Term: BIPOLAR disorder; Subject Term: MENTAL depression; Subject Term: GENDER studies; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuspa, Stuart H.
AU - Hennings, Henry
AU - Saffiotti, Umberto
T1 - CUTANEOUS CHEMICAL CARCINOGENESIS: PAST, PRESENT, AND FUTURE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/07//
VL - 67
IS - 1
M3 - Article
SP - 199
EP - 208
SN - 0022202X
AB - Skin tumors chemically induced in mice have provided an important experimental model for studying carcinogenesis and for bioassaying carcinogenic agents. The information obtained from this model suggests that the events leading to tumor formation can be divided into at least two stages, initiation and promotion. A single small. dose of carcinogen produces initiation which appears to be irreversible. These initiating agents may have to be metabolically activated and can interact with cellular macromolecules. The extent to which they bind to DNA correlates well with their carcinogenicity. Increased DNA replication at the time of or during the first day after these agents have been applied appears to enhance carcinogenesis. Unlike initiation, promotion appears to be reversible and the promoting agents must be applied repeatedly before tumors are formed. Promoters interact with membranes, stimulate and alter genetic expression, and increase the rate of cell proliferation. The knowledge gained from these studies in mouse skin has immeasurably helped the entire field of chemical carcinogenesis. But efforts to determine the cellular and molecular mechanisms involved in the carcinogenic process, particularly in the skin, have been hampered by the difficulties of working on whole animals and by the special problems associated with the biologic and biochemical methods required for this target organ. Such problems, however, can be solved by the use of cell cultures of mouse epidermis which can metabolize and bind carcinogens just as is done in vivo. The fact that epidermal cells in vitro proliferate synchronously should facilitate the study of the relation between the cell cycle and carcinogenesis. These cells repair chemically induced DNA damage by at least two mechanisms, excision repair and base-specific repair. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMORS
KW - MICE
KW - DNA
KW - CELL proliferation
KW - CELL culture
KW - CARCINOGENS
N1 - Accession Number: 12513040; Yuspa, Stuart H. 1 Hennings, Henry 1 Saffiotti, Umberto 1; Affiliation: 1: In Vitro Pathogenesis Section, Experimental Pathology Branch ( Carcinogenesis), Division of Cancer Cause and Prevention, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Jul76, Vol. 67 Issue 1, p199; Subject Term: TUMORS; Subject Term: MICE; Subject Term: DNA; Subject Term: CELL proliferation; Subject Term: CELL culture; Subject Term: CARCINOGENS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1523-1747.ep12513040
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Wooster, Harold1
T1 - The Case Rests.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
J1 - Journal of the American Society for Information Science
PY - 1976/07//Jul/Aug1976
Y1 - 1976/07//Jul/Aug1976
VL - 27
IS - 4
CP - 4
M3 - Letter
SP - 264
EP - 264
SN - 00028231
AB - Presents a letter to the editor in response to an article about the use of library materials, published in a previous issue of the "Journal of the American Society for Information Science."
KW - Information science
KW - Periodicals
KW - Letters to the editor
N1 - Accession Number: 16757962; Authors: Wooster, Harold 1; Affiliations: 1: Special Assistant for Program Development, Lister Hill National Center for Biomedical Communications,National Institutes of Health, Bethesda, MD 20014; Subject: Letters to the editor; Subject: Information science; Subject: Periodicals; Number of Pages: 1/6p; Record Type: Letter
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DP - EBSCOhost
DB - lls
ER -
TY - GEN
AU - Graepel, P H
T1 - Automatic indexing of german language surgical pathology diagnoses
JO - Methods of Information in Medicine
JF - Methods of Information in Medicine
Y1 - 1976/07//
VL - 15
IS - 3
M3 - Article
SP - 163
EP - 167
SN - 00261270
AB - Based on experiences with an existing automatic encoding system for english and french language medical data, a simple automatic indexing program for german language surgical pathology diagnoses has been developed. A dictionary of sample index-terms has created reflecting basic information items in an individual user's vocabulary. The dictionary is based on the semantic categorization of the systematized nomenclature of pathology (snop) and open to any numeric coding scheme within this semantic framework. The results of the automatic encoding allow the retrieval of documents (surgical pathology reports) according to practical needs of pathologists and provide an opportunity to study and possibly improve the systematic structure of medical nomenclatures.
N1 - Accession Number: ISTA1103766; Graepel, P H 1; Affiliations: 1 : National Cancer Institute And Division Of Computer Research And Technology, National Institutes Of Health, Bethesda, Maryland; Source Info: July 1976, Vol. 15 Issue 3, p163; Note: Update Code: 1100; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Engel, Bernard T.
AU - Gottlieb, Sheldon H.
AU - Hayhurst, Viola F.
T1 - Tonic and Phasic Relationships Between Heart Rate and Somato-motor Activity in Monkeys.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1976/07//
VL - 13
IS - 4
M3 - Article
SP - 288
EP - 295
SN - 00485772
AB - Heart rate (HR) and somato-motor activity were measured in monkeys (Macaca mulatta) during sessions when the animals were operantly conditioned to stow and to speed HR. Tonic (baseline) levels of HR were independent of somato-motor activity. Phasic changes of HR during conditioning were variably coupled with phasic changes in activity. The discriminative cues which signalled the operant contingencies reliably elicited cardiac operants and somato-motor responses. Monotonic trends in cardiac phasic activity generally were independent of phasic responses in somato-motor activity. Short term phasic responses in HR often were correlated with short term phasic responses in somato-motor responses. The findings indicate that the relationship of HR to somato-motor activity depends upon temporal adjustments within given conditions and stages of training, and upon particular adjustments within each animal. The main conclusion of this study is that HR and somato-motor activity are variably coupled but that conditioned HR responses are not necessarily caused by somato-motor responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART beat
KW - MOTOR ability
KW - TEMPORAL lobes
KW - ANIMAL experimentation
KW - PSYCHOPHYSIOLOGY
KW - PHYSIOLOGY
KW - Heart rate
KW - Operant conditioning
KW - Somato-motor activity.
N1 - Accession Number: 11728811; Engel, Bernard T. 1,2,3 Gottlieb, Sheldon H. 1,2,3 Hayhurst, Viola F. 1,2,3; Affiliation: 1: Gerontology Research Center (Baltimore), National Institute on Aging, National Institute of Health, PHS 2: U.S. Department of Health, Education, and Welfare, Bethesda 3: Baltimore City Hospitals; Source Info: Jul1976, Vol. 13 Issue 4, p288; Subject Term: HEART beat; Subject Term: MOTOR ability; Subject Term: TEMPORAL lobes; Subject Term: ANIMAL experimentation; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Somato-motor activity.; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-8986.ep11728811
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11728811&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06288-036
AN - 2006-06288-036
AU - DuPont, Robert L.
AU - Ginzburg, Harold M.
T1 - The Confusing State of Drug Abuse Evaluation.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1976/07//
VL - 21
IS - 7
SP - 500
EP - 501
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06288-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: DuPont, Robert L.; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Treatment Effectiveness Evaluation. Minor Descriptor: Health; Social Programs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Reviewed Item: Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I=Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50; 1974. Sells, S. B. (Ed). The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2=Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50; 1974. Page Count: 2. Issue Publication Date: Jul, 1976.
AB - Reviews the books, The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I edited by S. B. Sells (1974) and The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2 edited by S. B. Sells (1974). The measurement of treatment effectiveness is one of the most important aspects of contemporary health and social programs. Drug-abuse treatment has been in the forefront of assessment efforts, partly because the controversy surrounding drug abuse led to attempts to 'prove' that treatment worked and partly because the objectives in drug-abuse treatment were clearer than in many other program areas. Saul Sells and his group have been leaders in the efforts to develop new assessment tools. His initial efforts reported in these volumes will confuse many readers because of the complexity of the problems addressed. Nevertheless, no reader should overlook the importance 'of this contribution to the literature of treatment assessment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug abuse treatment
KW - treatment effectiveness
KW - health programs
KW - social programs
KW - 1976
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Treatment Effectiveness Evaluation
KW - Health
KW - Social Programs
KW - 1976
U2 - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Evaluation of Treatments, Vol. I; Cambridge: Mass.: Ballinger, 1974. Pp. xxxviii + 532. $18.50
U2 - Sells, S. B. (Ed). (1974); The Effectiveness of Drug Abuse Treatment: Research on Patients, Treatments, and Outcomes, Vol. 2; Cambridge, Mass.: Ballinger, 1974. Pp. xxx + 413. $16.50
DO - 10.1037/015270
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06288-036&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42174-024
AN - 2013-42174-024
AU - Shore, Milton F.
T1 - Review of The awareness trap: Self-absorption instead of social change.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/07//
VL - 46
IS - 3
SP - 552
EP - 553
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42174-024. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gestalt Therapy; Meditation; Psychotherapy; Social Change. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Reviewed Item: Schur, Edwin. The awareness trap: Self-absorption instead of social change=213 pp. $7.95. Quadrangle, New York; 1976. Page Count: 2. Issue Publication Date: Jul, 1976.
AB - Reviews the book, The Awareness Trap: Self-Absorption Instead of Social Change by Edwin Schur (see record [rid]1978-08207-000[/rid]). As suggested by its title, this book is an angry indictment of a growing cult in the United States, that of self-gratification psychotherapies such as transcendental meditation, primal scream, encounter groups, nude marathons, gestalt therapy, personal growth groups, and bio-energetics. The author fears that a preoccupation with one’s own experiences at the expense of other people and larger social goals, and a lack of understanding of the role institutional structures play in pathology, will destroy the positive features of the women’s movement and the youth movement, both of which have tried to alter destructive social forces through legal and political challenges. But the author’s anger is a handicap. Rather than developing a thoughtful historical, conceptual, or sociological analysis of why certain groups in our society have become involved in asocial ways of dealing with the world, he uses debate, emotional appeal, persuasion, and argumentation. The author primarily employs select quotations from various sources pieced together in journalistic style, as if he were pleading a case. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self-absorption
KW - social change
KW - self-gratification
KW - psychotherapy
KW - meditation
KW - gestalt therapy
KW - 1976
KW - Gestalt Therapy
KW - Meditation
KW - Psychotherapy
KW - Social Change
KW - 1976
U2 - Schur, Edwin. (1976); The awareness trap: Self-absorption instead of social change; 213 pp. $7.95. Quadrangle, New York
DO - 10.1037/h0098933
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42174-030
AN - 2013-42174-030
AU - Wiener, Jack
T1 - Review of Freud and his followers.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/07//
VL - 46
IS - 3
SP - 563
EP - 565
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42174-030. Partial author list: First Author & Affiliation: Wiener, Jack; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Biographical Data; Freud (Sigmund); Psychoanalysts; Psychoanalytic Theory. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Roazen, Paul. Freud and his followers=599 pp. $15.00. Alfred A. Knopf, New York; 1975. Page Count: 3. Issue Publication Date: Jul, 1976.
AB - Reviews the book, Freud and His Followers by Paul Roazen (see record [rid]1975-20049-000[/rid]). Besides the biographical information, a good deal of the book is devoted to Freud’s ideas and those of his followers-many of whom had bitter quarrels with Freud and were banished from Freud’s psychoanalytic group. The book contains new material about Freud from oral interviews with 70 people who knew Freud personally. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Sigmund Freud
KW - biographical information
KW - psychoanalytic groups
KW - 1976
KW - Biographical Data
KW - Freud (Sigmund)
KW - Psychoanalysts
KW - Psychoanalytic Theory
KW - 1976
U2 - Roazen, Paul. (1975); Freud and his followers; 599 pp. $15.00. Alfred A. Knopf, New York
DO - 10.1037/h0098939
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-030&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42174-032
AN - 2013-42174-032
AU - Barrett, David E.
T1 - Death penalty discriminators.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/07//
VL - 46
IS - 3
SP - 566
EP - 568
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42174-032. Partial author list: First Author & Affiliation: Barrett, David E.; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Capital Punishment; Juries; Racial and Ethnic Differences; Rape. Minor Descriptor: Judges; Legal Processes. Classification: Criminal Law & Adjudication (4230). Population: Human (10). Page Count: 3. Issue Publication Date: Jul, 1976.
AB - Comments on an article by Marvin E. Wolfgang & Marc Riedel (see record [rid]2013-41586-014[/rid]). Wolfgang and Riedel which of several variables were most useful in discriminating between convicted rapists who received the death penalty and those who did not. The variables of interest included characteristics of the defendant and the victim, as well as characteristics of the offense and of the trial proceedings. Based on their analysis, the authors concluded that the variable representing the combination of race of defendant and race of victim best discriminated between the two groups, while neither race of defendant nor race of victim, considered alone, was a significant discriminating variable. However, the results of the discriminant analysis reported by the authors are themselves inconclusive. The variable racial combination of defendant/victim was constructed to test for a statistical interaction between race of defendant and race of victim with regard to death sentence imposition. To determine the contribution to discrimination of such a variable, it is necessary first to account for the separate contributions of the two 'main effect' variables. The authors’ failure to do so precludes the possibility of determining whether the contribution of racial combination per se, over and above the contributions made by the two racial variables considered singly, is significant. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - capital punishment
KW - death penalty
KW - racial differences
KW - rape
KW - judge
KW - legal variables
KW - juries
KW - 1976
KW - Capital Punishment
KW - Juries
KW - Racial and Ethnic Differences
KW - Rape
KW - Judges
KW - Legal Processes
KW - 1976
DO - 10.1037/h0098940
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42174-032&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - CHUANG, D. M.
AU - HOLLENBECK, R.
AU - COSTA, E.
T1 - Enhanced Template Activity in Chromatin from Adrenal Medulla After Phosphorylation of Chromosomal Proteins.
JO - Science
JF - Science
Y1 - 1976/07/02/
VL - 193
IS - 4247
M3 - Article
SP - 60
EP - 62
SN - 00368075
AB - Translocation of protein kinase to the nucleus had been implicated earlier in the transsynaptic control of gene expression mediated by cholinergic nerves in adrenal medulla. Phosphorylation of chromosomal proteins by adenosine 3',5'-monophosphate-dependent protein kinase and adenosine 3',5'-monophosphate enhances the template activity of chromatin from adrenal medulla. When homologous RNA polymerase II is used the relative activation is greater than that obtained with Escherichia coli RNA polymerase. The substrate for such phosphorylation does not seem to be RNA polymerase II. Phosphorylation of specific acidic protein probably mediates this enhancement of template activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361035; CHUANG, D. M. 1; HOLLENBECK, R. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 7/ 2/1976, Vol. 193 Issue 4247, p60; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SEIFTER, ELI
AU - COHEN, MAX H.
AU - RILEY, VERNON
T1 - Of Stress, Vitamin A, and Tumors.
JO - Science
JF - Science
Y1 - 1976/07/02/
VL - 193
IS - 4247
M3 - Article
SP - 74
EP - 75
SN - 00368075
N1 - Accession Number: 85361042; SEIFTER, ELI 1; COHEN, MAX H. 2; RILEY, VERNON 3; Affiliations: 1: Departments of Biochemistry and Surgery, Albert Einstein College of Medicine, Yeshiva University Bronx, New York 10461; 2: Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014; 3: Department of Microbiology, Pacific Northwest Research Foundation, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98104; Issue Info: 7/ 2/1976, Vol. 193 Issue 4247, p74; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Byar, D. P.;
AU - Simon, R. M.;
AU - Friedewald, W. T.;
AU - Schlesselman, J. J.;
AU - DeMets, D. L.;
AU - \ET/;
T1 - Randomized clinical trials: perspectives on some recent ideas
CT - Randomized clinical trials: perspectives on some recent ideas
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/07/08/
VL - 295
IS - Jul 8
SP - 74
EP - 80
SN - 00284793
AD - Biometry Branch, Clinical and Diagnostic Trials Section, National Cancer Institute, Landow Bldg., Rm. C-509, Bethesda, Maryland 20014
N1 - Accession Number: 13-5654; Language: English; References: 30; Journal Coden: NEJMAG; Section Heading: Methodology
N2 - In spite of the controversy over the role of randomized clinical trials in medical research, the rationale underlying such trials remains persuasive as compared to recent suggestions for alternative nonrandomized studies such as those relying on the use of historical controls and adjustment techniques. It has been suggested that recent statistical innovations for improving clinical trials, including adaptive allocation of treatment to patients and sequential stopping procedures, are underutilized. These innovations, though theoretically interesting, are not easily adapted to large-scale, complex medical trials in which there may be multiple end points and delayed response times. Ethical considerations suggest that randomized trials are more suitable than uncontrolled experimentation in protecting the interest of patients. Randomized clinical trials remain the most reliable method for evaluating the efficacy of therapies.
KW - Clinical studies--randomized--discussion;
KW - Methodology--clinical studies--randomized, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5654&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hrushesky, W. J.;
T1 - Serpentine supravenous fluorouracil hyperpigmentation
CT - Serpentine supravenous fluorouracil hyperpigmentation
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/07/12/
VL - 236
IS - Jul 12
SP - 138
AD - National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-5723; Language: English; Chemical Name: Fluorouracil--51-21-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents fluorouracil; References: 4; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2 - Markedly increased pigmentation of skin immediately overlying veins used for multiple fluorouracil infusions was noted in a 56-yr-old black man with stage D carcinoma of the prostate who was treated with weekly fluorouracil doses of 750 mg/sq m for 24 consecutive weeks. The total dose of fluorouracil received was 27 g.
KW - Fluorouracil--injections-;
KW - Injections--fluorouracil--adverse reactions, skin pigmentation, cancer patient;
KW - Antineoplastic agents--fluorouracil--injections, skin pigmentation, cancer patient;
KW - Drug administration--routes--fluorouracil, injections, skin pigmentation, cancer patient;
KW - Drugs, adverse reactions--fluorouracil--injections, skin pigmentation, cancer patient;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5723&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - SINGER, MAXINE F.
AU - BERG, PAUL
T1 - Recombinant DNA: NIH Guidelines.
JO - Science
JF - Science
Y1 - 1976/07/16/
VL - 193
IS - 4249
M3 - Article
SP - 186
EP - 188
SN - 00368075
N1 - Accession Number: 88003069; SINGER, MAXINE F. 1; BERG, PAUL 2; Affiliations: 1: National Cancer Institute, National Institutes of Health Bethesda, Maryland 20014; 2: Department of Biochemistry, Stanford University Medical Center, Stanford, California 94305; Issue Info: 7/16/1976, Vol. 193 Issue 4249, p186; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SEN, ARUP
AU - TODARO, GEORGE J.
T1 - Specificity of in vitro Binding of Primate Type C Viral RNA and the Homologous Viral p12 Core Protein.
JO - Science
JF - Science
Y1 - 1976/07/23/
VL - 193
IS - 4250
M3 - Article
SP - 326
EP - 328
SN - 00368075
AB - The binding of type C viral p12 proteins to purified viral RNA has been examined in vitro with the use of a family of closely related infectious primate type C viruses-the woolly monkey (SSAV) and gibbon (GALV) group. This in vitro protein- RNA binding is type specific. The system should serve as a model for studies of the evolution of nucleic acid binding proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219969; SEN, ARUP 1; TODARO, GEORGE J. 1; Affiliations: 1: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/23/1976, Vol. 193 Issue 4250, p326; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JURGELSKI JR., WILLIAM
AU - HUDSON, PEARLIE M.
AU - FALK, HANS L.
AU - KOTIN, PAUL
T1 - Embryonal Neoplasms in the Opossum: A New Model for Solid Tumors of Infancy and Childhood.
JO - Science
JF - Science
Y1 - 1976/07/23/
VL - 193
IS - 4250
M3 - Article
SP - 328
EP - 332
SN - 00368075
AB - Opossums fed the chemical carcinogen ethyl nitrosourea early in postnatal life developed a variety of epithelial and mesenchymal embryonal neoplasms that were closely analogous, in morphology and biological behavior, to tumors of human infancy and childhood for which experimental models in laboratory animals are either imprecise or nonexistent. The embryonal tumors were found in association with, and occasionally at the same sites as, a limited number of malformations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85219970; JURGELSKI JR., WILLIAM 1; HUDSON, PEARLIE M. 1; FALK, HANS L. 1; KOTIN, PAUL 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Johns Manville Corporation, Denver, Colorado 80217; Issue Info: 7/23/1976, Vol. 193 Issue 4250, p328; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Danforth, D. N.;
AU - Triche, T.;
AU - Doppman, J. L.;
AU - Beazley, R. M.;
AU - Perrino, P. V.;
AU - \ET/;
T1 - Elevated plasma proglucagon-like component with a glucagon-secreting tumor: effect of streptozotocin
CT - Elevated plasma proglucagon-like component with a glucagon-secreting tumor: effect of streptozotocin
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/07/29/
VL - 295
IS - Jul 29
SP - 242
EP - 245
SN - 00284793
AD - Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 13-6096; Language: English; Trade Name: Streptozotocin; Generic Name: Streptozocin; Chemical Name: Streptozocin--18883-66-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents streptozocin; References: 19; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Investigational Drugs; Pharmacology
N2 - To determine the character of the glucagon secretion and its modification by streptozotocin (streptozocin; I), the plasma of a patient with recurrent pancreatic alpha-cell carcinoma was studied. The plasma immunoreactive glucagon level before treatment was 4.80 ng/ml. Biogel column separation of the plasma immunoreactive glucagon revealed 4 components; the predominant component had a molecular weight of 9000 daltons and was designated as proglucagon-like. This fraction constituted 60 to 90% of the total circulating immunoreactive glucagon, and had a biologic activity of 32% of that of an immunoequivalent amount of normal (porcine) pancreatic glucagon. After treatment with streptozotocin (1.5 g/sq m) the plasma immunoreactive glucagon level decreased to 0.24 ng/ml. Treatment was accompanied by a marked reduction in the proglucagon-like component, and the appearance of pancreatic glucagon (molecular weight of 3500 daltons) as the major post-therapy fraction. These findings support the use of I in the management of unresectable glucagon-secreting tumors.
KW - Streptozocin--tumors-;
KW - Antineoplastic agents--streptozocin--tumors, glucagon secreting, therapy, in patients;
KW - Mechanism of action--streptozocin--tumors, glucagon secreting, therapy, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6096&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mulvihill, J. J.;
AU - Klimas, J. T.;
AU - Stokes, D. C.;
AU - Risemberg, H. M.;
T1 - Fetal alcohol syndrome: seven new cases
CT - Fetal alcohol syndrome: seven new cases
JO - American Journal of Obstetrics and Gynecology (USA)
JF - American Journal of Obstetrics and Gynecology (USA)
Y1 - 1976/08/01/
VL - 125
IS - Aug 1
SP - 937
EP - 941
SN - 00029378
AD - Landow Bldg. Rm. A-521, Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 14-0678; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 16; Journal Coden: AJOGAH; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Teresa A. Martin
N2 - Seven cases of the fetal alcohol syndrome in newborn and older infants are reported.
KW - Alcohols, ethyl--toxicity-;
KW - Toxicity--alcohols, ethyl--fetal alcohol syndrome, case reports;
KW - Placental transfer--alcohols, ethyl--fetal alcohol syndrome, case reports;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0678&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Slavik, M.;
AU - Muggin, F. M.;
T1 - 5-Azacytidine: new anticancer drug with effectiveness in acute myelogenous leukemia
CT - 5-Azacytidine: new anticancer drug with effectiveness in acute myelogenous leukemia
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/08/01/
VL - 85
IS - Aug
SP - 237
EP - 245
SN - 00034819
AD - Cancer Therapy Evaluation program, Investigational Drug Branch, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-1624; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents azacytidine; References: 73; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Keith P. Lewis
N2 - A review of the laboratory, experimental animal and clinical results of the use of azacytidine is presented. Overall, azacytidine is an effective drug for the treatment of patients with acute myelogenous leukemia who have relapsed after other therapeutic approaches. However, the full potential of this drug is yet to be realized.
KW - Azacytidine--leukemias-;
KW - Antineoplastic agents--azacytidine--leukemias, acute myelogenous, therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fischman, M. W.;
AU - Schuster, C. R.;
AU - Resnekov, L.;
AU - Shick, J. F. E.;
AU - Krasnegor, N. A.;
AU - \ET/;
T1 - Cardiovascular and subjective effects of intravenous cocaine administration in humans
CT - Cardiovascular and subjective effects of intravenous cocaine administration in humans
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1976/08/01/
VL - 33
IS - Aug
SP - 983
EP - 989
AD - Reprint: Dept. of Psychiatry, Univ. of Chicago, 950 E. 59th St., Chicago, Illinois 60637
AD - Univ. of Chicago, Pritzker School of Medicine and National Institute on Drug Abuse, Rockville, Maryland
N1 - Accession Number: 14-3265; Language: English; Chemical Name: Cocaine--50-36-2 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants cocaine, comparison, dextroamphetamine (28:20); AHFS Class: Central nervous system stimulants dextroamphetamine, comparison, cocaine; References: 26; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Dose related increases in heart rate and blood pressure were measured when 9 male volunteers, each with a long history of illicit IV cocaine (I) use, received separate intravenous doses of I 4-32 mg and dextroamphetamine sulfate (II), 10 mg. The cardiovascular effects of 10 mg II had an effect comparable to 8-16 mg I. The mean heart rate averaged 74 beats per min prior to either drug. It increased to 100 beats/min after 16 mg of I and 112 beats/min after 32 mg of the drug. A 10 and 15% rise in systolic blood pressure occurred with the increases in dosages. Behavior data was also collected during the study.
KW - Cocaine--comparison, dextroamphetamine-;
KW - Dextroamphetamine--comparison, cocaine-;
KW - Central nervous system stimulants--cocaine, comparison, dextroamphetamine--injections, IV, physical and psychological effects, dosage, humans;
KW - Central nervous system stimulants--dextroamphetamine, comparison, cocaine--injections, IV, physical and psychological effects, dosage, humans;
KW - Injections--cocaine, comparison, dextroamphetamine--intravenous, physical and psychological effects, dosage, humans;
KW - Injections--dextroamphetamine, comparison, cocaine--intravenous, physical and psychological effects, dosage, humans;
KW - Dosage--cocaine, comparison, dextroamphetamine--injections, IV, physical and psychological effects, humans;
KW - Dosage--dextroamphetamine, comparison, cocaine--injections, IV, physical and psychological effects, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schneider, Edward L.
T1 - HUMAN AGING.
JO - BioScience
JF - BioScience
Y1 - 1976/08//
VL - 26
IS - 8
M3 - Book Review
SP - 507
EP - 507
SN - 00063568
AB - The article reviews the book "The Physiology and Pathology of Human Aging," edited by Ralph Goldman and Morris Rockstein.
KW - Aging
KW - Nonfiction
KW - Goldman, Ralph
KW - Rockstein, Morris
KW - Physiology & Pathology of Human Aging, The (Book)
N1 - Accession Number: 28049555; Schneider, Edward L. 1; Affiliations: 1 : Laboratory of Cellular & Comparative Physiology Gerontology Research Center, NIH National Institute on Aging HEW Public Health Service Bethesda & Baltimore City Hospitals Baltimore, MD 21224; Source Info: Aug1976, Vol. 26 Issue 8, p507; Subject Term: Aging; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 308
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
TY - GEN
AU - McClane, T. R.;
AU - Martin, W. R.;
T1 - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
CT - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1976/08/01/
VL - 20
IS - Aug
SP - 192
EP - 198
SN - 00099236
AD - National Institute on Drug Abuse, Div. of Research, Addiction Research Center, U.S. Dept. of HEW Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, P.O. Box 12390, Lexington, Kentucky 40511
N1 - Accession Number: 14-2346; Language: English; Chemical Name: Morphine--57-27-2 Meprobamate--57-53-4 Pentobarbital--76-74-4; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers meprobamate, comparison, morphine, pentobarbital (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, meprobamate, pentobarbital; References: 6; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - Pentobarbital (I), morphine (II), and meprobamate (III) were studied in a group of 12 postaddict subjects to determine their effects on subjective states and postrotational nystagmus. I, 150 mg induced a degree of liking and an elevation of the morphine-benzedrine group (MBG) scale score equivalent to 24 mg of II. The effects of I and III on postrotational nystagmus were studied using electro-oculography. Both drugs increased the frequency and prolonged the duration of postrotational nystagmus in a dose related manner. III was about 1/15 as potent as I in enhancing postrotational nystagmus and producing signs of sedation.
KW - Morphine--comparison, meprobamate, pentobarbital-;
KW - Meprobamate--comparison, morphine, pentobarbital-;
KW - Pentobarbital--comparison, meprobamate, morphine-;
KW - Dosage--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW - Dosage--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW - Dosage--pentobarbital, comparison, meprobamate, morphine--effects, subjective, and postrotational nystagmus, humans;
KW - Tranquilizers--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
KW - Analgesics and antipyretics--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Amacher, Richard H
AU - Schneider, John H
T1 - Cancerline: a new nlm/nci data base
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1976/08//
VL - 16
IS - 3
M3 - Article
SP - 128
EP - 130
SN - 00952338
AB - This paper describes collaborative efforts between the national cancer institute (nci) and the national library of medicine (nlm) for the development of a new data base called cancerline. The scope, content, and future enhancements of this on-line file are discussed, as well as the plans for its use to disseminate cancer-related information via nlm's biomedical communications network.
N1 - Accession Number: ISTA1103509; Amacher, Richard H 1; Schneider, John H; Affiliations: 1 : Office Of International Affairs, National Cancer Institute, National Institutes Of Health, Bethesda, Maryland; Source Info: August 1976, Vol. 16 Issue 3, p128; Note: Update Code: 1100; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Feldmann, Richard J
T1 - An international mass spectral search system (msss). v. a status report
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1976/08//
VL - 16
IS - 3
M3 - Article
SP - 176
EP - 178
SN - 00952338
AB - The status of msss is described. Problems and experiences that have been encountered in three years of commerical operation of this system are reported and discussed.
N1 - Accession Number: ISTA1103583; Feldmann, Richard J 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland; Source Info: August 1976, Vol. 16 Issue 3, p176; Note: Update Code: 1100; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Stephens, Richard C.
AU - Levine, Stephen
AU - Ross, Wesley
T1 - STREET ADDICT VALUES: A FACTOR ANALYTIC STUDY.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1976/08//
VL - 99
IS - 2
M3 - Article
SP - 273
PB - Taylor & Francis Ltd
SN - 00224545
N1 - Accession Number: 5391352; Stephens, Richard C. 1,2 Levine, Stephen 1,2 Ross, Wesley 1,2; Affiliation: 1: New York State Drug Abuse Control Commission, New York. 2: National Institute of Mental Health Clinical Research Center, Lexington, Kentucky.; Source Info: Aug1976, Vol. 99 Issue 2, p273; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Johnson, R. E.;
AU - Brereton, H. D.;
AU - Kent, C. H.;
T1 - Small cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure
CT - Small cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/08/07/
VL - 2
IS - Aug 7
SP - 289
EP - 291
SN - 00237507
AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 13-6444; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Doxorubicin--23214-92-8 Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents vincristine; References: 5; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A regimen of intensive, cyclic chemotherapy (cyclophosphamide, vincristine, doxorubicin administered concurrently with radiotherapy) of bulk disease plus prophylactic whole brain irradiation was investigated for small cell carcinoma of the lung in 12 patients. Chemotherapy consisted of cyclic IV administration of doxorubicin (40 mg/sq m), vincristine (2 mg), and cyclophosphamide with all 3 drugs being given on the same day. The dose of cyclophosphamide was 600-1,200 mg/sq m for the first 4 cases and 1,500 mg/sq m in the remaining 17 cases. Chemotherapy was begun on the first day of treatment and cycles were repeated thereafter as soon as the total white blood cell count exceeded 3,500 cells/cu mm. The maximum number of drug cycles was 5 (mean of 4.7 actually given to the 21 patients) and the mean interval between cycles was 20.5 ( 3.7) days. Only 2 patients had a delay of longer than 28 days between any 2 cycles of their chemotherapy. Treatment was completed in 12 weeks, after which patients were observed without maintenance therapy. Complete clinical remissions were noted in 20 of 21 patients with unresectable tumors, 10 of whom had distant extrathoracic spread upon admission. Survival was prolonged and 9 of the 11 patients with regional disease (mediastinal adenopathy with or without pleural effusion and/or supraclavicular nodes) have remained clinically disease free for 6-14 months (median 10) and have resumed normal activities.
KW - Cyclophosphamide--doxorubicin and vincristine-;
KW - Doxorubicin--cyclophosphamide and vincristine-;
KW - Vincristine--cyclophosphamide and doxorubicin-;
KW - Antineoplastic agents--cyclophosphamide--combined therapy, small cell lung carcinoma, patients;
KW - Antineoplastic agents--doxorubicin--combined therapy, small cell lung carcinoma, patients;
KW - Antineoplastic agents--vincristine--combined therapy, small cell lung carcinoma, patients;
KW - Combined therapy--antineoplastic agents--carcinomas, small cell lung, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - WEINSTEIN, I. BERNARD
AU - JEFFREY, ALAN M.
AU - JENNETTE, KAREN W.
AU - BLOBSTEIN, STEVEN H.
AU - HARVEY, RONALD G.
AU - HARRIS, CURTIS
AU - AUTRUP, HERMAN
AU - KASAI, HIROSHI
AU - NAKANISHI, KOJI
T1 - Benzo[a]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in vitro and in vivo.
JO - Science
JF - Science
Y1 - 1976/08/13/
VL - 193
IS - 4253
M3 - Article
SP - 592
EP - 595
SN - 00368075
AB - Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo[a]pyrene, (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[aJpyrene, is an intermediate in the binding of benzo[a]pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85220077; WEINSTEIN, I. BERNARD 1; JEFFREY, ALAN M. 1; JENNETTE, KAREN W. 1; BLOBSTEIN, STEVEN H. 1; HARVEY, RONALD G. 2; HARRIS, CURTIS 3; AUTRUP, HERMAN 3; KASAI, HIROSHI 4; NAKANISHI, KOJI 4; Affiliations: 1: Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York 10032; 2: Ben May Laboratory, University of Chicago, Chicago, Illinois 60637; 3: Human Tissue Studies Section, Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014; 4: Chemistry Department, Columbia University, New York 10027; Issue Info: 8/13/1976, Vol. 193 Issue 4253, p592; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BACHUR, NICHOLAS R.
T1 - Cytoplasmic Aldo-Keto Reductases: A Class of Drug Metabolizing Enzymes.
JO - Science
JF - Science
Y1 - 1976/08/13/
VL - 193
IS - 4253
M3 - Article
SP - 595
EP - 597
SN - 00368075
AB - Aldehyde and ketone xenobiotic substances are preferentially reduced to alcohols by cytoplasmic enzymes in mammals. These enzymes are widely distributed in the tissues, have broad substrate specificities, have similar physical-chemical characteristics, and require reduced nicotinamide adenine dinucleotide as cofactor for the reductions. These reductases define a system of detoxification for aldehyde and ketone groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85220078; BACHUR, NICHOLAS R. 1; Affiliations: 1: Laboratory of Clinical Biochemistry, Baltimore Cancer Research Center, National Cancer Institute, 3100 Wyman Park Drive, Baltimore, Maryland 21211; Issue Info: 8/13/1976, Vol. 193 Issue 4253, p595; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hoover, R.;
AU - Gray, L. A.;
AU - Cole, P.;
AU - MacMahon, B.;
T1 - Menopausal estrogens and breast cancer
CT - Menopausal estrogens and breast cancer
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/08/19/
VL - 295
IS - Aug 19
SP - 401
EP - 405
SN - 00284793
AD - Environmental Epidemiology Branch, National Cancer Institute, Rm. C525, Landow Bldg., Bethesda, Maryland 20014
N1 - Accession Number: 13-6065; Language: English; References: 33; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations
N2 - A total of 1,891 women given conjugated estrogens for the menopause were followed for 12 yr (mean) for incidence of breast cancer. Overall, 49 cases were observed; 39.1 were expected on the basis of rates in the general population (relative risk = 1.3, P = 0.06). The relative risk increased with follow-up duration, progressing to 2.0 after 15 yr (13/6.6, P = 0.01). The excess risk after 10 yr was not due simply to prolonged estrogen use, since there was no clear dose-response relation to accumulated yr of use. However, higher risk accrued to women using higher-dose tablets and those taking the medication on an other than daily basis. In addition, after 10 yr of follow-up observation, 2 factors related to low risk of breast cancer, multiparity and oophorectomy, were no longer so related. Finally, estrogen used was related to an especially high risk of breast cancer among women in whom benign disease developed after they had started the drug.
KW - Estrogenic substances--conjugated--toxicity, studies, breast cancer, patients;
KW - Toxicity--estrogenic substances--conjugated, studies, breast cancer, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - KEBABIAN, JOHN W.
AU - SAAVEDRA, JUAN M.
T1 - Dopamine-Sensitive Adenylate Cyclase Occurs in a Region of Substantia Nigra Containing Dopaminergic Dendrites.
JO - Science
JF - Science
Y1 - 1976/08/20/
VL - 193
IS - 4254
M3 - Article
SP - 683
EP - 685
SN - 00368075
AB - The zona reticulata, the subdivision of the substantia nigra containing dendrites of the dopaminergic nigro-neostriatal neurons, contains dopamine-sensitive adenylate cyclase activity. This nigral dopamine receptor is similar to the striatal dopamine receptor. These and previous data suggest a physiological role (or roles) for dopamine in the substantia nigra. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85220110; KEBABIAN, JOHN W. 1; SAAVEDRA, JUAN M. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 8/20/1976, Vol. 193 Issue 4254, p683; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KUROSAWA, A.
AU - GUIDOTTI, A.
AU - COSTA, E.
T1 - Induction of Tyrosine 3-Monooxygenase in Adrenal Medulla: Role of Protein Kinase Activation and Translocation.
JO - Science
JF - Science
Y1 - 1976/08/20/
VL - 193
IS - 4254
M3 - Article
SP - 691
EP - 693
SN - 00368075
AB - The transsynaptic induction of tyrosine 3-monooxygenase (TH) in rat adrenal medulla is preceded by an early increase in the ratio of cyclic adenosine monophosphate (AMP) to cyclic guanosine monophosphate, an activation of cytosol cyclic AMP-dependent protein kinase, and a subsequent translocation of protein kinase catalytic subunits from cytosol to subcellular particles. As a result of this translocation, nuclear protein kinase activity increases during the induction of TH. Transection of splanchnic nerve reverts these events and prevents the induction of TH. Thus, adrenal medulla activation and translocation of cyclic AMP-dependent protein kinase may act as a long-range messenger for the genetic regulation of TH synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85220114; KUROSAWA, A. 1; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/20/1976, Vol. 193 Issue 4254, p691; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brady, Roscoe O.
T1 - Inherited Metabolic Diseases of the Nervous System.
JO - Science
JF - Science
Y1 - 1976/08/27/
VL - 193
IS - 4255
M3 - Article
SP - 733
EP - 739
SN - 00368075
N1 - Accession Number: 85217928; Brady, Roscoe O. 1; Affiliations: 1: Chief of Developmental and Metabolic Neurology Branch of National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/27/1976, Vol. 193 Issue 4255, p733; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SALZMAN, NORMAN P.
T1 - Regulation of Viruses.
JO - Science
JF - Science
Y1 - 1976/08/27/
VL - 193
IS - 4255
M3 - Article
SP - 756
EP - 756
SN - 00368075
N1 - Accession Number: 85217940; SALZMAN, NORMAN P. 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; Issue Info: 8/27/1976, Vol. 193 Issue 4255, p756; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Minichiello, Lee
AU - Retka, Robert
T1 - Trends in Intravenous Drug Abuse as Reflected in National Hepatitis Reporting.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/09//
VL - 66
IS - 9
M3 - Article
SP - 872
EP - 877
PB - American Public Health Association
SN - 00900036
AB - A procedure for obtaining an indicator of trends in illicit intravenous (I.V.) drug use-a form of drug use which is very harmful and difficult to measure-has been developed using national hepatitis surveillance data. Hepatitis reports are separated into two groups: one containing mostly cases related to transmission via I.V. drug use and the other containing cases related to transmission via personal contact and blood transfusion. The analysis of ten years of national hepatitis reporting (1966 to 1975) shows an almost ten-fold rise in drug-related hepatitis cases from 1966 to 1972. In the last three years the number of cases has declined but remains substantially greater than the pre-epidemic levels. The rise in I.V. drug-related cases began in the 1960's among minority groups living in the center cities of the East and West Coasts and spread during the 1970's into the suburbs of these cities and into metropolitan areas throughout the United States. Limitations of this indicator of I.V. drug use relate to the characteristics of the surveillance system and to the underlying relationship of hepatitis to I.V. drug use. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAVENOUS therapy
KW - PARENTERAL therapy
KW - DRUG abuse
KW - SUBSTANCE abuse
KW - BLOOD transfusion
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 5701861; Minichiello, Lee 1 Retka, Robert 2; Affiliation: 1: Science and Technology Division, Institute for Defense Analyses, 400 Army-Navy Drive, Arlington, VA 22202 2: Division of Resource Development, National Institute on Drug Abuse, Rockville, MD; Source Info: Sep76, Vol. 66 Issue 9, p872; Subject Term: INTRAVENOUS therapy; Subject Term: PARENTERAL therapy; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: BLOOD transfusion; Subject Term: HEPATITIS; Subject Term: COMMUNICABLE diseases; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Schiffer, C.;
AU - Weinstein, H.;
AU - Wiernik, P. H.;
T1 - Methicillin associated thrombocytopenia
CT - Methicillin associated thrombocytopenia
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/09/01/
VL - 85
IS - Sep
SP - 338
EP - 339
SN - 00034819
AD - Section of Medical Oncology, National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
N1 - Accession Number: 14-1916; Language: English; Chemical Name: Methicillin--61-32-5; References: 5; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Gail Marie Pezzullo
N2 - A case study of a 41-yr-old woman with acute lymphoblastic leukemia is presented to illustrate thrombocytopenia induced by administration of methicillin (I) 4 g IV every 6 hr. Shortly following chemotherapy with vincristine, dexamethasone, thioguanine and pyrimethamine the patient became febrile, developed oral cellulitis and was treated with carbenicillin and gentamicin. Results of blood cultures revealed \IT/S. aureus\OK/ and antibiotic treatment was changed to I. The infection improved but the patient became thrombocytopenic, unresponsive to multiple platelet transfusions. Upon discontinuation of I and the initiation of cephalothin 3 g IV every 6 hr, the patient's platelet count rose profoundly. Development of phlebitis rendered discontinuation of cephalothin and restarting I. This immediately led to a dramatic fall in platelet count and was again discontinued. Tests for antiplatelet antibody were done using serum obtained throughout the patient's course of treatment and appropriate control sera. Antibody detectable in vitro was noted only in the presence of I and only in the patient's platelet rich plasma and in platelet rich plasma of a normal patient receiving oral cloxacillin. Drug dependent antiplatelet antibody was documented both in vitro and by reexposure in vivo in this patient. No other similar cases have been reported.
KW - Methicillin--adverse reactions-;
KW - Drugs, adverse reactions--methicillin--thrombocytopenia, acute lymphoblastic leukemia patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Berard, C.;
AU - Gallo, R.;
AU - Jaffe, E.;
AU - Green, I.;
AU - DeVita, V. T.;
T1 - Current concepts of leukemia and lymphoma: etiology, pathogenesis and therapy
CT - Current concepts of leukemia and lymphoma: etiology, pathogenesis and therapy
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/09/01/
VL - 85
IS - Sep
SP - 351
EP - 366
SN - 00034819
AD - Lab. of Pathology, National Cancer Institute, Building 10, Room 2A-09, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-2065; Language: English; References: 125; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Gail Marie Pezzullo
N2 - The origin of leukemia, especially acute myelogenous leukemia, and its therapy is presented. Evidence for type-C virus components in human leukemia and the effect of these findings on our understanding of the pathogenesis and pathophysiology of these disorders is discussed. A summary of present knowledge regarding immunologic markers on the cells of these tumors is reported. Trends in the treatment of acute lymphocytic leukemia of childhood, acute myelogenous leukemia, Hodgkin's disease and diffuse histocyte lymphoma are elaborated upon.
KW - Antineoplastic agents--combined therapy--leukemias, Hodgkin's disease, and lymphomas, disease etiology and current concepts, review;
KW - Combined therapy--antineoplastic agents--leukemias, Hodgkin's disease, and lymphomas, disease etiology and current concepts, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Adler, William H.
T1 - THYMIC HORMONES.
JO - BioScience
JF - BioScience
Y1 - 1976/09//
VL - 26
IS - 9
M3 - Book Review
SP - 569
EP - 569
SN - 00063568
AB - The article reviews the book "The Biological Activity of Thymic Hormones," edited by D. W. Van Bekkum.
KW - Thymic hormones
KW - Nonfiction
KW - Van Bekkum, D. W.
KW - Biological Activity of Thymic Hormones, The (Book)
N1 - Accession Number: 28049775; Adler, William H. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224; Source Info: Sep1976, Vol. 26 Issue 9, p569; Subject Term: Thymic hormones; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 435
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Coe, J.E.
AU - Leong, D.
AU - Portis, J.L.
AU - Thomas, L.A.
T1 - Immune response in the garter snake (Thamnophis ordinoides).
JO - Immunology
JF - Immunology
Y1 - 1976/09//
VL - 31
IS - 3
M3 - Article
SP - 417
EP - 424
PB - Wiley-Blackwell
SN - 00192805
AB - Garter snakes (Thamnophis ordinoides) were immunized with hen egg albumin, human gamma-globulin and Keyhole limpet haemocyanin in Freund's adjuvant. Antibody was consistently detected by radioimmunoelectrophoresis and in three different γ- and β-globulin precipitin lines called Ig-M (...20S), Ig-I (...9S) and Ig-2 (....8.5S). Early antibody (day 31 after immunization) was frequently Ig-M whereas Ig-2 and especially Ig-1 were detectable for the longest duration (992 days). After immunization with antigen in Freund's adjuvant, Ig-I serum concentration showed the greatest increase, from almost undetectable levels to the most prominent immunoglobulin in immune serum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GARTER snakes
KW - IMMUNOLOGICAL adjuvants
KW - IMMUNIZATION
KW - ALBUMINS
KW - GAMMA globulins
KW - HEMOCYANIN
KW - IMMUNOGLOBULINS
N1 - Accession Number: 13372762; Coe, J.E. 1 Leong, D. 1 Portis, J.L. 1 Thomas, L.A. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Sep76, Vol. 31 Issue 3, p417; Subject Term: GARTER snakes; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: IMMUNIZATION; Subject Term: ALBUMINS; Subject Term: GAMMA globulins; Subject Term: HEMOCYANIN; Subject Term: IMMUNOGLOBULINS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shinohara, N.
AU - Okumura, K.
AU - Kern, M.
T1 - Differentiation of lymphoid cells: the non-mitogenic induction of immunoglobulin production by thymus cell extract and thymus cell culture filtrate.
JO - Immunology
JF - Immunology
Y1 - 1976/09//
VL - 31
IS - 3
M3 - Article
SP - 433
EP - 441
PB - Wiley-Blackwell
SN - 00192805
AB - The cell-free medium in which thymocytes have been cultured (filtrate) as well as sonic lysates of thymocytes (extract) enhance immunoglobulin production when added to spleen cells during tissue culture. In spite of the requirement for foetal calf serum in the culture medium, production of the enhancing factor in thymocyte culture filtrates occurred even in the presence of a variety of metabolic inhibitors including NaN3, puromycin and hydroxyurea. Although DNA synthesis is required as a prelude to the induction of immunoglobulin production, two lines of evidence indicate that the enhancement produced in response to filtrate and extract occurs via a non-mitogenic process. First, neither cell-free agent was mitogenic toward spleen cells. Secondly, the enhancement of immunoglobulin production due to filtrate or extract was observed even in the presence of inhibitors of DNA synthesis. Multiple functions for thymocytes in the induction of immunoglobulin production are indicated by the findings that thymocytes restore immunoglobulin production of anti-thymocyte serum-treated spleen cells, whereas filtrate and extract, alone or in combination, do not have this capability. Furthermore, filtrate and extract failed to enhance the induction of DNP-group-specific antibody production by cells incubated with DNP-protein, but filtrate and extract could partially restore anti-DNP antibody pro- diction of such anti-thymocyte serum-treated cells. The role of thymocytes, filtrate and extract in the antigen-independent and the antigen-dependent induction of immunoglobulin production is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - IMMUNOGLOBULINS
KW - SPLEEN
KW - CELL culture
KW - THYMUS extract
KW - IMMUNOLOGY
N1 - Accession Number: 13372911; Shinohara, N. 1 Okumura, K. 1 Kern, M. 1; Affiliation: 1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA; Source Info: Sep76, Vol. 31 Issue 3, p433; Subject Term: LYMPHOID tissue; Subject Term: IMMUNOGLOBULINS; Subject Term: SPLEEN; Subject Term: CELL culture; Subject Term: THYMUS extract; Subject Term: IMMUNOLOGY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J. E.
T1 - Immunoglobulin synthesis by an SV-40-induced hamster lymphoma.
JO - Immunology
JF - Immunology
Y1 - 1976/09//
VL - 31
IS - 3
M3 - Article
SP - 495
EP - 502
PB - Wiley-Blackwell
SN - 00192805
AB - A transplantable lymphoid tumour induced in Syrian hamsters by SV-40 was shown to synthesize a 7Sγ2 monoclonal immunoglobulin which was detectable in the serum of tumour-bearing hamsters. Monoclonal immunoglobulin of the same idiotype was also found in the membrane of the tumour cell. The induction of immunoglobulin synthesizing turnouts by SV-40 should be useful for studies on immunoglobulin synthesis, lymphoid cell receptors and tumour immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOMAS
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - IMMUNE serums
KW - CANCER cells
KW - CELL membranes
N1 - Accession Number: 13373005; Coe, J. E. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Sep76, Vol. 31 Issue 3, p495; Subject Term: LYMPHOMAS; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNE serums; Subject Term: CANCER cells; Subject Term: CELL membranes; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J. E.
T1 - Immunoglobulin synthesis by an SV-40-induced hamster lymphoma.
JO - Immunology
JF - Immunology
Y1 - 1976/09//
VL - 31
IS - 3
M3 - Article
SP - 495
EP - 502
SN - 00192805
AB - A transplantable lymphoid tumour induced in Syrian hamsters by SV-40 was shown to synthesize a 7Sγ2 monoclonal immunoglobulin which was detectable in the serum of tumour-bearing hamsters. Monoclonal immunoglobulin of the same idiotype was also found in the membrane of the tumour cell. The induction of immunoglobulin synthesizing turnouts by SV-40 should be useful for studies on immunoglobulin synthesis, lymphoid cell receptors and tumour immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOMAS
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - IMMUNE serums
KW - CANCER cells
KW - CELL membranes
N1 - Accession Number: 13373005; Coe, J. E. 1; Source Information: Sep76, Vol. 31 Issue 3, p495; Subject: LYMPHOMAS; Subject: MONOCLONAL antibodies; Subject: IMMUNOGLOBULINS; Subject: IMMUNE serums; Subject: CANCER cells; Subject: CELL membranes; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Kaplan, Allen P.
AU - Beaven, Michael A.
T1 - IN VIVO STUDIES OF THE PATHOGENESIS OF COLD URTICARIA, CHOLINERGIC URTICARIA, AND VIBRATION-INDUCED SWELLING.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/09//
VL - 67
IS - 3
M3 - Article
SP - 327
EP - 332
SN - 0022202X
AB - The disorders generally classified as physical urticarias include cold urticaria, local and generalized heat urticaria, dermographism, pressure urticaria and vibration-induced angioedema. Cold urticaria is characterized by the rapid development of hives and swelling after exposure to a cold stimulus. It can occur in any age group, has no predilection for either sex and is not associated with other allergic disorders. Cholinergic urticaria or generalized heat urticaria is induced by an increase in body temperature associated with exposure to a hot stimulus or as a consequence of exercise or psychic stimuli.
KW - URTICARIA
KW - SKIN -- Inflammation
KW - ANGIONEUROTIC edema
KW - ALLERGY
KW - EDEMA
KW - CHOLINERGIC mechanisms
N1 - Accession Number: 12514352; Kaplan, Allen P. 1,2 Beaven, Michael A. 1,2; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy, Bethesda, Maryland, U. S. A. 2: Infectious Diseases, and Pulmonary Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Sep76, Vol. 67 Issue 3, p327; Subject Term: URTICARIA; Subject Term: SKIN -- Inflammation; Subject Term: ANGIONEUROTIC edema; Subject Term: ALLERGY; Subject Term: EDEMA; Subject Term: CHOLINERGIC mechanisms; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12514352
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirkpatrick, Charles H.
AU - Smith, Terrill K.
T1 - THE NATURE OF TRANSFER FACTOR AND ITS CLINICAL EFFICACY IN THE MANAGEMENT OF CUTANEOUS DISORDERS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/09//
VL - 67
IS - 3
M3 - Article
SP - 425
EP - 430
SN - 0022202X
AB - It was reported that delayed hypersensitivity could be transferred with lymphoid cells from reactive human donors to previously unresponsive recipients. In the experiments transfer factor (TF) has been prepared from peripheral blood leukocytes collected with a continuous-flow blood cell separator or a Latham Blood Processor. The protocol for preparing the TF varies slightly depending upon the plans for the preparation. In some cases whole cell suspensions including leukocytes, erythrocytes and platelets are disrupted by repeated freezing and thawing.
KW - DELAYED hypersensitivity
KW - TRANSFER factor (Immunology)
KW - LYMPHOKINES
KW - LEUCOCYTES
KW - BLOOD platelets
KW - ERYTHROCYTES
N1 - Accession Number: 12514723; Kirkpatrick, Charles H. 1,2 Smith, Terrill K. 1,2; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy, Bethesda, Maryland, U. S. A. 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Sep76, Vol. 67 Issue 3, p425; Subject Term: DELAYED hypersensitivity; Subject Term: TRANSFER factor (Immunology); Subject Term: LYMPHOKINES; Subject Term: LEUCOCYTES; Subject Term: BLOOD platelets; Subject Term: ERYTHROCYTES; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12514723
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wooster, Harold
T1 - An Experiment in Networking: The LHNCBC Experimental CAI Network, 1971-1975.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1976/09//Sep-Oct1976
VL - 27
IS - 5/6
M3 - Article
SP - 329
EP - 338
SN - 00028231
AB - This is an administrative history of an information network. In somewhat less than four years, the Lister Hill National Center for Biomedical Communications of the National Library of Medicine built this network, demonstrated a substantial demand for its services, encouraged it to become self-sustaining, and transferred support and operation to a user consortium. The paper is concerned with the process, and some of the problems, of innovation rather than the product, biomedical computer- assisted instruction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFORMATION networks
KW - INFORMATION science
KW - LIBRARIES
KW - COMPUTER assisted instruction
KW - ACADEMIC libraries
KW - MEDICINE
N1 - Accession Number: 16747705; Wooster, Harold 1; Affiliations: 1: Lister Hill National Center for Biomedical Communications National Library of Medicine National Institutes of Health Bethesda, MD 20014.; Issue Info: Sep-Oct1976, Vol. 27 Issue 5/6, p329; Thesaurus Term: INFORMATION networks; Thesaurus Term: INFORMATION science; Thesaurus Term: LIBRARIES; Subject Term: COMPUTER assisted instruction; Subject Term: ACADEMIC libraries; Subject Term: MEDICINE; NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519121 Libraries; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gail, Mitchell H.
AU - Green, Sylvan B.
T1 - Critical Values for the One-Sided Two-Sample Kolmogorov-Smirnov Statistic.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1976/09//
VL - 71
IS - 355
M3 - Article
SP - 757
SN - 01621459
AB - We present a new recursion for counting the number of paths which ever attain a given height. Using this recursion, we calculate exact critical values for the one-sided two-sample Kolmogorov-Smirnov statistic for n and m = 3(1)30 and for significance levels alpha = 0.10, 0.05 and 0.01. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICS
KW - MULTIVARIATE analysis
KW - ONE (The number)
KW - RECURSION theory
KW - PATH analysis (Statistics)
KW - KOLMOGOROV complexity
KW - ALTITUDES
N1 - Accession Number: 4607807; Gail, Mitchell H. 1; Green, Sylvan B. 2; Affiliations: 1: Medical Statistical Researcher, National Cancer Institute, Landow Building C-509, Bethesda, MD 20014.; 2: Medical Researcher, National Cancer Institute, Landow Building C-509, Bethesda, MD 20014.; Issue Info: Sep76, Vol. 71 Issue 355, p757; Thesaurus Term: STATISTICS; Thesaurus Term: MULTIVARIATE analysis; Subject Term: ONE (The number); Subject Term: RECURSION theory; Subject Term: PATH analysis (Statistics); Subject Term: KOLMOGOROV complexity; Subject Term: ALTITUDES; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Robinson, R. A.;
AU - DeVita, V. T.;
AU - Levy, H. B.;
AU - Baron, S.;
AU - Hubbard, S. P.;
AU - \ET/;
T1 - Phase I-II trial of multiple-dose polyriboinosinic-polyribocytidylic acid in patients with leukemia or solid tumors
CT - Phase I-II trial of multiple-dose polyriboinosinic-polyribocytidylic acid in patients with leukemia or solid tumors
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1976/09/01/
VL - 57
IS - Sep
SP - 599
EP - 602
SN - 00278874
AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 14-1318; Language: English; Trade Name: Poly I: Poly C; Generic Name: Polyinosinic-polycytidylic acid; Chemical Name: Polyinosinic-polycytidylic acid--24939-03-5; References: 21; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Polyinosinic-polycytidylic acid (I; Poly I: Poly C), was administered in multiple doses of 0.3-75 mg/sq m to 26 patients with a variety of solid tumors, 9 with acute leukemia, and 2 with chronic myelogenous leukemia in blast crisis. Forty-four separate drug trials were comprised of various schedules and routes of administration. Toxic reactions included fever (in 66% of the trials), transient elevation of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase (25%), minimal laboratory evidence of coagulation abnormalities (59%), and hypersensitivity (5%). These toxic manifestations did not relate to dose level or magnitude of interferon induction. I administered IV induced low serum concentrations of interferon in 24/38 trials (63%), but the correlation between drug dose and peak interferon titer was not linear. I administered IV or IM was not effective as an inducer of interferon in the cerebrospinal fluid. Similarly, I administered IM or by inhalation did not produce detectable serum levels of interferon. No patients experienced an objective tumor response to the administration of I, and most (76%) had progression of their disease while receiving the drug.
KW - Polyinosinic-polycytidylic acid--effects-;
KW - Interferon inducers--polyinosinic-polycytidylic acid--lack, effects, and tumor regression, cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Bhat, M Ishwara
T1 - Sources and channels of pre-investment information: requirments of small scale industries
JO - Library Science with a Slant to Documentation
JF - Library Science with a Slant to Documentation
Y1 - 1976/09//September-December 1976
VL - 13
IS - 3-4
M3 - Article
SP - 113
EP - 120
SN - 00242543
AB - Presents a short report of a pilot study carried out to identify the pre-investment information requirements, and the sources and channels used by small entrepreneurs, and also that usage of different information sources. The data were collected by direct and indirect methods, by interviews with potential entrepreneurs, new enterpreneurs, established entrepreneurs, financing agencies and small industry promotion institutes. Comments on the findings of the study. Conclusions and recommendations are made.
N1 - Accession Number: ISTA1303839; Bhat, M Ishwara 1; Affiliations: 1 : National Institute Of Mental Health And Neurosciences, Bangalore; Source Info: September-December 1976, Vol. 13 Issue 3-4, p113; Note: Update Code: 1300; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - NELSON, S. D.
AU - MITCHELL, J. R.
AU - TIMBRELL, J. A.
AU - SNODGRASS, W. R.
AU - CORCORAN III, G. B.
T1 - Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat.
JO - Science
JF - Science
Y1 - 1976/09/03/
VL - 193
IS - 4256
M3 - Article
SP - 901
EP - 903
SN - 00368075
AB - Acetylhydrazine, a metabolite of isoniazid, a widely used antituberculosis drug, and isopropylhydrazine, a metabolite of iproniazid, an antidepressant removed from clinical use because of high incidence of liver injury, were oxidized by cytochrome P450 enzymes in human and rat liver microsomes to highly reactive acylating and alkylating agents. Covalent binding of these metabolites to liver macromolecules paralleled hepatic cellular necrosis. The metabolites formed from these andprobably other monosubstituted hydrazines are reactive electrophiles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003135; NELSON, S. D. 1; MITCHELL, J. R. 1; TIMBRELL, J. A. 1; SNODGRASS, W. R. 1; CORCORAN III, G. B. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/ 3/1976, Vol. 193 Issue 4256, p901; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Adams, E.;
AU - Decker, D. G.;
AU - Herbst, A. L.;
AU - Noller, K. L.;
AU - Tilley, B. C.;
AU - \ET/;
T1 - Exposure in utero to diethylstilbestrol and related synthetic hormones: association with vaginal and cervical cancers and other abnormalities
CT - Exposure in utero to diethylstilbestrol and related synthetic hormones: association with vaginal and cervical cancers and other abnormalities
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/09/06/
VL - 236
IS - Sep 6
SP - 1107
EP - 1109
AD - Van Nevel, J. P., Office of Cancer Communications, National Cancer Institute, N.I.H., Bethesda, Maryland 20014
N1 - Accession Number: 14-0044; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Publication Type: Professional and Public Relations Committee of the DESAD (Diethylstilbestrol and Adenosis) Project of the Division of Cancer Control and Rehabilitation; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - The National Cancer Institute supported study of vaginal cancer and other noncancerous genital tract irregularities in offspring of mothers who received synthetic estrogens (including diethylstilbestrol) during pregnancy is discussed.
KW - Diethylstilbestrol--toxicity-;
KW - Toxicity--diethylstilbestrol--studies, vaginal cancer following exposure in utero, humans;
KW - Estrogens--toxicity--studies, vaginal cancer following exposure in utero, humans;
KW - Toxicity--estrogens--studies, vaginal cancer following exposure in utero, humans;
KW - Placental transfer--diethylstilbestrol--toxicity, studies, vaginal cancer following exposure in utero, humans;
KW - Placental transfer--estrogens--toxicity, studies, vaginal cancer following exposure in utero, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MORGAN, DORIS ANNE
AU - RUSCETTI, FRANCIS W.
AU - GALLO, ROBERT
T1 - Selective in vitro Growth of T Lymphocytes from Normal Human Bone Marrows.
JO - Science
JF - Science
Y1 - 1976/09/10/
VL - 193
IS - 4257
M3 - Article
SP - 1007
EP - 1008
SN - 00368075
AB - Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9 months. The T cells exhibited a strict growth dependence upon Ly-CM and were consistently negative for Epstein-Barr viral information. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85217986; MORGAN, DORIS ANNE 1; RUSCETTI, FRANCIS W. 1; GALLO, ROBERT 2; Affiliations: 1: Litton Bionetics Research Laboratories, Bethesda, Maryland 20014; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/10/1976, Vol. 193 Issue 4257, p1007; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEIGHT, FORREST F.
AU - ERULKAR, S. D.
T1 - Modulation of Synaptic Transmitter Release by Repetitive Postsynaptic Action Potentials.
JO - Science
JF - Science
Y1 - 1976/09/10/
VL - 193
IS - 4257
M3 - Article
SP - 1023
EP - 1025
SN - 00368075
AB - The effect of repetitive action potentials in the postsynaptic axon on therelease of synaptic transmitter from the presynaptic terminal was investigated at the squid giant synapse. Repetitive antidromic stimulation of the postsynaptic axon resulted in a reduction in the excitatory postsynaptic potential (EPSP). The reduction in transmitter release was accompanied by a decrease in the presynaptic spike after hyperpolarization (AH). Increasing the concentration of extracellular potassium ions also reduced the EPSP and decreased the amplitude of the presynaptic spike AH. The reduction in transmitter release resulting from repetitive postsynaptic impulses is attributed to the accumulation of extracellular potassium ions. It is proposed that the accumulation of extracellular potassium ions resulting from repetitive postsynaptic activity may modulate synaptic transmission and function as an integrative mechanism in the nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85217994; WEIGHT, FORREST F. 1; ERULKAR, S. D. 1,2; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19174; Issue Info: 9/10/1976, Vol. 193 Issue 4257, p1023; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - GWADZ, ROBERT W.
T1 - Malaria: Successful Immunization Against the Sexual Stages of Plasmodium gallinaceum.
JO - Science
JF - Science
Y1 - 1976/09/17/
VL - 193
IS - 4258
M3 - Article
SP - 1150
EP - 1151
SN - 00368075
AB - Gametocyte infectivity and oocyst development of the avian malaria parasite, Plasmodium gallinaceum, can be reduced or eliminated in mosquitoes by immunizing the chickens on which the mosquitoes feed with infected red blood cells that have been treated with formalin or x-rays. Protection of the mosquito appears to be related to the immobilization of the microgametes in its gut and is associated with the immunoglobulin G fraction of serum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218038; GWADZ, ROBERT W. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/17/1976, Vol. 193 Issue 4258, p1150; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FREDRICKSON, DONALD S.
T1 - Recombinant DNA Guidelines: Environmental Impact Statement.
JO - Science
JF - Science
Y1 - 1976/09/24/
VL - 193
IS - 4259
M3 - Article
SP - 1196
EP - 1196
SN - 00368075
N1 - Accession Number: 85218043; FREDRICKSON, DONALD S. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland, 20014; Issue Info: 9/24/1976, Vol. 193 Issue 4259, preceding p1196; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Schein, P. S.;
AU - DeVita V. T.;
AU - Hubbard, S.;
AU - Chabner, B. A.;
AU - Canellos, G. P.;
AU - \ET/;
T1 - Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma
CT - Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/10/01/
VL - 85
IS - Oct
SP - 417
EP - 422
SN - 00034819
AD - Reprints: Div. of Medical Oncology, Georgetown Univ. Hospital, Room 2230, 3800 Reservoir Rd., Northwest, Washington, D.C. 20007
AD - Medicine Branch and Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 14-2294; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Cyclophosphamide--6055-19-2 Doxorubicin--23214-92-8 Vincristine--57-22-7 Bleomycin--11056-06-7 Prednisone--53-03-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents bleomycin (10:00); AHFS Class: Antineoplastic agents prednisone; References: 22; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Robert J. Cersosimo
N2 - Thirty-six adult patients with stages II-IV diffuse histiocytic lymphoma or diffuse mixed histiocytic-lymphocytic lymphoma were treated with 6 monthly cycles consisting of a myelosuppressive phase in which 650 mg/sq m of cyclophosphamide, 25 mg/sq m of Adriamycin (doxorubicin), and 1.4 mg/sq m of vincristine were administered IV on days one and 8 and a nonmyelosuppressive phase in which 5-15 u/sq m of IV bleomycin were administered on days 15 and 22 and 60 mg/sq m of oral prednisone were administered on days 15-29. Twenty-five patients were previously untreated, 11 other patients had relapsed after radiation or combination chemotherapy. Patients were re-staged one month after completing therapy. Twelve of the 25 previously untreated patients (48%) achieved complete remission and had not relapsed for 5-30 months after completion of therapy. There were 9 partial remissions and 4 nonresponders in the previously untreated group. Three of 11 previously treated patients achieved complete remission, 2 of whom relapsed within 4 months of completion of therapy. There were 5 partial remissions in the previously treated group. It was concluded that the complete remission rate and expected survival approached that achieved in Hodgkin's disease treated with intensive combination chemotherapy and that larger comparative studies are needed.
KW - Cyclophosphamide--bleomycin, doxorubicin, prednisone and vincristine-;
KW - Doxorubicin--bleomycin, cyclophosphamide, prednisone and vincristine-;
KW - Vincristine--bleomycin, cyclophosphamide, doxorubicin and prednisone-;
KW - Bleomycin--cyclophosphamide, doxorubicin, prednisone and vincristine-;
KW - Prednisone--bleomycin, cyclophosphamide, doxorubicin and vincristine-;
KW - Combined therapy--antineoplastic agents--lymphomas, patients;
KW - Antineoplastic agents--cyclophosphamide--combined therapy, lymphomas, patients;
KW - Antineoplastic agents--doxorubicin--combined therapy, lymphomas, patients;
KW - Antineoplastic agents--vincristine--combined therapy, lymphomas, patients;
KW - Antineoplastic agents--bleomycin--combined therapy, lymphomas, patients;
KW - Antineoplastic agents--prednisone--combined therapy, lymphomas, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Janossy, G.
AU - De La Concha, E. Gomez
AU - Waxdal, M. J.
AU - Platts-Mills, T.
T1 - The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/10//
VL - 26
IS - 1
M3 - Article
SP - 108
EP - 117
PB - Wiley-Blackwell
SN - 00099104
AB - Purified proteins (Pa-1 and Pa-2) from pokeweed have been compared with commercial pokeweed mitogen (PWM-G) and other mitogens in their ability to stimulate human lymphocytes. With cultures of T and B cells separated from tonsil lymphocytes, thymidine uptake, blast transformation and immunnglobulin (Ig) synthesis have been measured. IgM and IgG was measured in supernates of stimulated cultures by radioimmunoassay. Pa-1, Pa-2 and PWM-G were found to be potent mitogens for unseparated tonsil lymphocytes or nylon column purified T cells. Pa-2 was found to be active at lower concentrations than Pa-1. and PWM-G was less potent than the purified mitogens. These three mitogens all stimulated unseparated lymphocytes to secrete large quantities of Ig (20-100μg/ml) during 7 days in culture. With increasing amounts of mitogens severe decreases in immunoglobulin synthesis were observed at day 6 even with doses which were still optimal for stimulation of thymidine uptake at days 3 and 6. With purified B cells (<2% T cells) Pa-1 was the best mitogen for thymidine incorporation. However, the secretory response was very variable. In some experiments H ceils did not secrete Ig in response to mitogens, in others Pa-1 was clearly more; effective at stimulating secretion than Pa-2 or PWM-G and in some experiments B cells were stimulated by all three. In one experiment Pa-1 stimulated prolymphocytic leukaemia cells to blast transformation and the secretion of IgM. It is concluded that Pa-1, Pa-2 anti PWM-G are much better activators of Ig synthesis in human cultures than either PHA or LPS and that Pa-1 is the most reliable B-cell stimulant of the three. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - B cells
KW - BIOLOGICAL transport
KW - IMMUNOGLOBULIN G
KW - LECTINS
N1 - Accession Number: 16017732; Janossy, G. 1 De La Concha, E. Gomez 2 Waxdal, M. J. 3 Platts-Mills, T. 2; Affiliation: 1: Imperial Cancer Research Fund, Tumour Immunology Unit, University College, London. 2: Division of Immunology, Clinical Research Centre, Harrow, Middlesex. 3: National Institute of Arthritis and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct1976, Vol. 26 Issue 1, p108; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: B cells; Subject Term: BIOLOGICAL transport; Subject Term: IMMUNOGLOBULIN G; Subject Term: LECTINS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Lystad, Mary1
T1 - Over 200 Years of American Children's Literature.
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1976/10//
Y1 - 1976/10//
VL - 42
IS - 2
CP - 2
M3 - Article
SP - 36
EP - 39
SN - 0013127X
AB - The article discusses that children's books reflect the attitudes and values of the society. Through children's books one can see the hopes and concerns the U.S. society holds for its young and for its own future. By 1850, soul-saving didacticism was giving way to interest in the family. Around 1920 a strong interest in children as children began to appear in literature for the young. Humanistic concern for the child's own dignity prompted efforts to satisfy his needs and desires. Social problems are now also handled openly in children's literature. Problems of divorce, death, mental retardation, mental illness, senility, race, poverty, crime, drug addiction, and alcoholism are becoming the subjects of novels for young people. In the next century, interest in the child as a being will very likely continue, with interest in individual differences among children increasing as pressure for social change mounts from women and minorities. Such eventualities will be reinforced by child development specialists and by educators, who advocate more meaningful reading fare so children will be inclined to learn to read and to learn to interact with their society.
KW - Children's literature
KW - Reading -- Social aspects
KW - Child development
KW - Humanistic writing
KW - Social problems
KW - Social change
KW - Educators
KW - United States
N1 - Accession Number: 18831038; Authors: Lystad, Mary 1; Affiliations: 1: Special Assistant to the Director, Division of Special Mental Health Programs, National Institute of Mental Health, Rockville, Maryland.; Subject: Children's literature; Subject: Reading -- Social aspects; Subject: Child development; Subject: Humanistic writing; Subject: Social problems; Subject: Social change; Subject: Educators; Subject: United States; Number of Pages: 4p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Sohnle, Peter G.
AU - Kirkpatrick, Charles H.
T1 - Deposition of Complement in the Lesions of Experimental Cutaneous Candidiasis in Guinea Pigs.
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
Y1 - 1976/10//
VL - 3
IS - 5
M3 - Article
SP - 323
EP - 238
SN - 03036987
AB - Deposits of C3 have been demonstrated at the dermo-epidermal junction in the lesions of experimental cutaneous candidiasis in guinea pigs. The deposits were granular in character and similar to those previously found in the lesions of chronic mucocutaneous candidiasis in humans. Immunoglobulin, C4 and candida antigen were not detected in the lesions. C3 was also found in a similar pattern at the dermo-epidermal junction of candida-infected skin from homozygous C4-deficient guinea pigs. From these observations, it is postulated that complement deposition occurs in these lesions as a result of alternative pathway activation, perhaps by cell wall components from the infecting organisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUINEA pigs
KW - CAVIIDAE
KW - CANDIDIASIS
KW - MYCOSES
KW - IMMUNOGLOBULINS
KW - EPIDERMIS
N1 - Accession Number: 11814759; Sohnle, Peter G. 1 Kirkpatrick, Charles H. 1; Affiliation: 1: Laboratory of Clinical Investigation, National institute of Allergy and Infectious Diseases, Bethesda, MD 20014 U.S.A.; Source Info: 1976, Vol. 3 Issue 5, p323; Subject Term: GUINEA pigs; Subject Term: CAVIIDAE; Subject Term: CANDIDIASIS; Subject Term: MYCOSES; Subject Term: IMMUNOGLOBULINS; Subject Term: EPIDERMIS; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0560.ep11814759
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Yaoita, Hideo
AU - Katz, Stephen I.
T1 - IMMUNOELECTRONMICROSCOPIC LOCALIZATION OF IgA IN SKIN OF PATIENTS WITH DERMATITIS HERPETIFORMIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/10//
VL - 67
IS - 4
M3 - Report
SP - 502
EP - 506
SN - 0022202X
AB - Ultrastructural localization of in vivo-bound IgA in the skin of patients with dermatitis herpetiformis was determined by using a modified peroxidase-antiperoxidase multistep method. Three types of reaction product deposition are seen. The most common type of reaction product deposition, that which is identified by direct immunofluorescence as the speckled type of IgA deposit, shows up as clumps and yarnlike fibrils. The second type of IgA deposition, which is a linear band by direct immunofluorescence, appears to be associated with anchoring fibrils. The third type of IgA deposition, which is also linear by immuno- fluorescence, is confined to the lamina lucida. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATITIS herpetiformis
KW - IMMUNOGLOBULIN A
KW - DERMATOLOGY
KW - IMMUNOFLUORESCENCE
KW - IMMUNOGLOBULINS
KW - FLUORESCENCE
KW - IMMUNOLOGY -- Technique
N1 - Accession Number: 12664534; Yaoita, Hideo 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S. A..; Source Info: Oct76, Vol. 67 Issue 4, p502; Subject Term: DERMATITIS herpetiformis; Subject Term: IMMUNOGLOBULIN A; Subject Term: DERMATOLOGY; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNOGLOBULINS; Subject Term: FLUORESCENCE; Subject Term: IMMUNOLOGY -- Technique; Number of Pages: 5p; Document Type: Report
L3 - 10.1111/1523-1747.ep12664534
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Silbergeld, Sam
AU - Koenig, Gail R.
AU - Manderscheid, Ronald W.
T1 - ASSESSMENT OF THE PSYCHOSOCIAL ENVIRONMENT OF THE CLASSROOM: THE CLASS ATMOSPHERE SCALE.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1976/10//
VL - 100
IS - 1
M3 - Article
SP - 65
PB - Taylor & Francis Ltd
SN - 00224545
N1 - Accession Number: 5393754; Silbergeld, Sam 1,2 Koenig, Gail R. 1,2 Manderscheid, Ronald W. 1,2; Affiliation: 1: National Institute of Mental Health, University of Maryland. 2: Department of Sociology, University of Maryland.; Source Info: Oct1976, Vol. 100 Issue 1, p65; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - DeVita, V. T.;
AU - Kershner, L. M.;
T1 - Adjuvant chemotherapy with anticancer drugs
CT - Adjuvant chemotherapy with anticancer drugs
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1976/10/01/
VL - 42
IS - Oct
SP - 58
EP - 63
SN - 00030627
AD - National Cancer Institute, NIH, Bethesda, Maryland
N1 - Accession Number: 14-2061; Language: English; Trade Name: L-Phenylalanine mustard--Cytoxan; Generic Name: Melphalan; Cyclophosphamide; Chemical Name: Melphalan--148-82-3 Cyclophosphamide--6055-19-2 Fluorouracil--51-21-8 Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents melphalan (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents fluorouracil; Journal Coden: PYTMAO; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Walter F. Stanaszek
N2 - The role of anticancer drugs in treatment of solid tumors is discussed as they are currently being employed in adjuvant chemotherapy, i.e., soon after surgery to attack micrometastases undetectable by current diagnostic techniques. Studies are reported in which L-phenylalanine mustard (melphalan) and a combination of Cytoxan (cyclophosphamide), methotrexate and fluorouracil both showed a statistically significant difference as compared to controls in length of disease free interval. Specific regimens for studies in patients with breast cancer and osteogenic sarcoma are outlined, as are criteria for adjuvant chemotherapy trials.
KW - Melphalan--tumors-;
KW - Cyclophosphamide--fluorouracil and methotrexate-;
KW - Fluorouracil--cyclophosphamide and methotrexate-;
KW - Methotrexate--cyclophosphamide and fluorouracil-;
KW - Antineoplastic agents--melphalan--tumors, solid, therapy, discussion;
KW - Antineoplastic agents--cyclophosphamide--combined therapy, solid tumors, discussion;
KW - Antineoplastic agents--methotrexate--combined therapy, solid tumors, discussion;
KW - Antineoplastic agents--fluorouracil--combined therapy, solid tumors, discussion;
KW - Combined therapy--antineoplastic agents--tumors, solid, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kohn, Melvin L.
T1 - LOOKING BACK-A 2-YEAR REVIEW AND APPRAISAL OF SOCIAL PROBLEMS RESEARCH.
JO - Social Problems
JF - Social Problems
Y1 - 1976/10//
VL - 24
IS - 1
M3 - Article
SP - 94
SN - 00377791
AB - Research in the area of social problems, covering 1950-75, needs further methodological refinement and the psychological impact of social structure, cross-national research, social and individual change, and intersocial interaction need exploration.
KW - SOCIAL problems
KW - SOCIOLOGICAL research
KW - SOCIAL structure
KW - SOCIAL change
KW - SOCIAL movements
KW - APPLIED sociology
KW - HISTORICAL research
N1 - Accession Number: 4837585; Kohn, Melvin L. 1; Affiliations: 1 : National Institute of Mental Health.; Source Info: Oct76, Vol. 24 Issue 1, p94; Historical Period: 1950 to 1975; Subject Term: SOCIAL problems; Subject Term: SOCIOLOGICAL research; Subject Term: SOCIAL structure; Subject Term: SOCIAL change; Subject Term: SOCIAL movements; Subject Term: APPLIED sociology; Subject Term: HISTORICAL research; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
ID - 2013-42022-019
AN - 2013-42022-019
AU - Shore, Milton F.
T1 - Review of The uses of enchantment: The meaning and importance of fairy tales.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1976/10//
VL - 46
IS - 4
SP - 727
EP - 728
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42022-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Fantasy; Folklore. Minor Descriptor: Violence. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). Reviewed Item: Bettelheim, Bruno. The uses of enchantment: The meaning and importance of fairy tales=328 pp. $12.50. Knopf, New York; 1976. Page Count: 2. Issue Publication Date: Oct, 1976.
AB - Reviews the book, The Uses of Enchantment: The Meaning and Importance of Fairy Tales by Bruno Bettelheim (1976). The author pleads for greater recognition and use of fairy tales as symbolic forms, important and necessary for the adequate resolution of certain developmental issues. The author defends fairy tales against all critics, even accepting the primitive violence in many tales by the Grimms as merely reflecting the intense hostility that permeates the fantasy life of the preschool child. The book has two sections. The first describes vividly the power of magic in the fantasy of the young child and the general content areas, processes, and principles that are played out in fairy tales. The second is a detailed analysis of such well-known fairy tales as Snow White and Cinderella. The book does not dwell on the historical, literary, or educational aspects of fairy tales. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - enchantment
KW - fairy tales
KW - childhood development
KW - primitive violence
KW - fantasy
KW - 1976
KW - Childhood Development
KW - Fantasy
KW - Folklore
KW - Violence
KW - 1976
U2 - Bettelheim, Bruno. (1976); The uses of enchantment: The meaning and importance of fairy tales; 328 pp. $12.50. Knopf, New York
DO - 10.1037/h0098760
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FAMIGLIETTI JR., E. V.
AU - KOLB, HELGA
T1 - Structural Basis for ON- and OFF-Center Responses in Retinal Ganglion Cells.
JO - Science
JF - Science
Y1 - 1976/10/08/
VL - 194
IS - 4261
M3 - Article
SP - 193
EP - 195
SN - 00368075
AB - The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive field center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218162; FAMIGLIETTI JR., E. V. 1; KOLB, HELGA 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20014; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda; Issue Info: 10/ 8/1976, Vol. 194 Issue 4261, p193; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Rozencweig, M.;
AU - Slavik, M.;
AU - Muggia, F. M.;
T1 - Activity of daunomycin in solid tumors
CT - Activity of daunomycin in solid tumors
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/10/11/
VL - 236
IS - Oct 11
SP - 1693
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 14-0693; Language: English; Trade Name: Daunomycin; Generic Name: Daunorubicin; Chemical Name: Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 3; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - It was stated that there is an inadequate amount of information presently available to confirm whether daunomycin (daunorubicin) is active or inactive in treating solid tumors in humans.
KW - Daunorubicin--tumors-;
KW - Rational therapy--daunorubicin--tumors, solid, lack of adequate information, patients;
KW - Antineoplastic agents--daunorubicin--tumors, solid, rational therapy, lack of adequate information, patients;
KW - Drug information--daunorubicin--lack, rational therapy of solid tumors, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PERT, CANDACE B.
AU - PERT, AGU
AU - CHANG, JAW-KANG
AU - FONG, Bosco T. W.
T1 - [D-Ala²]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic.
JO - Science
JF - Science
Y1 - 1976/10/15/
VL - 194
IS - 4262
M3 - Article
SP - 330
EP - 332
SN - 00368075
AB - [D-Ala²]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine- enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218204; PERT, CANDACE B. 1; PERT, AGU 1; CHANG, JAW-KANG 2; FONG, Bosco T. W. 2; Affiliations: 1: Section on Biochemistry, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Bioproducts Department, Beckman Instruments, Inc., Palo Alto, California 94304; Issue Info: 10/15/1976, Vol. 194 Issue 4262, p330; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BUCHSBAUM, MONTE S.
AU - COURSEY, ROBERT D.
AU - MURPHY, DENNIS L.
T1 - The Biochemical High-Risk Paradigm: Behavioral and Familial Correlates of Low Platelet Monoamine Oxidase Activity.
JO - Science
JF - Science
Y1 - 1976/10/15/
VL - 194
IS - 4262
M3 - Article
SP - 339
EP - 341
SN - 00368075
AB - A population of individuals potentially at risk for psychiatric disorders was identified by screening 375 college student volunteers for low platelet monoamine oxidase (MAO) activity levels. The lower and upper 10 percent in MAO activity were interviewed and family history data were obtained. Low-MAO probands reported more frequent psychiatric or psychological counseling and problems with the law. Families of low-MAO probands had an eightfold increase in the incidence of suicide or suicide attempts over those of high-MAO probands. This suggests that reduced MAO levels, reported previously in patients with affective disorders and chronic schizophrenia, may predict a vulnerability to psychiatric disorder. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218209; BUCHSBAUM, MONTE S. 1; COURSEY, ROBERT D. 2; MURPHY, DENNIS L. 3; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20016; 2: Department of Psychology, University of Maryland, College Park 20740; 3: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 10/15/1976, Vol. 194 Issue 4262, p339; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Licata, A. A.;
AU - Bartter, F. C.;
T1 - Spironolactone induced gynecomastia related to allergic reaction to Darvon Compound
CT - Spironolactone induced gynecomastia related to allergic reaction to Darvon Compound
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/10/23/
VL - 2
IS - Oct 23
SP - 905
SN - 00237507
AD - Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-1061; Language: English; Trade Name: Darvon Compound-65; Generic Name: Aspirin; Chemical Name: Spironolactone--52-01-7 Aspirin--50-78-2 Caffeine--58-08-2 Phenacetin--62-44-2 Propoxyphene hydrochloride--1639-60-7; Therapeutic Class: (40:28); AHFS Class: Diuretics spironolactone; References: 5; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions; Abstract Author: Joan Lentine
N2 - Reported is an episode of transient gynecomastia in a 58-yr-old white man which developed 4 yr after treatment with spironolactone had been started and was temporally related to an allergic reaction provoked by the analgesic Darvon Compound-65 (aspirin 230 mg, caffeine 30 mg, phenacetin 150 mg and propoxyphene hydrochloride 65 mg; I). It is unusual for spironolactone to produce gynecomastia for the first time after many yr of use. The allergic reaction to I was considered a precipitating cause. Although this patient had previously taken propoxyphene HCl without an allergic reaction, it is not certain which of the other components in I is responsible for the allergy. Because the patient developed symptoms similar to those of his original reaction when he was challenged with I while he was taking spironolactone, there does seem to be a relation. Whether I specifically or the allergic reaction it provoked increased the sensitivity to spironolactone is uncertain.
KW - Spironolactone--interactions-;
KW - Aspirin--combination, caffeine, phenacetin, propoxyphene hydrochloride-;
KW - Caffeine--combination, aspirin, phenacetin, propoxyphene hydrochloride-;
KW - Phenacetin--combination, aspirin, caffeine, propoxyphene hydrochloride-;
KW - Propoxyphene hydrochloride--combination, aspirin, caffeine, phenacetin-;
KW - Drug interactions--spironolactone and aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride--gynecomastia, transient, patient;
KW - Drug interactions--aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride and spironolactone--gynecomastia, transient, patient;
KW - Diuretics--spironolactone--interactions, aspirin, combination, caffeine, phenacetin, propoxyphene, transient gynecomastia, patient;
KW - Drugs, adverse reactions--spironolactone and aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride--gynecomastia, transient, patient;
KW - Drugs, adverse reactions--aspirin, combination, caffeine, phenacetin, propoxyphene hydrochloride and spironolactone--gynecomastia, transient, patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PALMER, LAWRENCE G.
AU - GULATI, JAGDISH
T1 - Potassium Accumulation in Muscle: A Test of the Binding Hypothesis.
JO - Science
JF - Science
Y1 - 1976/10/29/
VL - 194
IS - 4264
M3 - Article
SP - 521
EP - 523
SN - 00368075
AB - Livingfrog skeletal muscle can accumulate potassium in vitro to concentrations up to 580 millimolar. Both the amount of potassium accumulated and the relationship between intracellular and extracellular potassium concentrations indicate that potassium is "free" under all conditions, rather than bound to cellular macromolecules. The data also indicate that at most 20 percent of the cell water is "bound" in the sense that it excludes electrolytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436999; PALMER, LAWRENCE G. 1; GULATI, JAGDISH 2; Affiliations: 1: Department of Physiology, University of Pennsylvania, Philadelphia 19174; 2: Laboratory of Physical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 10/29/1976, Vol. 194 Issue 4264, p521; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MARTIN, W. J.
AU - GIPSON, T. G.
AU - MARTIN, S. E.
AU - RICE, J. M.
T1 - Derepressed Alloantigen on Transplacentally Induced Lung Tumor Coded for by H-2 Linked Gene.
JO - Science
JF - Science
Y1 - 1976/10/29/
VL - 194
IS - 4264
M3 - Article
SP - 532
EP - 533
SN - 00368075
AB - A transplacentally induced lung tumor of strain C3Hf mice grows progressively when transplanted to (C3Hf x A)F1 hybrid mice but not when transplanted to C3Hf recipients. Progressive tumor growth occurs in [(C3Hf x A)F1 x C3Hfl backcross mice inheriting the H-2a haplotype from the F1 parent. Furthermore, radioresistant immunity to the lung tumor can be induced in C3Hf mice by immunization with normal tissue of B1O.A and BIO.A(2R) but not of BJO or BIO.A(5R) strain mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436993; MARTIN, W. J. 1; GIPSON, T. G. 1; MARTIN, S. E. 2; RICE, J. M. 3; Affiliations: 1: Division of Virology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014; 2: Laboratory of Biochemical Genetics, National Heart and Lung Institute, Bethesda, Maryland 20014; 3: Experimental Pathology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/29/1976, Vol. 194 Issue 4264, p532; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Loriaux, D. L.;
AU - Menard, R.;
AU - Taylor, A.;
AU - Pita, J. C.;
AU - Santen, R.;
T1 - Spironolactone and endocrine dysfunction
CT - Spironolactone and endocrine dysfunction
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/11/01/
VL - 85
IS - Nov
SP - 630
EP - 636
SN - 00034819
AD - Endocrinology Service Unit, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-5534; Language: English; Chemical Name: Spironolactone--52-01-7; Therapeutic Class: (40:28); AHFS Class: Diuretics spironolactone; References: 39; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology
N2 - This conference presents a discussion of how differing mechanisms might interact to produce the endocrine side effects associated with spironolactone therapy. Therapy with spironolactone is often associated with estrogen-like side effects, including impotence and gynecomastia in men and menstrual irregularity in women. Several possible mechanisms by which spironolactone could cause these side effects have been identified. Spironolactone has been shown to affect both gonadal and adrenal steroidogenesis, to elevate plasma gonadotropin levels in children, and to act as an antiandrogen at the target tissue level. Although the exact mechanism by which spironolactone causes its unpleasant side effects remains unidentified, its effects on steroid biosynthesis and androgen action have been described.
KW - Spironolactone--toxicity-;
KW - Diuretics--spironolactone--toxicity, mechanism of action, endocrine side effects;
KW - Mechanism of action--spironolactone--side effects, endocrine, review;
KW - Toxicity--spironolactone--mechanism of action, endocrine side effects;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Glinski, W.
AU - Gershwin, M. E.
AU - Budman, D. R.
AU - Steinberg, A. D.
T1 - Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/11//
VL - 26
IS - 2
M3 - Article
SP - 228
EP - 238
PB - Wiley-Blackwell
SN - 00099104
AB - Peripheral blood lymphocytes of thirty normal volunteers and fifty-two patients with systemic lupus erythematosus were fractionated using a discontinuous (5-30%) Ficoll gradient. Such fractionation permitted the isolation, identification and study of null cells, T cells and B cells. Patients with inactive SLE were found to have a cell distribution and responsiveness to PHA, Con A and Pokeweed mitogen (PWM) similar to controls. In contrast, patients with active SLE showed a significant decrease in T-cell fractions as well as a relative increase in null cells, a normal distribution of B cells, a marked reduction in responsiveness to Con A, a lesser reduction to PHA and only a minor reduction to PWM. With increasing disease activity, the number of null cells increased despite lymphopenia. Spontaneous lymphocyte transformation was observed in patients with SLE. This occurred predominantly in the fractions enriched in B cells and was observed both early (0-16 hr) and late (68-72 hi) in the lymphocyte cultures. The method of discontinuous Ficoll gradients is both versatile and reproducible with good correlations between isolated lymphoid suhpopulations and disease activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - AUTOIMMUNE diseases
KW - LYMPHOCYTES
KW - CELL fractionation
KW - FICOLL
KW - DENSITY gradient centrifugation
KW - POKEWEED mitogens
KW - IMMUNOCYTOCHEMISTRY
N1 - Accession Number: 15946755; Glinski, W. 1,2 Gershwin, M. E. 1,2 Budman, D. R. 1,2 Steinberg, A. D. 1,2; Affiliation: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland. 2: The Section of Rheumatology-Clinical Immunology, School of Medicine, University of California, California, U.S.A.; Source Info: Nov1976, Vol. 26 Issue 2, p228; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: AUTOIMMUNE diseases; Subject Term: LYMPHOCYTES; Subject Term: CELL fractionation; Subject Term: FICOLL; Subject Term: DENSITY gradient centrifugation; Subject Term: POKEWEED mitogens; Subject Term: IMMUNOCYTOCHEMISTRY; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takeichi, Noritoshi
AU - Boone, C. W.
AU - Klein, E.
T1 - Local adoptive transfer to mice of human delayed hypersensitivity.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1976/11//
VL - 26
IS - 2
M3 - Article
SP - 310
EP - 313
PB - Wiley-Blackwell
SN - 00099104
AB - Human delayed hypersensitivity to living BCG organisms and/or Varidase was adoptively transferred to mice and assayed in mice by a radioisotope footpad assay (FPA). A mixture of the antigen and peripheral blood lymphocytes from patients (positive skin reactions to PPD and/or Varidase) or healthy volunteers was inoculated into the footpads of lethally X-irradiated mice. A positive footpad reaction was accompanied by an increased leakage of the radiolabelled serum protein from the blood stream into the intercellular space at the site of inoculation, and was measured by the `foot-count ratio', or radioactivity in the test foot divided by radioactivity in the contralateral foot. The intensity of the footpad reaction correlated directly with the skin test response of the human lymphocyte donors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DELAYED hypersensitivity
KW - CELLULAR immunity
KW - BCG vaccination
KW - LYMPHOCYTES
KW - RADIOISOTOPES -- Therapeutic use
KW - BLOOD donors
KW - SKIN tests
N1 - Accession Number: 15947133; Takeichi, Noritoshi 1 Boone, C. W. 1 Klein, E. 2; Affiliation: 1: Cell Biology Section, Laboratory of Viral Carcinogenesis, Viral Oncology Program, National Cancer Institute, U.S. Department of Health, Education and Welfare, Bethesda, Maryland. 2: Department of Dermatology, Roswell Park Memorial Institute, Buffalo, N. Y., U.S.A.; Source Info: Nov1976, Vol. 26 Issue 2, p310; Subject Term: DELAYED hypersensitivity; Subject Term: CELLULAR immunity; Subject Term: BCG vaccination; Subject Term: LYMPHOCYTES; Subject Term: RADIOISOTOPES -- Therapeutic use; Subject Term: BLOOD donors; Subject Term: SKIN tests; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Chang, P.;
AU - Riggs, C. E.;
AU - Scheerer, M. T.;
AU - Wiernik, P. H.;
AU - Bachur, N. R.;
T1 - Combination chemotherapy with adriamycin and streptozotocin. 2. Clinicopharmacologic correlation of augmented adriamycin toxicity caused by streptozotocin
CT - Combination chemotherapy with adriamycin and streptozotocin. 2. Clinicopharmacologic correlation of augmented adriamycin toxicity caused by streptozotocin
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1976/11/01/
VL - 20
IS - Nov
SP - 611
EP - 616
SN - 00099236
AD - Sections of Medical Oncology and Biochemistry, Baltimore Cancer Research Center, National Cancer Institute, Baltimore, Maryland
N1 - Accession Number: 14-5045; Language: English; Trade Name: Adriamycin--Streptozotocin; Generic Name: Doxorubicin; Streptozocin; Chemical Name: Doxorubicin--23214-92-8 Streptozocin--18883-66-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin (10:00); AHFS Class: Antineoplastic agents streptozocin; References: 17; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Interactions
N2 - Plasma pharmacokinetics were compared in patients with advanced sarcomas receiving adriamycin (doxorubicin; I), 60 mg/sq m, IV on day one every 3 weeks in combination with streptozotocin (streptozocin; II), 500 mg/sq m/day IV on days one to 5 every 3 weeks, and patients receiving I alone in the same dose and schedule. The combination treated group had greater I drug exposure (concentration \X/ time) when serial plasma levels were analyzed by fluorescence assay and by radioimmunoassay. The plasma half-life of I equivalents measured by fluorescence assay was also significantly prolonged in the combination treated group. These changes correlated well with an increase in I related toxicity\M/mucositis and myelosuppression\M/seen in the patients who received the combination drug therapy. Plasma II kinetics and the incidence of II related side effects\M/hepatic and renal function abnormalities\M/were those published for II alone. Evidence is presented to support the hypothesis that the increased incidence of I side effects is due to II related hepatic dysfunction, affecting both the detoxification and excretion of I. Combination of other drugs with I should take into account their potential for inducing hepatic dysfunction which may affect the therapeutic index of I.
KW - Doxorubicin--interactions-;
KW - Streptozocin--interactions-;
KW - Drug interactions--doxorubicin and streptozocin--toxicity, hepatic, enhanced, and pharmacokinetics, advanced sarcoma patients;
KW - Drug interactions--streptozocin and doxorubicin--toxicity, hepatic, enhanced, and pharmacokinetcs, advanced sarcoma patients;
KW - Antineoplastic agents--doxorubicin--interactions, streptozocin, enhanced hepatic toxicity, and pharmacokinetics, advanced sarcoma patients;
KW - Antineoplastic agents--streptozocin--interactions, doxorubicin, enhanced hepatic toxicity, and pharmacokinetics, advanced sarcoma patients;
KW - Toxicity--doxorubicin--interactions, streptozocin, enhanced hepatic, and pharmacokinetics, advanced sarcoma patients;
KW - Toxicity--streptozocin--interactions, doxorubicin, enhanced hepatic, and pharmacokinetics, advanced sarcoma patients;
KW - Pharmacokinetics--doxorubicin--alone and with streptozocin, blood levels and half-life, enhanced hepatic toxicity, advanced sarcoma patients;
KW - Pharmacokinetics--streptozocin and doxorubicin--blood levels, and half-life, enhanced hepatic toxicity, advanced sarcoma patients;
KW - Blood levels--doxorubicin--alone and with streptozocin, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW - Blood levels--streptozocin and doxorubicin--pharmacokinetics, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW - Half-life--doxorubicin--alone and with streptozocin, relation to enhanced hepatic toxicity, advanced sarcoma patients;
KW - Half-life--streptozocin and doxorubicin--pharmacokinetics, relation to enhanced hepatic toxicity, advanced sarcoma patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Grove, W. R.;
AU - Bender, J. R.;
AU - Fortner, C. L.;
AU - Strauss, G.;
AU - Wiernik, P. H.;
T1 - Benzquinamide-induced extrapyramidal reaction
CT - Benzquinamide-induced extrapyramidal reaction
JO - Drug Intell. Clin. Pharm.
JF - Drug Intell. Clin. Pharm.
Y1 - 1976/11/01/
VL - 10
IS - Nov
SP - 638
EP - 639
AD - National Cancer Institute, Baltimore Cancer Research Center at the Univ. of Maryland Hospital, Baltimore, Maryland
N1 - Accession Number: 14-2505; Language: English; Chemical Name: Benzquinamide--63-12-7 Diphenhydramine--58-73-1; Therapeutic Class: (56:22); AHFS Class: Anti-emetics benzquinamide (4:00); AHFS Class: Antihistamines diphenhydramine; References: 6; Journal Coden: DICPBB; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - A case report of a patient who developed an extrapyramidal reaction following the IM administration of 50 mg benzquinamide is presented. This reaction has not been previously reported. Prior to this, the patient had reacted similarly to prochlorperazine. Diphenhydramine was useful in reversing the reaction on both occasions.
KW - Benzquinamide--adverse reactions-;
KW - Diphenhydramine--effects-;
KW - Drugs, adverse reactions--benzquinamide--extrapyramidal, diphenhydramine therapy, case report;
KW - Anti-emetics--benzquinamide--adverse reactions, extrapyramidal, diphenhydramine therapy, case report;
KW - Antihistamines--diphenhydramine--effects, extrapyramidal symptoms, benzquinamide induced, case report;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rosseneu, Maryvonne
AU - Soetewey, Frederick
AU - Peeters, Hubert
AU - Bausserman, Linda L.
AU - Herbert, Peter N.
T1 - Interaction of the Apoproteins of Very Low Density and High Density Lipoproteins with Synthetic Phospholipids.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/11//Nov76 Part 1
VL - 70
IS - 1
M3 - Article
SP - 285
EP - 289
PB - Wiley-Blackwell
SN - 00142956
AB - The interaction of synthetic dimyristoyl phosphatidylcholine (lecithin) liposomes with isolated apoC-I and apoC-III proteins from very low density lipoproteins has been studied by micro- calorimetry. Complex formation is a highly exothermal process characterized by a maximal enthalpy of -130 kcal/mol (-544 kJ) apoC-III-1 and -65 kcal mol apoC-I proteins (-272 kJ). The complex composition determined after its isolation by ultracentrifugal flotation agrees with the value derived from the enthalpy binding curves. The binding of a constant amount of dimyristoyl lecithin to apoprotein mixtures containing various proportions of apoA-I and apoC-III failed to demonstrate the existence of any preferential association between the two apoproteins, in contrast with results obtained previously with apoA-I/ apoA-II protein mixtures. Finally the various contributions to the enthalpy of binding such as that arising from an increase in apoprotein helicity have been evaluated. A classification of the apolipoproteins according so their lipid-binding affinity is proposed as: apoA-II [This symbol cannot be presented in ASCII format] apoC-III > apoC-I > apoA-I proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIPOPROTEINS
KW - PHOSPHOLIPIDS
KW - MOLECULAR association
KW - LECITHIN
KW - LIPOSOMES
KW - DENSITY
KW - BIOCHEMISTRY
N1 - Accession Number: 13581302; Rosseneu, Maryvonne 1 Soetewey, Frederick 1 Peeters, Hubert 1 Bausserman, Linda L. 1 Herbert, Peter N. 1; Affiliation: 1: Simon Stevin Instituut voor Wetenschappelijk Onderzock, Brugge, and Section of Lipoprotein Structure, Molecular Disease Branch, National Heart & Lung Institute, National Institutes of Health, Bethesda; Source Info: Nov76 Part 1, Vol. 70 Issue 1, p285; Subject Term: LIPOPROTEINS; Subject Term: PHOSPHOLIPIDS; Subject Term: MOLECULAR association; Subject Term: LECITHIN; Subject Term: LIPOSOMES; Subject Term: DENSITY; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Gail, M.;
AU - Williams, R.;
AU - Byar, D. P.;
AU - Brown, C.;
T1 - How many controls?
CT - How many controls?
JO - J. Chronic Dis.
JF - J. Chronic Dis.
Y1 - 1976/11/01/
VL - 29
IS - Nov
SP - 723
EP - 731
AD - Clinical and Diagnostic Trials Section, National Cancer Institute, NIH, Landow Bldg., Rm. C-509, Bethesda, MD 20014
N1 - Accession Number: 15-1337; Language: English; References: 10; Journal Coden: JOCDAE; Section Heading: Methodology; Abstract Author: Nancy Seren
N2 - The paper discusses how many controls are needed for a study comparing responses in only 2 groups, and those situations where it is appropriate to deviate from equal allocation in fixed sample clinical trials. Given unequal allocation, randomization to assign the subject to a treatment still applies; the only change being the odds of assignment to a group become K to 1.
KW - Clinical studies--control--need, unequal allocation;
KW - Control--clinical studies--need, unequal allocation;
KW - Methodology--clinical studies--need, controls;
KW - Statistics--clinical studies--need, controls;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Feldmann, R J
T1 - Quality control of chemical data bases
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1976/11//
VL - 16
IS - 4
M3 - Article
SP - 232
EP - 233
SN - 00952338
AB - The problems of quality control of the data in the files that comprise the epa-nih chemical information system (cis) are described and discussed. The use of the chemical abstracts registry numbers (regn) in these data bases is also described.
N1 - Accession Number: ISTA1201706; Feldmann, R J 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland; Source Info: November 1976, Vol. 16 Issue 4, p232; Note: Update Code: 1200; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Hirata, T.;
AU - Driscoll, J. S.;
T1 - Potential CNS antitumor agents\M/phenothiazines. 1. Nitrogen mustard derivatives
CT - Potential CNS antitumor agents\M/phenothiazines. 1. Nitrogen mustard derivatives
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/11/01/
VL - 65
IS - Nov
SP - 1699
EP - 1701
SN - 00223549
AD - Drug Design and Chemistry Section, Laboratory of Medicinal Chemistry and Biology, Drug Research and Development Program, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-1137; Language: English; References: 23; Publication Type: Notes; Journal Coden: JPMSAE; Section Heading: Preliminary Drug Testing; Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2 - Synthesis of 4 phenothiazine derivatives containing the bis(\b/-chloroethyl)aminopropyl side chain is presented. These analogs were tested against murine L-1210, P-388 and B-16 melanomas and compared to the activity of aminoethyl phenothiazine mustards. The aminoethyl derivatives were superior in all test systems.
KW - Phenothiazines--bis(\b/-chloroethyl)aminopropyl--synthesis, and antineoplastic activity, in vitro;
KW - Antineoplastic agents--phenothiazines--bis(\b/-chloroethyl)aminopropyl, synthesis and activity, in vitro;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06280-035
AN - 2006-06280-035
AU - Russo, Nancy Felipe
T1 - On the Psychology of Women: The Competition for the Market Begins.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1976/11//
VL - 21
IS - 11
SP - 818
EP - 819
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06280-035. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Russo, Nancy Felipe; Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, MD, Iceland. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior; Experience Level; Human Females; Psychology of Women. Minor Descriptor: Competition. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Deaux, Kay. The Behavior of Women and Men=Monterey, Calif.: Brooks/Cole, 1976. Pp. xi + 168. $4.95; 1976. Hyde, Janet Shibley; Rosenberg, B. G. Half the Human Experience: The Psychology of Women=Lexington, Mass.: Heath, 1976. Pp. xiii + 306. $4.95 paper; 1976. Page Count: 2. Issue Publication Date: Nov, 1976.
AB - Reviews the books, The Behavior of Women and Men by Kay Deaux (1976) and Half the Human Experience: The Psychology of Women by Janet Shibley Hyde and B. G. Rosenberg (see record [rid]1976-20603-000[/rid]). Deaux integrates a considerable number of findings from the traditional social psychological literature. The author's style is highly readable, interspersed with anecdotes that tie the laboratory to daily experience. A book that provides a broad coverage of the female experience is sorely needed, and Half the Human Experience contains a wealth of interesting information and insights. Perhaps the book's most detrimental characteristic is its treatment of biological contributions to development. The style and attractiveness are undeniably crucial to good pedagogy, the effects of such pressure are potentially beneficial. Both the are groundbreakers in a new market, and a multitude of competitors can be expected to follow. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women psychology
KW - human experience
KW - women behavior
KW - men behavior
KW - 1976
KW - Behavior
KW - Experience Level
KW - Human Females
KW - Psychology of Women
KW - Competition
KW - 1976
U2 - Deaux, Kay. (1976); The Behavior of Women and Men; Monterey, Calif.: Brooks/Cole, 1976. Pp. xi + 168. $4.95
U2 - Hyde, Janet Shibley; Rosenberg, B. G. (1976); Half the Human Experience: The Psychology of Women; Lexington, Mass.: Heath, 1976. Pp. xiii + 306. $4.95 paper
DO - 10.1037/014730
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06280-049
AN - 2006-06280-049
AU - Zifferblatt, Steven M.
T1 - Chronic Pain and Illness With Patients and With Scientific Methodology.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1976/11//
VL - 21
IS - 11
SP - 834
EP - 835
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06280-049. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zifferblatt, Steven M.; NIH National Heart, Lung, and Blood Institute, Bethesda, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Chronic Illness; Chronic Pain; Experimental Methods; Social Processes. Minor Descriptor: Pain. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Reviewed Item: Fordyce, Wilbert E. Behavioral Methods for Chronic Pain and Illness=St. Louis, Mo.: Mosby, 1976. Pp. ix + 236. $9.50; 1976. Page Count: 2. Issue Publication Date: Nov, 1976.
AB - Reviews the book, Behavioral Methods for Chronic Pain and Illness by Wilbert E. Fordyce (1976). The book provides the first comprehensive, clinically based system for managing and evaluating chronic pain and illness. The book tends to prescribe treatment techniques rather than a problem resolution process in the management of chronic pain and illness. Pain is defined, in part, as a social response and maintained by social events available at home, at leisure, or at work. Several excellent case study examples of how to modify and capitalize on these functional relationships are provided in this book. Most important practical and administrative details on program implementation are included in several chapters. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral methods
KW - chronic pain and illness
KW - social events
KW - scientific methodology
KW - 1976
KW - Chronic Illness
KW - Chronic Pain
KW - Experimental Methods
KW - Social Processes
KW - Pain
KW - 1976
U2 - Fordyce, Wilbert E. (1976); Behavioral Methods for Chronic Pain and Illness; St. Louis, Mo.: Mosby, 1976. Pp. ix + 236. $9.50
DO - 10.1037/014744
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06280-049&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-15321-005
AN - 2005-15321-005
AU - Gallup, Gordon G. Jr.
AU - Ledbetter, David H.
AU - Maser, Jack D.
T1 - Strain Differences Among Chickens in Tonic Immobility: Evidence for an Emotionality Component.
JF - Journal of Comparative and Physiological Psychology
JO - Journal of Comparative and Physiological Psychology
JA - J Comp Physiol Psychol
Y1 - 1976/11//
VL - 90
IS - 11
SP - 1075
EP - 1081
CY - US
PB - American Psychological Association
SN - 0021-9940
N1 - Accession Number: 2005-15321-005. PMID: 993390 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Gallup, Gordon G. Jr.; State University of New York, Albany, NY, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Emotionality; Animal Strain Differences; Chickens; Tonic Immobility. Minor Descriptor: Animal Breeding; Hybrids (Biology). Classification: Genetics (2510). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 1976. Copyright Statement: American Psychological Association. 1976.
AB - Substantial strain differences in tonic immobility were found between different breeds of chickens. Crossbreeding between strains showing different immobility durations yielded hybrids that exhibited intermediate reactions. For purposes of relating the strain differences in tonic immobility to more conventional measures of emotionality, data were collected on open-field activity, defecation, and adrenal weight. Overall, the results implicated strain-specific differences in emotionality as being the basis for the observed differences in immobility. Latency to defecate in an open field, however, was highly correlated with latency to ambulate. It was argued that defecation, rather than being an absolute measure of fear or emotionality, may in fact be an intermediate response to gradual fear reduction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - emotionality
KW - tonic immobility
KW - strain differences
KW - chickens
KW - breeds
KW - hybrids
KW - 1976
KW - Animal Emotionality
KW - Animal Strain Differences
KW - Chickens
KW - Tonic Immobility
KW - Animal Breeding
KW - Hybrids (Biology)
KW - 1976
DO - 10.1037/h0078662
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hamel, Ernest
T1 - Derivatives of Guanosine Triphosphate with Ribose 2'-Hydroxyl Substituents.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/11/15/Nov76 Part 2
VL - 70
IS - 2
M3 - Article
SP - 339
EP - 347
PB - Wiley-Blackwell
SN - 00142956
AB - This report describes the preparation of four methylated and phosphorylated derivatives of GTP, 2′-O-methylguanosine 5′-triphosphate (PPP-Me2′ Guo), guanosine 2′- monophosphate 5′-triphosphate (PPP-Guo-2′P), 3′-O-methylguanosine 5′-triphosphate (PPP-Me3′Guo), and guanosine 3′-monophosphate 5′-triphosphate (PPP-Guo-3′P). These compounds were compared to GTP in their ability to support reactions catalyzed by Escherichia coli initiation factor 2 (IF-2), elongation factor Tu (EF-Tu), and elongation factor G (EF-G). As with previously studied GTP analogues, the nucleotide specificities of IF-2-dependent N-formylmethionylpuromycin formation and EF-Tu-dependent Ac-Phe2-tRNA formation were similar. There was little difference between the reactions supported by GTP, PPP-M2′ Guo, PPP-Me3′ Guo, and PPP-Guo-3′P, but PPP-Guo-2′P was a poor substrate with both enzymes. A spectrum of activity was observed in EF-G-dependent formation of N-acetylphenylalanyl-phenylalanylpuromycin. While PPP-Me2′ Guo was almost as effective as GTP in supporting translocation, PPP-Guo-2′P was a very poor substrate, having even less activity than guanosine 3′-diphosphate 5′-triphosphate. Intermediate activities were observed with PPP-Me3′ Guo and PPP-Guo-3′P, the former nucleotide being more active than the latter. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUANOSINE triphosphate
KW - RIBOSE phosphates
KW - PHOSPHATES
KW - HYDROXYL group
KW - METHYLATION
KW - NUCLEOTIDES
N1 - Accession Number: 13581318; Hamel, Ernest 1; Affiliation: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Nov76 Part 2, Vol. 70 Issue 2, p339; Subject Term: GUANOSINE triphosphate; Subject Term: RIBOSE phosphates; Subject Term: PHOSPHATES; Subject Term: HYDROXYL group; Subject Term: METHYLATION; Subject Term: NUCLEOTIDES; Number of Pages: 9p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huang, Freesia L.
AU - Glinsmann, Walter H.
T1 - Separation and Characterization of Two Phosphorylase Phosphatase Inhibitors from Rabbit Skeletal Muscle.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1976/11/15/Nov76 Part 2
VL - 70
IS - 2
M3 - Article
SP - 419
EP - 426
PB - Wiley-Blackwell
SN - 00142956
AB - Two heat-Stable and trypsin-labile inhibitors of phosphorylase phosphatase, designated inhibitor-1 and inhibitor-2, were partially purified from extracts of rabbit skeletal muscle by heating and column chromatography using DEAE-cellulose and Bio-gel P-60. Inhibitor-1 exists in an active phosphorylated form and an inactive dephosphorylated form. The interconversion of phosphorylated inhibitor-1 and dephosphorylated inhibitor-1 is mediated by protein kinase dependent on adenosine 3′:5′-monophosphate (cyclic AMP) and a Mn2+-stimulated phosphoprotein phosphatase. Inhibitory activity of inhibitor-2 is not influenced by treatment with either the kinase or the Mn2+-stimulated phosphatase. The molecular weights of inhibitor-1 and inhibitor-2 estimated by sodium dodecylsulfate-polyacrylamide gel electrophoresis are 26000 and 33000 respectively. Both inhibitor-1 and inhibitor-2 inhibit phosphorylase phosphatase by a mechanism which appears to be non-competitive with respect to the substrate phosphorylase a. Inhibitor fractions at early stages of purification also inhibit cyclic-AMP-dependent histone phosphorylation, but this kinase inhibitory activity resides with a protein moiety which is separable from inhibitor-1 and inhibitor-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATASES
KW - ENZYME inhibitors
KW - RABBITS as laboratory animals
KW - MUSCLES
KW - PHOSPHORYLATION
KW - CHROMATOGRAPHIC analysis
KW - CYCLIC adenylic acid
KW - CHEMICAL reactions
N1 - Accession Number: 13581342; Huang, Freesia L. 1 Glinsmann, Walter H. 1; Affiliation: 1: Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: Nov76 Part 2, Vol. 70 Issue 2, p419; Subject Term: PHOSPHATASES; Subject Term: ENZYME inhibitors; Subject Term: RABBITS as laboratory animals; Subject Term: MUSCLES; Subject Term: PHOSPHORYLATION; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CYCLIC adenylic acid; Subject Term: CHEMICAL reactions; Number of Pages: 8p; Illustrations: 1 Chart, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaplan, Allen P.
T1 - ACTIVATION AND CONTROL MECHANISMS OF THE PLASMA KININ-FORMING SYSTEM AND ITS RELATIONSHIP TO COAGULATION AND FIBRINOLYSIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/11/15/
VL - 67
IS - 5 Part 2
M3 - Article
SP - 635
EP - 637
SN - 0022202X
AB - Hageman factor was initially identified as the surface-activated plasma protein which initiates the intrinsic coagulation pathway. This same protein was later shown to be required for the initiation of surface-activated kinin generation and fibrinolysis. When activated Hageman factor was isolated from human serum, a prealbumin fragment derived from Hageman factor was discovered, which was shown to convert prekallikrein to kallikrein, the enzyme that digests kininogen to yield bradykinin. Biologic materials that can activate Hageman factor include endotoxin, uric acid and pyrophosphate crystals.
KW - KALLIKREIN
KW - PANCREATIC secretions
KW - KININS
KW - BRADYKININ
KW - PROTEINS
KW - FIBRINOLYSIS
N1 - Accession Number: 12544434; Kaplan, Allen P. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda, Maryland, U.S.A.; Source Info: Nov76, Vol. 67 Issue 5 Part 2, p635; Subject Term: KALLIKREIN; Subject Term: PANCREATIC secretions; Subject Term: KININS; Subject Term: BRADYKININ; Subject Term: PROTEINS; Subject Term: FIBRINOLYSIS; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12544434
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fishman, Peter H.
AU - Brady, Roscoe O.
T1 - Biosynthesis and Function of Gangliosides.
JO - Science
JF - Science
Y1 - 1976/11/26/
VL - 194
IS - 4268
M3 - Article
SP - 906
EP - 915
SN - 00368075
N1 - Accession Number: 85361169; Fishman, Peter H. 1; Brady, Roscoe O. 2; Affiliations: 1: Research biochemist, Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 2: Chief, Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/26/1976, Vol. 194 Issue 4268, p906; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHO, HAN YONG
AU - CUTCHINS, ERNEST C.
AU - RHIM, JOHNG SIK
AU - HUEBNER, ROBERT J.
T1 - Revertants of Human Cells Transformed by Murine Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1976/11/26/
VL - 194
IS - 4268
M3 - Article
SP - 951
EP - 953
SN - 00368075
AB - Revertants of nonproducer human osteosarcoma (NPIKHOS) cells induced by Kirsten murine sarcoma virus were isolated after incubating at high temperature (40.5°C) overnight and subcloning at 36°C. The morphologic variants, from which murine sarcoma virus could no longer be rescued, had growth properties similar to those of the nontransformed, parent human osteosarcoma cells and did not release RNA-dependent DNA polymerase activity. These revertants were nontumorigenic in nude mice. The revertants supported leukemia virus growth and showed an enhanced sensitivity to murine sarcoma virus superinfection. Thus, the revertants were from human cells transformed by an oncogenic RNA virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361192; CHO, HAN YONG 1,2; CUTCHINS, ERNEST C. 1; RHIM, JOHNG SIK 3; HUEBNER, ROBERT J. 3; Affiliations: 1: Catholic University of America, Washington, D.C. 20064; 2: Microbiological Associates, Inc., Bethesda, Maryland 20014; 3: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/26/1976, Vol. 194 Issue 4268, p951; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
T1 - Naloxone
CT - Naloxone
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/12/01/
VL - 85
IS - Dec
SP - 765
EP - 768
SN - 00034819
AD - Div. of Research, Addiction Research Center, National Institute on Drug Abuse, Lexington, Kentucky
N1 - Accession Number: 14-3875; Language: English; Chemical Name: Naloxone--465-65-6; References: 24; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Naloxone is discussed, according to its' pharmacology, mechanism of action, and clinical uses.
KW - Naloxone--narcotic antagonists-;
KW - Narcotic antagonists--naloxone--effects, pharmacology, and mechanism of action, discussion;
KW - Mechanism of action--naloxone--effects, and pharmacology, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MacIntyre, Ross J.
AU - O'Brien, Stephen J.
T1 - INTERACTING GENE-ENZYME SYSTEMS IN DROSOPHILA.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1976/12//
VL - 10
M3 - Article
SP - 281
EP - 318
PB - Annual Reviews Inc.
SN - 00664197
AB - Focuses on the research about the genetics of Drosophila melanogaster. Details on the phenotypes of the morphological mutants; Effects of pyrimidine analogues on wing development; Characterization of the enzyme loci.
KW - RESEARCH
KW - GENETICS
KW - DROSOPHILA melanogaster
KW - PHENOTYPE
KW - PYRIMIDINES
KW - ENZYMES
N1 - Accession Number: 12409090; MacIntyre, Ross J. 1 O'Brien, Stephen J. 2; Affiliation: 1: Section of Genetics, Development, and Physiology, Cornell University, Ithaca, New York 2: Cell Biology Section, Viral Biology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland; Source Info: 1976, Vol. 10, p281; Subject Term: RESEARCH; Subject Term: GENETICS; Subject Term: DROSOPHILA melanogaster; Subject Term: PHENOTYPE; Subject Term: PYRIMIDINES; Subject Term: ENZYMES; Number of Pages: 38p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klein, Robert P.
AU - Durfee, Joan T.
T1 - Infants' Reactions to Unfamiliar Adults versus Mothers.
JO - Child Development
JF - Child Development
Y1 - 1976/12//
VL - 47
IS - 4
M3 - Article
SP - 1194
EP - 1196
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12191202; Klein, Robert P. 1 Durfee, Joan T. 1; Affiliation: 1: Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development.; Source Info: Dec1976, Vol. 47 Issue 4, p1194; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1467-8624.ep12191202
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Makinodan, T.
AU - Albright, Julia W.
AU - Good, P.I.
AU - Peter, C.P.
AU - Heidrick, Margaret L.
T1 - Reduced humoral immune activity in long-lived old mice: An approach to elucidating its mechanisms.
JO - Immunology
JF - Immunology
Y1 - 1976/12//
VL - 31
IS - 6
M3 - Article
SP - 903
EP - 911
PB - Wiley-Blackwell
SN - 00192805
AB - Spleen cells from young (3-5 months) and old (22-27 months) mice were assessed in cultures, both in vivo and in vitro, for their antisheep RBC response separately and in mixtures. Pooled young spleens, pooled old spleens, and individual old spleens were analysed. The response of pure young spleen cells was always higher than that of pure old spleen cells (∼30 times). The responses of mixtures were either less than (i.e. reduced; frequency ∼65 per cent), comparable to (i.e. additive; frequency ∼10 per cent), or greater than (i.e. elevated; frequency ∼30 per cent) the sum of the responses given by equivalent numbers of pure young and pure old spleen cells. The reduced response was observed in mixtures containing cells from histologically normal old spleens, old spleens with tumours and old spleens with atrophic follicles. Additive and elevated responses were observed only in mixtures containing cells from histologically normal old spleens. The reduced response is explicable in terms of excessive numbers of suppressor cells in old spleens that can prevent young immunocompetent cells from responding maximally to the test antigen. The additive response can be accounted for by a reduction in number of immunocompetent cells in old spleens and/or a decrease in their functional efficiency. The elevated response can be explained by a reduction in number of at least one type of immunocompetent cell in old spleens that exists in excess in young spleens. These results indicate that there are several types of cellular changes responsible for the decrease in humoral immune activity in old mice. Pooling of old spleens, as was commonly done in the past, should therefore be discouraged. Not only might it selectively favour the expression of old spleens with an excess of supressor cells but it conceivably could result in an elevated response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE system
KW - SPLEEN
KW - HEMATOPOIETIC system
KW - LYMPHOID tissue
KW - IMMUNOLOGY
KW - MICE
N1 - Accession Number: 13373699; Makinodan, T. 1,2 Albright, Julia W. 1 Good, P.I. 3 Peter, C.P. 2,4 Heidrick, Margaret L. 1,2,5; Affiliation: 1: Laboratory of Cellular and Comparative Physiology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, PHS, U.S. Department of health, Education and Welfare, Bethesda and Baltimore City Hospitals, Baltimore, Maryland 2: Oak Ridge National Laboratory, Oak Ridge, Tennessee 3: The Upjohn Company, Kalamazoo, Michigan 4: Merck, Sharp and Dohme, West Point, Pennsylvania 5: Department of Biochemistry, University of Nebraska, Omaha, Nebraska U.S.A.; Source Info: Dec76, Vol. 31 Issue 6, p903; Subject Term: IMMUNE system; Subject Term: SPLEEN; Subject Term: HEMATOPOIETIC system; Subject Term: LYMPHOID tissue; Subject Term: IMMUNOLOGY; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Hertz, Kenneth C.
AU - Gazze, Laura A.
AU - Katz, Stephen I.
T1 - IMMUNOFLUORESCENT LOCALIZATION OF BASEMENT MEMBRANE IN LESIONS OF DERMATITIS HERPETIFORMIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/12//
VL - 67
IS - 6
M3 - Report
SP - 683
EP - 687
SN - 0022202X
AB - Dermatitis herpetiformis (DH) is a blistering disease with a characteristic histology that includes papillary edema, neutrophilic papillary microabscesses, and development of subepidermal blisters. In spite of this pathologic sequence occurring entirely beneath the basement membrane zone, prior studies have indicated that the basement membrane, as defined by periodic acid-Schiff (PAS) or silver stains, lies at the floor of fully formed blisters or is destroyed by the disease process. To more accurately assess its location in primary lesions of DH, the basement membrane was stained using immunofluorescent techniques. Lesional skin from 5 patients with DH was used as substrate for indirect immunofluorescence with sera from patients with bullous pemphigoid (BP) and fluoresceinated antihuman IgG. The BP-stained basement membrane was attached to the roofs of early blisters, where it would be expected from the pathologic sequence of blister formation. PAS stains of the same or serial sections show the basement membrane to be in the roof or at the floor of the blisters. PAS stains of sections from formalin-fixed lesional skin, on the other hand, show the basement membrane to routinely lie at the blister floor, when not destroyed. The BP-stained epidermal basement membrane has greater anatomic and functional significance than either the PAS- or silver-stained basement membrane for two reasons: (1) it corresponds to a specific morphologic structure, the lamina lucida, a part of the epidermis, and remains attached to the rest of the epidermis unless destroyed; and (2) it is antigenic, capable of binding with BP antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOFLUORESCENCE
KW - BASAL lamina
KW - DERMATITIS herpetiformis
KW - SKIN diseases
KW - EPITHELIUM
KW - IMMUNOGLOBULINS
N1 - Accession Number: 12598497; Hertz, Kenneth C. 1 Gazze, Laura A. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec76, Vol. 67 Issue 6, p683; Subject Term: IMMUNOFLUORESCENCE; Subject Term: BASAL lamina; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: EPITHELIUM; Subject Term: IMMUNOGLOBULINS; Number of Pages: 5p; Document Type: Report
L3 - 10.1111/1523-1747.ep12598497
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katz, Stephen I.
AU - Hertz, Kennerth C.
AU - Crawford, Peggy S.
AU - Gazze, Laura A.
AU - Frank, Michael M.
AU - Lawley, Thomas J.
T1 - EFFECT OF SULFONES ON COMPLEMENT DEPOSITION IN DERMATITIS HERPETIFORMIS AND ON COMPLEMENT-MEDIATED GUINEA-PIG REACTIONS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/12//
VL - 67
IS - 6
M3 - Article
SP - 688
EP - 690
SN - 0022202X
AB - The role of complement and the mechanism of sulfone action in dermatitis herpetiformis (DH) have not yet been established; prior studies have presented conflicting data regarding the effect of sulfones on complement activation and deposition. Thirty-eight DH patients were studied. Twenty-four of 25 perilesional skin biopsies and 50 of 67 normal-appearing skin biopsies showed the third component of complement (C3) deposited in areas corresponding to those of IgA deposition. Nine of 10 patients with bound C3 in normal-appearing and perilesional skin during periods of active disease continued to have C3 in normal-appearing skin when treatment with sulfones kept them completely free of lesions for 2 to 8 weeks. When either Hartley-strain or C4-deficient guinea pigs were given up to 150 mg/kg sulfoxone (a water-soluble sulfone) intraperitoneally for 8 days before elicitation of active Arthus, reverse passive Arthus reactions, or Forssman shock, there was no difference in time course, character, or intensity of reactions when compared to saline-treated control animals. We were therefore unable to demonstrate any effect of sulfones on complement deposition in DH skin or on complement activation in classical or alternate complement pathway-mediated guinea-pig reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SULFONES
KW - DERMATITIS herpetiformis
KW - SKIN diseases
KW - IMMUNOGLOBULINS
KW - GUINEA pigs as laboratory animals
KW - SKIN -- Biopsy
N1 - Accession Number: 12598565; Katz, Stephen I. 1 Hertz, Kennerth C. 1 Crawford, Peggy S. 1 Gazze, Laura A. 1 Frank, Michael M. 1 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch and Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Dec76, Vol. 67 Issue 6, p688; Subject Term: SULFONES; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: GUINEA pigs as laboratory animals; Subject Term: SKIN -- Biopsy; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12598565
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaoita, Hideo
AU - Hertz, Kenneth C.
AU - Katz, Stephen I.
T1 - DERMATITIS HERPETIFORMIS: IMMUNOELECTRONMICROSCOPIC AND ULTRASTRUCTURAL STUDIES OF A PATIENT WITH LINEAR DEPOSITION OF IgA.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1976/12//
VL - 67
IS - 6
M3 - Article
SP - 691
EP - 695
SN - 0022202X
AB - Using immunoelectronmicroscopic techniques, we have demonstrated three distinct patterns of IgA deposition in the skin of patients with dermatitis herpetiformis. The least common of these patterns is the localization of reaction products to the lamina lucida. As this is the location of the immunoreactants in bullous pemphigoid and herpes gestationis and because the ultrastructural findings in our patient's early lesional skin differ from those usually seen in patients with dermatitis herpetiformis, we herein detail this patient's clinical, histologic, immunologic, and ultrastructural findings. The most prominent findings are (1) IgA deposition in the lamina lucida, (2) vesicle formation between basal lamina and the basal cells, and (3) fibrin-like material in the epidermis with showering into the dermis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATITIS herpetiformis
KW - SKIN diseases
KW - IMMUNOGLOBULINS
KW - ELECTRON microscopic diagnosis
KW - BASAL lamina
KW - EPIDERMIS
N1 - Accession Number: 12598569; Yaoita, Hideo 1 Hertz, Kenneth C. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Dec76, Vol. 67 Issue 6, p691; Subject Term: DERMATITIS herpetiformis; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: ELECTRON microscopic diagnosis; Subject Term: BASAL lamina; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12598569
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chapman, Judith-Anne W.
T1 - A Comparison of the X[sup2], -2 Log R, and Multinomial Probability Criteria for Significance Tests When Expected Frequencies Are Small.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1976/12//
VL - 71
IS - 356
M3 - Article
SP - 854
SN - 01621459
AB - The exact multinomial, and exact and Chi[sup 2] probabilities for X[sup 2] and -2 log R have been compared. The -2 log R Chi[sup 2] probabilities are on average closer to the multinomial than are the corresponding X[sup 2] probabilities. The differences between the exact and Chi[sup 2] probabilities are usually smaller for X[sup 2] than for -2 log R. A pattern was observed among the five types of significance levels, and an explanation was proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - CORRELATION (Statistics)
KW - MATHEMATICAL statistics
KW - REGRESSION analysis
KW - COMBINATIONS (Mathematics)
KW - PROBABILITY measures
KW - LEAST squares
N1 - Accession Number: 4608254; Chapman, Judith-Anne W. 1; Affiliations: 1: Research Fellow of the National Cancer Institute of Canada.; Issue Info: Dec76, Vol. 71 Issue 356, p854; Thesaurus Term: PROBABILITY theory; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: REGRESSION analysis; Subject Term: COMBINATIONS (Mathematics); Subject Term: PROBABILITY measures; Subject Term: LEAST squares; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - HARRIS, CURTIS C.
AU - AUTRUP, HERMAN
AU - CONNOR, ROBERT
AU - BARRETT, LUCY A.
AU - MCDOWELL, ELIZABETH M.
AU - TRUMP, BENJAMIN F.
T1 - Interindividual Variation in Binding of Benzo[a]pyrene to DNA in Cultured Human Bronchi.
JO - Science
JF - Science
Y1 - 1976/12/03/
VL - 194
IS - 4269
M3 - Article
SP - 1067
EP - 1069
SN - 00368075
AB - The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean ± standard error of 34.2 ± 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361234; HARRIS, CURTIS C. 1; AUTRUP, HERMAN 1; CONNOR, ROBERT 2; BARRETT, LUCY A. 3; MCDOWELL, ELIZABETH M. 3; TRUMP, BENJAMIN F. 3; Affiliations: 1: Human Tissue Studies Section, National Cancer Institute, Bethesda, Maryland 20014; 2: Field Studies and Statistics, National Cancer Institute; 3: Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201; Issue Info: 12/ 3/1976, Vol. 194 Issue 4269, p1067; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WAXMAN, SAMUEL
AU - BRUCKNER, HOWARD
AU - BERTINO, J. R.
AU - GOLDIN, ABRAHAM
T1 - Antitumor Drug Interactions: Additional Data.
JO - Science
JF - Science
Y1 - 1976/12/10/
VL - 194
IS - 4270
M3 - Article
SP - 1112
EP - 1116
SN - 00368075
N1 - Accession Number: 85361242; WAXMAN, SAMUEL 1; BRUCKNER, HOWARD 1; BERTINO, J. R. 2; GOLDIN, ABRAHAM 2,3; Affiliations: 1: Cancer Chemotherapy Foundation Laboratory, Division of Medical Oncology, Mount Sinai School of Medicine, City University of New York, New York 10029; 2: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; 3: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 12/10/1976, Vol. 194 Issue 4270, p1112; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Gold, P. W.;
AU - Goodwin, F. K.;
AU - Wehr, T.;
AU - Rebar, R.;
AU - Sack, R.;
T1 - Growth hormone and prolactin response to levodopa in affective illness
CT - Growth hormone and prolactin response to levodopa in affective illness
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/12/11/
VL - 2
IS - Dec 11
SP - 1308
EP - 1309
SN - 00237507
AD - Section on Psychiatry, Lab. of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 14-2335; Language: English; Chemical Name: Levodopa--59-92-7; Therapeutic Class: (28:16); AHFS Class: Psychotherapeutic agents levodopa; References: 11; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Growth hormone and prolactin response to levodopa was assessed in 20 patients with a primary affective disorder and in 10 healthy volunteers. After an overnight fast, all subjects received 500 mg of oral levodopa, and plasma was drawn sequentially over a 3 hr period and analyzed for growth hormone and prolactin. No relationship was found between neuroendocrine responses to levodopa and age. There was no significant difference in growth hormone or prolactin response to levodopa between the whole group of depressed patients and controls. However, the bipolar group had a significantly larger peak growth hormone increment than did unipolar patients (P \LT/ 0.01) or controls (P \LT/ 0.01).
KW - Levodopa--effects-;
KW - Psychotherapeutic agents--levodopa--effects, on growth hormone and prolactin response, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - BERGMANN, FRED H.
T1 - A Bank of Mammalian DNA Fragments.
JO - Science
JF - Science
Y1 - 1976/12/17/
VL - 194
IS - 4271
M3 - Article
SP - 1226
EP - 1226
SN - 00368075
N1 - Accession Number: 85361280; BERGMANN, FRED H. 1; Affiliations: 1: Genetics Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 12/17/1976, Vol. 194 Issue 4271, p1226; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DEVARE, SUSHILKUMAR G.
AU - STEPHENSON, JOHN R.
AU - SARMA, PADMAN S.
AU - AARONSON, STUART A.
AU - CHANDER, SATISH
T1 - Bovine Lymphosarcoma: Development of a Radioimmunologic Technique for Detection of the Etiologic Agent.
JO - Science
JF - Science
Y1 - 1976/12/24/
VL - 194
IS - 4272
M3 - Article
SP - 1428
EP - 1430
SN - 00368075
AB - A highly sensitive and specific radioimmunoassay has been developed for the major structural protein of an oncornavirus etiologically associated with bovine lymphosarcoma. This test can be used to identify cattle which have been exposed to the bovine leukemia virus and may thus develop or transmit the disease. Analysis of randomly obtained serums indicates that infection with this virus is widespread among cattle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361351; DEVARE, SUSHILKUMAR G. 1; STEPHENSON, JOHN R. 1; SARMA, PADMAN S. 1; AARONSON, STUART A. 1; CHANDER, SATISH 2; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; 2: Animal Disease Research Institute, Ottawa, Ontario, Canada K2H 8P9; Issue Info: 12/24/1976, Vol. 194 Issue 4272, p1428; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-18626-000
AN - 9999-18626-000
AU - Martin, William R.
AU - Hewett, Barbara B.
AU - Baker, Alice J.
AU - Haertzen, Charles A.
T1 - Maturation Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1977///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-18626-000. Partial author list: First Author & Affiliation: Martin, William R.; National Institute on Drug Abuse, Addiction Research Center, Division of Research, Lexington, Kentucky, United States. Release Date: 20130408. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: The measure uses a True or False response format.. Language: English. Constructs: Maturity; Personality Traits; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360).
AB - Purpose: The Maturation Scale was designed to measure feeling states and attitudes assumed to be related to antisocial personality: impulsivity, egocentricity, hypophoria, sociopathic feelings and increased needs in drug addiction and alcoholism.
AB - Description: The Maturation Scale (Martin et al., 1977) measures immaturity and current existing feeling states and attitudes that are presumed to be related to antisocial personality. This questionnaire is adapted from a list of 347 items related to impulsivity, egocentricity, hypophoria, sociopathic feelings, and increased needs accumulated from the Addiction Research Center Inventory (ARCI), the Minnesota Multiphasic Personality Inventory (MMPI) and the California Psychological Inventory (CPI), which were related to psychopathy, mania, irresponsibility, popularity, social withdrawal and antisocial feelings. Hypochondriacal, Depression and Opiate Withdrawal Scale items which could be conceived as related to hypophoria were not selected. The resulting questionnaire consists of 67 items classified into five categories: impulsivity, egocentricity, needs-basic needs, hypophoria-depression and sociopathy. The Egocentricity subscale (7 items) contains items related to selfishness, inability to love, and callousness. The Impulsivity subscale (6 items) measures thoughtlessness and uninhibited behavior. The Need subscale (11 items) assess sexual desire, hunger, body health, pain, and general wanting. The Hypophoria subscale (27 items) measures a general negative perception of life, poor self-image, feelings of being disrespected, disapproved of and unappreciated, and feelings of inefficiency or ineptness, withdrawal from competition, worry, and anger. The Sociopathy subscale (16 items) assess antisocial feelings, feelings of noncomformity, poor judgment, and lack of social concern. Respondents are asked their level of agreement 'according to the way you feel today.' Using male prisoners, alcoholics, faculty and students of a college and theologic seminary in the sample, the data suggests the validity of the Maturation Scale has been only partially validated. Egocentricity, Need, Hypophoria and Sociopathy subscale scores are correlated with Maturation Scale scores for all groups of subjects. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Egocentricity Subscale
KW - Hypophoria Subscale
KW - Impulsivity Subscale
KW - Maturation Scale
KW - Need Subscale
KW - Sociopathy Subscale
KW - Test Development
KW - Validity
U5 - Maturation Scale [Test Development]Aspects of the psychopathology and pathophysiology of addiction. (AN: 1978-10093-001 from PsycINFO) Martin, William R.; Hewett, Barbara B.; Baker, Alice J.; Haertzen, Charles A.; May, 1977. Source: Drug and Alcohol Dependence. 2(3), Elsevier Science, Netherlands; May, 1977; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Location: United States; Sample: Prisoners (Ages 27-50); Alcoholics (Ages 22-54); College Faculty/Students (Ages 22-55) Keywords: Egocentricity Subscale; Hypophoria Subscale; Impulsivity Subscale; Maturation Scale; Need Subscale; Sociopathy Subscale; Test Development; Validity; Subjects: Antisocial Behavior; Egocentrism; Emotional Maturity; Human Development; Impulsiveness; Needs; Rating Scales; Test Construction; Test Validity;
DO - 10.1037/t18626-000
L3 - Full; Full text; 999918626_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Anders, E. Margot
AU - McAdam, K. P. W. J.
AU - Anders, R. F.
T1 - Cell-mediated immunity in amyloidosis secondary to lepromatous leprosy.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/01//
VL - 27
IS - 1
M3 - Article
SP - 111
EP - 117
PB - Wiley-Blackwell
SN - 00099104
AB - Cell-mediated immunity in lepromatous leprosy patients with and without amyloidosis has been studied. Amyloidosis occurred mostly in patients with a history of recurrent erythema nodosum leprosum (ENL) reactions. For this reason, two control groups of leprosy patients were included, one having a history of recurrent ENL and the other little or no ENL. The lack of responsiveness to lepromin in vivo and in vitro, characteristic of lepromatous leprosy, was not altered by the presence of amyloidosis or a history of ENL. No significant difference between the patient groups was observed in the response to PPD in vitro, but skin reactivity to PPD was significantly lower in the patients with amyloidosis than in those without amyloidosis. In contrast, the PHA responses of patients with amyloidosis were significantly higher than those of control patients without a history of ENL, but not significantly different from those of control patients with a history of recurrent ENL. Lepromatous leprosy patients who develop amyloidosis thus appear to belong to a group, susceptible to repeated attacks of ENL, whose PHA responses are higher than those of other lepromatous leprosy patients. The lower skin reactivity to PPD observed in the amyloid group may reflect a general impairment in delayed cutaneous hypersensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNITY
KW - LEPROSY
KW - AMYLOIDOSIS
KW - ERYTHEMA
KW - GLYCOPROTEINS
KW - LYMPHOPROLIFERATIVE disorders
N1 - Accession Number: 16029297; Anders, E. Margot 1,2 McAdam, K. P. W. J. 1,3 Anders, R. F. 1,4; Affiliation: 1: Faculty of Medicine, University of Papua New Guinea, Port Moresby and Institute of Medical Research, Goroka, Papua New Guinea 2: Department of Microbiology, University of Melbourne, Parkville, Victoria 3052, Australia. 3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014, U.S.A. 4: Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.; Source Info: Jan1977, Vol. 27 Issue 1, p111; Subject Term: IMMUNITY; Subject Term: LEPROSY; Subject Term: AMYLOIDOSIS; Subject Term: ERYTHEMA; Subject Term: GLYCOPROTEINS; Subject Term: LYMPHOPROLIFERATIVE disorders; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Bachur, N. R.;
AU - Riggs, C. E.;
AU - Green, M. R.;
AU - Langone, J. J.;
AU - Van Vunakis, H.;
AU - \ET/;
T1 - Plasma adriamycin and daunorubicin levels by fluorescence and radioimmunoassay
CT - Plasma adriamycin and daunorubicin levels by fluorescence and radioimmunoassay
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1977/01/01/
VL - 21
IS - Jan
SP - 70
EP - 77
SN - 00099236
AD - Reprints: Lab. of Clinical Biochemistry, Baltimore Cancer Research Center, NCI, 3100 Wyman Park Dr., Baltimore, Maryland 21221
AD - Lab. of Clinical Biochemistry, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, and; Graduate Dept. of Biochemistry, Brandeis Univ., Waltham, Massachusetts
N1 - Accession Number: 14-5987; Language: English; Trade Name: Daunomycin--Adriamycin; Generic Name: Daunorubicin; Doxorubicin; Chemical Name: Daunorubicin--20830-81-3 Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 13; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2 - The pharmacokinetics of daunomycin (daunorubicin; I) and adriamycin (doxorubicin; II) were followed by fluorescence and radioimmunoassay in 25 and 4 patients, respectively. Patients received between 25-100 micromole/sq m of II or 171-308 micromole/sq m of I. The drugs were administered IV and blood samples were assayed immediately before and at appropriate times after drug injection. The plasma drug decay followed first order kinetics in a triphasic pattern. Both assays showed similar decay up to 4 hr but diverged at that point with the fluorescence assay yielding higher values. Pharmacokinetic differences were amplified in patients with liver dysfunction. The radioimmunoassay offered the capability to measure II and I in clinical settings in which fluorescence assay was not available.
KW - Daunorubicin--pharmacokinetics-;
KW - Doxorubicin--pharmacokinetics-;
KW - Pharmacokinetics--daunorubicin--blood levels, first order kinetics, fluorescence, radioimmunoassay, patients;
KW - Pharmacokinetics--doxorubicin--blood levels, first order kinetics, fluorescence, radioimmunoassay, patients;
KW - Blood levels--daunorubicin--pharmacokinetics, fluorescence, radioimmunoassay, patients;
KW - Blood levels--doxorubicin--pharmacokinetics, fluorescence, radioimmunoassay, patients;
KW - Fluorometry--daunorubicin--comparison, radioimmunoassay, blood levels, patients;
KW - Fluorometry--doxorubicin--comparison, radioimmunoassay, blood levels, patients;
KW - Radioimmunoassay--daunorubicin--comparison, fluorometry, blood levels, patients;
KW - Radioimmunoassay--doxorubicin--comparison, fluorometry, blood levels, patients;
KW - Antineoplastic agents--daunorubicin--pharmacokinetics, patients;
KW - Antineoplastic agents--doxorubicin--pharmacokinetics, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Schneider, John H
T1 - Design, implementation, and management of a comprehensive system of information services for cancer researchers
JO - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
JF - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
Y1 - 1977///
M3 - Book
AB - Steps leadings to the establishment of the international cancer research data bank (icrdb) program and its production of a wide variety of useful information services and products for cancer researchers are described. The following major icrdb program activities are outlined: 1) establishment of rapidly growing on-line information services, collectively referred to as cancerline. Four data bases (cancerlit, cancerproj, clinprot, and cancercite) which make up the cancerline system are discussed; 2) production and distribution of publications for cancer researchers. A growing series of current awareness publications called cancergrams and series of 'special listings' containing descriptions of current cancer research projects are described; 3) a number of other information services, products, and related activities are also mentioned.
N1 - Accession Number: ISTA1301162; Schneider, John H 1; Affiliations: 1 : International Cancer Research Data Bank Program, Office Of International Affairs, National Cancer Institute, Bethesda, Maryland.; Source Info: 1977; Note: Update Code: 1300; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Cherry, J. D.;
AU - McIntosh, K.;
AU - Connor, J. D.;
AU - Benenson, A. S.;
AU - Alling, D. W.;
AU - \ET/;
T1 - Primary percutaneous vaccination
CT - Primary percutaneous vaccination
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1977/01/01/
VL - 135
IS - Jan
SP - 145
EP - 154
SN - 00221899
AD - Infect. Dis. Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31, Room 7A-10, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-3165; Language: English; References: 22; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - In an investigation of the antigenicity and reactogenicity of 4 smallpox vaccines, 786 children received primary percutaneous vaccination with vaccine in one of 3 concentrations, 10\SU/6\BS/,10\SU/7\BS/,10\SU/8\BS/ pock forming units/ml. Dose response curves indicated that the 3 licensed vaccines (New York City Board of Health strains grown in calf lymph or chorioallantoic membrane, and the Lister vaccine) had similar potencies, but the CV-1 strain was about 10-fold less infections. CV-1 also produced smaller skin lesions than the other 3 vaccines, and the incidence of fever in CV-1 vaccines who developed either major reactions or serum antibody was not significantly different from that in children in all vaccine groups with no evidence of take. Hemagglutination-inhibiting antibody was consistently seen in individuals who received potent New York City and Lister vaccines, and neutralizing antibody was induced in 82-85% of children in this group who had some evidence of take (production of hemagglutination-inhibiting antibody or major reaction). Only 30% of CV-1 vaccines with takes produced neutralizing antibody. Minor complications occurred in all groups, but most often in children who received the New York City strains.
KW - Smallpox vaccines--immunization--primary, percutaneous, 3 strains compared, children;
KW - Immunization--smallpox--vaccines, primary, percutaneous, 3 strains compared, children;
KW - Toxicity--smallpox vaccines--side effects, percutaneous, 3 strains compared, children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - McIntosh, K.;
AU - Cherry, J. D.;
AU - Benenson, A. S.;
AU - Connor, J. D.;
AU - Alling, D. W.;
AU - \ET/;
T1 - Standard percutaneous vaccination of children who received primary percutaneous vaccination
CT - Standard percutaneous vaccination of children who received primary percutaneous vaccination
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1977/01/01/
VL - 135
IS - Jan
SP - 155
EP - 166
SN - 00221899
AD - Infectious Diseases Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31, Room 7A-10, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-3169; Language: English; References: 16; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations; Pharmacology
N2 - A standard challenge with percutaneous smallpox vaccine was administered to 629 children 6 to 12 months after percutaneous primary inoculation with one of 4 vaccines. Of those who had had major reactions on primary vaccination, 8-21% responded to revaccination with a typical primary type skin response. In contrast, such a primary type response occurred in 50% of those who on primary vaccination had developed serum antibody in the absence of major reactions and in 83% of those who had had no serologic or clinical evidence of primary take. Skin lesions on revaccination tended to be largest in those whose primary vaccination was with CV-1, although fever and minor complication were not more frequent. Moreover, even in children who had received CV-1 vaccine, skin responses to challenge vaccine were clearly attenuated when compared with responses of children who had not had takes on primary vaccination. Sizes of lesions and acceleration of skin erythema after challenge were related in most children to titers of both hemagglutination-inhibiting and neutralizing antibody at the time of revaccination.
KW - Smallpox vaccines--immunization--reactions, children;
KW - Immunization--smallpox--vaccines, challenge, reactions, children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cherry, J. D.;
AU - Connor, J. D.;
AU - McIntosh, K.;
AU - Benenson, A. S.;
AU - Alling, D. W.;
AU - \ET/;
T1 - Standard percutaneous revaccination of children who received primary subcutaneous vaccination
CT - Standard percutaneous revaccination of children who received primary subcutaneous vaccination
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1977/01/01/
VL - 135
IS - Jan
SP - 176
EP - 182
SN - 00221899
AD - Infectious Diseases Branch, National Institute of Allergy and Infectious Diseases, Bldg. 31 Room 7A-10, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-3168; Language: English; References: 17; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Six months after SC vaccination with one of 4 smallpox vaccines, 665 children were challenged with a standard percutaneous smallpox vaccine. Response to reimmunization was characterized by a significant acceleration and diminution of skin response, but not to the degree seen in an equivalent group who had received their primary immunization percutaneously. Fever after revaccination was absent if there had been a take with primary SC vaccination. The overall incidence of minor vaccine related complications with revaccination was 2.5%. The neutralizing antibody response to revaccination was markedly reduced, as compared to that of children who received either one or 2 successful percutaneous vaccinations. SC vaccination followed by percutaneous vaccination is not recommended as a schedule for smallpox immunization, because complications are not avoided, and the incidence and mean titer of resultant neutralizing antibody are low.
KW - Smallpox vaccines--percutaneous--following SC vaccination, evaluations, children;
KW - Immunization--smallpox--vaccines, percutaneous, following SC vaccination, evaluations, children;
KW - Drug administration--routes--smallpox vaccines, percutaneous, following SC, evaluations, children;
KW - Rational therapy--smallpox vaccines--percutaneous, following SC, evaluations, children;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Feldmann, R J
AU - Heller, S.r.
T1 - A computer-based chemical information system
JO - Science 195(4275), 253-259 (1977 January 21). 27 Ref
JF - Science 195(4275), 253-259 (1977 January 21). 27 Ref
Y1 - 1977///
M3 - Book Chapter
AB - A description is presented of the real-time on-line internationally accessible chemical information system (cis) under development by cooperation between nih and epa. (not to be confused with the identical acronym referring to congressional information service). Numerical and bibliographic data included so far in the nih-epa system, based on the use of a pdp-10 resident computer plus several software packages, are mass spectra, carbon-13 nuclear magnetic resonance (nmr) spectra, and x-ray diffraction (crystallographic) spectra. In addition, interactive program packages are available for performing various mathematical operations on user-supplied data; for determining isotopic label incorporation (labdet); for conformational analysis of molecules in solution (camseq); for performing substructure searches (sss); and so forth. Reasonable search costs are claimed as one major advantage of the developing system.
N1 - Accession Number: ISTA1202432; Feldmann, R J 1; Heller, S.r. 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Maryland; Source Info: 1977; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Isaacs, Leslie Dashew
T1 - Art-Therapy Group for Latency Age Children.
JO - Social Work
JF - Social Work
Y1 - 1977/01//
VL - 22
IS - 1
M3 - Article
SP - 57
PB - Oxford University Press / USA
SN - 00378046
AB - The article focuses on the usefulness of art therapy in treating latency age children who had problems with peer relationships. It presents a review of the literature pertaining to art therapy and child group therapy, which shows no precedent for group art therapy with children. It depicts the goals of art-therapy group, which were both diagnostic and therapeutic. It was anticipated that the sharing of art materials, the process of producing artwork, and the discussion of the production would facilitate the group process. The group was composed of four girls between the ages of nine and eleven. Two girls dropped out after the first six weeks and two other girls later joined. From its first session the group demonstrated its value in attaining both the diagnostic and treatment goals. The article states that as the group progressed the artwork became less important. The girls found other means of interacting, as they become more comfortable sharing feelings, thoughts, and experiences verbally. Thus, the art-therapy group for latency age girls was found to be an excellent diagnostic tool in demonstrating the particular behavior that led to each child's peer-related problems.
KW - ART therapy
KW - GROUP psychotherapy
KW - PEERS
KW - INTERPERSONAL relations
KW - CHILDREN
KW - PSYCHOTHERAPY
N1 - Accession Number: 5268951; Isaacs, Leslie Dashew 1; Affiliation: 1: Assistant to Coordinator, Primary Prevention Programs, National Institute of Mental Health, Rockville, Md.; Source Info: Jan77, Vol. 22 Issue 1, p57; Subject Term: ART therapy; Subject Term: GROUP psychotherapy; Subject Term: PEERS; Subject Term: INTERPERSONAL relations; Subject Term: CHILDREN; Subject Term: PSYCHOTHERAPY; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-05428-001
AN - 2009-05428-001
AU - Torrey, E. Fuller
T1 - On the sociology of lost ideas in schizophrenia research and the watering of gardens.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1977///
VL - 3
IS - 2
SP - 176
EP - 178
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-05428-001. PMID: 887900 Partial author list: First Author & Affiliation: Torrey, E. Fuller; Center for Studies of Schizophrenia, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Schizophrenia; Trends. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1977.
AB - Just as there are fashions in etiquette, sexual mores, and dress styles in our culture, so there are also fashions in schizophrenia research. Some research ideas are in fashion, while others are considered unfashionable or old fashioned. One consequence of these fashions is that potentially valuable research ideas get discarded for years at a time. There is a sociology of lost ideas in our research field, and probably in all research fields. There are certain ideas which are socially acceptable within the research community and others which are not acceptable. Acceptability is only partly determined by objective evidence or evaluation of the idea. Several suggestions are made for addressing this situation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia research
KW - ideas
KW - trends
KW - 1977
KW - Experimentation
KW - Schizophrenia
KW - Trends
KW - 1977
DO - 10.1093/schbul/3.2.176
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05428-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09713-003
AN - 2005-09713-003
AU - Durell, Jack
AU - Katz, Martin M.
T1 - Introduction to the Issue: The Changing Clinical Picture of Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1977///
VL - 3
IS - 4
SP - 528
EP - 530
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2005-09713-003. PMID: 594682 Partial author list: First Author & Affiliation: Durell, Jack; Psychiatric Institute, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20060306. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Schizophrenia. Minor Descriptor: Deinstitutionalization; Drug Therapy. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1977.
AB - Two years ago, at a meeting of the Bulletin's Editorial Board, it was decided to publish an issue devoted to the clinical phenomenology of schizophrenia. The emphasis was to be placed not on static descriptive material but rather on the changes in symptoms and clinical course that appear to have occurred over the past 75 years. It seemed reasonable to expect that the major developments in the treatment of schizophrenia would have had a significant impact on its clinical course; psychotropic drugs and 'deinstitutionalization' to cite the most obvious factors. Moreover, many clinicians had reported their impressions of changes in the clinical phenomenology of schizophrenia; e.g., the virtual disappearance of the catatonic subtype. It was not clear, however, whether it was possible to document more precisely what changes had occurred, and whether it was possible to relate the changes to specific causative factors. Nor was it clear to what degree the impression of change was the result of a changing observational vantage point. The manuscripts collected herein are intended to provide a perspective on this complex issue. Unfortunately, there is not even general agreement as to what schizophrenia is today, no less what it was in 1900. Nevertheless, some general agreement emerges that there has been a gradual change in the course of the disorder as well as a gradual change in the observer, and perhaps a more abrupt change in societal management of the schizophrenic. The complex interrelationships of these variables become apparent as one reads the manuscripts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical phenomenology
KW - psychotropic drugs
KW - schizophrenia
KW - deinstitutionalization
KW - observers' perspectives
KW - 1977
KW - Schizophrenia
KW - Deinstitutionalization
KW - Drug Therapy
KW - 1977
DO - 10.1093/schbul/3.4.528
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09713-010
AN - 2005-09713-010
AU - Bartko, John J.
AU - Carpenter, William T. Jr.
T1 - The masks of insanity: A graphics tool for the summarization of psychiatric data.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1977///
VL - 3
IS - 4
SP - 632
EP - 637
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Bartko, John J., NIMH, Bldg. 36, Rm. 1D24, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1 - Accession Number: 2005-09713-010. PMID: 339333 Partial author list: First Author & Affiliation: Bartko, John J.; Division of Biometry and Epidemiology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20060306. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Computer Applications; Face (Anatomy); Graphical Displays; Mental Disorders; Psychiatric Symptoms. Minor Descriptor: Data Collection; Facial Features; Psychopathology; Statistical Analysis. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1977.
AB - This article discusses visual presentation of sign and symptom data. By using graphic techniques to communicate precise data visually, the observer will be able to grasp the concept and the specific information simultaneously. A profile of psychopathologic dimensions is most often presented in terms of a plot, a device for easing the reader's absorption of a great deal of material. The most common statistical graphics device used to summarize a patient's symptom profile is a data plot in the two-dimensional rectangular coordinate system. Statistical graphics is not a new technique, but, when used in conjunction with computer technology, it may provide a promising tool for data display in psychiatric settings. Computers can be programmed to provide various forms of graphics, including humanoid forms. Both the standard two-dimensional rectangular coordinate system profile plot and the face convey the same information. Today's reader is surely familiar with profile plots, but how is the facial expression to be interpreted? A graphics face contrasted to the rectangular coordinate profile plot may facilitate the comprehension of differences as well as similarities among patients and patient groups. Incorporating mnemonic devices between facial features and psychopathologic dimensions will aid in this regard. Such facial representations of psychiatric data may have a place in clinical records. As the clinician learns to read the face in terms of the correspondence between facial features and symptom dimensions, this graphics device may serve as a quick refresher of the clinical state/impression of the patient, not to mention its usefulness in following the course of illness over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric data
KW - clinical data
KW - psychopathology
KW - facial features
KW - graphics tool
KW - statistical graphics
KW - 1977
KW - Computer Applications
KW - Face (Anatomy)
KW - Graphical Displays
KW - Mental Disorders
KW - Psychiatric Symptoms
KW - Data Collection
KW - Facial Features
KW - Psychopathology
KW - Statistical Analysis
KW - 1977
DO - 10.1093/schbul/3.4.632
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09713-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - QUENZER, L. F.
AU - GALLI, C. L.
AU - NEFF, N. H.
T1 - Activation of the Nigrostriatal Dopaminergic Pathway by Injection of Cholera Enterotoxin into the Substantia Nigra.
JO - Science
JF - Science
Y1 - 1977/01/07/
VL - 195
IS - 4273
M3 - Article
SP - 78
EP - 80
SN - 00368075
AB - Twenty-four hours after unilateral injection of cholera enterotoxin into the rat substantia nigra there is an increase, in the striatum on the injected side, of basal adenylate cyclase activity, 3,4-dihydroxyphenylacetic acid, and 3-methoxy4- hy-droxyphenylacetic acid. Moreover, there is an increase of motor activity, and rats tend to circle contralateral to the side of the injection. Injection of cholera enterotoxin into brain nuclei may be a useful procedure for pharmacologically activating selected neuronal systems of brain and for studying the pharmacology of drugs that are suspected of interacting with these systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361399; QUENZER, L. F. 1; GALLI, C. L. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 1/ 7/1977, Vol. 195 Issue 4273, p78; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VARMA, S. D.
AU - MIZUNO, A.
AU - KINOSHITA, J. H.
T1 - Diabetic Cataracts and Flavonoids.
JO - Science
JF - Science
Y1 - 1977/01/14/
VL - 195
IS - 4274
M3 - Article
SP - 205
EP - 206
SN - 00368075
AB - Oral administration of quercitrin, an inhibitor of aldose reductase, leads to a significant decrease in the accumulation of sorbitol in the lens of diabetic Octodon degus. The onset of cataract is effectively delayed when quercitrin is continuously administered. Thus in these diabetic animals, as in galactosemic rats, the use of an effective aldose reductase inhibitor impedes the course of cataract development. These observations support the hypothesis that in diabetes, as in galactosemia, aldose reductase plays a key role in initiating the formation of lens opacity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361447; VARMA, S. D. 1; MIZUNO, A. 1; KINOSHITA, J. H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; Issue Info: 1/14/1977, Vol. 195 Issue 4274, p205; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Heller, S. R.
AU - Milne, G. W. A.
AU - Feldmann, R. J.
T1 - A Computer-Based Chemical Information System.
JO - Science
JF - Science
Y1 - 1977/01/21/
VL - 195
IS - 4275
M3 - Article
SP - 253
EP - 259
SN - 00368075
N1 - Accession Number: 85218262; Heller, S. R. 1; Milne, G. W. A. 2; Feldmann, R. J. 3; Affiliations: 1: Computer specialist, Management, Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; 2: Research chemist, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 3: Computer specialist, Division of Computer Research and Technology, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/21/1977, Vol. 195 Issue 4275, p253; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - POSTON, J. MICHAEL
T1 - Leucine 2,3-Aminomutase: A Cobalamin-Dependent Enzyme Present in Bean Seedlings.
JO - Science
JF - Science
Y1 - 1977/01/21/
VL - 195
IS - 4275
M3 - Article
SP - 301
EP - 302
SN - 00368075
AB - Leucine 2,3-aminomutase has been demonstrated in extracts of bean seedlings. The activity of this enzyme is stimulated by coenzyme B12 and is inhibited by intrinsic factor. The inhibition is removed by the addition of coenzyme B12. This evidence is consistent with the presence of a cobalamin-dependent enzyme in higher plants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218284; POSTON, J. MICHAEL 1; Affiliations: 1: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/21/1977, Vol. 195 Issue 4275, p301; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CARTER, RICHARD
AU - NIJHOUT, MARY M.
T1 - Control of Gamete Formation (Exflagellation) in Malaria Parasites.
JO - Science
JF - Science
Y1 - 1977/01/28/
VL - 195
IS - 4276
M3 - Article
SP - 407
EP - 409
SN - 00368075
AB - The only stages of malaria parasites capable of establishing an infection in a mosquito are the gametocytes that circulate in the blood of the vertebrate host. Within minutes of ingestion by a mosquito the gametocytes transform into mature gametes in the process of "exflagellation." This process is controlled in vitro solely by the change in pH in the blood as it moves from the environment of the circulation to that of the atmosphere, the pH rise being mediated by the fall in carbon dioxide tension as the blood equilibrates with the atmosphere. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218321; CARTER, RICHARD 1; NIJHOUT, MARY M. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 1/28/1977, Vol. 195 Issue 4276, p407; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Rozencweig, M.;
AU - Layard, M.;
AU - Slavik, M.;
AU - Muggia, F. M.;
T1 - Daunomycin induced cardiotoxicity in children and adults
CT - Daunomycin induced cardiotoxicity in children and adults
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1977/02/01/
VL - 62
IS - Feb
SP - 200
EP - 208
SN - 00029343
AD - Investigational Drug Branch, Building 37, Room 6E12, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-3421; Language: English; Trade Name: Daunomycin; Generic Name: Daunorubicin; Chemical Name: Daunorubicin--20830-81-3; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents daunorubicin; References: 25; Journal Coden: AJMEAZ; Human Indicator: Yes; Section Heading: Toxicity
N2 - Reports on 5,613 patients receiving daunomycin (daunorubicin; I) were reviewed for cardiotoxicity. Two distinct patterns of cardiotoxicity were determined, congestive heart failure (cardiomyopathy) and ECG changes. Construction of a dose response curve using the percent incidence of cardiomyopathy versus the total dose of I in mg/sq m revealed a dose response relationship between the total dose of I and the development of cardiomyopathy in children and adults. The ECG changes in children and adults did not show a dose dependent relationship. These ECG changes were present consistently even at lowest dosage levels. The dose response curves constructed enable the clinician to judge the relative risk of developing cardiomyopathy at a given total dose of I.
KW - Daunorubicin--toxicity-;
KW - Toxicity--daunorubicin--studies, cardiac, correlation to dosage, children and adults;
KW - Antineoplastic agents--daunorubicin--toxicity, studies, cardiac, correlation to dosage, children and adults;
KW - Dosage--daunorubicin--correlations, cardiotoxicity, children and adults;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Pevnick, J. S.;
AU - Clark, S. C.;
AU - Griffith, J. D.;
T1 - Therapeutic usefulness of propoxyphene napsylate in narcotic addiction
CT - Therapeutic usefulness of propoxyphene napsylate in narcotic addiction
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1977/02/01/
VL - 34
IS - Feb
SP - 227
EP - 233
AD - Addiction Research Center, National Institute on Drug Abuse, P.O. Box 12390, Lexington, Kentucky 40511
N1 - Accession Number: 14-5530; Language: English; Trade Name: Darvon--Dolene--SK-65--Darvon-N; Generic Name: Propoxyphene; Propoxyphene; Propoxyphene; Propoxyphene napsylate; Chemical Name: Propoxyphene--469-62-5 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 22; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Ronald E. Nagata
N2 - The toxicity that limits the abuse potential of propoxyphene napsylate (Darvon-N; I) also limits its usefulness as a therapeutic agent in treating narcotic addiction as shown in a double blind crossover study with 9 volunteers who received gelatin capsules of I, or propoxyphene HCl (Darvon; Dolene; SK-65), SC morphine sulfate, oral placebo and SC placebo in a random order at weekly intervals. The relative potency of I in producing miosis, morphine like subjective effects and euphoria in man was determined. Oral I, 50 to 60 mg, is equivalent to 1 mg of SC morphine.
KW - Propoxyphene--hydrochloride, comparison, napsylate-;
KW - Morphine--dependence-;
KW - Toxicity--propoxyphene--hydrochloride, comparison, napsylate, therapy, narcotic addiction, humans;
KW - Dependence--morphine--therapy, propoxyphene salts, humans;
KW - Analgesics and antipyretics--morphine--dependence, therapy, propoxyphene salts, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tormey, D. C.;
AU - Simon, R.;
AU - Falkson, G.;
AU - Bull, J.;
AU - Band, P.;
AU - \ET/;
T1 - Evaluation of adriamycin and dibromodulcitol in metastatic breast carcinoma
CT - Evaluation of adriamycin and dibromodulcitol in metastatic breast carcinoma
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1977/02/01/
VL - 37
IS - Feb
SP - 529
EP - 534
SN - 00085472
AD - Medical Breast Cancer Section, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-3137; Language: English; Trade Name: Dibromodulcitol--NSC-104800; Generic Name: Mitolactol; Mitolactol; Chemical Name: Doxorubicin--23214-92-8 Mitolactol--10318-26-0; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin and mitolactol (10:00); AHFS Class: Antineoplastic agents mitolactol and doxorubicin; References: 8; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A Phase 1 to 2 evaluation of a combination of adriamycin (doxorubicin; I) and dibromodulcitol (mitolactol; NSC-104800; II) was performed in patients with progressive, metastatic breast carcinoma. All but one patient had been treated previously with chemotherapy. I was given on day one or days one and 8, and II was given on days one to 10 of each 21 to 28 day treatment cycle. Side effects were evaluable in 54 patients, and 50 patients were evaluable for therapeutic response. The dose limiting toxicities were leukopenia and thrombocytopenia. The severity of both toxicities increased as both the I and II doses increased; however, the effect of increases in II dose was much more profound. The mean white blood cell count and platelet nadirs occurred, respectively, on days 15.3 and 15.9; both nadirs were delayed for 0.6 day by each 30 mg/sq m/day increase in the II dose and delayed for 1.7 to 3.9 days using the day one, 8 rather than the day one I schedule. Recovery of the peripheral counts by day 29 was prolonged by the day one, 8, I schedule and by increasing the II dose. A tolerable dose schedule for previously treated patients was considered to be I, 40 mg/sq m on day one, and II, 135 mg/sq m on days one to 10 repeated every 28 days. Responses were observed in 46% (23 of 50) of the patients. There were; one complete remission, 19 partial remissions, and 3 improvements. Thirteen patients showed no change and 14 developed progressive disease. There were responses in 13 of 37 (36%) with visceral dominant disease as compared to 7 of 8 (87%) with osseous and 3 of 5 (60%) with soft tissue dominant disease. There were 22 of 48 (46%) responses in patients previously exposed to alkylating agent therapy. Twenty-two patients had responded and 19 had failed to respond to prior alkylating agent containing regimens; the response rates to II in these groups were, respectively, 45 and 42%. The median time to remission was 29 days. The median time to therapeutic failure was 5.1 months for responders, 2.3 months for patients with no change, and 29 days for progressors. The combination of I and II appears to be an active and well tolerated program in patients with previously treated metastatic breast carcinoma.
KW - Doxorubicin--and mitolactol-;
KW - Mitolactol--and doxorubicin-;
KW - Antineoplastic agents--doxorubicin and mitolactol--carcinomas, metastatic breast, dosage, side effects, and therapy, patients;
KW - Antineoplastic agents--mitolactol and doxorubicin--carcinomas, metastatic breast, dosage, side effects, and therapy, patients;
KW - Combined therapy--doxorubicin and mitolactol--carcinomas, metastatic breast, dosage, and side effects, patients;
KW - Combined therapy--mitolactol and doxorubicin--carcinomas, metastatic breast, dosage, and side effects, patients;
KW - Dosage--doxorubicin and mitolactol--carcinomas, metastatic breast, therapy, and side effects, patients;
KW - Dosage--mitolactol and doxorubicin--carcinomas, metastatic breast, therapy, and side effects, patients;
KW - Toxicity--doxorubicin and mitolactol--side effects, metastatic breast carcinoma, dosage, and therapy, patients;
KW - Toxicity--mitolactol and doxorubicin--side effects, metastatic breast carcinoma, dosage, and therapy, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Straus, M. J.;
AU - Straus, S. E.;
AU - Batiste, L.;
AU - Krezoski, S.;
T1 - Uptake, excretion, and radiation hazards of tritiated thymidine in humans
CT - Uptake, excretion, and radiation hazards of tritiated thymidine in humans
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1977/02/01/
VL - 37
IS - Feb
SP - 610
EP - 618
SN - 00085472
AD - Cell Kinetics Lab., National Cancer Institute-V.A. Hospital, Washington, D.C. 20422
N1 - Accession Number: 14-3331; Language: English; Chemical Name: Thymidine--50-89-5; Therapeutic Class: (78:00); AHFS Class: Radiopharmaceuticals thymidine; References: 43; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - Nine patients with malignant disease were given IV tritiated thymidine (I), 0.2 mCi/kg, for tumor cell kinetics studies. Serial plasma, urine, saliva, and air vapor samples were collected variously for up to 79 days, and tritium activity was measured. The initial half-life of plasma activity was rapid. After one day, the activity decayed with a half-life of 10.8 days, indicating equilibration of activity with the total body water. Urine activity was over 100 times the plasma activity within one hr, with equilibration approaching the plasma activity after 2 days, and then decayed at a similar rate. Saliva and air vapor activity increased to plasma levels and then decayed at the same rate as did plasma activity. In the first 24 hr, approximately 33% of the total injected activity was excreted in the urine. During the first 12 days there were 54.2% urinary and 10.6% insensible losses. Maximum losses determined by extrapolation of observed data were 68% urinary and 19.5% insensible losses, or a total of 87.5%. Approximately 7% of the injected activity may represent material initially incorporated into DNA but later metabolized and excreted. The radiation dose from total body water is estimated at 0.69 rad. The estimated dose absorbed by cell nuclei from incorporated material is a maximum of 20.5 rads. These radiation doses would not seem to contraindicate injection of 0.2 mCi/kg tritiated I to patients. Measurements of activity in personnel and room air indicate that the use of such doses is not hazardous if appropriate precautions are followed.
KW - Thymidine--tritiated-;
KW - Pharmacokinetics--thymidine--tritiated, radiation hazards, cancer patients;
KW - Blood levels--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW - Excretion--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW - Saliva levels--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW - Half-life--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW - Radiopharmaceuticals--thymidine--tritiated, pharmacokinetics, radiation hazards, cancer patients;
KW - Toxicity--thymidine--tritiated, radiation hazards, pharmacokinetics, cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Stylos, W. A.
AU - Rose, N. R.
T1 - Splitting of human thyroglobulin IV. THE ANTIGENICITY OF THE PEPSIN--DERIVED FRAGMENTS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/02//
VL - 27
IS - 2
M3 - Article
SP - 245
EP - 253
PB - Wiley-Blackwell
SN - 00099104
AB - Purified human thyroglobulin (Tg) was hydrolysed by pepsin. After completion of hydrolysis the pepsin hydrolysate was passed through a Sephadex G-200 column to remove undigested Tg. Further isolation of the enzymatic fragments was effected by passage through a Sephadex G-75 column. Two discrete fragments, termed pep I and pep I I, were separated. The two fragments had sedimentation coefficients of l.0 and 0.6, respectively. These fragments retained antigenic determinants reactive with both hetero- and auto-antibodies to Tg. The larger fragment, pep 1. possessed all antigenic determinants to intact Tg while pep II lacked some determinants. Neither fragment contained novel determinants resulting from proteolytic degradation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROGLOBULIN
KW - PEPSIN
KW - ANTIGENS
KW - DEXTRAN
KW - ION exchange (Chemistry)
KW - ANTIGENIC determinants
N1 - Accession Number: 16075830; Stylos, W. A. 1,2 Rose, N. R. 2,3; Affiliation: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Department of Microbiology, State University of New York, Buffalo, Buffalo, New York, U.S.A. 3: Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, 48201, U.S.A.; Source Info: Feb1977, Vol. 27 Issue 2, p245; Subject Term: THYROGLOBULIN; Subject Term: PEPSIN; Subject Term: ANTIGENS; Subject Term: DEXTRAN; Subject Term: ION exchange (Chemistry); Subject Term: ANTIGENIC determinants; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, C. J.
AU - Thomson, L. A.
AU - Stiles, H. M.
AU - Brewer, C.
AU - Neel, J. V.
AU - Brunelle, J. A.
T1 - Plaque, caries, periodontal diseases, and acculturation among Yanomamö Indians, Venezuela.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1977/02//
VL - 5
IS - 1
M3 - Article
SP - 30
EP - 39
SN - 03015661
AB - The number of DM and d teeth and surfaces was recorded for 220 Yanomamö, Indians front three groups of villages with different degrees of contact with Western culture. Specimens of plaque were taken from the teeth, transported in a holding solution, cultured, and examined for specific oral streptococci. In addition, the periodontal health and oral hygiene of one group of villagers were assessed using the Russell PI and the Greene & vermillion OHIS. Caries experience among the Yanomamö was shown to be positively associated with exposure to Western culture. S. mutans was recovered with about the same frequency from specimens taken from the teeth of Indians living at all three village locations. However, the presence of S. mutans alone did not account for the disparity in dental caries scores. The examinees had abundant and persistent accumulations of soft deposits on teeth accompanied by markedly inflamed gingival tissues. However, periodontal pockets and loss of appreciable amounts of bone did not appear as early in life nor were they as severe as reported for sonic other populations which practice little oral hygiene. Those disparities in the distribution of plaque-induced oral diseases between Western populations and the Yanomamö warrant further study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTAL disease
KW - DENTAL plaque
KW - DENTAL caries
KW - TEETH
KW - ORAL hygiene
KW - STREPTOCOCCUS
KW - GUMS
KW - TISSUES
KW - YANOMAMO (South American people)
KW - VILLAGES
KW - denial caries
KW - dental plaque
KW - Indians
KW - periodontal disease
N1 - Accession Number: 12103459; Donnelly, C. J. 1 Thomson, L. A. 2 Stiles, H. M. 2 Brewer, C. 3 Neel, J. V. 4 Brunelle, J. A. 2; Affiliation: 1: Johns Hopkini University School of Hygiene and Public Health, Department of Health Services Administration 615 N. Wolfe Street Baltimore, Maryland 21205 U.S.A. 2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014 U.SA. 3: Edificio Galipan Averida Francisco Miranda Caracas Venezuela. 4: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, U.S.A.; Source Info: Feb1977, Vol. 5 Issue 1, p30; Subject Term: PERIODONTAL disease; Subject Term: DENTAL plaque; Subject Term: DENTAL caries; Subject Term: TEETH; Subject Term: ORAL hygiene; Subject Term: STREPTOCOCCUS; Subject Term: GUMS; Subject Term: TISSUES; Subject Term: YANOMAMO (South American people); Subject Term: VILLAGES; Author-Supplied Keyword: denial caries; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: Indians; Author-Supplied Keyword: periodontal disease; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1600-0528.ep12103459
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Krause, R. M.;
T1 - Prevention through immunization: new opportunities or end of the road?
CT - Prevention through immunization: new opportunities or end of the road?
JO - Journal of Infectious Diseases (USA)
JF - Journal of Infectious Diseases (USA)
Y1 - 1977/02/01/
VL - 135
IS - Feb
SP - 318
EP - 329
SN - 00221899
AD - National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland
N1 - Accession Number: 14-5658; Language: English; References: 42; Publication Type: Review; Journal Coden: JIDIAQ; Human Indicator: Yes; Section Heading: Pharmacology; MicrobiologyDrug EvaluationsSociology, Economics and Ethics; Abstract Author: Robert Barger
N2 - This review article discussed the prospects for human immunization for group A streptococcal, gonococcal, pneumococcal and meningococcal infections and immunization with purified bacterial polysaccharide.
KW - Immunization--infections--group A streptococcus, gonococcus, pneumococcus, meningococcus, immunogenetics, polysaccharide capsular vaccines, review, humans;
KW - Vaccines--immunization--infections, group A streptococcus, gonococcus, pneumococcus, meningococcus, immunogenetics, polysaccharide capsular, review, humans;
KW - Polysaccharides--bacterial--vaccines, S. pneumonia, N. meningitis, H. influenza, review, humans;
KW - Gonococcus--infections--immunization, review, humans;
KW - Streptococcus--infections--immunization, review, humans;
KW - Pneumococcus--infections--immunization, review, humans;
KW - Meningococcus--infections--immunization, review, humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rölla, Gunnar
AU - Bowen, William H.
T1 - Concentration of fluoride in plaque--a possible mechanism.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1977/02//Jan/Feb1977
VL - 85
IS - 2
M3 - Article
SP - 149
EP - 151
SN - 0029845X
AB - A mechanism of concentration of fluoride (and phosphate) ions in plaque is suggested: calcium ions from saliva are hound to fixed acidic groups in the plaque, and fluoride (or phosphate) ions are attracted to the bound calcium as counterions. The principle was demonstrated by equilibrium dialysis of calcium-treated acidic ionic exchange material (Sephadex® SP and CM) against 1 part/106 of fluoride. A part of the fluoride was found to be bound under these conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL plaque
KW - DENTAL deposits
KW - FLUORIDES
KW - SALIVA
KW - ORAL microbiology
KW - EXAMINATION
KW - dental plaque
KW - fluorides.
N1 - Accession Number: 13205816; Rölla, Gunnar 1 Bowen, William H. 1; Affiliation: 1: National Caries Program, National institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan/Feb1977, Vol. 85 Issue 2, p149; Subject Term: DENTAL plaque; Subject Term: DENTAL deposits; Subject Term: FLUORIDES; Subject Term: SALIVA; Subject Term: ORAL microbiology; Subject Term: EXAMINATION; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: fluorides.; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-09076-001
AN - 2005-09076-001
AU - Wax, Teena M.
T1 - Effects of Age, Strain, and Illumination Intensity on Activity and Self-Selection of Light-Dark Schedules in Mice.
JF - Journal of Comparative and Physiological Psychology
JO - Journal of Comparative and Physiological Psychology
JA - J Comp Physiol Psychol
Y1 - 1977/02//
VL - 91
IS - 1
SP - 51
EP - 62
CY - US
PB - American Psychological Association
SN - 0021-9940
AD - Wax, Teena M., c/o Charles Goodrick, Gerontology Research Center, NIA, Baltimore City Hospitals, Baltimore, MD, US, 21224
N1 - Accession Number: 2005-09076-001. PMID: 838917 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Wax, Teena M.; University of Delaware and National Institute on Aging, Baltimore, MD, US. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Age Differences; Animal Circadian Rhythms; Animal Strain Differences; Illumination. Minor Descriptor: Mice. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Feb, 1977. Copyright Statement: American Psychological Association. 1977.
AB - Young and senescent albino A/J mice, pigmented C57BL/6J pure inbred mice, and their hybrid F₁s were tested under low or high illumination intensities to observe differences in self-selected wheel running, bar pressing, and durations of light and dark over time. The animals (N=120) were always allowed ad lib access to food, water, running wheel, and bar-press levers. During the pre- and postexperimental phases, the mice were kept under a standard 12:12 hr light/dark cycle; during the experimental phase, however, they were allowed to select their own light and dark schedules by pressing on either of two accessible bars, one light contingent and the other dark contingent. Measures of general running and bar-pressing activities, motivational aspects of illumination change and intensity preferences, timeseries analyses of periodicities, power ratios, and significant other multiples were obtained from the subjects during a total of three experimental phases. Age differences were found for most of the measures studied and in general showed declines in activity levels, increases in motivation to change illumination conditions, lengthening of activity cycles (slower periods), and decreases in the strengths of the oscillations underlying these behaviors as well as an increase in the number of other periodic components in old mice relative to young. Genetic group and illumination-intensity differences were also found, and the results are discussed in light of theories concerning illumination preference and stimulus change, earlier work involving voluntary light selection behavior, and aging studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - age
KW - strain differences
KW - illumination intensities
KW - activity levels
KW - self-selected light-dark schedules
KW - mice
KW - 1977
KW - Activity Level
KW - Age Differences
KW - Animal Circadian Rhythms
KW - Animal Strain Differences
KW - Illumination
KW - Mice
KW - 1977
DO - 10.1037/h0078071
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09076-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06295-014
AN - 2006-06295-014
AU - Plaut, Thomas F. A.
T1 - Humane Health Care: Traditional and Countercultural Approaches.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1977/02//
VL - 22
IS - 2
SP - 117
EP - 119
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06295-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Plaut, Thomas F. A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061226. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Health Care Psychology; Humanism; Nursing; Patients; Health Personnel. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Chapman, Jane E.; Chapman, Harry H. Behavior and Health Care: A Humanistic Helping Process=St. Louis, Mo.: Mosby, 1975. Pp. x + 193. $5.50; 1975. Howard, Jan (Ed); Strauss, Anselm (Ed). Humanizing Health Care=New York: Wiley, 1975. Pp. xiii + 326. $14.95; 1975. Page Count: 3. Issue Publication Date: Feb, 1977.
AB - Reviews the books, Behavior and Health Care: A Humanistic Helping Process by Jane E. Chapman and Harry H. Chapman (1975) and Humanizing Health Care edited by Jan Howard and Anselm Strauss (1975). These two volumes present strikingly different approaches to a single subject--the dehumanization of health care. Humanizing Health Care also includes contributions by medical economists, political scientists, nurses, and social workers. Behavior and Health Care strongly argues for the importance of health care personnel 'taking care' of themselves and not getting trapped by the detachment that often accompanies professional training and increasing emphasis on technical skills. The Howard and Strauss volume is essentially an academic, analytic, research-oriented effort to explore various aspects of dehumanization and possible remedies. The Chapman and Chapman volume, while also relying heavily on social science and psychological concepts, is written primarily for an audience of nursing students and other health care, workers. Chapman and Chapman, in contrast to Howard and Strauss, emphasize the experiential and emotional aspects of the one-to-one face-to-face interaction between healthcare workers and patients. The two volumes highlight contemporary human problems in health care and stress factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavior health care
KW - humanizing health care
KW - healthcare workers
KW - patients
KW - 1977
KW - Health Care Psychology
KW - Humanism
KW - Nursing
KW - Patients
KW - Health Personnel
KW - 1977
U2 - Chapman, Jane E.; Chapman, Harry H. (1975); Behavior and Health Care: A Humanistic Helping Process; St. Louis, Mo.: Mosby, 1975. Pp. x + 193. $5.50
U2 - Howard, Jan (Ed); Strauss, Anselm (Ed). (1975); Humanizing Health Care; New York: Wiley, 1975. Pp. xiii + 326. $14.95
DO - 10.1037/034699
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - EVARTS, EDWARD V.
T1 - Normal Motor Behavior.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 482
EP - 482
SN - 00368075
N1 - Accession Number: 85218354; EVARTS, EDWARD V. 1; Affiliations: 1: Laboratory of Nelurophysiology, National Institute of Mental Health, Bethesda, Maryland; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p482; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SPORN, MICHAEL B.
AU - SQUIRE, ROBERT A.
AU - BROWN, CHARLES C.
AU - SMITH, JOSEPH M.
AU - WENK, MARTIN L.
AU - SPRINGER, STEPHEN
T1 - 13-cis-Retinoic Acid: Inhibition of Bladder Carcinogenesis in the Rat.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 487
EP - 489
SN - 00368075
AB - Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoic acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218358; SPORN, MICHAEL B. 1; SQUIRE, ROBERT A. 1; BROWN, CHARLES C. 1; SMITH, JOSEPH M. 1; WENK, MARTIN L. 2; SPRINGER, STEPHEN 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Microbiological Associates, Bethesda 20014; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p487; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSTEIN, J. N.
AU - YOSHIKAMI, S.
AU - HENKART, P.
AU - BLUMENTHAL, R.
AU - HAGINS, W. A.
T1 - Liposome-Cell Interaction: Transfer and Intracellular Release of a Trapped Fluorescent Marker.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 489
EP - 492
SN - 00368075
AB - When small, unilamellar lipid vesicles containing a high concentration of the fluorescent dye 6-carboxyfluorescein are incubated with either frog retinas or human lymphocytes, fluorescence distributes widely throughout each cell. Since "self-quenching" largely prevents the dye from fluorescing as long as it remains sequestered in vesicles, it is clear that a considerable amount of dye is released from the vesicles and diluted into the much larger volume of the cell [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218359; WEINSTEIN, J. N. 1; YOSHIKAMI, S. 2; HENKART, P. 3; BLUMENTHAL, R.; HAGINS, W. A. 4,5; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health,Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; 3: Immunology Branch, National Cancer Institute; 4: Laboratory of Theoretical Biology, National Cancer Institute; 5: Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p489; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WOOD, JAMES H.
AU - POPLACK, DAVID G.
AU - BLEYER, WERNER A.
AU - OMMAYA, AYUB K.
T1 - Primate Model for Long-Term Study of Intraventricularly or Intrathecally Administered Drugs and Intracranial Pressure.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 499
EP - 501
SN - 00368075
AB - Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinalfluid reservoirs. This model permits sterile access to ventricular cerebrospinalfluid without tissue damage, provides mixing of injected drugs with lateral ventricular cerebrospinal fluid, enables spinoventricular perfusion, and permits ventricular cerebrospinalfluid sampling over extended periods in unanesthetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218364; WOOD, JAMES H. 1; POPLACK, DAVID G. 1; BLEYER, WERNER A. 1; OMMAYA, AYUB K. 1; Affiliations: 1: Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, and Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, and Children's Orthopedic Hospital, Seattle, Washington; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p499; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GALE, K.
AU - GUIDOTTI, A.
AU - COSTA, E.
T1 - Dopamine-Sensitive Adenylate Cyclase: Location in Substantia Nigra.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 503
EP - 505
SN - 00368075
AB - A dopamine-sensitive adenylate cyclase with characteristics similar to those measured in the striatum is present in the rat substantia nigra. Destruction of dopamine cell bodies by intranigral 6-hydroxydopamine application failed to abolish the response of nigral adenvlate cyclase to dopamine. In contrast, brain hemitransection between the striatum and substantia nigra, or a more circumscribed lesion of striatonigral pathways, abolished the dopamine stimulation of adenylate cyclase in the substantia nigra. These results suggest that dopamine receptors within the substantia nigra are not located on dopamine cell bodies but are associated with a pathway, containing raminobutyric acid or substance P, which projectsfromforebrain structures to the substantia nigra. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218366; GALE, K. 1; GUIDOTTI, A. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p503; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JASINSKI, DONALD R.
AU - NUTT, JOHN G.
AU - HAERTZEN, CHARLES A.
AU - GRIFFITH, JOHN D.
AU - BUNNEY, WILLIAM E.
T1 - Lithium: Effects on Subjective Functioning and Morphine-Induced Euphoria.
JO - Science
JF - Science
Y1 - 1977/02/11/
VL - 195
IS - 4278
M3 - Article
SP - 582
EP - 584
SN - 00368075
AB - The therapeutic usefulness of lithium in decreasing the euphoria and other symptoms associated with manic behavior and the hypothesis of a common final mechanism for elevations in mood have led to speculation that lithium may block the euphoria induced by drugs of abuse. In this study, lithium alone was antieuphoric in drug-free opiate addicts and, further, did not block morphine-indu&d euphoria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003171; JASINSKI, DONALD R. 1; NUTT, JOHN G. 1; HAERTZEN, CHARLES A. 1; GRIFFITH, JOHN D. 1; BUNNEY, WILLIAM E. 2; Affiliations: 1: Addiction Research Center, National Institute on Drug Abuse, Lexington, Kenituckv 40511; 2: Adult Psvchiatrv Branch, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/11/1977, Vol. 195 Issue 4278, p582; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLASSEN, LYNELL W.
AU - BUDMAN, DANIEL R.
AU - WILLIAMS, GARY W.
AU - STEINBERG, ALFRED D.
AU - GERBER, N. LYNN
T1 - Ribavirin: Efficacy in the Treatment of Murine Autoimmune Disease.
JO - Science
JF - Science
Y1 - 1977/02/25/
VL - 195
IS - 4280
M3 - Article
SP - 787
EP - 789
SN - 00368075
AB - Ribavirin, a drug with known antiviral activity, was given to mice with established lupus nephritis. Ribavirin was effective in prolonging survival, reducing the titer of antibodies to DNA, and reversing proteinuria. Other antiviral agents were not effective in the dosages used. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218396; KLASSEN, LYNELL W. 1; BUDMAN, DANIEL R. 1; WILLIAMS, GARY W. 1; STEINBERG, ALFRED D. 1; GERBER, N. LYNN 1; Affiliations: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Rehabilitation Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/25/1977, Vol. 195 Issue 4280, p787; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Devanthan, S.;
AU - Channabasavanna, S. M.;
T1 - Controlled clinical study with clobazam\M/a new anxiolytic agent
CT - Controlled clinical study with clobazam\M/a new anxiolytic agent
JO - Curr. Ther. Res. Clin. Exp.
JF - Curr. Ther. Res. Clin. Exp.
Y1 - 1977/03/01/
VL - 21
IS - Mar
SP - 361
EP - 367
AD - National Institute of Mental Health and Neuro-Sciences, Bangalore 27, India
N1 - Accession Number: 15-0313; Language: English; Chemical Name: Clobazam--22316-47-8; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers clobazam; References: 9; Journal Coden: CTCEA9; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - A double blind placebo controlled clinical trial was undertaken with clobazam (I) in 47 patients with anxiety neurosis. I, at a concentration of 30 to 40 mg daily, was found to be significantly better than placebo at all evaluation periods from day 0 to day 29, on the Hamilton Anxiety Rating Scale. On day 29, therapeutic response with I was 100%, being significantly better than placebo.
KW - Clobazam--anxiety-;
KW - Tranquilizers--clobazam--anxiety, therapy, neurotic patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Salokangas, Anneli
AU - Talmadge, Kenneth
AU - Bechtel, Elke
AU - Eppenberger, Urs
AU - Chrambach, Andreas
T1 - Calf-Ovary Protein Kinases Dependent on Adenosine 3′:5′ - Monophosphate.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1977/03//3/1/77
VL - 73
IS - 2
M3 - Article
SP - 401
EP - 409
PB - Wiley-Blackwell
SN - 00142956
AB - High resolving power and quantitative application of polyacrylamide-gel electrophoresis at various pore sizes and electrofocusing provide resolution of a calf-ovarian protein-kinase system at an increased level of magnification, as well as optimal preparative routes. Three protein kinases dependent on adenosine 3′:5′-monophosphate are distinguished by polyacrylamide gel electrophoresis in calf ovarian cytosol. These enzymes which are observed in the pH range 7.5–10.2, appear to be aggregates of a common subunit or monomer. The three kinases are, by the criteria of polyacrylamide gel electrophoresis, distinct from three adenosine-3′:5′-monophosphate-binding proteins found in the calf ovarian system. Analysis by electrofocusing on polyacrylamide gel shows that conventionally purified preparations of the major kinase of cytosol contain an overwhelming majority of contaminant proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLIC adenylic acid
KW - ADENOSINE
KW - PROTEIN kinases
KW - CYCLIN-dependent kinases
KW - POLYACRYLAMIDE gel electrophoresis
KW - CYTOSOL
KW - MONOMERS
KW - ENDOCRINOLOGY
N1 - Accession Number: 13723691; Salokangas, Anneli 1,2 Talmadge, Kenneth 1,2 Bechtel, Elke 1,2 Eppenberger, Urs 1,2 Chrambach, Andreas 1,2; Affiliation: 1: Hormone Laboratory and Experimental Endocrinology, Department of Gynecology, University Clinical Medical School, Basel 2: Reproduction Research Branch, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/77, Vol. 73 Issue 2, p401; Subject Term: CYCLIC adenylic acid; Subject Term: ADENOSINE; Subject Term: PROTEIN kinases; Subject Term: CYCLIN-dependent kinases; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: CYTOSOL; Subject Term: MONOMERS; Subject Term: ENDOCRINOLOGY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sobieszlk, Apolinary
T1 - Ca-Linked Phosphorylation of a Light Chain of Vertebrate Smooth-Muscle Myosin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1977/03//3/1/77
VL - 73
IS - 2
M3 - Article
SP - 477
EP - 483
PB - Wiley-Blackwell
SN - 00142956
AB - In vertebrate smooth muscle actomyosin and myofibrils a myosin light chain of molecular weight about 20000 becomes phosphorylated at the same Ca2+ concentration as required to stimulate the actin-activated ATPase activity of myosin. Further, the degree of phosphorylation in the preparations as well as in various reconstituted actomyosins is proportional to their measured Ca2+ sensitivity. The phosphorylation process is very rapid and is essentially completed before the rise in ATPase activity. The enzyme responsible for the observed myosin phosphorylation is a specific myosin light chain kinase which is routinely co-purified with myosin. This kinase is normally present in actomyosin and its removal together with tropomyosin leads to a complete loss of the actin-activated ATPase activity. It is suggested that the Ca-dependent phosphorylation of the light chain via the light chain kinase represents the initial step in the activation of myosin that leads to contraction. Relaxation is probably effected by an as yet uncharacterised light chain phosphatase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOSIN
KW - ACTOMYOSIN
KW - MUSCLE proteins
KW - MYOSIN antibodies
KW - CHEMICAL reactions
KW - PHOSPHORYLATION
KW - SMOOTH muscle
KW - BENZENE
N1 - Accession Number: 13723827; Sobieszlk, Apolinary 1,2; Affiliation: 1: Department of Molecular Biology, University of Aarhus 2: Section on Molecular Cardiology, Cardiology Branch, National Heart, Lung and Bloob Institute National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA; Source Info: 3/1/77, Vol. 73 Issue 2, p477; Subject Term: MYOSIN; Subject Term: ACTOMYOSIN; Subject Term: MUSCLE proteins; Subject Term: MYOSIN antibodies; Subject Term: CHEMICAL reactions; Subject Term: PHOSPHORYLATION; Subject Term: SMOOTH muscle; Subject Term: BENZENE; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Barrows, Charles H.
T1 - Nutrition and aging: The time has come to move from laboratory research to clinical studies.
JO - Geriatrics
JF - Geriatrics
Y1 - 1977/03//
VL - 32
IS - 3
M3 - Editorial
SP - 39
EP - 41
SN - 0016867X
N1 - Accession Number: 17266246; Barrows, Charles H. 1; Source Information: Mar1977, Vol. 32 Issue 3, p39; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1131
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Gershwin, M.E.
AU - Merchant, B.
AU - Steinberg, A.D.
T1 - The effects of synthetic polymeric agents on immune responses of nude mice.
JO - Immunology
JF - Immunology
Y1 - 1977/03//
VL - 32
IS - 3
M3 - Article
SP - 327
PB - Wiley-Blackwell
SN - 00192805
AB - Investigates the influence of synthetic polymeric agents on the immune responsiveness of congenitally athymic nude mice by determining the effects of in vivo treatment with polynucleotides and polymeric haptenated antigens on splenic theta-bearing cells. Cell responses to thymic dependent and thymic independent antigens; Absence of acquisition of improved T-cell function in nude mice.
KW - IMMUNE response
KW - NUDE mouse
KW - POLYMERS
KW - NUCLEIC acids
N1 - Accession Number: 11161102; Gershwin, M.E. 1,2 Merchant, B. 1,2 Steinberg, A.D. 1,2; Affiliation: 1: Department of Medicine, University of California at Davis 2: Immunology Branch, Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration and the Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Maryland; Source Info: Mar77, Vol. 32 Issue 3, p327; Subject Term: IMMUNE response; Subject Term: NUDE mouse; Subject Term: POLYMERS; Subject Term: NUCLEIC acids; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, Donald G.
AU - Gart, John J.
T1 - A Table of Exact Confidence Limits for Differences and Ratios of Two Proportions and Their Odds Ratios.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1977/03//
VL - 72
IS - 357
M3 - Article
SP - 73
SN - 01621459
AB - A table of exact 95 percent confidence limits for differences and ratios of two proportions and their odds ratio, including one-tailed P values for the Fisher-Irwin exact test, is given for a wide variety of 2 x 2 tables with sample sizes of 20(20)100. The calculations are based on Fisher's [3] conditional theory, and the computer algorithm of Thomas [10 or 11] is used to produce the tables. It is shown how the tables may be used for sample size determination without fixing the power for a given alternative hypothesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - ALGORITHMS
KW - ECONOMICS -- Statistical methods
KW - ECONOMETRICS
KW - CONFIDENCE intervals
KW - RATIO & proportion
KW - SAMPLE size (Statistics)
KW - CONDITIONAL expectations (Mathematics)
KW - DIFFERENCE equations
KW - Comparison of proportions
KW - Con- fidence limits
KW - Fisher-Irwin exact test.
KW - Odds ratios
KW - Sample size determination
KW - Two-by-two tables
N1 - Accession Number: 4606651; Thomas, Donald G. 1; Gart, John J. 2; Affiliations: 1: Mathematical Statistician and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Laudow Building, Room C-318, Bethesda, MD 20014.; 2: Head, Mathematical Statistics and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Laudow Building, Room C-318, Bethesda, MD 20014.; Issue Info: Mar1977, Vol. 72 Issue 357, p73; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: ALGORITHMS; Thesaurus Term: ECONOMICS -- Statistical methods; Thesaurus Term: ECONOMETRICS; Subject Term: CONFIDENCE intervals; Subject Term: RATIO & proportion; Subject Term: SAMPLE size (Statistics); Subject Term: CONDITIONAL expectations (Mathematics); Subject Term: DIFFERENCE equations; Author-Supplied Keyword: Comparison of proportions; Author-Supplied Keyword: Con- fidence limits; Author-Supplied Keyword: Fisher-Irwin exact test.; Author-Supplied Keyword: Odds ratios; Author-Supplied Keyword: Sample size determination; Author-Supplied Keyword: Two-by-two tables; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gillette, James R.
AU - Pohl, Lance R.
T1 - A prospective on covalent binding and toxicity.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 849
EP - 871
SN - 00984108
AB - In this paper are discussed (1) the three general mechanisms by which radioisotopes may be retained in animal tissues long after labeled drugs are administered, (2) ways of differentiating these mechanisms, and (3) possible relationships between the toxic effects of drugs and their metabolism. It is emphasized, however, that studies on the disposition of drugs should be coordinated with toxicity studies in order to make the results of bioavailability and pharmacokinetic studies more meaningful in setting limits for food residues. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456801; Gillette, James R. 1 Pohl, Lance R. 2; Affiliation: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20014 2: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1977, Vol. 2 Issue 4, p849; Number of Pages: 23p; Document Type: Article
L3 - 10.1080/15287397709529484
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thorgeirsson, Snorri S.
AU - Wirth, Peter J.
T1 - Covalent binding of foreign chemicals to tissue macromolecules.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 873
EP - 881
SN - 00984108
AB - In vivo and in vitro covafent binding of foreign chemicals to tissue macromolecules via metabolic activation is described, using the analgesic acetaminophen as an example. Acetaminophen is metabolized through a variety of pathways. The arylating metabolite is formed by a cytochrome P‐450 dependent N‐hydroxylation process. The resulting hydroxamic acid is then conjugated with glutathione, and the resulting conjugate is subsequently excreted as the mercapturic acid in the urine. It is not until the glutathione concentration is reduced to about 20% of the initial concentration that covalent binding of acetaminophen to amino acids of proteins occurs and subsequent liver necrosis is seen. The extent of in vitro binding correlates with treatments that alter hepatic necrosis and in vivo binding, indicating that in vitro binding is a valid index of acetaminophen hepatotoxicity. A simple bacterial test system for detecting chemical carcinogens as mutagens is described. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456802; Thorgeirsson, Snorri S. 1 Wirth, Peter J. 2; Affiliation: 1: Section on Molecular Toxicology, Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Laboratory of Chemical Pharmacology, National Cancer Institute, Building 37, Room 5C‐30, Bethesda, Maryland, 20014 2: Section on Molecular Toxicology, Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Mar1977, Vol. 2 Issue 4, p873; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15287397709529485
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Levy, R. I.;
T1 - What you should know about managing hypertension
CT - What you should know about managing hypertension
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1977/03/01/
VL - 43
IS - Mar
SP - 41
EP - 45
SN - 00030627
AD - National Institutes of Health, Bethesda, Maryland
N1 - Accession Number: 14-4171; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacology; Abstract Author: Walter F. Stanaszek
N2 - The chemotherapeutic management of hypertension is discussed including basic dosage recommendations for antihypertensive regimens and dose ranges for oral diuretics and rauwolfia drugs. Pharmacist involvement in terms of detection, review of medication instructions, reinforcement of physician advice, drug therapy surveillance and refill follow-up programs in the treatment of hypertension is briefly discussed.
KW - Hypotensive agents--therapy--dosage, and role of pharmacists in patient management;
KW - Dosage--hypotensive agents--therapy, and role of pharmacists in patient management;
KW - Pharmacists--hypotensive agents--role, in therapy, and patient management;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06296-039
AN - 2006-06296-039
AU - Usdin, Earl
T1 - Old Wine in a New Bottle.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1977/03//
VL - 22
IS - 3
SP - 210
EP - 211
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06296-039. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Usdin, Earl; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Interactions; Drug Therapy; Drugs; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Simpson, Lance L. (Ed). Drug Treatment of Mental Disorders=New York: Raven Press, 1976. Pp. x + 323. $13.50; 1976. Page Count: 2. Issue Publication Date: Mar, 1977.
AB - Reviews the book, Drug Treatment of Mental Disorders edited by Lance L. Simpson (1976). The book is divided into four sections, three of them devoted to the treatment of mental disorders: psychoses, anxiety, affective disorders. On the positive side, most of the drug chapters have a very useful summary with information on generic and trade names as well as the recommended daily dosage range. On the negative side, most of the drug chapters have very weak sections on metabolism; there are no indications of what metabolites have been found for individual drugs, nor which metabolites are active. The four special topics chapters cover pediatrics, geriatrics, adverse reactions, and drug interactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug treatment
KW - mental disorders
KW - drug interactions
KW - drug psychology
KW - 1977
KW - Drug Interactions
KW - Drug Therapy
KW - Drugs
KW - Mental Disorders
KW - 1977
U2 - Simpson, Lance L. (Ed). (1976); Drug Treatment of Mental Disorders; New York: Raven Press, 1976. Pp. x + 323. $13.50
DO - 10.1037/015810
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - BREM, STEVEN S.
AU - GULLINO, PIETRO M.
AU - MEDINA, DANIEL
T1 - Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia.
JO - Science
JF - Science
Y1 - 1977/03/04/
VL - 195
IS - 4281
M3 - Article
SP - 880
EP - 882
SN - 00368075
AB - Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198863; BREM, STEVEN S. 1; GULLINO, PIETRO M. 1; MEDINA, DANIEL 2; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; 2: Department of Cell Biology, Baylor College of Medicine, Houston, Texas; Issue Info: 3/ 4/1977, Vol. 195 Issue 4281, p880; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TULLY, JOSEPH G.
AU - WHITCOMB, ROBERT F.
AU - CLARK, H FRED
AU - WILLIAMSON, DAVID L.
T1 - Pathogenic Mycoplasmas: Cultivation and Vertebrate Pathogenicity of a New Spiroplasma.
JO - Science
JF - Science
Y1 - 1977/03/04/
VL - 195
IS - 4281
M3 - Article
SP - 892
EP - 894
SN - 00368075
AB - A spiroplasma recovered from allantoic fluids of chick embryos infected with the tick-derived suckling mouse cataract agent was grown in continuous passage on a new artificial culture medium. The cultured organisms inducedtypical ocular and other disease symptoms in susceptible animals, and werereisolated from involved host tissues. Although spiroplasmas have been previously recognized as plant and insect pathogens, this is the first spiroplasma shown to multiply at 37°C and to be pathogenic for vertebrates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198869; TULLY, JOSEPH G. 1; WHITCOMB, ROBERT F. 2; CLARK, H FRED 3; WILLIAMSON, DAVID L. 4; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Plant Protection Institute, Agriculture Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705; 3: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 4: Department of Anatomical Sciences, State University of New York, Stony Brook 11794; Issue Info: 3/ 4/1977, Vol. 195 Issue 4281, p892; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAIL, MITCHELL
T1 - Mass Vaccination: Probability of Three Sudden Deaths.
JO - Science
JF - Science
Y1 - 1977/03/11/
VL - 195
IS - 4282
M3 - Article
SP - 934
EP - 935
SN - 00368075
N1 - Accession Number: 85198886; GAIL, MITCHELL 1; Affiliations: 1: Biometry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/11/1977, Vol. 195 Issue 4282, p934; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SAAVEDRA, JUAN M.
AU - RIBAS, JORGE
AU - SWANN, JOHN
AU - CARPENTER, DAVID O.
T1 - Phenylethanolamine: A New Putative Neurotransmitter in Aplysia.
JO - Science
JF - Science
Y1 - 1977/03/11/
VL - 195
IS - 4282
M3 - Article
SP - 1004
EP - 1006
SN - 00368075
AB - Phenylethanolamine is present in the Aplysia nervous system in concentrations similar to that of octopamine. There are receptors that are very specific for phenylethanolamine, which on different neurons mediate sodium, chlorine, or potassium conductance increase responses. These observations indicate that phenylethanolamine may act as a neurotransmitter in Aplysia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198918; SAAVEDRA, JUAN M. 1; RIBAS, JORGE 2; SWANN, JOHN 2; CARPENTER, DAVID O. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; Issue Info: 3/11/1977, Vol. 195 Issue 4282, p1004; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KEIRANS, JAMES E.
T1 - Rocky Mountain Spotted Fever: Occurrence in Massachusetts.
JO - Science
JF - Science
Y1 - 1977/03/25/
VL - 195
IS - 4284
M3 - Article
SP - 1284
EP - 1284
SN - 00368075
N1 - Accession Number: 85198966; KEIRANS, JAMES E. 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1284; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Paul, William E.
AU - Benacerraf, Baruj
T1 - Functional Specificity of Thymus- Dependent Lymphocytes.
JO - Science
JF - Science
Y1 - 1977/03/25/
VL - 195
IS - 4284
M3 - Article
SP - 1293
EP - 1300
SN - 00368075
N1 - Accession Number: 85198968; Paul, William E. 1; Benacerraf, Baruj 2; Affiliations: 1: Chief of Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Professor of comparative pathology and Chairman of Department of Pathology, Harvard Medical School, Boston, Massachusetts; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1293; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FRELIER, P.
AU - MAYHEW, I. G.
AU - FAYER, R.
AU - LUNDE, M. N.
T1 - Sarcocystosis: A Clinical Outbreak in Dairy Calves.
JO - Science
JF - Science
Y1 - 1977/03/25/
VL - 195
IS - 4284
M3 - Article
SP - 1341
EP - 1342
SN - 00368075
AB - Death and illness in a pen of eight yearling dairy heifers was caused by the protozoan parasite Sarcocystis. All animals had weight loss, weakness, marginal anemia, and elevated serum enzymes. Affected animals had high hemagglutinating antibody titers to Sarcocystis antigen. Affected tissues of the two animals that died demonstrated schizonts and young cysts during pathologic examination. The resident farm dog was shedding Sarcocystis sporocysts and was incriminated as the source of infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198995; FRELIER, P. 1; MAYHEW, I. G. 2; FAYER, R. 3; LUNDE, M. N. 4; Affiliations: 1: Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853; 2: Department of Large Animal Medicine, Obstetrics and Surgery, New York State College of Veterinary Medicine; 3: Animal Parasitology Institute, Animal Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705; 4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1341; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - O'BRIEN, STEPHEN J.
AU - KLEINER, GAIL
AU - OLSON, RUSSELL
AU - SHANNON, JOHN E.
T1 - Enzyme Polymorphisms as Genetic Signatures in Human Cell Cultures.
JO - Science
JF - Science
Y1 - 1977/03/25/
VL - 195
IS - 4284
M3 - Article
SP - 1345
EP - 1348
SN - 00368075
AB - The electrophoretic resolution of seven relatively polymorphic human gene-enzyme systems expressed in tissue culture cells can be used as a sensitive genetic monitor for intraspecific cell contamination. An identical genotype at each of the same allozyme loci provides a 95 percent (or greater) confidence estimate of the identity of two cultured lines, on the basis of the allelic frequencies of the seven enzyme loci in natural populations and in populations of independently derived cultured cells. Of 27 commonly used human cell lines examined, only one of 351 pairwise comparisons proved genetically indistinguishable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198997; O'BRIEN, STEPHEN J. 1; KLEINER, GAIL 1; OLSON, RUSSELL 2; SHANNON, JOHN E. 3; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; 2: Flow Laboratories, Rockville, Maryland 20852; 3: American Type Culture Collection, Rockville, 20852; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1345; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAINER, HAROLD
AU - SARNE, YOSEF
AU - BROWNSTEIN, MICHAEL J.
T1 - Neurophysin Biosynthesis: Conversion of a Putative Precursor During Axonal Transport.
JO - Science
JF - Science
Y1 - 1977/03/25/
VL - 195
IS - 4284
M3 - Article
SP - 1354
EP - 1356
SN - 00368075
AB - [35S] Cysteine injected adjacent to the supraoptic nucleus of the rat is rapidly incorporated into a 20,000-dalton protein that, in time, is converted to a 12,000-dalton labeled protein, neurophysin. This putative precursor of neurophysin appears to be synthesized in the supraoptic nucleus and transformed to neurophysin and related peptides during axonal transport to the neurohypophysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199001; GAINER, HAROLD 1; SARNE, YOSEF 1; BROWNSTEIN, MICHAEL J. 2; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 3/25/1977, Vol. 195 Issue 4284, p1354; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Solon, Jerry A.
T1 - Facing Challenges in Service-Related Research in Aging .
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/04//
VL - 67
IS - 4
M3 - Article
SP - 328
PB - American Public Health Association
SN - 00900036
AB - The article provides an overview of the study report of the authors M. W. Linn, L. Gurel and B. S. Linn about the impact of quality nursing home care on patient outcome of the aged. The study describes a typical immediate connection between research and the service world of the nursing community as research is achieved within the service setting. They have met several challenges during the investigation which include the proper application of quality care, the usage of health status outcome measures, the employment of longitudinal study designs, and the evaluation of a goal attainment model.
KW - NURSING research
KW - NURSING home care
KW - OLDER people -- Home care
KW - GERONTOLOGY
KW - HEALTH status indicators
KW - NURSING services
KW - LINN, M. W.
KW - GUREL, L.
KW - LINN, B. S.
N1 - Accession Number: 5662514; Solon, Jerry A. 1; Affiliation: 1: Program Planning Officer, National Institute on Aging, NIH Building 31-Rm. 4B63, Bethesda, MD 20014; Source Info: Apr1977, Vol. 67 Issue 4, p328; Subject Term: NURSING research; Subject Term: NURSING home care; Subject Term: OLDER people -- Home care; Subject Term: GERONTOLOGY; Subject Term: HEALTH status indicators; Subject Term: NURSING services; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); People: LINN, M. W.; People: GUREL, L.; People: LINN, B. S.; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Adam, E.;
AU - Decker, D. G.;
AU - Herbst, A. L.;
AU - Noller, K. L.;
AU - Tilley, B. C.;
AU - \ET/;
T1 - Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones
CT - Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones
JO - Cancer Research (USA)
JF - Cancer Research (USA)
Y1 - 1977/04/01/
VL - 37
IS - Apr
SP - 1249
EP - 1251
SN - 00085472
AD - Professional and Public Relations Committee, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-4260; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; References: 14; Journal Coden: CNREA8; Human Indicator: Yes; Section Heading: Methodology
N2 - A group has been established under the auspices of the National Institutes of Health in order to study the effects of in utero exposure to diethylstilbestrol and other synthetic estrogen compounds. The study, entitled The DESAD Project, seeks to provide answers concerning the risk to exposed offspring born after 1940 of developing cancer or other medically important conditions, including vaginal adenosis and cervical abnormalities. Each of 4 participating institutions is identifying 500 or more subjects with documented in utero exposure. Exposed daughters of different ages are being examined and followed to determine incidence and natural history of vaginal adenosis and other irregularities.
KW - Diethylstilbestrol--toxicity-;
KW - Toxicity--diethylstilbestrol--studies, gynecological anomalies, following in utero exposure, NIH;
KW - Methodology--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure, NIH;
KW - Placental transfer--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure, NIH;
KW - National Institutes of Health--diethylstilbestrol--toxicity, studies, gynecological anomalies, following in utero exposure;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - KRAKAUER, R. S.
AU - STROBER, W.
AU - RIPPEON, D. L.
AU - WALDMANN, T. A.
T1 - Prevention of Autoimmunity in Experimental Lupus Erythematosus by Soluble Immune Response Suppressor.
JO - Science
JF - Science
Y1 - 1977/04//4/ 1/1977
VL - 196
IS - 4285
M3 - Article
SP - 56
EP - 59
SN - 00368075
AB - Young NZB/W mice, treated with injections of soluble immune response suppressor (SIRS) (supernatant from mouse spleen cells exposed to concanavalin A),showed decreased immunoglobulin levels, less antibody to cell nuclei, less proteinuria, and less renal pathology as compared with NZB/W mice receiving a control preparation. Thus, SIRS administration beginning at an early age appears to be an effective therapy of the autoimmune disease in NZB/W mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199050; KRAKAUER, R. S. 1; STROBER, W. 1; RIPPEON, D. L. 1; WALDMANN, T. A. 1; Affiliations: 1: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/ 1/1977, Vol. 196 Issue 4285, p56; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NICHOLS, W. W.
AU - MURPHY, D. G.
AU - CRISTOFALO, V. J.
AU - TOJI, L. H.
AU - GREENE, A. E.
AU - DWIGHT, S. A.
T1 - Characterization of a New Human Diploid Cell Strain, IMR-90.
JO - Science
JF - Science
Y1 - 1977/04//4/ 1/1977
VL - 196
IS - 4285
M3 - Article
SP - 60
EP - 63
SN - 00368075
AB - A new human diploid fibroblast-like cell line has been established from lung tissue of a female fetus. This has been frozen away in large quantity and characterized for use in research and related purposes. This is the first of a planned series of human cell lines to be established, characterized, and banked in large quantity in support of the National Institute on Aging research and general cell biology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199052; NICHOLS, W. W. 1; MURPHY, D. G. 2; CRISTOFALO, V. J. 3; TOJI, L. H. 4; GREENE, A. E. 4; DWIGHT, S. A. 4; Affiliations: 1: Institute for Medical Research, Camden, New Jersey 08103; 2: National Institute on Aging, Bethesda, Maryland 20014; 3: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 4: Institute for Medical Research; Issue Info: 4/ 1/1977, Vol. 196 Issue 4285, p60; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2013-42024-024
AN - 2013-42024-024
AU - Shore, Milton F.
T1 - Review of Children’s rights and the mental health professions.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1977/04//
VL - 47
IS - 2
SP - 359
EP - 360
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42024-024. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Practice; Decision Making; Mental Health Personnel. Minor Descriptor: Civil Rights; Professionalism; Prosocial Behavior. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Reviewed Item: Koocher, Gerald P. (Ed). Children’s rights and the mental health professions=259 pp. $17.95. John Wiley, New York; 1976. Page Count: 2. Issue Publication Date: Apr, 1977.
AB - Reviews the book, Children's Rights and the Mental Health Professions edited by Gerald P. Koocher (see record [rid]1977-13121-000[/rid]). The most notable contribution made by this book is the interweaving of research results with suggestions for changes in professional practice and policy. In this way, an empirical as well as philosophical and humanitarian basis is set for decision making and program development. The book also makes clear that there are no easy answers to the questions raised, so long as children continue to be seen as their parents' property. This book should be read over and over again and discussed in every class and meeting that deals with the professional functioning of mental health providers. Unfortunately, its high price may make the book prohibitive to many people who should read it. It seems essential that it be reissued in paperback so that students have it readily available. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health professions
KW - professional practice
KW - humanitarian
KW - decision making
KW - children rights
KW - 1977
KW - Clinical Practice
KW - Decision Making
KW - Mental Health Personnel
KW - Civil Rights
KW - Professionalism
KW - Prosocial Behavior
KW - 1977
U2 - Koocher, Gerald P. (Ed). (1976); Children’s rights and the mental health professions; 259 pp. $17.95. John Wiley, New York
DO - 10.1037/h0098773
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LEDER, P.
AU - TIEMEIER, D.
AU - ENQUIST, L.
T1 - EK2 Derivatives of Bacteriophage Lambda Useful in the Cloning of DNA from Higher Organisms: The λgtWES System.
JO - Science
JF - Science
Y1 - 1977/04/08/
VL - 196
IS - 4286
M3 - Article
SP - 175
EP - 177
SN - 00368075
AB - A derivative of bacteriophage λ has been modified and tested together with an appropriate host system to meet the criteria of EK2 biologic containment for cloning DNA from higher organisms. In this report certain of the safety features are summarized and some of the tests carried out to confirm the containment properties of the vector are described. The cloning efficiency of this system, together with available gene purification and hybrid screening technology, indicate that it can be used to clone DNA fragments carrying specific, unique mammalian genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199098; LEDER, P. 1; TIEMEIER, D. 1; ENQUIST, L. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 8/1977, Vol. 196 Issue 4286, p175; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAMER, DEAN H.
T1 - Interbacterial Transfer of Escherichia coli- Drosophila melanogaster Recombinant Plasmids.
JO - Science
JF - Science
Y1 - 1977/04/08/
VL - 196
IS - 4286
M3 - Article
SP - 220
EP - 221
SN - 00368075
AB - Recombinants were constructed between various Escherichia coli plasmids and fragments of Drosophila melanogaster DNA. These recombinant plasmids are nonconjugative, but can be mobilized from one cell to another by conjugative sex factors. Of 47 recombinants studied, 46 were mobilized at approximately the same or slightly lower frequencies than the parental plasmids, whereas one was mobilized 1000 times less efficiently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199118; HAMER, DEAN H. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 8/1977, Vol. 196 Issue 4286, p220; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 84008238
T1 - Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease.
AU - Borer, Jeffrey S.
AU - Bacharach, Stephen L.
AU - Green, Michael V.
AU - Kent, Kenneth M.
AU - Epstein, Stephen E.
AU - Johnston, Gerald S.
AU - Mack, Bonnie
AU - Borer, J S
AU - Bacharach, S L
AU - Green, M V
AU - Kent, K M
AU - Epstein, S E
AU - Johnston, G S
Y1 - 1977/04/14/
N1 - Accession Number: 84008238. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Appraisal of Self-Care Agency Scale; Exercise of Self-Care Agency Scale (ESCA) (Kearney and Fleischer); Global Assessment of Functioning Scale (GAF); Defining Issues Test (DIT) (Rest); Functional Living Index: Cancer (FLIC) (Schipper et al). NLM UID: 0255562.
KW - Radionuclide Imaging -- Methods
KW - Coronary Disease -- Diagnosis
KW - Heart Function Tests -- Methods
KW - Cineangiography -- Methods
KW - Heart Ventricle
KW - Coronary Angiography
KW - Angiography
KW - Cardiac Output
KW - Adult
KW - Female
KW - Angina Pectoris -- Diagnosis
KW - Male
KW - Exertion
KW - Coronary Disease -- Physiopathology
KW - Heart Rate
KW - Angina Pectoris -- Physiopathology
KW - Aged
KW - Coronary Circulation
KW - Middle Age
KW - Heart Ventricle -- Physiopathology
KW - Clinical Assessment Tools
KW - Exercise of Self-Care Agency Scale
KW - Scales
SP - 839
EP - 844
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 296
IS - 15
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - Although coronary angiography defines regions of potential ischemia in patients with coronary-artery disease, accurate assessment of the presence and functional importance of ischemia requires appraisal of regional and global left ventricular function during stress. To perform such assessment, we developed a noninvasive real-time radionuclide cineangiographic procedure permitting continuous monitoring and analysis of left ventricular function during exercise. In 11 patients with coronary disease who had normal regional and global ventricular function at rest, new regions of dysfunction developed during exercise (P less than 0.001), and in 10, global ejection fraction dropped 7 to 47 per cent. Fourteen age-matched normal subjects were studied; during exercise none had regional dysfunction, and each increased global ejection fraction (average increase, 23 +/- 3 per cent [+/-S.E.], P less than 0.001 as compared with patients with coronary disease). Radionuclide cineangiography during exercise permits accurate assessment of the presence and functional severity of ischemic heart disease.
SN - 0028-4793
AD - From the Cardiology Branch, National Heart, Lung, and Blood Institute, the Nuclear Medicine Department, Clinical Center, and the Division of Computer Research and Technology, National Institutes of Health (address reprint requests to Dr. Borer at the Cardiology Branch, Bldg. 10, Rm. 7B–15, National Heart, Lung, and Blood Institute, Bethesda, MD 20014).
U2 - PMID: 846493.
DO - 10.1056/NEJM197704142961503
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - SAKURAGAWA, NORIO
AU - SAKURAGAWA, MACHIKO
AU - KUWABARA, TOICHIRO
AU - PENTCHEV, PETER G.
AU - BARRANGER, JOHN A.
AU - BRADY, ROSCOE O.
T1 - Niemann-Pick Disease Experimental Model: Sphingomyelinase Reduction Induced by AY-9944.
JO - Science
JF - Science
Y1 - 1977/04/15/
VL - 196
IS - 4287
M3 - Article
SP - 317
EP - 319
SN - 00368075
AB - Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199164; SAKURAGAWA, NORIO 1; SAKURAGAWA, MACHIKO 2; KUWABARA, TOICHIRO 2; PENTCHEV, PETER G. 3; BARRANGER, JOHN A. 3; BRADY, ROSCOE O. 3; Affiliations: 1: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke, Bethesda, Maryland 20014; 2: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 3: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke; Issue Info: 4/15/1977, Vol. 196 Issue 4287, p317; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Schooley, R. T.;
AU - Wagley, P. F.;
AU - Lietman, P. S.;
T1 - Edema associated with ibuprofen therapy
CT - Edema associated with ibuprofen therapy
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1977/04/18/
VL - 237
IS - Apr 18
SP - 1716
EP - 1717
AD - Reprints: Lab. of Clinical Investigation, Bldg. 10-Rm. 11S-242, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 21205
AD - The Johns Hopkins Univ. School of Medicine, Baltimore, Maryland
N1 - Accession Number: 14-4350; Language: English; Trade Name: Motrin; Generic Name: Ibuprofen; Chemical Name: Ibuprofen--15687-27-1; References: 8; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2 - A 15 kg weight gain developed in a 71-yr-old male patient during the third week of ibuprofen (Motrin) therapy at a dosage of 400 mg 4 times daily. The edema disappeared with discontinuation of the drug regimen and did not reappear during a subsequent 6 month observation period.
KW - Ibuprofen--adverse reactions-;
KW - Drugs, adverse reactions--ibuprofen--weight gain, patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Rowe, Wallace P.
T1 - Guidelines that do the job.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1977/05//
VL - 33
IS - 5
M3 - Article
SP - 14
EP - 15
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21639130; Rowe, Wallace P. 1; Affiliation: 1: Chief, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, md; Source Info: May1977, Vol. 33 Issue 5, p14; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Morris, D.;
AU - Aisner, J.;
AU - Wiernik, P. H.;
T1 - Horizontal pigmented banding of the nails in association with adriamycin chemotherapy
CT - Horizontal pigmented banding of the nails in association with adriamycin chemotherapy
JO - Cancer Treat. Rep.
JF - Cancer Treat. Rep.
Y1 - 1977/05/01/
VL - 61
IS - May-Jun
SP - 499
EP - 501
AD - Dept. of Surgery, and Baltimore Cancer Research Center, Div. of Cancer Treatment, National Cancer Institute, Univ. of Maryland Hospital, 22 S. Greene St., Baltimore, Maryland 21202
N1 - Accession Number: 14-5506; Language: English; Trade Name: Adriamycin; Generic Name: Doxorubicin; Chemical Name: Doxorubicin--23214-92-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents doxorubicin; References: 18; Publication Type: Letters; Journal Coden: CCYPBY; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Walter Howard
N2 - Horizontal pigmented banding of nails was reported in 7 black patients receiving combination chemotherapy including doxorubicin. These bands usually appeared 6-8 weeks after initiation of chemotherapy, and began to disappear 6-8 weeks after discontinuation of doxorubicin. White patients receiving similar drug combinations did not demonstrate this effect. A possible mechanism of action is proposed.
KW - Doxorubicin--adverse reactions-;
KW - Drugs, adverse reactions--doxorubicin--pigmentation, nail, banding, mechanism of action, black patients;
KW - Mechanism of action--doxorubicin--pigmentation, nail, banding, black patients;
KW - Pharmacogenetics--doxorubicin--pigmentation, nail, banding, black patients;
KW - Antineoplastic agents--doxorubicin--pigmentation, nail, banding, black patients;
KW - Race--doxorubicin--pigmentation, nail, banding, black patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Shapiro, Marvin
T1 - The Choice of Reference Points in Best-Match File Searching.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1977/05//
VL - 20
IS - 5
M3 - Article
SP - 339
EP - 343
SN - 00010782
AB - Improvements to the exhaustive search method of best-match file searching have previously been achieved by doing a preprocessing step involving the calculation of distances from a reference point. This paper discusses the proper choice of reference points and extends the previous algorithm to use more than one reference point. It is shown that reference points should be located outside of data clusters. The results of computer simulations are presented which show that large improvements can be achieved by the proper choice and location of multiple reference points. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALGORITHMS
KW - COMPUTER simulation
KW - ELECTROMECHANICAL analogies
KW - MATHEMATICAL models
KW - SIMULATION methods & models
KW - ARITHMETIC
KW - MODELS & modelmaking
KW - ENGINEERING models
KW - MECHANICS (Physics)
KW - best match
KW - file searching
KW - matching
KW - nearest-neighbor classification
N1 - Accession Number: 5495656; Shapiro, Marvin 1; Affiliation: 1: National Institutes of Health.; Source Info: May77, Vol. 20 Issue 5, p339; Subject Term: ALGORITHMS; Subject Term: COMPUTER simulation; Subject Term: ELECTROMECHANICAL analogies; Subject Term: MATHEMATICAL models; Subject Term: SIMULATION methods & models; Subject Term: ARITHMETIC; Subject Term: MODELS & modelmaking; Subject Term: ENGINEERING models; Subject Term: MECHANICS (Physics); Author-Supplied Keyword: best match; Author-Supplied Keyword: file searching; Author-Supplied Keyword: matching; Author-Supplied Keyword: nearest-neighbor classification; Number of Pages: 5p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1145/359581.359599
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Ward, G.;
T1 - How the pharmacist can help in long-term maintenance of antihypertensive therapy
CT - How the pharmacist can help in long-term maintenance of antihypertensive therapy
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1977/05/01/
VL - NS 17
IS - May
SP - 301
EP - 302
AD - National High Blood Pressure Education Program, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-4912; Language: English; References: 7; Journal Coden: JPHAA3; Section Heading: Pharmaceutical Education; Pharmacy Practice; Abstract Author: James A. Starner
N2 - Various ways in which the pharmacist can help to educate and make patients aware of the importance of therapy for reducing hypertension are presented.
KW - Pharmacists--role--education, hypertensive patients;
KW - Education--patients--hypertension, pharmacist's role;
KW - Patients--education--hypertension, pharmacist's role;
KW - Hypertension--education--patients, pharmacist's role;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mackerer, Carl R.
AU - Saunders, Robert N.
AU - Haettinger, Janet R.
AU - Mehlman, Myron A.
T1 - Assessment of diabetogenic drug activity in the rat: 5,5‐Diphenyl‐2‐thiohydantoin.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1041
EP - 1051
SN - 00984108
AB - The diabetogenic activity of 5,5‐diphenyl‐2‐thiohydantoin (DPTH) via oral administration was assessed in both normal and streptozotocin diabetic rats. Rats were fed powdered chow diet with and without 0.1% (w/w) DPTH. Food consumption and body weight were recorded every other day; whole blood glucose concentrations were determined at the start of the study and at the midpoint. At sacrifice, liver and pancreas were excised and blood samples were collected. Protein and lipid levels were determined in liver; insulin in pancreas; and glucose, insulin, and lipid in blood. DPTH treatment caused decreased food consumption and body weight gain. The drug dose, calculated from the food consumption data, was 76.5 mg/kg/day for the normal rats and 107 mg/kg/day for the diabetic rats. DPTH increased liver weight and liver lipid content in both normal and diabetic rats, and markedly lowered serum triglyceride concentration in normal rats but not in diabetic rats. Serum fatty acid concentration was not altered by DPTH. DPTH produced a significant elevation of blood glucose concentration of the diabetic rats that was not, however, correlated with altered pancreatic insulin concentration. In vitro, DPTH infusion inhibited insulin secretion by the perfused pancreas. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456846; Mackerer, Carl R. 1 Saunders, Robert N. 2 Haettinger, Janet R. 2 Mehlman, Myron A. 3; Affiliation: 1: Pharmacodynamics Section, Department of Biological Research, Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680 2: Department of Biological Research, Searle Laboratories, Chicago, Illinois 3: National Institutes of Health, Bethesda, Maryland; Source Info: May1977, Vol. 2 Issue 5, p1041; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/15287397709529502
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HAYES, RONALD
AU - PRICE, DONALD D.
AU - DUBNER, RONALD
T1 - Naloxone Antagonism as Evidence for Narcotic Mechanisms.
JO - Science
JF - Science
Y1 - 1977/05/06/
VL - 196
IS - 4290
M3 - Article
SP - 600
EP - 600
SN - 00368075
N1 - Accession Number: 85199237; HAYES, RONALD 1; PRICE, DONALD D. 1; DUBNER, RONALD 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/ 6/1977, Vol. 196 Issue 4290, p600; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GILLESPIE, DAVID
T1 - Newly Evolved Repeated DNA Sequences in Primates.
JO - Science
JF - Science
Y1 - 1977/05/20/
VL - 196
IS - 4292
M3 - Article
SP - 889
EP - 891
SN - 00368075
AB - Repeated DNA sequences in primates having identical or nearly identical members and exhibiting unusual phylogenetic specificity were analyzed. They appeared in repeated DNA sequences in each group ofprimates, probably within the last 10 to 15 million years, and are conserved to the same extent as unique DNA sequences. The finding allows a new approach to the construction of evolutionary trees. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436315; GILLESPIE, DAVID 1; Affiliations: 1: Section on Nucleic Acid Hybridization, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 5/20/1977, Vol. 196 Issue 4292, p889; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAKE, C. RAYMOND
AU - ZIEGLER, MICHAEL G.
T1 - Lesch-Nyhan Syndrome: Low Dopamine-β-Hydroxylase-Activity and Diminished Sympathetic Response to Stress and Posture.
JO - Science
JF - Science
Y1 - 1977/05/20/
VL - 196
IS - 4292
M3 - Article
SP - 905
EP - 906
SN - 00368075
AB - Patients with Lesch-Nyhan syndrome with virtually no hypoxanthine phosphoribosyltransferase activity demonstrate significantly low plasma activity of dopamineβ-hydroxylase but normal basal levels of norepinephrine. Under conditions of emotional or postural stress the plasma concentrations ofnorepinephrine in Lesch-Nyhan patients increased less than in a normal population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436325; LAKE, C. RAYMOND 1; ZIEGLER, MICHAEL G. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Pharmacology, University of Texas Medical Center, Galveston 77550; Issue Info: 5/20/1977, Vol. 196 Issue 4292, p905; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHRISTIAN, C. N.
AU - NELSON, P. G.
AU - PEACOCK, J.
AU - NIRENBERG, M.
T1 - Synapse Formation Between Two Clonal Cell Lines.
JO - Science
JF - Science
Y1 - 1977/05/27/
VL - 196
IS - 4293
M3 - Article
SP - 995
EP - 998
SN - 00368075
AB - Clonal neuroblastoma x glioma hybrid cellsfrequentlyformed synapses with clonal mouse striated muscle cells. Clonal myotubes were similar to cultured mouse embryo myotubes with respect to acetylcholine sensitivity and other membrane properties examined. However, acetylcholine sensitivity measurements indicate that acetylcholine receptors of clonal myotubes are distributed more uniformly over the cell surface than the receptors of cultured mouse embryo myotubes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436350; CHRISTIAN, C. N. 1; NELSON, P. G. 1; PEACOCK, J. 2; NIRENBERG, M. 3; Affiliations: 1: Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Neurology, Stanford Medical School, Stanford, California; 3: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health; Issue Info: 5/27/1977, Vol. 196 Issue 4293, p995; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAPOOR, C. L.
AU - KRISHNA, G.
T1 - Hormone-Induced Cyclic Guanosine Monophosphate Secretion from Guinea Pig Pancreatic Lobules.
JO - Science
JF - Science
Y1 - 1977/05/27/
VL - 196
IS - 4293
M3 - Article
SP - 1003
EP - 1005
SN - 00368075
AB - Carbamylcholine (30 μM) increased the concentration of guanosine 3',5'-monophosphate (cyclic GMP) in guinea pig pancreatic lobules about eight- to tenfold over the basal concentration in 30 seconds with a concomitant increase in the rate of amylase secretion. The concentration of cyclic GMP rapidly declined to a plateau value of about 16 percent of the peak level in 10 minutes. Cellular cyclic GMP decreased, mostly because the nucleotide was secreted into the medium; cellular adenosine 3',5'-monophosphate (cyclic AMP), however, did not change, nor was this nucleotide secreted into the medium. An immunocytochemical technique showed that cyclic GMP was distributed in the apical plasmalemma membrane and lumen of the pancreas. Carbamylcholine increased the cyclic GMP fluorescence in the apical plasmalemma membrane within 30 seconds, and in zymogen granules and the plasma membrane in the apical part of acinar cells in 10 minutes. The islets of Langerhans did not show any change in cyclic GMP. Fluorescence of cyclic AMP in pancreatic lobules was not altered by carbamylcholine and was localized along the apical portion of plasmalemma and cytoplasm. Cyclic GMP may thus participate either in the process of exocytosis or in the activation of enzymes secreted from the pancreas. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436363; KAPOOR, C. L. 1; KRISHNA, G. 1; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 5/27/1977, Vol. 196 Issue 4293, p1003; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Young, R. C.;
AU - Lippman, M.;
AU - De Vita, V. T.;
AU - Bull, J.;
AU - Tormey, D.;
T1 - Perspectives in the treatment of breast cancer: 1976
CT - Perspectives in the treatment of breast cancer: 1976
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1977/06/01/
VL - 86
IS - Jun
SP - 784
EP - 798
SN - 00034819
AD - Medicine Branch, National Cancer Institute, Bldg. 10, Rm. 12N-236, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-6478; Language: English; References: 75; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Charles C. Depew
N2 - Surgical and chemotherapeutic advances in the treatment of breast cancer are reviewed. Surgery, radiotherapy, and hormonal therapy for early breast cancer; single agent versus combination chemotherapy in advanced breast cancer; and adjuvant chemotherapy after breast cancer surgery are examined. A discussion is presented in which the results of a prospective randomized trial indicate that the response rate to cyclophosphamide, doxorubicin, and fluorouracil is significantly better than to cyclophosphamide, methotrexate, and fluorouracil. Tables are presented showing the percent response to the different chemotherapeutic agents. Side effects and adverse reactions are also mentioned. The major conclusion is that at this time, combination chemotherapy is superior to single agent chemotherapy in treatment of advanced breast cancer. Examples of ongoing controlled trials after radical mastectomy with prolonged adjuvant therapy in primary breast cancer with positive axillary nodes are presented.
KW - Antineoplastic agents--combined therapy--cancer, breast, review;
KW - Combined therapy--antineoplastic agents--cancer, breast, review;
KW - Rational therapy--antineoplastic agents--cancer, breast, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rozencweig, M.;
AU - Von Hoff, D. D.;
AU - Slavik, M.;
AU - Muggia, F. M.;
T1 - \LC/cis\UC/-Diamminedichloroplatinum II. New anticancer drug
CT - \LC/cis\UC/-Diamminedichloroplatinum II. New anticancer drug
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1977/06/01/
VL - 86
IS - Jun
SP - 803
EP - 812
SN - 00034819
AD - Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bldg. 37, Rm. 6E12, Bethesda, Maryland 20014
N1 - Accession Number: 14-6381; Language: English; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cis-diamminedichloroplatinum; References: 141; Publication Type: Review; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Investigational Drugs; PharmacologyDrug Metabolism and Body Distribution; Abstract Author: Charles C. Depew
N2 - A review of the investigational antitumor agent, cis-diamminedichloroplatinum (I), is presented. I is an inorganic complex formed by a central atom of platinum surrounded by chlorine and ammonia atoms. The mechanism of action remains inconclusive at this time. Pharmacokinetic studies in man indicate an initial half-life of 25-49 min and the secondary half-life of 58-73 hr. In clinical trials, I was administered by either rapid IV infusion or by slow IV drip. A table of the different dosing schedules is presented. The 2 most commonly used schedules are: 50-75 mg/sq m body surface area once every 3 weeks and; 15-20 mg/sq m body surface area daily for 5 consecutive days repeated every 3 or 4 weeks. The antineoplastic activity against testicular, ovarian, bladder, head and neck, and childhood carcinomas of I alone and in combination with other agents is discussed. The major toxicities are gastrointestinal and renal impairment. A reduction of renal impairment may be achieved by mannitol induced diuresis with or without furosemide. Other toxicities include ototoxicity, myelosuppression, and anaphylactoid reactions. The dosage ranges at which these reactions occur are presented. The role of I in the treatment of cancer remains inconclusive at this time.
KW - cis-Diamminedichloroplatinum--cancer-;
KW - Antineoplastic agents--cis-diamminedichloroplatinum--cancer, therapy, half-life, dosage schedules, and side effects, review;
KW - Half-life--cis-diamminedichloroplatinum--cancer, therapy, dosage schedules, and side effects, review;
KW - Dosage schedules--cis-diamminedichloroplatinum--cancer, therapy, half-life, and side effects, review;
KW - Toxicity--cis-diamminedichloroplatinum--side effects, half-life, dosage schedules, and cancer therapy, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Barrett, David E.
AU - Yarrow, Marian Radke
T1 - Prosocial Behavior, Social Inferential Ability, and Assertiveness in Children.
JO - Child Development
JF - Child Development
Y1 - 1977/06//
VL - 48
IS - 2
M3 - Article
SP - 475
EP - 481
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 11233394; Barrett, David E. 1 Yarrow, Marian Radke 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Jun1977, Vol. 48 Issue 2, p475; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1467-8624.ep11233394
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Chapin, Ned
AU - Denning, Peter J.
AU - Rose, Lois A.
AU - Cichelli, Martha J.
AU - Clemons, Eric K.
AU - Gerretsen, Rob
AU - Van Gelder, Allen
AU - Lyons, W. W.
AU - Shapiro, Marvin
AU - Maisel, Herbert
AU - Karp, Richard A.
AU - Borko, Harold
AU - Hartford, Donald L.
AU - Irwin, Alan E.
AU - Heffner, Horace
AU - Rockwell, Robert
AU - Fern, Jr., C. J.
AU - Baieman, Barry L.
AU - Durham, Paul
AU - Weicker, Reinhold
T1 - acm forum.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1977/06//
VL - 20
IS - 6
M3 - Letter
SP - 445
EP - 452
SN - 00010782
AB - Presents several letters to the editor referencing the topics and the articles published in the previous issues of the journal "Communications of the ACM." Comments on the article "Structured Programming in Cobol," which focused on the benefits of using structured programming; Information on different aspects of structured programming; Remarks on the publications from (Association for Computing Machinery).
KW - LETTERS to the editor
KW - STRUCTURED programming
KW - ELECTRONIC data processing -- Structured techniques
KW - COBOL (Computer program language)
KW - PUBLICATIONS
KW - ASSOCIATION for Computing Machinery
N1 - Accession Number: 17845614; Chapin, Ned 1 Denning, Peter J. 2 Rose, Lois A. Cichelli, Martha J. 3 Clemons, Eric K. 4 Gerretsen, Rob 4 Van Gelder, Allen Lyons, W. W. Shapiro, Marvin 5 Maisel, Herbert Karp, Richard A. 6 Borko, Harold 7 Hartford, Donald L. 8 Irwin, Alan E. Heffner, Horace Rockwell, Robert Fern, Jr., C. J. Baieman, Barry L. Durham, Paul Weicker, Reinhold 9; Affiliation: 1: InfoSci Inc., Box 7117, Menlo Park, CA 94025. 2: Computer Sciences Department, Purdue University, West Lafayette, IN 47907. 3: Software Consulting Services, Allentown, PA 18103. 4: Department of Decision Sciences, Wharton School University of Pennsylvania, Philadelphia, PA 19174. 5: Computer Division, National Institutes of Health, Bethesda, MD 20014. 6: Artificial Intelligence Laboratory, Stanford University Stanford, CA 94305. 7: University of California, Los Angeles, CA 90024. 8: Pepperdine University, Los Angeles, CA 90044. 9: Suenens AG, Erlangen, West Germany.; Source Info: Jun77, Vol. 20 Issue 6, p445; Subject Term: LETTERS to the editor; Subject Term: STRUCTURED programming; Subject Term: ELECTRONIC data processing -- Structured techniques; Subject Term: COBOL (Computer program language); Subject Term: PUBLICATIONS; Company/Entity: ASSOCIATION for Computing Machinery; Number of Pages: 8p; Document Type: Letter
L3 - 10.1145/359605.359635
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Schuster, Marvin M.
T1 - Gastrointestinal tract dysfunctions respond to biofeedback.
JO - Geriatrics
JF - Geriatrics
Y1 - 1977/06//
VL - 32
IS - 6
M3 - Interview
SP - 32
EP - 41
SN - 0016867X
N1 - Accession Number: 17321256; Schuster, Marvin M. 1,2,3; Source Information: Jun1977, Vol. 32 Issue 6, p32; Number of Pages: 3p; Document Type: Interview; Full Text Word Count: 1157
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Balow, J.E.
AU - Parrillo, J.E.
AU - Fauci, A.S.
T1 - Characterization of the direct effects of cyclophosphamide on cell-mediated immunological responses.
JO - Immunology
JF - Immunology
Y1 - 1977/06//
VL - 32
IS - 6
M3 - Article
SP - 899
PB - Wiley-Blackwell
SN - 00192805
AB - Examines the immunosuppressive effects of cyclophosphamide in normal guinea pig mononuclear cells. Induced changes in leucocyte functions; Depression of migration inhibitory factor production; Depression of certain cytotoxicity reactions.
KW - IMMUNOSUPPRESSION
KW - IMMUNOSUPPRESSIVE agents
KW - GUINEA pigs as laboratory animals
N1 - Accession Number: 11177608; Balow, J.E. 1 Parrillo, J.E. 1 Fauci, A.S. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, U.S.A.; Source Info: Jun77, Vol. 32 Issue 6, p899; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van Kammen, Daniel P.
AU - Money, John
T1 - EROTIC IMAGERY AND SELF-CASTRATION IN TRANSVESTISM/TRANSSEXUALISM: A CASE REPORT.
JO - Journal of Homosexuality
JF - Journal of Homosexuality
Y1 - 1977///Summer77
VL - 2
IS - 4
M3 - Article
SP - 359
EP - 366
SN - 00918369
AB - After nearly 30 years of marriage, a 51-year-old man castrated himself in order to fulfill a long-standing fantasy of being a girl. There was a prior history of cross-dressing since childhood, and of reversed erotic role imagery during coitus. There was no history of schizophrenia or psychotic depression. Pair bonding with the wife was very strong. It led the patient to elect low-dose maintenance on androgen so as to permit some degree of continued marital sex. Otherwise the patient would have preferred estrogenization and, perhaps, eventual sex reassignment. The rehabilitative program as a transvestite man has continued for 3 years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Homosexuality is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EROTICA
KW - CASTRATION
KW - PSYCHOSEXUAL disorders
KW - SEXUAL disorders
KW - GENDER dysphoria
KW - TRANSVESTISM
KW - TRANSSEXUALISM
KW - TRANSSEXUALS
N1 - Accession Number: 11783398; van Kammen, Daniel P. 1 Money, John 2; Affiliation: 1: Section on Neuropsychopharmacology, Adult Psychiatry Branch, National Institute of Mental Health 2: Departments of Psychiatry, Behavioral Sciences, and Pediatrics, Johns Hopkins University and Hospital; Source Info: Summer77, Vol. 2 Issue 4, p359; Subject Term: EROTICA; Subject Term: CASTRATION; Subject Term: PSYCHOSEXUAL disorders; Subject Term: SEXUAL disorders; Subject Term: GENDER dysphoria; Subject Term: TRANSVESTISM; Subject Term: TRANSSEXUALISM; Subject Term: TRANSSEXUALS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Beisler, J. A.;
AU - Peng, G. W.;
AU - Driscoll, J. S.;
T1 - Potential antitumor agents: procarbazine analogs and other methylhydrazine derivatives
CT - Potential antitumor agents: procarbazine analogs and other methylhydrazine derivatives
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1977/06/01/
VL - 66
IS - Jun
SP - 849
EP - 852
SN - 00223549
AD - Drug Design and Chemistry Section, Lab. of Medicinal Chemistry and Biology, Drug Research and Development Program, Div. of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20014
N1 - Accession Number: 14-5097; Language: English; Chemical Name: Procarbazine--671-16-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents procarbazine; References: 20; Journal Coden: JPMSAE; Section Heading: Pharmacology; Pharmaceutical Chemistry
N2 - With the objective of developing new antitumor agents, 2 groups of hydrazine compounds, having structural features in common with the antitumor agents procarbazine and 1-acetyl-2-picolinoylhydrazine, were synthesized. The L-1210 leukemia system was used to evaluate compounds of both groups. The aliphatic procarbazines also were screened for antitumor activity as bis(benzyloxycarbonyl) derivatives and as derivatives having a phthalazine nucleus. No L-1210 antitumor activity was exhibited by these compounds.
KW - Procarbazine--derivatives-;
KW - Hydrazines--synthesis--lack, antitumor effects, in vitro;
KW - Antineoplastic agents--hydrazines--synthesis, and lack, antitumor effects, in vitro;
KW - Antineoplastic agents--procarbazine--derivatives, aliphatic, synthesis, and lack, antitumor effects, in vitro;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ellenberg, Jonas H.
T1 - The Joint Distribution of the Standardized Row Sums of Squares from a Balanced Two-Way Layout.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1977/06//
VL - 72
IS - 358
M3 - Article
SP - 407
SN - 01621459
AB - A balanced two-way layout with no interaction is considered with the observations y[sub ij] being arranged in r rows and c columns (I = 1, ..., r, j = 1, ..., c). The error sum of squares for each row is defined as S[sub I] = SIGMA[sup c, sub j =1] (y[sub ij] - y[sub I.] - y[sub .j] + y[sub ..])[sup 2], and the total error sum of squares is defined as S = SIGMA[sup r, sub I=1] S[sub I]. The joint distribution of S[sub 1], ..., S[sub k] (k less than or equal to r) and the joint distribution of S[sub 1]/S, ..., S[sub k]/S (k < r) are derived. The distributional results are of the form conjectured by N.L. Johnson (1962). Finally, a procedure is considered for testing equality of the variances in the different rows which assumes the column variances are equal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - ANALYSIS of variance
KW - VARIANCES
KW - PROBABILITY theory
KW - STATISTICS
KW - EQUALITY
KW - Bonferroni inequality.
KW - Heterogeneity ut two-way layout
KW - Standardized row sums of squares
N1 - Accession Number: 4608461; Ellenberg, Jonas H. 1; Affiliations: 1: Acting Head, Section on Mathematical Statistics, Office of Biometry, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20014.; Issue Info: Jun77, Vol. 72 Issue 358, p407; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ANALYSIS of variance; Thesaurus Term: VARIANCES; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Subject Term: EQUALITY; Author-Supplied Keyword: Bonferroni inequality.; Author-Supplied Keyword: Heterogeneity ut two-way layout; Author-Supplied Keyword: Standardized row sums of squares; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Anderson, Dallas W.
T1 - Probability Sampling of Hospitals and Patients (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1977/06//
VL - 72
IS - 358
M3 - Book Review
SP - 483
SN - 01621459
AB - Reviews the book "Probability Sampling of Hospitals and Patients," 2nd ed., by Irene Hess, Donald C. Riedel and Thomas B. Fitzpatrick.
KW - PROBABILITY theory
KW - NONFICTION
KW - HESS, Irene
KW - RIEDEL, Donald
KW - RIEDEL, Donald C.
KW - FITZPATRICK, Thomas
KW - FITZPATRICK, Thomas B.
KW - PROBABILITY Sampling of Hospitals & Patients (Book)
N1 - Accession Number: 4608738; Anderson, Dallas W. 1; Affiliations: 1: National Institutes of Health.; Issue Info: Jun77, Vol. 72 Issue 358, p483; Thesaurus Term: PROBABILITY theory; Subject Term: NONFICTION; Reviews & Products: PROBABILITY Sampling of Hospitals & Patients (Book); People: HESS, Irene; People: RIEDEL, Donald; People: RIEDEL, Donald C.; People: FITZPATRICK, Thomas; People: FITZPATRICK, Thomas B.; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - YANG, SHEN K.
AU - MCCOURT, DAVID W.
AU - LEUTZ, JANET C.
AU - GELBOIN, HARRY V.
T1 - Benzo[a]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates.
JO - Science
JF - Science
Y1 - 1977/06/10/
VL - 196
IS - 4295
M3 - Article
SP - 1199
EP - 1200
SN - 00368075
AB - Studies of the mechanism of benzo[a]pyrene metabolism to reactive diol epoxides and of their disposition indicate that the metabolic intermediates of the activation pathways, 7,8-epoxide and trans-7,8-diol, as well as the two stereoisomeric diol epoxides are all optically active. Benzo[a]pyrene is converted to optically active 9, 10-epoxides of(-)trans-7,8-diol by three enzymatic steps: (i) stereospecific oxygenation at the 7,8 double bond of benzo[a]pyrene by the mixed-function oxidases to essentially a single enantiomer of 7,8-epoxide, (ii) hydration of the 7,8-epoxide by epoxide hydratase to an optically pure (-)trans-7,8-diol, and (iii) stereoselective oxygenation by the mixed-function oxidases at the 9,10 double bond of the (-) trans-7,8-diol to optically active r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene and optically active r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo-[a]pyrene in a ratio of approximately 10 to 1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460575; YANG, SHEN K. 1; MCCOURT, DAVID W. 1; LEUTZ, JANET C. 1; GELBOIN, HARRY V. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/10/1977, Vol. 196 Issue 4295, p1199; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BENZ, JR., EDWARD
AU - TURNER, PATRICIA
AU - BARKER, JANE
AU - NIENHUIS, ARTHUR
T1 - Stability of the Individual Globin Genes During Erythroid Differentiation.
JO - Science
JF - Science
Y1 - 1977/06/10/
VL - 196
IS - 4295
M3 - Article
SP - 1213
EP - 1214
SN - 00368075
AB - The genes for sheep βA, βC, and γ globin were all present in DNA from erythroid cells which synthesized only βC globin. Similarly, selective excision of non-expressed genes was shown not to occur during human erythroid differentiation. In contrast, evolutionary deletion of the βc gene accounts for the inability of many sheep to make this globin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460554; BENZ, JR., EDWARD 1; TURNER, PATRICIA 1; BARKER, JANE 1; NIENHUIS, ARTHUR 1; Affiliations: 1: Section on Clinical Hematology, Molecular Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Issue Info: 6/10/1977, Vol. 196 Issue 4295, p1213; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Carman, J. S.;
AU - Wyatt, R. J.;
T1 - Reduction of serum prolactin after subcutaneous salmon calcitonin
CT - Reduction of serum prolactin after subcutaneous salmon calcitonin
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1977/06/11/
VL - 1
IS - Jun 11
SP - 1267
EP - 1268
SN - 00237507
AD - Lab. of Clinical Psychopharmacology, National Institute of Mental Health, Washington, D.C. 20032
N1 - Accession Number: 14-6200; Language: English; Chemical Name: Calcitonin--9007-12-9; References: 7; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Joan Lentine
N2 - Injections of synthetic salmon calcitonin (I) resulted in a substantial decrease in serum prolactin in 9 psychotic inpatients. I and placebo injections were supplied in sterile vials of 200 MRC units/ml. Each patient was given at least one active and one placebo injection of 0.70 ml SC on the volar forearm at 7 p.m. each evening. From venous blood drawn at 7 a.m. on the following morning, serum prolactin was determined by radioimmunoassay.
KW - Calcitonin--salmon-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MINNERS, HOWARD A.
T1 - Tropical Medicine-New Vigor.
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1275
EP - 1275
SN - 00368075
N1 - Accession Number: 85218442; MINNERS, HOWARD A. 1; Affiliations: 1: Associate Director for International Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1275; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SLISKI, A. H.
AU - ESSEX, M.
AU - MEYER, C.
AU - TODARO, G.
T1 - Feline Oncornavirus-Associated Cell Membrane Antigen: Expression in Transformed Nonproducer Mink Cells.
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1336
EP - 1339
SN - 00368075
AB - The feline oncornavirus-associated cell membrane (tntigen (FOCMA) is a target for naturally occurring immunity that protec ts the cat against development of fibrosarcoma and leukemia. Feline sarcoma virus-transformed "nonproducer" mink cells express high levels of FOCMA, but not of the major viral structural proteins. Transformation of the same cells by murihe satrcoma virus, or infection with feline leukemia virus, which is nontransforming for epithelial or fibr-oblastic cells, did not induce FOCMA. Thus, FOCMA expression in mink lung cells is specifically associated with transformation by feline sarcoma virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218465; SLISKI, A. H. 1; ESSEX, M. 1; MEYER, C. 2; TODARO, G. 2; Affiliations: 1: Department of Microbiology, Harvard University School of Public Health, Boston, Massachusetts 02115; 2: Laboraitory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1336; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PIATIGORSKY, JORAM
AU - SHINOHARA, TOSHIMICHI
T1 - Lens Cataract Formation and Reversible Alteration in Crystallin Synthesis in Cultured Lenses.
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1345
EP - 1347
SN - 00368075
AB - Embryonic chick lenses developed cortical cataracts and altered their pattern of δ-crystallin synthesis within 3 hours, ifcultured without their vitreous body or traumatized with their vitreous body attached. δ-Crystallin reverted to the normal pattern by 24 hours in the cataractous lenses. Thus, biochemical differences that are only observable during the initial stages of cataractogenesis can exist between opaque and normal lenses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218469; PIATIGORSKY, JORAM 1; SHINOHARA, TOSHIMICHI 1; Affiliations: 1: Section on Cellular Differentiation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1345; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dienstag, Jules L.
AU - Alaama, Abdul
AU - Mosley, James W.
AU - Redeker, Allan G.
AU - Purcell, Robert H.
T1 - Etiology of Sporadic Hepatitis B Surface Antigen-Negative Hepatitis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 1
EP - 6
SN - 00034819
AB - We studied serologically 45 adults who had sporadic acute viral hepatitis that was hepatitis B surface antigen (HBsAg) negative. Two cases were due to hepatitis B virus, as demonstrated by the appearance of antibody to hepatitis B core antigen. in three other patients, the serologic pattern was Inconclusive. 0140 non-B cases, 20 were type A hepatitis and 20 were non-A, non-B hepatitis. Clinically, type A and non-A, non-B hepatitis were indistinguishable; one case of fulminent disease occurred in each group. The type A cases were more frequent in young adults; non-A, non-B disease predominated in women 35 years or older. Epidemiologic backgrounds were generally similar, including illicit self-injection; but four transfusion-associated cases were limited to the non-A, non-B group. We conclude that relatively few HBsAg-negative cases are due to hepatitis B virus, and that hepatitis A virus and non-A, non-B viruses are both important in acute non-B disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - LIVER diseases
KW - COMMUNICABLE diseases
KW - ANTIGENS
KW - DISEASES -- Causes & theories of causation
KW - HEMATOLOGY
N1 - Accession Number: 14147553; Dienstag, Jules L. 1,2; Alaama, Abdul 1,2; Mosley, James W. 1,2; Redeker, Allan G. 1,2; Purcell, Robert H. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p1; Subject: HEPATITIS; Subject: LIVER diseases; Subject: COMMUNICABLE diseases; Subject: ANTIGENS; Subject: DISEASES -- Causes & theories of causation; Subject: HEMATOLOGY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Szmuness, Wolf
AU - Dienstag, Jules L.
AU - Purcell, Robert H.
AU - Prince, Alfred M.
AU - Stevens, Cladd E.
AU - Levine, Richard W.
T1 - Hepatitis Type A and Hemodialysis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 8
EP - 12
SN - 00034819
AB - Four hundred sixty patients and staff from 15 U.S. dialysis centers were surveyed by the immune adherence hemagglutination technique for antibody to hepatitis A antigen (anti-HA) The age-standardized and-HA prevalence was 42.9% in patients and 42.1% In staff. These rates are almost Identical to those of socioeconomically comparable urban volunteer blood donors never exposed to dialysis settings. There was no correlation between anti-HA prevalences and duration of dialysis treatment or employment. Among 100 patients and staff followed for 1 year 92% to 94% did not change their anti-HA status. The prevalence, of anti-HA was identical In subjects with past histories of multiple blood transfusions or accidental Inoculations with blood-contaminated instruments and in those without such histories. We conclude that hepatitis A virus rarely if ever spreads by parenteral mechanisms that there is no epidemiologic evidence confirming the existence of chronic hepatitis A viremic carrier states, and that hemodlalysis does not play a significant role in the spread of type A hepatitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - LIVER diseases
KW - ANTIGENS
KW - DIALYSIS (Chemistry)
KW - HEMAGGLUTINATION tests
KW - HEMAGGLUTININ
N1 - Accession Number: 14147567; Szmuness, Wolf 1,2; Dienstag, Jules L. 1,2; Purcell, Robert H. 1,2; Prince, Alfred M. 1,2; Stevens, Cladd E. 1,2; Levine, Richard W. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p8; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: ANTIGENS; Subject: DIALYSIS (Chemistry); Subject: HEMAGGLUTINATION tests; Subject: HEMAGGLUTININ; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hoofnagle, Jay H.
AU - Gerety, Robert J.
AU - Tabor, Edward
AU - Feinstotne, Stephen M.
AU - Barker, Lewellys F.
AU - Purcell, Robert H.
T1 - Transmission of Non-A, Non-B Hepatitis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 14
EP - 20
SN - 00034819
AB - In studies conducted In the early 1950s, an from six asymptomatic blood donors, Implicated In the transmission of viral hepatitis, were Inoculated Into 10 to 20 volunteers each. Five of these "Implicated" donor sera transmitted clinically apparent hepatitis to the recipients. The stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis B virus and hepatitis A virus Infection. Two of the donor we were hepatitis B surface antigen (HBsAg)-positive, and both transmitted hepatitis B virus infection to all susceptible recipients, half of whom showed clinical symptoms. The remaining three Infectious donors were HBsAg-negative, yet were Icterogenic to 10% to 47% of recipients. Testing of serum samples from these recipients with hepatitis showed no evidence of hepatitis B virus or hepatitis A virus Infection. This study and other recent evidence suggest that there is a third type of human viral hepatitis--non-A, non-B hepatitis-which is due to a transmissible agent and may well be associated with a chronic carrier state. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - LIVER diseases
KW - BLOOD donors
KW - VIRAL hepatitis
KW - SERUM
KW - VIRUSES
N1 - Accession Number: 14147581; Hoofnagle, Jay H. 1,2; Gerety, Robert J. 1,2; Tabor, Edward 1,2; Feinstotne, Stephen M. 1,2; Barker, Lewellys F. 1,2; Purcell, Robert H. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p14; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: BLOOD donors; Subject: VIRAL hepatitis; Subject: SERUM; Subject: VIRUSES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Reimer, Ronald R.
AU - Chabner, Bruce A.
AU - Young, Robert C.
AU - Reddick, Robert
AU - Johnson, Ralph E.
T1 - Lymphoma Presenting in Bone.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 50
EP - 55
SN - 00034819
AB - Lymphoma presenting in bone (that is "reticulum cell sarcoma of bone") is a form of extranodal lymphoma historically described as frequently localized (that is, stage IE or stage IlE). Between 1970 and 1975, 14 patients with this entity were seen at the National Cancer Institute. This group had a variety of histologic subtypes of diffuse lymphoma. Thorough staging showed extensive disease (stage IV) in 12 of these patients (86%). in 10 of these the metastatic disease was unsuspected clinically. Seven patients achieved complete remissions after treatment with combination chemotherapy alone (two patients), irradiation alone (one patient), surgery alone (one patient), and both chemotherapy and irradiation (three patients) and are alive and free of disease 11 + to 70 + months after diagnosis. The other seven patients did not achieve complete remission status and have all died. Although lymphomas presenting in bone may occasionally be localized, careful staging in this series frequently showed extensive disease and altered the therapeutic approach. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOMAS
KW - RETICULO-endothelial system -- Tumors
KW - BONE
KW - CONNECTIVE tissues
KW - SARCOMA
KW - RETICULUM cell sarcoma
KW - DRUG therapy
N1 - Accession Number: 14150848; Reimer, Ronald R. 1; Chabner, Bruce A. 1; Young, Robert C. 1; Reddick, Robert 1; Johnson, Ralph E. 1; Source Information: Jul77, Vol. 87 Issue 1, p50; Subject: LYMPHOMAS; Subject: RETICULO-endothelial system -- Tumors; Subject: BONE; Subject: CONNECTIVE tissues; Subject: SARCOMA; Subject: RETICULUM cell sarcoma; Subject: DRUG therapy; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Meyers, Joel D.
AU - Jules L. Dienstag
AU - Robert H. Purcell
AU - E. Donnall Thomas
AU - King K. Holmes
T1 - Parenterally Transmitted Non-A, Non-B Hepatitis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 57
EP - 59
SN - 00034819
AB - in 1912 a nosocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. Because of the characteristics of the clinical illness, the Incubation period of 27 days, and the effect of Immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis A; there was no serologic evidence of either hepatitis B virus or cytomegalovirus infection. Stored serums from this outbreak were re-examined by more recently developed serologic techniques for evidence of hepatitis A (HA) virus infection. Ten patients and donors had undetectable anti-HA titers before illness and none seroconverted; five persons had pre-existent anti-HA titers and showed no further rise in convalescent serums. The serum of one patient was inevaluable. With the availability of serologic techniques for the diagnosis of both hepatitis A and hepatitis B virus infections, it is clear that most cases of post-transfusion hepatitis are not due to either of these agents, and shorts incubation-period hepatitis can not be assumed to be hepatitis A without further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - LIVER diseases
KW - NOSOCOMIAL infections
KW - IMMUNOGLOBULINS
KW - CYTOMEGALOVIRUS diseases
KW - HERPESVIRUS diseases
N1 - Accession Number: 14150883; Meyers, Joel D. 1,2,3; Jules L. Dienstag 1,2,3; Robert H. Purcell 1,2,3; E. Donnall Thomas 1,2,3; King K. Holmes 1,2,3; Source Information: Jul77, Vol. 87 Issue 1, p57; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: NOSOCOMIAL infections; Subject: IMMUNOGLOBULINS; Subject: CYTOMEGALOVIRUS diseases; Subject: HERPESVIRUS diseases; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Crystal, Ronald G.
T1 - Pathology of Disruptive Pulmonary Emphysema (Book).
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Book Review
SP - 140
EP - 140
SN - 00034819
AB - Reviews the book "Pathology of Disruptive Pulmonary Emphysema," by A. E. Anderson and Alvan G. Foraker.
KW - PATHOLOGY of Disruptive Pulmonary Emphysema (Book)
KW - ANDERSON, A. E.
KW - FORAKER, Alvan G.
KW - PULMONARY emphysema
KW - NONFICTION
N1 - Accession Number: 14152277; Crystal, Ronald G. 1; Source Information: Jul77, Vol. 87 Issue 1, p140; Subject: PATHOLOGY of Disruptive Pulmonary Emphysema (Book); Subject: ANDERSON, A. E.; Subject: FORAKER, Alvan G.; Subject: PULMONARY emphysema; Subject: NONFICTION; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Penta, J. S.;
AU - Helman, L. J.;
AU - Slavik, M.;
T1 - Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration
CT - Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration
JO - Cancer Treat. Rep.
JF - Cancer Treat. Rep.
Y1 - 1977/07/01/
VL - 61
IS - Jul
SP - 745
EP - 748
AD - Div. of Cancer Treatment, National Cancer Institute, Bldg. 37, Rm. 6E12, Bethesda, Maryland 20014
N1 - Accession Number: 14-5778; Language: English; Trade Name: Citrovorum factor; Generic Name: Leucovorin; Chemical Name: Methotrexate--59-05-2 Leucovorin--58-05-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate and leucovorin (10:00); AHFS Class: Antineoplastic agents leucovorin and methotrexate; References: 12; Journal Coden: CCYPBY; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations
N2 - A review of 498 patients treated with high dose methotrexate (I) and leucovorin rescue revealed 29 drug related deaths. Until the important factors in those deaths are identified, the use of high dose I should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.
KW - Methotrexate--and leucovorin-;
KW - Leucovorin--and methotrexate-;
KW - Toxicity--methotrexate and leucovorin--studies, retrospective, deaths, high dose with rescue, and recommendations;
KW - Toxicity--leucovorin and methotrexate--studies, retrospective, deaths, high dose with rescue, and recommendations;
KW - Dosage--methotrexate and leucovorin--toxicity, retrospective studies, deaths, high with rescue, and recommendations;
KW - Antineoplastic agents--methotrexate and leucovorin--toxicity, retrospective studies, deaths, high dose with rescue, and recommendations;
KW - Antineoplastic agents--leucovorin and methotrexate--toxicity, retrospective studies, deaths, high dose with rescue, and recommendations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ottesen, E. A.
AU - Poindexter, R. W.
AU - Hiatt, R. A.
T1 - 'Long--distance' lymphocyte study THE EFFECTS OF TRANSPORTING BLOOD ON LYMPHOCYTE BLASTOGENIC RESPONSES.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/07//
VL - 29
IS - 1
M3 - Article
SP - 168
EP - 172
PB - Wiley-Blackwell
SN - 00099104
AB - A comparison of blastogenic responsiveness to antigens and mitogen by human lymphocytes was made between cells which had been processed for culture immediately following blood collection and cells obtained from blood collected 9-11 hr previously and transported via commercial airline from the patients' homes to our laboratory. There were no significant differences in the responses of transported and non-transported cells if the blood was maintained at ambient temperature during the period of shipment. Chilling the blood during transport, however, resulted both in decreased stimulation of the cells and increased `background' activity in unstimulated cultures. These findings indicate the feasibility of carrying out both limited immunological evaluations and extended periods of follow-up for patients located at considerable distances from a research laboratory. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - KILLER cells
KW - BLOOD cells
KW - T cells
KW - BLOOD collection
N1 - Accession Number: 15945431; Ottesen, E. A. 1 Poindexter, R. W. 1 Hiatt, R. A. 2; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of AlIergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: San Juan Laboratories, Bureau of Laboratories, Center for Disease Control, San Juan, Puerto Rico.; Source Info: Jul1977, Vol. 29 Issue 1, p168; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: KILLER cells; Subject Term: BLOOD cells; Subject Term: T cells; Subject Term: BLOOD collection; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobowitz, David M.
T1 - CONTROLLING INFLUENCES OF THE AUTONOMIC NERVOUS SYSTEM.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/07//
VL - 69
IS - 1
M3 - Article
SP - 106
EP - 111
SN - 0022202X
AB - Recent information about the localization of sympathetic nerves and catecholamine-containing cells suggests sites of action not usually described in the neuroscience textbooks. In this study, we focused on the autonomic controls that affect ganglia, heart, gut, and chemoreceptors. As a result of some speculation derived mainly from histochemical observations and partially from physiologic data, we concluded that at the organ level the interplay between a nerve terminal-receptor serves as a local control. Additional controls may function at the ganglion level where catecholamine-containing chromaffin cells may serve as interneurons. We suggest that all peripheral catecholamine-containing elements which function in a modulatory role are not vital to the survival of the individual but rather serve as "fine tune" adjustment that do not involve the central nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTONOMIC nervous system
KW - CATECHOLAMINES
KW - SENSORY ganglia
KW - CHROMAFFIN cells
KW - NEURONS
KW - NERVOUS system
N1 - Accession Number: 12497906; Jacobowitz, David M. 1; Affiliation: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p106; Subject Term: AUTONOMIC nervous system; Subject Term: CATECHOLAMINES; Subject Term: SENSORY ganglia; Subject Term: CHROMAFFIN cells; Subject Term: NEURONS; Subject Term: NERVOUS system; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12497906
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Price, Donald D.
AU - Dubner, Ronald
T1 - MECHANISMS OF FIRST AND SECOND PAIN IN THE PERIPHERAL AND CENTRAL NERVOUS SYSTEMS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/07//
VL - 69
IS - 1
M3 - Article
SP - 167
EP - 171
SN - 0022202X
AB - Brief (< 2.0 sec) noxious heat pulses (peak temp = 51.5°C) programmed by a computer and generated by a contact thermode produced first and second pain in human subjects. Measurements of reaction time confirmed that these first and second pains were related to the conduction of impulses in Aδ heat nociceptive and C polymodal nociceptive afferents respectively. Estimates of psychophysical magnitude showed that when four identical heat pulses were applied to the same spot on the hand (interstimulus interval ≤ 80 sec), the first pain progressively decreased in perceived intensity whereas the second pain increased with interstimulus intervals of 3 sec or less. The first pain did not decrease if the location of the thermode was changed between each stimulus whereas the summation of the second pain increased under these conditions. Identical trains of noxious heat pulses partially suppressed the responses of Aδ and of C nociceptive afferents. These psychophysical observations and physiologic records indicate that the temporal suppression of heat-induced first pain is related to the suppression of Aδ heat nociceptors and that prolonged temporal summation of second pain is related to summation within the central nervous system. Aδ heat nociceptive afferents and C polymodal nociceptive afferents converge on two types of spinothalamic tract neurons: (1) wide dynamic-range neurons that receive input from non-nociceptive and nociceptive afferents. and (2) nociceptive-specific neurons. Since both types show summation of responses to repeated C fiber stimulation, they can account for summation of second pain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIPHERAL nervous system
KW - CENTRAL nervous system
KW - HEAT pulses
KW - HEAT transfer
KW - THERMAL desorption
KW - NERVOUS system
N1 - Accession Number: 12497942; Price, Donald D. 1 Dubner, Ronald 1; Affiliation: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p167; Subject Term: PERIPHERAL nervous system; Subject Term: CENTRAL nervous system; Subject Term: HEAT pulses; Subject Term: HEAT transfer; Subject Term: THERMAL desorption; Subject Term: NERVOUS system; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12497942
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12497942&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Semmes, Josephine
AU - Turner, Blair
T1 - EFFECTS OF CORTICAL LESIONS ON SOMATOSENSORY TASKS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/07//
VL - 69
IS - 1
M3 - Article
SP - 181
EP - 189
SN - 0022202X
AB - Lesions were made in the subdivisions of the postcentral gyrus and in related cortical areas of monkeys. After the operation, the monkeys were trained on six tactual discrimination problems, and their performance was compared with those of a normal control group. Severe and apparently permanent damage to the ability to perform all tasks was observed after the postcentral lesions, but little or no effects were seen after the removal of the motor cortex or of the posterior parietal lobule. Destruction of area 3 of the postcentral gyrus had the most serious consequences, the monkeys with this lesion being unable to learn any but the easiest descriminations. Lesions of area 1 or of area 2 resulted in an inferior performance of tasks which required information mainly from cutaneous or deep receptors, respectively. The results of these behavioral studies support and extend the anatomical and physiologic data that demonstrate that the postcentral gyrus consists of a core area, which receives the heaviest thalamic projection and is crucial to a broad range of somatosensory functions. flanked by areas selectively responsive to stimulation of the cutaneous or the deep receptors. The fact that lesions of areas closely connected to the postcentral gyrus by corticocortical fibers do not impair somatosensory discriminations suggests that the necessary abilities are based mainly on the relation with the thalamus rather than on interareal cortical integration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOMATOSENSORY evoked potentials
KW - EVOKED potentials (Electrophysiology)
KW - MONKEYS
KW - MOTOR cortex
KW - FRONTAL lobes
KW - THALAMUS
N1 - Accession Number: 12497948; Semmes, Josephine 1,2 Turner, Blair 1,2; Affiliation: 1: Behavioral Sciences Research Branch, National Institute of Mental Health, Rockville, Maryland. 2: Department of Anatomy, Howard University Medical School, Washington, D. C., U. S. A.; Source Info: Jul77, Vol. 69 Issue 1, p181; Subject Term: SOMATOSENSORY evoked potentials; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: MONKEYS; Subject Term: MOTOR cortex; Subject Term: FRONTAL lobes; Subject Term: THALAMUS; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1523-1747.ep12497948
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lehr, Roland E.
AU - Jerina, Donald M.
T1 - Relationships of quantum mechanical calculations, relative mutagenicity of benzom anthracene diol epoxides, and “bay region” concept of aromatic hydrocarbon carcinogenicity.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/07//
VL - 2
IS - 6
M3 - Article
SP - 1259
EP - 1265
SN - 00984108
AB - Evidence supporting the conclusion that 7,8‐dihydroxy‐9,10‐epoxy‐7,8,9,10‐tetra‐hydrobenzo[a]pyrenes are ultimate mutagenic and carcinogenic forms of benzo[a]‐pyrene (BP) is summarized. Quantum mechanical calculations that predict reactivity of diol epoxides derived from BP and other polycyclic aromatic hydrocarbons are described. The calculations predict that diol epoxides in which the oxirane ring forms part of a “bay region” of a tetrahydrobenzo ring should be the most reactive for a given aromatic hydrocarbon. Experiments with dihydrodiols and diol epoxides from benzo[a]anthracene (BA) are described. The ability to metabolically activate BA 3,4‐dihydrodiol to species much more mutagenic than those obtained from other BA dihydrodiols and the much greater mutagenicity of the diastereoisomeric 3,4‐diol‐1,2‐epoxides of 1,2,3,4‐tetrahydro BA relative to other diol epoxides of BA are in accord with predictions of the quantum mechanical calculations. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456895; Lehr, Roland E. 1,2 Jerina, Donald M. 1; Affiliation: 1: Laboratory of Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 2: Department of Chemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma, 73019; Source Info: Jul1977, Vol. 2 Issue 6, p1259; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15287397709529528
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saffiotti, Umberto
T1 - Scientific bases of environmental carcinogenesis and cancer prevention: Developing an interdisciplinary science and facing its ethical implications.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/07//
VL - 2
IS - 6
M3 - Article
SP - 1435
EP - 1447
SN - 00984108
AB - Two distinct types of toxic effects are defined: (1) terminal toxic effects, characterized by early appearance, direct correlation of the intensity of induced pathology with the intensity of exposure, and manifestation of toxicity due to altered functional products, degeneration, or death of the target cells themselves, and (2) self‐replicating toxic effects, characterized by delayed appearance, direct correlation of the frequency of induced pathology with the intensity of exposure, independence of the intensity of induced pathology from the intensity of exposure, and manifestation of toxicity due to proliferation of a new altered cell population. Traditional toxicology deals with terminal effects, but is inadequate to deal with self‐replicating effects, for which a new toxicology is developing. New knowledge of cellular and molecular mechanisms of self‐replicating toxicity has revolutionary implications for the evaluation of environmental toxicology. The mechanisms of carcinogenesis represent an example at the somatic cell level of the general theory of biological evolution by chance events followed by the necessity of biological expression as outlined by Monod in 1970. The implications of modern biological knowledge were developed by Monod into the ethic of knowledge. The scientific method, based on the postulate of objectivity, rejects any confusion between knowledge and “values.” In toxicology, value judgment on societal consequences of discovering chemicobiological interactions should absolutely not interfere with the objective pursuit of scientific evidence. The relationship between etiology and ethics demands high professional and ethical standards, comparable to those accepted in forensic medicine. High quality standards of scientific methodology, provisions to avoid any conflict of interest, and the establishment of licensed laboratories are recommended. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456909; Saffiotti, Umberto 1; Affiliation: 1: National Cancer Institute, National Institutes of Health, Experimental Pathology Branch, Carcinogenesis Program, Division of Cancer Cause and Prevention, Bethesda, Maryland, 20014; Source Info: Jul1977, Vol. 2 Issue 6, p1435; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/15287397709529542
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=75456909&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DAVIS, GLENN C.
AU - BUNNEY JR., WILLIAM E.
AU - DEFRAITES, EMANUEL G.
AU - KLEINMAN, JOEL E.
AU - VAN KAMMEN, DANIEL P.
AU - POST, ROBERT M.
AU - WYATT, RICHARD J.
T1 - Intravenous Naloxone Administration in Schizophrenia and Affective Illness.
JO - Science
JF - Science
Y1 - 1977/07//7/1/1977
VL - 197
IS - 4298
M3 - Article
SP - 74
EP - 77
SN - 00368075
AB - Fourteen schizophrenic patients and five patients with affective disorders were given naloxone (0.4 to 10 milligrams) or placebo intravenously in a double-blind fashion. Physicians' ratings of hallucinations, mannerisms and posturing, conceptual disorganization, psychosis, and mood did not change significantly. A single item, unusual thought content, improved significantly on the naloxone day compared to the placebo, day. There was no improvement in mood in affectively ill patients rated either by themselves or by physicians. Naloxone did not markedly improve any patient studied, which suggests that the acute blockade of opiate receptors is not associated with global improvement in psychotic symptomatology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87465326; DAVIS, GLENN C. 1; BUNNEY JR., WILLIAM E. 1; DEFRAITES, EMANUEL G. 1; KLEINMAN, JOEL E. 2; VAN KAMMEN, DANIEL P. 3; POST, ROBERT M. 3; WYATT, RICHARD J. 2; Affiliations: 1: Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health; 3: Adult Psychiatry Branch, National Institute of Mental Health; Issue Info: 7/1/1977, Vol. 197 Issue 4298, p74; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2013-42989-013
AN - 2013-42989-013
AU - Brown, Bertram S.
T1 - Conflict and detente between social issues and clinical practice.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1977/07//
VL - 47
IS - 3
SP - 466
EP - 475
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Brown, Bertram S., National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2013-42989-013. PMID: 888923 Partial author list: First Author & Affiliation: Brown, Bertram S.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Business Meeting of the Annual Meeting of the American Orthopsychiatric Association, 1977, New York, NY, US. Conference Note: This research were presented at the aforementioned conference. Major Descriptor: Clinical Practice; Mental Health; Mental Health Personnel; Professional Development; Social Issues. Minor Descriptor: Advocacy; Conflict. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1977.
AB - The 'dual nature' of the mental health profession—embodied in the differences between advocates of social and clinical approaches to people's problems—is considered. It is suggested that the situation reflects realities of the world we live in, and that it contains both dilemma and opportunity. Areas in which social advocacy and clinical expertise have complemented each other are illustrated, and possibilities for constructive and creative conflict are suggested. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conflict
KW - mental health profession
KW - clinical expertise
KW - problem solving
KW - reflects realities
KW - social advocacy
KW - 1977
KW - Clinical Practice
KW - Mental Health
KW - Mental Health Personnel
KW - Professional Development
KW - Social Issues
KW - Advocacy
KW - Conflict
KW - 1977
DO - 10.1111/j.1939-0025.1977.tb01253.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42989-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42989-016
AN - 2013-42989-016
AU - Davenport, Yolande B.
AU - Ebert, Michael H.
AU - Adland, Marvin L.
AU - Goodwin, Frederick K.
T1 - Couples group therapy as an adjunct to lithium maintenance of the manic patient.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1977/07//
VL - 47
IS - 3
SP - 495
EP - 502
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Davenport, Yolande B., Section on Psychiatry, LCS, 900 Rockville Pike, Clinical Center, Room 4S-239, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-42989-016. PMID: 196507 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Couples Therapy; Drug Therapy; Group Psychotherapy; Mania. Minor Descriptor: Lithium. Classification: Affective Disorders (3211); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 1977.
AB - Use of couples therapy groups in conjunction with lithium in the long-term management of married manic-depressive patients is described. Among bipolar patients on lithium, those in couples group therapy had more benign posthospital course than those given minimal support beyond medication. The structure and benefits of the couples group are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - couples group therapy
KW - lithium maintenance
KW - manic patient
KW - medication
KW - 1977
KW - Bipolar Disorder
KW - Couples Therapy
KW - Drug Therapy
KW - Group Psychotherapy
KW - Mania
KW - Lithium
KW - 1977
DO - 10.1111/j.1939-0025.1977.tb01256.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42989-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42989-036
AN - 2013-42989-036
AU - Wittman, Milton
T1 - Review of Crowding and behavior: The psychology of high-density living and Public places and private spaces: The psychology of work, play, and living environments.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1977/07//
VL - 47
IS - 3
SP - 554
EP - 556
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42989-036. Partial author list: First Author & Affiliation: Wittman, Milton; Social Work Education Branch, Division of Manpower and Training Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Crowding; Environmental Psychology; Individual Differences; Public Sector; Social Behavior. Minor Descriptor: Books; Home Environment; Psychology; Stress. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Freedman, Jonathan. Crowding and behavior: The psychology of high-density living=177 pp. $17.95. Viking Press, New York; 1976. Mehrabian, Albert. Public places and private spaces: The psychology of work, play, and living environments=354 pp. $15.95. Basic Books, New York; 1976. Page Count: 3. Issue Publication Date: Jul, 1977.
AB - Reviews the books, Crowding and Behavior: The Psychology of High-Density Living by Jonathan Freedman (1976) and Public Places and Private Spaces: The Psychology of Work, Play, and Living Environments by Albert Mehrabian (1976). The two books under review represent quite different reports on the now familiar topic of environment, ecology, and human behavior. Taken together, they provide an unusually comprehensive overview of environmental psychology. The Mehrabian work, in contrast, represents a very general overview of a wide variety of psychological, ethological, and social relationships to the environment, and contains a wide-ranging discussion of how these are applied to knowledge about the impact of the environment on individual and social behavior. In the early part of his book, Mehrabian amplifies on what is called the General Adaptation Syndrome (GAS) . This is seen as a means of assessing psychosocial reactions to given environmental situations. The General Adaptation Syndrome is affected by 'high loading' and 'low loading' in all experiences. One can assume that almost any experience in life, whether it relates to work, play, education, or recreation, has environmental implications. In attempting to cover a wide range of topics, the author treats some rather superficially. Additional references at the end of each chapter are a helpful resource. The Freedman book is less easily read but does contain some in-depth reporting on research dealing with crowding and behavior. Both books certainly warrant scrutiny on the part of those in the helping and design professions who wish to become more informed about the physical environment in which they and their clients live and work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - crowding
KW - behavior
KW - psychology
KW - public places
KW - environmental implications
KW - social behavior
KW - individual differences
KW - 1977
KW - Crowding
KW - Environmental Psychology
KW - Individual Differences
KW - Public Sector
KW - Social Behavior
KW - Books
KW - Home Environment
KW - Psychology
KW - Stress
KW - 1977
U2 - Freedman, Jonathan. (1976); Crowding and behavior: The psychology of high-density living; 177 pp. $17.95. Viking Press, New York
U2 - Mehrabian, Albert. (1976); Public places and private spaces: The psychology of work, play, and living environments; 354 pp. $15.95. Basic Books, New York
DO - 10.1037/h0099039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42989-036&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Wallace, R. B.;
AU - Hoover, J.;
AU - Sandler, D.;
AU - Rifkind, B. M.;
AU - Tyroler, H. A.;
T1 - Altered plasma lipids associated with oral contraceptive or estrogen consumption
CT - Altered plasma lipids associated with oral contraceptive or estrogen consumption
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1977/07/02/
VL - 2
IS - Jul 2
SP - 11
EP - 14
SN - 00237507
AD - Lipid Metabolism Branch, Div. of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland
N1 - Accession Number: 15-0131; Language: English; References: 21; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Mean plasma cholesterol and triglyceride concentrations were measured in white female users and nonusers of oral contraceptives and estrogens in 10 diverse, demographically defined North American populations. A total of 18,461 women between the ages of 15 and 74 was studied. About 50% of the younger women (20-24 yr old) were taking oral contraceptives. In these women mean triglyceride concentrations were about 5% higher than in nonusers. The 95% percentile of the total lipid distribution among nonusers was used to define hyperlipidemia. In young women on oral contraceptives, hypercholesterolemia was up to 3 times more common and hypertriglyceridemia was up to 5 times more common than in nonusers. Of older women (50-54 yr) 37% (presumably intramenopausal and postmenopausal) were hormone users, and in this group there were small, inconsistent alterations in plasma triglyceride and a modest but consistent reduction in mean cholesterol concentration.
KW - Contraceptives, oral--effects--plasma cholesterol and triglyceride levels, patients;
KW - Estrogens--effects--plasma cholesterol and triglyceride levels, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MYERS, CHARLES E.
AU - MCGUIRE, WILLIAM P.
AU - LISS, ROBERT H.
AU - IFRIM, INA
AU - GROTZINGER, KAREN
AU - YOUNG, ROBERT C.
T1 - Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response.
JO - Science
JF - Science
Y1 - 1977/07/08/
VL - 197
IS - 4299
M3 - Article
SP - 165
EP - 167
SN - 00368075
AB - The antitumor antibiotic, adriamycin, induces severe cardiac toxicity associated with peroxidation of cardiac lipids in mice. Both this lipid peroxidation and cardiac toxicity of adriamycin are reduced by prior treatment of the animals with the free radical scavenger tocopherol. Such treatment with tocopherol does not, however, alter the magnitude or duration of the adriamycin-induced suppression of DNA synthesis in P388 ascites tumor, nor does it diminish the antitumor responsiveness of P388 ascites tumor. These results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which involves binding to DNA, is not antagonized by tocopherol and is responsible for tumor response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87465360; MYERS, CHARLES E. 1; MCGUIRE, WILLIAM P. 2; LISS, ROBERT H. 3; IFRIM, INA 3; GROTZINGER, KAREN 4; YOUNG, ROBERT C. 4; Affiliations: 1: Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Combined Modalities Branch, National Cancer Institute; 3: Arthur D. Little, Inc., Cambridge, Massachusetts 02166; 4: Medicine Branch, National Cancer Institute; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p165; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZATZ, MARTIN
AU - O'DEA, ROBERT F.
T1 - Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′, 5′-Monophosphate from Sympathetic Nerve Endings.
JO - Science
JF - Science
Y1 - 1977/07/08/
VL - 197
IS - 4299
M3 - Article
SP - 174
EP - 176
SN - 00368075
AB - Potassium and norepinephrine stimulate the efflux of adenosine 3′,5′-monophosphate (cyclic AMP) and guanosine 3′,5′-monophosphate (cyclic GMP) from intact pineal glands. The postsynaptic β-adrenergic receptor mediates the efflux of cyclic AMP. In contrast, the efflux of cyclic GMP requires calcium and intact nerve endings. It appears that sympathetic nerve endings may release cyclic GMP into the synaptic space. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87465365; ZATZ, MARTIN 1; O'DEA, ROBERT F. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p174; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LERNER, PAULINE
AU - NOSE, PETER
AU - GORDON, EDNA K.
AU - LOVENBERG, WALTER
T1 - Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover.
JO - Science
JF - Science
Y1 - 1977/07/08/
VL - 197
IS - 4299
M3 - Article
SP - 181
EP - 183
SN - 00368075
AB - The short- and long-term effects of neuroleptic. drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87465368; LERNER, PAULINE 1; NOSE, PETER 1; GORDON, EDNA K. 2; LOVENBERG, WALTER 1; Affiliations: 1: Section on Biochemical Pharmacology, Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 7/8/1977, Vol. 197 Issue 4299, p181; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Ziegler, J. L.;
T1 - Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience
CT - Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1977/07/14/
VL - 297
IS - Jul 14
SP - 75
EP - 80
SN - 00284793
AD - Clinical Oncology Program, Div. of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 15-0081; Language: English; Chemical Name: Cyclophosphamide--6055-19-2 Methotrexate--59-05-2 Vincristine--57-22-7 Prednisolone--50-24-8; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cyclophosphamide (10:00); AHFS Class: Antineoplastic agents methotrexate (10:00); AHFS Class: Antineoplastic agents vincristine (10:00); AHFS Class: Antineoplastic agents prednisolone; References: 25; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Fifty-four Americans with Burkitt's lymphoma were treated with 2 sequential combined treatment regimens based upon therapeutic approaches from clinical trials in Africa. One treatment regimen consisted of cyclophosphamide, methotrexate and vincristine. The other treatment regimen consisted of cyclophosphamide, methotrexate, prednisolone and vincristine. Chemotherapy courses in both protocols were administered IV or intrathecally at intervals determined by recovery of the peripheral white cell count to 4500/cu mm. Four patients died during induction therapy, and 48 of the remaining 50 achieved complete remissions. Twenty-two relapsed at a median of 3 months from the start of therapy. The overall 2-yr actuarial survival was 54%: younger patients (\LT/ 12-yr-old) and patients with minimal tumor burden (stages A, B and AR) had significantly better survivals than older patients (P \LT/ 0.02) and patients with advanced abdominal tumors (stages C and D) (P \LT/ 0.01). No differences in survival were detected between patients treated at the National Institutes of Health and those treated in their regional institutions on either protocol. These results suggest that complete response rates, relapse frequency and survival in American patients are similar to results in Africa.
KW - Cyclophosphamide--Burkitt's lymphoma-;
KW - Methotrexate--Burkitt's lymphoma-;
KW - Vincristine--Burkitt's lymphoma-;
KW - Prednisolone--Burkitt's lymphoma-;
KW - Dosage schedules--cyclophosphamide--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW - Dosage schedules--methotrexate--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW - Dosage schedules--vincristine--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW - Dosage schedules--prednisolone--Burkitt's lymphoma, combined therapy, sequential, American patients;
KW - Combined therapy--cyclophosphamide--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW - Combined therapy--methotrexate--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW - Combined therapy--vincristine--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW - Combined therapy--prednisolone--Burkitt's lymphoma, dosage schedules, sequential, American patients;
KW - Antineoplastic agents--cyclophosphamide--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW - Antineoplastic agents--methotrexate--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW - Antineoplastic agents--vincristine--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW - Antineoplastic agents--prednisolone--Burkitt's lymphoma, dosage schedules, combined therapy, sequential, American patients;
KW - Race--antineoplastic agents--Burkitt's lymphoma, combined therapy, sequential dosage schedules, American patients;
KW - Drug utilization--antineoplastic agents--Burkitt's lymphoma, combined therapy, sequential dosage schedules, American patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - NOBLE, ERNEST P.
T1 - Wine and Viral Diseases.
JO - Science
JF - Science
Y1 - 1977/07/15/
VL - 197
IS - 4300
M3 - Article
SP - 208
EP - 210
SN - 00368075
N1 - Accession Number: 87459846; NOBLE, ERNEST P. 1; Affiliations: 1: National Institute on Alcohol Abuse and Alcoholism, Public Health Service, Rockville, Maryland 20852; Issue Info: 7/15/1977, Vol. 197 Issue 4300, p208; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YOON SANG CHO-CHUNG
AU - REDLER, BRUCE H.
T1 - Dibutyryl Cyclic AMP Mimics Ovariectomy: Nuclear Protein Phosphorylation in Mammary Tumor Regression.
JO - Science
JF - Science
Y1 - 1977/07/15/
VL - 197
IS - 4300
M3 - Article
SP - 272
EP - 275
SN - 00368075
AB - Growth of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene is arrested by either ovariectomy or treatment with N6, 02'-dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP). When this occurs, a new nonhistone protein species becomes the predominant endogenous substrate of cyclic AMP-dependent protein kinase in the tumor nuclei. Phosphorylation of this regression-associated protein ceases when resumption oftumor growth is induced by either the injection of 17,βestradiol or cessation of dibutyryl cyclic AMP treatment. Thus phosphorylation of regression-associated protein may play a role in the regression of hormone-dependent mammary tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87459828; YOON SANG CHO-CHUNG 1; REDLER, BRUCE H. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 7/15/1977, Vol. 197 Issue 4300, p272; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Castelli, W. P.;
AU - Gordon, T.;
AU - Hjortland, M. C.;
AU - Kagan, A.;
AU - Doyle, J. T.;
AU - \ET/;
T1 - Alcohol and blood lipids: Cooperative Lipoprotein Phenotyping Study
CT - Alcohol and blood lipids: Cooperative Lipoprotein Phenotyping Study
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1977/07/23/
VL - 2
IS - Jul 23
SP - 153
EP - 155
SN - 00237507
AD - National Heart, Lung, and Blood Institute, Landow Bldg., Rm. C841, 7910 Woodmont Ave., Bethesda, Maryland 20014
N1 - Accession Number: 15-0432; Language: English; Chemical Name: Alcohols, ethyl--64-17-5; References: 20; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Data from 5 study populations (total of 3,806 patients) participating in the Cooperative Lipoprotein Phenotyping Study indicate strong relations between reported alcohol consumption and blood lipids. Alcohol consumption was positively associated with a high density lipoprotein cholesterol level in all populations (r from 0.16 to 0.30), the lipid level appearing to be a graded response even over the low levels of alcohol consumption reported. Less strong but consistently negative correlations were found with low density lipoprotein cholesterol. Plasma triglycerides showed a modest positive correlation with alcohol. The 5 populations were those of the Albany, Evans County, Framingham, Honolulu, and San Francisco Studies.
KW - Alcohols, ethyl--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Reimer, R. R.;
AU - Hoover, R.;
AU - Fraumeni, J. F.;
AU - Young, R. C.;
T1 - Acute leukemia after alkylating agent therapy of ovarian cancer
CT - Acute leukemia after alkylating agent therapy of ovarian cancer
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1977/07/28/
VL - 297
IS - Jul 28
SP - 177
EP - 181
SN - 00284793
AD - Environmental Epidemiology Branch, Landow Bldg., Rm. A521, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 15-0030; Language: English; References: 40; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2 - To estimate the leukemogenic potential of alkylating agents, 70 institutions using these drugs for the frequency of second cancers in patients with advanced ovarian cancer were surveyed. Thirteen cases of acute nonlymphocytic leukemia occurred among 5,455 patients, as compared to 0.62 cases expected (relative risk = 21.0). All 13 had received alkylating agents. Nine also received radiotherapy. The relative risk for patients given chemotherapy was 36.1 and rose to 171.4 for those surviving for 2 years (rate = 13.75/1000 patients/year). To evaluate the role of therapy versus underlying disease, a historical control of 13,309 patients with ovarian cancer in the National Cancer Institute's End Results Program was analyzed. No excess of leukemia was noted in this group, even among 6,596 women receiving radiation. The excess of acute nonlymphocytic leukemia, therefore, appears attributable to alkylating agents, although the effect may be enhanced by exposure to radiation, as previously suggested for Hodgkin's disease.
KW - Antineoplastic agents--toxicity--studies, leukemia, ovarian cancer patients;
KW - Toxicity--antineoplastic agents--studies, leukemia, ovarian cancer patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Penta, John S.
AU - von Hoff, Daniel D.
AU - Muggia, Franco M.
T1 - Hepatotoxicity of Combination Chemotherapy for Acute Myelocytic Leukemia.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/08//
VL - 87
IS - 2
M3 - Letter
SP - 247
EP - 248
SN - 00034819
AB - Presents a letter to the editor about hepatotoxicity of combination chemotherapy for acute myelocytic leukemia.
KW - LETTERS to the editor
KW - COMBINATION drug therapy
N1 - Accession Number: 14147192; Penta, John S. 1; von Hoff, Daniel D. 1; Muggia, Franco M. 1; Source Information: Aug77, Vol. 87 Issue 2, p247; Subject: LETTERS to the editor; Subject: COMBINATION drug therapy; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Von Hoff, D. D.;
AU - Rozencweig, M.;
AU - Soper, W. T.;
AU - Helman, L. J.;
AU - Penta, J. S.;
AU - \ET/;
T1 - Whatever happened to NSC? An analysis of clinical results of discontinued anticancer agents
CT - Whatever happened to NSC? An analysis of clinical results of discontinued anticancer agents
JO - Cancer Treat. Rep.
JF - Cancer Treat. Rep.
Y1 - 1977/08/01/
VL - 61
IS - Aug
SP - 759
EP - 768
AD - Div. of Cancer Treatment, National Cancer Institute, Building 10, Room 12N226, National Institutes of Health, Bethesda, Maryland 20014
N1 - Accession Number: 14-6374; Language: English; References: 146; Journal Coden: CCYPBY; Section Heading: Investigational Drugs
N2 - Twenty-six investigational anticancer drugs formerly supplied by the National Cancer Institute are no longer available due to the lack of requests for their use in clinical trials. This report examines the data on these drugs to determine how well they were clinically evaluated. Generally, the studies are incomplete, and 34% of the compounds were not studied beyond phase I trials. Clinical pharmacology data were not obtained for most of the drugs. In addition, the information available for drugs that did undergo phase II trials is grossly inadequate and does not permit a confident decision to withdraw them from investigational use. Instances of hints of activity and interesting drug properties are cited to stimulate further study. Finally, a list of compounds scheduled for future termination is given within the framework of this analysis to provoke thought toward obtaining more phase II data before these drugs fall into disuse.
KW - Antineoplastic agents--drugs, investigational--clinical studies, analysis of discontinued INDs, 1975-1976, recommendations;
KW - Drugs, investigational--antineoplastic agents--clinical studies, analysis of discontinued INDs, 1975-1976, recommendations;
KW - Clinical studies--antineoplastic agents--drugs, investigational, analysis of discontinued INDs, 1975-1976, recommendations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Kraemer, Kenneth H.
AU - Weinstein, Gerald D.
T1 - DECREASED THYMIDINE INCORPORATION IN CIRCULATING LEUKOCYTES AFTER TREATMENT OF PSORIASIS WITH PSORALEN AND LONG-WAVE ULTRAVIOLET LIGHT.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/08//
VL - 69
IS - 2
M3 - Article
SP - 211
EP - 214
SN - 0022202X
AB - Tritiated thymidine incorporation, a measure of DNA synthesis, was studied in circulating leukocytes from patients with widespread psoriasis who were being treated with photochemotherapy using oral 8-methoxypsoralen (8-MOP) and high-intensity, long-wave ultraviolet light (UVA). Seven of 13 psoriasis patients treated with photochemotherapy demonstrated a significant (p < 0.05) reduction in leukocyte incorporation of tritiated thymidine immediately after UVA in comparison to incorporation before UVA. None of 10 control subjects treated with UVA alone demonstrated such reduction in leukocyte tritiated thymidine incorporation. Photochemotherapy thus affects circulating blood cells in some patients with psoriasis in addition to its therapeutic effect on epidermal cells. Further investigations are needed to determine the reasons for the differences in susceptibility to inhibition of leukocyte DNA synthesis among patients and the possible long-term consequences of such inhibition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYMIDINE
KW - LEUCOCYTES
KW - PSORALENS
KW - ULTRAVIOLET radiation -- Therapeutic use
KW - PHOTOCHEMOTHERAPY
KW - PSORIASIS
KW - PATIENTS
KW - DNA replication
N1 - Accession Number: 12506316; Kraemer, Kenneth H. 1,2 Weinstein, Gerald D. 2; Affiliation: 1: Department of Dermatology, University of Miami, School of Medicine, Miami, Florida. 2: Chemistry Branch, National Cancer Institute, Bethesda, Maryland, U. S. A.; Source Info: Aug77, Vol. 69 Issue 2, p211; Subject Term: THYMIDINE; Subject Term: LEUCOCYTES; Subject Term: PSORALENS; Subject Term: ULTRAVIOLET radiation -- Therapeutic use; Subject Term: PHOTOCHEMOTHERAPY; Subject Term: PSORIASIS; Subject Term: PATIENTS; Subject Term: DNA replication; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12506316
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TING, C. C.
AU - TSAI, S. C.
AU - ROGERS, M. J.
T1 - Host Control of Tumor Growth.
JO - Science
JF - Science
Y1 - 1977/08/05/
VL - 197
IS - 4303
M3 - Article
SP - 571
EP - 573
SN - 00368075
AB - A humoral factor (molecular weight less than 60,000) that was present in the ascitic fluid of mice bearing intraperitoneal tumors and in pleural effusions from human cancer patients was found to promote the growth of a murine tumor and to suppress cell-mediated tumor immunity. However, the hosts that had recovered from the immunosuppressive state produced a serum factor that could neutralize the immunosuppressive effect. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519195; TING, C. C. 1; TSAI, S. C. 2; ROGERS, M. J. 3; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Cellular Metabolism, National Heart and Lung Institute, Bethesda, Maryland 20014; 3: Laboratory of Cell Biology, National Cancer Institute; Issue Info: 8/5/1977, Vol. 197 Issue 4303, p571; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Slater, S. L.;
AU - Shiling, D. J.;
AU - Lipper, S.;
AU - Murphy, D. L.;
T1 - Elevation of plasma prolactin by monoamine oxidase inhibitors
CT - Elevation of plasma prolactin by monoamine oxidase inhibitors
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1977/08/06/
VL - 2
IS - Aug 6
SP - 275
EP - 276
SN - 00237507
AD - Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20014
N1 - Accession Number: 15-0425; Language: English; Chemical Name: Pargyline--555-57-7; References: 8; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Joan Lentine
N2 - Plasma prolactin levels doubled in 10 depressive patients treated with the monoamine oxidase inhibitors, clorgyline and pargyline. Plasma prolactin levels were measured 4 times\M/twice (4 days apart) after 3 weeks on placebo and twice (4 days apart) after 3 weeks on either clorgyline (20-40 mg/day) or pargyline (75-150 mg/day). Five patients (3 women and 2 men) were studied on each drug. Both medications were given in divided doses, the last dose being no later than 15 hr before a blood sample was taken. The absence of significant changes in plasma cortisol in the same patients suggests that the increases in prolactin are not attributable to nonspecific effects of stress.
KW - Clorgyline--effects-;
KW - Pargyline--effects-;
KW - Monoamine oxidase inhibitors--clorgyline--elevation, plasma prolactin levels, depressive patients;
KW - Monoamine oxidase inhibitors--pargyline--elevation, plasma prolactin levels, depressive patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PAUL, STEVEN M.
AU - AXELROD, JULIUS
T1 - Catechol Estrogens: Presence in Brain and Endocrine Tissues.
JO - Science
JF - Science
Y1 - 1977/08/12/
VL - 197
IS - 4304
M3 - Article
SP - 657
EP - 659
SN - 00368075
AB - Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use ofa sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products. The concentration of catechol estrogens in the hypothalamus and pituitary are at least ten times higher than reported previously for the parent estrogens. Catechol estrogens have potent endocrine effects and, because of their normal occurrence in the hypothalamic-pituitary axis, they may have an important role in neuroendocrine regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87476550; PAUL, STEVEN M. 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 8/12/1977, Vol. 197 Issue 4304, p657; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHULTZ, RICHARD M.
AU - PAPAMATHEAKIS, JOSEPH D.
AU - CHIRIGOS, MICHAEL A.
T1 - Interferon: An Inducer of Macrophage Activation by Polyanions.
JO - Science
JF - Science
Y1 - 1977/08/12/
VL - 197
IS - 4304
M3 - Article
SP - 674
EP - 676
SN - 00368075
AB - Purified mouse fibroblast interferon (IF) directly rendered resting macrophages tumoricidal. The physicochemical properties and species specificity of the stimulatory agent fall within the present definition of IF. Since a number of polyanions induce macrophage IF, the antitumor and antimicrobial activities may result from the ability of newly released IF to modify macrophage activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87476554; SCHULTZ, RICHARD M. 1; PAPAMATHEAKIS, JOSEPH D. 1; CHIRIGOS, MICHAEL A. 1; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/12/1977, Vol. 197 Issue 4304, p674; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHLAGER, SEYMOUR I.
AU - OHANIAN, SARKIS H.
T1 - Correlation Between Lipid Synthesis in Tumor Cells and Their Sensitivity to Humoral Immune Attack.
JO - Science
JF - Science
Y1 - 1977/08/19/
VL - 197
IS - 4305
M3 - Article
SP - 773
EP - 776
SN - 00368075
AB - Prolonged incubation of two antigenically distinct, chemically induced guinea pig hepatomas with relatively high concentrations of chemotherapeutic drugs or metabolic inhibitors increases their susceptibility to killing by antibody and complement. This effect is reversible when the cells are cultured in the absence of the drugs. The drug-induced sensitivity and the ability of the cells to recover their resistance to killing are directly correlated to their ability to synthesize complex lipids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87459886; SCHLAGER, SEYMOUR I. 1; OHANIAN, SARKIS H. 1; Affiliations: 1: Laboratory of Immunobiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/19/1977, Vol. 197 Issue 4305, p773; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FIDLER, ISAIAH J.
AU - KRIPKE, MARGARET L.
T1 - Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor.
JO - Science
JF - Science
Y1 - 1977/08/26/
VL - 197
IS - 4306
M3 - Article
SP - 893
EP - 895
SN - 00368075
AB - Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87476587; FIDLER, ISAIAH J. 1; KRIPKE, MARGARET L. 1; Affiliations: 1: Basic Research Program, National Cancer Institute Frederick Cancer Research Center, Frederick, Maryland 21701; Issue Info: 8/26/1977, Vol. 197 Issue 4306, p893; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bender, J. F.;
AU - Grove, W. R.;
AU - Fortner, C. L.;
T1 - High dose methotrexate with folinic acid rescue
CT - High dose methotrexate with folinic acid rescue
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1977/09/01/
VL - 34
IS - Sep
SP - 962
EP - 965
SN - 00029289
AD - Baltimore Cancer Research Center, National Cancer Institute, NIH, Univ. of Maryland Hosp., Baltimore, Maryland 21201
N1 - Accession Number: 14-5300; Language: English; Chemical Name: Methotrexate--59-05-2 Leucovorin--58-05-9; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; References: 34; Journal Coden: AJHPA9; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A brief review of the pharmacology of methotrexate is presented, and the rationale for the administration of high dose methotrexate and the necessity of a folinic acid (leucovorin) rescue to prevent methotrexate toxicity are discussed. Critical factors concerning the use of this therapy, as well as unusual toxicities associated with the use of high dose methotrexate, are presented. Several drug and patient related variables which may affect the toxicity of this dual drug administration are discussed to better enable pharmacists to monitor patients receiving this form of therapy. High dose methotrexate with folinic acid rescue has improved the therapeutic index of methotrexate. The optimal dosage and duration of the 2 agents are yet to be determined.
KW - Methotrexate--toxicity-;
KW - Leucovorin--prophylaxis-;
KW - Toxicity--methotrexate--prophylaxis, leucovorin rescue, patients;
KW - Antineoplastic agents--methotrexate--toxicity, prophylaxis, leucovorin rescue, patients;
KW - Dosage--methotrexate--high, toxicity, prophylaxis, leucovorin rescue, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Gershengorn, Marvin C.
AU - McClung, Michael R.
AU - Chu, Elizabeth W.
AU - Hanson, Thomas A. S.
AU - Weintraub, Bruce D.
AU - Robbins, Jacob
T1 - Fine-Needle Aspiration Cytology in the Preoperative Diagnosis of Thyroid Nodules.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/09//
VL - 87
IS - 3
M3 - Article
SP - 265
EP - 269
SN - 00034819
AB - Fifty consecutive patients were studied to assess the utility of fine-needle aspiration cytology for the diagnosis of hypofunctioning thyroid nodules. In two patients, cysts were evaculated and did not recur. Thirty-three patients underwent excisional biopsy; the aspiration biopsy result was not a briterion for surgery. Satisfactory aspiration specimens were obtained in 32 patients (97%). The diagnosis in espiration specimens was malignant; of these seven (78%) were correct and there was one false-positive and one occult carcinoma unrelated to the clinically detected nodule. Five aspirations showed suspected malignancy; of these, two were carcinoma, one was an occult carcinoma, and two were benign. Eighteen aspirations were interpreted as benign; of these 17 (94%) were correct and the one false-negative diagnosis was a well-differentiated follicular carcinoma. The procedure is useful in assessing the need for surgery in high-risk patients and in selecting patients for thyroid-suppression therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEEDLE biopsy
KW - PARACENTESIS
KW - THYROID gland
KW - CYTOLOGY
KW - BIOLOGY
KW - CLINICAL pathology
N1 - Accession Number: 14153392; Gershengorn, Marvin C. 1; McClung, Michael R. 1; Chu, Elizabeth W. 1; Hanson, Thomas A. S. 1; Weintraub, Bruce D. 1; Robbins, Jacob 1; Source Information: Sep77, Vol. 87 Issue 3, p265; Subject: NEEDLE biopsy; Subject: PARACENTESIS; Subject: THYROID gland; Subject: CYTOLOGY; Subject: BIOLOGY; Subject: CLINICAL pathology; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Mitchell, Jerry R.
T1 - Host Susceptibility and Acetaminophen Liver Injury.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/09//
VL - 87
IS - 3
M3 - Editorial
SP - 377
EP - 378
SN - 00034819
AB - For most patients and consumers of over-the counter drugs, acetaminophen is safe when used appropriately. It is a good antipyretic, effectively relieves mild and moderate pain, and has minor anti-inflammatory action. In overdosage the drug causes acute centrilobular hepatic necrosis that may be fatal, and acetaminophen poisoning is now one of the commonest causes of hepatic failure in Great Britain. The concentration of hepatic glutathione in various disease, dietary, and therapeutic situations is unknown, and the maximal synthetic capacity and availability of glutathione in human liver for detoxification has not been examined.
KW - LIVER failure
KW - ACETAMINOPHEN
KW - GLUTATHIONE
KW - NECROSIS
KW - PATIENTS
KW - DRUG abuse
N1 - Accession Number: 14154289; Mitchell, Jerry R. 1; Source Information: Sep77, Vol. 87 Issue 3, p377; Subject: LIVER failure; Subject: ACETAMINOPHEN; Subject: GLUTATHIONE; Subject: NECROSIS; Subject: PATIENTS; Subject: DRUG abuse; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - hch
ER -
TY -
AU - Gainer, Ruth Straus1
AU - Gainer, Harold2
T1 - Educating Both Halves of the Brain: Fact or Fancy.
JO - Art Education
JF - Art Education
J1 - Art Education
PY - 1977/09//
Y1 - 1977/09//
VL - 30
IS - 5
CP - 5
M3 - Article
SP - 20
EP - 22
SN - 00043125
AB - The article focuses on the issue concerning the concept of cultivating both halves of the brain to pedagogical practice in the U.S. Educators are urged to balance the students' brains by educating the two hemispheres through various forms of activities relevant to logical and analytical exercises. In an attempt to evaluate the relevance of cerebral lateralization to education, both the educational and neurological literature have been examined. According to the authors, arts provide many possibilities for meeting the desired educational objective.
KW - Art -- Study & teaching
KW - Educational planning
KW - Educational psychology
KW - Cerebral hemispheres
KW - Effective teaching
KW - Educators
KW - Teaching methods
KW - Cerebral dominance
KW - United States
N1 - Accession Number: 28741979; Authors: Gainer, Ruth Straus 1; Gainer, Harold 2; Affiliations: 1: Visual Arts Specialist, Project ARTS, Montgomery County Public Schools, Maryland; 2: Head, Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health And Human Development; Subject: Educational planning; Subject: Educational psychology; Subject: Cerebral hemispheres; Subject: Effective teaching; Subject: Educators; Subject: Art -- Study & teaching; Subject: Teaching methods; Subject: Cerebral dominance; Subject: United States; Number of Pages: 3p; Record Type: Article
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DP - EBSCOhost
DB - asu
ER -
TY - JOUR
AU - Wyler, D. J.
AU - Brown, J.
T1 - Malaria antigen-specific T-cell responsiveness during infection with Plasmodium falciparum.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/09//
VL - 29
IS - 3
M3 - Article
SP - 401
EP - 407
PB - Wiley-Blackwell
SN - 00099104
AB - Protective immunity against Plasmodium falciparum develops only after several years of repeated exposure to the malarial parasite. We therefore investigated the possibility that acute malaria was associated with malarial antigen-specific immunosuppression. Peripheral lymphocytes of West Africans with and without P. falciparum infections were tested fur their in vitro proliferative responses to a preparation of P. falciparum antigen. There was no significant difference between the magnitude of the proliferative response of lymphocytes from infected as compared to normal Africans, although the responses from both African groups were significantly higher than responses from a group of European controls. Furthermore, no soluble inhibitor of antigen- specific proliferation was present in plasma of infected patients. These observations strongly suggest that if the sluggish development of protective immunity in malaria is based upon infection related immunosuppression, this occurs without affecting the proliferative responsiveness of specific sensitized, circulating T cells. Preliminary observations also indicate that Europeans residing in Africa and taking malaria prophylaxis may acquire sensitized T cells without experiencing clinically apparent infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMODIUM falciparum
KW - MALARIA
KW - INFECTION
KW - ANTIGENS
KW - T cells
KW - FEVER
N1 - Accession Number: 16142411; Wyler, D. J. 1 Brown, J. 2; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Medical Research Council Laboratories, Fajara, The Gambia, West Africa; Source Info: Sep1977, Vol. 29 Issue 3, p401; Subject Term: PLASMODIUM falciparum; Subject Term: MALARIA; Subject Term: INFECTION; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: FEVER; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ottesen, E.A.
AU - Weller, P.F.
AU - Heck, L.
T1 - Specific cellular immune unresponsiveness in human filariasis.
JO - Immunology
JF - Immunology
Y1 - 1977/09//
VL - 33
IS - 3
M3 - Article
SP - 413
PB - Wiley-Blackwell
SN - 00192805
AB - Investigates specific cellular immune unresponsiveness in human filariasis. Observation that the poor cellular responsiveness of infected individuals was filaria antigen-specific, as reactivity to tuberculin and streptococcal antigens; Data indicating that a state of antigen-specific cellular unresponsiveness in patients with this chronic parasitic infection and speculate that this immunologic deficit may be of fundamental importance in the pathogenesis of filarial disease.
KW - FILARIASIS
KW - TUBERCULIN
KW - ANTIGENS
N1 - Accession Number: 11179402; Ottesen, E.A. 1 Weller, P.F. 1 Heck, L. 1; Affiliation: 1: Laboratory of Parasitic Diseases and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Sep77, Vol. 33 Issue 3, p413; Subject Term: FILARIASIS; Subject Term: TUBERCULIN; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 83991222
T1 - Sound advice for conducting clinical trials.
AU - Byar, David P.
AU - Byar, D P
Y1 - 1977/09/08/
N1 - Accession Number: 83991222. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: clinical trial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins). NLM UID: 0255562.
KW - Study Design
KW - Therapeutics
KW - Human
KW - Clinical Trials
KW - Statistics
KW - United States
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Scales
SP - 553
EP - 554
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 297
IS - 10
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - National Cancer Institute Bethesda, MD 20014
U2 - PMID: 329129.
DO - 10.1056/NEJM197709082971009
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - SCHWARTZ, WILLIAM J.
AU - GAINER, HAROLD
T1 - Suprachiasmatic Nucleus: Use of 14C-Labeled Deoxyglucose Uptake as a Functional Marker.
JO - Science
JF - Science
Y1 - 1977/09/09/
VL - 197
IS - 4308
M3 - Article
SP - 1089
EP - 1091
SN - 00368075
AB - Glucose consumption of the rat suprachiasmatic nuclei (SCN) was studied under various experimental conditions by means of the [14C]deoxyglucose (DG) technique. The results show that glucose consumption of the SCN, in contrast to other brain structures, is a function of both the time of day and environmental lighting conditions. These data are consistent with the hypothesis that the SCN have an essential role in circadian rhythm regulation and indicate that the DG technique may provide a novel approach for the study of the central neural mechanisms underlying circadian rhythm regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87476671; SCHWARTZ, WILLIAM J. 1; GAINER, HAROLD 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda 20014; Issue Info: 9/9/1977, Vol. 197 Issue 4308, p1089; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hoover, R.;
AU - Gray, L. A.;
AU - Fraumeni, J. F.;
T1 - Stilbestrol (diethylstilbestrol) and the risk of ovarian cancer
CT - Stilbestrol (diethylstilbestrol) and the risk of ovarian cancer
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1977/09/10/
VL - 2
IS - Sep 10
SP - 533
EP - 534
SN - 00237507
AD - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014
N1 - Accession Number: 15-0956; Language: English; Trade Name: Premarin; Generic Name: Estrogenic substances; Chemical Name: Diethylstilbestrol--56-53-1; References: 12; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Interactions
N2 - A follow-up survey of 908 women who had received Premarin (conjugated equine estrogen) for menopausal symptoms revealed 9 cases of ovarian cancer. This risk was 2 to 3 times greater than expected. The risk increased with the strength of Premarin tablet usually taken, but not with the duration of use or total dose ingested. The excess risk of ovarian cancer in this group occurred primarily among 21 women who had also used diethylstilbestrol. The results of this small trial are consistent with the increasing incidence of ovarian cancer in American postmenopausal women, and with the occurrence of stilbestrol induced ovarian neoplasms in dogs.
KW - Diethylstilbestrol--toxicity-;
KW - Estrogenic substances--conjugated--toxicity, studies, ovarian cancer, patients who had also taken diethylstilbestrol;
KW - Toxicity--estrogenic substances--conjugated, studies, ovarian cancer, patients who had also taken diethylstilbestrol;
KW - Toxicity--diethylstilbestrol--studies, ovarian cancer, patients who had also taken estrogenic substances, conjugated;
KW - Drug interactions--estrogenic substances, conjugated and diethylstilbestrol--possible, ovarian cancer, patients;
KW - Drug interactions--diethylstilbestrol and estrogenic substances, conjugated--possible, ovarian cancer, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - STEPHEN, E. L.
AU - HILMAS, D. E.
AU - MANGIAFICO, J. A.
AU - LEVY, H. B.
T1 - Swine Influenza Virus Vaccine: Potentiation of Antibody Responses in Rhesus Monkeys.
JO - Science
JF - Science
Y1 - 1977/09/23/
VL - 197
IS - 4310
M3 - Article
SP - 1289
EP - 1290
SN - 00368075
AB - Polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose [poly(ICLC)] enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. Monkeys given the vaccine-adjuvant combination had earlier and significantly (P < .05) higher titers by 14 days compared to those that received vaccine alone. The potentiation of the antibody response of young monkeys given a split-virus vaccine in combination with poly(ICLC) suggests that this vaccine-adjuvant combination may similarly provide a potentially useful alternative approach to the immunization of pediatric and young adult age groups against swine influenza. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87459924; STEPHEN, E. L. 1; HILMAS, D. E.; MANGIAFICO, J. A. 1; LEVY, H. B. 2; Affiliations: 1: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 9/23/1977, Vol. 197 Issue 4310, p1289; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parlin, Leonard I.
AU - Johnson, Joyce S.
T1 - MARITAL STATUS, LIFE-STRAINS AND DEPRESSION.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1977/10//
VL - 42
IS - 5
M3 - Article
SP - 704
EP - 715
SN - 00031224
AB - The relationship between marital status and psychological distress, consistently documented by a variety of studies, traditionally has been interpreted as reflecting the unmet inner needs and emotional frustrations of never married and formerly married people. In contrast, the present study examines the depressive consequences of economic hardship, social isolation and parental responsibilities as three durable, structured conditions of life to which unmarried people are both more exposed and more vulnerable. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MARITAL status
KW - DISTRESS (Psychology)
KW - SOCIAL isolation
KW - MARRIAGE
KW - EMOTIONS (Psychology)
KW - SOCIAL psychology
N1 - Accession Number: 14764148; Parlin, Leonard I. 1; Johnson, Joyce S. 2; Affiliations: 1: National Institute of Mental Health.; 2: U. S. Department of Labor.; Issue Info: Oct77, Vol. 42 Issue 5, p704; Subject Term: MARITAL status; Subject Term: DISTRESS (Psychology); Subject Term: SOCIAL isolation; Subject Term: MARRIAGE; Subject Term: EMOTIONS (Psychology); Subject Term: SOCIAL psychology; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Langley, Charles H.
T1 - A LITTLE DARWINISM….
JO - BioScience
JF - BioScience
Y1 - 1977/10//
VL - 27
IS - 10
M3 - Book Review
SP - 692
EP - 692
SN - 00063568
AB - The article reviews the book "The Selfish Gene," by Richard Dawkins.
KW - Evolution (Biology)
KW - Fiction
KW - Dawkins, Richard, 1941-
KW - Selfish Gene, The (Book)
N1 - Accession Number: 28049918; Langley, Charles H. 1; Affiliations: 1 : National Institute of Environmental Health Sciences, Laboratory of Environmental, Mutagenesis Research, Triangle Park, NC 27709; Source Info: Oct1977, Vol. 27 Issue 10, p692; Thesaurus Term: Evolution (Biology); Subject Term: Fiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 354
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
TY - GEN
AU - Bender, R. A.;
AU - Castle, M. C.;
AU - Margileth, D. A.;
AU - Oliverio, V. T.;
T1 - Pharmacokinetics of (\SU/3\BS/H)-vincristine in man
CT - Pharmacokinetics of (\SU/3\BS/H)-vincristine in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1977/10/01/
VL - 22
IS - Oct
SP - 430
EP - 438
SN - 00099236
AD - Med. Branch and Office of the Director for Experimental Therapeutics, National Cancer Institute, 9000 Rockville Pike, Bldg. 10, Rm. 12N226, Bethesda, MD 20014
N1 - Accession Number: 15-1581; Language: English; Chemical Name: Vincristine--57-22-7; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents vincristine; References: 11; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - The pharmacokinetics, metabolism, and excretion of aromatically labeled tritiated vincristine (I) were examined in 4 patients. Clearance of radioactivity from the blood was triphasic with half-life t1/2 values of 0.85, 7.4, and 164 min. The initial phases probably represent distribution and binding to formed blood elements which exceeded 50% of the administered dose by 20 min. Excretion of radioactivity was principally fecal, with 33% recovered in the feces by 24 hr and 69% by 72 hr. Considerably less radioactivity (12%) was excreted in the urine over the 72 hr period. Approximately 40% of fecally excreted and 46% of urinary excreted radiolabel represented metabolites, which suggests that at least 34% of the I dose was excreted as metabolites. Plasma metabolites represented from less than one percent to 30% or more of radioactivity in plasma. UV spectral analysis of all metabolites revealed preservation of the intact I dimer, which suggests that metabolism involves alteration of side groups.
KW - Vincristine--pharmacokinetics-;
KW - Pharmacokinetics--vincristine--blood levels, and excretion, patients;
KW - Excretion--vincristine--urinary, patients;
KW - Half-life--vincristine--blood levels, patients;
KW - Blood levels--vincristine--half-life, patients;
KW - Antineoplastic agents--vincristine--pharmacokinetics, patients;
KW - Drugs, body distribution--vincristine--pharmacokinetics, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Korts, David C.
T1 - Analysis of caries clinical trial data in the presence of study group imbalance.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1977/10//
VL - 5
IS - 5
M3 - Article
SP - 231
EP - 236
SN - 03015661
AB - Imbalance of any important factor in caries clinical trials can bias group means, and make decisions based on such means of questionable value. Six hypothetical trials are presented which have varying degrees of imbalance in baseline DMFS. The crude group means for these trials vary radically, from one extreme in which tile treated group has significantly less decay than the control group, to the opposite extreme in which the control group has significantly less decay than the treated group. Two methods for adjustment to correct for the imbalances, the analysis of covariance and blocking analysis, are discussed and applied to each trial. For these data sets the blocking analysis appears superior to the analysis of covariance in terms of maintaining the essential character of the data. An appendix explaining in detail how the blocking analysis is performed can be obtained on request to the author. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries
KW - CLINICAL trials
KW - RESEARCH
KW - CLINICAL medicine -- Research
KW - METHODOLOGY
KW - DENTAL pathology
KW - clinical trial
KW - dental caries
N1 - Accession Number: 12105185; Korts, David C. 1; Affiliation: 1: Biometry Section, National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct1977, Vol. 5 Issue 5, p231; Subject Term: DENTAL caries; Subject Term: CLINICAL trials; Subject Term: RESEARCH; Subject Term: CLINICAL medicine -- Research; Subject Term: METHODOLOGY; Subject Term: DENTAL pathology; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: dental caries; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12105185
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oxambra, Leonard M.
T1 - INDEPENDENT DIMENSIONS OF DEPRESSION: A FACTOR ANALYSIS OF THREE SELF-REPORT DEPRESSION MEASURES.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1977/10//
VL - 33
IS - 4
M3 - Article
SP - 928
EP - 935
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - Covariance studies of objective depression measures have concentrated on total scores. This approach is relatively insensitive in specifying whether these instruments measure the same sub-aspects of depression. To investigate this question, a factor analysis was performed on the items of the Beck Depression Inventory and the Zung Self-Rating Depression Scale and lists .A, B, C, and D of the Lubin Depression Adjective Check Lists. Ss were 91 college students and 29 correctional institution inmates. Four clearly interpretable multimeasure factors resulted from a Varimax rotation. The most salient factor was labeled "Depression: Affective Malaise." Earlier studies also have shown this to be a dominant and reliable dimension of depression. The other factors were: "Suicidal Ambivalence," "Appetite-Weight Loss," and "Fatigability." Females showed greater Fatigability associated with depression. Factors specific to the Beck and Zung measures also were found, which suggests that the different emphases of these instruments, intensity/severity vs. frequency of symptoms, may contribute very specific depression indicators. This may indicate that both intensity and frequency of symptoms ought to be considered to obtain a "best" objective measure of depression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression
KW - MENTAL depression -- Diagnosis
KW - CLINICAL psychology
KW - PSYCHOLOGICAL tests
N1 - Accession Number: 15866684; Oxambra, Leonard M. 1; Affiliation: 1: National Institute on Aging Baltimore, Maryland; Source Info: Oct1977, Vol. 33 Issue 4, p928; Subject Term: MENTAL depression; Subject Term: MENTAL depression -- Diagnosis; Subject Term: CLINICAL psychology; Subject Term: PSYCHOLOGICAL tests; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BLOT, WILLIAM J.
AU - BRINTON, LOUISE A.
AU - FRAUMENI, JR., JOSEPH F.
AU - STONE, B. J.
T1 - Cancer Mortality in U.S. Counties with Petroleum Industries.
JO - Science
JF - Science
Y1 - 1977/10/07/
VL - 198
IS - 4312
M3 - Article
SP - 51
EP - 53
SN - 00368075
AB - A survey of cancer mortality from 1950 to 1969 was conducted in U.S. counties where the petroleum industry is most heavily concentrated. Male residents of these counties experienced significantly higher rates for cancers of the lung, the nasal cavity and sinuses, and the skin (including malignant melanoma) compared to male residents ofcounties with similar demographic characteristics. Further study is needed to determine whether these patterns result from exposure to chemical carcinogens, including polycyclic hydrocarbons, involved in the manufacturing of petroleum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87459981; BLOT, WILLIAM J. 1; BRINTON, LOUISE A. 1; FRAUMENI, JR., JOSEPH F. 1; STONE, B. J. 1; Affiliations: 1: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/7/1977, Vol. 198 Issue 4312, p51; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Claxton, Larry D.
AU - Barry, Patricia Z.
T1 - Chemical Mutagenesis: An Emerging Issue For Public Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/11//
VL - 67
IS - 11
M3 - Article
SP - 1037
PB - American Public Health Association
SN - 00900036
AB - Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENS
KW - MUTAGENESIS
KW - MUTATION (Biology)
KW - PUBLIC health
KW - TEST systems
KW - TEST methods
KW - FEDERAL regulation
KW - DELEGATED legislation
KW - FEDERAL government
N1 - Accession Number: 5662300; Claxton, Larry D. 1 Barry, Patricia Z. 2; Affiliation: 1: Biologist, National Institute of Environmental Health Sciences, Research Triangle Park, NC 2: Assistant Professor, Department of Health Administration, UNC School of Public Health, Chapel Hill, NC 27514; Source Info: Nov77, Vol. 67 Issue 11, p1037; Subject Term: MUTAGENS; Subject Term: MUTAGENESIS; Subject Term: MUTATION (Biology); Subject Term: PUBLIC health; Subject Term: TEST systems; Subject Term: TEST methods; Subject Term: FEDERAL regulation; Subject Term: DELEGATED legislation; Subject Term: FEDERAL government; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahmed, A.
AU - Smith, A.H.
AU - Sell, K.W.
AU - Gershwin, M.E.
AU - Steinberg, A.D.
AU - Thurman, G.B.
AU - Goldstein, A.L.
T1 - Thymic-dependent anti-hapten response in congenitally athymic (nude) mice immunized with DNP-thymosin.
JO - Immunology
JF - Immunology
Y1 - 1977/11//
VL - 33
IS - 5
M3 - Article
SP - 757
PB - Wiley-Blackwell
SN - 00192805
AB - Reports on the finding that immunization of congenitally athymic (nu/nu) and adult thymectomized, irradiated bone marrow, reconstituted (TxBm) mice with DNP[sub 5]-thymosin, elicited immunoglobulin (Ig)M and IgG anti-DNP plaque-forming cells in the animals. Function of DNP-thymosin both as a hormone and as a T-dependent antigen in eliciting an immune response in nu/nu and TcBm mice.
KW - BONE marrow
KW - THYMOSIN
KW - IMMUNOGLOBULIN M
KW - IMMUNOGLOBULIN G
N1 - Accession Number: 11185159; Ahmed, A. 1 Smith, A.H. 1 Sell, K.W. 1 Gershwin, M.E. 2 Steinberg, A.D. 3 Thurman, G.B. 4 Goldstein, A.L. 4; Affiliation: 1: Cellular Immunology Division, Department of Clinical and Experimental Immunology, Naval Medical Research Institute, Maryland 2: Section of Rheumatology, Department of Internal Medicine, School of Medicine, University of California 3: Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Maryland 4: Division of Biochemistry, University of Texas Medical Branch; Source Info: Nov77, Vol. 33 Issue 5, p757; Subject Term: BONE marrow; Subject Term: THYMOSIN; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNOGLOBULIN G; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peck, Gary L.
AU - Elias, Peter M.
AU - Wetzel, Bruce
T1 - EFFECTS OF RETINOIC ACID ON EMBRYONIC CHICK SKIN.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/11//
VL - 69
IS - 5
M3 - Article
SP - 463
EP - 476
SN - 0022202X
AB - The influence of vitamin A on differentiating epithelia was examined in explants of skin from 14-day chick embryos exposed to retinoic acid (RA) in low, moderate, and high doses. The changes observed in RA-treated cultures are both dose- and time-dependent and are reversible when explants are transferred to control medium. The periderm sloughs prematurely and horizontal stratification is lost. Keratinization is inhibited and fewer desmosomes and tonofilaments are seen. Surface epidermal cells develop microvilli, bulge upwards, and detach. Golgi elements, rough endoplasmic reticulum, and polyribosomes are unusually prominent. Mucin granules form and gland-like structures develop with intercellular canaliculi characterized by tight junctions, brush borders, and dense secretory contents. On the basis of present evidence there are several possible mechanisms by which RA could alter epidermal differentiation. RA-induced gaps in the basal lamina allow direct contact between epidermal basal cells and fibroblasts and collagen fibers which could result in inappropriate dermal signals reaching the epidermis. In younger embryos the entire epidermis, including the mitotically inactive surface cells, appears to respond to RA, and this could imply an epigenetic modulation of cell phenotype. Finally, after the formation of a stratum corneum in older embryos only the relatively undifferentiated basal layer shows a metaplastic response. indicating that RA could be acting directly on the genome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN A
KW - EPITHELIUM
KW - TRETINOIN
KW - CHICKEN embryos
KW - SKIN
KW - KERATINIZATION
N1 - Accession Number: 12511354; Peck, Gary L. 1 Elias, Peter M. 2 Wetzel, Bruce 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland U.S.A.. 2: Department of Dermatology, University of California, Medical Center, San Francisco, California, U.S.A..; Source Info: Nov77, Vol. 69 Issue 5, p463; Subject Term: VITAMIN A; Subject Term: EPITHELIUM; Subject Term: TRETINOIN; Subject Term: CHICKEN embryos; Subject Term: SKIN; Subject Term: KERATINIZATION; Number of Pages: 14p; Document Type: Article
L3 - 10.1111/1523-1747.ep12511354
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KOSLOW, STEPHEN H.
AU - BUTLER, IAN J.
T1 - Biogenic Amine Synthesis Defect in Dihydropteridine Reductase Deficiency.
JO - Science
JF - Science
Y1 - 1977/11/04/
VL - 198
IS - 4316
M3 - Article
SP - 522
EP - 523
SN - 00368075
AB - In the enzymatic hydroxylation of aromatic amino acids, tetrahydrobiopterin is the essential cofactor. Regeneration of tetrahydrobiopterin requires dihydropteridine reductase, without which there should be a deficiency of hydroxylated amino acids and their products, biogenic amines. Assay of biopsied brain cortex of a patient with a deficiency of dihydropteridine reductase showed low concentrations of serotonin and dopamine, and this was reflected in the concentrations of their major metabolites measured in cerebrospinalfluidfrom lumbar, ventricular, and subarachnoid spaces. The metabolite concentrations were restored to normal, or above normal, by treatment with specific-amino acids which bypass the metabolic block at the hydroxylation step. It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460689; KOSLOW, STEPHEN H. 1; BUTLER, IAN J. 2; Affiliations: 1: National Institute of Mental Health, Laboratory of Preclinical Pharmacology, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Issue Info: 11/4/1977, Vol. 198 Issue 4316, p522; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROWE, WALLACE P.
T1 - Recombinant DNA Guidelines: Scientific and Political Questions.
JO - Science
JF - Science
Y1 - 1977/11/11/
VL - 198
IS - 4317
M3 - Article
SP - 563
EP - 564
SN - 00368075
N1 - Accession Number: 87460728; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, Maryland 20014; Issue Info: 11/11/1977, Vol. 198 Issue 4317, p563; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stone, Peter R.
AU - Lorimer III, Wishard S.
AU - Kidwell, William R.
T1 - Properties of the Complex between Histone H1 and Poly(ADP-ribose) Synthesised in HeLa Cell Nuclei.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1977/11/15/
VL - 81
IS - 1
M3 - Article
SP - 9
EP - 18
PB - Wiley-Blackwell
SN - 00142956
AB - Preparations of H1 histone from HeLa cell nuclei incubated with [³H]NA D to permit poly(A DP-ribose) synthesis were electrophoresed on polyacrylamide gels. The incorporated radioactivity migrated as a sharply defined peak in association with a protein band which moved more slowly than HI, the major protein component. The following observations indicate that this complex is composed of two molecules of H1 and a single chain of poly(ADP-ribose) with one detectable covalent linkage of polymer to protein. 1. The [14]arginine/[³H]lysine ratio is identical m H1 histone and in the protein moiety of the complex. 2. Protein is displaced from H1 histone to the complex during poly(ADP-ribose) synthesis. At least 90% of the protein in the complex (stainable protein and labelled protein) is derived from H1. 3. Sedimentation rate studies indicate a molecular weight of the complex about twice that of H1 histone. 4. The average chain length of the polymer is 15 ADP-ribose units and there are 7–8 ADP-ribose units for each molecule of H1 histone in the ‘complex’ 5. Poly(ADP-ribose) glycohydrolase, which hydrolyses the polymer exoglycosidically from the AMP terminus, degrades the complex producing ADP-ribose and mono-ADP-ribosylated H1 histone which co-electrophoreses with unmodified H1. Although only one covalent linkage between protein and polymer has been detected, the ‘complex’ does not dissociate when electrophoresed on dodecylsulfate gels. Nor can the non-covalently linked H histone of the complex readily exchange with free H1. Complex formation does not occur when purified poly(ADP-ribose) and H1 are mixed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTONES
KW - ADENOSINE diphosphate
KW - RIBOSE
KW - HELA cells
KW - CELL nuclei
KW - POLYACRYLAMIDE gel electrophoresis
KW - MOLECULAR weights
N1 - Accession Number: 13489277; Stone, Peter R. 1 Lorimer III, Wishard S. 1 Kidwell, William R. 1; Affiliation: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland; Source Info: 11/15/77, Vol. 81 Issue 1, p9; Subject Term: HISTONES; Subject Term: ADENOSINE diphosphate; Subject Term: RIBOSE; Subject Term: HELA cells; Subject Term: CELL nuclei; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: MOLECULAR weights; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GRUBBS, CLINTON J.
AU - MOON, RICHARD C.
AU - SQUIRE, ROBERT A.
AU - FARROW, GEORGE M.
AU - STINSON, SHERMAN F.
AU - GOODMAN, DAWN G.
AU - BROWN, CHARLESC.
AU - SPORN, MICHAEL B.
T1 - 13-cis-Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
JO - Science
JF - Science
Y1 - 1977/11/18/
VL - 198
IS - 4318
M3 - Article
SP - 743
EP - 744
SN - 00368075
AB - Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436456; GRUBBS, CLINTON J. 1; MOON, RICHARD C. 1; SQUIRE, ROBERT A. 2; FARROW, GEORGE M. 3; STINSON, SHERMAN F. 4; GOODMAN, DAWN G. 4; BROWN, CHARLESC. 4; SPORN, MICHAEL B. 4; Affiliations: 1: IIT Research Institute, Chicago, Illinois 60616; 2: Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 3: Mayo Clinic, Rochester, Minnesota 55901; 4: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 11/18/1977, Vol. 198 Issue 4318, p743; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JACQUET, YASUKo F.
AU - KLEE, WERNER A.
AU - RICE, KENNER C.
AU - IIJIMA, IKUO
AU - MINAMIKAWA, JUNICHI
T1 - Stereospecific and Nonstereospecific Effects of (+)- and (-)- Morphine: Evidence for a New Class of Receptors?
JO - Science
JF - Science
Y1 - 1977/11/25/
VL - 198
IS - 4319
M3 - Article
SP - 842
EP - 845
SN - 00368075
AB - The unnatural (+) enantiomer of morphine had minimal activity in three opiate assays in vitro: the rat brain homogenate binding assay, the electrically stimulated guinea pig ileum assay, and the inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cell homogenates. When (+)-morphine was microinjected into the periaqueductal gray (a site known to mediate morphine analgesia) of drugnaive rats, there was only minimal analgesia, but the hyperresponsivity usually observed after microinjection of(-)-morphine occurred. Also, when (+)-morphine was microinjected into the midbrain reticularformation of drug-naive rats, rotation similar to that following microinjection of(-)-morphine occurred. These behaviors were not blocked by naloxone. Significantly, they typically occur in precipitated abstinence in morphine-dependent rats. These observations suggest that there are at least two classes of receptors, one stereospecific and blocked by naloxone and the other only weakly stereospecific and not blocked by naloxone, and that precipitated abstinence may be due, in part, to a selective blockade of receptors of the former class but not of the latter. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268553; JACQUET, YASUKo F. 1; KLEE, WERNER A. 2; RICE, KENNER C. 3; IIJIMA, IKUO 3; MINAMIKAWA, JUNICHI 3; Affiliations: 1: New York State Research Institute for Neurochemistry and Drug Addiction, Rockland Psychiatric Institute, Ward's Island 10035; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; Issue Info: 11/25/1977, Vol. 198 Issue 4319, p842; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weisberg, Robert A.
AU - Adhya, Sankar
T1 - ILLEGITIMATE RECOMBINATION IN BACTERIA AND BACTERIOPHAGE.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1977/12//
VL - 11
M3 - Article
SP - 451
EP - 473
PB - Annual Reviews Inc.
SN - 00664197
AB - Presents a study on the illegitimate recombination in bacteria and bacteriophage. Characteristics of transducing phage formation on Phage X; Identification of the deletion mutants in procaryotes; Use of the term illegitimate recombination to describe certain chromosomal rearrangements.
KW - GENETIC recombination
KW - BACTERIA
KW - MUTATION (Biology)
KW - CHROMOSOMES
N1 - Accession Number: 11911701; Weisberg, Robert A. 1 Adhya, Sankar 2; Affiliation: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Halth, Bethesda, Maryland 20014 2: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Source Info: 1977, Vol. 11, p451; Subject Term: GENETIC recombination; Subject Term: BACTERIA; Subject Term: MUTATION (Biology); Subject Term: CHROMOSOMES; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mock, Michael B.
T1 - Rehabilitation of the elderly cardiac patient hampered by bias.
JO - Geriatrics
JF - Geriatrics
Y1 - 1977/12//
VL - 32
IS - 12
M3 - Article
SP - 22
EP - 23
SN - 0016867X
N1 - Accession Number: 17239146; Mock, Michael B. 1; Source Information: Dec1977, Vol. 32 Issue 12, p22; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 959
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Parrillo, J. E.
AU - Fauci, A. S.
T1 - Apparent direct cellular cytotoxicity mediated via cytophilic antibody.
JO - Immunology
JF - Immunology
Y1 - 1977/12//
VL - 33
IS - 6
M3 - Article
SP - 839
EP - 850
PB - Wiley-Blackwell
SN - 00192805
AB - Guinea-pigs immunized with chicken red blood cells (CRBC) developed cytotoxic effector cells in peripheral blood, spleen, lymph nodes, bone marrow and peritoneal exudate cells. Although it appeared that direct cytotoxicity was the mechanism of killing in this model, the true mechanism of cytotoxicity was in fact cytophilic antibody firmly bound to the effector cell rendering it specifically cytotoxic to the CRBC targets. Using multiple cell separation procedures, we demonstrated at least three distinct effector cell populations capable of mediating cytotoxicity in this model: a monocyte-macrophage, a non-phagocytic lymphocyte and a neutrophil, all bearing Fc receptors for Ig. Cell free eluates produced from immune effector cells were capable of rendering non-immune cells of all three Fc receptor bearing leucocyte classes cytotoxic. It is noteworthy that several techniques commonly employed to deplete effector cell populations were shown also to remove cytophilic antibody from the surface of these effector cells. If this had not been recognized, the cytophilic antibody component of the system would have been overlooked and erroneous conclusions would have been made as to which cell populations were functioning as effectors. Recent clinical studies have demonstrated a direct cytotoxicity by K lymphocytes—the usual effector cells in antibody dependent cellular cytotoxicity. The present study suggests that in at least some of these cases true direct cytotoxicity may not be the mechanism of killing and that K cells bearing cytophilic antibody may in fact be the effector cell operating by antibody dependent cellular cytotoxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - IMMUNOGLOBULINS
KW - KILLER cells
KW - LEUCOCYTES
KW - ERYTHROCYTES
KW - ANIMAL models in research
N1 - Accession Number: 11215534; Parrillo, J. E. 1 Fauci, A. S. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Dec77, Vol. 33 Issue 6, p839; Subject Term: CELL-mediated cytotoxicity; Subject Term: IMMUNOGLOBULINS; Subject Term: KILLER cells; Subject Term: LEUCOCYTES; Subject Term: ERYTHROCYTES; Subject Term: ANIMAL models in research; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaoita, Hideo
AU - Katz, Stephen I.
T1 - CIRCULATING IgA ANTI-BASEMENT MEMBRANE ZONE ANTIBODIES IN DERMATITIS HERPETIFORMIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/12//
VL - 69
IS - 6
M3 - Article
SP - 558
EP - 560
SN - 0022202X
AB - Circulating anti-basement membrane zone antibodies of the IgA class were detected in the sera of 2 or 6 dermatitis herpetiformis (DH) patients who had linear in-vivo-bound IgA deposits and in I of 42 DH patients who had granular in vivo-bound IgA deposits. In the former 2 patients the circulating antibodies were localized ultrastructurally to the identical site where the in vivo-bound antibodies were localized and were bound by antigens in either the lamina lucida or the subbasal lamina anchoring fibril area of the basement membrane zone of normal human skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN A
KW - BASAL lamina
KW - DERMATITIS herpetiformis
KW - HUMAN anatomy
KW - IMMUNOGLOBULINS
KW - IGA glomerulonephritis
N1 - Accession Number: 12688382; Yaoita, Hideo 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A.; Source Info: Dec77, Vol. 69 Issue 6, p558; Subject Term: IMMUNOGLOBULIN A; Subject Term: BASAL lamina; Subject Term: DERMATITIS herpetiformis; Subject Term: HUMAN anatomy; Subject Term: IMMUNOGLOBULINS; Subject Term: IGA glomerulonephritis; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12688382
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gail, Mitchell
AU - Mantel, Nathan
T1 - Counting the Number of rxc Contingency Tables with Fixed Margins.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1977/12//
VL - 72
IS - 360
M3 - Article
SP - 859
SN - 01621459
AB - Exact and approximate methods are given for counting the number of r X c contingency tables with fixed margins. The approximate methods are extended to estimate the number of r X c X s contingency tables with given first-order margins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MARGINS (Futures trading)
KW - MATHEMATICAL statistics
KW - STATISTICAL hypothesis testing
KW - APPROXIMATION theory
KW - DISTRIBUTION (Probability theory)
KW - PROBABILITY theory
KW - CONTINGENCY tables
KW - INTEGRALS
KW - CHARACTERISTIC functions
KW - Enumeration of arrays with liked margins
KW - Exact conditional tests on contingency tables
KW - Systems of equations in nonnegative integers.
N1 - Accession Number: 4613926; Gail, Mitchell 1; Mantel, Nathan 2; Affiliations: 1: Medical Statistical Researcher at the Biometry Branch, National Cancer Institute, Landow Building C509, Bethesda, MD 20014.; 2: Research Professor at George Washington University, 7979 Old Georgetown Road, Bethesda, MD 20014.; Issue Info: Dec77, Vol. 72 Issue 360, p859; Thesaurus Term: MARGINS (Futures trading); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: CONTINGENCY tables; Subject Term: INTEGRALS; Subject Term: CHARACTERISTIC functions; Author-Supplied Keyword: Enumeration of arrays with liked margins; Author-Supplied Keyword: Exact conditional tests on contingency tables; Author-Supplied Keyword: Systems of equations in nonnegative integers.; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2006-06293-038
AN - 2006-06293-038
AU - Achenbach, Thomas M.
T1 - The Developmental Psychopathology of Adult Psychosis: A Freudian Version.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1977/12//
VL - 22
IS - 12
SP - 922
EP - 923
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06293-038. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Achenbach, Thomas M.; Laboratory of Developmental Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061113. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Psychology; Developmental Stages; Psychopathology; Psychosis. Minor Descriptor: Childhood Development. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Freeman, Thomas. Childhood Psychopathology and Adult Psychoses=New York: International Universities Press, 1976. Pp. xii + 293. $16.50; 1976. Page Count: 2. Issue Publication Date: Dec, 1977.
AB - Reviews the book, Childhood Psychopathology and Adult Psychoses by Thomas Freeman (see record [rid]1976-12392-000[/rid]). The objective is to demonstrate that the phenomena of adult psychoses can be classified according to their similarities with childhood functioning portrayed in terms of developmental lines and the Developmental Profile. The book is of an unabashedly Freudian lineage. First, it is heavily buttressed with quotations from Freud, both Anna and Sigmund. Second, little heed is paid to relevant nonpsychoanalytic work. Third, it consist exclusively of the author's reports of his own cases. These cases are all adults, and the only data on children are excerpts from psychoanalytic case histories written by others. No data are provided to longitudinally link anything about particular children with later psychosis, even an a correlational fashion, much less to demonstrate causation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developmental psychopathology
KW - adult psychosis
KW - Freudian version
KW - 1977
KW - Child Psychology
KW - Developmental Stages
KW - Psychopathology
KW - Psychosis
KW - Childhood Development
KW - 1977
U2 - Freeman, Thomas. (1976); Childhood Psychopathology and Adult Psychoses; New York: International Universities Press, 1976. Pp. xii + 293. $16.50
DO - 10.1037/015631
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17572-003
AN - 2007-17572-003
AU - Gewirtz, Jacob L.
AU - Boyd, Elizabeth F.
T1 - Does maternal responding imply reduced infant crying? A critique of the 1972 Bell and Ainsworth Report.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1977/12//
VL - 48
IS - 4
SP - 1200
EP - 1207
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
AD - Gewirtz, Jacob L., NIMH Laboratory of Developmental Psychology, National Institutes of Health, Building 15K, Bethesda, MD, US, 20014
N1 - Accession Number: 2007-17572-003. PMID: 608354 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Gewirtz, Jacob L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Crying; Individual Differences; Mother Child Relations. Classification: Social Psychology (3000). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Dec, 1977.
AB - An examination was made of the published rank correlations (p's) from which Bell and Ainsworth (see record [rid]1973-11043-001[/rid]) concluded that mothers who responded more consistently and promptly to their infants' crying in earlier quarters of the first year had infants who cried less often and long in later quarters of that year. Technical limitations critically restrict interpretations of those p's: (a) intercorrelations were of intrinsically contingent measures; (b) the overlapping, dependent intercorrelations were correlated within and between matrices, with unknown Type I error levels; and (c) there were no statistical controls for likely antecedent and concurrent determinants of the 2 outcome-variable sets. Apart from these technical concerns, Bell and Ainsworth's assumption that maternal responding to crying is the inverse of maternal ignoring of crying and their main conclusions from the between-quarter correlations that depended on it were questioned on the bases of (a) the defined independence between the maternal responding and ignoring variables, (b) the positive within-quarter pattern of correlation between them, and (c) the failure to present between-quarter correlations between maternal responding and infant crying. At the same time, Bell and Ainsworth's data were remote from the level of detail required by an operant-learning account (to which, nevertheless, many have referred them). Under such a learning account, various outcomes would be plausible, including the outcome Bell and Ainsworth emphasized. It was concluded that Bell and Ainsworth's main conclusion, that maternal responding implied a reduction in infant crying, was not supported by their data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal response consistency & promptness
KW - decline frequency & duration of infant crying
KW - infant-mother pairs
KW - 1977
KW - Crying
KW - Individual Differences
KW - Mother Child Relations
KW - 1977
DO - 10.2307/1128476
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17572-005
AN - 2007-17572-005
AU - Gewirtz, Jacob L.
AU - Boyd, Elizabeth F.
T1 - In reply to the rejoinder to our critique of the 1972 Bell and Ainsworth Report.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1977/12//
VL - 48
IS - 4
SP - 1217
EP - 1218
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
AD - Gewirtz, Jacob L., NIMH Laboratory of Developmental Psychology, National Institutes of Health, Building 15K, Bethesda, MD, US, 20014
N1 - Accession Number: 2007-17572-005. Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Gewirtz, Jacob L.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Crying; Individual Differences; Mother Child Relations. Classification: Social Psychology (3000). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Dec, 1977.
AB - Reply to the rejoinder by Ainsworth and Bell (see record [rid]2007-17572-004[/rid]) to the critique of Gewirtz and Boyd (see record [rid]2007-17572-003[/rid]) on the original article by Bell and Ainsworth (see record [rid]1973-11043-001[/rid]) about infant crying and maternal responsiveness. Ainsworth and Bell have assumed mistakenly that we intended to denigrate their paradigm or enter a cross-paradigm controversy, despite our circumscribed objectives as stated at the outset of our critique. Bell and Ainsworth's primary conclusion was based on the analysis and interpretation of the relationship between measures of maternal unresponsiveness and infant crying. Therefore our critique focuses on this analysis and interpretation. Our concern with their use of the measure of maternal unresponsiveness was not that it was inherently faulty and should not have been used. Our concern with Bell and Ainsworth's statistical analysis was not that they used non-parametric statistics instead of cross-lag procedures. It was that they neither acknowledged that statistical controls for apparent artifacts were required nor qualified the interpretations of their analyses for the absence of those controls. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal response consistency & promptness
KW - frequency & duration of infant crying
KW - infant-mother pairs
KW - 1977
KW - Crying
KW - Individual Differences
KW - Mother Child Relations
KW - 1977
DO - 10.2307/1128478
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17572-032
AN - 2007-17572-032
AU - Barrett, David E.
T1 - Reflection-impulsivity as a predictor of children's academic achievement.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1977/12//
VL - 48
IS - 4
SP - 1443
EP - 1447
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
AD - Barrett, David E., Laboratory of Developmental Psychology, National Institute of Mental Health, Building 15K, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1 - Accession Number: 2007-17572-032. PMID: 608365 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Barrett, David E.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Academic Achievement; Elementary School Students; Impulsiveness; Reflectiveness. Classification: Academic Learning & Achievement (3550). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Comprehensive Tests of Basic Skills; Matching Familiar Figures Test DOI: 10.1037/t09907-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Dec, 1977.
AB - To examine the implications of differences in reflection-impulsivity for later academic achievement, 70 children were administered the Matching Familiar Figures test (MFF) in grade 4 and the Comprehensive Tests of Basic Skills (CTBS) in grades 4, 5, and 6. Children identified as reflective based on grade 4 MFF performance scored significantly higher on the CTBS achievement battery at all grade levels than those classified as impulsive. However, the 2 groups did not differ on the grade 5 or grade 6 achievement measures when scores were adjusted for initial differences in grade 4 CTBS. Similarly, while each of the continuous variables MFF error score and MFF response latency was significantly predictive of grade 5 and grade 6 achievement test scores, neither of the MFF variables significantly improved the prediction of academic performance when current level of achievement was statistically accounted for. Sex differences in the relations between the MFF variables and the achievement measures were identified; MFF error score was more strongly related to later academic achievement for boys than for girls, while MFF response latency was a better predictor of academic achievement for girls than for boys. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - academic achievement
KW - reflection
KW - impulsivity
KW - children
KW - 1977
KW - Academic Achievement
KW - Elementary School Students
KW - Impulsiveness
KW - Reflectiveness
KW - 1977
DO - 10.2307/1128505
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-032&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17572-061
AN - 2007-17572-061
AU - Anderson, Barbara J.
AU - Vietze, Peter
AU - Dokecki, Paul R.
T1 - Reciprocity in vocal interactions of mothers and infants.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1977/12//
VL - 48
IS - 4
SP - 1676
EP - 1681
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
AD - Anderson, Barbara J., National Institute of Child Health and Human Development, National Institutes of Health, Auburn Building, Room 220, Bethesda, MD, US, 20014
N1 - Accession Number: 2007-17572-061. PMID: 608379 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Anderson, Barbara J.; Social and Behavioral Science Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Biennial Meeting of the Society for Research in Child Development, Apr, 1975, Denver, CO, US. Grant Information: Vietze, Peter. Conference Note: Portions of this paper were presented at the aforementioned conference. Major Descriptor: Mother Child Relations; Reciprocity; Vocalization. Minor Descriptor: Mothers. Classification: Childrearing & Child Care (2956); Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 1977.
AB - Social responses of 24 mothers and 3-month-old infants were continuously observed and coded in the home to examine reciprocal influences in early vocal interactions. One of 4 dyadic vocal states (simultaneous vocalization, mother vocalizing alone, infant vocalizing alone, mutual silence) was assigned to each consecutive 1-sec interval of the 90-min observational records. The sequence of dyadic vocal states was represented by a first-order transition probability matrix. Transitions between states involving maternal and infant vocal onsets and offsets were analyzed. Results indicated that vocal onsets for both mother and infant were more likely when the other dyad member was vocalizing. There was no evidence of reciprocal influences for vocal offsets. It is suggested that differentiating response onset and offset is necessary for understanding vocal reciprocity in mother-infant interaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - reciprocity
KW - vocal interactions
KW - mother infant interaction
KW - 1977
KW - Mother Child Relations
KW - Reciprocity
KW - Vocalization
KW - Mothers
KW - 1977
U1 - Sponsor: National Institute of Education. Grant: NE-C-00-3-0260. Other Details: Research Contract. Recipients: Vietze, Peter
DO - 10.2307/1128534
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17572-061&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - TAN, HENRY K.
AU - ANDERSEN, JUDITH C.
T1 - Human Factor VIII: Morphometric Analysis of Purified Material in Solution.
JO - Science
JF - Science
Y1 - 1977/12/02/
VL - 198
IS - 4320
M3 - Article
SP - 932
EP - 934
SN - 00368075
AB - Study of purified human factor VIII in buffer by freeze-etch electron microscopy reveals rounded, rod-shaped particles measuring 22 by 42 nanometers. When thrombin was added to purified normal factor VIII, there was a rapid loss of rod-shaped particles during the first 15 minutes of incubation at 37°C. Purified plasma from two patients with severe hemophilia contained spherical particles measuring 10 to 50 nanometers in diameter, with no evidence of significant numbers of rod-shapedforms. Negatively stained and unstained air-dried samples of factor VIII corroborate the relative shape and size differences between normal and hemophiliac material. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436516; TAN, HENRY K. 1; ANDERSEN, JUDITH C. 1; Affiliations: 1: Hematology Section, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/2/1977, Vol. 198 Issue 4320, p932; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - COLE, ROGER M.
AU - MITCHELL, WILLIAM O.
AU - GARON, CLAUDE F.
T1 - Spiroplasmavirus citri 3: Propagation, Purification, Proteins, and Nucleic Acid.
JO - Science
JF - Science
Y1 - 1977/12/23/
VL - 198
IS - 4323
M3 - Article
SP - 1262
EP - 1263
SN - 00368075
AB - SVC3 is a short-tailed polyhedral virus particle morphologically detectable in many spiroplasmas. It was isolated from two different spiroplasmas (Spiroplasma citri and the suckling mouse cataract agent) by infecting lawns and broth culture of another strain of Spiroplasmavirus citri. Virions from either donor strain had a buoyant density of 1.26 grams per cubic centimeter (metrizamide) or 1.45 grams per cubic centimeter (cesium chloride), and contained five proteins and linear double-stranded DNA with a molecular weight of 14 × 106. Other spiroplasmaviruses have not been propagated, and the molecular weights of doublestranded DNA from other mycoplasma (Acholeplasma) viruses are unknown. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519203; COLE, ROGER M. 1; MITCHELL, WILLIAM O. 1; GARON, CLAUDE F. 1; Affiliations: 1: Laboratory of Streptococcal Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 12/23/1977, Vol. 198 Issue 4323, p1262; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GULATI, JAGDISH
AU - PALMER, L. G.
T1 - Potassium Accumulation in Frog Muscle: The Association-Induction Hypothesis versus the Membrane Theory.
JO - Science
JF - Science
Y1 - 1977/12/23/
VL - 198
IS - 4323
M3 - Article
SP - 1283
EP - 1284
SN - 00368075
N1 - Accession Number: 87519211; GULATI, JAGDISH 1; PALMER, L. G. 2; Affiliations: 1: Library of Physical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Department of Physiology, University of Pennsylvania, Philadelphia 19174; Issue Info: 12/23/1977, Vol. 198 Issue 4323, p1283; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-08720-000
AN - 9999-08720-000
AU - Pearlin, Leonard I.
AU - Schooler, Carmi
T1 - Coping Interview Schedule
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1978///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-08720-000. Partial author list: First Author & Affiliation: Pearlin, Leonard I.; National Institute of Mental Health. Release Date: 20120312. Correction Date: 20151109. Instrument Type: Interview Schedule/Guide. Test Format: The measures are based on adjective check-lists. There were four intensity categories from which subjects chose their response to each adjective.. Language: English. Constructs: Coping Strategies; Life Strains; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380).
AB - Purpose: This interview measures coping strategies in the general population in four areas: marriage, parenting, household economics, and work.
AB - Description: The Coping Interview Schedule (Pearlin & Schooler, 1978) was part of a larger investigation into the social origins of personal stress; a sample of 2300 18-65 year old people representative of the population in the Census-defined urbanized area of Chicago were interviewed. The schedule was designed to yield several distinct types of information. First, it asks people about potential life strains—that is, conflicts, frustrations, and threats—that earlier exploratory interviews had revealed to be commonly experienced in major social role areas. Second, the interview includes a number of questions about the coping repertoires people employ in dealing with the strains they experience in these roles. And third, it inquires into the emotional stresses that people feel and the extent to which they experience symptoms of depression and anxiety. The strains that are included foe study here were identified from themes that surfaced repeatedly during relatively unstructured interviews with over 100 subjects. Standardized questions about these strains were gradually developed, tested, and included in the final interview schedule. Eleven factors were delineated, three in marriage, three in the parental area, one in household economics, and four in occupation. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Coping Interview Schedule
KW - Interviews
KW - Life Strains
KW - Emotional Stress
KW - General Population Surveys
KW - Marriage
KW - Parenting
KW - Household Economics
KW - Coping Efficacy
KW - Coping Mechanisms
KW - Job Stress
U5 - Coping Interview Schedule [Test Development]The structure of coping. (AN: 1979-06036-001 from PsycINFO) Pearlin, Leonard I.; Schooler, Carmi; Mar, 1978. Source: Journal of Health and Social Behavior. 19(1), American Sociological Assn, US; Mar, 1978; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Location: United States; Sample: People Representative of the Population in the Census-Defined Urbanized Area of Chicago Keywords: Coping Interview Schedule; Interviews; Life Strains; Emotional Stress; General Population Surveys; Marriage; Parenting; Household Economics; Coping Efficacy; Coping Mechanisms; Job Stress; Subjects: Coping Behavior; Factor Structure; Financial Strain; Interviews; Marital Conflict; Occupational Stress; Parenting; Stress; Surveys;
DO - 10.1037/t08720-000
L3 - Partial; Full text; 999908720_partial_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-09180-000
AN - 9999-09180-000
AU - Edelbrock, Craig
AU - Sugawara, Alan I.
T1 - Sex Role Learning Index
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1978///
AD - Edelbrock, Craig, National Institute of Mental Health, Laboratory of Developmental Psychology, Building 15K, Bethesda, Maryland, United States, 20014
AV - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1 - Accession Number: 9999-09180-000. Acronyms: SERLI. Partial author list: First Author & Affiliation: Edelbrock, Craig; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20120312. Correction Date: 20160613. Instrument Type: Index/Indicator. Test Format: Participants sort the drawings according to whether they are appropriate for boys or girls.. Language: English. Constructs: Sex Role Stereotypes; Sex Roles; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Sex Role Learning Index is to compare children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate.
AB - Description: The Sex Role Learning Index (SERLI; Edelbrock & Sugawara, 1978) is a picture-choice instrument designed to compare preschool children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate. The goals in the development of the SERLI were to (a) compare children's preferences to both sex role stereotypes and each child's conception of what is sex appropriate, (b) distinguish between child and adult figures participating in the activities and roles depicted in the test items, and (c) use a probabilistic scoring system based on the order of the child's choices. The SERLI was designed to measure three concepts: (1) Sex role discrimination (SRD), (2) Sex role preference (SRP), and (3) Sex role confirmation (SRC). Separate SERLI forms were developed for boys and girls. Each form contains 30 black-and-white line drawings, organized into three sections: (a) the child figures section, (b) the adult figures section, and (c) the objects section. The items in the two forms are identical, except that the boys' form depicts only male figures engaged in the various activities and roles, while the girls' form depicts female figures. The child and adult figures sections contain 10 items each, half stereotyped as masculine and half as feminine. The Objects section contains 20 drawings of objects representing the activities and roles in the child and adult figures sections. The SERLI was designed to allow the individual child the opportunity to specify any particular item as being appropriate for both sexes and to score children's preferences according to both the child's point of view and cultural sex role stereotypes. The SERLI uses a simple Q-sort technique to gain a free- and forced-choice classification of the objects into sex role categories. The free-choice classification is used to score SRC, and the forced-choice classification is used to measure SRD. As part of the test development process, several studies were undertaken to assess the adequacy of the SERLI as an alternative conceptual and methodological approach to assessing sex role acquisition in preschool-aged children, overcoming some of the conceptual and methodological problems of previous instruments. Reliability estimates were also determined. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Child Attitudes
KW - Sex Role Acquisition
KW - Sex Role Confirmation Scale
KW - Sex Role Discrimination Scale
KW - Sex Role Learning Index
KW - Sex Role Preference Scale
KW - Sex Role Stereotypes
KW - Test Construction
KW - Young Children
KW - Psychometric Properties
KW - Sex Role Preferences
U5 - Sex Role Learning Index (SERLI) [Test Development]Acquisition of sex-typed preferences in preschool-aged children. (AN: 1979-28363-001 from PsycINFO) Edelbrock, Craig S.; Sugawara, Alan I.; Nov, 1978. Source: Developmental Psychology. 14(6), American Psychological Association, US; Nov, 1978; Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Sample: Children Aged 35-65 Months from Preschools and Daycare Centers Keywords: Child Attitudes; Sex Role Acquisition; Sex Role Confirmation Scale; Sex Role Discrimination Scale; Sex Role Learning Index; Sex Role Preference Scale; Sex Role Stereotypes; Test Construction; Young Children; Psychometric Properties; Subjects: Attitude Measures; Child Attitudes; Cognitive Discrimination; Early Childhood Development; Preference Measures; Preferences; Q-Sort; Sex Role Attitudes; Sex Roles; Stereotyped Attitudes; Test Construction; Test Reliability; Test Validity;
U5 - Sex Role Learning Index (SERLI) [Test Use]Sex-role preference in Australian aboriginal and White children. (AN: 1983-03186-001 from PsycINFO) Callan, Victor J.; Liddy, Linda; Jun, 1982. Source: The Journal of Social Psychology. 117(1), Heldref Publications, US; Jun, 1982; Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Ethnicity: Aboriginal and White Students; Location: Australia; Sample: Preschool and Kindergarten Students Aged 3-5 Keywords: Child Attitudes; Sex Role Learning Index; Sex Role Preferences; Sex Role Stereotypes; Young Children; Subjects: Attitude Measures; Child Attitudes; Early Childhood Development; Preference Measures; Preferences; Sex Role Attitudes; Sex Roles; Stereotyped Attitudes;
DO - 10.1037/t09180-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-09180-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-10996-000
AN - 9999-10996-000
AU - Aaronson, May
AU - Phillips, Julie
AU - Bertolucci, Darryl
AU - Aaronson, Doris
T1 - Preschool Preposition Test
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1978///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-10996-000. Acronyms: PPT. Partial author list: First Author & Affiliation: Aaronson, May; Department of Health, Education, & Welfare, National Institute of Mental Health, Rockville, Maryland, United States. Release Date: 20120507. Correction Date: 20151109. Instrument Type: Test. Test Format: To administer the test, the examiner hands the child a red half-ball that is covered with a magnetic material. on the flat side. The examiner directs the child to make placements with the ball onto an illustrated metal board- placed upright in. front of him. The board· is painted with a picture of a red boy facing a green car on a yellow background. The examiner reads aloud the 23 items in turn, each containing a preposition or prepositional phrase. In response, the child places the magnetized ball onto the board, where it adheres. The examiner then marks the child's placement with an X on a Picture Score Sheet.. Language: English. Constructs: Verbal Comprehension; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160).
N2 - Administration Method: Paper
AB - Purpose: The PPT is a receptive language test which examines the comprehension of verbal directions using spatial prepositions or prepositional phrases together·with objects.
AB - Description: This historic document is included through collaboration with the University of Akron, Archives of the History of American Psychology, University Libraries. The Preschool Preposition Test (PPT) is a developmental screening test for Head Start. It was used to identify children needing early scholastic assistance. The PPT is a quick, game-like, receptive language test for children ages 3 to 5, with validity and reliability data involving over 1400 children. Its long range predictive power is supported by impressive correlations between Head Start PPT scores and scores of mental ability and scholastic achievement five years later. Data point to a linkage between PPT scores and maternal nurturant and verbal behavior with the child. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Head Start Screening
KW - Preschool Preposition Test
KW - Receptive Language
KW - Verbal Comprehension
U5 - Preschool Preposition Test (PPT) [Test Primary Data] Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs); Population: Human; Male; Female; Sample: Preschoolers Keywords: Head Start Screening; Preschool Preposition Test; Receptive Language; Verbal Comprehension; Subjects: Project Head Start; Screening Tests; Verbal Comprehension;
DO - 10.1037/t10996-000
L3 - Full; Full text; 999910996_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-13885-000
AN - 9999-13885-000
AU - Pearlin, Leonard I.
AU - Schooler, Carmi
T1 - Pearlin's Self-Denigration Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1978///
AV - Commercial: No; Permissions: Contact Publisher; Fee: No. Test Items: No
N1 - Accession Number: 9999-13885-000. Partial author list: First Author & Affiliation: Pearlin, Leonard I.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: Respondents are asked how strongly they agree or disagree with measure items.. Language: English. Constructs: Self Denigration; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the scale is to assess the extent to which one holds negative attitudes toward oneself.
AB - Description: Pearlin's Self-Denigration Scale (Pearlin & Schooler, 1978) is a 4-item measure that assesses the extent to which one holds negative attitudes toward oneself. Participants are asked 'How strongly do you agree or disagree that: (1) I certainly feel useless at times; (2) At times I think I am no good at all; (3) I wish I could have more respect for myself ; (4) All in all, I am inclined to feel that I'm a failure.' It was developed as part of a study exploring the effectiveness of coping strategies in various settings. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Pearlin's Self-Denigration Scale
KW - Test Development
U5 - Pearlin's Self-Denigration Scale [Test Development]The structure of coping. (AN: 1979-06036-001 from PsycINFO) Pearlin, Leonard I.; Schooler, Carmi; Mar, 1978. Source: Journal of Health and Social Behavior. 19(1), American Sociological Assn, US; Mar, 1978; Administration: Paper Population: Human; Male; Female; Sample: Various Individuals Keywords: Pearlin's Self-Denigration Scale; Test Development; Subjects: Rating Scales; Self-Defeating Behavior; Test Construction;
DO - 10.1037/t13885-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13885-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - GEN
AU - Schneider, John H
T1 - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
JO - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
JF - Cancergrams: a large-scale system for selective dissemination of information to cancer researchers
Y1 - 1978///
M3 - Book
AB - One of the services of the international cancer research data bank (icrdb) program is a large-scale system for the selective dissemination of information to groups fo cancer researchers. This system is based on the production of 60 different current awareness bulletins, each covering a major cancer research topic. These bulletins, called cancergrams, are mailed each month to researchers working in the area covered by the corresponding cancergram
N1 - Accession Number: ISTA1500389; Schneider, John H 1; Affiliations: 1 : Office Of International Affairs, National Cancer Institute, Bethesda, Md; Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Parrillo, J. E.
AU - Fauci, A. S.
T1 - Mechanisms of corticosteroid action on lymphocyte subpopulations.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/01//
VL - 31
IS - 1
M3 - Article
SP - 116
EP - 125
PB - Wiley-Blackwell
SN - 00099104
AB - The present study investigated the effect of dexamethasone (DEX) administration on different populations of mononuclear cells and neutrophils mediating antibody-dependent cellular cytotoxicity (ADCC) against different target cells. Mononuclear cells (lymphocytes and monocytes) and neutrophils were obtained from twenty-seven normal volunteers at 0, 4, 24 and 48 hr after oral administration of 21 mg of DEX. ADCC was determined utilizing the following targets: human red blood cells (HRBC), Chang liver cells (Ch) and human heart cells (HHC). The predominant mononuclear effector in HRBC killing was shown to be a monocyte and in Ch and HHC killing, a K cell. As previously shown, DEX produced a profound monocytopenia and lymphocytopenia at 4 hr with a return of lymphocyte counts to normal and monocyte counts to supra-normal at 24 hr. At the point of maximal mono-cytopenia, monocyte-mediated HRBC killing decreased from a geometric mean of 14 to 4 lytic units per 108 effector cells (P<0-05) and rebounded at 24 hr to a mean of 39 lytic units (P<0.02) with the rebound monocytosis. At the point of absolute lymphopenia (4 hr), there was a relative enrichment in the proportion of lymphocytes bearing an Fc receptor (K cells, P<0.01). Concomitant with this was an increase in ADCC against Ch and HHC from geometric means of 1121 to 7172 lytic units and 939 to 7354 lytic units (P<0.001) respectively. Thus, a major action of DEX administration on mononuclear ADCC was to differentially enrich or deplete different effector cells to and from the circulation, causing changes in cytotoxicity. Since the cytotoxicity paralleled the proportion of effector cells, the cells remaining in the circulation following DEX administration retained normal antibody-dependent cytotoxic capabilities. Neutrophil-mediated ADCC against HRBC significantly increased at 4 hr from a geometric mean of 3785 to 20142 lytic units (P<0.02) concomitant with the blood neutrophilia and remained elevated for 72 hr. Neutrophil ADCC against Ch and HHC was minimal and was not affected by DEX administration. This study demonstrates differential effects of corticosteroids on antibody-dependent cell-mediated cytotoxicity, reflecting changes in proportion of circulating effector cell populations. These changes depend on (a) the target cell employed, (b) the effector cell mediating cytotoxicity and (c) the duration of time since the last dose of corticosteroid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - CELL proliferation
KW - CELL receptors
KW - ADRENOCORTICAL hormones
KW - CELL death
KW - LIVER cells
N1 - Accession Number: 16253620; Parrillo, J. E. 1,2,3 Fauci, A. S. 1,2,3; Affiliation: 1: Laboratory of Clinical Investigation, Bethesda, Maryland, U.S.A.. 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.. 3: National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jan1978, Vol. 31 Issue 1, p116; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Subject Term: CELL receptors; Subject Term: ADRENOCORTICAL hormones; Subject Term: CELL death; Subject Term: LIVER cells; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Giambra, Leonard M.
AU - Traynor, Thomas D.
T1 - DEPRESSION AND DAYDREAMING: AN ANALYSIS BASED ON SELF-RATINGS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1978/01//
VL - 34
IS - 1
M3 - Article
SP - 14
EP - 25
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article presents information on depression and daydreaming. Daydreaming and related mental activity were determined from responses to a retrospective questionnaire developed by previous studies. Each Irnaginal Processes Inventory (IPI) item consists of five options that represent points on a continuum that implies frequency or quantity. A total of 28 scales are determined from nonover- lapping items depression, anxiety, poor interpersonal relationships, and alcoholism. Thus it appears that daydreaming is related to affect and that the affect associated with depression may be a potent determinant of the daydreaming. This study was a further investigation of the relationship between daydreaming and depression.
KW - MENTAL depression
KW - STRESS (Psychology)
KW - MENTAL health
KW - SELF-evaluation
KW - DREAMS
KW - ALCOHOLICS
KW - INTERPERSONAL relations
N1 - Accession Number: 15828575; Giambra, Leonard M. 1 Traynor, Thomas D. 2; Affiliation: 1: National Institute on Aging. 2: Miami University.; Source Info: Jan1978, Vol. 34 Issue 1, p14; Subject Term: MENTAL depression; Subject Term: STRESS (Psychology); Subject Term: MENTAL health; Subject Term: SELF-evaluation; Subject Term: DREAMS; Subject Term: ALCOHOLICS; Subject Term: INTERPERSONAL relations; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kapur, Malavika
T1 - A SHORT SCREENING BATTERY OF TESTS TO DETECT ORGANIC BRAIN DYSFUNCTION.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1978/01//
VL - 34
IS - 1
M3 - Article
SP - 104
EP - 111
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article presents information on a short screening device to measure organic brain dysfunction suitable for literate and non-literate populations. It was the aim of this study to construct a screening battery of psychological tests to detect in a short time and without sophisticated equipment the presence of organic brain dysfunction among literate and nonliterate Ss. More specifically, the aims of the study were to examine whether certain selected psychological tests could discriminate between a matched group of those who suffer organic brain dysfunction and normals, to examine whether these tests could be combined through a statistical procedure in the form of a battery that would have higher predictive ability and lower misclassification rate than the individual tests.
KW - PSYCHOLOGICAL tests
KW - PSYCHOLOGY
KW - DIAGNOSIS
KW - CLINICAL psychology
KW - HUMAN biology
KW - MEDICAL equipment
N1 - Accession Number: 15828597; Kapur, Malavika 1; Affiliation: 1: National Institute of Mental Health and Neuro Sciences, Bangalore, India.; Source Info: Jan1978, Vol. 34 Issue 1, p104; Subject Term: PSYCHOLOGICAL tests; Subject Term: PSYCHOLOGY; Subject Term: DIAGNOSIS; Subject Term: CLINICAL psychology; Subject Term: HUMAN biology; Subject Term: MEDICAL equipment; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Edelson, Richard
AU - Finkelman, Fred
AU - Steinberg, Alfred
AU - Ahmed, Aftab
AU - Broder, Samuel
AU - Strong, Michael
AU - Green, Ira
T1 - REACTIVITY OF LUPUS ERYTHEMATOSUS ANTIBODIES WITH LEUKEMIC HELPER T CELLS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/01//
VL - 70
IS - 1
M3 - Article
SP - 42
EP - 44
SN - 0022202X
AB - Immunoabsorbent columns, containing membrane fragments of either leukemic "helper" T cells or B cell lymphoblasts, were used to isolate and study antilymphocyte antibodies from plasmas of 2 patients with systemic lupus erythematosus (SLE). Both plasmas contained IgG which bound to and could be eluted from the "helper" T cell column. These antibodies significantly inhibited normal lymphocyte proliferative responses to microbial and histocompatibility antigens. The findings indicate that these SLE plasmas contain immunoglobulins of the IgG class which react with leukemic "helper" T cells and inhibit normal effector T cell function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUPUS erythematosus
KW - SKIN diseases
KW - IMMUNOGLOBULINS
KW - LEUKEMIC reticuloendotheliosis
KW - T cells
KW - B cells
N1 - Accession Number: 12543469; Edelson, Richard 1,2,3,4,5 Finkelman, Fred 1,2,3,4,5 Steinberg, Alfred 1,2,3,4,5 Ahmed, Aftab 1,2,3,4,5 Broder, Samuel Strong, Michael 1,2,3,4,5 Green, Ira 1,2,3,4,5; Affiliation: 1: The Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, New York 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. 3: National Institute of Arthritis, Metabloic and Digestive Diseases, National Cancer, Bethesda, Maryland, U.S.A. 4: Institute, N.I.H., Bethesda, Maryland, U.S.A. 5: Naval Medical Research Institute, Bethesda, Maryland, U.S.A.; Source Info: Jan1978, Vol. 70 Issue 1, p42; Subject Term: LUPUS erythematosus; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: LEUKEMIC reticuloendotheliosis; Subject Term: T cells; Subject Term: B cells; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543469
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42051-004
AN - 2013-42051-004
AU - Hersh, S. P.
T1 - Sweden's approach to health screening for preschool children.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1978/01//
VL - 48
IS - 1
SP - 33
EP - 39
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Hersh, S. P., National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD, US, 20852
N1 - Accession Number: 2013-42051-004. PMID: 623220 Partial author list: First Author & Affiliation: Hersh, S. P.; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Health Care Services; Health Screening; Program Development. Minor Descriptor: Preschool Students. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Sweden. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1978.
AB - The findings of a recent study of the approach taken by Sweden to a perceived problem in that nation’s child health care system are reviewed. The Swedish experience is discussed in terms of its application to the United States, with particular reference to EPSDT and the newly proposed Child Health Assessment Program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health screening
KW - preschool children
KW - child health care system
KW - health assessment programs
KW - 1978
KW - Child Care
KW - Health Care Services
KW - Health Screening
KW - Program Development
KW - Preschool Students
KW - 1978
DO - 10.1111/j.1939-0025.1978.tb01287.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42051-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09710-001
AN - 2005-09710-001
AU - Buchsbaum, Monte S.
AU - Haier, Richard J.
T1 - Biological Homogeneity, Symptom Heterogeneity, and the Diagnosis of Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1978///
VL - 4
IS - 4
SP - 473
EP - 475
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Buchsbaum, Monte S., NIMH, Bldg. 10, Rm. 2N212, 9000 Rockville Pike, Bethesda, MD, US, 20014
N1 - Accession Number: 2005-09710-001. PMID: 734358 Partial author list: First Author & Affiliation: Buchsbaum, Monte S.; Laboratory of Psychology and Psychopathology, Division of Clinical and Behavioral Research, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Biopsychosocial Approach; Psychiatric Symptoms; Psychodiagnosis; Schizophrenia. Minor Descriptor: Affective Disorders; Positive and Negative Symptoms. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1978.
AB - Recent research progress warrants the use of biological variables for developing psychiatric diagnostic systems just as biological measures are used in other branches of medicine. In fact, psychiatrists already bow to internal medicine when biological indicators of tertiary syphilis, lupus, or hypothyroidism are present. Even in areas not yet ceded to infectious disease, immunology or endocrinology, biological factors are used to make diagnoses. Though unsanctioned, the use of lithium carbonate response in differentially diagnosing affective disorder and schizophrenia is not uncommon. In this case, the clinical psychiatrist may be conceptually step ahead of the biological researcher, because he has identified a diagnostic group homogeneous with respect to a salient biological feature and is willing to ignore the symptom heterogeneity. While he might write 'affective disorder' in the chart, the implied diagnosis is really 'lithium sensitive behavioral syndrome.' As classification is the first step in science, diagnosis is the most fundamental problem in psychiatry. Biological researchers have an opportunity to develop new modes of psychiatric diagnoses that go beyond the traditional categories and draw upon new knowledge from the neurosciences. Today's biological researcher searching for a laboratory test for 'schizophrenia' is not going to find it. Multiple etiologies, false negative symptom elicitation, false positive symptom expression, and the lack of external validating criteria all prevent the identification of a homogeneous schizophrenic group for study. A laboratory test for 'dopamine disease,' however, is a possibility with current technology. Whether dopamine disease or other biologically based diagnoses are clinically useful diagnoses needs to be determined with new research strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - symptom heterogeneity
KW - affective disorders
KW - biological homogeneity
KW - psychiatric diagnostic systems
KW - symptom expression
KW - 1978
KW - Biopsychosocial Approach
KW - Psychiatric Symptoms
KW - Psychodiagnosis
KW - Schizophrenia
KW - Affective Disorders
KW - Positive and Negative Symptoms
KW - 1978
DO - 10.1093/schbul/4.4.473
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09710-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Rechler, Mathew M.
AU - Frylund, Linda
AU - Nissley, S. Peter
AU - Hall, Kerstin
AU - Podskalny, Judith M.
AU - Skottner, Anna
AU - Moses, Alan C.
T1 - Purified Human Somatomedin A and Rat Multiplication Stimulating Activity.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/01/02/
VL - 82
IS - 1
M3 - Article
SP - 5
EP - 12
PB - Wiley-Blackwell
SN - 00142956
AB - We have compared the mitogenic activity and reactivity in receptor binding assays of somatomedin A and multiplication-stimulating activity (MSA), two acid-soluble polypeptides of molecular weight 7-10 000 that possess weak intrinsic insulin-like metabolic activity. Somatomedin A was purified to homogeneity from human plasma, and MSA was purified to homogeneity from the conditioned culture media of a cell line, BRL 3A, derived from rat liver. The two peptides stimulated DNA synthesis in chick embryo fibroblasts 3-4-fold and have superimposable doseresponse curves. Addition of either peptide to chick embryo fibroblasts plated in serum-free medium increased the cell number by 150% in 4 days, compared with an increase of 25% in control cultures receiving no additions. The two peptides also stimulated DNA synthesis in human fibroblasts in culture 3-4-fold. Specific receptors for MSA and/or somatomedin A could be demonstrated in intact cells or membranes from chick embryo fibroblasts, human fibroblasts, human placenta, rat liver, and the BRL 3A2 cell line, a subclone of the line that produces MSA. Unlabeled MSA and somatomedin A inhibited the binding of 125I-labeled MSA and 125I-labeled somatomedin A to each of these receptors with comparable potency. In chick embryo fibroblasts, human fibroblasts, and human placental membranes, the binding of both radioactive ligands also was inhibited by insulin, consistent with the interpretation that 125I-labeled MSA and 125I-labeled somatomedin A were binding to the same receptor. By contrast, in the BRL 3A2 cell line, insulin inhibited the binding of 125I-labeled somatomedin A, but not the binding of 125I-labeled MSA, suggesting that the two labeled peptides were binding to different receptors in this cell line. Moreover, 125I-labeled MSA, but not 125I-labeled somatomedin A, bound specifically to rat liver plasma membranes. These results indicate that human somatomedin A and rat MSA are closely related, but not identical, peptides. They have similar mitogenic activity for cultured fibroblasts, and cross-react with specific cell receptors with comparable potency. The two radioactively labeled peptides, however, can be distinguished by certain cell surface receptors for somatomedin-like peptides. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOMATOMEDIN
KW - SOMATOTROPIN
KW - PEPTIDES
KW - GROWTH factors
KW - PROTEINS
KW - BIOCHEMISTRY
N1 - Accession Number: 13602365; Rechler, Mathew M. 1 Frylund, Linda 1 Nissley, S. Peter 1 Hall, Kerstin 1 Podskalny, Judith M. 1 Skottner, Anna 1 Moses, Alan C. 1; Affiliation: 1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Metabolism Branch, National Cancer Institute, National Institutes of Health Bethesda, Maryland; AB Kabi, Stockholm, and Department of Endocrinology, Karolinska Hospital Stockholm; Source Info: 1/2/78, Vol. 82 Issue 1, p5; Subject Term: SOMATOMEDIN; Subject Term: SOMATOTROPIN; Subject Term: PEPTIDES; Subject Term: GROWTH factors; Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pitha, Josef
T1 - Reagents Specific for Cell Surface Components.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/01/02/
VL - 82
IS - 1
M3 - Article
SP - 285
EP - 292
PB - Wiley-Blackwell
SN - 00142956
AB - Mercury, diazonium ions and dyes which bind nucleic acids were covalently linked to dextrans using methods that resulted in non-hydrolyzable reagent-dextran bonds without impairing the binding abilities of the reagents, i.e. these dextran derivatives reacted with thiols, phenols/ imidazoles and nucleic acids respectively. Since these dextran derivatives cannot penetrate into cells and since dextran itself does not bind to cells, these compounds represent reagents specific for the cell surface. They may be used both to evaluate cell surface constituents of intact cells and to affect viable cells via an interaction with those constituents. Mercury-dextran was found to bind to cells; the amount of mercury thus attached to the cells was about ten times smaller than when an equivalent concentration of free mercury ions was used. Mercury-dextran, bound to cells after a 30-min exposure at room temperature, was localized on the surface of these cells, as sodium borohydride reduced this complex giving rise to the intact cells, elementary mercury and free dextran which was released into medium. When cells were constantly exposed to the mercury-dextran, its toxic effects were comparable to that of free mercury ions. Diazonium-dextran, which also binds tightly to the cell surface, was also considerably toxic. Dextrans substituted with dyes which bind to nucleic acids were less toxic than the parent dyes themselves; it was shown that the attachment of such a dye to dextran decreased the binding of dye to cells under detection limits. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MERCURY
KW - NUCLEIC acids
KW - BIOMOLECULES
KW - DEXTRAN
KW - BLOOD plasma substitutes
KW - BIOCHEMISTRY
N1 - Accession Number: 13605667; Pitha, Josef 1; Affiliation: 1: National Institutes of Health, National Institute on Aging-Gerontology Research Center, Baltimore City Hospitals, Baltimore, Maryland; Source Info: 1/2/78, Vol. 82 Issue 1, p285; Subject Term: MERCURY; Subject Term: NUCLEIC acids; Subject Term: BIOMOLECULES; Subject Term: DEXTRAN; Subject Term: BLOOD plasma substitutes; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feldman, Stuart L.
AU - Squibb, Katherine S.
AU - Cousins, Robert J.
T1 - Degradation of cadmium‐thionein in rat liver and kidney.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 805
EP - 813
SN - 00984108
AB - [ 3 H]Cystine and 115mCd were incorporated into hepatic and renal Cd‐thionein in response to sc administration of 4.4 μmol of Cd 2+ containing 115mCd. Cd‐thioneinbound 115mCd reached a plateau by 24 and 72 h after the Cd 2+ injection in liver and kidney, respectively. The half‐life (t ½ ) of 3 H‐labeled hepatic Cd‐thionein was 3.5 d, whereas the average t½ of the soluble proteins was 3.7 d. The t½ of 3 H‐labeled renal Cd‐thionein was 3.7 d, whereas the average t½ of the soluble renal proteins was 3.8 d. In marked contrast, the 115m Cd content of both hepatic and renal Cd‐thionein was virtually unchanged, even 9 d after administration of this radionuclide. These data indicate that the protein moiety of metallothionein is degraded, although there appears to be a concomitant rebinding of Cd 2+ to nascent thionein polypeptide chains. Thus the lack of metallothionein degradation per se does not account for the long‐term retention of Cd 2+ in liver and kidney during chronic exposure. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196190; Feldman, Stuart L. 1,2 Squibb, Katherine S. 1,3 Cousins, Robert J. 1,4; Affiliation: 1: Department of Nutrition, Rutgers University, New Brunswick, New Jersey 2: Department of Chemistry, Florida State University, Tallahassee, Florida, 32306 3: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 4: Department of Nutrition, Cook College, Rutgers University, Thompson Hall, P.O. Box 231, New Brunswick, New Jersey, 08903; Source Info: Jan1978, Vol. 4 Issue 5/6, p805; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15287397809529701
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ong, Tong‐man
AU - Slade, Barbara
T1 - Mutagenicity and mutagenic specificity of metronidazole and niridazole in neurospora crassa.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 815
EP - 824
SN - 00984108
AB - Mutagenicity and mutagenic specificity of niridazole and metronidazole, two chemotherapeutic agents used in the treatment of human parasitic diseases, were studied with the ad‐3 test system of Neurospora crassa. The results show that neither compound is mutagenic in resting conidia. In growing vegetative cells, however, both compounds are mutagenic in N. crassa. Genetic analysis of the mutants indicated that niridazole induces predominantly base‐pair substitution mutations. None of the niridazole‐induced mutants resulted from multilocus deletions. The spectra of genetic alterations induced by metronidazole are similar to those induced by the mono‐functional alkylating agents ethyleneimine (El), ethylmethanesulfonate (EMS), and ICR‐177. It is therefore suggested that the mechanism of mutation induction by metronidazole in Neurospora is similar to that of monofunctional alkylating agents. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196191; Ong, Tong‐man 1,2 Slade, Barbara 1; Affiliation: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2: National Institute for Occupational Safety and Health, ALOSH, Morgantown, West Virginia, 26505; Source Info: Jan1978, Vol. 4 Issue 5/6, p815; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397809529702
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=76196191&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Callen, D. F.
AU - Larson, R. A.
T1 - Toxic and genetic effects of fuel oil photoproducts and three hydroperoxides in Saccharomyces cerevisiae.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 913
EP - 917
SN - 00984108
AB - Phototransformation of no. 2 fuel oil by UV irradiation at wavelengths designed to simulate sunlight resulted in the formation of products toxic to the yeast Saccharomyces cerevisiae. Increasing the time of irradiation of the fuel oil samples increased the toxicity. Fuel oil that had been irradiated for 12 or 24 h was convertagenic to the yeast strain D4. The toxicity and genetic activity of these samples could be removed by treatment with thiacyclohexane. It is thought that hydroperoxides are the primary photoproducts responsible for these biological effects. Of three hydroperoxides tested, tert ‐butyl was convertagenic and cumene and tetralin were not. However, all three hydroperoxides were toxic to yeast. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196200; Callen, D. F. 1,2 Larson, R. A. 1,3; Affiliation: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2: School of Biological Sciences, Flinders University of South Australia, Bedford Park, South Australia, 5042 3: Stroud Water Research Center, Academy of Natural Sciences of Philadelphia, Avondale, Pennsylvania; Source Info: Jan1978, Vol. 4 Issue 5/6, p913; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/15287397809529711
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kauffman, Stuart A.
AU - Shymko, Ronald M.
AU - Trabert, Kenneth
T1 - Control of Sequential Compartment Formation in Drosophila.
JO - Science
JF - Science
Y1 - 1978/01/20/
VL - 199
IS - 4326
M3 - Article
SP - 259
EP - 270
SN - 00368075
AB - During development of Drosophila melanogaster, sequential commitment to alternative development programs occurs in neighboring groups of cells. These commitments appear to be reflected by lines of clonal restriction, called compartmental boundaries, which progressively subdivide the early embryo, and later the imaginal discs, which give rise to different adult appendages. We propose that a reaction- diffusion system acts throughout development and generates a sequence of differently shaped chemical patterns. These patterns account for the sequence and geometries of compartmental boundaries, and predict that each terminal compartment is specified by a unique combination of binary choices made during its formation. This binary "code" interprets coherently the patterned metaplasia seem in transdetermination and homeotic mutations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460085; Kauffman, Stuart A. 1; Shymko, Ronald M. 2; Trabert, Kenneth 3,4; Affiliations: 1: Associate Professor, Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19174; 2: Postdoctoral Feliow, Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19174; 3: Research Assistant, Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 4: Environmental Protection Agency, Washington, D.C.; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p259; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KINOSHITA, NADAO
AU - GELBOIN, HARRY V.
T1 - β-Glucuronidase Catalyzed Hydrolysis of Benzo[a]pyrene-3-Glucuronide and Binding to DNA.
JO - Science
JF - Science
Y1 - 1978/01/20/
VL - 199
IS - 4326
M3 - Article
SP - 307
EP - 309
SN - 00368075
AB - β-Glucuronidase catalyzes the hydrolysis of benzo[a]pyrene-3-glucuronide to 3-hydroxybenzo[a]pyrene. During the enzymatic hydrolysis, a benzo[a]pyrene derivative is formed which binds to DNA to a far greater extent than either the 3-hydroxybenzo[a]pyrene or its glucuronide. These results suggest that conjugates of benzo[a]pyrene may be converted by β-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo[a]pyrene to activated intermediates that are possibly carcinogenic. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460089; KINOSHITA, NADAO 1; GELBOIN, HARRY V. 1; Affiliations: 1: Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p307; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLEIN, D. C.
AU - BUDA, M. J.
AU - KAPOOR, C. L.
AU - KRISHNA, G.
T1 - Pineal Serotonin N-Acetyltransferase Activity: Abrupt Decrease in Adenosine 3',5'-Monophosphate May Be Signal for "Turnoff".
JO - Science
JF - Science
Y1 - 1978/01/20/
VL - 199
IS - 4326
M3 - Article
SP - 309
EP - 311
SN - 00368075
AB - Dispersed pinealocytes have been used to study the role of adenosine 3',5'-monophosphate (cyclic AMP) in the "turnoff" of N-acetyltransferase activity. Activity was first stimulated 100-fold by treating cells with l-norepinephrine. I-Propranolol acted stereospecifically to rapidly reverse this, resulting in a 70 percent loss of enzyme activity within 15 minutes. An even more rapid l-propranolol-induced decrease in cyclic AMP also occurred. This together with the observation that the inhibitory effect of l-propranolol on N-acetyltransferase was blocked by dibutyryl cyclic AMP and phosphodiesterase inhibitors indicate that an abrupt decrease in cyclic AMP may be the signal for the rapid decrease in pineal N-acetyltransferase activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460090; KLEIN, D. C. 1; BUDA, M. J. 1; KAPOOR, C. L. 2; KRISHNA, G. 2; Affiliations: 1: Neuroendocrinology Unit, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014; 2: Section on Drug-Tissue Interaction, Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p309; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHMECHEL, DONALD
AU - MARANGOS, PAUL J.
AU - ZIS, ATHANASIOS P.
AU - BRIGHTMAN, MILTON
AU - GOODWIN, FREDERICK K.
T1 - Brain Enolases as Specific Markers of Neuronal and Glial Cells.
JO - Science
JF - Science
Y1 - 1978/01/20/
VL - 199
IS - 4326
M3 - Article
SP - 313
EP - 315
SN - 00368075
AB - There are three distinct enolase isoenzymes in brain: neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybridform. Light microscopy with immunocytochemical techniques has permitted localization of nonneuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460100; SCHMECHEL, DONALD 1; MARANGOS, PAUL J.; ZIS, ATHANASIOS P.; BRIGHTMAN, MILTON 2; GOODWIN, FREDERICK K.; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neuropathology and Neuroanatomical Science, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p313; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MARCHALONIS, JOHN J.
AU - BUCANA, CORA
AU - HOYER, LARRY
AU - WARR, GREGORY W.
AU - HANNA, JR., M. G.
AU - SZENBERG, ALEX
T1 - Visualization of a Guinea Pig T Lymphocyte Surface Component Cross-Reactive with Immunoglobulin.
JO - Science
JF - Science
Y1 - 1978/01/27/
VL - 199
IS - 4327
M3 - Article
SP - 433
EP - 435
SN - 00368075
AB - Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2 fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine κ chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460135; MARCHALONIS, JOHN J. 1; BUCANA, CORA 1; HOYER, LARRY 1; WARR, GREGORY W. 1; HANNA, JR., M. G. 1; SZENBERG, ALEX 2; Affiliations: 1: Cancer Biology Program, National Cancer Institute, Frederick Cancer Research Center, Frederick, Maryland 21701; 2: Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Issue Info: 1/27/1978, Vol. 199 Issue 4327, p433; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kingman, Albert
T1 - Adequate cohort sizes for caries clinical trials.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1978/02//
VL - 6
IS - 1
M3 - Article
SP - 30
EP - 35
SN - 03015661
AB - Methods of determining cohort sizes were examined to determine their appropriateness for use in multi-group caries clinical trials. The appropriate method to use depends on the type of trial being planned. It is shown that multiple comparison methods using certain Bonferonni type t-statistics ought to be used in trials in which different levels or frequencies of application of known caries inhibitors are being tested. It is also demonstrated that using tile F-test procedure in the determination of cohort sizes can result in unacceptable low sensitivity levels being realized for the comparisons of primary concern. Tables are presented which can be used to determine group sizes needed to achieve specified sensitivity levels for two-group trials and multi-group trials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries
KW - DENTAL pathology
KW - CLINICAL trials
KW - PREVENTIVE dentistry
KW - ORAL hygiene
KW - MEDICAL care -- Research
N1 - Accession Number: 12103524; Kingman, Albert 1; Affiliation: 1: Biometry Section, National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, U.S.A.; Source Info: Feb1978, Vol. 6 Issue 1, p30; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: CLINICAL trials; Subject Term: PREVENTIVE dentistry; Subject Term: ORAL hygiene; Subject Term: MEDICAL care -- Research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12103524
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katz, Stephen I.
AU - Strober, Warren
T1 - THE PATHOGENESIS OF DERMATITIS HERPETIFORMIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/02//
VL - 70
IS - 2
M3 - Article
SP - 63
EP - 75
SN - 0022202X
AB - Dermatitis herpetiformis is an intensely itchy papulovesicular eruption which is usually symmetrically distributed on extensor surfaces. The major areas of predilection are the elbows, knees, buttocks, scalp, posterior nuchal area, sacrum and shoulders; in addition, the face and facial hairline are occasionally affected and may be the only areas with lesions in patients who are otherwise adequately treated. The disease may start at any age, the late second and third decades being most common, and then persists indefinitely although it may vary in severity: There are a few patients in whom the immunologically verified disease remits for periods of months and even a few years in the absence of treatment.
KW - SKIN -- Inflammation
KW - ITCHING
KW - IMMUNOLOGY
KW - SKIN diseases
KW - SKIN
KW - FACE
N1 - Accession Number: 12541202; Katz, Stephen I. 1 Strober, Warren 1; Affiliation: 1: Dermatology and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb78, Vol. 70 Issue 2, p63; Subject Term: SKIN -- Inflammation; Subject Term: ITCHING; Subject Term: IMMUNOLOGY; Subject Term: SKIN diseases; Subject Term: SKIN; Subject Term: FACE; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1523-1747.ep12541202
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RAPOPORT, JUDITH L.
AU - BUCHSBAUM, MONTE S.
AU - ZAHN, THEODORE P.
AU - WEINGARTNER, HERBERT
AU - LUDLOW, CHRISTY
AU - MIKKELSEN, EDWIN J.
T1 - Dextroamphetamine: Cognitive and Behavioral Effects in Normal Prepubertal Boys.
JO - Science
JF - Science
Y1 - 1978/02/03/
VL - 199
IS - 4328
M3 - Article
SP - 560
EP - 563
SN - 00368075
AB - The behavioral, cognitive, and electrophysiological effect of a single dose of dextroamphetamine (0.5 milligram per kilogram of body weight) or placebo was examined in 14 normal prepubertal boys (mean age, 10 years 11 months) in a double-blind study. When amphetamine was given, the group showed a marked decrease in motor activity and reaction time and improved performance on cognitive tests. The similarity of the response observed in normal children to that reported in children with "hyperactivity" or minimal brain dysfunction casts doubt on pathophysiological models of minimal brain dysfunction which assume that children with this syndrome have a clinically specific or "paradoxical" response to stimulants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460194; RAPOPORT, JUDITH L. 1; BUCHSBAUM, MONTE S. 1; ZAHN, THEODORE P. 2; WEINGARTNER, HERBERT 2; LUDLOW, CHRISTY 3; MIKKELSEN, EDWIN J. 4; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Psychology and Psychopathology, National Institute of Mental Health; 3: Communicative Disorders Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 4: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p560; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MARY F. WALDROP
AU - BELL, RICHARD Q.
AU - MCLAUGHLIN, BRIAN
AU - HALVERSON JR, CHARLES F.
T1 - Newborn Minor Physical Anomalies Predict Short Attention Span, Peer Aggression, and Impulsivity at Age 3.
JO - Science
JF - Science
Y1 - 1978/02/03/
VL - 199
IS - 4328
M3 - Article
SP - 563
EP - 565
SN - 00368075
AB - From a 5-to 10-minute newborn examination, behaviors of males at age 3 could be predicted. The number of minor physical anomalies, assessed soon after birth, was significantly related to a cluster of behaviors that are frequently labeled hyperactivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460201; MARY F. WALDROP 1; BELL, RICHARD Q. 2; MCLAUGHLIN, BRIAN 3; HALVERSON JR, CHARLES F. 4; Affiliations: 1: Laboratory of Developmental Psychology, National Institute of Health, Bethesda, Maryland 2001; 2: Department of Psychology, University of Virginia, Charlottesville 22904; 3: Laboratory of Developmental Psychology, National Institute of Mental Health; 4: College of Home Economics, University of Georgia, Athens 306; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p563; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MALOFF, BRUCE L.
AU - SCORDILIS, S. P.
AU - TEDESCHI, HENRY
T1 - Membrane Potentials of Mitochondria.
JO - Science
JF - Science
Y1 - 1978/02/03/
VL - 199
IS - 4328
M3 - Article
SP - 568
EP - 569
SN - 00368075
N1 - Accession Number: 87460184; MALOFF, BRUCE L. 1; SCORDILIS, S. P. 2; TEDESCHI, HENRY 3; Affiliations: 1: State University of New York, Upstate Medical Center, Syracuse 13210; 2: Section of Molecular Cardiology, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Biological Sciences and Neurobiology Center, State University of New York, Albany 12222; Issue Info: 2/3/1978, Vol. 199 Issue 4328, p568; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOREEDA, MASATO
AU - MOORE, PATRICK D.
AU - WISLOCKI, PETER G.
AU - LEVIN, WAYNE
AU - CONNEY, ALLAN H.
AU - YAGI, HARUHIKO
AU - JERINA, DONALD M.
T1 - Binding of Benzo[a]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity.
JO - Science
JF - Science
Y1 - 1978/02/17/
VL - 199
IS - 4330
M3 - Article
SP - 778
EP - 781
SN - 00368075
AB - The formation, stereostructure, and cellular reactions of the 7,8-diol- 9,10-epoxide metabolites of the carcinogen benzo[a]pyrene have been examined after topical application of benzo[a]pyrene to the skin of mice. In this known target tissue, polymer adducts from diastereomeric diol epoxides, (+)-(7S, 8R, 9R, ]OR) and (+)-(7R, 8S, 9R, ]OR), were formed stereospecifically from their corresponding 7,8-dihydrodiols. Both diol epoxides bind with proteins, RNA, and DNA in vivo. For the nucleic acids, binding occurs preferentially at the 2-amino group of guanine in cellular RNA and DNA in vivo. Methods for establishing the structure of the cellular adducts as well as the possible biological implications of their formation are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460785; KOREEDA, MASATO 1; MOORE, PATRICK D. 1; WISLOCKI, PETER G. 2; LEVIN, WAYNE 2; CONNEY, ALLAN H. 2; YAGI, HARUHIKO 3; JERINA, DONALD M. 3; Affiliations: 1: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218; 2: Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110; 3: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/17/1978, Vol. 199 Issue 4330, p778; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROSEN, LEON
AU - TESH, ROBERT B.
AU - JIH CHING LIEN
AU - CROSS, JOHN H.
T1 - Transovarial Transmission of Japanese Encephalitis Virus by Mosquitoes.
JO - Science
JF - Science
Y1 - 1978/02/24/
VL - 199
IS - 4331
M3 - Article
SP - 909
EP - 911
SN - 00368075
AB - Female Aedes albopictus and Aedes togoi mosquitoes infected with Japanese encephalitis virus either by intrathoracic inoculation or by ingestion of a virussucrose-erythrocyte mixture transmitted the virus to a small percentage of their F1 progeny. Adult F1 female Aedes albopictus thus infected transmitted the virus in turn to newly hatched chickens by feeding on them. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460830; ROSEN, LEON 1; TESH, ROBERT B. 1; JIH CHING LIEN 2; CROSS, JOHN H. 2; Affiliations: 1: Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii 96806; 2: U.S. Naval Medical Research Unit No. 2, Taipei, Taiwan; Issue Info: 2/24/1978, Vol. 199 Issue 4331, p909; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Darby, William J.
AU - Mason, Karl E.
T1 - Cultural Food Patterns and Nutrition.
JO - BioScience
JF - BioScience
Y1 - 1978/03//
VL - 28
IS - 3
M3 - Editorial
SP - 159
EP - 159
SN - 00063568
AB - The article presents the authors' opinion on cultural patterns of food and nutrition. According to the authors, concerns relating to food have become major public issues and have been pervaded by both political influences and religious emotionalism. They opine that serious scholars including Humanists and historians, have much to contribute to the clarification and understanding of food wants and cultural needs and in sorting value judgments related to present-day issues concerning food.
KW - Food -- Quality
KW - Nutrition
KW - Scholars
KW - Food science
N1 - Accession Number: 28050598; Darby, William J. 1; Mason, Karl E. 2; Affiliations: 1 : Nutrition Foundation, Inc. 489 Fifth Avenue New York, NY 10017; 2 : National Institute of Arthritis, Metabolism and Digestive Diseases National Institutes of Health Bethesda, MD 20014; Source Info: Mar1978, Vol. 28 Issue 3, p159; Subject Term: Food -- Quality; Subject Term: Nutrition; Subject Term: Scholars; Subject Term: Food science; Number of Pages: 1p; Document Type: Editorial; Full Text Word Count: 491
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Sohnle, Peter G.
AU - Kirkpatrick, Charles H.
T1 - EPIDERMAL PROLIFERATION IN THE DEFENSE AGAINST EXPERIMENTAL CUTANEOUS CANDIDIASIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/03//
VL - 70
IS - 3
M3 - Article
SP - 130
EP - 133
SN - 0022202X
AB - In previous studies we implicated scaling of the stratum corneum as being important in the clearance of experimental cutaneous Candida infections in guinea pigs. In this model the scaling response appeared to be intensified by delayed hypersensitivity reactions to Candida antigens and to be responsible for the more rapid clearance of infecting organisms by immune animals. The present studies were undertaken to quantitate the degree of epidermal proliferation in such Candida infections and to relate it to delayed hypersensitivity reactions as well as other types of inflammation. The two parameters of epidermal proliferation studied were incorporation of tritiated thymidine by basal cells and thickening of the malpighian layer; both were increased markedly in Candida-infected skin of immune animals and also to a lesser extent in Candida-infected skin of nonimmune animals. Positive delayed skin test responses to Candida antigens were associated with increased basal cell thymidine incorporation, but negative delayed responses were not. Inflammation caused by intradermal injection of irritants was also associated with increased basal cell thymidine incorporation. These results indicate that delayed hypersensitivity reactions in experimental cutaneous Candida infections act to increase the rate of basal cell turnover, primarily by producing increased inflammation in the lesions. The role of delayed hypersensitivity appears to be nonspecific, since other forms of inflammation are also capable of causing increased epidermal proliferation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANDIDIASIS
KW - EPIDERMIS
KW - INFECTION
KW - DELAYED hypersensitivity
KW - INFLAMMATION
KW - GUINEA pigs as laboratory animals
N1 - Accession Number: 12258536; Sohnle, Peter G. 1,2 Kirkpatrick, Charles H. 1,2; Affiliation: 1: The Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; The Infectious Disease Section, Medial Service, Veterans Administration Center, Wood (Milwaukee), Wisconsin 2: Laboratory of Clinical Investigation, National Institue of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A; Source Info: Mar1978, Vol. 70 Issue 3, p130; Subject Term: CANDIDIASIS; Subject Term: EPIDERMIS; Subject Term: INFECTION; Subject Term: DELAYED hypersensitivity; Subject Term: INFLAMMATION; Subject Term: GUINEA pigs as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12258536
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dunham, George S.
AU - Pacak, Milos G.
AU - Pratt, Arnold W.
T1 - Automatic Indexing of Pathology Data.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1978/03//
VL - 29
IS - 2
M3 - Article
SP - 81
EP - 90
SN - 00028231
AB - A procedure for automated indexing of pathology diagnostic reports at the National Institutes of Health is described. Diagnostic statements in medical English are encoded by computer into the Systematized Nomenclature of Pathology (SNOP). SNOP is a structured indexing language constructed by pathologists for manual indexing. It is of interest that effective automatic encoding can be based upon an existing vocabulary and code designed for manual methods. Morphosyntactic analysis, a simple syntax analysis, matching of dictionary entries consisting of several words, and synonym substitutions are techniques utilized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - PREVENTIVE medicine
KW - DISEASES
KW - SYNTAX (Grammar)
KW - ENVIRONMENTAL medicine
KW - IMMUNIZATION
N1 - Accession Number: 18063785; Dunham, George S. 1; Pacak, Milos G. 1; Pratt, Arnold W. 1; Affiliations: 1: Division of Computer Research and Technology, National institutes of Health, Bethesda, MD 20014.; Issue Info: Mar1978, Vol. 29 Issue 2, p81; Thesaurus Term: MEDICAL care; Subject Term: PREVENTIVE medicine; Subject Term: DISEASES; Subject Term: SYNTAX (Grammar); Subject Term: ENVIRONMENTAL medicine; Subject Term: IMMUNIZATION; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Feldman, Saul
T1 - CONFLICT & CONVERGENCE: THE MENTAL HEALTH PROFESSIONAL IN GOVERNMENT.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1978/03//Mar/Apr78
VL - 38
IS - 2
M3 - Article
SP - 139
EP - 144
PB - Wiley-Blackwell
SN - 00333352
AB - The article focuses on the role and influence of mental health professionals in government agencies in the U.S. Unlike general health care with its dependence on the private sector, the development of the mental health field largely has been the result of government action. Stimulated by the availability of state matching funds, local governments also have become heavily involved in mental health. The role of government as a major employer of mental health professionals is illustrated by a study of 10,000 mental health professionals whose training during the years 1948-1968 was supported at least in part by the National Institute of Mental Health. This dependence of the mental health field upon government is not reflected in the graduate education of mental health professionals. For the mental health professional who is also an administrator, there are several special attitudinal issues. The values of caring, support and therapy are often inconsistent with the exercise of power, the directive and perhaps authoritative stance sometimes necessary for successful administration.
KW - MENTAL health personnel
KW - PROFESSIONAL employees
KW - CIVIL service
KW - GOVERNMENT agencies
KW - GOVERNMENT policy
KW - MENTAL health
KW - MENTAL health policy
KW - PUBLIC health
KW - ATTITUDE (Psychology)
KW - UNITED States
N1 - Accession Number: 4613430; Feldman, Saul 1; Affiliations: 1: National Institute of Mental Health.; Issue Info: Mar/Apr78, Vol. 38 Issue 2, p139; Thesaurus Term: MENTAL health personnel; Thesaurus Term: PROFESSIONAL employees; Thesaurus Term: CIVIL service; Thesaurus Term: GOVERNMENT agencies; Thesaurus Term: GOVERNMENT policy; Subject Term: MENTAL health; Subject Term: MENTAL health policy; Subject Term: PUBLIC health; Subject Term: ATTITUDE (Psychology); Subject: UNITED States; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - MOUTSOPOULOS, HARALAMPOS M.
AU - CHUSED, THOMAS M.
AU - JOHNSON, ARMEAD H.
AU - KNUDSEN, BODIL
AU - MANN, DEAN L.
T1 - B Lymphocyte Antigens in Sicca Syndrome.
JO - Science
JF - Science
Y1 - 1978/03/31/
VL - 199
IS - 4336
M3 - Article
SP - 1441
EP - 1442
SN - 00368075
AB - All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436632; MOUTSOPOULOS, HARALAMPOS M. 1; CHUSED, THOMAS M. 1; JOHNSON, ARMEAD H. 2; KNUDSEN, BODIL 3; MANN, DEAN L. 3; Affiliations: 1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland 20014; 2: Division of Immunology, Duke University Medical Center, Durham, North Carolina 27710; 3: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1441; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOZAK, CHRISTINE
AU - ROWE, WALLACE P.
T1 - Genetic Mapping of Xenotropic Leukemia Virus-Inducing Loci in Two Mouse Strains.
JO - Science
JF - Science
Y1 - 1978/03/31/
VL - 199
IS - 4336
M3 - Article
SP - 1448
EP - 1449
SN - 00368075
AB - In genetic studies of C57BLI1O and BALBIc mice, inducibility of xenotropic murine leukemia virus from tissue cultures by treatment with 5-iododeoxyuridine shows single gene segregation ratios. In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-I isozyme locus, but the two may not be at allelic sites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436626; KOZAK, CHRISTINE 1; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1448; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MACDONALD, ROBERT L.
AU - NELSON, PHILLIP G.
T1 - Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture.
JO - Science
JF - Science
Y1 - 1978/03/31/
VL - 199
IS - 4336
M3 - Article
SP - 1449
EP - 1451
SN - 00368075
AB - The opiate etorphine depresses monosynaptic excitatory postsynaptic potentials (EPSP's) elicited in spinal cord cells by activation of dorsal root ganglion cells in murine neuronal cell culture. The depression is reversed by naloxone. Statistical analysis of the synaptic responses reveals that the opiate reduces EPSP quantal content at this synapse without altering quantal size. Therefore, the opiate action is presynaptic and affects transmitter release rather than postsynaptic responsiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436630; MACDONALD, ROBERT L. 1,2; NELSON, PHILLIP G. 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; 2: Department of Neurology, University of Virginia, Charlottesville 22901; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1449; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, J. L.
AU - NEALE, J. H.
AU - SMITH, JR., T. G.
AU - MACDONALD, R. L.
T1 - Opiate Peptide Modulation of Amino Acid Responses Suggests Novel Form of Neuronal Communication.
JO - Science
JF - Science
Y1 - 1978/03/31/
VL - 199
IS - 4336
M3 - Article
SP - 1451
EP - 1453
SN - 00368075
AB - Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action-of opiate peptide functionally distinct from the conventional neurotransmitter class of operation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436614; BARKER, J. L. 1; NEALE, J. H. 2; SMITH, JR., T. G. 1; MACDONALD, R. L. 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, and Department of Biology, Georgetown University, Washington, D.C.; 3: Laboratory of Developmental Neutrobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 3/31/1978, Vol. 199 Issue 4336, p1451; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Garn, Stanley M.
AU - Shaw, Helen A.
AU - McCabe, Kinne D.
T1 - Effect of maternal smoking on hemoglobins and hematocrits of the newborn.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1978/04//
VL - 31
IS - 4
M3 - Article
SP - 557
EP - 558
SN - 00029165
N1 - Accession Number: 94355773; Garn, Stanley M. 1; Shaw, Helen A. 1; McCabe, Kinne D. 2; Affiliations: 1: Center for Human Growth and Development and Nutrition Unit, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109; 2: The Collaborative Perinatal Project, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: Apr1978, Vol. 31 Issue 4, p557; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hunninghake, G. W.
AU - Haynes, B. F.
AU - Parrillo, J. E.
AU - Fauci, A. S.
T1 - Comparison of the relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/04//
VL - 32
IS - 1
M3 - Article
SP - 186
EP - 191
PB - Wiley-Blackwell
SN - 00099104
AB - The relative cytotoxic effector cell capabilities and the proportions of cells bearing various surface markers in human tonsil and peripheral blood mononuclear cells has been studied. The peripheral blood contained a substantial proportion of monocytes (22± 2'9%) compared to tonsil cell suspensions (25±0.3%). The percentages of T lymphocytes was significantly higher in the blood than in the tonsil (P < 0.01); however, the percentages of cells forming rosettes with 7S EA were not significantly different in each group (P>0.5). Mitogen-induced cellular cytotoxicity by blood and tonsil mononuclear cells against Chang cells was proportional to the percentages of T lymphocytes in these cell suspensions, and both antibody-dependent and mitogen-induced cellular cytoxicity against sheep red blood cells was proportional to the percentages of monocytes in these suspensions. Tonsil mononuclear cell suspensions were incapable of mediating antibody-dependent cellular cytotoxicity against Chang cells, whereas blood mononuclear cells functioned normally. These findings are in contrast to the findings of similar percentages of Fc receptor-positive lymphocytes in blood and tonsil mononuclear cell suspensions. Previous studies have shown that the effector cells against antibody-coated Chang cells are Fc receptor-positive lymphocytes. These studies show that in the case of cytotoxicity mediated by an Fc receptor-bearing lymphoid cell, there may be a clear discrepancy between the relative proportions of Fc-bearing lymphoid cells in different organs and the relative levels of cytotoxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TONSILS
KW - MONOCYTES
KW - LEUCOCYTES
KW - T cells
KW - CELL suspensions
KW - CELL culture
N1 - Accession Number: 16108831; Hunninghake, G. W. 1 Haynes, B. F. 1 Parrillo, J. E. 1 Fauci, A. S. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr1978, Vol. 32 Issue 1, p186; Subject Term: TONSILS; Subject Term: MONOCYTES; Subject Term: LEUCOCYTES; Subject Term: T cells; Subject Term: CELL suspensions; Subject Term: CELL culture; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harford, Thomas C.
AU - Blane, Howard T.
AU - Crafetz, Morris E.
T1 - PSYCHOLINGUISTIC CORRELATES OF LANGUAGE PREDICTABILITY IN PSYCHIATRIC INTERVIEWS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1978/04//
VL - 34
IS - 2
M3 - Article
SP - 501
EP - 505
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article presents information on language predictability in psychiatric interviews. The present study seeks to replicate the previous finding of shifts in predictability in initial psychiatric interviews and its correlation with post-interview ratings. In addition, correlations between several measures of anxiety and immediacy with shifts in predictability are examined. It is hypothesized that decreases in predictability as an interview progresses will be accompanied by an increase in anxiety tension, less common word usage, and immediacy. Samples of speech of patients were obtained from 14 tape-recorded initial intake interviews in an outpatient clinic of a general hospital. Two speech samples, of 105 words each, were extracted from the initial and terminal portions of each interview.
KW - INTERVIEWING in psychiatry
KW - INTERVIEWING in mental health
KW - PSYCHOTHERAPY
KW - STRESS (Psychology)
KW - ANXIETY
KW - PATIENTS
N1 - Accession Number: 15845365; Harford, Thomas C. 1 Blane, Howard T. 2 Crafetz, Morris E. 3; Affiliation: 1: National Institute of Alcohol Abuse and Alcoholism. 2: University of Pittsburgh. 3: Johns Hopkins University.; Source Info: Apr1978, Vol. 34 Issue 2, p501; Subject Term: INTERVIEWING in psychiatry; Subject Term: INTERVIEWING in mental health; Subject Term: PSYCHOTHERAPY; Subject Term: STRESS (Psychology); Subject Term: ANXIETY; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaoita, Hideo
AU - Foidart, Jean-Michel
AU - Katz, Stephen I.
T1 - LOCALIZATION OF THE COLLAGENOUS COMPONENT IN SKIN BASEMENT MEMBRANE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/04//
VL - 70
IS - 4
M3 - Article
SP - 191
EP - 193
SN - 0022202X
AB - Antibodies to type IV collagen were produced by immunizing rabbits with a basement membrane collagen obtained from a transplantable mouse tumor. Using specifically purified antibodies, type IV collagen was localized ultrastructurally to the basal lamina part of the basement membrane zone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLAGEN
KW - SKIN
KW - BASAL lamina
KW - IMMUNOGLOBULINS
KW - IMMUNIZATION
KW - RABBITS as laboratory animals
KW - TUMORS
N1 - Accession Number: 12541313; Yaoita, Hideo 1,2 Foidart, Jean-Michel 1,2 Katz, Stephen I. 1,2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr78, Vol. 70 Issue 4, p191; Subject Term: COLLAGEN; Subject Term: SKIN; Subject Term: BASAL lamina; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNIZATION; Subject Term: RABBITS as laboratory animals; Subject Term: TUMORS; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12541313
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Otani, T. T.;
AU - Briley, M. R.;
T1 - Effect of acylated amino acids and acylated amino acid analogs on microbial antitumor screen
CT - Effect of acylated amino acids and acylated amino acid analogs on microbial antitumor screen
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1978/04/01/
VL - 67
IS - Apr
SP - 520
EP - 526
SN - 00223549
AD - Nucleic Acids Sec., Lab. of Pathophysiology, National Cancer Institute, NIH, Bethesda, MD 20014
N1 - Accession Number: 16-1847; Language: English; References: 17; Journal Coden: JPMSAE; Section Heading: Microbiology; Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2 - A series of N-acetyl, N-propionyl and N-chloracetyl derivatives of amino acids and amino acid analogs was tested for growth inhibitory activity using a Lactobacillus casei system as a prescreen for possible antitumor activity. The chloracetyl derivatives, especially those of essential amino acids and of their analogs, showed modest but pharmacologically significant inhibition, while those of nonessential amino acids exhibited no activity.
KW - Amino acids--and derivatives--effects, antitumor, Lactobacillus casei screen;
KW - Structure-activity relationships--amino acids--and derivatives, antitumor effects, Lactobacillus casei screen;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-42915-021
AN - 2013-42915-021
AU - Yarrow, Leon J.
T1 - Review of Temperament and development.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1978/04//
VL - 48
IS - 2
SP - 359
EP - 360
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42915-021. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Emotional States; Persistence; Personality Development. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Reviewed Item: Thomas, Alexander; Chess, Stella. Temperament and development=270 pp. $13.50. Brunner/Mazel, New York; 1977. Page Count: 2. Issue Publication Date: Apr, 1978.
AB - Reviews the book, Temperament and Development by Alexander Thomas and Stella Chess (1977). The authors attempted to document individual differences in what were called primary reaction patterns early in infancy. The book distinguishes nine categories of temperment: activity, rhythmicity, adaptability, approach/withdrawal, threshold of responsiveness, intensity of reaction, mood, distractibility and persistence. A major theme running through this book is that the organism and environment are separable only as a convenience for study. The authors stress the reciprocal relationship between characteristics of the child and environmental opportunities, demands, and stresses. Throughout the book, the discussion is reasoned and the authors do not make extreme claims for the primacy of temperamental attributes or reject the importance of the environment. With regard to early environmental determinism, the authors cite data from diverse sources that question the simple, long-held, and cherished conviction that the impact of early experience is irreversible. The ideas presented by the authors are provocative and they stimulate our thinking about the term and emphasize the need for clarification of the concept. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - temperament
KW - adolescent development
KW - personality growth
KW - mood distractibility
KW - persistence
KW - 1978
KW - Adolescent Development
KW - Emotional States
KW - Persistence
KW - Personality Development
KW - 1978
U2 - Thomas, Alexander; Chess, Stella. (1977); Temperament and development; 270 pp. $13.50. Brunner/Mazel, New York
DO - 10.1037/h0098959
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SPRING, KENNETH R.
AU - HOPE, ARVID
T1 - Size and Shape of the Lateral Intercellular Spaces in a Living Epithelium.
JO - Science
JF - Science
Y1 - 1978/04/07/
VL - 200
IS - 4337
M3 - Article
SP - 54
EP - 58
SN - 00368075
AB - The lateral intercellular spaces of Necturus gallbladder epithelium were seen and measured while the living tissue was perfused in a new chamber. The compliance of the lateral cell membranes was calculated from the measured pressure-volume characteristics of the lateral intercellular spaces. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87437122; SPRING, KENNETH R. 1; HOPE, ARVID 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 4/7/1978, Vol. 200 Issue 4337, p54; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 84007916
T1 - Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy.
AU - Peylan-Ramu, Nili
AU - Poplack, David G.
AU - Pizzo, Philip A.
AU - Adornato, Bruce T.
AU - Di Chiro, Giovanni
AU - Peylan-Ramu, N
AU - Poplack, D G
AU - Pizzo, P A
AU - Adornato, B T
AU - Di Chiro, G
Y1 - 1978/04/13/
N1 - Accession Number: 84007916. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Reynolds Adolescent Depression Scale (RADS). NLM UID: 0255562.
KW - Methotrexate -- Administration and Dosage
KW - Tomography, X-Ray Computed
KW - Meningeal Neoplasms -- Prevention and Control
KW - Cytarabine -- Administration and Dosage
KW - Leukemia, Lymphocytic -- Therapy
KW - Brain
KW - Brain -- Radiation Effects
KW - Child, Preschool
KW - Cytarabine -- Therapeutic Use
KW - Injections, Intraspinal
KW - Adolescence
KW - Leukemia, Lymphocytic -- Drug Therapy
KW - Infant
KW - Leukemia, Lymphocytic -- Radiotherapy
KW - Methotrexate -- Therapeutic Use
KW - Child
KW - Human
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Randomized Controlled Trials
KW - Psychological Tests
SP - 815
EP - 818
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 298
IS - 15
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - Thirty-two asymptomatic patients with acute lymphocytic leukemia, who had received prophylactic cranial radiation (2400 rads) and either intrathecal methotrexate or cytosine arabinoside were studied by computed tomography of the brain 19 to 67 months after initiation of prophylaxis. Seventeen of 32 (53 per cent) had one or more abnormal findings. Dilatation of the ventricles (eight patients) and widening of the subarachnoid spaces (nine patients) were equally distributed among patients in both intrathecal-chemotherapy groups. Areas of decreased attenuation coefficient (hypodense, abnormally radiolucent regions) (four patients) and intracerebral calcification (one patient)--lesions previously described in methotrexate leukoencephalopathy--were found only in those who had received intrathecal methotrexate. Mild central-nervous-system dysfunction was detected in seven patients but did not correlate with the presence of tomographic abnormalities. Nevertheless, these tomographic findings may represent preclinical lesions. The unexpectedly high prevalence of such abnormalities contrasts with the essentially normal tomographic findings in a control group with acute lymphocytic leukemia who received no central-nervous-system prophylaxis. These results suggest that alternative approaches to such prophylaxis be considered.
SN - 0028-4793
AD - From the Pediatric Oncology Branch, National Cancer Institute, and the Medical Neurology Branch and Section on Neuroradiology, Neurosurgery Branch, National Institute of Neurological and Communicative Disorders and Stroke (address reprint requests to Dr. Poplack at Bldg. 10, Rm. 3B–03, National Institutes of Health, Bethesda, MD 20014).
U2 - PMID: 273143.
DO - 10.1056/NEJM197804132981504
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Phillips, Don R.
AU - DiMarco, Aurelio
AU - Zunino, Franco
T1 - The Interaction of Daunomycin with Polydeoxynucleotides.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/04/17/
VL - 85
IS - 2
M3 - Article
SP - 487
EP - 492
PB - Wiley-Blackwell
SN - 00142956
AB - The ability of daunomycin to bind to various DNA polymers has been studied by thermal denaturation, spectrophotometric analysis and inhibition of the polymerisation reactions catalysed by Escherichia coli DNA polymerase 1 and rat liver DNA polymerase α. The quantitative binding measurements revealed that the antibiotic binds tightly to all synthetic polydeoxynucleotides studied. The results demonstrated that daunomycin can bind with equal affinity to dG · dC or dA · dT base-paired sequences. However, the number of binding sites per nucleotide for poly(dA) · poly(dT) is significantly lower than that found for poly(dA-dT) · poly(dA-dT), thus indicating an appreciable preference of the drug for the alternating copolymer. The inactivation of the template properties of the synthetic DNA polymers in the DNA polymerase system is consistent with their daunomycin binding ability. However, a lack of correlation was observed between the drug binding ability of different DNA polymers and the binding-induced stabilisation of the double helix to heat denaturation. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DAUNOMYCIN
KW - POLYMERS
KW - ENZYMES
KW - NUCLEIC acids
KW - BINDING sites (Biochemistry)
KW - BIOCHEMISTRY
N1 - Accession Number: 13645366; Phillips, Don R. 1 DiMarco, Aurelio 1 Zunino, Franco 1; Affiliation: 1: Department of Biochemistry, La Trobe and Division of Experimental Oncology B, National Cancer Institute, Milan; Source Info: 4/17/78, Vol. 85 Issue 2, p487; Subject Term: DAUNOMYCIN; Subject Term: POLYMERS; Subject Term: ENZYMES; Subject Term: NUCLEIC acids; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenberg, Hagai
AU - Singer, Maxine
AU - Rosenberg, Martin
T1 - Highly Reiterated Sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN.
JO - Science
JF - Science
Y1 - 1978/04/28/
VL - 200
IS - 4340
M3 - Article
SP - 394
EP - 402
SN - 00368075
AB - A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546542; Rosenberg, Hagai 1,2; Singer, Maxine 3; Rosenberg, Martin 3; Affiliations: 1: Visiting Fellow, National Cancer Institute, Bethesda, Maryland 20014,; 2: Israel Institute for Biological Research, Prime Minister's Office, Ness Ziona P.O.B. 19 Israel; 3: Laboratory of Biochemistry and Laboratory of Molecular Biology, respectively, National Cancer Society; Issue Info: 4/28/1978, Vol. 200 Issue 4340, p394; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DES RoSIERS, M. H.
AU - SAKURADA, O.
AU - JEHLE, J.
AU - SHINOHARA, M.
AU - KENNEDY, C.
AU - SOKOLOFF, L.
T1 - Functional Plasticity in the Immature Striate Cortex of the Monkey Shown by the ["C]Deoxyglucose Method.
JO - Science
JF - Science
Y1 - 1978/04/28/
VL - 200
IS - 4340
M3 - Article
SP - 447
EP - 449
SN - 00368075
AB - Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life . [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546521; DES RoSIERS, M. H. 1; SAKURADA, O. 1; JEHLE, J. 1; SHINOHARA, M. 1; KENNEDY, C. 2; SOKOLOFF, L. 3; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C. 20007; 3: Laboratory of Cerebral Metabolism, National Institute ofMental Health; Issue Info: 4/28/1978, Vol. 200 Issue 4340, p447; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leong, D.
AU - Coe, J.E.
T1 - Metabolism of homologous and heterologous serum proteins in garter snakes ( Thamnophis ordinoides ).
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 931
EP - 937
PB - Wiley-Blackwell
SN - 00192805
AB - The half life (T½) of serum immunoglobulin (Ig) and albumin from snakes and mammals were determined in both garter snakes (Thamnophis ordinoides) and mice (Mus musculus). Metabolism of serum proteins in snakes was similar to mammalian protein metabolism in that homologous serum albumin had shorter T½ (16 days) than IgG (38 days). Also, reptilian and mammalian serum proteins had a relatively longer T½ when injected into closely related species. Thus mammalian serum Ig (rabbit gamma globulin (RGG)) had a shorter T½ (6.3 days) in snake than did homologous snake IgG (38 days), whereas in mice, RGG had a longer T½ (3.8 days) than snake Ig (0.9 days). Differences between metabolism of homologous and heterologous albumins were apparent only in snakes in which the T½. of homologous albumin was approximately 8-fold greater than mammalian albumin. These results indicate that metabolism of both Ig and albumin in snakes is regulated by specific receptors whereas albumin receptors have been difficult to demonstrate in mammals. The results of this study suggest that one of the factors determining the metabolism of a protein is its foreignness to the host perhaps because of receptor cross reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD proteins
KW - GARTER snakes
KW - THAMNOPHIS ordinoides
KW - IMMUNOGLOBULINS
KW - PROTEIN metabolism
KW - MAMMALS
KW - SERUM
KW - ALBUMINS
N1 - Accession Number: 13930713; Leong, D. 1 Coe, J.E. 1; Affiliation: 1: Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Moutain Laboratory, Hamilton, Montana, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p931; Subject Term: BLOOD proteins; Subject Term: GARTER snakes; Subject Term: THAMNOPHIS ordinoides; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEIN metabolism; Subject Term: MAMMALS; Subject Term: SERUM; Subject Term: ALBUMINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Johannesen, Lynne
AU - Inman, J.K.
AU - Merchant, B.
T1 - Specificity of murine delayed-type hypersensitivity to conjugates of large or small haptens on protein carriers bearing lipid groups.
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 947
EP - 954
PB - Wiley-Blackwell
SN - 00192805
AB - Delayed-type hypersensitivity (DH) in the mouse was provoked with different haptencarrier complexes mixed with the cationic, surfaceactive lipid, dimethyl dioctadecyl ammonium bromide (DDA). DH was measured as footpad swelling.Conjugates of bovine serum albumin (BSA) with the small haptens dinitrophenyl (DNP), 'arsonate'(ARS) and 'sulphonate' (SULPH) served to generate strong DH reactions towards the homologous antigen. Insertion of a tripeptide spacer between the hapten and carrier resulted in lower DH reactivity. Optimal dosages and optimal time intervals between sensitization and DH elicitation were determined for the enlarged hapten-carrier complexes. Cyclophosphamide (CY) treatment, before priming with complexes mixed with DDA, caused a 5-6 day delay in the expression of DH but failed to evoke enhanced DH for any of the antigens tested. A broad array of cross reactions between small and enlarged hapten-carrier complexes showed a relative lack of specificity in these DH responses. The results are compared with others reported in the literature and are explained mainly by the effects of electrostatically bound lipid groups of DDA in the sensitizing conjugates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DELAYED hypersensitivity
KW - MICE
KW - SERUM albumin
KW - HAPTENS
KW - ANTIGENS
KW - CARRIER proteins
KW - BROMIDES
N1 - Accession Number: 13932691; Snippe, H. 1 Johannesen, Lynne 1 Inman, J.K. 1 Merchant, B. 1; Affiliation: 1: Division and Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p947; Subject Term: DELAYED hypersensitivity; Subject Term: MICE; Subject Term: SERUM albumin; Subject Term: HAPTENS; Subject Term: ANTIGENS; Subject Term: CARRIER proteins; Subject Term: BROMIDES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Andrews, Alan D.
AU - Barrett, Susanna F.
AU - Yoder, Frank W.
AU - Robbins, Jay H.
T1 - COCKAYNE'S SYNDROME FIBROBLASTS HAVE INCREASED SENSITIVITY TO ULTRAVIOLET LIGHT BUT NORMAL RATES OF UNSCHEDULED DNA SYNTHESIS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/05//
VL - 70
IS - 5
M3 - Report
SP - 237
EP - 239
SN - 0022202X
AB - Cockayne's syndrome is a form of cachectic dwarfism characterized by acute sun sensitivity and numerous other abnormalities of many organ systems. We studied fibroblasts from 9 Cockayne's syndrome patients to determine if their fibroblasts had abnormal post-ultraviolet light colony-for using ability or abnormal ultraviolet light-induced unscheduled DNA synthesis. The fibroblast strains from all the patients had markedly decreased post-ultraviolet light colony-forming ability in comparison with fibroblasts from control donors. Since this increased ultraviolet light sensitivity is propagable in vitro, it may be a manifestation of, or be closely associated with, the inherited genetic defect of this autosomal recessive disease. However, the patients' fibroblasts had normal rates of ultraviolet light-induced unscheduled DNA synthesis. Thus, unlike the UV sensitivity of DNA excision repair-deficient xeroderma pigmentosum strains, the UV sensitivity of Cockayne's syndrome strains is not related to abnormal DNA excision repair, at least to the extent that this repair process is reflected by rates of ultraviolet light-induced unscheduled DNA synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DWARFISM
KW - DISEASES
KW - SKIN abnormalities
KW - FIBROBLASTS
KW - GROWTH disorders
KW - GENES
N1 - Accession Number: 12541383; Andrews, Alan D. 1 Barrett, Susanna F. 1 Yoder, Frank W. 1 Robbins, Jay H. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: May78, Vol. 70 Issue 5, p237; Subject Term: DWARFISM; Subject Term: DISEASES; Subject Term: SKIN abnormalities; Subject Term: FIBROBLASTS; Subject Term: GROWTH disorders; Subject Term: GENES; Number of Pages: 3p; Document Type: Report
L3 - 10.1111/1523-1747.ep12541383
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraemer, Kenneth H.
T1 - Photochemical and Photobiological Reviews (Book).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/05//
VL - 70
IS - 5
M3 - Book Review
SP - 299
EP - 300
SN - 0022202X
AB - Reviews the book "Photochemical and Photobiological Reviews," by Kendric C. Smith.
KW - PHOTOBIOLOGY
KW - NONFICTION
KW - SMITH, Kendrick C.
KW - PHOTOCHEMICAL & Photobiological Reviews (Book)
N1 - Accession Number: 12541576; Kraemer, Kenneth H. 1; Affiliation: 1: Chemistry Branch, National Cancer Institute.; Source Info: May78, Vol. 70 Issue 5, p299; Subject Term: PHOTOBIOLOGY; Subject Term: NONFICTION; Reviews & Products: PHOTOCHEMICAL & Photobiological Reviews (Book); People: SMITH, Kendrick C.; Number of Pages: 2p; Document Type: Book Review
L3 - 10.1111/1523-1747.ep12541576
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yoon Sang Cho-Chung
AU - Bodwin, Jeffrey S.
AU - Clair, Timothy
T1 - Cyclic AMP-Binding Proteins: Inverse Relationship with Estrogen-Receptors in Hormone-Dependent Mammary Tumor Regression.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/05/02/
VL - 86
IS - 1
M3 - Article
SP - 51
EP - 60
PB - Wiley-Blackwell
SN - 00142956
AB - Dimethylbenzanthracene-induced rat mammary carcinomas possess activities binding cyclic adenosine 3′:5′-monophosphate (cAMP) and estrogen. When dimethylbenzanthracene-induced tumors regress after ovariectomy of the host, a change in the specific binding of cAMP and estrogen occurs in the tumors. Six days after ovariectomy, cAMP binding increases 5-fold in the nuclei and 2-fold in the cytosol of tumors, while nuclear and cytoplasmic estrogen binding decreases by 80% and 50%, respectively. These changes in activities binding cAMP and estrogen are detectable within I day after ovariectomy and the changes are reversed when resumption of tumor growth is induced by the injection of 17β-estradiol. When dimethylbenzanthracene-induced tumors fail to regress after ovariectomy, the change in activities binding cAMP and estrogen does not occur. Significant increases in the cAMP level as well as in adenylate cyclase and cAMP-phosphodiesterase activities are also found in the regressing tumors. Concomitant with the increase of cAMP-binding activity is an increase in historic kinase activity in the regressing tumor. These data suggest the involvement of cAMP in the growth control of a hormone-dependent mammary tumor. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMARY glands -- Cancer
KW - RATS
KW - ANATOMY
KW - ADENOSINE
KW - CYCLIC adenylic acid
KW - ESTROGEN
KW - OVARIECTOMY
KW - TUMORS -- Growth
KW - RATS as laboratory animals
N1 - Accession Number: 13648181; Yoon Sang Cho-Chung 1 Bodwin, Jeffrey S. 1 Clair, Timothy 1; Affiliation: 1: Laboratory of Pathophysiology, National Cancer Institute, National Institute of Health, Bethesda, Maryland; Source Info: 5/2/78, Vol. 86 Issue 1, p51; Subject Term: MAMMARY glands -- Cancer; Subject Term: RATS; Subject Term: ANATOMY; Subject Term: ADENOSINE; Subject Term: CYCLIC adenylic acid; Subject Term: ESTROGEN; Subject Term: OVARIECTOMY; Subject Term: TUMORS -- Growth; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - COSTA, JONATHAN L.
AU - JOY, DAVID C.
AU - MAHER, DENNIS M.
AU - KIRK, KENNETH L.
AU - HUI, S. W.
T1 - Fluorinated Molecule as a Tracer: Difluoroserotonin in Human Platelets Mapped by Electron Energy-Loss Spectroscopy.
JO - Science
JF - Science
Y1 - 1978/05/05/
VL - 200
IS - 4341
M3 - Article
SP - 537
EP - 539
SN - 00368075
AB - The intracellular distribution of fluorine has been delineated in human platelets incubated with 4,6-difluoroserotonin, utilizing a scanning-transmission electron microscope equipped with an energy-loss spectrometer. Discrete intracellular structures corresponding in location to dense bodies contained high concentrations of fluorine. Electron energy-loss spectroscopy, which apparently can detect less than 10-20 gram of fluorine in an area of 10 square nanometers, can thus localize fluorinated tracer molecules with biological activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546550; COSTA, JONATHAN L. 1; JOY, DAVID C. 2; MAHER, DENNIS M. 2; KIRK, KENNETH L. 3; HUI, S. W. 4; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Bell Laboratories, Murray Hill, New Jersey 07974; 3: Laboratory ofChemistry, National Institute ofArthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 4: Department ofBiophysics, Roswell Park Memorial Institute, Buffalo, New York 14263; Issue Info: 5/5/1978, Vol. 200 Issue 4341, p537; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHICHI, HITOSHI
AU - GAASTERLAND, DOUGLAS E.
AU - JENSEN, NANCY M.
AU - NEBERT, DANIEL W.
T1 - Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen.
JO - Science
JF - Science
Y1 - 1978/05/05/
VL - 200
IS - 4341
M3 - Article
SP - 539
EP - 541
SN - 00368075
AB - The Ahb/Ahb homozygous and the Ahb/Ahd heterozygous inbred mouse strains from the (C57BL/6)(DBA/2)F1 x DBA/2 backcross are genetically responsive to 3-methylcholanthrene. They both also develop, within 6 hours after a large intraperitoneal dose of acetaminophen, an irreversible opacity in the anterior portion of the lens. Such cataract formation does not occur in similarly treated nonresponsive inbred strains or nonresponsive Ahd/Ahd individuals from the same backcross. Differences in acetaminophen metabolism and toxicity are associated with the Ah locus in the mouse, and differences in heritability at the Ah locus exist in the human. Our ophthalmologic findings may be important clinically to certain patients receiving either a single large overdose of this drug or high doses over a long period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546590; SHICHI, HITOSHI 1; GAASTERLAND, DOUGLAS E. 2; JENSEN, NANCY M. 3; NEBERT, DANIEL W. 3; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; 2: Clinical Branch, National Eye Institute; 3: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 5/5/1978, Vol. 200 Issue 4341, p539; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MACDONALD, ROBERT L.
AU - BARKER, JEFFERY L.
T1 - Different Actions of Anticonvulsant and Anesthetic Barbiturates Revealed by Use of Cultured Mammalian Neurons.
JO - Science
JF - Science
Y1 - 1978/05/19/
VL - 200
IS - 4343
M3 - Article
SP - 775
EP - 777
SN - 00368075
AB - Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the γ-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519322; MACDONALD, ROBERT L. 1; BARKER, JEFFERY L. 2; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20014, and Department of Neurology, University of Virginia, Charlottesville 22903; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 5/19/1978, Vol. 200 Issue 4343, p775; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Moment, Gairdner
T1 - Author's Reply.
JO - BioScience
JF - BioScience
Y1 - 1978/06//
VL - 28
IS - 6
M3 - Letter
SP - 364
EP - 364
SN - 00063568
AB - A response by Gairdner B. Moment to two letters to the editor about his editorial "Roots and the Biologist," concerning author Alex Haley's concept of ancestry in his book "Roots," in the September 1977 issue is presented.
KW - Letters to the editor
KW - Genealogy
N1 - Accession Number: 28050665; Moment, Gairdner 1; Affiliations: 1 : Gerontology Research Center, National Institute on Aging, Bethesda, MD 20014; Source Info: Jun1978, Vol. 28 Issue 6, p364; Subject Term: Letters to the editor; Subject Term: Genealogy; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 590
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Katz, P.
AU - Fauci, A. S.
T1 - Inhibition of polyclonal B-cell activation by suppressor monocytes in patients with sarcoidosis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/06//
VL - 32
IS - 3
M3 - Article
SP - 554
EP - 562
PB - Wiley-Blackwell
SN - 00099104
AB - The present study employed a direct plaque-forming cell (PFC) assay following pokeweed mitogen (PWM) induced polyclonal activation of B lymphocytes in sarcoidosis to evaluate the in vitro humoral immune response in this disease and to delineate the immunoregulation of this response. Sarcoidosis lymphocytes had a suppressed PFC response to polyclonal activation. but were unable to suppress normal B-cell PFC responses in allogeneic co-cultures. Removal of a cell type, which was corticosteroid-resistant, radio-resistant, adherent and a non-T cell, from sarcoidosis mononuclear cell suspensions reversed the suppressed PFC response, indicating the presence of a suppressor monocyte. Thus in vitro suppressor cell activity has now been demonstrated in this disease, which is characterized by multiple immunological aberrancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SARCOIDOSIS
KW - B cells
KW - MONOCYTES
KW - LYMPHOPROLIFERATIVE disorders
KW - PSEUDOTUBERCULOSIS
KW - PATIENTS
N1 - Accession Number: 16288679; Katz, P. 1 Fauci, A. S. 1; Affiliation: 1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jun1978, Vol. 32 Issue 3, p554; Subject Term: SARCOIDOSIS; Subject Term: B cells; Subject Term: MONOCYTES; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: PSEUDOTUBERCULOSIS; Subject Term: PATIENTS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 83992750
T1 - Long-term anatomic fate of coronary-artery bypass grafts and functional status of patients five years after operation.
AU - Seides, Stuart F.
AU - Borer, Jeffrey S.
AU - Kent, Kenneth M.
AU - Rosing, Douglas R.
AU - McIntosh, Charles L.
AU - Epstein, Stephen E.
AU - Seides, S F
AU - Borer, J S
AU - Kent, K M
AU - Rosing, D R
AU - McIntosh, C L
AU - Epstein, S E
Y1 - 1978/06//6/ 1/1978
N1 - Accession Number: 83992750. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Functional Living Index: Cancer (FLIC) (Schipper et al). NLM UID: 0255562.
KW - Coronary Artery Bypass
KW - Angina Pectoris
KW - Coronary Disease
KW - Coronary Angiography
KW - Prospective Studies
KW - Time Factors
KW - Recurrence
KW - Postoperative Complications
KW - Clinical Assessment Tools
SP - 1213
EP - 1217
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 298
IS - 22
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - To assess long-term results, coronary and graft angiography was performed 53 to 84 months after operation in 22 of 30 consecutive patients who had undergone coronary-artery bypass grafting before 1973, and who had at least one graft patent at an early (three to nine months) postoperative study. Of the 33 grafts, 31 were patent at late study. All patients had severe symptoms before operation. Of 16 who became asymptomatic early after operation, angina pectoris later redeveloped in 11. Progression of disease in ungrafted vessels accounted for symptomatic deterioration in nine of these 11 patients. We conclude that most grafts patent several months after operation remain so for at least 4 1/2 years, and that although most patients improve symptomatically after operation, symptomatic deterioration is common in the succeeding years and is most often due to progression of disease in ungrafted vessels.
SN - 0028-4793
AD - From the Cardiology and Surgery Branches, National Heart, Lung, and Blood Institute (address reprint requests to Dr. Seides at the Cardiology Branch, Bldg. 10, Rm. 7B–15, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20014).
U2 - PMID: 306575.
DO - 10.1056/NEJM197806012982201
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Busis, NEIL A.
AU - WEIGHT, FORREST F.
AU - SMITH, PETER A.
T1 - Synaptic Potentials in Sympathetic Ganglia: Are They Mediated by Cyclic Nucleotides.
JO - Science
JF - Science
Y1 - 1978/06/02/
VL - 200
IS - 4345
M3 - Article
SP - 1079
EP - 1081
SN - 00368075
AB - Abstract. The hypothesis that cyclic nucleotides are intracellular second messengers mediating the generation of synaptic potentials was studied in the sympathetic ganglia of the bullfrog. Synaptic potentials and the effect of administering cyclic nucleotides and agents which affect cyclic nucleotide metabolism were recorded by the sucrose gap technique. The administration of adenosine 3',5'-monophosphate (cyclic AMP), guanosine 3',5'-monophosphate (cyclic GMP), or several of their derivatives produced little or no change in membrane potential. Prostaglandin E1 did not block the generation of postsynaptic potentials. Theophylline produced membrane effects that were different from those associated with postsynaptic potential generation; it also reduced the slow excitatory postsynaptic potential (EPSP) and potentiated the slow inhibitory postsynaptic potential (IPSP). The administration of papaverine, however, reduced both the slow EPSP and the slow IPSP. Although synaptic stimulation increases both cyclic GMP and cyclic AMP in these neurons, these results raise the possibility that these cyclic nucleotides may have functional roles other than mediation of synaptic potentials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477254; Busis, NEIL A. 1; WEIGHT, FORREST F. 1; SMITH, PETER A. 1; Affiliations: 1: Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 6/2/1978, Vol. 200 Issue 4345, p1079; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YOSHIKAMI, S.
AU - NOLL, G. N.
T1 - Isolated Retinas Synthesize Visual Pigments from Retinol Congeners Delivered by Liposomes.
JO - Science
JF - Science
Y1 - 1978/06/23/
VL - 200
IS - 4348
M3 - Article
SP - 1393
EP - 1395
SN - 00368075
AB - Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Liposomes can protect oxygen-sensitive, lipid-solube substance and deliver them to living cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460241; YOSHIKAMI, S. 1; NOLL, G. N. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014; Issue Info: 6/23/1978, Vol. 200 Issue 4348, p1393; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 83994514
T1 - Effects of coronary-artery bypass on global and regional left ventricular function during exercise.
AU - Kent, Kenneth M.
AU - Borer, Jeffry S.
AU - Green, M. V.
AU - Bacharach, Stephen L.
AU - McIntosh, C. L.
AU - Conkle, D. M.
AU - Epstein, Stephen E.
AU - Kent, K M
AU - Borer, J S
AU - Bacharach, S L
AU - Epstein, S E
Y1 - 1978/06/29/
N1 - Accession Number: 83994514. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Exercise of Self-Care Agency Scale (ESCA) (Kearney and Fleischer); Global Assessment of Functioning Scale (GAF); Defining Issues Test (DIT) (Rest). NLM UID: 0255562.
KW - Coronary Artery Bypass
KW - Exertion
KW - Heart -- Physiology
KW - Angina Pectoris -- Surgery
KW - Coronary Vessels
KW - Cineangiography
KW - Aged
KW - Myocardial Contraction
KW - Coronary Disease
KW - Female
KW - Cardiac Output
KW - Blood Pressure
KW - Time Factors
KW - Heart Rate
KW - Technetium
KW - Adult
KW - Male
KW - Radionuclide Imaging
KW - Coronary Angiography
KW - Middle Age
KW - Electrocardiography
KW - Exercise of Self-Care Agency Scale
KW - Scales
SP - 1434
EP - 1439
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 298
IS - 26
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - To determine the effect of coronary revascularization on exercise-induced abnormalities of left ventricular-ejection fraction and regional contraction, we obtained electrocardiograph-gated 99mTc radionuclide cineangiograms before and after operation in 23 consecutive patients. At rest, their average ejection fraction remained unchanged: 51 +/- 3 versus 54 +/- 4 per cent (+/- S.E.M.). However, 17 of the patients showed improvement of ejection fraction during postoperative exercise (increase of 51 per cent). The remaining six patients had no change or a decreased ejection fraction during exercise. All patients with improved ejection fractions during exercise were symptomatically improved. No improvement of regional function occurred at rest, but improvement did occur in regions of exercise-induced dysfunction. Although coronary revascularization has little effect on left ventricular function at rest, the ejection fraction during exercise and exercise-induced wall-motion abnormalities improve in most patients who experience symptomatic improvement.
SN - 0028-4793
AD - From the Cardiology Branch, National Heart, Lung, and Blood Institute, and the Nuclear Medicine Department, Clinical Center, National Institutes of Health (address reprint requests to Dr. Kent, Head, Section on Cardiovascular Diagnosis, Cardiology Branch, Bldg. 10, Room 7B–15, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20014).
U2 - PMID: 306578.
DO - 10.1056/NEJM197806292982602
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - STEINERT, PETER
AU - YUSPA, STUART H.
T1 - Biochemical Evidence for Keratinization by Mouse Epidermal Cells in Culture.
JO - Science
JF - Science
Y1 - 1978/06/30/
VL - 200
IS - 4349
M3 - Article
SP - 1491
EP - 1493
SN - 00368075
AB - More than 70 percent of the urea-extractable proteins from mouse stratum corneum or from differentiated cells of mouse epidermis grown in culture are two proteins of molecular weight 68,000 (keratin 1) and 60,000 (keratin 2), which are present in equimolar amounts on polyacrylamide gels. These proteins are the subunits of the keratin filaments, because when isolated from stratum corneum or cells grown in culture they form native-type epidermal keratin filaments in vitro. These observations provide biochemical evidence that epidermal cells grown in culture synthesize the major differentiation products of the epidermis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460279; STEINERT, PETER 1; YUSPA, STUART H. 2; Affiliations: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20014; 2: Experimental Pathology Branch, National Cancer Institute; Issue Info: 6/30/1978, Vol. 200 Issue 4349, p1491; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ottesen, E. A.
AU - Hiatt, R. A.
AU - Cheever, A. W.
AU - Sotomayor, Z. R.
AU - Neva, F. A.
T1 - The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/07//
VL - 33
IS - 1
M3 - Article
SP - 38
EP - 47
PB - Wiley-Blackwell
SN - 00099104
AB - To characterize the development and evolution of cellular immune responsiveness in individuals infected with the parasite Schistosoma mansoni, we studied fifteen patients with acute, subacute and chronic schistosumiasis. Lymphocytes from the three acutely infected patients responded vigorously to schistosome antigens in an in vitro blastogenic assay. By contrast, cells from nine chronically infected individuals were essentially unreactive to these same antigens. Patients infected for an intermediate period of time (9 months) generated responses between those of acute and chronic patients. The diminished responsiveness of chronically infected individuals was specific for schistosome antigens and did not extend to humoral immune responses. Following treatment of the infection with niridazole, these patients temporarily regained responsiveness to schistosome antigens. From these data we speculate that during the course of this parasitic helminth infection there develops a progressive and specific modulation of antigen recognition and proliferation by lymphotcytes to schistosome antigens, and that such diminished immune reactivity may be important in maintaining the unique biological relationship which exists between a host and its parasites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHISTOSOMA mansoni
KW - IMMUNE response
KW - ANTIGENS
KW - LYMPHOCYTES
KW - PARASITES
KW - IMMUNOGLOBULINS
N1 - Accession Number: 16278326; Ottesen, E. A. 1 Hiatt, R. A. 2 Cheever, A. W. 1 Sotomayor, Z. R. 3 Neva, F. A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA. 2: San Juan Laboratory Center for Disease Control, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. 3: Department of Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.; Source Info: Jul1978, Vol. 33 Issue 1, p38; Subject Term: SCHISTOSOMA mansoni; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: PARASITES; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kern, M.
T1 - Differentiation of lymphoid cells: Evidence for a B-cell specific serum suppressor.
JO - Immunology
JF - Immunology
Y1 - 1978/07//
VL - 35
IS - 1
M3 - Article
SP - 57
EP - 61
PB - Wiley-Blackwell
SN - 00192805
AB - The induction of immunoglobulin production by rabbit spleen cells is markedly inhibited by the presence of normal rabbit serum during cell culture. A similar inhibition is observed when spleen cell populations in which T cells have been inactivated are temporarily incubated with normal rabbit serum before being reconstituted with T cells by adding thymocytes. In contrast, no inhibition was observed upon temporary incubation of thymocytes with normal serum prior to addition of T cell-inactivated spleen cell populations. Removal of adherent cells did not affect the induction of immunoglobulin production or its inhibition by normal serum. Lipopolysaccharide-enhanced immunoglobulin production was also inhibited by normal serum, thereby providing additional confidence that bone-marrow derived (B) cells are the target of the normal serum inhibitor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - BLOOD plasma
KW - SERUM
KW - LYMPHOCYTES
KW - T cells
KW - CYTOLOGY
KW - CELL proliferation
KW - CELL culture
N1 - Accession Number: 13948313; Kern, M. 1; Affiliation: 1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.; Source Info: Jul78, Vol. 35 Issue 1, p57; Subject Term: LYMPHOID tissue; Subject Term: BLOOD plasma; Subject Term: SERUM; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: CYTOLOGY; Subject Term: CELL proliferation; Subject Term: CELL culture; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, Edward F.
AU - Murphy, Dennis L.
AU - Goodwin, Frederick K.
T1 - PRIMARY AFFECTIVE DISORDER: ANXIETY IN TJNIPOLAR AND BIPOLAR DEPRESSED GROUPS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1978/07//
VL - 34
IS - 3
M3 - Article
SP - 621
EP - 623
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article focuses on anxiety in unipolar and bipolar depressed groups. Current research with the Minnesota Multiphasic Personality Inventory shows that the unipolar group reports more symptoms of depression and related psychopathology than the bipolar depressed group. The 29 bipolar and 21 unipolar patients studied were all severely depressed at the time of hospitalization at the Clinical Center, National Institute of Mental Health, Bethesda, Maryland. Diagnoses were made on the basis of psychiatric interviews with patients and their immediate family, as well as reports from other hospitals.
KW - MENTAL depression
KW - BIPOLAR disorder
KW - MINNESOTA Multiphasic Personality Inventory
KW - AFFECTIVE disorders
KW - PERSONALITY tests
KW - MARYLAND
N1 - Accession Number: 15858012; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Goodwin, Frederick K. 2; Affiliation: 1: National Institute of Mental Health, Washington, D. C. 2: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jul1978, Vol. 34 Issue 3, p621; Subject Term: MENTAL depression; Subject Term: BIPOLAR disorder; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: AFFECTIVE disorders; Subject Term: PERSONALITY tests; Subject Term: MARYLAND; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kleinman, Hynda K.
AU - Murray, J. Clifford
AU - Mcgoodwin, Ermona B.
AU - Martin, George R.
T1 - Connective Tissue Structure: Cell Binding To Collagen.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/07//
VL - 71
IS - 1
M3 - Article
SP - 9
EP - 11
SN - 0022202X
AB - Established lines of fibroblasts have been shown to adhere to collagen substrates via a serum-derived glycoprotein. The attachment of various other cells to collagen types I-IV is examined here. Cells such as human skin fibroblasts, periosteum, hepatocytes, connective tissue cells, and monocytes required the serum glycoprotein and adhered equally well to all collagens, but attachment of chondrocytes, epidermal cells, and neutrophils was inhibited by the serum glycoprotein. Attachment of 2 tumorigenic cells, an osteosarcoma and a fibrosarcoma, was found to be unaffected by the serum glycoprotein. In addition, the fibrosarcoma and epidermal cells attached preferentially to type IV (basement membrane) collagen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - CONNECTIVE tissue cells
KW - COLLAGEN
KW - SERUM
KW - GLYCOPROTEINS
KW - LIVER cells
KW - CARTILAGE cells
N1 - Accession Number: 12543641; Kleinman, Hynda K. 1 Murray, J. Clifford 1 Mcgoodwin, Ermona B. 1 Martin, George R. 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p9; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: COLLAGEN; Subject Term: SERUM; Subject Term: GLYCOPROTEINS; Subject Term: LIVER cells; Subject Term: CARTILAGE cells; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543641
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stingl, Georg
AU - Katz, Stephen I.
AU - Shevach, Ethan M.
AU - Rosenthal, Alan S.
AU - Green, Ira
T1 - Analogous Functions of Macrophages and Langerhans Cells in the Initiation of the Immune Response.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/07//
VL - 71
IS - 1
M3 - Article
SP - 59
EP - 64
SN - 0022202X
AB - Langerhans cells constitute a minor cell population within the mammalian epidermis. This paper defines these cells immunologically and functionally and supports the concept that Langerhans cells are closely related to cells from the monocyte-macrophage-histiocyte series. Both cell types bear surface receptors for Fc-IgG and C3 and express surface glycoproteins, termed Ia antigens, encoded for by immune-response genes (Ir genes) of the major histocompatibility complex of the species. The expression of Ia antigens by Langerhans cells and macrophages is intimately associated with important functions of both cell types, including the capacity to present immunologically relevant antigen to the T lymphocyte and to cause proliferation to allogeneic T lymphocytes in mixed leukocyte reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - MACROPHAGES
KW - CELL populations
KW - IMMUNE response
KW - EPIDERMIS
KW - CELL receptors
N1 - Accession Number: 12544055; Stingl, Georg 1 Katz, Stephen I. 1 Shevach, Ethan M. 1 Rosenthal, Alan S. 1 Green, Ira 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, the Laboratory of Immunology and the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p59; Subject Term: LANGERHANS cells; Subject Term: MACROPHAGES; Subject Term: CELL populations; Subject Term: IMMUNE response; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12544055
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12544055&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katz, Stephen I.
T1 - Recruitment of Basophils in Delayed Hypersensitivity Reactions.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/07//
VL - 71
IS - 1
M3 - Article
SP - 70
EP - 75
SN - 0022202X
AB - Basophilic leukocytes constitute a significant proportion of the cellular infiltrates in many forms of delayed-in-onset hypersensitivity reactions in human beings, guinea pigs, and other animals. In this paper, I review current information on the role of basophils in the reactions, and present similarities and differences between Jones-Mote and classic delayed hypersensitivities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BASOPHILS
KW - ALLERGY
KW - LEUCOCYTES
KW - GRANULOCYTES
KW - IMMUNOLOGIC diseases
KW - KILLER cells
N1 - Accession Number: 12544415; Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul78, Vol. 71 Issue 1, p70; Subject Term: BASOPHILS; Subject Term: ALLERGY; Subject Term: LEUCOCYTES; Subject Term: GRANULOCYTES; Subject Term: IMMUNOLOGIC diseases; Subject Term: KILLER cells; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12544415
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12544415&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Glasgow, Allen M.
AU - Kraegel, John H.
AU - Schulman, Joseph D.
T1 - Studies of the Cause and Treatment of Hyperammonemia in Females With Ornithine Transcarbamylase Deficiency.
JO - Pediatrics
JF - Pediatrics
Y1 - 1978/07//
VL - 62
IS - 1
M3 - Article
SP - 30
EP - 37
PB - American Academy of Pediatrics
SN - 00314005
AB - Assay of ornithine transcarbamylase (OTC) activity in multiple small bits of liver (approximately 5 mg) that were obtained from a single surgical biopsy in a patient with OTC deficiency revealed a 10- to 40-fold variation in enzyme activity. Similar studies with control autopsy liver specimens varied 2.5-fold at most. The greater variation in the patient with OTC deficiency probably is due to sampling of clusters of normal or abnormal hepatocytes that resulted from inactivation of either the abnormal or normal X chromosome. Enzyme activity assayed on small liver biopsy specimens may not be representative of the entire liver in female patients with OTC deficiency. The hyperammonemia in individuals heterozygous for OTC deficiency may be due in part to shunting of bloods through multiple "metabolic portosystemic shunts." Treatment of a girl who has OTC deficiency with a low-protein diet, a low-protein diet supplemented with oral essential amino acids, and a low-protein diet plus oral ketoacids of essential amino acids was compared in short-term balance studies; on a separate occasion, a low-protein diet was compared to a low-protein diet plus lactulose. The low-protein diet plus oral ketoacid supplementation resulted in the best metabolic control of the patient's disease. On the other hand, paradoxical transient hyperammonemia was observed after the intravenous administration of ketoacids to two acutely ill female patients with OTC deficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORNITHINE carbamoyltransferase deficiency
KW - X chromosome
KW - KETONIC acids
KW - LACTULOSE
KW - LIVER cells
KW - ENZYMES
KW - WOMEN -- Health
N1 - Accession Number: 32085856; Glasgow, Allen M. 1,2 Kraegel, John H. 1,2 Schulman, Joseph D. 1,2; Affiliation: 1: Department of Endocrinology and Metabolism, Children's Hospital National Medical Center 2: Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: Jul78, Vol. 62 Issue 1, p30; Subject Term: ORNITHINE carbamoyltransferase deficiency; Subject Term: X chromosome; Subject Term: KETONIC acids; Subject Term: LACTULOSE; Subject Term: LIVER cells; Subject Term: ENZYMES; Subject Term: WOMEN -- Health; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Poulsen, S.
AU - Larson, R. H.
AU - Senning, R. S.
T1 - Effect of dextranase on plaque formation and caries development in the rat.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1978/07//
VL - 86
IS - 4
M3 - Article
SP - 231
EP - 236
SN - 0029845X
AB - Plaque formation and caries development were studied in 0-M rats fed Diet 2000 and infected with S. mutans 6715 and fecal flora from older caries-active rats. Merck dextranase, Beckman dextranase or Beckman glucanase 447 were administered singly or in combination to groups of 12 rats either as an addition to the diet or as a "mouthwash" twice daily, 5 d per week. All enzymes studied were associated with significant inhibition of both plaque formation and caries development, especially on the buccal and lingual surfaces. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEXTRANASE
KW - DENTAL plaque
KW - DENTAL caries
KW - RATS
KW - DIET
KW - GLYCOSIDASES
KW - dental caries
KW - dental plaque
KW - dextranase
KW - rat
N1 - Accession Number: 13241120; Poulsen, S. 1 Larson, R. H. 1 Senning, R. S. 1; Affiliation: 1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jul1978, Vol. 86 Issue 4, p231; Subject Term: DEXTRANASE; Subject Term: DENTAL plaque; Subject Term: DENTAL caries; Subject Term: RATS; Subject Term: DIET; Subject Term: GLYCOSIDASES; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: dextranase; Author-Supplied Keyword: rat; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gordon, James S.
T1 - Group homes: alternative to institutions.
JO - Social Work
JF - Social Work
Y1 - 1978/07//
VL - 23
IS - 4
M3 - Article
SP - 300
PB - Oxford University Press / USA
SN - 00378046
AB - The article deals with a study which considered group homes as an alternative form of residential care for adolescents in the U.S. Over 100,000 adolescents are hospitalized for mental illness each year. Many of these young people could successfully grow to adulthood in a collectively run household rather than as patients in a hospital or residential treatment center. These young people had been referred for institutionalization or continued institutionalization at the time of their entry into the home, which is referred to as Frye House in this article. Frye House was opened in 1970 by the staff of a nearby house for run-away teenagers that was designed to provide long-term residential care for young people who were unable to live with their parents despite individual and family counseling. It was one of a number of projects, including a high school and a job-finding service, that were linked to the house for runaways in a collectively run youth services program. Its founders were nonprofessionals who had been active in the civil rights and antiwar movements of the 1960s. Although they did not specifically refer to the work of others, they shared the therapeutic ideals of child guidance workers who tried to identify with the child despite his behavior.
KW - SOCIAL institutions
KW - TEENAGERS -- Services for
KW - SOCIAL services
KW - PARENT & teenager
KW - THERAPEUTICS
KW - UNITED States
N1 - Accession Number: 5274514; Gordon, James S. 1; Affiliation: 1: Research Psychiatrist, Center for Studies of Child and Family Mental Health, National Institute of Mental Health, Rockville, Maryland.; Source Info: Jul78, Vol. 23 Issue 4, p300; Subject Term: SOCIAL institutions; Subject Term: TEENAGERS -- Services for; Subject Term: SOCIAL services; Subject Term: PARENT & teenager; Subject Term: THERAPEUTICS; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-43088-007
AN - 2013-43088-007
AU - Goebes, Diane D.
AU - Shore, Milton F.
T1 - Some effects of bicultural and monocultural school environments on personality development.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1978/07//
VL - 48
IS - 3
SP - 398
EP - 407
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Mental Health Study Center, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-43088-007. PMID: 677276 Partial author list: First Author & Affiliation: Goebes, Diane D.; Catholic University of America, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Classroom Behavior Modification; Personality Development; Role Taking; School Environment; Self-Concept. Minor Descriptor: Cross Cultural Differences; Human Females. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 1978.
AB - Preadolescent girls in a bicultural school, compared with those in a mono-cultural school, showed more heterocultural peer-group organization, better self-image, and greater acceptance of an unknown cultural group. These differences were not found among younger (latency-age) children in the two schools. No significant differences were found in role-taking ability between girls in the two schools, suggesting that the bicultural school environment contributes to the difference in the other personality dimensions studied. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bicultural school environment
KW - monocultural school environment
KW - self image
KW - unknown cultural group
KW - personality dimensions
KW - role taking ability
KW - 1978
KW - Classroom Behavior Modification
KW - Personality Development
KW - Role Taking
KW - School Environment
KW - Self-Concept
KW - Cross Cultural Differences
KW - Human Females
KW - 1978
DO - 10.1111/j.1939-0025.1978.tb01330.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-43088-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06396-019
AN - 2006-06396-019
AU - Smith, Jean Paul
AU - Szara, Stephen
T1 - The Lure of Grass.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1978/07//
VL - 23
IS - 7
SP - 508
EP - 509
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06396-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Smith, Jean Paul; National Institute on Drug Abuse, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Experimentation; Marijuana. Minor Descriptor: Psychopathology; Sciences. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10). Reviewed Item: Abel, Ernest L. (Ed). The Scientific Study of Marihuana=Chicago: Nelson-Hall, 1976. Pp. xviii + 299. $12.50; 1976. Page Count: 2. Issue Publication Date: Jul, 1978.
AB - Reviews the book, The Scientific Study of Marihuana by Ernest L. Abel (1976). Abel claims that this book contains a collection of the most recent findings in marihuana research. This claim is misleading from the reader's point of view since the latest papers included in the volume came out in 1972. This compilation gives a reasonably balanced picture of the status of scientific research on marihuana as of 1972. For those who are concerned about the effects of this drug, this book may be an adequate introduction to the various aspects of the known facts, and to the different approaches science takes to learn about them. For those who need to know more about trie medical or psychological consequences of the use of this drug, more recent updating on the state of the art is clearly necessary. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marihuana
KW - scientific research
KW - sciences
KW - 1978
KW - Experimentation
KW - Marijuana
KW - Psychopathology
KW - Sciences
KW - 1978
U2 - Abel, Ernest L. (Ed). (1976); The Scientific Study of Marihuana; Chicago: Nelson-Hall, 1976. Pp. xviii + 299. $12.50
DO - 10.1037/017341
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06396-019&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-43088-023
AN - 2013-43088-023
AU - Lystad, Mary
T1 - Review of The cycle of violence: Assertive, aggressive, and abusive family interaction.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1978/07//
VL - 48
IS - 3
SP - 557
EP - 559
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-43088-023. Partial author list: First Author & Affiliation: Lystad, Mary; Division of Special Mental Health Programs, National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Domestic Violence; Family Relations. Minor Descriptor: Aggressiveness; Extraversion; Social Interaction; Well Being. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Location: US. Reviewed Item: Steinrnetz, Suzanne K. The cycle of violence: Assertive, aggressive, and abusive family interaction=191 pp. $16.95. Praeger, New York; 1977. Page Count: 3. Issue Publication Date: Jul, 1978.
AB - Reviews the book, The cycle of violence: Assertive, aggressive, and abusive family interaction by Suzanne K. Steinrnetz (see record [rid]1978-27374-000[/rid]). This book reports on the incidence and nature of violent behavior among a stratified quota sample of families in New Castle County, Delaware. As an exploratory study, the work provides valuable insights into the amount of violent behavior among some suburban/urban white households, the interrelationships of family members in violent behavior. Steinmetz asserts that what is needed on the societal level is full employment, adequate social and health benefits, and less violent television programs. Steinmetz has indeed made a contribution to understanding this critical social problem. For it is within the family that our people continue to look for love and nurture and support for this and for the next generation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violence cycle
KW - assertive interaction
KW - aggressive interaction
KW - abusive family interaction
KW - health benefits
KW - 1978
KW - Domestic Violence
KW - Family Relations
KW - Aggressiveness
KW - Extraversion
KW - Social Interaction
KW - Well Being
KW - 1978
U2 - Steinrnetz, Suzanne K. (1977); The cycle of violence: Assertive, aggressive, and abusive family interaction; 191 pp. $16.95. Praeger, New York
DO - 10.1037/h0099060
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Garn, Stanley M.
AU - Shaw, Helen A.
AU - McCabe, Kinne D.
T1 - Effect of maternal smoking on weight and weight gain between pregnancies.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1978/08//
VL - 31
IS - 8
M3 - Article
SP - 1302
EP - 1303
SN - 00029165
N1 - Accession Number: 94357615; Garn, Stanley M. 1; Shaw, Helen A. 1; McCabe, Kinne D. 2; Affiliations: 1: Center for Human Growth and Development, The University of Michigan, Ann Arbor, Michigan 48109; 2: The Collaborative Perinatal Project, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: Aug1978, Vol. 31 Issue 8, p1302; Number of Pages: 2p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Berreman, Gerald D.
AU - Carroll, James D.
AU - Coser, Rose Laub
AU - Douglas, Jack D.
AU - Freidson, Eliot
AU - Gray, Bradford H.
AU - Klockars, Carl B.
AU - Lazar, Joyce Barham
AU - Liell, John T.
AU - Pattullo, E. L.
AU - Schulman, Jay
AU - Vaughan, Ted R.
AU - Sjoberg, Gideon
T1 - COMMENTS.
JO - American Sociologist
JF - American Sociologist
Y1 - 1978/08//
VL - 13
IS - 3
M3 - Article
SP - 153
EP - 172
SN - 00031232
AB - The section presents comments on articles featured in the August 1978 issue of The American Sociologist. Gerald D. Berreman claims that the ethics and responsibility in social science research are frustrating to discuss in print or in person: the issues are complex and highly contextual so that clear-cut rules-of-thumb are impossible to formulate; they are value-laden and controversial so that discussion often degenerates into preachment, accusation and defense. James D. Carroll noted that each of the articles is a useful contribution to the understanding of law, politics and administration of knowledge. From an analytical perspective, these papers fit well into conceptual frameworks suggested by such terms as "post-industrial society," "knowledge society," and the like. From a professional perspective, each of the papers addresses issues that researchers should be more familiar with, and that professional societies should have greater capacity to address on a systematic basis than is presently the case. From a legal perspective, the paper by Kathleen Bond addresses a constitutional question under the U.S. first amendment, which involves something of a paradox. Carl B. Klockars suggests a model of sociological research that begs the softening of a series of trained incapacities, which the sociological community has worked long and hard against substantial resistance to develop.
KW - SOCIAL science research
KW - SOCIOLOGICAL research
KW - LAW -- Political aspects
KW - RESEARCH
KW - SERIAL publications
N1 - Accession Number: 4946168; Berreman, Gerald D. 1 Carroll, James D. 2 Coser, Rose Laub 3 Douglas, Jack D. 4 Freidson, Eliot 5 Gray, Bradford H. 6 Klockars, Carl B. 7 Lazar, Joyce Barham 8 Liell, John T. 9 Pattullo, E. L. 10 Schulman, Jay 11 Vaughan, Ted R. 12 Sjoberg, Gideon 13; Affiliation: 1: Dept. of Anthropology, University of California, Berkeley, CA 94720 2: Maxwell School of Public Administration, Syracuse University, Syracuse, NY 13210 3: Health Science Center, State University of New York, Stony Brook, NY 11794 4: Dept. of Sociology, University of California, San Diego, La Jolla, CA 92093 5: Dept. of Sociology, New York University, New York, NY 1003 6: Institute of Medicine, National Academy of Sciences, 2101 Constitution Ave., Washington, D.C. 20418 7: Dept. of Sociology, University of Delaware, Newark, DL 19711 8: National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD 20857 9: Dept. of Sociology, Indiana University, Indianapolis, 925 W. Michigan, Indianapolis, IN 46202 10: Center for the Behavioral Sciences, William James Hall Harvard University, Cambridge, MA 02138 11: National Jury Project, 853 Broadway, rm. 2022, New York, NY 10001 12: Dept. of Sociology, Univ. of Missouri, Columbia, MO 65201 13: Dept. of Sociology, Univ. of Texas, Austin, TX 78712; Source Info: Aug78, Vol. 13 Issue 3, p153; Subject Term: SOCIAL science research; Subject Term: SOCIOLOGICAL research; Subject Term: LAW -- Political aspects; Subject Term: RESEARCH; Subject Term: SERIAL publications; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 29p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alexander, E. L.
AU - Henkart, P. A.
T1 - Human peripheral lymphocytes bearing surface immunoglobulin do not have readily detectable Fc receptors.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/08//
VL - 33
IS - 2
M3 - Article
SP - 332
EP - 339
PB - Wiley-Blackwell
SN - 00099104
AB - The question of whether human peripheral B lymphocytes have Fc receptors was examined directly by double-label immunofluorescent techniques utilizing assays for detection of Fc receptors, surface immunoglobulin, and complement receptors. Fc receptors were detected by indirect immunofluorescence after incubation with soluble antigen-antibody complexes. Complement receptors were detected by the binding of fluoresceinated bacteria coated with complement. It was demonstrated that most surface immunoglobulin-bearing, complement-receptor positive lymphocytes did not bind soluble antigen-antibody complexes. Conversely, most cells which readily bound soluble complexes did not have surface immunoglobulin or complement receptors. Therefore, most peripheral B lymphocytes do not have easily detectable Fc receptors and most Fc receptor-bearing lymphocytes do not have B cell markers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - IMMUNOGLOBULINS
KW - B cells
KW - CELL receptors
KW - MACROPHAGES
KW - IMMUNOCYTOCHEMISTRY
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 16111359; Alexander, E. L. 1 Henkart, P. A. 1; Affiliation: 1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 USA; Source Info: Aug1978, Vol. 33 Issue 2, p332; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: B cells; Subject Term: CELL receptors; Subject Term: MACROPHAGES; Subject Term: IMMUNOCYTOCHEMISTRY; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greulich, Richard C.
T1 - Prolonging life span: Present and future possibilities.
JO - Geriatrics
JF - Geriatrics
Y1 - 1978/08//
VL - 33
IS - 8
M3 - Article
SP - 88
EP - 89
SN - 0016867X
N1 - Accession Number: 17321097; Greulich, Richard C. 1; Source Information: Aug1978, Vol. 33 Issue 8, p88; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1109
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hollenbeck, Albert R.
T1 - TELEVISION VIEWING PATTERNS OF FAMILIES WITH YOUNG INFANTS.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1978/08//
VL - 105
IS - 2
M3 - Article
SP - 259
PB - Taylor & Francis Ltd
SN - 00224545
N1 - Accession Number: 5388267; Hollenbeck, Albert R. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Aug1978, Vol. 105 Issue 2, p259; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Spaner, Fred E.
AU - Sharfstein, Steven S.
AU - Taube, Carl A.
AU - Bassuk, Ellen L.
AU - Gerson, Samuel
T1 - LETTERS.
JO - Scientific American
JF - Scientific American
Y1 - 1978/08//
VL - 239
IS - 2
M3 - Letter
SP - 8
EP - 10
SN - 00368733
AB - A letter to the editor is presented in response to the article "Deinstitutionalization and Mental Health Services," by Ellen L. Bassuk and Samuel Gerson in the February 1978 issue.
KW - Letters to the editor
KW - Mental health services
N1 - Accession Number: 19789261; Spaner, Fred E. 1; Sharfstein, Steven S. 1; Taube, Carl A. 1; Bassuk, Ellen L. 2; Gerson, Samuel 3; Affiliations: 1: National Institute of Mental Health, Rockville, Md.; 2: Harvard Medical School, Boston; 3: Cambridge Hospital, Cambridge, Massachusetts; Issue Info: Aug78, Vol. 239 Issue 2, p8; Subject Term: Letters to the editor; Subject Term: Mental health services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 2p; Document Type: Letter
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DB - eih
ER -
TY - JOUR
AU - Coulter, Charles L.
T1 - Research Instrument Sharing.
JO - Science
JF - Science
Y1 - 1978/08/04/
VL - 201
IS - 4354
M3 - Article
SP - 415
EP - 420
SN - 00368075
N1 - Accession Number: 87461069; Coulter, Charles L. 1; Affiliations: 1: head of the Biological Structure Section, Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p415; Number of Pages: 6p; Document Type: Article
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ER -
TY - JOUR
AU - RAINE, CEDRIC S.
AU - TRAUGOTT, UTE
AU - STONE, SANFORD H.
T1 - Suppression of Chronic Alergic Encephalomyelitis: Relevance to Multiple Sclerosis.
JO - Science
JF - Science
Y1 - 1978/08/04/
VL - 201
IS - 4354
M3 - Article
SP - 445
EP - 448
SN - 00368075
AB - The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous sytem antigen failed to elicit exacerbations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461087; RAINE, CEDRIC S. 1; TRAUGOTT, UTE 1; STONE, SANFORD H. 2; Affiliations: 1: Departments of Pathology and Neuroscience and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461; 2: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p445; Number of Pages: 4p; Document Type: Article
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TY - JOUR
AU - ALDRICH, J. R.
AU - BLUM, M. S.
AU - HEFETZ, A.
AU - FALES, H. M.
AU - LLOYD, H. A.
AU - ROLLER, P.
T1 - Proteins in a Nonvenomous Defensive Secretion: Biosynthetic Significance.
JO - Science
JF - Science
Y1 - 1978/08/04/
VL - 201
IS - 4354
M3 - Article
SP - 452
EP - 454
SN - 00368075
AB - In common with many arthropods, the true bug, Leptoglossus phyllopus, when disturbed, emits a two-phase secretion that consists ofan organic phase and an aqueous phase. The organic phase is a mixture of highly reactive low-molecular-weight compounds, analogous to those produced by other arthropods, and is deterrent to many kinds ofpredators. The aqueous phase, heretofore ignored in most analyses of arthropod defensive secretions, contains proteins. Even though the secretion is not injected, the proteins enzymatically catalyze the derivation of the most reactive components within the impermeable cuticular storage reservoir and, thus, constitute part of the defensive system that appears to be commonly used by arthropods producing irritating chemicals. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 87461064; ALDRICH, J. R. 1; BLUM, M. S. 1; HEFETZ, A. 2; FALES, H. M. 2; LLOYD, H. A. 2; ROLLER, P. 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p452; Number of Pages: 3p; Document Type: Article
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TY - JOUR
AU - FISCHINGER, PETER J.
AU - BLEVINS, CHARLOTTE S.
AU - DUNLOP, NANCY M.
T1 - Genomic Masking of Nondefective Recombinant Murine Leukemia Virus in Moloney Virus Stocks.
JO - Science
JF - Science
Y1 - 1978/08/04/
VL - 201
IS - 4354
M3 - Article
SP - 457
EP - 459
SN - 00368075
AB - HIX virus clonedfrom Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis ofseveral virus stocks and the examination of virus progeny from individualfoci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461075; FISCHINGER, PETER J. 1; BLEVINS, CHARLOTTE S. 1; DUNLOP, NANCY M. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/4/1978, Vol. 201 Issue 4354, p457; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - CRUIKSHANK, DALE P.
AU - DELIsI, CHARLES
T1 - Human Rights: Visiting the Soviet Union.
JO - Science
JF - Science
Y1 - 1978/08/11/
VL - 201
IS - 4355
M3 - Article
SP - 482
EP - 482
SN - 00368075
N1 - Accession Number: 87437170; CRUIKSHANK, DALE P. 1; DELIsI, CHARLES 2; Affiliations: 1: Institute for Astronomy, University of Hawaii, Honolulu 96822; 2: Laboratory of Theoretical Biology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 8/11/1978, Vol. 201 Issue 4355, p482; Number of Pages: 1/2p; Document Type: Article
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ER -
TY - JOUR
AU - Rahimtula, Anver D.
AU - O'Brien, Peter J.
AU - Seifried, Harold E.
AU - Jerina, Donald M.
T1 - The Mechanism of Action of Cytochrome P-450. Occurrence of the 'NIH Shift' during Hydroperoxide-Dependent Aromatic Hydroxylations.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/08/15/
VL - 89
IS - 1
M3 - Article
SP - 133
EP - 141
PB - Wiley-Blackwell
SN - 00142956
AB - The mechanism of liver microsomal aromatic hydroxylation has been investigated by using cumene hydroperoxide as the hydroxylating agent and comparing this reaction with the NADPH-dependent reaction. The conversion of [4-³H]acetanilide to 4-hydroxyacetanilide by rat liver microsomes (or purified cytochrome P-450) in the presence of either cumene hydroperoxide or NADPH is attended by comparable 'NIH shifts'. This indicates that hydroxylation in the two systems proceeds via a common intermediate, presumably an arene oxide. The intermediacy of an arene oxide, phenanthrene-9,10-oxide, is established by incubating [3-³H]-phenanthrene with rat-liver microsomes and cumene hydroperoxide in the presence of either nonradioactive phenanthrene-9,10-oxide as a 'trap' or in the presence of cyclohexene oxide, an inhibitor of the enzyme epoxide hydrase. Incubation of phenanthrene with cumene hydroperoxide in an 18O-enriched medium has confirmed that the oxygen atom in phenanthrene-9,10-oxide is derived from the hydroperoxide and not from the medium. [ABSTRACT FROM AUTHOR]
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KW - CYTOCHROME P-450
KW - HYDROXYLATION
KW - BIOCHEMISTRY
KW - CHEMICAL reactions
KW - MONOOXYGENASES
KW - LIVER
N1 - Accession Number: 13675093; Rahimtula, Anver D. 1 O'Brien, Peter J. 1 Seifried, Harold E. 1 Jerina, Donald M. 1; Affiliation: 1: Department of Biochemistry, Memorial University of Newfoundland, St John's, and National Institutes of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda; Source Info: 8/15/78, Vol. 89 Issue 1, p133; Subject Term: CYTOCHROME P-450; Subject Term: HYDROXYLATION; Subject Term: BIOCHEMISTRY; Subject Term: CHEMICAL reactions; Subject Term: MONOOXYGENASES; Subject Term: LIVER; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GARTLAND, JR., WILLIAM J.
T1 - Recombinant DNA Research: Proposed Revised Guidelines.
JO - Science
JF - Science
Y1 - 1978/08/18/
VL - 201
IS - 4356
M3 - Article
SP - 572
EP - 572
SN - 00368075
N1 - Accession Number: 87437201; GARTLAND, JR., WILLIAM J. 1; Affiliations: 1: Office of Recombinant DNA Activities, National Institute of General Medical Sciences, Bethesda, Maryland 20014; Issue Info: 8/18/1978, Vol. 201 Issue 4356, p572; Number of Pages: 1/3p; Document Type: Article
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ER -
TY - JOUR
AU - Schall, Jos. J.
AU - Pianka, Eric R.
T1 - Geographical Trends in Numbers of Species.
JO - Science
JF - Science
Y1 - 1978/08/25/
VL - 201
IS - 4357
M3 - Article
SP - 679
EP - 686
SN - 00368075
AB - Geographic variation in the number of coexisting plant and animal species (species density) often follows repeated patterns; best known is the general increase in species richness from temperate to tropical latitudes. Here we undertake a quantitative analysis of geographic trends in species density for the terrestrial vertebrate faunas of the United States and Australia. Trends in numbers of species of amphibians, reptiles, birds, and mammals are described and are correlated with geographic variation in abiotic environmental measures. Intercontinental comparisons reveal general patterns as well as intriguing and profound differences in vertebrate distributions. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 87437231; Schall, Jos. J. 1; Pianka, Eric R. 2; Affiliations: 1: National Institutes of Health research fellow, Department of Zoology, University of California; 2: professor in the Department of Zoology, University of Texas, Austin 78712.; Issue Info: 8/25/1978, Vol. 201 Issue 4357, p679; Number of Pages: 8p; Document Type: Article
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ER -
TY - JOUR
AU - Gage, Fred H.
AU - Lieberman, Alicia F.
T1 - A Multivariate Analysis of Social Dominance in Children.
JO - Aggressive Behavior
JF - Aggressive Behavior
Y1 - 1978/09//
VL - 4
IS - 3
M3 - Article
SP - 219
EP - 229
PB - John Wiley & Sons, Inc.
SN - 0096140X
AB - The social dominance behavior of dyads of unacquainted, same-sex 3½- year-olds was observed in a familiar laboratory playroom under two conditions: A free play situation and a situation where candy was introduced. In each of the two conditions, a principal components analysis was used to explore two issues: the usefulness of the multivariate approach in devising a definition of dominance, and the cross-situational stability of the construct. In the free play session, the first principal component that emerged was consistent with a theoretical definition of dominance. This picture was disrupted by the introduction of candy in the second condition. However, a high correlation was found between the dominance hierarchies established in each situation. It was concluded that the multivariate analysis is a useful method for the study of dominance. The generalizability of social dominance across settings was discussed as a possible explanation for the high cross-situational stability. [ABSTRACT FROM AUTHOR]
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KW - DOMINANCE (Psychology)
KW - CHILD psychology
KW - PLAYROOMS
KW - PRINCIPAL components analysis
KW - MULTIVARIATE analysis
KW - SOCIAL psychology
KW - children
KW - multivariate analysis.
KW - social dominance
N1 - Accession Number: 11989308; Gage, Fred H. 1 Lieberman, Alicia F. 2; Affiliation: 1: Department of Psychology, Texas Christian University, Fort Worth (F. H. G.) 2: Mental Health Study Center, National institute of Mental Health, .Adelphi, Maryland (A.F.L.); Source Info: 1978, Vol. 4 Issue 3, p219; Subject Term: DOMINANCE (Psychology); Subject Term: CHILD psychology; Subject Term: PLAYROOMS; Subject Term: PRINCIPAL components analysis; Subject Term: MULTIVARIATE analysis; Subject Term: SOCIAL psychology; Author-Supplied Keyword: children; Author-Supplied Keyword: multivariate analysis.; Author-Supplied Keyword: social dominance; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kannel, William B.
AU - Wolf, Philip
AU - Dawber, Thomas R.
T1 - Hypertension and cardiac impairments increase stroke risk.
JO - Geriatrics
JF - Geriatrics
Y1 - 1978/09//
VL - 33
IS - 9
M3 - Article
SP - 71
EP - 83
SN - 0016867X
N1 - Accession Number: 17308587; Kannel, William B. 1; Wolf, Philip 2; Dawber, Thomas R. 3; Source Information: Sep1978, Vol. 33 Issue 9, p71; Number of Pages: 10p; Illustrations: 9 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 4738
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DB - hch
ER -
TY - JOUR
AU - Yaoita, Hideo
T1 - Identification of IgA Binding Structures in Skin of Patients with Dermatitis Herpetiformis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1978/09//
VL - 71
IS - 3
M3 - Article
SP - 213
EP - 216
SN - 0022202X
AB - Immunoelectronmicroscopic and ultrastructural identification of the structures which bind IgA in skin of patients with dermatitis herpetiformis (DH) reveals them to be, in part, a complex of fibrillar components which are covered with amorphous substances. One of the fibers has a diameter of 80-130 Å and appears to be tubular, resembling dermal microfibrillar bundles or microtubular elements of elastic fibers. The structures, at times, are associated with the dermal microfibrillar bundles and are found within an elastic fiber system which is in close proximity to the dermal-epidermal junction. Taken together, these findings suggest that the structures which bind IgA are unique to DH and might be a part of an abnormal dermal microfibrillar bundleelastic fiber system. [ABSTRACT FROM AUTHOR]
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KW - ELECTRON microscopy -- Technique
KW - DERMATITIS herpetiformis
KW - AMORPHOUS substances
KW - MICROFIBRILS
KW - MICROTUBULES
KW - SKIN -- Inflammation
N1 - Accession Number: 12547280; Yaoita, Hideo 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep78, Vol. 71 Issue 3, p213; Subject Term: ELECTRON microscopy -- Technique; Subject Term: DERMATITIS herpetiformis; Subject Term: AMORPHOUS substances; Subject Term: MICROFIBRILS; Subject Term: MICROTUBULES; Subject Term: SKIN -- Inflammation; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12547280
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schruben, Lee W.
AU - Margolin, Barry H.
T1 - Pseudorandom Number Assignment in Statistically Designed Simulation and Distribution Sampling Experiments.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1978/09//
VL - 73
IS - 363
M3 - Article
SP - 504
SN - 01621459
AB - This research investigates various strategies for assigning pseudorandom numbers to experimental points in statistically designed simulation and distribution sampling experiments. Strategies studied include the widely advocated practices of (i) employing a common set of pseudorandom numbers for all experimental points, and (ii) assigning a unique set of pseudorandom numbers to each experimental point. An alternative, based upon blocking concepts in designed experiments, is devised and shown to improve upon existing recommendations for a wide class of problems. A small simulation, a pilot study of a hospital resource allocation problem, illustrates the new strategy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - MONTE Carlo method
KW - ANALYSIS of variance
KW - TIME series analysis
KW - SIMULATION methods & models
KW - DISTRIBUTION (Probability theory)
KW - Designed experiments
KW - Distribution sampling
KW - Monte Carlo
KW - Simulation
KW - Time series analysis
KW - Variance reduction techniques.
N1 - Accession Number: 4601225; Schruben, Lee W. 1; Margolin, Barry H. 2; Affiliations: 1: Assistant Professor, Department of Operations Research, Cornell University, Ithaca, NY 14850.; 2: Mathematical Statistician, National Institute of Environmental Health Sciences, Biometry Branch, Research Triangle Park, NC 27709.; Issue Info: Sep78, Vol. 73 Issue 363, p504; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MONTE Carlo method; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: TIME series analysis; Thesaurus Term: SIMULATION methods & models; Thesaurus Term: DISTRIBUTION (Probability theory); Author-Supplied Keyword: Designed experiments; Author-Supplied Keyword: Distribution sampling; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: Simulation; Author-Supplied Keyword: Time series analysis; Author-Supplied Keyword: Variance reduction techniques.; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 17p; Document Type: Article
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DB - buh
ER -
TY - JOUR
AU - RAPP, ULF R.
AU - TODARO, GEORGE J.
T1 - Generation of New Mouse Sarcoma Viruses in Cell Culture.
JO - Science
JF - Science
Y1 - 1978/09//9/1/1978
VL - 201
IS - 4358
M3 - Article
SP - 821
EP - 824
SN - 00368075
AB - Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519399; RAPP, ULF R. 1; TODARO, GEORGE J. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/1/1978, Vol. 201 Issue 4358, p821; Number of Pages: 4p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - FOX, BERNARD H.
T1 - Cancer Death Risk in Hospitalized Mental Patients.
JO - Science
JF - Science
Y1 - 1978/09/15/
VL - 201
IS - 4360
M3 - Article
SP - 966
EP - 968
SN - 00368075
N1 - Accession Number: 87546608; FOX, BERNARD H. 1; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 9/15/1978, Vol. 201 Issue 4360, p966; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - GOLDMAN, ARNOLD I.
AU - O'BRIEN, PAUL J.
T1 - Phagocytosis in the Retinal Pigment Epithelium of the RCS Rat.
JO - Science
JF - Science
Y1 - 1978/09/15/
VL - 201
IS - 4360
M3 - Article
SP - 1023
EP - 1025
SN - 00368075
AB - The retinal pigment epithelium of RCS rats, previously thought not to phagocytize photoreceptor outer segments, exhibited a peak of phagocytosis in vivo when animals were kept under conditions of cyclic lighting (12 hours of darkness and 12 hours of light). This peak occurred at 1 hour after the onset of light, with maximum and minimum levels of phagocytosis averaging about 5 percent of that found in the pigment epithelium of Osborn-Mendel rats used as a control. Eyecups that were obtained from Osborn-Mendel rats and maintained for up to 3 hours in organ culture demonstrated levels of phagocytosis that were sevenfold greater than those of unincubated controls. Likewise, a tenfold increase occurred in incubated as opposed to unincubated RCS eyes, raising the possibility that phagocytosis could be experimentally stimulated in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546610; GOLDMAN, ARNOLD I. 1; O'BRIEN, PAUL J. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 9/15/1978, Vol. 201 Issue 4360, p1023; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - AGUIRRE, G.
AU - FARBER, D.
AU - LOLLEY, R.
AU - FLETCHER, R. T.
AU - CHADER, G. J.
T1 - Rod-Cone Dysplasia in Irish Setters: A Defect in Cyclic GMP Metabolism in Visual Cells.
JO - Science
JF - Science
Y1 - 1978/09/22/
VL - 201
IS - 4361
M3 - Article
SP - 1133
EP - 1134
SN - 00368075
AB - An abnormality in retinal guanosine 3',5'-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasia of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546634; AGUIRRE, G. 1; FARBER, D. 2; LOLLEY, R. 3; FLETCHER, R. T. 4; CHADER, G. J. 4; Affiliations: 1: Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104; 2: Jules Stein Eye Institute, School of Medicine, University of California, Los Angeles 90024; 3: Developmental Neurology, Veterans Administration Hospital, Sepulveda, California 91343; 4: National Eye Institute, Bethesda, Maryland 20014; Issue Info: 9/22/1978, Vol. 201 Issue 4361, p1133; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rogot, Eugene
T1 - Smoking and Life Expectancy among U.S. Veterans.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1978/10//
VL - 68
IS - 10
M3 - Article
SP - 1023
PB - American Public Health Association
SN - 00900036
AB - The article discusses on medical study concerning smoking and life expectancy between veterans in the U.S. Life expectancies were estimated for selected groups of smokers, ex-smokers, and non-smokers. The researcher assessed that life expectancy varied based on the number of cigarettes smoked per day. The most notable differences in life expectancy were among non-smokers and heavy-cigarette smokers. These differences were the most superior at the younger ages, ranging 9 years at ages 35 and 40. Life expectancies for cigarette smokers differed directly with age began smoking. In general range of ages, differences in life expectancy among non-smokers and ex-cigarette smokers who stopped for other than doctor's orders were less than those between non-smokers and current cigarette smokers.
KW - LIFE expectancy
KW - VETERANS -- Health
KW - CIGARETTE smokers
KW - MEDICAL research
KW - TOBACCO -- Physiological effect
KW - MORTALITY
KW - CLINICAL medicine
KW - CASE studies
KW - UNITED States
N1 - Accession Number: 5669492; Rogot, Eugene 1; Affiliation: 1: Epidemiology Branch, Division of Heat and Vascular Diseases, National Heart, Lung, and Blood Institute, Federal building, Room 2C08, Bethesda, MD 20014; Source Info: Oct78, Vol. 68 Issue 10, p1023; Subject Term: LIFE expectancy; Subject Term: VETERANS -- Health; Subject Term: CIGARETTE smokers; Subject Term: MEDICAL research; Subject Term: TOBACCO -- Physiological effect; Subject Term: MORTALITY; Subject Term: CLINICAL medicine; Subject Term: CASE studies; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Sitaram, N.;
AU - Moore, A. M.;
AU - Gillin, J. C.;
T1 - Effect of physostigmine on normal human sleep and dreaming
CT - Effect of physostigmine on normal human sleep and dreaming
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1978/10/01/
VL - 35
IS - Oct
SP - 1239
EP - 1243
AD - National Institute of Mental Health, Unit on Sleep Studies, BPB, Bldg. 10, Rm. 3N224, Bethesda, MD 20014; and St. Elizabeth's Hospital, Washington, D.C.
N1 - Accession Number: 16-4113; Language: English; Trade Name: Antilirium; Generic Name: Physostigmine; Chemical Name: Physostigmine--57-47-6; Therapeutic Class: (12:04); AHFS Class: Parasympathomimetic agents physostigmine; References: 23; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata
N2 - In a study with 17 paid normal volunteers between 20 and 38-yr-old, an IV infusion of either placebo or physostigmine (Antilirium; I), 0.5 mg/night was administered to determine the effects of I on sleep and dreaming. It was shown that dreaming occurred during I induced rapid eye movement sleep, but it did not alter mentation during non-rapid eye movement sleep. The dreams were similar to spontaneous rapid eye movement sleep dreams in content, vividness, unusualness and emotionality. As an anticholinesterase, the drug increases the action of brain acetylcholine and induces rapid eye movement sleep in normal humans.
KW - Physostigmine--effects-;
KW - Parasympathomimetic agents--physostigmine--effects, sleep, dreaming, IV, patients;
KW - Mechanism of action--physostigmine--effects, sleep, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Klempner, M. S.
AU - Gallin, J. I.
T1 - Inhibition of neutrophil Fc receptor function by corticosteroids.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/10//
VL - 34
IS - 1
M3 - Article
SP - 137
EP - 142
PB - Wiley-Blackwell
SN - 00099104
AB - The ability of hydrocortisone sodium succinate to inhibit the adherence of IgG-sensitized erythrocytes (EA) to human peripheral blood neutrophil monolayers is described. The steroid inhibitory effect was dose-dependent with a 32.4±2.4% decrease in EA binding at 2 × 10-4 M. There was no difference between the addition of hydrocortisone prior to or at the same time as EA and steroid interference with EA binding was completely reversible. In addition, hydrocortisone was unable to displace bound EA. These findings suggest that hydrocortisone interferes with the availability of the neutrophil Fc receptor for binding and provides further insight into the host factors which are compromised during corticosteroid administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROCORTISONE
KW - CELL receptors
KW - ADRENOCORTICAL hormones
KW - IMMUNOGLOBULIN G
KW - IMMUNOGLOBULINS
KW - MONOMOLECULAR films
N1 - Accession Number: 16253353; Klempner, M. S. 1 Gallin, J. I. 1; Affiliation: 1: The Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Oct1978, Vol. 34 Issue 1, p137; Subject Term: HYDROCORTISONE; Subject Term: CELL receptors; Subject Term: ADRENOCORTICAL hormones; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOGLOBULINS; Subject Term: MONOMOLECULAR films; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoover, Carol F.
T1 - DIFFERENTIATING SCHIZOPHRENICS THROUGH PARENTAL CONFLICT.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1978/10//
VL - 34
IS - 4
M3 - Article
SP - 844
EP - 849
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article examines the difference between young schizophrenics' conflict with parents and the marital conflict experienced by other parent couples. The study was performed by comparing 154 parents of schizophrenic, maladjusted, and community young people by using the Conflict in Marriage Scale (CIMS), an agree-disagree card sort. The test was administered twice, at intervals of a week, in order to establish reliability. Views of children were not measured in the CIMS. When the entire sample was entered together into the discriminant analysis, six identifying formulae were elicited, one for each of the diagnostic-sex groups. No indication were obtained from results that parental dissension has a role per se in producing schizophrenia, although disturbed marriages seemed to be associated with disturbed adolescents.
KW - SCHIZOPHRENICS
KW - MENTALLY ill
KW - SCHIZOTYPAL personality disorder
KW - PROBLEM youth
KW - MARITAL conflict
KW - DISCRIMINANT analysis
KW - MULTIVARIATE analysis
KW - PSYCHOMETRICS
N1 - Accession Number: 15866784; Hoover, Carol F. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Oct1978, Vol. 34 Issue 4, p844; Subject Term: SCHIZOPHRENICS; Subject Term: MENTALLY ill; Subject Term: SCHIZOTYPAL personality disorder; Subject Term: PROBLEM youth; Subject Term: MARITAL conflict; Subject Term: DISCRIMINANT analysis; Subject Term: MULTIVARIATE analysis; Subject Term: PSYCHOMETRICS; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seidman, J. G.
AU - Leder, Aya
AU - Nau, Marion
AU - Norman, Barbara
AU - Leder, Philip
T1 - Antibody Diversity.
JO - Science
JF - Science
Y1 - 1978/10/06/
VL - 202
IS - 4363
M3 - Article
SP - 11
EP - 17
SN - 00368075
AB - Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin- producing and uncommitted (embryonic) cells, thereby establishing -the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546694; Seidman, J. G. 1; Leder, Aya 1; Nau, Marion 1; Norman, Barbara 1; Leder, Philip 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014; Issue Info: 10/6/1978, Vol. 202 Issue 4363, p11; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHULTZ, RICHARD M.
AU - PAVLIDIS, NICHOLAS A.
AU - STYLOS, WILLIAM A.
AU - CHIRISOS, MICHAEL A.
T1 - Regulation of Macrophage Tumoricidal Function: A Role for Prostaglandins of the E Series.
JO - Science
JF - Science
Y1 - 1978/10/20/
VL - 202
IS - 4365
M3 - Article
SP - 320
EP - 321
SN - 00368075
AB - Exogenously added prostaglandins E1 and E2, but not F2α, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3 ',5 '-monophosphate (cyclic AMP) in modulating macrophagefunctional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85233214; SCHULTZ, RICHARD M. 1; PAVLIDIS, NICHOLAS A. 1; STYLOS, WILLIAM A. 1; CHIRISOS, MICHAEL A. 1; Affiliations: 1: Laboratory of RNA Tumor Viruses, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 10/20/1978, Vol. 202 Issue 4365, p320; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYLER, DAVID J.
AU - WAHL, SHARON M.
AU - WAHL, LARRY M.
T1 - Hepatic Fibrosis in Schistosomiasis: Egg Granulomas Secrete Fibroblast Stimulating Factor in vitro.
JO - Science
JF - Science
Y1 - 1978/10/27/
VL - 202
IS - 4366
M3 - Article
SP - 438
EP - 440
SN - 00368075
AB - Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218617; WYLER, DAVID J. 1; WAHL, SHARON M. 2; WAHL, LARRY M. 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Microbiology and Immunology, National Institute of Dental Research; Issue Info: 10/27/1978, Vol. 202 Issue 4366, p438; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Baker, J. J.
AU - Wright, W. E.
AU - Chan, S. P.
AU - Oppenheim, J. J.
T1 - Longitudinal effects of clinical therapy and the edentulous state on the transformation of lymphocytes from patients with severe periodontitis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/11//
VL - 34
IS - 2
M3 - Abstract
SP - 199
EP - 205
PB - Wiley-Blackwell
SN - 00099104
AB - Twenty dentulous subjects undergoing clinical therapy for severe periodontitis were used to determine the longitudinal effects of bacterial plaque reduction on in vitro lymphocyte transformation. The therapy consisted of either complete extractions or partial extractions and periodontal surgery combined with rigorous oral hygiene. Prior to therapy lymphocytes from these subjects responded significantly to Streptolysin O (SLO) but were not transformed significantly by solubilized dental plaque. However, after therapy lymphocytes from these same subjects responded significantly to both solubilized dental plaque and SLO. This indicates that the severe periodontitis patients were specifically unresponsive to solubilized dental plaque prior to therapy. The mechanism of the unresponsiveness is not clear, but probably does not involve serum factors because supplementation of the lymphocyte cultures with pooled homologous plasma from individuals with gingivitis or moderate periodontitis (instead of the patient's autologous plasma) did not significantly change the mean lymphocyte responses to solubilized dental plaque. In addition, lymphocytes from eleven long-term (5-18 yr) edentulous subjects, who were free of oral inflammation, were significantly transformed by solubilized dental plaque. The latter lymphocyte responses and those of the treated periodontitis patients could be due either to the presence of low levels of oral bacteria in the edentulous mouth or to the lymphocyte transformation assay being a measure of previous antigen sensitization rather than current disease status. In either case, lymphocyte transformation to solubilized dental plaque is not a useful diagnostic tool in periodontitis, but should continue to be a valuable research tool for investigating pathological mechanisms in periodontitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTITIS
KW - INFLAMMATION
KW - LYMPHOCYTES
KW - DENTAL plaque
KW - THERAPEUTICS
KW - EDENTULOUS mouth
N1 - Accession Number: 16434982; Baker, J. J. 1 Wright, W. E. 2 Chan, S. P. 1 Oppenheim, J. J. 3; Affiliation: 1: Department of Immunology Litton Bionetics, Kensington, Maryland, U.S.A. 2: Clinical Dental Services Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A. 3: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov1978, Vol. 34 Issue 2, p199; Subject Term: PERIODONTITIS; Subject Term: INFLAMMATION; Subject Term: LYMPHOCYTES; Subject Term: DENTAL plaque; Subject Term: THERAPEUTICS; Subject Term: EDENTULOUS mouth; Number of Pages: 7p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fauci, A. S.
AU - Pratt, Karen R.
AU - Whalen, Gail
T1 - Activation of human B lymphocytes. VIII. DIFFERENTIAL RADIOSENSITIVITY OF SUBPOPULATIONS OF LYMPHOID CELLS INVOLVED IN THE POLYCLONALLY-INDUCED PFC RESPONSES OF PERIPHERAL BLOOD B LYMPHOCYTES.
JO - Immunology
JF - Immunology
Y1 - 1978/11//
VL - 35
IS - 5
M3 - Article
SP - 715
EP - 720
PB - Wiley-Blackwell
SN - 00192805
AB - The differential effect of various doses of irradiation on subpopulations of human peripheral blood lymphoid cells involved in the pokeweed mitogen (PWM) induced PFC response against sheep red blood cells (SRBC) was studied. The plaque forming B cells were quite sensitive to low doses of irradiation with complete suppression of responses at 300 to 500 rad. On the contrary, helper T-cell function was resistant to 2000 rad. Co-culture of irradiated T cells with autologous or allogeneic B cells resulted in marked enhancement of PFC responses consistent with the suppression of naturally occurring suppressor cells with a resulting pure helper effect. Irradiated T-cell-depleted suspensions failed to produce this effect as did heat killed T cells, whereas mitomycin C treated T cells gave effects similar to irradiated T cells. These findings are consistent with a lack of requirement of cell division for a T-cell helper effect and a requirement of mitosis or another irradiation sensitive, mitomycin C sensitive process for a T-suppressor cell effect. These studies have potential relevance in the evaluation of subpopulations of human lymphoid cells involved in antibody production in normal individuals and in disease states. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - IRRADIATION
KW - LYMPHOCYTES
KW - CELL proliferation
KW - ANTIGEN presenting cells
KW - BLOOD cells
KW - IMMUNOSUPPRESSIVE agents
KW - IMMUNOLOGY
N1 - Accession Number: 13954308; Fauci, A. S. 1 Pratt, Karen R. 1 Whalen, Gail 1; Affiliation: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Nov78, Vol. 35 Issue 5, p715; Subject Term: B cells; Subject Term: IRRADIATION; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Subject Term: ANTIGEN presenting cells; Subject Term: BLOOD cells; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hooks, John J.
T1 - Possibility of a viral etiology in recurrent aphthous ulcers and Behcet's syndrome.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1978/11//
VL - 7
IS - 6
M3 - Article
SP - 353
EP - 364
SN - 03009777
AB - The clinical signs, laboratory data, and histological features of recurrent aphthous ulcers (RAU) and Behçet's syndrome suggest a viral etiology. In fact, there are reports of adenovirus isolations in herpetiform oral ulcers and on the isolation of a filterable agent in sporadic cases of Behçet's syndrome. However, isolation studies on the major and minor aphthous ulcers and more recent studies on Behçet's syndrome have been negative. A review of the literature on the role of viruses and autoimmunity in RAU and Behçet's syndrome is presented. Biopsy specimens of ulcerative lesions were grown in vitro for up to 300 days. Those cultures, along with leukocytes and body fluids, were examined by a variety of techniques for the presence of virus or viral antigens. Although a persistent or latent virus was not detected, these negative studies cannot elude a viral etiology. In fact, the hypothesis of an infectious and viral etiology is still reasonable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES -- Causes & theories of causation
KW - FOOT & mouth disease
KW - BEHCET'S disease
KW - ORAL diseases
KW - BIOPSY
KW - SYMPTOMS
N1 - Accession Number: 14875649; Hooks, John J. 1; Affiliation: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p353; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FOOT & mouth disease; Subject Term: BEHCET'S disease; Subject Term: ORAL diseases; Subject Term: BIOPSY; Subject Term: SYMPTOMS; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1600-0714.ep14875649
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graykowski, Edward A.
AU - Kingman, Albert
T1 - Double-blind trial of tetracycline in recurrent aphthous ulceration.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1978/11//
VL - 7
IS - 6
M3 - Article
SP - 376
EP - 382
SN - 03009777
AB - A double-blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical-systemic treatment procedure was used. Both the placebo and tetracycline groups experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracycline treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on placebo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACYCLINE
KW - PAIN
KW - FOOT & mouth disease
KW - ULCERS
KW - PLACEBOS (Medicine)
KW - THERAPEUTICS
N1 - Accession Number: 14875661; Graykowski, Edward A. 1 Kingman, Albert 1; Affiliation: 1: Laboratory of Oral Medicine and National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p376; Subject Term: TETRACYCLINE; Subject Term: PAIN; Subject Term: FOOT & mouth disease; Subject Term: ULCERS; Subject Term: PLACEBOS (Medicine); Subject Term: THERAPEUTICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0714.ep14875661
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Benezra, David
AU - Nussenblatt, Robert
T1 - Ocular manifestations of Behcet's disease.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1978/11//
VL - 7
IS - 6
M3 - Article
SP - 431
EP - 435
SN - 03009777
AB - The manifestations, possible etiological factors and therapeutical modalities of ocular Behçet are outlined. The major ocular findings involve both the anterior and posterior uvea. The vasculitis retinae, the periphlebitis and the pipe stem sheathing along with the recurrent vitreous hemorrhages lead to the visual impairment. Exacerbation and remission of the ocular inflammatory processes are characteristic. However, the impairment of visual function occurring after each attack is generally irreversible. The effectiveness of the present modalities of treatment is uncertain. Chlorambucil® in doses of 6-8 mg daily appears to have an outstanding beneficial effect. However, carefully monitored control studies are lacking and should be conducted before any unequivocal conclusions can he reached. It appears to us that the etiology-pathology of Behçet's disease might be a sequence of events triggered by an interaction between a virus and specific receptors on the host cell membrane (HLA determined?). This initial interaction is followed by a malregulation of the host immune mechanism Leading to autoinmmune phenomena which are characteristics of the disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCULAR manifestations of general diseases
KW - BEHCET'S disease
KW - SYMPTOMS
KW - POSTERIOR uveitis
KW - DISEASES -- Causes & theories of causation
KW - CELL membranes
N1 - Accession Number: 14875674; Benezra, David 1 Nussenblatt, Robert 1; Affiliation: 1: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: 1978, Vol. 7 Issue 6, p431; Subject Term: OCULAR manifestations of general diseases; Subject Term: BEHCET'S disease; Subject Term: SYMPTOMS; Subject Term: POSTERIOR uveitis; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: CELL membranes; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1600-0714.ep14875674
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sostek, Andrew J.
T1 - Effects of Electrodermal Lability and Payoff Instructions on Vigilance Performance.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1978/11//
VL - 15
IS - 6
M3 - Article
SP - 561
EP - 568
SN - 00485772
AB - The psychophysiologically based personality dimension of electrodermal lability has been related to vigilance performance. The present study investigated this effect basing lability on spontaneous electrodermal fluctuations and habituation of the electrodermal orienting response, and attempted to modify performance using monetary payoffs. In an auditory vigilance task, detections and sensitivity (d') declined across blocks, and payoffs influenced detections, commission errors, d', and response bias in the expected directions. Although there were no main effects for spontaneous lability, habituation labiles had higher log false alarm rates, lower response bias and tended to detect more signals. Using either lability criterion, labiles did not demonstrate a vigilance decrement and were more responsive than stabiles to payoff instructions. Lability based on habituation rate was therefore more clearly related to vigilance performance than lability based on spontaneous fluctuations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HABITUATION (Neuropsychology)
KW - GALVANIC skin response
KW - INTROVERSION
KW - EXTRAVERSION
KW - SENSATION seeking
KW - Electrodermal lability
KW - Habituation sensitivity
KW - Introversion-extraversion
KW - Response bias
KW - Sensation seeking.
KW - Vigilance
N1 - Accession Number: 11189463; Sostek, Andrew J. 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Nov1978, Vol. 15 Issue 6, p561; Subject Term: HABITUATION (Neuropsychology); Subject Term: GALVANIC skin response; Subject Term: INTROVERSION; Subject Term: EXTRAVERSION; Subject Term: SENSATION seeking; Author-Supplied Keyword: Electrodermal lability; Author-Supplied Keyword: Habituation sensitivity; Author-Supplied Keyword: Introversion-extraversion; Author-Supplied Keyword: Response bias; Author-Supplied Keyword: Sensation seeking.; Author-Supplied Keyword: Vigilance; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-8986.ep11189463
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guenthner, Thomas M.
AU - Nebert, Daniel W.
T1 - Evidence in Rat and Mouse Liver for Temporal Control of Two Forms of Cytochrome P-450 Inducible by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/11/15/
VL - 91
IS - 2
M3 - Article
SP - 449
EP - 456
PB - Wiley-Blackwell
SN - 00142956
AB - In the liver of perinatal rats or mice, the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon hydroxylase to total cytochrome P-450 content decreases, whereas the ratio of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced acetanilide 4-hydroxylase to total cytochrome P-450 content increases, between 18 or 19 days and 22 days following conception. The ontogenesis of inducible aryl hydrocarbon hydroxylase corresponds well with increases in a 56000-Mr electrophoretic band; we suggest this band represents the cytochrome P1-450 subunit. The later temporal expression of inducible acetanilide 4-hydroxylase closely parallels 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced increases in size of a 54000-Mr electrophoretic band and a 2–3-nm hypsochromic shift in the Soret peak of the total microsomal reduced cytochrome P450 · CO complex. We suggest this band represents the cytochrome P-448 subunit. Previous work from this laboratory has shown that this developmental difference is separated by several weeks in rabbit liver, as compared with several day's separation shown in this report with rat or mouse liver. The data here therefore provide evidence in the rodent for temporal control of the expression of different structural gene products regulated by the Ah locus. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACHLORODIBENZODIOXIN
KW - HYDROCARBONS
KW - CYTOCHROME P-450
KW - MICROSOMES
KW - PROTEIN synthesis
KW - GENETIC regulation
N1 - Accession Number: 13696496; Guenthner, Thomas M. 1 Nebert, Daniel W. 1; Affiliation: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: 11/15/78, Vol. 91 Issue 2, p449; Subject Term: TETRACHLORODIBENZODIOXIN; Subject Term: HYDROCARBONS; Subject Term: CYTOCHROME P-450; Subject Term: MICROSOMES; Subject Term: PROTEIN synthesis; Subject Term: GENETIC regulation; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hasilik, Andrej
AU - Tanner, Widmar
T1 - Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/11/15/
VL - 91
IS - 2
M3 - Article
SP - 567
EP - 575
PB - Wiley-Blackwell
SN - 00142956
AB - Carboxypeptidase Y purified from bakers yeast, Mr 61000, contains 2.7% glucosamine and 14.1% mannose, which correspond to 8 and 53 residues/molecule respectively. By digesting the enzyme with a mixture of proteinases glycopeptides are released containing aspartic acid/asparagine, glucosamine and mannose in a ratio of 1.5:2:13. Oligosaccharides obtained after hydrazinolysis are composed of glucosamine and mannose. Four asparagine-linked oligosaccharides of the general formula (GlcNAc)2(Man)13 are proposed to be present in carboxypeptidase Y. Similar antigenicity and immunoreactivity properties of the enzyme and of cell wall mannan indicate a close structural relationship of their sugar moieties. The enzyme synthesized in the presence of tunicamycin has a molecular weight of about 51000,just as expected if devoid of sugar. Tunicamycin also reduces specifically the amount of the carbohydrate-free protein present in the cells. Since this product is metabolically stable, the reduced amount must be due to an inhibited rate of biosynthesis. This indicates a regulatory link between the glycosylation of the protein moiety and its biosynthesis. Like the normal carboxypeptidase Y also the carbohydrate-free form is synthesized via a larger precursor. The processing of the precursor in vivo and in vitro is not affected by the absence of its carbohydrate portion. The size of the enzyme formed in the presence of 2-deoxyglucose is reduced too, although to a lesser extent. A glucosamine auxotroph, if starved for glucosamine, synthesizes in part a carboxypeptidase Y species analogous to that found in the cells poisoned by tunicamycin. Isolation of carboxypeptidase Y from the starved mutant cells is described. Experiments on glycosylation of such carboxypeptidase h7 vitro (also after its denaturation) have been negative, however. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBOXYPEPTIDASES
KW - GLUCOSAMINE
KW - MANNOSE
KW - BIOSYNTHESIS
KW - ASPARAGINE
KW - OLIGOSACCHARIDES
KW - TUNICAMYCIN
N1 - Accession Number: 13697461; Hasilik, Andrej 1,2 Tanner, Widmar 1; Affiliation: 1: Fachbereich Biologie und Vorkklinische Medizin der Universität Regensburg 2: National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, U.S.A.; Source Info: 11/15/78, Vol. 91 Issue 2, p567; Subject Term: CARBOXYPEPTIDASES; Subject Term: GLUCOSAMINE; Subject Term: MANNOSE; Subject Term: BIOSYNTHESIS; Subject Term: ASPARAGINE; Subject Term: OLIGOSACCHARIDES; Subject Term: TUNICAMYCIN; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KRAMER, MORTON
AU - GRUENBERG, ERNEST M.
AU - GORI, GIO B.
AU - RICHTER, BRIAN J.
T1 - Prevention of Long-Term and Disabling Diseases.
JO - Science
JF - Science
Y1 - 1978/11/17/
VL - 202
IS - 4369
M3 - Article
SP - 697
EP - 698
SN - 00368075
N1 - Accession Number: 85268563; KRAMER, MORTON 1; GRUENBERG, ERNEST M. 1; GORI, GIO B. 2; RICHTER, BRIAN J. 3; Affiliations: 1: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205; 2: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014; 3: Enviro Control, Inc., Rockville, Maryland 20852; Issue Info: 11/17/1978, Vol. 202 Issue 4369, p697; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOLDMAN, PATRICIA S.
T1 - Neuronal Plasticity in Primate Telencephalon: Anomalous Projections Induced by Prenatal Removal of Frontal Cortex.
JO - Science
JF - Science
Y1 - 1978/11/17/
VL - 202
IS - 4369
M3 - Article
SP - 768
EP - 770
SN - 00368075
AB - When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268598; GOLDMAN, PATRICIA S. 1; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 11/17/1978, Vol. 202 Issue 4369, p768; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PAUL, STEVEN M.
AU - SKOLNICK, PHIL
T1 - Rapid Changes in Brain Benzodiazepine Receptors After Experimental Seizures.
JO - Science
JF - Science
Y1 - 1978/11/24/
VL - 202
IS - 4370
M3 - Article
SP - 892
EP - 894
SN - 00368075
AB - Seizures induced in the rat by electroshock or by injections of pentylenetetrazol increase the specific binding of diazepam to putative receptor sites in cerebral cortical membranes. The enhancement of diazepam binding results from a rapid increase in the number of available binding sites rather than a change in receptor affinity. The postictal increase in cortical benzodiazepine receptors suggests that the cerebral cortex might be more sensitive to the anticonvulsant effects of the benzodiazepines after seizures. This observation may be related to the mechanism of action of these drugs in the treatment of recurrent seizures such as status epilepticus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268635; PAUL, STEVEN M. 1; SKOLNICK, PHIL 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Biopsychosocial Research, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857; Issue Info: 11/24/1978, Vol. 202 Issue 4370, p892; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - IUVONE, P. MICHAEL
AU - GALLI, C. L.
AU - GARRISON-GUND, C. K.
AU - NEFF, N. H.
T1 - Light Stimulates Tyrosine Hydroxylase Activity and Dopamine Synthesis in Retinal Amacrine Neurons.
JO - Science
JF - Science
Y1 - 1978/11/24/
VL - 202
IS - 4370
M3 - Article
SP - 901
EP - 902
SN - 00368075
AB - Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268639; IUVONE, P. MICHAEL 1; GALLI, C. L. 1; GARRISON-GUND, C. K. 1; NEFF, N. H. 1; Affiliations: 1: Laboratory of Preclinical Phamacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 11/24/1978, Vol. 202 Issue 4370, p901; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kirkpatrick, C. H.
AU - Greenberg, Lynn E.
AU - Chapman, S. W.
AU - Goldstein, G.
AU - Lewis, Verna M.
AU - Twomey, J. J.
T1 - Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1978/12//
VL - 34
IS - 3
M3 - Article
SP - 311
EP - 317
PB - Wiley-Blackwell
SN - 00099104
AB - To further characterize the immunological abnormalities in patients with chronic mucocutaneous candidiasis, the thymic hormone activity in their plasma was measured. Of the sixteen patients in the study, seven had chronic diffuse candidiasis, five had candidiasis with endocrinopathies and four had candidiasis with thymoma. Only one patient, an anergic child with chronic diffuse candidiasis had severe deficiency of plasma thymic hormone activity. Two patients, a woman with candidiasis and multiple endocrinopathies and an elderly man with metastatic epithelial thymoma had supranomal values. These studies indicate that the immunological deficit in most patients with these forms of chronic mucucutaneous candidiasis is not due to deficiency of a thymic inductive activity and suggest that an intrinsic defect exists in the maturation of antigen-responsive lymphoid cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANDIDIASIS
KW - THYMIC hormones
KW - BLOOD plasma
KW - LYMPHOID tissue
KW - MYCOSES
KW - THYMUS extract
N1 - Accession Number: 16616163; Kirkpatrick, C. H. 1,2,3 Greenberg, Lynn E. 1,2,3 Chapman, S. W. 1,2,3 Goldstein, G. 1,2,3 Lewis, Verna M. 1,2,3 Twomey, J. J. 1,2,3; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bathesda, Maryland, USA. 2: Ortho Pharmaceutical Corporation, Raritan, New Jersey, USA. 3: Immunohematology Research Laboratory, Veterans Administration Hospital, Houston, Texas, USA.; Source Info: Dec1978, Vol. 34 Issue 3, p311; Subject Term: CANDIDIASIS; Subject Term: THYMIC hormones; Subject Term: BLOOD plasma; Subject Term: LYMPHOID tissue; Subject Term: MYCOSES; Subject Term: THYMUS extract; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wodnar-Filipowicz, Aleksandra
AU - Szcz&ecedil;na, Elzbieta
AU - Zan-Kowalczewska, Malgorzata
AU - Muthukrishnan, Subbaratnam
AU - Szybiak, Urszula
AU - Legocki, Andrzej B.
AU - Filipowicz, Witold
T1 - 5'-Terminal 7-Methylguanosine and mRNA Function.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1978/12//12/1/78
VL - 92
IS - 1
M3 - Article
SP - 69
EP - 80
PB - Wiley-Blackwell
SN - 00142956
AB - 1. Decapped tobacco mosaic virus (TMV) RNA and rabbit globin mRNA were prepared by enzymic treatment of RNAs with nucleotide pyrophosphatase purified from potato. The extent of removal of 5'-terminal 7-methylguanosine 5'-monophosphate (m GMP) from TMV RNA was at least 97% as estimated by labeling of the 5' termini in vitro with S-adenosyl[methyl-³H]methionine catalysed by vaccinia virus methyltransferases. 2. The effect of enzymic decapping was compared with the effect of cap analogs on mRNAs translation in a nuclease-treated rabbit reticulocyte lysate and in a wheat germ extract. When translation was studied at low K+ concentration, little or no dependence on 5'-terminal 7-methylguanosine was found with either cell-free system. The importance of the 5'-terminal cap for the efficient translation of TMV RNA and globin mRNA increased as the concentration of K+ in a protein-synthesis system was raised. In a reticulocyte lysate analogs and enzymic decapping had a similar effect on translation. In a wheat germ extract, mRNA decapping resulted in a more pronounced decrease of mRNA activity, presumably due to the increased susceptibility of decapped mRNAs to the nucleases present in this protein synthesis system. 3. The requirement for a 5'-terminal cap was similar for the synthesis of 130 000-Mr and 165 000-Mr polypeptides coded by TMV RNA. This indicates that both proteins may be initiated at the common site close to the 5' terminus. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESSENGER RNA
KW - PLANT viruses
KW - GLOBIN genes
KW - NUCLEOTIDES
KW - PYROPHOSPHATES
KW - ADENOSYLMETHIONINE
N1 - Accession Number: 13698710; Wodnar-Filipowicz, Aleksandra 1,2,3 Szcz&ecedil;na, Elzbieta 1,2,3 Zan-Kowalczewska, Malgorzata 1,2,3 Muthukrishnan, Subbaratnam 1,2,3 Szybiak, Urszula 1,2,3 Legocki, Andrzej B. 1,2,3 Filipowicz, Witold 1,2,3; Affiliation: 1: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 2: Institute of Biochemistry, University of Agriculture, Poznań 3: National Institutes of Health, Bethesda, Maryland; Source Info: 12/1/78, Vol. 92 Issue 1, p69; Subject Term: MESSENGER RNA; Subject Term: PLANT viruses; Subject Term: GLOBIN genes; Subject Term: NUCLEOTIDES; Subject Term: PYROPHOSPHATES; Subject Term: ADENOSYLMETHIONINE; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Merchant, B.
AU - Johannessen, L.
AU - Inman, J. K.
T1 - Effects of cyclophosphamide on the in vivo response of outbred athymic (nude) mice to a thymus-independent antigen (DNP-AGG-Ficoll).
JO - Immunology
JF - Immunology
Y1 - 1978/12//
VL - 35
IS - 6
M3 - Article
SP - 1009
EP - 1015
PB - Wiley-Blackwell
SN - 00192805
AB - Both nude mice (nu/nu) and their heterozygous littermates (nu/+) were injected with a single IP dose of 300 mg cyclophosphamide (CY)/kg. CY is a known immunosuppressive agent, which affects primarily B lymphocytes. Immunization with the thymus independent antigen DNP-AGG59- Ficoll after CY treatment disclosed that restoration of the primary direct PFC response occurred more rapidly in nude mice than in nu/+ mice. However in these same experiments, the primary indirect PFC response, recovered earlier in nu/+ mice than in nude mice. After CY treatment, secondary indirect PFC responses were delayed in both nude and nu/+ mice, but the greatest effect was seen in nude mice. The data suggest that the presence of T cells has little if any influence on the recovery capacity of those B cells which are destined to become direct PFC. However the recovery of B cells which are destined to produce indirect PFC responses is facilitated by the presence of T cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOTHERAPY
KW - THYMUS
KW - ANTIGENS
KW - FICOLL
KW - LYMPHOCYTES
KW - B cells
KW - T cells
KW - ANTIGEN presenting cells
N1 - Accession Number: 15789199; Snippe, H. 1,2 Merchant, B. 1,2 Johannessen, L. 1,2 Inman, J. K. 1,2; Affiliation: 1: Division of Blood and Blood Products, Bureau of Biologies, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20014 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Source Info: Dec78, Vol. 35 Issue 6, p1009; Subject Term: IMMUNIZATION; Subject Term: IMMUNOTHERAPY; Subject Term: THYMUS; Subject Term: ANTIGENS; Subject Term: FICOLL; Subject Term: LYMPHOCYTES; Subject Term: B cells; Subject Term: T cells; Subject Term: ANTIGEN presenting cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gail, Mitchell H.
AU - Gastwirth, Joseph L.
T1 - A Scale-Free Goodness-of-Fit Test for the Exponential Distribution Based on the Lorenz Curve.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1978/12//
VL - 73
IS - 364
M3 - Article
SP - 787
SN - 01621459
AB - The sample Lorenz curve provides a powerful, easily computed goodness-of-fit test for exponentiality which does not depend on the unknown scale parameter. Exact critical values and asymptotic results are given, which can also be used to test the related hypothesis of randomness on an interval. General limit theorems show that the sample Lorenz curve converges almost surely to the population Lorenz curve and that the standardized Lorenz statistic converges to normality provided the underlying random variable has finite variance. Asymptotic relative efficiencies and Monte Carlo power estimates are also given. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LORENZ curve
KW - DISTRIBUTION (Probability theory)
KW - MONTE Carlo method
KW - MATHEMATICAL statistics
KW - GOODNESS-of-fit tests
KW - EXPONENTIAL families (Statistics)
KW - LIMIT theorems (Probability theory)
KW - HYPOTHESIS
KW - Concentration curve
KW - Exponential distribution
KW - Goodness of fit
KW - Lorenz curve
KW - Randomness on an interval.
N1 - Accession Number: 4605617; Gail, Mitchell H. 1; Gastwirth, Joseph L. 2; Affiliations: 1: Medical statistician, National Cancer Institute, Landow C509, Bethesda, MD 20014.; 2: Professor of Statistics and Economics, George Washington University, Washington, DC 20052.; Issue Info: Dec78, Vol. 73 Issue 364, p787; Thesaurus Term: LORENZ curve; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: MONTE Carlo method; Thesaurus Term: MATHEMATICAL statistics; Subject Term: GOODNESS-of-fit tests; Subject Term: EXPONENTIAL families (Statistics); Subject Term: LIMIT theorems (Probability theory); Subject Term: HYPOTHESIS; Author-Supplied Keyword: Concentration curve; Author-Supplied Keyword: Exponential distribution; Author-Supplied Keyword: Goodness of fit; Author-Supplied Keyword: Lorenz curve; Author-Supplied Keyword: Randomness on an interval.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rogan, Walter J.
T1 - Clinical Biostatistics (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1978/12//
VL - 73
IS - 364
M3 - Book Review
SP - 897
SN - 01621459
AB - Reviews the book "Clinical Biostatistics," by Alvan R. Feinstein.
KW - BIOMETRY
KW - NONFICTION
KW - FEINSTEIN, Alvan
KW - FEINSTEIN, Alvan R.
KW - CLINICAL Biostatistics (Book)
N1 - Accession Number: 4606841; Rogan, Walter J. 1; Affiliations: 1: National Institute of Environmental Health Sciences.; Issue Info: Dec78, Vol. 73 Issue 364, p897; Subject Term: BIOMETRY; Subject Term: NONFICTION; Reviews & Products: CLINICAL Biostatistics (Book); People: FEINSTEIN, Alvan; People: FEINSTEIN, Alvan R.; Number of Pages: 1/4p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - MARGULES, DAVID L.
AU - MOISSET, BEATRIZ
AU - LEWIS, MICHAEL J.
AU - SHIBUYA, HARUO
AU - PERT, CANDACE B.
T1 - ß-Endorphin Is Associated with Overeating in Genetically Obese Mice (ob/ob) and Rats (fa/fa).
JO - Science
JF - Science
Y1 - 1978/12//12/ 1/1978
VL - 202
IS - 4371
M3 - Article
SP - 988
EP - 991
SN - 00368075
AB - Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (falfa). Elevated concentrations of the naturally occurring opiate ß-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of ß-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary ß- endorphin may play a role in the development of the overeating and obesity syndrome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218746; MARGULES, DAVID L. 1; MOISSET, BEATRIZ 1; LEWIS, MICHAEL J. 2; SHIBUYA, HARUO 3; PERT, CANDACE B. 3; Affiliations: 1: Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122; 2: Department of Psychology, Tufts University, Medford, Massachusetts 02155; 3: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/ 1/1978, Vol. 202 Issue 4371, p988; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BIRD, STEPHANIE J.
AU - GULLEY, ROBERT L.
AU - WENTHOLD, ROBERT J.
AU - FEX, JÖRGEN
T1 - Kainic Acid Injections Result in Degeneration of Cochlear Nucleus Cells Innervated by the Auditory Nerve.
JO - Science
JF - Science
Y1 - 1978/12/08/
VL - 202
IS - 4372
M3 - Article
SP - 1087
EP - 1089
SN - 00368075
AB - When kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. The rate and extent of degeneration is correlated with the distribution of the primary auditoryfibers. This evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218778; BIRD, STEPHANIE J. 1; GULLEY, ROBERT L. 2; WENTHOLD, ROBERT J. 3; FEX, JÖRGEN 3; Affiliations: 1: Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106; 2: Department of Anatomy, School of Medicine, Case Western Reserve University; 3: Laboratory of Neuro-otolaryngology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1087; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MACLEOD, COLIN M.
AU - DEKABAN, ANATOLE S.
AU - HUNT, EARL
T1 - Memory Impairment in Epileptic Patients: Selective Effects of Phenobarbital Concentration.
JO - Science
JF - Science
Y1 - 1978/12/08/
VL - 202
IS - 4372
M3 - Article
SP - 1102
EP - 1104
SN - 00368075
AB - Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218784; MACLEOD, COLIN M. 1; DEKABAN, ANATOLE S. 2; HUNT, EARL 3; Affiliations: 1: Department of Psychology, University of Washington, Seattle 98195; 2: Developmental and Metabolic Neurology Branch, National Institutes of Health Bethesda, Maryland 20014; 3: Department of Psychology, University of Washington; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1102; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ALLING, DAVID W.
AU - HALPERIN, MAX
AU - WARE, JAMES H.
AU - TUKEY, JOHN W.
T1 - Controlled Clinical Trials.
JO - Science
JF - Science
Y1 - 1978/12/08/
VL - 202
IS - 4372
M3 - Article
SP - 1105
EP - 1105
SN - 00368075
N1 - Accession Number: 85218785; ALLING, DAVID W. 1; HALPERIN, MAX 1; WARE, JAMES H. 1; TUKEY, JOHN W. 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20014; 2: Bell Laboratories, Murray Hill, New Jersey 07974; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1105; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BROWN, CHARLES C.
AU - FEARS, THOMAS R.
AU - GAIL, MITCHELL H.
AU - SCHNEIDERMAN, MARVIN A.
AU - TARONE, ROBERT E.
AU - MANTEL, NATHAN
AU - MCGAUGHEY, CHARLES
AU - CRUMP, KENNY S.
AU - NEYMAN, JERZY
AU - SCHERER, E.
AU - EMMELOT, P.
AU - CORNFIELD, JEROME
T1 - Models for Carcinogenic Risk Assessment.
JO - Science
JF - Science
Y1 - 1978/12/08/
VL - 202
IS - 4372
M3 - Article
SP - 1105
EP - 1109
SN - 00368075
N1 - Accession Number: 85218786; BROWN, CHARLES C. 1; FEARS, THOMAS R. 1; GAIL, MITCHELL H. 1; SCHNEIDERMAN, MARVIN A. 1; TARONE, ROBERT E. 1; MANTEL, NATHAN 2; MCGAUGHEY, CHARLES 3; CRUMP, KENNY S. 4; NEYMAN, JERZY 5; SCHERER, E. 6; EMMELOT, P. 6; CORNFIELD, JEROME 7; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20014; 2: Biostatistics Center, George Washington University, Bethesda, Maryland 20014; 3: Oral Diseases Research Laboratory, Veterans Administration Hospital, Long Beach, California 90822; 4: Department of Mathematics and Statistics, Louisiana Tech University, Ruston 71272; 5: Statistical Laboratory, University of California, Berkeley 94720; 6: Division of Chemical Carcinogenesis, Antoni van Leeuwenhoek-Huis, Netherlands Cancer Institute, Amsterdam, Netherlands; 7: Department of Statistics, Biostatistics Center, George Washington University, Bethesda, Maryland 20014; Issue Info: 12/ 8/1978, Vol. 202 Issue 4372, p1105; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CUMMINGS, MARTIN M.
T1 - Informtion Tiansfer: The Biomedical Model.
JO - Science
JF - Science
Y1 - 1978/12/22/
VL - 202
IS - 4374
M3 - Article
SP - 1249
EP - 1249
SN - 00368075
N1 - Accession Number: 85218830; CUMMINGS, MARTIN M. 1; Affiliations: 1: National Library of Medician, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1249; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YATVIN, MILTON B.
AU - WEINSTEIN, JOHN N.
AU - DENNIS, WARREN H.
AU - BLUMENTHAL, ROBERT
T1 - Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia.
JO - Science
JF - Science
Y1 - 1978/12/22/
VL - 202
IS - 4374
M3 - Article
SP - 1290
EP - 1293
SN - 00368075
AB - Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44°C to that at 37°C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218853; YATVIN, MILTON B. 1; WEINSTEIN, JOHN N. 2; DENNIS, WARREN H. 3; BLUMENTHAL, ROBERT 4; Affiliations: 1: Radiobiology Research Laboratories, Department of Human Oncology, University of Wisconsin, Madison 53706; 2: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Departments of Physiology and Preventive Medicine, University of Wisconsin, Madison; 4: Laboratory of Theoretical Biology, National Cancer Institute; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1290; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HENKART, MARYANNA P.
AU - REESE, T. S.
AU - BRINLEY JR., F. J.
T1 - Endoplasmic Reticulum Sequesters Calcium in the Squid Giant Axon.
JO - Science
JF - Science
Y1 - 1978/12/22/
VL - 202
IS - 4374
M3 - Article
SP - 1300
EP - 1303
SN - 00368075
AB - Axons were loaded with calcium, rapidly frozen, andfreeze-substituted. The endoplasmic reticulum, in addition to mitochondria, contained calcium deposits, as indicated by electron probe x-ray microanalysis. Oxalate injected into living axons helped to preserve calcium-containing deposits during preparation for microscopy. It is concluded that the endoplasmic reticulum is a calcium-sequestering compartment in the squid giant axon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218857; HENKART, MARYANNA P. 1; REESE, T. S. 2; BRINLEY JR., F. J. 3; Affiliations: 1: Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014; 2: National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014; 3: Department of Physiology, University of Maryland School of Medicine, Baltimore 21201; Issue Info: 12/22/1978, Vol. 202 Issue 4374, p1300; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-02065-000
AN - 9999-02065-000
AU - Achenbach, Thomas M.
AU - Edelbrock, Craig S.
T1 - Child Behavior Profile
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1979///
AD - Achenbach, Thomas M., National Institute of Mental Health, Laboratory of Developmental Psychology, 9000 Rockville Pike, Building 15K, 20014, Maryland, United States, 20014
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-02065-000. Other Names: Youth Self-Report Questionnaire. Acronyms: YSRQ. Partial author list: First Author & Affiliation: Achenbach, Thomas M.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111010. Correction Date: 20151109. Language: English. Constructs: Behavioral Problems; Competency-Related Behavior; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Other Versions: 9999-20906-000, Behavioral Functioning Measure, Revision.
N2 - Administration Method: Paper
AB - Purpose: The Child Behavior Profile measures behavioral problems and competencies standardized for each sex at ages 4 to 5, 6 to 11, and 12 to 16.
AB - Description: The Child Behavior Profile (Achenbach & Edelbrock, 1979) is a measure of behavioral problems and competencies standardized for each sex at ages 4 to 5, 6 to 11, and 12 to 16. Scored from the Child Behavior Checklist, the profile consists of three a priori social competence scales plus behavior problem scales that were derived through factor analysis of the checklists filled out by parents of 450 children of each sex and age group referred for mental health services. The behavior problem scales were labeled as follows: boys 12-16—Somatic Complaints, Schizoid, Uncommunicative, Immature, Obsessive-Compulsive, Hostile Withdrawal, Delinquent, Aggressive, and Hyperactive; girls 6-11—Somatic Complaints, Schizoid-Obsessive, Depressed, Social Withdrawal, Sex Problems, Cruel, Delinquent, Aggressive, and Hyperactive; girls 12-16—Somatic Complaints, Schizoid, Depressed Withdrawal, Anxious-Obsessive, Immature-Hyperactive, Cruel, Aggressive, and Delinquent. Second-order factor analyses showed that the behavior problem scales for each sample could be divided into broadband groupings called internalizing and externalizing. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Child Behavior Profiles
KW - Externalizing Behavior Problems
KW - Internalizing Behavior Problems
KW - Social Competencies
KW - Test Development
U5 - Child Behavior Profile (YSRQ) [Test Development]The Child Behavior Profile: II. Boys aged 12–16 and girls aged 6–11 and 12–16. (AN: 1979-27624-001 from PsycINFO) Achenbach, Thomas M.; Edelbrock, Craig S.; Apr, 1979. Source: Journal of Consulting and Clinical Psychology. 47(2), American Psychological Association, US; Apr, 1979; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs); Population: Human; Male; Female; Location: United States; Samples: 12-16 Yr Olds Being Evaluated in Mental Health Settings and their Parents Keywords: Child Behavior Profiles; Externalizing Behavior Problems; Internalizing Behavior Problems; Social Competencies; Test Development; Subjects: Behavior Problems; Child Behavior Checklist; Externalization; Internalization; Profiles (Measurement); Social Skills; Test Construction; Test Forms;
DO - 10.1037/t02065-000
L3 - Full; Full text; 999902065_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Hijmans, W.
AU - Sipe, Jean D.
T1 - Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/01//
VL - 35
IS - 1
M3 - Article
SP - 96
EP - 100
PB - Wiley-Blackwell
SN - 00099104
AB - Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 2 μg/ml, with only five serum samples tailing below 5 μg/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMYLOID beta-protein
KW - GLYCOPROTEINS
KW - AGE groups
KW - SERUM
KW - IMMUNOGLOBULINS
KW - AMYLOID
N1 - Accession Number: 16616378; Hijmans, W. 1 Sipe, Jean D. 2; Affiliation: 1: The Laboratory of Experimental Pathology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, USA. 2: Institute for Experimental Gerontology TNO. Rijswijk, The Netherlands.; Source Info: Jan1979, Vol. 35 Issue 1, p96; Subject Term: AMYLOID beta-protein; Subject Term: GLYCOPROTEINS; Subject Term: AGE groups; Subject Term: SERUM; Subject Term: IMMUNOGLOBULINS; Subject Term: AMYLOID; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Butler, Robert N.
T1 - Sexual intimacy for older folks.
JO - Geriatrics
JF - Geriatrics
Y1 - 1979/01//
VL - 34
IS - 1
M3 - Article
SP - 9
EP - 9
SN - 0016867X
N1 - Accession Number: 17333461; Butler, Robert N. 1; Source Information: Jan1979, Vol. 34 Issue 1, p9; Number of Pages: 1/3p; Document Type: Article; Full Text Word Count: 207
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DP - EBSCOhost
DB - hch
ER -
TY - CHAP
ID - 1990-98082-023
AN - 1990-98082-023
AU - Goldberg, Irving D.
AU - Krantz, Goldie
AU - Locke, Ben Z.
ED - Kiesler, Charles A.
ED - Cummings, Nicholas A.
ED - VandenBos, Gary R.
ED - Kiesler, Charles A., (Ed)
ED - Cummings, Nicholas A., (Ed)
ED - VandenBos, Gary R., (Ed)
T1 - Effect of a short-term outpatient psychiatric therapy benefit on the utilization of medical services in a prepaid group practice medical program.
T2 - Psychology and national health insurance: A sourcebook.
Y1 - 1979///
SP - 234
EP - 242
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-13-6
SN - 0-912704-11-X
N1 - Accession Number: 1990-98082-023. Partial author list: First Author & Affiliation: Goldberg, Irving D.; National Institute of Mental Health, Biometry Branch, Evaluation Studies Section, Chevy Chase, MD, US. Release Date: 19900101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-13-6, Hardcover; 0-912704-11-X, Paperback. Language: English. Major Descriptor: Brief Psychotherapy; Health Care Utilization; Outpatient Treatment; Psychiatric Patients. Minor Descriptor: Health Insurance; Outpatients. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 9.
AB - This chapter is reprinted from MEDICAL CARE © J. B. Lippincott Company, 1970, 8, 419-428, by permission. A pilot study was conducted to measure the effect of a short-term outpatient psychiatric therapy benefit on the utilization of general medical services at Group Health Association of Washington, D.C. (GHA), a Prepaid group practice medical program. The study group consisted of 256 patients who were referred for such outpatient therapy and who were GHA members for a full 12-month period both before and after the psychiatric referral. Study patients experienced a marked reduction during the year after referral as compared with the prior year in the utilization of GHA nonpsychiatric physician services and laboratory or x-ray procedures. The reduction in number of patients seen was 13.6 per cent for nonpsychiatric physician services, and 75.7 per cent for laboratory or x-ray procedures. In terms of visits made, reduction was approximately 30 per cent for each of these services. Basic finding of reduced utilization was still obtained when factors of age, race, sex, psychiatric diagnosis, and number of therapy sessions attended under benefit were taken into account. Results support findings of reduced utilization in other studies and suggest more efficient utilization of appropriate medical services as a result of short-term outpatient mental health benefits in prepaid health plan settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - brief psychiatric therapy
KW - outpatient therapy
KW - medical service utilization
KW - prepaid health plan subscribers
KW - 1979
KW - Brief Psychotherapy
KW - Health Care Utilization
KW - Outpatient Treatment
KW - Psychiatric Patients
KW - Health Insurance
KW - Outpatients
KW - 1979
DO - 10.1037/10070-023
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1990-98082-033
AN - 1990-98082-033
AU - Liptzin, Benjamin
AU - Stockdill, James W.
AU - Brown, Bertram S.
ED - Kiesler, Charles A.
ED - Cummings, Nicholas A.
ED - VandenBos, Gary R.
ED - Kiesler, Charles A., (Ed)
ED - Cummings, Nicholas A., (Ed)
ED - VandenBos, Gary R., (Ed)
T1 - A federal view of mental health program evaluation.
T2 - Psychology and national health insurance: A sourcebook.
Y1 - 1979///
SP - 314
EP - 320
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-13-6
SN - 0-912704-11-X
N1 - Accession Number: 1990-98082-033. Partial author list: First Author & Affiliation: Liptzin, Benjamin; National Institute of Mental Health, Office of Program Development and Analysis, Program Analysis and Evaluation Branch, Rockville, MD, US. Release Date: 19900101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. ISBN: 0-912704-13-6, Hardcover; 0-912704-11-X, Paperback. Language: English. Major Descriptor: Community Mental Health Centers; Government Agencies; Mental Health Program Evaluation; Mental Health Programs. Minor Descriptor: Management Decision Making; Politics; Quality Control; Quality of Care; Quality of Services. Classification: Health & Mental Health Services (3370). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 7.
AB - This chapter is reprinted from Professional Psychology, 1977, 8, 543-552. This article discusses the current thinking at the National Institute of Mental Health on what evaluation is, who it is directed to, how it can be used, and what other activities relate to it. The article discusses the sections of the Community Mental Health Centers Amendments of 1975 that relate to program evaluation, quality assurance, and standards. The relationship of quality assurance activities to private office practice is also addressed. Evaluation is discussed in relation to decision making from two points of view: political and management. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - National Institute of Mental Health
KW - mental health program evaluation
KW - community mental health centers
KW - quality assurance
KW - political decision making
KW - management decision making
KW - 1979
KW - Community Mental Health Centers
KW - Government Agencies
KW - Mental Health Program Evaluation
KW - Mental Health Programs
KW - Management Decision Making
KW - Politics
KW - Quality Control
KW - Quality of Care
KW - Quality of Services
KW - 1979
DO - 10.1037/10070-033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1990-98082-033&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chang, Lana Fourshee
AU - Chang, Lana Foushee
T1 - HOW TO SUCCEED WITH WET-TO-DRY DRESSINGS.
JO - RN
JF - RN
Y1 - 1979/01//
VL - 42
IS - 1
M3 - Article
SP - 63
EP - 66
SN - 00337021
AB - Presents guidelines for nurses on applying wet-to-dry dressings. Function of wet-to-dry dressings to debride the wound; Step-by-step guide to proper procedure; Selection of the right type of solution used to soak the dressing. INSET: WET-TO-DRY DRESSINGS: Step-by-Step guide to proper....
KW - SURGICAL dressings
KW - WOUNDS & injuries -- Treatment
N1 - Accession Number: 4878721; Chang, Lana Fourshee; Chang, Lana Foushee 1; Source Information: Jan79, Vol. 42 Issue 1, p63; Subject: SURGICAL dressings; Subject: WOUNDS & injuries -- Treatment; Number of Pages: 4p; Illustrations: 10 Black and White Photographs; Document Type: Article; Full Text Word Count: 1694
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=4878721&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Doszkocs, Tamas E
AU - Rapp, Barbara A
T1 - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
JO - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
JF - Searching medline in english: a prototype user interface with natural language query, ranked output, and relevance feedback
Y1 - 1979///
M3 - Book
AB - Developing an english sentence (natural language) query capability for today's operational online retrieval systems promises to have profound impact on bibliographical retrieval. Althouth much research has been done over the past two decades, experimental systems have not been implemented in a large operational environment. In a prototype system called cite (current information transfer in english), the authors have demonstrated a technical solution for implementing an operational natural language interface to medline, the most heavily used of nlm's 19 data bases. Important in the design of the system were the functional considerations of: identification of search terms; combinatorial searching; weighting and ranked output; relevance feedback; and automatic query modification. Technical considerations focused on maintenance of quick response time and internal efficiency. Of critical importance was the solution of the technical problems of 1) merging postings lists to achieve the logical equivalent of combinatorial searching and 2) computing document ranking weights. The principles employed in the system design are of a general nature and can be transferres to any inverted file system
N1 - Accession Number: ISTA1500490; Doszkocs, Tamas E 1; Rapp, Barbara A 2; Affiliations: 1 : National Cancer Institute; 2 : Nlm; Source Info: 1979; Note: Update Code: 1500; Document Type: Book
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1500490&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2013-42954-003
AN - 2013-42954-003
AU - Davenport, Yolande B.
AU - Adland, Marvin L.
AU - Gold, Philip W.
AU - Goodwin, Frederick K.
T1 - Manic-depressive illness: Psychodynamic features of multigenerational families.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1979/01//
VL - 49
IS - 1
SP - 24
EP - 35
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Davenport, Yolande B., Unit on Family Studies, Clinical Psychobiology Branch, NIMH, Clinical Center, Room 4S-239, Bethesda, MD, US, 20014
N1 - Accession Number: 2013-42954-003. PMID: 758801 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Psychodynamics; Self-Esteem. Minor Descriptor: Family; Fear; Heritability; Intergenerational Relations. Classification: Affective Disorders (3211); Psychoanalytic Therapy (3315). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: Hollingshead-Redlich Scale. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979.
AB - Psychodynamic features of families with multigenerational bipolar manic-depressive illness are described. Repetitive maladaptive patterns, including avoidance of affect, unrealistic standards of conformity, absence of intimate relationships apart from family, displaced parental low self-esteem, and fears related to illness heritability, may influence the maintenance of family pathology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - manic depressive illness
KW - psychodynamic features
KW - multigenerational families
KW - self esteem
KW - fears
KW - 1979
KW - Bipolar Disorder
KW - Psychodynamics
KW - Self-Esteem
KW - Family
KW - Fear
KW - Heritability
KW - Intergenerational Relations
KW - 1979
DO - 10.1111/j.1939-0025.1979.tb02582.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42954-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42954-010
AN - 2013-42954-010
AU - Goldstein, Carole G.
AU - Koopman, Elizabeth J.
AU - Goldstein, Harold H.
T1 - Racial attitudes in young children as a function of interracial contact in the public schools.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1979/01//
VL - 49
IS - 1
SP - 89
EP - 99
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Goldstein, Harold H., Staff College, National Institute of Mental Health, 5635 Fishers Lane, Rockville, MD, US, 20852
N1 - Accession Number: 2013-42954-010. PMID: 758808 Partial author list: First Author & Affiliation: Goldstein, Carole G.; Institute for Child Study, University of Maryland, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blacks; Public School Education; Racial and Ethnic Attitudes; Racial and Ethnic Relations; Student Attitudes. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Show Me Test; Racial Stereotyping Test. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979.
AB - The relative effects of integrated and segregated schooling on racial attitudes were studied in a comparison of young children attending all-black, all-white, and integrated schools. Results of this photo-choice study suggest that segregated classes discourage realistic perceptions of the excluded race and promote a preference for whites among whites and blacks, whereas interracial schooling contributes to acceptance of blacks by all students and has especially profound and complex effects on black children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial attitudes
KW - interracial contacts
KW - public schools
KW - Black children
KW - 1979
KW - Blacks
KW - Public School Education
KW - Racial and Ethnic Attitudes
KW - Racial and Ethnic Relations
KW - Student Attitudes
KW - 1979
DO - 10.1111/j.1939-0025.1979.tb02589.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42954-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42954-026
AN - 2013-42954-026
AU - Shore, Milton F.
T1 - Review of Too great expectations: The academic outlook of young children.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1979/01//
VL - 49
IS - 1
SP - 181
EP - 182
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42954-026. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National institute of Mental Health, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Academic Achievement; Aspiration Level; School Environment. Minor Descriptor: Elementary School Students; Expectations; Lower Class. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Reviewed Item: Entwisle, Doris R.; Hayduk, Leslie A. Too great expectations: The academic outlook of young children=193 pp. $12.95. John Hopkins University Press, Baltimore; 1978. Page Count: 2. Issue Publication Date: Jan, 1979.
AB - Reviews the book, Too great expectations: The Academic Outlook of Young Children by Doris R. Entwisle and Leslie A. Hayduk (1978). The authors have carried out a large sociological study of two cohorts of school children from the first grade of two schools in the city of Baltimore, Maryland-one in a lower-class area and the other in a middle-class area. Some of the findings are of interest. The authors found that all first-grade children predicted extremely high grades. Their predictions were more unrealistic than those of their parents. The authors are appropriately concerned with the effect on lower-class children of negative feedback in school. They wish to intervene in the schools to assist lower-class children. But is it best to reduce lower-class children's aspiration level to match outcome as measured by grades, as the authors suggest? Or is it more appropriate to alter the total educational approach to these children? The greatest failing of this work is suggested by its own title-the authors' too great expectations of their data. One needs to be concerned with school settings, and expectations are important. But believing that expectations as measured by grades, received or predicted, will be the panacea for all academic difficulties in lower-class children is certainly not warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - academic outlook
KW - young children
KW - lower class children
KW - school settings
KW - aspiration level
KW - 1979
KW - Academic Achievement
KW - Aspiration Level
KW - School Environment
KW - Elementary School Students
KW - Expectations
KW - Lower Class
KW - 1979
U2 - Entwisle, Doris R.; Hayduk, Leslie A. (1978); Too great expectations: The academic outlook of young children; 193 pp. $12.95. John Hopkins University Press, Baltimore
DO - 10.1037/h0098872
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42954-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05560-001
AN - 2009-05560-001
AU - Usdin, Eari
T1 - 'Endorphins, dopamine, and schizophrenia': Two discussions: II.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1979///
VL - 5
IS - 2
SP - 242
EP - 243
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Usdin, Eari, Pharmacology Section, Psychopharmacology Research Branch, Rm. 9-95, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2009-05560-001. Partial author list: First Author & Affiliation: Usdin, Eari; Pharmacology Section, Psychopharmacology Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Dopamine; Etiology; Neurochemistry; Peptides; Schizophrenia. Minor Descriptor: Endorphins. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 2. Issue Publication Date: 1979.
AB - Comments on the original article 'Endorphins, dopamine, and schizophrenia,' by J. Volavka, L. G. Davis, and Y. H. Ehrlich (see record [rid]1981-12979-001[/rid]). Although studies using endorphins may well prove valuable in our understanding of the etiology of schizophrenia and may even lead to new and effective psychotherapeutic agents, this discussant concludes that it is premature to suggest that either beta-endorphin or an analogue has been demonstrated to be an antipsychotic agent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - endorphin system alteration
KW - dopaminergic neuronal hyperactivity
KW - etiology
KW - schizophrenia
KW - 1979
KW - Dopamine
KW - Etiology
KW - Neurochemistry
KW - Peptides
KW - Schizophrenia
KW - Endorphins
KW - 1979
DO - 10.1093/schbul/5.2.242
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05560-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05554-001
AN - 2009-05554-001
AU - Matthews, Susan M.
AU - Mosher, Loren R.
AU - Roper, Margaret T.
AU - Menn, Alma Z.
T1 - 'Non-neuroleptic treatment for schizophrenia': The authors reply.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1979///
VL - 5
IS - 4
SP - 566
EP - 567
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Matthews, Susan M., Center for Studies of Schizophrenia National Institute of Mental Health, Rockville, MD, US, 20857
N1 - Accession Number: 2009-05554-001. Partial author list: First Author & Affiliation: Matthews, Susan M.; Center for Studies of Schizophrenia, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Neuroleptic Drugs; Schizophrenia; Treatment Effectiveness Evaluation. Minor Descriptor: Psychiatric Hospital Discharge; Relapse (Disorders); Therapeutic Community. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1979.
AB - Responds to the comments by A. Rifkin (see record [rid]2009-05555-001[/rid]) on the current authors' original article (see record [rid]1981-13171-001[/rid]). The authors address the five major points raised by Rifkin: (1) Sample selection; (2) Criteria for rehospitalization; (3) The findings of Klein and Rosen (1973); (4) The meaning of 'purely clinical' decision; and (5) Relapse rates and selection criteria. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroleptic vs intensive psychosocial milieu treatment
KW - relapse
KW - residential care discharge
KW - first-admission schizophrenics
KW - 1979
KW - Drug Therapy
KW - Neuroleptic Drugs
KW - Schizophrenia
KW - Treatment Effectiveness Evaluation
KW - Psychiatric Hospital Discharge
KW - Relapse (Disorders)
KW - Therapeutic Community
KW - 1979
DO - 10.1093/schbul/5.4.566
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05554-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SHINOHARA, MAMI
AU - DOLLINGER, BETH
AU - BROWN, GWEN
AU - RAPOPORT, STANLEY
AU - SOKOLOFF, Louis
T1 - Cerebral Glucose Utilization: Local Changes During and After Recovery from Spreading Cortical Depression.
JO - Science
JF - Science
Y1 - 1979/01/12/
VL - 203
IS - 4376
M3 - Article
SP - 188
EP - 190
SN - 00368075
AB - Cerebral glucose utilization is markedly increased in most areas of the cerebral cortex and reduced in many subcortical structures during spreading cortical depression. During recovery, cortical glucose utilization is still elevated, but the increased metabolic activity is distributed in columns running perpendicularly through the cortex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218894; SHINOHARA, MAMI 1; DOLLINGER, BETH 1; BROWN, GWEN 1; RAPOPORT, STANLEY 2; SOKOLOFF, Louis 3; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Laboratory of Neurosciences, National Institute of Aging, Baltimore, Maryland 21224; 3: Laboratory of Cerebral Metabolism, National Institute of Mental Health; Issue Info: 1/12/1979, Vol. 203 Issue 4376, p188; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VANDENBURGH, HERMAN
AU - KAUFMAN, SEYMOUR
T1 - In vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle.
JO - Science
JF - Science
Y1 - 1979/01/19/
VL - 203
IS - 4377
M3 - Article
SP - 265
EP - 268
SN - 00368075
AB - Mechanical stretch of embryonic chicken skeletal myotubes developed in vitro leads to many of the biochemical changes seen in skeletal muscle hypertrophy. These include increased amino acid accumulation, increased incorporation of amino acids into general cellular proteins and myosin heavy chains, and increased accumulation of total protein and myosin heavy chains. This model system should aid in understanding how the growth rate of skeletal muscle is regulated by its activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268674; VANDENBURGH, HERMAN 1; KAUFMAN, SEYMOUR 1; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/19/1979, Vol. 203 Issue 4377, p265; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=85268674&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZATZ, MARTIN
AU - BROWNSTEIN, MICHAEL J.
T1 - Intraventricular Carbachol Mimics the Effects of Light on the Circadian Rhythm in the Rat Pineal Gland.
JO - Science
JF - Science
Y1 - 1979/01/26/
VL - 203
IS - 4378
M3 - Article
SP - 358
EP - 361
SN - 00368075
AB - Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361475; ZATZ, MARTIN 1; BROWNSTEIN, MICHAEL J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 1/26/1979, Vol. 203 Issue 4378, p358; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=85361475&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DURAN, ANGEL
AU - CABIB, ENRICO
AU - BOWERS, BLAIR
T1 - Chitin Synthetase Distribution on the Yeast Plasma Membrane.
JO - Science
JF - Science
Y1 - 1979/01/26/
VL - 203
IS - 4378
M3 - Article
SP - 363
EP - 365
SN - 00368075
AB - Purified, intact yeast plasma membranes were allowed to synthesize chitin, and the nascent chains of polysaccharide were observed either by the fluorescence produced with a brightener or by autoradiography. By both methods, it was concluded that the newly formed chitin emerged at many sites on each membrane. Thus, the synthetase that catalyzes chitin formation has a similar distribution. Since chitin synthetase is found mainly in a zymogen form, these results confirm the hypothesis that initiation of the chitinous primary septum of Saccharomyces occurs by localized activation of the uniformly distributed zymogen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361477; DURAN, ANGEL 1; CABIB, ENRICO 1; BOWERS, BLAIR 2; Affiliations: 1: National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014; 2: National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; Issue Info: 1/26/1979, Vol. 203 Issue 4378, p363; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=85361477&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boice, John D.
AU - Land, Charles E.
T1 - Adult Leukemia Following Diagnostic X-Rays?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/02//
VL - 69
IS - 2
M3 - Article
SP - 137
PB - American Public Health Association
SN - 00900036
AB - The article discusses the study on adult leukemia following diagnostic x-rays. According to the study, the association between leukemia and diagnostic x-ray may be entirely due to a few individuals who received massive diagnostic radiation exposures. The study has showed that several researches linking diagnostic radiation with adult non-lymphocytic leukemia have been reported in England, New Zealand and the U.S. Each of the researches have reported an association in adults between diagnostic x-rays and myeloid leukemia, but not lymphatic leukemia.
KW - PUBLIC health research
KW - ADULT T-cell leukemia
KW - LYMPHOCYTIC leukemia
KW - MYELOID leukemia
KW - X-rays
KW - RADIATION exposure
KW - RADIOISOTOPES in medical diagnosis
KW - MEDICAL research
KW - MEDICAL technology
N1 - Accession Number: 6009224; Boice, John D. 1 Land, Charles E. 1; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute.; Source Info: Feb1979, Vol. 69 Issue 2, p137; Subject Term: PUBLIC health research; Subject Term: ADULT T-cell leukemia; Subject Term: LYMPHOCYTIC leukemia; Subject Term: MYELOID leukemia; Subject Term: X-rays; Subject Term: RADIATION exposure; Subject Term: RADIOISOTOPES in medical diagnosis; Subject Term: MEDICAL research; Subject Term: MEDICAL technology; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miles, F. A.
AU - Evarts, E. V.
T1 - CONCEPTS OF MOTOR ORGANIZATION.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1979/02//
VL - 30
IS - 1
M3 - Article
SP - 327
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11265210; Miles, F. A. 1 Evarts, E. V. 1; Affiliation: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014.; Source Info: 1979, Vol. 30 Issue 1, p327; Number of Pages: 36p; Document Type: Article
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ER -
TY - JOUR
AU - Zopi, David A.
AU - Ginsburg, Victor
AU - Hallgren, Peter
AU - Jonsson, Anne-Charlotte
AU - Lindbi, Bo S.
AU - Arne Lundbland
T1 - Determination of Leb-Active Oligosaccharides in Urine of Pregant and Lactating Women by Radioimmunoassay.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/02//2/1/79
VL - 93
IS - 3
M3 - Article
SP - 431
EP - 435
PB - Wiley-Blackwell
SN - 00142956
AB - Antiserum obtained by immunizing a goat with lacto-N-difucohexaose L a Leb blood-grouphapten. coupled to poly-L-lysine was used in a radioimmunoassay to detect Leb-active oligosaccharides (chiefly lacto-N-difucohexaose I) in urine of 138 pregnant and lactating women of different ABO and Lewis blood groups. Specificity of the method was determined by comparing inhibitory activities of 18 oligosaccharides. Only women who belonged to the Leb blood group excreted Leb-active oligosaccharides in urine. Leb-active oligosaccharides increase during pregnancy reaching levels up to approximately 70 μmol lacto-N-difucohexaose I equivalents per pmol creatinine in the third trimester and early post-partum period. Excretion varies considerable but tends to be highest in those individuals who strongly express the Leb antigen on their red blood cells or who belong to blood group O. Leb-active oligosaccharides were detected in plasma of a few individuals but at concentrations 1000-fold lower than in urine. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXAMINATION of the blood
KW - OLIGOSACCHARIDES
KW - EXCRETION
KW - BLOOD transfusion
KW - PHYSIOLOGY
KW - BLOOD cells
N1 - Accession Number: 13603837; Zopi, David A. 1 Ginsburg, Victor 1,2,3 Hallgren, Peter 1,2,3 Jonsson, Anne-Charlotte 1,2,3 Lindbi, Bo S. 1,2,3 Arne Lundbland 1,2,3; Affiliation: 1: National Cancer Institute and National Institute of Arthrus, Metabolism and Digestive Diseases National Institutes of Health, Bethesda, Maryland. 2: Department of Clinical Chemistry, University Hospital, Lund. 3: Department of Obstetrics and Gynecology, Central Hospital, Central Hospital, Vasteras.; Source Info: 2/1/79, Vol. 93 Issue 3, p431; Subject Term: EXAMINATION of the blood; Subject Term: OLIGOSACCHARIDES; Subject Term: EXCRETION; Subject Term: BLOOD transfusion; Subject Term: PHYSIOLOGY; Subject Term: BLOOD cells; Number of Pages: 5p; Document Type: Article
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ER -
TY - JOUR
AU - KABAT, ELVIN A.
T1 - Antibody Gene Structure.
JO - Science
JF - Science
Y1 - 1979/02/02/
VL - 203
IS - 4379
M3 - Article
SP - 400
EP - 400
SN - 00368075
N1 - Accession Number: 85268686; KABAT, ELVIN A. 1,2; Affiliations: 1: Departments of Microbiology, Human Genetics and Development, and Neurobiology, Columbia University, New York 10032; 2: National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1979, Vol. 203 Issue 4379, p400; Number of Pages: 1/3p; Document Type: Article
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ER -
TY - JOUR
AU - WOLPAW, JONATHAN R.
T1 - Electromagnetic Muscle Stretch Strongly Excites Sensorimotor Cortex Neurons in Behaving Primates.
JO - Science
JF - Science
Y1 - 1979/02/02/
VL - 203
IS - 4379
M3 - Article
SP - 465
EP - 467
SN - 00368075
AB - Responses of single units in primary motor and sensory cortex of behaving primates to electromagnetic stretch of the muscle flexor carpi ulnaris are comparable in latency and intensity to responses to wrist extension. Thus, muscle stretch appears to be a major factor in cortical response to limb displacement during performance and probably has an important role in motor control at the cortical level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268725; WOLPAW, JONATHAN R. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 2/ 2/1979, Vol. 203 Issue 4379, p465; Number of Pages: 3p; Document Type: Article
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TY - JOUR
AU - ENQUIST, L. W.
AU - MADDEN, M. J.
AU - SCHIOP-STANSLY, P.
AU - WOUDE, G. F. VANDE
T1 - Cloning of Herpes Simplex Type 1 DNA Fragments in a Bacteriophage Lambda Vector.
JO - Science
JF - Science
Y1 - 1979/02/09/
VL - 203
IS - 4380
M3 - Article
SP - 541
EP - 544
SN - 00368075
AB - DNA isolated from defective and nondefective virions of herpes simplex type I (HSV-J) (strain Patton) was digested with restriction endonucleases, and the resulting DNA fragments were inserted in the EK2 coliphage vector AgtWES XB. The recombinant DNA was encapsidated in vitro under P4 maximum containment conditions. These X-HSVI hybrids were purified and amplified, and the DNA was isolated in the P4 facility. DNA, free of viable phage and bacteria, was removed from P4 conditions and analyzed. Represented among the hybrids studied to date are DNA fragments from about 50 percent of the normal HSV-1 genome. The hybrids derived from defective HSV-I DNAfragments demonstrate the existence of many similar but not identical classes of defective genomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268760; ENQUIST, L. W. 1; MADDEN, M. J. 1; SCHIOP-STANSLY, P. 1; WOUDE, G. F. VANDE 1; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p541; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - HARRISON, LEN C.
AU - FLIER, JEFFREY
AU - ITIN, AHUVA
AU - KAHN, C. RONALD
AU - ROTH, JESSE
T1 - Radioimmunoassay of the Insulin Receptor: A New Probe of Receptor Structure and Function.
JO - Science
JF - Science
Y1 - 1979/02/09/
VL - 203
IS - 4380
M3 - Article
SP - 544
EP - 547
SN - 00368075
AB - A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lvmphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268761; HARRISON, LEN C. 1; FLIER, JEFFREY 1; ITIN, AHUVA 1; KAHN, C. RONALD 1; ROTH, JESSE 1; Affiliations: 1: Diabetes Branch, National Institute of Arthritis, Metabolism, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p544; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - DRISCOLL, BERNARD F.
AU - KIES, MARIAN W.
AU - ALVORD JR., ELLSWORTH C.
T1 - Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells.
JO - Science
JF - Science
Y1 - 1979/02/09/
VL - 203
IS - 4380
M3 - Article
SP - 547
EP - 548
SN - 00368075
AB - Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 107 cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268762; DRISCOLL, BERNARD F. 1; KIES, MARIAN W. 1; ALVORD JR., ELLSWORTH C. 2; Affiliations: 1: Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Neuropathology RJ-05, University of Washington, School of Medicine, Seattle 98195; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p547; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - WYATT, RICHARD G.
AU - MEBUS, CHARLES A.
AU - YOLKEN, ROBERT H.
AU - KALICA, ANTHONY R.
AU - JAMES JR., HARVEY D.
AU - KAPIKIAN, ALBERT Z.
AU - CHANOCK, ROBERT M.
T1 - Rotaviral Immunity in Gnotobiotic Calves: Heterologous Resistance to Human Virus Induced by Bovine Virus.
JO - Science
JF - Science
Y1 - 1979/02/09/
VL - 203
IS - 4380
M3 - Article
SP - 548
EP - 550
SN - 00368075
AB - The possibility of immunizing human infants against rotaviruses, which cause severe dehydrating diarrheal disease, may depend on the use of a related rotavirus, derived from another animal species, as a source of antigen. To test the feasibility of this approach, calves were infected in utero with a bovine rotavirus and challenged with bovine or human type 2 rotavirus shortly after birth. Infection in utero with bovine rotavirus induced resistance to diarrheal disease caused by the human virus as well as the homologous bovine virus. These data suggest that the bovine virus is sufficiently related antigenically to the human type 2 virus to warrant further evaluation of the former as a source of vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268763; WYATT, RICHARD G. 1; MEBUS, CHARLES A. 2; YOLKEN, ROBERT H. 3; KALICA, ANTHONY R. 3; JAMES JR., HARVEY D. 3; KAPIKIAN, ALBERT Z. 3; CHANOCK, ROBERT M. 3; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; 2: Plum Island Animal Disease Center, Greenport, New York 11944; 3: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p548; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - DE SERRES, FREDERICK J.
AU - SHELBY, MICHAEL D.
T1 - The Salmonella Mutagenicity Assay: Recommendations.
JO - Science
JF - Science
Y1 - 1979/02/09/
VL - 203
IS - 4380
M3 - Article
SP - 563
EP - 565
SN - 00368075
N1 - Accession Number: 85268770; DE SERRES, FREDERICK J. 1; SHELBY, MICHAEL D. 1; Affiliations: 1: Office of the Associate Director for Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: 2/ 9/1979, Vol. 203 Issue 4380, p563; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Pitha, Josef
AU - Kociolek, Karol
AU - Caron, Marc G.
T1 - Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/02/15/
VL - 94
IS - 1
M3 - Article
SP - 11
EP - 18
PB - Wiley-Blackwell
SN - 00142956
AB - Residues of Triton X-100 [C8H17-C6H4-(O-CH2-CH2)9-10-O-] were bound by ether bonds to inulin, dextran, amylose, and cellulose-yielding compounds containing 10- 30, 5, 19 and 6% (w/w) of Triton X-100 residue respectively. The water-soluble inulin derivative was studied in detail. This compound was fractionated on the basis of molecular weight by gel chromatography and on the basis of degree of substitution by adsorption to polystyrene resin. Even the residues of Triton X-100 which were bound to a single inulin macromolecule were able to form a micelle; in addition to these monomolecular micelles the inulin derivative was able to form polymolecular micelles as well. The inulin derivative was effective in solubilizing proteins and phospholipids from membranes of human erythrocytes and liberated reverse transcriptase activity from the membrane-enveloped virions of murine leukemia. The Triton X-100 inulin derivative abolished binding of the ³H-labelled antagonist dihydroalprenolol to solubilized preparations of β-adrenergic receptors from frog erythrocytes in a dose-related manner similar to the inactivation produced by Triton X-100, while digitonin, a detergent containing a bulkier hydrophobic group, did not cause inactivation. On the basis of its Triton X-100 content, the inulin derivative was found to be less detrimental to the growth of murine erythroleukemic cells in vitro than Triton X-100 alone when short (2-4 h) exposures were used, but this difference disappeared at longer (1-3 day) exposures. Results thus suggest that the increase in size of the hydrophilic part of the detergent brings about moderation in those effects of the detergent which are dependent on the rate of diffusion, while the solubilizing and inactivating effects of the detergent were not changed. It is probably the size of the hydrophobic part which is important in protein-inactivating properties of the detergent. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - CARBOHYDRATES
KW - LEUKEMIA
KW - CLEANING compounds
KW - PROTEINS
KW - CANCER
KW - LABELING
N1 - Accession Number: 13605068; Pitha, Josef 1 Kociolek, Karol 2 Caron, Marc G. 3; Affiliation: 1: Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland. 2: Baltimore City Hospitals, Baltimore, Maryland. 3: Department of Medicine, Duke University Medical Center, Durham, North Carolina.; Source Info: 2/15/79, Vol. 94 Issue 1, p11; Subject Term: POLYSACCHARIDES; Subject Term: CARBOHYDRATES; Subject Term: LEUKEMIA; Subject Term: CLEANING compounds; Subject Term: PROTEINS; Subject Term: CANCER; Subject Term: LABELING; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HOOPER, N. KIM
AU - HARRIS, ROBERT H.
AU - AMES, BRUCE N.
AU - SCHNEIDERMAN, MARVIN A.
AU - WEIGERT, FRANK J.
T1 - Chemical Carcinogens.
JO - Science
JF - Science
Y1 - 1979/02/16/
VL - 203
IS - 4381
M3 - Article
SP - 602
EP - 603
SN - 00368075
N1 - Accession Number: 85199289; HOOPER, N. KIM 1; HARRIS, ROBERT H. 1; AMES, BRUCE N. 1; SCHNEIDERMAN, MARVIN A. 2; WEIGERT, FRANK J.; Affiliations: 1: Department of Biochemistry, University of California, Berkeley 94720; 2: National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 2/16/1979, Vol. 203 Issue 4381, p602; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAION, ROSA MARIA
AU - KRISHNA, GOPAL
AU - IGNARRO, LOUIS J.
T1 - Cytidylate Cyclase: Possible Artifacts in the Methodology.
JO - Science
JF - Science
Y1 - 1979/02/16/
VL - 203
IS - 4381
M3 - Article
SP - 672
EP - 673
SN - 00368075
N1 - Accession Number: 85199323; GAION, ROSA MARIA 1; KRISHNA, GOPAL 1; IGNARRO, LOUIS J. 2; Affiliations: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112; Issue Info: 2/16/1979, Vol. 203 Issue 4381, p672; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MOORE, JOHN A.
T1 - A Pesticide.
JO - Science
JF - Science
Y1 - 1979/02/23/
VL - 203
IS - 4382
M3 - Article
SP - 741
EP - 742
SN - 00368075
N1 - Accession Number: 85199360; MOORE, JOHN A. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 2/23/1979, Vol. 203 Issue 4382, p741; Number of Pages: 2p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Hollenbeck, Albert R.
AU - Slaby, Ronald G.
T1 - Infant Visual and Vocal Responses to Television.
JO - Child Development
JF - Child Development
Y1 - 1979/03//
VL - 50
IS - 1
M3 - Article
SP - 41
EP - 45
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12432787; Hollenbeck, Albert R. 1 Slaby, Ronald G. 2; Affiliation: 1: National Institute of Mental Health 2: University of Washington; Source Info: Mar1979, Vol. 50 Issue 1, p41; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1467-8624.ep12432787
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Faith, R. E.
AU - Luster, M. I.
AU - Kimmel, Carole A.
T1 - Effect of chronic developmental lead exposure on cell- mediated immune functions.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/03//
VL - 35
IS - 3
M3 - Article
SP - 413
EP - 420
PB - Wiley-Blackwell
SN - 00099104
AB - Studies were performed to investigate the effects of chronic, low level pre- and post-natal lead exposure on cell-mediated immune function in rats. Weanling female rats were exposed to lead (as lead acetate) in their drinking water at 0, 25, and 50 ppm for 7 weeks. At the end of 7 weeks they were mated with untreated males and continued on the same dosage throughout gestation and lactation. The offspring of these females were weaned at 21 days of age and continued on the same lead exposure regimen as their mothers. These offspring were used in immune surveillance procedures between 35 and 45 days of age. Lead exposure at the levels employed had no statistically significant effect on growth anti did not result in overt signs of toxicity. Thymic weights were significantly decreased in both males and females of the two lead dosage groups. Furthermore, lead exposure resulted in suppression of responsiveness of lymphocytes to mitogen stimulation and in reduced delayed hypersensitivity responsiveness. Results indicate that chronic low-level lead exposure causes suppression of cell mediated immune function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC diseases
KW - IMMUNE system
KW - IMMUNOLOGIC diseases
KW - LEAD -- Toxicology
KW - LEUCOCYTES
KW - CELLULAR immunity
N1 - Accession Number: 15987750; Faith, R. E. 1 Luster, M. I. 1 Kimmel, Carole A. 1; Affiliation: 1: Environmental Biology and Chemistry Branch and Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences, USA.; Source Info: Mar1979, Vol. 35 Issue 3, p413; Subject Term: CHRONIC diseases; Subject Term: IMMUNE system; Subject Term: IMMUNOLOGIC diseases; Subject Term: LEAD -- Toxicology; Subject Term: LEUCOCYTES; Subject Term: CELLULAR immunity; Number of Pages: 8p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Nelson, D. L.
AU - Poplack, D. G.
AU - Holiman, Betty J.
AU - Henkart, P. A.
T1 - ADCC against human erythrocyte target cells: role of the anti-target cell antibodies in determining lymphocyte killer activity.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/03//
VL - 35
IS - 3
M3 - Article
SP - 447
EP - 453
PB - Wiley-Blackwell
SN - 00099104
AB - Studies were undertaken to investigate the role of anti-target cell antibodies in determining whether lymphocytes can mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro. Trinitrophenyl (TNP) modified Chang liver cells and human erythrocytes were employed as target cells and were coated with xenogeneic and allogeneic antibodies against TNP and natural cell surface antigens. Two cytotoxic effector cell populations were used: human peripheral blood mononuclear cells (PBMC) containing both lymphocytes and monocytes, and monocyte depleted peripheral blood lymphocytes (PBL). With Chang targets, both PBMC and PBL mediated ADCC with xenogeneic anti-Chang and xenogeneic anti-TNP sera. With human erythrocyte targets, PBMC but not PBL mediated ADCC with human anti-blood group B serum, while both PBMC and PBL mediated ADCC with xenogeneic anti-TNP sera and also with ;i human anti-CD serum. These results demonstrate that the source of anti-target cell antibodies employed in ADCC reactions may determine whether or not lymphocytes are capable of mediating cytotoxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROCYTES
KW - LEUCOCYTES
KW - BLOOD cells
KW - IMMUNOGLOBULINS
KW - LYMPHOCYTES
KW - KILLER cells
N1 - Accession Number: 15987899; Nelson, D. L. 1 Poplack, D. G. 1 Holiman, Betty J. 1 Henkart, P. A. 1; Affiliation: 1: Metabolism, Pediatric Oncology and Immunology Branches of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.; Source Info: Mar1979, Vol. 35 Issue 3, p447; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Subject Term: BLOOD cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: KILLER cells; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grummt, Ingrid
AU - Hall, Stanton H.
AU - Crouch, Robert J.
T1 - Localisation of an Endonuclease Specific for Double-Stranded RNA within the Nucleolus and Its Implication in Processing Ribosomal Transcripts.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/03//3/1/79
VL - 94
IS - 2
M3 - Article
SP - 437
EP - 443
PB - Wiley-Blackwell
SN - 00142956
AB - Nucleoli of both chick embryos and mouse Ehrlich ascites cells contain an enzymatic activity that is very similar to RNase DII, an enzyme isolated from total chick embryos for its ability to degrade double-stranded RNA. The enzyme can be extracted by low salt/EDTA from nucleoli and is associated with pre-ribosomal 80-S and 55-S particles. Under ionic conditions which are inhibitory for the nucleolytic activity the transcript in vitro of nucleoli is not processed and sediments around 45 S. Under salt conditions which are optimal for the nucleolar enzyme the nucleolar transcripts are cleaved to distinct intermediate-sized molecules. Addition of the chicken RNase DII or RNase III to the nucleolar transcription system results in a similar shift of the chain length of the RNA molecules. It is concluded that a nucleolar RNase recognizing double-stranded regions in the pre-ribosomal RNA is involved in the maturation of ribosomal RNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDONUCLEASES
KW - RNA
KW - NUCLEOLUS
KW - RIBOSOMES
KW - GENETIC transcription
KW - BIOCHEMISTRY
N1 - Accession Number: 13607257; Grummt, Ingrid 1 Hall, Stanton H. 1 Crouch, Robert J. 1; Affiliation: 1: Max-Planck-Institut für Biochemie, Martinsried bei Münchem, and Section on Molecular Regulation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/79, Vol. 94 Issue 2, p437; Subject Term: ENDONUCLEASES; Subject Term: RNA; Subject Term: NUCLEOLUS; Subject Term: RIBOSOMES; Subject Term: GENETIC transcription; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams Jr., Redford B.
AU - Eichelman, Burr S.
AU - Ng, L. K. Y.
T1 - The Effects of Peripheral Chemosympathectomy and Adrenalectomy Upon Blood Pressure Responses of the Rat to Footshock Under Varying Conditions: Evidence for Behavioral Effects on Patterning of Sympathetic Nervous System Responses.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1979/03//
VL - 16
IS - 2
M3 - Article
SP - 89
EP - 93
SN - 00485772
AB - A significant decrease in blood pressure is observed after shock-induced fighting in intact rats. In rats treated with intravenous 6-hydroxydopamine, a drug that selectively destroys peripheral sympathetic nerve endings when given by this route, this blood pressure response is reversed to a significant increase. In contrast, adrenalectomy converts a slight increase in blood pressure after intact rats are shocked alone in the cage into a significant decrease. These alterations in blood pressure response suggest that the sympathetic response to a stressful stimulus is not an all or none response, but, rather, consists of a patterned activation depending upon the behavioral response available. The current physiological findings are consistent with neuroendocrine research in which coping behavior is found associated with a predominant norepinephrine release by the sympathetic nervous system, and stress without available coping responses is associated with release also of epinephrine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SHOCK (Mechanics)
KW - BLOOD pressure
KW - SYMPATHETIC nervous system
KW - HYDROXYL group
KW - DOPAMINE
KW - ADRENALECTOMY
KW - STRESS (Psychology)
KW - NORADRENALINE
KW - ADRENALINE
KW - RATS
KW - 6-hydroxydopamine
KW - adrenalectomy
KW - blood pressure response
KW - coping
KW - shock-induced fighting
KW - sympathetic nervous system
N1 - Accession Number: 11192076; Williams Jr., Redford B. 1 Eichelman, Burr S. 1 Ng, L. K. Y. 1; Affiliation: 1: Laboratory of Clinical Psychobiology, National Institute of Mental Health.; Source Info: Mar1979, Vol. 16 Issue 2, p89; Subject Term: SHOCK (Mechanics); Subject Term: BLOOD pressure; Subject Term: SYMPATHETIC nervous system; Subject Term: HYDROXYL group; Subject Term: DOPAMINE; Subject Term: ADRENALECTOMY; Subject Term: STRESS (Psychology); Subject Term: NORADRENALINE; Subject Term: ADRENALINE; Subject Term: RATS; Author-Supplied Keyword: 6-hydroxydopamine; Author-Supplied Keyword: adrenalectomy; Author-Supplied Keyword: blood pressure response; Author-Supplied Keyword: coping; Author-Supplied Keyword: shock-induced fighting; Author-Supplied Keyword: sympathetic nervous system; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1469-8986.ep11192076
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ISRAEL, MARK A.
AU - CHAN, HARDY W.
AU - ROWE, WALLACE P.
AU - MARTIN, MALCOLM A.
T1 - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Plasmid Vector System.
JO - Science
JF - Science
Y1 - 1979/03/02/
VL - 203
IS - 4383
M3 - Article
SP - 883
EP - 887
SN - 00368075
AB - A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268797; ISRAEL, MARK A. 1; CHAN, HARDY W. 1; ROWE, WALLACE P. 2; MARTIN, MALCOLM A. 3; Affiliations: 1: DNA Recombinant Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases; 3: DNA Recombinant Research Unit; Issue Info: 3/ 2/1979, Vol. 203 Issue 4383, p883; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHAN, HARDY W.
AU - ISRAEL, MARK A.
AU - GARON, CLAUDE F.
AU - ROWE, WALLACE P.
AU - MARTIN, MALCOLM A.
T1 - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Lambda Phage Vector System.
JO - Science
JF - Science
Y1 - 1979/03/02/
VL - 203
IS - 4383
M3 - Article
SP - 887
EP - 892
SN - 00368075
AB - The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268798; CHAN, HARDY W. 1; ISRAEL, MARK A. 1; GARON, CLAUDE F. 2; ROWE, WALLACE P. 3; MARTIN, MALCOLM A. 4; Affiliations: 1: DNA Recombinant Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; 2: Laboratory of the Biology of Viruses; 3: Laboratory of Viral Diseases; 4: DNA Recombinant Research Unit; Issue Info: 3/ 2/1979, Vol. 203 Issue 4383, p887; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GRACELY, RICHARD H.
AU - DUBNER, RONALD
AU - MCGRATH, PATRICIA A.
T1 - Narcotic Analgesia: Fentanyl Reduces the Intensity but Not the Unpleasantness of Painful Tooth Pulp Sensations.
JO - Science
JF - Science
Y1 - 1979/03/23/
VL - 203
IS - 4386
M3 - Article
SP - 1261
EP - 1263
SN - 00368075
AB - Forty subjects rated the magnitude of painful electrical stimulation of tooth pulp before and after the intravenous administration of either fentanyl, a shortacting narcotic, or a saline placebo. The responses were choices of verbal descriptors from randomized lists of either sensory intensity (that is, weak, mild, intense) or unpleasantness (annoying, unpleasant, distressing) descriptors. The fentanyl significantly reduced the sensory intensity without reducing the unpleasantness of the tooth pulp stimuli, indicating that the mechanisms of narcotic analgesia may include a significant attenuation in pain sensation in addition to effects on pain reaction. These results stress the importance of using multiple measures of pain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199532; GRACELY, RICHARD H. 1; DUBNER, RONALD 1; MCGRATH, PATRICIA A. 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/23/1979, Vol. 203 Issue 4386, p1261; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STETTEN JR., DEWITT
T1 - Microbial Containment.
JO - Science
JF - Science
Y1 - 1979/03/30/
VL - 203
IS - 4387
M3 - Article
SP - 1292
EP - 1292
SN - 00368075
N1 - Accession Number: 85199544; STETTEN JR., DEWITT 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 3/30/1979, Vol. 203 Issue 4387, p1292; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WATERS, HAROLD
AU - JAFFE, LIONEL F.
T1 - Grants: The Time Factor.
JO - Science
JF - Science
Y1 - 1979/03/30/
VL - 203
IS - 4387
M3 - Article
SP - 1292
EP - 1292
SN - 00368075
N1 - Accession Number: 85199545; WATERS, HAROLD 1; JAFFE, LIONEL F. 2; Affiliations: 1: Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907; Issue Info: 3/30/1979, Vol. 203 Issue 4387, p1292; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Southwick, Charles H.
AU - Blood, Benjamin D.
T1 - Conservation and Management of Wild Primate Populations.
JO - BioScience
JF - BioScience
Y1 - 1979/04//
VL - 29
IS - 4
M3 - Article
SP - 233
EP - 237
SN - 00063568
AB - The article presents information on the conservation and management of wild primate populations. It raises concerns over the rapid depletion of primates and mentions about their importance in the natural and cultural heritage of nations; in understanding human behavior, ecology, and evolution; and in solving problems of human health and disease. Manpower development provides training in primate ecology and management at both the scientific/professional and paraprofessional levels. It talks about primate conservation programs and obstacles to the conservation of ecosystems.
KW - Zoogeography
KW - Wildlife conservation
KW - Ecosystem health
KW - Biotic communities
KW - Wildlife management
KW - Wildlife management areas
KW - Ecology
KW - Primates
KW - Animal population density
N1 - Accession Number: 28050835; Southwick, Charles H. 1,2; Blood, Benjamin D. 1,2; Affiliations: 1 : School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205; 2 : Interagency Primate Steering Committee, National Institutes of Health, Bethesda, MD 20014; Source Info: Apr1979, Vol. 29 Issue 4, p233; Thesaurus Term: Zoogeography; Thesaurus Term: Wildlife conservation; Thesaurus Term: Ecosystem health; Thesaurus Term: Biotic communities; Thesaurus Term: Wildlife management; Thesaurus Term: Wildlife management areas; Thesaurus Term: Ecology; Subject Term: Primates; Subject Term: Animal population density; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4154
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Moses, Regina M.
AU - Steinberg, Susan
T1 - Does the MA-1 respirator make you nervous?
JO - RN
JF - RN
Y1 - 1979/04//
VL - 42
IS - 4
M3 - Article
SP - 34
EP - 44
SN - 00337021
AB - Provides information on MA-1 respirator, a positive pressure volume ventilator. Categories of the indications for respiratory support; Conditions that affect the musculoskeletal system; Information on MA-1 works; Functions of the controls and alarms in the MA-1 respirator; Impact of mechanical ventilation on cardiovascular function. INSETS: How mechanical ventilation affects the body: Some problems to;I saw the MA-1 through a patient's eyes--my own.
KW - RESPIRATORS (Medical equipment)
KW - MEDICAL equipment
KW - RESPIRATORY therapy -- Equipment & supplies
N1 - Accession Number: 4882487; Moses, Regina M. 1; Steinberg, Susan 2; Source Information: Apr79, Vol. 42 Issue 4, p34; Subject: RESPIRATORS (Medical equipment); Subject: MEDICAL equipment; Subject: RESPIRATORY therapy -- Equipment & supplies; Number of Pages: 12p; Illustrations: 2 Black and White Photographs, 2 Diagrams; Document Type: Article; Full Text Word Count: 6232
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Loeb, Gerald E.
T1 - LETTER.
JO - Scientific American
JF - Scientific American
Y1 - 1979/04//
VL - 240
IS - 4
M3 - Letter
SP - 10
EP - 10
SN - 00368733
AB - A letter to the editor is presented in response to the article "The Coupled Motions of Piano Strings," by Gabriel Weinreich in the January 1979 issue.
KW - Letters to the editor
KW - Weinreich, Gabriel
N1 - Accession Number: 20097144; Loeb, Gerald E. 1; Affiliations: 1: Laboratory of Neural Control National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, U.S. Public Health Service, Department of Health, Education and Welfare Bethesda, Md.; Issue Info: Apr79, Vol. 240 Issue 4, p10; Subject Term: Letters to the editor; People: Weinreich, Gabriel; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2005-09247-001
AN - 2005-09247-001
AU - Shah, Saleem A.
T1 - Professionals and the Community: Some Considerations of Public Policy and Professional Parochiality.
JF - Professional Psychology
JO - Professional Psychology
JA - Prof Psychol
Y1 - 1979/04//
VL - 10
IS - 2
SP - 133
EP - 134
CY - US
PB - American Psychological Association
SN - 0033-0175
N1 - Accession Number: 2005-09247-001. Other Journal Title: Professional Psychology: Research and Practice. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Center for Studies of Crime and Delinquency, US. Release Date: 20060327. Correction Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Psychology; Social Influences; Interpersonal Control. Minor Descriptor: Professional Personnel; Professional Standards. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Apr, 1979. Copyright Statement: American Psychological Association. 1979.
AB - This article focuses on occupational groups that have succeeded in attaining the status of professions, as this term has been used by sociologists. The privilege and power that increasingly are exercised by major professional groups raise important questions about how these influences affect the interests and welfare of the general public. The point being emphasized here is simply that the values, ideologies, and policies espoused by professional and other special interest groups cannot be equated with, nor can they be viewed as necessarily synonymous or even consistent with, the public interest. It was asserted that clinical psychologists while pointing to the arrogance of other professions have shown a 'me-tooism' regarding the power and privilege enjoyed by colleagues in medicine and psychiatry. The author suggests that psychology learn from recent history related to issues of social accountability that have been raised in relation to other powerful professions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public policy
KW - professional & occupational groups
KW - special interest groups
KW - social influence
KW - values
KW - ideologies
KW - psychology
KW - medical profession
KW - 1979
KW - Psychology
KW - Social Influences
KW - Interpersonal Control
KW - Professional Personnel
KW - Professional Standards
KW - 1979
DO - 10.1037/h0078168
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-43131-006
AN - 2013-43131-006
AU - Shore, Milton F.
AU - Massimo, Joseph L.
T1 - Fifteen years after treatment: A follow-up study of comprehensive vocationally-oriented psychotherapy.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1979/04//
VL - 49
IS - 2
SP - 240
EP - 245
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-43131-006. PMID: 434118 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Male Delinquency; Psychotherapy; Remedial Education; Vocational Rehabilitation. Minor Descriptor: Adjustment; Personnel Placement. Classification: Criminal Behavior & Juvenile Delinquency (3236); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Interview; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 1979. Copyright Statement: American Orthopsychiatric Association, Inc. 1979.
AB - The fourth follow-up study of adolescent delinquent boys treated in a community-based program that combined job placement, remedial education, and psychotherapy indicates that the better overall adjustment of the treated group, compared to untreated controls, is maintained well into adulthood. It reaffirms the importance of developing sound, innovative means of reaching adolescents in crisis, and suggests the value of a full-scale replication of the original program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vocationally oriented psychotherapy
KW - delinquent boys
KW - remedial education
KW - job placement
KW - adjustment
KW - 1979
KW - Male Delinquency
KW - Psychotherapy
KW - Remedial Education
KW - Vocational Rehabilitation
KW - Adjustment
KW - Personnel Placement
KW - 1979
DO - 10.1111/j.1939-0025.1979.tb02605.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - POLLIN, WILLIAM
T1 - Pert and the Lasker Award.
JO - Science
JF - Science
Y1 - 1979/04/06/
VL - 204
IS - 4388
M3 - Article
SP - 8
EP - 8
SN - 00368075
N1 - Accession Number: 85199595; POLLIN, WILLIAM 1; Affiliations: 1: Office, Director, Division of Research, National Institute on Drug Abuse, Rockville, Maryland 208S7; Issue Info: 4/ 6/1979, Vol. 204 Issue 4388, p8; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOZAK, CHRISTINE A.
AU - ROWE, WALLACE P.
T1 - Genetic Mapping of the Ecotropic Murine Leukemia Virus-Inducing Locus of BALB/c Mouse to Chromosome 5.
JO - Science
JF - Science
Y1 - 1979/04/06/
VL - 204
IS - 4388
M3 - Article
SP - 69
EP - 71
SN - 00368075
AB - By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALBIc mice, was mapped to chromosome 5, 23 units from the locusforphosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199629; KOZAK, CHRISTINE A. 1; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/ 6/1979, Vol. 204 Issue 4388, p69; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOONE, CHARLES W.
AU - TAKEICHI, NORITOSHI
AU - EATON, SOL DEL ANDE
AU - PARANJPE, MEERA
T1 - "Spontaneous" Neoplastic Transformation in vitro: A Form of Foreign Body (Smooth Surface) Tumorigenesis.
JO - Science
JF - Science
Y1 - 1979/04/13/
VL - 204
IS - 4389
M3 - Article
SP - 177
EP - 179
SN - 00368075
AB - Explants of subcutaneous connective tissue from adult BALBIc mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate(2.4 × 104 to 3.4 × 105 cells per plate)formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did notform tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1l/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smoothsurfaced foreign bodies, regardless of theirchemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogenfirst in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199683; BOONE, CHARLES W. 1; TAKEICHI, NORITOSHI 1; EATON, SOL DEL ANDE 1; PARANJPE, MEERA 1; Affiliations: 1: Cell Biology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p177; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FILIPSKI, JAN
AU - KOHN, KURT W.
AU - PRATHER, RICHARD
AU - BONNER, WILLIAM M.
T1 - Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II).
JO - Science
JF - Science
Y1 - 1979/04/13/
VL - 204
IS - 4389
M3 - Article
SP - 181
EP - 183
SN - 00368075
AB - Cis and trans dichlorodiaminoplatinum(JI) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt(IJ) treatment of λ DNA decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated λDNA can be restored. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199685; FILIPSKI, JAN 1; KOHN, KURT W. 1; PRATHER, RICHARD 1; BONNER, WILLIAM M. 1; Affiliations: 1: Laboratory of Molećular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p181; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSTEIN, J. N.
AU - MAGIN, R. L.
AU - YATVIN, M. B.
AU - ZAHARKO, D. S.
T1 - Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors.
JO - Science
JF - Science
Y1 - 1979/04/13/
VL - 204
IS - 4389
M3 - Article
SP - 188
EP - 191
SN - 00368075
AB - Liposomnes with phase transitions a few! degrees above physiological temperatuire delivered more than four times as much mnethotrexate to murine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reduc tase, the enzyme blocked by mnethotrexate in its role as an antineoplastic agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199689; WEINSTEIN, J. N. 1; MAGIN, R. L. 2; YATVIN, M. B. 3; ZAHARKO, D. S. 2; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 2: Laboratory of Chemical Pharmacology, Division of Cancer Treatment, National Cancer Institute; 3: Radiobiology Research Laboratory, Department of Human Oncology, University of Wisconsin, Madison 53706; Issue Info: 4/13/1979, Vol. 204 Issue 4389, p188; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huan, Kuo-Ping
T1 - Regulation of Glycogen Synthase Activity in Choriocarcinoma Cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/04/17/
VL - 95
IS - 3
M3 - Article
SP - 477
EP - 485
PB - Wiley-Blackwell
SN - 00142956
AB - Choriocarcinoma cell glycogen synthase exists predominantly in the form dependent on glucose- 6-phosphate during growth. This enzyme can not be converted to the form independent of glucose 6-phosphate by endogenous phosphoprotein phosphatase, rabbit liver phosphoprotein phosphatase, or human placental alkaline phosphatase. However, the glycogen synthase present in the extract of cells which have been subjected to glucose starvation for 24 h can be converted to the form independent of glucose 6-phosphate by these phosphatases. The activity which converts the form dependent on glucose 6-phosphate to the form independent of glucose 6-phosphate by the endogenous phosphatase is progressively increased during starvation. This increase in activity is blocked by the presence of 20 μM cycloheximide in the medium. Analysis of the kinetic properties of glycogen synthase isolated from cells during starvation shows that the A0.5 value (the activator concentration giving 50 % maximal activity) for glucose 6-phosphate and the Sos value (the substrate concentration giving 50 % maximum activity) for UDP-glucose are reduced. This reduction in the kinetic constants of the enzyme is also prevented by the presence of cycloheximide. The starvation- induced change in the kinetic properties of the enzyme can be reversed by the incubation of the starved-cell extract with ATP, Mg2+, and cyclic AMP or by refeeding the starved cells with medium containing high glucose. Also, the glycogen synthase which has similar kinetic properties to the enzyme found in the starved cells can be derived from the enzyme present in normal cultures. This involves mixing a small portion of the starved cell extract with a large portion of normal cellular extract and incubating under conditions favoring dephosphorylation. It appears that during glucose starvation glycogen synthase is partially dephosphorylated, and the resulting enzyme, still in a form dependent on glucose 6-phosphate, has a lower A0.5 value for glucose 6-phosphate and a lower S0.5 value for UDP-glucose than the enzyme from cells without starvation. The starvation- induced modification of the form of the enzyme dependent on glucose 6-phosphate transforms it into a better substrate for phosphoprotein phosphatase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOGEN
KW - CHORIOCARCINOMA
KW - GLYCOGEN storage disease
KW - MONOSACCHARIDES
KW - CELLS
KW - PHOSPHOPROTEIN phosphatases
N1 - Accession Number: 13615857; Huan, Kuo-Ping 1; Affiliation: 1: Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland.; Source Info: 4/17/79, Vol. 95 Issue 3, p477; Subject Term: GLYCOGEN; Subject Term: CHORIOCARCINOMA; Subject Term: GLYCOGEN storage disease; Subject Term: MONOSACCHARIDES; Subject Term: CELLS; Subject Term: PHOSPHOPROTEIN phosphatases; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ANDERSEN, PHILIP R.
AU - BARBACID, MARIANO
AU - TRONICK, STEVEN R.
AU - CLARK, H. FRED
AU - AARONSON, STUART A.
T1 - Evolutionary Relatedness of Viper and Primate Endogenous Retroviruses.
JO - Science
JF - Science
Y1 - 1979/04/20/
VL - 204
IS - 4390
M3 - Article
SP - 318
EP - 321
SN - 00368075
AB - A retrovirus previously isolated from a tumored Russell's viper is shown by molecular hybridization to be an endogenous virus of this reptilian species. Radioimmunologic techniques revealed that the viper retrovirus is immunologically and, hence, evolutionarily related to endogenous type D retroviruses of Old World primates. These findings extend the number of vertebrate classes possessing endogenous retroviruses and suggest that type D retroviruses may even be more widely distributed in nature than type C retroviruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199745; ANDERSEN, PHILIP R. 1; BARBACID, MARIANO 1; TRONICK, STEVEN R. 1; CLARK, H. FRED 2; AARONSON, STUART A. 3; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute; Issue Info: 4/20/1979, Vol. 204 Issue 4390, p318; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HEFETZ, ABRAHAM
AU - FALES, HENRY M.
AU - BATRA, SUZANNE W. T.
T1 - Natural Polyesters: Dufour's Gland Macrocyclic Lactones Form Brood CeU Laminesters in CoUetes Bees.
JO - Science
JF - Science
Y1 - 1979/04/27/
VL - 204
IS - 4391
M3 - Article
SP - 415
EP - 417
SN - 00368075
AB - Bees in the genus Colletes make their brood cells in the ground and coat them with a highly resistant, waterproof, transparent membrane. This membrane is a polyester constructed maifiiY from 18-hydroxyoctadecanoic acid and 20-hydroxyeicosanoic acid, which are stored as their corresponding lactones in the Dufour's gland of the bee. When lining the cells, the bee secretes its glandular content, and the membrane is apparently a product of polycondensation reaction 'of its contents. This appears to be the first report of a naturally occurring linear polyester. The term laminester (lamina =layer + ester) for this class of compounds is proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85199790; HEFETZ, ABRAHAM 1; FALES, HENRY M. 1; BATRA, SUZANNE W. T. 2; Affiliations: 1: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Beneficial Insect Introduction Laboratory, Insect Identification and Beneficial Insect Introduction Institute, Science and Education Administration, Department of Agriculture, Beltsville, Maryland 20705; Issue Info: 4/27/1979, Vol. 204 Issue 4391, p415; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Blair, Aaron
AU - Decoufle, Pierre
AU - Grauman, Dan
T1 - Causes of Death among Laundry and Dry Cleaning Workers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/05//
VL - 69
IS - 5
M3 - Article
SP - 508
EP - 511
PB - American Public Health Association
SN - 00900036
AB - The article discusses the study that compared the specific causes of death in a small group of former laundry and dry cleaning workers against the experience of the general population in the U.S. During the data collection phase of the study, researchers obtained a limited set of mortality records for the period 1957-1977 from two union groups, the Laundry, Dry Cleaning and the Dye House Workers' International Union. In the study, the increased proportion of cancer deaths among laundry and dry cleaning workers suggest an elevated risk resulting from exposure to dry cleaning fluids.
KW - OCCUPATIONAL mortality
KW - MORTALITY -- Statistics
KW - LAUNDRY workers
KW - SERVICE industries workers
KW - HAZARDOUS substances -- Health aspects
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - DRY cleaning industry
KW - LAUNDRY industry
KW - UNITED States
N1 - Accession Number: 6005867; Blair, Aaron 1 Decoufle, Pierre 1 Grauman, Dan 1; Affiliation: 1: Environmental Epidemiology Branch, National Lancer Institute, National Institutes of Health, Bethesda, MD 20014; Source Info: May79, Vol. 69 Issue 5, p508; Subject Term: OCCUPATIONAL mortality; Subject Term: MORTALITY -- Statistics; Subject Term: LAUNDRY workers; Subject Term: SERVICE industries workers; Subject Term: HAZARDOUS substances -- Health aspects; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: DRY cleaning industry; Subject Term: LAUNDRY industry; Subject Term: UNITED States; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 812331 Linen Supply; NAICS/Industry Codes: 812332 Industrial Launderers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garwood, Marcia K.
AU - Engel, Bernard T.
AU - Quilter, Reginald E.
T1 - Age Differences in the Effect of Epidermal Hydration on Electrodermal Activity.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1979/05//
VL - 16
IS - 3
M3 - Article
SP - 311
EP - 317
SN - 00485772
AB - The effect of epidermal hydration on skin potential and conductance measurements was investigated in young and old men. The condition of least hydration used a 0.5% KCI glycol electrolyte. Two conditions used a 0.5% aqueous KCI electrolyte differing in that the most hydrated site received a 15-min pretreatment of soaking in distilled water whereas the intermediate hydration site received no pretreatment. These hydration conditions were used in recording three channels of skin potential and three channels of skin conductance during three tasks: 1) tone presentations after rest, 2) simple reaction time, and 3) choice reaction time. There were no significant age differences in the effect of electrolyte on skin conductance level and response. There were age differences in the effect of electrolyte on skin potential level (SPL) and response (SPR). Young adult SPR was monotonically related to hydration with the largest response magnitude occurring with the least hydration. Electrolyte did not significantly affect SPR magnitude of the aged. For the young subjects, SPL was monotonically related to hydration with the most negative SPL occurring with the least hydration. For the aged subjects, the least negative SPL occurred in the condition of least hydration. We postulate that this reversal in the hydration/SPL relationship in old age reflects a reversal in the relative magnitudes of sweat gland and epidermal potentials: in old subjects the epidermal potential is greater than the sweat gland potential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GALVANIC skin response
KW - HYDRATION
KW - AGING
KW - REACTION time
KW - ELECTROLYTES
KW - SWEAT glands
KW - Aging
KW - Hydration
KW - Skin conductance
KW - Skin potential.
N1 - Accession Number: 11195382; Garwood, Marcia K. 1 Engel, Bernard T. 2 Quilter, Reginald E. 3; Affiliation: 1: Gerontology Research Center (Baltimore) National Institute on Aging National Institutes of Health PHS. 2: U.S. Department of Health Education and Welfare Bethesda. 3: Baltimore City Hospitals Baltimore.; Source Info: May1979, Vol. 16 Issue 3, p311; Subject Term: GALVANIC skin response; Subject Term: HYDRATION; Subject Term: AGING; Subject Term: REACTION time; Subject Term: ELECTROLYTES; Subject Term: SWEAT glands; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Hydration; Author-Supplied Keyword: Skin conductance; Author-Supplied Keyword: Skin potential.; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1469-8986.ep11195382
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Borgatta, Edgar F.
AU - Jackson, David J.
T1 - AGGREGATE DATA ANALYSIS.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1979/05//
VL - 7
IS - 4
M3 - Article
SP - 379
SN - 00491241
AB - This article discusses various issues related to aggregate data analysis, with particular emphasis on the nature of measurement for aggregated data. With the wisdom of hindsight, more recent generations have been able to look back and see the methodological errors of the past in interpretation of aggregated data, and at this juncture, the questions surrounding the use of aggregated data are becoming systematized. The issues that are raised in dealing with aggregated data proceed on to many questions that involve assumptions about the concepts that are used, metric, and so forth. Aside from the complexity of process that is implied in some of the arbitrary procedures of aggregating data, sometimes the concept that is involved is not represented well by the operations involved in the creation of the measure. For example, the idea of city size may suggest many alternative measures, but for most it will conjure up an image of the metropolis as compared to a small town or city. City size is usually thought of in terms of the population size, the number of people within the geographical boundary. Population size is only one indication of size, and intrinsically one may be suggesting the concentration, density, with the concept rather than the total count.
KW - SOCIOLOGY -- Methodology
KW - DATA analysis
KW - QUANTITATIVE research
KW - STATISTICAL reliability
KW - INFORMATION retrieval
KW - SOCIOLOGICAL research
N1 - Accession Number: 5863258; Borgatta, Edgar F. 1; Jackson, David J. 2; Source Information: May79, Vol. 7 Issue 4, p379; Subject: SOCIOLOGY -- Methodology; Subject: DATA analysis; Subject: QUANTITATIVE research; Subject: STATISTICAL reliability; Subject: INFORMATION retrieval; Subject: SOCIOLOGICAL research; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2006-06574-037
AN - 2006-06574-037
AU - Yarrow, Leon J.
T1 - Counsel for Counselors.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1979/05//
VL - 24
IS - 5
SP - 399
EP - 401
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06574-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Social and Behavioral Sciences Branch, National Institute of Child Health and Human Development (NIH), US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Counselors; Parental Role; Parents. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Arnold, L. Eugene (Ed). Helping Parents Help Their Children=New York: Brunner/Mazel, 1978. Pp. xv + 420. $17.50; 1978. Page Count: 3. Issue Publication Date: May, 1979.
AB - Reviews the book, Helping Parents Help Their Children edited by L. Eugene Arnold (1978). The objectives of this book are succinctly stated in the title; it is addressed to counselors of parents. In an excellent opening chapter, general principles of parental guidance are presented by the editor. The second section of this volume consists of a series of short chapters, each on a conceptual approach to parental guidance. The third section considers parents and children with specific problems: mentally and physically handicapped children, delinquent children, hyperactive children, and autistic and neurotic children. On the whole, each presentation is tight, most are clearly written, and many are insight provoking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental guidance
KW - counselors
KW - parents
KW - Childhood development
KW - 1979
KW - Childhood Development
KW - Counselors
KW - Parental Role
KW - Parents
KW - 1979
U2 - Arnold, L. Eugene (Ed). (1978); Helping Parents Help Their Children; New York: Brunner/Mazel, 1978. Pp. xv + 420. $17.50
DO - 10.1037/019015
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LOVENBERG, W.
AU - LEVINE, R. A.
AU - ROBINSON, D. S.
AU - EBERT, M.
AU - WILLIAMS, A. C.
AU - CALNE, D. B.
T1 - Hydroxylase Cofactor Activity in Cerebrospinal Fluid of Normal Subjects and Patients with Parkinson's Disease.
JO - Science
JF - Science
Y1 - 1979/05/11/
VL - 204
IS - 4393
M3 - Article
SP - 624
EP - 626
SN - 00368075
AB - A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrospinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268844; LOVENBERG, W. 1; LEVINE, R. A. 1; ROBINSON, D. S. 1; EBERT, M. 2; WILLIAMS, A. C. 3; CALNE, D. B. 3; Affiliations: 1: Section on Biochemical Pharmacology, Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20014; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Experimental Therapeutics Branch, IRP, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; Issue Info: 5/11/1979, Vol. 204 Issue 4393, p624; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PERLOW, MARK J.
AU - FREED, WILLIAM J.
AU - HOFFER, BARRY J.
AU - SEIGER, AKE
AU - OLSON, LARS
AU - WYATT, RICHARD JED
T1 - Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System.
JO - Science
JF - Science
Y1 - 1979/05/11/
VL - 204
IS - 4393
M3 - Article
SP - 643
EP - 647
SN - 00368075
AB - In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268853; PERLOW, MARK J. 1; FREED, WILLIAM J. 1; HOFFER, BARRY J. 2; SEIGER, AKE 3; OLSON, LARS 3; WYATT, RICHARD JED 4; Affiliations: 1: Unit on Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pharmacology, University of Colorado School of Medicine, Denver 80262; 3: Department of Histology, Karolinska Institute, Stockholm, Sweden; 4: Unit on Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital; Issue Info: 5/11/1979, Vol. 204 Issue 4393, p643; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GART, JOHN J.
AU - SCHNEIDERMAN, MARVIN A.
AU - GORI, GIO B.
T1 - "Low-Risk" Cigarettes: The Debate Continues.
JO - Science
JF - Science
Y1 - 1979/05/18/
VL - 204
IS - 4394
M3 - Article
SP - 688
EP - 692
SN - 00368075
N1 - Accession Number: 85195484; GART, JOHN J.; SCHNEIDERMAN, MARVIN A.; GORI, GIO B. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/18/1979, Vol. 204 Issue 4394, p688; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zahn-Waxler, Carolyn
AU - Radke-Yarrow, Marian
AU - King, Robert A.
T1 - Child Rearing and Children's Prosocial Initiations toward Victims of Distress.
JO - Child Development
JF - Child Development
Y1 - 1979/06//
VL - 50
IS - 2
M3 - Article
SP - 319
EP - 330
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12421504; Zahn-Waxler, Carolyn 1 Radke-Yarrow, Marian 1 King, Robert A. 2; Affiliation: 1: National Institute of Mental Health 2: Children's Hospital, Washington, D.C.; Source Info: Jun1979, Vol. 50 Issue 2, p319; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1467-8624.ep12421504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12421504&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gladen, Beth
T1 - The Use of the Jackknife to Estimate Proportions From Toxicological Data in the Presence of Litter Effects.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1979/06//Jun79 Part 1
VL - 74
IS - 366
M3 - Article
SP - 278
SN - 01621459
AB - The jackknifing methodology is proposed as a way of estimating and comparing proportions of affected fetuses in animal experiments. The estimate is a weighted average of the proportions in individual litters and is almost fully efficient in several cases of interest. The associated standard error is asymptotically correct for a wide range of possible models. Jackknife-based tests are shown to be competitive with other methods currently used. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - STATISTICS
KW - JACKKNIFE (Statistics)
KW - RESAMPLING (Statistics)
KW - TERATOLOGY
KW - SCIENTIFIC experimentation
KW - ABNORMALITIES in animals
KW - Beta-binomial
KW - Chi-squared tests
KW - Teratology.
N1 - Accession Number: 4609103; Gladen, Beth 1; Affiliations: 1: Staff Fellow, Biometry Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Jun79 Part 1, Vol. 74 Issue 366, p278; Thesaurus Term: ESTIMATION theory; Thesaurus Term: STATISTICS; Subject Term: JACKKNIFE (Statistics); Subject Term: RESAMPLING (Statistics); Subject Term: TERATOLOGY; Subject Term: SCIENTIFIC experimentation; Subject Term: ABNORMALITIES in animals; Author-Supplied Keyword: Beta-binomial; Author-Supplied Keyword: Chi-squared tests; Author-Supplied Keyword: Teratology.; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2004-20774-006
AN - 2004-20774-006
AU - Trela, James E.
AU - Jackson, David J.
T1 - Family Life and Community Participation in Old Age.
JF - Research on Aging
JO - Research on Aging
JA - Res Aging
Y1 - 1979/06//
VL - 1
IS - 2
SP - 233
EP - 251
CY - US
PB - Sage Publications
SN - 0164-0275
SN - 1552-7573
N1 - Accession Number: 2004-20774-006. Partial author list: First Author & Affiliation: Trela, James E.; Department of Sociology, University of Maryland Baltimore County, Catonsville, MD, US. Release Date: 20041227. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Scientific Meeting of the Gerontonlogical Society, 29th, Oct, 1976, New York, NY, US. Conference Note: This article was presented at the aforementioned conference. Major Descriptor: Aging; Community Involvement; Family Relations; Participation; Roles. Minor Descriptor: Communities. Classification: Gerontology (2860). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Jun, 1979.
AB - This article examines the relationship between the availability of family roles and several dimensions of participation in community life in order to determine the interrelatedness and substitutability of these two spheres of role-playing opportunities. The data for this analysis derive from a panel study of 320 aged individuals. The data suggest that, in some cases, community roles may be conceived as functional substitutes for family roles, with the role of spouse being the pivotal link to understanding the relative value of these roles. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family roles
KW - community participation
KW - involvement
KW - family life
KW - community roles
KW - old age
KW - 1979
KW - Aging
KW - Community Involvement
KW - Family Relations
KW - Participation
KW - Roles
KW - Communities
KW - 1979
DO - 10.1177/016402757912006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20774-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08422-012
AN - 2011-08422-012
AU - Brownstein, Michael J.
T1 - Review of Perspectives in endocrine psychobiology.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/06//
VL - 167
IS - 6
SP - 377
EP - 377
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 2011-08422-012. Partial author list: First Author & Affiliation: Brownstein, Michael J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Disorders; Endocrine System; Pathophysiology; Psychobiology. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Brambilla, F. (Ed); Bridges, P. K. (Ed); Endroczi, E. (Ed); Heuser, G. (Ed). Perspectives in endocrine psychobiology=John Wiley & Sons, New York, 590 pp., $39.95; 1978. Page Count: 1. Issue Publication Date: Jun, 1979. Copyright Statement: The Williams & Wilkins Co. 1979.
AB - Reviews the book, Perspectives in endocrine psychobiology edited by F. Brambilla, P. K. Bridges, E. Endroczi, and G. Heuser (1978). This book is not a well integrated textbook dealing with hormones and behavior, nor is it a reference volume. It is instead 13 isolated chapters concerning such disparate topics as steroid hormone binding, control of anterior pituitary function, neurotransmitters and psychosis, psychological and endocrinological changes in puberty, the biological basis of personality, and the pathophysiology and treatment of pituitary tumors. Some of these chapters are well organized reviews of specific areas of basic or clinical science. Unfortunately, the book also contains a number of uncritical reviews of the literature with sensationally long bibliographies. A final chapter providing a cybernetic view of brain activities is so full of jargon that it is nearly incomprehensible. For the most part, what has been said in this book has been said as well or better elsewhere. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - endocrine system
KW - psychobiology
KW - physiology
KW - disorders
KW - 1979
KW - Disorders
KW - Endocrine System
KW - Pathophysiology
KW - Psychobiology
KW - 1979
U2 - Brambilla, F. (Ed); Bridges, P. K. (Ed); Endroczi, E. (Ed); Heuser, G. (Ed). (1978); Perspectives in endocrine psychobiology; John Wiley & Sons, New York, 590 pp., $39.95
DO - 10.1097/00005053-197906000-00012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08422-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08422-021
AN - 2011-08422-021
AU - Ochberg, Frank M.
T1 - Review of Violence and responsibility and Brain dysfunction in aggressive criminals.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/06//
VL - 167
IS - 6
SP - 381
EP - 382
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 2011-08422-021. Partial author list: First Author & Affiliation: Ochberg, Frank M.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Aggressive Behavior; Brain Disorders; Criminal Behavior; Responsibility; Violence. Minor Descriptor: Criminals; Electroencephalography. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Sadoff, Robert L. (Ed). Violence and responsibility=John Wiley & Sons, Somerset, N.J., 139 pp., $14.95; 1978. Monroe, Russell R. Brain dysfunction in aggressive criminals=D. C. Heath and Co., Lexington, Mass., xiii + 223 pp., $17.95; 1978. Page Count: 2. Issue Publication Date: Jun, 1979. Copyright Statement: The Williams & Wilkins Co. 1979.
AB - Reviews the books, Violence and responsibility edited by Robert L. Sadoff (see record [rid]1980-00828-000[/rid]) and Brain dysfunction in aggressive criminals by Russell R. Monroe (1978). Violence and responsibility is a symposium synopsis. Such books are often tedious and disjointed, but this one is short enough to be read at a sitting, and clear enough to be appreciated by the nonspecialist. In fact, the book should appeal to a general medical audience as well as mental health professionals and criminologists. If this volume describes the scope of issues in human violence, Brain dysfunction in aggressive criminals plumbs the depths. Monroe and colleagues at the University of Maryland recently examined intensively and objectively a population of institutionalized recidivists. The conclusions are modest, but of significance: 93 subjects could be assigned to four groups according to EEG abnormality (θ elevation) and behavioral discontrol (self-rating). Monroe et al. explained their assumptions and research strategies well, summarizing related literature as they proceed. Results are presented with less clarity than one might like. The authors promise hypothesis testing rather than hypothesis generation—but this reader is left with more questions than answers. No matter: the authors prove that certain patterns of violent behavior are best comprehended in biological terms, of heuristic and practical significance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violence
KW - responsibility
KW - brain dysfunction
KW - aggressive behavior
KW - criminals
KW - electroencephalography
KW - EEGs
KW - 1979
KW - Aggressive Behavior
KW - Brain Disorders
KW - Criminal Behavior
KW - Responsibility
KW - Violence
KW - Criminals
KW - Electroencephalography
KW - 1979
U2 - Sadoff, Robert L. (Ed). (1978); Violence and responsibility; John Wiley & Sons, Somerset, N.J., 139 pp., $14.95
U2 - Monroe, Russell R. (1978); Brain dysfunction in aggressive criminals; D. C. Heath and Co., Lexington, Mass., xiii + 223 pp., $17.95
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - STRITTMATTER, WARREN J.
AU - HIRATA, FUSAO
AU - AXELROD, JULIUS
T1 - Phospholipid Methylation Unmasks Cryptic, β-Adrenergic Receptors in Rat Reticulocytes.
JO - Science
JF - Science
Y1 - 1979/06/15/
VL - 204
IS - 4398
M3 - Article
SP - 1205
EP - 1207
SN - 00368075
AB - The effect of phospholipid methylation on the number of fadrenergic receptor binding sites was examined in rat reticulocyte membranes. Stimulation of phosphatidylcholine synthesis by the introduction of the methyl donor S-adenosyl-Lmethionine into reticulocyte ghosts increased the number of β-adrenergic receptor binding sites. The appearance of β-adrenergic binding sites was dependent on the formation of phosphatidylcholine by the enzyme that converts phosphatidyl-Nmonomethylethanolamine to phosphatidylcholine, but not on the synthesis of phosphatidyl- N-monomethylethanolamine from phosphatidylethanolamine. Both the synthesis of phosphatidylcholine and the unmasking of cryptic receptors were time and temperature dependent and did not occur in the presence of the methyl transferase inhibitor, S-adenosyl-L-homocysteine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195701; STRITTMATTER, WARREN J. 1; HIRATA, FUSAO 1; AXELROD, JULIUS 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 6/15/1979, Vol. 204 Issue 4398, p1205; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CANTACUZENE, DANIELE
AU - KIRK, KENNETH L.
AU - MCCULLOH, DAVID H.
AU - CREVELING, CYRUS R.
T1 - Effect of Fluorine Substitution on the Agonist Specificity of Norepinephrine.
JO - Science
JF - Science
Y1 - 1979/06/15/
VL - 204
IS - 4398
M3 - Article
SP - 1217
EP - 1219
SN - 00368075
AB - offluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the α - and β-adrenergic agonist properties of norepinephrine. The 6-fluoro isomer is an α -adrenergic agonist with virtually no β agonist activity, while the 2-fluoro isomer is a β-adrenergic agonist with little a activity. The 5-fluoro isomer is equipotent with norepinephrine as an a agonist and significantly more potent as a β agonist. The possible physiochemical basis for these differences is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195706; CANTACUZENE, DANIELE 1,2; KIRK, KENNETH L. 1,2; MCCULLOH, DAVID H. 3; CREVELING, CYRUS R. 3; Affiliations: 1: Laboratory of Chemistry, National Institute of Arthritis, Metabolism; 2: Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases; Issue Info: 6/15/1979, Vol. 204 Issue 4398, p1217; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KNAPKA, JOSEPH J.
T1 - Laboratory Animal Feed.
JO - Science
JF - Science
Y1 - 1979/06/29/
VL - 204
IS - 4400
M3 - Article
SP - 1367
EP - 1367
SN - 00368075
N1 - Accession Number: 85195763; KNAPKA, JOSEPH J. 1; Affiliations: 1: Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 6/29/1979, Vol. 204 Issue 4400, p1367; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Joanne
AU - Schooler, Carmi
AU - Kohn, Melvin L.
AU - Miller, Karen A.
T1 - Women and Work: The Psychological Effects of Occupational Conditions.
JO - American Journal of Sociology
JF - American Journal of Sociology
Y1 - 1979/07//
VL - 85
IS - 1
M3 - Article
SP - 66
EP - 94
SN - 00029602
AB - Examines the effects of working conditions on the psychological functioning of working women, based on 1964 and 1974 studies.
KW - WOMEN -- Employment
KW - PSYCHOLOGY
KW - WORK environment
KW - WOMEN employees
KW - INTERPERSONAL relations
KW - WOMEN
KW - SELF-perception
KW - BEHAVIOR
KW - ATTITUDE (Psychology)
KW - Administrative Processes and Organizational Variables
KW - LABOR MARKET, LABOR FORCE PARTICIPATION, AND LABOR FORCE CHARACTERISTICS
N1 - Accession Number: 15579666; Miller, Joanne 1; Schooler, Carmi 1; Kohn, Melvin L. 1; Miller, Karen A. 1; Affiliations: 1 : National Institute of Mental Health; Source Info: Jul79, Vol. 85 Issue 1, p66; Historical Period: 1964 to 1979; Subject Term: WOMEN -- Employment; Subject Term: PSYCHOLOGY; Subject Term: WORK environment; Subject Term: WOMEN employees; Subject Term: INTERPERSONAL relations; Subject Term: WOMEN; Subject Term: SELF-perception; Subject Term: BEHAVIOR; Subject Term: ATTITUDE (Psychology); Author-Supplied Keyword: Administrative Processes and Organizational Variables; Author-Supplied Keyword: LABOR MARKET, LABOR FORCE PARTICIPATION, AND LABOR FORCE CHARACTERISTICS; Number of Pages: 29p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - GEN
AU - Gordon, Jerry
AU - Hawke, Scott D.
T1 - ANIMAL EXPERIMENTATION.
JO - BioScience
JF - BioScience
Y1 - 1979/07//
VL - 29
IS - 7
M3 - Letter
SP - 397
EP - 397
SN - 00063568
AB - Two letters to the editor are presented in response to the article "Animal Experimentation: The Battle Lines Soften," in the March 1979 issue.
KW - Animal experimentation
KW - Vertebrates
KW - Letters to the editor
KW - Laboratory animals
KW - Bioethics
N1 - Accession Number: 28049390; Gordon, Jerry 1; Hawke, Scott D. 2; Affiliations: 1 : Division of Research Resources, National Institutes of Health, Bethesda, MD 20014; 2 : Department of Biology Willamette University, Salem, OR 97301; Source Info: Jul1979, Vol. 29 Issue 7, p397; Thesaurus Term: Animal experimentation; Thesaurus Term: Vertebrates; Subject Term: Letters to the editor; Subject Term: Laboratory animals; Subject Term: Bioethics; Number of Pages: 1/4p; Document Type: Letter; Full Text Word Count: 317
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Levis, W. R.
AU - Dattner, A. M.
AU - Shaw, J. S.
T1 - Selective defects in T cell function in ataxia-telangiectasia.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/07//
VL - 37
IS - 1
M3 - Article
SP - 44
EP - 49
PB - Wiley-Blackwell
SN - 00099104
AB - We have studied three patients with ataxia-telangiectasia (AT) and found two of them to have a normal mixed leucocyte culture stimulating and responding ability. However, all three patients and one parent had defective cell-mediated lympholysis (CML), even in the face of a potent proliferative response to allogeneic leucocytes. None of these patients showed significant proliferative responses to common microbial antigens (tetanus toxoid, Candida albicans, purified protein derivative (PPD), diphtheria toxoid, influenza). Our studies indicate that the T cell defect in AT preferentially affects certain T cell functions associated with antigen recognition and the generation of allogeneic CML, while sparing the altogeneic proliferative response. The selective deficiency of specific lymphocyte functions in a thymic immunodeficiency with a known defect in DNA repair is consistent with the concept that DNA modulating enzymes are important for T cell function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - LYMPHOCYTES
KW - ATAXIA telangiectasia
KW - CEREBELLUM -- Diseases
KW - CANDIDIASIS
KW - CANDIDA albicans
KW - CLOSTRIDIUM diseases
KW - ANAEROBIC infections
N1 - Accession Number: 16099791; Levis, W. R. 1 Dattner, A. M. 1 Shaw, J. S. 1; Affiliation: 1: Dermatology and Immunology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.; Source Info: Jul1979, Vol. 37 Issue 1, p44; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: ATAXIA telangiectasia; Subject Term: CEREBELLUM -- Diseases; Subject Term: CANDIDIASIS; Subject Term: CANDIDA albicans; Subject Term: CLOSTRIDIUM diseases; Subject Term: ANAEROBIC infections; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wardlaw, A. C.
AU - Parton, R.
AU - Bergman, R. K.
AU - Munoz, J. J.
T1 - Loss of adjuvanticity in rats for the hyperacute form of allergic encephalomyelitis and for reaginic antibody production in mice of a phenotypic variant of Bordetella pertussis .
JO - Immunology
JF - Immunology
Y1 - 1979/07//
VL - 37
IS - 3
M3 - Article
SP - 539
EP - 545
PB - Wiley-Blackwell
SN - 00192805
AB - The adjuvanticity of a phenotypic (C-mode) variant of B. pertussis, known to be deficient in certain immunological and physiopathological properties, was compared to that of the normal (X-mode) strain. The X-mode vaccine was a potent adjuvant for induction of hyperacute experimental allergic encephalomyelitis to guinea-pig spinal cord in Lewis rats whereas C-mode vaccine was inactive. X-mode vaccine was also highly active in the induction of reaginic (both IgE and IgG1) antibodies to ovalbumin in mice while C-mode vaccine caused only a transitory increase in the IgE level. These data support the view that an adjuvant component of B. pertussis, which is probably identical with the histamine-sensitizing and leukocytosis promoting factor, is much diminished in C-mode cells while the lipopolysaccharide adjuvant remains unchanged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGICAL adjuvants
KW - BIOLOGICAL response modifiers
KW - PREVENTIVE medicine
KW - IMMUNOGLOBULINS
KW - BORDETELLA pertussis
KW - ALLERGIC encephalomyelitis
KW - AUTOIMMUNE diseases
N1 - Accession Number: 13988628; Wardlaw, A. C. 1 Parton, R. 1 Bergman, R. K. 2 Munoz, J. J. 1; Affiliation: 1: Microbiology Department, Glasgow University, Glasgow 2: United States Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Jul79, Vol. 37 Issue 3, p539; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: BIOLOGICAL response modifiers; Subject Term: PREVENTIVE medicine; Subject Term: IMMUNOGLOBULINS; Subject Term: BORDETELLA pertussis; Subject Term: ALLERGIC encephalomyelitis; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robbins, Jay H.
AU - Moshell, Alan
T1 - DNA Repair Processes Protect Human Beings from Premature Solar Skin Damage: Evidence from Studies on Xeroderma Pigmentosum.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1979/07//
VL - 73
IS - 1
M3 - Article
SP - 102
EP - 107
SN - 0022202X
AB - The repair of DNA damage by ultraviolet light is defective in the hereditary disease xeroderma pigmentosum. A deoxyribonucleotide excision-proficient form and several excision-deficient forms of xeroderma pigmentosum have been identified. Premature solar skin damage develops in all xeroderma pigmentosum patients. Some patients also have neurological abnormalities caused by premature death of nerve cells. This abnormal aging of the central nervous system and of sun-exposed skin appears to be the result of the abnormal DNA repair processes. Clinical, biological, and physicochemical studies on DNA-repair-dependent processes and on the DNA repair defects in xeroderma pigmentosum are elucidating the mechanisms by which such abnormal aging is prevented in normal human beings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN abnormalities
KW - GENES
KW - AGING
KW - ULTRAVIOLET radiation
KW - GENETIC disorders
KW - NEUROSCIENCES
N1 - Accession Number: 12532789; Robbins, Jay H. 1 Moshell, Alan 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul79, Vol. 73 Issue 1, p102; Subject Term: SKIN abnormalities; Subject Term: GENES; Subject Term: AGING; Subject Term: ULTRAVIOLET radiation; Subject Term: GENETIC disorders; Subject Term: NEUROSCIENCES; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12532789
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ANLYAN, WILLIAM G.
AU - GILLIN, CHRISTIAN
AU - SOLOMON, FREDRIC
AU - MEDD, BRUCE H.
AU - KRIPKE, DANIEL F.
AU - JOSEPH, HERBERT L.
T1 - Sleeping Pills and Insomnia.
JO - Science
JF - Science
Y1 - 1979/07/06/
VL - 205
IS - 4401
M3 - Article
SP - 6
EP - 122
SN - 00368075
N1 - Accession Number: 85268856; ANLYAN, WILLIAM G. 1; GILLIN, CHRISTIAN 2; SOLOMON, FREDRIC 3; MEDD, BRUCE H. 4; KRIPKE, DANIEL F. 5,6; JOSEPH, HERBERT L.; Affiliations: 1: Duke University Medical Center Durham, North Carolina 27710; 2: National Institute of Mental Health Bethesda, Maryland 20857; 3: Institute of Medicine, National Academy of Sciences, Washington, D.C. 20418; 4: Professional Services, Roche Laboratories, Nutley, New Jersey 07110; 5: Department of Psychiatry, University of California, San Diego, La Jolla 92093; 6: Veterans Administration Medical Center, San Diego 92161; Issue Info: 7/ 6/1979, Vol. 205 Issue 4401, p6; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YORKE, JAMES A.
AU - SMALE, STEPHEN
T1 - Continuation Methods.
JO - Science
JF - Science
Y1 - 1979/07/06/
VL - 205
IS - 4401
M3 - Article
SP - 122
EP - 122
SN - 00368075
N1 - Accession Number: 85268858; YORKE, JAMES A. 1,2; SMALE, STEPHEN 3; Affiliations: 1: University of Maryland, College Park 20742; 2: Laboratory of Theoretical Biology, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Mathematics, University of California, Berkeley 94720; Issue Info: 7/ 6/1979, Vol. 205 Issue 4401, p122; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHIMIZU, YOHKO K.
AU - FEINSTONE, STEPHEN M.
AU - PURCELL, ROBERT H.
AU - ALTER, HARVEY J.
AU - LONDON, WILLIAM T.
T1 - Non-A, Non-B Hepatitis: Ultrastructural Evidence for Two Agents in Experimentally Infected Chimpanzees.
JO - Science
JF - Science
Y1 - 1979/07/13/
VL - 205
IS - 4402
M3 - Article
SP - 197
EP - 200
SN - 00368075
AB - Two different ultrastructural alterations were observed in liver cells of chimpanzees inoculated with plasma derived from two different patients with non-A, non-B hepatitis. DurinK the acute phase of illness in one group of four chimpanzees, peculiar tubular structures, composed of two unit membranes with electron-opaque material in between, were observed in the cytoplasm of hepatocytes. In contrast, these structures were never detected in the liver cells of the second group of five chimpanzees that received the second inoculum. However, nuclear changes, usually associated with aggregates of 20- to 27-nanometer particles, were found in hepatocytes of the latter animals. Although these particles resembled viruses, they were not as uniform as small virus particles often appear. In five other chimpanzees inoculated with non-A, non-B hepatitis material not known to be related to the first two inocula, cytoplasmic structures were found in four, and nuclear structures were found in the remaining one. Thus, all 14 chimpanzees inoculated with transmissible non-A, non-B hepatitis agents could be classified as having either nuclear or cytoplasmic changes. These observations add support to epidemiologic data suggesting that there may be more than one agent of non-A, non-B hepatitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85268936; SHIMIZU, YOHKO K. 1; FEINSTONE, STEPHEN M. 1; PURCELL, ROBERT H. 1; ALTER, HARVEY J. 2; LONDON, WILLIAM T. 3; Affiliations: 1: Laboratoy of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institiutes of Health, Bethestla, Maryland 20014; 2: Clinical Center Blood Bank, National Institutes of Health; 3: National Institute of Neurological and Commnunicative Disorders and Strioke, National Institutes of Health; Issue Info: 7/13/1979, Vol. 205 Issue 4402, p197; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chapman, Michael
AU - Hausfater, Glenn
T1 - The Reproductive Consequences of Infanticide in Langurs: A Mathematical Model.
JO - Behavioral Ecology & Sociobiology
JF - Behavioral Ecology & Sociobiology
Y1 - 1979/08//
VL - 5
IS - 3
M3 - Article
SP - 227
EP - 240
SN - 03405443
AB - 1. An analysis of the factors influencing the reproductive success of infanticidal and noninfanticidal adult males in populations of langur monkeys (Genus Presbytis) is presented. Male tenure, defined as an adult male's length of residency in a one-male bisexual group, is demonstrated to be an important factor in any reproductive advantage accruing to infanticidal males. Other factors include the lengths of the female interconception intervals, the time at which adult male replacement occurs relative to the start of any such interval, and whether or not the subsequent replacement male is also infanticidal. 2. Infanticide is found always to confer a reproductive advantage on the resident male in a bisexual group under conditions of subsequent replacement by a noninfanticidal male. Infanticide would thus be expected to spread when introduced into an otherwise noninfanticidal population. Under conditions of subsequent replacement by an infanticidal male, infanticide is found to be advantageous for the resident male only a particular lengths of tenure. Infanticide would thus become fixed only in populations where the distribution of tenure lengths is advantageous for infanticidal males. Accordingly, it is predicted that average or modal tenure length in populations fixed for infanticide should coincide with those tenure lengths theoretically yielding a reproductive advantage for infanticidal males. Three direct estimates of average male tenure obtained from field studies of langur populations are consistent with the predictions of the model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Behavioral Ecology & Sociobiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Reproduction
KW - Langurs
KW - Animals -- Population biology
KW - Presbytis
KW - Infanticide in animals
N1 - Accession Number: 57091779; Chapman, Michael 1; Hausfater, Glenn 2; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205, USA; 2: Cornell University, Ithaca, New York 14853, USA; Issue Info: 1979, Vol. 5 Issue 3, p227; Thesaurus Term: Reproduction; Thesaurus Term: Langurs; Thesaurus Term: Animals -- Population biology; Thesaurus Term: Presbytis; Subject Term: Infanticide in animals; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lawley, T. J.
AU - Ottesen, E. A.
AU - Hiatt, R. A.
AU - Gazze, L. A.
T1 - Circulating immune complexes in acute schistosomiasis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/08//
VL - 37
IS - 2
M3 - Article
SP - 221
EP - 227
PB - Wiley-Blackwell
SN - 00099104
AB - The sera of patients with acute and chronic schistosomiasis were tested for the presence of circulating immune complexes with the 125I-Clq binding assay. Fourteen out of fifteen (93%) patients with acute schistosomiasis had elevated 125I-Clq binding activity, while only two out of eleven (18%) patients with chronic disease had Clq binding complexes. This difference was significant (P≥ 0.001) and paralleled the degree of clinical disease activity between the two groups of patients. IgG and IgM were readily detected in all of these circulating complexes but the specific parasite antigens initiating their formation could not be defined. The level of circulating immune complexes was inversely correlated with the absolute eosinophil counts for individuals in the acutely infected group, an observation compatible with the hypothesis that a functional role for the eosinophil is the destruction and elimination of immune complexes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE complexes
KW - SCHISTOSOMIASIS
KW - CHRONIC diseases
KW - IMMUNOGLOBULINS
KW - EOSINOPHILS
KW - SERUM
N1 - Accession Number: 16434606; Lawley, T. J. 1 Ottesen, E. A. 2 Hiatt, R. A. 3 Gazze, L. A. 4; Affiliation: 1: The Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2: Laboratory of Parasitic Diseases, National Institute of Allergy, National Institutes of Health, Bethesda, Maryland, USA. 3: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. 4: San Juan Laboratories, Center for Disease Control, San Juan, Puerto Rico.; Source Info: Aug1979, Vol. 37 Issue 2, p221; Subject Term: IMMUNE complexes; Subject Term: SCHISTOSOMIASIS; Subject Term: CHRONIC diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: EOSINOPHILS; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - López-Barea, Juan
AU - Chi-Yu Lee
T1 - Mouse-Liver Glutathione Reductase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/08//8/1/79
VL - 98
IS - 2
M3 - Article
SP - 487
EP - 499
PB - Wiley-Blackwell
SN - 00142956
AB - Glutathione reductase from the liver of DBA/2J mice was purified to homogeneity by means of ammonium sulfate fractionation and two subsequent affinity chromatography steps using 8-(6-aminohexyl)-amino-2′-phospho-adenosine diphosphoribose and N6-(6-aminohexyl)-adenosine 2′,5′-bisphosphate-Sepharose columns. A facile procedure for the synthesis of 8-(6-aminohexyl)-amino-2′-phospho-adenosine diphosphoribose is also presented. The purified enzyme exhibits a specific activity of 158 U/mg and an A280/A460 of 6.8. It was shown to be a dimer of Mr 105000 with a Stokes radius of 4.18 nm and an isoelectric point of 6.46. Amino acid composition revealed some similarity between the mouse and the human enzyme. Antibodies against mouse glutathione reductase were raised in rabbits and exhibited high specificity. The catalytic properties of mouse liver glutathione reductase have been studied under a variety of experimental conditions. As with the same enzyme from other sources, the kinetic data are consistent with a ‘branched’ mechanism. The enzyme was stabilized against thermal inactivation at 80 °C by GSSG and less markedly by NADP+and GSH, but not by NADPH or FAD. Incubation of mouse glutathione reductase in the presence of NADPH or NADH, but not NADP+ or NAD+, produced an almost complete inactivation. The inactivation by NADPH was time, pH and concentration dependent. Oxidized glutathione protected the enzyme against inactivation, which could also be reversed by GSSG or other electron acceptors. The enzyme remained in the inactive state even after eliminating the excess NADPH. The inactive enzyme showed the same molecular weight as the active glutathione reductase. The spectral properties of the inactive enzyme have also been studied. It is proposed that auto-inactivation of glutathione reductase by NADPH and the protection as well as reactivation by GSSG play in vivo an important regulatory role. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - LIVER
KW - MICE as laboratory animals
KW - AMMONIUM sulfate
KW - ENZYMES
KW - AFFINITY chromatography
N1 - Accession Number: 13682002; López-Barea, Juan 1 Chi-Yu Lee 2; Affiliation: 1: Departamento de Bioquímica, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain 2: Laboratory of Environmental Mutagenesis, National Institute of Environmental Health Sciences, Resarch Triangle Park, North Carolina, USA; Source Info: 8/1/79, Vol. 98 Issue 2, p487; Subject Term: GLUTATHIONE; Subject Term: LIVER; Subject Term: MICE as laboratory animals; Subject Term: AMMONIUM sulfate; Subject Term: ENZYMES; Subject Term: AFFINITY chromatography; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Metcalfe, D. D.
AU - Corash, L. M.
AU - Kaliner, M.
T1 - Human platelet arylsulphatases: identification and capacity to destroy SRS-A.
JO - Immunology
JF - Immunology
Y1 - 1979/08//
VL - 37
IS - 4
M3 - Article
SP - 723
EP - 729
PB - Wiley-Blackwell
SN - 00192805
AB - Arylsulphatases IIA and IIB have been separately identified in human platelet s by use of anion exchange chromatography and gel filtration, Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA and IIB were inhibited by phosphate and sulphate ions characteristic of this enzyme class. Platelets, upon exposure to ionophore A-23187 or thrombin, discharged arylsulphatase coincident with β-glucuronidase release. Partially purified platelet arylsulphatase lib inactivated rat SRS-A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARYLSULFATASES
KW - SULFATASES
KW - ENZYMES
KW - ENZYMOLOGY
KW - BLOOD platelets
KW - BIOCHEMISTRY
KW - IMMUNOLOGY
N1 - Accession Number: 13987259; Metcalfe, D. D. 1,2 Corash, L. M. 1 Kaliner, M. 1; Affiliation: 1: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and the Hematology Service, Clinical Pathology Department, Clinical Center; National Institutes of Health, Bethesda, Maryland 20014, U.S.A. 2: Harvard Medical School, Robert B. Brigham Hospital, Boston, Massachusetts 02115, U.S.A.; Source Info: Aug79, Vol. 37 Issue 4, p723; Subject Term: ARYLSULFATASES; Subject Term: SULFATASES; Subject Term: ENZYMES; Subject Term: ENZYMOLOGY; Subject Term: BLOOD platelets; Subject Term: BIOCHEMISTRY; Subject Term: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Solomon, Lawrence M.
AU - Kraemer, Kenneth H.
T1 - UV-A: Biological Effects of Ultraviolet Radiation with Emphasis on Human Response to Longwave Ultraviolet (Book).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1979/08//
VL - 73
IS - 2
M3 - Book Review
SP - 202
EP - 202
SN - 0022202X
AB - Reviews the book "UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Response to Longwave Ultraviolet," by John A. Parrish R. Rox Anderson, Frederick Urbach, and Donald Pitts.
KW - ULTRAVIOLET radiation
KW - NONFICTION
KW - PARRISH, John A.
KW - ANDERSON, R. Rox
KW - PITTS, Donald
KW - UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Responses to Longwave Ultraviolet (Book)
N1 - Accession Number: 12581693; Solomon, Lawrence M. Kraemer, Kenneth H. 1; Affiliation: 1: National Cancer Institute, Bethesda, Maryland.; Source Info: Aug79, Vol. 73 Issue 2, p202; Subject Term: ULTRAVIOLET radiation; Subject Term: NONFICTION; Reviews & Products: UV-A: Biological Effects of Ultraviolet Radiation With Emphasis on Human Responses to Longwave Ultraviolet (Book); People: PARRISH, John A.; People: ANDERSON, R. Rox; People: PITTS, Donald; Number of Pages: 1/3p; Document Type: Book Review
L3 - 10.1111/1523-1747.ep12581693
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2011-08425-011
AN - 2011-08425-011
AU - Caine, Eric D.
AU - Mendelson, Wallace B.
AU - Loriaux, D. Lynn
T1 - Neuroendocrine effects of haloperidol in an adolescent with Gilles de la Tourette's disease and delayed onset of puberty.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/08//
VL - 167
IS - 8
SP - 504
EP - 507
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Caine, Eric D., Department of Psychiatry, Neurology, and Pharmacology, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY, US, 14642
N1 - Accession Number: 2011-08425-011. PMID: 288847 Partial author list: First Author & Affiliation: Caine, Eric D.; Department of Psychiatry, Neurology, and Pharmacology, University of Rochester Medical Center, Rochester, NY, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Haloperidol; Neuroendocrinology; Tourette Syndrome. Minor Descriptor: Adolescent Development; Puberty. Classification: Neurological Disorders & Brain Damage (3297); Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30). Age Group: Adolescence (13-17 yrs) (200). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Aug, 1979. Copyright Statement: The Williams & Wilkins Co. 1979.
AB - The effects of haloperidol on the release of prolactin, growth hormone, and luteinizing hormone during sleep were studied in an adolescent male who had Gilles de la Tourette's disease and delayed onset of puberty. At doses of 5 and 2 mg, haloperidol led to an increase of prolactin secretion and a suppression of luteinizing hormone release. Growth hormone was unaffected. Despite these changes, the patient had normal secondary sexual development consistent with puberty. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroendocrinology
KW - haloperidol
KW - adolescent development
KW - Gilles de la Tourette syndrome
KW - puberty onset
KW - 1979
KW - Haloperidol
KW - Neuroendocrinology
KW - Tourette Syndrome
KW - Adolescent Development
KW - Puberty
KW - 1979
DO - 10.1097/00005053-197908000-00011
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06571-019
AN - 2006-06571-019
AU - Iverson, G. J.
T1 - Theorists Have a Field Day.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1979/08//
VL - 24
IS - 8
SP - 640
EP - 642
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06571-019. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Iverson, G. J.; National Eye Institute, New York University, New York, NY, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Stereoscopic Vision; Theories; Visual Field; Visual Perception. Classification: Visual Perception (2323). Population: Human (10). Reviewed Item: Leeuwenberg, E. L. J. (Ed); Buffart, H. F. J. M. (Ed). Formal Theories of Visual Perception=Chichester, England: Wiley, 1978. Pp. xii + 345. $37.50; 1978. Page Count: 3. Issue Publication Date: Aug, 1979.
AB - Reviews the book, Formal Theories of Visual Perception edited by E. L. J. Leeuwenberg and H. F. J. M. Buffart (1978). The volume has been somewhat arbitrarily divided into two sections, each containing eight articles. The first of these sections is entitled 'Theories on Field Effects,' and the second 'Coding Theories of Complex Patterns.' Although neither field effects nor coding is ever clearly denned, the following rule of thumb performs the classification. Lack of space prevents me from more than a brief review of content. By way of consolation perhaps, the book does possess an index! It is beautifully done, stocked with exotic entries such as 'interestingness,' 'random, dot stereopsis pattern,' and 'warning, system early' complete with elaborate cross referencing. Clearly my overall impressions of this book are very mixed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - formal theories
KW - visual perception
KW - complex patterns
KW - coding theories
KW - field effects
KW - stereoscopic vision
KW - 1979
KW - Stereoscopic Vision
KW - Theories
KW - Visual Field
KW - Visual Perception
KW - 1979
U2 - Leeuwenberg, E. L. J. (Ed); Buffart, H. F. J. M. (Ed). (1978); Formal Theories of Visual Perception; Chichester, England: Wiley, 1978. Pp. xii + 345. $37.50
DO - 10.1037/018782
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - CHO, HAN YONG
AU - RHIM, JOHNG SIK
T1 - Cycloheximide-Dependent Reversion of Human Cells Transformed by MSV and Chemical Carcinogen.
JO - Science
JF - Science
Y1 - 1979/08/17/
VL - 205
IS - 4407
M3 - Article
SP - 691
EP - 693
SN - 00368075
AB - The protein syntthesis inhibitor cycloheximide, at a concentration of 0.08 microgram per milliliter, inducedflat morphology within 24 to 48 hours and low saturation density in human osteosarcoma cells transformed by Kirsten murine sarcoma virus (Ki-MSV) or N-methyl-N'-nitro-N-nitrosoguanidine. Removal of the protein synthesis inhibitor caused both transformed cells to revert to the transformed phenotype. The demonstration of cell-surface antigens, cross-reacted with antiserums induced by extracts of both types of transformed human cells, was dependent on the presence or absence of cycloheximide in the culture medium. The results show that protein synthesis is required to maintain the transformed state in virally or chemically transformed human cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269080; CHO, HAN YONG 1; RHIM, JOHNG SIK 2; Affiliations: 1: Department of Experimental Pathology, Walter Reed Army Institute of Research, Washington, D.C. 20012; 2: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p691; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MACDONALD, J. FERGUSON
AU - BARKER, JEFFERY L.
AU - PAUL, STEVEN M.
AU - MARANGOS, PAUL J.
AU - SKOLNICK, PHILIP
T1 - Inosine May Be an Endogenous Ligand for Benzodiazepine Receptors on Cultured Spinal Neurons.
JO - Science
JF - Science
Y1 - 1979/08/17/
VL - 205
IS - 4407
M3 - Article
SP - 715
EP - 717
SN - 00368075
AB - Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepineflurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response 'which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269090; MACDONALD, J. FERGUSON 1; BARKER, JEFFERY L. 1; PAUL, STEVEN M. 2; MARANGOS, PAUL J. 2; SKOLNICK, PHILIP 3; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20014; 2: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolic, and Digestive Diseases, Bethesda, Maryland 20014; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p715; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHWARTZ, WILLIAM J.
AU - SMITH, CAROLYN B.
AU - DAVIDSEN, LESLIE
AU - SAVAKI, HELEN
AU - SOKOLOFF, LOIJIS
AU - MATA, MARINA
AU - FINK, DAVID J.
AU - GAINER, HAROLD
T1 - Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat.
JO - Science
JF - Science
Y1 - 1979/08/17/
VL - 205
IS - 4407
M3 - Article
SP - 723
EP - 725
SN - 00368075
AB - Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response tofunctional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269094; SCHWARTZ, WILLIAM J. 1; SMITH, CAROLYN B. 1; DAVIDSEN, LESLIE 1; SAVAKI, HELEN 1; SOKOLOFF, LOIJIS 1; MATA, MARINA 2; FINK, DAVID J. 2; GAINER, HAROLD 2; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda; Issue Info: 8/17/1979, Vol. 205 Issue 4407, p723; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - UPTON, ARTHUR C.
AU - SHUBIK, PHILIPPE
AU - CLAYSON, DAVID B.
T1 - NCI Bioassay Program.
JO - Science
JF - Science
Y1 - 1979/08/24/
VL - 205
IS - 4408
M3 - Article
SP - 746
EP - 747
SN - 00368075
N1 - Accession Number: 85269096; UPTON, ARTHUR C. 1; SHUBIK, PHILIPPE 2; CLAYSON, DAVID B. 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland 20205; 2: Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42 and Dewey Avenue, Omaha, Nebraska 68105; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p746; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARALDI, M.
AU - GUIDOTTI, A.
AU - SCHWARTZ, J. P.
AU - COSTA, E.
T1 - GABA Receptors in Clonal Cell Lines: A Model for Study of Benzodiazepine Action at Molecular Level.
JO - Science
JF - Science
Y1 - 1979/08/24/
VL - 205
IS - 4408
M3 - Article
SP - 821
EP - 823
SN - 00368075
AB - A "receptor unit" for y-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, andflunitrazepam) and a thermostable endogenotis protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB,(, neuroblastoina and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (I micromolar) prevents the effect of GABA modulin, and in turn GABA (0.1 millimolar) increases the binding of [3H]diazepam. The neuroblastoma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269121; BARALDI, M. 1; GUIDOTTI, A. 1; SCHWARTZ, J. P. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p821; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ESKAY, R. L.
AU - BROWNSTEIN, M. J.
AU - LONG, R. T.
T1 - α-Melanocyte-Stimulating Hormone: Reduction in Adult Rat Brain After Monosodium Glutamate Treatment of Neonates.
JO - Science
JF - Science
Y1 - 1979/08/24/
VL - 205
IS - 4408
M3 - Article
SP - 827
EP - 829
SN - 00368075
AB - Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in α 90 percent loss of ot-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of c-melanocyte-stimulating hormone in the brain suggests that its primary source there is the neuronal perikarya of the arcuate nucleus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269124; ESKAY, R. L. 1; BROWNSTEIN, M. J. 1; LONG, R. T. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p827; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BEACH, RAYMOND
T1 - Mosquitoes: Biting Behavior Inhibited by Ecdysone.
JO - Science
JF - Science
Y1 - 1979/08/24/
VL - 205
IS - 4408
M3 - Article
SP - 829
EP - 831
SN - 00368075
AB - Biting in Anopheles freeborni is inhibited during ovarian development. Biting inhibition is triggered by ecdysone, a hormone produced by the ovary during oogenesis. Biting inhibition does not occur in females after the removal of ovaries, but is restored by replacing ovaries or injecting ecdysone. Ecdysone also inhibits biting behavior when it is fed to females. This is the first example of ecdysone controlling a nonmolt-related behavior in insects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269125; BEACH, RAYMOND 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; Issue Info: 8/24/1979, Vol. 205 Issue 4408, p829; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ANFINSEN, CHRISTIAN B.
AU - CHAMBERLAIN, OWEN
AU - DELBRÜCK, MAX
AU - FLORY, PAUL J.
AU - MCMILLAN, EDWIN M.
T1 - Scientific Ties and Human Rights.
JO - Science
JF - Science
Y1 - 1979/08/31/
VL - 205
IS - 4409
M3 - Article
SP - 854
EP - 855
SN - 00368075
N1 - Accession Number: 85269127; ANFINSEN, CHRISTIAN B. 1; CHAMBERLAIN, OWEN 2; DELBRÜCK, MAX 3; FLORY, PAUL J. 4; MCMILLAN, EDWIN M. 5; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: University of California, Berkeley 94720; 3: Argonne National Laboratory, Batavia, Illinois 60439; 4: Stanford University, Stanford, California 94305; 5: University of California, Berkeley; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p854; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MCCARTHY, CHARLES R.
T1 - Research Subjects: Rights and Regulations.
JO - Science
JF - Science
Y1 - 1979/08/31/
VL - 205
IS - 4409
M3 - Article
SP - 855
EP - 856
SN - 00368075
N1 - Accession Number: 85269128; MCCARTHY, CHARLES R. 1; Affiliations: 1: Office for Protection from Research Risks, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p855; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BROZOSKI, THOMAS J.
AU - BROWN, ROGER M.
AU - ROSVOLD, H. E.
AU - GOLDMAN, PATRICIA S.
T1 - Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey.
JO - Science
JF - Science
Y1 - 1979/08/31/
VL - 205
IS - 4409
M3 - Article
SP - 929
EP - 932
SN - 00368075
AB - Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269164; BROZOSKI, THOMAS J. 1; BROWN, ROGER M. 1; ROSVOLD, H. E. 1; GOLDMAN, PATRICIA S. 1; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p929; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lum, L. G.
AU - Muchmore, A. V.
AU - Decker, Jean M.
AU - Blaese, R. M.
T1 - MICC cytotoxic effector function of human T lymphocyte subpopulations bearing Fc-receptors for IgG and IgM.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/09//
VL - 37
IS - 3
M3 - Article
SP - 558
EP - 561
PB - Wiley-Blackwell
SN - 00099104
AB - Purified subpopulations of human T lymphocytes bearing Fc-IgG and Fc-IgM receptors were studied for their ability to mediate mitogen (PHA) induced cellular cytotoxicity (MICC) to chicken erythrocyte (CRBC) and DBA/Mastocytoma P815Y tumour cell targets. There were marked differences in the ability of the Fc-IgG receptor-bearing T cell (T γ) and the Fc-IgM (Tμ) to mediating MICC to CRBC and P815Y target cells, Tγ cells were very efficient killers of CRBC and Tμ cells had no cytotoxic activity to CRBC. On the other hand, both the Tγ and Tμ subpopulations were able to mediate MICC to P815Y tumour cell targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - MITOGENS
KW - ERYTHROCYTES
KW - T cells
KW - TUMORS
KW - CELLS
N1 - Accession Number: 15989068; Lum, L. G. 1 Muchmore, A. V. 1 Decker, Jean M. 1 Blaese, R. M. 1; Affiliation: 1: Metabolism Branch, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, USA.; Source Info: Sep1979, Vol. 37 Issue 3, p558; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Subject Term: ERYTHROCYTES; Subject Term: T cells; Subject Term: TUMORS; Subject Term: CELLS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dattner, Alan M.
AU - Mann, Dean L.
AU - Levis, William R.
T1 - Studies on the Contact Sensitization of Man with Simple Chemicals: V. Clonal Priming Allows Direct in Vitro Assessment of Autologous HLA-associated Factors Required for Immune Response to Dinitrochlorobenzene.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1979/09//
VL - 73
IS - 3
M3 - Article
SP - 246
EP - 249
SN - 0022202X
AB - Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first culture with dinitrophenylated-antigens yield a population of cells which respond in an accelerated manner to the same or similar antigen in second culture. Using this "clonal priming" approach, we have demonstrated that such a primed population showed maximal proliferative response to dinitrophenylated autologous cells. These DNP primed clones also showed responses to some dinitrophenylated allogeneic leukocytes. The magnitude of the accelerated blastogenic response with allogeneic leukocytes varied in most instances in relation to the degree of sharing of HLA-A, B, and DRw antigens with the original autologous stimulator. These findings show that the self-specific factors recognized in conjunction with the dinitrophenyl antigen are closely but not invariably associated with established major histocompatibility (MHC)-associated serologic typing results. While DNP primed clones fail to respond to unmodified autologous leukocytes, they often show significant responses to unmodified allogeneic leukocytes. If such accelerated responses to unmodified allogeneic leukocytes are not the result of nonspecific activation of allogeneic responding lymphocyte clones, these findings further indicate that DNP modified self can resemble some alloantigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DINITROCHLOROBENZENE
KW - IMMUNE response
KW - TRANSFER factor (Immunology)
KW - ANTIGENS
KW - LYMPHOCYTES
KW - CELL proliferation
N1 - Accession Number: 12514334; Dattner, Alan M. 1 Mann, Dean L. 1 Levis, William R. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep79, Vol. 73 Issue 3, p246; Subject Term: DINITROCHLOROBENZENE; Subject Term: IMMUNE response; Subject Term: TRANSFER factor (Immunology); Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12514334
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12514334&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ware, James H.
T1 - Applications of Statistics (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1979/09//
VL - 74
IS - 367
M3 - Book Review
SP - 735
SN - 01621459
AB - Reviews the book "Applications of Statistics," edited by Paruchuri R. Krishnaiah.
KW - STATISTICS
KW - NONFICTION
KW - KRISHNAIAH, Parnchuri
KW - KRISHNAIAH, Paruchuri R.
KW - APPLICATIONS of Statistics (Book)
N1 - Accession Number: 4605637; Ware, James H. 1; Affiliations: 1: National Institutes of Health.; Issue Info: Sep79, Vol. 74 Issue 367, p735; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: APPLICATIONS of Statistics (Book); People: KRISHNAIAH, Parnchuri; People: KRISHNAIAH, Paruchuri R.; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2011-08428-001
AN - 2011-08428-001
AU - Gordon, Malcolm A.
AU - Greenspan, Stanley I.
T1 - A critique of ethological studies with children.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/09//
VL - 167
IS - 9
SP - 519
EP - 521
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Greenspan, Stanley I., Mental Health Study Center, National Institute of Mental Health, 2340 University Boulevard East, Adelphi, MD, US, 20783
N1 - Accession Number: 2011-08428-001. Partial author list: First Author & Affiliation: Gordon, Malcolm A.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Development; Observation Methods; Social Interaction; Intellectual Development Disorder. Minor Descriptor: Language Development; Parent Child Relations. Classification: Mental Retardation (3256). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Reviewed Item: Sackett, Gene P. (Ed). Observing behavior, Vol. I: Theory and applications in mental retardation=University Park Press, Baltimore, Vol. I: xv + 416 pp. $24.50; 1978. Sackett, Gene P. (Ed). Observing behavior, Vol. II: Data collection and analysis Methods=University Park Press, Baltimore, Vol. II: xiii + 110 pp. $12.50; 1978. Page Count: 3. Issue Publication Date: Sep, 1979.
AB - Reviews the book(s), Observing behavior, Vol. I: Theory and applications in mental retardation by Gene P. Sackett (see record [rid]1979-08721-000[/rid]) &Observing behavior,Vol. II: data collection and analysis Methods by Gene P. Sackett (see record [rid]1979-07552-000[/rid]). The papers in these two volumes are from a 1976 conference, 'Application of Observational-Ethological Methods to the Study of Mental Retardation.' The conference was jointly sponsored by the Mental Retardation Program of the National Institute of Child Health and Human Development and the Child Development and Mental Retardation Center of the University of Washington. It was convened to promote the study of the real world behavior of retarded persons in contrast to the more usual laboratory, questionnaire, and clinical studies. Volume I contains 17 papers describing observational methodology or reporting studies in parent-infant interaction, language development, cognitive development, and social interaction. Volume II contains six chapters on methodological and statistical considerations. In 'observational methods' a nonparticipant records the frequency and/ or duration of categorized behavioral events in natural human social settings. These volumes do succeed in giving a good overview of current methods of naturalistic quantitative observations and their relations to other methodologies. An added bonus is that several of the papers provide good overviews of substantive research areas and would be of interest to researchers outside the mental retardation field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethology
KW - mental retardation
KW - theory
KW - applications
KW - parent child interaction
KW - social interaction
KW - language development
KW - cognitive development
KW - behavior observation
KW - 1979
KW - Cognitive Development
KW - Observation Methods
KW - Social Interaction
KW - Intellectual Development Disorder
KW - Language Development
KW - Parent Child Relations
KW - 1979
U2 - Sackett, Gene P. (Ed). (1978); Observing behavior, Vol. I: Theory and applications in mental retardation; University Park Press, Baltimore, Vol. I: xv + 416 pp. $24.50
U2 - Sackett, Gene P. (Ed). (1978); Observing behavior, Vol. II: Data collection and analysis Methods; University Park Press, Baltimore, Vol. II: xiii + 110 pp. $12.50
DO - 10.1097/00005053-197909000-00001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08428-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08428-008
AN - 2011-08428-008
AU - Tuma, A. Hussain
AU - May, Philip R. A.
T1 - And if that doesn't work, what next … ? A study of treatment failures in schizophrenia.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/09//
VL - 167
IS - 9
SP - 566
EP - 571
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Tuma, A. Hussain, Clinical Research Branch, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, 5600 Fishers Lane, Room 10C-24, Rockville, MD, US, 20857
N1 - Accession Number: 2011-08428-008. PMID: 479870 Partial author list: First Author & Affiliation: Tuma, A. Hussain; Clinical Research Branch, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Rockville, MD, US. Release Date: 20110829. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Group Psychotherapy; Schizophrenia; Tranquilizing Drugs; Treatment Outcomes. Minor Descriptor: Failure. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Menninger Health-Sickness Rating Scale; MACC Behavioral Adjustment Scale. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 1979. Copyright Statement: Williams & Wilkins Co. 1979.
AB - A systematic study of schizophrenic patients who did not respond satisfactorily to one of five different forms of treatment given under controlled conditions showed that almost all of them responded satisfactorily to subsequent treatment with the combination of ataraxic drugs and group psychotherapy. Whatever the original form of treatment, and despite subsequent retreatment with drugs and group psychotherapy, there was a treatment- resistant core—a few patients who either responded very slowly or who improved relatively little. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment failures
KW - schizophrenia
KW - ataraxic drugs
KW - group psychotherapy
KW - 1979
KW - Drug Therapy
KW - Group Psychotherapy
KW - Schizophrenia
KW - Tranquilizing Drugs
KW - Treatment Outcomes
KW - Failure
KW - 1979
U1 - Sponsor: State of California, Department of Mental Hygiene, US. Other Details: Research Service of the Veterans Administration. Recipients: No recipient indicated
U1 - Sponsor: United States Department of Health, Education, and Welfare, United States Public Health Service, National Institute of Mental Health, US. Grant: MH 02719; MH 04589; PH 43-66-49. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: RR-3. Other Details: Computing Facility at the Center for the Health Sciences, University of California at Los Angeles. Recipients: No recipient indicated
DO - 10.1097/00005053-197909000-00008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08428-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08428-009
AN - 2011-08428-009
AU - Targum, Steven D.
AU - Davenport, Yolande B.
AU - Webster, Marian J.
T1 - Postpartum mania in bipolar manic-depressive patients withdrawn from lithium carbonate.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/09//
VL - 167
IS - 9
SP - 572
EP - 574
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Targum, Steven D., Psychiatric Institute, 4460 MacArthur Boulevard, N.W., Washington, DC, US, 20007
N1 - Accession Number: 2011-08428-009. PMID: 479871 Partial author list: First Author & Affiliation: Targum, Steven D.; National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, US. Release Date: 20110829. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Drug Withdrawal; Lithium Carbonate; Mania; Pregnancy. Minor Descriptor: Major Depression. Classification: Affective Disorders (3211). Population: Human (10); Female (40); Inpatient (50); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Methodology: Clinical Case Study; Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Sep, 1979. Copyright Statement: Williams & Wilkins Co. 1979.
AB - Three women, previously diagnosed as bipolar I manic-depressive, were withdrawn from lithium carbonate prophylaxis immediately prior to their pregnancies. The patients had been euthymic while on lithium carbonate for at least 3% years prior to their pregnancies. Two of the three patients developed a manic syndrome within 2 weeks postpartum. The use of lithium carbonate during pregnancy, and particularly in the postpartum period, requires reassessment. We advocate an ongoing clinical relationship and the reinstitution of lithium in the third trimester in most cases. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - postpartum mania
KW - bipolar disorder
KW - mania
KW - lithium carbonate withdrawal
KW - prophylaxis
KW - pregnancy
KW - manic depressive patients
KW - 1979
KW - Bipolar Disorder
KW - Drug Withdrawal
KW - Lithium Carbonate
KW - Mania
KW - Pregnancy
KW - Major Depression
KW - 1979
DO - 10.1097/00005053-197909000-00009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08428-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - COHEN, JACK S.
T1 - Aiding Vietnam.
JO - Science
JF - Science
Y1 - 1979/09/07/
VL - 205
IS - 4410
M3 - Article
SP - 954
EP - 954
SN - 00368075
N1 - Accession Number: 85269168; COHEN, JACK S. 1; Affiliations: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p954; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GILLIN, J. CHRISTIAN
AU - MENDELSON, WALLACE B.
AU - DEMENT, WILLIAM C.
AU - SOLOMON, FREDRIC
T1 - Flurazepam and Insomnia.
JO - Science
JF - Science
Y1 - 1979/09/07/
VL - 205
IS - 4410
M3 - Article
SP - 954
EP - 955
SN - 00368075
N1 - Accession Number: 85269169; GILLIN, J. CHRISTIAN 1; MENDELSON, WALLACE B. 1; DEMENT, WILLIAM C. 2; SOLOMON, FREDRIC 3; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Stanford University Medical Center, Stanford, California 94305; 3: Institute of Medicine, National Academy of Sciences, Washington, D.C. 20418; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p954; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOYD, SUELLYN C.
AU - SASAME, HENRY A.
AU - BOYD, MICHAEL R.
T1 - High Concentrations of Glutathione in Glandular Stomach: Possible Implications for Carcinogenesis.
JO - Science
JF - Science
Y1 - 1979/09/07/
VL - 205
IS - 4410
M3 - Article
SP - 1010
EP - 1012
SN - 00368075
AB - In laboratory rodents, concentrations of reduced glutathione (GSH) are exceedingly high (up to 7 to 8 millimolar) in the glandular gastric tissue compared to concentrations in other portions of the gastrointestinal tract or to those of most other organs. Gastric GSH varies diurnally, with the highest levels occurring in the late afternoon or early evening. Starvation, treatment with diethyl maleate, or cold-restraint stress all caused marked decreases in stomach GSH, whereas treatment with cobaltous chloride caused an increase in the GSH concentrations. The physiological significance of the high gastric GSH is unknown, but because this endogenous compound may strongly modulate (decrease or increase) the macromolecular binding of certain chemicals capable of inducing stomach tumors, the possible role of glutathione in the pathogenesis of chemically induced gastric cancer should be considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269201; BOYD, SUELLYN C. 1; SASAME, HENRY A. 2; BOYD, MICHAEL R. 3; Affiliations: 1: Field Studies and Statistics Program, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; 2: Lahoratory of Chemical Pharmacology, National Heart, Lung and Blood Institute, Bethesda, Maryland 20205; 3: Molecular Toxicology Section, Clinical Pharmacology Branch, National Cancer Institute; Issue Info: 9/ 7/1979, Vol. 205 Issue 4410, p1010; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KRETCHMER, NORMAN
AU - HEGSTED, D. MARK
T1 - Nutrition Program.
JO - Science
JF - Science
Y1 - 1979/09/14/
VL - 205
IS - 4411
M3 - Article
SP - 1083
EP - 1084
SN - 00368075
N1 - Accession Number: 85195799; KRETCHMER, NORMAN 1; HEGSTED, D. MARK 2; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Human Nutrition Center, Science and Education Administration, U.S. Department of Agriculture, Washington, D.C. 20250; Issue Info: 9/14/1979, Vol. 205 Issue 4411, p1083; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ISRAEL, MARK A.
AU - CHAN, HARDY W.
AU - MARTIN, MALCOLM A.
AU - ROWE, WALLACE P.
T1 - Molecular Cloning of Polyoma Virus DNA in Escherichia coli: Oncogenicity Testing in Hamsters.
JO - Science
JF - Science
Y1 - 1979/09/14/
VL - 205
IS - 4411
M3 - Article
SP - 1140
EP - 1142
SN - 00368075
AB - Inoculation of suckling hamsters with 2 X 108 live cells of Escherichia coli K12 strain xI 776, carrying the complete genome of polyoma virus in a recombinant plasmid, failed to induce tumors in any of 32 recipients. Also, lambda phage DNA and particles with a monomeric insert of polyoma DNA did not induce tumors. Purified recombinant plasmid DNA, as well as phage particles and DNA containing a head-to-tail dimer of polyoma DNA, showed a low degree of oncogenicity, comparable to that of polyoma DNA prepared from mouse cells. These findings support the previous conclusions, based on infectivity assays in mice, that propagation of polyoma virus DNA as a component of recombinant DNA molecules in E. coli K12 reduces its biologic activity many orders of magnitude relative to the virus itself. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195825; ISRAEL, MARK A. 1; CHAN, HARDY W. 1; MARTIN, MALCOLM A. 1; ROWE, WALLACE P. 2; Affiliations: 1: Recombinant DNA Research Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 9/14/1979, Vol. 205 Issue 4411, p1140; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHO-CHUNG, YOON SANG
AU - ARCHIBALD, DAVID
AU - CLAIR, TIMoTHY
T1 - Cyclic AMP Receptor Triggers Nuclear Protein Phosphorylation in a Hormone-Dependent Mammary Tumor Cell-Free System.
JO - Science
JF - Science
Y1 - 1979/09/28/
VL - 205
IS - 4413
M3 - Article
SP - 1390
EP - 1392
SN - 00368075
AB - Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[ a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamidine, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone- dependent mammary tumor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269249; CHO-CHUNG, YOON SANG 1; ARCHIBALD, DAVID 1; CLAIR, TIMoTHY 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 9/28/1979, Vol. 205 Issue 4413, p1390; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rogan, Walter J.
T1 - OVERVIEW OF ENVIRONMENTALISM.
JO - BioScience
JF - BioScience
Y1 - 1979/10//
VL - 29
IS - 10
M3 - Book Review
SP - 623
EP - 623
SN - 00063568
AB - The article reviews the book "Environment, Technology, and Health: Human Ecology in Historical Perspective," by Merril Eisenbud.
KW - Environmentalism
KW - Nonfiction
KW - Eisenbud, Merril
KW - Environment, Technology & Health: Human Ecology in Historical Perspective (Book)
N1 - Accession Number: 28050922; Rogan, Walter J. 1; Affiliations: 1 : National Institute of Environmental Health Sciences Research Triangle Park, NC; Source Info: Oct1979, Vol. 29 Issue 10, p623; Thesaurus Term: Environmentalism; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 676
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Hirschfeld, Robert M. A.
AU - Klerman, Gerald L.
T1 - Treatment of depression in the elderly.
JO - Geriatrics
JF - Geriatrics
Y1 - 1979/10//
VL - 34
IS - 10
M3 - Article
SP - 51
EP - 57
SN - 0016867X
N1 - Accession Number: 18936381; Hirschfeld, Robert M. A. 1; Klerman, Gerald L. 2; Source Information: Oct1979, Vol. 34 Issue 10, p51; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 3091
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2013-42799-024
AN - 2013-42799-024
AU - Curtz, Elisabeth R.
AU - Trickett, Penelope K.
T1 - Review of Social change and human purpose: Toward understanding and action.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1979/10//
VL - 49
IS - 4
SP - 724
EP - 727
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42799-024. Partial author list: First Author & Affiliation: Curtz, Elisabeth R.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Nature; Social Change; Social Issues; Social Sciences. Minor Descriptor: Experimentation; Social Justice. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Warren, Roland L. Social change and human purpose: Toward understanding and action=348 pp. $11.50. Rand McNally, Chicago; 1977. Page Count: 4. Issue Publication Date: Oct, 1979.
AB - Reviews the book, Social change and human purpose: Toward understanding and action by Roland L. Warren (1977). Warren's book is like an oasis in the desert. In a brief space it brings order and life to innumerable particles of social science theory and research. The particular strength of the book is Warren's talent for describing very complex and intertwined situations in a clear and simple way, and doing so without minimizing their complexity. The volume is designed as a student text, and as such has a number of advantages for the general reader. The text draws heavily on the full range of relevant literature for both discussion and example. The organizing tool that Warren develops in the book is a six-part descriptive model. The second half of the book is devoted to consideration of these broader strategic questions at the three different target-system levels. Warren has no easy answers for the multitude of difficult problems which his book brings into focus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social change
KW - human purpose
KW - social science theory
KW - research
KW - difficult problems
KW - 1979
KW - Human Nature
KW - Social Change
KW - Social Issues
KW - Social Sciences
KW - Experimentation
KW - Social Justice
KW - 1979
U2 - Warren, Roland L. (1977); Social change and human purpose: Toward understanding and action; 348 pp. $11.50. Rand McNally, Chicago
DO - 10.1037/h0098986
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42799-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - TALBOT, BERNARD
T1 - Recombinant DNA Rules.
JO - Science
JF - Science
Y1 - 1979/10/05/
VL - 206
IS - 4414
M3 - Article
SP - 9
EP - 9
SN - 00368075
N1 - Accession Number: 85195882; TALBOT, BERNARD 1; Affiliations: 1: Office, Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/ 5/1979, Vol. 206 Issue 4414, p9; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BINDERMAN, I.
AU - GREENE, R. M.
AU - PENNYPACKER, J. P.
T1 - Calcification of Differentiating Skeletal Mesenchyme in vitro.
JO - Science
JF - Science
Y1 - 1979/10/12/
VL - 206
IS - 4415
M3 - Article
SP - 222
EP - 225
SN - 00368075
AB - Embryonic limb-bud mesenchyme was induced to calcify in culture by the addition of 3 mM inorganic phosphate to the medium. Phosphate enhanced calcification of the matrix produced by mesenchymal orfibroblast-like cells, whereas no calcification was evident in areas where cartilage had developed. However, calcification was induced throughout the cell layer by altering the cartilage matrix properties with certain enzymes or by changing the phenotypic expression of the cells with vitamin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195961; BINDERMAN, I. 1; GREENE, R. M. 1; PENNYPACKER, J. P. 1; Affiliations: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/12/1979, Vol. 206 Issue 4415, p222; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - William, Leah A.
AU - Piatigorsky, Joran
T1 - Comparative and Evolutionary Aspects of ℘-Crystallin in the Vertebrate Lens.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/10/15/
VL - 100
IS - 2
M3 - Article
SP - 349
EP - 357
PB - Wiley-Blackwell
SN - 00142956
AB - We have utilized [3H]cDNA · DNA annealing (using S1 endonuclease resistance as an assay) to detect the presence of sequences complementary to chick δ-crystallin mRNA in the genome of fish (salmon, herring), amphibians (frog, newt), reptiles (python, gekko, caiman), birds (quail, turkey, duck), and mammals (mouse, calf), and have compared several physical parameters of δ-crystallin of the reptiles and birds. The rate and extent of chick δ-crystallin [3H]cDNA · DNA annealing were comparable among the birds, and indicated that the δ-crystallin sequences are in the unique fraction of the genome. On the average, about one-fifth as much annealing took place with the reptiles as with the birds, and no annealing was observed with the fish, amphibians and mammals. The avian and reptilian δ-crystallins had subunit molecular weights near 50000 and native molecular weights near 200000, as judged by sodium dodecylsulfate/urea/polyacrylamide gel electrophoresis and agarose gel chromatography, respectively, indicating that the subunit structure of δ-crystallin has been largely conserved. Electrophoresis of the peptides generated by digestion with Staphylococcus aureus V8 protease indicated that the primary structures of the different reptilian and avian δ-crystallins were similar but not identical. The isoelectric points of the δ-crystallins ranged between pH 5 and 7, depending on the organism. In general, the reptilian δ-crystallins had the higher isoelectric points. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - GENOMES
KW - AMPHIBIANS
KW - CHROMATOGRAPHIC analysis
KW - STAPHYLOCOCCUS aureus
KW - PEPTIDES
KW - ELECTROPHORESIS
N1 - Accession Number: 13686733; William, Leah A. 1 Piatigorsky, Joran 1; Affiliation: 1: Section on Cellular Differentiation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Devleopment, National Institutes of Health, Bethesda, Maryland; Source Info: 10/15/79, Vol. 100 Issue 2, p349; Subject Term: DNA; Subject Term: GENOMES; Subject Term: AMPHIBIANS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: PEPTIDES; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - POTKIN, STEVEN G.
AU - KAROUM, FAROUK
AU - LIN-WHEI CHUANG
AU - CANNON-SPOOR, H. E.
AU - PHILLIPS, INGRID
AU - WYATT, RICHARD JED
T1 - Phenylethylamine in Paranoid Chronic Schizophrenia.
JO - Science
JF - Science
Y1 - 1979/10/26/
VL - 206
IS - 4417
M3 - Article
SP - 470
EP - 471
SN - 00368075
AB - Phenylethylamine (PEA) is an endogenous amine that is structurally and pharmacologically related to amphetamine. Urinary PEA excretion is significantly higher in paranoid chronic schizophrenics than in nonparanoid chronic schizophrenics and normal controls. Diet, hospitalization, and medication do not account for differences in PEA concentrations. These findings offer some indication that PEA may be an endogenous amphetamine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158975; POTKIN, STEVEN G. 1; KAROUM, FAROUK 1; LIN-WHEI CHUANG 1; CANNON-SPOOR, H. E. 1; PHILLIPS, INGRID 1; WYATT, RICHARD JED 1; Affiliations: 1: Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washlngton, D.C. 20032; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p470; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLEINMAN, JOEL E.
AU - POTKIN, STEVEN
AU - ALAN ROGOL, ALAN
AU - BUCHSBAUM, MONTE S.
AU - MURPHY, DENNIS L.
AU - GILLIN, J. CHRISTIAN
AU - NASRALLAH, HENRY A.
AU - WYATT, RICHARD JED
T1 - A Correlation Between Platelet Monoamine Oxidase Activity and Plasma Prolactin Concentrations in Man.
JO - Science
JF - Science
Y1 - 1979/10/26/
VL - 206
IS - 4417
M3 - Article
SP - 479
EP - 481
SN - 00368075
AB - Increases in plasma prolactin concentrations produced by a-methyl-ptyrosine, a catecholamine synthesis inhibitor, varied inversely with baseline platelet monoamine oxidase activity in 12 patients with chronic schizophrenia. In normal volunteers with low monoamine oxidase activity and in unmedicated patients with chronic schizophrenia, plasma prolactin concentrations varied directly with platelet monoamine oxidase activity. No such relationship wasfound in normal subjects with high platelet monoamine oxidase activity. These data suggest that platelet monoamine oxidase activity reflects monoaminergic activity in the tubero-infundibular system, which in turn affects plasma prolactin concentrations. This relationship may be important in patients with low platelet monoamine oxidase activity, such as some chronic schizophrenics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85158980; KLEINMAN, JOEL E. 1; POTKIN, STEVEN 1; ALAN ROGOL, ALAN 2; BUCHSBAUM, MONTE S. 3; MURPHY, DENNIS L. 4; GILLIN, J. CHRISTIAN 5; NASRALLAH, HENRY A. 5; WYATT, RICHARD JED 5; Affiliations: 1: Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Pediatrics, University of Virginia Medical Center, Charlottesville 22908; 3: Laboratory of Clinical Psychophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Neuropharmacology, National Institute of Mental Health; 5: Laboratory of Clinical Psychopharmacology, Saint Elizabeths Hospital; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p479; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JACKSON, TOGWELL A.
AU - WELLNER, DANIEL
AU - BONDY, STEPHEN C.
T1 - Stereospecific Sorption of L Amino Acids by Colloidal Clay.
JO - Science
JF - Science
Y1 - 1979/10/26/
VL - 206
IS - 4417
M3 - Article
SP - 483
EP - 484
SN - 00368075
N1 - Accession Number: 85158982; JACKSON, TOGWELL A. 1; WELLNER, DANIEL 2; BONDY, STEPHEN C. 3; Affiliations: 1: Freshwater Institute, 501 Universtiy Crescent, Winnipeg, Manitoba, R3T 2N6 Canada; 2: Department of Biochemistry, Cornell University Medical College, News York 10021; 3: Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 10/26/1979, Vol. 206 Issue 4417, p483; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Coulter, Charles L.
T1 - Instrument Needs in Biology.
JO - BioScience
JF - BioScience
Y1 - 1979/11//
VL - 29
IS - 11
M3 - Article
SP - 678
EP - 680
SN - 00063568
AB - The article presents detailed information on scientific instruments needed in biological research. A recent study suggests that the effects of a deteriorating instrument base are being felt in a variety of ways in all of experimental science. A survey by the U.S. National Science Foundation showed that the cost of scientific instruments in five basic science areas had increased fourfold since 1970. New instruments such as cell sorters and new technologies such as computer modeling of populations and image analysis have recently been applied creatively in biology. The need for these and other new tools is growing, and biologists are becoming more dependent on these tools in their investigations.
KW - Biologists
KW - Scientific apparatus & instruments
KW - Biological research
KW - Research -- Equipment & supplies
KW - Surveys
KW - Medical technology
KW - Image analysis
KW - Flow cytometry
KW - United States
KW - National Science Foundation (U.S.)
N1 - Accession Number: 28049978; Coulter, Charles L. 1; Affiliations: 1 : Head of the Biological Structure Section, Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, MD 20205; Source Info: Nov1979, Vol. 29 Issue 11, p678; Thesaurus Term: Biologists; Subject Term: Scientific apparatus & instruments; Subject Term: Biological research; Subject Term: Research -- Equipment & supplies; Subject Term: Surveys; Subject Term: Medical technology; Subject Term: Image analysis; Subject Term: Flow cytometry; Subject: United States; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2984
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Adler, W. H.
T1 - CELL BIOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1979/11//
VL - 29
IS - 11
M3 - Book Review
SP - 682
EP - 682
SN - 00063568
AB - The article reviews the book "Stem Cells and Tissue Homeostasis," edited by B. I. Lord, C. S. Rotten, and R. J. Cole.
KW - Stem cells
KW - Nonfiction
KW - Lord, B. I.
KW - Rotten, C. S.
KW - Cole, R. J.
KW - Stem Cells & Tissue Homeostasis (Book)
N1 - Accession Number: 28049981; Adler, W. H. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospital, Baltimore, MD 21224; Source Info: Nov1979, Vol. 29 Issue 11, p682; Subject Term: Stem cells; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 551
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Levenbook, L.
T1 - INSECT BIOCHEMISTRY.
JO - BioScience
JF - BioScience
Y1 - 1979/11//
VL - 29
IS - 11
M3 - Book Review
SP - 689
EP - 689
SN - 00063568
AB - The article reviews the book "Biochemistry of Insects," edited by Morris Rockstein.
KW - Insects
KW - Nonfiction
KW - Rockstein, Morris
KW - Biochemistry of Insects (Book)
N1 - Accession Number: 28049990; Levenbook, L. 1; Affiliations: 1 : National Institutes of Health, Laboratory of Physical Biology, Bethesda, Md 20205; Source Info: Nov1979, Vol. 29 Issue 11, p689; Thesaurus Term: Insects; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 647
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Lipkin, Lewis E.
T1 - IMAGE ANALYSIS.
JO - BioScience
JF - BioScience
Y1 - 1979/11//
VL - 29
IS - 11
M3 - Book Review
SP - 691
EP - 691
SN - 00063568
AB - The article reviews the book "Image Analysis, Enhancement and Interpretation," Volume 7 "Practical Methods in Electron Microscopy," by D. L. Misell.
KW - Electron microscopy
KW - Nonfiction
KW - Misell, D. L.
KW - Image Analysis, Enhancement & Interpretation: Practical Methods in Electron Microscopy (Book)
N1 - Accession Number: 28049993; Lipkin, Lewis E. 1; Affiliations: 1 : National Cancer Institute, National Institutes of Health, Bethesda, MD 20205; Source Info: Nov1979, Vol. 29 Issue 11, p691; Subject Term: Electron microscopy; Subject Term: Nonfiction; Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 760
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DP - EBSCOhost
DB - 8gh
ER -
TY - GEN
AU - Hearing, Vincent J.
T1 - TYROSINE HYDROXYLATION.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1979/11//
VL - 73
IS - 5 Part 1
M3 - Letter
SP - 392
EP - 393
SN - 0022202X
AB - Presents a letter to the editor related to tyrosine hydroxylation.
KW - TYROSINE
KW - LETTERS to the editor
N1 - Accession Number: 12551743; Hearing, Vincent J. 1; Affiliation: 1: Senior Investigator, Dermatology Branch, National Cancer Institute.; Source Info: Nov79, Vol. 73 Issue 5 Part 1, p392; Subject Term: TYROSINE; Subject Term: LETTERS to the editor; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/1523-1747.ep12551743
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gottlieb, Sheldon H.
AU - Engel, Bernard T.
T1 - Autonomic Interactions in the Control of Heart Rate in the Monkey.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1979/11//
VL - 16
IS - 6
M3 - Article
SP - 528
EP - 536
SN - 00485772
AB - Each of 5 monkeys (Macaca mulatta) was operantly conditioned to raise and to lower heart rate consistently and reliably. Following such training the animals were tested using autonomic blocking agents (methyl-atropine bromide and l-propranolol) to characterize the autonomic mechanisms mediating such control. The results were: 1) In the undrngged animal the extent to which it decreases its heart rate over a 2048-sec period is a linear function of the baseline heart rate; 2) A linear relationship between baseline heart rate and heart rate decrease also is present within the first 128 sec; 3) There is a less consistent relationship between baseline heart rate and change in heart rate when animals must increase heart rate; 4) Vagal blockade significantly attenuates the ability of most animals to increase heart rate, primarily by reducing their ability to produce large, relatively rapid increases; 5) Sympathetic blockade significantly attenuates the ability of most animals to increase heart rate both in terms of overall changes and in terms of large, relatively rapid responses; 6) Vagal blockade very significantly attenuates the ability of all animals to slow heart rate; 7) Sympathetic blockade facilitates the ability of most animals to slow heart rate. These findings show that both branches of the autonomic nervous system participate in the operant control of heart rate. The relative role of one branch or the other in a given experiment will depend upon the baseline conditions at the time of testing, and upon the requirements -- i.e., raising or lowering of heart rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHESUS monkey
KW - HEART beat
KW - OPERANT conditioning
KW - CONDITIONED response
KW - AUTONOMIC nervous system
KW - ATROPINE
KW - Atropine.
KW - Autonomic nervous system
KW - Heart rate
KW - Intrinsic heart rate
KW - Monkeys
KW - Operant conditioning
N1 - Accession Number: 11196996; Gottlieb, Sheldon H. 1 Engel, Bernard T. 2; Affiliation: 1: Department of Medicine, Division of Cardiology, Baltimore City Hospitals, and The Johns Hopkins University School of Medicine. 2: Gerontology Research Center (Baltimore), National Institute on Aging, National Institutes of Health, P11 5, U.S. Department of Health, Education, and Welfare, Bethesda, and The Baltimore City Hospitals, Baltimore, and The Johns Hopkins University School of Medicine.; Source Info: Nov1979, Vol. 16 Issue 6, p528; Subject Term: RHESUS monkey; Subject Term: HEART beat; Subject Term: OPERANT conditioning; Subject Term: CONDITIONED response; Subject Term: AUTONOMIC nervous system; Subject Term: ATROPINE; Author-Supplied Keyword: Atropine.; Author-Supplied Keyword: Autonomic nervous system; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Intrinsic heart rate; Author-Supplied Keyword: Monkeys; Author-Supplied Keyword: Operant conditioning; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-8986.ep11196996
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2011-08309-019
AN - 2011-08309-019
AU - Gaarder, Kenneth
T1 - Review of Normal psychology of the aging process.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1979/11//
VL - 167
IS - 11
SP - 716
EP - 717
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 2011-08309-019. Partial author list: First Author & Affiliation: Gaarder, Kenneth; National Institute on Aging, Bethesda, MD, US. Release Date: 20111219. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Gerontology; Geropsychology; Physiological Aging; Psychology. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Reviewed Item: Zinberg, Norman E. (Ed); Kaufman, Irving (Ed). Normal psychology of the aging process=Rev. International Universities Press, New York, xxiii + 285 pp. $15.00; 1978. Page Count: 2. Issue Publication Date: Nov, 1979. Copyright Statement: The Williams & Wilkins Co. 1979.
AB - Reviews the book, Normal Psychology of the Aging Process edited by Norman E. Zinberg and Irving Kaufman (see record [rid]1979-30664-000[/rid]). This is a revised and expanded version of the Boston Society for Gerontological Psychiatry Conference proceedings published in 1963. This book and its original version are both guaranteed a place within the structure of general and psychoanalytic knowledge of aging, since they represent the thoughts of respected and experienced clinicians who are knowledgeable about both patients and psychoanalysis. When the proceedings were first published, the study of normal aging was only beginning to interest investigators and clinicians. As aging research comes to command the attention it deserves, readers who consider this their area of focus should be aware of Zinberg and Kaufman's book. For the already knowledgeable gerontologist, however, the clinical examples and the range of issues covered provide little that has not now been considered. For the clinician or student wishing an introduction to geriatrics and gerontology or to the narrower focus of the normal psychology of aging, there are many better textbooks. This is a book which is less important now than when the first edition was published. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gerontology
KW - geriatrics
KW - aging
KW - psychology
KW - 1979
KW - Gerontology
KW - Geropsychology
KW - Physiological Aging
KW - Psychology
KW - 1979
U2 - Zinberg, Norman E. (Ed); Kaufman, Irving (Ed). (1978); Normal psychology of the aging process; Rev. International Universities Press, New York, xxiii + 285 pp. $15.00
DO - 10.1097/00005053-197911000-00019
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - BROWN, NIGEL A.
AU - GOULDING, EUGENIA H.
AU - FABRO, SERGIO
T1 - Ethanol Embryotoxicity: Direct Effects on Mammalian Embryos in vitro.
JO - Science
JF - Science
Y1 - 1979/11/02/
VL - 206
IS - 4418
M3 - Article
SP - 573
EP - 575
SN - 00368075
AB - Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic-features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethano, which causes reduced embryonic cellular proliferation early in gestation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437582; BROWN, NIGEL A. 1,2; GOULDING, EUGENIA H. 3; FABRO, SERGIO 1,4; Affiliations: 1: Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Department of Pharmacology, George Washington University Medical Center, Washington, D.C. 20037; 3: Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences; 4: Departments of Pharmacology and Obstetrics and Gynecology, George Washington University Medical Center; Issue Info: 11/ 2/1979, Vol. 206 Issue 4418, p573; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NIJHOUT, H. FREDERIK
AU - SHEFFIELD, HARLEY G.
T1 - Antennal Hair Erection in Male Mosquitoes: A New Mechanical Effector in Insects.
JO - Science
JF - Science
Y1 - 1979/11/02/
VL - 206
IS - 4418
M3 - Article
SP - 595
EP - 596
SN - 00368075
AB - Male Anopheles mosquitoes erect their antennal hairs prior to mating. The erectile mechanism resides in a unique annulus at the base of each hair whorl. It appears that the insect regulates the degree of hydration of this annulus. When the annulus is made to swell the attached hairs are pushed to their erect position. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437592; NIJHOUT, H. FREDERIK 1,2; SHEFFIELD, HARLEY G. 2; Affiliations: 1: Department of Zoology, Duke University, Durham, North Carolina 27706; 2: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/ 2/1979, Vol. 206 Issue 4418, p595; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEBBER, RICHARD L.
AU - BLUM, HARRY
T1 - Angular Invariants in Developing Human Mandibles.
JO - Science
JF - Science
Y1 - 1979/11/09/
VL - 206
IS - 4419
M3 - Article
SP - 689
EP - 691
SN - 00368075
AB - Recent studies of lateral cephalograms based on symmetric-axis analyses of the mandibular border yield angles that appear to be uninfluenced by gross changes in mandibular shape over age and between individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159016; WEBBER, RICHARD L. 1; BLUM, HARRY 2; Affiliations: 1: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; 2: Division of Computer Research and Technology, National Institutes of Health; Issue Info: 11/ 9/1979, Vol. 206 Issue 4419, p689; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEHR, THOMAS A.
AU - WIRZ-JUSTICE, ANNA
AU - GOODWIN, FREDERICK K.
AU - DUNCAN, WALLACE
AU - GILLIN, J. CHRISTIAN
T1 - Phase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant.
JO - Science
JF - Science
Y1 - 1979/11/09/
VL - 206
IS - 4419
M3 - Article
SP - 710
EP - 713
SN - 00368075
AB - Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159025; WEHR, THOMAS A. 1; WIRZ-JUSTICE, ANNA 1; GOODWIN, FREDERICK K. 1; DUNCAN, WALLACE 2; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 11/ 9/1979, Vol. 206 Issue 4419, p710; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FREED, WILLIAM J.
AU - PERLOW, MARK J.
AU - WYATT, RICHARD JED
T1 - Calcitonin: Inhibitory Effect on Eating in Rats.
JO - Science
JF - Science
Y1 - 1979/11/16/
VL - 206
IS - 4420
M3 - Article
SP - 850
EP - 852
SN - 00368075
AB - Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159063; FREED, WILLIAM J. 1; PERLOW, MARK J.; WYATT, RICHARD JED; Affiliations: 1: Unit, Geriatric Psychiatry, Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, Intramural Research Program, National institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 11/16/1979, Vol. 206 Issue 4420, p850; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHIRO, GIOVANNI DI
AU - BROOKS, RODNEY A.
T1 - The 1979 Nobel Prize in Physiology or Medicine.
JO - Science
JF - Science
Y1 - 1979/11/30/
VL - 206
IS - 4422
M3 - Article
SP - 1060
EP - 1062
SN - 00368075
N1 - Accession Number: 85361581; CHIRO, GIOVANNI DI 1; BROOKS, RODNEY A. 1; Affiliations: 1: Neuroradiology and Computed Tomography Section, Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/30/1979, Vol. 206 Issue 4422, p1060; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RABINOVITZ, MARCO
AU - UEHARA, YOSHIMASA
AU - VISTICA, DAVID T.
T1 - Differential Competition with Cytotoxic Agents: An Approach to Selectivity in Cancer Chemotherapy.
JO - Science
JF - Science
Y1 - 1979/11/30/
VL - 206
IS - 4422
M3 - Article
SP - 1085
EP - 1087
SN - 00368075
AB - An approach to increasing the selectivity of cancer chemotherapeutic agents is presented in which noncytotoxic competitive substrates are used to discern the differences in structural requirements for transport of cytotoxic agents between tumor cells and a sensitive host tissue, the hematopoietic precursor cells of the bone marrow. Examples are given for two such systems, one responsible for the transport of nucleosides and another for the transport of amino acids. Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cells. Conversely, homoleucine is twice as effective in reducing the toxicity of melphalan for L1210 cells as it is for bone marrow cells. These observations can serve as a basis for the development of bone marrow protective agents and for the design of cytotoxic agents that may be preferentially transported into tumor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361596; RABINOVITZ, MARCO 1; UEHARA, YOSHIMASA 1; VISTICA, DAVID T. 1; Affiliations: 1: Laboratory of Medicinal Chemistry and Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 11/30/1979, Vol. 206 Issue 4422, p1085; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenberg, Martin
AU - Court, Donald
T1 - REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1979/12//
VL - 13
M3 - Article
SP - 319
EP - 353
PB - Annual Reviews Inc.
SN - 00664197
AB - Evaluates he DNA sequences involved in the promotion and termination of RNA transcription. Characterization of the promoter and terminator site mutations; Correlation of the structural and functional similarities and differences occurring in regulatory site; Influence to the interaction between polymerase and DNA.
KW - NUCLEOTIDE sequence
KW - MUTATION (Biology)
KW - DNA polymerases
KW - RNA
N1 - Accession Number: 12409210; Rosenberg, Martin 1 Court, Donald; Affiliation: 1: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 1979, Vol. 13, p319; Subject Term: NUCLEOTIDE sequence; Subject Term: MUTATION (Biology); Subject Term: DNA polymerases; Subject Term: RNA; Number of Pages: 35p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Evans, V. Jeffery
AU - Macdonald, H. Malcolm
T1 - Family and Population in Nineteenth-Century America.
JO - Social Science Quarterly (University of Texas Press)
JF - Social Science Quarterly (University of Texas Press)
Y1 - 1979/12//
VL - 60
IS - 3
M3 - Book Review
SP - 541
EP - 542
PB - University of Texas Press
SN - 00384941
AB - Reviews the book "Family and Population in Nineteenth-Century America," edited by Tamara K. Hareven and Maris A. Vinovskis.
KW - FAMILIES
KW - NONFICTION
KW - HAREVEN, Tamara K.
KW - VINOVSKIS, Maris A.
KW - FAMILY & Population in Nineteenth-Century America (Book)
N1 - Accession Number: 16557750; Evans, V. Jeffery 1 Macdonald, H. Malcolm; Affiliation: 1: Center for Population Research National Institute for Child Health and Human Development; Source Info: Dec1979, Vol. 60 Issue 3, p541; Subject Term: FAMILIES; Subject Term: NONFICTION; Reviews & Products: FAMILY & Population in Nineteenth-Century America (Book); People: HAREVEN, Tamara K.; People: VINOVSKIS, Maris A.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JEFFREY, A. M.
AU - GRZESKOWIAK, K.
AU - WEINSTEIN, I. B.
AU - NAKANISHI, K.
AU - ROLLER, P.
AU - HARVEY, R. G.
T1 - Benzo(a)pyrene-7,8-dihydrodiol 9,10-Oxide Adenosine and Deoxyadenosine Adducts: Structure and Stereochemistry.
JO - Science
JF - Science
Y1 - 1979/12/14/
VL - 206
IS - 4424
M3 - Article
SP - 1309
EP - 1311
SN - 00368075
AB - The structure and absolute stereoconfigurations off our adenosine adducts with (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of adenine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195995; JEFFREY, A. M. 1; GRZESKOWIAK, K. 1; WEINSTEIN, I. B. 1; NAKANISHI, K. 1; ROLLER, P. 2; HARVEY, R. G. 3; Affiliations: 1: Cancer Center Institute of Cancer Research and Department of Chemistry, Columbia University, New York 10032; 2: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014; 3: Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637; Issue Info: 12/14/1979, Vol. 206 Issue 4424, p1309; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GADEK, JAMES E.
AU - FELLS, GERALD A.
AU - CRYSTAL, RONALD G.
T1 - Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans.
JO - Science
JF - Science
Y1 - 1979/12/14/
VL - 206
IS - 4424
M3 - Article
SP - 1315
EP - 1316
SN - 00368075
AB - Current concepts of the pathogenesis of emphysema suggest that it results from an imbalance of elastase and antielastase activity within the alveolar structures. Although emphysema that is associated with hereditary deficiency of serum α1-antitrypsin conforms to this scheme, the major risk factor in the more common form of emphysema is cigarette smoking. A study was designed to evaluate the premise that cigarette smoking may be associated with an acquired, functional defect in lung a,-antitrypsin. Determination of the antielastase activity of α1-antitrypsin obtained from the lungs of smoking and nonsmoking individuals revealed a nearly two fold reduction in the functional activity of this elastase inhibitor in the lungs of cigarette smokers. These data suggest that cigarette smokers may lose some of the normal antielastase protective screen of the lower respiratory tract, making them more vulnerable to destructive lung disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195998; GADEK, JAMES E. 1; FELLS, GERALD A. 1; CRYSTAL, RONALD G. 1; Affiliations: 1: Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/14/1979, Vol. 206 Issue 4424, p1315; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2004-16199-002
AN - 2004-16199-002
AU - Gallagher, Dolores
AU - Thompson, Larry W.
AU - Levy, Sandra M.
ED - Poon, Leonard W.
ED - Poon, Leonard W., (Ed)
T1 - Clinical psychological assessment of older adults.
T2 - Aging in the 1980s: Psychological issues.
Y1 - 1980///
SP - 19
EP - 40
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-15-2
N1 - Accession Number: 2004-16199-002. Partial author list: First Author & Affiliation: Gallagher, Dolores; Adult Counseling Center, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Gerontology; Psychological Assessment. Classification: Clinical Psychological Testing (2224); Gerontology (2860). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 22.
AB - Psychological assessment, as traditionally done, has not been adequate for obtaining a valid profile of older people's functional status. What is needed in the 1980s is evaluation of systematically obtained data from a number of substantive domains (e.g., physical health, coping skills, cognitive functioning, affective status) and careful integration of these data to formulate intervention programs. Current assessment procedures frequently used with the elderly are reviewed critically, and specific directions for future research are recommended. This chapter reviews problems, issues, and substantive areas related to clinical psychological assessment of the elderly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical psychological assessment
KW - older adults
KW - elderly
KW - 1980
KW - Gerontology
KW - Psychological Assessment
KW - 1980
DO - 10.1037/10050-002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16199-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2004-16199-003
AN - 2004-16199-003
AU - Levy, Sandra M.
AU - Derogatis, Leonard R.
AU - Gallagher, Dolores
AU - Gatz, Margaret
ED - Poon, Leonard W.
ED - Poon, Leonard W., (Ed)
T1 - Intervention with older adults and the evaluation of outcome.
T2 - Aging in the 1980s: Psychological issues.
Y1 - 1980///
SP - 41
EP - 61
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-15-2
N1 - Accession Number: 2004-16199-003. Partial author list: First Author & Affiliation: Levy, Sandra M.; National Cancer Institute, National Institutes of Health, Washington, DC, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Biopsychosocial Approach; Disorders; Gerontology; Treatment Outcomes; Treatment. Minor Descriptor: Hospitalization; Outpatient Treatment. Classification: Psychological & Physical Disorders (3200); Gerontology (2860). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 21.
AB - Common forms of disorder found in older adults are discussed within a biopsychosocial framework, and interventions that seem to make a difference in quality of functioning are examined. Promising research directions for outpatient treatment include analysis of change mechanisms within cognitive intervention strategies and examination of essential parameters of outcome variables, such as time to criterion for successful therapeutic outcome. Research directions for inpatient treatment include examining commonalities across effective treatments, such as the enhancement of a sense of control, and a further examination of factors affecting person-environment fit. Questions concerning process and outcome research design, as well as methodology, are also considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - older adults
KW - disorder
KW - cognitive intervention strategies
KW - therapeutic outcome
KW - outpatient treatment
KW - inpatient treatment
KW - biopsychosocial framework
KW - 1980
KW - Biopsychosocial Approach
KW - Disorders
KW - Gerontology
KW - Treatment Outcomes
KW - Treatment
KW - Hospitalization
KW - Outpatient Treatment
KW - 1980
DO - 10.1037/10050-003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16199-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2004-16199-018
AN - 2004-16199-018
AU - Giambra, Leonard M.
AU - Arenberg, David
ED - Poon, Leonard W.
ED - Poon, Leonard W., (Ed)
T1 - Problem Solving, Concept Learning, and Aging.
T2 - Aging in the 1980s: Psychological issues.
Y1 - 1980///
SP - 253
EP - 259
CY - Washington, DC, US
PB - American Psychological Association
SN - 0-912704-15-2
N1 - Accession Number: 2004-16199-018. Partial author list: First Author & Affiliation: Giambra, Leonard M.; Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, US. Release Date: 20040802. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-912704-15-2, Paperback. Language: English. Major Descriptor: Aging; Concept Formation; Problem Solving. Classification: Cognitive & Perceptual Development (2820). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 7.
AB - Studies of problem solving and aging published since 1974 are briefly reviewed and are categorized according to the task studied: (a) concept learning, (b) problem solving other than concept learning, and (c) training to improve problem-solving performance. Some prescriptions for aging research in this area in the next decade include the following proposals: (a) to design aging studies within the framework of theories of problem solving that have been fruitful with young adults; (b) to avoid studying problems that have not been thoroughly investigated with young adults; (c) to adopt 'thinking-aloud' procedures; and (d) to study a small number of individuals over many problems. The goal of research in this next decade should be to predict individual performance as a function of age. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - problem solving
KW - concept learning
KW - aging
KW - 1980
KW - Aging
KW - Concept Formation
KW - Problem Solving
KW - 1980
DO - 10.1037/10050-018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16199-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Regazzi, John J
AU - Bellicha, Terry
T1 - Alcohol information: some perspectives on the development of a problem-oriented system
JO - Alcohol information: some perspectives on the development of a problem-oriented system
JF - Alcohol information: some perspectives on the development of a problem-oriented system
Y1 - 1980///
M3 - Book
AB - The development of the alcohol information retrieval system (airs) is discussed within the context of a problem-oriented information system. Characteristics of such an approach are described. The types of information which need to be assembled for the field of alcohol studies are also generally characterized. The function and the types of services provided by the automated data base are discussed, and a brief description of basis, the data management system presently used by airs, is also included.
N1 - Accession Number: ISTA1502836; Regazzi, John J 1; Bellicha, Terry 2; Affiliations: 1 : Center Of Alcohol Studies, Rutgers Univ., New Brunswick, Nj; 2 : Division of Prevention, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD; Source Info: 1980; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Wagner, Edward H.
AU - Slome, Cecil
AU - Carroll, Carol L.
AU - Warner, Jeanne T.
AU - Pittman, A. Wayne
AU - Pickard, C. Glenn
AU - Williams, Benjamin O.
AU - Cornoni-Huntley, Joan C.
T1 - Hypertension Control in a Rural Biracial Community: Successes and Failures of Primary Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/01//
VL - 70
IS - 1
M3 - Article
SP - 48
EP - 55
PB - American Public Health Association
SN - 00900036
AB - Abstract: Through a total community survey and a medical record review, we examined hypertension awareness, treatment, and control in a biracial rural community rich in primary care resources. The overall prevalence of hypertension among the 2,939 respondents was 20.5 per ¢; 82 per ¢ of hypertensives were aware of their condition: 68 per ¢ were on treatment; and 55 per ¢ were under control. Comparison of data sources revealed discrepancies and misconceptions about diagnosis and treatment. Nearly one-third of the population reported a history of hypertension despite the fact that most of them were untreated and were normotensive. Conversely. one-third of "undetected" hypertensives had notation of the diagnosis in their medical records. Discontinuation of treatment accounted for over one-half of aware but untreated hypertension. Misconceptions about therapy contributed to failures of control in the treated group. These findings suggest that difficulties in the transmission of information about hypertension contribute importantly to failures of control. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL surveys
KW - MEDICAL records
KW - HYPERTENSION
KW - MEDICAL care
KW - MEDICAL informatics
KW - RURAL development
N1 - Accession Number: 4953718; Wagner, Edward H. 1 Slome, Cecil 1 Carroll, Carol L. 2 Warner, Jeanne T. 1,3 Pittman, A. Wayne 4 Pickard, C. Glenn 3 Williams, Benjamin O. 5 Cornoni-Huntley, Joan C. 6; Affiliation: 1: Department of Epidemiology, University of North Carolina School of Public Health, Rosenau HaIl 201 H. Chapel Hill, NC 27514. 2: Highway Safety Research Center, UNC. 3: Department of Medicine, UNC, School of Medicine. 4: School of Pharmacy, UNC. 5: Burroughs-Welcome Company. 6: National Institute on Aging, National Institutes of Health.; Source Info: Jan1980, Vol. 70 Issue 1, p48; Subject Term: SOCIAL surveys; Subject Term: MEDICAL records; Subject Term: HYPERTENSION; Subject Term: MEDICAL care; Subject Term: MEDICAL informatics; Subject Term: RURAL development; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singer, Maxine
T1 - THE RECOMBINANT DNA DEBATE.
JO - BioScience
JF - BioScience
Y1 - 1980/01//
VL - 30
IS - 1
M3 - Book Review
SP - 40
EP - 40
SN - 00063568
AB - The article reviews the book "A Double Image of the Double Helix: The Recombinant DNA Debate," by Clifford Grobstein.
KW - Recombinant DNA
KW - Nonfiction
KW - Grobstein, Clifford
KW - Double Image of the Double Helix: The Recombinant DNA Debate, A (Book)
N1 - Accession Number: 28049428; Singer, Maxine 1; Affiliations: 1 : Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda,MD 20205; Source Info: Jan1980, Vol. 30 Issue 1, p40; Subject Term: Recombinant DNA; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 453
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Trudgett, A.
AU - Bellini, W. J.
AU - Mingioli, E. S.
AU - McFarlin, D. E.
T1 - Antibodies to the structural polypeptides of measles virus following acute infection and in SSPE.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/01//
VL - 39
IS - 1
M3 - Article
SP - 652
EP - 656
PB - Wiley-Blackwell
SN - 00099104
AB - A solid-phase radioimmunoassay was used to determine the specificity of IgG antibodies from normal sera, sera and CSF from patients with SSPE for the structural polypeptides of measles virus. The polypeptide specificity of antibodies from these sources were qualitatively similar; these results indicate antigenic cross-reactivity between SSPE-derived (Mantooth) and non-SSPE-derived strains of measles virus and stimulation of antibody formation by comparable antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases
KW - PARAMYXOVIRUSES
KW - MEASLES virus
KW - IMMUNOGLOBULIN G
KW - MEASLES
KW - CANINE distemper virus
N1 - Accession Number: 17335387; Trudgett, A. 1 Bellini, W. J. 1 Mingioli, E. S. 1 McFarlin, D. E. 1; Affiliation: 1: Neuroimmunology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, USA.; Source Info: Jan1980, Vol. 39 Issue 1, p652; Subject Term: VIRUS diseases; Subject Term: PARAMYXOVIRUSES; Subject Term: MEASLES virus; Subject Term: IMMUNOGLOBULIN G; Subject Term: MEASLES; Subject Term: CANINE distemper virus; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, Edward F.
AU - Murphy, Dennis L.
AU - Waldman, Ivan N.
T1 - DENIAL AND SOMATIZATION AS CHARACTERISTICS OF BIPOLAR DEPRESSED GROUPS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1980/01//
VL - 36
IS - 1
M3 - Article
SP - 159
EP - 162
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article reports on denial and somatization as characteristics of bipolar depressed groups. In recent years, a number of studies that used clinical self-report tests have suggested that bipolar depressed groups generally report less overall psychopathology than unipolar groups. Studies of bipolar depressed groups with the Minnesota Multiphasic Personality Inventory (MMPI) consistently have shown lower scores on most clinical scales than unipolar groups, but these group differences mostly disappeared during the recovery period. To account for the differential effect in self-reported psychopathology between groups, it has been suggested that relatively high MMPI scores in the unipolar group are associated with socially undesirable response sets.
KW - SOMATIZATION disorder
KW - PATHOLOGICAL psychology
KW - DEPRESSED persons
KW - GROUPS
KW - MENTALLY ill
KW - PSYCHOTHERAPY
N1 - Accession Number: 15934160; Donnelly, Edward F. 1 Murphy, Dennis L. 2 Waldman, Ivan N. 1; Affiliation: 1: National Institute of Mental Health, St. Elizabeths Hospital, Washington, D. C. 2: National Institute of Mental Health, Bethesda, Maryland.; Source Info: Jan1980, Vol. 36 Issue 1, p159; Subject Term: SOMATIZATION disorder; Subject Term: PATHOLOGICAL psychology; Subject Term: DEPRESSED persons; Subject Term: GROUPS; Subject Term: MENTALLY ill; Subject Term: PSYCHOTHERAPY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawley, T. J.
AU - Strober, W.
AU - Yaoita, H.
AU - Katz, S. I.
T1 - Small Intestinal Biopsies and HLA Types in Dermatitis Herpetiformis Patients with Granular and Linear IgA Skin Deposits.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/01//
VL - 74
IS - 1
M3 - Article
SP - 9
EP - 12
SN - 0022202X
AB - In this study we determined whether dermatitis herpetiformis patients whose skin contained linear IgA deposits differ from those whose skin contained granular IgA deposits with regard to the presence of gluten-sensitive enteropathy and with regard to the prevalence of certain histocompatibility antigens. We performed multiple Rubin tube intestinal biopsies on 11 patients, 6 with linear and 5 with granular IgA deposits. The gut biopsies were evaluated histopathologically in a blinded fashion. We found that none of the patients with linear deposits (5 with lamina lucida and 1 with sub-basal lamina deposits) had detectable jejunal abnormalities whereas all of those with granular deposits had jejunal abnormalities (villous atrophy and increased numbers of intraepithelial lymphocytes). In parallel studies HLA typing was performed in 10 patients with linear IgA deposits and in 49 patients with granular deposits. Only 30% of those with linear deposits had HLA-B8, a prevalence not significantly different from that of the normal population (24%); in contrast, 88% of those with granular deposits had HLA-B8, a prevalence significantly greater than in the normal population (p < 0.001). We therefore conclude that patients with linear IgA deposits have a disease which is pathophysiologically different from those with granular IgA deposits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATITIS herpetiformis
KW - IMMUNOGLOBULIN A
KW - HISTOCOMPATIBILITY antigens
KW - INTESTINAL diseases
KW - BIOPSY
KW - SKIN diseases
N1 - Accession Number: 12514565; Lawley, T. J. Strober, W. 1 Yaoita, H. Katz, S. I.; Affiliation: 1: Dermatology and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1980, Vol. 74 Issue 1, p9; Subject Term: DERMATITIS herpetiformis; Subject Term: IMMUNOGLOBULIN A; Subject Term: HISTOCOMPATIBILITY antigens; Subject Term: INTESTINAL diseases; Subject Term: BIOPSY; Subject Term: SKIN diseases; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12514565
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Foidart, Jean-Michel
AU - Murray, J. Clifford
AU - Martin, George R.
AU - Katz, Stephen I.
T1 - The Epidermal Cell which Selectively Adheres to a Collagen Substrate is the Basal Cell.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/01//
VL - 74
IS - 1
M3 - Article
SP - 54
EP - 58
SN - 0022202X
AB - In order to determine whether a specific subpopulation of epidermal cells selectively attaches to collagen substrates in vitro, epidermal cell suspensions, obtained by trypsinization of guinea pig skin, were incubated on type I or type IV collagen-coated glass cover slips. It was noted, morphologically and by electronic volume measurements, that small round cells, as opposed to the larger angulated flat cells, adhered to the collagen substrates. To further characterize the attached cells, the percentage of basal cells was determined in the attached cell population and in the initial epidermal cell suspension. Basal cells were identified by indirect immunofluorescence in 2 ways: (1) by the presence of pemphigoid antigen and (2) by the absence of upper cytoplasmic antigen, which is present in all keratinocytes except the basal cells. Whereas in the initial guinea pig epidermal cell suspensions about 50% of the cells were basal cells using either of these 2 criteria, 86-97% of the cells which adhered to the collagen substrates were basal cells. Human basal cells, as defined by pemphigoid antigen, also selectively adhered to the collagen substrates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - COLLAGEN
KW - GUINEA pigs
KW - EPIDERMIS
KW - IMMUNOFLUORESCENCE
KW - CELL proliferation
N1 - Accession Number: 12514618; Stanley, John R. 1 Foidart, Jean-Michel 2 Murray, J. Clifford 2 Martin, George R. 2 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Laboratory of Developmental Biology and Anomalies of the National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1980, Vol. 74 Issue 1, p54; Subject Term: SKIN; Subject Term: COLLAGEN; Subject Term: GUINEA pigs; Subject Term: EPIDERMIS; Subject Term: IMMUNOFLUORESCENCE; Subject Term: CELL proliferation; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12514618
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-11732-001
AN - 2009-11732-001
AU - Mosher, Loren R.
AU - Meltzer, Herbert Y.
T1 - Drugs and psychosocial treatment: Editors’ introduction.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1980///
VL - 6
IS - 1
SP - 8
EP - 9
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Mosher, Loren R., CSS, CRB, NIMH, 5600 Fishers Lane, Rm. 10-95, Rockville, MD, US, 20857
N1 - Accession Number: 2009-11732-001. PMID: 6102796 Partial author list: First Author & Affiliation: Mosher, Loren R.; Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Psychotherapy; Schizophrenia; Adjunctive Treatment. Minor Descriptor: Drug Therapy; Neuroleptic Drugs. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1980.
AB - The role of psychosocial approaches to the care and treatment of some forms of psychosis, particularly schizophrenia, has been overshadowed in the minds of some clinicians and investigators by the establishment of the efficacy of the major tranquilizers in the treatment of these conditions. During the past two decades, there has been a tendency to conceive of neuroleptic treatment as the only proven form of treatment for psychosis. Fortunately new evidence has begun to accumulate, albeit not of the same rigor of design and analysis associated with clinical psychopharmacology, that psychosocial approaches are not only useful but have different effects on outcome in schizophrenia than neuroleptics have, and thus can complement their use. As emphasized in three of the articles in this issue (Mosher and Keith, Gunderson, and Wallace et al.), the comprehensiveness of the psychosocial treatment program and the availability of a social network to reinforce, maintain, and support the gains achieved by more formal treatment programs, of which psychopharmacology may be an essential element, appear to be critical. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - psychosocial treatment
KW - psychotherapy
KW - neuroleptic drugs
KW - drug therapy
KW - adjunctive treatment
KW - 1980
KW - Psychotherapy
KW - Schizophrenia
KW - Adjunctive Treatment
KW - Drug Therapy
KW - Neuroleptic Drugs
KW - 1980
DO - 10.1093/schbul/6.1.8
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42175-018
AN - 2013-42175-018
AU - Shore, Milton F.
T1 - Review of Violent delinquents and The psychological world of the juvenile delinquent.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1980/01//
VL - 50
IS - 1
SP - 169
EP - 171
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42175-018. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Juvenile Delinquency; Male Delinquency; Sociocultural Factors. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Reviewed Item: Strasburg, Paul A. Violent delinquents=272 pp. $16.95. Sovereign Books, New York; 1978. Offer, Daniel; Marohn, Richard C.; Ostrov, Eric. The psychological world of the juvenile delinquent=224 pp. $15.00. Basic Books, New York; 1979. Page Count: 3. Issue Publication Date: Jan, 1980.
AB - Reviews the books, Violent Delinquents by Paul A. Strasburg (see record [rid]1980-50594-000[/rid]) and The Psychological World of the Juvenile Delinquent by Daniel Offer, Richard C. Marohn, and Eric Ostrov (1979). Both volumes, although courageous in trying to deal with one of the most difficult and frustrating groups of juvenile delinquents, seem to be of limited value. Both plead for programs, but do not adequately describe such programs or show how they can be implemented. Both focus around treatment and do not in any way look back to find out how the difficulties could have been prevented or identified earlier. Both give us limited understanding theoretically, and offer little new knowledge. Both tend to ignore or only casually refer to the family, the group, the community, the cultural milieu, and the social dynamics of delinquent behavior. Both seem symptomatic of how stuck we are in continuing our narrow preoccupations with either psychiatric or systems models, rather than using new frameworks- such as ecology, with wide-ranging community-based intervention techniques incorporating elements such as outreach, family work, special schooling, or employment- and integrating the knowledge we have to produce imaginative, carefully planned, well executed, and creatively evaluated programs aimed at preventing as well as treating the violent juvenile. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cultural milieu
KW - juvenile delinquents
KW - social dynamics
KW - violent juvenile
KW - community-based intervention
KW - 1980
KW - Juvenile Delinquency
KW - Male Delinquency
KW - Sociocultural Factors
KW - 1980
U2 - Strasburg, Paul A. (1978); Violent delinquents; 272 pp. $16.95. Sovereign Books, New York
U2 - Offer, Daniel; Marohn, Richard C.; Ostrov, Eric. (1979); The psychological world of the juvenile delinquent; 224 pp. $15.00. Basic Books, New York
DO - 10.1111/j.1939-0025.1980.tb03275.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - RAPOPORT, S. I.
AU - KLEE, W. A.
AU - PETTIGREW, K. D.
AU - OHNO, K.
T1 - Entry of Opioid Peptides into the Central Nervous System.
JO - Science
JF - Science
Y1 - 1980/01/04/
VL - 207
IS - 4426
M3 - Article
SP - 84
EP - 86
SN - 00368075
AB - Cerebrovascular permeability of four modified opioid peptides-[DAla²] methionine enkephalin amide, β-[D-Ala62,"14C-Homoarg69]lipotropin 61-69, α- [D-Ala²,'14C-Homoarg9]endorphin, and β-[u-Ala², 14C-Homoarg]endorphin -ranged from 1.4 to 3.9 x 10-6 centimeters per second in brain regions of the conscious rat. These significant permeabilities should allow the peptides to fill the extracellular brain space with a half time of 3 to 11 minutes, as a result of a step increase in plasma concentration of unbound peptide [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269368; RAPOPORT, S. I. 1; KLEE, W. A. 2; PETTIGREW, K. D. 3; OHNO, K. 4; Affiliations: 1: Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, Maryland 21224; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland; 3: Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center; Issue Info: 1/ 4/1980, Vol. 207 Issue 4426, p84; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYATT, RICHARD G.
AU - JAMES, WALTER D.
AU - BOHL, EDWARD H.
AU - THEIL, KENNETH W.
AU - SAIF, LINDA J.
AU - KALICA, ANTHONY R.
AU - GREENBERG, HARRY B.
AU - KAPIKIAN, ALBERT Z.
AU - CHANOCK, ROBERT M.
T1 - Human Rotavirus Type 2: Cultivation in vitro.
JO - Science
JF - Science
Y1 - 1980/01/11/
VL - 207
IS - 4427
M3 - Article
SP - 189
EP - 191
SN - 00368075
AB - A strain of type 2 human rotavirus (Wa) was grown to relatively high titer through 14 passages in primary cultures of African green monkey kidney (AGMK) cells. This passage series was initiated with virus that had been passaged 11 times serially in newborn gnotobiotic piglets. In contrast, virus present in the stool of patient Wa as well as virus from the first, second, or third passage in piglets could not be propagated successfully in African green monkey kidney cells. Prior to each passage in cell culture, the virus was treated with trypsin and the inoculated cultures were centrifuged at low speed. Cultivation of a type 2 human rotavirus should aid attempts to characterize this virus and to develop a means of immunoprophylaxis for a serious diarrheal disease of human infants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269401; WYATT, RICHARD G. 1; JAMES, WALTER D. 1; BOHL, EDWARD H. 2; THEIL, KENNETH W. 2; SAIF, LINDA J. 2; KALICA, ANTHONY R. 3; GREENBERG, HARRY B. 3; KAPIKIAN, ALBERT Z. 3; CHANOCK, ROBERT M. 3; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Ohio Agricultural Research and Development Center, Wooster 44691; 3: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 1/11/1980, Vol. 207 Issue 4427, p189; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HUANG, LI-YEN MAE
AU - BARKER, JEFFERY L.
T1 - Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian Neurons.
JO - Science
JF - Science
Y1 - 1980/01/11/
VL - 207
IS - 4427
M3 - Article
SP - 195
EP - 197
SN - 00368075
AB - Stereoisomers of the barbiturate anesthetic pentobarbital were applied to mouse spinal neurons growing in tissue culture. Intracellular recordings of neuronal membrane properties revealed that the (+) and (-) isomers caused direct changes in membrane potential and conductance on some but not all of the cells tested. The action of the (+) isomer was predominantly excitatory, whereas the (-) isomer produced predominantly inhibitory responses. The (-) isomer was considerably more effective in potentiating inhibitory responses to the transmitter gammaaminobutyric acid. The results show that pentobarbital has multiple effects on neuronal excitability and demonstrate the presence of stereospecific sites of barbiturate action on central neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269404; HUANG, LI-YEN MAE 1; BARKER, JEFFERY L. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/11/1980, Vol. 207 Issue 4427, p195; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chepelinsky, Ana Berta
AU - Gantt, Raymond
AU - Wivel, Nelson
T1 - Presence of RNA Methylases in Intracisternal A Particles Purified from a Mouse Plasma Cell Tumor.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/01/15/
VL - 103
IS - 2
M3 - Article
SP - 339
EP - 347
PB - Wiley-Blackwell
SN - 00142956
AB - Intracisternal A particles share several biochemical properties with RNA tumor viruses, including 70-S RNA, reverse transcriptase, and a group-specific protein. In addition they form by budding from cytoplasmic membranes. It has been shown previously that various purified RNA tumor viruses contain N2-guanine RNA methylase; purified A particles were tested to determine if they contained this activity as well. The results showed that instead of a single methylase, six methylases were associated with intracisternal A particles: a cytidine and a uridine methylase, two N2-guanine monomethylases, an N2,N2-dimethylguanine methylase and an adenine methylase. These enzymes were indistinguishable from the cellular enzymes when Escherichia coli tRNAPhe was used as an acceptor RNA and three were shown to have the identical specificity, i.e. N2-guanine methylases for positions 10 and 34 and methylation of adenine in position 73 of the tRNAPhe. The specific activity of the core-associated RNA methylases increased approximately twofold over the methylases of the intact particles, indicating that these methylases were associated with the internal structure and not simply adherent to the envelope surface. This suggests that these cellular enzymes are packaged within intracisternal A particles during synthesis. Thus, intracisternal A particles are similar to the oncornaviruses in that reverse transcriptase is the only known enzyme not of cellular origin, but they appear to contain cellular methylases not found in other RNA tumor viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOGENIC viruses
KW - RNA
KW - PROTEINS
KW - CELL membranes
KW - ENZYMES
KW - METHYLTRANSFERASES
N1 - Accession Number: 13602758; Chepelinsky, Ana Berta 1 Gantt, Raymond 1 Wivel, Nelson 1; Affiliation: 1: Laboratory of Cellular and Molecular Biology and Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 1/15/80, Vol. 103 Issue 2, p339; Subject Term: ONCOGENIC viruses; Subject Term: RNA; Subject Term: PROTEINS; Subject Term: CELL membranes; Subject Term: ENZYMES; Subject Term: METHYLTRANSFERASES; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moses, Alan C.
AU - Nissley, S. Peter
AU - Short, Patricia A.
AU - Rechler, Matthew M.
AU - Podskalny, Judy M.
T1 - Purification and Characterization of Multiplication-Stimulating Activity.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/01/15/
VL - 103
IS - 2
M3 - Article
SP - 387
EP - 400
PB - Wiley-Blackwell
SN - 00142956
AB - Multiplication-stimulating activity (MSA) refers to a family of insulin-like growth factors that have been purified from serum-free medium conditioned by a Buffalo rat liver cell line (BRL-3A). Using Dowex ion-exchange chromatography, gel chromatography on Sephadex G-75, and preparative disc acrylamide gel electrophoresis, several polypeptides with the full biological multiplication- stimulating activity have been isolated. One of these polypeptides, designated MSA II-1, previously has been used to study the relationship of the activity to the insulin-like growth factors (somatomedins) purified from human plasma. Polypeptide II-1 is a single chain polypeptide of molecular weight 8700. Glycine is the COOH-terminal amino acid. Edman degradation of carboxymethylated MSA II-1 did not reveal a free NH2-terminus. A polypeptide of lower molecular weight than MSA II-1 has also been purified. This polypeptide (MSA III-2) has been shown to be more potent than MSA II-1 in the rat-liver-membrane radioreceptor assay and in a competitive binding assay utilizing the rat-serum somatomedin-binding protein(s). The relationship of these various poly-peptides has been investigated by gel filtration in guanidine hydrochloride and by acrylamide gel electrophoresis of the reduced and native polypeptides. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GROWTH factors
KW - INSULIN
KW - LIVER cells
KW - CELL lines
KW - ION exchange chromatography
KW - PEPTIDES
KW - CARRIER proteins
N1 - Accession Number: 13602864; Moses, Alan C. 1 Nissley, S. Peter 1 Short, Patricia A. 1 Rechler, Matthew M. 1 Podskalny, Judy M. 1; Affiliation: 1: Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, and Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/80, Vol. 103 Issue 2, p387; Subject Term: GROWTH factors; Subject Term: INSULIN; Subject Term: LIVER cells; Subject Term: CELL lines; Subject Term: ION exchange chromatography; Subject Term: PEPTIDES; Subject Term: CARRIER proteins; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moses, Alan C.
AU - Nissley, S. Peter
AU - Short, Patricia A.
AU - Rechler, Matthew M.
T1 - Immunological Cross-reactivity of Multiplication-Stimulating Activity Polypeptides.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/01/15/
VL - 103
IS - 2
M3 - Article
SP - 401
EP - 408
PB - Wiley-Blackwell
SN - 00142956
AB - The immunoreactivity of the multiple species of multiplication-stimulating activity (MSA) purified from medium conditioned by a rat liver cell line (BRL-3A) has been examined. Antibodies were raised in rabbits following immunization with MSA II polypeptides. Subpopulations of anti- bodies were purified from one antiserum using DEAE-cellulose chromatography. One antibody subpopulation recognized common antigenic determinants on MSA I and MSA II polypeptides; whereas a second antibody subpopulation recognized common determinants on MSA I, II, and III polypeptides. In a radioimmunoassay utilizing 125I-MSA III-2 and a purified antibody subpopulation, the human somatomedins (somatomedin A, insulin-like growth factor I and II) showed weak, but significant cross-reactivity: insulin-like growth factor II was 10% as potent as MSA II. By contrast, somatomedin partially purified from rat serum, insulin, growth hormone, epidermal growth factor, nerve growth factor, and fibroblast growth factor, showed no reactivity in the radio-immunoassay. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER cells
KW - CELL lines
KW - IMMUNOGLOBULINS
KW - PEPTIDES
KW - GROWTH factors
KW - INSULIN
N1 - Accession Number: 13602877; Moses, Alan C. 1 Nissley, S. Peter 1 Short, Patricia A. 1 Rechler, Matthew M. 1; Affiliation: 1: Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland,a nd Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institute of Health, Bethesda, Maryland; Source Info: 1/15/80, Vol. 103 Issue 2, p401; Subject Term: LIVER cells; Subject Term: CELL lines; Subject Term: IMMUNOGLOBULINS; Subject Term: PEPTIDES; Subject Term: GROWTH factors; Subject Term: INSULIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tallman, John F.
AU - Paul, Steven M.
AU - Skolnick, Phil
AU - Gallager, Dorothy W.
T1 - Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines.
JO - Science
JF - Science
Y1 - 1980/01/18/
VL - 207
IS - 4428
M3 - Article
SP - 274
EP - 281
SN - 00368075
N1 - Accession Number: 85266201; Tallman, John F. 1; Paul, Steven M. 2; Skolnick, Phil 3; Gallager, Dorothy W. 1; Affiliations: 1: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Psychobiology Branch, National Institute of Mental Health; 3: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Maryland 20205; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p274; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MCCULLOCH, JAMES
AU - SAVAKI, HELEN E.
AU - MCCULLOCH, MAILIS C.
AU - SOKOLOFF, LOUIS
T1 - Retina-Dependent Activation by Apomorphine of Metabolic Activity in the Superficial Layer of the Superior Colliculus.
JO - Science
JF - Science
Y1 - 1980/01/18/
VL - 207
IS - 4428
M3 - Article
SP - 313
EP - 315
SN - 00368075
AB - Studies of the effects of the dopamine agonist apomorphine on local cerebral glucose utilization by means of the carbon-14-labeled deoxyglucose method demonstrate a dose-dependent metabolic activation in the superficial layer of the superior colliculus in the rat. Apomorphine stimulated glucose utilization in a number of other cerebral structures, but only the effect in the superficial layer of the superior colliculus depended on an intact retinal input. This effect was present with the animal in the light or in the dark, but was abolished by enucleation, which left the effects in other cerebral structures unimpaired. Activation of the superficial layer of the superior colliculus appears, therefore, to be secondary to an action of apomorphine on dopaminergic systems within the retina. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266224; MCCULLOCH, JAMES 1; SAVAKI, HELEN E. 1; MCCULLOCH, MAILIS C. 1; SOKOLOFF, LOUIS 1; Affiliations: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p313; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAKE, C. R.
AU - STERNBERG, D. E.
AU - VAN KAMMEN, D. P.
AU - BALLENGER, J. C.
AU - ZIEGLER, M. G.
AU - POST, R. M.
AU - KOPIN, I. J.
AU - BUNNEY, W. E.
T1 - Schizophrenia: Elevated Cerebrospinal Fluid Norepinephrine.
JO - Science
JF - Science
Y1 - 1980/01/18/
VL - 207
IS - 4428
M3 - Article
SP - 331
EP - 333
SN - 00368075
AB - Concentrations of norepinephrine in cerebrospinal fluid are higher in schizophrenic patients, particularly in those with paranoid features, than in normal volunteer subjects of the same age. This observation supports recent reports of elevated concentrations of norepinephrine in specific brain areas adjacent to the cerebral ventricles of paranoid schizophrenic patients. Overflow of the amine from periventricular regions into the cerebrospinal fluid may reflect abnormally high release or diminished enzymatic destruction of norepinephrine in patients with schizophrenia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266233; LAKE, C. R. 1; STERNBERG, D. E. 2; VAN KAMMEN, D. P. 2; BALLENGER, J. C. 2; ZIEGLER, M. G. 3; POST, R. M. 2; KOPIN, I. J. 3; BUNNEY, W. E. 3; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014; 2: Biological Psychiatry Branch, National Institute of Mental Health; 3: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 1/18/1980, Vol. 207 Issue 4428, p331; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Magnuson, R A
T1 - Project rmag: slang (structured language) compiler
JO - Rep. No: NIH-DCRT-DMB-SSS-UG105-80
JF - Rep. No: NIH-DCRT-DMB-SSS-UG105-80
Y1 - 1980/01/24/
M3 - Book Chapter
AB - Sporting its new name, this is the long-promised rmagasm in rmagasm. Designed to assist programmers writing powerful structured programs, the slang compiler generates block-structured ibm 370 assembly language source code. Based on some six years experience developing and using the rmag--implemented rmagasm compiler, slang retains the important features of its predecessor while adding some original, new ones of its own
N1 - Accession Number: ISTA1700615; Magnuson, R A 1; Affiliations: 1 : National Institutes Of Health, Bethesda, Md. Div. Of Computer Research And Technology; Source Info: Jan. 24, 1980; Note: Update Code: 1700; Number of Pages: 150p; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - HAGINS, W. A.
T1 - Near-Infrared Microscopy.
JO - Science
JF - Science
Y1 - 1980/01/25/
VL - 207
IS - 4429
M3 - Article
SP - 358
EP - 358
SN - 00368075
N1 - Accession Number: 85266235; HAGINS, W. A. 1; Affiliations: 1: Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/25/1980, Vol. 207 Issue 4429, following p358; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brownstein, Michael J.
AU - Russell, James T.
AU - Gainer, Harold
T1 - Synthesis, Transport, and Release of Posterior Pituitary Hormones.
JO - Science
JF - Science
Y1 - 1980/01/25/
VL - 207
IS - 4429
M3 - Article
SP - 373
EP - 378
SN - 00368075
N1 - Accession Number: 85266239; Brownstein, Michael J. 1; Russell, James T. 2; Gainer, Harold 2; Affiliations: 1: Member of the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Members of the Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda; Issue Info: 1/25/1980, Vol. 207 Issue 4429, p373; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Haynes, Suzanne G.
AU - Feinleib, Manning
T1 - Women, Work and Coronary Heart Disease: Prospective Findings from the Framingham Heart Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/02//
VL - 70
IS - 2
M3 - Article
SP - 133
PB - American Public Health Association
SN - 00900036
AB - Abstract: This study examined the relationship of employment status and employment-related behaviors to the incidence of corona,'y heart disease (CHD) in women. Between 1965 and 1967. a psychosocial questionnaire was administered to 350 housewives. 387 working women (women who had been employed outside the home over one-half their adult years), and 580 men participating in the Framingham Heart Study, The respondents were 45 to 64 years of age and were followed for the development of CHD over the ensuing eight years. Regardless of employment status, women reported signiticantly more symptoms of emotional distress than men. Working women and men were more likely to report Type A behavior, ambitiousness. and marital disagreements than were housewives: working women experienced more job mobility than men. and more daily stress and marital dissatisfaction than housewives or men. Working women did not have significantly higher incidence rates of CHD than housewives 17.8 vs 5.4 per ¢. respectively). However. CHD rates were it[most twice as great among women homing clerical jobs (10.6 per ¢) as compared to housewives. The most significant predictors of CHD among clerical workers were: suppressed hostility. having a nonsupportive boss. and decreased job mobility CHD rates were higher among working women who had ever married, especially among those who had raised three or more children. Among working women electrical workers who had children and were married blue collar workers were at highest risk of developing CHD [21.3 per ¢.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN employees
KW - HEART diseases in women
KW - CORONARY heart disease
KW - STRESS (Psychology)
KW - WOMEN -- Diseases
KW - WOMEN'S health services
KW - BLUE collar workers
KW - OCCUPATIONAL mobility
KW - RESEARCH
N1 - Accession Number: 4958499; Haynes, Suzanne G. 1 Feinleib, Manning 2; Affiliation: 1: Epidemiology Branch, National heart, Lung and Blood Institute, Federal Building, Room 2C08, Bethesda, MD 20205. 2: Associate Director, Epidemiology and Biometry Program, NHLBI.; Source Info: Feb1980, Vol. 70 Issue 2, p133; Subject Term: WOMEN employees; Subject Term: HEART diseases in women; Subject Term: CORONARY heart disease; Subject Term: STRESS (Psychology); Subject Term: WOMEN -- Diseases; Subject Term: WOMEN'S health services; Subject Term: BLUE collar workers; Subject Term: OCCUPATIONAL mobility; Subject Term: RESEARCH; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Agbata, A. I.
AU - Kirkpatrick, B. H.
T1 - Circulating immune complexes containing anti-VIII antibodies in multi-transfused patients with haemophilia A.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/02//
VL - 39
IS - 2
M3 - Article
SP - 315
EP - 320
PB - Wiley-Blackwell
SN - 00099104
AB - Evidence for the presence of circulating immune complexes was found in thirty-four out of fifty-five samples from forty-seven patients with haemophila A. In eleven patients the complexes, precipitated from the blood with polyethylene glycol, were digested with pepsin. The F(ab')2 antibody was tested, and found to have neutralizing activity against coagulant Factor VIII in two patients. In one of these no free antibody had ever been found in the plasma, while in the other the antibody was concentrated tenfold in the complex. In two other samples free without complexed antibody was found. In comparison, IgG-containing complexes were found in nine out of nineteen patients with von Wiliebrand's disease and no complexes were found in the sera from twelve multi-transfused thalassaemics. PEG precipitation is a useful technique for the preparation of concentrated immune complexes for further study such as antigen identification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE complexes
KW - HAEMOPHILUS
KW - POLYETHYLENE glycol
KW - PEPSIN
KW - IMMUNOGLOBULINS
KW - COAGULATION
KW - ANTIGENS
N1 - Accession Number: 15960828; Agbata, A. I. 1 Kirkpatrick, B. H. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1980, Vol. 39 Issue 2, p315; Subject Term: IMMUNE complexes; Subject Term: HAEMOPHILUS; Subject Term: POLYETHYLENE glycol; Subject Term: PEPSIN; Subject Term: IMMUNOGLOBULINS; Subject Term: COAGULATION; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fisher, R. I.
AU - Mandell, G. L.
AU - Bostick, Frieda
AU - Mcmenamin, Mary G.
AU - Anderson, T.
T1 - Chlorozotocin, an anti-tumour agent lacking bone marrow toxicity at therapeutic doses: effects on lymphocyte subpopulations in mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/02//
VL - 39
IS - 2
M3 - Article
SP - 416
EP - 425
PB - Wiley-Blackwell
SN - 00099104
AB - Chlorozotocin is a new nitrosourea anti-tumour drug that does not produce bone marrow suppression at therapeutic doses in mice. CDF1 mice which were injected i.p. with a dose lethal to 10% of animals within W days (LD10), 20 mg/kg, developed a 50% reduction in circulating peripheral blood lymphocytes without a decrease in circulating granulocytes by day 3. Spleen weight also decreased markedly. The percentage of spleen B and T cells, determined by immunofluorescence with goat anti-mouse IgG and rabbit anti-mouse brain antisera, did not differ in control and chlorozotocin-treated mice. However, the ability of residual spleen cells to proliferate in response to phytohaemagglutinin, concanavalin A, pokeweed mitogen, and allogeneic cells was significantly .suppressed although the lipopolysaccharide response was not reduced. The ability of the mice to respond to a primary immunization with sheep red blood cells was not significantly impaired. Therefore, chlorozotocin has a cytotoxic effect on both B and T cells but selectively inhibits the proliferative capacity of T cells. B cell proliferation and Ii cell function as measured in a primary antibody response were not reduced. These studies suggest chlorozotocin may be useful as an immunosuppressive drug as well as an anti-tumour agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITROSOUREAS
KW - BONE marrow
KW - TOXICITY testing
KW - LYMPHOCYTES
KW - IMMUNOFLUORESCENCE
KW - GRANULOCYTES
KW - T cells
KW - MITOGENS
N1 - Accession Number: 15960865; Fisher, R. I. 1 Mandell, G. L. 1 Bostick, Frieda 1 Mcmenamin, Mary G. 1 Anderson, T. 1; Affiliation: 1: Medicine Branch, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Feb1980, Vol. 39 Issue 2, p416; Subject Term: NITROSOUREAS; Subject Term: BONE marrow; Subject Term: TOXICITY testing; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOFLUORESCENCE; Subject Term: GRANULOCYTES; Subject Term: T cells; Subject Term: MITOGENS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HERKENHAM, MILES
T1 - Laminar Organization of Thalamic Projections to the Rat Neocortex.
JO - Science
JF - Science
Y1 - 1980/02//2/ 1/1980
VL - 207
IS - 4430
M3 - Article
SP - 532
EP - 535
SN - 00368075
AB - Nervefibers transmitting information from the thalamus to the cerebral cortex may be classified according to their major cortical layers of termination. (i) One class consists of inputs from thalamic relay nuclei for vision, audition, and somesthesis to layer IV, layer III, or both. In contrast, autoradiographic studies of projections from other thalamic nuclei reveal strikingly different patterns of termination: (ii) layer VI (or layer V, or both) is the target of fibers from the intralaminar nuclei, and (iii) layer I is the target forfibers from the ventromedial and magnocellular medial geniculate nuclei. (iv) The remaining class is typified by termination both in layer I and in additional layers that depend on the cortical area in which the terminations are found. The data demonstrate that convergent thalamic inputs to a given cortical area are usually not confluent within a layer and provide a newframework for categorizing thalamic nuclei. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266303; HERKENHAM, MILES 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/ 1/1980, Vol. 207 Issue 4430, p532; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2011-08324-007
AN - 2011-08324-007
AU - Silberman, Edward K.
AU - Post, Robert M.
T1 - The march of symptoms in a psychotic decompensation: Case report and theoretical implications.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/02//
VL - 168
IS - 2
SP - 104
EP - 110
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Post, Robert M., Section on Psychobiology, National Institute of Mental Health, Building 10, Room 3S239, 9000 Rockville Pike, Bethesda, MD, US, 20205
N1 - Accession Number: 2011-08324-007. PMID: 7354306 Partial author list: First Author & Affiliation: Silberman, Edward K.; Section on Psychobiology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110711. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Disease Course; Epilepsy; Major Depression; Psychosis; Symptoms. Minor Descriptor: Kindling; Seizures. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Tests & Measures: Bunney-Hamburg Scale-Modified version. Methodology: Clinical Case Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 1980. Copyright Statement: The Williams & Wilkins Co. 1980.
AB - The onset and evolution of symptoms were studied in a female patient with a history of recurrent depressive psychoses. In each episode, her psychotic decompensations were characterized by an orderly and progressive sequence including similar psychological or somatic precipitants, mounting anxiety, nystagmoid eye movements associated with panic, unfolding delusions, and olfactory hallucinations, culminating in a complete psychotic regression. The evolving sequence repeated during each episode in the present case is compared with that of a similarly stereotyped progression of symptoms in temporal lobe and Jacksonian seizures. Kindling is suggested as a model relevant to the understanding of both epilepsy and the functional psychoses. Detailed observation of the evolution of symptoms during psychotic episodes may provide important clues to the underlying pathological anatomy and physiology of psychotic illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recurrent depressive psychosis
KW - psychotic decompensation
KW - disease course
KW - symptom progression
KW - temporal lobe & Jacksonian seizures
KW - epilepsy
KW - kindling
KW - 1980
KW - Disease Course
KW - Epilepsy
KW - Major Depression
KW - Psychosis
KW - Symptoms
KW - Kindling
KW - Seizures
KW - 1980
DO - 10.1097/00005053-198002000-00007
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - PARLOFF, MORRIS B.
T1 - Appraising Psychotherapy.
JO - Science
JF - Science
Y1 - 1980/02/22/
VL - 207
IS - 4433
M3 - Article
SP - 823
EP - 823
SN - 00368075
N1 - Accession Number: 85361610; PARLOFF, MORRIS B. 1; Affiliations: 1: Psychotherapy and Behavioral Intervention Section, Clinical Research Branch, National Institute of Mental Health, Rockville, Maryland 20857; Issue Info: 2/22/1980, Vol. 207 Issue 4433, p823; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pickle, Linda W.
AU - Gottlieb, Marise S.
T1 - Pancreatic Cancer Mortality in Louisiana.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/03//
VL - 70
IS - 3
M3 - Article
SP - 256
EP - 259
PB - American Public Health Association
SN - 00900036
AB - As a preliminary step in the investigation of high pancreas-cancer mortality among White males in a cluster of Louisiana parishes, we examined 876 pairs of certificates of death which occurred in this area during 1960–75. The pancreas-cancer death records were matched to controls by age, race, sex, year of death, and parish of residence. The odds ratios were increased about two-fold for workers in the oil refining and paper manufacturing industries, and slight elevations were seen among residents near refineries and food processing plants. Despite the limited residential and occupational information available on death certificates, this study suggests leads to environmental factor that can be further investigated by a case-control interview study in Louisiana. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEATH
KW - PANCREATIC cancer
KW - PARISHES
KW - DEATH certificates
KW - INDUSTRIAL workers
KW - FOOD processing plants
KW - RESIDENTS
KW - MANUFACTURING industries
KW - LOUISIANA
N1 - Accession Number: 4957745; Pickle, Linda W. 1 Gottlieb, Marise S. 2; Affiliation: 1: Analytical Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205 2: Associate Professor, Tulane University School of Medicine, Department of Medicine and Epidemiology, Box D-55, 1430 Tulane Avenue, New Orleans, LA 70012; Source Info: Mar1980, Vol. 70 Issue 3, p256; Subject Term: DEATH; Subject Term: PANCREATIC cancer; Subject Term: PARISHES; Subject Term: DEATH certificates; Subject Term: INDUSTRIAL workers; Subject Term: FOOD processing plants; Subject Term: RESIDENTS; Subject Term: MANUFACTURING industries; Subject Term: LOUISIANA; NAICS/Industry Codes: 236210 Industrial Building Construction; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Presser, Harriet B.
AU - Baldwin, Wendy
T1 - Child Care as a Constraint on Employment: Prevalence, Correlates, and Bearing on the Work and Fertility Nexus.
JO - American Journal of Sociology
JF - American Journal of Sociology
Y1 - 1980/03//
VL - 85
IS - 5
M3 - Article
SP - 1202
EP - 1213
SN - 00029602
AB - Women with small children, especially the young, black, single, poor, or poorly educated, are constrained from seeking or taking employment because of the lack of child care facilities.
KW - CHILD care
KW - MOTHERS -- Employment
KW - MOTHER & child
KW - LABOR supply
KW - LABOR market
KW - HUMAN fertility
KW - WOMEN
KW - EMPLOYMENT (Economic theory)
N1 - Accession Number: 15595638; Presser, Harriet B. 1; Baldwin, Wendy 2; Affiliations: 1 : Community College of Rhode Island, Newport; 2 : Center for Population Research, National Institute of Child Health and Human Development; Source Info: Mar80, Vol. 85 Issue 5, p1202; Historical Period: 1977; Subject Term: CHILD care; Subject Term: MOTHERS -- Employment; Subject Term: MOTHER & child; Subject Term: LABOR supply; Subject Term: LABOR market; Subject Term: HUMAN fertility; Subject Term: WOMEN; Subject Term: EMPLOYMENT (Economic theory); Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Snippe, H.
AU - Willers, J. M. N.
AU - Inman, J. K.
AU - Merchant, B.
T1 - The specificity of antibody formation in mice following immunization with hapten-carrier complexes mixed with the surfactant, dimethyl dioctadecyl ammonium bromide.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 361
EP - 366
PB - Wiley-Blackwell
SN - 00192805
AB - Mice were immunized i.e. with various enlarged haptens conjugated to bovine serum albumin and mixed with the cationic, surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA). This immunization generated delayed-type hypersensitivity (DH) in these mice without detectable concomitant antibody formation. The DH was measured as footpad swelling. However, both direct and indirect hapten-specific PFC could be detected in peripheral lymph nodes and in spleens 4 days after a challenge injection. Although the adjuvant, DDA, promotes a strong cross-reactivity in DH between heterologous hapten--carrier complexes, the antibody-forming cells produced 4 days after challenge showed relatively high specificity for the immunizing hapten. This indicates only weak cross-reactivity at the anti-body-forming cell level co-existent with high cross-reactivity in DH expression to the same hapten-carrier complexes. These results are consistent with the possibility that B-cell receptors may be capable of expressing a greater degree of hapten specificity than T-cell receptors. It is tentatively concluded that Thelper cells participating in antibody formation may represent a subset of the T cells involved in DH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOGLOBULINS
KW - HAPTENS
KW - SURFACE active agents
KW - SERUM albumin
KW - MICE as laboratory animals
N1 - Accession Number: 13520411; Snippe, H. 1 Willers, J. M. N. 1 Inman, J. K. 2 Merchant, B. 3; Affiliation: 1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands. 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health. 3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p361; Subject Term: IMMUNIZATION; Subject Term: IMMUNOGLOBULINS; Subject Term: HAPTENS; Subject Term: SURFACE active agents; Subject Term: SERUM albumin; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stevenson, H. C.
AU - Fauci, A. S.
T1 - Activation of human B lymphocytes XII. DIFFERENTIAL EFFECTS OF IN VITRO CYCLOPHOSPHAMIDE ON HUMAN LYMPHOCYTE SUBPOPULATIONS INVOLVED IN B-CELL ACTIVATION.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 391
EP - 397
PB - Wiley-Blackwell
SN - 00192805
AB - The differential effects of in vitro cyclophosphamide (CY) on subpopulations of normal human peripheral blood lymphocytes involved in the pokeweed mitogen-induced plaque-forming cell (PFC) response against sheep red blood cells were examined. It was found that the plaque-forming B cells in this system are sensitive to CY over a wide concentration range including concentrations which have a minimal effect on overall cell viability. Kinetic experiments revealed that CY exerts its inhibitory effect on the PFC response only if added very early in culture. Thus, it appears that in vitro CY must exert its inhibitory influence on an early phase of polyclonal B-cell activation. When T-cell enriched (TCE) populations were incubated overnight with high concentration CY and then added back in co-culture to fresh autologous B cells, significant enhancement of PFC responses was observed suggesting a selective inhibition or elimination of a regulatory suppressor cell population found in ICE lymphocyte preparations. Helper T cells are relatively resistant to the inhibitory actions of CY. Thus, human B cells appear to be most sensitive to CY, followed in sensitivity by the suppressor cell populations in the 1-cell fraction with relative resistance of the helper T cells. These observations have direct relevance in understanding the mechanisms of selective action of CY on normal human lymphocyte subpopulations with possible application to disease states in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - CELL culture
KW - IMMUNOLOGY
KW - CYTOLOGY
KW - MITOGENS
KW - T cells
N1 - Accession Number: 13520516; Stevenson, H. C. 1 Fauci, A. S. 1; Affiliation: 1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p391; Subject Term: LYMPHOCYTES; Subject Term: CELL culture; Subject Term: IMMUNOLOGY; Subject Term: CYTOLOGY; Subject Term: MITOGENS; Subject Term: T cells; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katz, P.
AU - Fauci, A. S.
T1 - Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: killing of human erythrocytes and autologous lymphoid cells.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 407
EP - 416
PB - Wiley-Blackwell
SN - 00192805
AB - The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin lgG (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while I cells with surface Fc receptors for IgM (TM) displayed no ADCC activity TG-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBODY-dependent cell cytotoxicity
KW - LYMPHOCYTES
KW - ERYTHROCYTES
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGY
KW - CELL receptors
N1 - Accession Number: 13520670; Katz, P. 1 Fauci, A. S. 1; Affiliation: 1: Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Bethesda. Maryland U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p407; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: LYMPHOCYTES; Subject Term: ERYTHROCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGY; Subject Term: CELL receptors; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - King, Haitung
AU - Locke, Frances B.
T1 - Chinese in the United States: A Century of Occupational Transition.
JO - International Migration Review
JF - International Migration Review
Y1 - 1980///Spring1980
VL - 14
IS - 1
M3 - Article
SP - 15
EP - 42
SN - 01979183
AB - Examines the occupational roles assumed by Chinese Americans over the past century and assesses the degree to which these were dictated by legal and socioeconomic barriers.
KW - OCCUPATIONS
KW - CAREER development
KW - SOCIOECONOMICS
KW - SOCIOLOGY
KW - HEALTH status indicators
KW - ENTREPRENEURSHIP
KW - SOCIAL structure
KW - LAW
KW - ECONOMIC history
KW - CHINESE Americans
N1 - Accession Number: 16484939; King, Haitung 1; Locke, Frances B. 2; Affiliations: 1 : National Cancer Institute And Georgetown University.; 2 : National Cancer Institute.; Source Info: Spring1980, Vol. 14 Issue 1, p15; Historical Period: 1870 to 1980; Subject Term: OCCUPATIONS; Subject Term: CAREER development; Subject Term: SOCIOECONOMICS; Subject Term: SOCIOLOGY; Subject Term: HEALTH status indicators; Subject Term: ENTREPRENEURSHIP; Subject Term: SOCIAL structure; Subject Term: LAW; Subject Term: ECONOMIC history; Subject Term: CHINESE Americans; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - GEN
AU - Hearing, Vincent J.
T1 - TYROSINASE HYDROXYLATION.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/03//
VL - 74
IS - 3
M3 - Letter
SP - 183
EP - 183
SN - 0022202X
AB - Presents a letter to the editor about incapability of mammalian tyrosinase of tyrosine hydroxylation.
KW - LETTERS to the editor
KW - PHENOL oxidase
N1 - Accession Number: 12535096; Hearing, Vincent J. 1; Affiliation: 1: Senior Investigator Dermatology Branch National Cancer Institute.; Source Info: Mar1980, Vol. 74 Issue 3, p183; Subject Term: LETTERS to the editor; Subject Term: PHENOL oxidase; Number of Pages: 1/2p; Document Type: Letter
L3 - 10.1111/1523-1747.ep12535096
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tarone, Robert E.
AU - Gart, John J.
T1 - On the Robustness of Combined Tests for Trends in Proportions.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1980/03//
VL - 75
IS - 369
M3 - Article
SP - 110
SN - 01621459
AB - Several models with monotone trend in proportions are considered for 2 x I x J contingency tables. For one stratum (I = 1) and broad regularity conditions, the C(alpha) test statistic for testing for trend is shown to be fully efficient for all choices of the model with monotone trend. For several strata, the efficiency of each C(alpha) test is compared with the efficiency of the C(alpha) test appropriate when each of the other models holds. These relative efficiencies are used for choosing the most robust tests in a variety of sampling situations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICS
KW - DISTRIBUTION (Probability theory)
KW - ECONOMIC trends
KW - SAMPLING (Statistics)
KW - MATHEMATICAL statistics
KW - PROBABILITY theory
KW - STATISTICAL hypothesis testing
KW - CONTINGENCY tables
KW - 2× J contingency tables.
KW - C(α) test statistics
KW - Pitman asymptotic relative efficiencies
N1 - Accession Number: 4599761; Tarone, Robert E. 1; Gart, John J. 2; Affiliations: 1: Mathematical Statistician, Biometry Branch, National Cancer Institute, Landow Building, Room 5C25, Bethesda, MD 20205.; 2: Head, Mathematical Statistics and Applied Mathematics Section, Biometry Branch, National Cancer Institute, Landow Building, Room 5C25, Bethesda, MD 20205.; Issue Info: Mar1980, Vol. 75 Issue 369, p110; Thesaurus Term: STATISTICS; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: ECONOMIC trends; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: CONTINGENCY tables; Author-Supplied Keyword: 2× J contingency tables.; Author-Supplied Keyword: C(α) test statistics; Author-Supplied Keyword: Pitman asymptotic relative efficiencies; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2011-08325-011
AN - 2011-08325-011
AU - Goldberg, Solomon C.
AU - Eckert, Elke D.
AU - Casper, Regina C.
AU - Halmi, Katherine A.
AU - Davis, John M.
AU - Roper, Margaret T.
T1 - Factors influencing hospital differences in weight gain in anorexia nervosa.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/03//
VL - 168
IS - 3
SP - 181
EP - 183
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Goldberg, Solomon C., Department of Psychiatry, Medical College of Virginia, MCV Station 710, Richmond, VA, US, 23298
N1 - Accession Number: 2011-08325-011. PMID: 7354320 Partial author list: First Author & Affiliation: Goldberg, Solomon C.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110801. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Anorexia Nervosa; Hospitals; Prognosis; Treatment; Weight Gain. Minor Descriptor: Experience Level. Classification: Eating Disorders (3260); Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Mar, 1980. Copyright Statement: Williams & Wilkins Co. 1980.
AB - In a study of 105 anorexia nervosa patients, large hospital differences were found in weight gain which corresponded exactly to the amount of experience that each hospital had had in treating this disorder, and also corresponded to the degree of milieu structure imposed by each hospital. A further hypothesis to account for the hospital differences was in terms of the prognostic quality of the patients recruited to each hospital. To test the latter hypothesis, a number of prognostic indicators which had already been shown to be related to weight gain were statistically controlled by means of partial correlation. When this was done, the large hospital differences vanished, indicating that they were indeed a function of the qualities the patients brought with them to the hospital rather than what the hospital and its staff did to the patients. The results also indicate that the more experienced investigators seem to be able to recruit patients with better prognoses, whereas the less experienced ones are referred other clinicians' treatment failures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospital differences
KW - weight gain
KW - anorexia nervosa
KW - experience
KW - prognosis
KW - treatment
KW - 1980
KW - Anorexia Nervosa
KW - Hospitals
KW - Prognosis
KW - Treatment
KW - Weight Gain
KW - Experience Level
KW - 1980
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH-26218; MH- 26409; MH-26310. Recipients: No recipient indicated
DO - 10.1097/00005053-198003000-00011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08325-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08325-018
AN - 2011-08325-018
AU - Eckardt, Michael J.
T1 - Review of The hippocampus as a cognitive map.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/03//
VL - 168
IS - 3
SP - 191
EP - 192
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 2011-08325-018. Partial author list: First Author & Affiliation: Eckardt, Michael J.; National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, US. Release Date: 20110801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Maps; Hippocampus. Minor Descriptor: Anatomy; Behavior; Neurobiology; Physiology; Semantics. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: John, Okeefe; Lynn, Nadel. The hippocampus as a cognitive map=Oxford University Press, New York, xiv + 570 pp. $30.00; 1978. Page Count: 2. Issue Publication Date: Mar, 1980. Copyright Statement: Williams & Wilkins Co. 1980.
AB - Reviews the book, The hippocampus as a cognitive map by Okeefe John and Nadel Lynn (1978). The authors have reviewed the anatomy, physiology, and behavior associated with the hippocampus. The authors postulate that the hippocampus is functionally different from most other areas of the brain in that it has an innate capability of representing. The next section of the book consists of brief and, in general, excellent reviews of the anatomy and physiology of the hippocampus. The remainder of the book is devoted to showing that the spatiotemporal mapping function proposed for the hippocampus can be used to predict behavioral changes associated with hippocampal dysfunction. Finally, behavioral performance in humans with presumed damage to the hippocampus is examined, and the authors conclude that semantic mapping is conducted in the left hippocampus, whereas the spatial mapping system postulated for infrahuman is located in the right hippocampus. This book should be of widespread interest because of its incorporation of information from a number of different disciplines including philosophy, neurobiology, and psychology into a novel theory of how a clinically relevant brain structure works. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hippocampus
KW - cognitive maps
KW - neurobiology
KW - semantics
KW - anatomy
KW - physiology
KW - behavior
KW - spatiotemporal mapping
KW - 1980
KW - Cognitive Maps
KW - Hippocampus
KW - Anatomy
KW - Behavior
KW - Neurobiology
KW - Physiology
KW - Semantics
KW - 1980
U2 - John, Okeefe; Lynn, Nadel. (1978); The hippocampus as a cognitive map; Oxford University Press, New York, xiv + 570 pp. $30.00
DO - 10.1097/00005053-198003000-00018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08325-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - NORDEN, BETH
AU - BATRA, SUZANNE W. T.
AU - FALES, HENRY M.
AU - HEFETZ, ABRAHAM
AU - SHAW, G. JOHN
T1 - Anthophora Bees: Unusual Glycerides from Maternal Dufour's Glands Serve as Larval Food and Cell Lining.
JO - Science
JF - Science
Y1 - 1980/03/07/
VL - 207
IS - 4435
M3 - Article
SP - 1095
EP - 1097
SN - 00368075
AB - The Dufour's gland of Anthophora abrupta, a solitary bee, secretes a complex mixture of liquid triglycerides containing one long-chain and two shortchain fatty acids. This is applied inside the earthen brood cells and added to the provision, where it is converted, perhaps by enzymes from the bee's saliva or gut, to solid diglycerides that are later eaten by the bee larvae. This use of Dufour's gland secretion as food and its nutritive function are reminiscent of the royaljelly secreted by honey bees. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266482; NORDEN, BETH 1; BATRA, SUZANNE W. T. 2; FALES, HENRY M. 3; HEFETZ, ABRAHAM 3; SHAW, G. JOHN 4; Affiliations: 1: Department of Biological Sciences, Towson State University, Towson, Maryland 21204; 2: Beneficial Insect Introduction Laboratory, Department of Agriculture, Beltsville, Maryland 20705; 3: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 4: Borriston Research Laboratory, Temple Hills, Maryland 20031; Issue Info: 3/ 7/1980, Vol. 207 Issue 4435, p1095; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - OSKARSSON, MARIANNE
AU - MCCLEMENTS, WILLIAM L.
AU - BLAIR, DONALD G.
AU - MAIZEL, J. V.
AU - VANDE WOUDE, GEORGE F.
T1 - Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1980/03/14/
VL - 207
IS - 4436
M3 - Article
SP - 1222
EP - 1224
SN - 00368075
AB - A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balbic genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage λ. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196084; OSKARSSON, MARIANNE 1; MCCLEMENTS, WILLIAM L. 1; BLAIR, DONALD G. 2; MAIZEL, J. V. 3; VANDE WOUDE, GEORGE F. 4; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Viral Carcinogenesis, National Cancer Institute; 3: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 4: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 3/14/1980, Vol. 207 Issue 4436, p1222; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Felber, Barbara K.
AU - Maurhofer, Susanne
AU - Jaggi, Rolf B.
AU - Wyler, Toni
AU - Wahli, Walter
AU - Ryffel, Gerhart U.
AU - Weber, Rudolf
T1 - Isolation and Translation in vitro of Four Related Vitellogenin mRNAs of Estrogen-Stimulated Xenopus laevis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/03/15/
VL - 105
IS - 1
M3 - Article
SP - 17
EP - 24
PB - Wiley-Blackwell
SN - 00142956
AB - Cloning of vitellogenin cDNA of Xenopus laevis revealed that vitellogenin is encoded in a small family of genes representing two distantly related main groups A and B, each comprising two more closely related subgroups A1, A2, and B1, B2 respectively. To characterize the proteins derived from these genes we have isolated the corresponding mRNAs by hybridizing, under stringent conditions, cytoplasmic poly(A)-containing RNA from the liver of estrogen-stimulated Xenopus to filter-bound cDNA clones containing sequences specific for all four vitellogenin genes. Hybridization of the isolated mRNAs with nick-translated cDNA clones revealed that contamination of the mRNAs by those of the other main group was less than 0.1%. Melting curves of the hybrids prepared with the isolated mRNAs and cDNA clones specific for the four vitellogenin genes showed that the isolated vitellogenin mRNAs are also specific for the four subgroups. Analysis of R loops formed between isolated mRNAs and cDNA clones representing the corresponding subgroup further indicated about 10% cross-contamination between the more closely related mRNAs. In a reticulocyte lysate each of the four mRNAs coded for a 200000-Mr protein immuno- precipitable by monospecific vitellogenin antibody. From these results we conclude that the four different mRNAs A1, A2, B1 and B2, which all can be isolated efficiently, code for vitellogenin and are expressed simultaneously in response to estrogen stimulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESSENGER RNA
KW - XENOPUS laevis
KW - ESTROGEN
KW - ANTISENSE DNA
KW - PROTEINS
KW - NUCLEOTIDE sequence
KW - GENES
N1 - Accession Number: 13483547; Felber, Barbara K. 1 Maurhofer, Susanne 1 Jaggi, Rolf B. 1 Wyler, Toni 1 Wahli, Walter 1 Ryffel, Gerhart U. 1 Weber, Rudolf 1; Affiliation: 1: Division of Cell and Development Biology, Department of Zoology, University of Bern, and Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland; Source Info: 3/15/80, Vol. 105 Issue 1, p17; Subject Term: MESSENGER RNA; Subject Term: XENOPUS laevis; Subject Term: ESTROGEN; Subject Term: ANTISENSE DNA; Subject Term: PROTEINS; Subject Term: NUCLEOTIDE sequence; Subject Term: GENES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TALBOT, BERNARD
T1 - New Recombinant DNA Guidelines.
JO - Science
JF - Science
Y1 - 1980/03/21/
VL - 207
IS - 4437
M3 - Article
SP - 1296
EP - 1296
SN - 00368075
N1 - Accession Number: 85196089; TALBOT, BERNARD 1; Affiliations: 1: Office, Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1296; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VENTER, J. CRAIG
AU - FRASER, CLAIRE M.
AU - HARRISON, LEN C.
T1 - Autoantibodies to β2-Adrenergic Receptors: A Possible Cause of Adrenergic Hyporesponsiveness in Allergic Rhinitis and Asthma.
JO - Science
JF - Science
Y1 - 1980/03/21/
VL - 207
IS - 4437
M3 - Article
SP - 1361
EP - 1363
SN - 00368075
AB - Autoaintibodies to β2-adrenergic receptors have been identified in the seruinm of one patient with allergic rhinitis (''hay fever'" and two patients with asthma. The aintibodies precipitate solubilized dog luing βreceptors in an indirect iminunoprecipitation assay and inhibit the specific binding of todine-125-labeled iodohydroxybenzylpindolol to membrane-associated receptors fromn dog lung, calf lung, and humaon placenta. Ligand binding to canine heart β, receptors is not affected by the anitibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196100; VENTER, J. CRAIG 1; FRASER, CLAIRE M. 1; HARRISON, LEN C. 2; Affiliations: 1: Department of Pharmacology and Therapeutics, School of Medicine, State University of New York, Buffalo 14214; 2: Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1361; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAPPÉ, DONALD L.
AU - LAKATTA, EDWARD G.
T1 - Intensity Fluctuation Spectroscopy Monitors Contractile Activation in "Resting" Cardiac Muscle.
JO - Science
JF - Science
Y1 - 1980/03/21/
VL - 207
IS - 4437
M3 - Article
SP - 1369
EP - 1371
SN - 00368075
AB - Intensity flutctations in a laser beam by scattered by nonibeatinig isolatecd rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect and interaction of calcium with the myofilaments. The demonstration that both a portion of resting force and the frequiency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196103; LAPPÉ, DONALD L. 1; LAKATTA, EDWARD G. 1; Affiliations: 1: Cardiovascular Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224; Issue Info: 3/21/1980, Vol. 207 Issue 4437, p1369; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SERABJIT-SINGH, COSETTE J.
AU - WOLF, C. ROLAND
AU - PHILPOT, RICHARD M.
AU - PLOPPER, CHARLES G.
T1 - Cytochrome P-450: Localization in Rabbit Lung.
JO - Science
JF - Science
Y1 - 1980/03/28/
VL - 207
IS - 4438
M3 - Article
SP - 1469
EP - 1470
SN - 00368075
AB - Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and severalextrahepatic tissues of mammals, including humans. A form of cytochrome P450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266513; SERABJIT-SINGH, COSETTE J. 1; WOLF, C. ROLAND 1; PHILPOT, RICHARD M. 1; PLOPPER, CHARLES G. 2; Affiliations: 1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: Laboratory of Pulmonary Function and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park; Issue Info: 3/28/1980, Vol. 207 Issue 4438, p1469; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cutter, Gary
AU - Heyden, Siegfried
AU - Kasteler, Josephine
AU - Kraus, Jess F.
AU - Lee, Eun Sul
AU - Shipley, Thomas
AU - Stromer, Mitchell
AU - Mba
T1 - Mortality Surveillance in Collaborative Trials.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/04//
VL - 70
IS - 4
M3 - Article
SP - 394
PB - American Public Health Association
SN - 00900036
AB - Abstract: The Hypertension Detection and Follow-Up Program (HDFP) carried out two pilot surveillances covering the enumerated population to test procedures to be used in assessing the ability of the program to influence life expectancy in the total population. A rigorously sequenced pilot survey of 2,611 households was conducted and carefully monitored through two mailings, telephone contacts, home visits, and communication with "contact" persons. The response rates at each stage varied among the 13 centers. Overall, there was a 42.7 per ¢ yield from the first mailing, 42.5 per ¢ of those receiving a second mailing was completed; 78.0 per ¢ for telephone 61.3 per ¢ for the home visits and 55.2 per ¢ from the "contact" persons. Overall, 97.4 per ¢ of all persons had vital status ascertained. The second phase relaxed the rigorous sequential survey requirements and reduced the reporting requirements from every ten days to monthly. Overall, 93.3 per ¢ were successfully ascertained. Reduced survey structure, slightly increased mobility (from 12 per ¢ to 13 per ¢), increased workload from 200 to 400 households per center, and a longer time interval between initial enumeration and the mortality ascertainment are among the reasons for performance decline. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOUSEHOLD surveys
KW - MORTALITY -- Statistics
KW - HYPERTENSION
KW - PATIENTS
KW - LIFE expectancy
KW - HEALTH surveys
KW - DEMOGRAPHY
KW - POPULATION research
KW - TELEPHONE surveys
KW - MAILING lists (Lists of addresses)
N1 - Accession Number: 4952932; Cutter, Gary 1 Heyden, Siegfried 1 Kasteler, Josephine 1 Kraus, Jess F. 1 Lee, Eun Sul 1 Shipley, Thomas 1 Stromer, Mitchell 1 Mba; Affiliation: 1: Scientific Project Officer, Hypertension Detection and Follow-Up Program, DHVD, National Heart, Lung, and Blood Institute, NIH, Room 6C08, Federal Building, 7550 Wisconsin Avenue, Bethesda, MD 20205.; Source Info: Apr1980, Vol. 70 Issue 4, p394; Subject Term: HOUSEHOLD surveys; Subject Term: MORTALITY -- Statistics; Subject Term: HYPERTENSION; Subject Term: PATIENTS; Subject Term: LIFE expectancy; Subject Term: HEALTH surveys; Subject Term: DEMOGRAPHY; Subject Term: POPULATION research; Subject Term: TELEPHONE surveys; Subject Term: MAILING lists (Lists of addresses); NAICS/Industry Codes: 511140 Directory and Mailing List Publishers; NAICS/Industry Codes: 541860 Direct Mail Advertising; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagel, James E.
T1 - IMMUNOGLOBULIN SYNTHESIS.
JO - BioScience
JF - BioScience
Y1 - 1980/04//
VL - 30
IS - 4
M3 - Book Review
SP - 263
EP - 263
SN - 00063568
AB - The article reviews the book "Cells of Immunoglobulin Synthesis," edited by Benvenuto Pernis and Henry J. Vogel.
KW - Immunoglobulins
KW - Nonfiction
KW - Pernis, Benvenuto
KW - Vogel, Henry J.
KW - Cells of Immunoglobulin Synthesis (Book)
N1 - Accession Number: 28049114; Nagel, James E. 1; Affiliations: 1 : National Institute on Aging Gerontology Research Center Baltimore City Hospitals Baltimore, MD 21224; Source Info: Apr1980, Vol. 30 Issue 4, p263; Subject Term: Immunoglobulins; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 464
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Giambra, Leonard M.
T1 - A FACTOR ANALYSIS OF THE ITEMS OF THE IMAGINAL PROCESSES INVENTORY.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1980/04//
VL - 36
IS - 2
M3 - Article
SP - 383
EP - 409
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article focuses on the Imaginal Processes Inventory (IPI). The Imaginal Processes inventory consists of two parts. In Part I are 24 items that deal with day- and night-dreaming frequency or propensity. All items contain five alternatives, which implies a quantitative continuum that is not identical for all items of Part I. Furthermore, items that appear to have little or no relation to any of the major dimensions of mental processes measured by the IPI could be dropped, which would result in a much-needed shortened form.
KW - SLEEP disorders
KW - MENTAL illness
KW - FACTOR analysis
KW - CORRELATION (Statistics)
KW - PATH analysis (Statistics)
KW - INVENTORIES
N1 - Accession Number: 15829167; Giambra, Leonard M. 1; Affiliation: 1: Gerontology Research Center (Baltimore), National Institute on Aging, and National Institutes of Health, Department of Health Education and Welfare, Bethesda, and the Baltimore City Hospitals.; Source Info: Apr1980, Vol. 36 Issue 2, p383; Subject Term: SLEEP disorders; Subject Term: MENTAL illness; Subject Term: FACTOR analysis; Subject Term: CORRELATION (Statistics); Subject Term: PATH analysis (Statistics); Subject Term: INVENTORIES; Number of Pages: 27p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hintner, Helmut
AU - Fritsch, Peter I.
AU - Foidart, Jean-Michel
AU - Stingl, Georg
AU - Schuler, Gerold
AU - Katz, Stephen I.
T1 - Expression of Basement Membrane Zone Antigens at the Dermo-epibolic Junction in Organ Cultures of Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/04//
VL - 74
IS - 4
M3 - Article
SP - 200
EP - 204
SN - 0022202X
AB - Using the epithelial outgrowth in organ cultures of human skin ("epiboly") as a model system for basement membrane zone neogenesis, the emergence of various antigenic determinants of the junction zone (bullous pemphigoid antigen, type IV collagen and laminin) was studied and the time sequence of their appearance assessed. All 3 antigens were found at the newly built dermo-epibolic junction; their synthesis, however, followed a distinct time sequence: bullous pemphigoid antigens emerged synchronously with the advancing tip of the migrating epithelium, whereas type IV collagen and to a greater extent, laminin, appeared with considerable delay. At the ultrastructural level, the formation of basal lamina accompanied the emergence of type LV collagen and laminin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - CONNECTIVE tissues
KW - EPITHELIUM
KW - COLLAGEN
N1 - Accession Number: 12541715; Hintner, Helmut 1 Fritsch, Peter I. 1 Foidart, Jean-Michel 2,3 Stingl, Georg 1 Schuler, Gerold 1 Katz, Stephen I. 2,3; Affiliation: 1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 2: Dermatology Branch, National Cancer Institute and Laboratory of Developmental Biology and Anomalies, Bethesda, Maryland, U.S.A. 3: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr80, Vol. 74 Issue 4, p200; Subject Term: SKIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: CONNECTIVE tissues; Subject Term: EPITHELIUM; Subject Term: COLLAGEN; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12541715
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 1981-11025-001
AN - 1981-11025-001
AU - Windle, Charles
T1 - Correlates of community mental health center underservice to non-Whites.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 1980/04//
VL - 8
IS - 2
SP - 140
EP - 146
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
N1 - Accession Number: 1981-11025-001. PMID: 10245917 Partial author list: First Author & Affiliation: Windle, Charles; National Institute of Mental Health, Rockville, MD. Release Date: 19810501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Community Mental Health Centers; Community Mental Health Services; Demographic Characteristics; Help Seeking Behavior. Minor Descriptor: Blacks; Racial and Ethnic Groups. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 7. Issue Publication Date: Apr, 1980.
AB - Examined the relationships between relatively low utilization rates for non-Whites and catchment area demography center service characteristics for 142 federally funded community mental health centers. Center characteristics were less strongly related to relative utilization by non-Whites than were area demographic characteristics. Several characteristics of the Black population were among those most highly associated with relative non-White utilization rates. (6 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - demographic characteristics of catchment areas & characteristics of center's services
KW - community mental health center underservice to non-Whites
KW - 1980
KW - Client Characteristics
KW - Community Mental Health Centers
KW - Community Mental Health Services
KW - Demographic Characteristics
KW - Help Seeking Behavior
KW - Blacks
KW - Racial and Ethnic Groups
KW - 1980
DO - 10.1002/1520-6629(198004)8:2<140::AID-JCOP2290080207>3.0.CO;2-T
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42212-025
AN - 2013-42212-025
AU - Shore, Milton F.
T1 - Review of The mental health interview: Research and application.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1980/04//
VL - 50
IS - 2
SP - 376
EP - 376
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42212-025. Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Demographic Characteristics; Diagnosis; Interviews; Mental Health; Social Class. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Pope, Benjamin. The mental health interview: Research and application=540 pp. $40.00 Pergamon Press, Elmsford, NY; 1979. Page Count: 1. Issue Publication Date: Apr, 1980.
AB - Reviews the book, The Mental Health Interview: Research and Application by Benjamin Pope (1979). The purpose is well accomplished. Pope has produced an impressive, erudite, comprehensive resource book of current research knowledge on the mental health interview both in assessment and treatment. The research is described in detail in the 500 pages and is divided into areas of communication, relationship , demographic variables (in interviewer and interviewee, including sex, race, and social class), and temporary and sequential effects. The volume can certainly criticize the reader to the interactional experts of interviews. Rut although the author’s scholarship is evident, his own language and the minor attention to diagnostic categories, as well as minimal discussion of practice issues, limit the book’s value to the practitioner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - demographic variables
KW - diagnostic categories
KW - mental health interview
KW - research knowledge
KW - social class
KW - 1980
KW - Demographic Characteristics
KW - Diagnosis
KW - Interviews
KW - Mental Health
KW - Social Class
KW - 1980
U2 - Pope, Benjamin. (1979); The mental health interview: Research and application; 540 pp. $40.00 Pergamon Press, Elmsford, NY
DO - 10.1037/h0098884
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GALLAGER, DOROTHY W.
AU - MALLORGA, PIERRE
T1 - Diphenylhydantoin: Pre- and Postnatal Administration Alters Diazepam Binding in Developing Rat Cerebral Cortex.
JO - Science
JF - Science
Y1 - 1980/04/04/
VL - 208
IS - 4439
M3 - Article
SP - 64
EP - 66
SN - 00368075
AB - Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85136771; GALLAGER, DOROTHY W. 1; MALLORGA, PIERRE 1; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 4/ 4/1980, Vol. 208 Issue 4439, p64; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - J. CRANE, MARK ST.
AU - DVORAK, JAMES A.
T1 - Vertebrate Cells Express Protozoan Antigen After Hybridization.
JO - Science
JF - Science
Y1 - 1980/04/11/
VL - 208
IS - 4440
M3 - Article
SP - 194
EP - 196
SN - 00368075
AB - Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtainedfrom the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159105; J. CRANE, MARK ST. 1; DVORAK, JAMES A. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/11/1980, Vol. 208 Issue 4440, p194; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SITARAM, N.
AU - NURNBERGER JR., JOHN I.
AU - GERSHON, ELLIOT S.
AU - GILLIN, J. CHRISTIAN
T1 - Faster Cholinergic REM Sleep Induction in Euthymic Patients with Primary Affective Illness.
JO - Science
JF - Science
Y1 - 1980/04/11/
VL - 208
IS - 4440
M3 - Article
SP - 200
EP - 202
SN - 00368075
AB - Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159108; SITARAM, N. 1; NURNBERGER JR., JOHN I. 1; GERSHON, ELLIOT S. 1; GILLIN, J. CHRISTIAN 2; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Biological Psychiatry Branch, National Institute of Mental Health and Laboratory of Clinical Psychopharmacology, St. Elizabeth's Hospital, Washington, D.C. 20032; Issue Info: 4/11/1980, Vol. 208 Issue 4440, p200; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lin, Thomas T.-S.
AU - Li, Steven S.-L.
T1 - Purification and Physicochemical Properties of Ricins and Agglutinins from Ricinus communis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/04/15/
VL - 105
IS - 3
M3 - Article
SP - 453
EP - 459
PB - Wiley-Blackwell
SN - 00142956
AB - Two toxin ricins and two agglutinins have been purified from the seeds of Ricinus communis by an improved procedure based on ion-exchange chromatography and gel filtration. One of the two purified ricins binds to Sepharose 4B while the other does not. The physicochemical properties of the four Ricinus lectins are presented and the possible relationships of these Ricinus lectins to those previously described are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RICIN
KW - AGGLUTININS
KW - CASTOR oil plant
KW - ION exchange chromatography
KW - GEL permeation chromatography
KW - SEPHAROSE
KW - LECTINS
KW - BLOOD cells
N1 - Accession Number: 13486614; Lin, Thomas T.-S. 1 Li, Steven S.-L. 1; Affiliation: 1: Department of Microbiology, Mount Sinai School of Medicine, New York and National Institute of Environmental Health Sciencs, National Institutes of Health, Research Triangle Park; Source Info: 4/15/80, Vol. 105 Issue 3, p453; Subject Term: RICIN; Subject Term: AGGLUTININS; Subject Term: CASTOR oil plant; Subject Term: ION exchange chromatography; Subject Term: GEL permeation chromatography; Subject Term: SEPHAROSE; Subject Term: LECTINS; Subject Term: BLOOD cells; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gori, Gio Batta
T1 - The Regulation of Carcinogenic Hazards.
JO - Science
JF - Science
Y1 - 1980/04/18/
VL - 208
IS - 4441
M3 - Article
SP - 256
EP - 261
SN - 00368075
N1 - Accession Number: 85159116; Gori, Gio Batta 1; Affiliations: 1: Deputy Director, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 4/18/1980, Vol. 208 Issue 4441, p256; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FINK, DAVID J.
AU - GAINER, HAROLD
T1 - Retrograde Axonal Transport of Endogenous Proteins in Sciatic Nerve Demonstrated by Covalent Labeling in vivo.
JO - Science
JF - Science
Y1 - 1980/04/18/
VL - 208
IS - 4441
M3 - Article
SP - 303
EP - 305
SN - 00368075
AB - Extracellularly applied N-succinimidyl [2,3-3H]propionate was used in vivo to covalently label intra-axonal proteins in the rat sciatic nerve. This technique permitted a unique view of axonal transport of proteins independent of biosynthesis. The proteins detected in slow anterograde transport (I to 2 millimeters per day) correspond to cytoskeletal proteins described in previous reports. The slowly retrogradely transported component (3 to 6 millimeters per day) was composed primarily of a single protein with a molecular weight of 68,000. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159142; FINK, DAVID J. 1; GAINER, HAROLD 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/18/1980, Vol. 208 Issue 4441, p303; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MCLAUGHLIN, CHARLES A.
AU - SCHWARTZMAN, STEVEN M.
AU - HORNER, BONNIE L.
AU - JONES, GORDAN H.
AU - MOFFATT, JOHN G.
AU - NESTOR JR., JOHN J.
AU - TEGG, DEREK
T1 - Regression of Tumors in Guinea Pigs After Treatment with Synthetic Muramyl Dipeptides and Trehalose Dimycolate.
JO - Science
JF - Science
Y1 - 1980/04/25/
VL - 208
IS - 4442
M3 - Article
SP - 415
EP - 416
SN - 00368075
AB - A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guérin in cancer immunotherapy in humans and animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159185; MCLAUGHLIN, CHARLES A. 1; SCHWARTZMAN, STEVEN M. 1; HORNER, BONNIE L. 2; JONES, GORDAN H. 2; MOFFATT, JOHN G. 2; NESTOR JR., JOHN J. 2; TEGG, DEREK 2; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 2: Syntex Research, Palo Alto, California 94304; Issue Info: 4/25/1980, Vol. 208 Issue 4442, p415; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Broder, Samuel
AU - Muul, Linda
AU - Marshall, Sandra
AU - Waldmann, Thomas A.
T1 - Neoplasms of Immunoregulatory T Cells in Clinical Investigation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/05//
VL - 74
IS - 5
M3 - Article
SP - 267
EP - 271
SN - 0022202X
AB - Normal T cells play a critical role in the regulation of humoral immune responses by acting as potentiators (helper cells) or inhibitors (suppressor cells) of the process by which B cells differentiate into immunoglobulin-secreting plasma cells. Certain diseases in which malignant T cells appear to retain an immunoregulatory function are characterized by a propensity of a lymphomatous T-cell population to infiltrate skin. Some cutaneous T-cell lymphoinas, as well as some T-cell neoplasms without derinatologic involvement, provide a homogeneous supply of T lymphocytes which act as immunoregulators. The availability of neoplastic T cells with immunoregulatory properties could accelerate the serologic and biochemical analysis of the cellular control of normal immunity in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - TUMORS
KW - IMMUNE response -- Regulation
KW - SUPPRESSOR cells
KW - CONNECTIVE tissue cells
KW - LYMPHOCYTES
N1 - Accession Number: 12543356; Broder, Samuel 1 Muul, Linda 1 Marshall, Sandra 1 Waldmann, Thomas A. 1; Affiliation: 1: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p267; Subject Term: T cells; Subject Term: TUMORS; Subject Term: IMMUNE response -- Regulation; Subject Term: SUPPRESSOR cells; Subject Term: CONNECTIVE tissue cells; Subject Term: LYMPHOCYTES; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543356
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12543356&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shevach, Ethan M.
T1 - The Role of the Major Histocompatibility Complex in the Regulation of Macrophage-T Lymphocyte Interaction.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/05//
VL - 74
IS - 5
M3 - Article
SP - 289
EP - 291
SN - 0022202X
AB - The proliferative response of guinea pig T lymphocytes which have been primed in vivo can only be induced by antigen-pulsed syngeneic macrophages. The development of techniques to prime T lymphocytes in vitro has allowed us to demonstrate that the genetic restriction on the interaction of the macrophage and T lymphocyte is regulated by the Ia antigens of the macrophage used during the initial sensitization step. Following removal of alloreactive cells, T cells can be sensitized to antigen-treated allogeneic macrophages. It thus appears likely that T cells do not recognize antigen per se, but can only be sensitized to antigen-modified membrane components or to complexes of antigen combined with certain membrane molecules. We postulate that the Ia antigens themselves are the products of the immune response genes and function in both macrophages and B lymphocytes as antigen recognition structures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTOCOMPATIBILITY
KW - MACROPHAGES
KW - T cells
KW - LYMPHOCYTES
KW - CELL interaction (Biology)
KW - TRANSPLANTATION immunology
N1 - Accession Number: 12543471; Shevach, Ethan M. 1; Affiliation: 1: Laboratory of immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p289; Subject Term: HISTOCOMPATIBILITY; Subject Term: MACROPHAGES; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: CELL interaction (Biology); Subject Term: TRANSPLANTATION immunology; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543471
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12543471&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamaki, Kunihiko
AU - Stingl, Georg
AU - Katz, Stephen I.
T1 - The Origin of Langerhans Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/05//
VL - 74
IS - 5
M3 - Article
SP - 309
EP - 311
SN - 0022202X
AB - Langerhans cells constitute a morphologically well-characterized subpopulation (3-8%) of mammalian epidermal cells and, in contrast to the bulk of epidermal cells, bear Fc-IgG and C3 receptors, express immune response associated (Ia) antigens, and function as antigen presenting cells and allogeneic stimulatory cells to primed T lymphocytes. The purpose of this study was to define the ontogeny of Langerhans cells which has been a subject of considerable debate since their discovery in 1868. We have demonstrated that, after 3 weeks, most of the Langerhans cells in parental skin which had been transplanted onto F1 hybrids are of recipient origin whereas keratinocytes remain of donor origin, which indicates that the LC are derived from a mobile pool of cells. Furthermore, in studies of skin from radiation-induced bone marrow chimeric animals we have found that, depending upon the strain combination, up to 80% of the epidermal Langerhans cells are derived from the bone marrow of the donor animals. These studies indicate that epidermal Langerhans cells are derived from and are continuously replenished by a mobile pool of precursor cells which for the most part originate in bone marrow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - EPIDERMIS
KW - CELL receptors
KW - IMMUNE response
KW - T cells
KW - LYMPHOCYTES
N1 - Accession Number: 12543533; Tamaki, Kunihiko 1 Stingl, Georg 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p309; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: LYMPHOCYTES; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543533
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12543533&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stingl, Georg
AU - Katz, Stephen I.
AU - Green, Ira
AU - Shevach, Ethan M.
T1 - The Functional Role of Langerhans Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/05//
VL - 74
IS - 5
M3 - Article
SP - 315
EP - 318
SN - 0022202X
AB - Langerhans cells represent a subpopulation of mammalian epidermal cells. The recent findings that these cells are the only epidermal cells which express Fc-IgG receptors, C3 receptors and La antigens support the early suggestion that they are related to cells from the monocyte-macrophage-histiocyte series. In this report, evidence is presented that epidermal Langerhans cell can replace Ia-bearing macrophages in their capacity to induce antigen-specific and allogeneic T cell activation. The possible clinical implications of these findings are discussed with regard to the role of Langerhans cells as sensitizing factors in contact hypersensitivity and skin graft rejection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - CONNECTIVE tissue cells
KW - EPIDERMIS
KW - CELL receptors
KW - ANTIGEN presenting cells
KW - T cells
N1 - Accession Number: 12543548; Stingl, Georg 1 Katz, Stephen I. 2 Green, Ira 2 Shevach, Ethan M. 2; Affiliation: 1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 2: Dermatology Branch, National Cancer Institute and Lab. of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p315; Subject Term: LANGERHANS cells; Subject Term: CONNECTIVE tissue cells; Subject Term: EPIDERMIS; Subject Term: CELL receptors; Subject Term: ANTIGEN presenting cells; Subject Term: T cells; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543548
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12543548&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawley, Thomas J.
T1 - Immune Complexes and Reticuloendothelial System Function in Human Disease.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/05//
VL - 74
IS - 5
M3 - Article
SP - 339
EP - 343
SN - 0022202X
AB - The interrelation between the presence of circulating antigen-antibody complexes and the functional status of reticuloendothelial system Fc-receptors was studied in patients with systemic lupus erythematosus and Sjogren's syndrome. Both groups of patients had a high prevalence of circulating immune complexes as detected by the 125I-Clq binding assay and the Raji cell radioimmune assay. A number of patients with both diseases were found to have abnormal reticuloendothelial system Fc-receptor function, as measured by the clearance of IgG-sensitized, 51Cr-labeled autologous erythrocytes. In patients with systemic lupus erythematosus there was a high correlation between the presence and levels of immune complexes and abnormal clearance rates. In Sjogren's syndrome on the other hand there was no correlation between the presence or levels of immune complexes and clearance rates. In this disease patients with normal rates of clearance tended to have disease limited to exocrine glands, while patients with abnormal clearance had evidence of more widespread tissue damage. These findings are consistent with the hypothesis that defective reticuloendothelial system function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETICULO-endothelial system
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - CELL receptors
KW - LUPUS erythematosus
KW - SJOGREN'S syndrome
N1 - Accession Number: 12543598; Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May80, Vol. 74 Issue 5, p339; Subject Term: RETICULO-endothelial system; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: CELL receptors; Subject Term: LUPUS erythematosus; Subject Term: SJOGREN'S syndrome; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543598
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2011-08329-010
AN - 2011-08329-010
AU - Savard, Robert J.
AU - Rey, Alix C.
AU - Post, Robert M.
T1 - Halstead-Reitan Category Test in bipolar and unipolar affective disorders: Relationship to age and phase of illness.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/05//
VL - 168
IS - 5
SP - 297
EP - 304
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Savard, Robert J., Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Building 10, Room 3S239, Bethesda, MD, US, 20205
N1 - Accession Number: 2011-08329-010. PMID: 7365494 Partial author list: First Author & Affiliation: Savard, Robert J.; Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Age Differences; Disease Course; Errors; Halstead Reitan Neuropsychological Battery. Minor Descriptor: Bipolar Disorder; Major Depression. Classification: Clinical Psychological Testing (2224); Affective Disorders (3211). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Halstead-Reitan Category Test. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 1980. Copyright Statement: The Williams & Wilkins Co. 1980.
AB - Unipolar and bipolar affectively disturbed patients were administered the Halstead-Reitan category test when in an unmedicated acutely depressed phase and during recovery. Controls consisted of normal volunteers and spouses. Spouse controls were tested at intervals similar to those of the patients and were utilized to control for age, sex, education, and socioeconomic status. Results showed that depressives in the acute depressed state made significantly more errors than did controls. Older bipolar patients made significantly more errors than younger bipolar or younger unipolar patients. In the recovered state the order remained the same. In spite of a decrease in error scores the older bipolar group remained in the abnormal range, whereas the younger groups scored in the normal range with few exceptions. These data suggest that impaired cognitive functioning may be a factor in the disability associated with the major affective disorders in addition to the distorted affective component usually emphasized. Furthermore, in the case of older bipolar patients, the deficit is more severe and may persist beyond the disappearance of affective signs, suggesting that factors associated with age may play an important role in conjunction with other factors associated with bipolar illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Halstead Reitan Category Test
KW - bipolar disorder
KW - major depression
KW - illness phase
KW - errors
KW - age differences
KW - 1980
KW - Affective Disorders
KW - Age Differences
KW - Disease Course
KW - Errors
KW - Halstead Reitan Neuropsychological Battery
KW - Bipolar Disorder
KW - Major Depression
KW - 1980
DO - 10.1097/00005053-198005000-00010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08329-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-08329-011
AN - 2011-08329-011
AU - Donnelly, Edward F.
AU - Weinberger, Daniel R.
AU - Waldman, Ivan N.
AU - Wyatt, Richard Jed
T1 - Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/05//
VL - 168
IS - 5
SP - 305
EP - 308
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Donnelly, Edward F., National Institute of Mental Health, Saint Elizabeths Hospital, William A. White Division, Washington, DC, US, 20032
N1 - Accession Number: 2011-08329-011. PMID: 7365495 Partial author list: First Author & Affiliation: Donnelly, Edward F.; National Institute of Mental Health, Saint Elizabeths Hospital, William A. White Division, Washington, DC, US. Release Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Brain Disorders; Cognitive Impairment; Morphology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Halstead-Reitan Test Battery; Wechsler Adult Intelligence Scale. Methodology: Brain Imaging; Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: May, 1980. Copyright Statement: The Williams & Wilkins Co. 1980.
AB - The Halstead-Reitan Battery (HRB), including the Wechsler Adult Intelligence Scale, was administered to 15 young chronic schizophrenic patients in an attempt to identify blindly those patients with evidence of morphological brain abnormalities on prior computed tomography (CT). The CT scan status of 12 of 15 (80 per cent) patients was correctly identified solely on the basis of neuropsychological testing. These results supported our hypothesis that impairment on the HRB in chronic schizophrenic patients was associated with morphological abnormalities on the CT scan, and that the positive and negative CT scans of these patients could be predicted accurately. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognitive impairment
KW - morphological brain abnormalities
KW - chronic schizophrenia
KW - 1980
KW - Brain
KW - Brain Disorders
KW - Cognitive Impairment
KW - Morphology
KW - Schizophrenia
KW - 1980
DO - 10.1097/00005053-198005000-00011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-08329-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FLIER, JEFFREY
AU - EDWARDS, MICHAEL W.
AU - DALY, JOHN W.
AU - MYERS, CHARLES W.
T1 - Widespread Occurrence in Frogs and Toads of Skin Compounds Interacting with the Ouabain Site of Na+,K+-ATPase.
JO - Science
JF - Science
Y1 - 1980/05/02/
VL - 208
IS - 4443
M3 - Article
SP - 503
EP - 505
SN - 00368075
AB - Amphibians of the family Bufonidae contain high levels of skin compounds that both inhibit Na+- and K+-dependent adenosinetriphosphatase and antagonize the binding of ouabain to the enzyme. In species of Bufo and Atelopus, these compounds are relatively nonpolar bufodienolides, whereas Dendrophryniscus and Melanophryniscus contain more polar compounds of unknown structure. Skin extracts from 30 of 48 species of frogs representing an additional eight families contained relatively low levels of compounds that inhibit binding of ouabain to Na+,K+-adenosinetriphosphatase. The widespread occurrence of low levels of inhibitory compounds is consonant with the role for these compounds as physiological regulators of Na+,K+-adenosinetriphosphatase in amphibian skin; high levels in the Bufonidae probably also serve as a defense against some predators. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159224; FLIER, JEFFREY 1; EDWARDS, MICHAEL W. 2; DALY, JOHN W. 2; MYERS, CHARLES W. 3; Affiliations: 1: Beth Israel Hospital, Boston, Massachusetts 02215; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Herpetology, American Museum of Natural History, New York 10024; Issue Info: 5/ 2/1980, Vol. 208 Issue 4443, p503; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HUBERT, HELEN B.
AU - FABSITZ, RICHARD R.
AU - FEINLEIB, MANNING
AU - BROWN, KENNETH S.
T1 - Olfactory Sensitivity in Humans: Genetic Versus Environmental Control.
JO - Science
JF - Science
Y1 - 1980/05/09/
VL - 208
IS - 4444
M3 - Article
SP - 607
EP - 609
SN - 00368075
AB - Olfactory sensitivity to acetic acid, isobutyric acid, and 2-sec-butyl-cyclohexanone was tested in 97 adult male twin pairs to determine the extent to which variation in odor perception was genetically determined. Analysis of the data revealed no evidence for heritability of olfactory sensitivity. However, factors significantly associated with odor perception included cigar, pipe, and cigarette smoking; body fatness; alcohol consumption; and diabetes mellitus [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159262; HUBERT, HELEN B. 1; FABSITZ, RICHARD R. 1; FEINLEIB, MANNING 1; BROWN, KENNETH S. 2; Affiliations: 1: Epidemiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda 20205; Issue Info: 5/ 9/1980, Vol. 208 Issue 4444, p607; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROBIE-SUH, K.
AU - ROBINSON, R.
AU - GELBOIN, H. V.
AU - GUENGERICH, F. PETER
T1 - Aryl Hydrocarbon Hydroxylase Is Inhibited by Antibody to Rat Liver Cytochrome P-450.
JO - Science
JF - Science
Y1 - 1980/05/30/
VL - 208
IS - 4447
M3 - Article
SP - 1031
EP - 1033
SN - 00368075
AB - Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159379; ROBIE-SUH, K. 1; ROBINSON, R. 1; GELBOIN, H. V. 1; GUENGERICH, F. PETER 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Biochemistry and Center in Environmental Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1031; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - MACDONALD, JOHN F.
T1 - Picrotoxin Convulsions Involve Synaptic and Nonsynaptic Mechanisms on Cultured Mouse Spinal Neurons.
JO - Science
JF - Science
Y1 - 1980/05/30/
VL - 208
IS - 4447
M3 - Article
SP - 1054
EP - 1056
SN - 00368075
AB - The cellular mechanisms underlying picrotoxin-induced convulsive activity were studied by using mouse spinal neurons growing in tissue culture. Picrotoxin-induced convulsive activity in most but not all of the cells studied. The activity could be inverted by polarizing to positive potentials and eliminated either by decreasing the ratio of calcium to magnesium or by applying tetrodotoxin. When applied locally to individual cells, picrotoxin lowered spike threshold and induced spontaneous firing in some but not all cells tested. The results suggest that picrotoxin-induced convulsive activity involves rapidly summating synaptic activity which may be evoked by high-frequency repetitive firing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85159390; BARKER, JEFFERY L. 1; MACDONALD, JOHN F. 2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: Helen Scott Playfair Neuroscience Unit, University of Toronto, Toronto Western Hospital, Toronto, Canada; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1054; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLOWDEN, MARC J.
AU - BEACH, RAYMOND
T1 - Large Doses of Ecdysterone May Inhibit Mosquito Behavior Nonspecifically.
JO - Science
JF - Science
Y1 - 1980/05/30/
VL - 208
IS - 4447
M3 - Article
SP - 1062
EP - 1063
SN - 00368075
N1 - Accession Number: 85159394; KLOWDEN, MARC J. 1; BEACH, RAYMOND 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 5/30/1980, Vol. 208 Issue 4447, p1062; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hall, R. P.
AU - Lawley, T. J.
AU - Heck, J. A.
AU - Katz, S. I.
T1 - IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schonlein purpura, systemic lupus erythematosus and other diseases.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/06//
VL - 40
IS - 3
M3 - Article
SP - 431
EP - 437
PB - Wiley-Blackwell
SN - 00099104
AB - The sera of patients with dermatitis herpetifomis. Henoch-Schönlein purpura and systemic lupus erythematosus were examined for IgA-containing immune complexes using a newly described radioimmunoassay. The IgG Raji cell radioimmunoassay and the 125I-Clq binding assay were also used to detect IgG-and IgM-containing soluble immune complexes, IgA-containing immune complexes were found in the sera of twelve of forty-nine (24%) patients with dermatitis herpetiformis, four of six (67%) patients with Henoch-Schönlein purpura, and seven of ten (70%) patients with systemic lupus erythematosus. IgG-or IgM-containing immune complexes were also found in six of forty-seven patients with dermatitis herpetifomis, in one of six patients with Henoch-Schönlein purpura, and in nine of ten patients with systemic lupus erythematosus, by either the 125I-Clq binding assay or the IgG Raji cell assay. The finding of soluble IgA immune complexes in a high percentage of patients with systemic lupus erythematosus and Henoch-Schönlein purpura suggests that they may play an important role in the pathogenesis of these diseases. In contrast, their low prevalence in patients with dermatitis herpetifomis suggests that IgA-containing immune complexes may not play a major role in the pathogenesis of dermatitis herpetiformis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - SYSTEMIC lupus erythematosus
KW - IMMUNOGLOBULINS
KW - IMMUNOGLOBULIN G
KW - BLOOD plasma
KW - VASCULAR diseases
N1 - Accession Number: 18001181; Hall, R. P. 1 Lawley, T. J. 1 Heck, J. A. 1 Katz, S. I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA.; Source Info: Jun1980, Vol. 40 Issue 3, p431; Subject Term: SKIN diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOGLOBULIN G; Subject Term: BLOOD plasma; Subject Term: VASCULAR diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Noronha-Blob, Lalita
AU - Huang, Shih-Wen
T1 - An in vitro assay for uni-directional migration inhibition employing 5lCr-labelled macrophages.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/06//
VL - 40
IS - 3
M3 - Article
SP - 627
EP - 632
PB - Wiley-Blackwell
SN - 00099104
AB - An improved in vitro technique to assay for migration inhibitory factor is presented. The method employs chromium-51-radiolabelled guinea-pig macrophages and offers significant advantages including (1) elimination of observer to observer variation and tedious measurements resulting in an objective and technically simple assay, (2) the requirement for small numbers of immune lymphocytes, (3) good sensitivity and reproducibility between successive assays performed on different days. and (4) a means of obtaining relative estimates of the 'strength' (concentration) of the factor so that comparisons with healthy individuals can be made. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - CHROMIUM group
KW - LEUCOCYTES
KW - SWINE
KW - MACROPHAGES
KW - LYMPHOCYTES
N1 - Accession Number: 18002097; Noronha-Blob, Lalita 1 Huang, Shih-Wen 2; Affiliation: 1: Gerontology Research Center, National Institute of Aging, NIH, Baltimore City Hospitals, University of Maryland School of Medicine, Baltimore, Maryland, USA. 2: Division of Pediatric Allergy and Immunology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Source Info: Jun1980, Vol. 40 Issue 3, p627; Subject Term: KILLER cells; Subject Term: CHROMIUM group; Subject Term: LEUCOCYTES; Subject Term: SWINE; Subject Term: MACROPHAGES; Subject Term: LYMPHOCYTES; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olson, Lucy
AU - Liebow, Elliot
AU - Mannino, Fortune V.
AU - Shore, Milton F.
T1 - Runaway Children Twelve Years Later.
JO - Journal of Family Issues
JF - Journal of Family Issues
Y1 - 1980/06//
VL - 1
IS - 2
M3 - Article
SP - 165
EP - 188
SN - 0192513X
AB - THIS is a 12-year follow-up pilot study of 14 youths who ran away from home in the mid-1960s. The study is based on 44 intensive interviews with the former runaways, their nonrunaway siblings, their parents, and other relatives. Four major questions were addressed. Marked differences in outcomes were found (a) between runaways and their siblings; (b) between runaway repeaters and nonrepeaters, and (c) between runaways from working-class backgrounds and those from middle-class backgrounds. In general, whatever their other statuses, children who ran away more than once showed increasing personal and social dysfunction as young adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RUNAWAY children
KW - SOCIAL background
KW - HOMELESS children
KW - MISSING persons
KW - PARENT & child
KW - FAMILIES
N1 - Accession Number: 13543708; Olson, Lucy 1; Liebow, Elliot 2; Mannino, Fortune V. 3; Shore, Milton F. 4; Source Information: Jun1980, Vol. 1 Issue 2, p165; Subject: RUNAWAY children; Subject: SOCIAL background; Subject: HOMELESS children; Subject: MISSING persons; Subject: PARENT & child; Subject: FAMILIES; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Neifeld, James P.
AU - Lippman, Marc E.
T1 - Steroid Hormone Receptors and Melanoma.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/06//
VL - 74
IS - 6
M3 - Article
SP - 379
EP - 381
SN - 0022202X
AB - This article focuses on the relationship between steroid hormone receptors and melanomas. Different classes of steroid hormones are thought to exert their specific effects on cells through similar mechanisms. Cell membranes are freely permeable to steroid hormones. Once inside the cell the steroid binds to an intracellular protein. The receptor-steroid complex then undergoes a temperature dependent activation step, which permits nuclear translocation and presumed binding to specific nuclear sites. Transcription of specific DNA segments ensues with apparent regulation at least at the level of the primary mRNA transcript.
KW - STEROID receptors
KW - MELANOMA
KW - CELL membranes
KW - PROTEIN binding
KW - DNA
KW - MESSENGER RNA
N1 - Accession Number: 12544454; Neifeld, James P. 1 Lippman, Marc E. 2; Affiliation: 1: Division of Surgical Oncology and MCV- VCU Cancer Center, Medical College of Virginia, Richmond, Virginia. 2: Medical Breast Cancer Service, Medicine Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jun80, Vol. 74 Issue 6, p379; Subject Term: STEROID receptors; Subject Term: MELANOMA; Subject Term: CELL membranes; Subject Term: PROTEIN binding; Subject Term: DNA; Subject Term: MESSENGER RNA; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12544454
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-20770-011
AN - 2004-20770-011
AU - Patrick, Clifford H.
T1 - Health and Migration of the Elderly.
JF - Research on Aging
JO - Research on Aging
JA - Res Aging
Y1 - 1980/06//
VL - 2
IS - 2
SP - 233
EP - 241
CY - US
PB - Sage Publications
SN - 0164-0275
SN - 1552-7573
N1 - Accession Number: 2004-20770-011. Partial author list: First Author & Affiliation: Patrick, Clifford H.; Epidemiology, Demography, and Biometry Program, National Institute on Aging, NIH, US. Release Date: 20050110. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Health; Human Migration; Long Term Care. Minor Descriptor: Nursing Homes; Retirement. Classification: Gerontology (2860); Social Structure & Organization (2910). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). References Available: Y. Page Count: 9. Issue Publication Date: Jun, 1980.
AB - The degree to which migration decisions of the elderly are influenced by health status is largely unknown. Two seemingly contradictory influences of health on migration are possible within the older cohort. First, those elderly in good health would appear more likely to make discretionary moves, such as to retirement homes in the Sunbelt, than elderly who are in poor health. Alternatively, those elderly in declining health, such as stroke victims, seem more likely to be involved in a move to a long-term care facility. While both types of migration related to health occur, the size of the first relative to the second and the distance of the moves of each type need to be determined. Both types of health-related migration have policy implications which are briefly addressed in this article. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health status
KW - migration
KW - elderly people
KW - retirement homes
KW - long-term care
KW - 1980
KW - Aging
KW - Health
KW - Human Migration
KW - Long Term Care
KW - Nursing Homes
KW - Retirement
KW - 1980
DO - 10.1177/016402758022011
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Goldman, Robert C.
AU - Leive, Loretta
T1 - Heterogeneity of Antigenic-Side-Chain Length in Lipopolysaccharide from Escherichia coli 0111 and Salmonella typhimurium LT2.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/06/12/
VL - 107
IS - 1
M3 - Article
SP - 145
EP - 153
PB - Wiley-Blackwell
SN - 00142956
AB - Lipopolysaccharide from Escherichia coli 0111, its galE derivative when grown in galactose, E. coli 086, and Salmonella typhimurium LT2 all contain antigenic side chains and separate into more than 40 components by electrophoresis in gradients of polyacrylamide containing sodium dodecylsulfate. These components from E. coli 0111 are not interconvertible and show a heterogeneous size distribution when fractionated with Sephadex G-200. Isoelectric focusing of this mixture in pH 3.5–10 ampholines reveals a single component, ruling out extensive charge heterogeneity. The relative antigenic side chain lengths for the components, estimated using ratios of galactose in antigenic side chain to phosphate in the lipid-A—core oligosaccharide region, show that the size heterogeneity is due to differences in the number of antigenic side chain units per molecule and ranges from none to over 40. Preference for molecules of specific chain lengths, especially short ones, was observed. In contrast, the gale mutant grown without galactose does not synthesize antigenic side chains, and more than 90% of its lipopolysaccharide migrates as a single band at a position corresponding to the lowest-molecular-weight component from the above preparations. Lipopolysaccharide from E. coli PL2, a K12 strain lacking antigenic side chain, separates into two low-molecular-weight components on electrophoresis. These results confirm that the heterogeneity which we observe in lipopolysaccharide containing antigenic side chains, is due to the side chain rather than the lipid-A—core oligosaccharide region. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - ESCHERICHIA coli
KW - GALACTOSE
KW - SALMONELLA typhimurium
KW - POLYACRYLAMIDE
KW - GRAM-negative bacteria
N1 - Accession Number: 13491740; Goldman, Robert C. 1 Leive, Loretta 1; Affiliation: 1: Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda; Source Info: 6/12/80, Vol. 107 Issue 1, p145; Subject Term: ENDOTOXINS; Subject Term: ESCHERICHIA coli; Subject Term: GALACTOSE; Subject Term: SALMONELLA typhimurium; Subject Term: POLYACRYLAMIDE; Subject Term: GRAM-negative bacteria; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GOOSEY, JOHN D.
AU - ZIGLER JR., J. SAMUEL
AU - KINOSHITA, JIN H.
T1 - Cross-Linking of Lens Crystallins in a Photodynamic System: A Process Mediated by Singlet Oxygen.
JO - Science
JF - Science
Y1 - 1980/06/13/
VL - 208
IS - 4449
M3 - Article
SP - 1278
EP - 1280
SN - 00368075
AB - In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a bluefluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437680; GOOSEY, JOHN D. 1; ZIGLER JR., J. SAMUEL 1; KINOSHITA, JIN H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 6/13/1980, Vol. 208 Issue 4449, p1278; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOLDENBERG, DAVID M.
AU - KIM, EDMUND E.
AU - DELAND, FRANK H.
AU - VAN NAGELL Jr., JOHN R.
AU - JAVADPOUR, NASSER
T1 - Clinical Radioimmunodetection of Cancer with Radioactive Antibodies to Human Chorionic Gonadotropin.
JO - Science
JF - Science
Y1 - 1980/06/13/
VL - 208
IS - 4449
M3 - Article
SP - 1284
EP - 1286
SN - 00368075
AB - Injection of iodine-131 -labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumorlnontumor ratio of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437683; GOLDENBERG, DAVID M. 1,2; KIM, EDMUND E. 3,4; DELAND, FRANK H. 3,4; VAN NAGELL Jr., JOHN R. 5; JAVADPOUR, NASSER 6; Affiliations: 1: Division of Experimental Pathology, Department of Pathology, University of Kentucky, Lexington 40536; 2: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Division of Nuclear Medicine, Department of Radiation Medicine, University of Kentucky; 4: Veterans Administration Medical Center, Lexington, Kentucky 40536; 5: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Medical Center; 6: Surgery Branch, National Cancer Institute, National Institutes of Health; Issue Info: 6/13/1980, Vol. 208 Issue 4449, p1284; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DALY, JOHN W.
AU - MYERS, CHARLES W.
AU - WARNICK, JORDAN E.
AU - ALBUQUERQUE, EDSON X.
T1 - Levels-of Batrachotoxin and Lack of Sensitivity to Its Action in Poison-Dart Frogs (Phyllobates).
JO - Science
JF - Science
Y1 - 1980/06/20/
VL - 208
IS - 4450
M3 - Article
SP - 1383
EP - 1385
SN - 00368075
N1 - Accession Number: 85196138; DALY, JOHN W. 1; MYERS, CHARLES W. 2; WARNICK, JORDAN E. 3; ALBUQUERQUE, EDSON X. 3; Affiliations: 1: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Herpetology, American Museum of Natural History, New York 10024; 3: Department of Pharmacology and Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201; Issue Info: 6/20/1980, Vol. 208 Issue 4450, p1383; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gollapudi, Sastry V. S.
AU - Kern, Milton
T1 - Lipid A Induces cells, Uniquely Present in Bone Marrow, to Secrete Proteins other than Immunoglobulins.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/07//7/1/80
VL - 108
IS - 1
M3 - Article
SP - 233
EP - 237
PB - Wiley-Blackwell
SN - 00142956
AB - The lipid-A moiety of lipopolysaccharide induced freshly isolated bone marrow cells incubated with radioactive leucine to exhibit enhanced release of proteins other than immunoglobulins. Such stimulation by lipopolysaccharide was essentially not observed with cell suspensions from spleen, thymus, appendix, peritoneal exudate, whole blood, lymph node, liver, testis, buffy coat of blood and reticulocyte-enriched blood. The extracellular appearance of proteins was shown to be due to secretion by excluding other alternatives. Thus, the rate of cell death and/or leakage of cellular contents, as well as the rate of shedding of surface membrane protein, was unaffected measurably by lipopolysaccharide. Secretion of non-immunoglobulin proteins was selective as judged by the finding that the rate of immunoglobulin released by bone marrow cells during the usual four-hour pulse-label period was not stimulated by lipopolysaccharide. Enhancement of mitogenesis and enhancement of secretion of non-immunoglobulin protein by lipopolysaccharide appeared to occur at independent sites or even in different ceils because splenocytes which readily exhibited mitogenic response to lipopolysaccharide essentially did not exhibit stimulation of secretion of non-immunoglobulin protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE marrow cells
KW - SECRETION
KW - PROTEINS
KW - IMMUNOGLOBULINS
KW - LIPIDS
KW - LEUCINE
KW - CELL suspensions
N1 - Accession Number: 13606669; Gollapudi, Sastry V. S. 1 Kern, Milton 1; Affiliation: 1: National Institutes of Arthritis, Metabolism and Digestive Diseases National Institutes of Health, Bethesda; Source Info: 7/1/80, Vol. 108 Issue 1, p233; Subject Term: BONE marrow cells; Subject Term: SECRETION; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULINS; Subject Term: LIPIDS; Subject Term: LEUCINE; Subject Term: CELL suspensions; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamaki, Kunihiko
AU - Katz, Stephen I.
T1 - Ontogeny of Langerhans Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/07//
VL - 75
IS - 1
M3 - Article
SP - 12
EP - 13
SN - 0022202X
AB - Results of transplantation and chimera studies indicate that epidermal Langerhans cells are derived from precursor cells originating in bone marrow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONTOGENY
KW - EMBRYOLOGY
KW - BIOLOGY
KW - LANGERHANS cells
KW - DENDRITIC cells
KW - BONE marrow
N1 - Accession Number: 12521037; Tamaki, Kunihiko 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul80, Vol. 75 Issue 1, p12; Subject Term: ONTOGENY; Subject Term: EMBRYOLOGY; Subject Term: BIOLOGY; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: BONE marrow; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1523-1747.ep12521037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Green, Ira
AU - Stingl, Georg
AU - Shevach, Ethan M.
AU - Katz, Stephen I.
T1 - Antigen Presentation and Allogeneic Stimulation by Langerhans Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/07//
VL - 75
IS - 1
M3 - Article
SP - 44
EP - 45
SN - 0022202X
AB - Isolated Langerhans cells were studied for 2 immunologic functions, the ability to present antigen to sensitized T lymphocytes and the ability to act as stimulator cells for mixed lymphocyte reactions. Langerhans cells can perform both of these functions. This fact, with the previous finding that Langerhans cells possess surface la antigens and Fe and C3 receptors, strongly suggests that Langerhans cells act as epidermal macrophages. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGEN presenting cells
KW - LANGERHANS cells
KW - IMMUNOGLOBULINS
KW - LYMPHOCYTES
KW - CELL physiology
KW - IA antigens
KW - CELL receptors
N1 - Accession Number: 12521102; Green, Ira 1 Stingl, Georg 2 Shevach, Ethan M. 3 Katz, Stephen I. 4; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy, Bethesda, Maryland. 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland. 3: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 4: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul80, Vol. 75 Issue 1, p44; Subject Term: ANTIGEN presenting cells; Subject Term: LANGERHANS cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPHOCYTES; Subject Term: CELL physiology; Subject Term: IA antigens; Subject Term: CELL receptors; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1523-1747.ep12521102
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2011-11212-001
AN - 2011-11212-001
AU - Cowan, Jonathan D.
AU - Kay, David C.
AU - Neidert, Gary L.
AU - Ross, Frances E.
AU - Belmore, Susan M.
T1 - Defeated and Joyless: Potential measures of change in drug abuser characteristics.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1980/07//
VL - 168
IS - 7
SP - 391
EP - 399
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Kay, David C., National Institute on Drug Abuse Addiction Research Center, P. O. Box 12390, Lexington, KY, US, 40583
N1 - Accession Number: 2011-11212-001. PMID: 7400787 Partial author list: First Author & Affiliation: Cowan, Jonathan D.; National Institute on Drug Abuse, Division of Research, Addiction Research Center, US. Release Date: 20110704. Correction Date: 20140915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Emotional States; Questionnaires; Self-Concept; Test Construction. Minor Descriptor: Alcoholism; Opiates; Test Validity. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Lack of Confidence Scale; Unpopularity Scale; Low Energy Scale; Joyless Scale [Appended]; Defeated Scale [Appended]; Profile of Mood States; Present Affect Rating; Maturity Scale; California Personality Inventory; Social Experience Questionnaire DOI: 10.1037/t10619-000; Minnesota Multiphasic Personality Inventory; Addiction Research Center Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 1980.
AB - Defeated and Joyless scales were developed from a questionnaire given to 54 normal, 53 alcoholic, and 28 opiate addict subjects. The Defeated scale differentiates the alcoholics and addicts from normals but not from each other, whereas the Joyless scale differentiates addicts from both alcoholics and normals. When shown to 48 college students, a film about poverty increased the Joyless score, as well as other measures, but had little effect on the Defeated score. These scales appear to distinguish between self-concept (Defeated) and mood (Joyless) components of hypophoria, an affective disorder hypothesized to be associated with drug abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Defeated scale
KW - Joyless scale
KW - test development
KW - alcoholism
KW - opiate addiction
KW - discriminative validity
KW - hypophoria
KW - drug abuse
KW - 1980
KW - Addiction
KW - Emotional States
KW - Questionnaires
KW - Self-Concept
KW - Test Construction
KW - Alcoholism
KW - Opiates
KW - Test Validity
KW - 1980
DO - 10.1097/00005053-198007000-00001
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06560-053
AN - 2006-06560-053
AU - Woolf, Bertie H.
T1 - And a Time for Dying.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1980/07//
VL - 25
IS - 7
SP - 574
EP - 575
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06560-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Woolf, Bertie H.; Division of Research Grants, National Institutes of Health (NIH), Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Death and Dying; Mental Disorders; Psychiatric Patients. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Wendkos, Martin H. Sudden Death and Psychiatric Illness=New York: SP Medical & Scientific Books, 1979. Pp. 349. $20.00; 1979. Page Count: 2. Issue Publication Date: Jul, 1980.
AB - Reviews the book, Sudden Death and Psychiatric Illness by Martin H. Wendkos (1979). This volume presents an overview of nonsuicidal sudden death syndromes, with special reference to unexpected deaths in psychiatric patients. Case histories and clinical and epidemiological studies are examined and reexamined in the search for risk factors. The health professional who deals with psychiatric patients will find this book interesting. The book's message is clear--the whole picture must always be considered, including the patient's current physical and mental status, the possibility of drug interaction or overdose, the effect of depression, and so forth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric patients
KW - sudden death syndromes
KW - mental status
KW - psychiatric illness
KW - 1980
KW - Death and Dying
KW - Mental Disorders
KW - Psychiatric Patients
KW - 1980
U2 - Wendkos, Martin H. (1979); Sudden Death and Psychiatric Illness; New York: SP Medical & Scientific Books, 1979. Pp. 349. $20.00
DO - 10.1037/018189
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - HELD, JOE R.
AU - SEILING, ELEANOR
T1 - Animals in the Lab.
JO - Science
JF - Science
Y1 - 1980/07/11/
VL - 209
IS - 4453
M3 - Article
SP - 214
EP - 214
SN - 00368075
N1 - Accession Number: 85196201; HELD, JOE R. 1; SEILING, ELEANOR 2; Affiliations: 1: Division of Research Services, National Institutes of Health, Bethesda, Maryland, 20205; 2: United Action for Animals, Inc., 205 East 42 Street, New York, 10017; Issue Info: 7/11/1980, Vol. 209 Issue 4453, p214; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAKUNAGA, TAKEO
AU - CROW, JANET D.
T1 - Cell Variants Showing Differential Susceptibility to Ultraviolet Light-Induced Transformation.
JO - Science
JF - Science
Y1 - 1980/07/25/
VL - 209
IS - 4455
M3 - Article
SP - 505
EP - 507
SN - 00368075
AB - Six variant clones isolated from a subclone of BALB13T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196321; KAKUNAGA, TAKEO 1; CROW, JANET D. 1; Affiliations: 1: Cell Genetics Section, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 7/25/1980, Vol. 209 Issue 4455, p505; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MATHERS, DAVID A.
AU - BARKER, JEFFERY L.
T1 - (-)Pentobarbital Opens Ion Channels of Long Duration in Cultured Mouse Spinal Neurons.
JO - Science
JF - Science
Y1 - 1980/07/25/
VL - 209
IS - 4455
M3 - Article
SP - 507
EP - 509
SN - 00368075
AB - Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to γ-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by γ-aminobutyric acid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196322; MATHERS, DAVID A. 1; BARKER, JEFFERY L. 1; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 7/25/1980, Vol. 209 Issue 4455, p507; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Garcia-Palmieri, Mario R.
AU - Sorlie, Paul
AU - Tillotson, Jeanne
AU - Costas, Jr., Raul
AU - Cordero, Edna
AU - Rodriguez, Maresa
T1 - Relationship of dietary intake to subsequent coronary heart disease incidence: The Puerto Rico Heart Health Program.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1980/08//
VL - 33
IS - 8
M3 - Article
SP - 1818
EP - 1827
SN - 00029165
AB - A study of base-line nutrient intakes of 8218 urban and rural Puerto Rican men aged 45 to 64 years was undertaken in relation to subsequent six year coronary heart disease (CHD) incidence. Urban dietary intakes were significantly higher in total fat and lower in carbohydrate, particularly starch. Average cholesterol intakes were 83 mg/day higher in urban than rural men. Urban serum cholesterol values were significantly higher than rural values. -Urban men who developed myocardial infarction or CHD death had significantly lower calorie and carbohydrate intakes, i.e., chiefly those derived from rice and legumes. The same association was found in the rural group but failed to reach statistical significance. A very low intake of alcohol was noted in the 73 rural CHD cases. Dietary sucrose intake showed no relationship to CHD incidence. Multivariate analysis, taking relative weight, hematocrit, blood pressure, serum cholesterol, alcohol intake, cigarette smoking, area, and age into account, demonstrated an independent inverse relation of carbohydrate intake from legumes to CHD incidence. The apparent protective effect of complex carbohydrate merits further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 94366696; Garcia-Palmieri, Mario R. 1; Sorlie, Paul 2; Tillotson, Jeanne 3; Costas, Jr., Raul 4; Cordero, Edna 5; Rodriguez, Maresa 5; Affiliations: 1: Director, Puerto Rico Heart Health Program, and Professor and Head, Department of Medicine, University of Puerto Rico; 2: Statistician, Division of Heart and Vascular Diseases, Biometrics Research Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland; 3: Nutritionist, Clinical Applications and Prevention Program, Division of Heart and Vascular Diseases; National Heart, Lung, and Blood Institute, Bethesda, Maryland; 4: Associate Director, Puerto Rico Heart Health Program and Professor, Departmetn of Medicine, University of Puerto Rico; 5: Dietitian, Puerto Rico Heart Health Program, University of Puerto Rico; Issue Info: Aug1980, Vol. 33 Issue 8, p1818; Number of Pages: 10p; Illustrations: 9 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Blot, William J.
T1 - Changing Patterns of Breast Cancer among American Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/08//
VL - 70
IS - 8
M3 - Article
SP - 832
EP - 835
PB - American Public Health Association
SN - 00900036
AB - Abstract: Although overall mortality from breast cancer has changed little over time in the United States, age-specific rates showed distinctive patterns during 1950-75, with declines among premenopausal women, a rise then fall among perimenopausal women, and level then increasing rates among postmenopausal women. The trends appear related to the changing patterns of childbearing among young adult women over the first two-thirds of this century, The national mortality and birth data presented are consistent with existing analytic evidence of a protective influence upon breast cancer of early first birth, and suggest that the protection may be expressed at all ages above 30. (Am J Public Health 1980: 70:833-836.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - MORTALITY
KW - MENOPAUSE
KW - CHILDBIRTH
KW - WOMEN -- Diseases
KW - CANCER in women
KW - AGE groups
KW - AGE differences
KW - RISK factors
KW - UNITED States
N1 - Accession Number: 4952129; Blot, William J. 1; Affiliation: 1: Head, Analytical Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20205; Source Info: Aug1980, Vol. 70 Issue 8, p832; Subject Term: BREAST cancer; Subject Term: MORTALITY; Subject Term: MENOPAUSE; Subject Term: CHILDBIRTH; Subject Term: WOMEN -- Diseases; Subject Term: CANCER in women; Subject Term: AGE groups; Subject Term: AGE differences; Subject Term: RISK factors; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ida, S.
AU - Hooks, J. J.
AU - Siraganian, R. P.
AU - Notkins, A.L.
T1 - Enhancement of IgE-mediated histamine release from human basophils by immune-specific lymphokines.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/08//
VL - 41
IS - 2
M3 - Article
SP - 380
EP - 387
PB - Wiley-Blackwell
SN - 00099104
AB - Human leucocytes (basophils) release histamine when exposed to ragweed antigen E or anti-IgE. The present study shows that when leucocytes from BCG-positive donors are first incubated with PPD and then challenged with anti-IgE, histamine release is enhanced. In contrast, when leucocytes from BCG-negative donors are incubated with PPD and then challenged with anti-IgE there is no enhancement of histamine release. The enhancement of histamine release was detected within 24 hr after addition of PPD, but was maximal at 48 to 72 hr. Supernatant fluids collected from these leucocyte cultures revealed the presence o f a soluble mediator(s) which, when incubated with leucocytes from BCG-negative donors, enhanced the release of histamine. Examination of the supernatant fluids from BCG-positive leucocyte cultures stimulated with PPD showed a correlation between histamine-release enhancing activity and interferon. Treatment of the culture fluids at pH 2.0 abolished the anti-viral activity, indicating that the interferon was of the type II or 'immune' class. The same treatment only partly abolished the histamine-release enhancing activity. It is concluded that immune-specific stimulation of leucocytes results in the release of soluble mediators that are capable of enhancing IgE-mediated histamine release. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLAMMATION -- Mediators
KW - HISTAMINE
KW - ANTIHISTAMINES
KW - LEUCOCYTES
KW - FLUID mechanics
KW - CYTOKINES
N1 - Accession Number: 15985168; Ida, S. 1 Hooks, J. J. 1 Siraganian, R. P. 2 Notkins, A.L. 1; Affiliation: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA. 2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Aug1980, Vol. 41 Issue 2, p380; Subject Term: INFLAMMATION -- Mediators; Subject Term: HISTAMINE; Subject Term: ANTIHISTAMINES; Subject Term: LEUCOCYTES; Subject Term: FLUID mechanics; Subject Term: CYTOKINES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horowitz, Alice M.
AU - Suomi, John D.
AU - Peterson, John K.
AU - Mathews, Barbara L.
AU - Voglesong, Ronald H.
AU - Lyman, Beverly A.
T1 - Effects of supervised daily dental plaque removal by children after 3 years.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1980/08//
VL - 8
IS - 4
M3 - Article
SP - 171
EP - 176
SN - 03015661
AB - The benefits of a school-based plaque removal program arc presented. Children in grades 5-8 were included in a study which was designed to determine the effect on oral hygiene, gingival inflammation and dental caries of removing dental plaque through supervised daily flossing and toothbrushing in school. A fluoride-free dentifrice was used. Controls did not receive instruction in plaque removal procedures nor did they engage in plaque removal activities at school. For three school years the students in the treatment group practiced daily plaque removal, supervised by trained personnel. All participants were examined initially for plaque (PHP), gingival inflammation (DHC) and dental caries (DMFS). Girls in the treatment group showed a significant reduction (28%) in mean plaque scores and, for girls and boys, the mean changes in gingivitis scores were significantly reduced (40% and 17%, respectively). Adjusted mean incremental DMF surface scores were 13% lower in the treatment group than in the control group. The difference between groups was not statistically significant and was accounted for entirely by the findings in mesial and distal surfaces (26%). This difference approached statistical significance (P= 0.07). [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINGIVITIS
KW - GUM disease
KW - DENTAL caries
KW - ORAL hygiene
KW - DENTAL plaque
KW - DENTISTRY
KW - dental caries
KW - flossing
KW - gingivitis
KW - oral hygiene
KW - plaque removal
KW - toothbrushing.
N1 - Accession Number: 12057589; Horowitz, Alice M. 1 Suomi, John D. 2 Peterson, John K. 3 Mathews, Barbara L. 4 Voglesong, Ronald H. 4 Lyman, Beverly A. 4; Affiliation: 1: National Caries Program, National Institute of Dental Research, National Institutes of Health, U. S. Department of Health, Education and Welfare, Bethesda, Maryland. 2: Dental Affairs Staff Office of Assistant Secretary for Health, PHS U. S. Department of Health, Education and Welfare, Rockville, Maryland. 3: Division of Denial Health, .North Dakota Slate Department of Health, Bismarck, North Dakota. 4: Section of Dental Health, Connecticut Slate Department of Health, Hartford, Connecticut, U.S.A.; Source Info: Aug1980, Vol. 8 Issue 4, p171; Subject Term: GINGIVITIS; Subject Term: GUM disease; Subject Term: DENTAL caries; Subject Term: ORAL hygiene; Subject Term: DENTAL plaque; Subject Term: DENTISTRY; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: flossing; Author-Supplied Keyword: gingivitis; Author-Supplied Keyword: oral hygiene; Author-Supplied Keyword: plaque removal; Author-Supplied Keyword: toothbrushing.; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12057589
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horowitz, Herschel S.
AU - Heifetz, Stanley B.
AU - Meyers, Rhea J.
AU - Driscoll, William S.
AU - Shou-Hua Li, William S.
T1 - A program of self-administered fluorides in a rural school system.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1980/08//
VL - 8
IS - 4
M3 - Article
SP - 177
EP - 183
SN - 03015661
AB - In 1972, a self-administered fluoride program was initiated in Nelson County, VA, a fluoride-deficient area. Children in elementary school (grades K-6) ingest daily a 1-mg fluoride tablet, rinse weekly with 0.2% NaF solution and receive fluoride dentifrice for home use. In 1978, dental examinations of elementary schoolchildren (ages 6-12) who had continuously participated in the program for 1 to 6 years showed a prevalence of 2.70 DMFS, 45% lower than the score of 4.89 DMFS for their cohorts at the baseline. The preventive program inhibited dental caries effectively in all types of surfaces, but the reduction in proximal surfaces of 85% is particularly striking. Findings of high school children (ages 13-17) in 1978, who had not participated in the elementary school program for 1-5 years, showed evidence of strong post-treatment effects. At cacti succeeding follow-up survey, benefits have continued to improve. For elementary school participants, benefits were 17.7% after 2 years, 35.3% after 4 years and 44.8% after 6 years. Weekly fluoride mouthrinsing and daily ingestion of a fluoride tablet are feasible school-based procedures for the prevention of dental caries. Combined with the use of a fluoride dentifrice at home, these procedures have a pronounced cariostatic effect. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries -- Prevention
KW - PREVENTIVE dentistry
KW - TEETH -- Care & hygiene
KW - SCHOOL children
KW - FLUORIDES
KW - FLUORINE compounds
KW - dental caries prevention
KW - fluorides
KW - school health.
N1 - Accession Number: 12057862; Horowitz, Herschel S. 1 Heifetz, Stanley B. 1 Meyers, Rhea J. 1 Driscoll, William S. 1 Shou-Hua Li, William S. 1; Affiliation: 1: National Caries Program, national Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug1980, Vol. 8 Issue 4, p177; Subject Term: DENTAL caries -- Prevention; Subject Term: PREVENTIVE dentistry; Subject Term: TEETH -- Care & hygiene; Subject Term: SCHOOL children; Subject Term: FLUORIDES; Subject Term: FLUORINE compounds; Author-Supplied Keyword: dental caries prevention; Author-Supplied Keyword: fluorides; Author-Supplied Keyword: school health.; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0528.ep12057862
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bonner, William M.
AU - West, Michael H. P.
AU - Stedman, John D.
T1 - Two-Dimensional Gel Analysis of Histones in Acid Extracts of Nuclei, Cells, and Tissues.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/08//8/1/80
VL - 109
IS - 1
M3 - Article
SP - 17
EP - 23
PB - Wiley-Blackwell
SN - 00142956
AB - Two-dimensional gel analysis of histones from extracts of nuclei, cells, and tissues is described. A discontinuous buffer system which concentrates the sample was used to increase resolution in both dimensions and also to allow the direct loading of HCl extracts of chromatin, nuclei, cells, and tissues. Stained one-dimensional gels are used as sample gels for the second dimension, cetyltrimethylammonium bromide being used to solubilize the proteins in the dye-protein complex. These methods enable one to purify proteins through acetic acid/urea/Triton, acetic acid/urea, and sodium dodecyl sulfate gels without eluting them from the gels. The method is also compatible with the use of protamine to displace histones from nuclei and nucleosomes separated in chromatin gels. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTONES
KW - PROTEINS
KW - CHROMATIN
KW - GEL electrophoresis
KW - MOLECULAR pharmacology
KW - BIOCHEMISTRY
N1 - Accession Number: 13608616; Bonner, William M. 1 West, Michael H. P. 1 Stedman, John D. 1; Affiliation: 1: Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 8/1/80, Vol. 109 Issue 1, p17; Subject Term: HISTONES; Subject Term: PROTEINS; Subject Term: CHROMATIN; Subject Term: GEL electrophoresis; Subject Term: MOLECULAR pharmacology; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Document Type: Article
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ER -
TY - JOUR
AU - Kano, Itsu
AU - Nebert, Daniel W.
T1 - Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/08//8/1/80
VL - 109
IS - 1
M3 - Article
SP - 25
EP - 31
PB - Wiley-Blackwell
SN - 00142956
AB - The subcellular distribution of aryl-hydrocarbon hydroxylase, NADPH-cytochrome c reductase, NADH :cytochrome c reductase, and NADH :cytochrome b5 reductase activities in mouse liver was studied using the biochemical membrane markers microsomal glucose-6-phosphatase, mitochondrial cytochrome c oxidase, and plasma membrane 5′-nucleotidase. The rate of appearance of activity of 3-methylcholanthrene-induced aryl-hydrocarbon hydroxylase in the microsomes of C57BL/6N mice is more than twice as rapid as that in the nuclear envelope. The nuclear fraction contains less than 1% of the total cellular activities of the hydroxylase and all three reductases. All detectable basal activity of aryl-hydrocarbon hydroxylase in the nuclear fraction of control C57BL/6N and DBA′2N and 3-methylcholanthrene-treated DBA/2N mice and all detectable activities of NADPH :cytochrome c, NADH :cytochrome c, and NADH :catochrome b5 reductase in the nuclear fraction of control and 3-methylcholanthrene-treated C57BL/6N and DBA/2N mice can be completely accounted for by the degree of microsomal fragment contamination (as assessed by the microsomal marker glucose-6-phosphatase). These data raise doubts about certain previous reports of ‘nuclear’ enzyme activities in which microsomal contamination was not taken into account. However, there is more induced activity of aryl-hydrocarbon hydroxylase in the nuclear fraction of 3-methylcholanthrene-treated C57BL/6N mice than can be accounted for by the degree of microsomal membrane contribution. The routine Ah locus is known to regulate the induction by certain polycyclic aromatic chemicals of numerous drug-metabolizing enzyme activities such as aryl-hydrocarbon hydroxylase associated with cytochrome P1-450. The expression of 3-methylcholanthrene-inducible hydroxylase in nuclear membranes, like that in microsomal membranes, thus appears to be controlled by the Ah regulatory gene. [ABSTRACT FROM AUTHOR]
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KW - ENZYMES
KW - CYTOCHROME P-450
KW - MICROSOMES
KW - SUBCELLULAR fractionation
KW - DEVELOPMENTAL pharmacology
KW - BIOCHEMISTRY
KW - ARYL hydrocarbon hydroxylases
N1 - Accession Number: 13608900; Kano, Itsu 1 Nebert, Daniel W. 1; Affiliation: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; Source Info: 8/1/80, Vol. 109 Issue 1, p25; Subject Term: ENZYMES; Subject Term: CYTOCHROME P-450; Subject Term: MICROSOMES; Subject Term: SUBCELLULAR fractionation; Subject Term: DEVELOPMENTAL pharmacology; Subject Term: BIOCHEMISTRY; Subject Term: ARYL hydrocarbon hydroxylases; Number of Pages: 7p; Document Type: Article
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ER -
TY - JOUR
AU - Hawley-Nelson, Pamela
AU - Sullivan, James E.
AU - Kung, Margaret
AU - Hennings, Henry
AU - Yuspa, Stuart H.
T1 - Optimized Conditions for the Growth of Human Epidermal Cells in Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/08//
VL - 75
IS - 2
M3 - Article
SP - 176
EP - 182
SN - 0022202X
AB - Methods have been optimized for the isolation, growth and passage of differentiating human epidermal cells in dispersed cell culture. Human neonatal foreskin epidermis was separated from dermis after floating the skin on trypsin. Keratinocytes were isolated by dissociation of epidermal sheets in calcium, magnesium-free phosphate buffered saline. Under culture conditions established for mouse keratinocytes, human epidermal cells retained epithelial morphology for 1-2 mo and could be subcultured 2-3 times. Cells exposed to modified culture conditions were tested for growth at low cell density and ability to be repeatedly subcultured while maintaining normal epithelial morphology. Optimal conditions were determined by counting the number of colonies formed 1-3 weeks after plating 0.2-1 × 104 cells/cm² and by measuring the maximum number of passages attainable with cultures plated at 105 cells/cm². Compared to tissue culture plastic, a substrate of collagen (prepared by acid extraction of rat tail tendons) increased colony formation 2-4 fold. Lowering the culture temperature from 37° to 34° or 31°C reduced colony number to 50% and 10% respectively. Serum concentrations of 10-20% yielded 2- 4 fold more colonies than lower or higher levels. Seven commercial or especially formulated media did not enhance either growth parameter. Both colony formation and number of passages were increased at pH 7.0-7.2 compared to lower or higher pH. Medium ionic calcium concentrations of 0.3-0.4 mM doubled the number of colonies and passages compared to higher or lower levels. These improvements in culture conditions enhance the suitability of human keratinocyte cultures for a number of biological studies. [ABSTRACT FROM AUTHOR]
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KW - EPIDERMIS
KW - CELL culture
KW - TRYPSIN
KW - EPITHELIUM
KW - KERATINOCYTES
KW - MORPHOLOGY
N1 - Accession Number: 12522602; Hawley-Nelson, Pamela 1 Sullivan, James E. 1 Kung, Margaret 1 Hennings, Henry 2 Yuspa, Stuart H. 2; Affiliation: 1: Microbiological Associates, Bethesda, Maryland. 2: Vitro Pathogenesis Section, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A..; Source Info: Aug80, Vol. 75 Issue 2, p176; Subject Term: EPIDERMIS; Subject Term: CELL culture; Subject Term: TRYPSIN; Subject Term: EPITHELIUM; Subject Term: KERATINOCYTES; Subject Term: MORPHOLOGY; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12522602
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ER -
TY - JOUR
AU - Stanley, John R.
AU - Hawley-Nelson, Pamela
AU - Poirier, Miriam
AU - Katz, Stephen I.
AU - Yuspa, Stuart H.
T1 - Detection of Pemphigoid Antigen, Pemphigus Antigen, and Keratin Filaments by Indirect Immunofluorescence in Cultured Human Epidermal Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/08//
VL - 75
IS - 2
M3 - Article
SP - 183
EP - 186
SN - 0022202X
AB - In order to determine whether pemphigold antigen is synthesized by epidermal cells, and whether other, normal keratinocyte, antigens are synthesized in culture, primary cultures and subsequent subcultures of human epidermal cells derived from neonatal foreskins were studied for the presence of pemphigoid antigen, pemphigus antigen and keratin filaments using indirect immunofluorescence. Twenty-four hr after plating primary cultures, pemphigoid antigen was detected as an asymmetric fluorescence on the cell membranes of rounded cells or a faint fluorescence of the cytoplasm of cells which had spread on the substrate. At later times in primary cultures and in subcultures pemphigoid antigen showed a pattern of coarsely granular fluorescence within or under the cytoplasm of many of the small cells at both the base and expanding periphery of epidermal cell colonies. Pemphigus antigen was detected mainly on the cell membranes of the larger flat cells located more superficially in the colonies. Keratin filaments were detected in cells at all levels of the epidermal colonies. Rounded cells, which had not yet spread on the substrate, displayed bright perinuclear fluorescence with keratin antibody. In cells spread on the substrate, keratin filaments often appeared to line up end-to-end with filaments of neighboring cells. No qualitative changes in fluorescence of any of these antigens could be detected through 6 subcultures. Human fibroblasts in culture did not display any of these three antigens by immunofluorescence. The finding that cultured human epidermal cells displayed these antigens with the same pattern and intensity through 6 passages indicates that pemphigoid antigen, as well as pemphigus antigen and keratin, were newly synthesized in culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - FORESKIN
KW - IMMUNOFLUORESCENCE
KW - PEMPHIGUS
KW - KERATIN
KW - CYTOPLASM
N1 - Accession Number: 12522615; Stanley, John R. 1,2 Hawley-Nelson, Pamela 3 Poirier, Miriam 4 Katz, Stephen I. 1 Yuspa, Stuart H. 4; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Laboratory of Developmental Biology, Anomalies, National Institute of Dental Research, Bethesda, Maryland, U.S.A. 3: Microbiology Associates, Bethesda, Maryland, U.S.A. 4: Vitro Pathogenesis Section, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug80, Vol. 75 Issue 2, p183; Subject Term: ANTIGENS; Subject Term: FORESKIN; Subject Term: IMMUNOFLUORESCENCE; Subject Term: PEMPHIGUS; Subject Term: KERATIN; Subject Term: CYTOPLASM; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12522615
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Robertson, W Davenport
T1 - A user-oriented approach to setting priorities for library services
JO - Special Libraries
JF - Special Libraries
Y1 - 1980/08//
VL - 71
IS - 8
M3 - Article
SP - 345
EP - 353
SN - 00386723
AB - A user-oriented model for setting priorities for services in the medium size sci/tech research library is described. A survey of the research staffs of three organizations as to their conception of library priorities is compared with the budgets and opinions of the three library directors. The survey results are consistent and show much agreement with the librarians. The model groups eleven aspects of library services into three clusters of importance with journal purchases and computerized literature searching given the highest priority. This model can be used for planning and evaluating special libraries
N1 - Accession Number: ISTA1502555; Robertson, W Davenport 1; Affiliations: 1 : Library And Information Services, National Institute Of Environmental Health Sciences, Research Triangle Park, Nc; Source Info: August 1980, Vol. 71 Issue 8, p345; Note: Update Code: 1500; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - SHAFIE, SAMIR M.
T1 - Estrogen and the Growth of Breast Cancer: New Evidence Suggests Indirect Action.
JO - Science
JF - Science
Y1 - 1980/08/08/
VL - 209
IS - 4457
M3 - Article
SP - 701
EP - 702
SN - 00368075
AB - The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures there from have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196409; SHAFIE, SAMIR M. 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/ 8/1980, Vol. 209 Issue 4457, p701; Number of Pages: 2p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - KALIN, NED H.
AU - RISCH, SAMUEL C.
AU - COHEN, ROBERT M.
AU - INSEL, THOMAS
AU - MURPHY, DENNIS L.
T1 - Dexamethasone Fails to Suppress β-Endorphin Plasma Concentrations in Humans and Rhesus Monkeys.
JO - Science
JF - Science
Y1 - 1980/08/15/
VL - 209
IS - 4458
M3 - Article
SP - 827
EP - 828
SN - 00368075
AB - In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating β-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary β-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate β-endorphin secretion in the same way. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196457; KALIN, NED H. 1; RISCH, SAMUEL C. 1; COHEN, ROBERT M. 1; INSEL, THOMAS 1; MURPHY, DENNIS L. 1; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 8/15/1980, Vol. 209 Issue 4458, p827; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - Boice, John D.
AU - Fraumeni Jr., Joseph F.
T1 - Late Effects following Isoniazid Therapy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/09//
VL - 70
IS - 9
M3 - Article
SP - 987
EP - 989
PB - American Public Health Association
SN - 00900036
AB - Abstract: Among 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide INH) for pulmonary tuberculosis no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1.090 patients who did not receive INH partly due to radiogenic breast cancer resulting from multiple chest flouroscopics to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISONIAZID
KW - DRUGS -- Side effects
KW - TUBERCULOSIS -- Treatment
KW - WOMEN -- Diseases -- Treatment
KW - ANTITUBERCULAR agents
KW - CIRRHOSIS of the liver
KW - ISONICOTINIC acid
KW - HYDRAZINE
KW - LIVER diseases
N1 - Accession Number: 4957375; Boice, John D. 1 Fraumeni Jr., Joseph F. 1; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute; Source Info: Sep90, Vol. 70 Issue 9, p987; Subject Term: ISONIAZID; Subject Term: DRUGS -- Side effects; Subject Term: TUBERCULOSIS -- Treatment; Subject Term: WOMEN -- Diseases -- Treatment; Subject Term: ANTITUBERCULAR agents; Subject Term: CIRRHOSIS of the liver; Subject Term: ISONICOTINIC acid; Subject Term: HYDRAZINE; Subject Term: LIVER diseases; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 3p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Nakamura, K.
T1 - Conversion of immune response patterns from high to low and low to high by an RNase-sensitive thymocyte extract.
JO - Immunology
JF - Immunology
Y1 - 1980/09//
VL - 41
IS - 1
M3 - Article
SP - 25
EP - 35
PB - Wiley-Blackwell
SN - 00192805
AB - In vitro immune responses to human serum albumin (HSA) and synthetic polypeptides (T,G)-A-L, and (H,G)-A L, associated with the maturation IgG-forming plasma cells were studied in relation to thymic low molecular weight RNA. This RNA, from normal low-responder animals to these antigens, converted high-responder bone marrow cells to low responders, whereas RNA from high responders converted low-responder bone marrow cells to high responders. These changes of immune response patterns were observed not only in the combination of allogeneic mouse cells and RNA, but also in xenogeneic rat and mouse systems. Thymic RNA from low-responder animals had no suppressive activity to high-responder RNA, when both were added together to one dish with antigen. High doses (⊗50) of low-responder thymic RNA stimulated the same immune response level as a regular amount of high-responder thymic RNA. Intact thymocytes derived from low-responder mice added together with high-responder thymic RNA did not suppress immune response of high-responder bone marrow cultures. Intact allogeneic thymocytes also induced the same response as allogeneic thymic RNA. These results indicate that humoral immune responses can be influenced by thymic RNA derived from normal animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGY
KW - IMMUNE system
KW - IMMUNE response
KW - BONE marrow
KW - PLASMA cells
KW - RNA
N1 - Accession Number: 13971206; Nakamura, K. 1,2; Affiliation: 1: Immunology Branch, Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Molecular Biology Laboratory, Department of Biochemistry, Kilasato University School of Medicine, 1-15-1, Kilasato, Sagamihara, Kanagawa, Japan 228; Source Info: Sep80, Vol. 41 Issue 1, p25; Subject Term: IMMUNOLOGY; Subject Term: IMMUNE system; Subject Term: IMMUNE response; Subject Term: BONE marrow; Subject Term: PLASMA cells; Subject Term: RNA; Number of Pages: 11p; Illustrations: 6 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, C. J.
T1 - Maternal-foetal interaction, antibody formation, and metabolic response in mice immunized with pneumococcal polysaccharides.
JO - Immunology
JF - Immunology
Y1 - 1980/09//
VL - 41
IS - 1
M3 - Article
SP - 45
EP - 54
PB - Wiley-Blackwell
SN - 00192805
AB - The maternal transfer of pneumococcal polysaccharides to foetus, as well as the antibody formation and metabolic response were studied in mice exposed to pneumococcal polysaccharides during pregnancy. Type 19 and type 57 pneumococcal polysaccharides display cross-placental transfer to foetus. These polysaccharides also transfer through mother's milk to neonates. Maternal immunization of type 19 polysaccharide during pregnancy induced higher antibody formation in the offspring than the group from non-immunized mothers. Young mice, which received a second dose of polysaccharide at 2 weeks of age, showed a higher antibody response than those which did not receive polysaccharide. Treatment of mothers with anti-lymphocyte serum, following by administration of polysaccharide, significantly increased the neonatal immune response to the polysaccharide. Treatment of the mother with a high dose of type 19 or type 57 polysaccharide did not cause significant changes in neonatal growth and organ weights. The offspring from mothers treated with high doses of these polysaccharides did not exhibit abnormalities in chemical contents of their tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGY
KW - MICE
KW - METABOLISM
KW - IMMUNOGLOBULINS
KW - PNEUMOCOCCAL vaccine
KW - POLYSACCHARIDES
N1 - Accession Number: 13971224; Lee, C. J. 1; Affiliation: 1: Bureau of Biologics, National Institutes of Health, Bethesda, Maryland U.S.A.; Source Info: Sep80, Vol. 41 Issue 1, p45; Subject Term: IMMUNOLOGY; Subject Term: MICE; Subject Term: METABOLISM; Subject Term: IMMUNOGLOBULINS; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: POLYSACCHARIDES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wei, L. J.
T1 - A Generalized Gehan and Gilbert Test for Paired Observations That Are Subject to Arbitrary Right Censorship.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1980/09//
VL - 75
IS - 371
M3 - Article
SP - 634
SN - 01621459
AB - An asymptotically distribution-free test, along the line of Gehan (1965) and Gilbert (1962), for paired observations that are subject to arbitrary right censorship is proposed. This test is shown to be more powerful than the sign test under a bivariate exponential model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - NONPARAMETRIC statistics
KW - STATISTICAL reliability
KW - PROBABILITY theory
KW - STANDARD deviations
KW - STATISTICAL hypothesis testing
KW - ASYMPTOTIC distribution (Probability theory)
KW - CHARACTERISTIC functions
KW - Asymptotically distribution-free test
KW - Bivariate exponential model
KW - Gehan and Gilbert test
KW - Right censorship.
N1 - Accession Number: 4600355; Wei, L. J. 1; Affiliations: 1: National Cancer Institute, 5C09 Landow Bldg., Bethesda, MD 20205.; Issue Info: Sep80, Vol. 75 Issue 371, p634; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: STATISTICAL reliability; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STANDARD deviations; Thesaurus Term: STATISTICAL hypothesis testing; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: CHARACTERISTIC functions; Author-Supplied Keyword: Asymptotically distribution-free test; Author-Supplied Keyword: Bivariate exponential model; Author-Supplied Keyword: Gehan and Gilbert test; Author-Supplied Keyword: Right censorship.; Number of Pages: 4p; Document Type: Article
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DB - buh
ER -
TY - JOUR
AU - Halperin, Max
AU - Ware, James H.
AU - Wu, Margaret
T1 - Conditional Distribution-Free Tests for the Two-Sample Problem in the Presence of Right Censoring.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1980/09//
VL - 75
IS - 371
M3 - Article
SP - 638
SN - 01621459
AB - Two-sample rank tests for survival data in the presence of arbitrary right censoring are considered. We distinguish between administrative censoring, arising because survival study participants do not enter as a cohort, and censoring due to "loss to follow-up." We show how conditionally distribution-free tests can be constructed in certain situations. Conditional versions of the generalized Wilcoxon and Mantel statistics are shown to be asymptotically normal in the conditional reference set, but with modified means and variances. Efficiency of these tests relative to asymptotically distribution-free competitors is unity, providing the censoring distributions are discrete, the same for both samples, and providing loss-to-follow-up (LFU) distributions are the same for the two samples. When these assumptions do not hold, efficiency can deteriorate considerably, being poorest, other things being equal, when the censoring distribution is continuous. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONPARAMETRIC statistics
KW - ANALYSIS of variance
KW - DISTRIBUTION (Probability theory)
KW - STATISTICS
KW - PROBABILITY theory
KW - SURVIVAL analysis (Biometry)
KW - FAILURE time data analysis
KW - ASYMPTOTIC distribution (Probability theory)
KW - BIOMETRY
KW - Censoring
KW - Distribution free.
KW - Mantel-Haenszel test
KW - Survival analysis
KW - Two-sample problem
KW - Wilcoxon test
N1 - Accession Number: 4600390; Halperin, Max 1; Ware, James H. 2; Wu, Margaret 3; Affiliations: 1: Research Professor, Department of Statistics, George Washington University, Bethesda, MD 20014.; 2: Associate Professor, Department of Biostatistics, Harvard University, Boston, MA 02115.; 3: Mathematical Statistician, Mathematical and Applied Statistics Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20205.; Issue Info: Sep80, Vol. 75 Issue 371, p638; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: SURVIVAL analysis (Biometry); Subject Term: FAILURE time data analysis; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: BIOMETRY; Author-Supplied Keyword: Censoring; Author-Supplied Keyword: Distribution free.; Author-Supplied Keyword: Mantel-Haenszel test; Author-Supplied Keyword: Survival analysis; Author-Supplied Keyword: Two-sample problem; Author-Supplied Keyword: Wilcoxon test; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hirata, Fusao
AU - Axelrod, Julius
T1 - Phospholipid Methylation and Biological Signal Transmission.
JO - Science
JF - Science
Y1 - 1980/09/05/
VL - 209
IS - 4461
M3 - Article
SP - 1082
EP - 1090
SN - 00368075
N1 - Accession Number: 85196563; Hirata, Fusao 1; Axelrod, Julius; Affiliations: 1: Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 9/ 5/1980, Vol. 209 Issue 4461, p1082; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Land, Charles E.
T1 - Estimating Cancer Risks from Low Doses of Ionizing Radiation.
JO - Science
JF - Science
Y1 - 1980/09/12/
VL - 209
IS - 4462
M3 - Article
SP - 1197
EP - 1203
SN - 00368075
N1 - Accession Number: 85266533; Land, Charles E. 1; Affiliations: 1: Health Statistician, Environmental Epidemiology Branch of National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 9/12/1980, Vol. 209 Issue 4462, p1197; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SINGER, MAXINE
T1 - Recombinant DNA Revisited.
JO - Science
JF - Science
Y1 - 1980/09/19/
VL - 209
IS - 4463
M3 - Article
SP - 1318
EP - 1318
SN - 00368075
N1 - Accession Number: 85196608; SINGER, MAXINE 1; Affiliations: 1: Chief, Laboratory of Biochemistry, National Cancer Institute, Bethesda, A&ryland 20205; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1318; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leder, Philip
AU - Hansen, J. Norman
AU - Konkel, David
AU - Leder, Aya
AU - Nishioka, Yutaka
AU - Talkington, Carol
T1 - Mouse Globin System: A Functional and Evolutionary Analysis.
JO - Science
JF - Science
Y1 - 1980/09/19/
VL - 209
IS - 4463
M3 - Article
SP - 1336
EP - 1342
SN - 00368075
N1 - Accession Number: 85196612; Leder, Philip 1; Hansen, J. Norman 1; Konkel, David 1; Leder, Aya 1; Nishioka, Yutaka 1; Talkington, Carol 1; Affiliations: 1: Investigators, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1336; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Liu, Chih-Ping
AU - Tucker, Philip W.
AU - Mushinski, J. Frederic
AU - Blattner, Frederick R.
T1 - Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D.
JO - Science
JF - Science
Y1 - 1980/09/19/
VL - 209
IS - 4463
M3 - Article
SP - 1348
EP - 1353
SN - 00368075
N1 - Accession Number: 85196614; Liu, Chih-Ping 1; Tucker, Philip W. 2,3; Mushinski, J. Frederic 4; Blattner, Frederick R. 5; Affiliations: 1: Postdoctoral Fellow in Laboratory of Genetics, University of Wisconsin-Madison, Madison 53706; 2: Assistant Professor, Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216; 3: Associate Professor, Department of Microbiology, University of Texas Southwestern Medical School, Dallas 75235.; 4: Senior Investigator, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 5: Associate Professor of Genetics, Laboratory of Genetics, University of Wisconsin- Madison, Madison 53706; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1348; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tucker, Philip W.
AU - Liu, Chih-Ping
AU - Mushinski, J. Frederic
AU - Blattner, Frederick R.
T1 - Mouse Immunoglobulin D: Messenger RNA and Genomic DNA Sequences.
JO - Science
JF - Science
Y1 - 1980/09/19/
VL - 209
IS - 4463
M3 - Article
SP - 1353
EP - 1360
SN - 00368075
N1 - Accession Number: 85196615; Tucker, Philip W. 1; Liu, Chih-Ping 2; Mushinski, J. Frederic 3; Blattner, Frederick R. 4; Affiliations: 1: Assistant Professor, Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216; 2: Postdoctoral Fellow, Laboratory of Genetics, University of Wisconsin-Madison, Madison 53706; 3: Senior Investigator, Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 4: Associate Professor of Genetics, Laboratory of Genetics, University of Wisconsin- Madison, Madison 53706; Issue Info: 9/19/1980, Vol. 209 Issue 4463, p1353; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RISCH, SAMUEL C.
AU - COHEN, ROBERT M.
AU - JANOWSKY, DAVID S.
AU - KALIN, NED H.
AU - MURPHY, DENNIS L.
T1 - Mood and Behavioral Effects of Physostigmine on Humans Are Accompanied by Elevations in Plasma, β-Endorphin and Cortisol.
JO - Science
JF - Science
Y1 - 1980/09/26/
VL - 209
IS - 4464
M3 - Article
SP - 1545
EP - 1546
SN - 00368075
AB - Administration of physostigmine to normal volunteers produced significant elevations in plasma cortisol and β-endorphin immunoreactivity as well as alterations in mood, cognition, and behavior. These observations might be explained by a cholinergically mediated stress syndrome. However, peak elevations in plasma β- endorphin immunoreactivity (but not in plasma cortisol) were significantly correlated with physostigmine-induced increases in depression ratings. These results suggest that a cholinergically mediated, β-endorphin pathway may be involved in the observed affective changes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85196680; RISCH, SAMUEL C. 1; COHEN, ROBERT M. 1; JANOWSKY, DAVID S. 2; KALIN, NED H. 3; MURPHY, DENNIS L. 3; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla 92161; 3: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 9/26/1980, Vol. 209 Issue 4464, p1545; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simpson, Ian Alexander
AU - Pfeuffer, Thomas
T1 - Functional Desensitisation of β-Adrenergic Receptors of Avian Erythrocytes by Catecholamines and Adenosine 3', 5'-Phosphate.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/10//10/1/80
VL - 111
IS - 1
M3 - Article
SP - 111
EP - 116
PB - Wiley-Blackwell
SN - 00142956
AB - Prolonged exposure to β-adrenergic agonists of pigeon erythrocytes causes a reversible loss (70%) of catecholamine-stimulated adenylate cyclase activity without reduction in the number of β-adrenergic receptors. In addition a less pronounced decrease in non-stimulated and NaF-stimulated adenylate cyclase activity (15–22%) is observed, appearing at different agonist concentrations and at a different rate. Dibutyryladenosine 3′.5′-phosphate and the phosphodiesterase inhibitor methyl-isobutylxanthine partially mimick the action of the β-adrenergic agonist, thus pointing to a possible role of adenosine 3′,5′-phosphate in establishing desensitization. When adenylate cyclase from desensitized cells is stimulated with 5′-guanylyl-imidodiphosphate in the presence or absence of catecholamines the lag period preceding the attainment of maximal activity is extended. Likewise the rate of reversal by GTP or ATP of persistent activation of adenylate cyclase is slowed down. This is therefore interpreted to mean that the loss in hormonal stimulation on treatment of pigeon red blood cells with β-adrenergic agonists is due to a delayed exchange of GDP against GTP on the regulatory GTP-binding protein. Furthermore, we conclude that events causing the refractory state in avian erythrocytes should occur at a site distal to the β-adrenergic receptor. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BETA adrenoceptors
KW - ADRENERGIC receptors
KW - ADENINE nucleotides
KW - ADENOSINE
KW - CATECHOLAMINES
KW - BIOCHEMISTRY
N1 - Accession Number: 13618034; Simpson, Ian Alexander 1 Pfeuffer, Thomas 2; Affiliation: 1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20014 2: Physiologisch-Chemisches Institut der Jtilius-Maximilians-Universität Würzburg, Koellikerstraße 2, D-8700 Würzburg, Federal Republic of Germany; Source Info: 10/1/80, Vol. 111 Issue 1, p111; Subject Term: BETA adrenoceptors; Subject Term: ADRENERGIC receptors; Subject Term: ADENINE nucleotides; Subject Term: ADENOSINE; Subject Term: CATECHOLAMINES; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawley, Thomas J.
AU - Gorevic, Peter D.
AU - Hamburger, Max I.
AU - Franklin, Edward C.
AU - Frank, Michael M.
T1 - Multiple Types of Immune Complexes in Patients with Mixed Cryoglobulinemia.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1980/10//
VL - 75
IS - 4
M3 - Article
SP - 297
EP - 301
SN - 0022202X
AB - The sera of 13 patients with mixed cryoglobulinemia were examined for the presence of circulating immune complexes with the 125I-C1q binding assay before and after precipitation of cryoglobulins. All 13 patients had increased C1q binding activity(>10%) prior to cryoprecipitation (mean C1q binding activity =69%) and 10 of 13 had increased C1q binding activity after precipitation and removal of cryoglobulin (mean C1q binding activity = 41%). Decrements in serum C1q binding activity caused by cryoprecipitation ranged from minimal to marked (1-73%). Since all of these sera contained IgM rheumatoid factor, 7 were treated with 2-mercaptoethanol, known to dissociate 19S IgM into its subunits, and then tested for C1q binding activity and rheumatoid factor. 2-mercaptoethanol eliminated rheumatoid factor activity in all cases, but C1q binding activity remained elevated in 6 to 7 sera, thus indicating the presence of immune complexes distinct form 19S IgM rheumatoid factor complexes. By contrast absorption of 9 mixed cryoglobulinemia sera with solid-phase protein A resulted in the disappearance of immune complex-like material from the test sera, suggesting that IgG is a major constituent of the C1q binding material. Addition of eluate from the solid phase protein A to normal sera resulted in the appearance of increased C1q binding activity. Hepatitis B surface antigen was detected in the protein A eluate of two of six patient tested, and antibody to hepatitis B surface antigen was detected in the protein A eluate of a third patient. These findings indicate that in addition to cryoglobulins patients with mixed cryoglobulinemia have circulating immune complexes that are noncryoprecipitable. The immune complexes contain predominantly IgG and are, in most cases, distinct form 19S IgM rheumatoid factor complexes. In some cases the immune complexes may contain hepatitis B surface antigen or antibody. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYOGLOBULINEMIA
KW - IMMUNE complexes
KW - CRYOGLOBULINS
KW - RHEUMATOID factor
KW - PROTEIN binding
KW - CELL surface antigens
N1 - Accession Number: 12530883; Lawley, Thomas J. 1 Gorevic, Peter D. 2 Hamburger, Max I. 3 Franklin, Edward C. 4 Frank, Michael M. 3; Affiliation: 1: Dermatology Branch, National Cancer Institute. 2: Department of Medicine State University of New York, Stony Brook, New York. 3: Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland. 4: New York University School of Medicine, New York, U.S.A..; Source Info: Oct80, Vol. 75 Issue 4, p297; Subject Term: CRYOGLOBULINEMIA; Subject Term: IMMUNE complexes; Subject Term: CRYOGLOBULINS; Subject Term: RHEUMATOID factor; Subject Term: PROTEIN binding; Subject Term: CELL surface antigens; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12530883
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thune, Elizabeth S.
AU - Manderscheid, Ronald W.
AU - Silbergeld, Sam
T1 - STATUS OR SEX ROLES AS DETERMINANTS OF INTERACTION PATTERNS IN SMALL, MIXED-SEX GROUPS.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1980/10//
VL - 112
IS - 1
M3 - Article
SP - 51
PB - Taylor & Francis Ltd
SN - 00224545
N1 - Accession Number: 5388064; Thune, Elizabeth S. 1 Manderscheid, Ronald W. 1 Silbergeld, Sam 1; Affiliation: 1: Mental Health Study Center, National Institute of Mental Health, Adelphi, Maryland; Source Info: Oct1980, Vol. 112 Issue 1, p51; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42218-028
AN - 2013-42218-028
AU - Curtz, Elizabeth
T1 - Review of Usable knowledge: Social science and social problem solving.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1980/10//
VL - 50
IS - 4
SP - 744
EP - 745
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42218-028. Partial author list: First Author & Affiliation: Curtz, Elizabeth; Mental Health Study Center, National Institute Of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Decision Making; Problem Solving; Social Issues; Social Sciences. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Lindblom, Charles E.; Cohen, David K. Usable knowledge: Social science and social problem solving=129 pp. $10.00 ($3.95 paper). Yale University Press, New Haven; 1979. Page Count: 2. Issue Publication Date: Oct, 1980.
AB - Reviews the book, Usable Knowledge: Social Science and Social Problem Solving by Charles E. Lindblom and David K. Cohen (1979). The authors argued that the production of usable knowledge through professional social inquiry (PSI) requires the reassessment of two fundamental assumptions. The problem which the authors pose for practitioners of professional social inquiry is how to use the tools and resources of social science to produce material appropriate and useful to varied decision-making processes. The book contains specific suggestion on how this Problem might be tackled and calls for a halt to the proliferation of social science research that addresses social problems without being tailored to fit the problem resolution process. This failure to write a book that is engaging and interesting to read may be unimportant. The authors dismiss as parochial and cosmetic the criticism that 'social scientists don't write attractively' Nonetheless is too often tme, and it makes Usable Knowledge a hook that is of importance to pPSI, but of little interest to other readers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - professional social inquiry
KW - social science
KW - social problem solving
KW - decision making
KW - 1980
KW - Decision Making
KW - Problem Solving
KW - Social Issues
KW - Social Sciences
KW - 1980
U2 - Lindblom, Charles E.; Cohen, David K. (1979); Usable knowledge: Social science and social problem solving; 129 pp. $10.00 ($3.95 paper). Yale University Press, New Haven
DO - 10.1037/h0098896
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LIPSKY, JAMES J.
AU - LAKE, C. R.
AU - STERNBERG, D. E.
AU - KAMMEN, D. P. VAN
AU - BALLENGER, J. C.
AU - ZIEGLER, M. G.
AU - POST, R. M.
AU - KOPIN, I. J.
AU - BUNNEY, W. E.
T1 - Elevated Cerebrospinal Fluid Norepinephrine in Schizophrenics: Confounding Effects of Treatment Drugs.
JO - Science
JF - Science
Y1 - 1980/10/03/
VL - 210
IS - 4465
M3 - Article
SP - 97
EP - 97
SN - 00368075
N1 - Accession Number: 85196745; LIPSKY, JAMES J. 1; LAKE, C. R. 2; STERNBERG, D. E. 3; KAMMEN, D. P. VAN 4; BALLENGER, J. C. 5; ZIEGLER, M. G. 6,7; POST, R. M. 8; KOPIN, I. J. 9; BUNNEY, W. E. 8; Affiliations: 1: Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 2: Department of Psychiatry and Pharmacology, Uniformed Services University, Health Sciences, Bethesda, Maryland 20014; 3: Department of Psychiatry, Yale University, New Haven, Connecticut 06519; 4: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014; 5: Department of Psychiatry, University of Virginia, Charlottesville 22903; 6: Department of Clinical Pharmacology, University of Texas Medical Branch, Galveston 77550; 7: Department of Medicine, University of Texas Medical Branch, Galveston 77550; 8: Biological Psychiatry Branch, National Institute of Mental Health; 9: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 10/ 3/1980, Vol. 210 Issue 4465, p97; Number of Pages: 3/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SOTELO, J.
AU - GIBBS JR., C. J.
AU - GAJDUSEK, D. C.
T1 - Autoantibodies Against Axonal Neurofilaments in Patients with Kuru and Creutzfeldt-Jakob Disease.
JO - Science
JF - Science
Y1 - 1980/10/10/
VL - 210
IS - 4466
M3 - Article
SP - 190
EP - 193
SN - 00368075
AB - The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in high titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is thefirst evidence of an immune reaction in the spongiform encephalopathies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266592; SOTELO, J. 1,2; GIBBS JR., C. J. 1; GAJDUSEK, D. C. 1; Affiliations: 1: Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: Visiting Scientist, Instituto Nacional de Neurologia, Insurgentes Sur 3877, Mexico 22 D.F.; Issue Info: 10/10/1980, Vol. 210 Issue 4466, p190; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Picton, Colin
AU - Klee, Claude B.
AU - Cohen, Philip
T1 - Phosphorylase Kinase from Rabbit Skeletal Muscle: Identification of the Calmodulin-Binding Subunits.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1980/10/15/
VL - 111
IS - 2
M3 - Article
SP - 553
EP - 561
PB - Wiley-Blackwell
SN - 00142956
AB - Phosphorylase kinase has the structure (αβγδ)4 where the δ-subunit is identical to the calcium-binding protein termed calmodulin [Shenolikar et al. (1979) Eur. J. Biochem. 100, 329–337]. The β-subunit was tightly bound to phosphorylase kinase in the absence of calcium ions, and its rate of exchange with [14C]calmodulin was only 15% per week. The δ-subunit remained associated with phophorylase kinase in the presence of 8 M urea provided that calcium ions were present and this property enabled electrophoretic techniques to be used which demonstrated that the δ-subunit was associated with the γ-subunit. This finding was confirmed by cross-linking experiments with dimethylsuberimidate which resulted in the formation of a γδ complex. Phosphorylase kinase was shown to bind one additional molecule of calmodulin per αβγδ unit, termed the δ′-subunit. Glycerol gradient centrifugation in the presence of [14C]calmodulin indicated that the interaction of the δ′-subunit with phosphorylase kinase only occurred in the presence of calcium ions, and that the Kd value was near 0.01 μM. This was similar to the concentration of δ′-subunit which produced half-maximal activation. The δ′-subunit did not remain associated with phosphorylase kinase in the presence of 8 M urea, either in the presence or absence of calcium ions. The very slow exchange between the δ-subunit and [14C]calmodulin, and the calcium-dependent binding of the δ′-subunit allowed cross-linking experiments to be used which demonstrated that the δ′-subunit was bound to both the α and β subunits. This result was supported by the finding that selective proteolysis of either the α-subunit, or the α and β subunits, decreased or abolished the ability of phosphorylase kinase to bind to calmodulin-Sepharose. The roles of the different subunits in the regulation of phosphorylase kinase activity are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinases
KW - CALCIUM-binding proteins
KW - PROTEIN binding
KW - CALMODULIN
KW - PHOSPHORYLASES
KW - CALCIUM ions
KW - ELECTROPHORESIS
N1 - Accession Number: 13619336; Picton, Colin 1 Klee, Claude B. 2 Cohen, Philip 1; Affiliation: 1: Department of Biochemistry, University of Dundee, Medical Sciences Institute, Dundee, Great Britain, DD1 4HN 2: National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20014; Source Info: 10/15/80, Vol. 111 Issue 2, p553; Subject Term: PROTEIN kinases; Subject Term: CALCIUM-binding proteins; Subject Term: PROTEIN binding; Subject Term: CALMODULIN; Subject Term: PHOSPHORYLASES; Subject Term: CALCIUM ions; Subject Term: ELECTROPHORESIS; Number of Pages: 9p; Illustrations: 4 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Elin, Ronald J.
T1 - Instrumentation in Clinical Chemistry.
JO - Science
JF - Science
Y1 - 1980/10/17/
VL - 210
IS - 4467
M3 - Article
SP - 286
EP - 289
SN - 00368075
N1 - Accession Number: 85361663; Elin, Ronald J. 1; Affiliations: 1: Clinical Chemistry Service, and chief, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/17/1980, Vol. 210 Issue 4467, p286; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - IWASA, KUNIHIKO
AU - TASAKI, ICHIJI
AU - GIBBONS, ROBERT C.
T1 - Swelling of Nerve Fibers Associated with Action Potentials.
JO - Science
JF - Science
Y1 - 1980/10/17/
VL - 210
IS - 4467
M3 - Article
SP - 338
EP - 339
SN - 00368075
AB - Swelling of nerve fibers during the action potential was demonstrated by three different methods. Generation of a propagated nerve impulse in a crab nerve produced an outward movement of 50 to 100 angstroms of the nerve surface and a rise in swelling pressure on the order of 5 dynes per square centimeter. In squid giant axons, the amplitude of the observed outward movement of the surface was small. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361690; IWASA, KUNIHIKO 1,2; TASAKI, ICHIJI 1,2; GIBBONS, ROBERT C. 1,2; Affiliations: 1: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 10/17/1980, Vol. 210 Issue 4467, p338; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - VOUK, V. B.
T1 - Toxicology.
JO - Science
JF - Science
Y1 - 1980/10/24/
VL - 210
IS - 4468
M3 - Article
SP - 418
EP - 419
SN - 00368075
N1 - Accession Number: 85266627; VOUK, V. B. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 10/24/1980, Vol. 210 Issue 4468, p418; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - ROTH, JAN J.
AU - GERN, WILLIAM A.
AU - ROTH, E. CAROL
AU - RALPH, CHARLES L.
AU - JACOBSON, ELLIOTT
T1 - Nonpineal Melatomn in the Alligator (Alligator mississippiensis).
JO - Science
JF - Science
Y1 - 1980/10/31/
VL - 210
IS - 4469
M3 - Article
SP - 548
EP - 550
SN - 00368075
AB - All living and most fossil representatives of the reptilian subclass Archosauria lack pineal bodies. Arrhythmic, low-level, nonpineal melatonin is present, however, in the blood of Alligator mississippiensis. Although pineal bodies have been implicated in circadian phenomena, these results suggest that arrhytmic melatonin in alligators may not be involved incircadian events and indicate that the pineal is not the only source of the hormone melatonin. The evolutionary loss of the pineal in Archosauria occurred during the Mesozoic, and era noted for its seasonal stability. Arrhythmic melatonin titers inalligators and pineal loss in alligators and other archosaurs may be related to Mesozoic seasonal stability. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 85266677; ROTH, JAN J. 1; GERN, WILLIAM A. 2; ROTH, E. CAROL 3; RALPH, CHARLES L. 4; JACOBSON, ELLIOTT 5; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Zoology, University of Wyoming, Laramie 82071; 3: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health; 4: Department of Zoology and Entomology, Colorado State University, Fort Collins 80523; 5: Department of Laboratory Animal and Wildlife Medicine, College of Veterinary Medicine, J. Hillis Miller Health Center, University of Florida, Gainesville 32610; Issue Info: 10/31/1980, Vol. 210 Issue 4469, p548; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hare, J. A.
AU - Ahmed, A.
AU - Sell, K. W.
T1 - In vitro and in vivo response of lymphoid cells from LHC hamsters to murine thymus-independent and thymus-dependent antigens.
JO - Immunology
JF - Immunology
Y1 - 1980/11//
VL - 41
IS - 3
M3 - Article
SP - 705
EP - 714
PB - Wiley-Blackwell
SN - 00192805
AB - Lymphoid cell populations (spleen, lymph node, peripheral blood, thymus, and bone marrow) from LHC inbred hamsters were studied in order to characterize further the immune response of this species. The direct PFC response to several thymic-dependent or thymic-independent antigens was evaluated. A specific direct PFC response occurred 4 days after immunization with SRBC, DNP-BSA, DNP-lys-Ficoll, TNP-LPS, TNP-BA, and SSS-III. Attempts to induce a polyclonal antibody response with LPS, TNP-LPS, SSS-III, and DNP-lys-Ficoll were unsuccessful. A weak polyclonal response was induced with TNP-BA. Spleen cells and PBL responded strongly in vitro to the T-cell mitogens Con A and PHA-P, but gave weak at\d inconsistent responses to the B-cell mitogens LPS and PI-PC. LHC hamster lymphoid cell populations bore sIg and receptors for C3 (EAC rosettes) in approximately the same ratio as various murine species. However, the profile of the number of cells bearing low-to-intermediate densities of sIg differed significantly from those of murine species when analysed with the FACS. There was a sharp reduction in the number of cells with low-to-intermediate densities of sIg. These data suggest that B cells in this strain and species lack the ability to translate signals which lead to polyclonal antibody synthesis or lack the appropriate populations of B cells that have membrane receptors for mitogens which are thought to induce such activity in murine systems and provide evidence for separate signals that induce thymus-independent and mitogenic responses. The importance of this model for studying mechanisms involved in B-cell activation is discussed. [ABSTRACT FROM AUTHOR]
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KW - IMMUNE response
KW - ANTIGENS
KW - T cells
KW - B cells
KW - LYMPHOID tissue
KW - THYMUS
N1 - Accession Number: 13988512; Hare, J. A. 1,2,3 Ahmed, A. 4 Sell, K. W. 1,2,3; Affiliation: 1: Department of Biology, Linfield College, McMinnville, Oregon 2: Department of Immunology, Naval Medical Research Institute, Bethesda, Maryland 3: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 4: Department of Immunology, Merck Institute for Therapeutic Research, P.O. Box 2000, Rahway, New Jersey 07065, U.S.A.; Source Info: Nov80, Vol. 41 Issue 3, p705; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: B cells; Subject Term: LYMPHOID tissue; Subject Term: THYMUS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hunter, Valerie A.
AU - Knittel, M. D.
AU - Fryer, J. L.
T1 - Stress-induced transmission of Yersinia ruckeri infection from carriers to recipient steelhead trout Salmo gairdneri Richardson.
JO - Journal of Fish Diseases
JF - Journal of Fish Diseases
Y1 - 1980/11//
VL - 3
IS - 6
M3 - Article
SP - 467
EP - 472
PB - Wiley-Blackwell
SN - 01407775
AB - The transmission of Yersinia ruckeri has been investigated in steelhead trout using asymptomatic carriers of the causative bacterium of enteric redmouth disease. It was found that unstressed carrier fish did not transmit the bacterium to recipient fish to cause either an epizootic or produce new carrier fish, However, when the carriers were stressed with heat, the bacterium was transmitted from the carrier to recipient fish producing a lower intestinal carrier state but no deaths. Examination of experimentally infected fish to determine the number of carriers among the survivors indicated that the frequency varied as a function of time following infection. When immunized fish were challenged with Y. ruckeri they became temporary carriers of the bacterium for up to 3 days; but were not able to transmit the infection to healthy recipient fish. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Fish Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YERSINIA
KW - TROUT
KW - BACTERIA
KW - CARRIER state (Communicable diseases)
KW - COMMUNICABLE diseases in animals
KW - DEATH
N1 - Accession Number: 15406467; Hunter, Valerie A. 1 Knittel, M. D. 2 Fryer, J. L. 3; Affiliation: 1: Laboratory of Molecular Biology, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U. S. A. 2: Environmental Protection Agency, Corvallis Environmental Research Laboratory Freshwater Division, Toxicology Branch, Corvallis, Oregon, U.S.A. 3: Department of Microbiology, Oregon State University, Corvallis, Oregon, U.S.A.; Source Info: Nov1980, Vol. 3 Issue 6, p467; Subject Term: YERSINIA; Subject Term: TROUT; Subject Term: BACTERIA; Subject Term: CARRIER state (Communicable diseases); Subject Term: COMMUNICABLE diseases in animals; Subject Term: DEATH; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whitehead, William B.
T1 - Perception of Gastric Contractions and Self-Control of Gastric Motility.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1980/11//
VL - 17
IS - 6
M3 - Article
SP - 552
EP - 558
SN - 00485772
AB - The hypothesis was that self-control of a visceral response is dependent on ability to perceive occurrence of the response. Subjects were asked to judge whether or not a signal light coincided with a stomach contraction on each of approximately 200 trials. In a different session heart beat perception was tested by asking subjects to judge whether or not signal light flashes coincided with heart beats. Subjects then were tested for ability to increase and to decrease gastric motility prior to biofeedback training, after which half received 4 hrs of visual feedback while the others practiced without feedback. Control of motility without feedback was subsequently retested. Initially, subjects were unable to control gastric motility, but with feedback they could increase motility on command. Ability to perceive gastric contractions was unrelated to control of gastric motility before, during, or following biofeedback training, indicating that self-control of a visceral response is not dependent on perceptual sensitivity. Perception of stomach contractions correlated significantly (r = .51) with perception of heart beats, suggesting that there may be a generalized tendency to be aware of or to attend to visceral events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STOMACH -- Motility
KW - SELF-control
KW - VISCERAL reflex
KW - HEART beat
KW - BIOFEEDBACK training
KW - Biofeedback.
KW - Calibration theory
KW - Gastric motility
KW - Heart rate
KW - Interoception
KW - Stomach
KW - Visceral perception
N1 - Accession Number: 11104296; Whitehead, William B. 1,2,3; Affiliation: 1: Department of Psychiatry, Johns Hopkins University School of Medicine. 2: Gerontology Research Center (Baltimore), National Institute on Aging, National Institute of Health, Education. 3: Welfare, Bethesda, and Baltimore City Hospitals, Baltimore.; Source Info: Nov1980, Vol. 17 Issue 6, p552; Subject Term: STOMACH -- Motility; Subject Term: SELF-control; Subject Term: VISCERAL reflex; Subject Term: HEART beat; Subject Term: BIOFEEDBACK training; Author-Supplied Keyword: Biofeedback.; Author-Supplied Keyword: Calibration theory; Author-Supplied Keyword: Gastric motility; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Interoception; Author-Supplied Keyword: Stomach; Author-Supplied Keyword: Visceral perception; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1469-8986.ep11104296
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SHINOHARA, TOSHIMICHI
AU - PIATIGORSKY, JORAM
T1 - Persistence of Crystallin Messenger RNA's with Reduced Translation in Hereditary Cataracts in Mice.
JO - Science
JF - Science
Y1 - 1980/11/21/
VL - 210
IS - 4472
M3 - Article
SP - 914
EP - 916
SN - 00368075
AB - In vitro translation experiments showed that the lens fiber cells of two hereditary cataracts in mice (Nakano and Philly) possessed a full complement of crystallin messenger RNA's, despite severely reduced synthesis of crystallin in these cells. The reduction in synthesis in the lens fiber cells correlated with the increase in Na+ and the decrease in K+, which occurs during cataractogenesis. In contrast to the fiber cells, the epithelial cells continued to synthesize crystallins in the cataractous lenses. Crystallin synthesis was stimulated in the fiber cells by raising the K+ concentration and lowering the Na+ concentration in the cultured lenses. The reduction in crystallin synthesis in the initial stages of cataractogenesis in the Nakano and Philly lenses thus appears to be due to poor utilization of crystallin messenger RNA's in the fiber cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266805; SHINOHARA, TOSHIMICHI 1; PIATIGORSKY, JORAM 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 11/21/1980, Vol. 210 Issue 4472, p914; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SEKIZAWA, TSUYOSHI
AU - OPENSHAW, HARRY
AU - WOHLENBERG, CHARLES
AU - NOTKINS, ABNER LOUIS
T1 - Latency of Herpes Simplex Virus in Absence of Neutralizing Antibody: Model for Reactivation.
JO - Science
JF - Science
Y1 - 1980/11/28/
VL - 210
IS - 4473
M3 - Article
SP - 1026
EP - 1028
SN - 00368075
AB - Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266848; SEKIZAWA, TSUYOSHI 1; OPENSHAW, HARRY 1; WOHLENBERG, CHARLES 1; NOTKINS, ABNER LOUIS 1; Affiliations: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/28/1980, Vol. 210 Issue 4473, p1026; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Beebe, Gilbert W.
T1 - Record Linkage Systems--Canada vs the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/12//
VL - 70
IS - 12
M3 - Article
SP - 1246
EP - 1248
PB - American Public Health Association
SN - 00900036
AB - The article presents a comparison of linking national data systems that are being used by Canada and the U.S. to monitor health and to facilitate large-scale epidemiological studies of health hazards. Canada, as far as these systems are concerned, is making remarkable progress. The Canadian Mortality Data Base, tape file of all 4 million deaths in Canada for 1950-1977, and many other systems are powerful and economical tools for exploring genetic, environmental, and iatrogenic influences on health. The data resources of the U.S. Census Bureau , the Social Security Administration and many others has its own legal and administrative restrictions on access to its records.
KW - EPIDEMIOLOGY -- Research
KW - PUBLIC health -- Evaluation
KW - PUBLIC health administration
KW - PUBLIC health surveillance
KW - HEALTH risk assessment
KW - MORTALITY -- Statistics
KW - CANADA
KW - UNITED States
KW - UNITED States. Bureau of the Census
N1 - Accession Number: 4952311; Beebe, Gilbert W. 1; Affiliation: 1: Clinical Epidemiology Branch, National Cancer Institute, Rm 5A21 Landow Bldg., Bethesda, MD 20205.; Source Info: Dec1980, Vol. 70 Issue 12, p1246; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: PUBLIC health -- Evaluation; Subject Term: PUBLIC health administration; Subject Term: PUBLIC health surveillance; Subject Term: HEALTH risk assessment; Subject Term: MORTALITY -- Statistics; Subject Term: CANADA; Subject Term: UNITED States; Company/Entity: UNITED States. Bureau of the Census; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wesley McBride, O.
AU - Peterson, Jane L.
T1 - CHROMOSOME-MEDIATED GENE TRANSFER IN MAMMALIAN CELLS.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1980/12//
VL - 14
M3 - Article
SP - 321
EP - 345
PB - Annual Reviews Inc.
SN - 00664197
AB - Analyzes the process of chromosome-mediated gene transfer. Methods of chromosome transfer and transfer frequency; Uptake and expression of transgenome; Cytological detection of chromosome fragments.
KW - GENETIC transformation
KW - CHROMOSOMES
KW - TRANSGENES
KW - CYTOLOGY
N1 - Accession Number: 12409253; Wesley McBride, O. 1 Peterson, Jane L. 1; Affiliation: 1: Laboratory of Biochemistry, Division of Cancer Biology and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland; Source Info: 1980, Vol. 14, p321; Subject Term: GENETIC transformation; Subject Term: CHROMOSOMES; Subject Term: TRANSGENES; Subject Term: CYTOLOGY; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dourmashkin, R. R.
AU - Deteix, Patrice
AU - Simone, C. B.
AU - Henkart, P.
T1 - Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1980/12//
VL - 42
IS - 3
M3 - Article
SP - 554
EP - 560
PB - Wiley-Blackwell
SN - 00099104
AB - To test the hypothesis that complement-mediated cell lysis and cell -mediated cytotoxicity operate by analogous mechanisms. cell membranes from two antibody-dependent cytotoxicity systems were examined by electron microscopy alter negative staining. Ring- shaped membrane lesions generally similar to. but larger than, those previously described for complement lysis were observed. These findings are in agreement with recent measurements of larger functional pores for ADCC than complement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRON microscopy
KW - MICROSCOPY
KW - ELECTRON microscopic diagnosis
KW - CELL membranes
KW - BIOLOGICAL membranes
KW - BACTERIAL cell walls
N1 - Accession Number: 16443738; Dourmashkin, R. R. 1,2 Deteix, Patrice 3 Simone, C. B. 1,2 Henkart, P. 1,2; Affiliation: 1: Section of Electron Microscopy und Department of Cell Pathology, Clinical Research Centre, Harrow, UK. 2: Immunology Branch, National Cancer Institute National Institute of Health, Bethesda, Maryland, USA. 3: Hôpital E. Herriot, Clinique de Nephrologie, 69374 Lyon, Cedex 2, France.; Source Info: Dec1980, Vol. 42 Issue 3, p554; Subject Term: ELECTRON microscopy; Subject Term: MICROSCOPY; Subject Term: ELECTRON microscopic diagnosis; Subject Term: CELL membranes; Subject Term: BIOLOGICAL membranes; Subject Term: BACTERIAL cell walls; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JORDAN, ELKE
T1 - Nucleic Acid Sequences: Data Bank.
JO - Science
JF - Science
Y1 - 1980/12/05/
VL - 210
IS - 4474
M3 - Article
SP - 1074
EP - 1074
SN - 00368075
N1 - Accession Number: 85266858; JORDAN, ELKE 1; Affiliations: 1: Genetics Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1074; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAISER-KUPFER, MURIEL I.
AU - DE MONASTERIO, FRANCISCO M.
AU - VALLE, DAVID
AU - WALSER, MACKENSIE
AU - BRUSILOW, SAUL
T1 - Gyrate Atrophy of the Choroid and Retina: Improved Visual Function Following Reduction of Plasma Ornithine by Diet.
JO - Science
JF - Science
Y1 - 1980/12/05/
VL - 210
IS - 4474
M3 - Article
SP - 1128
EP - 1131
SN - 00368075
AB - In a patient with gyrate atrophy of the choroid and retina, an arginine-deficient diet has reduced plasma ornithine concentration fivefold during the past 20 months. Subjective improvement in her visual function was noted approximately 15 months after institution of her diet. This has been documented by improvements in the electroretinogram, dark-adaptation, and color vision. The improvement involves rod and, to a lesser extent, cone function. The results, although preliminary and limited to a single patient, suggest that reduction of plasma ornithine with a low arginine diet is beneficial in this disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266888; KAISER-KUPFER, MURIEL I. 1; DE MONASTERIO, FRANCISCO M. 1; VALLE, DAVID 2; WALSER, MACKENSIE 2; BRUSILOW, SAUL 2; Affiliations: 1: Clinical Branch, National Eye Institute, Bethesda, Maryland 20205; 2: Howard Hughes Medical Institute Laboratory and Departments of Pediatrics, Pharmacology and Experimental Therapeutics and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1128; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PIOMELLI, SERGIO
AU - CORASH, LAURENCE
AU - CORASH, MICHELE BEIGEL
AU - SEAMAN, CAROL
AU - MUSHAK, PAUL
AU - GLOVER, BARBARA
AU - PADGETT, RICHARD
T1 - Blood Lead Concentrations in a Remote Himalayan Population.
JO - Science
JF - Science
Y1 - 1980/12/05/
VL - 210
IS - 4474
M3 - Article
SP - 1135
EP - 1137
SN - 00368075
AB - The lead content in the air at the foothills of the Himalayas in Nepal was found to be negligible. The concentration of lead in the blood of 103 children and adults living in this region was found to average 3.4 micrograms per deciliter, a level substantially lower than that found in industrialized populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266891; PIOMELLI, SERGIO 1; CORASH, LAURENCE 2; CORASH, MICHELE BEIGEL 3; SEAMAN, CAROL 4; MUSHAK, PAUL 5; GLOVER, BARBARA 5; PADGETT, RICHARD 5; Affiliations: 1: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032; 2: Department of Clinical Pathology, National Institutes of Health, Bethesda, Maryland 20014; 3: Office of the General Counsel, Environmental Protection Agency, Washington, D.C. 20406; 4: Department of Pediatrics, Columbia University College of Physicians and Surgeons; 5: Department of Pathology, University of North Carolina School of Medicine, Chapel Hill 27514; Issue Info: 12/ 5/1980, Vol. 210 Issue 4474, p1135; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STETTEN JR., DEWITT
T1 - Eradication.
JO - Science
JF - Science
Y1 - 1980/12/12/
VL - 210
IS - 4475
M3 - Article
SP - 1203
EP - 1203
SN - 00368075
N1 - Accession Number: 85266905; STETTEN JR., DEWITT 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1203; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHANG, ESTHER H.
AU - ELLIS, RONALD W.
AU - SCOLNICK, EDWARD M.
AU - LOWY, DOUGLAS R.
T1 - Transformation by Cloned Harvey Murine Sarcoma Virus DNA: Efficiency Increased by Long Terminal Repeat DNA.
JO - Science
JF - Science
Y1 - 1980/12/12/
VL - 210
IS - 4475
M3 - Article
SP - 1249
EP - 1251
SN - 00368075
AB - The coding sequences for the transforming (src) protein (p21) of Harvey murine sarcoma virus have been localized to a 1.3 kilobase pair segment near the 5' end of the viral genome. Ligation of the viral terminal repeat DNA to the left end of the src region DNA markedly enhanced the low transforming efficiency of the src region DNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266926; CHANG, ESTHER H. 1; ELLIS, RONALD W. 1; SCOLNICK, EDWARD M. 1; LOWY, DOUGLAS R. 1; Affiliations: 1: Dermatology Branch and Tumor Virus Genetics Branch, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1249; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEWY, ALFRED J.
AU - WEHR, THOMAS A.
AU - GOODWIN, FREDERICK K.
AU - NEWSOME, DAVID A.
AU - MARKEY, S. P.
T1 - Light Suppresses Melatonm Secretion in Humans.
JO - Science
JF - Science
Y1 - 1980/12/12/
VL - 210
IS - 4475
M3 - Article
SP - 1267
EP - 1269
SN - 00368075
AB - Bright artificial light suppressed nocturnal secretion of melatonin in six normal human subjects. Room light of less intensity, which is sufficient to suppress melatonin secretion in other mammals, failed to do so in humans. In contrast to the results of previous experiments in which ordinary room light was used, these findings establish that the human response to light is qualitatively similar to that of other mammals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266933; LEWY, ALFRED J. 1; WEHR, THOMAS A. 1; GOODWIN, FREDERICK K. 1; NEWSOME, DAVID A. 2; MARKEY, S. P. 3; Affiliations: 1: Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1267; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SALLER, CHARLES F.
AU - CHIODO, LOIS A.
T1 - Glucose Suppresses Basal Firing and Haloperidol-Induced Increases in the Firing Rate of Central Dopaminergic Neurons.
JO - Science
JF - Science
Y1 - 1980/12/12/
VL - 210
IS - 4475
M3 - Article
SP - 1269
EP - 1271
SN - 00368075
AB - In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266934; SALLER, CHARLES F. 1; CHIODO, LOIS A. 2; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Psychobiology Program, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Issue Info: 12/12/1980, Vol. 210 Issue 4475, p1269; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-07141-000
AN - 9999-07141-000
AU - Glynn, Thomas J.
T1 - Community Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1981///
AD - Glynn, Thomas J., National Institute on Drug Abuse, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-07141-000. Other Names: Psychological Sense of Community Instrument. Partial author list: First Author & Affiliation: Glynn, Thomas J.; National Institute on Drug Abuse, Rockville, Maryland, United States. Release Date: 20111212. Correction Date: 20151207. Instrument Type: Inventory/Questionnaire. Test Format: items are rated on a 5-point Likert scale ranging from 'strongly agree' to 'strongly disagree.'. Language: English. Constructs: Psychological Sense of Community; Classification: Social, Group, and Interpersonal Relationships (7600). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Community Questionnaire is to measure the psychological sense of community.
AB - Description: The Community Questionnaire (Glynn, 1981) was developed to measure what Sarason (1974) termed as a 'psychological sense of community' (PSC)--a sense of belonging to one's community. Based on PSC behaviors and subconcepts identified in the literature review, a 14-stem sentence completion form was designed and administered to a sample of 37 respondents across 8 communities. For each PSC-related behavior or subconcept identified from each method, an attitude item directed at community-of-residence was developed. This resulted in 178 items that were assembled in a scale allowing the behavior or attitude to be rated. The instrument was designed to consist of 3 sections and take approximately 25 minutes to complete. The first part covers demographic data; the second part presents attitude and behavior statements rated on a scale; and the third part consists of several open-ended items tapping the subject's community participation, awareness, and competence. Items on Part II were selected from a judge's scale, with those in the lowest third of the t ratios being discarded. Then any remaining items rated as irrelevant by one-third or more of the judges was also discarded. This left 115 items. Those 60 items with the highest t ratios were then selected, with two exceptions. Each of the 60 selected items was then matched by the same item with the addition of the stem 'In an ideal community...' Subscales consisting of 8 competence items and 6 satisfaction items were added. Multiple regression analyses were performed using the criterion variables: Actual sense of community, Ideal sense of community, Community satisfaction, Community competence, and Difference between Actual and Ideal sense of community. Initial estimates of reliability of the measurements generated by the PSC instrument in 2 Maryland community samples and 1 Israeli community sample were made using Kuder-Richardson KR-20 estimates, resulting in estimates of .972 for the Actual scale and .924 for the Ideal scale. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Actual Community
KW - Community Questionnaire
KW - Community Satisfaction
KW - Gemeinschraft Relationships
KW - Ideal Community
KW - Psychological Sense of Community
KW - Psychometric Properties
U5 - Community Questionnaire [Test Development]Psychological sense of community: Measurement and application. (AN: 1982-04728-001 from PsycINFO) Glynn, Thomas J.; Sep, 1981. Source: Human Relations. 34(9), Sage Publications, US; Sep, 1981; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Respondents from Three Dissimilar Communities Aged 18 Years and Older; Location: United States and Israel Keywords: Actual Community; Community Questionnaire; Community Satisfaction; Gemeinschraft Relationships; Ideal Community; Psychological Sense of Community; Psychometric Properties; Subjects: Affiliation Motivation; Community Attitudes; Group Cohesion; Sense of Community; Social Integration; Social Psychology; Test Reliability; Test Validity;
DO - 10.1037/t07141-000
L3 - Full; Full text; 999907141_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Brody, Jacob A.
T1 - Manning the Battlements of Research and Epidemiology.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/01//
VL - 71
IS - 1
M3 - Article
SP - 70
EP - 72
PB - American Public Health Association
SN - 00900036
AB - International trends and recently proposed changes risk confining the duties of epidemiologists to support of health services delivery or to serving as functionaries within exclusively clinical departments pose a threat to the future role and training of epidemiologists. It is argued that these attempts would weaken the academic focus for epidemiologists and compromise the system of recognition and rewards available through the hierarchy of the discipline. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGISTS
KW - PUBLIC health personnel
KW - PUBLIC health
KW - MEDICAL care
KW - HEALTH education
KW - MEDICAL ethics
KW - HEALTH promotion
KW - MEDICAL personnel -- Training of
KW - UNITED States
N1 - Accession Number: 4945665; Brody, Jacob A. 1; Affiliation: 1: Associate Director for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, 7550 Wisconsin Avenue, Bethesda, MD 20205.; Source Info: Jan1981, Vol. 71 Issue 1, p70; Subject Term: EPIDEMIOLOGISTS; Subject Term: PUBLIC health personnel; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: HEALTH education; Subject Term: MEDICAL ethics; Subject Term: HEALTH promotion; Subject Term: MEDICAL personnel -- Training of; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaros, Daniel B.
T1 - RADIATION BIOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1981/01//
VL - 31
IS - 1
M3 - Book Review
SP - 70
EP - 70
SN - 00063568
AB - The article reviews the book "Biological Effects of Ultraviolet Radiation," by Walter Harm.
KW - Ultraviolet radiation -- Physiological effect
KW - Nonfiction
KW - Harm, Walter
KW - Biological Effects of Ultraviolet Radiation (Book)
N1 - Accession Number: 28051066; Yaros, Daniel B. 1; Affiliations: 1 : Building 37, Room 3d National Institutes of Health Bethesda, MD 2001; Source Info: Jan1981, Vol. 31 Issue 1, p70; Subject Term: Ultraviolet radiation -- Physiological effect; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 708
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Barrett, Susanna F.
AU - Tarone, Robert E.
AU - Moshell, Alan N.
AU - Ganges, Mary B.
AU - Robbins, Jay H.
T1 - The Post-UV Colony-Forming Ability of Normal Fibroblast Strains and of the Xeroderma Pigmentosum Group G Strain.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/01//
VL - 76
IS - 1
M3 - Article
SP - 59
EP - 62
SN - 0022202X
AB - In xeroderma pigmentosum, an inherited disorder of defective DNA repair, post-UV colony-forming ability of fibroblasts from patients in complementation groups A through F correlates with the patients neurological status. The first xeroderma pigmentosum patient assigned to the recently discovered group G had the neurological abnormalities of XP. We have determined the post-UV colony-forming ability of cultured fibroblasts from this patient and from 5 more control donors. Log-phase fibroblasts were irradiated with 254 no UV light from a germicidal lamp, trypsinized, and replated at known densities. After 2 to 4 weeks incubation the cells were fixed, stained and scored for colony formation. The strains post-UV colony-forming ability curves were obtained by plotting the log of the percent remaining post- UV colony-forming ability as a function of the UV dose. The post-UV colony-forming ability of 2 of the 5 new normal strains was in the previously defined control donor zone, but that of the other 3 extended down to the level of the most resistant xeroderma pigmentosum strain. The post-UV colony-forming ability curve of the group G fibroblasts was not significantly different from the curves of the group D fibroblast strains from patients with clinical histories similar to that of the group G patient. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - XERODERMA pigmentosum
KW - GENETIC disorders
KW - DNA repair
KW - NEUROLOGY
KW - IRRADIATION
N1 - Accession Number: 12524886; Barrett, Susanna F. 1 Tarone, Robert E. 1 Moshell, Alan N. 1 Ganges, Mary B. 1 Robbins, Jay H. 1; Affiliation: 1: Dermatology and Biometry Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1981, Vol. 76 Issue 1, p59; Subject Term: FIBROBLASTS; Subject Term: XERODERMA pigmentosum; Subject Term: GENETIC disorders; Subject Term: DNA repair; Subject Term: NEUROLOGY; Subject Term: IRRADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12524886
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-11819-001
AN - 2009-11819-001
AU - Parloff, Morris B.
T1 - An extraordinary life.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1981///
VL - 7
IS - 3
SP - 383
EP - 384
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Parloff, Morris B., Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US, 20857
N1 - Accession Number: 2009-11819-001. Partial author list: First Author & Affiliation: Parloff, Morris B.; Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Obituary. Language: English. Major Descriptor: Psychologists. Minor Descriptor: Scientific Communication. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Page Count: 2. Issue Publication Date: 1981.
AB - Remembers David Shakow, Scientist Emeritus of the National Institute of Mental Health and a founding member of the Schizophrenia Bulletin's Editorial Advisory Board. The author speaks of his personal experiences with Shakow, and celebrates his good fortune in having been some small part of it for nearly three decades. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - David Shakow
KW - psychologist
KW - personal experiences
KW - 1981
KW - Psychologists
KW - Scientific Communication
KW - 1981
DO - 10.1093/schbul/7.3.383
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - MAXFIELD, F. R.
AU - WILLINGHAM, M. C.
AU - PASTAN, I.
AU - DRAGSTEN, P.
AU - CHENG, S.-Y.
T1 - Binding and Mobility of the Cell Surface Receptors for 3,3',5-Triiodo-L-Thyronine.
JO - Science
JF - Science
Y1 - 1981/01/02/
VL - 211
IS - 4477
M3 - Article
SP - 63
EP - 65
SN - 00368075
AB - A fluorescent derivative of the thyroid hormone 3,3',5-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85267008; MAXFIELD, F. R. 1; WILLINGHAM, M. C. 1; PASTAN, I. 1; DRAGSTEN, P. 2; CHENG, S.-Y. 3; Affiliations: 1: National Cancer Institute, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Theoretical Biology, National Cancer Institute; 3: Clinical Endocrinology Branch, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health; Issue Info: 1/ 2/1981, Vol. 211 Issue 4477, p63; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Atlas, Daphne
AU - Sabol, Steven L.
T1 - Interaction of Clonidine and Clonidine Analogues with α-Adrenergic Receptors of Neuroblastoma × Glioma Hybrid Cells and Rat Brain.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/01/15/
VL - 113
IS - 3
M3 - Article
SP - 521
EP - 529
PB - Wiley-Blackwell
SN - 00142956
AB - Clonidine and several analogues of clonidine are shown to be useful probes for α2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase. The α-adrenergic properties of a new potential probe, N-(4-hydroxyphenacetyl)-4-aminoclonidine hydrochloride, are described. [³H]Clonidine binds to s-receptors of NG108-15 neuroblastoma × glioma hybrid cell membranes with Kd values of 1.7 and 33 nM for putative high-affinity and low-affinity sites, respectively, p-Aminoclonidine and hydroxyphenacetyl aminocionidine displace [³H]clonidine from the high-affinity sites with Kd values of 2.3 and 5.8 nM, respectively. Rat brain α2-receptors also exhibit high affinity toward clonidine, p-aminoclonidine, and hydroxyphenacetyl aminoclonidine, as determined by displacement of specifically bound [³H]clonidine. Clonidine, p-aminoclonidine, and hydroxyphenacetyl aminocionidine elicit modest inhibition (up to 24%) of NG108-15 adenylate cyclase by interaction with α2-receptors (Kd,app 300, 50, and 130 nM, respectively); these compounds also partially reverse the inhibition elicited by (-)-norepinephrine. Components of the adenylate cyclase assay mixture, particularly ATP, GTP, sodium ions, and a nucleoside-triphosphate-regenerating system, decrease the high-affinity [³H]clonidine binding to NG108-15 membranes; in the presence of these components, α-receptors possess only low affinity (Kd 43 nM) for [³H]clonidine. These results are consistent with the concept that certain components required for the receptor-mediated inhibition of adenylate cyclase convert α2-receptors from a highaffinity inactive state to a low-affinity active state. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLONIDINE
KW - ALPHA adrenoceptors
KW - NEUROBLASTOMA
KW - GLIOMAS
KW - LIGAND binding (Biochemistry)
KW - ADENYLATE cyclase
KW - INHIBITORS
N1 - Accession Number: 11227619; Atlas, Daphne 1 Sabol, Steven L. 1; Affiliation: 1: Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute and Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Disease, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/81, Vol. 113 Issue 3, p521; Subject Term: CLONIDINE; Subject Term: ALPHA adrenoceptors; Subject Term: NEUROBLASTOMA; Subject Term: GLIOMAS; Subject Term: LIGAND binding (Biochemistry); Subject Term: ADENYLATE cyclase; Subject Term: INHIBITORS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - FERGUSON, H. BRUCE
AU - RAPOPORT, JUDITH L.
AU - WEINGARTNER, HERBERT
AU - SWANSON, JAMES M.
AU - KINSBOURNE, MARCEL
T1 - Food Dyes and Impairment of Performance in Hyperactive Children.
JO - Science
JF - Science
Y1 - 1981/01/23/
VL - 211
IS - 4480
M3 - Article
SP - 410
EP - 411
SN - 00368075
N1 - Accession Number: 85267124; FERGUSON, H. BRUCE 1; RAPOPORT, JUDITH L. 2; WEINGARTNER, HERBERT 3; SWANSON, JAMES M. 4,5; KINSBOURNE, MARCEL 6; Affiliations: 1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Unit on Childhood Mental Illness, National Institute of Mental Health; 3: Laboratory of Psychology and Psychopathology, National Institute of Mental Health; 4: Fairview State Hospital, Costa Mesa, California 92626; 5: Hospital for Sick Children, Toronto, Ontario, Canada M5S IA8; 6: Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts 02254; Issue Info: 1/23/1981, Vol. 211 Issue 4480, p410; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WALLACE, GORDON D.
T1 - Mouse Pox Threat.
JO - Science
JF - Science
Y1 - 1981/01/30/
VL - 211
IS - 4481
M3 - Article
SP - 438
EP - 438
SN - 00368075
N1 - Accession Number: 85196761; WALLACE, GORDON D. 1,2; Affiliations: 1: Office, Scientific Director, National Institute of Allergy; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/30/1981, Vol. 211 Issue 4481, p438; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Riley, Matilda White
T1 - HOW OLD IS AGE 75?
JO - American Sociologist
JF - American Sociologist
Y1 - 1981/02//
VL - 16
IS - 1
M3 - Article
SP - 38
EP - 40
SN - 00031232
AB - This article reflects on the progress of the American Sociological Association (ASA) from 1905 to 1980. The author relates that when she took office elate in 1949, there were approximately 2,700 members on the Society's roles. Ten years later there were 7,000. With the Reorganization Committee of 1950 anticipating the potential, certain goals for the Association were set early in the decade. There were eight goals that the society was determined to accomplish. It is a matter of record that considerable progress was made during the decade of the 1950s in moving toward these goals especially the first six Constitutional changes were affected. membership participation was broadened. An executive office was organized. Several new publications were started. Membership services generally were expanded. All the annual meeting, over 300 papers were presented in 1960 in contrast to 77 in 1950. In two important respects, however, the mid-century ASA was somewhat less effective in performing its supportive role in expanding the uses of sociology and in aiding the development of the discipline. For example, responding to indications that sociologists were needed in a variety of practicing professions, ASA together with Russell Sage Foundation, undertook a series of bulletins on the fields of sociological application.
KW - ASSOCIATIONS, institutions, etc.
KW - SOCIOLOGY -- United States
KW - SOCIOLOGY
KW - MEMBERSHIP
KW - SOCIOLOGISTS
KW - PROFESSIONS
KW - CHARITABLE uses, trusts, & foundations (Law)
KW - UNITED States
KW - AMERICAN Sociological Association
N1 - Accession Number: 4944948; Riley, Matilda White 1; Affiliation: 1: Bowdoin College and National Institute on Aging; Source Info: Feb81, Vol. 16 Issue 1, p38; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: SOCIOLOGY -- United States; Subject Term: SOCIOLOGY; Subject Term: MEMBERSHIP; Subject Term: SOCIOLOGISTS; Subject Term: PROFESSIONS; Subject Term: CHARITABLE uses, trusts, & foundations (Law); Subject Term: UNITED States; Company/Entity: AMERICAN Sociological Association DUNS Number: 074801341; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 813211 Grantmaking Foundations; NAICS/Industry Codes: 813319 Other Social Advocacy Organizations; NAICS/Industry Codes: 813920 Professional Organizations; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pandolfl, F.
AU - Strong, D. M.
AU - Slease, R. B.
AU - Bonnard, G. D.
T1 - Serological and functional characterization of human T cell subsets.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/02//
VL - 43
IS - 2
M3 - Article
SP - 319
EP - 328
PB - Wiley-Blackwell
SN - 00099104
AB - Two different specific anti-human T cell sera were studied. One was raised against fetal thymocytes (anti-HTY) and the other against human cultured T cells (anti-CTC) grown in the presence of conditioned medium from phytohaemagglutinin-stimulated peripheral blood mononuclear leucocytes (PBL). These sera, after various absorptions, reacted in microcytotoxicity assays against T cells, but not with B and null cells in the peripheral blood of both normal donors and patients with non-T leukaemias. A clear distinction between the labelling density of T versus B cells was also documented with the fluorescence- activated cell-sorter (FACS) analyses. These two sera were further absorbed on T cells from different sources with the aim of obtaining reagents specific for T cell subsets. Two reagents resulting from these absorptions were found to react with subsets of T-PBL. (1) Anti-HTY, after absorption with cells of a T-chronic lymphocyte leukaemia (T-CLL) expressing receptors for the Fc portion of IgG, reacted with thymocytes, 40-50% of normal T-PBL and only with those T cells that were not inhibited by theophylline in their ability to rosette with sheep erythrocytes. When PBL were preincubated with the absorbed serum and complement, the remaining cells had markedly diminished lymphoproliferative responses to lectins and in mixed lymphocyte culture (MLC), but they still responded well to tetanus toxoid (t.tox.). (2) Anti-CTC, after absorption with the MOLT-4 cell line reacted with about 30%, of T-PBL and with the majority of the T-CLL cells with Fc receptors, as documented by cytotoxicity and FACS analyses. When normal PBL were preincubated with this absorbed serum and complement, the remaining cells had enhanced lymphoproliferative responses to lectins and especially to t.tox. and in MLC. Thus, these antisera, obtained following some rather simple absorption steps, were able to divide human T cells into two major and distinct subpopulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ABSORPTION
KW - LYMPHOCYTES
KW - T cells
KW - SERUM
KW - BLOOD plasma
KW - BLOOD cells
N1 - Accession Number: 16012019; Pandolfl, F. 1 Strong, D. M. 2,3 Slease, R. B. 2,3 Bonnard, G. D. 2,3; Affiliation: 1: Division of Infectious Disease II, Institute of Internal Medicine III, University of Rome, Italy. 2: Laboratory of Immunodiagnosis, National Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, USA. 3: Transplantation Research Branch, Naval Medical Research Institute, Bethesda, Maryland, USA.; Source Info: Feb1981, Vol. 43 Issue 2, p319; Subject Term: ABSORPTION; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: BLOOD cells; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraemer, Kenneth H.
AU - Waters, Haywood L.
AU - Cohen, Lawrence F.
AU - Popescu, Nicolae C.
AU - Amsbaugh, Suzanne C.
AU - DiPaolo, Joseph A.
AU - Glaubiger, Daniel
AU - Ellingson, Owen L.
AU - Tarone, Robert E.
T1 - Effects of 8-Methoxypsoralen and Ultraviolet Radiation on Human Lymphoid Cells in Vitro.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/02//
VL - 76
IS - 2
M3 - Article
SP - 80
EP - 87
SN - 0022202X
AB - Oral 8-methoxypsoralen (8-MOP) plus high-intensity long-wavelength ultraviolet radiation (UV-A) is used clinically to induce remissions of psoriasis and mycosis fungoides, Leukocytes in 8-MOP containing blood receive UV-A exposure when circulating through the dermis during therapy. The present study utilizes an in vitro assay system to permit quantitation and correlation of multiple biological and physical alterations in human lymphoid cells induced by 8-MOP plus UV-A treatment. Additive inhibition of lymphoid cell DNA synthesis by 8-MOP (0.01 to 1 μg/ml) plus UV-A (1,000 to 29,000 J/m²) was accompanied by a synergistic potentiation of cell killing in the therapeutic exposure range. Reduction in tritiated thymidine (³HTdR) incorporation to 65-70% of control value was associated with normal survival; while ³HTdR incorporation of less than 50% of control induced by any 8-MOP plus UV-A combination tested was associated with less than 10% survival, 8-MOP-DNA-cross-links were detected by the alkaline elution assay only when ³HTdR incorporation was reduced to less than 50% of control. The relative number of crosslinks increased proportionately with further 8-MOP plus UV-A-induced reduction in ³HTdR incorporation. 8-MOP plus UV-A induced at most approximately a 2-fold increase in sister chromatid exchanges (SCE) per chromosome in lymphocytes or lymphoblastoid cells, Increasing 8-MOP plus UV-A exposure resulted in marked toxicity with few cells progressing to second division metaphases and no further increase in SCE's per chromosome, Addition of 13-cis retinoic acid (1μg/ml) to the lymphoblastoid cells prior to 8-MOP plus UV-A treatment did not significantly alter the ³HTdR incorporation or cell survival. These studies dermonstrate that in vitro exposure of human lymphoid cells to therapeutic levels of 8-MOP and UV-A may decrease cellular DNA synthesis, produce DNA 8-MOP interstrand cross-links, reduce cell viability and induce small increases in sister chromosome exchanges. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - ULTRAVIOLET radiation
KW - LEUCOCYTES
KW - DNA
KW - MYCOSIS fungoides
KW - LYMPHOPROLIFERATIVE disorders
N1 - Accession Number: 12525352; Kraemer, Kenneth H. 1 Waters, Haywood L. 1 Cohen, Lawrence F. 2 Popescu, Nicolae C. 3 Amsbaugh, Suzanne C. 3 DiPaolo, Joseph A. 3 Glaubiger, Daniel 2 Ellingson, Owen L. 4 Tarone, Robert E. 5; Affiliation: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland. 2: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. 3: Laboratory of Biology, National Cancer Institute, Bethesda, Maryland. 4: Electrooptics Branch, Division of Electronic Products, Bureau of Radiologic Health, Food and Drug Administration, Rockville, Maryland, U.S.A. 5: Biometry Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Feb81, Vol. 76 Issue 2, p80; Subject Term: LYMPHOID tissue; Subject Term: ULTRAVIOLET radiation; Subject Term: LEUCOCYTES; Subject Term: DNA; Subject Term: MYCOSIS fungoides; Subject Term: LYMPHOPROLIFERATIVE disorders; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525352
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hintner, H.
AU - Stingl, G.
AU - Schuler, G.
AU - Fritsch, P.
AU - Stanley, J.
AU - Katz, S.
AU - Wolff, K.
T1 - Immunofluorescence Mapping of Antigenic Determinants within the Dermal-epidermal Junction in Mechanobullous Diseases.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/02//
VL - 76
IS - 2
M3 - Article
SP - 113
EP - 118
SN - 0022202X
AB - The classification of mechanobullous diseases often depends on the electron microscopic distinction of intradermal (dermolytic), junctional and intraepidermal sites of cleavage. Electron microscopy is tedious and time consuming. In this report we describe a different approach to the determination of the cleavage plane by using a method which recognizes subtle differences in the localization of antigenic structures relative to the cleavage plane. Cryostat sections of lesional and extralesional skin of 3 patients with dermolytic epidermolysis bullosa, 3 with epidermolytic epidermolysis bullosa and 8 with junctional epidermolysis bullosa were examined by immunofluorescence, with specific antisera against type IV collagen (localized within the basal lamina); against laminin (noncollagenous protein, localized in the lamina lucida); and with bullous pemphigoid antibodies (directed against the bullous pemphigoid antigen localized in the lamina lucida). All specimens were also examined by electron microscopy. In dermolytic epidermolysis bullosa (where cleft formation occurs intradermally) type IV collagen, laminin and the bullous pemphigoid antigen were consistently found in the roof of the blister, whereas in junctional epidermolysis bullosa (where the cleft occurs in the lamina lucida) type IV collagen and laminin were found on the floor of the blister whereas bullous pemphigold antigen was present mainly on the roof but focally also on the floor, of the blister. In epidermolytic epidermolysis bullosa (where the cleft is intraepidermal) all antigens were localized below the cleavage plane. In all cases electron microscopy confirmed the level of cleft formation predicted from the immunofluorescence mapping of the antigenic sites. The described method equals electron microscopy in accuracy but it is more rapid and simpler to perform. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOFLUORESCENCE
KW - ANTIGENIC determinants
KW - ELECTRON microscopy
KW - INTRADERMAL injections
KW - CRYOTOMY
KW - EPIDERMOLYSIS bullosa
KW - IMMUNE serums
N1 - Accession Number: 12525447; Hintner, H. 1 Stingl, G. 1 Schuler, G. 1 Fritsch, P. 1 Stanley, J. 2 Katz, S. 2 Wolff, K. 1; Affiliation: 1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 2: Department of Dermatology Branch, National Cancer Institute and Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb81, Vol. 76 Issue 2, p113; Subject Term: IMMUNOFLUORESCENCE; Subject Term: ANTIGENIC determinants; Subject Term: ELECTRON microscopy; Subject Term: INTRADERMAL injections; Subject Term: CRYOTOMY; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: IMMUNE serums; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525447
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuspa, Stuart H.
AU - Koehler, Barbara
AU - Kulesz-Martin, Molly
AU - Hennings, Henry
T1 - Clonal Growth of Mouse Epidermal Cells in Medium with Reduced Calcium Concentration.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/02//
VL - 76
IS - 2
M3 - Article
SP - 144
EP - 146
SN - 0022202X
AB - Mouse keratinocytes can he grown at clonal densities in dermal fibroblast conditioned medium with a calcium concentration of 0.02 MM. Colony forming efficiencies of approximately 1-3% can be achieved with primary and secondary cultures and up to 6% with selected subclones. A substrate of frozen-thawed dermal fibroblasts enhances colony formation over plastic. Colony size increases more rapidly in the presence of epidermal growth factor in conditioned medium, Conditioning of medium by fibroblasts is optimum after day 6 of culture and conditioned medium can be stored at -20°C for at least 4 mo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATINOCYTES
KW - FIBROBLASTS
KW - CYTOKINES
KW - COLONIES (Biology)
KW - GROWTH factors
KW - CLONE cells
N1 - Accession Number: 12525490; Yuspa, Stuart H. 1 Koehler, Barbara 1 Kulesz-Martin, Molly 1 Hennings, Henry 1; Affiliation: 1: In Vitro Pathogenesis Section, Laboratory of Experimental Pathology National Cancer, Institute, Bethesda, Maryland, U.S.A.; Source Info: Feb81, Vol. 76 Issue 2, p144; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: CYTOKINES; Subject Term: COLONIES (Biology); Subject Term: GROWTH factors; Subject Term: CLONE cells; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525490
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06553-058
AN - 2006-06553-058
AU - Riley, Matilda White
T1 - Adult Development.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1981/02//
VL - 26
IS - 2
SP - 144
EP - 145
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06553-058. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Riley, Matilda White; National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adult Development; Developmental Stages; Psychodynamics; Sociocultural Factors. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Smelser, Neil J. (Ed); Erikson, Erik H. (Ed). Themes of Work and Love in Adulthood=Cambridge, Mass.: Harvard University Press, 1980 x + 297 pp $15 00; 1980. Page Count: 2. Issue Publication Date: Feb, 1981.
AB - Reviews the book, Themes of Work and Love in Adulthood edited by Neil J. Smelser and Erik H. Erikson (1980). Among the many recent works on adult development, this book is important because of its implicit emphasis on the gap between psychodynamic and sociocultural understandings. Despite the usual difficulties of interdisciplinary communication, one can discern in the chapters of the book numerous attempts to link subjective developmental processes and sociocultural contexts. Through its concentration on psychodynamic and sociocultural approaches, the book falls short of its plan to reflect the current state of research and thinking on adult development. Yet, it is the difficulties and shortcomings of the book that lay bare its unique contribution. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work
KW - love
KW - adulthood
KW - adult development
KW - psychodynamic
KW - sociocultural understandings
KW - developmental processes
KW - 1981
KW - Adult Development
KW - Developmental Stages
KW - Psychodynamics
KW - Sociocultural Factors
KW - 1981
U2 - Smelser, Neil J. (Ed); Erikson, Erik H. (Ed). (1980); Themes of Work and Love in Adulthood; Cambridge, Mass.: Harvard University Press, 1980 x + 297 pp $15 00
DO - 10.1037/019968
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - GREGG, RICHARD E.
AU - ZECH, LOREN A.
AU - SCHAEFER, ERNST J.
AU - BREWER JR., H. BRYAN
T1 - Type III Hyperlipoproteinemia: Defective Metabolism of an Abnormal Apolipoprotein E.
JO - Science
JF - Science
Y1 - 1981/02/06/
VL - 211
IS - 4482
M3 - Article
SP - 584
EP - 586
SN - 00368075
AB - The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein Efrom normal subjects, apolipoprotein E isolated from subjects wtith type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948100; GREGG, RICHARD E. 1; ZECH, LOREN A. 1; SCHAEFER, ERNST J. 1; BREWER JR., H. BRYAN 1; Affiliations: 1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p584; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KEETON, T. KENT
AU - KRUTZSCH, HENRY
AU - LOVENBERG, WALTER
T1 - Specific and Sensitive Radioimmunoassay for 3-Methoxy-4-hydroxyphenylethyleneglycol (MOPEG).
JO - Science
JF - Science
Y1 - 1981/02/06/
VL - 211
IS - 4482
M3 - Article
SP - 586
EP - 588
SN - 00368075
AB - Antibodies that specifically bind the norepinephrine metabolite 3-methoxy- 4-hydroxyphenylethyleneglycol (MOPEG) were produced in rabbits after injection of a derivative of MOPEG conjugated with bovine thyroglobulin. A sensitive radioimmunoassay was devised with this antiserum, in which as little as 0.5 nanogram of MOPEG can be accurately measured with afinal antibody dilution of 1:180. The antibody appears to be specific for MOPEG, since tritiated MOPEG was not displacedfrom the antibodies by norepinephrine, epinephrine, dopamine, serotonin, or their major metabolites, including MOPEG-sulfate (333 nanograms each). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948101; KEETON, T. KENT 1; KRUTZSCH, HENRY 2; LOVENBERG, WALTER 3; Affiliations: 1: Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284; 2: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 3: Section on Biochemical Pharmacology, National Heart, Lung, and Blood Institute; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p586; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINGARTNER, HERBERT
AU - GOLD, PHILIP
AU - BALLENGER, JAMES C.
AU - SMALLBERG, SHEILA A.
AU - SUMMERS, RICHARD
AU - RUBINOW, DAVID R.
AU - POST, ROBERT M.
AU - GOODWIN, FREDERICK K.
T1 - Effects of Vasopressin on Human Memory Functions.
JO - Science
JF - Science
Y1 - 1981/02/06/
VL - 211
IS - 4482
M3 - Article
SP - 601
EP - 603
SN - 00368075
AB - Arginine vasopressin and a number of its synthetic analogs augment memory functions in experimental animals. One of these analogs, 1-desamino-8-Darginine vasopressin (DDAVP), influences human learning and memory. Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVPfor a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency (reliability) of recall. DDAVP also appears to reverse partially the retrograde amnesia that follows electroconvulsive treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948108; WEINGARTNER, HERBERT 1; GOLD, PHILIP 1; BALLENGER, JAMES C. 1; SMALLBERG, SHEILA A. 1; SUMMERS, RICHARD 1; RUBINOW, DAVID R. 1; POST, ROBERT M. 1; GOODWIN, FREDERICK K. 1; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/ 6/1981, Vol. 211 Issue 4482, p601; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kalberer Jr., John T.
T1 - Grant Length and Budget Stability at the National Institutes of Health.
JO - Science
JF - Science
Y1 - 1981/02/13/
VL - 211
IS - 4483
M3 - Article
SP - 675
EP - 680
SN - 00368075
N1 - Accession Number: 88003186; Kalberer Jr., John T. 1; Affiliations: 1: Assistant director, Office for Medical Applications of Research, Office of the Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p675; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CRAWLEY, JACQUELINE N.
AU - MARANGOS, PAUL J.
AU - PAUL, STEVEN M.
AU - SKOLNICK, PHIL
AU - GOODWIN, FREDERICK K.
T1 - Interaction Between Purine and Benzodiazepine: Inosine Reverses Diazepam-Induced Stimulation of Mouse Exploratory Behavior.
JO - Science
JF - Science
Y1 - 1981/02/13/
VL - 211
IS - 4483
M3 - Article
SP - 725
EP - 727
SN - 00368075
AB - Inosine, 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam. The inhibition of exploratory behavior by purines occurred at doses that when given alone have no effect on exploratory behavior. 7-Methylinosine, which does not bind to the brain benzodiazepine binding site in vitro, had no effect on the diazepam-induced increase in exploratory behavior. Behavioral effects produced by various combinations of inosine and diazepam indicate that the interaction between purine and benzodiazepine is antagonistic and support the hypothesis that the naturally occurring purinesfunction in anxiety-related behaviors that respond to benzodiazepine treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003215; CRAWLEY, JACQUELINE N. 1; MARANGOS, PAUL J. 1; PAUL, STEVEN M. 1; SKOLNICK, PHIL 2; GOODWIN, FREDERICK K. 3; Affiliations: 1: Clinical Psychology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bio-Organic Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20205; 3: Clinical Psychology Branch, National Institute of Mental Health; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p725; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DEUTSCH, J. A.
AU - FREED, WILLIAM J.
AU - BING, LLOYD A.
AU - WYATT, RICHARD JED
T1 - Calcitonin: Aversive Effects in Rats?
JO - Science
JF - Science
Y1 - 1981/02/13/
VL - 211
IS - 4483
M3 - Article
SP - 733
EP - 734
SN - 00368075
N1 - Accession Number: 88003220; DEUTSCH, J. A. 1; FREED, WILLIAM J. 2; BING, LLOYD A. 2; WYATT, RICHARD JED 2; Affiliations: 1: Department of Psychology, University of California, San Diego, La Jolla 92093; 2: Adult Psychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/13/1981, Vol. 211 Issue 4483, p733; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - Guranowski, Andrzej B.
AU - Chiang, Peter K.
AU - Cantoni, Giulio L.
T1 - 5'-Methylthioadenosine Nucleosidase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/02/16/
VL - 114
IS - 2
M3 - Article
SP - 293
EP - 299
PB - Wiley-Blackwell
SN - 00142956
AB - Characterizes the enzyme 5'-methylthioadenosine nucleosidase from the seeds of Lupinus luteus. Enzyme purification; Molecular weight; Synthetic analogs; Enzyme substrate specificity; Substitute substrates; Enzyme deamination.
KW - NUCLEOSIDASES
KW - PLANT enzymes
KW - SEEDS
KW - LUPINUS luteus
KW - MOLECULAR weights
KW - DEAMINATION
N1 - Accession Number: 12176818; Guranowski, Andrzej B. 1 Chiang, Peter K. 1 Cantoni, Giulio L. 1; Affiliation: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda; Source Info: 2/16/81, Vol. 114 Issue 2, p293; Subject Term: NUCLEOSIDASES; Subject Term: PLANT enzymes; Subject Term: SEEDS; Subject Term: LUPINUS luteus; Subject Term: MOLECULAR weights; Subject Term: DEAMINATION; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; NAICS/Industry Codes: 418320 Seed merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - LAKE, C. R.
AU - GULLNER, H. G.
AU - POLINSKY, R. J.
AU - EBERT, M. H.
AU - ZIEGLER, M. G.
AU - BARTTER, F. C.
T1 - Essential Hypertension: Central and Peripheral Norepinephrine.
JO - Science
JF - Science
Y1 - 1981/02/27/
VL - 211
IS - 4485
M3 - Article
SP - 955
EP - 957
SN - 00368075
AB - The concentration of norepinephrine in cerebrospinalfluidfrom patients with essential hypertension is higher than that from healthy normal volunteers, but the concentrations of norepinephrine in plasma from these groups are similar. This finding indicates that central nervous system noradrenergic hyperactivity occurs in essential hypertension but apparently is not reflected in abnormal function of the peripheral sympathetic nervous system in these patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948157; LAKE, C. R. 1; GULLNER, H. G. 2; POLINSKY, R. J. 3; EBERT, M. H. 3; ZIEGLER, M. G. 4; BARTTER, F. C. 5; Affiliations: 1: Departments of Psychiatry and Pharmacology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland 20014; 2: National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 3: Section of Experimental Therapeutics, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Department of Medicine, University of San Diego, La Jolla, California 92037; 5: Audie Murphy Veterans Administration Hospital, San Antonio, Texas 78284; Issue Info: 2/27/1981, Vol. 211 Issue 4485, p955; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Lawrence, E. C.
AU - Arnaud-Battandier, F.
AU - Grayson, Jane
AU - Koski, Irma R.
AU - Dooley, Nancy J.
AU - Muchmore, A. V.
AU - Blaese, R. M.
T1 - Ontogeny of humoral immune function in normal chickens: a comparison of immunoglobulin-secreting cells in bone marrow, spleen, lungs and intestine.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/03//
VL - 43
IS - 3
M3 - Article
SP - 450
EP - 457
PB - Wiley-Blackwell
SN - 00099104
AB - A reverse haemolytic plaque assay was employed to study the ontogeny of immunoglobulin (Ig) secreting cells of either IgG, IgA, or IgM class in normal chickens. After hatching, IgM-secreting cells were detectable in the spleen by 3 days of age whereas IgG- and lgA-secreting cells were first noted at 6 days. Adult Levels of Ig-secreting cells of all three classes were attained by 31 days of age in bone marrow and two separate lymphoid populations (lamina propria and intraepithelial lymphocytes). By contrast, adult levels of Ig-secreting cells were not obtained in either the spleen or the lungs until after 50 days of age. In the case of the spleen, the delay in attainment of adult levels of total Ig-secreting cells reflected the smaller spleen size in immature birds, whereas the percentages of cells secreting Ig of each class were in the adult range by 31 days. By contrast, the numbers of cells recovered from the lungs of 50-day-old chickens were near the adult range, while the percentages of cells secreting either IgG, IgA, or IgM were much fewer than those seen in the lungs of adult chickens. These data indicate that the lungs of normal chickens are populated more slowly with Ig-secreting cells than either the bone marrow, spleen, or intestine. At all ages studied, greater numbers of Pg-secreting cells, particularly of the IgG and IgM classes, were recovered from the bone marrow and spleen as compared to the lungs and intestine. Since only a portion of the total bone marrow population was studied, these data indicate that the bone marrow may be a major site of Ig-secreting cells in chickens beginning shortly after hatching. [ABSTRACT FROM AUTHOR]
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KW - IMMUNOGLOBULINS
KW - ONTOGENY
KW - LYMPHOID tissue
KW - LYMPHOCYTIC leukemia
KW - LYMPHOCYTES
KW - BONE marrow cells
KW - HEMOLYSIS & hemolysins
KW - CHICKENS as laboratory animals
N1 - Accession Number: 16242787; Lawrence, E. C. 1 Arnaud-Battandier, F. 1 Grayson, Jane 1 Koski, Irma R. 1 Dooley, Nancy J. 1 Muchmore, A. V. 1 Blaese, R. M. 2; Affiliation: 1: Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2: Department of Internal Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA.; Source Info: Mar1981, Vol. 43 Issue 3, p450; Subject Term: IMMUNOGLOBULINS; Subject Term: ONTOGENY; Subject Term: LYMPHOID tissue; Subject Term: LYMPHOCYTIC leukemia; Subject Term: LYMPHOCYTES; Subject Term: BONE marrow cells; Subject Term: HEMOLYSIS & hemolysins; Subject Term: CHICKENS as laboratory animals; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gregory, S. H.
AU - Kern, M.
T1 - Mitogenic response to T-cell subclasses to agarose-linked and to free ribonucleotides.
JO - Immunology
JF - Immunology
Y1 - 1981/03//
VL - 42
IS - 3
M3 - Article
SP - 451
EP - 457
PB - Wiley-Blackwell
SN - 00192805
AB - Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of θ antigen-bearing T cells comprising approximately 2% of the total thymocyte population as judged by a combined immunofluorescent/autoradiographic analysis. Thymocytes responsive to ATP and GTP are sensitive to cortisone suggesting that they are relatively immature T cells. ATP-responsive cells also preferentially aggregate with immature T cells when incubated with peanut agglutinin. GTP-responsive cells, on the other hand, do not. Nucleotides rendered insoluble by linkage to agarose via the ribose moiety are more active mitogenically at lower concentrations than either soluble nucleotides or even nucleotides linked to agarose via the nucleic acid base. The results are consistent with the view that the mitogenic response of thymocytes to nucleotides may be limited to as little as a single round of DNA synthesis and that such mitogenesis is stimulated at a site located on the plasma membrane. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - NUCLEOTIDES
KW - ADENOSINE triphosphatase
KW - GUANOSINE triphosphatase
KW - LYMPHOCYTES
KW - DNA synthesis
KW - IMMUNOLOGY
N1 - Accession Number: 13965109; Gregory, S. H. 1,2 Kern, M. 1; Affiliation: 1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205, U.S.A. 2: Department of Basic Science, Marquette University School of Dentistry, 604 North 16th Street, Milwaukee, Wisconsin 53233, U.S.A.; Source Info: Mar1981, Vol. 42 Issue 3, p451; Subject Term: T cells; Subject Term: NUCLEOTIDES; Subject Term: ADENOSINE triphosphatase; Subject Term: GUANOSINE triphosphatase; Subject Term: LYMPHOCYTES; Subject Term: DNA synthesis; Subject Term: IMMUNOLOGY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SCHULZ, S. C.
AU - VAN KAMMEN, D. P.
AU - BALOW, J. E.
AU - FLYE, M. W.
AU - BUNNEY JR., W. E.
T1 - Dialysis in Schizophrenia: A Double-Blind Evaluation.
JO - Science
JF - Science
Y1 - 1981/03/06/
VL - 211
IS - 4486
M3 - Article
SP - 1066
EP - 1068
SN - 00368075
AB - Eight chronic schizophrenia patients completed a research program consisting of ten weekly sessions of active hemodialysis and ten weekly sessions of sham dialysis in a double-blind design. Previous reports of iherapeutic efficacy were not substantiated. None of the patients improved during active dialysis;four patients worsened. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88017612; SCHULZ, S. C. 1; VAN KAMMEN, D. P. 1; BALOW, J. E. 2; FLYE, M. W. 3; BUNNEY JR., W. E. 4; Affiliations: 1: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20205; 3: Department of Surgery, University of Texas Medical Branch, Galveston 77550; 4: Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/ 6/1981, Vol. 211 Issue 4486, p1066; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - CHIANG, PETER K.
T1 - Conversion of 3T3-L1 Fibroblasts to Fat Cells by an Inhibitor of Methylation: Effect of 3-Deazaadenosine.
JO - Science
JF - Science
Y1 - 1981/03/13/
VL - 211
IS - 4487
M3 - Article
SP - 1164
EP - 1166
SN - 00368075
AB - 3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-LI fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-Ll fibroblasts to fat cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948192; CHIANG, PETER K. 1; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 3/13/1981, Vol. 211 Issue 4487, p1164; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - LEWIS, MICHAEL E.
AU - MISHKIN, MORTIMER
AU - BRAGIN, EVGENI
AU - BROWN, ROGER M.
AU - PERT, CANDACE B.
AU - PERT, AGU
T1 - Opiate Receptor Gradients in Monkey Cerebral Cortex: Correspondence with Sensory Processing Hierarchies.
JO - Science
JF - Science
Y1 - 1981/03/13/
VL - 211
IS - 4487
M3 - Article
SP - 1166
EP - 1169
SN - 00368075
AB - In order to obtain information on the possible functions of endogenous opiates in the primate cerebral cortex, we assessed the distribution of μ-like opiate receptors (which selectively bind 3H-labeled naloxone) and δ-like opiate receptors (which selectively bind 3H-labeled D-Ala2, D-Leu5-enkephalin) throughout the cerebral cortex of the rhesus monkey. Stereospecific [3H] naloxone binding sites increased in a gradient along hierarchically organized cortical systems that sequentially process modality-specific sensory information of a progressively more complex nature. Specific [3H]enkephalin binding sites, in contrast, were relatively evenly distributed throughout the cerebral cortex. These results, in combination with electrophysiological studies of monkeys and humans, suggest that μ-like opiate receptors may play a role in the affective filtering of sensory stimuli at the cortical level, that is, in emotion-induced selective attention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948193; LEWIS, MICHAEL E. 1; MISHKIN, MORTIMER 2; BRAGIN, EVGENI 3; BROWN, ROGER M. 4; PERT, CANDACE B. 5; PERT, AGU 5; Affiliations: 1: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Section on Cerebral Mechanisms, Laboratory of Neuropsychology, National Institute of Mental Health; 3: Central Research Institute of Reflexotherapeutics, Moscow, U.S.S.R.; 4: Division of Research, National Institute on Drug Abuse, Rockville, Maryland 20857; 5: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health; Issue Info: 3/13/1981, Vol. 211 Issue 4487, p1166; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ANFINSEN, CHRISTIAN B.
AU - COURANT, ERNEST D.
AU - FLORY, PAUL J.
AU - PRIPSTEIN, MORRIS
AU - RALSTON, ANTHONY
AU - ILTIS, HUGH H.
AU - COFFEY, JANICE C.
AU - DENTON, MELINDA F.
T1 - U.S.-Soviet Relations.
JO - Science
JF - Science
Y1 - 1981/03/27/
VL - 211
IS - 4489
M3 - Article
SP - 1369
EP - 1373
SN - 00368075
N1 - Accession Number: 88003270; ANFINSEN, CHRISTIAN B. 1; COURANT, ERNEST D. 2; FLORY, PAUL J. 3; PRIPSTEIN, MORRIS 4; RALSTON, ANTHONY 5; ILTIS, HUGH H. 6; COFFEY, JANICE C. 7; DENTON, MELINDA F. 8; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: Brookhaven National Laboratory, Upton, New York 11973; 3: Stanford University, Stanford, California 94305; 4: Lawrence Berkeley Laboratory, University of California, Berkeley 94720; 5: State University of New York, Buffalo, Amherst 14226; 6: Department of Botany, University of Wisconsin, Madison 53706; 7: Department of Biology, St. Mary's College, Raleigh, North Carolina 27611; 8: Department of Botany, University of Washington, Seattle 98195; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1369; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MERRIL, CARL R.
AU - GOLDMAN, DAVID
AU - SEDMAN, SYLVIA A.
AU - EBERT, MICHAEL H.
T1 - Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid Proteins.
JO - Science
JF - Science
Y1 - 1981/03/27/
VL - 211
IS - 4489
M3 - Article
SP - 1437
EP - 1438
SN - 00368075
AB - A new silver stain for electrophoretically separated polypeptides can be rapidly and easily used and can detect as little as 0.01 nanogram of protein per square millimeter. When employed with two-dimensional electrophoresis, it should permit qualitative and quantitative characterization of protein -distributions in body fluids and tissues. It has been used to demonstrate regional variations in cerebrospinal fluid proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003303; MERRIL, CARL R. 1; GOLDMAN, DAVID 2; SEDMAN, SYLVIA A. 2; EBERT, MICHAEL H. 2; Affiliations: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Clinical Science, National Institute of Mental Health; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1437; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SKOLNICK, P.
AU - MONCADA, V.
AU - BARKER, J. L.
AU - PAUL, S. M.
T1 - Pentobarbital: Dual Actions to Increase Brain Benzodiazepine Receptor Affinity.
JO - Science
JF - Science
Y1 - 1981/03/27/
VL - 211
IS - 4489
M3 - Article
SP - 1448
EP - 1450
SN - 00368075
AB - The binding of[³H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter Ɣ-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of[³H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [³H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these two types of compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003308; SKOLNICK, P. 1; MONCADA, V. 1; BARKER, J. L. 2; PAUL, S. M. 3; Affiliations: 1: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health; 3: Clinical Psychobiology Branch, National Institute of Mental Health, National Institutes of Health; Issue Info: 3/27/1981, Vol. 211 Issue 4489, p1448; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Giambra, Leonard M.
T1 - DAYDREAMING, ATTENTIONAL PROCESSES, AND CURIOSITY IN WHITE AMERICANS: RELIGIOUS, EDUCATIONAL, ECONOMIC, AND RESIDENCY INFLUENCES FOR A LIFE SPAN SAMPLE.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1981/04//
VL - 37
IS - 2
M3 - Article
SP - 262
EP - 275
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article focuses on daydreaming, attentional processes and curiosity in White Americans. A sample of 580 white men and 773 white women 17-92 years old were scored on the 33 factors of the Imaginal Processes Inventory. Variables used in this study were obtained through responses to a Biographical Questionnaire. Because both age and sex differences have been shown to affect daydreaming significantly, any analyses that desire to demonstrate the effect of other demographic variables must control for the possible confounding effects of age and sex.
KW - FANTASY
KW - ATTENTION
KW - CURIOSITY
KW - WHITES
KW - IMAGINATION
KW - PSYCHOLOGY
N1 - Accession Number: 15845586; Giambra, Leonard M. 1,2; Affiliation: 1: Gerontology Research Center (Baltimore), National Institute on Aging, National Institutes of Health Bethesda. 2: Department of Health and Human Services and the Baltimore City Hospital., Baltimore, Maryland.; Source Info: Apr1981, Vol. 37 Issue 2, p262; Subject Term: FANTASY; Subject Term: ATTENTION; Subject Term: CURIOSITY; Subject Term: WHITES; Subject Term: IMAGINATION; Subject Term: PSYCHOLOGY; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamaki, Kunihiko
AU - Fujiwara, Hiromi
AU - Katz, Stephen I.
T1 - The Role of Epidermal Cells in the Induction and Suppression of Contact Sensitivity.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/04//
VL - 76
IS - 4
M3 - Article
SP - 275
EP - 278
SN - 0022202X
AB - Haptens, such as trinitrochlorabenzene TNCB), bind to autologous skin proteins in the induction of allergic contact sensitivity. In order to clarify the role of epidermal cells in the induction of allergic contact sensitivity in vivo, we used trinitrobenzene sulfonate (TNBS)-conjugated epidermal cells (TNP-EC) in attempts to sensitize syngeneic mice. Spleen cells conjugate with TNBS (TNP-SC) were used for comparison. Four to 28 days after injection (via various routes) of the haptenated cells, contact sensitivity was assessed by the application of the same hapten to the ear. Sensitization regularly resulted form the subcutaneous injection of TNP-conjugated cells, and was longer lasting and was always stronger when TNP-EC were used rather than when TNP-SC were used. Neither TNP-EC nor TNP-SC injected intravenously resulted immunological hypo or unresponsiveness as assessed by subsequent painting with a sensitizing dose of TNCB. TNP-pvSC given intraperitoneally also did not sensitize when TNP-EC were given intraperitoneally. Both similarities and differences in the abilities of haptenated epidermal cells and spleen cells to induce sensitization and tolerance are described and the results are discussed in relation to the role of antigen-presenting cells contained in the haptenated cell populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - PROTEINS
KW - MICE
KW - SPLEEN
KW - INJECTIONS
KW - ANTIGENS
N1 - Accession Number: 12526115; Tamaki, Kunihiko 1 Fujiwara, Hiromi 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology and Immunology Branches, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Apr81, Vol. 76 Issue 4, p275; Subject Term: CONTACT dermatitis; Subject Term: PROTEINS; Subject Term: MICE; Subject Term: SPLEEN; Subject Term: INJECTIONS; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12526115
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12526115&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaoita, Hideo
AU - Briggaman, Robert A.
AU - Lawley, Thomas J.
AU - Provost, Thomas T.
AU - Katz, Stephen I.
T1 - Epidermolysis Bullosa Acquisita: Ultrastructural and Immunological Studies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/04//
VL - 76
IS - 4
M3 - Article
SP - 288
EP - 292
SN - 0022202X
AB - Four patients with epidermolysis bullosa acquisita were investigated using immunofluorescence, routine electron microscopic and immunoelectron microscopic techniques. Immunofluorescence studies demonstrated linear immunoglobulin and complement deposition along the dermal-epidermal junction. These findings are similar to those seem in skin of patients with bullous acquisita from that seen in bullous pemphigoid. Indirect immunoelectron microscopic findings suggest that epidermal basal cells of affected patients may secrete the dermal substances to which the antibodies bind. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMOLYSIS bullosa
KW - PATIENTS
KW - IMMUNOFLUORESCENCE
KW - SKIN
KW - IMMUNOGLOBULINS
KW - SECRETION
N1 - Accession Number: 12526124; Yaoita, Hideo 1 Briggaman, Robert A. 2 Lawley, Thomas J. 3 Provost, Thomas T. 4 Katz, Stephen I. 3; Affiliation: 1: Department of Dermatology University of Tsukuba Japan. 2: Department of Dermatology University of North Carolina, Chapel Hill North Carolina. 3: Department of Dermatology Branch, National Cancer Institute, Bethesda Maryland. 4: Department of Dermatology, John Hopkins University, Baltimore, Maryland, U.S.A.; Source Info: Apr81, Vol. 76 Issue 4, p288; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: PATIENTS; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SKIN; Subject Term: IMMUNOGLOBULINS; Subject Term: SECRETION; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12526124
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cordes, Rosemarie Selgas
AU - Eddy, Joyce
AU - Boyer, Marjorie
T1 - RN/MD TEAM-UP... WITH NO HASSLES.
JO - RN
JF - RN
Y1 - 1981/04//
VL - 44
IS - 4
M3 - Article
SP - 58
EP - 115
SN - 00337021
AB - Provides information on the team system approach of nurses and physicians at the medical Oncology Branch of the NCI-VA. Progress of the team system; Basic plan of the hospital; Changes that were made for the team system approach.
KW - TEAM nursing
KW - HEALTH care teams
N1 - Accession Number: 5124694; Cordes, Rosemarie Selgas 1; Eddy, Joyce 1; Boyer, Marjorie 1; Source Information: Apr81, Vol. 44 Issue 4, p58; Subject: TEAM nursing; Subject: HEALTH care teams; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 1659
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2013-42219-019
AN - 2013-42219-019
AU - Yarrow, Leon J.
AU - Zaslow, Martha
T1 - Review of The ecology of human development: Experiments by nature and design.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1981/04//
VL - 51
IS - 2
SP - 363
EP - 365
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42219-019. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Child and Family Research Branch, National Institute of Child Health and Human Development, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Ecological Factors; Experimental Design; Human Development; Theories. Minor Descriptor: Ecology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Bronfenbrenner, Urie. The ecology of human development: Experiments by nature and design=330 pp. $16.50. Harvard University Press, Cambridge, Mass; 1979. Page Count: 3. Issue Publication Date: Apr, 1981.
AB - Reviews the book, The Ecology of Human Development: Experiments by Nature and Design by Urie Bronfenbrenner (1979). When Roger Barker began his ecological studies, he and his collaborators gave rich descriptions of children and adults in their natural settings. These finely embroidered pictures suggested the complexity of apparently simple everyday settings and events. In this book, Bronfenbrenner presents a theoretical perspective for ecological research on human development that differs in many ways from Barker's orientation. Three research paradigms are presented: studies of ecological transition, transforming experiments. and studies of contrasting environments. An important aspect of this book is Bronfenbrenner's critique of the laboratory as a context for observing human development. Bronfenbrenner gives evidence that the laboratory, as an unfamiliar and atypical context for both parents and children, evokes behavior that is different from behavior in natural contexts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human development
KW - ecology
KW - experiment design
KW - experiment nature
KW - theoretical perspectives
KW - 1981
KW - Ecological Factors
KW - Experimental Design
KW - Human Development
KW - Theories
KW - Ecology
KW - 1981
U2 - Bronfenbrenner, Urie. (1979); The ecology of human development: Experiments by nature and design; 330 pp. $16.50. Harvard University Press, Cambridge, Mass
DO - 10.1037/h0098898
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42219-019&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - MAGNANI, JOHN L.
AU - BROCKHAUS, MANFRED
AU - SMITH, DAVID F.
AU - GINSBURG, VICTOR
AU - BLASZCZYK, MAGDALENA
AU - MITCHELL, KENNETH F.
AU - STEPLEWSKI, ZENON
AU - KOPROWSKI, HILARY
T1 - A Monosialoganglioside Is a MonocIonal Anribody-Defined Antigen of Colon Carcinoma.
JO - Science
JF - Science
Y1 - 1981/04/03/
VL - 212
IS - 4490
M3 - Article
SP - 55
EP - 56
SN - 00368075
AB - The antigen of a monoclonal antibody that is specificfor cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-4abeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Immunoglobulins
KW - Colon cancer
KW - Serum
KW - Hybridomas
KW - Cell lines
N1 - Accession Number: 84928437; MAGNANI, JOHN L. 1; BROCKHAUS, MANFRED 1; SMITH, DAVID F. 1; GINSBURG, VICTOR 1; BLASZCZYK, MAGDALENA 2; MITCHELL, KENNETH F. 2; STEPLEWSKI, ZENON 2; KOPROWSKI, HILARY 2; Affiliations: 1: National Institute of Arthritis, Metabolism, Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; Issue Info: 4/ 3/1981, Vol. 212 Issue 4490, p55; Thesaurus Term: Antigens; Subject Term: Immunoglobulins; Subject Term: Colon cancer; Subject Term: Serum; Subject Term: Hybridomas; Subject Term: Cell lines; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Negishi, Masahiko
AU - Jensen, Nancy M.
AU - Garcia, Gordon S.
AU - Nebert, Daniel W.
T1 - Structural Gene Products of the Murine Ali Complex.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/04/15/
VL - 115
IS - 3
M3 - Article
SP - 585
EP - 594
PB - Wiley-Blackwell
SN - 00142956
AB - Antibodies against mouse-liver microsomal cytochromes P1-450 and P-448, two polycyclic aromatic-inducible cytochromes, were previously developed [Negishi, M. and Nebert, D. W. (1979) J. Riol. Chem. 254. 11015-110231]. Liver microsomes from 3-methylcholanthrene-treated and phenobarbital-treated and control adult mice and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated adult and fetal mice were examined. Immunoprecipitable radioactivity was measured, following labeling with pyridoxal phosphate/NaB[3H]4 or with 125I-labeled p-aminosulfohenzoie acid/NaNO2 in vitro or with [3H]leucine, [14C]glucosamine, or [32P]O4 in viva (a) Induction of cytochrome P1-450 occurs developmentally earlier in gestation titan induction of cytochrome P-448 when the mother is treated with polycyclic aromatic compounds. (b) There appears to be a basal form of cytochrome P-448 but no cytochrome P1-450 in control liver microsomes inducibility of cytochrome P-448 thus ranges between 5-12-fold, whereas that of P1-450 is infinite. (c) Phenobarbital pretreatment induces no detectable P1-450 or P-448. (d) P-448 appears to be either greater in concentration than P1-450 in the membrane or more exposed than P1-450 on the microsomal membrane surface. (c) By the radioimmunoassay methods used, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced P1-450 and P-448 in Ah-nonresponsive mice are indistinguishable from those in Ah-responsive mice; this is true in both the fetus and the adult. (f) Compared with P-448 expression, the expression of P1-450 is more closely associated with 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity, and these two structural gene products are apparently regulated independently. (g) P-148 but not P1-450 appears to be a glycoprotein. These data illustrate further differences between two forms of polycyclic aromatic-inducible P50 in mouse liver. Neither P1-450 nor P-448 appears to be a phosphoprotein. Neither anti-(P1-450) nor anti-(P-448) precipitates any forms of liver microsomal P-450 from β-naphthoflavone-treated adult rabbits and, conversely. anti-LM4 (the antibody to rabbit liver microsomal P-450 form 4) does not precipitate any forms of liver microsomal P-450 from 3-methylcholanthrene-treated C57BL/6N mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - IMMUNOGLOBULINS
KW - AMINO acids
KW - PREGNANCY
KW - LIVER
KW - MICE
N1 - Accession Number: 13101409; Negishi, Masahiko 1 Jensen, Nancy M. 1 Garcia, Gordon S. 1 Nebert, Daniel W. 1; Affiliation: 1: Development Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda.; Source Info: 4/15/81, Vol. 115 Issue 3, p585; Subject Term: GENES; Subject Term: IMMUNOGLOBULINS; Subject Term: AMINO acids; Subject Term: PREGNANCY; Subject Term: LIVER; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldhammer, Alan R.
AU - Wolff, J.
AU - Cook, G. Hope
AU - Berkowitzt, Steven A.
AU - Klee, Claude B.
AU - Manclark, C. R.
AU - Hewlett, Erik L.
T1 - Spurious Protein Activators of Bordetella pertussis Adenylated Cyclase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/04/15/
VL - 115
IS - 3
M3 - Article
SP - 605
EP - 609
PB - Wiley-Blackwell
SN - 00142956
AB - A variety of proteins and tissue preparations (rabbit erythrocyte lysate, catalase, peroxidase, creatine phosphokinase, and lima bean trypsin inhibitor) contain protein activator(s) of the extracellular adenylate cyclase of intact Bordetella pertussis organisms. Stimulation of adenylate cyclase activity of up to 1000-fold over basal activity can be obtained. Activation of the adenylate cyclase is due to the presence of calmodulin in these protein preparations. The criteria to establish this were: Ca2+ dependence of the activation, inhibition by trifluoperazine, heat stability of the activator, chromatographic behavior like authentic calmodulin, and stimulation of cyclic nucleotide phosphodiesterase by the activators The great sensitivity of the B. pertussis adenylate cyclase assay makes this and ideal system for the detection or trace amounts of calmodulin, in the presence of large amounts of other proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - BORDETELLA pertussis
KW - PERTUSSIS toxin
KW - PEROXIDASE
KW - OXIDOREDUCTASES
KW - TRYPSIN
N1 - Accession Number: 13101575; Goldhammer, Alan R. 1 Wolff, J. 1 Cook, G. Hope 1 Berkowitzt, Steven A. 1 Klee, Claude B. 1 Manclark, C. R. 1 Hewlett, Erik L. 1; Affiliation: 1: National lnstitutes of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda.; Source Info: 4/15/81, Vol. 115 Issue 3, p605; Subject Term: PROTEINS; Subject Term: BORDETELLA pertussis; Subject Term: PERTUSSIS toxin; Subject Term: PEROXIDASE; Subject Term: OXIDOREDUCTASES; Subject Term: TRYPSIN; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Resch, Klaus
AU - Wood, Theodore
AU - Northoff, Hinnak
AU - Cooper, Herbert L.
T1 - Microtubules: Are They Involved in the Initiation of Lymphocyte Activation?
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/04/15/
VL - 115
IS - 3
M3 - Article
SP - 659
EP - 664
PB - Wiley-Blackwell
SN - 00142956
AB - Purified human blood lymphocytes were stimulated with concanavalin A or phytohemagglutinin. DNA synthesis was measured with 2-h pulses of [3H)thymidine between 48 h and 73 h after stimulation. Colchicine, at concentrations between 0.1 μM and 10 μM, suppressed consequent DNA synthesis without affecting viability of the cells when added at any time up to 18 h before incorporation of [3thymidine was assessed. In concanavalin-A-stimulated lymphocytes, removal of the mitogen by methyl α-mannoside only prevented proliferation when added initially, hut was without any effect when added after 20 h of stimulation, regardless of when DNA synthesis was measured. Thus, there was a period after 20 h of concanavalin A stimulation, when DNA synthesis was still sensitive to colchicine, but no longer required the presence of the mitogen. Colchicine also suppressed incorporation of [3H]leucine into protein, in resting as well as mitogen-stimulated lymphocytes. Similarly, colchicine decreased amino acid transport, as determined by uptake of α-amino-isobutyrate, which appeared to be the rate-limiting step in the incorporation of amino acids into protein in colchicine-treated cells. When the rate of protein synthesis was followed by the relative distribution of ribosomal particles, especially the increase of polysomes in activated lymphocytes, colchicine was without any detectable effect. The early increase in the incorporation of [14C]oleate into phospholipids was identical in the presence or absence of the microtubule-active drug. The data strongly suggest that microtubule are not involved in the initiation of lymphocyte growth or mitogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD
KW - LYMPHOCYTES
KW - PHYTOHEMAGGLUTININS
KW - PLANT lectins
KW - AMINO acids
KW - RIBOSOMES
N1 - Accession Number: 13101657; Resch, Klaus 1,2,3 Wood, Theodore 1,2,3 Northoff, Hinnak 1,2,3 Cooper, Herbert L. 1,2,3; Affiliation: 1: Cellular and Molecular Physiology Section, Laboratory of Pathophysiology, National Institutes of Health, Bethesda. 2: Institut für Virusforsehung, Deutsches Krebsforschungszentrum, Heidelberg. 3: Institut für Immunologie der Universität, Heidelberg.; Source Info: 4/15/81, Vol. 115 Issue 3, p659; Subject Term: BLOOD; Subject Term: LYMPHOCYTES; Subject Term: PHYTOHEMAGGLUTININS; Subject Term: PLANT lectins; Subject Term: AMINO acids; Subject Term: RIBOSOMES; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wahli, Walter
AU - Dawid, Igor B.
AU - Ryffel, Gerhart U.
AU - Weber, Rudolf
T1 - Vitellogenesis and the Vitellogenin Gene Family.
JO - Science
JF - Science
Y1 - 1981/04/17/
VL - 212
IS - 4492
M3 - Article
SP - 298
EP - 304
SN - 00368075
N1 - Accession Number: 88003359; Wahli, Walter 1,2; Dawid, Igor B. 1; Ryffel, Gerhart U.; Weber, Rudolf 3; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Institut de Biologie Animale, University de Lausanne, CH-1005 Lausanne, Switzerland. G. U. Ryffel; 3: Department of Zoology, University of Bern, CH- 3012 Bern, Switzerland; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p298; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BROWNSTEIN, MICHAEL J.
T1 - Neuroendocrinology.
JO - Science
JF - Science
Y1 - 1981/04/17/
VL - 212
IS - 4492
M3 - Article
SP - 320
EP - 320
SN - 00368075
N1 - Accession Number: 88003374; BROWNSTEIN, MICHAEL J. 1; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p320; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NAGAO, KENJI
AU - YOKORO, KENJIRO
AU - AARONSON, STUART A.
T1 - Continuous Lines of Basophil/Mast Cells Derived from Normal Mouse Bone Marrow.
JO - Science
JF - Science
Y1 - 1981/04/17/
VL - 212
IS - 4492
M3 - Article
SP - 333
EP - 335
SN - 00368075
AB - Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophillmast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003382; NAGAO, KENJI 1; YOKORO, KENJIRO 2; AARONSON, STUART A. 3; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima 730, Japan; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p333; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARKER, JEFFERY L.
AU - MATHERS, DAVID A.
T1 - GABA Analogues Activate Channels of Different Duration on Cultured Mouse Spinal Neurons.
JO - Science
JF - Science
Y1 - 1981/04/17/
VL - 212
IS - 4492
M3 - Article
SP - 358
EP - 361
SN - 00368075
AB - Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to -y-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003393; BARKER, JEFFERY L. 1,2; MATHERS, DAVID A. 1,2; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Neurological; 2: Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/17/1981, Vol. 212 Issue 4492, p358; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DEAN, ANN
AU - ERARD, FRANCOIS
AU - SCHNEIDER, ARTHUR B.
AU - SCHECHTER, ALAN N.
T1 - Induction of Hemoglobin Accumulation in Human K562 Cells by Hemin Is Reversible.
JO - Science
JF - Science
Y1 - 1981/04/24/
VL - 212
IS - 4493
M3 - Article
SP - 459
EP - 461
SN - 00368075
AB - Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in 1562 cells does not depend on irreversible differentiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84928492; DEAN, ANN 1; ERARD, FRANCOIS 1; SCHNEIDER, ARTHUR B. 1,2; SCHECHTER, ALAN N. 1; Affiliations: 1: Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; 2: Michael Reese Hospital, University of Chicago, Chicago, Ill. 60616; Issue Info: 4/24/1981, Vol. 212 Issue 4493, p459; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fredrickson, Donald S.
AU - Bertrand, Anson
T1 - Federally supported human nutrition research, training, and education.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1981/05//
VL - 34
IS - 5
M3 - Article
SP - 957
EP - 958
SN - 00029165
N1 - Accession Number: 94381407; Fredrickson, Donald S. 1; Bertrand, Anson 2; Affiliations: 1: Director, National Institutes of Health, DHHS, Chairman, Committee on Health and Medicine; 2: Administrator, Science and Education Administration, USDA, Chairman, Committee on Food and Renewable Resources; Issue Info: May1981, Vol. 34 Issue 5, p957; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - Berman, J. D.
AU - Dwyer, D. M.
T1 - Expression of Leishmania antigen on the surface membrane of infected human macrophages in vitro.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/05//
VL - 44
IS - 2
M3 - Article
SP - 342
EP - 348
PB - Wiley-Blackwell
SN - 00099104
AB - Resolution of leishmaniasis is associated with host immunological responsiveness to parasite antigens. In clinical disease. Leishmania are found as amastigoles contained within macrophages. We investigated the possibility that Leishmania antigens arc expressed on the infected macrophage surface by reacting infected macrophages with antibody to Leishmania. In Vitro-infected human monocyte-derived macrophages were labelled with antibody lo amastigotes when examined with immunofluorescent or immunoelectron microscopic techniques. Infected macrophages were poorly labelled by antibody to promastigotes (insect forms of Leishmania). Certain antisera that reacted with the surface membranes of amastigotes did not label the infected macrophage surface. These results indicate that human macrophages infected in vitro express Leishmania amastigote antigen(s) on their surface membranes, that such antigen(s)may not be present in large quantities in promastigotes and that certain antigen(s) on the amastigote surface are not expressed on the surface membranes of infected macrophages. [ABSTRACT FROM AUTHOR]
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KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - LEISHMANIASIS
KW - IMMUNE serums
KW - MACROPHAGES
KW - KILLER cells
N1 - Accession Number: 15944844; Berman, J. D. 1 Dwyer, D. M. 1; Affiliation: 1: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA.; Source Info: May1981, Vol. 44 Issue 2, p342; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: LEISHMANIASIS; Subject Term: IMMUNE serums; Subject Term: MACROPHAGES; Subject Term: KILLER cells; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaar, Mina
AU - Stanley, John R.
AU - Katz, Stephen I.
T1 - Retinoic Acid Delays the Terminal Differentiation of Keratinocytes in Suspension Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/05//
VL - 76
IS - 5
M3 - Article
SP - 363
EP - 366
SN - 0022202X
AB - The effect of retinoic acid (RA) on the terminal differentiation of guinea pig keratinocytes maintained in suspension culture was studied. Keratinocytes obtained from trypsinized guinea pig skin were suspended in medium containing 20% calf serum and 1.2% methyl cellulose. RA, which was added at the beginning of culture, delayed differentiation as judged by a decrease in the percent of cells that developed disulfide cross-linked keratin (sodium dodecyl sulfate insoluble cells) and cornified envelopes (sodium dodecyl sulfate and 2-mercaptoethanol insoluble cells). RA inhibited differentiation maximally at 5 μg/ml on day 3 of a 5 day culture; concentrations as low as .005 μg/ml were also inhibitory. Because the disulfide cross-linking of keratin and the formation of cornified envelopes are thought to occur when the cell membrane becomes permeable, we determined whether RA inhibited these processes by stabilizing the cell membrane. Two agents (ionophore X537A and Triton X-100) which permeabilize cell membranes rapidly reversed the inhibitory effect of RA on cornified envelope formation. In addition, when cultured with RA, the percent of cells which became permeable to trypan blue was reduced, also suggesting that RA acts on the cell membrane. These studies show that RA can inhibit keratinocyte differentiation by stabilizing the cell membrane thereby delaying transition from a living epidermal cell to a dead cornified cell. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRETINOIN
KW - KERATINOCYTES
KW - SKIN tests
KW - CELLULOSE
KW - CELL membranes
KW - KERATIN
N1 - Accession Number: 12520026; Yaar, Mina 1 Stanley, John R. 1,2 Katz, Stephen I. 2; Affiliation: 1: Laboratory of Developmental Biology and Anomalies of the National Institute of Dental Research, Bethesda, Maryland, U.S.A. 2: Dermatology Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May81, Vol. 76 Issue 5, p363; Subject Term: TRETINOIN; Subject Term: KERATINOCYTES; Subject Term: SKIN tests; Subject Term: CELLULOSE; Subject Term: CELL membranes; Subject Term: KERATIN; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12520026
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ER -
TY - JOUR
AU - RESNICK, M. A.
AU - KASIMOS, J. N.
AU - GAME, J. C.
AU - BRAUN, R. J.
AU - ROTH, R. M.
T1 - Changes in DNA During Meiosis in a Repair-Deficient Mutant (rad 52) of Yeast.
JO - Science
JF - Science
Y1 - 1981/05//5/ 1/1981
VL - 212
IS - 4494
M3 - Article
SP - 543
EP - 545
SN - 00368075
AB - The kinetic patterns ofDNA synthesis in vild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84928549; RESNICK, M. A. 1; KASIMOS, J. N. 2; GAME, J. C. 3; BRAUN, R. J. 4; ROTH, R. M. 4; Affiliations: 1: National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, Research Triangle Park, North Carolina 27709; 2: Department of Biology, illinois Institute of Technology, Chicago 60616; 3: Department of Genetics, University of California, Berkeley 94720; 4: Department of Biology, Illinois Institute of Technology; Issue Info: 5/ 1/1981, Vol. 212 Issue 4494, p543; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - KAPLAN, ANN E.
AU - WEISS, ELLEN R.
AU - BYRNE, SHARON T.
AU - EL-TORKEY, NABIL M.
AU - MARGOLIS, SAM A.
T1 - Purified Reduced Nicotinamide Adenine Dinucleotide: Responses to Lactate Dehydrogenase Isozymes from Three Cell Sources.
JO - Science
JF - Science
Y1 - 1981/05//5/ 1/1981
VL - 212
IS - 4494
M3 - Article
SP - 553
EP - 555
SN - 00368075
AB - Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinicleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purifiedfrom rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not accouint for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The resullts suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84928554; KAPLAN, ANN E. 1; WEISS, ELLEN R. 1; BYRNE, SHARON T. 1; EL-TORKEY, NABIL M. 1; MARGOLIS, SAM A. 2; Affiliations: 1: Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland 20205; 2: Organic Analytical Research Division, Center for Analytical Chemistry, National Bureau of Standards, Washington, D.C. 20234; Issue Info: 5/ 1/1981, Vol. 212 Issue 4494, p553; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hemmings, Brian A.
T1 - Reactivation of the Phospho Form of the NAD-Dependent Glutamate Dehydrogenase by a Yeast Protein Phosphatase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/05/02/
VL - 116
IS - 1
M3 - Article
SP - 47
EP - 50
PB - Wiley-Blackwell
SN - 00142956
AB - A protein phosphatase was isolated from the yeast, Candida utilities, which could reactivate (dephosphorylate) the phosphorylated form of the NAD-dependent glutamate dehvdrogenase. The protein could also dephosphory1ate casein, histone and kemptide (a heptapeptide corresponding to the phosphorylation site of liver pyruvate kinase).Reactivation of the phosphorylated glutamate dehydrogenase was stimulated by the simultaneous addition of NAD and L-glutamate; 2-oxoglutarate, NH4+ and NADH had no effect. The reactivation of phosphorylated glutamate dehydrogenase could be inhibited by phosphate, pyrophosphate and fluoride. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YEAST
KW - GLUTAMATE dehydrogenase
KW - DEHYDROGENASES
KW - CANDIDA
KW - BIOCHEMISTRY
KW - MEDICAL sciences
N1 - Accession Number: 13924740; Hemmings, Brian A. 1; Affiliation: 1: Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda; Source Info: 5/2/81, Vol. 116 Issue 1, p47; Subject Term: YEAST; Subject Term: GLUTAMATE dehydrogenase; Subject Term: DEHYDROGENASES; Subject Term: CANDIDA; Subject Term: BIOCHEMISTRY; Subject Term: MEDICAL sciences; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 4p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - HAASE, A. T.
AU - VENTURA, P.
AU - GIBBS JR., C. J.
AU - TOURTELLOTTE, W. W.
T1 - Measles Virus Nucleotide Sequences: Detection by Hybridization in situ.
JO - Science
JF - Science
Y1 - 1981/05/08/
VL - 212
IS - 4495
M3 - Article
SP - 672
EP - 675
SN - 00368075
AB - A tritium-labeled probe that detects measles virus nucleotide sequences was hybridized in situ to cells infected with measles virus and to sections of brain tissue from patients with subacute sclerosing panencephalitis and from patients with multiple sclerosis. The measles virus genome was detected in many cells in subacute sclerosing panencephalitis where this virus would have been missed by methods such as immunofluorescence. Measles virus sequences were also found in two foci in one of four cases of multiple sclerosis. This refined method of hybridization in situ, which can be useful in the search for covert virus infections of man, provides evidence that viruses may be involved in multiple sclerosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003424; HAASE, A. T. 1; VENTURA, P. 1; GIBBS JR., C. J. 2; TOURTELLOTTE, W. W. 3,4; Affiliations: 1: Veterans Administration Medical Center and University of California, San Francisco 94121; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: Neurology and Research Services, Veterans Administration, Wadsworth Medical Center, Los Angeles, California 90073; 4: Department of Neurology, University of California, Los Angeles 90073; Issue Info: 5/ 8/1981, Vol. 212 Issue 4495, p672; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HUNNINGHAKE, G. W.
AU - DAVIDSON, J. M.
AU - RENNARD, S.
AU - SZAPIEL, S.
AU - GADEK, J. E.
AU - CRYSTAL, R. G.
T1 - Elastin Fragments Attract Macrophage Precursors to Diseased Sites in Pulmonary Emphysema.
JO - Science
JF - Science
Y1 - 1981/05/22/
VL - 212
IS - 4497
M3 - Article
SP - 925
EP - 927
SN - 00368075
AB - This study suggests one mechanism by which alveolar macrophages accumulate in the lung in pulmonary emphysema: elastin fragments generated at the diseased sites are potent chemoattractants for monocytes, the precursors of the macrophages. The most chemotactic elastin fragments have a molecular weight between 10,000 and 50,000 and are active at concentrations as low as 3 nanograms per milliliter. By comparison, elastin fragments with higher molecular weights and desmosines are active only at concentrations greater than 0.3 microgram per milliliter. In addition, preincubation of monocytes with the 10,000- to 50,000-dalton elastin impairs the ability of the cells to migrate toward elastin fragments but not toward activated serum. Fragments of tropoelastin are not chemotactic for monocytes. Because elastin, but not tropoelastin, contains lysyl-derived cross-links, these structures may be the active chemotactic site on the elastin fragments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948237; HUNNINGHAKE, G. W. 1; DAVIDSON, J. M. 1; RENNARD, S. 1; SZAPIEL, S. 1; GADEK, J. E. 1; CRYSTAL, R. G. 1; Affiliations: 1: Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p925; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOTTLIEB, MICHAEL
AU - DWYER, DENNIS M.
T1 - Protozoan Parasite of Humans: Surface Membrane with Externally Disposed Acid Phosphatase.
JO - Science
JF - Science
Y1 - 1981/05/22/
VL - 212
IS - 4497
M3 - Article
SP - 939
EP - 941
SN - 00368075
AB - Plasma membranes isolated from the protozoan parasite Leishmania donovani were enriched in acid phosphatase (E.C. 3.1.3.2) activity. Cytochemically, the enzyme was distributed uniformly on the surface of intact cells and was localized on the externalface of isolated membranes. Physical characteristics and orientation of the membrane-bound enzyme suggest that the organism is adapted for existence in hydrolytic environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948243; GOTTLIEB, MICHAEL 1; DWYER, DENNIS M. 2; Affiliations: 1: Department of Pathobiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205; 2: Cell Biology and Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p939; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BLAIR, D. G.
AU - OSKARSSON, M.
AU - WOOD, T. G.
AU - McCLEMENTS, W. L.
AU - FISCHINGER, P. J.
AU - VAN DE WOUDE, G. G.
T1 - Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis.
JO - Science
JF - Science
Y1 - 1981/05/22/
VL - 212
IS - 4497
M3 - Article
SP - 941
EP - 943
SN - 00368075
AB - The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA's with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948244; BLAIR, D. G. 1; OSKARSSON, M. 2; WOOD, T. G. 2; McCLEMENTS, W. L. 2; FISCHINGER, P. J. 3; VAN DE WOUDE, G. G. 4; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21701; 2: Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Viral Carcinogenesis, National Cancer Institute; 4: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p941; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KAPATOS, GREGORY
AU - KAUFMAN, SEYMOUR
T1 - Peripherally Administered Reduced Pterins Do Enter the Brain.
JO - Science
JF - Science
Y1 - 1981/05/22/
VL - 212
IS - 4497
M3 - Article
SP - 955
EP - 956
SN - 00368075
AB - The content of tetrahydrobiopterin in rat brain was doubled by peripherally administered tetrahydrobiopterin, with the natural 1 diastereoisomer more effective than the unnatural d configuration. The model pteridine, 6-methyltetrahydropterin was ten times more efficient than tetrahydrobiopterin in crossing the bloodbrain barrier, and striatal concentrations of 6-methyltetrahydropterin remained elevated for 2 hours, declining with a half-life of 3 hours. While no evidence for a specific uptake mechanism for concentrating 6-methyltetrahydropterin in cells containing tetrahydrobiopterin was detected, the pterin was found in its presumed site of action, the nerve terminal. Replacement therapy with reduced pterins may therefore be effective in the treatment of the neurological disorders associated with the variantforms of hyperphenylalaninemia that resultfrom defects in the biosynthesis or metabolism of tetrahydrobiopterin within the central nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84948250; KAPATOS, GREGORY 1; KAUFMAN, SEYMOUR; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/22/1981, Vol. 212 Issue 4497, p955; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WASKOW, IRENE ELKIN
AU - PARLOFF, MORRIS P.
AU - OSTOW, MORTIMER
AU - STRUPP, HANS H.
AU - DAWES, ROBYN M.
T1 - Depression Study.
JO - Science
JF - Science
Y1 - 1981/05/29/
VL - 212
IS - 4498
M3 - Article
SP - 984
EP - 986
SN - 00368075
N1 - Accession Number: 88003437; WASKOW, IRENE ELKIN 1; PARLOFF, MORRIS P. 2; OSTOW, MORTIMER; STRUPP, HANS H. 3; DAWES, ROBYN M. 4,5; Affiliations: 1: Psychotherapy of Depression Collaborative Research Program, National Institute of Mental Health, Rockville, Maryland 20857; 2: Psychotherapy Research Branch, National Institute of Mental Health; 3: Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240; 4: Center for Advanced Study, Behavioral Sciences, Stanford, California 94305; 5: Department of Psychology, University of Oregon, Eugene 97403; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p984; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TULLY, JOSEPH G.
AU - ROSE, DAVID L.
AU - YUNKER, CONRAD E.
AU - CORY, JACK
AU - WHITCOMB, ROBERT F.
AU - WILLIAMSON, DAVID L.
T1 - Helical Mycoplasmas (Spiroplasmas) from Ixodes Ticks.
JO - Science
JF - Science
Y1 - 1981/05/29/
VL - 212
IS - 4498
M3 - Article
SP - 1043
EP - 1045
SN - 00368075
AB - A new spiroplasma isolated from Ixodes pacificus collected in Oregon was serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could also be isolated in tick cell cultures. Discovery of a newfastidious mycoplasma in ticks of fers opportunities to explore the possible role of these agents in human and animal diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003473; TULLY, JOSEPH G. 1; ROSE, DAVID L. 1; YUNKER, CONRAD E. 2; CORY, JACK 2; WHITCOMB, ROBERT F. 3; WILLIAMSON, DAVID L. 4; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Epidemiology Branch, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 3: Insect Pathology Laboratory, Plant Protection Institute, SEA-AR, U.S. Department of Agriculture, Beltsville, Maryland 20705; 4: Department of Anatomical Sciences, State University of New York, Stony Brook 11794; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p1043; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ESKAY, R. L.
AU - FURNESS, J. F.
AU - LONG, R. T.
T1 - Substance P Activity in the Bullfrog Retina: Localization and Identification in Several Vertebrate Species.
JO - Science
JF - Science
Y1 - 1981/05/29/
VL - 212
IS - 4498
M3 - Article
SP - 1049
EP - 1051
SN - 00368075
AB - Immunoreactive substance P is present in the bullfrog retina, possibly in two types of stratified amacrine cells, with their somas in the inner nuclear layer and their neuronal processes entering the inner plexiform layer and ramifying in sublayers 3 or 4 (or both). Occasionally, polygonal somas positive for substance P were found in the ganglion cell layer. Approximately 75 percent of the cell bodies positive for substance P and 65 percent of the radioimmunoassayable substance P were found in the superior half of the frog retina. On the basis of high-performance liquid chromatography, the immunoreactive substance P in the neural retina of the rat, monkey, or chick is similar to synthetic substance P, whereas this is not true of the immunoreactive substance P in the bullfrog or carp retina. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003476; ESKAY, R. L. 1; FURNESS, J. F. 1; LONG, R. T. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/29/1981, Vol. 212 Issue 4498, p1049; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simopoulos, Artemis P.
T1 - Highlights of the National Institutes of Health Program in Biomedical and Behavioral Nutrition and Research Training--with the emphasis on total parenteral and enteral nutrition.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1981/06//
VL - 34
IS - 6
M3 - Article
SP - 1187
EP - 1190
SN - 00029165
N1 - Accession Number: 94406781; Simopoulos, Artemis P. 1; Affiliations: 1: Chairman, NIH-Nutrition Coordinating Committee, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: Jun1981, Vol. 34 Issue 6, p1187; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Costas Jr., Raul
AU - Garcia-Palmieri, Mario R.
AU - Sorlie, Paul
AU - Hertzmark, Ellen
T1 - Coronary Heart Disease Risk Factors in Men With Light and Dark Skin in Puerto Rico.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/06//
VL - 71
IS - 6
M3 - Article
SP - 614
EP - 619
PB - American Public Health Association
SN - 00900036
AB - The association of skin color with coronary heart disease risk factors was studied in 4,000 urban Puerto Rican men, Skin color on the inner upper arm was classified according to the von Luschan color tiles. Using this grading, men were separated into two groups of light or dark skin color. The dark group had a lower socioeconomic status (SES) based on income, education, and occupation. Dark men had slightly higher mean systolic blood pressures (SBP) and lower mean serum cholesterol levels than the light, but the relative weights and cigarette smoking habits of both groups were similar. After controlling for the differences in SES, skin color showed a small but statistically significant association with SBP. Whether this association with skin color represents genetic or environmental influences on SBP could not be determined from this study. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY heart disease
KW - HUMAN skin color
KW - SOCIOECONOMIC factors
KW - MEN
KW - PUERTO Rico
N1 - Accession Number: 4948982; Costas Jr., Raul 1 Garcia-Palmieri, Mario R. 1 Sorlie, Paul 2 Hertzmark, Ellen 1; Affiliation: 1: Department of Medicine, School of Medicine, University of Puerto Rico, San Juan, PR 2: Health Statistician, Biometrics Research Branch, National Heart, Lung, and Blood Institute, Federal Building, Room 2A06, Bethesda, MD 20205; Source Info: Jun81, Vol. 71 Issue 6, p614; Subject Term: CORONARY heart disease; Subject Term: HUMAN skin color; Subject Term: SOCIOECONOMIC factors; Subject Term: MEN; Subject Term: PUERTO Rico; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Brody, Jacob A.
T1 - Dr. Brody's Response.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/06//
VL - 71
IS - 6
M3 - Letter
SP - 650
EP - 650
PB - American Public Health Association
SN - 00900036
AB - A reply by Jacob A. Brody to two letters to editor about his article "Manning the Battlements of Research Epidemiology," published in a 1981 issue, is presented.
KW - LETTERS to the editor
KW - EPIDEMIOLOGY
N1 - Accession Number: 22492749; Brody, Jacob A. 1; Affiliation: 1: Associate Director for Epidemiology, Demography, and Biometry Program, National Institute on Aging, DHHS, PHS, NIH, Bethesda, MD 20205; Source Info: Jun81, Vol. 71 Issue 6, p650; Subject Term: LETTERS to the editor; Subject Term: EPIDEMIOLOGY; Number of Pages: 1/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moment, Gairdner B.
T1 - RISK MONEY FOR RESEARCH AND THE PEER REVIEW SYSTEM.
JO - BioScience
JF - BioScience
Y1 - 1981/06//
VL - 31
IS - 6
M3 - Editorial
SP - 421
EP - 421
SN - 00063568
AB - The article comments on the peer review system for awarding grants which slows down scientific advancement. It informs that both the U.S. National Science Foundation and National Institutes of Health have studied the possibility of bias based on sex or race and for or against Ivy League institutions or investigators. It reports that according to a survey, granting officers agreed that an average panel member is reluctant to recommend proposals that stray very far from the usual path.
KW - Research grants
KW - Peer review (Professional performance)
KW - United States
KW - National Science Foundation (U.S.)
N1 - Accession Number: 28051170; Moment, Gairdner B. 1; Affiliations: 1 : Professor of Biology Emeritus, Coucher College Guest Scientist, National Institute on Aging Gerontology Research Center Baltimore, MD 21224; Source Info: Jun1981, Vol. 31 Issue 6, p421; Subject Term: Research grants; Subject Term: Peer review (Professional performance); Subject: United States; Number of Pages: 2/3p; Document Type: Editorial; Full Text Word Count: 848
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Yarosh, Daniel B.
T1 - STUDYING MACROMOLECULES.
JO - BioScience
JF - BioScience
Y1 - 1981/06//
VL - 31
IS - 6
M3 - Book Review
SP - 458
EP - 458
SN - 00063568
AB - The article reviews the book "Introduction of Macromolecules Into Viable Mammalian Cells," Vol. 1, "Wistar Symposium Series," edited by Renato Baserga, Carlo Croce and Giovanni Rovera.
KW - Macromolecules
KW - Nonfiction
KW - Baserga, Renato
KW - Croce, Carlo
KW - Rovera, Giovanni
KW - Introduction of Macromolecules Into Viable Mammalian Cells: Wistar Symposium Series (Book)
N1 - Accession Number: 28051182; Yarosh, Daniel B. 1; Affiliations: 1 : National Cancer Institute, NIH Building 37, Room 3c21, Bethesda, MD 20205; Source Info: Jun1981, Vol. 31 Issue 6, p458; Subject Term: Macromolecules; Subject Term: Nonfiction; Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 684
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Nagel, J. E.
AU - Chrest, F. J.
AU - Adler, W. H.
T1 - Human B cell function in normal individuals of various ages.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/06//
VL - 44
IS - 3
M3 - Article
SP - 646
EP - 653
PB - Wiley-Blackwell
SN - 00099104
AB - The effect of age on the in vitro generation of immunoglobulin-secreting cells in pokeweed mitogen-stimulated cultures was examined using a staphylococcal protein A plaque assay. Although there was no statistically significant decrease with age in the numbers of plaque-forming cells, subjects whose cells failed to produce immunoglobulin were four times more common amongst individuals over 55 years of age. Simultaneously-measured I and B lymphocyte numbers, 3H-thymidine incorporation by mitogen-stimulated cultures, and serum immunoglobulins were comparable in both the young and the aged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - IMMUNOGLOBULINS
KW - OLD age
KW - STAPHYLOCOCCAL protein A
KW - THYMIDINE
KW - PATIENTS
N1 - Accession Number: 16253473; Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.; Source Info: Jun1981, Vol. 44 Issue 3, p646; Subject Term: B cells; Subject Term: IMMUNOGLOBULINS; Subject Term: OLD age; Subject Term: STAPHYLOCOCCAL protein A; Subject Term: THYMIDINE; Subject Term: PATIENTS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baum, Bruce J.
T1 - Characteristics of participants in the oral physiology component of the Baltimore longitudinal study of aging.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1981/06//
VL - 9
IS - 3
M3 - Article
SP - 128
EP - 134
SN - 03015661
AB - This report describes a variety of demographic, socioeconomic and dental characteristics of 254 (145 male, 109 female) participants in a longitudinal study of oral physiology and aging. All individuals are part of the U.S. National Institute on Aging's Baltimore Longitudinal Study of Aging. Subjects are generally in middle to upper middle socioeconomic strata, well educated and in good health (about 75% not taking prescription medication). Most participants practice regular oral hygiene habits and receive regular and comprehensive dental care. Less than 4% of all subjects are edentulous and the average number of natural teeth present for all participants was about 23. Data are presented on DMFT scores, cervical caries (active and restored) scores and gingival and periodontal disease indices for males by age group (20-39, 40-59, 60-88 years) and for females by menopause status (pre-, post-). [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - GUM disease
KW - PERIODONTAL disease
KW - PERIODONTICS
KW - AGING
KW - TEETH -- Care & hygiene
KW - aging
KW - dental care
KW - dental status
KW - gingival disease
KW - oral physiology
KW - periodontal disease.
N1 - Accession Number: 12096155; Baum, Bruce J. 1; Affiliation: 1: Laboratory of Molecular Aging, Gerontology Research Center, national Institute of Aging, national Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland, U. S. A..; Source Info: Jun1981, Vol. 9 Issue 3, p128; Subject Term: DENTAL care; Subject Term: GUM disease; Subject Term: PERIODONTAL disease; Subject Term: PERIODONTICS; Subject Term: AGING; Subject Term: TEETH -- Care & hygiene; Author-Supplied Keyword: aging; Author-Supplied Keyword: dental care; Author-Supplied Keyword: dental status; Author-Supplied Keyword: gingival disease; Author-Supplied Keyword: oral physiology; Author-Supplied Keyword: periodontal disease.; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0528.ep12096155
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tweed, Dan L.
AU - Jackson, David J.
T1 - Psychiatric Disorder and Gender: A Logit Analysis.
JO - Social Forces
JF - Social Forces
Y1 - 1981/06//
VL - 59
IS - 4
M3 - Article
SP - 1200
EP - 1216
PB - Oxford University Press / USA
SN - 00377732
N1 - Accession Number: 5293490; Tweed, Dan L. 1 Jackson, David J. 2; Affiliation: 1: University of Maryland. 2: Mental Health Study Center, National Institute of Mental Health.; Source Info: Jun81, Vol. 59 Issue 4, p1200; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06549-002
AN - 2006-06549-002
AU - Zahn, Theodore P.
T1 - Environmental and Life Stress.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1981/06//
VL - 26
IS - 6
SP - 423
EP - 424
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06549-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Coping Behavior; Environmental Stress; Life Experiences. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Sarason, Irwin G. (Ed); Spielberger, Charles D. (Ed). Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology=Washington, D.C.: Hemisphere, 1979 399 pp $22 00; 1979. Page Count: 2. Issue Publication Date: Jun, 1981.
AB - Reviews the book, Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology edited by Irwin G. Sarason and Charles D. Spielberger (1979). The present volume has two rather definite focuses: environmental stress and life-event stress. The papers, with one exception, grew out of an Advanced Study Institute-held in Cambridge, England, in 1978 and sponsored by NATO-and represent contributions from Western Europe, Britain, Canada, and the United States. Most of them, like the NATO budget, come from the lastnamed country. An excellent chapter in this section by Stokols comes the closest of any to presenting a theoretical treatment of stress that would encompass both environmental and life stress. Stokols defines stress as 'a state of imbalance within an organism that is elicited by an actual or perceived disparity between environmental demands and the organism's capacity to cope with these demands. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - life-event stress
KW - environmental stress
KW - anxiety
KW - 1981
KW - Anxiety
KW - Coping Behavior
KW - Environmental Stress
KW - Life Experiences
KW - 1981
U2 - Sarason, Irwin G. (Ed); Spielberger, Charles D. (Ed). (1979); Stress and Anxiety, Vol. 6: The Series in Clinical and Community Psychology; Washington, D.C.: Hemisphere, 1979 399 pp $22 00
DO - 10.1037/020244
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - O'BRIEN, STEPHEN J.
T1 - Owl Monkey Cell Line.
JO - Science
JF - Science
Y1 - 1981/06/12/
VL - 212
IS - 4500
M3 - Article
SP - 1214
EP - 1214
SN - 00368075
N1 - Accession Number: 88003486; O'BRIEN, STEPHEN J. 1; Affiliations: 1: Genetics Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 6/12/1981, Vol. 212 Issue 4500, p1214; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FEDER, RALPH
AU - COSTA, JONATHAN L.
AU - CHAUDHARI, PRAVEEN
AU - SAYRE, DAVID
T1 - Improved Detail in Biological Soft X-ray Microscopy: Study of Blood Platelets.
JO - Science
JF - Science
Y1 - 1981/06/19/
VL - 212
IS - 4501
M3 - Article
SP - 1398
EP - 1400
SN - 00368075
AB - Improved image quality in soft x-ray contact microscopy can be obtained by examining the resist with transmission rather than scanning electron microscopy. Application of the new technique to air-dried preparations of human blood platelets reveals structures not visible in the satne cells with transmission electron microscopy or when the resist is examined by scanning electron microscopy. As seen by the new technique, platelet pseudopods contain a central structure connected to a network in the platelet and dense bodies exhibit a lamellar structure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84714164; FEDER, RALPH 1; COSTA, JONATHAN L. 2; CHAUDHARI, PRAVEEN 3; SAYRE, DAVID 3; Affiliations: 1: IBM Watson Research Center, Yorktown Heights, New York, 10598; 2: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, 20205; 3: IBM, Watson Research Center; Issue Info: 6/19/1981, Vol. 212 Issue 4501, p1398; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARRETT, J. CARL
AU - WONG, ANNETTE
AU - MCLACHLAN, JOHN A.
T1 - Diethylstilbestrol Induces Neoplastic Transformation Without Measurable Gene Mutation at Two Loci.
JO - Science
JF - Science
Y1 - 1981/06/19/
VL - 212
IS - 4501
M3 - Article
SP - 1402
EP - 1404
SN - 00368075
AB - The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84714166; BARRETT, J. CARL 1; WONG, ANNETTE 2; MCLACHLAN, JOHN A. 2; Affiliations: 1: Environmental Carcinogenesis Group, Laboratory of Pulmonary Function and Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709; 2: Transplacental Toxicology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences; Issue Info: 6/19/1981, Vol. 212 Issue 4501, p1402; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moment, Gairdner B.
T1 - "CLINICAL" GERONTOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1981/07//Jul/Aug1981
VL - 31
IS - 7
M3 - Book Review
SP - 540
EP - 540
SN - 00063568
AB - The article reviews the book "Aging--Its Chemistry: Proceedings of the Third Arnold O. Beckman Conference in Clinical Chemistry," edited by Albert A. Dietz.
KW - Aging
KW - Nonfiction
KW - Dietz, Albert A.
KW - Aging: Its Chemistry: Proceedings of the Third Arnold O. Beckman Conference in Clinical Chemistry (Book)
N1 - Accession Number: 28051228; Moment, Gairdner B. 1; Affiliations: 1 : Gerontology Research Center, National Institute on Aging Baltimore, MD 21224; Source Info: Jul/Aug1981, Vol. 31 Issue 7, p540; Subject Term: Aging; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 596
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DP - EBSCOhost
DB - 8gh
ER -
TY - GEN
AU - Chang, Ernest
AU - Ricart, Glenn
AU - Agrawala, Ashok K.
T1 - technical correspondence.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1981/07//
VL - 24
IS - 7
M3 - Letter
SP - 468
EP - 469
SN - 00010782
AB - A letter to the editor in response to the article "An Optimal Algorithm for Mutual Exclusion in Computer Networks," by G. Ricart and A. K. Agrawala in the January 181 issue is presented.
KW - LETTERS to the editor
KW - COMPUTER networks
N1 - Accession Number: 17854151; Chang, Ernest 1 Ricart, Glenn 2 Agrawala, Ashok K. 3; Affiliation: 1: University of Victoria, Victoria, B.C., Canada V8W 2Y2 2: National Institutes of Health, Bethesda, MD 20205 3: University of Maryland, College Park, MD 20742; Source Info: Jul1981, Vol. 24 Issue 7, p468; Subject Term: LETTERS to the editor; Subject Term: COMPUTER networks; NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42918-004
AN - 2013-42918-004
AU - Shore, Milton F.
T1 - Marking time in the land of plenty: Reflections on mental health in the United States.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1981/07//
VL - 51
IS - 3
SP - 391
EP - 402
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Shore, Milton F., Mental Health Study Center, National Institute of Mental Health, 2340 University Blvd. East, Adelphi, MD, US, 20783
N1 - Accession Number: 2013-42918-004. PMID: 7258305 Partial author list: First Author & Affiliation: Shore, Milton F.; Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Centers; Government Policy Making; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 12. Issue Publication Date: Jul, 1981. Copyright Statement: American Orthopsychiatric Association, Inc. 1981.
AB - This article focuses on reflections on mental health in the United States. This accumulation of wisdom and knowledge from experts inside and outside government has for the most part been ignored or shelved over the years because of revisions, deferrals, impoundments, vetoes, threatened vetoes, reorganizations, budget cuts, inflation, and military demands. Programs such as Head Start, which have been proven successful, have been fighting for survival, and community mental health centers, which in many ways represented a bold, new approach with much creative promise, were threatened with the loss of federal funding in the early 1970s. The humanist tradition in mental health and social services is best exemplified by Pinel's unchaining of psychotic patients: Itards infinite patience in working with Victor, the wild child: and Jane Addams's extraordinary development of community programs. On an international level a recent report of the WHO European Regional Office also has called for a wide ranging, independent group that would cut across national governments and exercise influence at high political levels to insure that important mental health policies are implemented. Perhaps the day will even come when an American President will feel responsible and accountable to the nation in an annual report to Congress and the people on the progress made in health and social welfare areas in his or her administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community programs
KW - humanist tradition
KW - mental health
KW - mental health policies
KW - 1981
KW - Community Mental Health Centers
KW - Government Policy Making
KW - Mental Health
KW - 1981
DO - 10.1111/j.1939-0025.1981.tb01388.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - WONG-STAAL, FLOSSIE
AU - DALLA-FAVERA, RICCARDO
AU - FRANCHINI, GENOVEFFA
AU - GELMANN, EDWARD P.
AU - GALLO, ROBERT C.
T1 - Three Distinct Genes in Human DNA Related to the Transforming Genes of Mammalian Sarcoma Retroviruses.
JO - Science
JF - Science
Y1 - 1981/07/10/
VL - 213
IS - 4504
M3 - Article
SP - 226
EP - 228
SN - 00368075
AB - Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain offeline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691502; WONG-STAAL, FLOSSIE 1; DALLA-FAVERA, RICCARDO 1; FRANCHINI, GENOVEFFA 1; GELMANN, EDWARD P. 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/10/1981, Vol. 213 Issue 4504, p226; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DA SILVA, PEDRO PINTO
AU - KACHAR, BECHARA
AU - TORRISI, MARIA ROSARIA
AU - BROWN, CHARLES
AU - PARKISON, CLIFFORD
T1 - Freeze-Fracture Cytochemistry: Replicas of Critical Point-Dried Cells and Tissues After Fracture-Label.
JO - Science
JF - Science
Y1 - 1981/07/10/
VL - 213
IS - 4504
M3 - Article
SP - 230
EP - 233
SN - 00368075
AB - Applications of the newfracture-labeling techniques for the observation of cytochemical labels on platinum-carbon replicas are described. Frozen cells, embedded in a cross-linked protein matrix, and frozen tissues are fractured with a scalpel under liquid nitrogen, thawed, labeled, dehydrated by the critical point drying method, and replicated. This method allows direct, high-resolution, twodimensional chemical and immunological characterization of the cellular membranes in situ, as well as detection of sites within cross-fractured cytoplasm and extracellular matrix. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691504; DA SILVA, PEDRO PINTO 1; KACHAR, BECHARA 1; TORRISI, MARIA ROSARIA 1; BROWN, CHARLES 1; PARKISON, CLIFFORD 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/10/1981, Vol. 213 Issue 4504, p230; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FRIEDMAN, ROBERT M.
T1 - Interferon and Interferon Inducers.
JO - Science
JF - Science
Y1 - 1981/07/17/
VL - 213
IS - 4505
M3 - Book Review
SP - 326
EP - 327
SN - 00368075
AB - A review of the book "Interferon and Interferon Inducers: Clinical Applications," by Dale A. Stringfellow is presented.
KW - Interferons
KW - Nonfiction
KW - Stringfellow, Dale A.
KW - Interferon & Interferon Inducers: Clinical Applications (Book)
N1 - Accession Number: 84691538; FRIEDMAN, ROBERT M. 1; Affiliations: 1: Laboratory of Experimental Pathology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/17/1981, Vol. 213 Issue 4505, p326; Subject Term: Interferons; Subject Term: Nonfiction; Reviews & Products: Interferon & Interferon Inducers: Clinical Applications (Book); People: Stringfellow, Dale A.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MARSHALL, K. C.
AU - PUN, R. Y. K.
AU - HENDELMAN, W. J.
AU - NELSON, P. G.
T1 - A Coeruleo-Spinal System in Culture.
JO - Science
JF - Science
Y1 - 1981/07/17/
VL - 213
IS - 4505
M3 - Article
SP - 355
EP - 357
SN - 00368075
AB - In combined cultures of dissociated spinal neurons and explants from the region of locus coeruleus, rich catecholamine-containing fiber projections from the explant to the surrounding regions of spinal neurons were demonstrated by fluorescence histochemistry. Electrical stimulation of the explant resulted in slow depolarizing responses in many of the spinal neurons. Cells exhibiting this type of response were also usually depolarized by local application of noradrenaline, whereas other, unresponsive neurons usually were not. The depolarizing responses to electrical stimulation and to noradrenaline were both increased by depolarizing current injection and decreased by hyperpolarizing current. These and other data suggest that the depolarizing responses of the spinal neurons to explant stimulation are mediated by noradrenaline released from axons of locus coeruleus neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Locus coeruleus
KW - Neurons -- Development
KW - Noradrenaline
KW - Catecholamines
KW - Neuromuscular depolarizing agents
KW - Axons
N1 - Accession Number: 84691555; MARSHALL, K. C. 1; PUN, R. Y. K. 2; HENDELMAN, W. J. 3; NELSON, P. G. 4; Affiliations: 1: Department of Physiology, University of Ottawa, Ottawa, Ontario, Canada KIN 9A9; 2: Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Anatomy, University of Ottawa; 4: Laboratory of Developmental Neurobiology, National Institutes of Health; Issue Info: 7/17/1981, Vol. 213 Issue 4505, p355; Thesaurus Term: RESEARCH; Subject Term: Locus coeruleus; Subject Term: Neurons -- Development; Subject Term: Noradrenaline; Subject Term: Catecholamines; Subject Term: Neuromuscular depolarizing agents; Subject Term: Axons; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MURPHY, MICHAEL R.
AU - MACLEAN, PAUL D.
AU - HAMILTON, SUE C.
T1 - Species-Typical Behavior of Hamsters Deprived from Birth of the Neocortex.
JO - Science
JF - Science
Y1 - 1981/07/24/
VL - 213
IS - 4506
M3 - Article
SP - 459
EP - 461
SN - 00368075
AB - Hamsters deprivedfrom birth of the neocortex developed normally and displayed the usual hamster-typical behavioral patterns. With the additional concurrent destruction of midline limbic convolutions (cingullate and underlying dorsal hippocampal), there were deficits in maternal behavior and a lack of development of play behavior. These findings demonstrate in a rodent (i) that the striatal complex and limbic system, along with the remaining neuraxis, are sufficient for giving expression to a wide range of unlearned forms of species-typical behavior and (ii) that midline limbic structures are required for the expression oj play behavior and the integrated performance of maternal behavior. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691600; MURPHY, MICHAEL R. 1; MACLEAN, PAUL D. 1; HAMILTON, SUE C. 1; Affiliations: 1: Laboratory of Brain Evolution and Behavior, National Institute of Mental Health, Post Office Box 289, Poolesville, Maryland 20837; Issue Info: 7/24/1981, Vol. 213 Issue 4506, p459; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOFFER, J. A.
AU - O'DONOVAN, M. J.
AU - PRATT, C. A.
AU - LOEB, G. E.
T1 - Discharge Patterns of Hindlimb Motoneurons During Normal Cat Locomotion.
JO - Science
JF - Science
Y1 - 1981/07/24/
VL - 213
IS - 4506
M3 - Article
SP - 466
EP - 468
SN - 00368075
AB - Long-term recording from single lumbar motoneurons of intact cats revealed activation patterns fundamentally differentfrom those seen in decerebrate preparations. In intact cats, motoneuron bursts showed marked rate modulation without initial doublets. Each unit's frequencygram generally resembled the envelope of the gross electromyogram simultaneously recorded from the corresponding muscle. Average and peak discharge rates increasedforfaster gaits. These findings suggest that, in cat locomotion, rate modulation is a more important contributor to force regulation than was previously thought. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691604; HOFFER, J. A. 1; O'DONOVAN, M. J. 1; PRATT, C. A. 1; LOEB, G. E. 1; Affiliations: 1: Laboratory of Neural Control, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/24/1981, Vol. 213 Issue 4506, p466; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KACHAR, BECHARA
AU - DA SILVA, PEDRO PINTO
T1 - Rapid Massive Assembly of Tight Junction Strands.
JO - Science
JF - Science
Y1 - 1981/07/31/
VL - 213
IS - 4507
M3 - Article
SP - 541
EP - 544
SN - 00368075
AB - Incubation at 37°C of excised rat prostate tissue results in massive proliferative assembly of new tight junction strands along the entire length of the lateral plasma membranes of the columnar epithelial cells. The new tight junction elements are assembled within 5 minutes and have an average length six times that of those present in the apical tight junction band. Massive assembly occurs in the presence of protein synthesis inhibitors (cycloheximide) or of metabolic uncouplers (dinitrophenol). Thus, proliferative assembly of tight junction strands involves molecular reorganization from a pool of preexisting, probably membrane-associated, components. The fascia occludens and some examples of experimentally induced tight junction proliferation may reflect the massive emergence of tight junction strands when tissue is subjected to diverse stressful conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85464218; KACHAR, BECHARA 1; DA SILVA, PEDRO PINTO 1; Affiliations: 1: Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p541; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - UDEINYA, IROKA J.
AU - SCHMIDT, JOHN A.
AU - AIKAWA, MASAMICHI
AU - MILLER, LOUIS H.
AU - GREEN, IRA
T1 - Falciparum Malaria-Infected Erythrocytes Specifically Bind to Cultured Human Endothelial Cells.
JO - Science
JF - Science
Y1 - 1981/07/31/
VL - 213
IS - 4507
M3 - Article
SP - 555
EP - 557
SN - 00368075
AB - Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to culturedfibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, or components, in the knobs of the infected erythrocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85464224; UDEINYA, IROKA J. 1; SCHMIDT, JOHN A. 2; AIKAWA, MASAMICHI 3; MILLER, LOUIS H. 4; GREEN, IRA 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases; 3: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 64108; 4: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p555; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YONEDA, TOSHIYUKI
AU - PRATT, ROBERT M.
T1 - Mesenchymal Cells from the Human Embryonic Palate Are Highly Responsive to Epidermal Growth Factor.
JO - Science
JF - Science
Y1 - 1981/07/31/
VL - 213
IS - 4507
M3 - Article
SP - 563
EP - 565
SN - 00368075
AB - An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85464228; YONEDA, TOSHIYUKI 1; PRATT, ROBERT M. 1; Affiliations: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p563; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NAMBOODIRI, M. A. A.
AU - FAVILLA, J. T.
AU - KLEIN, D. C.
T1 - Pineal N-Acetyltransferase Is Inactivated by Disulfide-Containing Peptides: Insulin Is the Most Potent.
JO - Science
JF - Science
Y1 - 1981/07/31/
VL - 213
IS - 4507
M3 - Article
SP - 571
EP - 573
SN - 00368075
AB - Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85464232; NAMBOODIRI, M. A. A. 1; FAVILLA, J. T. 1; KLEIN, D. C. 1; Affiliations: 1: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 7/31/1981, Vol. 213 Issue 4507, p571; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAll, R.P.
AU - Strober, W.
AU - Katz, S.I.
AU - Lawley, T.J.
T1 - IgA-containing circulating immune complexes in gluten-sensitive enteropathy.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/08//
VL - 45
IS - 2
M3 - Article
SP - 234
EP - 239
PB - Wiley-Blackwell
SN - 00099104
AB - Since mucosal immune response involving IgA may be particularly important in the pathogenesis of gluten-sensitive enteropathy (GSE). We examined the sera of 22 patients with GSE for IgA-containing circulating immune complexes using a sensitive radioimmunoassay. The Raji cell assay for IgA-containing circulating immune complexes. The Raji cell assay for lgG-containing circulating immune complexes and the 125-Clq-binding assay were also used to measure IgG- or IgM-containing circulating immune complexes in these patients. Ten of 22 (45%) patients had IgA-containing circulating immune complexes, while II of 22 (50%) had lgG- or IgM-containing circulating immune complexes. Thirteen of 22 (59%) patients had circulating immune complexes detected by at least one of the assays used. Neither the presence nor level of immune complexes correlated with disease activity in any of the patients studied. Five patients, whose disease was well controlled on a gluten-free diet, were studied serially during dietary challenge with gluten. It was found that IgA-containing circulating immune complexes did not develop or increase in amount in the serum of these patients despite the induction of gastrointestinal symptoms. In addition, no significant change in lgG- or IgM- containing circulating immune complexes occurred in any of the challenged patients. No significant abnormalities of serum complement levels (C3, C4, factor B) were detected in any of the patients including those challenged with gluten. Sucrose density-gradient ultracentrifugation studies revealed that the IgA-containing circulating immune complexes had sedimentation characteristics between 9S and 13S. The presence of circulating immune complexes in only 59%, of patients with GSE, their lack of correlation with disease activity, and their failure to change during dietary gluten challenge suggests that circulating immune complexes do not play a primary role in the pathogenesis of GSE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - PLANT proteins
KW - DIET in disease
KW - BLOOD plasma
KW - DIET therapy
KW - GLUTEN-free diet
N1 - Accession Number: 15961755; HAll, R.P. 1 Strober, W. 2 Katz, S.I. 1 Lawley, T.J. 1; Affiliation: 1: Dermatology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2: Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Aug1981, Vol. 45 Issue 2, p234; Subject Term: IMMUNOGLOBULINS; Subject Term: PLANT proteins; Subject Term: DIET in disease; Subject Term: BLOOD plasma; Subject Term: DIET therapy; Subject Term: GLUTEN-free diet; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hook, W. A.
AU - Siraganian, R. P.
T1 - Influence of anions, cations and osmolarity on IgE-mediated histamine release from human basophils.
JO - Immunology
JF - Immunology
Y1 - 1981/08//
VL - 43
IS - 4
M3 - Article
SP - 723
EP - 731
PB - Wiley-Blackwell
SN - 00192805
AB - Allergen-activated human basophils require Ca2+ for the in vitro release of histamine. This study evaluated the importance of anions, cations and osmotic pressure on histamine release from human basophils. All media contained 1 mM Ca2+ and various salts or sugars were used to replace the NaCl-KCl of the control medium. Permeant anions supported release of histamine with the following order of activities:acetate->Br-,I-, >Cl-≫SO42-. When monovalent cations of the standard medium were replaced, RbCI, CsCI, KCl or NaCl gave results identical to the NaCl-KCl control medium; choline chloride usually enhanced while LiCI inhibited release. Finally, when sugar solutions were used to replace monovalent anions and cations of the standard medium: mannitol, lactose, sucrose, sorbitol, fructose and glucose each supported histamine release. Increasing the osmolarity of the medium by adding additional NaCl-KCl enhanced the ability of suboptimal concentrations of ragweed antigen E or anti-IgE to activate and to release histamine from leucocytes. The results indicate that histamine release from basophils requires only Ca2+ and do not support the 'chemiosmotic swelling' hypothesis of secretion for these cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIONS
KW - CATIONS
KW - IMMUNOGLOBULIN E
KW - HISTAMINE
KW - BASOPHILS
KW - CARBOHYDRATES
N1 - Accession Number: 13989833; Hook, W. A. 1 Siraganian, R. P. 1; Affiliation: 1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 43 Issue 4, p723; Subject Term: ANIONS; Subject Term: CATIONS; Subject Term: IMMUNOGLOBULIN E; Subject Term: HISTAMINE; Subject Term: BASOPHILS; Subject Term: CARBOHYDRATES; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamaki, Kunihiko
AU - Fujiwara, Hiromi
AU - Levy, Robert B.
AU - Shearer, Gene M.
AU - Katz, Stephen I.
T1 - Hapten Specific TNP-reactive Cytotoxic Effector Cells Using Epidermal Cells as Targets.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/08//
VL - 77
IS - 2
M3 - Article
SP - 225
EP - 229
SN - 0022202X
AB - Epidermal spongiosis, invasion of mononuclear cells into the epidermis, and epidermal cell destruction are regular findings in allergic contact dermatitis. The mechanism(s) by which these changes occur is not known. We have examined the possibility that some of the pathological changes observed in allergic contact dermatitis could be accounted for by invasion of the epidermis by cytotoxic effector cells which recognize hapten-modified self-antigens and therein cause epidermal cell destruction. C3H and BALB/c mice were sensitized by epicutaneously applied 7% trinitrochlorobenzene (TNCB). 14 days later spleen cells from these mice were stimulated in vitro to trinitrophenylated-(TNP-conjugated) syngeneic spleen cells and their responses were compared to the in vitro responses of spleen cells from unsensitized mice. After 5 days of culture, effector cell activity was assayed on 51Cr-labeled TNP-conjugated syngeneic epidermal cells and on unconjugated epidermal cells. Cytotoxic activity was detected in the spleens of both mouse strains, but was greater in the C3H than the BALB/c strain. The cytotoxic effector cell activity was hapten specific in that spleen cells from TNCB sensitized mice did not cause lysis of fluorescein isothiocyanate (FITC) conjugated epidermal cells and spleen cells from FITC sensitized mice did not cause lysis of TNP-conjugated epidermal cells. No significant cytotoxic activity was detected on unconjugated epidermal cells. These findings suggest that destruction of the epidermis in allergic contact dermatitis may be contributed to by sensitized cytotoxic effector cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - LYMPHOID tissue
KW - EPITHELIUM
KW - CELL-mediated cytotoxicity
KW - PATHOLOGY
KW - CHLOROBENZENE
N1 - Accession Number: 12480043; Tamaki, Kunihiko 1 Fujiwara, Hiromi 1 Levy, Robert B. 1 Shearer, Gene M. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology and Immunology Branches, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p225; Subject Term: SKIN -- Inflammation; Subject Term: LYMPHOID tissue; Subject Term: EPITHELIUM; Subject Term: CELL-mediated cytotoxicity; Subject Term: PATHOLOGY; Subject Term: CHLOROBENZENE; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12480043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12480043&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraemer, Kenneth H.
AU - Levis, William R.
AU - Cason, Joseph C.
AU - Tarone, Robert E.
T1 - Inhibition of Mixed Leukocyte Culture Reaction by 8-Methoxypsoralen and Long-wavelength Ultraviolet Radiation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/08//
VL - 77
IS - 2
M3 - Article
SP - 235
EP - 239
SN - 0022202X
AB - Psoriasis patients receiving therapy with oral 8-methoxypsoralen plus long-wavelength ultraviolet radiation have been reported to have diminished leukocyte DNA synthesis and immune reactivity. In order to quantitate the immunological effects of therapeutic concentrations of 8-methoxypsoralen plus long-wavelength ultraviolet radiation, we measured the mixed leukocyte culture reaction in vitro. Leukocytes treated with 8-methoxypsoralen were exposed to plate glass filtered ultraviolet radiation from a bank of "PUVA" fluorescent lamps. To evaluate the (two-way) mixed leukocyte reaction, treated leukocytes were mixed with untreated leukocytes from another donor in microtiter wells and tritiated thymidine incorporation was measured after 4 to 6 days. To measure stimulation or proliferation ability (one-way mixed leukocyte reactions), treated or untreated leukocytes were exposed to 2000 R X-radiation prior to mixing. Treatment of leukocytes with 8-methoxypsoralen (0.01, 0.1, or 1.0 μg/ml) followed by 7,000 to 87,000 J/m² long-wavelength ultraviolet radiation resulted in a dose dependent inhibition of mixed leukocyte culture reactivity. 0.1 μg/ml 8-methoxypsoralen plus 7,000 J/m² ultraviolet radiation resulted in a 48% reduction (p < 0.01) in mixed leukocyte reaction-induced tritiated thymidine incorporation in the two-way assay. 1 μg/ml 8-methoxypsoralen plus 87,000 J/m² ultraviolet radiation virtually abolished reactivity in the two-way mixed leukocyte reaction and in both one-way mixed leukocyte reactions. Exposure to 87,000 J/m² long wavelength ultraviolet radiation alone resulted in 45% inhibition (p < 0.01) of stimulation ability. These results indicate that therapeutic concentrations of 8-methoxypsoralen followed by exposure to long-wavelength ultraviolet radiation inhibited both the stimulating ability and the mixed leukocyte culture reaction-induced proliferation of peripheral blood leukocytes in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - PYRIMIDINE nucleotides
KW - SKIN diseases
KW - DNA synthesis
KW - THYMIDINE
KW - LEUCOCYTES
N1 - Accession Number: 12480072; Kraemer, Kenneth H. 1 Levis, William R. 2 Cason, Joseph C. 2 Tarone, Robert E. 3; Affiliation: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 3: Biometry Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p235; Subject Term: ULTRAVIOLET radiation; Subject Term: PYRIMIDINE nucleotides; Subject Term: SKIN diseases; Subject Term: DNA synthesis; Subject Term: THYMIDINE; Subject Term: LEUCOCYTES; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12480072
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Alvarez, Oscar M.
AU - Bere Jr., E. William
AU - Eaglstein, William H.
AU - Katz, Stephen I.
T1 - Detection of Basement Membrane Zone Antigens During Epidermal Wound Healing in Pigs.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/08//
VL - 77
IS - 2
M3 - Article
SP - 240
EP - 243
SN - 0022202X
AB - Bullous pemphigoid (BP) antigen, laminin, and type IV collagen, 3 distinct antigens of basement membrane, were studied by indirect immunofluorescence in the epidermal-dermal junction of re-epithelializing wounds. Partial thickness wounds were made with a dermatome in the skin of white Yorkshire pigs. After 2 or 3 days, the wound site and the surrounding normal skin were excised and cryostat sections were studied using BP sera as well as whole antisera and affinity purified antibodies to laminin and type IV collagen. Laminin and type IV collagen were detected in the basement membrane zone of normal epidermis and at the re-epithelializing epidermal-dermal junction for a variable distance into the healing wound but both were absent from the more distal migrating epidermis. In contrast, BP antigen extended from the basement membrane zone of normal skin throughout the entire epidermal-dermal junction of the wound as far as the distal tip of the migrating epidermis. These results suggest that in the re-epithelization of superficial wounds laminin and type IV collagen are not present in the initial epidermal-dermal interaction of the migrating epithelium but that BP antigen may be important in this early interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIUM
KW - IMMUNOGLOBULINS
KW - COLLAGEN
KW - WOUND healing
KW - IMMUNOFLUORESCENCE
KW - IMMUNITY
N1 - Accession Number: 12480082; Stanley, John R. 1,2 Alvarez, Oscar M. 3 Bere Jr., E. William 1 Eaglstein, William H. 3 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch of the National Cancer Institute, National of Health, Bethesda, Maryland. 2: Laboratory of Development Biology and Anomalies of the National Institute of Dental Research National of Health, Bethesda, Maryland. 3: Department of Dermatology, University of Miami, Miami, Florida, U.S.A.; Source Info: Aug81, Vol. 77 Issue 2, p240; Subject Term: EPITHELIUM; Subject Term: IMMUNOGLOBULINS; Subject Term: COLLAGEN; Subject Term: WOUND healing; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNITY; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12480082
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Epstein, David A.
AU - Czarniecki, Christine W.
AU - Jacobsen, Helmut
AU - Friedman, Robert M.
AU - Panet, Amos
T1 - A Mouse Cell Line which Is Unprotected by Interferon against Lytic Virus Infection, Lacks Ribonuclease F Activity.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/08/03/
VL - 118
IS - 1
M3 - Article
SP - 9
EP - 15
PB - Wiley-Blackwell
SN - 00142956
AB - Analyzes enzymatic pathways which are induced by interferon in a mouse cell line. Inhibition of Moloney murine leukemia virus production; Phosphorylation; Level of the oligoadenylate synthetase activity; Induction of protein kinase activity.
KW - ENZYMES
KW - INTERFERONS
KW - CELL lines
KW - MICE as laboratory animals
KW - MOUSE leukemia viruses
KW - PHOSPHORYLATION
N1 - Accession Number: 12269915; Epstein, David A. 1 Czarniecki, Christine W. 1 Jacobsen, Helmut 1 Friedman, Robert M. 1 Panet, Amos 1; Affiliation: 1: Laboratory of Experimental Pathology, National Institutes of Health, National Institute of Arthritis, Metabolic, Digestive Diseases, Bethesda, and The Department of Virology, The Hebrew University, Hadassah Medical School, Jerusalem; Source Info: 8/3/81, Vol. 118 Issue 1, p9; Subject Term: ENZYMES; Subject Term: INTERFERONS; Subject Term: CELL lines; Subject Term: MICE as laboratory animals; Subject Term: MOUSE leukemia viruses; Subject Term: PHOSPHORYLATION; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HARPER, R. M.
AU - LEAKE, B.
AU - HOFFMAN, H.
AU - WALTER, D. 0.
AU - HOPPENBROUWERS, T.
AU - HODGMAN, J.
AU - STERMAN, M. B.
T1 - Periodicity of Sleep States Is Altered in Infants at Risk for the Sudden Infant Death Syndrome.
JO - Science
JF - Science
Y1 - 1981/08/28/
VL - 213
IS - 4511
M3 - Article
SP - 1030
EP - 1032
SN - 00368075
AB - The normal succession of sleep and waking states through a night is disturbed in infants at risk for the sudden infant death syndrome. Compared with normal infants, siblings of the sudden infant death syndrome victims have longer intervals between active sleep epochs at particular times during the night in the newborn period and a decreased tendency to enter short waking periods at 2 and 3 months of age. The latterfinding is interpreted as an increased tendency to remain asleep, or a relative failure to arouse from sleep in infants at risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691786; HARPER, R. M. 1; LEAKE, B. 1; HOFFMAN, H. 2; WALTER, D. 0. 3; HOPPENBROUWERS, T. 4; HODGMAN, J. 4; STERMAN, M. B. 5; Affiliations: 1: Department of Anatomy and Brain Research Institute, University of California, Los Angeles 90024; 2: Biometry Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 3: Brain Research Institute, University of California; 4: Department of Pediatrics and Newborn Service, Los Angeles County- University of Southern California Medical Center, Los Angeles 90033; 5: Veterans Administration Medical Center, Sepulveda, California 91343; Issue Info: 8/28/1981, Vol. 213 Issue 4511, p1030; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Bowery, Thomas G.
T1 - RISK MONEY FOR RESEARCH.
JO - BioScience
JF - BioScience
Y1 - 1981/09//
VL - 31
IS - 8
M3 - Letter
SP - 556
EP - 557
SN - 00063568
AB - A letter to the editor is presented in response to the article "Opinion," by Gairdner B. Moment in the June 1981 issue.
KW - Letters to the editor
KW - Research grants
N1 - Accession Number: 28051236; Bowery, Thomas G. 1; Affiliations: 1 : Biomedical Research Support Program Division of Research Resources National Institutes of Health Bethesda, MD 20205; Source Info: Sep1981, Vol. 31 Issue 8, p556; Subject Term: Letters to the editor; Subject Term: Research grants; Number of Pages: 2p; Document Type: Letter; Full Text Word Count: 581
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Nagel, James E.
T1 - CELLULAR IMMUNOBIOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1981/09//
VL - 31
IS - 8
M3 - Book Review
SP - 610
EP - 610
SN - 00063568
AB - The article reviews the book "Regulatory T Lymphocytes," edited by Benvenuto Pernis and Henry J. Vogel.
KW - Lymphocytes
KW - Nonfiction
KW - Pernis, Benvenuto
KW - Vogel, Henry J.
KW - Regulatory T Lymphocytes (Book)
N1 - Accession Number: 28051259; Nagel, James E. 1; Affiliations: 1 : National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224; Source Info: Sep1981, Vol. 31 Issue 8, p610; Subject Term: Lymphocytes; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 470
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Glynn, Thomas J.
T1 - Psychological Sense of Community: Measurement and Application.
JO - Human Relations
JF - Human Relations
Y1 - 1981/09//
VL - 34
IS - 9
M3 - Article
SP - 789
SN - 00187267
AB - The development and testing of an Instrument designed to measure "psychological sense of community" (PSC) is described. A discussion of the historical background of the PSC concept is presented and results of the use of the instrument in three U. S. and Israeli communities are described. Specific attention is given to the relationship of PSC and the variables of community satisfaction and competence as well as to applications of the PSC instrument. Since results suggest that certain manipulable variables may be associated with PSC, and that PSC itself may have the properties of a construct, suggestions for further research, and the potential importance of PSC for community development and maintenance are given. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Relations is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY development
KW - SOCIAL planning
KW - SOCIAL sciences
KW - COMMUNITIES -- Psychological aspects
KW - ISRAEL
KW - UNITED States
N1 - Accession Number: 4978407; Glynn, Thomas J. 1; Affiliations: 1: National Institute on Drug Abuse, 5600 Fishers Lane, Rockville, Maryland 20857.; Issue Info: Sep81, Vol. 34 Issue 9, p789; Thesaurus Term: COMMUNITY development; Subject Term: SOCIAL planning; Subject Term: SOCIAL sciences; Subject Term: COMMUNITIES -- Psychological aspects; Subject: ISRAEL; Subject: UNITED States; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 30p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Macdermott, R. P.
AU - Kienker, Laura J.
AU - Vertovich, M. J.
AU - Muchmore, A. V.
T1 - Inhibition of spontaneous but not antibody-dependent cell-mediated cytotoxicity by simple sugars: evidence that endogenous lectins may mediate spontaneous cell-mediated cytotoxicity.
JO - Immunology
JF - Immunology
Y1 - 1981/09//
VL - 44
IS - 1
M3 - Article
SP - 143
EP - 152
PB - Wiley-Blackwell
SN - 00192805
AB - Using Chang and K-562 cell line cells as targets, we have observed that a number of sugars are capable of inhibiting spontaneous cell-mediated cytotoxicity (SCMC) but not antibody-dependent cell-mediated cytotoxicity (ADCC). The sugars D(-)ribose, β-gentiobiose, N-acetyl-D-galatosamine, and α-lactose all significantly inhibited SCMC of Chang and K-562 cell line cells. Because these same sugars caused no inhibition of ADCC against either Chang or K-562 cell line cells in assays run simultaneously, the results do not appear to be due to a non-specific toxic effect of the sugars against the effector cells. These studies add to the evidence that ADCC and SCMC are mediated by separate receptors. Furthermore, they provide evidence that endogenous lectin receptors or lectin-like molecules may be involved in the recognition and/or effector stages leading to SCMC. Thus, NK cells may recognize targets by virtue of receptors capable of interacting with monosaccharide, disaccharide, or oligosaccharide sequences present alone, as glycolipids, and/or as glycoproteins on the target cell surface. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBODY-dependent cell cytotoxicity
KW - CELL-mediated cytotoxicity
KW - CELL lines
KW - CELL culture
KW - CELLULAR immunity
N1 - Accession Number: 13958923; Macdermott, R. P. 1 Kienker, Laura J. 1 Vertovich, M. J. 1 Muchmore, A. V. 1; Affiliation: 1: Hughes Medical Research Institute and Division of Gastroenterology, Washington University Medical Center, St. Louis, Missouri and Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep81, Vol. 44 Issue 1, p143; Subject Term: ANTIBODY-dependent cell cytotoxicity; Subject Term: CELL-mediated cytotoxicity; Subject Term: CELL lines; Subject Term: CELL culture; Subject Term: CELLULAR immunity; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Paul J.
AU - Rae, Donald S.
AU - Manderscheid, Ronald W.
AU - Silbergeld, Sam
T1 - Approximating the Moments and Distribution of the Likelihood Ratio Statistic for Multinomial Goodness of Fit.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1981/09//
VL - 76
IS - 375
M3 - Article
SP - 737
SN - 01621459
AB - Approximations were derived for the mean and variance of G[sup 2], the likelihood ratio statistic for testing goodness of fit in a k cell multinomial distribution. These approximate moments, accurate to O(N[sup -3]), may be used in fitting the distribution of G[sup 2]. Extensive numerical studies of the exact and approximate distributions were performed in the special case of equiprobability. The asymptotic chi-squared distribution was found to fit poorly for k >/= 4. Satisfactory results were obtained using a multiplicative correction to the chi-squared fit. More sophisticated procedures using the beta distribution produced increased accuracy, but at the cost of excessive computational labor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APPROXIMATION theory
KW - ANALYSIS of variance
KW - DISTRIBUTION (Probability theory)
KW - STOCHASTIC convergence
KW - MATHEMATICAL analysis
KW - CHARACTERISTIC functions
KW - ASYMPTOTIC expansions
KW - GOODNESS-of-fit tests
KW - NUMERICAL analysis
KW - Asymptotic moment expansions
KW - Beta distribution
KW - Chi-squared distribution
KW - Entropy statistic
KW - Equiprobability
KW - Information statistic.
N1 - Accession Number: 4607877; Smith, Paul J. 1; Rae, Donald S. 2; Manderscheid, Ronald W. 3; Silbergeld, Sam 4; Affiliations: 1: Associate Professor, Department of Mathematics, University of Maryland, College Park, MD 20742.; 2: Mathematician, Division of Computer Systems, Alcohol, Drug Abuse, and Mental Health Administration, Rockville, MD 20857.; 3: Research Sociologist and Chief, Evaluation and Needs Assessment Section, Division of Biometry and Epidemiology, National Institute of Mental Health, Rockville, MD 20857; 4: Research Psychiatrist, Chief, Biopsychosocial Research Section, Mental Health Study Center, National Institute of Mental Health, Adeiphi, MD 20783.; Issue Info: Sep81, Vol. 76 Issue 375, p737; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: MATHEMATICAL analysis; Subject Term: CHARACTERISTIC functions; Subject Term: ASYMPTOTIC expansions; Subject Term: GOODNESS-of-fit tests; Subject Term: NUMERICAL analysis; Author-Supplied Keyword: Asymptotic moment expansions; Author-Supplied Keyword: Beta distribution; Author-Supplied Keyword: Chi-squared distribution; Author-Supplied Keyword: Entropy statistic; Author-Supplied Keyword: Equiprobability; Author-Supplied Keyword: Information statistic.; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Weinfeld, Morton
AU - Sigal, John J.
AU - Eaton, William W.
T1 - Long-Term Effects of the Holocaust on Selected Social Attitudes and Behaviors of Survivors: A Cautionary Note.
JO - Social Forces
JF - Social Forces
Y1 - 1981/09//
VL - 60
IS - 1
M3 - Article
SP - 1
EP - 19
SN - 00377732
AB - A random sample of Jewish survivors of the Holocaust in Montreal is compared with two Jewish control groups. Modest or insignificant differences were found on measures of perceived anti-Semitism, economic and political satisfaction, social segregation, economic achievement, and propensity to migrate from Quebec. The findings caution against overgeneralization of a clinical construct, the survivor syndrome, and point to the need for further research into the remarkable capacities of human beings to overcome the most severe forms of victimization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOLOCAUST (1939-1945)
KW - SOCIAL attitudes
KW - HOLOCAUST survivors
KW - ANTISEMITISM
KW - JEWS
KW - CONCENTRATION camps
KW - BEHAVIOR
KW - ATTITUDE (Psychology)
KW - MONTREAL (Quebec)
KW - QUEBEC (Province)
KW - CANADA
N1 - Accession Number: 5287345; Weinfeld, Morton 1; Sigal, John J. 2; Eaton, William W. 3; Affiliations: 1 : McGill University.; 2 : Sir Mortimer B. Davis-Jewish General Hospital, Montreal.; 3 : National Institute of Mental Health.; Source Info: Sep81, Vol. 60 Issue 1, p1; Historical Period: 1978; Subject Term: HOLOCAUST (1939-1945); Subject Term: SOCIAL attitudes; Subject Term: HOLOCAUST survivors; Subject Term: ANTISEMITISM; Subject Term: JEWS; Subject Term: CONCENTRATION camps; Subject Term: BEHAVIOR; Subject Term: ATTITUDE (Psychology); Subject: MONTREAL (Quebec); Subject: QUEBEC (Province); Subject: CANADA; Number of Pages: 19p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - KAPATOS, GREGORY
AU - KAUFMAN, SEYMOUR
AU - WELLER, JOAN L.
AU - KLEIN, DAVID C.
T1 - Biosynthesis of Biopterin: Adrenergic Cyclic Adenosine Monophosphate-Dependent Inhibition in the Pineal Gland.
JO - Science
JF - Science
Y1 - 1981/09/04/
VL - 213
IS - 4512
M3 - Article
SP - 1129
EP - 1131
SN - 00368075
AB - Pineal glands in organ culture synthesize and release biopterin and are able to maintain concentrations of biopterin occurring in vivo for up to 54 hours in vitro. The intracellular biopterin content is reduced 50 percent by treatment with 1- norepinephrine or cyclic adenosine monophosphate derivatives, but not by dnorepinephrine. This is an indication that biopterin levels are regulated by an adrenergic cyclic adenosine monophosphate-dependent mechanism. The decline in tissue biopterin content, produced mainly by inhibition of biosynthesis, is maximal at 6 hours and is not associated with either an increase in biopterin release or a shift in the reduction state of the biopterin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691831; KAPATOS, GREGORY 1; KAUFMAN, SEYMOUR 1; WELLER, JOAN L. 2; KLEIN, DAVID C. 2; Affiliations: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Neuroendocrinology Section, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 9/ 4/1981, Vol. 213 Issue 4512, p1129; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MONASTERIO, F. M. DE
AU - SCHEIN, S. J.
AU - MCCRANE, E. P.
T1 - Stainin of Blue-Sensitive Cones of the Macaque Retina by a Fluorescent Dye.
JO - Science
JF - Science
Y1 - 1981/09/11/
VL - 213
IS - 4513
M3 - Article
SP - 1278
EP - 1281
SN - 00368075
AB - Intravitreal injection of a fluorescent dye, Procion yellow, results in the complete and systematic staining of a cone population in the monkey retina. These cones form an approximately regular array whose separation varies with retinal eccentricity. They are absent in the very center of the fovea, and their density peaks at 1°. The distribution of stained cones resembles that reported for blue-sensitive cones of other primates and, consistent with such an identification, they are found with less incidence in species having lower concentrations of blue cones. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85483540; MONASTERIO, F. M. DE 1; SCHEIN, S. J. 1; MCCRANE, E. P. 1; Affiliations: 1: Section on Visual Processing, Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/11/1981, Vol. 213 Issue 4513, p1278; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TREISER, SUSAN L.
AU - CASCIO, CAREN S.
AU - O'DONOHUE, THOMAS L.
AU - THOA, NGUYEN B.
AU - JACOBOWITZ, DAVID M.
AU - KELLAR, KENNETH J.
T1 - Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus.
JO - Science
JF - Science
Y1 - 1981/09/25/
VL - 213
IS - 4515
M3 - Article
SP - 1529
EP - 1531
SN - 00368075
AB - The effects of long-term lithium administration on pre- and postsynaptic processes involved in serotonergic neurotransmission were measured in rat hippocampus and cerebral cortex. Long-term lithium administration increased both basal and potassium chloride-stimulated release of endogenous serotonin from the hippocampus but not from the cortex. Serotonergic receptor binding was reduced in the hippocampus but not in the cortex. These results suggest a mechanism by which lithium may stabilize serotonin neurotransmission. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85483628; TREISER, SUSAN L. 1; CASCIO, CAREN S. 1; O'DONOHUE, THOMAS L. 2; THOA, NGUYEN B. 2; JACOBOWITZ, DAVID M. 2; KELLAR, KENNETH J. 3; Affiliations: 1: Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C. 20007; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry; Issue Info: 9/25/1981, Vol. 213 Issue 4515, p1529; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nakao, Y.
AU - Matsumoto, H.
AU - Miyazaki, T.
AU - Watanabe, S.
AU - Masaoka, T.
AU - Takatsuki, K.
AU - Kishihara, M.
AU - Kobayashi, N.
AU - Hattori, M.
AU - Fujita, T.
T1 - Genetic and clinical studies of serum β2-microglobulin levels in haematological malignancies.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/10//
VL - 46
IS - 1
M3 - Article
SP - 134
EP - 141
PB - Wiley-Blackwell
SN - 00099104
AB - Sera from 244 patients with haematological malignancies were examined for β2-micro- globulin (β2m) levels. There were 142 leukaemias, 32 malignant lymphomas, three immunoblastic lymphomas, two pseudolymphomas and 65 multiple myelomas. Culture supernatants from various established cell lines were also tested. The phenotype facilitating β2m shedding from the cell surface appeared to be independent of the specific IgG heavy chain allotypes; however, a myeloma group with normal serum β2m levels showed a significant association with the specific Gm allotypes. The determination of serum β2m levels can provide valuable information on the proliferative stage of the disorders, the effectiveness of chemotherapy, and be a diagnostic aid for blastic crisis in chronic myelocytic leukaemias, and for subtyping lymphoid malignancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM
KW - LYMPHOMAS
KW - LYMPHOPROLIFERATIVE disorders
KW - MULTIPLE myeloma
KW - GENOTYPE-environment interaction
KW - CELL membranes
KW - DRUG therapy
N1 - Accession Number: 16011572; Nakao, Y. 1 Matsumoto, H. 2 Miyazaki, T. 2 Watanabe, S. 3 Masaoka, T. 4 Takatsuki, K. 5 Kishihara, M. 1 Kobayashi, N. 1 Hattori, M. 1 Fujita, T. 1; Affiliation: 1: Third Division, Department of Medicine, Kobe University School of Medicine, Chuoku, Kobe. 2: Department of Legal Medicine, Osaka Medical College, Osaka. 3: Department of Pathology, National Cancer Institute, Tokyo. 4: Department of Medicine, Center for Adult Diseases, Osaka. 5: First Division, Department of Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan.; Source Info: Oct1981, Vol. 46 Issue 1, p134; Subject Term: SERUM; Subject Term: LYMPHOMAS; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: MULTIPLE myeloma; Subject Term: GENOTYPE-environment interaction; Subject Term: CELL membranes; Subject Term: DRUG therapy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Small, Arnold C.
AU - Madero, James
AU - Gross, Howard
AU - Teagno, Lorie
AU - Leib, Jere
AU - Ebert, Michael
T1 - A COMPARATIVE ANALYSIS OF PRIMARY ANOREXICS AND SCHIZOPHRENICS ON THE MMPI.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1981/10//
VL - 37
IS - 4
M3 - Article
SP - 733
EP - 736
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article focuses on primary anorexics and schizophrenics on the MMPI. Although only a very small number of studies have described personality testing in primary anorexia nervosa (patients), they seem to suggest a deeper personality disturbance than commonly suggested by psychiatric interview. The study of the personality dimensions of anorexia nervosa and the nosological category to which it belongs has led to very little agreement among investigators. With regard to their overall MMPI profile, patients with PAN showed a wide diversity of traits that are characteristic of character, neurotic, psychotic, and psychosomatic disorders.
KW - PERSONALITY
KW - APPETITE loss
KW - MENTALLY ill
KW - PATIENTS
KW - SCHIZOPHRENICS
KW - APPETITE disorders
N1 - Accession Number: 15845840; Small, Arnold C. 1 Madero, James 2 Gross, Howard 2 Teagno, Lorie 3 Leib, Jere Ebert, Michael 4; Affiliation: 1: George Mason University and Family & Child Development Services, Woodbridge, Va. 2: National Institute of Mental Health Bethesda, Maryland. 3: University of Maryland College Park, Maryland. 4: National Institute of Mental Health.; Source Info: Oct1981, Vol. 37 Issue 4, p733; Subject Term: PERSONALITY; Subject Term: APPETITE loss; Subject Term: MENTALLY ill; Subject Term: PATIENTS; Subject Term: SCHIZOPHRENICS; Subject Term: APPETITE disorders; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gillaspie Jr., A. G.
AU - Thomas, C. A.
AU - Prescott, B.
T1 - Inhibition of Sugarcane Mosaic Virus Symptoms on Sorghum by Microbial and Plant Polysaccharides and Their Antigenic Relationship.
T2 - Hemmung des Zuckerrohrmosaikvirus in Sorghum durch Polysaccharide von Mikroorganismcn und höheren Pflanzen.
JO - Phytopathologische Zeitschrift
JF - Phytopathologische Zeitschrift
Y1 - 1981/10//
VL - 102
IS - 2
M3 - Article
SP - 107
EP - 113
PB - Wiley-Blackwell
SN - 00319481
AB - Polysaccharides from 23 bacterial, fungal, and higher plant sources were tested for inhibition of systemic development of sugarcane mosaic virus (SCMV) in sweet sorghum {Sorghum hicolor 'Rio'). Extracts from virus infected leaves were mixed with the polysaccharides and inoculated onto plants with an artist's airbrush. Polysaccharides from yeast cell walls and from Bacillus subtilis and Streptococcus pneumoniae Type III cell-free culture liquids inhibited SCMV-infection by 90-100% (symptom formation on treated plants compared with control plants inoculated only with SCMV) at concentrations as low as 250 μg/ml. The other polysaccharides inhibited infection by 29 % or less at concentrations as high as 2000 μg/ml. Although several of the plant and microbial polysaccharides tested are antigenically related, no relationship between inhibitory activity and antigenic properties was apparent. (English) [ABSTRACT FROM AUTHOR]
AB - Polysaccharide von 23 Bakterien, Pilzen und höheren Pflanzen wurden auf ihre Hemmung der systemischen Entwicklung des Zuckerrohrmosaikvirus (SCMV) in Sorghum hicolor 'Rio' geprüft. Extrakte von virusinfizierten Blättern wurden mit den Polysacchariden gemischt und mit einem Pinsel auf Pflanzen geimpft. Polysaccharide aus Hefezellwänden und zellfreien Kulturfiltraten von Bacillus suhtilis und Streptococcus pneumoniae Typ III hemmten die Infektion mit SCMV zu 90 bis 100 % bei Konzentrationen von 250 μg/ml. Die übrigen Polysaccharide hemmten die Infektion um 29 % oder weniger bel Konzentration von 2000 μg/ml. Mehrere Polysaccharide von Pflanzen und Mikroorganismen waren zwar antigenisch verwandt, doch wurde keine Beziehung zwischen Hemmwirkung und Antigeneigenschaften gefunden. (German) [ABSTRACT FROM AUTHOR]
AB - Copyright of Phytopathologische Zeitschrift is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Polysaccharides
KW - Sugarcane mosaic virus
KW - Sorgo
KW - Yeast
KW - Bacillus subtilis
KW - Streptococcus pneumoniae
N1 - Accession Number: 15556750; Gillaspie Jr., A. G. 1; Thomas, C. A. 1; Prescott, B. 1; Affiliations: 1: U. S. Department of Agriculture, Beltsville, Maryland, National Institutes of Health, Bethesda, Maryland.; Issue Info: 1981, Vol. 102 Issue 2, p107; Thesaurus Term: RESEARCH; Subject Term: Polysaccharides; Subject Term: Sugarcane mosaic virus; Subject Term: Sorgo; Subject Term: Yeast; Subject Term: Bacillus subtilis; Subject Term: Streptococcus pneumoniae; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1439-0434.ep15556750
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Emilson, C. G.
AU - Bowen, W. H.
AU - Robrish, S. A.
AU - Kemp, C. W.
T1 - Effect of the antibacterial agents octenidine and chlorhexidine on the plaque flora in primates.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1981/10//
VL - 89
IS - 5
M3 - Article
SP - 384
EP - 392
SN - 0029845X
AB - The effect of the antibacterial substance octenidine on plaque formation and on oral microflora in eight monkeys fed a sucrose diet was studied. Plaque was obtained from buccal tooth surfaces of premolars and first molars in two quadrants using a swab and a dental carver and examined using culture and fluorescent antibody procedures. A significant reduction in plaque score was observed on the buccal tooth surfaces after daily topical application of 1%, solutions of octenidine and chlorhexidine for 7 d; octenidine was more effective than chlorhexidine, Placebo treatment with water was without significant effect. Octenidine and chlorhexidine affected the plaque flora in a similar manner; the proportion of S. sanguis increased in relation to baseline levels while the population of Actinomyces, especially the group A. viscosus and. A. naeslundii, was markedly reduced. S. sanguis showed an inverse relationship to members of Actinomyces in response to the action of the antimicrobial agents. Both plaque sampling methods revealed similar changes in bacterial composition as a result of treatment. The data show that octenidine is an effective inhibitor of dental plaque and its antimicrobial and antiplaque properties make it worthy of further studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - ANTIBACTERIAL agents
KW - SUCROSE
KW - TEETH
KW - DENTISTRY
KW - ANTIBIOTICS
KW - antibacterial agents
KW - chlorhexidine
KW - dental plaque
KW - flora
KW - octenidine
KW - primates
N1 - Accession Number: 13198775; Emilson, C. G. 1 Bowen, W. H. 1 Robrish, S. A. 1 Kemp, C. W. 1; Affiliation: 1: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.; Source Info: 1981, Vol. 89 Issue 5, p384; Subject Term: ANTI-infective agents; Subject Term: ANTIBACTERIAL agents; Subject Term: SUCROSE; Subject Term: TEETH; Subject Term: DENTISTRY; Subject Term: ANTIBIOTICS; Author-Supplied Keyword: antibacterial agents; Author-Supplied Keyword: chlorhexidine; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: flora; Author-Supplied Keyword: octenidine; Author-Supplied Keyword: primates; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06557-004
AN - 2006-06557-004
AU - Yarrow, Leon J.
T1 - The Many Faces of Continuity.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1981/10//
VL - 26
IS - 10
SP - 746
EP - 747
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06557-004. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Yarrow, Leon J.; Child and Family Research Branch, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Central Nervous System; Health; Human Development; Motivation; Physical Development. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Reviewed Item: Brim, Orville G. Jr. (Ed); Kagan, Jerome (Ed). Constancy and Change in Human Development=Cambridge, Mass.: Harvard University Press, 1980 760 pp $27 50; 1980. Page Count: 2. Issue Publication Date: Oct, 1981.
AB - Reviews the book, Constancy and Change in Human Development by Orville G. Brim, Jr., and Jerome Kagan (Eds.) (1980). By presenting an interdisciplinary selection of topics, the editors have avoided a narrow view of the issues. Enriching the volume considerably are chapters on the central nervous system (Stein & Dawson), the endocrine system (Doering), physical health (Starneld & Pless), and physical growth (Garn). These chapters help drive home the point that the philosophical and methodological issues underlying consideration of constancy and change are not so vastly different in disciplines other than psychology and sociology. The chapters on physical health, physical growth, the central nervous system, and the endocrine system underscore the complex determinants of continuity and discontinuity, and point up the difficulties in defining the concept clearly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - central nervous system
KW - endocrine system
KW - human development
KW - physical health
KW - sociology
KW - 1981
KW - Central Nervous System
KW - Health
KW - Human Development
KW - Motivation
KW - Physical Development
KW - 1981
U2 - Brim, Orville G. Jr. (Ed); Kagan, Jerome (Ed). (1980); Constancy and Change in Human Development; Cambridge, Mass.: Harvard University Press, 1980 760 pp $27 50
DO - 10.1037/019681
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - CHO-CHUNG, YOON SANG
AU - CLAIR, TIMOTHY
AU - BODWIN, JEFFREY S.
AU - BERGHOFFER, BELA
T1 - Growth Arrest and Morphological Change of Human Breast Cancer Cells by Dibutyryl Cyclic AMP and L-Arginine.
JO - Science
JF - Science
Y1 - 1981/10/02/
VL - 214
IS - 4516
M3 - Article
SP - 77
EP - 79
SN - 00368075
AB - The growth in vitro of human breast cancer cells, line MCF-7, was inhibited by a daily supplement of L-arginine (1 milligram per milliliter). Arginine acted synergistically with dibutyryl adenosine 3',S'-monophosphate (cyclic AMP) (10-6 molar) to enhance the growth inhibitory effect: the cell replication ceased completely within 2 days after treatment. The growth arrest accompanied a change in cell morphology and was preceded by increases in the cellular concentration of cyclic AMP, adenylate cyclase, and type II cyclic AMP-dependent protein kinase activities as well as a decrease of estrogen binding activity. The results suggest that growth of human breast cancer cells i's subject to cyclic AMP-mediated regulation and that arginine may play a specific role in this process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691885; CHO-CHUNG, YOON SANG 1; CLAIR, TIMOTHY 1; BODWIN, JEFFREY S. 1; BERGHOFFER, BELA 1; Affiliations: 1: Cellular Biochemistry Section, Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p77; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SIRES, L. R.
AU - HRUBY, S.
AU - ALVORD JR., E. C.
AU - HELLSTROM, I.
AU - HELLSTROM, K.-E.
AU - KIES, M. W.
AU - MARTENSON, R.
AU - DEIBLER, G. E.
AU - BECKMAN, E. D.
AU - CASNELLIE, J. E.
T1 - Species Restrictions of a Monoclonal Antibody Reacting with Residues 130 to 137 in Encephalitogenic Myelin Basic Protein.
JO - Science
JF - Science
Y1 - 1981/10/02/
VL - 214
IS - 4516
M3 - Article
SP - 87
EP - 89
SN - 00368075
AB - A monoclonal antibody (immunoglobulin GJ) has been produced that reacts against myelin basic protein present in or extractedfrom the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691889; SIRES, L. R. 1; HRUBY, S. 1; ALVORD JR., E. C. 1; HELLSTROM, I. 2; HELLSTROM, K.-E. 2; KIES, M. W. 3; MARTENSON, R. 3; DEIBLER, G. E. 3; BECKMAN, E. D. 4; CASNELLIE, J. E. 4; Affiliations: 1: Laboratory of Neuropathology, University of Washington School of Medicine, Seattle 98195; 2: Division of Tumor Immunology, Fred Hutchinson Cancer Research Center, Seattle 98104; 3: Laboratory of Myelin Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; 4: Laboratory of Molecular Pharmacology, Howard Hughes Medical Institute, Seattle 98195; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p87; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DUMOUCHEL, WILLIAM H.
AU - DEDRICK, ROBERT L.
AU - RAABE, OTTO G.
T1 - Dose-Response Analyses of Bone Cancers from Radium.
JO - Science
JF - Science
Y1 - 1981/10/09/
VL - 214
IS - 4517
M3 - Article
SP - 206
EP - 208
SN - 00368075
N1 - Accession Number: 84691932; DUMOUCHEL, WILLIAM H. 1; DEDRICK, ROBERT L. 2; RAABE, OTTO G. 3; Affiliations: 1: Department of Mathematics, Massachusetts Institute of Technology, Cambridge 02139; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory for Energy-Related Health Research, University of California, Davis 95616; Issue Info: 10/ 9/1981, Vol. 214 Issue 4517, p206; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JOSEPH, J. A.
AU - ENGEL, B. T.
T1 - Instrumental Control of Cardioacceleration Induced by Central Electrical Stimulation.
JO - Science
JF - Science
Y1 - 1981/10/16/
VL - 214
IS - 4518
M3 - Article
SP - 341
EP - 343
SN - 00368075
AB - Each of four monkeys (Macaca mulatta) was operantly conditioned to slow and to speed heart rate through a shock-avoidance procedure. During these sessions, electrical brain stimulation that produced tachycardia and pressor responses was delivered on alternate, 64-second segments to one of several brain regions. All animals were able to attenuate the increases in heart rate produced by brain stimulation during the slowing sessions when posterior hypothalamic and striatal regions were stimulated but not when anterior hypothalamic or subthalamic areas were stimulated. During speeding or control sessions during which heart rate was monitored, brain stimulation continued to increase heart rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477583; JOSEPH, J. A. 1; ENGEL, B. T. 1; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Issue Info: 10/16/1981, Vol. 214 Issue 4518, p341; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - REDDY, E. PREMKUMAR
AU - SMITH, MARY JANE
AU - AARONSON, STUART A.
T1 - Complete Nucleotide Sequence and Organization of the Moloney Murine Sarcoma Virus Genome.
JO - Science
JF - Science
Y1 - 1981/10/23/
VL - 214
IS - 4519
M3 - Article
SP - 445
EP - 450
SN - 00368075
AB - The complete nucleotide sequence of a mammalian transforming retrovirus, Moloney murine sarcoma virus, has been determined. MSV, a recombinant virus derived of helper viral and cellular sequences, possesses termini resembling prokaryotic transposable elements. The viral genome has the coding capacity for the Moloney murine leukemia virus gag gene product and contains large deletions in pol and env genes. A large open reading frame encompassing its cell-derived sequences codes for its putative transforming protein. The nature of some of the important domains in the viral genome has been established, and their structure is discussed in relation to their function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691969; REDDY, E. PREMKUMAR 1; SMITH, MARY JANE 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/23/1981, Vol. 214 Issue 4519, p445; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pastan, Ira H.
AU - Willingham, Mark C.
T1 - Journey to the Center of the Cell: Role of the Receptosome.
JO - Science
JF - Science
Y1 - 1981/10/30/
VL - 214
IS - 4520
M3 - Article
SP - 504
EP - 509
SN - 00368075
N1 - Accession Number: 84706819; Pastan, Ira H. 1; Willingham, Mark C. 1; Affiliations: 1: laboratory of molecular biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p504; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEVIN, PHILIP
AU - JANDA, JEAN K.
AU - JOSEPH, JAMES A.
AU - INGRAM, DONALD K.
AU - ROTH, GEORGE S.
T1 - Dietary Restriction Retards the Age-Associated Loss of Rat Striatal Dopaminergic Receptors.
JO - Science
JF - Science
Y1 - 1981/10/30/
VL - 214
IS - 4520
M3 - Article
SP - 561
EP - 562
SN - 00368075
AB - In male Wistar rats subjected to dietary restriction by alternate days of feeding andfasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded. The mean survival time of the rats on the restricted diet was increased by approximately 40 percent compared to control rats given free access to food. Dopamine receptor concentrations in striata of 24-monthold rats that had been on a restricted diet since weaning were 50 percent higher than those of control animals of the same age, and essentially comparable to 3- to 6- month-old control rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84706844; LEVIN, PHILIP 1; JANDA, JEAN K. 1; JOSEPH, JAMES A. 1; INGRAM, DONALD K. 1; ROTH, GEORGE S. 1; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p561; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GOLDBERG, STEVEN R.
AU - SPEALMAN, ROGER D.
AU - GOLDBERG, DONNA M.
T1 - Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine.
JO - Science
JF - Science
Y1 - 1981/10/30/
VL - 214
IS - 4520
M3 - Article
SP - 573
EP - 575
SN - 00368075
AB - Squirrel monkeys pressed a lever at high rates under a second-order schedule of reinforcement in which lever pressing produced a brief visual stimulus that was occasionally contiguous with an intravenous injection of nicotine. The rate of lever pressing could be markedly reduced either by substituting saline for nicotine injections or by blocking the effects of nicotine with mecantylamine. The rate of lever pressing could also be reduced by eliminating the briefvisual stimulus. These results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84706850; GOLDBERG, STEVEN R. 1; SPEALMAN, ROGER D. 2; GOLDBERG, DONNA M. 2; Affiliations: 1: National Institute on Drug Abuse, Addiction Research Center, Post Office Box 5200, Baltimore, Maryland 21224; 2: Harvard Medical School and New England Regional Primate Research Center, Southborough, Massachusetts 01772; Issue Info: 10/30/1981, Vol. 214 Issue 4520, p573; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Deshazo, R. D.
AU - Ewel, Cynthia
AU - Londono, Sonnya
AU - Metzger, Z.
AU - Hoffeld, J. T.
AU - Oppenheim, J. J.
T1 - Evidence for the involvement of monocyte-derived toxic oxygen metabolites in the lymphocyte dysfunction of Hodgkin's disease.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1981/11//
VL - 46
IS - 2
M3 - Article
SP - 313
EP - 320
PB - Wiley-Blackwell
SN - 00099104
AB - This study was performed to see if adherent cell-derived toxic oxygen metabolites contribute to the suppression of mononuclear cell blastogenic responses in Hodgkin's disease. Peripheral blood mononuclear cells from 10 patients with Hodgkin's disease were stimulated in culture with the mitogen PHA in the presence of the prostaglandin inhibitor indomethacin and the antioxidants catalase or vitamin E. Patient lymphocytes showed significant increases in PHA-induced proliferation at all PHA doses when cultured with indomethacin. Further augmentation of lymphocyte proliferation was achieved with the addition of catalase or vitamin E to indomethacin in the culture system. The increases in proliferation seen on culture with these agents were greatest in patients with more depressed initial PHA responses. When adherent cells were removed before culture, the agents no longer facilitated increases in proliferation. These data suggest that abnormal lymphocyte proliferative responses seen in Hodgkin's disease may result in part from the excessive production of toxic oxygen metabolites as well as prostaglandins by adherent cell populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - METABOLITES
KW - LEUCOCYTES
KW - ISOPENTENOIDS
KW - HODGKIN'S disease
KW - PROSTAGLANDINS
N1 - Accession Number: 15955000; Deshazo, R. D. 1,2,3 Ewel, Cynthia 1,2,3 Londono, Sonnya 1,2,3 Metzger, Z. 1,2,3 Hoffeld, J. T. 1,2,3 Oppenheim, J. J. 1,2,3; Affiliation: 1: Clinical Immunology Section, Tulane University School of Medicine, New Orleans, Louisiana. 2: Laboratory of Experimental Immunology, Walter Reed Army Medical Center, Washington, DC. 3: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Nov1981, Vol. 46 Issue 2, p313; Subject Term: LYMPHOCYTES; Subject Term: METABOLITES; Subject Term: LEUCOCYTES; Subject Term: ISOPENTENOIDS; Subject Term: HODGKIN'S disease; Subject Term: PROSTAGLANDINS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06556-021
AN - 2006-06556-021
AU - Fox, Bernard H.
T1 - Childhood Cancer: A Discipline in its Infancy.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1981/11//
VL - 26
IS - 11
SP - 850
EP - 850
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06556-021. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Fox, Bernard H.; National Cancer Institute, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Psychology; Clinicians; Neoplasms; Psychodynamics. Classification: Cancer (3293); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Kellerman, Jonathan (Ed). Psychological Aspects of Childhood Cancer=Springfield, Ill.: Charles C. Thomas, 1980 333 pp $32.50; 1980. References Available: Y. Page Count: 1. Issue Publication Date: Nov, 1981.
AB - Reviews the book, Psychological Aspects of Childhood Cancer by Jonathan Kellerman (Ed ) (1980). This book of contributions to the psychological management of young cancer patients is a creditable effort in a relatively new field. Kellerman's objective in collecting these contributions was to 'provide a comprehensive and practical guide to the psychological management of children with cancer.' The two parts of this book-'Impact of Illness and Treatment' (about 60%) and 'Clinical Approaches'--are somewhat different from each other, the second section containing more focused management suggestions, as in McCue's excellent 'Preparing Children for Medical Procedures.' The insightful clinician can gain much from both sections. As for Kellerman's objectives, the book provided a reasonably comprehensive and fairly practical guide to the psychological management of children with cancer. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological management
KW - cancer patients
KW - children
KW - psychological aspects
KW - clinical psychology
KW - 1981
KW - Clinical Psychology
KW - Clinicians
KW - Neoplasms
KW - Psychodynamics
KW - 1981
U2 - Kellerman, Jonathan (Ed). (1980); Psychological Aspects of Childhood Cancer; Springfield, Ill.: Charles C. Thomas, 1980 333 pp $32.50
DO - 10.1037/019780
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-24299-001
AN - 2009-24299-001
AU - Schneider, Stanley F.
T1 - Where have all the students gone? Positions of psychologists trained in clinical/services programs.
T3 - Human Resources in Psychology
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1981/11//
VL - 36
IS - 11
SP - 1427
EP - 1449
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
AD - Schneider, Stanley F., National Institute of Mental Health, Psychology Education Branch, Division of Manpower and Training Programs, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2009-24299-001. PMID: 7325480 Partial author list: First Author & Affiliation: Schneider, Stanley F.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Geography; Graduate Psychology Education; Psychologists. Minor Descriptor: Clinical Psychology Graduate Training; Mental Health Services. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. References Available: Y. Page Count: 23. Issue Publication Date: Nov, 1981.
AB - This article presents a variety of findings derived from two outcome studies of psychologists who received their doctorates from clinical/services training programs supported by the National Institute of Mental Health in the years 1968-1980. Comparative data are presented regarding the initial positions and geographical distribution of graduates during this period. Despite some erosion in the market for academic faculty positions, the results show a consistent and extraordinary degree of employment consonant with training and virtually no unemployment. Two thirds of the graduates have jobs in a range of organized settings for service, and over 22% of the remainder are in academic or research positions. The most recent study enables analyses of certain factors influencing the initial location of graduates. Particular attention is paid to three topics of national concern. Criteria are developed for designating rural/small town service providers, and evidence is presented showing that programmatic implementation of this priority in training yields results. The issue of clinical research is discussed; the scope of such research and the extent to which students may be engaged in it are examined. Data are provided on the recruitment of minority students, and factors affecting minority student retention and completion of training are discussed. Outcomes of master's-level training programs are presented separately, and characteristics of training at that level are contrasted with those in doctoral programs. In a concluding section, the findings are discussed in the context of changes in psychology graduate education during the past generation, some current value dilemmas that affect education are explored, and certain implications of the revised national policies for support of clinical training in mental health are reviewed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - current positions
KW - psychologists
KW - clinical/services training program doctorates
KW - geographical distribution
KW - 1981
KW - Employment Status
KW - Geography
KW - Graduate Psychology Education
KW - Psychologists
KW - Clinical Psychology Graduate Training
KW - Mental Health Services
KW - 1981
DO - 10.1037/0003-066X.36.11.1427
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Filer, David
AU - Dhar, Ravi
AU - Furano, Anthony V.
T1 - The Conservation of DNA Sequences over Very Long Periods of Evolutionary Time.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/11/02/
VL - 120
IS - 1
M3 - Article
SP - 69
EP - 77
PB - Wiley-Blackwell
SN - 00142956
AB - In the present study we tried to determine whether the presence of DNA sequences homologous to the Escherichia coli tuf gene (encodes peptide chain elongation factor Tu) in many taxonomically-unrelated prokaryotes is due to selective pressure for these sequences or due to the transfer of chromosomal material subsequent to the divergence of the genera from their progenitors. We found that the degree of sequence homology to the DNA immediately adjacent to the E. coli tuf A gene is either nonexistent or much less than that found for the tuf gene. Furthermore, the tuf-homologous sequences present in one prokaryote were found to be in large part the same as or a subset of those present in others. That is, various, prokaryotes share a common subset of tuf-homologous sequences. These findings suggest that strong selective pressure and not recent intergeneric chromosomal transfer is responsible for the ubiquitos presence of certain tuf-homologous sequences. Because the genetic code is degenerate, DNA sequence need not be conserved to conserve protein sequence. Therefore, if the only function of these sequences is to encode protein, their persistence must mean that in some instances codon sequence is selected for. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDE sequence
KW - ESCHERICHIA coli
KW - AMINO acid sequence
KW - BIOCHEMISTRY
KW - GENES
KW - PROKARYOTES
N1 - Accession Number: 13923268; Filer, David 1 Dhar, Ravi 1 Furano, Anthony V. 1; Affiliation: 1: Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, and Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 11/2/81, Vol. 120 Issue 1, p69; Subject Term: NUCLEOTIDE sequence; Subject Term: ESCHERICHIA coli; Subject Term: AMINO acid sequence; Subject Term: BIOCHEMISTRY; Subject Term: GENES; Subject Term: PROKARYOTES; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waxman, Phyllis G.
AU - Del Campo, Anthony A.
AU - Lowe, Michael C.
AU - Hamel, Ernest
T1 - Induction of Polymerization of Purified Tubulin by Sulfonate Buffers.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/11/02/
VL - 120
IS - 1
M3 - Article
SP - 129
EP - 136
PB - Wiley-Blackwell
SN - 00142956
AB - Interaction of both purified tubulin and microtubule protein (tubulin plus associated proteins) with two commonly used sulfonate buffers were examined. 1,4-Piperazineethanesulfonate (Pipes) and 4-morpholineethanesulfonate (Mes) at high concentrations induce the polymerization of purified tubulin in reactions requiring only buffer, tubulin and GTP. While both reactions were temperature-dependent, old, reversible and inhibited by GDP, colchicine or Ca2+, there were significant differences between them. Substantially lower tubulin and buffer concentrations were required for Pipes-induced polymerization; and turbidity was much more intense in the Pipes-induced than in the Mes-induced reaction at the same protein concentration Electron microscopy demonstrated that for the most part typical smooth-walled microtubules were formed in Mes, while aberrant forms were the predominant structures formed in Pipes. When the polymerization of microtubule protein was examined as a function of buffer concentration, biphasic patterns were observed with both Pipes and Mes; polymerization occurred at both low and high, but not intermediate, buffer concentrations. The turbidity observed at high concentrations of Pipes greatly exceeded that at low concentrations. With Mes, equivalent turbidity developed at both high and low buffer concentrations. Although associated proteins copolymerized with tubulin at low buffer concentrations, they were exclude from the polymerized material at high buffer concentrations. Pipes and Mes were compared to sodium phosphate, Tris/HCl and imidazole/HCl buffers at 0.1 M in several polymerization systems using both purified tubulin and microtubulate protein. The sulfonate buffers were invariably associated with more vigorous reactions than the other buffers. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBULINS
KW - POLYMERIZATION
KW - SULFONATES
KW - BIOCHEMISTRY
KW - CHEMICAL reactions
KW - MICROTUBULES
N1 - Accession Number: 13924015; Waxman, Phyllis G. 1 Del Campo, Anthony A. 1 Lowe, Michael C. 1 Hamel, Ernest 1; Affiliation: 1: Laboratory of Medicinal Chemistry and Biology and the Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 11/2/81, Vol. 120 Issue 1, p129; Subject Term: TUBULINS; Subject Term: POLYMERIZATION; Subject Term: SULFONATES; Subject Term: BIOCHEMISTRY; Subject Term: CHEMICAL reactions; Subject Term: MICROTUBULES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - LEVINE, ROBERT A.
AU - MILLER, LEONARD P.
AU - LOVENBERG, WALTER
T1 - Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis.
JO - Science
JF - Science
Y1 - 1981/11/20/
VL - 214
IS - 4523
M3 - Article
SP - 919
EP - 921
SN - 00368075
AB - The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84711984; LEVINE, ROBERT A. 1; MILLER, LEONARD P. 1; LOVENBERG, WALTER 1; Affiliations: 1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/20/1981, Vol. 214 Issue 4523, p919; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FISHMAN, MARK C.
AU - ZIMMERMAN, EARL A.
AU - SLATER, EVE E.
T1 - Renin and Angiotensin: The Complete System Within the Neuroblastoma x Glioma Cell.
JO - Science
JF - Science
Y1 - 1981/11/20/
VL - 214
IS - 4523
M3 - Article
SP - 921
EP - 923
SN - 00368075
AB - Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108- 15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum wvithdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84711985; FISHMAN, MARK C. 1; ZIMMERMAN, EARL A. 2; SLATER, EVE E. 3; Affiliations: 1: Laboratory of Developmental Biology, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032; 3: Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114; Issue Info: 11/20/1981, Vol. 214 Issue 4523, p921; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LOZOVSKY, DAVID
AU - SALLER, CHARLES F.
AU - KOPIN, IRWIN J.
T1 - Dopamine Receptor Binding Is Increased in Diabetic Rats.
JO - Science
JF - Science
Y1 - 1981/11/27/
VL - 214
IS - 4524
M3 - Article
SP - 1031
EP - 1033
SN - 00368075
AB - The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84706987; LOZOVSKY, DAVID 1; SALLER, CHARLES F. 1; KOPIN, IRWIN J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 11/27/1981, Vol. 214 Issue 4524, p1031; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DVORAK, JAMES A.
AU - CRANE, MARK ST. J.
T1 - Vertebrate Cell Cycle Modulates Infection by Protozoan Parasites.
JO - Science
JF - Science
Y1 - 1981/11/27/
VL - 214
IS - 4524
M3 - Article
SP - 1034
EP - 1036
SN - 00368075
AB - Synchronized HeLa cell populations were exposed to Trypanosoma cruzi or Toxoplasma gondii, obligate intracellular protozoan parasites that cause Chagas' disease and toxoplasmosis, respectively, in humans. The ability of the two parasites to infect HeLa cells increased as the HeLa cells proceeded from the GI phase to the S phase of their growth cycle and decreased as the cells entered G2-M. Characterization of the S-phase cell surface components responsible for this phenomenon could be beneficial in the development of vaccines against these parasitic diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84706989; DVORAK, JAMES A. 1; CRANE, MARK ST. J. 1; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/27/1981, Vol. 214 Issue 4524, p1034; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sondik, Edward J.
AU - Kristein, Marvin M.
T1 - Estimating Costs of Illness and Injuries: A Criticism.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/12//
VL - 71
IS - 12
M3 - Article
SP - 1392
EP - 1393
PB - American Public Health Association
SN - 00900036
AB - The article presents a criticism on an article by Hartunian, et. al. about estimating costs of injuries and illness. The authors reflect that the article presented a dichotomy of methodologies that could confuse lawmakers. They reflect that estimates of cost of illness is very critical in policy making of health issues and focus on methodologies of estimating cost of illness. They opine that the incidence approach and the prevalence approach suggested by Hartunian's group are both variants of the human capital approach and contend that both the prevalence approach and incidence approach are inappropriate or unsuitable when ongoing treatment costs is at issue. They suggest that the human capital method provides reasonable comparative estimates of the potential gains.
KW - HUMAN capital
KW - MEDICAL care costs
KW - MEDICAL economics
KW - CAPITATION fees (Medical care)
KW - HOSPITAL costs
KW - MEDICAL care
KW - MEDICAL care costs -- Law & legislation
KW - COST estimates
KW - MEDICAL laws & legislation
N1 - Accession Number: 4950375; Sondik, Edward J. 1 Kristein, Marvin M. 2; Affiliation: 1: Chief, Program Analysis and Evaluation Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20205 2: State University of New York, Stony Brook; Source Info: Dec1981, Vol. 71 Issue 12, p1392; Subject Term: HUMAN capital; Subject Term: MEDICAL care costs; Subject Term: MEDICAL economics; Subject Term: CAPITATION fees (Medical care); Subject Term: HOSPITAL costs; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs -- Law & legislation; Subject Term: COST estimates; Subject Term: MEDICAL laws & legislation; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Sondik, Edward
AU - Kristein, Marvin M.
T1 - A Rejoinder.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/12//
VL - 71
IS - 12
M3 - Letter
SP - 1408
EP - 1408
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Estimating Costs of Illness or Injuries," by Nelson S. Hartunian, et. al.
KW - LETTERS to the editor
KW - COST estimates
N1 - Accession Number: 4950449; Sondik, Edward 1 Kristein, Marvin M. 2; Affiliation: 1: Chief, Program Analysis and Evaluation Branch, MD 20205 2: Visiting Economist, National Heart, Lung, and Blood Institute Bethesda, MD 20205; Source Info: Dec1981, Vol. 71 Issue 12, p1408; Subject Term: LETTERS to the editor; Subject Term: COST estimates; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slomczynski, Kazimierz M.
AU - Miller, Joanne
AU - Kohn, Melvin L.
T1 - STRATIFICATION, WORK, AND VALUES: A POLISH-UNITED STATES COMPARISON.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1981/12//
VL - 46
IS - 6
M3 - Article
SP - 720
EP - 744
SN - 00031224
AB - In Poland and the United States social stratification is related to parental values and to social orientations, with men of higher position more likely to value self-direction and to have a social orientation consonant with valuing self-direction: a nonauthoritarian perspective, personally responsible standards of morality, and trustfulness. These relationships result in large measure from the greater opportunities afforded by higher position to be self-directed in one's work. In the United States, higher social-stratification position is associated with more favorable self-conceptions, largely as a result of the greater opportunities for occupational self-direction that higher position affords. In Poland, lower position is associated with greater self-confidence and less anxiety. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL stratification
KW - VALUES (Ethics)
KW - ETHICS
KW - SOCIAL status
KW - UNITED States
KW - POLAND
N1 - Accession Number: 14764181; Slomczynski, Kazimierz M. 1; Miller, Joanne 2; Kohn, Melvin L. 2; Affiliations: 1: University of Warsaw and National institute of Mental Health.; 2: National Institute of Mental Health.; Issue Info: Dec81, Vol. 46 Issue 6, p720; Subject Term: SOCIAL stratification; Subject Term: VALUES (Ethics); Subject Term: ETHICS; Subject Term: SOCIAL status; Subject: UNITED States; Subject: POLAND; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Kunz, Bernard A.
AU - Haynes, Robert H.
T1 - PHENOMENOLOGY AND GENETIC CONTROL OF MITOTIC RECOMBINATION IN YEAST.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1981/12//
VL - 15
M3 - Article
SP - 57
EP - 89
PB - Annual Reviews Inc.
SN - 00664197
AB - Examines the relations between DNA repair and recombination in yeast. Analysis of typical dose-response curves for ultraviolet light (UV)-induced gene conversion and mitotic crossing-over; Presentation of a list of mutations known to affect recombination in yeast.
KW - YEAST
KW - MITOSIS
KW - CELL cycle
KW - GENETIC recombination
KW - GENETICS
KW - CELL division (Biology)
N1 - Accession Number: 12347792; Kunz, Bernard A. 1 Haynes, Robert H. 2; Affiliation: 1: National Institute of Environmental Health Sciences, Laboratory of Molecular Genetics, North Carolina 2: Department of Biology, York University, Toronto, Ontario, Canada; Source Info: 1981, Vol. 15, p57; Subject Term: YEAST; Subject Term: MITOSIS; Subject Term: CELL cycle; Subject Term: GENETIC recombination; Subject Term: GENETICS; Subject Term: CELL division (Biology); NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 33p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nash, Howard A.
T1 - INTEGRATION AND EXCISION OF BACTERIOPHAGE λ THE MECHANISM OF CONSERVATIVE SITE SPECIFIC RECOMBINATION.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1981/12//
VL - 15
M3 - Article
SP - 143
EP - 167
PB - Annual Reviews Inc.
SN - 00664197
AB - Discusses the mechanism of conservative site-specific recombination in a bacteriophage lambda. Study of the integration/excision cycle of the bacteriophage; Organization of the studies around a model for integration and excision; Developments that elaborate the mechanism of the integration and excision reactions.
KW - BACTERIOPHAGES
KW - GENETIC recombination
KW - CHROMOSOMES
KW - BACTERIAL transformation
KW - GENETIC transformation
KW - GENETICS
N1 - Accession Number: 12347825; Nash, Howard A. 1; Affiliation: 1: Laboratory of Neurochemistry, National Institute of Mental Health Bethesda, Maryland; Source Info: 1981, Vol. 15, p143; Subject Term: BACTERIOPHAGES; Subject Term: GENETIC recombination; Subject Term: CHROMOSOMES; Subject Term: BACTERIAL transformation; Subject Term: GENETIC transformation; Subject Term: GENETICS; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Moment, Gairdner
T1 - EVOLUTION/CREATION DEBATE.
JO - BioScience
JF - BioScience
Y1 - 1981/12//
VL - 31
IS - 11
M3 - Letter
SP - 788
EP - 788
SN - 00063568
AB - A letter to the editor is presented in response to the article ""Evolution/Creation Debate: A Time For Truth," by R.C. Lewontin, previously published in the September 1981 issue of the periodical "BioScience."
KW - Evolution (Biology)
KW - Letters to the editor
N1 - Accession Number: 28051341; Moment, Gairdner 1; Affiliations: 1 : Professor of Biology Emeritus, Goucher College, Guest Scientist, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224; Source Info: Dec1981, Vol. 31 Issue 11, p788; Thesaurus Term: Evolution (Biology); Subject Term: Letters to the editor; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 441
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Emilson, C. G.
AU - Bowen, W. H.
T1 - Microbial analyses of dental plaque of monkeys (Macaca fascicularis) using fluorescent antibody techniques.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1981/12//
VL - 89
IS - 6
M3 - Article
SP - 458
EP - 462
SN - 0029845X
AB - Selected microbial components in supragingival dental plaque from recently captured monkeys were determined. Using specific fluorescent antibody (FA) conjugates S. sanguis was found to constitute an average of 11.8% of all cells. The population of Actinomyces accounted for 20.7% (range 5- 31) with A. viscosus and A. naeslundii as predominant species. Few lactobacilli were encountered. S. mutans was not detected in any specimens when examined by culture and FA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL plaque
KW - ACTINOMYCES
KW - IMMUNOGLOBULINS
KW - MONKEYS as laboratory animals
KW - CELL culture
KW - DIAGNOSTIC specimens
KW - dental plaque
KW - microbiology
KW - monkeys
KW - oral
N1 - Accession Number: 13200305; Emilson, C. G. 1 Bowen, W. H. 2; Affiliation: 1: Department of Cariology, Faculty of Odontology, University of Gothenburg, S-400 33 Gothenburg 33, Sweden. 2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, U.S.A.; Source Info: 1981, Vol. 89 Issue 6, p458; Subject Term: DENTAL plaque; Subject Term: ACTINOMYCES; Subject Term: IMMUNOGLOBULINS; Subject Term: MONKEYS as laboratory animals; Subject Term: CELL culture; Subject Term: DIAGNOSTIC specimens; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: microbiology; Author-Supplied Keyword: monkeys; Author-Supplied Keyword: oral; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHEN, YUAN-TSONG
AU - MATTISON, DONALD R.
AU - FEIGENBAUM, LIONEL
AU - FUKUI, HENRY
AU - SCHULMAN, JOSEPH D.
T1 - Reduction in Oocyte Number Following Prenatal Exposure to a Diet High in Galactose.
JO - Science
JF - Science
Y1 - 1981/12/04/
VL - 214
IS - 4525
M3 - Article
SP - 1145
EP - 1147
SN - 00368075
AB - When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the off spring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704820; CHEN, YUAN-TSONG 1,2; MATTISON, DONALD R. 1,2; FEIGENBAUM, LIONEL 1,2; FUKUI, HENRY 3; SCHULMAN, JOSEPH D. 1; Affiliations: 1: National Institute of Child Health and Human Development; 2: National Institutes of Health, Bethesda, Maryland 20205; 3: National Eye Institute, National Institutes of Health; Issue Info: 12/ 4/1981, Vol. 214 Issue 4525, p1145; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - POTTER, MICHAEL
T1 - Mammalian Genetics and Cancer.
JO - Science
JF - Science
Y1 - 1981/12/11/
VL - 214
IS - 4526
M3 - Article
SP - 1233
EP - 1234
SN - 00368075
N1 - Accession Number: 84704845; POTTER, MICHAEL 1; Affiliations: 1: Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1233; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GHISELLI, GIANCARLO
AU - SCHAEFER, ERNST J.
AU - GASCON, PEDRO
AU - BREWER JR., H. BRYAN
T1 - Type III Hyperlipoproteinemia Associated with Apolipoprotein E Deficiency.
JO - Science
JF - Science
Y1 - 1981/12/11/
VL - 214
IS - 4526
M3 - Article
SP - 1239
EP - 1241
SN - 00368075
AB - Subjects with type III hyperlipoproteinemia develop premature atherosclerosis and have hyperlipidemia due to an increase in cholesterol-rich very low density lipoproteins (VLDL) of abnormal electrophoretic mobility. Apolipoprotein E is a major protein constituent of VLDL and appears to be important for the hepatic uptake of triglyceride-rich lipoproteins. A new kindred of patients with type III hyperlipoproteinemia is described in which no plasma apolipoprotein E could be detected, consistent with the concept that type III hyperlipoproteinemia may be due to an absence or striking deficiency of apolipoprotein E. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704852; GHISELLI, GIANCARLO 1; SCHAEFER, ERNST J. 1; GASCON, PEDRO 1; BREWER JR., H. BRYAN 1; Affiliations: 1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1239; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MOODY, TERRY W.
AU - PERT, CANDACE B.
AU - GAZDAR, ADI F.
AU - CARNEY, DESMOND N.
AU - MINNA, JOHN D.
T1 - High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma.
JO - Science
JF - Science
Y1 - 1981/12/11/
VL - 214
IS - 4526
M3 - Article
SP - 1246
EP - 1248
SN - 00368075
AB - "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704855; MOODY, TERRY W. 1; PERT, CANDACE B. 2; GAZDAR, ADI F. 3; CARNEY, DESMOND N. 3; MINNA, JOHN D. 3; Affiliations: 1: Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037; 2: Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Medical Oncology Branch, National Cancer Institute, and National Naval Medical Center, Bethesda 20014; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1246; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TRAUGOTT, UTE
AU - SHEVACH, E.
AU - CHIBA, J.
AU - STONE, J. H.
AU - RAINE, C. S.
T1 - Autoimmune Encephalomyelitis: Simultaneous Identification of T and B Cells in the Target Organ.
JO - Science
JF - Science
Y1 - 1981/12/11/
VL - 214
IS - 4526
M3 - Article
SP - 1251
EP - 1253
SN - 00368075
AB - Monoclonal antibodies to guinea pig T cells and antibodies to guinea pig immunoglobulin G were used in immunofluorescence studies to identify T and B cells in central nervous system tissue from guinea pigs with acute autoimmune encephalomyelitis. T cells appeared before B cells and were distributed within the white matter parenchyma, while B cells remained in perivascular spaces. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704857; TRAUGOTT, UTE 1; SHEVACH, E. 2; CHIBA, J. 2; STONE, J. H. 2; RAINE, C. S. 3; Affiliations: 1: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461; 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Departments of Pathology (Neuropathology) and Neuroscience, and Rose F. Kennedy Center for Research, Mental Retardation and Human Development, Albert Einstein College of Medicine; Issue Info: 12/11/1981, Vol. 214 Issue 4526, p1251; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Marcus, Carol J.
AU - Laughlin, Catherine A.
AU - Carter, Barrie J.
T1 - Adeno-Associated Virus RNA Transcription in vivo.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1981/12/15/
VL - 121
IS - 1
M3 - Article
SP - 147
EP - 154
PB - Wiley-Blackwell
SN - 00142956
AB - We have studied RNA transcripts of the defective parvovirus, adeno-associated virus (AAV) present in poly-(A)rich and poly-(A)free fractions of nuclear and cytoplasmic RNA prepared from cells infected together with a helper adenovirus. Cytoplasmic poly-(A)rich RNA contains three overlapping spliced AAV RNAs having sizes of 3.9 × 103, 3.3 × 103 and 2.3 × 103 bases respectively. The nuclear precursors of these RNAs appear to be the coterminal unspliced poly(A)-rich RNAs containing 4.2 × 103, 3.6 × 103 and 2.6 × 103 bases respectively. These unspliced RNAs were also found in the cytoplasm. The nuclear poly(A)-free RNA contained a heterogenous population of AAV RNAs that were generally smaller than 2.3 × 103 bases. In addition, the Hirt pellet fraction of the nuclear RNA contained two discrete AAV poly(A)-free RNAs having sizes of 2.5 × 103 and 2.8 × 103 bases. The 4.2 × 103 and 3.6 × 103-base unspliced RNAs are more abundant than the coterminal 3.9 × 103 and 3.3 × 103-base spliced RNAs whereas the 2.3 × 103-base spliced RNA is much more abundant than the 2.6 × 103-base unspliced RNA. Thus, the cytoplasmic abundance of the AAV spliced RNAs appears to be controlled in part by the post-transcriptional events of splicing or message stability. We also analysed the effects of AAV defective-interfering genomes upon AAV transcription. These studies showed that when synthesis of standard AAV genomes was inhibited more than 10-fold by defective-interfering genomes there was no significant effect on the types or amounts of AAV RNA transcripts which accumulated. These observations indicate that interference by defective-interfering genomes occurs mostly at the level of DNA replication rather than transcription. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - PARVOVIRUSES
KW - DNA viruses
KW - CYTOPLASM
KW - RNA
KW - GENES
KW - DNA replication
N1 - Accession Number: 15800666; Marcus, Carol J. 1 Laughlin, Catherine A. 1 Carter, Barrie J. 1; Affiliation: 1: Laboratory of Experimental Pathology, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.; Source Info: 12/15/81, Vol. 121 Issue 1, p147; Subject Term: NUCLEIC acids; Subject Term: PARVOVIRUSES; Subject Term: DNA viruses; Subject Term: CYTOPLASM; Subject Term: RNA; Subject Term: GENES; Subject Term: DNA replication; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KNECHT, MICHAEL
AU - CATT, KEVIN J.
T1 - Gonadotropin-Releasing Hormone: Regulation of Adenosine 3',5'-.Monophosphate in Ovarian Granulosa Cells.
JO - Science
JF - Science
Y1 - 1981/12/18/
VL - 214
IS - 4527
M3 - Article
SP - 1346
EP - 1348
SN - 00368075
AB - The antigonadal effects of gonadotropin-releasing hormone in ovarian granulosa cells are due to attenuation of the adenosine 3',5'-monophosphate (cyclic AMP) response to follicle-stimulating hormone. Agonists of gonadotropin-releasing hormone progressively inhibit adenylate cyclase and stimulate phosphodiesterase activities in cultured granulosa cells, indicating that blockade of gonadotropin action is attributable to the combined effects of decreased production and increased degradation of cyclic AMP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345814; KNECHT, MICHAEL 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 12/18/1981, Vol. 214 Issue 4527, p1346; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FISHER, R. S.
AU - PERSSON, B.-E.
AU - SPRING, K. R.
T1 - Epithelial Cell Volume Regulation: Bicarbonate Dependence.
JO - Science
JF - Science
Y1 - 1981/12/18/
VL - 214
IS - 4527
M3 - Article
SP - 1357
EP - 1359
SN - 00368075
AB - When Necturus gallbladder epithelial cells are osmotically shrunken, they rapidly return to their original volume despite the continued presence of a hypertonic bathing solution. This volume-regulatoiy process requires bicarbonate ions in the bathing solutions and is associated with the uptake of chloride ions. Volume-regulatory increase by epithelial cells is probably due to the parallel operation of sodium-hydrogen and chloride-bicarbonate exchangers in the apical cell membrane. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85345819; FISHER, R. S. 1; PERSSON, B.-E. 1; SPRING, K. R. 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 12/18/1981, Vol. 214 Issue 4527, p1357; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-12929-000
AN - 9999-12929-000
AU - Cannon-Spoor, H. Eleanor
AU - Potkin, Steven G.
AU - Wyatt, Richard Jed
T1 - Premorbid Adjustment Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1982///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-12929-000. Acronyms: PAS. Partial author list: First Author & Affiliation: Cannon-Spoor, H. Eleanor; Saint Elizabeths Hospital, National Institute of Mental Health, Division of Special Mental Health Research, Adult Psychiatry Branch, Washington, District of Columbia, United States. Release Date: 20120709. Correction Date: 20160613. Instrument Type: Rating Scale. Test Format: Each section of the scale contains a number of items with a scoring range of 0-6. The '0' end of the continuum denotes the hypothetically healthiest end of the adjustment range, and the '6' the hypothetically least healthy end.. Language: English. Constructs: Developmental Goal Achievement; Premorbid Adjustment; Schizophrenia Onset; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Premorbid Adjustment Scale is to evaluate the degree of achievement of developmental goals at each of several periods of a subject's life before the onset of schizophrenia.
AB - Description: The Premorbid Adjustment Scale (PAS) was developed by Cannon-Spoor, Potkin, & Wyatt (1982). It is designed to evaluate the degree of achievement of developmental goals at each of several periods of a subject's life before the onset of schizophrenia. It evaluates the level of functioning in four major areas: social accessibility-isolation, peer relationships, ability to function outside the nuclear family, and capacity to form intimate socio-sexual ties. Items evaluating age-appropriate functioning in these areas are repeated for each period of the subject's life. The four life period sections are as follows: Childhood, up to 11 years; Early Adolescence, 12-15 years; Late Adolescence, 16-18 years; and Adulthood, 19 years and beyond. The final section, labeled General, is more global, containing items meant to estimate the highest level of functioning that the subject achieved before becoming ill, as well as the time span and characteristics of onset of illness, and general information such as amount of education. Scale items are made up of a combination of original, adopted, and modified items from the Phillips Scale, the Premorbid Social Adjustment Scale, and the Elgin Scale. Each section of the scale contains a number of items with a scoring range of 0-6. Psychometric properties of the scale were determined in several studies. The PAS appears to be useful in identifying patients likely to become chronically hospitalized or at high risk for readmission. It may also serve as a possible predictor of patients with brain abnormalities on a computerized tomography (CT) scan. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Premorbid Adjustment Scale
KW - Schizophrenia
KW - Functioning Level
KW - Patient History
KW - Test Development
KW - Test Reliability
KW - Test Validity
U5 - Premorbid Adjustment Scale (PAS) [Test Development]Measurement of premorbid adjustment in chronic schizophrenia. (AN: 1983-07993-001 from PsycINFO) Cannon-Spoor, H. Eleanor; Potkin, Steven G.; Wyatt, Richard J.; 1982. Source: Schizophrenia Bulletin. 8(3), National Institute of Mental Health, US; 1982; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Schizophrenic Patients; Normal Controls Keywords: Premorbid Adjustment Scale; Schizophrenia; Functioning Level; Patient History; Test Development; Test Reliability; Test Validity; Subjects: Ability Level; Adjustment; Patient History; Premorbidity; Schizophrenia; Test Construction; Test Reliability; Test Validity;
DO - 10.1037/t12929-000
L3 - Full; Full text; 999912929_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Wilson, Rickey
AU - Anderson, Larry J.
AU - Holman, Robert C.
AU - Gary, G. William
AU - Greenberg, Harry B.
T1 - Waterborne Gastroenteritis due to the Norwalk Agent: Clinical and Epidemiologic Investigation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/01//
VL - 72
IS - 1
M3 - Article
SP - 72
PB - American Public Health Association
SN - 00900036
AB - An outbreak of gastroenteritis occurred at it Pennsylvania summer camp in July 1978. Symptoms included abdominal pail (81 per cent), nausea (72 per cent), and vomiting (53 per cent): upper respiratory infection symptoms occurred in 35 per cent of the campers. Illness was associated with consumption of five or more glasses of water or water-containing beverages. Stool cultures from affected persons were negative for bacterial pathogens: however, a fourfold or greater rise to the Norwalk agent was demonstrated in serum samples of three ill persons tested and in none of eight controls (p < .02). Campers ill during the first session who were also present during the second session did not become ill during the second second session (p < .001). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY -- Research
KW - GASTROENTERITIS
KW - PATHOGENIC microorganisms
KW - CLINICAL medicine
KW - THERAPEUTICS
KW - DISEASES
KW - PUBLIC health
KW - HUMAN services
KW - PREVENTIVE medicine
KW - PENNSYLVANIA
N1 - Accession Number: 4949300; Wilson, Rickey 1 Anderson, Larry J. 2 Holman, Robert C. 2 Gary, G. William 3 Greenberg, Harry B. 4; Affiliation: 1: Department of Pediatrics, Texas Tech University, Regional Academic Health Sciences Center, 1400 Wallace Boulevard, Amarillo, TX 79106. 2: Viral Diseases Division, Bureau of Epidemiology, CDC. 3: Virology Division, Bureau of Laboratories, CDC. 4: National Institute of Allergy and Infectious Diseases, NIH, Bethesda.; Source Info: Jan1982, Vol. 72 Issue 1, p72; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: GASTROENTERITIS; Subject Term: PATHOGENIC microorganisms; Subject Term: CLINICAL medicine; Subject Term: THERAPEUTICS; Subject Term: DISEASES; Subject Term: PUBLIC health; Subject Term: HUMAN services; Subject Term: PREVENTIVE medicine; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barral-Netto, M.
AU - Hofstetter, M.
AU - Gustavo Dos Santos, J.
AU - Cheever, A. W.
AU - Ottesen, E. A.
T1 - Schistosoma mekongi infection in man: cellular immune responses and modulating mechanisms.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/01//
VL - 47
IS - 1
M3 - Article
SP - 65
EP - 73
PB - Wiley-Blackwell
SN - 00099104
AB - Cell-mediated immune responses (CMI), as assessed by lymphocyte proliferation in vitro. were evaluated in 11 Laotian patients harbouring asymptomatic chronic infections by Schistosoma mekongi, a schistosome closely related to S. japanicum. When the mononuclear cells of these patients were cultured in autologous plasma, lymphocyte responses to schistosome antigens were essentially nil, not differing from those of unexposed North American controls. Specific lymphocyte proliferation, however, was seen both after the removal of mononuclear cells that were nylon-wool-adherent and after substitution of the autologous serum in the culture with normal AB serum. Our data suggest that the CMI responses of humans with chronic S. mekongi infections are 'modulated' by adherent suppressor cells and serum-suppressive factors, and that modulation of CMI supports the stable host-parasite relationship in a similar fashion to that described for chronic human Schistosoma mansoni infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLULAR immunity
KW - LYMPHOCYTES
KW - BLOOD cells
KW - IMMUNE response
KW - SCHISTOSOMA
KW - CELL proliferation
N1 - Accession Number: 16344827; Barral-Netto, M. 1 Hofstetter, M. 1 Gustavo Dos Santos, J. 2 Cheever, A. W. 1 Ottesen, E. A. 1; Affiliation: 1: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland. 2: Medical College of Virginia, Richmond, Virginia, USA.; Source Info: Jan1982, Vol. 47 Issue 1, p65; Subject Term: CELLULAR immunity; Subject Term: LYMPHOCYTES; Subject Term: BLOOD cells; Subject Term: IMMUNE response; Subject Term: SCHISTOSOMA; Subject Term: CELL proliferation; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Agrawala, Ashok K.
AU - Tripathi, Satish K.
AU - Ricart, Glenn
T1 - Adaptive Routing Using a Virtual Waiting Time Technique.
JO - IEEE Transactions on Software Engineering
JF - IEEE Transactions on Software Engineering
Y1 - 1982/01//
VL - 8
IS - 1
M3 - Article
SP - 76
EP - 81
SN - 00985589
AB - The virtual waiting time technique is introduced as a solution to the problem of a controller distributing work to servers of different speeds. The servers are considered to be part of a distributed system without feedback. The virtual waiting time technique is shown to minimize the average completion time for a job distributed by the controller. The virtual waiting time technique does not depend on any arrival distribution and is applicable to any service time distribution. The performance of the technique is examined for different arrival and service time distributions. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Software Engineering is the property of IEEE Computer Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER systems
KW - DISTRIBUTED computing
KW - COMPUTER networks
KW - MULTIUSER computer systems
KW - COMPUTERS
KW - SOFTWARE engineering
KW - Load sharing
KW - routing
KW - virtual waiting time
N1 - Accession Number: 14385881; Agrawala, Ashok K. 1 Tripathi, Satish K. 1 Ricart, Glenn 2; Affiliation: 1: Department of Computer Science, University of Maryland, College Park, MD 2: Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD; Source Info: Jan82, Vol. 8 Issue 1, p76; Subject Term: COMPUTER systems; Subject Term: DISTRIBUTED computing; Subject Term: COMPUTER networks; Subject Term: MULTIUSER computer systems; Subject Term: COMPUTERS; Subject Term: SOFTWARE engineering; Author-Supplied Keyword: Load sharing; Author-Supplied Keyword: routing; Author-Supplied Keyword: virtual waiting time; NAICS/Industry Codes: 541512 Computer Systems Design Services; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 334111 Electronic Computer Manufacturing; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443142 Electronics Stores; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); Number of Pages: 6p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weiss, N.
AU - Hussain, R.
AU - Ottesen, E. A.
T1 - IgE antibodies are more species-specific than IgG antibodies in human onchocerciasis and lymphatic filariasis.
JO - Immunology
JF - Immunology
Y1 - 1982/01//
VL - 45
IS - 1
M3 - Article
SP - 129
EP - 137
PB - Wiley-Blackwell
SN - 00192805
AB - To explore the relative species specificities of the IgE and IgG antibody responses to helminth infections in man, we studied four pools of sera from patients infected with Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus or Ascaris lumbricoides and ten individual sera from patients with onchocerciasis. IgE antibodies were detected by radioallergosorbent test (RAST) analysis and IgO antibodies by a Staphylococcus protein A radioimmunoassay (Staph A-RIA). Analysis of the binding curves with four different immunosorbents (prepared from antigens of B. malayi, O. volvulus, Dipesalonema viteae and A. lwnbricoides) in the RAST and the binding curves with these same four antigens in the Staph A-RIA confirmed the relative species specificities for both the IgE and IgO antibody responses. Then determination of these antibody levels after specific absorption of the sera with both homologous and heterologous antigens showed that in all instances there was significantly less cross-reactivity with heterologous parasite antigens (i.e. higher species specificity) in the IgE antibody. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - FILARIASIS
KW - PATIENTS
KW - ANTIGENS
KW - SERUM
KW - PARASITES
N1 - Accession Number: 14175752; Weiss, N. 1 Hussain, R. 1 Ottesen, E. A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1982, Vol. 45 Issue 1, p129; Subject Term: IMMUNOGLOBULINS; Subject Term: FILARIASIS; Subject Term: PATIENTS; Subject Term: ANTIGENS; Subject Term: SERUM; Subject Term: PARASITES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rudorfer, Matthew V.
T1 - Cardiovascular Changes and Plasma Drug Levels after Amitriptyline Overdose.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1982/01//
VL - 19
IS - 1
M3 - Article
SP - 67
EP - 78
SN - 07313810
N1 - Accession Number: 79032066; Rudorfer, Matthew V. 1,2; Affiliations: 1: Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, 63110; 2: Pharmacological Sciences Program, National Institute of General Medical Sciences; and Clinical Psychobiology Branch National Institute of Mental Health, Bethesda, Maryland, 20205; Issue Info: 1982, Vol. 19 Issue 1, p67; Number of Pages: 12p; Document Type: Article
L3 - 10.3109/15563658208990367
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Whitehead, William E.
AU - Orr, William C.
AU - Engel, Bernard T.
AU - Schuster, Marvin M.
T1 - External Anal Sphincter Response to Rectal Distention: Learned Response or Reflex.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1982/01//
VL - 19
IS - 1
M3 - Article
SP - 57
EP - 62
SN - 00485772
AB - Three experiments were conducted to determine whether the external anal sphincter contraction which typically follows rectal distention is a reflex or a voluntary response. Experiment I compared 15 chronically constipated patients to 10 normal subjects. A reflex should be reliably elicited by its unconditional stimulus; but if this response is voluntary, chronically constipated patients would be less likely to show it because they have had fewer opportunities to practice it. Only half of chronically constipated patients showed the response compared to 100% of normals. Experiment II investigated whether the response is elicited by rectal distention during sleep in 10 healthy subjects. The response was significantly less likely to occur during sleep. Experiment III in 6 normal subjects revealed that this response can be voluntarily omitted. These experiments indicate that external anal sphincter contraction following rectal distention is a voluntary response, not a reflex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REFLEXES
KW - SPHINCTERS
KW - NEUROLOGIC examination
KW - CONSTIPATION
KW - DEFECATION disorders
KW - APPLIED psychology
N1 - Accession Number: 14179992; Whitehead, William E. 1,2 Orr, William C. 3 Engel, Bernard T. 4,5 Schuster, Marvin M. 6; Affiliation: 1: Department of Psychiatry, Johns Hopkins University School of Medicine, Gerontology Research Center (Baltimore). 2: National Institute on Aging, National Institute of Health, Department of Human Health Services, Bethesda, Baltimore City Hospitals. 3: Department of Clinical Physiology, Presbyterian Hospital, Oklahoma City, Oklahoma. 4: Gerontology Research Center (Baltimore), National Institute on Aging, National Institute of Health, Department of Human Health Services, Bethesda. 5: Baltimore City Hospitals. 6: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore City Hospitals.; Source Info: Jan1982, Vol. 19 Issue 1, p57; Subject Term: REFLEXES; Subject Term: SPHINCTERS; Subject Term: NEUROLOGIC examination; Subject Term: CONSTIPATION; Subject Term: DEFECATION disorders; Subject Term: APPLIED psychology; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-11812-001
AN - 2009-11812-001
AU - Brunstetter, Richard
T1 - Preface.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1982///
VL - 8
IS - 2
SP - 199
EP - 200
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-11812-001. Partial author list: First Author & Affiliation: Brunstetter, Richard; Center for Studies of Child and Adolescent Psychopathology, Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychopathology; Child Psychopathology; Schizophrenia. Minor Descriptor: Mental Health. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Page Count: 2. Issue Publication Date: 1982.
AB - The appearance of this issue of the Schizophrenia Bulletin marks an important phase in the development of the field of research in child and adolescent psychopathology. In its preparation, the Center for Studies of Schizophrenia has been joined by the Center for Studies of Child and Adolescent Psychopathology, which has recently been established in the Clinical Research Branch of the Division of Extramural Research Programs at the National Institute of Mental Health. Furthermore, this is the first time that an entire issue has been devoted to children and adolescents. From time to time over the years, important articles in this area for instance DeMyer, Hingtgen, and Jackson's review article on infantile autism (Vol. 7, No. 3, 1981) have appeared, but never before has the sense of growth in the field been such that it seemed warranted to devote a complete issue to what was happening in it. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - child psychopathology
KW - adolescent psychopathology
KW - 1982
KW - Adolescent Psychopathology
KW - Child Psychopathology
KW - Schizophrenia
KW - Mental Health
KW - 1982
DO - 10.1093/schbul/8.2.199
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Helmes, C. T.
AU - Atkinson, D. L.
AU - Jaffer, J.
AU - Sigman, C. C.
AU - Thompson, K. L.
AU - Kelsey, M. I.
AU - Kraybill, H. F.
AU - Munn, J. I.
T1 - Evaluation and classification of the potential carcinogenicity of organic air pollutants*.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/03/
VL - 17
IS - 3
M3 - Article
SP - 321
EP - 389
SN - 03601226
AB - Data on the carcinogenicity and Ames Salmonella test muta‐genicity were compiled for 671 organic chemicals reported to be potential air pollutants. Development of the data base entailed an evaluation of published reports of carcinogenicity and mutagenicity test results available in the open literature. Criteria were established for classifying the chemicals as recognized carcinogens, suspected carcinogens, tumor promoters or cocarcinogens, and mutagens or suspected mutagens. Confirmation of chemicals as ambient air pollutants was attempted only for the chemicals classified into a category of potential carcinogenicity other than unknown. Primary and secondary literature sources were searched for the reported detection of the chemicals as ambient air pollutants. This work resulted in the classification of 77 air pollutants as potential human carcinogens, as demonstrated by the categorization of 25 air pollutants as recognized carcinogens, 20 air pollutants as suspected carcinogens, 15 air pollutants as tumor promoters/cocarcinogens, and 50 air pollutants as mutagens or suspected mutagens. For 17 of the 50 air pollutants classified as mutagens or suspected mutagens, no adequate positive carcino‐genicity data were found. No evidence of mutagenicity determined by the Ames test was found for seven of the 25 recognized carcinogens or for nine of the 20 suspected carcinogens. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490486; Helmes, C. T. 1 Atkinson, D. L. 1 Jaffer, J. 1 Sigman, C. C. 1 Thompson, K. L. 1 Kelsey, M. I. 2 Kraybill, H. F. 2 Munn, J. I. 2; Affiliation: 1: SRI International, Menlo Park, CA, 94025 2: National Cancer Institute, Bethesda, MD, 20014; Source Info: Jan1982, Vol. 17 Issue 3, p321; Number of Pages: 69p; Document Type: Article
L3 - 10.1080/10934528209375038
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rogan, Walter
T1 - Exposure‐epidemiology: Novel approaches.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 457
EP - 461
SN - 03601226
AB - The proliferation of potentially toxic agents in the environment has caused suspicion that cancer, heart, lung, and other diseases will be produced. Epidemiologists seek associations between such agents and diseases with prevention in mind. Efficient use of established techniques of study and innovative new ones will be necessary for prevention to be achieved before obvious morbidity and mortality have taken place. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490493; Rogan, Walter 1; Affiliation: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709; Source Info: Jan1982, Vol. 17 Issue 4, p457; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/10934528209375045
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hayes, Howard M.
AU - Mason, Thomas J.
T1 - Some domesticated animals as sentinels of human disease.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 477
EP - 485
SN - 03601226
AB - The past use of animal models to denote hazards in man's environment is reviewed. Examples are presented of selected species with respect to their response to exposures from certain bacteria, viruses, parasites, mineral deficiencies, plant toxins, and man‐made substances analogous to the human experience. The importance of continued research in this field is emphasized in order to provide a clearer understanding of the effects of the ambient environment on present and subsequent human health. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490496; Hayes, Howard M. 1 Mason, Thomas J. 1; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p477; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/10934528209375048
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraybill, Herman F.
T1 - Multimedia exposure and concerns for a holistic approach toward assessment of risk for environmental carcinogens.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 491
EP - 497
SN - 03601226
AB - The necessity of studying man's interaction with his environment through multiple exposures to toxic agents is discussed in terms of a holistic approach to the study of environmental cancer. Six factors that should be considered in the elucidation of exposure/response relationships and risk analysis are set forth. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490498; Kraybill, Herman F. 1; Affiliation: 1: Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p491; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/10934528209375050
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lingeman, Carolyn H.
T1 - Human resources—measurement of environmental contaminants in post mortem sampling.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 515
EP - 518
SN - 03601226
AB - To properly evaluate the etiologic roles of environmental chemicals in chronic diseases such as cancer, arteriosclerosis, and fibrosing lung diseases, there is a need for an Environmental Tissue Pathology Repository with facilities for correlating environmental histories, pathologic lesions in tissues and levels of chemicals or particulate matter. The Armed Forces Institute of Pathology (AFIP) would be an appropriate location for such a facility. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490500; Lingeman, Carolyn H. 1,2; Affiliation: 1: National Cancer Institute, Bethesda, MD, 20205 2: The Armed Forces Institute of Pathology, Washington, D.C., 20306; Source Info: Jan1982, Vol. 17 Issue 4, p515; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/10934528209375052
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gillette, James R.
T1 - Problems in risk assessment.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 553
EP - 558
SN - 03601226
AB - Most quantitative risk assessments are based on the assumption that environmental chemicals cause the same toxicities in humans and laboratory animals in about the same concentrations. It is well known, however, that the assumption is invalid in most instances. What is needed is the development of a program of interrelated studies designed to elucidate active forms of the toxicant, the concentrations at which these forms cause the observed toxicities in different species and strains of animals and the factors that modify the manifestation and severity of the toxicities. Such knowledge should provide key clues for identifying sensitive human subpopulations. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490505; Gillette, James R. 1; Affiliation: 1: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p553; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/10934528209375057
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nebert, Daniel W.
T1 - The importance of genetics in the metabolism and fate of mutagens and promutagens.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 559
EP - 566
SN - 03601226
AB - Because of differences in gene expression and variability among the various test systems, extrapolation of mutagenesis data gained from nonhuman studies to predictability of mutagens in man is shown to be very difficult. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490506; Nebert, Daniel W. 1; Affiliation: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, Bethesda, MD, 20205; Source Info: Jan1982, Vol. 17 Issue 4, p559; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10934528209375058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chae, Kun
AU - Albro, Phillip W.
AU - McKinney, James D.
T1 - A new synthesis of tetrachlorofluorodibenzo‐ p ‐dioxin.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1982/01/05/
VL - 17
IS - 5
M3 - Article
SP - 441
EP - 445
SN - 03601234
AB - The 1,2,3,4‐tetrachloro‐7‐fluorodibenzo‐p‐dioxin has been synthesized via condensation of 4‐fluorocatechol and pentachloronitrobenzene. This compound could be used as an internal standard for the analysis of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin by Chromatographic methods. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75452674; Chae, Kun 1; Albro, Phillip W. 1; McKinney, James D. 1; Affiliations: 1: Laboratory of Environmental Chemistry, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709; Issue Info: Jan1982, Vol. 17 Issue 5, p441; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/03601238209372333
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Albro, Phillip W.
AU - Hass, J. Ronald
AU - Peck, Carl C.
AU - Jordan, Sandra T.
AU - Corbett, Jean T.
AU - Schroeder, Joanna
T1 - Applications of isotope differentiation for metabolic studies with di‐(2‐ethylhexyl) phthalate.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1982/01/06/
VL - 17
IS - 6
M3 - Article
SP - 701
EP - 714
SN - 03601234
AB - The pervasiveness of the plasticizer di‐(2‐ethylhexyl) phthalate (DEHP) in the environment and especially in the laboratory results in a background that may cause severe interference with analytical studies. Animal‐to‐animal variability in the distribution of DEHP metabolites in excreta normally makes it necessary to use large groups of animals when different treatments are compared. Finally, radioactive tracers are usually considered undesirable for metabolic studies involving human subjects. All of these problems can be overcome through the use of muliple isotopic labels, especially 12C/13C/14C. Examples are given involving rats and monkeys, and applicability to humans is discussed. The principles involved are not limited to any particular class of test compounds. In rats, the competing pathways for metabolism of phthalate esters produce a different distribution of metabolites from a small intravenous dose of DEHP than from a large oral dose. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75452708; Albro, Phillip W. 1; Hass, J. Ronald 1; Peck, Carl C. 2; Jordan, Sandra T. 1; Corbett, Jean T. 1; Schroeder, Joanna 1; Affiliations: 1: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709; 2: Uniformed Services, University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, 20014; Issue Info: Jan1982, Vol. 17 Issue 6, p701; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/03601238209372351
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WHANG-PENG, J.
AU - KAO-SHAN, C. S.
AU - LEE, E. C.
AU - BUNN, P. A.
AU - CARNEY, D. N.
AU - GAZDAR, A. F.
AU - MINNA, J. D.
T1 - Specific Chromosome Defect Associated with Human Small-Cell Lung Cancer: Deletion 3p(14-23).
JO - Science
JF - Science
Y1 - 1982/01/08/
VL - 215
IS - 4529
M3 - Article
SP - 181
EP - 182
SN - 00368075
AB - A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704900; WHANG-PENG, J. 1; KAO-SHAN, C. S. 1; LEE, E. C. 1; BUNN, P. A. 2; CARNEY, D. N. 2; GAZDAR, A. F. 2; MINNA, J. D. 2; Affiliations: 1: Medicine Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: NCI-VA Medical Oncology Branch, Division of Cancer Treatment, National Cancer Institute, and Washington VA Medical Center, Washington, D.C. 20422; Issue Info: 1/ 8/1982, Vol. 215 Issue 4529, p181; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MEYER, D. K.
AU - BEINFELD, M. C.
AU - OERTEL, W. H.
AU - BROWNSTEIN, M. J.
T1 - Origin of the Cholecystokinin-Containing Fibers in the Rat Caudatoputamen.
JO - Science
JF - Science
Y1 - 1982/01/08/
VL - 215
IS - 4529
M3 - Article
SP - 187
EP - 188
SN - 00368075
AB - Large amounts of cholecystokinin-octapeptide (CCK) are present in the rat caudatoputamen. The peptide occurs in axons and nerve endings but not in perikarya. The origin of CCK in the caudatoputamen was investigated with the use of immunocytochemistry and a radioimmunoassay specific for CCK. Although a small amount of CCK (approximately 30 percent) originates in the amygdaloid complex, the bulk of the peptide (approximately 70 percent) occurs in processes of neurons located ventral to the caudatoputamen, that is, the claustrum or the piriform cortex. The claustrum and piriform cortex receive inputs from various cortical areas and the olfactory system, respectively, and may process information and relay it to the caudatoputamen. Thus CCK may be the transmitter in the final common pathway linking various cortical areas and the olfactory system to the caudatoputamen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704903; MEYER, D. K. 1; BEINFELD, M. C. 1; OERTEL, W. H. 1; BROWNSTEIN, M. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/ 8/1982, Vol. 215 Issue 4529, p187; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lenk, Robert P.
AU - Maizel Jr., Jacob V.
AU - Crouch, Robert J.
T1 - Expression of Two Late Adenovirus Genes Is Altered by Introducing Antibodies against Ribonucleoprotein into Living HeLa Cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1982/01/15/
VL - 121
IS - 3
M3 - Article
SP - 475
EP - 482
PB - Wiley-Blackwell
SN - 00142956
AB - These experiments describe the effect on adenovirus gene expression of transfusing liposome-encapsulated antibodies directed against a 10-S ribonucleoprotein complex into infected Hela cells. Immunoprecipitation studies demonstrate that this particular serum contains antibodies directed against particles containing U 1 RNA and five polypeptides in the molecular weight range of 45000-60000. The procedure of fusing liposomes successfully treats nearly all the cells in culture, and the transfused material has access throughout the cell. The IgG fraction from this serum is introduced into adenovirus-infected cells shortly before the transition from the early to the fate stage of the lytic cycle; 19 h after fusion the accumulated effects of the antibodies on late virus expression are examined by pulse-labeling cells with radioactive methionine and observing the synthesized proteins. While most late viral genes are expressed normally in treated cells, fiber synthesis is reduced to a very low level and hexon synthesis is reduced twofold. That most viral genes are expressed normally demonstrates that many cell activities (transcription, transport, processing and translation) are minimally affected. The effects on these two genes can be distinguished by varying the concentration of antibody transfused: interference with hexon synthesis occurs at a lower dosage than fiber. A simple interpretation of these results is that the antibody has bound to its antigen and prevented the latter from participating in its role in message processing. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - CELLS
KW - IMMUNOGLOBULINS
KW - BLOOD plasma
KW - CLONE cells
KW - NUCLEIC acids
KW - HEREDITY
N1 - Accession Number: 15800496; Lenk, Robert P. 1 Maizel Jr., Jacob V. 1 Crouch, Robert J. 1; Affiliation: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 1/15/82, Vol. 121 Issue 3, p475; Subject Term: GENE expression; Subject Term: CELLS; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD plasma; Subject Term: CLONE cells; Subject Term: NUCLEIC acids; Subject Term: HEREDITY; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Milne, G. W. A.
AU - Fisk, C. L.
AU - Heller, Stephen R.
AU - Potenzone Jr., Rudolph
T1 - Environmental Uses of the NIHEPA Chemical Information System.
JO - Science
JF - Science
Y1 - 1982/01/22/
VL - 215
IS - 4531
M3 - Article
SP - 371
EP - 375
SN - 00368075
N1 - Accession Number: 88003537; Milne, G. W. A. 1; Fisk, C. L. 2; Heller, Stephen R. 3; Potenzone Jr., Rudolph 4; Affiliations: 1: Research chemist, National Cancer Institute, Bethesda, Maryland 20205; 2: Staff fellow, National Institutes of Health, Bethesda, Maryland 20205; 3: Physical scientist, Management Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; 4: Systems analyst, Management Information Data Systems Division, Environmental Protection Agency, Washington, D.C. 20460; Issue Info: 1/22/1982, Vol. 215 Issue 4531, p371; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Patrick, Clifford H.
AU - Palesch, Yuko Y.
AU - Feinleib, Manning
AU - Brody, Jacob A.
T1 - Sex Differences in Declining Cohort Death Rates From Heart Disease.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/02//
VL - 72
IS - 2
M3 - Article
SP - 161
PB - American Public Health Association
SN - 00900036
AB - We examined cohort mortality from heart disease (HD) at ages 40 and over for White men and women in the United States between 1945 and 1975. For each successive birth cohort from 1886 to 1890 and 1906 to 1910, female HD mortality rates exhibit a continuous decline with parallel slopes which shows no sign of abating in recent years. Among men, cohort HD mortality rates were increasing prior to 1965: since 1965, there has been a reversal of prior trends, i.e., each successive cohort has shown a decrease in HD mortality rates. None of the various hypotheses put forward to explain the recent decline in HD mortality provides a cogent explanation for the differential effects in men and women. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART diseases
KW - DEATH
KW - MORTALITY
KW - WOMEN -- Health
KW - DEMOGRAPHY
KW - SOCIAL indicators
KW - GENDER
KW - HYPOTHESIS
KW - MEN -- United States
N1 - Accession Number: 4950997; Patrick, Clifford H. 1 Palesch, Yuko Y. 2 Feinleib, Manning 3 Brody, Jacob A. 4; Affiliation: 1: Office of Research and Statistics, SSA, National Institute of Health 2: Epilepsy Branch, Neurological Disorders Program, NHLBI, National Institute of Health 3: Epidemiology and Biometry Program, Division of Heart and Vascular Diseases, NHLBI, National Institute of Health 4: Epidemiology, Demography, and Biometry Program, National institute on Aging, Federal Building, Room 612, Bethesda, MD 20205; Source Info: Feb1982, Vol. 72 Issue 2, p161; Subject Term: HEART diseases; Subject Term: DEATH; Subject Term: MORTALITY; Subject Term: WOMEN -- Health; Subject Term: DEMOGRAPHY; Subject Term: SOCIAL indicators; Subject Term: GENDER; Subject Term: HYPOTHESIS; Subject Term: MEN -- United States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yanagihara, R.H.
AU - Adler, W.H.
T1 - Inhibition of mouse natural killer activity by cyclosporin A.
JO - Immunology
JF - Immunology
Y1 - 1982/02//
VL - 45
IS - 2
M3 - Article
SP - 325
EP - 332
PB - Wiley-Blackwell
SN - 00192805
AB - Cyclosporin A (CSA), administered in vivo or in vitro, inhibited the spontaneous cytotoxicity of C57BL/6 and NZB/WF1 mouse spleen cells against YAC and K562 target cells in a 4 hr 51Crk release assay. Inhibition of natural killing (NK) by CSA occurred rapidly, was dose-dependent, and did not require the presence of T cells, B cells or macrophages. CSA depressed NK activity by direct interaction with NK cells. There was no evidence that inhibition of NK by CSA was mediated through suppressor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - CYCLOSPORINE
KW - T cells
KW - B cells
KW - CELL interaction (Biology)
KW - SUPPRESSOR cells
N1 - Accession Number: 13950244; Yanagihara, R.H. 1 Adler, W.H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, U.S.A.; Source Info: Feb82, Vol. 45 Issue 2, p325; Subject Term: KILLER cells; Subject Term: CYCLOSPORINE; Subject Term: T cells; Subject Term: B cells; Subject Term: CELL interaction (Biology); Subject Term: SUPPRESSOR cells; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06541-002
AN - 2006-06541-002
AU - Shah, Saleem A.
T1 - Ethical Issues for Psychologists in the Criminal Justice System.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/02//
VL - 27
IS - 2
SP - 87
EP - 88
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06541-002. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; Center for Studies of Crime and Delinquency, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Criminal Behavior; Criminal Justice; Ethics; Forensic Psychology. Classification: Criminal Law & Adjudication (4230). Population: Human (10). Reviewed Item: Monahan, John (Ed). Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System=Washington, D.C.: American Psychological Association, 1980. 174 pp. $7.50 paper; 1980. Page Count: 2. Issue Publication Date: Feb, 1982.
AB - Reviews the book, Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System by John Monahan (Ed.) (see record [rid]1982-06341-000[/rid]). This book is the complete report of the APA Task Force on the Role of Psychology in the Criminal Justice System. The purpose of the Task Force, chaired by Monahan, was 'to investigate comprehensively the complex ways in which psychologists are involved in the criminal justice system and the ethical issues raised by this involvement'. The report attempts to isolate the key ethical issues for psychologists in criminal justice work and provides recommendations on the ethical course that psychology, as a profession, should set in this area. As in most compilations the contributions vary somewhat in their quality, but all are informative, thoughtfully done, and useful. In conclusion, the book is an informative and important report and one that should be used widely. It would be an excellent item for the long-needed graduate courses in applied ethics and related concerns in psychological practice and research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - criminal justice system
KW - ethical issues
KW - psychologists
KW - clients
KW - 1982
KW - Criminal Behavior
KW - Criminal Justice
KW - Ethics
KW - Forensic Psychology
KW - 1982
U2 - Monahan, John (Ed). (1980); Who is the Client? The Ethics of Psychological Intervention in the Criminal Justice System; Washington, D.C.: American Psychological Association, 1980. 174 pp. $7.50 paper
DO - 10.1037/020987
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06541-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06541-043
AN - 2006-06541-043
AU - Susman, Elizabeth J.
T1 - Surviving Childhood Cancer: Social and Psychological Stresses for Children and Families.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/02//
VL - 27
IS - 2
SP - 133
EP - 134
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06541-043. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Susman, Elizabeth J.; National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061120. Correction Date: 20151207. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Emotional Adjustment; Neoplasms; Survivors. Minor Descriptor: Psychosocial Factors; Consequence. Classification: Cancer (3293). Reviewed Item: Koocher, Gerald P.; O'Malley, John E. The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer=New York: McGraw-Hill, 1981. 239 pp. $17.95; 1981. Page Count: 2. Issue Publication Date: Feb, 1982.
AB - Reviews the book, The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer by Gerald P. Koocher and John E. O'Malley (1981). The Damocles Syndrome is a historical precedent from two perspectives. First, only now in the history of treatment of childhood cancer could the authors have amassed a significantly large group of survivors to be the focus of scientific inquiry. Second, the book presents findings from one of the largest studies of psychosocial aspects of childhood cancer yet to be undertaken. As the title implies, it is the potential for long-term survival that is at the heart of the survivor's dilemma. The purpose of the book is to present the findings of an empirical study of the psychological vulnerabilities and invulnerabilities of having survived cancer in both the victims and their families. Ultimately, the book will prove to be of great benefit to both researchers and clinicians. In summary, the book is a needed and valuable resource for understanding this highly stressful and emotionally charged aspect of human experience. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - surviving childhood cancer
KW - Damocles Syndrome
KW - psychosocial consequences
KW - history
KW - treatment
KW - 1982
KW - Childhood Development
KW - Emotional Adjustment
KW - Neoplasms
KW - Survivors
KW - Psychosocial Factors
KW - Consequence
KW - 1982
U2 - Koocher, Gerald P.; O'Malley, John E. (1981); The Damocles Syndrome: Psychosocial Consequences of Surviving Childhood Cancer; New York: McGraw-Hill, 1981. 239 pp. $17.95
DO - 10.1037/020947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06541-043&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06541-053
AN - 2006-06541-053
AU - Zahn, Theodore P.
T1 - A Perspective on Schizophrenia.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/02//
VL - 27
IS - 2
SP - 146
EP - 147
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06541-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Biopsychosocial Approach; Schizophrenia. Minor Descriptor: Phenomenology. Classification: Schizophrenia & Psychotic States (3213). Reviewed Item: Crider, Andrew. Schizophrenia: A Biopsychological Perspective=Hillsdale, N.J.: Erlbaum, 1979. 214 pp. $16.50; 1979. Page Count: 2. Issue Publication Date: Feb, 1982.
AB - Reviews the book, Schizophrenia: A Biopsychological Perspective by Andrew Crider (1979). The purpose of this book is 'to organize and to evaluate current concepts and findings...with a view toward the integrative possibilities they suggest'. The book presents views of various aspects of schizophrenia that most likely represented the consensus of students of this disorder about 1978. The volume's general flavor is captured by its goal to try 'to tell one story rather than many'. The book focuses on a few of the seminal research reports, reviews, or books as source material. The results of this paring is a clear, readable presentation of the most influential ideas and research findings. As far as the basic nature of schizophrenia is concerned, Crider relies almost exclusively on phenomenology as a data base. In conclusion, this book presents a better-than-adequate introduction to current concepts of schizophrenia for those in patient-care roles. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - biopsychological perspective
KW - patient-care roles
KW - phenomenology
KW - 1982
KW - Biopsychosocial Approach
KW - Schizophrenia
KW - Phenomenology
KW - 1982
U2 - Crider, Andrew. (1979); Schizophrenia: A Biopsychological Perspective; Hillsdale, N.J.: Erlbaum, 1979. 214 pp. $16.50
DO - 10.1037/020957
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06541-053&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06541-056
AN - 2006-06541-056
AU - Levitsky, David A.
AU - Strupp, Barbara J.
T1 - Reinforcing Health Care.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/02//
VL - 27
IS - 2
SP - 149
EP - 150
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06541-056. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levitsky, David A.; Division of Nutritional Sciences, Department of Psychology, Cornell University, Ithaca, NY, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Media. Language: English. Major Descriptor: Diets; Health Care Services; Nutrition; Nutritional Deficiencies. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Reviewed Item: Guthrie, George M.; Guthrie, Helen A. Preventing Malnutrition by Reinforcing Improved Diets=(Distributor Audio Visual Services, Pennsylvania State University, University Park, Pa, 16802) Sound and color, 28 minutes. $385.00 (16 mm.), $250.00 (video), $18.50 (16 mm rental); No Year Specified. Page Count: 2. Issue Publication Date: Feb, 1982.
AB - Reviews the film, Preventing Malnutrition by Reinforcing Improved Diets by George M. Guthrie and Helen A. Guthrie. The intention of this film produced by George and Helen Guthrie is to describe a field experiment in a rural community in the Philippines. The hypothesis is not only interesting, but also extremely important to millions of poor people living in poverty, disease, and malnutrition. The Guthries well understand the complexity involved in solving the problem of malnutrition. At first glance, the conclusion appears almost inhumane and conflicts with our idealistic concept of 'motherly love,' but on closer scrutiny it seems consistent with much of what we know about health care. However, the greatest flaw in the film as a medium for stimulating college audiences is its apparent superficiality. The apparent lack of depth in the film, which concerns a subject matter and an idea as profound as the use of reinforcement to eliminate malnutrition, makes this film best suited as a stimulus for discussion at an advanced level in psychology, anthropology, sociology, or nutrition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care
KW - preventing malnutrition
KW - improved diets
KW - 1982
KW - Diets
KW - Health Care Services
KW - Nutrition
KW - Nutritional Deficiencies
KW - 1982
U2 - Guthrie, George M.; Guthrie, Helen A. (No Year Specified); Preventing Malnutrition by Reinforcing Improved Diets; (Distributor Audio Visual Services, Pennsylvania State University, University Park, Pa, 16802) Sound and color, 28 minutes. $385.00 (16 mm.), $250.00 (video), $18.50 (16 mm rental)
DO - 10.1037/020960
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06541-056&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - MARTIN, SAMUEL P.
AU - SINGER, MAXINE
T1 - Confronting Creationism.
JO - Science
JF - Science
Y1 - 1982/02/05/
VL - 215
IS - 4533
M3 - Article
SP - 612
EP - 612
SN - 00368075
N1 - Accession Number: 84704952; MARTIN, SAMUEL P. 1; SINGER, MAXINE 2; Affiliations: 1: Department of Anthropology, University of Illinois, Chicago Circle Campus, Chicago 60680; 2: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p612; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stetten Jr., DeWitt
T1 - Philip Handler: An Appreciation (13 August 1917-29 December 1981).
JO - Science
JF - Science
Y1 - 1982/02/05/
VL - 215
IS - 4533
M3 - Article
SP - 633
EP - 634
SN - 00368075
N1 - Accession Number: 84704959; Stetten Jr., DeWitt 1; Affiliations: 1: Senior Scientific Advisor, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p633; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ALKON, DANIEL L.
AU - LEDERHENDLER, IZJA
AU - SHOUKIMAS, JONATHAN J.
T1 - Primary Changes of Membrane Currents During Retention of Associative Learning.
JO - Science
JF - Science
Y1 - 1982/02/05/
VL - 215
IS - 4533
M3 - Article
SP - 693
EP - 695
SN - 00368075
AB - A single identified neuron was repeatedly isolated by axotomy from the central nervous system of the nudibranch mollusk Hermissenda crassicornis. An early voltage-dependent outward K+ current of this neuron was reduced and more rapidly inactivated for animals previously trained with paired but not randomized light and rotation. Since this current change can affect interneuron and motorneuron output via known synaptic pathways, it helps explain a long-lasting behavioral change that shows the defining features of vertebrate associative learning. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705005; ALKON, DANIEL L. 1; LEDERHENDLER, IZJA 1; SHOUKIMAS, JONATHAN J. 1; Affiliations: 1: Section on Neural Systems, Laboratory of Biophysics, National Institutes of Health, Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 2/ 5/1982, Vol. 215 Issue 4533, p693; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yuan-Tsong Chen
AU - Lang, Matti A.
AU - Jensen, Nancy M.
AU - Negishi, Masahiko
AU - Tukey, Robert H.
AU - Sidransky, Ellen
AU - Guenther, Thomas M.
AU - Nebert, Daniel W.
T1 - Similarities between Mouse and Rat-Liver Microsomal Cytochromes P-450 Induced by 3-Methylanthrene.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1982/02/15/
VL - 122
IS - 2
M3 - Article
SP - 361
EP - 368
PB - Wiley-Blackwell
SN - 00142956
AB - Anti-(P1-450) and anti-(P-448) are two antibodies developed against distinctly different Forms of 3-methyl- cholanthrene-induced cytochrome P-450 in C57BL/6N mouse liver microsomes [Negishi and Nebert, J. Blot C/win. 254, 11015-11023 (1979)]. The effects of these antibodies on long-Evans and Sprague-Dawley rat liver microsomes and rat `minimal deviation' hepatoma 7777 microsomes were studied. Rat microsomal aryl hydrocarbon hydroxylase activity, induced by polycyclic aromatic compounds, is preferentially inhibited by anti-(Pi-450) more so than anti-(P-448). Polycyclic-aromatic-induced rat liver microsomal acetanilide 4-hydroxylase activity is preferentially inhibited by anti-(P-448) more so than anti-(P,-450). Anti (P1 -450) precipitates a 56-kDa moiety in polycyclic aromatic-induced rat liver microsomes. Anti-(P-448) precipitates a 55-kDa moiety in control, phenobarbital-treated, or polycyclic-aromatic-induced rat liver microsomes. A heterogeneity was found amongst individual Morris `minimal deviation' hepatomas 7777. indicating the 3-metliylcholanthrene-induced aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase activities must represent different forms of rat P1-450. Clone 46 DNA, a portion of the mouse cloned P1-450 structural gene. hybridizes to one gene (or a small number of genes) in rat liver and to 3-niethylcholanthrene-induced rat 23-S P1-450 mRNA. As has already been shown in the mouse [Tukey, Nebert and Negishi, J. Biol. Chem. 256, 6969-6974 (1981)], rat liver P1-450 induction is under transcriptional control, and there is no evidence for gene amplification or some gross form of DNA rearrangement. These data demonstrate striking similarities between rat and mouse for the P1-450 structural gene, the P1-450 mRNA, the P1-450 protein and the P-448 protein. Polycyclic-aronlatic-induced P1-450, and its association with polycyclic-aromatic-induced aryl hydrocarbon hydroxylase activity, therefore does not appear to be closely correlated with polycyclic-aromatic-induced P-448 in either rat or mouse. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER cells
KW - MICROSOMES
KW - CYTOCHROME P-450
KW - PROTOPLASM
KW - BILIARY tract
KW - ORGANIC compounds
KW - IMMUNOGLOBULINS
N1 - Accession Number: 13827854; Yuan-Tsong Chen 1,2,3 Lang, Matti A. 1,2,3 Jensen, Nancy M. 1,2,3 Negishi, Masahiko 1,2,3 Tukey, Robert H. 1,2,3 Sidransky, Ellen 1,2,3 Guenther, Thomas M. 1,2,3 Nebert, Daniel W. 1,2,3; Affiliation: 1: Developmental Pharmacology Branch. 2: National Institute of Child Health and Human Development. 3: National Institutes of Health, Bethesda, Maryland; Source Info: 2/15/82, Vol. 122 Issue 2, p361; Subject Term: LIVER cells; Subject Term: MICROSOMES; Subject Term: CYTOCHROME P-450; Subject Term: PROTOPLASM; Subject Term: BILIARY tract; Subject Term: ORGANIC compounds; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MELNICK, VIJAYA L.
AU - DEAN, DONALD S.
T1 - Alzheimer's Disease: Research Guidelines.
JO - Science
JF - Science
Y1 - 1982/02/19/
VL - 215
IS - 4535
M3 - Article
SP - 913
EP - 914
SN - 00368075
N1 - Accession Number: 88003610; MELNICK, VIJAYA L. 1; DEAN, DONALD S. 2; Affiliations: 1: National Institute on Aging, Bethesda, Maryland 20205; 2: Biology Department, Baldwin-Wallace College, Berea, Ohio 44017; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p913; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROBERT-GUROFF, MARJORIE
AU - NAKAO, YOSHINOBU
AU - NOTAKE, KUNIHIRO
AU - ITO, YOHEI
AU - SLISKI, ANN
AU - GALLO, ROBERT C.
T1 - Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell Leukemia.
JO - Science
JF - Science
Y1 - 1982/02/19/
VL - 215
IS - 4535
M3 - Article
SP - 975
EP - 978
SN - 00368075
AB - Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from afew patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy including Japanese adult T cell leukemia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003649; ROBERT-GUROFF, MARJORIE 1; NAKAO, YOSHINOBU 2; NOTAKE, KUNIHIRO 3; ITO, YOHEI 4; SLISKI, ANN 1; GALLO, ROBERT C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Kobe University School of Medicine, Department of Medicine, Kobe, Japan; 3: Aichi Medical University, Department of Microbiology, Nagoya, Japan; 4: Kyoto University Faculty of Medicine, Department of Microbiology, Kyoto, Japan; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p975; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LOUMAYE, ERNEST
AU - CATT, KEVIN J.
T1 - Homologous Regulation of Gonadotropin-Releasing Hormone Receptors in Cultured Pituitary Cells.
JO - Science
JF - Science
Y1 - 1982/02/19/
VL - 215
IS - 4535
M3 - Article
SP - 983
EP - 985
SN - 00368075
AB - Specific receptors for gonadotropin-releasing hormone (GnRH) in cultured rat pituitary cells were increased by subnanomolar concentrations of GnRH agonists and decreased by high concentrations of these peptides. The antagonist [DPhe², Pro³,D-Phe6]GnRH did not alter GnRH binding capacity and blocked the increase in sites induced by GnRH. These findings provide direct evidence for the homologous regulation of GnRH receptors by physiological concentrations of the hypothalamic peptide, an action that could mediate the cyclical and postcastration increases in GnRH receptors and responsiveness of the pituitary gonadotrophs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003652; LOUMAYE, ERNEST 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p983; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KING, CHARLES R.
AU - SHINOHARA, TOSHIMICHI
AU - PIATIGORSKY, JORAM
T1 - αA-Crystallin Messenger RNA of the Mouse Lens: More Noncoding Than Coding Sequences.
JO - Science
JF - Science
Y1 - 1982/02/19/
VL - 215
IS - 4535
M3 - Article
SP - 985
EP - 987
SN - 00368075
AB - The 14S messenger RNA (1300 to 1500 nucleotides) for the αA chain of a-crystallin of the mammalian lens is nearly three times larger than required to code for the polypeptide that contains 173 amino acids. As a means of accounting for this anomaly, a complementary DNA clone for the mouse oA-crystallin messenger RNA was constructed in pBR322 and sequenced. Derivation of the protein sequence from the nucleic acid sequence showed that mouse αA-crystallin is similar to that of other organisms. The messenger RNA contains 536 nucleotides located on the 3' side of the coding region, excluding the polyadenylate stretch. This 3' sequence does not encode any other crystallin and has multiple termination codons in the three possible reading frames. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003653; KING, CHARLES R. 1; SHINOHARA, TOSHIMICHI 1; PIATIGORSKY, JORAM 1; Affiliations: 1: Laboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 2/19/1982, Vol. 215 Issue 4535, p985; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BRUNELLO, N.
AU - CHUANG, D. M.
AU - COSTA, E.
T1 - Different Synaptic Location of Mianserin and Imipramine Binding Sites.
JO - Science
JF - Science
Y1 - 1982/02/26/
VL - 215
IS - 4536
M3 - Article
SP - 1112
EP - 1115
SN - 00368075
AB - The high-affinity binding sites for mianserin and imipramine appear to be located in different neurons of rat brain. Studies in which lesions were produced with 5,7-dihydroxytryptamine and other studies in which the 5-hydroxytryptamine content was decreased with p-chlorophenylalanine indicate that some of the imipramine binding sites are on serotonin axon terminals and others are on nonserotonergic synapses. The sites that bind mianserin are on postsynaptic serotonin sites as well as on synapses of other neuronal systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003697; BRUNELLO, N. 1; CHUANG, D. M. 1; COSTA, E. 1; Affiliations: 1: Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 2/26/1982, Vol. 215 Issue 4536, p1112; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - O'DONOHUE, THOMAS L.
AU - HANDELMANN, GAIL E.
AU - MILLER, RUSSELL L.
AU - JACOBOWITZ, DAVID M.
T1 - N-Acetylation Regulates the Behavioral Activity of α-Melanotropin in a Multineurotransmitter Neuron.
JO - Science
JF - Science
Y1 - 1982/02/26/
VL - 215
IS - 4536
M3 - Article
SP - 1125
EP - 1127
SN - 00368075
AB - A multineurotransmitter neuronal system that synthesizes and secretes both acetylated and deacetylatedforms of a-melantropin and f-endorphin is present in rat and human brain. The N-acetylatedform of a-melanotropin had more potent behavioral effects than the deacetylated α-melanotropin. In the case of β-endorphin, however, the deacetylated form has been-shown to be more potent than the acetylated form. Enzymatic N-acetylation appears to be an important regulatory process for modulating the behavioral activity of peptides secreted from the opiomelanotropinergic multineurotransmitter neuron. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003703; O'DONOHUE, THOMAS L. 1; HANDELMANN, GAIL E. 2; MILLER, RUSSELL L. 3; JACOBOWITZ, DAVID M. 4; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health and National Institute of General Medical Sciences, Bethesda, Maryland 20205; 2: Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21205; 3: Department of Pharmacology and Medicine, Howard University, Washington, D.C. 20019; 4: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 2/26/1982, Vol. 215 Issue 4536, p1125; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moment, Gairdner
T1 - AGING IN MAMMALS.
JO - BioScience
JF - BioScience
Y1 - 1982/03//
VL - 32
IS - 3
M3 - Book Review
SP - 209
EP - 209
SN - 00063568
AB - The article reviews the book "Mammalian Models for Research on Aging."
KW - Laboratory animals
KW - Developmental biology
KW - Nonfiction
KW - Mammalian Models for Research on Aging (Book)
N1 - Accession Number: 28051432; Moment, Gairdner 1; Affiliations: 1 : Guest Scientist National Institute on Aging Professor of Biology Emeritus Goucher College Baltimore, MD; Source Info: Mar1982, Vol. 32 Issue 3, p209; Subject Term: Laboratory animals; Subject Term: Developmental biology; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 691
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Lemanske, Jr., R. F.
AU - Kaliner, M. A.
T1 - The experimental production of increased eosinophils in rat late-phase reactions.
JO - Immunology
JF - Immunology
Y1 - 1982/03//
VL - 45
IS - 3
M3 - Article
SP - 561
EP - 568
PB - Wiley-Blackwell
SN - 00192805
AB - The effects of peripheral eosinophilia on the intensity, kinetics and cellular characteristics of rat cutaneous late-phase reactions (LPR) have been investigated. Two distinct methods of inducing peripheral eosinophilia did not alter either the intensity or the kinetics of LPR produced by the intradermal injection of anti-IgE, Compound 48/80, or isolated mast cell granules. Hypereosinophilic animals exhibited increased numbers of tissue eosinophils in LPR tissue sites which correlated with the elevations in their respective peripheral eosinophil counts: however, the absolute number of eosinophils present, although significant, was not impressive («10% of total). Our data suggest that, although rat LPR can be modulated to involve increased tissue eosinophils by increasing the numbers of peripheral blood eosinophils, no effects of these procedures on altering either the intensity or the kinetics of these reactions can be appreciated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EOSINOPHILIA
KW - EOSINOPHILS
KW - GRANULOCYTES
KW - RATS as laboratory animals
KW - EOSINOPHIL disorders
KW - LABORATORY animals
N1 - Accession Number: 14004146; Lemanske, Jr., R. F. 1 Kaliner, M. A. 1; Affiliation: 1: National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar82, Vol. 45 Issue 3, p561; Subject Term: EOSINOPHILIA; Subject Term: EOSINOPHILS; Subject Term: GRANULOCYTES; Subject Term: RATS as laboratory animals; Subject Term: EOSINOPHIL disorders; Subject Term: LABORATORY animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Small, Arnold
AU - Teagno, Lorie
AU - Madero, James
AU - Gross, Howard
AU - Eberts, Michael
T1 - A Comparison of Anorexics and Schizophrenics on Psychodiagnostic Measures.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 1982///Spring1982
VL - 1
IS - 3
M3 - Article
SP - 49
EP - 56
PB - John Wiley & Sons, Inc.
SN - 02763478
N1 - Accession Number: 11975641; Small, Arnold 1 Teagno, Lorie 2 Madero, James 3 Gross, Howard 3 Eberts, Michael 3; Affiliation: 1: George Mason University & Family and Child Development Services of Va. 2: University of Maryland. 3: National Institute of Mental Health.; Source Info: Spring1982, Vol. 1 Issue 3, p49; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scudiero, Dominic A.
AU - Moshell, Alan N.
AU - Scarpinato, Ronald G.
AU - Meyer, Sharon A.
AU - Clatterbuck, Brian E.
AU - Tarone, Robert E.
AU - Robbins, Jay H.
T1 - Lymphoblastoid Lines and Skin Fibroblasts from Patients with Tuberous Sclerosis Are Abnormally Sensitive to Ionizing Radiation and to a Radiomemetic Chemical.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/03//
VL - 78
IS - 3
M3 - Article
SP - 234
EP - 238
SN - 0022202X
AB - Lymphoblastoid lines, derived by transforming peripheral blood lymphocytes with Epstein-Barr virus, and skin fibroblast lines were established from two patients with tuberous sclerosis. The number of viable lymphoblastoid cells was determined by their ability to exclude the vital dye trypan blue after their irradiation with x-rays or 254 nm ultraviolet light. The growth of fibroblasts was determined by their ability to form colonies after treatment with the radiomimetic, DNA-damaging chemical N-methyl-N'-nitro-N-nitrosoguanidine. The tuberous sclerosis lymphoblastoid lines were hypersensitive to x-rays but had normal sensitivity to the ultraviolet radiation. The tuberous sclerosis fibroblast lines were hypersensitive to the N-methyl-N'-nitro-N-nitrosoguanidine. The hypersensitivity of tuberous sclerosis cells to x-rays and to N-methyl-N'-nitro-N-nitrosoguanidine is believed to reflect defective repair of DNA damaged by these agents and may provide the basis for in vitro, including prenatal, diagnostic tests for tuberous sclerosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBEROUS sclerosis
KW - MENTAL disabilities
KW - ULTRAVIOLET radiation
KW - LEUCOCYTES
KW - EPSTEIN-Barr virus
KW - X-rays
N1 - Accession Number: 12506550; Scudiero, Dominic A. 1,2 Moshell, Alan N. 1,2 Scarpinato, Ronald G. 1,2 Meyer, Sharon A. 1,2 Clatterbuck, Brian E. 1,2 Tarone, Robert E. 1,2 Robbins, Jay H. 1,2; Affiliation: 1: Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick, Maryland. 2: Dermatology and Biometry Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1982, Vol. 78 Issue 3, p234; Subject Term: TUBEROUS sclerosis; Subject Term: MENTAL disabilities; Subject Term: ULTRAVIOLET radiation; Subject Term: LEUCOCYTES; Subject Term: EPSTEIN-Barr virus; Subject Term: X-rays; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12506550
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malley, James D.
T1 - Simultaneous Confidence Intervals for Ratios of Normal Means.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1982/03//
VL - 77
IS - 377
M3 - Article
SP - 170
SN - 01621459
AB - Given one or more groups of multivariate normal samples, methods are presented for forming, simultaneous confidence intervals of all ratios of linear forms of the mean vectors. The methods cover the cases of equal or unequal covariances. In a simultaneous inference context, they are multivariate extensions of a method due to Fieller (1954) for estimation of the ratio of two normal means. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIVARIATE analysis
KW - ANALYSIS of covariance
KW - ANALYSIS of variance
KW - ESTIMATION theory
KW - MATHEMATICAL statistics
KW - LINEAR models (Statistics)
KW - MATHEMATICAL models
KW - SIMULTANEOUS equations
KW - CONFIDENCE intervals
KW - Constrained estimation.
KW - Multivariate normal
KW - Ratio estimation
KW - Simultaneous inference
N1 - Accession Number: 4603811; Malley, James D. 1; Affiliations: 1: Research and consulting statistician, Laboratory of Statistical and Mathematical Methodology, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20205.; Issue Info: Mar1982, Vol. 77 Issue 377, p170; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: MATHEMATICAL models; Subject Term: SIMULTANEOUS equations; Subject Term: CONFIDENCE intervals; Author-Supplied Keyword: Constrained estimation.; Author-Supplied Keyword: Multivariate normal; Author-Supplied Keyword: Ratio estimation; Author-Supplied Keyword: Simultaneous inference; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2006-06540-037
AN - 2006-06540-037
AU - Newman, Sidney H.
T1 - A Multidisciplinary Approach to Fertility and Family Planning.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/03//
VL - 27
IS - 3
SP - 224
EP - 225
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06540-037. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Newman, Sidney H.; Center for Population Research, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Birth Control; Fertility. Minor Descriptor: Social Sciences. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Shain, Rochelle N. (Ed); Pauerstein, Carl J. (Ed). Fertility Control: Biologic and Behavioral Aspects=Hagerstown, Md.: Harper & Row, 1980 459 pp. $35 00 cloth; 1980. Page Count: 2. Issue Publication Date: Mar, 1982.
AB - Reviews the book, Fertility Control: Biologic and Behavioral Aspects edited by Rochelle N. Shain and Carl J. Pauerstein (1980). This is the first book in which there has been a significant amalgamation of behavioral-social, biological, and clinical sciences involved in research and training in the areas of fertility and fertility regulation, as well as in family planning activities. The value of the book is enhanced by the clarity of writing; specific efforts were made to diminish the language barrier that usually exists between behavioral-social and biomedical scientists. This reviewer suggests that if this book is revised, consideration be given to increasing the kinds of behavioral-social science specialists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fertility
KW - family planning
KW - fertility regulation
KW - 1982
KW - Birth Control
KW - Fertility
KW - Social Sciences
KW - 1982
U2 - Shain, Rochelle N. (Ed); Pauerstein, Carl J. (Ed). (1980); Fertility Control: Biologic and Behavioral Aspects; Hagerstown, Md.: Harper & Row, 1980 459 pp. $35 00 cloth
DO - 10.1037/021032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06540-037&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - BUSTIN, MICHAEL
AU - REISCH, JOANNE
AU - EINCK, LEO
AU - KLIPPEL, JOHN H.
T1 - Autoantibodies to Nucleosomal Proteins: Antibodies to HMG-17 in Autoimmune Diseases.
JO - Science
JF - Science
Y1 - 1982/03/05/
VL - 215
IS - 4537
M3 - Article
SP - 1245
EP - 1247
SN - 00368075
AB - The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88017655; BUSTIN, MICHAEL 1; REISCH, JOANNE 1; EINCK, LEO 1; KLIPPEL, JOHN H. 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: Arthritis and Rheumatism Branch, National Institute of Arthritis, Bethesda, Maryland 20205; Issue Info: 3/ 5/1982, Vol. 215 Issue 4537, p1245; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RUDA, M. A.
T1 - Opiates and Pain Pathways: Demonstration of Enkephalin Synapses on Dorsal Horn Projection Neurons.
JO - Science
JF - Science
Y1 - 1982/03/19/
VL - 215
IS - 4539
M3 - Article
SP - 1523
EP - 1525
SN - 00368075
AB - The participation of the opiate peptide enkephalin in the neural circuitry of the dorsal horn was examined at the light and ultrastructural level through the use of the combined techniques of immunocytochemistry and retrograde transport of horseradish peroxidase. Enkephalin immunoreactive axonal endings made direct synaptic contact with the soma and proximal dendrites of dorsal horn thalamic projection neurons. This observation demonstrates that one major synaptic site of enkephalin modulation of the transfer of nociceptive information in the dorsal horn is on the projection neurons themselves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705088; RUDA, M. A. 1; Affiliations: 1: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 3/19/1982, Vol. 215 Issue 4539, p1523; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoover, Robert
AU - Hartge, Patricta
T1 - Non-Nutritive Sweeteners and Bladder Cancer.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/04//
VL - 72
IS - 4
M3 - Article
SP - 382
EP - 383
PB - American Public Health Association
SN - 00900036
AB - The article comments on an analysis conducted by Alexander M. Walker et al., regarding the U.S. National Cancer Institute's study on non-nutritive sweeteners and bladder cancer. The authors state that the reanalysis of Walker et al., has yielded the same findings that they reported, that there is no evidence of any association between bladder cancer risk and past consumption of artificial sweeteners. Walker et al., claim that control for a variety of factors through multivariate techniques diminished the plausibility of earlier interpretations of the subgroup findings.
KW - CANCER research
KW - NONNUTRITIVE sweeteners
KW - SWEETENERS
KW - BLADDER
KW - URINARY organs
KW - NATIONAL Cancer Institute (U.S.)
KW - WALKER, Alexander M.
N1 - Accession Number: 4949144; Hoover, Robert 1 Hartge, Patricta 1; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute; Source Info: Apr1982, Vol. 72 Issue 4, p382; Subject Term: CANCER research; Subject Term: NONNUTRITIVE sweeteners; Subject Term: SWEETENERS; Subject Term: BLADDER; Subject Term: URINARY organs; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: WALKER, Alexander M.; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, W. R.
AU - Smith, P. D.
AU - Lee, Evelyn
AU - McCalmon, R. T.
AU - Nagura, H.
T1 - A search for an enriched source of polymeric IgA in human thoracic duct lymph, portal vein blood and aortic blood.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/04//
VL - 48
IS - 1
M3 - Article
SP - 85
EP - 90
PB - Wiley-Blackwell
SN - 00099104
AB - Because human bile contains a lot of secretory IgA, it has been suspected that the human liver, like rat liver, transfers polymeric IgA from plasma to bile. Hence, a rich source of polymeric IgA might enter the general circulation of man. We examined human thoracic duct lymph, portal vein blood and aortic blood for content and molecular size of IgA. None of the fluids was found to have either a higher total concentration of IgA or a higher proportion of polymeric IgA than that found in peripheral venous blood. It is possible that hepatic clearance of plasma IgA does not occur in man to the extent that it does in the rat, and a relatively larger proportion of human biliary IgA might originate from synthesis in hepatobiliary tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - AORTIC paraganglia
KW - BILIARY tract
KW - BLOOD-vessels
KW - PRESERVATION of organs, tissues, etc.
KW - LIVER
N1 - Accession Number: 16334613; Brown, W. R. 1 Smith, P. D. 2 Lee, Evelyn 1 McCalmon, R. T. 3 Nagura, H. 4; Affiliation: 1: The Departments of Medicine (Gastroenterology) and Surgery, The Veterans Administration Medical Center, The University of Colorado School of Medicine, Denver, Colorado, USA 2: Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. 3: Immunological Associates of Denver, Denver, Colorado, USA. 4: The School of Medicine, Tokai University, Japan; Source Info: Apr1982, Vol. 48 Issue 1, p85; Subject Term: IMMUNOGLOBULINS; Subject Term: AORTIC paraganglia; Subject Term: BILIARY tract; Subject Term: BLOOD-vessels; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: LIVER; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42249-011
AN - 2013-42249-011
AU - Davenport, Yolande B.
AU - Adland, Marvin L.
T1 - Postpartum psychoses in female and male bipolar manic-depressive patients.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1982/04//
VL - 52
IS - 2
SP - 288
EP - 297
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Davenport, Yolande B., Chief Unit on Family Studies, Clinical Psychobiology Branch, Clinical Center, NIMH, Room 4S239, Bethesda, MD, US, 20205
N1 - Accession Number: 2013-42249-011. PMID: 7081399 Partial author list: First Author & Affiliation: Davenport, Yolande B.; Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Major Depression; Risk Factors. Minor Descriptor: Fathers; Human Females; Mania; Psychosis. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 1982.
AB - Bipolar manic-depressive women are considered a special risk for recurrence of a childbirth-related affective episode. In a chart study of 40 fathers who are former bipolar patients, 21 had histories of an affective episode in proximity to a wife's pregnancy. When these bipolar fathers were compared with the 19 for whom no such episodes were recorded, differences were found on several parameters. Therapeutic implications of the findings are considered, und recommendations for further study are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - postpartum psychoses
KW - bipolar disorders
KW - manic depressive patients
KW - special risk
KW - 1982
KW - Bipolar Disorder
KW - Major Depression
KW - Risk Factors
KW - Fathers
KW - Human Females
KW - Mania
KW - Psychosis
KW - 1982
DO - 10.1111/j.1939-0025.1982.tb02689.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - O'Brien, Stephen J.
AU - Nash, William G.
T1 - Genetic Mapping in Mammals: Chromosome Map of Domestic Cat.
JO - Science
JF - Science
Y1 - 1982/04/16/
VL - 216
IS - 4543
M3 - Article
SP - 257
EP - 265
SN - 00368075
N1 - Accession Number: 84705236; O'Brien, Stephen J. 1; Nash, William G. 2; Affiliations: 1: Chief, Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Senior staff scientist, Carcinogenesis Intramural Research Program, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p257; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KIRSCH, ILAN R.
AU - MORTON, CYNTHIA C.
AU - NAKAHARA, KENNETH
AU - LEDER, PHILIP
T1 - Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes.
JO - Science
JF - Science
Y1 - 1982/04/16/
VL - 216
IS - 4543
M3 - Article
SP - 301
EP - 303
SN - 00368075
AB - A human immunoglobulin heavy chain (y4) gene is mapped by chromosome hybridization in situ. This gene is located at band J4q32, a site commonly involved in a chromosomal translocation characteristic of malignant B cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705264; KIRSCH, ILAN R. 1; MORTON, CYNTHIA C. 2; NAKAHARA, KENNETH 3; LEDER, PHILIP 4,5; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298; 3: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20205; 4: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda; 5: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p301; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hu, P. C.
AU - COLE, R. M.
AU - HUANG, Y. S.
AU - GRAHAM, J. A.
AU - GARDNER, D. E.
AU - COLLIER, A. M.
AU - CLYDE JR., W. A.
T1 - Mycoplasma pneumoniae Infection: Role of a Surface Protein in the Attachment Organelle.
JO - Science
JF - Science
Y1 - 1982/04/16/
VL - 216
IS - 4543
M3 - Article
SP - 313
EP - 315
SN - 00368075
AB - Attachment of Mycoplasma pneumoniae to host cells by means of a specialized terminus initiates infection. Monoclonal antibodies to a surface protein (P1) inhibit this process, and react with a region of the tip covered with peplomer-like particles. Since antibodies against the P1 protein are generated by natural and experimental infection and by immunization, the substance may be an important determinant of protective immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705270; Hu, P. C. 1; COLE, R. M. 2; HUANG, Y. S. 3; GRAHAM, J. A. 3; GARDNER, D. E. 3; COLLIER, A. M. 4; CLYDE JR., W. A. 4; Affiliations: 1: Northrop Service Inc.- Environmental Science, Research Triangle Park, North Carolina 27709; 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Health Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711; 4: Department of Pediatrics, Frank Porter Graham Child Development Center, and Center for Environmental Health and Medical Sciences, University of North Carolina, Chapel Hill 27514; Issue Info: 4/16/1982, Vol. 216 Issue 4543, p313; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HIRAKAWA, TADASHI
AU - KAKUNAGA, TAKEO
AU - FUJIKI, HIROTA
AU - SUGIMURA, TAKASHI
T1 - A New Tumor-Promoting Agent, Dihydroteleocidin B, Markedly Enhances Chemically Induced Malignant Cell Transformation.
JO - Science
JF - Science
Y1 - 1982/04/30/
VL - 216
IS - 4545
M3 - Article
SP - 527
EP - 529
SN - 00368075
AB - Teleocidin, which was isolated from mycelia of Streptomyces, is a potent tumor promoter in mouse skin. The catalytically hydrogenated compound dihydroteleocidin B markedly enhanced malignant cell transformation induced by 3-methylcholanthrene or ultraviolet radiation. Dihydroteleocidin B was at least 100 times more effective in enhancing transformation than 12-O-tetradecanoyl phorbol-13- acetate, the strongest promoter known until now, whereas both promoters showed equal capacities to induce early membrane effects and DNA synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705358; HIRAKAWA, TADASHI 1; KAKUNAGA, TAKEO 1; FUJIKI, HIROTA 2; SUGIMURA, TAKASHI 2; Affiliations: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: National Cancer Center Research Institute, Tokyo 104, Japan; Issue Info: 4/30/1982, Vol. 216 Issue 4545, p527; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moment, Gairdner
T1 - VANISHED SPECIES.
JO - BioScience
JF - BioScience
Y1 - 1982/05//
VL - 32
IS - 5
M3 - Book Review
SP - 345
EP - 345
SN - 00063568
AB - The article reviews the book "The Doomsday Book of Animals: A Natural History of Vanished Species," by David Day.
KW - Animals & history
KW - Nonfiction
KW - Day, David
KW - Doomsday Book of Animals: A Natural History of Vanished Species, The (Book)
N1 - Accession Number: 28051504; Moment, Gairdner 1; Affiliations: 1 : Goucher College Guest Scientist National Institute on Aging Gerontology Research Center Baltimore, MD 21224; Source Info: May1982, Vol. 32 Issue 5, p345; Subject Term: Animals & history; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 656
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Balow, J. E.
AU - Huston, D. P.
AU - Wei, N.
AU - Decker, J. L.
T1 - Effect of plasmapheresis on T and B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/05//
VL - 48
IS - 2
M3 - Article
SP - 449
EP - 457
PB - Wiley-Blackwell
SN - 00099104
AB - Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmapheresis. In the present communication we report the effects of these procedures on T lymphocytes in peripheral mono nuclear cells, proliferative responses to mitogens, allogeneic mixed lymphocyte reaction and cell-mediated lympho lysis, as well as the effect of plasmapheresis on the spontaneous and pokeweed mitogen induced immunoglobulin secreting cells in peripheral blood. Several mono nuclear cell functions were abnormal at the beginning of the study but no significant changes related to plasmapheresis occurred in any of the parameters studied. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - AUTOIMMUNE diseases
KW - SYSTEMIC lupus erythematosus
KW - VASCULAR diseases
KW - B cells
KW - LEUCOCYTES
N1 - Accession Number: 16346375; Tsokos, G. C. 1 Balow, J. E. 2 Huston, D. P. 1 Wei, N. 1 Decker, J. L. 2; Affiliation: 1: The Arthritis and Rheumatism Branch. National Institute of Arthritis, Diabetes. Digestive and Kidney Diseases, 2: National Institutes of Health, Bethesda, Maryland. USA; Source Info: May1982, Vol. 48 Issue 2, p449; Subject Term: SKIN diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: VASCULAR diseases; Subject Term: B cells; Subject Term: LEUCOCYTES; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rollwagen, Florence M.
AU - Mathieson, Bonnie J.
AU - Asofsky, R.
T1 - Positive selection of T-cell subsets I. PROLIFERATIVE RESPONSES OF LYT 2 SEPARATED THYMOCYTES AND SPLENIC T CELLS.
JO - Immunology
JF - Immunology
Y1 - 1982/05//
VL - 46
IS - 1
M3 - Article
SP - 49
EP - 58
PB - Wiley-Blackwell
SN - 00192805
AB - Flow microfluorometry analysis of peanut lectin non-agglutinable (PNA-) thymocytes (ThC) reveals the existence of 30%-50% Lyt 1,2,3+ and 50%-70% Lyt 1+,2,3- subpopulations. Using positive selection on anti-immunoglobulin-coated (Mage) plates, we selected PNA- Lyt 2+ and PNA- Lyt 2- ThC as well as their peripheral counterparts in the spleen. These populations were tested in parallel for their ability to respond to concanavalin A (Con A) and phytohaemagglutinin (PHA), to respond to allogeneic stimulation in the mixed lymphocyte reaction (MLR); ThC subpopulations were also tested for their ability to provide synergy with lymph node cells (LNC) in the MLR. It was found that (a) Lyt 2- cells of both thymic and splenic origin responded to all doses of Con A or PHA; (b) PNA- Lyt 2+ ThC were unresponsive to Con A or PHA, whereas splenic Lyt 2+ T cells responded to low doses of mitogens; and (c) PNA- ThC of both Lyt phenotypes responded in a MLR and provided synergy with LNC in the MLR. These data support the notion that Lyt 2+ cells of either PNA- or PNA+ subpopulations must undergo post-thymic maturation before becoming responsive to low doses of T-cell mitogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - CELL proliferation
KW - FLUORIMETRY
KW - ANTI-immunoglobulin autoantibodies
KW - HEMAGGLUTININ
KW - LYMPHOCYTES
KW - MITOGENS
N1 - Accession Number: 13933580; Rollwagen, Florence M. 1 Mathieson, Bonnie J. 1 Asofsky, R. 1; Affiliation: 1: Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May82, Vol. 46 Issue 1, p49; Subject Term: T cells; Subject Term: CELL proliferation; Subject Term: FLUORIMETRY; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: HEMAGGLUTININ; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Froese, A.
AU - Helm, R. M.
AU - Conrad, D. H.
AU - Isersky, C.
AU - Ishizaka, T.
AU - Kulczycki Jr., A.
T1 - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines I. RECEPTORS ISOLATED BY IgE-SEPHAROSE AND IgE AND ANTI-IgE.
JO - Immunology
JF - Immunology
Y1 - 1982/05//
VL - 46
IS - 1
M3 - Article
SP - 107
EP - 116
PB - Wiley-Blackwell
SN - 00192805
AB - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of IgE-Sepharose or IgE and anti-IgE, and characterized by SDS-polyacrylamide gel electrophoresis. All cell lines were found to be associated with a receptor molecule (R) which could be isolated either with IgE-Sepharose or IgE and anti-IgE and a second receptor (H) which could only be isolated with the aid of IgE-Sepharose. The relative amounts of these two molecules, as isolated from surface iodinated cells, varied from one RBL cell line to the other and their apparent molecular weights were not identical on all cell lines. Since comparisons were made on the same gel using receptors isolated from cells labelled with different isotopes of iodine, differences in molecular weight must be considered as being intrinsic and not due to methodological variations. These results provide an explanation why differences were observed among receptors for IgE as characterized in various laboratories. In spite of the fact that the various RBL cell lines originated from the same chemically-induced tumour they have, over the years, undergone changes which are reflected in the receptors for IgE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL receptors
KW - IMMUNOGLOBULIN E
KW - CELL lines
KW - LEUKEMIA
KW - GEL electrophoresis
KW - CELL separation
KW - MOLECULES
N1 - Accession Number: 13933734; Froese, A. 1 Helm, R. M. 1 Conrad, D. H. 1 Isersky, C. 1 Ishizaka, T. 1 Kulczycki Jr., A. 1; Affiliation: 1: M.R.C. Group in Allergy Research, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada; Medical College of Virginia, Virginia Commonwealth University, Richmond, Va.; Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Md; Department of Medicine, The Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Md and The Department of Medicine, Washington University School of Medicine, St. Louis, Mo., U.S.A.; Source Info: May82, Vol. 46 Issue 1, p107; Subject Term: CELL receptors; Subject Term: IMMUNOGLOBULIN E; Subject Term: CELL lines; Subject Term: LEUKEMIA; Subject Term: GEL electrophoresis; Subject Term: CELL separation; Subject Term: MOLECULES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Froese, A.
AU - Helm, R. M.
AU - Conrad, D. H.
AU - Isersky, C.
AU - Ishizaka, T.
T1 - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines II. STUDIES WITH DIFFERENT ANTI-RECEPTOR ANTISERA.
JO - Immunology
JF - Immunology
Y1 - 1982/05//
VL - 46
IS - 1
M3 - Article
SP - 117
EP - 123
PB - Wiley-Blackwell
SN - 00192805
AB - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of various anti-receptor antisera, and characterized by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. Most antisera were shown to react with a receptor designated H and which, as shown previously, could be isolated by IgE-Sepharose but not by a combination of IgE and anti-IgE. Only two highly purified anti-receptor antibody preparations, which had been purified by adsorption to and elution from rat basophilic leukaemia cells, reacted primarily with a second kind of receptor molecule which had previously been designated R. Some indirect evidence was obtained which suggests that H is a highly immunogenic molecule. It was confirmed that the apparent molecular weight of H-like molecules varied on different RBL cell lines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL receptors
KW - IMMUNOGLOBULIN E
KW - CELL lines
KW - LEUKEMIA
KW - IMMUNE serums
KW - POLYACRYLAMIDE gel electrophoresis
KW - IMMUNOGENETICS
N1 - Accession Number: 13933902; Froese, A. 1 Helm, R. M. 1 Conrad, D. H. 1 Isersky, C. 1 Ishizaka, T. 1; Affiliation: 1: M.R.C. Group in Allergy Research, Department of Immunology, University of Manitoba, Winnipeg, Manitoba; Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia; Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, and the Department of Medicine, The Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Maryland, U.S.A.; Source Info: May82, Vol. 46 Issue 1, p117; Subject Term: CELL receptors; Subject Term: IMMUNOGLOBULIN E; Subject Term: CELL lines; Subject Term: LEUKEMIA; Subject Term: IMMUNE serums; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: IMMUNOGENETICS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Froese, A.
AU - Helm, R. M.
AU - Conrad, D. H.
AU - Isersky, C.
AU - Ishizaka, T.
T1 - Comparison of the receptors for IgE of various rat basophilic leukaemia cell lines II. STUDIES WITH DIFFERENT ANTI-RECEPTOR ANTISERA.
JO - Immunology
JF - Immunology
Y1 - 1982/05//
VL - 46
IS - 1
M3 - Article
SP - 117
EP - 123
SN - 00192805
AB - Receptors for IgE of rat basophilic leukaemia (RBL) cells, maintained in different laboratories were isolated by means of various anti-receptor antisera, and characterized by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. Most antisera were shown to react with a receptor designated H and which, as shown previously, could be isolated by IgE-Sepharose but not by a combination of IgE and anti-IgE. Only two highly purified anti-receptor antibody preparations, which had been purified by adsorption to and elution from rat basophilic leukaemia cells, reacted primarily with a second kind of receptor molecule which had previously been designated R. Some indirect evidence was obtained which suggests that H is a highly immunogenic molecule. It was confirmed that the apparent molecular weight of H-like molecules varied on different RBL cell lines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL receptors
KW - IMMUNOGLOBULIN E
KW - CELL lines
KW - LEUKEMIA
KW - IMMUNE serums
KW - POLYACRYLAMIDE gel electrophoresis
KW - IMMUNOGENETICS
N1 - Accession Number: 13933902; Froese, A. 1; Helm, R. M. 1; Conrad, D. H. 1; Isersky, C. 1; Ishizaka, T. 1; Source Information: May82, Vol. 46 Issue 1, p117; Subject: CELL receptors; Subject: IMMUNOGLOBULIN E; Subject: CELL lines; Subject: LEUKEMIA; Subject: IMMUNE serums; Subject: POLYACRYLAMIDE gel electrophoresis; Subject: IMMUNOGENETICS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Schoenberg, Ronald
T1 - Multiple Indicator Models: Estimation of Unconstrained Construct Means and Their Standard Errors.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1982/05//
VL - 10
IS - 4
M3 - Article
SP - 421
SN - 00491241
AB - Expressions are given for the calculation of the estimates and the standard errors of the estimates of the unconstrained means of the constructs in multiple indicator models. If the "reference" indicators - that is, the indicatory whose loadings are fixet to I., thereby identifying the variance of the construct and establishing its scale or units of measure are exclusive - that is, load only on the construct for which it is a "reference" - then the construct means are simply the means of the reference indicators. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methods & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FALLACIES (Logic)
KW - SCIENTIFIC errors
KW - ESTIMATION theory
KW - ESTIMATION bias
KW - DECISION making
KW - SOCIAL science research
N1 - Accession Number: 5864632; Schoenberg, Ronald 1; Source Information: May82, Vol. 10 Issue 4, p421; Subject: FALLACIES (Logic); Subject: SCIENTIFIC errors; Subject: ESTIMATION theory; Subject: ESTIMATION bias; Subject: DECISION making; Subject: SOCIAL science research; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - CHEVILLARD, C.
AU - SAAVEDRA, J. M.
T1 - High Angiotensin-Converting Enzyme Activity in the Neurohypophysis of Brattleboro Rats.
JO - Science
JF - Science
Y1 - 1982/05/07/
VL - 216
IS - 4546
M3 - Article
SP - 646
EP - 647
SN - 00368075
AB - The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats. The high activity level was reversed by vasopressin treatment. Conversely, angiotensin-converting enzyme activity was significantly lower in the anterior pituitary of B-rattleboro rats than in Long-Evans rats, and this activity level was not affected by vasopressin. These findings suggest an inverse relation between vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705418; CHEVILLARD, C. 1; SAAVEDRA, J. M. 1; Affiliations: 1: Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 5/ 7/1982, Vol. 216 Issue 4546, p646; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TWARDZIK, DANIEL R.
AU - TODARO, GEORGE J.
AU - MARQUARDT, HANS
AU - REYNOLDS JR., FRED H.
AU - STEPHENSON, JOHN R.
T1 - Transformation Induced by Abelson Murine Leukemia Virus Involves Production of a Polypeptide Growth Factor.
JO - Science
JF - Science
Y1 - 1982/05/21/
VL - 216
IS - 4548
M3 - Article
SP - 894
EP - 897
SN - 00368075
AB - Rat embryo fibroblasts transformed by Abelson murine leukemia virus (MuLV) produce and release a transforming growth factor (TGF). Production of this factor is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Transformation- defective mutants of Abelson MuLV do not transform cells, do not have their virus coded transforming gene product phosphorylated in tyrosine, and do not induce TGF production. Abelson AMuLV-induced TGF morphologically transforms cells in culture, competes with 125I-labeled epidermal growth factor (EGF) for binding to cell receptors, and induces phosphorylation of tyrosine acceptor sites in the 160,000-dalton EGF membrane receptor. After purification to homogeneity, Abelson virus-induced TGF migrates as a single polypeptide with an apparent size of 7400 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electro- phoresis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705532; TWARDZIK, DANIEL R. 1; TODARO, GEORGE J. 1; MARQUARDT, HANS 1; REYNOLDS JR., FRED H. 2; STEPHENSON, JOHN R. 3; Affiliations: 1: Laboratory of Viral Carcinogenesis, 69,000 National Cancer Institute, Frederick, Maryland 21701; 2: Carcinogenesis Intramural Research- Program, Frederick Cancer Research Facility, Frederick 21701; 3: Laboratory of Viral Carcinogenesis; Issue Info: 5/21/1982, Vol. 216 Issue 4548, p894; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ward, Douglas F.
AU - Gottesman, Max. E.
T1 - Suppression of Transcription Termination by Phage Lambda.
JO - Science
JF - Science
Y1 - 1982/05/28/
VL - 216
IS - 4549
M3 - Article
SP - 946
EP - 951
SN - 00368075
N1 - Accession Number: 84705540; Ward, Douglas F. 1; Gottesman, Max. E. 1; Affiliations: 1: Biochemical Genetics Section of Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p946; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SPRING, KENNETH R.
T1 - Ion Transport by Epithelia.
JO - Science
JF - Science
Y1 - 1982/05/28/
VL - 216
IS - 4549
M3 - Article
SP - 978
EP - 979
SN - 00368075
N1 - Accession Number: 84705557; SPRING, KENNETH R. 1; Affiliations: 1: Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p978; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TAMARKIN, LAWRENCE
AU - DANFORTH, DAVID
AU - LICHTER, ALAN
AU - DEMOSS, ERNEST
AU - COHEN, MICHAEL
AU - CHABNER, BRUCE
AU - LIPPMAN, MARC
T1 - Decreased Nocturnal Plasma Melatonin Peak in Patients with Estrogen Receptor Positive Breast Cancer.
JO - Science
JF - Science
Y1 - 1982/05/28/
VL - 216
IS - 4549
M3 - Article
SP - 1003
EP - 1005
SN - 00368075
AB - Plasma melatonin concentrations were determined over a period of 24 hours in 20 women with clinical stage I or II breast cancer. In ten of the patients, whose tumors were estrogen receptor positive, the nocturnal increase in plasma melatonin was much lower than that observed in eight control subjects. Women with the lowest peak concentration of melatonin had tumors with the highest concentrations of estrogen receptors. A significant correlation was found between the peak plasma melatonin concentration and the tumor estrogen receptor concentration in 19 of the patients. These data suggest that low nocturnal melatonin concentrations may indicate the presence of estrogen receptor positive breast cancer and could conceivably have etiologic significance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705571; TAMARKIN, LAWRENCE 1; DANFORTH, DAVID 2; LICHTER, ALAN 2; DEMOSS, ERNEST 2; COHEN, MICHAEL 2; CHABNER, BRUCE 2; LIPPMAN, MARC 2; Affiliations: 1: Intramural Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Medicine, Radiation, Surgery, and Clinical Pharmacology Branches, National Cancer Institute, Bethesda 20205; Issue Info: 5/28/1982, Vol. 216 Issue 4549, p1003; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rogers, M. J.
T1 - H-2b bound to egg lecithin liposomes: biochemical and functional properties.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/06//
VL - 48
IS - 3
M3 - Article
SP - 561
EP - 573
PB - Wiley-Blackwell
SN - 00099104
AB - Purified H-2b and H-2a molecules were bound to egg lecithin liposomes by a detergent dialysis procedure. Analysis of the liposomes indicated that only 30-50% of bound H-2b is oriented with the hydrophilic antigenic portion of the molecule toward the outside of the liposome. Saturation of the liposomes occurred at a ratio of 64 molecules of egg lecithin per molecule of H-2b. Liposomes containing H-2 molecules were capable of stimulating spleen cells from primed donors to produce specific, alloreactive, cytotoxic T lymphocytes in vitro. Stimulation was dependent on adherent cells present in the responder spleen cells. Optimal stimulation occurred with highly saturated liposomes and at a ratio of 4-8 µg of H-2b per 8 × 106 responder cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOLIPIDS
KW - CYTOPLASM
KW - LIPOSOMES
KW - BILAYER lipid membranes
KW - LECITHIN
KW - LYMPHOID tissue
KW - LEUCOCYTES
KW - T cells
N1 - Accession Number: 15990974; Rogers, M. J. 1; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: Jun1982, Vol. 48 Issue 3, p561; Subject Term: PHOSPHOLIPIDS; Subject Term: CYTOPLASM; Subject Term: LIPOSOMES; Subject Term: BILAYER lipid membranes; Subject Term: LECITHIN; Subject Term: LYMPHOID tissue; Subject Term: LEUCOCYTES; Subject Term: T cells; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olivecrona, Thomas
AU - Bengtsson, Gunilla
AU - Osborne Jr., James C.
T1 - Molecular Properties of Lipoprotein Lipase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1982/06//6/1/82
VL - 124
IS - 3
M3 - Article
SP - 629
EP - 633
PB - Wiley-Blackwell
SN - 00142956
AB - The monomer molecular size of bovine lipoprotein lipase was evaluated by sedimentation equilibrium measurements and by gel permeation chromatography in 6 M guanidinium chloride. To establish molecular weight unequivocally we determined the partial specific volume (v) experimentally. This was done by analyzing equllibrium concentration profiles from analytical ultracentrifugation in 6 M guanidinium chloride using buffers made up in H20 and 2H20. The combined results gave a v of 0.71 ± 0.007 ml/g and a molecular weight of 41700 ± 1000 for monomeric bovine lipoprotein lipase. This value did not change upon mild tryptic digestion; the elution volume upon gel permeation chromatography in 6 M guanidinium chloride was also unaffected by treatment with trypsin. Sedimentation equilibrium measurements of the trypsin-treated material in the presence of reducing agents gave limiting molecular weights of 19000 and 23000, demonstrating that mild trypsin digestion cleaved lipoprotein lipase into two polypeptide chains of similar size held together by disulfide bonds. Mild trypsin digestion also resulted in a loss of secondary structure as determined by circular dichroic measurements. Discussion centers around the correlation between these effects of trypsin on the molecular properties of lipoprotein lipase and the previously reported effects on the kinetic properties of the enzyme. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIPOPROTEIN lipase
KW - DIGESTIVE enzymes
KW - PANCREATIC secretions
KW - MOLECULAR weights
KW - CRYOSCOPY
KW - COLLOIDS
N1 - Accession Number: 15803474; Olivecrona, Thomas 1,2 Bengtsson, Gunilla 1,2 Osborne Jr., James C. 1,2; Affiliation: 1: Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland. 2: Department of Physiological Chemistry, University of Umeå; Source Info: 6/1/82, Vol. 124 Issue 3, p629; Subject Term: LIPOPROTEIN lipase; Subject Term: DIGESTIVE enzymes; Subject Term: PANCREATIC secretions; Subject Term: MOLECULAR weights; Subject Term: CRYOSCOPY; Subject Term: COLLOIDS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ribi, E.
AU - Granger, D. L.
AU - Milner, K. C.
AU - Yamamoto, K.
AU - Strain, S. M.
AU - Parker, R.
AU - Smith, R. W.
AU - Brehmer, W.
AU - Azuma, I.
T1 - Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.
JO - Immunology
JF - Immunology
Y1 - 1982/06//
VL - 46
IS - 2
M3 - Article
SP - 297
EP - 305
PB - Wiley-Blackwell
SN - 00192805
AB - Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIA
KW - TUBERCULOSIS
KW - ANTIGENS
KW - TUBERCULIN
KW - GRANULOMA
KW - IMMUNOLOGY
N1 - Accession Number: 13991040; Ribi, E. 1 Granger, D. L. 1 Milner, K. C. 1 Yamamoto, K. 2 Strain, S. M. 3 Parker, R. 3 Smith, R. W. 1 Brehmer, W. 4 Azuma, I. 2; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A 2: Institute of Immunological Science, Hokkaido University, Sapporo, Japan 3: Hamilton Biochemical Research Laboratory 4: Robert Koch Institute, Federal Health Office, 1000 Berlin 65, Germany; Source Info: Jun82, Vol. 46 Issue 2, p297; Subject Term: MYCOBACTERIA; Subject Term: TUBERCULOSIS; Subject Term: ANTIGENS; Subject Term: TUBERCULIN; Subject Term: GRANULOMA; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, K. T.
AU - Lee, C. J.
T1 - Immune response of neonates to pneumococcal polysaccharide-protein conjugate.
JO - Immunology
JF - Immunology
Y1 - 1982/06//
VL - 46
IS - 2
M3 - Article
SP - 333
EP - 342
PB - Wiley-Blackwell
SN - 00192805
AB - Immune responses were studied in adult and young mice exposed to pneumococcal 6A and 19F polysaccharides (PSs), as well as 19F PS conjugated to proteins, e.g. human immunoglobulin G (HIgG), pneumococcal R61 cell wall polypeptide, and bovine serum albumin (BSA). Significantly higher IgM and IgG2 antibody titres were induced in mice receiving 19F PS-protein conjugates than in the control group receiving 19F PS alone. Maternal immunization with 19F PS-HIgG conjugate elicited a low immune response in the offspring. However, when young mice from immunized mothers were given an additional dose of polysaccharide-protein conjugate, they gave an antibody response greater than that of mice not given additional immumogen. Similarly, young mice exposed to 14-valent pneumocoral vaccine during gestation produced higher antibody response to 6A and 19F PSs. Secondary immunization of 19F PS or PS-protein conjugate at 1 or 2 weeks after primary immunization did not enhance antibody formation but rather suppressed the immune response to that polysaccharide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - IMMUNOGLOBULIN G
KW - PNEUMOCOCCAL vaccine
KW - IMMUNE response
KW - ANIMAL models in research
KW - IMMUNOLOGY
N1 - Accession Number: 13991047; Lin, K. T. 1 Lee, C. J. 2; Affiliation: 1: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 2: Bureau of Biologics, National Institutes of Health Building 29, Bethesda, Maryland, U.S.A.; Source Info: Jun82, Vol. 46 Issue 2, p333; Subject Term: POLYSACCHARIDES; Subject Term: IMMUNOGLOBULIN G; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: IMMUNE response; Subject Term: ANIMAL models in research; Subject Term: IMMUNOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saxena, R. K.
AU - Saxena, Queen B.
AU - Adler, W. H.
T1 - Identity of effector cells participating in the reverse antibody-dependent cell-mediated cytotoxicity.
JO - Immunology
JF - Immunology
Y1 - 1982/06//
VL - 46
IS - 2
M3 - Article
SP - 459
EP - 464
PB - Wiley-Blackwell
SN - 00192805
AB - Our previous work has shown that antibody-coated mouse spleen cells express enhanced cytotoxic activity against some Fc-receptor-bearing target tumour cells by a mechanism which appears to be similar to an antibody-dependent cell-mediated cytotoxicity (ADCC) reaction with reversed polarity of the antibody bridge (R-ADCC). In this report we have shown that (i) the levels of basal natural killer (NK), ADCC and R-ADCC cytotoxic activities in mouse spleen cells are strongly correlated with each other, (b) simultaneous induction of ADCC and R-ADCC reactions does not result in an additive cytotoxic response, and (iii) YAC cells which do not bear Fc receptors and are highly sensitive to lysis by NK cells, can specifically and competitively inhibit the ADCC and R-ADCC reactions. These results suggest that the R-ADCC reaction may be mediated by the same effector cell population as mediates NK and ADCC reactions against tumour target cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - KILLER cells
KW - MACROPHAGES
KW - IMMUNOGLOBULINS
KW - CELL populations
KW - IMMUNOLOGY
N1 - Accession Number: 13991078; Saxena, R. K. 1 Saxena, Queen B. 1 Adler, W. H. 1; Affiliation: 1: Immunology Section, GRC, National Institute on Aging, National Institutes of Health, Maryland, U.S.A.; Source Info: Jun82, Vol. 46 Issue 2, p459; Subject Term: CELL-mediated cytotoxicity; Subject Term: KILLER cells; Subject Term: MACROPHAGES; Subject Term: IMMUNOGLOBULINS; Subject Term: CELL populations; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Hawley-Nelson, Pamela
AU - Yaar, Mina
AU - Martin, George H.
AU - Katz, Stephen I.
T1 - Laminin and Bullous Pemphigoid Antigen Are Distinct Basement Membrane Proteins Synthesized by Epidermal Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/06//
VL - 78
IS - 6
M3 - Article
SP - 456
EP - 459
SN - 0022202X
AB - We sought to determine if laminin, a high molecular weight glycoprotein of basement membrane, is synthesized by epidermal cells and whether it is distinct from bullous pemphigoid (BP) antigen, another high molecular weight-protein of basement membrane. By indirect immunofluorescence we detected laminin in cultures of Pam cells (a mouse keratinocyte cell line) and normal human epidermal cells. To directly demonstrate its biosynthesis, we labeled the cells with radioactive amino acids and then extracted the cell layers with nonionic detergent. Using immunoprecipitation followed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and fluorography to identify radiolabeled laminin, we could precipitate the 2 chains of laminin from cell culture medium and extracts of the cell layers. BP antigen, immunoprecipitated from the cells, did not comigrate with laminin on SDS-PAGE. In addition, BP antigen could be immunoprecipitated from cell extracts depleted of laminin, and conversely, laminin could be immunoprecipitated from cell extracts depleted of BP antigen. We conclude that laminin is synthesized by epidermal cells (specifically, keratinocytes) and is distinct from BP antigen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - ANTIGENS
KW - EPIDERMIS
KW - POLYACRYLAMIDE gel electrophoresis
KW - PROTEINS
KW - CELL culture
N1 - Accession Number: 12510132; Stanley, John R. 1 Hawley-Nelson, Pamela 2 Yaar, Mina 3 Martin, George H. 3 Katz, Stephen I. 2; Affiliation: 1: Department of Dermatology, Uniformed Services University of the Health Sciences, Maryland, U.S.A. 2: National Cancer Institute, Maryland, U.S.A. 3: National Institute of Dental Research of the National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun82, Vol. 78 Issue 6, p456; Subject Term: GLYCOPROTEINS; Subject Term: ANTIGENS; Subject Term: EPIDERMIS; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: PROTEINS; Subject Term: CELL culture; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510132
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chrousos, George P.
AU - Peck, Gary L.
AU - Gross, Earl G.
AU - Cutler Jr., Gordon B.
AU - Loriaux, D. Lynn
T1 - Adrenal Function in Women with Idiopathic Acne.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/06//
VL - 78
IS - 6
M3 - Article
SP - 468
EP - 471
SN - 0022202X
AB - The adrenal secretion of androgens was examined in 9 women (ages 19-39 yr) with postadolescent idiopathic acne and compared to age and sex-matched normal controls. Plasma dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (Δ4-A), cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48 hr ACTH infusion. The mean plasma and time-integrated plasma levels of the 3 adrenal androgens in patients with acne were 15-25% higher than normal controls, but the groups were not significantly different (p > .05). The plasma testosterone values, on the other hand, were similar in both groups. In addition, cortisol, 11-deoxycortisol and 17-hydroxyprogesterone basal plasma values and responses to ACTH in patients with acne were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic acne and is unlikely to be the sole cause of acne since many patients without acne have similar hormone levels. Increased sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROGENS
KW - ACNE
KW - RADIOIMMUNOASSAY
KW - TESTOSTERONE
KW - BLOOD plasma
KW - SEX hormones
N1 - Accession Number: 12510160; Chrousos, George P. 1 Peck, Gary L. 2 Gross, Earl G. 1 Cutler Jr., Gordon B. 2 Loriaux, D. Lynn 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, NIH, Bethesda, Maryland, U.S.A. 2: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Maryland, U.S.A.; Source Info: Jun82, Vol. 78 Issue 6, p468; Subject Term: ANDROGENS; Subject Term: ACNE; Subject Term: RADIOIMMUNOASSAY; Subject Term: TESTOSTERONE; Subject Term: BLOOD plasma; Subject Term: SEX hormones; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510160
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wurtz, Robert H.
AU - Goldberg, Michael E.
AU - Robinson, David Lee
T1 - Brain Mechanisms of Visual Attention.
JO - Scientific American
JF - Scientific American
Y1 - 1982/06//
VL - 246
IS - 6
M3 - Article
SP - 124
EP - 135
SN - 00368733
AB - The article focuses on the mechanism of brain for visual attention. Visual attention indicates the selection of a visual object from the visual field at the expense of other objects. The brain helps the eye to rotate in their sockets so that the analytic power of the fovea is directed toward objects of interest and make visual attention.
KW - Visual pathways
KW - Brain function localization
KW - Visual fields
KW - Vision
KW - Interest (Psychology)
KW - Eye
N1 - Accession Number: 23034050; Wurtz, Robert H. 1; Goldberg, Michael E. 1; Robinson, David Lee 1; Affiliations: 1: Laboratory of Sensorimotor Research, National Eye Institute.; Issue Info: Jun82, Vol. 246 Issue 6, p124; Subject Term: Visual pathways; Subject Term: Brain function localization; Subject Term: Visual fields; Subject Term: Vision; Subject Term: Interest (Psychology); Subject Term: Eye; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FISHER, MICHAEL S.
AU - KRIPKE, MARGARET L.
T1 - Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice.
JO - Science
JF - Science
Y1 - 1982/06/04/
VL - 216
IS - 4550
M3 - Article
SP - 1133
EP - 1134
SN - 00368075
AB - Exposure of mice to ultraviolet radiation results in the development of suppressor T lymphocytes in lymphoid organs, followed by the appearance of primary skin cancers. The presence or absence of these suppressor lymphocytes determines whether or not primary cancers will develop in the ultraviolet-irradiated skin. This demonstrates the importance of immunological regulatory pathways in carcinogenesis and provides an example of immunological surveillance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705635; FISHER, MICHAEL S. 1; KRIPKE, MARGARET L. 1; Affiliations: 1: Cancer Biology Program, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1133; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MARIANI, ANDREW P.
T1 - Biplexiform Cells: Ganglion Cells of the Primate Retina That Contact Photoreceptors.
JO - Science
JF - Science
Y1 - 1982/06/04/
VL - 216
IS - 4550
M3 - Article
SP - 1134
EP - 1136
SN - 00368075
AB - Golgi-impregnated biplexiform cells of the macaque retina are neurons with cell bodies in the ganglion cell layer, an axon in the nerve fiber layer, and dendrites in the inner plexiform layer that are postsynaptic to amacrine cell processes and bipolar cell axon terminals. In these features they resemble conventional ganglion cells, but they also have processes that arisefrom the main dendritic arborization, extend to the outer plexiform layer, and are postsynaptic to rod photoreceptor terminals as central elements at the ribbon synaptic complex. However, ordinary retinal ganglion cell dendrites ramify in the inner plexiform layer and do not contact photoreceptors. Thus, biplexiform cells represent a previously undescribed class of neuron, part of whose synaptic input could bypass the commonly described interneuron circuitry of the vertebrate retina. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705636; MARIANI, ANDREW P. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1134; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GROFFEN, JOHN
AU - HEISTERKAMP, NORA
AU - GROSVELD, FRANK
AU - DE VEN, WIM VAN
AU - STEPHENSON, J. R.
T1 - Isolation of Human Oncogene Sequences (v-fes Homolog) from a Cosmid Library.
JO - Science
JF - Science
Y1 - 1982/06/04/
VL - 216
IS - 4550
M3 - Article
SP - 1136
EP - 1138
SN - 00368075
AB - To define the human homolog (or homologs) of transforming sequences (v-fes gene) common to Gardner (GA) and Snyder Theilen (ST) isolates of feline sarcoma virus (FeSV), a representative library of human lung carcinoma DNA in a cosmid vector system was constructed. Three cosmid clones were isolated containing GAIST FeSV v-fes homologous cellular sequences, within 32- to 42-kilobase cellular inserts representing 56 kilobases of contiguous human cellular DNA. Sequences both homologous to, and colinear with, GA or ST FeSV v-fes are distributed discontinuously over a region of up to 9.5 kilobases and contain a minimum of three regions of nonhomology representing probable introns. A thymidine kinase selection system was used to show that, upon transfection to RAT-2 cells, the human c-fes sequence lacked detectable transforming activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705637; GROFFEN, JOHN 1; HEISTERKAMP, NORA 1; GROSVELD, FRANK 2; DE VEN, WIM VAN 3; STEPHENSON, J. R. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Gene Structure and Expression, Medical Research, Council, London NW7 IAA; 3: Carcinogenesis and Intramural Program, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 6/ 4/1982, Vol. 216 Issue 4550, p1136; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BATTELLE, B.-A.
AU - EVANS, J. A.
AU - CHAMBERLAIN, S. C.
T1 - Efferent Fibers to Limulus Eyes Synthesize and Release Octopamine.
JO - Science
JF - Science
Y1 - 1982/06/11/
VL - 216
IS - 4551
M3 - Article
SP - 1250
EP - 1252
SN - 00368075
AB - Octopamine synthesized in vitro from tyrnrnine by Limulus lateral and ventral eyes was located by light microscopic and electron microscopic autoradiography in efferent fibers which innervate ventral photoreceptors and lateral eye ommatidia. Newly synthesized octopamine was released from efferent fibers in response to depolarization in high concentrations of potassium. We propose that octopamine is a neurotransmitter of efferent fibers that may modulate basic retinal processes such as photoreceptor sensitivity, photomechanical movements, and photoreceptive membrane turnover. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705683; BATTELLE, B.-A. 1; EVANS, J. A. 1; CHAMBERLAIN, S. C. 2; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; 2: Institute for Sensory Research, Syracuse University, Syracuse, New York 13210; Issue Info: 6/11/1982, Vol. 216 Issue 4551, p1250; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 84001152
T1 - Heterozygote detection in cystinosis, using leukocytes exposed to cystine dimethyl ester.
AU - Steinherz, Reuben
AU - Tietze, Frank
AU - Triche, Timothy
AU - Modesti, Andrea
AU - Gahl, William A.
AU - Schulman, Joseph D.
AU - Steinherz, R
AU - Tietze, F
AU - Triche, T
AU - Modesti, A
AU - Gahl, W A
AU - Schulman, J D
Y1 - 1982/06/17/
N1 - Accession Number: 84001152. Language: English. Entry Date: In Process. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Cysteine
KW - Leukocytes -- Metabolism
KW - Metabolism, Inborn Errors
KW - Genetic Techniques -- Methods
KW - Cysteine -- Metabolism
KW - Male
KW - Female
KW - Metabolism, Inborn Errors -- Diagnosis
KW - Radioisotopes
SP - 1468
EP - 1470
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 306
IS - 24
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - From the Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, the Section on Intermediary Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health. Address reprint requests to Dr. Schulman at Bldg. 10, Rm. 8C429, National Institutes of Health, Bethesda, MD 20205.
U2 - PMID: 7078591.
DO - 10.1056/NEJM198206173062407
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - BURGDORFER, WILLY
AU - BARBOUR, ALAN G.
AU - HAYES, STANLEY F.
AU - BENACH, JORGE L.
AU - GRUNWALDT, EDGAR
AU - DAVIS, JEFFREY P.
T1 - Lyme Disease--A Tick-Borne Spirochetosis?
JO - Science
JF - Science
Y1 - 1982/06/18/
VL - 216
IS - 4552
M3 - Article
SP - 1317
EP - 1319
SN - 00368075
AB - A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705720; BURGDORFER, WILLY 1; BARBOUR, ALAN G. 2; HAYES, STANLEY F. 3; BENACH, JORGE L. 4,5; GRUNWALDT, EDGAR 6; DAVIS, JEFFREY P. 7; Affiliations: 1: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 2: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories; 3: Rocky Mountain Operations Branch, Rocky Mountain Laboratories; 4: State of New York Department of Health, State University ofNew York, Stony Brook 11794; 5: Department of Pathology, State University of New York, Stony Brook 11794; 6: 44 South Ferry Road Shelter Island, New York 11964; 7: Department of Health and Social Services, Madison, Wisconsin 53701; Issue Info: 6/18/1982, Vol. 216 Issue 4552, p1317; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RUSHLOW, KEITH E.
AU - LAUTENBERGER, JAMES A.
AU - PAPAS, TAKIS S.
AU - BALUDA, MARCEL A.
AU - PERBAL, BERNARD
AU - CHIRIKJIAN, JACK G.
AU - REDDY, E. PREMKUMAR
T1 - Nucleotide Sequence of the Transforming Gene of Avian Myeloblastosis Virus.
JO - Science
JF - Science
Y1 - 1982/06/25/
VL - 216
IS - 4553
M3 - Article
SP - 1421
EP - 1423
SN - 00368075
AB - Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essentialfor leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 armino acids with a molecular weight of approximately 30,000. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705765; RUSHLOW, KEITH E. 1; LAUTENBERGER, JAMES A. 1; PAPAS, TAKIS S. 1; BALUDA, MARCEL A. 2; PERBAL, BERNARD 2; CHIRIKJIAN, JACK G. 3; REDDY, E. PREMKUMAR 4; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 2020; 2: UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, California 90024; 3: Georgetown Medical Center, Washington, D.C.; 4: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 2020; Issue Info: 6/25/1982, Vol. 216 Issue 4553, p1421; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STERNBERG, D. E.
AU - KAMMEN, D. P. VAN
AU - LERNER, P.
AU - BUNNEY, W. E.
T1 - Schizophrenia: Dopamine β-Hydroxylase Activity and Treatment Response.
JO - Science
JF - Science
Y1 - 1982/06/25/
VL - 216
IS - 4553
M3 - Article
SP - 1423
EP - 1425
SN - 00368075
AB - Cerebrospinal fluid levels of dopamine β-hydroxylase, found to be relatively constant over time in individual patients, were significantly lower in schizophrenic patients who became nonpsychotic during neuroleptic treatment than in those who remained psychotic. Dopamine 3-hydroxylase activity may delineate a subgroup ofpatients who have a dopamine-sensitive brain disorder. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705766; STERNBERG, D. E. 1; KAMMEN, D. P. VAN 2; LERNER, P. 2; BUNNEY, W. E. 2; Affiliations: 1: Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06519; 2: Section on Neuropsychopharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 6/25/1982, Vol. 216 Issue 4553, p1423; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sutnick, Alton I.
AU - Saunders, Joseph F.
AU - Puchkov, Yuri I.
T1 - Cancer Control in India: A Multinational Approach Involving the USA and the USSR.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/07//
VL - 72
IS - 7
M3 - Article
SP - 714
EP - 717
PB - American Public Health Association
SN - 00900036
AB - Based on a long-standing cooperation in medicine and public health between the United States and the Soviet Union, and on the potential contributions to be made by scientists from both of these countries, the World Health Organization invited an American-Soviet collaborative team to recommend a cancer control program for the Government of India. The consultants defined the importance of cancer of the cervix uteri and of the oral cavity, which comprise one-half of India's cancer cases, as the basis for a cancer control program. They recommended incorporation of cancer control functions into the organizational structure of the Ministry of Health as well as specific recommendations in education, prevention, and early detection, diagnosis, treatment, and epidemiologic studies. This mission underscores the value of multinational cooperation on health care problems that are faced in common by the United States, the Soviet Union, and other countries of the world. In addition it serves as a basis for international friendship and understanding in the context of mutually productive activities which may provide a benefit for all nations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - MEDICAL care
KW - CANCER prevention
KW - CERVICAL cancer
KW - PREVENTIVE medicine
KW - SCIENTISTS
KW - UNITED States
KW - SOVIET Union
KW - WORLD Health Organization
N1 - Accession Number: 4950469; Sutnick, Alton I. 1,2 Saunders, Joseph F. 3 Puchkov, Yuri I. 4; Affiliation: 1: Senior Vice President, Health Affairs, 3300 Henry Avenue, Philadelphia, PA 19129 2: Dean, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, PA 19129 3: Deputy Director, Office of International Affairs, National Cancer Institute, NIH, Bethesda, MD 4: Chief, Department of International Scientific Relations, Cancer Research Center, USSR Academy of Medical Sciences, Moscow; Source Info: Jul1982, Vol. 72 Issue 7, p714; Subject Term: PUBLIC health; Subject Term: MEDICAL care; Subject Term: CANCER prevention; Subject Term: CERVICAL cancer; Subject Term: PREVENTIVE medicine; Subject Term: SCIENTISTS; Subject Term: UNITED States; Subject Term: SOVIET Union; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yanagihara, R. H.
T1 - HLA AND CLINICAL DISORDERS.
JO - BioScience
JF - BioScience
Y1 - 1982/07//Jul/Aug1982
VL - 32
IS - 7
M3 - Book Review
SP - 627
EP - 627
SN - 00063568
AB - The article reviews the book "HLA in Endocrine and Metabolic Disorders," edited by Nadir R. Farid.
KW - HLA histocompatibility antigens
KW - Nonfiction
KW - Farid, Nadir R.
KW - Hla in Endocrine & Metabolic Disorders (Book)
N1 - Accession Number: 28050152; Yanagihara, R. H. 1; Affiliations: 1 : National Institutes of Health National Institute on Aging Gerontology Research Center Baltimore City Hospitals Baltimore, MD 21224; Source Info: Jul/Aug1982, Vol. 32 Issue 7, p627; Subject Term: HLA histocompatibility antigens; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 525
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Luster, M. I.
AU - Dean, J. H.
AU - Boorman, G. A.
AU - Dieter, M. P.
AU - Hayes, H. T.
T1 - Immune functions in methyl and ethyl carbamate treated mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/07//
VL - 49
IS - 1
M3 - Article
SP - 223
EP - 230
PB - Wiley-Blackwell
SN - 00099104
AB - Female B6C3F1 hybrid mice (5-7 weeks of age) were given methyl or ethyl carbamate over a 2 week period and subsequently examined for alterations in various immunological parameters. Exposure to methyl carbamate, a non-carcinogen, did not cause any alterations in the parameters examined. In contrast, exposure to the multipotential carcinogen, ethyl carbamate (urethan) at tumourigenic dosages caused severe myelotoxicity at all dosage levels. Related to the myelotoxicity was a marked depression of natural killer cell activity. Other parameters including susceptibility to tumour cell challenge, humoral immunity, cellular immunity and macrophage function were less affected. These studies indicate that non-toxic, but carcinogenic dosages of urethan, have profound but selective effects on the immune system which can be related to alterations in bone marrow functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URETHANE
KW - CARCINOGENS
KW - IMMUNE response
KW - MICE as laboratory animals
KW - KILLER cells
KW - BONE marrow
KW - CELLULAR immunity
N1 - Accession Number: 16253211; Luster, M. I. 1 Dean, J. H. 1 Boorman, G. A. 1 Dieter, M. P. 1 Hayes, H. T. 1; Affiliation: 1: National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.; Source Info: Jul1982, Vol. 49 Issue 1, p223; Subject Term: URETHANE; Subject Term: CARCINOGENS; Subject Term: IMMUNE response; Subject Term: MICE as laboratory animals; Subject Term: KILLER cells; Subject Term: BONE marrow; Subject Term: CELLULAR immunity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roder, J. C.
AU - Haliotis, Tina
AU - Laing, L.
AU - Kozbor, Danuta
AU - Rubin, P.
AU - Pross, H.
AU - Boxer, L. A.
AU - White, J. G.
AU - Fauci, A. S.
AU - Mostowski, H.
AU - Matheson, D. S.
T1 - Further studies of natural killer cell function in Chediak-Higashi patients.
JO - Immunology
JF - Immunology
Y1 - 1982/07//
VL - 46
IS - 3
M3 - Article
SP - 555
EP - 560
PB - Wiley-Blackwell
SN - 00192805
AB - Spontaneous natural killer (NK) activity and antibody-dependent cellular cytotoxicity (ADCC) of blood lymphocytes against five human tumour cell lines (K562, Molt-4, HL-60, Chang, Daudi) and three mouse tumour lines (YAC, P815, RBL-5) were ten- to 100-fold lower than normal in six patients with Chediak-Higashi (CH) disease. NK and ADCC were defective at 4 hr, and less so at 18 hr. The NK activity in normals and CH patients was mediated in part by FcR+, E- effector cells. ADCC against human erythrocytes was normal in CH patients, as were lectin-dependent cytolysis and mixed lymphocyte proliferative responses. Phagocytosis of antibody-coated ox erythrocytes was normal in CH patients as well, These observations confirm that the CH syndrome is associated with a profound and selective defect in NK and ADCC activity against tumour cells, whereas other mononuclear cell-mediated functions are normal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - CELL-mediated cytotoxicity
KW - CANCER cells
KW - IMMUNOCOMPETENT cells
KW - ANTIGEN-antibody reactions
KW - IMMUNOLOGY
N1 - Accession Number: 13953455; Roder, J. C. 1 Haliotis, Tina 1 Laing, L. 1 Kozbor, Danuta 1 Rubin, P. 1 Pross, H. 1 Boxer, L. A. 2 White, J. G. 3 Fauci, A. S. 4 Mostowski, H. 4 Matheson, D. S. 5; Affiliation: 1: Queen's University, Kingston, Ontario, Canada 2: Division of Paediatric Hematology-Oncology, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, West Michigan St., Indianapolis, Indiana 3: Department of Paediatrics, University of Minnesota, School of Medicine, Minneapolis, Minnesota 4: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland 5: Faculty of Medicine, University of Calgary, N.W., Calgary, Alberta, Canada; Source Info: Jul82, Vol. 46 Issue 3, p555; Subject Term: KILLER cells; Subject Term: CELL-mediated cytotoxicity; Subject Term: CANCER cells; Subject Term: IMMUNOCOMPETENT cells; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abdi, Hamida B.
AU - Simons, Margaret A.
AU - Young-Cooper, Glendowlyn O.
AU - Mage, Rose G.
T1 - Expression of kappa chain allotypes at the cell surface and in serum immunoglobulins of normal and allotype-suppressed heterozygous rabbits.
JO - Immunology
JF - Immunology
Y1 - 1982/07//
VL - 46
IS - 3
M3 - Article
SP - 661
EP - 669
PB - Wiley-Blackwell
SN - 00192805
AB - The kappa light chain allotypes b4 and b5 were measured in the serum and on the surfaces of peripheral blood lymphocytes of normal and allotype-suppressed heterozygous rabbits. Surface immunoglobulins (sIg) were detected by fluorescence microscopy and additional quantitative data were obtained by flow microfluorometry. Although a few b5-suppressed animals had no b5 in serum or on cell surfaces for years, most b5-suppressed and all b4-suppressed animals studied had some cells with sIg of the suppressed type by I year of age. In suppressed animals the level of serum Ig remained depressed throughout life but cells with sIg appeared in disproportionately large numbers. The effect was particularly striking in those animals suppressed for the b4 type. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN allotypes
KW - RABBITS as laboratory animals
KW - CELL membranes
KW - IMMUNOGLOBULINS
KW - IMMUNOSUPPRESSION
KW - IMMUNOLOGY
N1 - Accession Number: 13954056; Abdi, Hamida B. 1 Simons, Margaret A. 1 Young-Cooper, Glendowlyn O. 1 Mage, Rose G. 1; Affiliation: 1: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82, Vol. 46 Issue 3, p661; Subject Term: IMMUNOGLOBULIN allotypes; Subject Term: RABBITS as laboratory animals; Subject Term: CELL membranes; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNOLOGY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hearing, Vincent J.
AU - Korner, Ann M.
AU - Pawelek, John M.
T1 - New Regulators of Melanogenesis Are Associated with Purified Tyrosinase Isozymes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/07//
VL - 79
IS - 1
M3 - Article
SP - 16
EP - 18
SN - 0022202X
AB - Three new regulatory factors in the melanogenesis pathway were recently described: dopachrome conversion factor accelerates the conversion of dopachrome to 5,6-dihydroxyindole; indole conversion factor accelerates the conversion of 5,6-dihydroxyindole into melanin; and indole blocking factor retards the conversion of 5,6- dihydroxyindole into melanin. Exposure of wild-type Cloudman melanoma cells in culture to melanotropin (MSH) removes blocking factor activity and increases indole conversion factor activity. The chemical nature of the factors has not yet been determined. In this report we demonstrate that highly purified isozymes of tyrosinase from C57B1/6N murine hair bulbs and B16 murine melanoma are closely associated with conversion and blocking factor activities. The soluble isozymes T1, T2, and T3 contain blocking factor activity, while isozyme T4, the major tyrosinase species found in melanosomes, contains activity that accelerates melanin formation from dopachrome. The results suggest that melanogenesis is regulated by the association of these different factors with the specific tyrosinase isozymes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANOGENESIS
KW - PHENOL oxidase
KW - ISOENZYMES
KW - MSH (Hormone)
KW - INDOLE
KW - ANIMAL pigments
N1 - Accession Number: 12510422; Hearing, Vincent J. 1 Korner, Ann M. 2 Pawelek, John M. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, U.S.A.; Source Info: Jul82, Vol. 79 Issue 1, p16; Subject Term: MELANOGENESIS; Subject Term: PHENOL oxidase; Subject Term: ISOENZYMES; Subject Term: MSH (Hormone); Subject Term: INDOLE; Subject Term: ANIMAL pigments; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510422
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauder, Daniel N.
AU - Carter, Charles S.
AU - Katz, Stephen I.
AU - Oppenheim, Joost J.
T1 - Epidermal Cell Production of Thymocyte Activating Factor (ETAF).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/07//
VL - 79
IS - 1
M3 - Article
SP - 34
EP - 39
SN - 0022202X
AB - Since epidermal Langerhans cells share many of the surface marker characteristics and functions of cells of the monocyte-macrophage series, we sought to determine whether Langerhans cells, like macrophages, produce Interleukin 1 (IL-1), formerly called lymphocyte activating factor. Heterogenous suspensions of murine epidermal cells were cultured for 3 days with or without various stimulants and their cell-free supernatants were tested for IL-1 activity in a thymocyte proliferation assay. Significant augmentation of lectin induced thymocyte proliferation was produced by the supernatants of these cultures. However, when epidermal cells were depleted of Langerhans cells by treating with anti-la anti-serum and complement, the supernatants still produced significant augmentation. As the augmenting activity was due to a factor found in the supernatants of epidermal cell suspensions devoid of Langerhans cells the factor is called Epidermal Cell Thymocyte Activating Factor (ETAF). ETAF was produced by unstimulated epidermal cells, but significantly more was produced by epidermal cells that were incubated with phorbol myristic acetate, a low molecular weight tumor promoting agent or muramyl dipeptide, the synthetic analog of the cell wall of mycobacterium smegmatis. ETAF production was reduced by X-irradiation and was completely abolished when protein synthesis was inhibited. The molecular weight of this factor was approximately 15,000 dalton, which is similar to the molecular weight of macrophage derived IL-1; its heat stability and pH stability were similar to that of IL-1. ETAF, like IL-1 also enhanced lymphocyte production of Interleukin 2 (IL-2). The data indicate that epidermal cells, devoid of Langerhans cells, are capable of producing factors with IL-1 like activity and may thereby modulate immune responses locally in the skin and perhaps systemically. [ABSTRACT FROM AUTHOR]
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KW - LANGERHANS cells
KW - EPIDERMAL growth factor
KW - CELL surface antigens
KW - MACROPHAGES
KW - INTERLEUKIN-1
KW - CELL suspensions
KW - MYCOBACTERIUM
N1 - Accession Number: 12510569; Sauder, Daniel N. 1,2 Carter, Charles S. 1,2 Katz, Stephen I. 1,2 Oppenheim, Joost J. 1,2; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82, Vol. 79 Issue 1, p34; Subject Term: LANGERHANS cells; Subject Term: EPIDERMAL growth factor; Subject Term: CELL surface antigens; Subject Term: MACROPHAGES; Subject Term: INTERLEUKIN-1; Subject Term: CELL suspensions; Subject Term: MYCOBACTERIUM; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12510569
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garwood, M.
AU - Engel, B. T.
AU - Caprioiti, R.
T1 - Autonomic Nervous System Function and Aging: Response Specificity.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1982/07//
VL - 19
IS - 4
M3 - Article
SP - 378
EP - 385
SN - 00485772
AB - Age differences in autonomic nervous system response patterns were investigated to determine if there was an age-related increase in the tendency to respond to multiple stimuli with a consistent response hierarchy (individual consistency). Five stimuli were administered in a Latin Square design-mental arithmetic, cold pressor, isometric exercise, comic slide, and time estimation. A warning tone was presented before each stimulus. Physiological measures included heart rate, systolic and diastolic blood pressures, skin potential, breathing rate, and digital blood flow. To compare responses in different systems, responses were standardized according to the formula, Z = [50 + 10(X - M)]/σ, where Z is the standardized score, X is the difference between stimulation and warning levels, M is the avenge response for that system, and σ is the square root of the mean square for error from the analysis of variance computed for each response system. A matrix was generated lot each subject which Included his Z scores from the six response systems for the five stimuli. Intraclass correlations were then computed. Individual consistency significantly Increased with increasing age (r = .33, p<.005). [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTONOMIC nervous system
KW - AGING
KW - MENTAL arithmetic
KW - TIME perception
KW - HEART beat
KW - BLOOD pressure
KW - Aging
KW - Autonomic nervous system
KW - Response specificity
N1 - Accession Number: 14180133; Garwood, M. 1 Engel, B. T. 2 Caprioiti, R. 3; Affiliation: 1: Gerontology Research Center (Baltimore), National Institute on Aging. 2: Baltimore City Hospital, Baltimore. 3: National Institutes of Health, PHS, U. S. Department of Human Health Services, Bethesda.; Source Info: Jul1982, Vol. 19 Issue 4, p378; Subject Term: AUTONOMIC nervous system; Subject Term: AGING; Subject Term: MENTAL arithmetic; Subject Term: TIME perception; Subject Term: HEART beat; Subject Term: BLOOD pressure; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Autonomic nervous system; Author-Supplied Keyword: Response specificity; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-8986.ep14180133
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Levy, Robert I.
AU - Moskowitz, Jay
T1 - Cardiovascular Research: Decades of Progress, a Decade of Promise.
JO - Science
JF - Science
Y1 - 1982/07/09/
VL - 217
IS - 4555
M3 - Article
SP - 121
EP - 129
SN - 00368075
AB - Mortality due to cardiovascular diseases has decreased more than 30 percent in the last 30 years, and this decline has accelerated so much that over 60 percent of it has occurred between 1970 and 1980. The past and present contributions of advances in cardiovascular research to this decline are reviewed. Although there have been significant research accomplishments, too many people still die of heart and blood vessel diseases. Continued emphasis must be placed on research in the areas of etiology and pathogenesis, on validating potentially beneficial research hypotheses, and on the translation and dissemination of research results to the health care practitioner and the public. Only then can our long-term goal, the prevention of cardiovascular disease, be fully realized. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 88017027; Levy, Robert I. 1; Moskowitz, Jay 2; Affiliations: 1: Vice President for Health Sciences, Tufts University, Boston, Massachusetts 02111; 2: Associate Director for Scientific Program Operation, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 7/ 9/1982, Vol. 217 Issue 4555, p121; Number of Pages: 9p; Document Type: Article
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ER -
TY - JOUR
AU - Tolstoshev, Paul
AU - Crystal, Ronald G.
T1 - The Collagen Alpha-2 Chain Gene.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/07/15/
VL - 79
M3 - Article
SP - 60s
EP - 64s
SN - 0022202X
AB - A number of DNA sequences specific for collagen messenger RNAs and genes have been isolated, cloned in bacterial plasmids or bacteriophage, and studied in detail. Such sequences have been used to study regulatory mechanisms underlying the production of type I collagen in fibroblasts in culture, fibroblasts after viral transformation, and in tissues and organs during embryonic and fetal development. It is clear that a variety of mechanisms, transcriptional, translational and post-translational, are used by cells to regulate collagen production. The study of isolated collagen gene fragments coding for the α2 collagen chain in sheep and chick have shown that these genes are very large, and are interrupted by as many as 50 intervening sequences. Additionally, the structure of the genes in the regions coding for the helical regions of the protein provides evidence that collagen genes may have arisen from the reduplication of a DNA segment containing a primordial collagen gene sequence. The availability of specific cloned collagen gene sequences will allow the precise chromosomal location of the collagen genes as well as the number and the linkage relationships between these genes, in addition, genetic disorders of connective tissue where alterations in collagen structure are implicated will now be amenable to analysis at the DNA level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLAGEN
KW - GENES
KW - NUCLEOTIDE sequence
KW - MESSENGER RNA
KW - BACTERIOPHAGES
KW - GENETIC disorders
N1 - Accession Number: 12545778; Tolstoshev, Paul 1 Crystal, Ronald G. 1; Affiliation: 1: Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesada, Maryland, U. S. A.; Source Info: Jul82Supplement, Vol. 79, p60s; Subject Term: COLLAGEN; Subject Term: GENES; Subject Term: NUCLEOTIDE sequence; Subject Term: MESSENGER RNA; Subject Term: BACTERIOPHAGES; Subject Term: GENETIC disorders; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12545778
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Woodley, David T.
AU - Katz, Stephen I.
AU - Martin, George R.
T1 - Structure and Function of Basement Membrane.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/07/15/
VL - 79
M3 - Article
SP - 69s
EP - 72s
SN - 0022202X
AB - Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro α1(IV) (Mr185,000) and pro α2(IV) (Mr 170,000) chains. As opposed to the fibrillar pattern seen with other collagens, the type IV collagen molecules are thought to be arranged in a honey-comb or reticular pattern which provides the major structural element of the basement membrane. Consistent with this model, type IV collagen has been localized to the basement membrane lamina densa, a nonfibrillar structure. Laminin is a large (Mr= 1,000,000) noncollagenous glycoprotein with chains of 200,000 and 400,000 daltons. It has been localized to the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. A heparan sulfate proteoglycan has also been identified in the basement membrane. Its biological function may be to restrict the penetration of anionic macromolecules through the basement membrane. In contrast to the above-mentioned components which are found in all tissue basement membranes, bullous pemphigoid antigen is only found in certain basement membranes, mostly those of stratified squamous epithelia. Bullous pemphigoid antigen is a protein, synthesized by keratinocytes in culture, with disulfide-linked chains (Mr=220,000). By immunoelectron microscopy, it is localized in the lamina lucida of epidermal basement membrane and is closely associated with the basal cell surface. Its biological function is not known, but could involve epidermal basal cell-substrate interactions which occur when basal cells re-epithelialize wounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BASAL lamina
KW - COLLAGEN
KW - ANTIGENS
KW - EPITHELIUM
KW - PROTEOGLYCANS
KW - GLYCOPROTEINS
N1 - Accession Number: 12545830; Stanley, John R. 1 Woodley, David T. 2 Katz, Stephen I. 3 Martin, George R. 2; Affiliation: 1: Department of Dermatology, Uniformed Services University of Health Sciences, Bethesda, Maryland. 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland. 3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul82Supplement, Vol. 79, p69s; Subject Term: BASAL lamina; Subject Term: COLLAGEN; Subject Term: ANTIGENS; Subject Term: EPITHELIUM; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12545830
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rennard, Stephen I.
AU - Stier, Larue E.
AU - Crystal, Ronald G.
T1 - Intracellular Degradation of Newly Synthesized Collagen.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1982/07/15/
VL - 79
M3 - Article
SP - 77s
EP - 82s
SN - 0022202X
AB - The in intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLAGEN
KW - EXTRACELLULAR matrix proteins
KW - DIABETES
KW - CONNECTIVE tissues
KW - SCURVY
KW - EXTRACELLULAR matrix
N1 - Accession Number: 12545844; Rennard, Stephen I. 1 Stier, Larue E. 1 Crystal, Ronald G. 1; Affiliation: 1: Pulmonary Branch, National Heart, Lung and Blood Institute Bethesda, Maryland, U.S.A.; Source Info: Jul82Supplement, Vol. 79, p77s; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: DIABETES; Subject Term: CONNECTIVE tissues; Subject Term: SCURVY; Subject Term: EXTRACELLULAR matrix; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12545844
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TRIGG, MICHAEL E.
AU - POPLACK, DAVID G.
T1 - Transplantation of Leukemic Bone Marrow Treated with Cytotoxic Antileukemic Antibodies and Complement.
JO - Science
JF - Science
Y1 - 1982/07/16/
VL - 217
IS - 4556
M3 - Article
SP - 259
EP - 261
SN - 00368075
AB - The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003741; TRIGG, MICHAEL E. 1; POPLACK, DAVID G. 2; Affiliations: 1: Department of Pediatrics, University of Wisconsin, Madison 53792; 2: Pediatric Oncology Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 7/16/1982, Vol. 217 Issue 4556, p259; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - NESTLER, ERIC J.
AU - ZATZ, MARTIN
AU - GREENGARD, PAUL
T1 - A Diurnal Rhythm in Pineal Protein 1 Content Mediated by ß-Adrenergic Neurotransmission.
JO - Science
JF - Science
Y1 - 1982/07/23/
VL - 217
IS - 4557
M3 - Article
SP - 357
EP - 359
SN - 00368075
AB - A diurnal rhythm was found in the total amount of the neuron-specific phosphoprotein protein I in rat pinealocytes. ß-Adrenergic neurotransmission appears to be the mechanism regulating the amount of pineal protein I in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712020; NESTLER, ERIC J. 1; ZATZ, MARTIN 2; GREENGARD, PAUL 3; Affiliations: 1: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Pharmacology, Yale University School of Medicine; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p357; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TALMADGE, JAMES E.
AU - WOLMAN, SANDRA R.
AU - FIDLER, ISAIAH J.
T1 - Evidence for the Clonal Origin of Spontaneous Metastases.
JO - Science
JF - Science
Y1 - 1982/07/23/
VL - 217
IS - 4557
M3 - Article
SP - 361
EP - 363
SN - 00368075
AB - A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastdses were isolated from different animals, established in culture as individual lines, and then karyotyped. Within -certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the tells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712022; TALMADGE, JAMES E. 1; WOLMAN, SANDRA R. 2; FIDLER, ISAIAH J. 3; Affiliations: 1: Cancer Metastasis, Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; 2: New York University Medical Center, Department of Pathology, School of Medicine, New York 10016; 3: Cancer Metastasis and Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p361; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HANNA JR., MICHAEL G.
AU - KEY, MARC E.
T1 - Immunotherapy of Metastases Enhances Subsequent Chemotherapy.
JO - Science
JF - Science
Y1 - 1982/07/23/
VL - 217
IS - 4557
M3 - Article
SP - 367
EP - 369
SN - 00368075
AB - In many multimodal therapies of cancer, postsurgical chemotherapy is administered before immunotherapy for treatment of micrometastatic disease. This sequence may not be the most efficacious. Experiments in which strain 2 guinea pigs bearing syngeneic L1O hepatocarcinomas were given immunotherapy showed that infiltrating immune effector cells not only were tumoricidal but disrupted the characteristically compact structure of metastatic foci. When cytotoxic drugs were administered at the peak of this inflammatory response, the survival rate of the guinea pigs increased significantly. We conclude that postsurgical immunotherapy can enhance the effect of cytotoxic drugs administered subsequently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712026; HANNA JR., MICHAEL G. 1; KEY, MARC E. 1; Affiliations: 1: Cancer Metastasis, Treatment Laboratory, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p367; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - PEARSON, RICHARD D.
AU - MANIAN, ALBERT A.
AU - HARCUS, JANE L.
AU - HALL, DENNIS
AU - HEWLETT, ERIK L.
T1 - Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic Protozoan Leishmania donovani.
JO - Science
JF - Science
Y1 - 1982/07/23/
VL - 217
IS - 4557
M3 - Article
SP - 369
EP - 371
SN - 00368075
AB - Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have beenfound to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sandfly, and the intracellular stage, which is found solely in human macrophages during established infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712027; PEARSON, RICHARD D. 1; MANIAN, ALBERT A. 2; HARCUS, JANE L. 3; HALL, DENNIS 3; HEWLETT, ERIK L. 3; Affiliations: 1: Department of Medicine, Division of Geographic Medicine, University of Virginia School of Medicine, Charlottesville 22908; 2: Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857; 3: Department of Medicine, Division of Geographic Medicine, University of Virginia School of Medicine; Issue Info: 7/23/1982, Vol. 217 Issue 4557, p369; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WYSOR, MICHAEL S.
AU - ZWELLING, LEONARD A.
AU - SANDERS, JAMES E.
AU - GRENAN, MARIE M.
T1 - Cure of Mice Infected with Trypanosoma rhodesiense by cis-Diamminedichloroplatinum (II) and Disulfiram Rescue.
JO - Science
JF - Science
Y1 - 1982/07/30/
VL - 217
IS - 4558
M3 - Article
SP - 454
EP - 456
SN - 00368075
AB - Mice infected with Trypanosoma rhodesiense were treated concurrently with cis-diamminedichloroplatinum (HI) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003781; WYSOR, MICHAEL S. 1; ZWELLING, LEONARD A. 2; SANDERS, JAMES E. 3; GRENAN, MARIE M. 4; Affiliations: 1: Department of Parasitology, Walter Reed Army Institute of Research, Washington, D.C. 20012; 2: Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Pathology, Walter Reed Army Institute of Research; 4: Department of Parasitology, Walter Reed Army Institute of Research; Issue Info: 7/30/1982, Vol. 217 Issue 4558, p454; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CARPER, DEBORAH
AU - SHINOHARA, TOSHIMICHI
AU - PIATIGORSKY, JORAM
AU - KINOSHITA, JIN H.
T1 - Deficiency of Functional Messenger RNA for a Developmentally Regulated, β-Crystallin Polypeptide in a Hereditary Cataract.
JO - Science
JF - Science
Y1 - 1982/07/30/
VL - 217
IS - 4558
M3 - Article
SP - 463
EP - 464
SN - 00368075
AB - The messenger RNA for a β-crystallin polypeptide with a molecular size of 27 kilodaltons, first detected 5 to 10 days after birth in the normal mouse lens and the Nakano mouse cataract, was not detected in the Philly mouse cataract with translation in vitro. The heterozygous Philly lens had intermediate levels of the 27- kilodalton β-crystallin polypeptide and exhibited delayed onset of the cataract. The deficiency of functional 27-kilodalton P-crystallin messenger RNA is the earliest lesion reported yet for the Philly lens and points to a transcriptional or posttranscriptional developmental defect in this hereditary cataract. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003785; CARPER, DEBORAH 1; SHINOHARA, TOSHIMICHI 2; PIATIGORSKY, JORAM 2; KINOSHITA, JIN H. 3; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health; 3: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: 7/30/1982, Vol. 217 Issue 4558, p463; Number of Pages: 2p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Rook, A. H.
AU - Djeu, Julie Y.
AU - Balow, J. E.
T1 - Natural killer cells and interferon responses in patients with systemic lupus erythematosus.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/08//
VL - 49
IS - 2
M3 - Article
SP - 239
EP - 245
PB - Wiley-Blackwell
SN - 00099104
AB - Natural killer (NK) cell activity was studied in 23 patients with systemic lupus erythematosus (SLE), The overall NK activity was lower in patients with SLE than in normal female individuals. Patients with clinically active SLE disease had slightly lower NK activity than the patients with inactive disease. Other clinical parameters as well as treatment status did not correlate with NK activity. Interferon (IFN) enhanced the NK activity of normal individuals and of 11 SLE patients, while it did not enhance in the remaining 12 patients. The patients whose NK activity was enhanced by β/IFN had significantly higher initial activity than those who did not respond to β/IFN. Furthermore, peripheral mononuclear cells (MNC) from IFN responders produced γ-IFN after stimulation with concanavalin A (Con A) in titres comparable to those of normals. In contrast, peripheral MNC from β-IFN non-responders failed to produce significant titres of γ-IFN after stimulation with Con A. These results indicate that certain patients with SLE have low NK activity, which is generally paralleled by an inability to respond to exogenous β-IFN and by blunted production of γ-IFN after stimulation with Con A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - SYSTEMIC lupus erythematosus
KW - INTERFERONS
KW - COLLAGEN diseases
KW - IMMUNOCOMPETENT cells
KW - AUTOIMMUNE diseases
N1 - Accession Number: 16252893; Tsokos, G. C. 1 Rook, A. H. 1 Djeu, Julie Y. 1 Balow, J. E. 1; Affiliation: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health and Division of Virology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, USA.; Source Info: Aug1982, Vol. 49 Issue 2, p239; Subject Term: KILLER cells; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: INTERFERONS; Subject Term: COLLAGEN diseases; Subject Term: IMMUNOCOMPETENT cells; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Hofstetter, M.
AU - Poindexter, R. W.
AU - Ruiz-Tiben, E.
AU - Ottesen, E.A.
T1 - Modulation of the host response in human schistosomiasis II. BLOCKING ANTIBODIES SPECIFICALLY INHIBIT IMMEDIATE HYPERSENSITIVITY RESPONSES TO PARASITE ANTIGENS.
JO - Immunology
JF - Immunology
Y1 - 1982/08//
VL - 46
IS - 4
M3 - Article
SP - 777
EP - 785
PB - Wiley-Blackwell
SN - 00192805
AB - Mechanisms for modulating the host's immune response in human Schistosomiasis mansoni have been described for delayed hypersensitivity responsiveness and antibody production. Since clinical symptoms of immediate hypersensitivity (i.e. allergic reactivity) are rare in schistosomiasis despite the presence of parasite-specific immunoglobulin E, circulating parasite antigen, and normal numbers of basophils and mast cells in infected patients, it seemed likely that there was host modulation of immediate hypersensitivity responsiveness as well. Using an in vitro basophil histamine release assay we have shown that basophils from fifteen patients with S. mansoni infections are sensitized with schistosome-specific immunoglobulin E and will release histamine in an antigen-dose-dependent manner when challenged with a soluble adult worm antigen. This histamine release was suppressed by autologus, but not normal serum. Fractionation of the serum over staphylococcal protein A and antigen affinity columns identified an immunoglobulin G parasite-specific 'blocking antibody', analogous to blocking antibodies elicited during immunotherapy of atopic patients, as being responsible for the modulation of this immediate hypersensitivity responsiveness in vitro. Blocking antibody specificity varied from patient to patient, an observation suggesting that different allergens were being recognized by different individuals. These studies demonstrate that in addition to the immunoregulatory mechanisms previously described in patients with schistosome infections, there is host modulation of immediate hypersensitivity responsiveness that appears to involve specific immunoglobulin G blocking antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - SCHISTOSOMIASIS
KW - HELMINTHIASIS
KW - IMMUNOGLOBULIN E
KW - PARASITE antigens
KW - BASOPHILS
KW - MAST cells
N1 - Accession Number: 13935715; Hofstetter, M. 1 Poindexter, R. W. 1 Ruiz-Tiben, E. 2 Ottesen, E.A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2: San Juan Laboratories, Center for Infectious Diseases, Centers for Disease Control, San Juan, Puerto Rico; Source Info: Aug82, Vol. 46 Issue 4, p777; Subject Term: IMMUNE response; Subject Term: SCHISTOSOMIASIS; Subject Term: HELMINTHIASIS; Subject Term: IMMUNOGLOBULIN E; Subject Term: PARASITE antigens; Subject Term: BASOPHILS; Subject Term: MAST cells; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - EPSTEIN, SUZANNE
AU - NADLER, PAUL
AU - LUNNEY, JOAN
T1 - Multiple Submission.
JO - Science
JF - Science
Y1 - 1982/08/20/
VL - 217
IS - 4561
M3 - Article
SP - 686
EP - 686
SN - 00368075
N1 - Accession Number: 84705862; EPSTEIN, SUZANNE 1; NADLER, PAUL 1; LUNNEY, JOAN 1; Affiliations: 1: Immunology Branch, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/20/1982, Vol. 217 Issue 4561, p686; Number of Pages: 1/4p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Hankin, Janet R.
AU - Locke, Ben Z.
T1 - The Persistence of Depressive Symptomatology among Prepaid Group Practice Enrollees: An Exploratory Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/09//
VL - 72
IS - 9
M3 - Article
SP - 1000
EP - 1007
PB - American Public Health Association
SN - 00900036
AB - This exploratory study examines the persistence of depressive symptomatology as measured by the Center for Epidemiologic. Studies Depression Scale (CES-D) Over a 12-month period, half of a group of 309 prepaid group practice enrollees reporting depressive symptoms at the beginning of the interval also had high scores on the CES-D at the end of the interval. Sociodemographic characteristics did not predict persistence of depression. Persistence of depression was positively associated with initially reporting cognitive and affective types of depressive symptoms, the presence of physical illness, the seeking of psychiatric treatment, and the receipt of psychotropic drug prescriptions. (Am J Public Health 1982: 72: 1000-1007. ) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression
KW - SYMPTOMS
KW - SOCIODEMOGRAPHIC factors
KW - PSYCHIATRY
KW - PSYCHIATRIC drugs
N1 - Accession Number: 4949328; Hankin, Janet R. 1 Locke, Ben Z. 2; Affiliation: 1: Center for Metropolitan Planning and Research, Shriver Hall, Johns Hopkins University, Baltimore, MD 21218 2: National Institute of Mental Health; Source Info: Sep82, Vol. 72 Issue 9, p1000; Subject Term: MENTAL depression; Subject Term: SYMPTOMS; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: PSYCHIATRY; Subject Term: PSYCHIATRIC drugs; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Christian, Carole B.
AU - Balow, J. E.
T1 - Concanavalin-induced suppressor cells: characterization on the basis of corticosteroid and radiation sensitivity.
JO - Immunology
JF - Immunology
Y1 - 1982/09//
VL - 47
IS - 1
M3 - Article
SP - 85
EP - 90
PB - Wiley-Blackwell
SN - 00192805
AB - Experiments were performed to examine whether the concanavalin A (Con A)- induced suppressor cells of several in vitro T- and B-lymphocyte functions constitute a functionally unique cell population. This study included simultaneous studies of three different assays of suppression of T- and B-lymphocyte functions. We found that Con-A-induced suppressor cells which inhibit the allogeneic mixed lymphocyte reaction (MLR) and the pokeweed mitogen-induced, plaque-forming cell (PFC) response are radiation sensitive at doses greater than 1000 rad, but corticosteroid resistant, while those suppressing allogeneic cell-mediated lympholysis (CML) are both radiation and corticosteroid resistant. These studies indicate either that Con-A-induced suppressor cells include heterogeneous populations which are differentially sensitive to corticosteroids and radiation, or that functionally distinct suppressor mechanisms are variably sensitive to these agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUPPRESSOR cells
KW - T cells
KW - IMMUNOSUPPRESSION
KW - IMMUNE response
KW - IMMUNOLOGY
KW - B cells
KW - ADRENOCORTICAL hormones
N1 - Accession Number: 13936376; Tsokos, G. C. 1 Christian, Carole B. 1 Balow, J. E. 1; Affiliation: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases; National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Sep82, Vol. 47 Issue 1, p85; Subject Term: SUPPRESSOR cells; Subject Term: T cells; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: B cells; Subject Term: ADRENOCORTICAL hormones; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DHAR, RAVI
AU - ELLIS, RONALD W.
AU - SHIH, THOMAS Y.
AU - OROSZLAN, STEPHEN
AU - SHAPIRO, BRUCE
AU - MAIZEL, JACOB
AU - LowY, DOUGLAS
AU - SCOLNICK, EDWARD
T1 - Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1982/09/03/
VL - 217
IS - 4563
M3 - Article
SP - 934
EP - 937
SN - 00368075
AB - Harvey murine sarcoma virus is a retrovirus which transforms cells by means of a single virally encoded protein called p21 has. We have determined the nucleotide sequence of 1.0 kilobase in the 5' half of the viral genome which encompasses the has coding sequences and its associated regulatory signals. The nucleotide sequence has identified the amino acid sequence of two additional overlapping polypeptides which share their reading frames and the carboxyl termini with p21 but which contain additional NH2-terminal amino acids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712065; DHAR, RAVI 1; ELLIS, RONALD W. 2; SHIH, THOMAS Y. 2; OROSZLAN, STEPHEN 3; SHAPIRO, BRUCE 4; MAIZEL, JACOB 5; LowY, DOUGLAS 6; SCOLNICK, EDWARD 2; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Tumor Virus Genetics, National Cancer Institute; 3: Biological Carcinogenesis Program, Frederick Cancer Research Facility, Frederick, Maryland 21701; 4: Laboratory of Pathology, Image Processing Section, National Cancer Institute; 5: Laboratory of Molecular Genetics, National Institute of Child Health and Development, Bethesda, Maryland 20205; 6: Laboratory of Dermatology, National Cancer Institute; Issue Info: 9/ 3/1982, Vol. 217 Issue 4563, p934; Number of Pages: 4p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Takahashi, Joseph S.
AU - Zatz, Martin
T1 - Regulation of Circadian Rhythmicity.
JO - Science
JF - Science
Y1 - 1982/09/17/
VL - 217
IS - 4565
M3 - Article
SP - 1104
EP - 1111
SN - 00368075
N1 - Accession Number: 84712081; Takahashi, Joseph S. 1,2; Zatz, Martin 1; Affiliations: 1: Members, Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Phannacology Research Associate, National Institute of General Medical Sciences, Bethesda, Maryland 20205; Issue Info: 9/17/1982, Vol. 217 Issue 4565, p1104; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BENVENISTE, RAOUL E.
AU - TODARO, GEORGE J.
AU - LESLIE, CRYSTAL A.
AU - WALD, GEORGE
AU - GELLHORN, ALFRED
AU - ELIOT JR., THEODORE L.
AU - DERSHOWITZ, ALAN M.
AU - POLLACK, HERMAN
T1 - Gene Transfer Between Eukaryotes.
JO - Science
JF - Science
Y1 - 1982/09/24/
VL - 217
IS - 4566
M3 - Article
SP - 1202
EP - 1204
SN - 00368075
N1 - Accession Number: 88003872; BENVENISTE, RAOUL E. 1; TODARO, GEORGE J. 1; LESLIE, CRYSTAL A. 2; WALD, GEORGE 3,4; GELLHORN, ALFRED 5; ELIOT JR., THEODORE L. 6; DERSHOWITZ, ALAN M. 7; POLLACK, HERMAN 8; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118; 3: Marine Biological Laboratory, Woods Hole, Massachusetts 02543; 4: Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138; 5: Department of Health, Policy, and Management, Graduate School of Public Health, Harvard University, Boston, Massachusetts 02115; 6: Fletcher School of Law and Diplomacy, Tufts University, Medford, Massachusetts 02155; 7: Harvard Law School, Cambridge, Massachusetts 02138; 8: AAAS Committee on Scientific Freedom and Responsibility, 1515 Massachusetts Avenue, NW, Washington, D.C. 20005; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1202; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAHL, W. A.
AU - BASHAN, N.
AU - TIETZE, F.
AU - BERNARDINI, I.
AU - SCHULMAN, J. D.
T1 - Cystine Transport Is Defective in Isolated Leukocyte Lysosomes from Patients with Cystinosis.
JO - Science
JF - Science
Y1 - 1982/09/24/
VL - 217
IS - 4566
M3 - Article
SP - 1263
EP - 1265
SN - 00368075
AB - The activity of a cystine transport system in lysosomes prepared from the leukocytes of patients with cystinosis was found to be deficient. In normal subjects, this system was resistant to N-ethylmaleimide and demonstrated saturation kinetics. Lysosomes from individuals heterozygous for cystinosis demonstrated a reduced maximum velocity for cystine egress from lysosomes. The rate of cystine escape from normal lysosomes was enhanced by adenosine triphosphate. The availability of normal and mutant lysosomes provides a means of investigating mechanisms of amino acid transport across lysosomal membranes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003908; GAHL, W. A. 1; BASHAN, N. 1; TIETZE, F. 2; BERNARDINI, I. 1; SCHULMAN, J. D. 1; Affiliations: 1: Section on Human Biochemical and Developmental Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Section on Intermediary Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1263; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZELENKA, PEGGY S.
AU - BEEBE, DAVID C.
AU - FEAGANS, DOUGLAS E.
T1 - Transmethylation of Phosphatidylethanolamine: An Initial Event in Embryonic Chicken Lens Fiber Cell Differentiation.
JO - Science
JF - Science
Y1 - 1982/09/24/
VL - 217
IS - 4566
M3 - Article
SP - 1265
EP - 1267
SN - 00368075
AB - Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiberformation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88003909; ZELENKA, PEGGY S. 1; BEEBE, DAVID C. 2; FEAGANS, DOUGLAS E. 2; Affiliations: 1: Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; Issue Info: 9/24/1982, Vol. 217 Issue 4566, p1265; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Earp, Jo Anne L.
AU - Ory, Marcia G.
AU - Strogatz, Davrd S.
T1 - The Effects of Family Involvement and Practitioner Home Visits on the Control of Hypertension.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/10//
VL - 72
IS - 10
M3 - Article
SP - 1146
PB - American Public Health Association
SN - 00900036
AB - The effectiveness of two social support strategies designed to lower hypertensive patients' blood pressure were compared to each other and to a control group (N = 63) receiving routine care in a randomized clinical trial extending over a period of two years. Group 1 (N = 99) received visits and had family members actively participate in their care through home blood pressure monitoring; Group 2 (N = 56) received home visits from nurses and pharmacists. All groups were predominantly Black. After the first year of the trial, the proportion of patients with uncontrolled diastolic blood pressure (≥95mm Hg) had declined significantly for all three groups; no group showed a statistically significant advantage. However, during the last six months of the second year (after visiting had ended), both Groups 1 and 2 demonstrated clear superiority in DBP control over Group 3, achieving borderline statistical significance (p = .07) when multivariable analysis was performed to control for potential confounders. Supplementing routine care with periodic home visits produced an additional 21 per cent of patients with well-controlled DSP, while involving family members plus visits produced a 17 per cent improvement in the percentage of patients with DSP < 95mm Hg. However, neither support strategy was clearly more effective than the other over time. The efficacy of the interventions is discussed with respect to cost and feasibility of implementation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTENSION
KW - SOCIAL support
KW - SOCIAL services
KW - BLOOD pressure measurement
KW - FRIENDLY visiting
KW - MEDICAL social work
KW - BLOOD circulation disorders
KW - CARDIOVASCULAR diseases
KW - MEDICAL care
KW - PUBLIC health -- United States
N1 - Accession Number: 4952315; Earp, Jo Anne L. 1 Ory, Marcia G. 2 Strogatz, Davrd S. 3; Affiliation: 1: Department of Health Education, School of Public Health, University of North Carolina, Chapel Hill, NC 27514. 2: Social and Behavioral Research, National Institute of Aging, NIH 3: Department of Epidemiology. UNCSPH.; Source Info: Oct82, Vol. 72 Issue 10, p1146; Subject Term: HYPERTENSION; Subject Term: SOCIAL support; Subject Term: SOCIAL services; Subject Term: BLOOD pressure measurement; Subject Term: FRIENDLY visiting; Subject Term: MEDICAL social work; Subject Term: BLOOD circulation disorders; Subject Term: CARDIOVASCULAR diseases; Subject Term: MEDICAL care; Subject Term: PUBLIC health -- United States; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagel, J. E.
AU - Chrest, F. J.
AU - Adler, W. H.
T1 - Mitogenic activity of 12-0-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/10//
VL - 50
IS - 1
M3 - Article
SP - 217
EP - 224
PB - Wiley-Blackwell
SN - 00099104
AB - The effect of age on the proliferative response to 12-O-tetradecanoyl phorbol-13-acetate (TPA) was examined using peripheral blood lymphocytes from 185 adults. TPA-induced DNA synthesis measured by cellular 3H-thymidine incorporation was found, like the responses of cells activated by PHA and Con A, to markedly diminish with advancing age. The presence of indomethacin (1 μ/ml) or Ro 20-5720(10 μg/ml) in TPA activated cell cultures, unlike PHA stimulated cultures, did not result in augmentation of ³H-thymidine incorporation by cells from elderly individuals. These results demonstrate that prostaglandin synthesizing suppressor cells are not responsible for the age-related depression of cellular immune function observed in TPA activated cells and confirm the observation that decreased production and/or utilization of soluble mediators, such as IL-2, may account for the diminished mitogen responsiveness of lymphocytes from elderly individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - MITOGENS
KW - THYMIDINE
KW - CELL culture
KW - DNA
KW - LEUCOCYTES
N1 - Accession Number: 16062931; Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA; Source Info: Oct1982, Vol. 50 Issue 1, p217; Subject Term: LYMPHOCYTES; Subject Term: MITOGENS; Subject Term: THYMIDINE; Subject Term: CELL culture; Subject Term: DNA; Subject Term: LEUCOCYTES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JORDAN, ELKE
AU - CARRICO, CHRISTINE
AU - BEYER, WILLIAM A.
T1 - DNA Database.
JO - Science
JF - Science
Y1 - 1982/10/08/
VL - 218
IS - 4568
M3 - Article
SP - 108
EP - 108
SN - 00368075
N1 - Accession Number: 84705993; JORDAN, ELKE 1; CARRICO, CHRISTINE 1; BEYER, WILLIAM A. 2; Affiliations: 1: National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland 20205; 2: Theoretical Division, Group T-7, Los Alamos National Laboratory, Los Alamos, New Mexico 87545; Issue Info: 10/ 8/1982, Vol. 218 Issue 4568, p108; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WARREN, DWIGHT W.
AU - DUFAU, MARIA L.
AU - CATT, KEVIN J.
T1 - Hormonal Regulation of Gonadotropin Receptors and Steroidogenesis in Cultured Fetal Rat Testes.
JO - Science
JF - Science
Y1 - 1982/10/22/
VL - 218
IS - 4570
M3 - Article
SP - 375
EP - 377
SN - 00368075
AB - Gonadotropic activation of the adult rat testis in vitro and in vivo is followed by down-regulation of luteinizing hormone receptors and decreased androgen responses to subsequent hormonal stimulation. In contrast, treatment of cultured fetal testes with gonadotropins and dibutyryl adenosine 3',5'-monophosphate enhanced steroidogenic responsiveness and did not cause the luteinizing hormone-receptor loss and desensitization that is characteristic of the adult gonad. The analysis of gonadotropin receptors and action in cultured fetal testis cells facilitates developmental studies of gonadal function, and has revealed significant differences in the responses of fetal and adult Leydig cells to gonadotropic regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712145; WARREN, DWIGHT W. 1,2; DUFAU, MARIA L. 1; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Physiology, Biophysics, University of Southern California School of Medicine, Los Angeles 90033; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p375; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WISE, STEVEN P.
AU - HERKENHAM, MILES
T1 - Opiate Receptor Distribution in the Cerebral Cortex of the Rhesus Monkey.
JO - Science
JF - Science
Y1 - 1982/10/22/
VL - 218
IS - 4570
M3 - Article
SP - 387
EP - 389
SN - 00368075
AB - The distribution of opiate receptors in the cerebral cortex of the rhesus monkey (Macaca mulatta) was determined by autoradiographic visualization of [3H]naloxone binding to tissue sections. Naloxone was bound in relatively large amounts to the cortical laminae containing the cell bodies of output neurons, to a varying set of additional laminae in different cortical fields, to fields closer to more primitive types of cortex, and to polysensory corticalfields. From these laminar and areal variations in distribution, it appears that opiate receptors play a role in specific aspects of cortical function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712150; WISE, STEVEN P. 1; HERKENHAM, MILES; Affiliations: 1: Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p387; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - MACKO, KATHLEEN A.
AU - JARVIS, CHARLENE D.
AU - KENNEDY, CHARLES
AU - MIYAOKA, MIKOTO
AU - SHINOHARA, MAMI
AU - SOKOLOFF, Louis
AU - MISHKIN, MORTIMER
T1 - Mapping the Primate Visual System with [2-14C]Deoxyglucose.
JO - Science
JF - Science
Y1 - 1982/10/22/
VL - 218
IS - 4570
M3 - Article
SP - 394
EP - 397
SN - 00368075
AB - The [2-14C]deoxyglucose method was used to identify the cerebral areas related to vision in the rhesus monkey (Macaca mulatta). This was achieved by comparing glucose utilization in a visually stimulated with that in a visually deafferented hemisphere. The cortical areas related to vision included the entire expanse of striate, prestriate, and inferior temporal cortex as far forward as the temporal pole, the posterior part of the inferior parietal lobule, and the prearcuate and inferior prefrontal cortex. Subcortically, in addition to the dorsal lateral geniculate nucleus and superficial layers of the superior colliculus, the structures related to vision included large parts of the pulvinar, caudate, putamen, claustrum, and amygdala. These results, which are consonant with a model of visual function that postulates an occipito-temporo-prefrontal pathway for object vision and an occipito-parieto-prefrontal pathway for spatial vision, reveal the full extent of those pathways and identify their points of contact with limbic, striatal, and diencephalic structures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712153; MACKO, KATHLEEN A. 1; JARVIS, CHARLENE D. 1; KENNEDY, CHARLES 2; MIYAOKA, MIKOTO 2; SHINOHARA, MAMI 2; SOKOLOFF, Louis 2; MISHKIN, MORTIMER 3; Affiliations: 1: Laboratory of Neuropsychology, National Institute of Menial Health, Bethesda, Maryland 20205; 2: Laboratory of Cerebral Metabolism, National Institute of Mental Health; 3: Laboratory of Neuropsychology, National Institute of Mental Health; Issue Info: 10/22/1982, Vol. 218 Issue 4570, p394; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PAUL, STEVEN M.
AU - HULIHAN-GIBLIN, BRIDGET
AU - SKOLNICK, PHIL
T1 - (+)-Amphetamine Binding to Rat Hypothalamus: Relation to Anorexic Potency of Phenylethylamines.
JO - Science
JF - Science
Y1 - 1982/10/29/
VL - 218
IS - 4571
M3 - Article
SP - 487
EP - 490
SN - 00368075
AB - Saturable and stereospecific binding sites for (+)-[HJamphetamine were demonstrated in membrane preparations from rat brain. The density of these binding sites varies among brain regions and is highest in the hypothalamus and brainstem. Specific (+)-[3H]amphetamine binding in hypothalamus is largely confined to synaptosomal membranes, rapidly reversible, and sensitive to both heat and proteolytic enzymes. Scatchard analysis of the equilibrium binding data revealed two distinct sites with apparent affinity constants of 93 and 300 nanomoles per liter, respectively. The effects of various psychotropic drugs as well as a number of putative neurotransmitters and related agonists and antagonists in displacing specific (+)-pHJamphetamine binding demonstrate that these binding sites are not associated with any previously described neurotransmitter or drug receptors, but are specific for amphetamine and related phenylethylamine derivatives. Furthermore, the relative affinities of a series of phenylethylamine derivates for (+)-[HJamphetamine binding sites in hypothalamic membranes is highly correlated to their potencies as anorexic agents. These results suggest the presence of specific receptor sites in hypothalamus that mediate the anorexic activity of amphetamine and related drugs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712190; PAUL, STEVEN M. 1; HULIHAN-GIBLIN, BRIDGET 1; SKOLNICK, PHIL 2; Affiliations: 1: Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 10/29/1982, Vol. 218 Issue 4571, p487; Number of Pages: 4p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Kumar, Nirbhay
AU - Flavin, Martin
T1 - Modulation of Some Parameters of Assembly of Microtubules in vitro by Tyrosinolation of Tubulin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1982/11//11/1/82
VL - 128
IS - 1
M3 - Article
SP - 215
EP - 222
PB - Wiley-Blackwell
SN - 00142956
AB - Using tyrosinolated and detyrosinolaled tubulins, we have compared several parameters of microtubule assembly in vitro. Rates and extents of polymerization were the same under all conditions, but microtubules assembled from detyrosinolated tubulin in the presence of crude microtubule-associated proteins (MAPs) or subsaturating MAP-2 contained a smaller proportion of the MAPs. Preliminary results indicate that this may be a function of the phosphorylation state of MAP-2. Tyrosinolated tubulin assembled into relatively shorter microtubules in the presence of saturating MAP-2. When assembly was induced with substoichiometric concentrations of taxol, in place of MAPs, the rate and extent of assembly were about twice as great with tyrosinolated tubulin. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROTUBULES
KW - TUBULINS
KW - CELL organelles
KW - CHEMICAL reactions
KW - POLYMERS
KW - PHOSPHORYLATION
KW - BIOMOLECULES
N1 - Accession Number: 15808936; Kumar, Nirbhay 1 Flavin, Martin 1; Affiliation: 1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 11/1/82, Vol. 128 Issue 1, p215; Subject Term: MICROTUBULES; Subject Term: TUBULINS; Subject Term: CELL organelles; Subject Term: CHEMICAL reactions; Subject Term: POLYMERS; Subject Term: PHOSPHORYLATION; Subject Term: BIOMOLECULES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Engel, Bernard T.
AU - Joseph, James A.
T1 - Attenuation of Baroreflexes During Operant Cardiac Conditioning.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1982/11//
VL - 19
IS - 6
M3 - Article
SP - 609
EP - 614
SN - 00485772
AB - Three monkeys were trained to slow and to speed heart rate on an operant schedule. After the animals were performing highly reliably they received injections of nitroglycerin or phenylephrine to elicit baro reflexes during control periods and during slowing or speeding sessions. The finding were that each animal reliably attenuated its baroreflex sensitivity and thereby avoided shock. Thus, the data showed that under appropriate behavioral conditions homeostatic adjustments of the cardiovascular system are reduced. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONKEYS
KW - HEART beat
KW - OPERANT conditioning
KW - NITROGLYCERIN
KW - BAROREFLEXES
KW - REFLEXES
KW - Baroreceptors
KW - Baroreflex sensitivity
KW - Biofeedback
KW - Blood pressure
KW - Cardiovascular
KW - Heart rate
KW - Nitroglycerin.
KW - Operant conditioning
KW - Phenylephrine
N1 - Accession Number: 14201467; Engel, Bernard T. 1,2 Joseph, James A. 1; Affiliation: 1: Gerontology Research Center (Baltimore). National Institute on Aging, National Institutes of Health, PHS, U.S. Department of Health and Human Services, Bethesda. 2: Baltimore City Hospital, Baltimore.; Source Info: Nov1982, Vol. 19 Issue 6, p609; Subject Term: MONKEYS; Subject Term: HEART beat; Subject Term: OPERANT conditioning; Subject Term: NITROGLYCERIN; Subject Term: BAROREFLEXES; Subject Term: REFLEXES; Author-Supplied Keyword: Baroreceptors; Author-Supplied Keyword: Baroreflex sensitivity; Author-Supplied Keyword: Biofeedback; Author-Supplied Keyword: Blood pressure; Author-Supplied Keyword: Cardiovascular; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Nitroglycerin.; Author-Supplied Keyword: Operant conditioning; Author-Supplied Keyword: Phenylephrine; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1469-8986.ep14201467
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06544-028
AN - 2006-06544-028
AU - Joseph, J. A.
T1 - Morpho-Physiological and Behavioral Relationships in Senescence.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1982/11//
VL - 27
IS - 11
SP - 885
EP - 885
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06544-028. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Joseph, J. A.; Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Aging; Central Nervous System; Geriatrics; Neural Receptors; Neurotransmitters. Minor Descriptor: Brain; Physiology. Classification: Neuropsychology & Neurology (2520); Gerontology (2860). Population: Human (10). Reviewed Item: Enna, S. J. (Ed); Samorajski, T. (Ed); Beer, Bernard (Ed). Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders=New York: Raven Press, 1981. 290 pp. $32.00; 1981. Page Count: 1. Issue Publication Date: Nov, 1982.
AB - Reviews the book, Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders by S. J. Enna, T. Samorajski, and Bernard Beer (Eds.) (1981). This volume describes in a fairly balanced fashion several aspects of changes occurring in the central nervous system (CNS) during aging. The book can serve as a good source of information to scientists in several disciplines. Several important topics are covered interspecies and methodological correlations in aging, CNS alterations and motor behavior, plasticity, and memory. Unfortunately, no attempt is made to speculate on the consequences of this decline in neuronal population for the aged human. Pertinent topics are well represented in this volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - central nervous system
KW - aging
KW - age related disorders
KW - brain neurotransmitters
KW - neural receptors
KW - 1982
KW - Aging
KW - Central Nervous System
KW - Geriatrics
KW - Neural Receptors
KW - Neurotransmitters
KW - Brain
KW - Physiology
KW - 1982
U2 - Enna, S. J. (Ed); Samorajski, T. (Ed); Beer, Bernard (Ed). (1981); Aging, Vol. 17: Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders; New York: Raven Press, 1981. 290 pp. $32.00
DO - 10.1037/020772
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KALYANARAMAN, V. S.
AU - SARNGADHARAN, M. G.
AU - ROBERT-GUROFF, MARJORIE
AU - MIYOSHI, ISAO
AU - BLAYNEY, DOUGLAS
AU - GoLDE, DAVID
AU - GALLO, ROBERT C.
T1 - A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia.
JO - Science
JF - Science
Y1 - 1982/11/05/
VL - 218
IS - 4572
M3 - Article
SP - 571
EP - 573
SN - 00368075
AB - Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with Tcell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and arefound in adults with an acute malignancy ofmature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A Tcell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(cR), HTLV-I(MB), and HTLV-II(MO)1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84706118; KALYANARAMAN, V. S. 1; SARNGADHARAN, M. G. 2; ROBERT-GUROFF, MARJORIE 2; MIYOSHI, ISAO 3; BLAYNEY, DOUGLAS 4; GoLDE, DAVID 5; GALLO, ROBERT C. 6; Affiliations: 1: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland 20895; 2: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Internal Medicine, Kochi Medical School, Nankoku Kochi 781-SI, Japan; 4: Environmental Epidemiology Branch, National Cancer Institute; 5: Department of Medicine, University of California, Los Angeles 90024; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 11/ 5/1982, Vol. 218 Issue 4572, p571; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FAVERA, RICCARDO DALLA
AU - GALLO, ROBERT C.
AU - GIALLONGO, AGATA
AU - CROCE, CARLO M.
T1 - Chromosomal Localization of the Human Homolog (c-sis) of the Simian Sarcoma Virus onc Gene.
JO - Science
JF - Science
Y1 - 1982/11/12/
VL - 218
IS - 4573
M3 - Article
SP - 686
EP - 688
SN - 00368075
AB - Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region qll-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22qll>qter. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712227; FAVERA, RICCARDO DALLA 1; GALLO, ROBERT C. 1; GIALLONGO, AGATA 2; CROCE, CARLO M. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, 36th Street, Spruce, Philadelphia, Pennsylvania 19104; Issue Info: 11/12/1982, Vol. 218 Issue 4573, p686; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MUKHERJEE, ANIL B.
AU - HODGEN, GARY D.
T1 - Maternal Ethanol Exposure Induces Transient Impairment of Umbilical Circulation and Fetal Hypoxia in Monkeys.
JO - Science
JF - Science
Y1 - 1982/11/12/
VL - 218
IS - 4573
M3 - Article
SP - 700
EP - 702
SN - 00368075
AB - When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption offeto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712235; MUKHERJEE, ANIL B. 1; HODGEN, GARY D. 1; Affiliations: 1: Pregnancy Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/12/1982, Vol. 218 Issue 4573, p700; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - WEST, JAMES R.
AU - LIND, MARCIA D.
AU - DEMUTH, RONALD M.
AU - PARKER, ELIZABETH S.
AU - ALKANA, RONALD L.
AU - CASSELL, MARTIN
AU - BLACK JR., ASA C.
T1 - Lesion-Induced Sprouting in the Rat Dentate Gyrus Is Inhibited by Repeated Ethanol Administration.
JO - Science
JF - Science
Y1 - 1982/11/19/
VL - 218
IS - 4574
M3 - Article
SP - 808
EP - 810
SN - 00368075
AB - The effect of ethanol on hippocampal axonal sprouiting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcholinesterase staining in the outer molecular layer and a concomitant increase in the width of the pale-staining commissural-associational zone of the dentate gyrus. Other rats were given ethanol (11.3 ± 0.45 grams per kilogram) for 2 weeks before and 9 days after receiving the lesion. Ethanol abolished the expansion of the commissural-associational zone. The effect of ethanol on sprouting axons suggests that it may inhibit recovery of function after brain injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712271; WEST, JAMES R. 1; LIND, MARCIA D. 1; DEMUTH, RONALD M. 2; PARKER, ELIZABETH S. 3; ALKANA, RONALD L. 4; CASSELL, MARTIN 5; BLACK JR., ASA C. 5; Affiliations: 1: Department of Anatomy, University of Iowa College of Medicine, Iowa City 52242; 2: Department of Psychology, University of Northern Illinois, De Kalb 60115; 3: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20205; 4: Institute of Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033; 5: Department of Anatomy, University of Iowa College of Medicine; Issue Info: 11/19/1982, Vol. 218 Issue 4574, p808; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - AASLESTAD, HALVOR G.
T1 - Peer Review at NIH.
JO - Science
JF - Science
Y1 - 1982/11/26/
VL - 218
IS - 4575
M3 - Article
SP - 840
EP - 840
SN - 00368075
N1 - Accession Number: 84712275; AASLESTAD, HALVOR G. 1; Affiliations: 1: Biological Sciences Review Section, Division of Research Grants, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/26/1982, Vol. 218 Issue 4575, p840; Number of Pages: 5/6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bailey, Kent
T1 - Biometry (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1982/12//
VL - 77
IS - 380
M3 - Book Review
SP - 946
SN - 01621459
AB - Reviews the book "Biometry: The Principles and Practice of Statistics in Biological Research," by Robert R. Sokal and F. James Rohlf.
KW - BIOMETRY
KW - NONFICTION
KW - SOKAL, Robert
KW - SOKAL, Robert R.
KW - ROHLF, F. James
KW - BIOMETRY (Book)
N1 - Accession Number: 4606385; Bailey, Kent 1; Affiliations: 1: National Heart, Lung and Blood Institute.; Issue Info: Dec82, Vol. 77 Issue 380, p946; Subject Term: BIOMETRY; Subject Term: NONFICTION; Reviews & Products: BIOMETRY (Book); People: SOKAL, Robert; People: SOKAL, Robert R.; People: ROHLF, F. James; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - BLAIR, D. G.
AU - COOPER, C. S.
AU - OSKARSSON, M. K.
AU - EADER, L. A.
AU - WOUDE, G. F. VANDE
T1 - New Method for Detecting Cellular Transforming Genes.
JO - Science
JF - Science
Y1 - 1982/12/10/
VL - 218
IS - 4577
M3 - Article
SP - 1122
EP - 1125
SN - 00368075
AB - Tumor induction in athymic nude mice can be used to detect dominant transforming genes in cellular DNA. Mouse NIH 3T3 cells freshly transfected with either cloned Moloney sarcoma proviral DNA or cellular DNA's derivedfrom virally transformed cells induced tumors when injected into athymic nulnu mice. Tumors were also induced by cells transfected with DNA from two tumor-derived and one chemically transformed human cell lines. The mouse tumors induced by human cell line DNA's contained human DNA sequences, and DNA derivedfrom these tumors was capable of inducing both tumors and foci on subsequent transfection. Tumor induction in nude mice represents a useful new method for the detection and selection of cells transformed by cellular oncogenes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712387; BLAIR, D. G. 1; COOPER, C. S. 2; OSKARSSON, M. K. 2; EADER, L. A. 3,4; WOUDE, G. F. VANDE 2; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 20205; 3: National Institutes Health, Intramural Research Support Program; 4: National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1122; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ALLEN, ROBERT DAY
AU - METUZALS, JANIS
AU - TASAKI, ICHUI
AU - BRADY, SCOOT T.
AU - GILBERT, SUSAN P.
T1 - Fast Axonal Transport in Squid Giant Axon.
JO - Science
JF - Science
Y1 - 1982/12/10/
VL - 218
IS - 4577
M3 - Article
SP - 1127
EP - 1129
SN - 00368075
AB - Video-enhanced contrast-differential interference contrast microscopy has revealed new features of axonal transport in the giant axon of the squid, where no movement had been detected previously by conventional microscopy. The newly discovered dominant feature is vast numbers of "submicroscopic" particles, probably 30- to 50-nanometer vesicles and other tubulovesicular elements, moving parallel to linear elements, primarily in the orthograde direction but also in a retrograde direction, at a range of steady velocities up to ±5 micrometers per second. Medium (0.2 to 0.6 micrometer) and large (0.8 micrometer) particles move more slowly and more intermittently with a tendency at times to exhibit elastic recoil. The behavior of the smallest particles and the larger particles during actual translocation suggests that the fundamental processes in the mechanisms of organelle movement in axonal transport are not saltatory but continuous. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712389; ALLEN, ROBERT DAY 1; METUZALS, JANIS 2; TASAKI, ICHUI 3; BRADY, SCOOT T. 4; GILBERT, SUSAN P. 5; Affiliations: 1: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755; 2: Department of Anatomy, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada KIN 9A9; 3: Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20014; 4: Department of Anatomy, Case Western Reserve Medical School, Cleveland, Ohio 44106; 5: Department of Biological Sciences, Dartmouth College; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1127; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROBBINS, KEITH C.
AU - DEVARE, SUSHILKUMAR G.
AU - REDDY, E. PREMKUMAR
AU - AARONSON, STUART A.
T1 - In vivo Identification of the Transforming Gene Product of Simian Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1982/12/10/
VL - 218
IS - 4577
M3 - Article
SP - 1131
EP - 1133
SN - 00368075
AB - Simian sarcoma virus (SSV) deletion mutants were constructed from a molecular clone containing the entire infectious provirus. Transfection analysis of these mutants localized the SSV transforming gene to a small region of the viral genome encompassing its cell-derived sequence (v-sis). Antiserum to a peptide synthesized on the basis of the predicted amino acid sequence of the SSV transforming gene detected a 28,000-dalton protein that was specifically expressed in SSV transformed cells and that corresponded in size to that predicted from the v-sis coding sequence. The v-sis gene product designated p28sis was not a phosphoprotein, nor did it possess detectable protein kinase activity. These findings distinguish p28sis from a number of other retroviral onc proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712391; ROBBINS, KEITH C. 1; DEVARE, SUSHILKUMAR G. 1; REDDY, E. PREMKUMAR 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/10/1982, Vol. 218 Issue 4577, p1131; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LOUMAYE, ERNEST
AU - THORNER, JEREMY
AU - CATT, KEVIN J.
T1 - Yeast Mating Pheromone Activates Mammalian Gonadotrophs: Evolutionary Conservation of a Reproductive Hormone?
JO - Science
JF - Science
Y1 - 1982/12/24/
VL - 218
IS - 4579
M3 - Article
SP - 1323
EP - 1325
SN - 00368075
AB - α-Factor, a tridecapeptide mating pheromone of yeast (Saccharomyces cerevisiae), has extensive sequence homology with the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH). Both synthetic and natural preparations of α-mating factor were found to bind specifically to rat pituitary GnRH receptors and to stimulate the release of luteinizing hormonefrom cultured gonadotrophs. The ability of the yeast pheromone to reproduce the biological actions of GnRH in the mammalian pituitary gland indicates that the structural andfunctional properties of GnRH-related peptides may have been highly conserved during evolution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712468; LOUMAYE, ERNEST 1,2; THORNER, JEREMY 3; CATT, KEVIN J. 1; Affiliations: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20816; 2: Department of Obstetrics and Gynecology, University of Louvain, 5330. 53 av. Em. Mounier, B-1200, Brussels, Belgium; 3: Departtnent of Microbiology and Immunology, University of California, Berkeley 94720; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1323; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MURPHY, BRIAN R.
AU - SLY, D. LEWIS
AU - TIERNEY, EVELINE L.
AU - HOSIER, NANETTE T.
AU - MASSICOT, JUDITH G.
AU - LONDON, WILLIAM T.
AU - CHANOCK, ROBERT M.
AU - WEBSTER, ROBERT G.
AU - HINSHAW, VIRGINIA S.
T1 - Reassortant Virus Derived from Avian and Human Influenza A Viruses Is Attenuated and Immunogenic in Monkeys.
JO - Science
JF - Science
Y1 - 1982/12/24/
VL - 218
IS - 4579
M3 - Article
SP - 1330
EP - 1332
SN - 00368075
AB - An influenza A reassortant virus that contained the hemagglutinin and neuraminidase genes of a virulent human virus, A/Udorn/72 (H3N2), and the six other influenza A virus genome segments from an avirulent avian virus, AlMallardl New York/6750/78 (H2N2), was evaluated for its level of replication in squirrel monkeys and hamsters. In monkeys, the reassortant virus was as attenuated and as restricted in its level of replication in the upper and lower respiratory tract as its avian influenza virus parent. Nonetheless, infection with the reassortant induced significant resistance to challenge with virulent human influenza virus. In hamsters, the reassortant virus replicated to a level intermediate between that of its parents. These findings suggest that the nonsurface antigen genes of the avian parental virus are the primary determinants of restriction of replication of the reassortant virus in monkeys. Attenuation of the reassortant virus for primates is achieved by the inefficient functioning of the avian influenza genes in primate cells, while antigenic specificity of the human influenza virus is provided by the neuraminidase and hemagglutinin genes derivedfrom the human virus. This approach could lead to the development of a live influenza A virus vaccine that is attenuatedfor man if the avian influenza genes are similarly restricted in human cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712471; MURPHY, BRIAN R. 1,2; SLY, D. LEWIS 3; TIERNEY, EVELINE L. 4; HOSIER, NANETTE T. 4; MASSICOT, JUDITH G. 4; LONDON, WILLIAM T. 5,6; CHANOCK, ROBERT M. 4; WEBSTER, ROBERT G. 7; HINSHAW, VIRGINIA S. 7; Affiliations: 1: Laboratory of Infectious Diseases, National Institute of Allergy, Bethesda, Maryland 20205; 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Meloy Laboratories, Rockville, Maryland 20851; 4: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; 5: National Institute of Neurological and Communicative Disorders and Stroke; 6: National Institutes of Health; 7: Division of Virology, St. Jude Children's Hospital, Memphis, Tennessee 28101; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1330; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NINAN, PHILIP T.
AU - INSEL, THOMAS M.
AU - COHEN, ROBERT M.
AU - COOK, JAMES M.
AU - SKOLNICK, PHIL
AU - PAUL, STEVEN M.
T1 - Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates.
JO - Science
JF - Science
Y1 - 1982/12/24/
VL - 218
IS - 4579
M3 - Article
SP - 1332
EP - 1334
SN - 00368075
AB - The ethyl ester of β-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonists, antagonists, or "active" antagonists such as β-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of β-carboline-3-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712472; NINAN, PHILIP T. 1; INSEL, THOMAS M. 2; COHEN, ROBERT M. 2; COOK, JAMES M. 3; SKOLNICK, PHIL 4; PAUL, STEVEN M. 5; Affiliations: 1: Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Clinical Neuropharmacology Branch, National Institute of Mental Health; 3: Department of Chemistry, University of Wisconsin, Milwaukee 53201; 4: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; 5: Clinical Neuroscience Branch, National Institute of Mental Health; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1332; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSTEIN, JOHN N.
AU - PARKER, ROBERT J.
AU - KEENAN, ANDREW M.
AU - DOWER, STEVEN K.
AU - MORSE III, HERBERT C.
AU - SIEBER, SUSAN M.
T1 - Monoclonal Antibodies in the Lymphatics: Toward the Diagnosis and Therapy of Tumor Metastases.
JO - Science
JF - Science
Y1 - 1982/12/24/
VL - 218
IS - 4579
M3 - Article
SP - 1334
EP - 1337
SN - 00368075
AB - Monoclonal antibodies subcutaneously injected into mice track to regional lymph nodes and specifically label target cells there. The lymphatic route of administration can be expected to provide much higher sensitivity, higher target-tobackground ratio, faster localization, and lower toxicity than the intravenous route when the aim is to diagnose or treat tumor metastases or lymphoma in the lymph nodes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712473; WEINSTEIN, JOHN N. 1; PARKER, ROBERT J. 2; KEENAN, ANDREW M. 3; DOWER, STEVEN K. 4; MORSE III, HERBERT C. 5; SIEBER, SUSAN M. 2; Affiliations: 1: Laboratory of Mathematical Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Laboratory of Chemical Pharmacology, National Cancer Institute; 3: Department of Nuclear Medicine, National Institutes of Health, Bethesda, Maryland 20205; 4: Immunology Branch, National Cancer Institute; 5: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1334; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ZOLA-MORGAN, STUART
AU - SQUIRE, LARRY R.
AU - MISHKIN, MORTIMER
T1 - The Neuroanatomy of Amnesia: Amygdala-Hippocampus versus Temporal Stem.
JO - Science
JF - Science
Y1 - 1982/12/24/
VL - 218
IS - 4579
M3 - Article
SP - 1337
EP - 1339
SN - 00368075
AB - Using a task known to be sensitive to human amnesia, we have evaluated two current hypotheses about which brain regions must be damaged to produce the disorder. Monkeys with bilateral transections of the white matter of the temporal stem were unimpaired, but monkeys with conjoint amygdala-hippocampal lesions exhibited a severe memory deficit. The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712474; ZOLA-MORGAN, STUART 1,2; SQUIRE, LARRY R. 1,2; MISHKIN, MORTIMER 3; Affiliations: 1: Veterans Administration Medical Center, San Diego, California 92161; 2: Department of Psychiatry, University of California, San Diego; 3: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20014; Issue Info: 12/24/1982, Vol. 218 Issue 4579, p1337; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hiller, Rita
AU - Krueger, Dean E.
T1 - Validity of a Survey Question as a Measure of Visual Acuity Impairment.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/01//
VL - 73
IS - 1
M3 - Article
SP - 93
EP - 96
PB - American Public Health Association
SN - 00900036
AB - Survey questions are frequently used to collect data on the prevalence of vision difficulties. The 1971-1972 Health and Nutrition Examination Survey included both a question about ‘trouble with your vision even when wearing glasses or contact lenses,’ and clinical measurement of central distance visual acuity with usual corrective lenses. The question had low sensitivity for impairment of visual acuity, with variation by age and severity of impairment. Sensitivity analyses from other studies are reviewed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - VISUAL acuity
KW - VISION disorders
KW - HEALTH & Nutrition Examination Survey
KW - OPHTHALMIC lenses
KW - CONTACT lenses
KW - EYE -- Examination
KW - EYE -- Care & hygiene
KW - EYE -- Diseases
N1 - Accession Number: 4949175; Hiller, Rita 1 Krueger, Dean E. 2; Affiliation: 1: MS, Office of Biometry and Epidemiology, National Eye Institute, Bldg. 31, Rm. 6A24, Bethesda, MD 20205 2: Biostatistics Center, George Washington University; Source Info: Jan1983, Vol. 73 Issue 1, p93; Subject Term: HEALTH surveys; Subject Term: VISUAL acuity; Subject Term: VISION disorders; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: OPHTHALMIC lenses; Subject Term: CONTACT lenses; Subject Term: EYE -- Examination; Subject Term: EYE -- Care & hygiene; Subject Term: EYE -- Diseases; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423460 Ophthalmic Goods Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobs, Barry E.
AU - Walczak, Cynthia A.
T1 - A Generalized Query-by-Example Data Manipulation Language Based on Database Logic.
JO - IEEE Transactions on Software Engineering
JF - IEEE Transactions on Software Engineering
Y1 - 1983/01//
VL - 9
IS - 1
M3 - Article
SP - 40
EP - 57
SN - 00985589
AB - The purpose of this paper is to introduce a Generalized-Query-By-Example (GQBE) data manipulation language (DML) that can be built on top of most existing databases (i.e., relational, hierarchical, and network). The data manipulation language supports retrieval, insertion, deletion, and update operations and has a formal semantics based on database logic. It is also seen that GQBE can by used as a DML on external views of an integrated database. We also show the advantages of GQBE on heterogeneous databases over Zloof's QBE on relational external views. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Software Engineering is the property of IEEE Computer Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - COMPUTER logic
KW - INFORMATION storage & retrieval systems
KW - SOFTWARE engineering
KW - COMPUTER software
KW - COMPUTER systems
KW - Database
KW - database logic
KW - generalized Query-By- Example.
N1 - Accession Number: 14403920; Jacobs, Barry E. 1 Walczak, Cynthia A. 2; Affiliation: 1: Department of Computer Science, University of Maryland, College Park, MD 20742 2: Microbial Systematics Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20205; Source Info: Jan83, Vol. 9 Issue 1, p40; Subject Term: DATABASES; Subject Term: COMPUTER logic; Subject Term: INFORMATION storage & retrieval systems; Subject Term: SOFTWARE engineering; Subject Term: COMPUTER software; Subject Term: COMPUTER systems; Author-Supplied Keyword: Database; Author-Supplied Keyword: database logic; Author-Supplied Keyword: generalized Query-By- Example.; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 18p; Illustrations: 8 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Giambra, Leonard M.
T1 - DAYDREAMING IN 40- TO 60-YEAR-OLD WOMEN: MENOPAUSE, HEALTH, VALUES, AND SEXUALITY.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1983/01//
VL - 39
IS - 1
M3 - Article
SP - 11
EP - 21
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article focuses on a study related to daydreaming in 40 to 60 year old women. Two midlife influences are found to have its impact in daydreaming. This study reveals that daydreaming tend to be more prevalent among women who exhibit various psychological symptoms. These symptoms include poor physical health and abnormal variability of menopause. The period from 40 to 60 years of age, in women, bears a most important biological event, which is the period of transition to menopause. A clear change in hormonal balance is accompanied during this transition phase as well as the cessation of menses. Often the transition period is accompanied by psychological, sociological, social, familial, and economic changes that may be causally unrelated to the menopause itself. According to the study, menopause occurs with the cessation of menses. The main impact of menopause on Fear of Failure Daydreams reveals that the means increase as groups shift from pre-menopausal to menopausal to post-menopausal.
KW - DREAMS
KW - SLEEP disorders
KW - MENOPAUSE
KW - MENSTRUATION
KW - CLINICAL psychology
KW - CLIMACTERIC
N1 - Accession Number: 19103203; Giambra, Leonard M. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals.; Source Info: Jan1983, Vol. 39 Issue 1, p11; Subject Term: DREAMS; Subject Term: SLEEP disorders; Subject Term: MENOPAUSE; Subject Term: MENSTRUATION; Subject Term: CLINICAL psychology; Subject Term: CLIMACTERIC; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hardy, Margaret H.
AU - van Exan, R. J.
AU - Sonstegard, Karen S.
AU - Sweeny, P. R.
T1 - Basal Lamina Changes During Tissue Interactions in Hair Follicles--An In Vitro Study of Normal Dermal Papillae and Vitamin A-Induced Glandular Morphogenesis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/01//
VL - 80
IS - 1
M3 - Article
SP - 27
EP - 34
SN - 0022202X
AB - Skin pieces from 14-day fetal mice were cultivated for 1-10 days prior to fixation and sectioning. Subsequently, sections were studied by light and transmission electron microscopy. In a standard medium the lateral hair follicle walls showed progressive maturation of the basal lamina, while the hair matrix, at the time of a known tissue interaction, showed the formation of gaps in the basal lamina, With heterotypic cell contacts through the gaps. In a vitamin-A enriched medium similar changes occurred, not only at the hair matrix, but also at lateral follicle walls, at the sites of, and prior to, budding and glandular morphogenesis. This study shows that the induction of hair matrix by dermal papilla may perhaps be added to the list of normal tissue interactions in which heterotypic cell contacts occur. It also suggests that vitamin-A induced glandular morphogenesis might come about through a mechanism resembling a normal tissue interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRON microscopy
KW - MASONRY
KW - MORPHOLOGY
KW - TRANSMISSION electron microscopy
KW - MORPHOGENESIS
KW - MATRICES
N1 - Accession Number: 12530968; Hardy, Margaret H. 1,2 van Exan, R. J. 1,3 Sonstegard, Karen S. 1,4 Sweeny, P. R. 2; Affiliation: 1: Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada. 2: Department of Microbiology, University of Guelph, Guelph, Ontario, Canada. 3: Connaught Medical Research Laboartories, 1755 Steele Avenue West, Willowdale, Ontario. 4: National Institute of Environmental Health Sciences, Triangle Park, North Carolina.; Source Info: Jan1983, Vol. 80 Issue 1, p27; Subject Term: ELECTRON microscopy; Subject Term: MASONRY; Subject Term: MORPHOLOGY; Subject Term: TRANSMISSION electron microscopy; Subject Term: MORPHOGENESIS; Subject Term: MATRICES; NAICS/Industry Codes: 238140 Masonry Contractors; NAICS/Industry Codes: 327310 Cement Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12530968
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-09089-005
AN - 2008-09089-005
AU - Weiss, Stephen M.
T1 - Planning the conference.
T3 - Proceedings of the National Working Conference on Education and Training in Health Psychology
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1983///
VL - 2
IS - 5, Suppl
SP - 19
EP - 25
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
N1 - Accession Number: 2008-09089-005. Partial author list: First Author & Affiliation: Weiss, Stephen M.; National Heart, Lung, and Blood Institute, US. Other Publishers: American Psychological Association. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Psychology; Psychologists; Scientific Communication. Minor Descriptor: American Psychological Association Divisions. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 7. Issue Publication Date: 1983.
AB - Since the founding of Division 38 nearly 6 years ago, the sub-discipline of 'Health Psychology' has sustained dramatic growth. This has been due, in large measure, to the new opportunities in health settings that have become available through recognition of the role of behavioral and environmental factors in chronic disease prevention and control. Behavioral medicine, preventive medicine, behavioral health, and health promotion are all relatively new approaches to health and disease issues that require major input from appropriately trained behavioral scientists. These developments have stimulated a need for training resources at the graduate, postgraduate, and continuing education levels to adequately prepare psychologists to function in health settings related to basic and clinical research as well as applied care. Several academic programs have already been developed in health psychology in an effort to be responsive to this perceived need. Increasing numbers of academic institutions have expressed strong interest in developing such programs. It appeared timely for the Division of Health Psychology to review the accomplishments (and difficulties) experienced to date by the existing training programs, to assess requisite skills and knowledge required to function effectively in the various research, professional, and administrative health settings and to formulate guidelines and recommended standards for graduate, postgraduate, and continuing educational levels of training in health psychology. This article reviews the planning and implementation process that went in to developing the National Working Conference on Education and Training in Health Psychology, held in May, 1983. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - National Working Conference on Education and Training in Health Psychology
KW - conference planning
KW - APA Division of Health Psychology
KW - 1983
KW - Health Care Psychology
KW - Psychologists
KW - Scientific Communication
KW - American Psychological Association Divisions
KW - 1983
DO - 10.1037/h0090287
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06531-022
AN - 2006-06531-022
AU - Coelho, George V.
T1 - Coping Behavior in Disasters.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1983/01//
VL - 28
IS - 1
SP - 36
EP - 37
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06531-022. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Coelho, George V.; Research Development Review Branch, Office of Extramural Project Review, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Coping Behavior; Disasters; Mental Health; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Cohen, Raquel E.; Ahearn, Frederick L. Jr. Handbook for Mental Health Care of Disaster Victims=Baltimore, Md.: Johns Hopkins University Press, 1980. 143 pp. $12.95 cloth; 1980. Page Count: 2. Issue Publication Date: Jan, 1983.
AB - Reviews the book, Handbook for Mental Health Care of Disaster Victims by Raquel E. Cohen and Frederick L. Ahearn, Jr. (1980). This slim handbook consists of nine chapters organized around two main foci: (a) mental health factors relevant to disaster events and (b) mental health practices applicable to victims of disaster. The volume's broad scope is impressive. Yet while espousing, implicitly, ethnographic methods, it seems to entertain monocultural assumptions. This handbook, unlike the typical handbook in psychology, is handy; primarily designed for the practitioner, it is portable and usable as a field operations manual. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - disaster victims
KW - coping behavior
KW - 1983
KW - Coping Behavior
KW - Disasters
KW - Mental Health
KW - Mental Health Services
KW - 1983
U2 - Cohen, Raquel E.; Ahearn, Frederick L. Jr. (1980); Handbook for Mental Health Care of Disaster Victims; Baltimore, Md.: Johns Hopkins University Press, 1980. 143 pp. $12.95 cloth
DO - 10.1037/021541
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09089-010
AN - 2008-09089-010
AU - MacCanon, Donald
T1 - Research training interests of the Division of Heart and Vascular Diseases of the National Heart, Lung, and Blood Institute.
T3 - Proceedings of the National Working Conference on Education and Training in Health Psychology
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1983///
VL - 2
IS - 5, Suppl
SP - 63
EP - 65
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
N1 - Accession Number: 2008-09089-010. Partial author list: First Author & Affiliation: MacCanon, Donald; National Heart, Lung, and Blood Institute, US. Other Publishers: American Psychological Association. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Change; Cardiovascular Disorders; Health Education; Interdisciplinary Research; Prevention. Minor Descriptor: Government Agencies; Health Care Psychology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 3. Issue Publication Date: 1983.
AB - Discusses the importance of interdisciplinary collaboration and communication. Communication and understanding of cardiovascular problems by other disciplinary members is a huge challenge. During the last 20 years the mortality rate from coronary heart disease has decreased by 30%. Changes in human behavior such as cessation of smoking, improved dietary and exercise habits seem to account for a large portion of the improvement. Despite these advances, cardiovascular disease continues to be the number one cause of death in the United States. New fundamental and clinical discoveries in addition to behavioral changes may make it possible to prevent the development of cardiovascular disease. This belief is reflected in the Congressional Mandate of the National Heart, Lung, and Blood Institute to encourage programs to promote Prevention, Education, and Control of Diseases in these areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - interdisciplinary collaboration
KW - cardiovascular disease
KW - human behavior
KW - behavioral changes
KW - prevention
KW - education
KW - National Heart
KW - Lung
KW - and Blood Institute
KW - congressional mandate
KW - 1983
KW - Behavior Change
KW - Cardiovascular Disorders
KW - Health Education
KW - Interdisciplinary Research
KW - Prevention
KW - Government Agencies
KW - Health Care Psychology
KW - 1983
DO - 10.1037/h0090292
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09089-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09727-002
AN - 2005-09727-002
AU - Schooler, Nina R.
AU - Carpenter, William T. Jr.
T1 - New Drug Treatment Strategies in Schizophrenia: Editorial Introduction.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1983///
VL - 9
IS - 4
SP - 500
EP - 503
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Schooler, Nina R., Pharmacologic and Somatic Treatments Branch, Division of Extramural Research Programs, NIMH, Parklawn Bldg., Room 10-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09727-002. PMID: 6140749 Partial author list: First Author & Affiliation: Schooler, Nina R.; Pharmacologic and Somatic Treatments Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Neuroleptic Drugs; Psychosocial Rehabilitation; Schizophrenia; Symptoms. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 4. Issue Publication Date: 1983.
AB - The recognition of both the value and limitations of antipsychotic drug treatment has led to research on effective alternative strategies for treatment. The authors review assumptions underlying such strategies and introduce five articles pertinent to the topic. These articles address: the use of drugs other than antipsychotic neuroleptics; the use of reduced dosages of antipsychotic drugs; the initiation of antipsychotic drugs early during periods of symptom exacerbation to prevent full relapse; the use of psychosocial treatment strategies in relation to drug treatment; and the development of antipsychotic drugs following models based on restitutive systems in the brain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antipsychotic drugs
KW - drug treatment strategies
KW - reduced dosage strategy
KW - psychosocial treatment strategies
KW - antipsychotic neuroleptics
KW - symptom exacerbation
KW - schizophrenia
KW - 1983
KW - Drug Dosages
KW - Neuroleptic Drugs
KW - Psychosocial Rehabilitation
KW - Schizophrenia
KW - Symptoms
KW - 1983
DO - 10.1093/schbul/9.4.500
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Arnow, Kathryn Smul
T1 - The University's Entry Fee to Federal Research Programs.
JO - Science
JF - Science
Y1 - 1983/01/07/
VL - 219
IS - 4580
M3 - Article
SP - 27
EP - 32
SN - 00368075
N1 - Accession Number: 84712484; Arnow, Kathryn Smul 1; Affiliations: 1: Director, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p27; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOPIN, IRWIN J.
AU - GORDON, E. K.
AU - JIMERSON, D. C.
AU - POLINSKY, R. J.
T1 - Relation Between Plasma and Cerebrospinal Fluid Levels of 3-Methoxy-4-Hydroxyphenylglycol.
JO - Science
JF - Science
Y1 - 1983/01/07/
VL - 219
IS - 4580
M3 - Article
SP - 73
EP - 75
SN - 00368075
AB - Concentrations of free 3-methoxy4-hydroxyphenylglycol in the plasma and cerebrospinalfluid are highly correlated, but concentrations in the cerebrospinal fluid are always higher than those in plasma, even when large amounts of the catecholamine metabolite are derived from a tumor of the adrenal medulla. This is explained by considering the plasma and cerebrospinalfluid as a two-compartment system in which the rate constants for entry into and exitfrom the cerebrospinalfluid compartment are similar. 3-Methoxy4-hydroxyphenylglycol that is synthesized, but not catabolized, in the central nervous system maintains cerebrospinalfluid levels at an increment over those in plasma. This increment can be used to provide the best available index of formation of 3-methoxy4-hydroxyphenylglycol in the central nervous system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712512; KOPIN, IRWIN J. 1; GORDON, E. K. 1; JIMERSON, D. C. 1; POLINSKY, R. J. 1; Affiliations: 1: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p73; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAZARUS, L. H.
AU - DIAUGUSTINE, R. P.
AU - JAHNKE, G. D.
AU - HERNANDEZ, O.
T1 - Physalaemin: An Amphibian Tachykinin in Human Lung Small-Cell Carcinoma.
JO - Science
JF - Science
Y1 - 1983/01/07/
VL - 219
IS - 4580
M3 - Article
SP - 79
EP - 81
SN - 00368075
AB - Immunoreactivity to the amphibian peptide physalaemin was characterized from extracts of a human lung small-cell carcinoma by immunological, chemical, and pharmacological means. Tumor-related peptide cross-reacted with three antiserums to physalaemin to yield 1.1 to 1.6 nanomoles per gram of tissue. Physalaemin and tumor peptide had similar retention times on high-performance liquid chromatography after chemical and enzymic modifications that included pH changes, oxone oxidation, use of a hydrophilic ion-pairing reagent, and digestion with trypsin and pyroglutamate aminopeptidase. Both physalaemin and the tumor peptide produced a contractile response of isolated guinea pig ileum at threshold concentrations of approximately 100 to 150 picograms per milliliter. These data suggest that small-cell carcinoma of the lung contains a physalaemin-like peptide that has structural and biological homology to its amphibian counterpart. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712515; LAZARUS, L. H. 1; DIAUGUSTINE, R. P. 2; JAHNKE, G. D. 3; HERNANDEZ, O. 4; Affiliations: 1: Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2770; 2: Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences; 3: School of Veterinary Medicine, North Carolina State University, Raleigh 27650; 4: Laboratory of Environmental Chemistry, National Institute of Environmental Health Sciences; Issue Info: 1/ 7/1983, Vol. 219 Issue 4580, p79; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ALKON, DANIEL L.
AU - ACOSTA-URQUIDI, JUAN
AU - OLDS, JAMES
AU - KUZMA, GREGORY
AU - NEARY, JOSEPH T.
T1 - Protein Kinase Injection Reduces Voltage-Dependent Potassium Currents.
JO - Science
JF - Science
Y1 - 1983/01/21/
VL - 219
IS - 4582
M3 - Article
SP - 303
EP - 306
SN - 00368075
AB - Intracellular iontophoretic injection of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase increased input resistance and decreased a delayed voltage-dependent K+ current of the type B photoreceptor in the nudibranch Hermissenda crassicornis to a greater extent than an early, rapidly inactivating K+ current (IA). This injection also enhanced the long-lasting depolarization of type B cells after a light step. These findings suggest the involvement of cyclic adenosine monophosphate-dependent phosphorylation in the differential regulation of photoreceptor K+ currents particularly during illumination. On the other hand, conditioning-induced changes in IA may also be regulated by a different type of phosphorylation (for example, Ca2+-dependent). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712553; ALKON, DANIEL L. 1; ACOSTA-URQUIDI, JUAN 1; OLDS, JAMES 1; KUZMA, GREGORY; NEARY, JOSEPH T. 1; Affiliations: 1: Section on Neural Systems, Laboratory of Biophysics, National Institutes of Health, Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: 1/21/1983, Vol. 219 Issue 4582, p303; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MENDELSON, WALLACE B.
AU - CAIN, MICHAEL
AU - COOK, JAMES M.
AU - PAUL, STEVEN M.
AU - SKOLNICK, PHIL
T1 - A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam.
JO - Science
JF - Science
Y1 - 1983/01/28/
VL - 219
IS - 4583
M3 - Article
SP - 414
EP - 416
SN - 00368075
AB - The benzodiazepine receptor antagonist 3-hydroxymethyl-p-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency ift the rat. Furthermore, at a low dose that by itselfdoes not affect sleep, 3-hydroxymethyl-f-carboline blocks sleep induction by a large dosf of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712596; MENDELSON, WALLACE B. 1; CAIN, MICHAEL 2; COOK, JAMES M. 2; PAUL, STEVEN M. 3; SKOLNICK, PHIL 4; Affiliations: 1: Adult Psychiatry Branch and Unit on Sleep Studies, Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Chemistry, University of Wisconsin, Milwaukee 53201; 3: Neuroscience Branch, National Institute of Mental Health; 4: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 1/28/1983, Vol. 219 Issue 4583, p414; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buchsbaum, Monte S.
AU - Haier, Richard J.
T1 - PSYCHOPATHOLOGY: BIOLOGICAL APPROACHES.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1983/02//
VL - 34
IS - 1
M3 - Article
SP - 401
PB - Annual Reviews Inc.
SN - 00664308
N1 - Accession Number: 11267640; Buchsbaum, Monte S. 1 Haier, Richard J. 2,3; Affiliation: 1: Section on Clinical Psychophysiology, National Institute of Mental Health, Bethesda, Maryland 20205. 2: Section of Psychiatry and Human Behavior, Brown University. 3: Butler Hospital, Providence, Rhode Island 02906.; Source Info: 1983, Vol. 34 Issue 1, p401; Number of Pages: 30p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bolen, J. B.
AU - Tribble, J. L.
T1 - Delayed hypersensitivity to Staphylococcus aureus in mice: kinetics of induction.
JO - Immunology
JF - Immunology
Y1 - 1983/02//
VL - 48
IS - 2
M3 - Article
SP - 239
EP - 246
PB - Wiley-Blackwell
SN - 00192805
AB - The induction of systemic delayed hypersensitivity to Staphylococcus aureus is dependent on a minimum of two weekly injections of viable bacteria. In vitro lymphocyte stimulation studies show that the spleen acts as a repository for the immunogen-responsive lymphocytes associated with DH. To evaluate the kinetics of induction, mice were given one to three weekly injections of viable S. aureus and the weights, lymphocyte numbers, DNA synthesis and lymphocyte immunogen reactivity of the draining lymph node (DLN), contralateral lymph node (CLN), and spleen (SP) were determined at days 7, 14 and 21 post injection. The staphylococcal immunogens included whole cell sonicate, cell wall, cell membrane, protein A, lipoteichoic acid, teichoic acid and purified membrane proteins. A single injection resulted in an increase in organ weight, lymphocyte numbers and DNA synthesis of the DLN. This was accompanied by lymphocyte responsiveness to all immunogens. There was an increase in spleen weight and lymphocyte numbers without an appreciable increase in DNA synthesis. Spleen lymphocytes showed no increase in immunogen responsiveness. A second injection maintained the increased weight, lymphocyte numbers and DNA synthesis of the DLN but resulted in a suppression of lymphocyte responsiveness to all immunogens. Splenic lymphocytes showed in vitro reactivity to all immunogens. This was accompanied by an increase in lymphocytes and mitogenic responsiveness without in vivo mitosis. The third injection maintained suppression of DLN cells and further stimulated those of the spleen. The splenic lymphocytes were hyper-reactive to B-lymphocyte and T-lymphocyte mitogens and showed an increased rate of DNA synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DELAYED hypersensitivity
KW - CELLULAR immunity
KW - STAPHYLOCOCCUS aureus
KW - DNA synthesis
KW - LYMPHOCYTES
KW - BACTERIOLOGY
N1 - Accession Number: 13991090; Bolen, J. B. 1 Tribble, J. L. 2; Affiliation: 1: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 2: Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana, U.S.A.; Source Info: Feb83, Vol. 48 Issue 2, p239; Subject Term: DELAYED hypersensitivity; Subject Term: CELLULAR immunity; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: DNA synthesis; Subject Term: LYMPHOCYTES; Subject Term: BACTERIOLOGY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breathnach, Stephen M.
AU - Melrose, Susan M.
AU - Bhogal, Balbir
AU - De Beer, Frederick C.
AU - Black, Martin M.
AU - Pepys, Mark B.
T1 - Immunohistochemical Studies of Amyloid P Component Distribution in Normal Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/02//
VL - 80
IS - 2
M3 - Article
SP - 86
EP - 90
SN - 0022202X
AB - The distribution of amyloid P component (AP) in normal human skin was investigated by a light and electron microscopic immunoperoxidase technique, using antibodies to serum amyloid P component (SAP). AP, or an immunologically cross-reactive protein, was found to be specifically localized to the microfibrils of papillary oxytalan fibers and to the peripheral microfibrillar mantle surrounding the elastin core of mature elastic fibers in the reticular dermis; collagen fibers were not stained with anti-SAP, AP was not detected in the dermal-epidermal basement membrane or in the basement membranes surrounding dermal papillary blood vessels and eccrine structures. These findings, which establish the detailed distribution of normal tissue AP in the skin, provide a basis for further studies of the function and behavior of this protein in health and disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMYLOID
KW - SKIN
KW - IMMUNOHISTOCHEMISTRY
KW - IMMUNOGLOBULINS
KW - COLLAGEN
KW - IMMUNOENZYME technique
N1 - Accession Number: 12531608; Breathnach, Stephen M. 1 Melrose, Susan M. 2 Bhogal, Balbir 3 De Beer, Frederick C. 4 Black, Martin M. 3 Pepys, Mark B. 4; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205. 2: Department of Histopathology, Royal Postgraduate Medical School London, U. K. 3: Institute of Dermatology, St. John's Hospital for Diseases of Skin, London. 4: Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School London, U. K.; Source Info: Feb83, Vol. 80 Issue 2, p86; Subject Term: AMYLOID; Subject Term: SKIN; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: IMMUNOGLOBULINS; Subject Term: COLLAGEN; Subject Term: IMMUNOENZYME technique; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12531608
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SPECTOR, ILAN
AU - SHOCHET, NAVA R.
AU - KASHMAN, YOEL
AU - GROWEISS, AMIRAM
T1 - Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells.
JO - Science
JF - Science
Y1 - 1983/02/04/
VL - 219
IS - 4584
M3 - Article
SP - 493
EP - 495
SN - 00368075
AB - Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recentlyfrom the Red Sea sponge Latrunculia magnifica. The effects of the se toxins on cultured mouse neuroblastoma andfibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712628; SPECTOR, ILAN 1; SHOCHET, NAVA R. 1; KASHMAN, YOEL 2; GROWEISS, AMIRAM 2; Affiliations: 1: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Departmenzt of Organic Chemistry, Tel-Aviv University, Tel-Aviv, Israel; Issue Info: 2/ 4/1983, Vol. 219 Issue 4584, p493; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JOSEPHS, STEVEN F.
AU - FAVERA, RICCARDO DALLA
AU - GELMANN, EDWARD P.
AU - GALLO, ROBERT C.
AU - WONG-STAAL, FLOSSIE
T1 - 5' Viral and Human Cellular Sequences Corresponding to the Transforming Gene of Simian Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1983/02/04/
VL - 219
IS - 4584
M3 - Article
SP - 503
EP - 505
SN - 00368075
AB - The 5' nucleotide sequences of the transforming gene of simian sarcoma virus (v-sis) and its human cellular homolog (c-sis) were compared. A short homology was found between helper virus and cellular DNA sequences at the junction of v-sis and c-sis, which may have had a role in the original recombination event leading to the generation of simian sarcoma virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712632; JOSEPHS, STEVEN F. 1; FAVERA, RICCARDO DALLA 1; GELMANN, EDWARD P. 1; GALLO, ROBERT C. 1; WONG-STAAL, FLOSSIE 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/ 4/1983, Vol. 219 Issue 4584, p503; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weiher, Hans
AU - König, Monika
AU - Gruss, Peter
T1 - Multiple Point Mutations Affecting the Simian Virus 40 Enhancer.
JO - Science
JF - Science
Y1 - 1983/02/11/
VL - 219
IS - 4585
M3 - Article
SP - 626
EP - 631
SN - 00368075
N1 - Accession Number: 84712645; Weiher, Hans 1; König, Monika 2; Gruss, Peter 3; Affiliations: 1: Postdoctoral fellow, Institute of Microbiology, University of Heidelberg; 2: Microbiologist, Laboratory of Molecular Virology, National Institutes of Health, Bethesda, Maryland 20205; 3: Visiting scientist, Laboratory of Molecular Virology, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 2/11/1983, Vol. 219 Issue 4585, p626; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MUSCHEL, RUTH J.
AU - KHOURY, GEORGE
AU - LEBOWITZ, PAUL
AU - KOLLER, RICHARD
AU - DHAR, RAVI
T1 - The Human c-ras1H Oncogene: A Mutation in Normal and Neoplastic Tissue from the Same Patient.
JO - Science
JF - Science
Y1 - 1983/02/18/
VL - 219
IS - 4586
M3 - Article
SP - 853
EP - 856
SN - 00368075
AB - The c-ras1H oncogene can be distinguished from its normal cellular counterpart by the loss of a restriction endonuclease site. This sequence alteration is the basis of a rapid screening methodfor the presence of this oncogene. DNA'sfrom 34 individuals were screened by this method, and all were homozygous for the normal allele. In contrast, DNA from a patient's bladder tumor, as well as DNA from his normal bladder and leukocytes, were heterozygous at that restriction endonuclease site. Further restriction enzyme mapping pinpointed the change in the mutant allele as being one of two nucleotides, either of which would change the 12th amino acid (glycine) in the normal c-ras1H gene product. Point mutations in the codonfor this amino acid have previously been described in a bladder tumor cell line and in the viral oncogene v-rasH. These results indicate that the patient carried a cras, H oncogene in his germ line, raising the possibility that the c-ras1H oncogene confers a predisposition to neoplasia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712710; MUSCHEL, RUTH J. 1; KHOURY, GEORGE 1; LEBOWITZ, PAUL 2; KOLLER, RICHARD 3; DHAR, RAVI 3; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Medicine, Yale University Medical School, New Haven, Connecticut 06510; 3: Laboratory of Molecular Virology, National Cancer Institute; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p853; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - POPOVIC, M.
AU - SARIN, P. S.
AU - ROBERT-GURROFF, M.
AU - KALYANARAMAN, V. S.
AU - MANN, D.
AU - MINOWADA, J.
AU - GALLO, R. C.
T1 - Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus).
JO - Science
JF - Science
Y1 - 1983/02/18/
VL - 219
IS - 4586
M3 - Article
SP - 856
EP - 859
SN - 00368075
AB - Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712711; POPOVIC, M. 1; SARIN, P. S. 1; ROBERT-GURROFF, M. 1; KALYANARAMAN, V. S. 2; MANN, D. 3; MINOWADA, J. 4; GALLO, R. C. 5; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland 20895; 3: Division of Cancer Biology and Diagnosis, National Cancer Institute; 4: Department of Immunology, Roswell Park Memorial Institute, Buffalo, New York 14263; 5: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p856; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PRESSER, HARRIET B.
AU - CAIN, VIRGINIA S.
T1 - Shift Work Among Dual-Earner Couples with Children.
JO - Science
JF - Science
Y1 - 1983/02/18/
VL - 219
IS - 4586
M3 - Article
SP - 876
EP - 879
SN - 00368075
AB - In a 1980 sample of U.S. nonfarm households with children and with both spouses employed full time, one-third of the couples included at least one spouse who worked other than a regular day shift. In about one-tenth of the couples the spouses worked entirely different shifts with no overlap in hours. These findings are linked to an earlier study which showed a high prevalence of child care by employed fathers whose wives were employed in certain occupations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712719; PRESSER, HARRIET B. 1; CAIN, VIRGINIA S. 2; Affiliations: 1: Department of Sociology, University of Maryland, College Park 20742; 2: Department of Sociology, University of Maryland, and Center, Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/18/1983, Vol. 219 Issue 4586, p876; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - OLDHAM, ROBERT R.
T1 - Toxic Effects of Interferon.
JO - Science
JF - Science
Y1 - 1983/02/25/
VL - 219
IS - 4587
M3 - Article
SP - 902
EP - 902
SN - 00368075
N1 - Accession Number: 84712722; OLDHAM, ROBERT R. 1; Affiliations: 1: Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Marylaind 21701; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p902; Number of Pages: 6/7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DALLA-FAVERA, RICCARDO
AU - MARTINOTII, STEFANO
AU - GALLO, ROBERT C.
AU - ERIKSON, JAN
AU - CROCE, CARLO M.
T1 - Translocation and Rearrangements of the c-myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas.
JO - Science
JF - Science
Y1 - 1983/02/25/
VL - 219
IS - 4587
M3 - Article
SP - 963
EP - 967
SN - 00368075
AB - The locus for the cellular myc (c-myc) oncogene in humans is located on the region of chromosome 8 that is translocated to chromosome 14 in cellsfrom most undifferentiated B-cell lymphomas. It is shown in this study that the c-myc locus is rearranged in S out of 15 cell lines from patients with undifferentiated B-cell lymphomas, and that the rearrangement involves a region at the 5' side of an apparently intact c-myc gene. In at least three patients, this rearranged region appears to contain immunoglobulin heavy chain μsequences that are located on chromosome 14. The data indicate that this region contains the crossover point between chromosomes 8 and 14. The break point can occur at different positions on both chromosomes among individual cell lines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712752; DALLA-FAVERA, RICCARDO 1; MARTINOTII, STEFANO 1; GALLO, ROBERT C. 1; ERIKSON, JAN 2; CROCE, CARLO M. 2; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p963; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MUKHERJEE, DIANE C.
AU - AGRAWAL, ARUN K.
AU - MANJUNATH, RAMANATHAPURAM
AU - MUKHERJEE, ANIL B.
T1 - Suppression of Epididymal Sperm Antigenicity in the Rabbit by Uteroglobin and Transglutaminase in vitro.
JO - Science
JF - Science
Y1 - 1983/02/25/
VL - 219
IS - 4587
M3 - Article
SP - 989
EP - 991
SN - 00368075
AB - There is evidence that the mammalian female genital tract is capable oJ responding immunologically when challenged with alloantigens. The antigenic properties of male gametes have been well delineated. However, it is only ralrely that a female mammal ever responds immunologically to the male gametic antigens as a result of coitus. When a proposed mechanism of suppression of antigenicity of epididymal spermatozoa was tested experimentally, the results indicated that two proteins (uteroglobin and transglutaminase) present in the prostate may be responsible for suppressing sperm antigenicity in the rabbit. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712764; MUKHERJEE, DIANE C. 1,2; AGRAWAL, ARUN K. 1,2; MANJUNATH, RAMANATHAPURAM 1,2; MUKHERJEE, ANIL B. 1,2; Affiliations: 1: Section on Molecular and Developmental Genetics, Pregnancy Research Branch; 2: National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 2/25/1983, Vol. 219 Issue 4587, p989; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Beebe, Gilbert W.
AU - Yankuer, Alfred
T1 - Long-Term Follow-Up Is a Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/03//
VL - 73
IS - 3
M3 - Editorial
SP - 245
EP - 248
PB - American Public Health Association
SN - 00900036
AB - This article focuses on problems in conducting medical follow-up and epidemiologic studies in the U.S. It is difficult and impractical to link events in the life hisotry of an individual in order to advance medical science, despite of the allocation of medical care funds and advances in technology. Difficulties may be experienced by researchers of long-term follow-up studies, especially if outcomes and events are at issue. Researchers must have access to individuals involved in order to obtain responses to a questionnaire or interview or to perform spoecific examination procedure.
KW - MEDICAL research
KW - EPIDEMIOLOGY -- Research
KW - MEDICAL sciences
KW - OUTCOME assessment (Medical care)
KW - MEDICAL technology
KW - UNITED States
N1 - Accession Number: 4948743; Beebe, Gilbert W. 1 Yankuer, Alfred; Affiliation: 1: Expert Scientist, Clinical Epidemiology Branch, National Cancer Institute, Room 5A21 Landow Building, Bethesda, MD 20205; Source Info: Mar1983, Vol. 73 Issue 3, p245; Subject Term: MEDICAL research; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: MEDICAL sciences; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL technology; Subject Term: UNITED States; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Madans, Jennifer
AU - Kleinman, Joel C.
AU - Cornoni-Huntley, Joan
T1 - The Relationship between Hip Fracture and Water Fluoridation: An Analysis of National Data.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/03//
VL - 73
IS - 3
M3 - Article
SP - 296
EP - 298
PB - American Public Health Association
SN - 00900036
AB - Abstract: Data from the 1973-1977 National Health Interview Surveys were used to determine whether water fluoridation prevents hip fractures related to osteoporosis, No protective effect was found for fluoride levels of 0.7 ppm the level recommended for the prevention of dental caries There are some indications that higher concentrations of fluoride might have a protective effect for groups with a high incidence of osteoporosis. However. no determination of the actual levels needed or the possible adverse effects of high water fluoride levels could be made. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURVEYS
KW - WATER fluoridation
KW - FRACTURES
KW - PELVIC bones
KW - OSTEOPOROSIS
N1 - Accession Number: 4948784; Madans, Jennifer 1 Kleinman, Joel C. 1 Cornoni-Huntley, Joan 2; Affiliation: 1: Division of Analysis, National Center for Health Statistics, FCB#2, Room 2-27, 3700 East-West Highway, Hyattsville, MD 20782 2: National Institute on Aging; Source Info: Mar1983, Vol. 73 Issue 3, p296; Subject Term: SURVEYS; Subject Term: WATER fluoridation; Subject Term: FRACTURES; Subject Term: PELVIC bones; Subject Term: OSTEOPOROSIS; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roder, J. C.
AU - Todd, R. F.
AU - Rubin, J. P.
AU - Haliotis, Tina
AU - Helfand, S. L.
AU - Werkmeister, J.
AU - Pross, H. F.
AU - Boxer, L. A.
AU - Schlossman, S. F.
AU - Fauci, A. S.
T1 - The Chediak-Higashi gene in humans. III. Studies on the mechanisms of NK impairment.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/03//
VL - 51
IS - 3
M3 - Article
SP - 359
EP - 368
PB - Wiley-Blackwell
SN - 00099104
AB - Lymphocytes from six Chediak Higashi (CH) patients were markedly depressed in their ability to lyse tumour cell targets in both 51Cr release and single cell cytotoxicity assays. The frequency of lymphocytes bearing the OKM1 marker and the frequency of T3+, T4+, T8+, la-, Mol+, Mo2+ and BI+ cells was normal among sheep erythrocyte rosetting (E+ ) and non-resetting (E-) peripheral blood leucocytes analysed by flow cytofluorography. Cells expressing the NK shared markers. OKMI mac-1, FcR, and the characteristic large granular lymphocyte (LGL) morphology of NK cells were also present in normal numbers in the highly enriched NK fraction separated on Percoll density gradients. This fraction did not contain detectable numbers of cells expressing the Mo2 marker of human monocytes. Therefore most of the cells stained by monoclonal OKMI and mac-1 in this fraction are likely NK cells, rather than monocytes. and we conclude that the size of the NK pool in CH patients is probably normal. The capacity of CH lymphocytes to recognize anti bind to tumour cells was also normal as was the subsequent burst at oxygen intermediates produced by the NK cells in a chemiluminenscence assay We have shown elsewhere that O2 generation is directly involved in activating subsequent steps in the NK cytolytic pathway. These results suggest that NK cells in CH patients are present in normal frequency but are blocked at some post-recognition, post-activation step in the cytolytic pathway subsequent to the burst of oxygen intermediates but preceding the lethal hit. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - TUMORS
KW - KILLER cells
KW - SHEEP as laboratory animals
KW - ERYTHROCYTES
KW - LEUCOCYTES
N1 - Accession Number: 16253512; Roder, J. C. 1,2 Todd, R. F. 3 Rubin, J. P. 1,2,4 Haliotis, Tina 1,2 Helfand, S. L. 1,2 Werkmeister, J. 1,2,4 Pross, H. F. 1,2,4 Boxer, L. A. 5 Schlossman, S. F. 3 Fauci, A. S. 6; Affiliation: 1: Department of Microbiology,Immunology, Queens University, Kingston, Ontario, Canada 2: Department of Immunology, Queens University, Kingston, Ontario, Canada 3: Division of Tumor Immunology, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 4: Department of Radiation Oncology, Queens University, Kingston, Ontario, Canada 5: Division of Paediatric Hematology Oncology, Indiana University, School of Medicine, James Witcomb Riley Hospital for Children, Indianapolis, Indiana 6: Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Mar1983, Vol. 51 Issue 3, p359; Subject Term: LYMPHOCYTES; Subject Term: TUMORS; Subject Term: KILLER cells; Subject Term: SHEEP as laboratory animals; Subject Term: ERYTHROCYTES; Subject Term: LEUCOCYTES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jahn, Claus E.
AU - Osborne Jr., James C.
AU - Schaefer, Ernst J.
AU - Brewer Jr, H, Bryan
T1 - Activation of the Enzymic Activity of Hepatic Lipase by Apolipoprotein A-II.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/03//3/1/83
VL - 131
IS - 1
M3 - Article
SP - 25
EP - 29
PB - Wiley-Blackwell
SN - 00142956
AB - Human post-heparin plasma contains two major lipases, lipoprotein lipase and hepatic lipase. Lipoprotein lipase has been investigated extensively and in the presence of a specific activator, apolipoprotein C-II, is of major importance in modulating the hydrolysis of triacylglycerol rich lipoprotein particles in plasma. The metabolic function and regulation of hepatic lipase is less well established. We have reported previously that apolipoprotein A-II (apoA-II) in vitro increased the activity of hepatic lipase by 3.6-fold [Jahn et al. (198l) FEBS Lett. 131, 366–368]. We have extended these studies and report here the effects of normal plasma, very low density, low density and high density lipoproteins (VLDL, LDL and HDL) and apolipoproteins A-I, A-II, C-I, C-II and C-III on hepatic lipase enzymic activity. Normal plasma and HDL activated hepatic lipase by 255 ± 53% (n = 9) and 288 ± 55% (n = 7) respectively, whereas VLDL inhibited hepatic lipase to 25% and LDL did not affect hepatic lipase enzymic activity (n = 7). Isolated apoA-I, apoC-I, apoC-II, and apoC-III inhibited hepatic lipase enzymic activity to 25 ± 8% (n = 5), 25 ± 15% (n = 5), 23 ± 7% (n = 5) and 13 ± 10% (n = 5) of the basal level. ApoA-II recombined with HDL lipids activated by 273 ± 42% (n = 5) whereas apoC-III recombined with HDL lipids inhibited hepatic lipase to 30% of basal activity. Activation of hepatic lipase by apoA-II was dependent on temperature and pH, with maximal activation (5.75-fold over basal levels) occurring at pH 7.5 and 37°C. The addition of lipid-free apoA-11 10 min after the hydrolysis of triacylglycerol by hepatic lipase had begun resulted in an increase in rate from 1.9 nmol min-1 ml-1 to 7.0 nmol min-1 ml-1. The rate observed by the addition of apoA-II before the start of the reaction was 9.5 nmol min-1 ml-1. These results are consistent with the concept that apoA-II modulates the enzymic activity of hepatic lipase, and may play a role in vivo in the regulation of hepatic lipase activity and HDL lipoprotein metabolism. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPARIN
KW - LIPASES
KW - LIPOPROTEIN lipase
KW - APOLIPOPROTEINS
KW - HYDROLYSIS
KW - LIPOPROTEINS
N1 - Accession Number: 15818091; Jahn, Claus E. 1 Osborne Jr., James C. 1 Schaefer, Ernst J. 1 Brewer Jr, H, Bryan; Affiliation: 1: Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 3/1/83, Vol. 131 Issue 1, p25; Subject Term: HEPARIN; Subject Term: LIPASES; Subject Term: LIPOPROTEIN lipase; Subject Term: APOLIPOPROTEINS; Subject Term: HYDROLYSIS; Subject Term: LIPOPROTEINS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rousset, Bernard
AU - Bernier-Valentin, Françoise
AU - Wolff, Jan
AU - Roux, Bernard
T1 - Alterations in Tubulin Immunoreactivity; Relation to Secondary Structure.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/03//3/1/83
VL - 131
IS - 1
M3 - Article
SP - 31
EP - 39
PB - Wiley-Blackwell
SN - 00142956
AB - The immunoreactivity of tubulin varies with the conditions of preparation and storage of the protein. Four different antisera to tubulin detected less than or about 10% of the tubulin present in purified rat brain microtubule protein either immediately after preparation or after storage at -196°C. Addition of salt to the storage buffer led to a partial recovery of immunoreactivity. After storage at -20°C or after transfer from -196°C to -20°C, the recovery of tubulin immunoreactivity varied with the concentration of microtubule protein. At concentrations higher than 2.0–2.5 mg/ml, tubulin remained non-immunoreactive. On decreasing the protein concentration, there was a progressive recovery of the immunoreactivity. Addition of salt to the storage buffer led to a full recovery whatever the protein concentration. Storage in 2 M glycerol prevented immunoreactivity in all the conditions. Phosphocellulose chromatography of microtubule protein lacking immunoreactivity yielded a pure tubulin that was fully immunoassayable. Transfer of microtubule protein from -20°C to -196°C led to a significant decrease of the amount of immunoassayable tubulin indicating that the alterations of tubulin immunoreactivity are reversible. Immunoreactivity of tubulin present in freshly prepared crude rat brain 100000 x g supernatant was also incompletely immunoreactive and increased after freezing at -20°C. Circular dichroic spectra showed that freezing at -20°C decreased the content of a helix from 41% (at -196°C) to 28% in purified microtubule protein. The percentage a helix was low in buffers of high ionic strength and high in the presence of glycerol irrespective of the storage temperature. Thus, the a helix content showed an inverse relationship to immunoreactivity and the availability of antigenic sites seems to be related to the conformation of tubulin. Although the ability of microtubule protein to polymerize was maintained after storage at -196°C and decreased after storage at -20°C, there was no direct relationship between immunoreactivity and the polymerization properties of tubulin. Our results show that care should be taken in the preparation of tubulin samples to be assayed by immunological techniques. Glycerol, which is often used to prepare and store tubulin, prevents the ability of tubulin to react with specific antibodies. Alterations of the availability of antigenic sites, observed in the presence of glycerol or salt or after freezing, seem to be related to changes of the conformation of tubulin. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBULINS
KW - PROTEINS
KW - IMMUNE serums
KW - IMMUNE response
KW - IMMUNOGLOBULINS
KW - MICROTUBULES
N1 - Accession Number: 15818094; Rousset, Bernard 1 Bernier-Valentin, Françoise 1 Wolff, Jan 2 Roux, Bernard 3; Affiliation: 1: Groupe de Physiopathologie Endocrinienne, Unité 197 de l'Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Alexis Carrel, Rue Guillaume Paradin, F-69372 Lyon-Cedex-2, France 2: National Institutes of Health, 900 Rockville Pike, Bethesda, MD, USA 20205 3: Laboratoire de Physico-Chimie Biologique, Université Claude, Bernard, 43, boulevard du 11 Novembre 1918, F-69100 Villeurbanne, France; Source Info: 3/1/83, Vol. 131 Issue 1, p31; Subject Term: TUBULINS; Subject Term: PROTEINS; Subject Term: IMMUNE serums; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULINS; Subject Term: MICROTUBULES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breslow, N.E.
AU - Lubin, J. H.
AU - Marek, P.
AU - Langholz, B.
T1 - Multiplicative Models and Cohort Analysis.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1983/03//
VL - 78
IS - 381
M3 - Article
SP - 1
SN - 01621459
AB - Three methods of cohort analysis are presented for a statistical model wherein the explanatory or exposure variables act multiplicatively on age x calendar year specific death rates. The first method, which assumes that the baseline rates are known from national vital statistics, is a multiple regression analysis of the standardized mortality ratio. The second method is a variant of Cox's proportional hazards analysis in which the baseline rates are treated as unknown nuisance parameters. The third method consists of case-control sampling from the risk sets formed in the course of applying Cox's model. It requires substantially less computation than do the other two. In illustrative analysis of respiratory cancer deaths among a cohort of smelter workers, all three approaches yield roughly equivalent estimates of the relative risk associated with arsenic exposure. The discussion centers on the tradeoff between efficiency and bias in the selection of a particular method of analysis, and on practical issues that arise in applications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICS
KW - MULTIVARIATE analysis
KW - REGRESSION analysis
KW - SAMPLING (Statistics)
KW - MATHEMATICAL models
KW - COHORT analysis
KW - MORTALITY
KW - HAZARDS
KW - Case-control studies
KW - Cohort studies
KW - Efficiency
KW - Nonlinear regression
KW - Proportional hazards
KW - Proportional mortality ratio
KW - Standardized mortality ratio.
N1 - Accession Number: 4607597; Breslow, N.E. 1; Lubin, J. H. 2; Marek, P. 3; Langholz, B.; Affiliations: 1: Professor, Department of Biostatistics SC-32, University of Washington, Seattle, WA 98195.; 2: The Environmental Epidemiology Branch, National Cancer Institute, 3C07 Landow Bldg., Bethesda, MD 20205.; 3: Scientific Programmer, the Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104.; Issue Info: Mar1983, Vol. 78 Issue 381, p1; Thesaurus Term: STATISTICS; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: REGRESSION analysis; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL models; Subject Term: COHORT analysis; Subject Term: MORTALITY; Subject Term: HAZARDS; Author-Supplied Keyword: Case-control studies; Author-Supplied Keyword: Cohort studies; Author-Supplied Keyword: Efficiency; Author-Supplied Keyword: Nonlinear regression; Author-Supplied Keyword: Proportional hazards; Author-Supplied Keyword: Proportional mortality ratio; Author-Supplied Keyword: Standardized mortality ratio.; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Brown, Kenneth G.
T1 - Sub-Balanced Data and the Mixed Analysis of Variance.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1983/03//
VL - 78
IS - 381
M3 - Article
SP - 162
SN - 01621459
AB - In the mixed model, it is well known that balanced data are a sufficient condition for an ANOVA with terms that are independent multiples of chi-squared variables (called a proper ANOVA). In this article a weaker condition, which is both necessary and sufficient, is determined and shown to be equivalent to what is defined here as sub-balanced random effects, a condition easily checked in practice. The usual method of generating an ANOVA by fitting sums of squares for a given ordering of the effects in the model is sometimes inadequate with sub-balanced data, requiring instead a spectral decomposition of the covariance matrix. An example is given. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of variance
KW - MATHEMATICAL models
KW - PROBABILITY theory
KW - STATISTICS
KW - VARIABLES (Mathematics)
KW - DECOMPOSITION (Mathematics)
KW - RANDOM vibration
KW - MATRICES
KW - Analysis of variance
KW - Balanced data
KW - Mixed model.
KW - Sub-balanced data
KW - Variance components
N1 - Accession Number: 4607873; Brown, Kenneth G. 1; Affiliations: 1: Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 277089.; Issue Info: Mar1983, Vol. 78 Issue 381, p162; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: PROBABILITY theory; Thesaurus Term: STATISTICS; Subject Term: VARIABLES (Mathematics); Subject Term: DECOMPOSITION (Mathematics); Subject Term: RANDOM vibration; Subject Term: MATRICES; Author-Supplied Keyword: Analysis of variance; Author-Supplied Keyword: Balanced data; Author-Supplied Keyword: Mixed model.; Author-Supplied Keyword: Sub-balanced data; Author-Supplied Keyword: Variance components; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Abbott, Robert D.
T1 - Statistics for Biologists/ Statistical Methods in Biology (2nd ed.) (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1983/03//
VL - 78
IS - 381
M3 - Book Review
SP - 207
SN - 01621459
AB - Reviews two books. "Statistics for Biologists," by D.J. Finney; "Statistical Methods in Biology," 2nd ed., by N.T.J. Bailey.
KW - NONFICTION
KW - FINNEY, D. J.
KW - BAILEY, N. T. J.
KW - STATISTICS for Biologists (Book)
KW - STATISTICAL Methods in Biology (Book)
N1 - Accession Number: 4608189; Abbott, Robert D. 1; Affiliations: 1: National Heart, Lung, And Blood Institute.; Issue Info: Mar1983, Vol. 78 Issue 381, p207; Subject Term: NONFICTION; Reviews & Products: STATISTICS for Biologists (Book); Reviews & Products: STATISTICAL Methods in Biology (Book); People: FINNEY, D. J.; People: BAILEY, N. T. J.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hoel, David G.
AU - Kaplan, Norman L.
AU - Anderson, Marshall W.
T1 - Implication of Nonlinear Kinetics on Risk Estimation in Carcinogenesis.
JO - Science
JF - Science
Y1 - 1983/03/04/
VL - 219
IS - 4588
M3 - Article
SP - 1032
EP - 1037
SN - 00368075
N1 - Accession Number: 84712775; Hoel, David G. 1; Kaplan, Norman L. 2; Anderson, Marshall W. 3; Affiliations: 1: Director, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 2: A mathematician, Statistics and Biomathematics Branch, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 3: A Senior Research Scientist, Molecular and Comparative Pharmacology Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park; Issue Info: 3/ 4/1983, Vol. 219 Issue 4588, p1032; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SPORN, MICHAEL B.
AU - ROBERTS, ANITA B.
AU - SHULL, JAMES H.
AU - SMITH, JOSEPH M.
AU - WARD, JERROLD M.
AU - SODEK, JARO
T1 - Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in vivo.
JO - Science
JF - Science
Y1 - 1983/03/18/
VL - 219
IS - 4590
M3 - Article
SP - 1329
EP - 1331
SN - 00368075
AB - Transforming growth factors, which are polypeptides that induce the transformed phenotype in nonneoplastic cells, have been isolated in bulk amounts from bovine salivary gland and kidney. In experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers. These studies thus show an effect of an isolated transforming growth factor in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84712887; SPORN, MICHAEL B. 1; ROBERTS, ANITA B. 1; SHULL, JAMES H. 1; SMITH, JOSEPH M. 1; WARD, JERROLD M. 1; SODEK, JARO 2; Affiliations: 1: National Cancer Institute, Bethesda, Maryland, 20205; 2: National Institute of Dental Research, Bethesda, Maryland, 20205; Issue Info: 3/18/1983, Vol. 219 Issue 4590, p1329; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schlesinger, Herbert J.
AU - Mumford, Emily
AU - Glass, Gene V.
AU - Patrick, Cathleen
AU - Sharfstein, Steven
T1 - Mental Health Treatment and Medical Care Utilization in a Fee-For-Service System: Outpatient Mental Health Treatment Following the Onset of a Chronic Disease.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/04//
VL - 73
IS - 4
M3 - Article
SP - 422
EP - 429
PB - American Public Health Association
SN - 00900036
AB - Abstract: Charges for medical services of persons covered by the Blue Cross/Blue Shield Federal Employees Program from 1974 through 1978 who were first diagnosed as having one of four chronic diseases in 1975 and within one year began mental health treatment (MHT) were compared with persons who also were firm diagnosed as having one of these diseases in 1975 but had no subsequent MHT. In the third year following the diagnosis, those having seven to 20 MHT visits had medical charges $309 lower and those having over 21 MHT visits had medical charges $284 lower than the comparison group. The savings in medical charges over three years of the group having seven to 20 MHT visits were a function of lower use of inpatient services and roughly equaled the cost of 20 MHT visits. Outpatient mental health treatment can be included in a fee-for-service medical care system to improve the quality and appropriateness of care and, if not extensive, may also serve to lower medical care costs. (Am J Public Health 1983: 73:422-429.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MEDICAL care
KW - RURAL health services
KW - CHRONIC diseases
KW - MENTAL health
KW - MENTAL illness -- Treatment
KW - OUTPATIENT medical care
KW - PUBLIC health
N1 - Accession Number: 4949454; Schlesinger, Herbert J. 1 Mumford, Emily 2 Glass, Gene V. 3 Patrick, Cathleen 4 Sharfstein, Steven 5; Affiliation: 1: Professor of Psychiatry, Department of Psychiatry, University of Colorado School of Medicines 4200 E, 9th Avenue, C-270. Denver, CO 80262 and Denver Veterans Administration Medical Center 2: Departments of Psychiatry and Preventive Medicine 3: Department of Psychiatry, University of Colorado School of Medicine 4: School of Education. University of Colorado 5: National Institute of Mental Health; Source Info: Apr1983, Vol. 73 Issue 4, p422; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care; Subject Term: RURAL health services; Subject Term: CHRONIC diseases; Subject Term: MENTAL health; Subject Term: MENTAL illness -- Treatment; Subject Term: OUTPATIENT medical care; Subject Term: PUBLIC health; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JACOBSON, ERIC S.
AU - STRAUS, STEPHEN E.
AU - WHEAT, L. JOSEPH
T1 - Serologic Tests for Histoplasmosis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1983/04//
VL - 98
IS - 4
M3 - Article
SP - 560
EP - 561
SN - 00034819
N1 - Accession Number: 20427588; JACOBSON, ERIC S. 1; STRAUS, STEPHEN E. 2; WHEAT, L. JOSEPH 3; Source Information: Apr83, Vol. 98 Issue 4, p560; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Dean, J. H.
AU - Luster, M. I.
AU - Boorman, G. A.
AU - Lauer, L. D.
AU - Leubke, R. W.
AU - Lawson, Lela
T1 - Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/04//
VL - 52
IS - 1
M3 - Article
SP - 199
EP - 206
PB - Wiley-Blackwell
SN - 00099104
AB - B6C3F1 mice were exposed to two congeners of benzopyrene, either the carcinogen benzo(a)pyrene (B(a)P) or the non-carcinogen benzo(e)pyrene (B(e)P, Exposure of mice to B(a)P resulted in a reduced number of IgM and IgG antibody plaque forming cells (PFC) to the T-dependent (TD) antigen SRBC and IgM PFCs to the T-independent (TI) antigen LPS. The IgM response to hapten conjugated TI antigens was examined using TNP-LPS for reactivity of less mature B cells (BI) and TNP-Ficoll for more mature B cells (B2). Exposure to B(a)P severely depressed the TNP-Ficoll PFC response by up to 77% without altering the TNP-LPS response. These data indicated that exposure to B(a)P alters differentiation and antibody production in mature B cells to both TD and B2 TI antigens. No change in PFC was observed following exposure to B(e)P. Mishell-Dutton co-cultures confirmed that B cells were affected and that T helper cells or suppressor M0 were not involved. Parameters of cell-mediated immunocompetence including delayed cutaneous hypersensitivity to KLH, allograft or tumour cell rejection and susceptibility to Listeria monocytogens were unaltered in B(a)P treated mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOSUPPRESSION
KW - BENZOPYRENE
KW - MICE as laboratory animals
KW - IMMUNE response -- Regulation
KW - LABORATORY animals
KW - IMMUNOGLOBULINS
N1 - Accession Number: 15985508; Dean, J. H. 1 Luster, M. I. 1 Boorman, G. A. 1 Lauer, L. D. 1 Leubke, R. W. 1 Lawson, Lela 1; Affiliation: 1: National Toxicology Program, National Institutes of Environmental Health Sciences, National Institutes of Health, North Carolina, USA.; Source Info: Apr1983, Vol. 52 Issue 1, p199; Subject Term: IMMUNOSUPPRESSION; Subject Term: BENZOPYRENE; Subject Term: MICE as laboratory animals; Subject Term: IMMUNE response -- Regulation; Subject Term: LABORATORY animals; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rölla, Gunnar
AU - Ciardi, Joseph E.
AU - Schultz, Sandra A.
T1 - Adsorption of glucosyltransferase to saliva coated hydroxyapatite.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1983/04//
VL - 91
IS - 2
M3 - Article
SP - 112
EP - 117
SN - 0029845X
AB - Glucosyltransferase (GTF) adsorbed to hydroxyapatite and to saliva costed hydroxyapatite in vitro. Several proteins which are known to be present in the "pellicle" which forms on hydroxyapatite when this mineral is exposed to whole saliva were town to stimulate or inhibit GTF. It is suggested that these proteins may interact with GTF and cause binding of the enzyme to saliva tasted hydroxyapatite. A model is suggested where GTF adsorbed to tooth surface, may induce binding of microorganisms to tooth surfaces. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALIVARY glands
KW - GLYCOSYLTRANSFERASES
KW - ENZYMES
KW - HYDROXYAPATITE
KW - BODY fluids
KW - PROTEINS
KW - pellicle
KW - plaque formation
KW - sucrose.
N1 - Accession Number: 13176661; Rölla, Gunnar 1 Ciardi, Joseph E. 1 Schultz, Sandra A. 1; Affiliation: 1: National Caries Program, National Institute for Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: 1983, Vol. 91 Issue 2, p112; Subject Term: SALIVARY glands; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: ENZYMES; Subject Term: HYDROXYAPATITE; Subject Term: BODY fluids; Subject Term: PROTEINS; Author-Supplied Keyword: pellicle; Author-Supplied Keyword: plaque formation; Author-Supplied Keyword: sucrose.; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42332-019
AN - 2013-42332-019
AU - Shore, Milton F.
T1 - Review of Unclaimed children: The failure of public responsibility to children in need of mental health services and Making policies for children: A study of the federal process.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1983/04//
VL - 53
IS - 2
SP - 363
EP - 365
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42332-019. Partial author list: First Author & Affiliation: Shore, Milton F.; Intramural Research Program, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Community Mental Health; Foster Care; Mental Health Services; Policy Making. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Knitzer, Jane. Unclaimed children: The failure of public responsibility to children in need of mental health services=145 pp. $10.50. Children's Defense Fund, Washington, D.C; 1982. Hayes, Cheryl D. (Ed). Making policies for children: A study of the federal process=265 pp. $13.95. National Academy Press, Washington, D.C; 1982. Page Count: 3. Issue Publication Date: Apr, 1983.
AB - Reviews the books, Unclaimed Children: The Failure of Public Responsibility to Children in Need of Mental Health Services by Jane Knilzer (1982) and Making Policies for Children: A Study of the Federal Process edited by Cheryl D . Hayes (1982). These books address the issues of needs and social policy to meet these needs. Both agree on the importance of the role of government in developing high quality service systems for children. Jane Knitzer's book, is a remarkable documentation of the failure spelled out in its subtitle. Mental health is defined by the author broadly enough so as to encompass prevention as well as treatment, services to education, and foster care, as well as autonomous mental health services in settings such as community mental health centers. It is a reasoned , clear, unemotional work, but one which is highly committed to action for children. The volume edited by Cheryl D. Hayes, a National Research Council panel report for the Study of the Policy Formation Process, tries to conceptualize the development of federal legislation for children. Indeed, the report can be seen as an effort to try to bring some sort of rationality to what has been basically an irrational and unplanned process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health
KW - foster care
KW - mental health services
KW - social policy
KW - policy making
KW - 1983
KW - Community Mental Health
KW - Foster Care
KW - Mental Health Services
KW - Policy Making
KW - 1983
U2 - Knitzer, Jane. (1982); Unclaimed children: The failure of public responsibility to children in need of mental health services; 145 pp. $10.50. Children's Defense Fund, Washington, D.C
U2 - Hayes, Cheryl D. (Ed). (1982); Making policies for children: A study of the federal process; 265 pp. $13.95. National Academy Press, Washington, D.C
DO - 10.1037/h0098799
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42332-019&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Goldman, Robert C.
AU - Trus, Benes L.
AU - Leive, Loretta
T1 - Quantitative Double-Label Radiography of Two-Dimensional Protein Gels Using Color Negative Film and Computer Analysis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/04/05/
VL - 131
IS - 3
M3 - Article
SP - 473
EP - 480
PB - Wiley-Blackwell
SN - 00142956
AB - We have devised a method of data collection and computer analysis which allows utilization of the resolving power of two-dimensional gel electrophoresis of proteins, in conjunction with the versatility of using two different radionuclides simultaneously. Cultures of Escherichia coli growing with exponential growth rate constants (μ) of 0.32 and 1.43 were labeled with [3H]leucine and [14C]leucine, respectively; these samples were mixed, and cell protein was separated on a two-dimensional gel. Spacial and quantitative data for both radionuclides were recorded on color negative film by radiographic exposure. Data for 14C alone were then collected photographically from the red-light- sensitive layer of the film using a red filter, while data for 3H and spillover of 14C were collected photographically from the blue-light-sensitive layer using a blue filter. These two data sets were analyzed by CINT, a computer program for analysis of two-dimensional gels, and quantitative data for 3H were calculated after determination of spillover of' 14C in a manner analogous to quantification of 3H and 14C by liquid scintillation counting. Quantitative data from over 1000 protein spots representing from 0.002% to 10 % of the total 3H or 14C, respectively, are available in a matter of hours. We have used this method to analyze the effect of growth rate and medium composition on the relative levels of individual proteins in a pathogenic strain of E. coli which contains group 111 O-antigen. As expected, the relative levels of aminoacyl-tRNA synthetases, protein chain elongation factors, ribosomal proteins, and the α- subunit of RNA polymerase are all increased with increased growth rate; the magnitude of these changes agreed with previous data derived using other strains of E coli. Alterations in the levels of other proteins identified on the two-dimensional gels could be interpreted in terms of changes in medium composition. When compared to manual data collection by excising radiolabeled proteins and quantifying 3H and 14C in a liquid scintillation counter following combustion to H2O and CO2, respectively, this new method of data collection and computer analysis increases the resolution of data collection and decreases the time involved from days to hours. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOGRAPHY
KW - PROTEINS
KW - COMPUTER software
KW - COMPUTER files
KW - X-rays
KW - ELECTROPHORESIS
KW - TRANSFER RNA
N1 - Accession Number: 15818052; Goldman, Robert C. 1 Trus, Benes L. 1 Leive, Loretta 2; Affiliation: 1: National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda Maryland, USA 20205. 2: Computer Systems Laboratory, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205.; Source Info: 4/5/83, Vol. 131 Issue 3, p473; Subject Term: RADIOGRAPHY; Subject Term: PROTEINS; Subject Term: COMPUTER software; Subject Term: COMPUTER files; Subject Term: X-rays; Subject Term: ELECTROPHORESIS; Subject Term: TRANSFER RNA; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GRAFSTROM, ROLAND C.
AU - FORNACE JR., ALBERT J.
AU - AUTRUP, HERMAN
AU - LECHNER, JOHN F.
AU - HARRIS, CURTIS C.
T1 - Formaldehyde Damage to DNA and Inhibition of DNA Repair in Human Bronchial Cells.
JO - Science
JF - Science
Y1 - 1983/04/08/
VL - 220
IS - 4593
M3 - Article
SP - 216
EP - 218
SN - 00368075
AB - Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused theformation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713030; GRAFSTROM, ROLAND C. 1; FORNACE JR., ALBERT J. 1; AUTRUP, HERMAN 1; LECHNER, JOHN F. 1; HARRIS, CURTIS C. 1; Affiliations: 1: Laboratory of Human Carcinogenesis, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 4/ 8/1983, Vol. 220 Issue 4593, p216; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HASPEL, MARTIN V.
AU - ONODERA, T AKASHI
AU - PRABHAKAR, BELLUR S.
AU - HORITA, MASAKAZU
AU - SUZUKI, HOSHIBUMI
AU - NOTKINS, ABNER LOUIS
T1 - Virus-Induced Autoimmunity: Monoclonal Antibodies That React with Endocrine Tissues.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 304
EP - 306
SN - 00368075
AB - Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibodyproducing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-sp-ecific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas others recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713066; HASPEL, MARTIN V. 1; ONODERA, T AKASHI 1; PRABHAKAR, BELLUR S. 1; HORITA, MASAKAZU 1; SUZUKI, HOSHIBUMI 1; NOTKINS, ABNER LOUIS 1; Affiliations: 1: Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p304; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RICE, KENNER C.
AU - JACOBSON, ARTHUR E.
AU - BURKE JR., TERRENCE R.
AU - BAJWA, BALBIR S.
AU - STREATY, RICHARD A.
AU - KLEE, WERNER A.
T1 - Irreversible Ligands with High Selectivity Toward 8 or FL Opiate Receptors.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 314
EP - 316
SN - 00368075
AB - Alkylating agents that display strong selectivityfor opiate receptor types 8 or, u were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713071; RICE, KENNER C. 1; JACOBSON, ARTHUR E. 1; BURKE JR., TERRENCE R. 1; BAJWA, BALBIR S. 1; STREATY, RICHARD A. 2; KLEE, WERNER A. 2; Affiliations: 1: Laboratory of Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; 2: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p314; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOSLER, EDWARD M.
AU - COLEMAN, JAMES L.
AU - BENACH, JORGE L.
AU - MASSEY, DARLENE A.
AU - HANRAHAN, JOHN P.
AU - BURGDORFER, WILLY
AU - BARBOUR, ALAN G.
T1 - Natural Distribution of the Ixodes dammini Spirochete.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 321
EP - 322
SN - 00368075
AB - Spirochetes believed to be the cause of Lyme disease were isolatedfrom white-footed mice and white-tailed deer, the preferred natural hosts of Ixodes dammini, the tick vector. Evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. Some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713075; BOSLER, EDWARD M. 1; COLEMAN, JAMES L. 1; BENACH, JORGE L. 1; MASSEY, DARLENE A. 1; HANRAHAN, JOHN P. 2; BURGDORFER, WILLY 3; BARBOUR, ALAN G. 4; Affiliations: 1: New York State Department of Health, Health Science Center, State University of New York, Stony Brook 11794; 2: Field Service Division, Centers for Disease Control, Atlanta, Georgia 30333; 3: Epidemiology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840; 4: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p321; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOWARD, DENNIS F.
AU - BLUM, MURRAY S.
AU - FALES, HENRY M.
T1 - Defense in Thrips: Forbidding Fruitiness of a Lactone.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 335
EP - 336
SN - 00368075
AB - Expulsion of analfluidfrom the upturned abdomen was demonstrated to serve a defensive function in the thrips Bagnalliella yuccae. An allomone in the anal exudate was identified as -y-decalactone, a fruity-smelling compound that repelled potential predators. Chemical defenses may contribute to the ability of thrips to maintain large aggregations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713082; HOWARD, DENNIS F. 1; BLUM, MURRAY S. 1; FALES, HENRY M. 2; Affiliations: 1: Department of Entomology, University of Georgia, Athens 30602; 2: Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p335; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MUSCHEL, RUTH J.
AU - KHOURY, GEORGE
AU - LEBOWITZ, PAUL
AU - KOLLER, RICHARD
AU - DHAR, RAVI
T1 - Retraction of Data on the Human c-raslH Oncogene.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 336
EP - 336
SN - 00368075
N1 - Accession Number: 84713083; MUSCHEL, RUTH J. 1; KHOURY, GEORGE 1; LEBOWITZ, PAUL 2; KOLLER, RICHARD; DHAR, RAVI 3; Affiliations: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Medicine, Yale University Medical School, New Haven, Connecticut 06510; 3: Laboratory of Molecular Virology; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p336; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parker, Douglas A.
AU - Parker, Elizabeth S.
AU - Brody, Jacob A.
AU - Schoenberg, Ronald
T1 - Alcohol Use and Cognitive Loss among Employed Men and Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/05//
VL - 73
IS - 5
M3 - Article
SP - 521
EP - 526
PB - American Public Health Association
SN - 00900036
AB - A representative sample of 1,367 employed men and women in Detroit responded to questions about their drinking practices and then completed a cognitive test which measures abstraction abilities. Abstraction, tested while respondents were sober, decreased significantly as reported quantity of alcohol usually consumed per drinking occasion increased. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRINKING of alcoholic beverages
KW - DRINKING behavior
KW - GASTRONOMY
KW - ALCOHOLISM
KW - BINGE drinking
KW - SUBSTANCE abuse
KW - ALCOHOLIC beverages
KW - ALCOHOL
KW - DETROIT (Mich.)
N1 - Accession Number: 4945876; Parker, Douglas A. 1 Parker, Elizabeth S. 2 Brody, Jacob A. 3 Schoenberg, Ronald 4; Affiliation: 1: Professor of Human Development and Sociology, California State University, Long Beach, Long Beach, CA 90840, Bethesda, MD 2: Research Psychologist with the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 3: Associate Director, Epidemiology, Demography and Biometry Program, National institute on Aging, Bethesda, MD 4: Research Sociologist with the Laboratory of Socio-Environmental Studies, National Institute of Mental Health, Bethesda, MD; Source Info: May83, Vol. 73 Issue 5, p521; Subject Term: DRINKING of alcoholic beverages; Subject Term: DRINKING behavior; Subject Term: GASTRONOMY; Subject Term: ALCOHOLISM; Subject Term: BINGE drinking; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOLIC beverages; Subject Term: ALCOHOL; Subject Term: DETROIT (Mich.); NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 312140 Distilleries; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauder, Daniel N.
AU - Katz, Stephen I.
T1 - Strain Variation in the Induction of Tolerance by Epicutaneous Application of Trinitrochlorobenzene.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/05//
VL - 80
IS - 5
M3 - Article
SP - 383
EP - 386
SN - 0022202X
AB - It has been postulated that a relationship exists between the density of epidermal Langerhans cells and the capacity of the epidermis to promote the induction of contact sensitization. This postulate was developed, in part, because (1) mouse tail epidermis contains fewer ATPase-positive (presumably Langerhans) cells than does abdominal epidermis, and (2) when tails of C57B1/ 6 mice were painted with dinitrofluorobeuzene (DNFB), the mice were less sensitive than those painted on the abdomen. In addition, tail-painted mice were shown to be tolerant to subsequent attempts at sensitization with DNFB. In this study we found that by painting the tails of mice with the hapten trinitrochlorobenzene (TNCB), sensitization was induced in certain mouse strains (BALB/c, A/J, and CBA -- haplotypes H-2d, H-2n, H-2k, respectively), but tolerance resulted from painting the tails of other strains (C5'7Bl/6, C57B1/1O, and AB.Y -- haplotype H-2b). The ability to become sensitive or tolerant is not related to Langerhans cell density as detected by ATPase staining. While the mechanism for this strain difference in the induction of tolerance is unknown, tolerance induced in C57B1/6 mice is mediated in part by the generation of suppressor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOLERATION
KW - LANGERHANS cells
KW - DENDRITIC cells
KW - EPIDERMIS
KW - MICE
KW - TAILS
N1 - Accession Number: 12551991; Sauder, Daniel N. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May83, Vol. 80 Issue 5, p383; Subject Term: TOLERATION; Subject Term: LANGERHANS cells; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS; Subject Term: MICE; Subject Term: TAILS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12551991
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breathnach, Stephen M.
AU - Fox, Patricia A.
AU - Neises, Gabrielle R.
AU - Stanley, John R.
AU - Katz, Stephen I.
T1 - A Unique Epithelial Basement Membrane Antigen Defined by a Monoclonal Antibody (KF-1).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/05//
VL - 80
IS - 5
M3 - Article
SP - 392
EP - 395
SN - 0022202X
AB - The basement membrane zone (BMZ) of human skin is a complex structure which contains several well-defined components including bullous pemphigoid antigen, laminin, type IV collagen, and proteoglycan. Characterization of additional basement membrane (BM) constituents has been limited by their relative inaccessibility, insolubility, and low tissue concentration. We have produced a murine monoclonal antibody that has enabled us to define a unique constituent of the BMZ of human stratified squamous epithelia. The monoclonal antibody (KF-1) was raised by standard techniques using suction blister-derived trypsinized human epidermal cells as the antigen. Indirect immunofluorescence and immunoperoxidase staining of human and rhesus monkey tissues with KF-1 produced linear BMZ staining of stratified squamous epithelia. Glandular and vascular BMs were not stained. Immunoelectron microscopic studies of normal human skin and esophagus showed specific binding of KF-1 to the lamina densa of the BMZ, a localization identical to that of type LV collagen. However, unlike type IV collagen, which is not species specific and is found in all BMs, the antigen defined by KF-1 is collagenase-resistant and is specific for primate stratified squamous epithelia. These findings confirm the existence of regional variation in BM composition, and demonstrate for the first time that the lamina densa of stratified squamous epithelial BMs contains a constituent other than type IV collagen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIUM
KW - TISSUES
KW - ANTIGENS
KW - IMMUNITY
KW - MONOCLONAL antibody probes
KW - MONOCLONAL antibodies
N1 - Accession Number: 12553200; Breathnach, Stephen M. 1,2,3 Fox, Patricia A. 3 Neises, Gabrielle R. 3 Stanley, John R. 4 Katz, Stephen I. 3; Affiliation: 1: Visiting Associate, National Cancer Institute. 2: Dowling Fellow of British Association of Dermatologists. 3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 4: Dermatology Department, Uniformed Services University of Health Sciences, Bethesda, Maryland, U.S.A.; Source Info: May83, Vol. 80 Issue 5, p392; Subject Term: EPITHELIUM; Subject Term: TISSUES; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Subject Term: MONOCLONAL antibody probes; Subject Term: MONOCLONAL antibodies; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12553200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pato, Mary D.
AU - Adelstein, Robert S.
AU - Crouch, Deborah
AU - Safer, Brian
AU - Ingebretsen, Thomas S.
AU - Cohen, Philip
T1 - The Protein Phosphatases Involved in Cellular Regulation.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/05/02/
VL - 132
IS - 2
M3 - Article
SP - 283
EP - 287
PB - Wiley-Blackwell
SN - 00142956
AB - Two homogeneous protein phosphatases, termed 'smooth muscle phosphatase-!' and `smooth muscle phosphatase-Il'. isolated from turkey gizzard as enzymes active against the 20-kDa light chain of smooth muscle myosin, and a third homogeneous protein phosphatase from rabbit reticulocytes. purified as an enzyme active against protein synthesis initiation factor eIF-2, were classified using the criteria defined by Ingebritsen and Cohen [Eur. J. Biochem. (1983) 132. 255- 261]. All three enzymes were type-2 protein phosphatases based on their specificity for the α-subunit of phosphorylase kinase and insensitivity to inhibitor-i and inhibitor-2. The substrate specificities of smooth muscle phosphatase-I and the eIF-2 phosphatase were similar to the catalytic subunit of protein phosphatase-2A. Smooth muscle phosphatase-I could be designated as protein phosphatase-2A1 and eIF-2 phosphatase as protein phosphatase-2A2 on the basis of their subunit compositions. The substrate specificity. dependence of activity on Mg2 + and subunit composition of smooth muscle phosphatase-II allowed its assignment as protein phosphatase-2C. [ABSTRACT FROM AUTHOR]
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KW - SMOOTH muscle
KW - PROTEINS
KW - ERYTHROCYTES
KW - PROTEIN synthesis
KW - PHOSPHORYLATION
KW - BLOOD cells
N1 - Accession Number: 15817166; Pato, Mary D. 1,2 Adelstein, Robert S. 1,2 Crouch, Deborah 1,2 Safer, Brian 1,2 Ingebretsen, Thomas S. 1,2 Cohen, Philip 1,2; Affiliation: 1: Laboratories of Molecular Cardiology and Molecular Hematology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda MD. 2: Department of Biochemistry. University of Dundee.; Source Info: 5/2/83, Vol. 132 Issue 2, p283; Subject Term: SMOOTH muscle; Subject Term: PROTEINS; Subject Term: ERYTHROCYTES; Subject Term: PROTEIN synthesis; Subject Term: PHOSPHORYLATION; Subject Term: BLOOD cells; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DICK, STEVEN J.
AU - MACCHI, BEATRICE
AU - PAPAZOGLOU, SAVVAS
AU - OLDFIELD, EDWARD H.
AU - KORNBLITH, PAUL L.
AU - SMITH, BARRY H.
AU - GATELY, MAURICE K.
T1 - Lymphoid Cell-Glioma Cell Interaction Enhances Cell Coat Production by Human Gliomas: Novel Suppressor Mechanism.
JO - Science
JF - Science
Y1 - 1983/05/13/
VL - 220
IS - 4598
M3 - Article
SP - 739
EP - 742
SN - 00368075
AB - Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713259; DICK, STEVEN J. 1; MACCHI, BEATRICE 1; PAPAZOGLOU, SAVVAS 1; OLDFIELD, EDWARD H. 1; KORNBLITH, PAUL L. 1; SMITH, BARRY H. 1; GATELY, MAURICE K. 1; Affiliations: 1: Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 5/13/1983, Vol. 220 Issue 4598, p739; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mushinski, J. Frederic
AU - Potter, Michael
AU - Bauer, Steven R.
AU - Reddy, E. Premkumar
T1 - DNA Rearrangement and Altered RNA Expression of the c-myb Oncogene in Mouse Plasmacytoid Lymphosarcomas.
JO - Science
JF - Science
Y1 - 1983/05/20/
VL - 220
IS - 4599
M3 - Article
SP - 795
EP - 798
SN - 00368075
AB - Three types of tumors termed plasmacytomas (ABPC's), lymphosarcomas (ABLS's), and plasmacytoid lymphosarcomas (ABPL's) arise in BALBIc mice treated with pristane and Abelson murine leukemia virus (A-MuLV). While most ABPC's and ABLS's contain integrated A-MuLVproviral genome and synthesize the v-abl RNA, most ABPL's do not. The ABPL tumors were examined for the expression of other oncogenes that may be associated with their transformed state, in the absence of transforming virus. These tumors expressed abundant c-myb RNA of unusually large size and showed DNA rearrangements of the c-myb locus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713269; Mushinski, J. Frederic 1; Potter, Michael 1; Bauer, Steven R. 2; Reddy, E. Premkumar 3; Affiliations: 1: Staff members, Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20205; 2: Graduate student, Department of Biochemistry, University of Maryland, College Park 20742; 3: Staff member, Laboratory of Cellular and Molecular Biology, Bethesda, Maryland 20205; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p795; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GAINER, HAROLD
T1 - Vasopressin: An Experimental Model.
JO - Science
JF - Science
Y1 - 1983/05/20/
VL - 220
IS - 4599
M3 - Article
SP - 856
EP - 856
SN - 00368075
N1 - Accession Number: 84713314; GAINER, HAROLD 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p856; Number of Pages: 8/9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GELMANN, EDWARD P.
AU - POPOVIC, MIKULAS
AU - BLAYNEY, DOUGLAS
AU - MASUR, HENRY
AU - SIDHU, GURDIP
AU - STAHL, ROSALYN E.
AU - GALLO, ROBERT C.
T1 - Proviral DNA of a Retrovirus, Human T-Cell Leukemia Virus, in Two Patients with AIDS.
JO - Science
JF - Science
Y1 - 1983/05/20/
VL - 220
IS - 4599
M3 - Article
SP - 862
EP - 865
SN - 00368075
AB - The acquired immune deficiency syndrome (AIDS) is characterized by Tlymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLY-) is associated with Tcell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis ofDNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713319; GELMANN, EDWARD P. 1; POPOVIC, MIKULAS 1; BLAYNEY, DOUGLAS 2; MASUR, HENRY 3; SIDHU, GURDIP 4; STAHL, ROSALYN E. 5; GALLO, ROBERT C. 6; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Epidemiology Branch, National Cancer Institute; 3: Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20205; 4: Department of Pathology, New York University Medical Center, New York 10010; 5: Department of Pathology, New York Veterans Administration Hospital, New York 10010; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p862; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GALLO, ROBERT C.
AU - SARIN, PREM S.
AU - GELMANN, E. P.
AU - ROBERT-GUROFF, MARJORIE
AU - RICHARDSON, ERSELL
AU - KALYANARAMAN, V. S.
AU - MANN, DEAN
AU - SIDHU, GURDIP D.
AU - STAHL, ROSALYN E.
AU - ZOLLA-PAZNER, SUSAN
AU - LEIBOWITCH, JACQUE
AU - POPOVIC, MIKULAS
T1 - Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS).
JO - Science
JF - Science
Y1 - 1983/05/20/
VL - 220
IS - 4599
M3 - Article
SP - 866
EP - 868
SN - 00368075
AB - Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epidemic T-cell immune deficiency disorder known as AIDS. Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713320; GALLO, ROBERT C. 1; SARIN, PREM S. 1; GELMANN, E. P. 1; ROBERT-GUROFF, MARJORIE 1; RICHARDSON, ERSELL 1; KALYANARAMAN, V. S. 2; MANN, DEAN 3; SIDHU, GURDIP D. 4; STAHL, ROSALYN E. 4; ZOLLA-PAZNER, SUSAN 4; LEIBOWITCH, JACQUE 5; POPOVIC, MIKULAS 6; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; 2: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland; 3: Laboratory of Human Carcinogenesis, National Cancer Institute; 4: Department of Pathology, New York Veterans Administration Hospital, New York 10010; 5: Department of Immunologie, Hôpital Raymond Poincaré, 92380 Garches, France; 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Issue Info: 5/20/1983, Vol. 220 Issue 4599, p866; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - EVA, ALESSANDRA
AU - AARONSON, STUART A.
T1 - Frequent Activation of c-kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene.
JO - Science
JF - Science
Y1 - 1983/05/27/
VL - 220
IS - 4600
M3 - Article
SP - 955
EP - 956
SN - 00368075
AB - The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713351; EVA, ALESSANDRA 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p955; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VAN KAMMEN, DANIEL P.
AU - MANN, LEE S.
AU - STERNBERG, DAVID E.
AU - SCHEININ, MIKA
AU - NINAN, PHILIP T.
AU - MARDER, STEPHEN R.
AU - VAN KAMMEN, WELMOET B.
AU - RIEDER, RONALD O.
AU - LINNOILA, MARKKU
T1 - Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy.
JO - Science
JF - Science
Y1 - 1983/05/27/
VL - 220
IS - 4600
M3 - Article
SP - 974
EP - 977
SN - 00368075
AB - Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713360; VAN KAMMEN, DANIEL P. 1; MANN, LEE S. 2; STERNBERG, DAVID E. 3; SCHEININ, MIKA 4; NINAN, PHILIP T. 5; MARDER, STEPHEN R. 6; VAN KAMMEN, WELMOET B. 7; RIEDER, RONALD O. 8; LINNOILA, MARKKU 4; Affiliations: 1: Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; 2: Laboratory of Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Yale University Medical School and Connecticut Mental Health Center, New Haven, Connecticut 06508; 4: Clinical Psychobiology Branch, National Institute of Mental Health; 5: Biological Psychiatry Branch, National Institute of Mental Health; 6: University of California and Brentwood Veterans Administration, Los Angeles 90093; 7: Western Psychiatric Institute and Clinic; 8: New York State Psychiatric Institute and Columbia University, New York 10032; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p974; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MUNSON, P. J.
AU - RODBARD, D.
T1 - Number of Receptor Sites from Scatchard and Klotz Graphs: A Constructive Critique.
JO - Science
JF - Science
Y1 - 1983/05/27/
VL - 220
IS - 4600
M3 - Article
SP - 979
EP - 981
SN - 00368075
N1 - Accession Number: 84713362; MUNSON, P. J. 1; RODBARD, D. 1; Affiliations: 1: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 5/27/1983, Vol. 220 Issue 4600, p979; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moment, Gairdner
T1 - DIET, NUTRITION, AND CANCER.
JO - BioScience
JF - BioScience
Y1 - 1983/06//
VL - 33
IS - 6
M3 - Book Review
SP - 398
EP - 398
SN - 00063568
AB - The article reviews the book "Diet, Nutrition, and Cancer," by the Committee on Diet, Nutrition and Cancer.
KW - Diet in disease
KW - Cancer
KW - Nonfiction
KW - Diet, Nutrition & Cancer (Book)
N1 - Accession Number: 28051695; Moment, Gairdner 1; Affiliations: 1 : Guest Scientist, National Institute on Aging, Professor Emeritus, Biology, Coucher College, Baltimore, MD 21204; Source Info: Jun1983, Vol. 33 Issue 6, p398; Subject Term: Diet in disease; Subject Term: Cancer; Subject Term: Nonfiction; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 691
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Kilhoffer, Marie-Claude
AU - Cook, G. Hope
AU - Wolff, J.
T1 - Calcium-Independent Activation of Adenylate Cyclase by Calmodulin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/06//6/1/83
VL - 133
IS - 1
M3 - Article
SP - 11
EP - 15
PB - Wiley-Blackwell
SN - 00142956
AB - Adenylate cyclase of Bordetella pertussis is stimulated by calmodulin by two distinct interactions. At low activator concentrations (≈1 nM) the process is Ca2+-dependent (i.e. inhibited by EGTA added before calmodulin). High activator concentrations (≈ 0.1-10 µM) stimulate adenylate cyclase also in the presence of EGTA, an effect not accounted for by residual Ca2+ or low concentrations of Ca · calmodulin, which thus appears to be due to calcium-free calmodulin. Some calmodulin dose-response curves show both phases of stimulation, separated by a plateau of activity, and half-maximal activating concentrations differ by 100-300-fold. Both effects are on the V and not the Km for ATP and are not mimicked by 105-fold greater concentrations of parvalbumin or by various polyanions. In addition, adenylate cyclase stimulation at high calmodulin concentrations is greater in the presence of EGTA than in its absence. This enhancement is also produced by 1,10-phenathroline and 8-hydroxyquinoline but not by non-chelating isomers. These compounds are poor Ca2+ chelators, stimulate at any calmodulin concentration (unlike EGTA), and suggest regulation of this adenylate cyclase by a second metal ion. [ABSTRACT FROM AUTHOR]
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KW - ADENYLATE cyclase
KW - CALMODULIN
KW - BORDETELLA pertussis
KW - CALCIUM
KW - METAL ions
KW - ACTIVATION (Chemistry)
N1 - Accession Number: 13757570; Kilhoffer, Marie-Claude 1 Cook, G. Hope 1 Wolff, J. 1; Affiliation: 1: National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Maryland; Source Info: 6/1/83, Vol. 133 Issue 1, p11; Subject Term: ADENYLATE cyclase; Subject Term: CALMODULIN; Subject Term: BORDETELLA pertussis; Subject Term: CALCIUM; Subject Term: METAL ions; Subject Term: ACTIVATION (Chemistry); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Hall, Russell P.
AU - Peck, Gary L.
AU - Lawley, Thomas J.
T1 - Circulating IgA Complexes in Patients with Psoriasis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/06//
VL - 80
IS - 6
M3 - Report
SP - 465
EP - 467
SN - 0022202X
AB - The sera of 21 patients with psoriasis were examined for the presence of IgA-containing circulating immune complexes (CIC) using the Raji IgA radioimmunoassay. In addition, the Raji IgG radioimmunoassay and 125I-Clq binding assay were used to detect IgG- and IgM-containing CIC. Twenty five patients with other hyperkeratotic skin disorders were studied as controls. Patients were studied before institution of systemic therapy with etretinate (20 patients) or 13-cis-retinoic acid (1 patient). In addition, sera of 15 of the patients treated with etretinate were studied before, during, and after therapy. The extent of pretreatment disease involvement as well as response to therapy were evaluated in a blinded fashion. Fourteen of 21 (67%) patients with psoriasis had evidence of IgA-containing CIC at some time during the course of their disease, as compared to only 1 of 25 patients with other hyperkeratotic skin disorders. In contrast, only 2 of 19 (11%) had evidence of IgG-containing CIC using the Raji IgG assay, and only 1 of 19 (5%) had evidence of IgG- or IgM-containing CIC using the 125I-Clq binding assay positive correlation was found between the extent of pretreatment disease involvement and the level of IgA-containing CIC by linear regression analysis (p = 0.01). There was, however, no correlation between clinical improvement and the presence or level of IgA-containing CIC in 15 patients followed during therapy. Sucrose density gradient analysis of the IgA-containing CIC found in 2 of these patient demonstrated IgA-containing CIC in the 9S to 13S region. The finding of IgA-containing CIC in a significant number of patients with psoriasis and the relative absence of IgG- or IgM-containing CIC suggest that IgA containing CIC may play a role in psoriasis. The lack of correlation with clinical improvement, however, suggests these IgA-containing CIC are not directly related to the cutaneous manifestations of psoriasis, but may be important in the modulation of immune or inflammatory responses in these patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSORIASIS
KW - SKIN diseases
KW - RADIOIMMUNOASSAY
KW - ETRETINATE
KW - THERAPEUTICS
KW - REGRESSION analysis
N1 - Accession Number: 12534883; Hall, Russell P. 1 Peck, Gary L. 1 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p465; Subject Term: PSORIASIS; Subject Term: SKIN diseases; Subject Term: RADIOIMMUNOASSAY; Subject Term: ETRETINATE; Subject Term: THERAPEUTICS; Subject Term: REGRESSION analysis; Number of Pages: 3p; Document Type: Report
L3 - 10.1111/1523-1747.ep12534883
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yancey, Kim B.
AU - Cason, Joseph C.
AU - Hall, Russell P.
AU - Lawley, Thomas J.
T1 - Dietary Gluten Challenge Does Not Influence the Levels of Circulating Immune Complexes in Patients with Dermatitis Herpetiformis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/06//
VL - 80
IS - 6
M3 - Article
SP - 468
EP - 471
SN - 0022202X
AB - To examine the relationship between the gluten-sensitive enteropathy (GSE) and IgA circulating immune complexes (CIC) in dermatitis herpetiformis (DH) a series of dietary gluten-challenge studies were performed in patients with DH and patients with ordinary GSE. Serial serum samples were monitored for IgA-, IgG-, and IgM-containing CIC levels. In the first study, 9 DH patients and 5 controls were fed 20 g of gluten flour as a breakfast meal on 1 of 2 consecutive study days. DH patients did not develop or increase their levels of CIC after gluten-challenge or gluten-free meals. There was no significant difference between the DH patients and the control group in regard to development of CIC. To evaluate the effect of dietary gluten in another form, 8 DH patients were given meals containing 100 g of boiled Canadian cracked wheat. Two patients with ordinary GSE were also challenged with cracked wheat, Again there was no elevation or induction of CIC above baseline determinations by gluten-challenge meals, These studies suggest that dietary gluten does not induce the formation of CIC in patients with DH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATITIS herpetiformis
KW - GLUTEN
KW - INTESTINAL diseases
KW - DIET
KW - SERUM
KW - MEAL
N1 - Accession Number: 12534895; Yancey, Kim B. 1 Cason, Joseph C. 1 Hall, Russell P. 1 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p468; Subject Term: DERMATITIS herpetiformis; Subject Term: GLUTEN; Subject Term: INTESTINAL diseases; Subject Term: DIET; Subject Term: SERUM; Subject Term: MEAL; NAICS/Industry Codes: 311212 Rice Milling; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12534895
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauder, Daniel N.
AU - Noonan, Frances P.
AU - DeFabo, Edward C.
AU - Katz, Stephen I.
T1 - Ultraviolet Radiation Inhibits Alloantigen Presentation by Epidermal Cells: Partial Reversal by the Soluble Epidermal Cell Product, Epidermal Cell-Derived Thymocyte-Activating Factor (ETAF).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/06//
VL - 80
IS - 6
M3 - Article
SP - 485
EP - 489
SN - 0022202X
AB - It has been postulated that ultraviolet radiation (UVR) alters antigens presentation by macrophages. This is thought to be due, in part, to inhibition of macrophage-derived interleukin 1 (IL-1), which is a hormone-like factor with immunoregulatory functions. Conventional stimulator cells for antigen presentation are macrophages; however, other cell types such as epidermal Langerhans cells are capable of antigen presentation. Keratinocytes also play a role in the immune system by providing a factor with IL-1-like activity, termed E dermal cell-derived Thymocyte-Activating Factor (ETAF).The purpose of this study was to determine whether UVR affects alloantigen presentation by epidermal cells and if so, whether the UV-induced change is due to UVR alteration in ETAF activity. Epidermal cells from UV-treated BALB/c mice (UV-EC) or from non-UV-treated mice (EC) were x-irradiated and then cocultured for 5 days with allogeneic T-cells from C57B1/6 mice. UV EC caused less T-cell stimulation than did EC from non-UV-treated animals. When chromatography purified fractions of ETAF were added to cultured UV-EC, partial restoration of T-cell stimulation was seen. These results suggest that this UV-induced defect in alloantigen presentation is due, in part, to decreased ETAF activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - MACROPHAGES
KW - ULTRAVIOLET radiation
KW - INTERLEUKIN-1
KW - LANGERHANS cells
KW - T cells
N1 - Accession Number: 12534951; Sauder, Daniel N. 1 Noonan, Frances P. 2 DeFabo, Edward C. 2 Katz, Stephen I. 1; Affiliation: 1: Dermatology branch, National Cancer Institute, National institute of Health, Bethesda, Maryland, U.S.A.. 2: N.C.I. Frederick Cancer Research Facility, Frederick, Maryland, U.S.A..; Source Info: Jun83, Vol. 80 Issue 6, p485; Subject Term: ANTIGENS; Subject Term: MACROPHAGES; Subject Term: ULTRAVIOLET radiation; Subject Term: INTERLEUKIN-1; Subject Term: LANGERHANS cells; Subject Term: T cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12534951
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12534951&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gail, Mitchell H.
T1 - Comment.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1983/06//
VL - 78
IS - 382
M3 - Article
SP - 275
SN - 01621459
AB - The article comments on the paper by Murray Aitkin, Nan Laird and Brian Francis which presents an analyses of survival of patients in the Stanford Heart Transplantation Program, published in the June 1983 issue of the "Journal of the American Statistical Association." The author wishes to congratulate Aitkin, Laird and Francis and to elaborate on some of their cautionary remarks, such as "the apparent benefit of transplant is dwarfed by the magnitude of our uncertainty." The author shall discuss the weakness of the evidence, and he shall use the authors' models to highlight this weakness. An ideal experiment to determine whether transplantation is beneficial would be to regard a patient as eligible for study at the time a suitably matched heart became available and then to randomly allocate that patient either to transplantation or to conservative management. A valid comparison of postrandomization survival could be made, even without covariate adjustment. However, regression methods or stratified analyses could be used to adjust for treatment imbalances on known covariates, such as waiting time since entry into the program. Unfortunately, the present data are not protected by randomization. A surgeon might choose to give the heart to that one of a pair of potential recipients who had waited longer. But waiting time is a dominant covariate: the longer you wait, the better is your prognosis on conservative management.
KW - REGRESSION analysis
KW - ANALYSIS of covariance
KW - MATHEMATICAL models
KW - HOSPITAL costs
KW - HEART transplantation
KW - MEDICAL care costs
KW - UNCERTAINTY
KW - CARDIAC surgery -- Patients
KW - FRANCIS, Brian
KW - JOURNAL of the American Statistical Association (Periodical)
N1 - Accession Number: 4607615; Gail, Mitchell H. 1; Affiliations: 1: Medical Statistical Investigator, Biometry Branch, National Cancer Institute, Bethesda, MD 20205.; Issue Info: Jun83, Vol. 78 Issue 382, p275; Thesaurus Term: REGRESSION analysis; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: HOSPITAL costs; Subject Term: HEART transplantation; Subject Term: MEDICAL care costs; Subject Term: UNCERTAINTY; Subject Term: CARDIAC surgery -- Patients; Reviews & Products: JOURNAL of the American Statistical Association (Periodical); People: FRANCIS, Brian; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wei, L. J.
AU - Gail, M. H.
T1 - Nonparametric Estimation for a Scale-Change With Censored Observations.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1983/06//
VL - 78
IS - 382
M3 - Article
SP - 382
SN - 01621459
AB - Nonparametric point and interval estimators of the ratio of two scale parameters are given for arbitrarily right-censored data based on the idea of Hodges and Lehmann (1963). These estimators are defined in terms of rank test statistics for testing the equality of two survival distributions. The asymptotic properties and efficiencies of estimators corresponding to the tests studied by Gill (1980) are investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - NONPARAMETRIC statistics
KW - MATHEMATICAL statistics
KW - STATISTICAL hypothesis testing
KW - STOCHASTIC processes
KW - DISTRIBUTION (Probability theory)
KW - PROBABILITY theory
KW - INTERVAL analysis (Mathematics)
KW - LEAST squares
KW - ASYMPTOTIC theory
KW - Accelerated failure time model
KW - Arbitrarily right-censored observations
KW - Asymptotic relative efficiency
KW - Gehan-Gilbert test
KW - Logrank test.
N1 - Accession Number: 4607779; Wei, L. J. 1; Gail, M. H. 2; Affiliations: 1: Professor, Department of Statistics, George Washington University, Washington, D.C. 20052.; 2: Medical Statistical Investigator, Clinical and Diagnostic Trials Section, Biometry Branch, National Cancer Institute, Bethesda, MD 20205.; Issue Info: Jun83, Vol. 78 Issue 382, p382; Thesaurus Term: ESTIMATION theory; Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: STOCHASTIC processes; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: INTERVAL analysis (Mathematics); Subject Term: LEAST squares; Subject Term: ASYMPTOTIC theory; Author-Supplied Keyword: Accelerated failure time model; Author-Supplied Keyword: Arbitrarily right-censored observations; Author-Supplied Keyword: Asymptotic relative efficiency; Author-Supplied Keyword: Gehan-Gilbert test; Author-Supplied Keyword: Logrank test.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hoar, Sheila
T1 - Job Exposure Matrix Methodology.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 9
EP - 26
SN - 07313810
N1 - Accession Number: 79032216; Hoar, Sheila 1; Affiliations: 1: Environmental Epidemiology Branch Division of Cancer, Cause and Prevention National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 1983, Vol. 21 Issue 1/2, p9; Number of Pages: 18p; Document Type: Article
L3 - 10.3109/15563658308990408
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zlegler, Regina G.
T1 - Assessing Diet in Case-Control Studies of Cancer.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 129
EP - 150
SN - 07313810
N1 - Accession Number: 79032215; Zlegler, Regina G. 1; Affiliations: 1: Environmental Epidemiology Branch Division of Cancer, Cause and Prevention National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 1983, Vol. 21 Issue 1/2, p129; Number of Pages: 22p; Document Type: Article
L3 - 10.3109/15563658308990413
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06526-027
AN - 2006-06526-027
AU - Zahn-Waxler, Carolyn
T1 - Changing Views of Childhood.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1983/06//
VL - 28
IS - 6
SP - 455
EP - 456
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06526-027. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn-Waxler, Carolyn; Laboratory of Developmental Psychology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Childhood Development; Language; Motor Development; Psychosocial Development; Social Skills. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Moore, Shirley G. (Ed); Cooper, Catherine R. (Ed). The Young Child: Reviews of Research, Vol. 3=Washington, D.C.: National Association for the Education of Young Children, 1982. 723 pp. $7.15; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Jun, 1983.
AB - Reviews the book, The Young Child: Reviews of Research, Vol. 3 edited by Shirley G. Moore and Catherine R. Cooper (1982). This book provides a comprehensive summary and integration of research in several areas of young children's socialemotional, cognitive, and physical development Children's social-emotional beginnings--including factors related to thriving, biological aspects of early parent-child interaction, and child rearing during the preschool years--constitute the first topics. Language and thought are cogently discussed in the context of social perspective-taking and egocentrism, concept development, and how adults talk to young children Social development is considered in terms of peer relationships and social skills, the facilitation of altruism, and deleterious effects of labeling 'minority' children. Biological malleability is addressed in relation to sex differences and motor development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - young children
KW - social development
KW - child interaction
KW - social skills
KW - concept development
KW - motor development
KW - 1983
KW - Childhood Development
KW - Language
KW - Motor Development
KW - Psychosocial Development
KW - Social Skills
KW - 1983
U2 - Moore, Shirley G. (Ed); Cooper, Catherine R. (Ed). (1982); The Young Child: Reviews of Research, Vol. 3; Washington, D.C.: National Association for the Education of Young Children, 1982. 723 pp. $7.15
DO - 10.1037/022101
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - REDDY, E. PREMKUMAR
T1 - Nucleotide Sequence Analysis of the T24 Human Bladder Carcinoma Ontogene.
JO - Science
JF - Science
Y1 - 1983/06/03/
VL - 220
IS - 4601
M3 - Article
SP - 1061
EP - 1063
SN - 00368075
AB - The nucleotide sequence of the 124 human bladder carcinoma oncogene was determined, and the coding and noncoding sequences of the genome were identified. The amino acid sequence of p21, the translational product of the 724 oncogene, was predicted from the nucleotide sequence of the oncogene. Comparison of this sequence with that of the normai cellular homolog showed that a single point mutation in the coding sequences of the 124 oncogene resulted in the acquisition of transforming properties. Other differences betveen the 724 oncogene hnd its normal cellular homolog were found in the 5' noncoding and 3' noncoding sequences, but these differences appear to be due to polymorphism and do not play a significant role in the transformation process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713400; REDDY, E. PREMKUMAR 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 6/ 3/1983, Vol. 220 Issue 4601, p1061; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DOCAMPO, ROBERTO
AU - MORENO, SILVIA N. J.
AU - MUNIZ, RAMIRO P. A.
AU - CRUZ, FERNANDO S.
AU - MASON, RONALD P.
T1 - Light-Enhanced Free Radical Formation and Trypanocidal Action of Gentian Violet (Crystal Violet).
JO - Science
JF - Science
Y1 - 1983/06/17/
VL - 220
IS - 4603
M3 - Article
SP - 1292
EP - 1295
SN - 00368075
AB - Transmission of Chagas' disease by transfusion of blood containing Trypanosoma cruzi has often been reported, and gentian violet, a triarylmethane dye, is widely used by blood banks in attempts to eliminate such transmission. In a study of intact trypanosomes, gentian violet was found to undergo a one-electron reduction to produce a carbon-centered free radical as demonstrated by electron spin resonance spectroscopy. Either reduced nicotinamide adenine dinucleotide or the reduced dinucleotide phosphate could serve as a source of reducing equivalents for the production of this free radical by homogenates of Trypanosoma cruzi. The formation of this free radical, and the trypanocidal action of gentian violet, were enhanced by light. The enhanced free radical formation may be the basic cause of the selective toxicity of gentian violet to Trypanosoma cruzi. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88000766; DOCAMPO, ROBERTO 1; MORENO, SILVIA N. J. 1; MUNIZ, RAMIRO P. A. 2; CRUZ, FERNANDO S. 2; MASON, RONALD P. 3; Affiliations: 1: Centro de Investigaciones Bioenergéticas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; 2: Centro Brasileiro de Pesquisas Fisicas and Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 3: Laboratory of Environmental Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 6/17/1983, Vol. 220 Issue 4603, p1292; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VINCENT, STEVEN R.
AU - HÖKFELT, THOMAS
AU - SKIRBOLL, LANA R.
AU - JANG-YEN WU
T1 - Hypothalamic γ-Aminobutyric Acid Neurons Project to the Neocortex.
JO - Science
JF - Science
Y1 - 1983/06/17/
VL - 220
IS - 4603
M3 - Article
SP - 1309
EP - 1311
SN - 00368075
AB - Three groups of γ-aminobutyric acid-containing neurons were found in the mammillary region of the posterior hypothalamus. The groups correspond to the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Many cells in these nuclei were retrogradely labeled with fast blue after the injection of this fluorescent dye into the neocortex. Immunohistochemical experiments showed that these same neurons also contained the γ-aminobutyric acid-synthesizing enzyme glutamate decarboxylase. These results provide morphological evidence for a γ-aminobutyric acid pathway arising in magnocellular neurons of the posterior hypothalamus and innervating the neocortex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88000773; VINCENT, STEVEN R. 1; HÖKFELT, THOMAS 1; SKIRBOLL, LANA R. 2; JANG-YEN WU 3; Affiliations: 1: Department of Histology, Karolinska Institute, S-104 01, Stockholm, Sweden; 2: Biological Phychiatry Brach, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030; Issue Info: 6/17/1983, Vol. 220 Issue 4603, p1309; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hitchcock, Penny J.
T1 - Aberrant Migration of Lipopolysaccharide in Sodium Dodecyl Sulfate/Polyacrylamide Gel Electrophoresis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/07//7/1/83
VL - 133
IS - 3
M3 - Article
SP - 685
EP - 688
PB - Wiley-Blackwell
SN - 00142956
AB - Purified lipopolysaccharides of salmonellae strains were separated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Pre-electrophoresis of polyacrylamide gels had no apparent effect on one-dimensional silver-stained lipopolysaccharide profiles. However, without pre-electrophoresis, two-dimensional and three-dimensional patterns contained numerous bands with varied migration patterns compared to those in the one-dimension gels. The lipopolysaccharide was altered within the polyacrylamide gel during electrophoresis. Pre-electrophoresis of gels eliminated a berrant migration patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA typhimurium
KW - ENDOTOXINS
KW - POLYACRYLAMIDE gel electrophoresis
KW - PHENOLS
KW - ENZYMES
KW - BIOCHEMISTRY
N1 - Accession Number: 13747377; Hitchcock, Penny J. 1; Affiliation: 1: Department of Health and Human Services, National Institute of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana; Source Info: 7/1/83, Vol. 133 Issue 3, p685; Subject Term: SALMONELLA typhimurium; Subject Term: ENDOTOXINS; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: PHENOLS; Subject Term: ENZYMES; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paia, S. Balakrishna
AU - Krishnabhargava, M.
AU - Vasantharajan, V.N.
T1 - Evaluation of carcinogenicity of fenaminosulf ( P ‐dimethylaminobenzenediazosodium sulfonate) and dimethyl‐P‐phenylenediamine in rats.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1983/07//
VL - 18
IS - 4
M3 - Article
SP - 503
EP - 517
SN - 03601226
AB - Carcinogenicity of the fungicide fenaminosulf (p‐dimethylami‐nobenzenediazosodium sulfonate) and one of its bacterial metabolite, dimethyl‐p‐phenylenediamine (DMPDA) was evaluated in rats. Over a 17 month period, rats fed with 250 mg of the compounds per kg of feed (in the presence or absence of nitrite) did not develop tumors. Phenols were detected in the urine and faeces of rats receiving either fenaminosulf or DMPDA suggesting possible detoxification of these compounds. These compounds being positive in mutagenicity screening tests in the bacteria, in the light of our present studies it is suggested that testing potential carcinogens in experimental animals is a pre‐requisite before arriving at definitive conclusions on the carcinogenicity of chemicals. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490545; Paia, S. Balakrishna 1,2 Krishnabhargava, M. 3 Vasantharajan, V.N. 1; Affiliation: 1: Microbiology and Cell Biology Laboratory, Indian Institute of Science, Bangalore, 560012, India 2: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, N.C., 27709, U.S.A. 3: Kidwai Memorial Cancer Institute, Bangalore, India; Source Info: Jul1983, Vol. 18 Issue 4, p503; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/10934528309375119
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06525-036
AN - 2006-06525-036
AU - Vietze, Peter M.
T1 - Preventing Infant Psychopathology.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1983/07//
VL - 28
IS - 7
SP - 549
EP - 550
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06525-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Vietze, Peter M.; Mental Retardation Research Centers Program, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Developmental Stages; Infant Development; Mental Health Programs; Program Development; Psychopathology. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Greenspan, Stanley I. Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention=New York: International Universities Press, 1981. 278 pp. $27.50; 1981. References Available: Y. Page Count: 2. Issue Publication Date: Jul, 1983.
AB - Reviews the book, Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention by Stanley I. Greenspan (1981). The present work fleshes out the brief overview provided in the earlier volume and provides case material to illustrate the six stages of development through which the infant passes. In the description of most stages, four factors are considered: child capacities, environmental characteristics, fears of the caretaker, and principles of prevention intervention and treatment. These are followed by case materials to illustrate various aspects of the stage with examples from the Clinical Infant Development Program of the Mental Health Study Center. This work represents a noteworthy integration of clinical practice, theoretical formulation, and systematic observation of infants and mothers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention intervention
KW - infant passes
KW - infant psychopathology
KW - infant development
KW - clinical diagnosis
KW - developmental stages
KW - 1983
KW - Developmental Stages
KW - Infant Development
KW - Mental Health Programs
KW - Program Development
KW - Psychopathology
KW - 1983
U2 - Greenspan, Stanley I. (1981); Psychopathology and Adaptation in Infancy and Early Childhood: Principles of Clinical Diagnosis and Preventive Intervention; New York: International Universities Press, 1981. 278 pp. $27.50
DO - 10.1037/022176
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - AQUADRO, CHARLES F.
T1 - Macromolecular Sequences in Systematics and Evolutionary Biology.
JO - Science
JF - Science
Y1 - 1983/07/08/
VL - 221
IS - 4606
M3 - Article
SP - 147
EP - 148
SN - 00368075
N1 - Accession Number: 84672880; AQUADRO, CHARLES F. 1; Affiliations: 1: Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: 7/ 8/1983, Vol. 221 Issue 4606, p147; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ikeda, Toshihiko
AU - Altieri, Mario
AU - Yuan-Tsong Chen
AU - Nakamura, Michitoshi
AU - Tukey, Robert H.
AU - Nebert, Daniel W.
AU - Negishi, Masahiko
T1 - Characterization of Cytochrome P2-450 (20-S) mRNA.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/07/15/
VL - 134
IS - 1
M3 - Article
SP - 13
EP - 18
PB - Wiley-Blackwell
SN - 00142956
AB - Mouse liver cytochrome P2-450 is defined as the major isosafrole-inducible form of P-450 which is most specific for isosafrole metabolism. λ.AhP-1 represents a 15.5 × 103-base-pair segment of mouse genomic DNA having the cytochrome P1-450 gene (≈4600 base pairs) located in the middle portion. Using various subclones as probes, we investigated the differential expression of P1-450 mRNA and P2-450 mRNA induction as a function of association with the Ah locus, 3-methylcholamhrene or isosafrole dosage, tissue specificity, and developmental age. Both P1-450 (23-S) mRNA and P2-450 (20-S) mRNA induction processes are regulated by the Ah receptor• P2-450 mRNA is about 10-fold more sensitive than P1-450 mRNA to induction by either 3-methylcholantbrene or isosafrole. Phenobarbital pretreatment has no effect at all on either P1-450 mRNA or P2-450 mRNA. Whereas both P1-450 mRNA and P2-450 mRNA are induced by 3-methylcholanthrcne in C57BL/6N liver, P1-450 (23-S) mRNA but not P2-450 (20-S) mRNA is induced by 3-methylcholanthrene in C57BL/6N kidney. P1-450 mRNA induction by 3-methyleholanthrene is measurable in C57BL/6N liver at day 15 of gestation, and the expression becomes enhanced with increasing age. P1-450 mRNA induction by 3-metbyleholanthrcne in C57BL/6N liver appears about 7 days later during development than 3-methylcholanthrene-inducible P1-450 mRNA. Both 3-methylcholanthrene-induced P1 450 mRNA and P2-450 mRNA are detectable in DBA/2N liver; their appearance is later in development, however, and at. lower concentrations than that seen with C57BL/6N liver. P1-450 (23-S) mRNA and P2-450 (20-S) mRNA appear to hybridize to a common 5′ fragment of the P1-450 gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - PROTEIN metabolism
KW - MESSENGER RNA
KW - CELL receptors
KW - MOLECULAR genetics
KW - BIOCHEMISTRY
N1 - Accession Number: 13832442; Ikeda, Toshihiko 1 Altieri, Mario 1 Yuan-Tsong Chen 1 Nakamura, Michitoshi 1 Tukey, Robert H. 1 Nebert, Daniel W. 1 Negishi, Masahiko 1; Affiliation: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/83, Vol. 134 Issue 1, p13; Subject Term: CYTOCHROME P-450; Subject Term: PROTEIN metabolism; Subject Term: MESSENGER RNA; Subject Term: CELL receptors; Subject Term: MOLECULAR genetics; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nakamura, Michitoshi
AU - Negishi, Masahiko
AU - Altieri, Mario
AU - Yuan-Tsong Chen
AU - Ikeda, Toshihiko
AU - Tukey, Robert H.
AU - Nebert, Daniel W.
T1 - Structure of the Mouse Cytochrome P1-450 Genomic Gene.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/07/15/
VL - 134
IS - 1
M3 - Article
SP - 19
EP - 25
PB - Wiley-Blackwell
SN - 00142956
AB - Clone 46 was previously shown to represent mouse cytochrome P1-450 cDNA by both translation arrest experiments and segregation of induced P1-450 mRNA with induced aryl hydrocarbon hydroxylase activity among individual 3-methylcholanthrene-treated offspring of the (C57BL/6N)(DBA/2N)F1 × DBA/2N backcross. With clone 46 as a probe, a MOPC 41 mouse genomic-DNA library was screened. λ3NT 12, a 16 × 103-base-pair insert of genomic DNA grown in a recombinant Charon 4A λ vector phage, was isolated and characterized. It was determined that clone 46 hybridizes to the extreme 5′ end of λ3NT12. pMJE12, a 3.0 × 103-base-pair fragment in the 5′ region of λ3NT12, was subcloned in plasmid pBR322 and used as a probe to screen again the same mouse-DNA library; recombinant phages λ3NT13, λ3NT14, and λAhP-1 were isolated and characterized. The relative orientation of each of the four genomic clones on the mouse chromosome was determined. Only λAhP-1 contains the entire P1-450 genomic gene, which by R-loop analysis spans about 46 × 102 base pairs and contains at least five exons. Clone 46 is shown to be a 3′ unique sequence of the genomic P1-450 gene. The λAhP-1 genomic-DNA clone from the MOPC 41 plasmocytoma is shown by a series of restriction enzymes to be the same as genomic DNA from normal mouse liver. With a subclone in the 5′ portion of the P1-450 gene, two and three hybridizable fragments are found with mouse genomie DNA that has been digested with EcoRI and BamHI, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - MOLECULAR cloning
KW - CHROMOSOMES
KW - GENES
KW - ENZYMES
KW - CELL receptors
KW - MESSENGER RNA
KW - RECOMBINANT DNA
KW - BIOCHEMISTRY
N1 - Accession Number: 13832525; Nakamura, Michitoshi 1 Negishi, Masahiko 1 Altieri, Mario 1 Yuan-Tsong Chen 1 Ikeda, Toshihiko 1 Tukey, Robert H. 1 Nebert, Daniel W. 1; Affiliation: 1: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/83, Vol. 134 Issue 1, p19; Subject Term: CYTOCHROME P-450; Subject Term: MOLECULAR cloning; Subject Term: CHROMOSOMES; Subject Term: GENES; Subject Term: ENZYMES; Subject Term: CELL receptors; Subject Term: MESSENGER RNA; Subject Term: RECOMBINANT DNA; Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holbrook, Karen A.
AU - Hennings, Henry
T1 - Phenotypic Expression of Epidermal Cells in Vitro: A Review.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 11s
EP - 24s
SN - 0022202X
AB - Disaggregated epidermal cells, sheets of epidermis, and explants of partial and full-thickness skin have been grown in cell, organ, and explant cultures. Each type of epidermal sample has also been "cultured" as a graft on a living animal host. The extent of tissue-specific phenotypic expression by the epidermal cell varies with the type of culture and the culture conditions: medium, biologic and pharmacologic additives, substrate, cell density, ph, and temperature. Specific culture conditions can be chosen to select for certain phenotypic traits, in spite of the diversity of conditions that may be used for culture, keratinocytes in cell, explant, and organ cultures undergo a similar pattern of differentiation. They stratify and keratinize, but rarely express a complete program of keratinization. Many of the characteristics associated with this pattern of differentiation are also observed in fetal epidermis during development. In culture, normal tissue architecture is usually absent; cells organize in flattened, loosely associated layers, synthesize a different pattern of keratin polypeptides, form keratohyalin granules only sporadically, and rarely contain lamellar granules. Epidermal differentiation in explant and organ cultures can be evaluated in regions of the explant, epibolic zone, and outgrowth apron. The epidermis of the original explant undergoes hyperproliferation, degeneration, sloughing, and then regeneration of a thin tissue. The cells in the epithelial outgrowth zone stratify and differentiate almost identically with those in cell culture. Neogenesis of structures in the basement-membrane zone can be followed in all three regions of the explant culture, Sheets of epidermis or epidermal cells transplanted onto or into a host animal show the most complete expression of the epidermal phenotype. After a period of hyperplastic growth, the cell layers become established in a pattern nearly identical to that in vivo. A complete granular layer is formed and stratum corneum cells, which are structurally and biochemically equivalent to those in tissue, differentiate. In some instances, the epidermis reconstructed from cells or tissue is indistinguishable from adjacent host epidermis. Experiments that include serial transfer from one culture system to another demonstrate the plasticity of the epidermal cell and its ability to respond variously to its environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - EPIDERMIS
KW - CELLS
KW - KERATINOCYTES
KW - TISSUES
KW - KERATIN
N1 - Accession Number: 12540003; Holbrook, Karen A. 1 Hennings, Henry 2; Affiliation: 1: Departments of Biological Structure and Medicine (Dermatology), University of Washington School of Medicine, Seattle, Washington 2: Laboratory of Cellular Carcinogenesis, and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul83 Supplement, Vol. 81, p11s; Subject Term: SKIN; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: KERATINOCYTES; Subject Term: TISSUES; Subject Term: KERATIN; Number of Pages: 14p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hennings, Henry
AU - Holbrook, Karen A.
AU - Yuspa, Stuart H.
T1 - Potassium Mediation of Calcium-Induced Terminal Differentiation of Epidermal Cells in Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 50s
EP - 55s
SN - 0022202X
AB - Epidermal cells cultured in low-calcium medium (0.02- 0.1 mM) grow as a monolayer, in contrast to the stratified pattern of growth in medium with standard calcium levels (1.2-1.8 mM). These low-calcium cells lack desmosomes and maintain a high proliferation rate. Raising the extracellular calcium to >0.1 mM induces rapid desmosome formation followed by stratification, inhibition of proliferation, formation of cornified envelopes, and sloughing of the cells from the culture dish. This calcium-induced terminal differentiation program is characterized by an increase in the intracellular levels of sodium and potassium at 12 to 24 hours and is not blocked by inhibitors of calcium or sodium flux. Of 40 to 50 agents tested as inhibitors of calcium-induced epidermal differentiation, only ouabain, harmaline, A23187, and 8(diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) were effective. These agents did not block the earliest calcium-induced effect (desmosome formation), but they did inhibit later stages in the program of terminal differentiation. Their detailed mechanism of action is unclear, although ouabain inhibits the sodium pump (Na+K+ATPase), lowering potassium and elevating sodium in the cells. The other inhibitors also prevented the calcium-induced elevation of intracellular potassium with no common effect on intracellular sodium. Reduction of potassium in the medium from the usual level of 6.5 mM to 0.1 mM lowers intracellular potassium by 60 to 70 percent and prevents calcium-induced differentiation, This result, along with the inhibitor studies, suggests that potassium plays an important role in epidermal terminal differentiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - POTASSIUM
KW - CALCIUM
KW - CELLS
KW - SODIUM
KW - SKIN
N1 - Accession Number: 12540491; Hennings, Henry 1 Holbrook, Karen A. 2 Yuspa, Stuart H. 1; Affiliation: 1: In Vitro Pathogenesis Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. 2: Department of Biological Structural and Medicine (Dermatology,), University of Washington, Seattle, Washington, U S A.; Source Info: Jul83 Supplement, Vol. 81, p50s; Subject Term: EPIDERMIS; Subject Term: POTASSIUM; Subject Term: CALCIUM; Subject Term: CELLS; Subject Term: SODIUM; Subject Term: SKIN; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540491
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steinert, Peter M.
AU - Steven, Alasdair C.
AU - Roop, Dennis R.
T1 - Structural Features of Epidermal Keratin Filaments Reassembled in Vitro.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 86s
EP - 90s
SN - 0022202X
AB - We have studied the structure of epidermal keratin filaments polymerized in vitro, addressing two different levels of organization. First, we have determined the amino acid sequence of a mouse epidermal keratin subunit from the nucleotide sequence of a eDNA clone. The subunit contains a large central region, representing about 50 percent, whose sequence strongly suggests that it assumes a coiled-coil α-helical conformation. This is flanked on the amino and carboxyl terminals by long glycine-rich sequences. Second, we have used scanning transmission electron microscopy to study the structure of frozen, unstained filaments. Analyses of such images provides information on the mass per unit length and on the distribution of mass within the filament. These data impose rigorous constraints on possible models for the packing of protofilaments within the filament. Epidermal keratin filaments assembled in vitro are polymorphic; however, the majority of bovine filaments weigh about 37 kD/nm, but most human filaments have masses of only about 27 kD/nm, The filament width is at least 15 nm, substantially more than the generally accepted value of 8 to 10 nm, owing to the existence of low-density mass at the periphery that has not been visualized by conventional microscopic methods. We currently postulate that the α-helical regions of the subunits comprise the structural core or backbone of the filament from which at least some of the glycine-rich sequences protrude. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - KERATIN
KW - SCANNING transmission electron microscopy
KW - AMINO acids
KW - GLYCINE
KW - SKIN
N1 - Accession Number: 12540757; Steinert, Peter M. 1 Steven, Alasdair C. 2 Roop, Dennis R. 3; Affiliation: 1: Dermatology Branch and Laboratory of Cellular Carcinogenesis, Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A. 2: Laboratory of Physical Biology, National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A. 3: Tumor Promotion, National Cancer Institute, Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, U S A.; Source Info: Jul83 Supplement, Vol. 81, p86s; Subject Term: EPIDERMIS; Subject Term: KERATIN; Subject Term: SCANNING transmission electron microscopy; Subject Term: AMINO acids; Subject Term: GLYCINE; Subject Term: SKIN; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540757
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dale, Beverly A.
AU - Scofield, Julie A. Haugen
AU - Hennings, Henry
AU - Stanley, John R.
AU - Yuspa, Stuart H.
T1 - Identification of Filaggrin in Cultured Mouse Keratinocytes and Its Regulation by Calcium.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 90s
EP - 95s
SN - 0022202X
AB - Filaggrin is a histidine-rich cationic protein present in cells of the stratum corneum in vivo and derived from a precursor in keratohyalin granules. Biochemical and immunologic methods were used to determine the presence of filaggrin in keratinocytes cultured in vitro and induced to differentiate by increasing the extracellular calcium concentration from 0.07 to 1.2 mM. Indirect immunofluorescence using antibody to rat filaggrin was negative in cells cultured in low-calcium medium but positive in cells switched to high-calcium medium. Large immunofluorescent granules were identified in a perinuclear distribution starting at 6 hours after the shift in calcium concentration, coinciding with the time of appearance of phase-dense cytoplasmic granules. Radiolabeled histidine was preferentially incorporated into proteins of 95, 37, and 27 K. The 37 and 27 K bands were not adsorbed by DE52 cellulose and therefore are cationic. A 27 K cationic, histidine-labeled protein was readily extracted from frozen pellets of cells cultured in high-calcium medium. It comigrates with purified mouse filaggrin (27 K) and reacts with antibody to rat filaggrin on immunoautoradiography. Only trace amounts of this protein could be detected in cells cultured in low-calcium medium. Our observation of filaggrin-immunoreactive granules confirms the previous ultrastructural identification of keratohyalin granules after the shift to high-calcium medium. The results suggest that filaggrin synthesis is stimulated in keratinocytes induced to differentiate by the shift to high extracellular calcium concentration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - KERATINOCYTES
KW - CALCIUM
KW - CELLS
KW - CELLULOSE
KW - PROTEINS
N1 - Accession Number: 12540769; Dale, Beverly A. 1,2 Scofield, Julie A. Haugen 1 Hennings, Henry 3 Stanley, John R. Yuspa, Stuart H. 3; Affiliation: 1: Departments of Periodontics, University of Washington, Seattle, Washington. 2: Department of Medicine (Dermatology), University of Washington, Seattle, Washington. 3: In Vitro Pathogenesis Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Mary/and.; Source Info: Jul83 Supplement, Vol. 81, p90s; Subject Term: MICE; Subject Term: KERATINOCYTES; Subject Term: CALCIUM; Subject Term: CELLS; Subject Term: CELLULOSE; Subject Term: PROTEINS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540769
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roop, Dennis R.
AU - Hawley-Nelson, Pamela
AU - Cheng, Christina K.
AU - Vuspa, Stuart H.
T1 - Expression of Keratin Genes in Mouse Epidermis and Normal and Malignantly Transformed Epidermal Cells in Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 144s
EP - 149s
SN - 0022202X
AB - Complementary DNA (cDNA) clones constructed to the 55, 59 and 67 kilodalton (K) keratins, the major keratins synthesized in newborn mouse epidermis, were used as molecular hybridization probes to examine the expression of these genes in newborn epidermis and normal and malignantly transformed epidermal cells in culture. Transcripts of these three keratin genes are abundant in newborn epidermis. However, primary cultures of epidermal cells contain very low levels of these RNAs, The decreased expression of these keratin genes in primary cells appears to be due to factors within the culture system. Unlike primary-cell cultures, the malignantly transformed cell line Pam 212 synthesizes keratin proteins and mRNAs similar to newborn epidermis, including the 67 K keratin, However, synthesis of the 67 K keratin in Pam 212 cells is modulated by culture factors. Keratin gene expression in another Pam line, 321, differs from that of Pam 212 cells in that decreased expression of these three keratin genes occurs. These results indicate that keratin genes that are normally expressed in vivo in epidermis may be expressed in malignant epidermal cells under conditions that do not permit expression of these genes in nonmalignant primary epidermal cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATIN
KW - GENES
KW - MICE
KW - EPIDERMIS
KW - CELL culture
KW - CELL lines
N1 - Accession Number: 12540939; Roop, Dennis R. 1 Hawley-Nelson, Pamela 1 Cheng, Christina K. Vuspa, Stuart H. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Jul83 Supplement, Vol. 81, p144s; Subject Term: KERATIN; Subject Term: GENES; Subject Term: MICE; Subject Term: EPIDERMIS; Subject Term: CELL culture; Subject Term: CELL lines; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540939
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuspa, Stuart H.
AU - Kulesz-Martin, Molly
AU - Ben, Theresa
AU - Hennings, Henry
T1 - Transformation of Epidermal Cells in Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/07/15/Jul83 Supplement
VL - 81
M3 - Article
SP - 162s
EP - 168s
SN - 0022202X
AB - Studies performed on mouse skin have indicated that chemical carcinogenesis can be subdivided into two distinct stages, initiation and promotion. Initiation results from exposure to a classical mutagenic carcinogen and is irreversible even after a single exposure. The permanently altered initiated cell and its progeny may never form a tumor or in any way be recognizable in the target tissue, Exposure to tumor promoters permits the expression of the neoplastic change in initiated cells, and tumors develop. In contrast to initiators, promoters must be given repeatedly to be effective; individual exposures are reversible, A similar biology is suggested by epidemiologic studies of certain human cancers, particularly lung, breast, colon, and uterine malignancies. Studies in mouse skin cell culture have provided new insights into the changes associated with initiation and promotion. Initiated cells appear to be resistant to signals for terminal differentiation and can proliferate under conditions where normal epidermal cells are obligated to cease proliferation and begin their maturation program. This change is essential for an epithelial tumor cell since it provides the ability to grow away from a basement- membrane attachment site, In cultured epidermal cells, tumor promoters are capable of selectively stimulating the growth of certain cells, including initiated cells, while simultaneously inducing terminal differentiation in other epidermal cells, The net effect of these responses to promoters is the clonal expansion of cells stimulated to proliferate. In this way, promoters are capable of increasing the clone size of initiated cells. These cell culture data provided a biological framework for under- standing initiation and promotion in terminally differentiating epithelial tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - CELLS
KW - CARCINOGENESIS
KW - TUMORS
KW - MICE
KW - EPITHELIAL cells
N1 - Accession Number: 12540999; Yuspa, Stuart H. 1 Kulesz-Martin, Molly 1 Ben, Theresa 1 Hennings, Henry 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U S A.; Source Info: Jul83 Supplement, Vol. 81, p162s; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: CARCINOGENESIS; Subject Term: TUMORS; Subject Term: MICE; Subject Term: EPITHELIAL cells; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12540999
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ER -
TY - JOUR
AU - DOOLITTLE, RUSSELL F.
AU - HUNKAPIWLER, MICHAEL W.
AU - HOOD, LEROY E.
AU - DEVARE, SUSHILKUMAR G.
AU - ROBBINS, KEITH C.
AU - AARONSON, STUART A.
AU - ANTONIADES, HARRY N.
T1 - Simian Sarcoma Virus onc Gene, v-sis, Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor.
JO - Science
JF - Science
Y1 - 1983/07/15/
VL - 221
IS - 4607
M3 - Article
SP - 275
EP - 277
SN - 00368075
AB - The transforming protein of a primate sarcoma virus and a plateletderived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derivedfrom the simian sarcoma virus onc gene, vsis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 84672938; DOOLITTLE, RUSSELL F. 1; HUNKAPIWLER, MICHAEL W. 2; HOOD, LEROY E. 2; DEVARE, SUSHILKUMAR G. 3; ROBBINS, KEITH C. 3; AARONSON, STUART A. 3; ANTONIADES, HARRY N. 4; Affiliations: 1: Department of Chemistry, University of California, San Diego, La Jolla 92093; 2: Division of Biology, California Institute of Technology, Pasadena 91125; 3: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; 4: Center for Blood Research and Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p275; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - KALEBIC, TEA
AU - GARBISA, S.
AU - GLASER, B.
AU - LIOTTA, L. A.
T1 - Basement Membrane Collagen: Degradation by Migrating Endothelial Cells.
JO - Science
JF - Science
Y1 - 1983/07/15/
VL - 221
IS - 4607
M3 - Article
SP - 281
EP - 283
SN - 00368075
AB - One of thefirst steps in neovascularizaton is dissolution of the basement membrane at the point of endothelial outgrowth. An assay was developed to determine whether basement membrane collagens (types IV and V) are degraded by endothelial cells migrating toward a chemotactic stimulus. Fetal bovine endothelial cells were placed on one side of a filter containing the collagen substrate, and a chemoattractant derived from retinal extracts was placed on the opposite side. Degradation of both type IV and type V collagens was observed when the retinal factor was placed on the side of the filter opposite the endothelial cells. Metalloproteinases that cleaved type IV and type V collagens could be extracted from the endothelial cells with detergents. Such endothelial cell-associated (possibly membrane- bound) proteinases may locally disrupt the basement membrane andfacilitate the outgrowth of capillary sprouts toward the angiogenic stimulus [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 84672941; KALEBIC, TEA 1; GARBISA, S. 2; GLASER, B. 3; LIOTTA, L. A. 4; Affiliations: 1: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20205; 2: Institute of Histology, Padova, Italy; 3: Department of Ophthalmolc Johns Hopkins University, Baltimore, Maryland 21205; 4: Laboratory of Pathology, National Cancer Institute; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p281; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - CHOI, EDMUND
AU - MCINTYRE, KATHERINE
AU - GERMAIN, RONALD N.
AU - SEIDMAN, J. G.
T1 - Murine I-Aβ Chain Polymorphism: Nucleotide Sequences of Three Allelic I-Aβ Genes.
JO - Science
JF - Science
Y1 - 1983/07/15/
VL - 221
IS - 4607
M3 - Article
SP - 283
EP - 286
SN - 00368075
AB - The polymorphism of immune response genes plays a critical role in determining the immune capabilities of a particular individual. The molecular nature of this polymorphism was studied by examining the structure of the coding portions of three alleles of the I-AP chain gene, an immune response gene whose protein product constitutes a subunit of the I-A molecule. Comparison of the I-AP chains encoded by these alleles revealed an amino acid sequence divergence of S to 8 percent. The differences werefound to be a series of short alterations clustered in the amino terminal half of the polypeptide. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 84672942; CHOI, EDMUND 1; MCINTYRE, KATHERINE 1; GERMAIN, RONALD N. 2; SEIDMAN, J. G. 3; Affiliations: 1: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; 3: Department of Genetics, Harvard Medical School; Issue Info: 7/15/1983, Vol. 221 Issue 4607, p283; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - WEINGARTNER, HERBERT
AU - GRAFMAN, JORDAN
AU - BOUTELLE, WILLIAM
AU - KAYE, WALTER
AU - MARTIN, PETER R.
T1 - Forms of Memory Failure.
JO - Science
JF - Science
Y1 - 1983/07/22/
VL - 221
IS - 4608
M3 - Article
SP - 380
EP - 382
SN - 00368075
AB - Memory may fail in a variety of ways. Patients with Korsakoff's syndrome demonstrate global memory deficits similar to those seen in patients with early progressive dementia. Korsakoff's patients, however, may recall rules and principles for organizing information and can gain access to their previously acquired knowledge (semantic memory), whereas recent memory may be grossly impaired. In contrast, dementia patients may have little access to previously acquired knowledge and therefore have great difficulty in organizing and encoding ongoing events. These contrasting forms of memory failure have implications for understanding the structure and mechanisms of memory and learning, particularly the relationship between episodic and semantic memory, as well as the development of therapeutic strategies for cognitive impairments. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 84672983; WEINGARTNER, HERBERT 1; GRAFMAN, JORDAN 2; BOUTELLE, WILLIAM 3; KAYE, WALTER 4; MARTIN, PETER R. 5; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Walter Reed Army Medical Center, Washington, D.C. 20307; 3: Veterans Administration Hospital, Northampton, Massachusetts 01060; 4: National Institute of Mental Health; 5: National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20205; Issue Info: 7/22/1983, Vol. 221 Issue 4608, p380; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - O'BRIEN, STEPHEN J.
AU - WILDT, DAVID E.
AU - GOLDMAN, DAVID
AU - MERRIL, CARL R.
AU - BUSH, MITCHELL
T1 - The Cheetah Is Depauperate in Genetic Variation.
JO - Science
JF - Science
Y1 - 1983/07/29/
VL - 221
IS - 4609
M3 - Article
SP - 459
EP - 462
SN - 00368075
AB - A sample of 55 South African cheetahs (Acinonyx jubatus jubatus) from two geographically isolated populations in South Africa were found to be genetically monomorphic at each of 47 allozyme (allelic isozyme) loci. Two-dimensional gel electrophoresis of 155 abundant soluble proteins from cheetah fibroblasts also revealed a low frequency of polymorphism (average heterozygosity, 0.013). Both estimates are dramatically lower than levels of variation reported in other cats and mammals in general. The extreme monomorphism may be a consequence of a demographic contraction of the cheetah (a population bottleneck) in association with a reduced rate of increase in the recent natural history of this endangered species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673021; O'BRIEN, STEPHEN J. 1; WILDT, DAVID E. 1; GOLDMAN, DAVID 2; MERRIL, CARL R. 3; BUSH, MITCHELL 4; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205; 3: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health; 4: National Zoological Park, Smithsonian Institution, Washington, D.C. 20008; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p459; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HATCH, CHRISTOPHER L.
AU - BONNER, WILLIAM M.
AU - MOUDRIANAKIS, EVANGELOS N.
T1 - Minor Histone 2A Variants and Ubiquinated Forms in the Native H2A:H2B Dimer.
JO - Science
JF - Science
Y1 - 1983/07/29/
VL - 221
IS - 4609
M3 - Article
SP - 468
EP - 470
SN - 00368075
AB - Histone octamers from calf thymus were separated into (H3:H4)2 tetramers and H2A:H2B dimers by chromatography through Sephadex GIOO. The tetramers and dimers were analyzedfor variants, ubiquitin adducts, and proteolyzed forms. The minor histone variants H2A.X and H2A.Z were found to be associated with histone H2B as H2A.X:H2B and H2A.Z:H2B dimers, respectively. Ubiquitin adducts of the H2A's and H2B were also present in H2A:H2B dimers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673025; HATCH, CHRISTOPHER L. 1; BONNER, WILLIAM M. 2; MOUDRIANAKIS, EVANGELOS N. 3; Affiliations: 1: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218; 2: Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 3: Department of Biology, Johns Hopkins University; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p468; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - WEINGARTNER, HERBERT
AU - RUDORFER, MATTHEW V.
AU - BUCHSBAUM, MONTE S.
AU - LINNOILA, MARKKU
T1 - Effects of Serotonin on Memory Impairments Produced by Ethanol.
JO - Science
JF - Science
Y1 - 1983/07/29/
VL - 221
IS - 4609
M3 - Article
SP - 472
EP - 474
SN - 00368075
AB - Subjects treated with low or high doses of ethanol demonstrated impaired memory, particularly in tests involving the recall of poorly learned information. Zimelidine, an inhibitor of serotonin reuptake, reversed this ethanolinduced impairment. The serotonin neurotransmitter system may mediate learning and memory in humans and may determine some of the effects of alcohol on higher mental functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673027; WEINGARTNER, HERBERT 1; RUDORFER, MATTHEW V. 1; BUCHSBAUM, MONTE S. 2; LINNOILA, MARKKU 3; Affiliations: 1: National Institute of Mental Health, Bethesda, Maryland 20205; 2: Department of Psychiatry, University of California, Irvine 92717; 3: National Institute of Alcoholism and Alcohol Abuse, Bethesda, Maryland 20205; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p472; Number of Pages: 3p; Document Type: Article
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TY - JOUR
AU - GARRICK, NANCY A.
AU - TAMARKIN, LAWRENCE
AU - TAYLOR, PHILIP L.
AU - MARKEY, SANFORD P.
AU - MURPHY, DENNIS L.
T1 - Light and Propranolol Suppress the Nocturnal Elevation of Serotonin in the Cerebrospinal Fluid of Rhesus Monkeys.
JO - Science
JF - Science
Y1 - 1983/07/29/
VL - 221
IS - 4609
M3 - Article
SP - 474
EP - 476
SN - 00368075
AB - Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinalfluid were reduced to daytime levels by exposing the monkeys to continuous light or to the, -adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673028; GARRICK, NANCY A. 1,2; TAMARKIN, LAWRENCE 3; TAYLOR, PHILIP L. 4; MARKEY, SANFORD P. 5; MURPHY, DENNIS L. 6; Affiliations: 1: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Physiology Division, Department of Zoology, University of Maryland, College Park 20742; 3: Intramural Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 4: MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, EH3 9EW Scotland; 5: Laboratory of Clinical Science, National Institute of Mental Health; 6: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 7/29/1983, Vol. 221 Issue 4609, p474; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Chrest, F. J.
AU - Nagel, J. E.
AU - Pyle, R. S.
AU - Adler, W. H.
T1 - Human B cell function in responder and non-responder indiviuals. II. The role of T helper cells in promoting the PWM-induced B cell production of immunoprotein.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/08//
VL - 53
IS - 2
M3 - Article
SP - 465
EP - 472
PB - Wiley-Blackwell
SN - 00099104
AB - Sorted OKT4+ cells treated with pokeweed mitogen (PWM) and subsequently X-irradiated were used as a source of helper T cells to examine human T and B cell function. PWM-induced immunoprotein synthesis by human peripheral blood lymphocytes was the model used to study cellular interactions. PWM was shown to induce helper T cell function which caused non-PWM treated B cells to secrete immunoglobulin. PBL from certain individuals could not be induced by PWM to secrete Ig therefore allogeneic co-cultures of helper T cells and B cells were examined to define the defective cell population. Ig synthesis allogeneic cultures of T and B cells was always greater than that observed in autologous cultures when cells from responders were assayed. However, when allogenic cultures were initiated using B cells from a responder and PWM treated T cells from a non-responder and examined for Ig synthesis, the B cell responses were markedly lower than seen in the autologous responder cultures. In addition, PWM activated helper T cells from a responder induced a significantly higher Ig synthesis by B cells from a non-responder. These observations indicate that PBL from individuals who do not respond in a PWM driven Ig synthesis assay have relatively normal B cell function but are deficient in helper T cell function. [ABSTRACT FROM AUTHOR]
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KW - POKEWEED mitogens
KW - B cells
KW - T cells
KW - PROTEINS
KW - LEUCOCYTES
KW - IMMUNOGLOBULINS
KW - B cell function
KW - helper T cells
KW - pokeweed mitogen
N1 - Accession Number: 16017343; Chrest, F. J. 1 Nagel, J. E. 1 Pyle, R. S. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore, USA.; Source Info: Aug1983, Vol. 53 Issue 2, p465; Subject Term: POKEWEED mitogens; Subject Term: B cells; Subject Term: T cells; Subject Term: PROTEINS; Subject Term: LEUCOCYTES; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: B cell function; Author-Supplied Keyword: helper T cells; Author-Supplied Keyword: pokeweed mitogen; Number of Pages: 8p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Stevenson, H. C.
AU - Miller, P. J.
AU - Waxdal, M. J.
AU - Haynes, B. F.
AU - Thomas, C. A.
AU - Fauci, A. S.
T1 - Interaction of pokeweed mitogen with monocytes in the activation of human lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1983/08//
VL - 49
IS - 4
M3 - Article
SP - 633
EP - 640
PB - Wiley-Blackwell
SN - 00192805
AB - The present study examines the role of monocytes in the in-vitro activation of human T cells and B cells by pokeweed mitogen (PWM). The T cell-dependent PWM-induced B-cell activation process was found to be monocyte dependent. Fluorescence-activated cell sorter (FACS) analysis revealed that upon addition to peripheral blood mononuclear cells, fluoresceinated PWM, at concentrations that provided optimal B-cell and T-cell activation, bound predominantly to human monocytes. The binding of PWM to monocytes was reversible and could be displaced within the first few hours of binding by oligomers of N-acetylglucosamine (GlcNAc). As a functional correlate of the binding studies, it was shown that PWM-pulsed monocytes could induce B lymphocytes to become plaque-forming cells (PFC) and T lymphocytes to undergo proliferation. In contrast, markedly reduced PFC and blastogenic responses were observed when monocyte-depleted B lymphocytes and T lymphocytes were respectively pulsed with PWM and washed, followed by the addition of non-PWM-pulsed monocytes to the cultures. Thus, the initial event in the PWM-induced activation of human lymphocytes, for both in-vitro T-lymphocyte blastogenic responses and B-lymphocyte Ig secretion, appears to be binding of the mitogen to sugar residues on the surface membrane of the monocyte, followed by subsequent interaction with the appropriate lymphocytes. The process of PWM binding to monocytes did not appear to affect the baseline production of interleukin-1 (IL-1) by human monocytes, nor could soluble factors from PWM-pulsed monocytes substitute for intact cells in the initiation of the lymphocyte-activation process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCYTES
KW - T cells
KW - POKEWEED mitogens
KW - PLANT lectins
KW - INTERLEUKINS
KW - OLIGOMERS
N1 - Accession Number: 13523299; Stevenson, H. C. 1 Miller, P. J. 1 Waxdal, M. J. 1 Haynes, B. F. 1 Thomas, C. A. 1 Fauci, A. S. 2; Affiliation: 1: Biological Therapeutics Branch, Biological Response Modifiers Program, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland and Laboratory of Immunoregulation and Laboratory of Immunology, National Institute of Allergy. 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug83, Vol. 49 Issue 4, p633; Subject Term: MONOCYTES; Subject Term: T cells; Subject Term: POKEWEED mitogens; Subject Term: PLANT lectins; Subject Term: INTERLEUKINS; Subject Term: OLIGOMERS; Number of Pages: 8p; Document Type: Article
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ER -
TY - JOUR
AU - Woodley, David
AU - Sauder, Daniel
AU - Talley, Mary Jane
AU - Silver, Michael
AU - Grotendorst, Gary
AU - Qwarnstrom, Eva
T1 - Localization of Basement Membrane Components After Dermal-Epidermal Junction Separation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/08//
VL - 81
IS - 2
M3 - Article
SP - 149
EP - 153
SN - 0022202X
AB - Adult human skin was separated at the dermal-epidermal junction (DEJ) by 4 published methods that involved different mechanisms of action: cold 1 M salt (tissue extraction), cold trypsinization (enzymatic), induction of a suction blister (mechanical), and warm phosphate- buffered saline (protease activation). The localization of DEJ macromolecules was studied after each separation method. By all of the methods tested, bullous pemphigoid antigen remained closely associated with the epidermis while laminin, the basement membrane heparan sulfate proteoglycan, and collagen types IV and V remained with the dermal side of the separation. The bullous pemphigoid antigen is, then, the DEJ component most closely associated with the epidermal basal cell. Of the basement membrane components tested, only the basement membrane heparan sulfate proteoglycan was trypsin-sensitive. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - DERMIS
KW - ANTIGENS
KW - PROTEOGLYCANS
KW - COLLAGEN
KW - TRYPSIN
N1 - Accession Number: 12543517; Woodley, David 1 Sauder, Daniel 2 Talley, Mary Jane 2 Silver, Michael 1 Grotendorst, Gary 1 Qwarnstrom, Eva 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: National Institute of Dental Research and Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug83, Vol. 81 Issue 2, p149; Subject Term: EPIDERMIS; Subject Term: DERMIS; Subject Term: ANTIGENS; Subject Term: PROTEOGLYCANS; Subject Term: COLLAGEN; Subject Term: TRYPSIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12543517
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DB - aph
ER -
TY - JOUR
AU - GORMAN, CORNELIA
AU - PADMANABHAN, RAJI
AU - HOWARD, BRUCE H.
T1 - High Efficiency DNA-Mediated Transformation of Primate Cells.
JO - Science
JF - Science
Y1 - 1983/08/05/
VL - 221
IS - 4610
M3 - Article
SP - 551
EP - 553
SN - 00368075
AB - Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyl transferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10-3 (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 × 10-2 (6 percent). [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673067; GORMAN, CORNELIA 1; PADMANABHAN, RAJI 1; HOWARD, BRUCE H. 1; Affiliations: 1: Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 8/ 5/1983, Vol. 221 Issue 4610, p551; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROWE, WALLACE P.
T1 - Deformed Whiskers in Mice Infected with Certain Exogenous Murine Leukemia Viruses.
JO - Science
JF - Science
Y1 - 1983/08/05/
VL - 221
IS - 4610
M3 - Article
SP - 562
EP - 564
SN - 00368075
AB - Mice infected at birth with replication competent Friend, Moloney, Cas- Br-M, C2S-M, and 1504-A murine leukemia viruses developed abnormalities of the vibrissae consisting of erratic curvature, shortening, and loss. A number of other virus strains, as well as endogenous AKR-type ecotropic virus and AKR-type, mink cellfocus-inducing (MCF) viruses, did not produce these abnormalities. In mice with erythroid and myeloid leukemia, the perivibrissal sinus is the site of extramedullary hematopoiesis, but this did not appear to be the basis of the deformities. Genetic evidence indicated that newly arisen MCF-type recombinant viruses are involved in the pathogenesis of the abnormalities, at least with some of the virus systems studied. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673072; ROWE, WALLACE P. 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Issue Info: 8/ 5/1983, Vol. 221 Issue 4610, p562; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NAMBOODIRI, M. A. A.
AU - SUGDEN, D.
AU - KLEIN, D. C.
AU - MEFFORD, I. N.
T1 - 5-Hydroxytryptophan Elevates Serum Melatonin.
JO - Science
JF - Science
Y1 - 1983/08/12/
VL - 221
IS - 4611
M3 - Article
SP - 659
EP - 661
SN - 00368075
AB - Daytime administration of 5-hydroxytryptophan to sheep elevated serum melatonin more than sevenfold within 2 hours. This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85483660; NAMBOODIRI, M. A. A. 1; SUGDEN, D. 1; KLEIN, D. C. 1; MEFFORD, I. N. 2; Affiliations: 1: Section, Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02167; Issue Info: 8/12/1983, Vol. 221 Issue 4611, p659; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Barneveld, Ruud A.
AU - Tegelaers, Frans P. W.
AU - Ginns, Edward I.
AU - Visser, Pim
AU - Laanen, Elly A.
AU - Brady, Roscoe O.
AU - Galjaard, Hans
AU - Barranger, John A.
AU - Reuser, Arnold J. J.
AU - Tager, Joseph M.
T1 - Monoclonal Antibodies against Human β-Glucocerebrosidase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/08/15/
VL - 134
IS - 3
M3 - Article
SP - 585
EP - 589
PB - Wiley-Blackwell
SN - 00142956
AB - Monoclonal antibodies were obtained against the membrane-bound lysosomal enzyme β-glucocerebrosidase (acid β-glucosidase), which is deficient in Gaucher's disease. BALB/c mice were immunized with homogeneous enzyme protein extracted from a sodium dodecyl sulphate/polyacrylamide gel. The mice were subsequently hyperimmunized with partially purified enzyme prior to fusion of spleen cells with myeloma cells. After fusion, 32 primary hybrid cell populations were obtained which continued to produce antibodies against β-glucocerebrosidase after prolonged time of culture. All antibodies reacted with both native and denatured enzyme. Four primary cell populations were subcloned and the antibodies produced were characterized. The antibodies were all four of the IgG1 subclass. Three of these antibodies bind to protein A whereas one does not. The results of binding assays indicated that three of the antibodies react with the same antigenic domain (epitope 1), but the fourth with a different one (epitope 2). Probably two antigenic determinants are present in epitope 1 since one of the antibodies with specificity for epitope 1 is inactivated after iodination by the chloramine-T procedure whereas a second one is not. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - CELL membranes
KW - GAUCHER'S disease
KW - ENZYMES
KW - MYELOMA proteins
N1 - Accession Number: 13918899; Barneveld, Ruud A. 1 Tegelaers, Frans P. W. 2 Ginns, Edward I. 3 Visser, Pim 1 Laanen, Elly A. 2 Brady, Roscoe O. 3 Galjaard, Hans 1 Barranger, John A. 3 Reuser, Arnold J. J. 1 Tager, Joseph M. 2; Affiliation: 1: Department of Cell Biology and Genetics Erasmus University Rotterdam 2: Laboratory of Biochemistry University of Amsterdam 3: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda; Source Info: 8/15/83, Vol. 134 Issue 3, p585; Subject Term: MONOCLONAL antibodies; Subject Term: CELL membranes; Subject Term: GAUCHER'S disease; Subject Term: ENZYMES; Subject Term: MYELOMA proteins; Number of Pages: 5p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SCHWARTZ, M.
AU - DUARA, R.
AU - HAXBY, J.
AU - GRADY, C.
AU - WHITE, B. J.
AU - KESSLER, R. M.
AU - KAY, A. D.
AU - CUTLER, N. R.
AU - RAPOPORT, S. I.
T1 - Down's Syndrome in Adults: Brain Metabolism.
JO - Science
JF - Science
Y1 - 1983/08/19/
VL - 221
IS - 4612
M3 - Article
SP - 781
EP - 783
SN - 00368075
AB - The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a Si-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673121; SCHWARTZ, M. 1; DUARA, R. 1; HAXBY, J. 1; GRADY, C. 1; WHITE, B. J. 2; KESSLER, R. M. 3; KAY, A. D. 4; CUTLER, N. R. 4; RAPOPORT, S. I. 4; Affiliations: 1: Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20205; 2: Laboratory of Cell Biology and Genetics, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health; 3: Department of Nuclear Medicine, National Institutes of Health; 4: Laboratory of Neurosciences, National Institute on Aging; Issue Info: 8/19/1983, Vol. 221 Issue 4612, p781; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LAUTENBERGER, JAMES A.
AU - ULSH, LINDA
AU - SHIH, THOMAS Y.
AU - PAPAS, TAKiS S.
T1 - High-Level Expression in Escherichia coli of Enzymatically Active Harvey Murine Sarcona Virus p21 ras Protien.
JO - Science
JF - Science
Y1 - 1983/08/26/
VL - 221
IS - 4613
M3 - Article
SP - 858
EP - 860
SN - 00368075
AB - The gene for the Harvey murine sarcoma virus (Ha-MuSV) p2lras protein was fused to the amino-terminal portion of the bacteriophage λ cII gene on the expression vector pJL6. Thefusion was such tht transcription was controlled by the well-regulated phage λPL promoter, and translation initiated in the cII gene continued in frame into the ras gene, sequences that code for p21. When the PL promoter was derepressed, the Escherichia coli cells harboring the fusion plasmid synthesized 23,000-dalton protein, which represented more than 10 percent of the total cellular protein. This protein was chimeric and contained 14 residues, which were specified by the vector; these residues-were followed by all of the amino acids that make up Ha-MuSV p2lras except for four residues at the amino-terminal end. The protein appears similar to Ha-MuSV p21ras in that it undergoes immunoprecipitation by monoclonal antibodies directed toward that protein, binds guanosine diphosphate, and is capable of autophosphorylation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673151; LAUTENBERGER, JAMES A. 1; ULSH, LINDA 1; SHIH, THOMAS Y. 1; PAPAS, TAKiS S. 1; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Bethesda, Maryland 2Q205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p858; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KOZAK, CHRISTINE A.
AU - SEARS, JOHNNA F.
AU - HOGGAN, M. DAVID
T1 - Genetic Mapping of the Mouse Proto-Oncogene c-sis to Chromosome 15.
JO - Science
JF - Science
Y1 - 1983/08/26/
VL - 221
IS - 4613
M3 - Article
SP - 867
EP - 869
SN - 00368075
AB - The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA'sfrom hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or duplications of chromosome 15. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673155; KOZAK, CHRISTINE A. 1; SEARS, JOHNNA F. 1; HOGGAN, M. DAVID 1; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p867; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROSENSTEIN, JEFFREY M.
AU - BRIGHTMAN, MILTON W.
T1 - Circumventing the Blood-Brain Barrier with Autonomic Ganglion Transplants.
JO - Science
JF - Science
Y1 - 1983/08/26/
VL - 221
IS - 4613
M3 - Article
SP - 879
EP - 881
SN - 00368075
AB - Superior cervical ganglia, whose vessels are fenestrated and permeable to protein tracers such as horseradish peroxidase, were transplanted to undamaged surfaces in the fourth ventricle of rat pup brains. Horseradish peroxidase, infused systemically into the host, was exuded from the graft's vessels into the graft's extracellular stroma within I minute. At later times the glycoprotein reached the extracellular clefts of adjacent brain tissue, the vessels of which appeared to retain their impermeability. The blood-brain barrier to horseradish peroxide was thus bypassed where the extracellular compartments of graft and brain became confluent. The graft of autonomic ganglia can serve as a portal through which peptides, hormones, and immunoglobulins may likewise enter the brain [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673161; ROSENSTEIN, JEFFREY M. 1; BRIGHTMAN, MILTON W. 2; Affiliations: 1: Department ofAnatomy, George Washington University Medical Center, Washington, D.C. 20037; 2: Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 8/26/1983, Vol. 221 Issue 4613, p879; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Kovar, Mary Grace
AU - Hiller, Rita
AU - Krueger, Eean E.
AU - Green, Lawrence W.
AU - Bauer, Katherine G.
AU - Gordon, Nancy P.
AU - Belcastro, Philip A.
AU - Sachs, Michael L.
AU - Yamamoto, Loren
AU - Yano, Katsuhiko
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/09//
VL - 73
IS - 9
M3 - Letter
SP - 1101
PB - American Public Health Association
SN - 00900036
AB - Several letters to the editor are presented in response to articles in previous issues including "Beyond the Statistics of Adolescent Smoking," by P. Eckert that was published in an issue, "In Support of Jogging," by Dr. M. A. Ibrahim, and the "Editor's Report: LPU, The Nation's Health and Other Matters," by A. Yankauer that was published in an issue.
KW - LETTERS to the editor
KW - CIGARETTE smokers
KW - TEENAGERS
KW - JOGGING
KW - MEDICAL policy
KW - PUBLIC health
N1 - Accession Number: 4948721; Kovar, Mary Grace 1 Hiller, Rita 2 Krueger, Eean E. 3 Green, Lawrence W. 4 Bauer, Katherine G. 5 Gordon, Nancy P. Belcastro, Philip A. 6 Sachs, Michael L. 7 Yamamoto, Loren 8 Yano, Katsuhiko 8; Affiliation: 1: Special Assistant, Data Policy and Analysis Office of Interview and Examination Statistics Program, NCHS, PHS, DHHS, Washington. 2: Office of Biometry and Epidemiology, National Eye Institute, Rockville. 3: Biostatistics Center, George Washington University, Bethesda. 4: Center for Health Promotion, Research, and Development, University of Texas Health Sciences Center, Houston. 5: Scholar-in-Residence, Institute of Medicine, Washington. 6: Assistant Professor, Dept of Health Education, Southern Illinois Univ., Carbondale. 7: Professor, Departement des Sciences de l'activite physique, Universite du Quebec, C.P 500, Quebec. 8: Honolulu Heart Program, Kuakina Medical Center, 347 N. Kuakini St. Honolulu, HI 96817.; Source Info: Sep83, Vol. 73 Issue 9, p1101; Subject Term: LETTERS to the editor; Subject Term: CIGARETTE smokers; Subject Term: TEENAGERS; Subject Term: JOGGING; Subject Term: MEDICAL policy; Subject Term: PUBLIC health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Small, Arnold
AU - Madero, James
AU - Teagno, Lorie
AU - Ebert, Michael
T1 - INTELLECT, PERCEPTUAL CHARACTERISTICS, AND WEIGHT GAIN IN ANOREXIA NERVOSA.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1983/09//
VL - 39
IS - 5
M3 - Article
SP - 780
EP - 782
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article focuses on the study of weight gain among the patients of Anorexia Nervosa. The few investigations in the past decade that have examined the thinking and perceptual processes of anorexics have provided a fairly consistent picture in that they have found striking disturbances in both for a significant number. Researchers studied the results of the age-appropriate Wechsler Scale and the Rorschach of a group of anorexics in an attempt to determine whether psychodiagnostjc indices may be associated with weight gain. 27 subjects were successively admitted anorexics to the behavior modification weight gain program. Multiple regression analyses, using percent weight gain as a continuous criterion, were conducted separately for Wechsler subtest scales and Rorschach determinants. The results of the multiple regression analyses suggest that the Wechsler Scale is more important than perceptual-personality variables in predicting weight gain for anorexics in a behavior modification program.
KW - WEIGHT gain
KW - ANOREXIA nervosa
KW - BODY weight
KW - MENTAL disabilities
KW - INTELLIGENCE tests
KW - REGRESSION analysis
N1 - Accession Number: 19108600; Small, Arnold 1 Madero, James 2 Teagno, Lorie 3 Ebert, Michael 4; Affiliation: 1: George Mason University Family and Child Development Services of Virginia. 2: United States International University. 3: University of Maryland. 4: National Institute of Mental Health.; Source Info: Sep1983, Vol. 39 Issue 5, p780; Subject Term: WEIGHT gain; Subject Term: ANOREXIA nervosa; Subject Term: BODY weight; Subject Term: MENTAL disabilities; Subject Term: INTELLIGENCE tests; Subject Term: REGRESSION analysis; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Riley, Matilda White
T1 - The Family in an Aging Society: A Matrix of Latent Relationships.
JO - Journal of Family Issues
JF - Journal of Family Issues
Y1 - 1983/09//
VL - 4
IS - 3
M3 - Article
SP - 439
EP - 454
SN - 0192513X
AB - Because of unprecedented increases in longevity, the kinship structure has been transformed. Linkages among family members have been prolonged, and the surviving generations in a family have increased in number and complexity. Today's kinship structure (which has no parallel in history) can be viewed in a new way: as a latent web of continually shifting linkages that provide the potential for activating and intensifying close family relationships. These relationships are no longer prescribed as strict obligations, but must be earned-created and recreated by family members over their lives. Such changes in the structure and dynamics of family relationships raise many questions and issues for students of the family including the development of special research approaches needed to understand the complexity of these relationships and the nature of older people's family relationships in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAMILIES
KW - FAMILY relations
KW - KINSHIP
KW - SOCIAL psychology
KW - AFFINITY (Kinship)
N1 - Accession Number: 13543958; Riley, Matilda White 1; Source Information: Sep1983, Vol. 4 Issue 3, p439; Subject: FAMILIES; Subject: FAMILY relations; Subject: KINSHIP; Subject: SOCIAL psychology; Subject: AFFINITY (Kinship); Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Luger, Thomas A.
AU - Stadler, Beda M.
AU - Luger, Bia M.
AU - Sztein, Marcelo B.
AU - Schmidt, John A.
AU - Hawley-Nelson, Pamela
AU - Grabner, Gunther
AU - Oppenheim, Joost J.
T1 - Characteristics of an Epidermal Cell Thymocyte-Activating Factor (ETAF) Produced by Human Epidermal Cells and a Human Squamous Cell Carcinoma Cell Line.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/09//
VL - 81
IS - 3
M3 - Article
SP - 187
EP - 193
SN - 0022202X
AB - In this study we show that both cultured normal human epidermal cells (EC) and a human squamous cell carcinoma (SCC) cell line produce a thymocyte-activating factor (ETAF). EC-ETAF and SCC-ETAF both have a Mr of 15,000 and were eluted from chromatofocusing at the same isoelectric points of 7.2, 5.8, and 5.0. Both activities were maintained at alkaline pH and were destroyed at temperatures above 60°C. In addition to stimulating thymocyte proliferation, human ETAF exhibited a variety of other pertinent biologic activities. Although EC-ETAF or SCC-ETAF by themselves exhibited no T-cell growth factor activity, both ETAF preparations enhanced Interleukin 2 production by cultured human peripheral blood lymphocytes when stimulated with polyclonal T-cells stimulants (Concanavalin A and phorbol myristate acetate). Human ETAF also was chemotactic for rabbit polymorphonuclear leukocytes and was directly mitogenic for cultured human dermal fibroblasts. Injection of human ETAF into C3H/HeJ mice, resulted in inducing serum amyloid A (SAA) production by murine hepatocytes. The thymocyte growth-enhancing activity, the fibroblast-stimulating activity, and the SAA-inducing capacity of ETAF all coeluted off AcA54 gel. These biologic as well as biochemical properties of human keratinocyte-derived ETAF are identical with those of human macrophage-derived Interleukin 1. The ability of keratinocytes to release an immunomodulating factor with such diverse consequences may play an important role in normal wound healing and in diseases involving epithelial tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SQUAMOUS cell carcinoma
KW - T cells
KW - LYMPHOCYTES
KW - BLOOD
KW - CANCER cells
KW - LEUCOCYTES
N1 - Accession Number: 12517658; Luger, Thomas A. 1,2,3,4 Stadler, Beda M. 1,2,3,4 Luger, Bia M. 1,2,3,4 Sztein, Marcelo B. 1,2,3,4 Schmidt, John A. 1,2,3,4 Hawley-Nelson, Pamela 1,2,3,4 Grabner, Gunther 1,2,3,4 Oppenheim, Joost J.; Affiliation: 1: Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland. 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. 3: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 4: Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, California, U.S.A.; Source Info: Sep83, Vol. 81 Issue 3, p187; Subject Term: SQUAMOUS cell carcinoma; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: BLOOD; Subject Term: CANCER cells; Subject Term: LEUCOCYTES; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12517658
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ROBISON JR., W. GERALD
AU - KADOR, PETER F.
AU - KINOSHITA, JIN H.
T1 - Retinal Capillaries: Basement Membrane Thickening by Galactosemia Prevented with Aldose Reductase Inhibitor.
JO - Science
JF - Science
Y1 - 1983/09/16/
VL - 221
IS - 4616
M3 - Article
SP - 1177
EP - 1179
SN - 00368075
AB - A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673271; ROBISON JR., W. GERALD 1; KADOR, PETER F. 1; KINOSHITA, JIN H. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20205; Issue Info: 9/16/1983, Vol. 221 Issue 4616, p1177; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - JOFFE, JUSTIN M.
AU - KIMBALL, A. W.
AU - MUKHERJEE, ANIL B.
AU - HODGEN, GARY D.
T1 - Alcohol and Pregnancy.
JO - Science
JF - Science
Y1 - 1983/09/23/
VL - 221
IS - 4617
M3 - Article
SP - 1244
EP - 1245
SN - 00368075
N1 - Accession Number: 84673287; JOFFE, JUSTIN M. 1; KIMBALL, A. W. 2; MUKHERJEE, ANIL B. 3; HODGEN, GARY D. 3; Affiliations: 1: Department of Psychology, Dewey Hall, University of Vermont, Burlington 05405; 2: Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205; 3: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1244; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SONDEREGGER, PETER
AU - FISHMAN, MARK C.
AU - BOKOUM, MADINA
AU - BAUER, HANS C.
AU - NELSON, PHILLIP G.
T1 - Axonal Proteins of Presynaptic Neurons During Synaptogenesis.
JO - Science
JF - Science
Y1 - 1983/09/23/
VL - 221
IS - 4617
M3 - Article
SP - 1294
EP - 1297
SN - 00368075
AB - Changes occur in the synthesis and axonal transport of neuronal proteins in dorsal-root ganglia axons as a result of contact with cells from the spinal cord during synapse formation. Dorsal-root ganglia cells were cultured in a compartmental cell culture system that allows separate access to neuronal cell bodies and their axons. When cells from the ventral spinal cord were cultured with the dorsal-root ganglia axons, synapses were established within a few days. Metabolic labeling and two-dimensionat electrophoresis revealed that four of more than 300 axonal proteins had changed in their expression by the time synapses were established. The highly selective nature of these changes suggests that the proteins involved may be important in the processes of axon growth and synapse formation and their regulation by the regional environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673314; SONDEREGGER, PETER 1; FISHMAN, MARK C. 1; BOKOUM, MADINA 1; BAUER, HANS C. 1; NELSON, PHILLIP G. 1; Affiliations: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1294; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MEMO, MAURIZIO
AU - KLEINMAN, JOEL E.
AU - HANBAUER, INGEBORG
T1 - Coupling of Dopamine D1 Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics.
JO - Science
JF - Science
Y1 - 1983/09/23/
VL - 221
IS - 4617
M3 - Article
SP - 1304
EP - 1307
SN - 00368075
AB - Sodium fluoride, guanylimidodiphosphate, and the D1 dopamine receptor agonist SKF 38393 elicited a greater activation of adenylate cyclase in homogenates of caudate nucleus in schizophrenic than in nonschizophrenic subjects used as controls. Similarly, a greater activation of adenylate cyclase by sodium fluoride was observed in the nucleus accumbens of schizophrenics. These findings suggest that the coupling of dopamine D1 recognition sites with adenylate cyclase is more efficient in the brain of the schizophrenic, presumably because of an increased affinity of the GIF protein for guanosine 5'-triphosphate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84673318; MEMO, MAURIZIO 1; KLEINMAN, JOEL E. 2; HANBAUER, INGEBORG 1; Affiliations: 1: Section on Biochemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; Issue Info: 9/23/1983, Vol. 221 Issue 4617, p1304; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Rennard, S. I.
AU - Yuang-Fang Chen
AU - Robbins, R. A.
AU - Gadek, J. E.
AU - Crystal, R. G.
T1 - Fibronectin mediates cell attachment to Clq: a mechanism for the localization of fibrosis in inflammatory disease.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/10//
VL - 54
IS - 1
M3 - Article
SP - 239
EP - 247
PB - Wiley-Blackwell
SN - 00099104
AB - Chronic inflammatory processes frequently lead to the abnormal replacement of normal tissue elements by increased numbers of fibroblasts and fibrous connective tissue, i.e., fibrosis. Since the growth of fibroblasts requires that these cells be attached to an extracellular support, the current study was designed to determine if the interaction between the fibroblast attachment factor fibronectin and the Clq component of complement could support fibroblast attachment and growth and thus could form a basis for the attachment of fibroblasts in abnormal tissue locations in those inflammatory states where Clq is bound. Fibronectin purified from human plasma supported attachment of both Chinese hamster ovary cells and of normal fetal lung fibroblasts (HFL-1) to Clq coated substrates. The attachment activity was approximately twice that of attachment to collagen, and was specific, as no attachment occurred to albumin coated substrates. Cells attached to Clq substrates demonstrated characteristic "spreading" similar to those on collagen. Moreover, the Clq substrate resembled collagen in its ability to support fibroblast growth. Further, the ability of the interaction between Clq and fibronectin to mediate attachment of fibroblasts to immune complexes was demonstrated by the formation of fibroblast-red blood cell-immune complex rosettes, a process that was dependent on both fibronectin and Clq, Thus, the interaction between fibronectin and Clq could serve as the basis for fibroblast attachment and growth in abnormal tissue sites where immune complexes are formed and could be a contributing factor to the development of fibrosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - COLLAGEN
KW - CONNECTIVE tissues
KW - EXTRACELLULAR matrix proteins
KW - IMMUNOGLOBULINS
KW - BLOOD cells
KW - cell attachment
KW - Clq
KW - Fibronectin
KW - fibrosis
KW - immune complexes
N1 - Accession Number: 16308328; Rennard, S. I. 1 Yuang-Fang Chen 1 Robbins, R. A. 1 Gadek, J. E. 1 Crystal, R. G. 1; Affiliation: 1: Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Oct1983, Vol. 54 Issue 1, p239; Subject Term: FIBROBLASTS; Subject Term: COLLAGEN; Subject Term: CONNECTIVE tissues; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD cells; Author-Supplied Keyword: cell attachment; Author-Supplied Keyword: Clq; Author-Supplied Keyword: Fibronectin; Author-Supplied Keyword: fibrosis; Author-Supplied Keyword: immune complexes; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosling, Bengt G.
AU - Slots, Jørgen
AU - Webber, Richard L.
AU - Christersson, Lars A.
AU - Genco, Robert J.
T1 - Microbiological and clinical effects of topical subgingival antimicrobial treatment on human periodontal disease.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1983/10//
VL - 10
IS - 5
M3 - Article
SP - 487
EP - 514
SN - 03036979
AB - This study was undertaken to evaluate the microbiological and clinical effects of a subgingivally applied mixture of H2O2-NaCl and NaHCO3 followed by subgingival irrigation with 1% Betadine® in the treatment of periodontal disease. 20 adults with moderate to severe periodontal disease were included in a split mouth design study. All patients were given oral hygiene instruction and were subjected to supragingival scaling in all 4 quadrants, and subgingival scaling and root planing of half the dentition. 10 patients were instructed to use the chemical antimicrobial mixture twice a day instead of dentifrice, and also received professional application of the mixture once every 14 days for 3 months in connection with reinstruction in oral hygiene procedures. The remaining 10 patients received oral hygiene instructions combined with professional tooth cleaning without use of chemicals once every 14 days during a 3-month period. The effect of treatment was evaluated by monitoring the subgingival microflora, clinical periodontal parameters, and by computer assisted subtraction analysis of serial standardized radiographs to determine changes in mass of the supporting alveolar bone. The present study revealed that subgingival debridement combined with mechanical plaque control resulted in decreased numbers of subgingival microorganisms including spirochetes and motile rods, and arrested the progressive breakdown of the periodontal tissues. Topical antimicrobial agents used in combination with subgingival scaling further reduced the subgingival microflora and substantially improved early periodontal healing including gain of probing attachment level and gain in radiographic alveolar bone mass during the 12 months of observation. No clinical improvement but a tendency to further periodontal breakdown was found in the unscaled quadrants, even in those which were subjected to a personal application of the topical antimicrobial mixture. This study indicates that professional and personal subgingival application of a mixture of H2O2-NaCl and NaHCO3 will significantly enhance the microbiological and clinical effects of periodontal scaling and root planing. These agents, and the topical mode of antimicrobial therapy seem promising in the management of human periodontal diseases. (English) [ABSTRACT FROM AUTHOR]
AB - Le but de cette étude a été l'évaluation des effets cliniques et microbiologiques sur la maladie parodontale de l'application sousgingivale d'un mélange de H2O2-NaCl et de NaHCO3suivie d'une irrigation au Betadine® 1%. L'étude a porté sur 20 adultes atteints de maladie parodontale maodérée à sévère dont la bouche a été divisée en 2 quadrants d'expérimentation et 2 quadrants témoins. Tous les patients ont reçu des instructions d'hygiène buccale, un détartrage sousgingival et un lissage radiculaire de 2 quadrants. La moitié des patients a utilisé le mélange antimicrobien chirnique 2 fois par jour à la place de dentifrice et reccedil;u également une application professionnelle de ce mélange toutes les 2 semaines durant 3 mois et des instructions renouvelées d'hygiène buccale. L'autre moitié des patients a reçu des instructions d'hygiène buccale accompagnées d'un nettoyage professionnel sans utilization de produits chimiques une fois toutes les 2 semaines pendant 3 mois. L'effet du traitement a été évalué en enregistrant la sousgingivale, les paramètres parodontaux cliniques et la variation quantitative de masse osseuse en analysant par ordinateur la soustraction entre différentes radiographies superposables. La présente étude a révelé que le détartrage sous gingival associé à un contrôle mécanique de la plaque entrînait une diminution du nombre de microorganisms sousgingivaux tells que bâtonnets motiles et spirochètes, et arrêtait la progression de la maladie parodontale. Les agents antimicrobiens associés au détartrage sousgingval réduisaient davantage la microflore sousgingivale et amélioraient signficativement la cicatrisation parodontale initiale entraînant entre autre un gain du niveau d'attache au sondage et de la masse ossuese durant les 12 mois d'observation. Aucune amélioration clinique n'a été notée dand les quadrants non détartrés en sousgingival. Au contraire une tandance à l'aggravation de la maladie parodontale était constatée dans ces quadrants, même lorsqu'ils avaient reçu une application topique individuelle du mélange antimicrobien. Cette étude montre que l'application individuelle et professionnelle d'un mélange de H2O2-NaCl et de NaHCO3 augmente significativement les effets microbiologiques et cliniques de détartrage et du lissage radiculaire. Ces agents et l'application topique d'une thérapie antimicrobeinne semblent prometteurs pour traiter dans l'avenir la maladie parodontale humaine. (French) [ABSTRACT FROM AUTHOR]
AB - Um bei der Behandlung der Parodontalkrankheit mikrobiologische und klinische Folgen einer subgingival administrierten Lösung von H2O2-NaCl und NaHCO3, bei dann anschliessender subgingivaler Irrigation mit 1%-iger Betadin®-Lösung zu erproben, wurde die hier vorliegende Studie konzipiert. An 20 Erwachsenen mit mässigen bis schweren parodontalen Erkrankungen wurde eine klinische Studie vom "split mouth"- Typ durchgeführt. Alle Probanden erhielten eingangs Instruktionen über die Durchfürung oraler Hygienemassnahmen. Ausserdem wurde der supragingivale Zahnstein aller 4 Quadranten entfernt, Subgingivale Zahnsteinfernung und Wurzelglättung wurde jedoch nur in einer der beiden Gebisshälften vorgenommen. 10 Probanden wurden angewiesen, anstelle einer Zahnpaste, die hier aktuelle chemisch-antimikrobielle Lösung anzuwenden. Darüberhinaus wurde, zusammen mit einer Re-Instruktion über die Durcliführung der oralen Hygiene, die chemisch-antimikrobielle Lösung in 2-wöchentlichen Abständen einmal professionell appliziert. Die verbleibenden 10 Probanden wurden 2 Monate lang in 2-wöchentlichen Abständen in der Durchführung oraler Hygienemassnahmen re-instruiert, jedoch ohne Applikation der chemisch-antimikrobiellen Lösung. Die Bewertung des Behandlungserfolges wurde durch Registrieren der subgingivalen Mikroflora, klinisch-parodontaler Parameter und durch eine datorisierte Subtraktionsanalyse standardisierter Serienröntgenbilder (zur Feststellung von Mengenänderungen des alveolaren Stützknochens) vorgenommen. Die Studie konnete zeigen, dass subgingivale Depuration bei gleichzeitiger mechanischer Plaquekontrolle eine Verringerund der Vorkommenshäufigkeit subgingivaler Mikroorganismen -- einschliesslich der Spirochaeten und der beweglichen Stäbchen - erreichte und weitere Auflösung parodontaler Gewebe aufhalten konnte. Darüberhinaus reduzierten local administrierte antimikrobielle Wirkstoffe - bei gleichzeitiger subgingivaler Zahnsteinentfernung - die subgingivale Mikroflora während der 12-monatlichen Beobachtungszeit noch weiter. Die frühe parodontale Heilung wurde deutlich gefördert. Ausserdem erschien das Niveau des sondierten Attachments sich in günstigerer Lage zu befinden und die röntgenologisch ermittelte Menge alveolaren Stützknochens hatte sich vergrössert. In den Quandranten, in denen kein Zahnstein entfernt wurde, sah man nicht nur keine Anzeichen klinischer Verbesserung, sondern auch die Tendenz zu weitergehender parodontaler Auflösung - such dann, wenn die Probanden selber die antimikrobielle Lösung appliziert hatten. Diese Studie zeigt, dass professionelle und eigene subgingivale Applikation einer Mischung des H2O3-NaCl mit NaHCO3, die mikrobiologische und klinsiche Wirkung parodontaler Zahnsteinentfernung verstärkt. Solche Wirkstoffe, sowie ihrelokale Applikationsform bei der antimikrobiellen Therapie, scheinen für die Behandlung der menschlichen Parodontalkrankheit interessant und vielversprechend zu sein. (German) [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTICS
KW - MICROBIOLOGY
KW - MICROORGANISMS
KW - BACTERIAL diseases
KW - PERIODONTAL disease
KW - ANTI-infective agents
KW - Probing attachment level
KW - subgingival microflora
KW - topical antimicrobial treatment.
N1 - Accession Number: 13500479; Rosling, Bengt G. 1 Slots, Jørgen 1 Webber, Richard L. 1 Christersson, Lars A. 1 Genco, Robert J. 2; Affiliation: 1: Department of Oral Biology and Periodontal Disease Clinical Research Center, School of Dentistry, State University of New York at Buffalo, Buffalo, NY. 2: National Institute of Dental Research and National Institutes of Health, Bethesda, MA, U.S.A.; Source Info: Oct1983, Vol. 10 Issue 5, p487; Subject Term: PERIODONTICS; Subject Term: MICROBIOLOGY; Subject Term: MICROORGANISMS; Subject Term: BACTERIAL diseases; Subject Term: PERIODONTAL disease; Subject Term: ANTI-infective agents; Author-Supplied Keyword: Probing attachment level; Author-Supplied Keyword: subgingival microflora; Author-Supplied Keyword: topical antimicrobial treatment.; Number of Pages: 28p; Document Type: Article
L3 - 10.1111/1600-051X.ep13500479
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Iijima, Masafumi
AU - Katz, Stephen I.
T1 - Specific Immunologic Tolerance to Dinitrofluorobenzene Following Topical Application of Dinitrothiocyanobenzene: Modulation by Suppressor T Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/10//
VL - 81
IS - 4
M3 - Article
SP - 325
EP - 330
SN - 0022202X
AB - In order to determine the mechanism(s) involved in the induction of immunologic tolerance for contact sensitivity via the topical application of a chemical that sensitizes if given with adjuvant, we utilized the hapten dinitrothiocyanobenzene (DNTB). Specific immunologic tolerance to dinitrofluorobenzene (DNFB) was induced in mice by the topical application of DNTB 7 days before sensitization to DNFB. The tolerance could be abrogated if cyclophosphamide (200 mg/kg) was given 3 days before attempted sensitization. Using passive transfer studies we found that DNTB induced hapten-specific Lyt 1+2- suppressor T cells. These suppressor cells prevented the induction of contact sensitivity but did not affect its expression. Lymphocyte proliferation studies, using haptenated epidermal cells as antigen, indicate that lymph node cells obtained 5 days after DNFB sensitization are far less responsive if the mice have received DNTB epicutaneously 7 days before the DNFB. Binding studies demonstrated that DNTB bound to epidermal cells at least as well as did DNFB. It is postulated that DNTB induction of suppressor cells is related to the physicochemical interaction between the hapten and antigen-presenting cells in skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGIC diseases
KW - T cells
KW - DINITROBENZENES
KW - LYMPHOCYTES
KW - SUPPRESSOR cells
KW - EPIDERMIS
N1 - Accession Number: 12519783; Iijima, Masafumi 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S. A.; Source Info: Oct83, Vol. 81 Issue 4, p325; Subject Term: IMMUNOLOGIC diseases; Subject Term: T cells; Subject Term: DINITROBENZENES; Subject Term: LYMPHOCYTES; Subject Term: SUPPRESSOR cells; Subject Term: EPIDERMIS; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12519783
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lynch, David H.
AU - Gurish, Michael F.
AU - Daynes, Raymond A.
T1 - The Effects of High-Dose UV Exposure on Murine Langerhans Cell Function at Exposed and Unexposed Sites as Assessed Using In Vivo and In Vitro Assays.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/10//
VL - 81
IS - 4
M3 - Article
SP - 336
EP - 341
SN - 0022202X
AB - Exposure of mice to a single large dose of UV radiation leads to a systemic inability of these mice to develop effective contact hypersensitivity (CS) responses to epicutaneously applied dinitrofluorobenzene (DNFB). Although this effect requires time to develop when unirradiated skin sites are used for CS sensitization, it is observed immediately at the site of UV exposure. Unirradiated skin sites on mice exposed to a single large dose of UV radiation 3 days previously were found to contain histochemically detectable ATPase+ cells with normal morphology and in normal densities, and yet CS responses were not induced to DNFB applied to these sites. Epidermal cells (EC) obtained from these skin sites were found to be capable of providing accessory cell (AC) function in in vitro T-cell proliferation assays that was qualitatively similar to EC obtained from unirradiated mice, thus indicating that exposure of mice to a single large dose of UV radiation does not induce a systemic AC dysfunction. Indeed, increased levels of AC activity were obtained in EC prepared from the UV-irradiated skin sites on the third day following UV exposure. This latter effect may be due to an influx of inflammatory cells into the irradiated site in response to the tissue damage caused by the UV radiation. We hypothesize that the inflammatory response induced by the cytodestructive effects of the UV treatment may play a central role in the generation of the systemic suppression of induction of CS responses, perhaps through the induction of acute-phase proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - LANGERHANS cells
KW - ULTRAVIOLET radiation
KW - HISTOCHEMISTRY
KW - T cells
KW - MICE as laboratory animals
N1 - Accession Number: 12519910; Lynch, David H. 1 Gurish, Michael F. 2 Daynes, Raymond A. 3; Affiliation: 1: Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205. 2: Rosenstiel Research Center, Brandeis University, Waltham, Massachusetts 02254. 3: Departments of Obstetrics/Gynecology and Pathology, University of Utah Medical Center, Salt Lake City, Utah, U.S.A.; Source Info: Oct83, Vol. 81 Issue 4, p336; Subject Term: SKIN -- Inflammation; Subject Term: LANGERHANS cells; Subject Term: ULTRAVIOLET radiation; Subject Term: HISTOCHEMISTRY; Subject Term: T cells; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12519910
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rölla, Gunnar
AU - Amsbaugh, Suzanne M.
AU - Monell-Torrens, Esteban
AU - Ellingsen, Jan-Eirik
AU - Afseth, John
AU - Ciardi, Joseph E.
AU - Bowen, William H.
T1 - Effect of topical application of stannous fluoride, stannous chloride and stannous tartrate on rat caries.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1983/10//
VL - 91
IS - 5
M3 - Article
SP - 351
EP - 355
SN - 0029845X
AB - Topical application of 10mM aqueous solutions of stannous fluoride inhibited caries in rats to a higher degree than 20 mM sodium fluoride, although the difference was not statistically significant. Furthermore, stannous fluoride reduced the number of Strep. mutans in plaque significantly; stannous ions have an antibacterial effect. Stannous chloride and stannous tartrate did not reduce caries in the rats, probably because of the low concentrations of available stannous ions in these solutions at low pH. The high concentration of stannous ions in solutions of stannous fluoride is probably partly due to the reduced hydroxide formation resulting from the buffering effect of HF formed at low pH in this solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries
KW - TIN
KW - FLUORIDES
KW - CHLORIDES
KW - RATS as laboratory animals
KW - DENTAL research
KW - caries inhibition
KW - metal ions
KW - trace elements
N1 - Accession Number: 13161550; Rölla, Gunnar 1 Amsbaugh, Suzanne M. 1 Monell-Torrens, Esteban 1 Ellingsen, Jan-Eirik 2 Afseth, John 2 Ciardi, Joseph E. 1 Bowen, William H. 3; Affiliation: 1: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Dental Faculty, University of Oslo, Oslo, Norway. 3: University of Rochester, Medical Center, Rochester, New York, U.S.A.; Source Info: 1983, Vol. 91 Issue 5, p351; Subject Term: DENTAL caries; Subject Term: TIN; Subject Term: FLUORIDES; Subject Term: CHLORIDES; Subject Term: RATS as laboratory animals; Subject Term: DENTAL research; Author-Supplied Keyword: caries inhibition; Author-Supplied Keyword: metal ions; Author-Supplied Keyword: trace elements; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RISCH, SAMUEL C.
AU - KALIN, NED H.
AU - JANOWSKY, DAVID S.
AU - COHEN, ROBERT M.
AU - PICKAR, DAVID
AU - MURPHY, DENNIS L.
T1 - Co-Release of ACTH and β-Endorphin Immunoreactivity in Human Subjects in Response to Central Cholinergic Stimulation.
JO - Science
JF - Science
Y1 - 1983/10/07/
VL - 222
IS - 4619
M3 - Article
SP - 77
EP - 77
SN - 00368075
N1 - Accession Number: 84671661; RISCH, SAMUEL C. 1; KALIN, NED H. 2; JANOWSKY, DAVID S. 3; COHEN, ROBERT M. 4; PICKAR, DAVID 5; MURPHY, DENNIS L. 6; Affiliations: 1: Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, 92093; 2: Department of Psychiatry, School of Medicine, University of Wisconsin, Madison, Wisconsin, 53141; 3: Department of Psychiatry, School of Medicine, University of California, San Diego; 4: Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, 20205; 5: Biological Psychiatry Branch, National Institute of Mental Health; 6: Clinical Neuropharmacology Branch, National Institute of Mental Health; Issue Info: 10/ 7/1983, Vol. 222 Issue 4619, p77; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sargent, Thomas D.
AU - Dawid, Igor B.
T1 - Differential Gene Expression in the Gastrula of Xenopus laevis.
JO - Science
JF - Science
Y1 - 1983/10/14/
VL - 222
IS - 4620
M3 - Article
SP - 135
EP - 139
SN - 00368075
N1 - Accession Number: 85483678; Sargent, Thomas D. 1; Dawid, Igor B. 1; Affiliations: 1: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20205; Issue Info: 10/14/1983, Vol. 222 Issue 4620, p135; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NEEDLEMAN, SAMUEL W.
AU - YUASA, YASUHITO
AU - SRIVASTAVA, SHIV
AU - AARONSON, STUART A.
T1 - Normal Cells of Patients with High Cancer Risk Syndromes Lack Transforming Activity in the NHI/3T3 Transfection Assay.
JO - Science
JF - Science
Y1 - 1983/10/14/
VL - 222
IS - 4620
M3 - Article
SP - 173
EP - 175
SN - 00368075
AB - Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85483702; NEEDLEMAN, SAMUEL W. 1; YUASA, YASUHITO 1; SRIVASTAVA, SHIV 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular, Biology, National Cancer Institute, Bethesda, Maryland, 20205; Issue Info: 10/14/1983, Vol. 222 Issue 4620, p173; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEINSTEIN, JOHN N.
AU - STELLER, MICHAEL A.
AU - KEENAN, ANDREW M.
AU - COVELL, DAVID G.
AU - KEY, MARC E.
AU - SIEBER, SUSAN M.
AU - OLDHAM, ROBERT K.
AU - HWANG, Kou M.
AU - PARKER, ROBERT J.
T1 - Monoclonal Antibodies in the Lymphatics: Selective Delivery to Lymph Node Metastases of a Solid Tumor.
JO - Science
JF - Science
Y1 - 1983/10/28/
VL - 222
IS - 4622
M3 - Article
SP - 423
EP - 426
SN - 00368075
AB - After subcutaneous injection, monoclonal antibodies directed against a tumor can enter local lymphatic vessels, pass to the draining lymph nodes, and bind to metastases there. Lymphatic delivery of antibody to early metastases is more efficient than intravenous administration, and the lymphatic route can be used to image smaller metastatic deposits. Perhaps more important, the lymphatic route minimizes binding of antibodies to circulating tumor antigens and to cross-reactive antigens present on normal tissues. Antibodies inappropriate for intravenous use because of binding to normal tissues may therefore be useful against lymph node metastases when injected subcutaneously or directly into lymphatic vessels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671729; WEINSTEIN, JOHN N. 1; STELLER, MICHAEL A. 1; KEENAN, ANDREW M. 2; COVELL, DAVID G. 3; KEY, MARC E. 4; SIEBER, SUSAN M. 5; OLDHAM, ROBERT K. 6; HWANG, Kou M. 6; PARKER, ROBERT J. 5; Affiliations: 1: Laboratory of Theoretical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Department of Nuclear Medicine, Clinical Center, National Institutes of Health; 3: Laboratory of Theoretical Biology, National Cancer Institute; 4: Cancer Metastasis and Treatment Laboratory, NCI-Frederick Cancer Research Facility, Frederick, Maryland 21701; 5: Office of the Director, Division of Cancer Cause and Prevention, National Cancer Institute; 6: Biological Response Modifiers Program, NCI-Frederick Cancer Research Facility; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p423; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GIALLONGO, AGATA
AU - APPELLA, ETTORE
AU - RICCIARDI, ROBERT
AU - ROVERA, GIOVANNI
AU - CROCE, CARLO M.
T1 - Identification of the c-myc Oncogene Product in Normal and Malignant B Cells.
JO - Science
JF - Science
Y1 - 1983/10/28/
VL - 222
IS - 4622
M3 - Article
SP - 430
EP - 432
SN - 00368075
AB - Antiserum to a synthetic peptide corresponding to the carboxyl-terminus of the human c-myc protein immunoprecipitated a 48,000-dalton protein from a number of normal and malignant human and mouse cells. The size of the protein is consistent with the potential coding region predicted from the c-myc nucleotide sequence, and is the same for malignant cells carrying either a rearranged or an unrearranged c-myc oncogene. Because c-myc transcripts are expressed at higher levels in malignant than in normal B cells, it appears that an increased level of the cmyc protein rather than a change in the gene product is the relevant factor in determining transformation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671732; GIALLONGO, AGATA 1; APPELLA, ETTORE 2; RICCIARDI, ROBERT 3; ROVERA, GIOVANNI 3; CROCE, CARLO M. 3; Affiliations: 1: Wistar Institute, 36th and Spruce Street, Philadelphia, Pennsylvania 19104; 2: Laboratory of Cell Biology, National Cancer Institute Bethesda, Maryland 20205; 3: Wistar Institute and Graduate Group of Molecular Biology, University of Pennsylvania, 36th and Spruce Street, Philadelphia, Pennsylvania 19104; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p430; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yoakum, George H.
AU - Korba, Brent E.
AU - Lechner, John F.
AU - Tokiwa, Takayoshi
AU - Gazdar, Adi F.
AU - Seeley, Todd
AU - Siegel, Mary
AU - Leeman, Lawrence
AU - Autrup, Herman
AU - Harris, Curtis C.
T1 - High-Frequency Transfection and Cytopathology of the Hepatitis B Virus Core Antigen Gene in Human Cells.
JO - Science
JF - Science
Y1 - 1983/10/28/
VL - 222
IS - 4622
M3 - Article
SP - 585
EP - 389
SN - 00368075
AB - A protoplast fusion method was developed to stably transfect human cells with pSV2-derived plasmids at frequencies greater than 10-3. This procedure made it possible to test the biological effect of a hepatitis B virus (HBV) gene independent of the viral structures required for infection. A pSV2gpt+ plasmid constructed to carry a subgenomic fragment of HBV that contained the core antigen gene (HBc gene) was transfected into human cells. A human epithelial cell line was stably transfected with the HBc+ gene by selecting recipient cells for expression of guanine phosphoribosyl transferase expression. With this gpt+/HBc+ cell line it was shown that growth in serum-free medium or treatment with 5'-azacytidine stimulates the production of the HBV core antigen. A hepatocellular carcinoma carrying the entire HBV genome was stimulated to produce the HBc gene product in response to the same factors that stimulated HBcAg production in the gpt+/HBc+ cell line constructed by transfection. The temporal relation between the cytopathologic response and HBc gene expression was similar for both cell types, indicating a primary role for HBc gene expression in the cytopathology of HBV-infected human liver. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671703; Yoakum, George H. 1; Korba, Brent E. 2; Lechner, John F. 1; Tokiwa, Takayoshi 3; Gazdar, Adi F. 4; Seeley, Todd; Siegel, Mary 3; Leeman, Lawrence; Autrup, Herman 1; Harris, Curtis C. 5; Affiliations: 1: Senior staff fellow, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 2: Staff fellow, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; 3: Laboratory of Human Carcinogenesis, National Cancer Institute; 4: Deputy branch chief, National Cancer Institute-Navy Medical Oncology Branch; 5: Chief, Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 10/28/1983, Vol. 222 Issue 4622, p585; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schuler, Gerold
AU - Romani, Nikolaus
AU - Linert, Johanna
AU - Shevach, Ethan M.
AU - Stingl, Georg
T1 - Subsets of Epidermal Langerhans Cells as Defined by Lectin Binding Profiles.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/11//
VL - 81
IS - 5
M3 - Article
SP - 397
EP - 402
SN - 0022202X
AB - In this study we characterize the cell surface glycoconjugate moieties of strain 2 guinea pig epidermal Langerhans cells (LC) in single cell suspension by using a battery of 17 fluorescent lectins. All LC displayed binding sites for concanavalin A, succinylated concanavalin A, Lens culinaris agglutinin, Pisum sativum agglutinin, wheat germ agglutinin, succinylated wheat germ agglutinin, Griffonia simplicifolia agglutinin I, Ricinus communis agglutinin I, Phaseolus vulgaris E agglutinin, and Phaseolus vulgaris L agglutinin, but failed to bind Sophora japonica agglutinin (SJA), Dolichos biflorus agglutinin (DBA), and Ulex europaeus agglutinin I (UEA I). Neuraminidase pretreatment rendered LC reactive for SJA, but not for DBA and UEA I. The binding profiles of certain lectins point to the existence of LC subpopulations in that Griffonia simplicifolia I-B4 isolectin, peanut agglutinin (PNA), Helix pomatia agglutinin, and soybean agglutinin bound to only 80% (range 70-90%) of Ia-positive epidermal cells; binding sites for these lectins on primarily unreactive Ia-positive cells were unmasked when epidermal cells were treated with neuraminidase prior to lectin labeling. Ultrastructural PNA labeling studies revealed that the vast majority of Birbeck granule-containing LC displayed PNA binding sites, whereas indeterminate cells were consistently PNA-negative. Identification of carbohydrate configurations expressed on LC surfaces by lectin binding may provide a clue for the elucidation of the mechanisms of established LC functions and possibly the discovery of as yet unknown properties of this cell type. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - LECTINS
KW - RESEARCH
KW - GLYCOCONJUGATES
KW - NEURAMINIDASE
KW - AGGLUTININS
KW - CARBOHYDRATES in the body
N1 - Accession Number: 12521995; Schuler, Gerold 1 Romani, Nikolaus 1 Linert, Johanna 1 Shevach, Ethan M. 2 Stingl, Georg 3; Affiliation: 1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 2: NIAID, National Institutes of Health, Bethesda, Maryland, U.S.A.. 3: Department of Dermatology I, University of Vienna, Vienna, Austria.; Source Info: Nov83, Vol. 81 Issue 5, p397; Subject Term: LANGERHANS cells; Subject Term: LECTINS; Subject Term: RESEARCH; Subject Term: GLYCOCONJUGATES; Subject Term: NEURAMINIDASE; Subject Term: AGGLUTININS; Subject Term: CARBOHYDRATES in the body; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12521995
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Katz, Stephen I.
T1 - Suction Blister Apparatus.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/11//
VL - 81
IS - 5
M3 - Letter
SP - 467
EP - 467
SN - 0022202X
AB - Presents a letter to the editor stating the willingness to share the blueprints of a Suction Blister Apparatus.
KW - LETTERS to the editor
KW - BLUEPRINTS
N1 - Accession Number: 12522678; Katz, Stephen I. 1; Affiliation: 1: Building 10, Room 12N238, National Cancer Institute, Bethesda, Maryland 20205.; Source Info: Nov83, Vol. 81 Issue 5, p467; Subject Term: LETTERS to the editor; Subject Term: BLUEPRINTS; Number of Pages: 1/6p; Document Type: Letter
L3 - 10.1111/1523-1747.ep12522678
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Hagen, Jan L.
AU - Mannino, Fortune V.
AU - McQuaide, Sharon
AU - Istridis, Demetrius
AU - Barnes, John
AU - Crow, Gary A.
AU - Shepard, Fatty
AU - Kloeppel, Dariene A.
T1 - letters.
JO - Social Work
JF - Social Work
Y1 - 1983/11//Nov/Dec83
VL - 28
IS - 6
M3 - Letter
SP - 491
EP - 495
PB - Oxford University Press / USA
SN - 00378046
AB - Presents several letters to the editor. Information regarding the social values; Discussion on the issue of manuscripts of social work; Insight into the sleep therapy.
KW - LETTERS to the editor
KW - SOCIAL values
KW - MANUSCRIPTS
KW - SLEEP therapy
KW - HUMAN services
KW - SOCIAL services
N1 - Accession Number: 5268816; Hagen, Jan L. 1 Mannino, Fortune V. 2 McQuaide, Sharon 3 Istridis, Demetrius 4 Barnes, John 5 Crow, Gary A. 6 Shepard, Fatty 7 Kloeppel, Dariene A. 8; Affiliation: 1: School of Social Work, University of Minnesota, Minneapolis. 2: Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Mental Health Study Center, Adelphi, Maryland. 3: William W. Backus Hospital Norwich, Connecticut. 4: Graduate School of Social Work, Boston College, Chestnut Hill, Massachusetts. 5: School of Social Work, University of Windsor, Windsor, Ontario, Canada. 6: Logan-Champaign Guidance Clinic, Urbana and Bellefontaine, Ohio. 7: Social Service, Beth Israel Hospital Boston, Massachusetts. 8: South Fulton Hospital, East Point, Georgia.; Source Info: Nov/Dec83, Vol. 28 Issue 6, p491; Subject Term: LETTERS to the editor; Subject Term: SOCIAL values; Subject Term: MANUSCRIPTS; Subject Term: SLEEP therapy; Subject Term: HUMAN services; Subject Term: SOCIAL services; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 5p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - VALLERA, DANIEL A.
AU - ASH, ROBERT C.
AU - ZANJANI, ESMAIL D.
AU - KERSEY, JOHN H.
AU - LEBIEN, TUCKER W.
AU - BEVERLEY, PETER C. L.
AU - NEVILLE JR., DAVID M.
AU - YOULE, RICHARD J.
T1 - Anti-T-Cell Reagents for Human Bone Marrow Transplantation: Ricin Linked to Three Monoclonal Antibodies.
JO - Science
JF - Science
Y1 - 1983/11/04/
VL - 222
IS - 4623
M3 - Article
SP - 512
EP - 515
SN - 00368075
AB - Three new reagents that react against human T cells were synthesized by covalently linking the toxin ricin to monoclonal antibodies recognizing differentiation antigens on the surface of T lymphocytes. Each of these immunotoxins selectively inhibited T-cell proliferation when the cells were incubated in the presence of lactose. Multipotent human stem cells were inhibited only at much higher concentrations. Mixtures of all three immunotoxins were more effective than any one alone. These reagents have the potential for preventing graft-versus-host disease in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671775; VALLERA, DANIEL A. 1; ASH, ROBERT C. 2; ZANJANI, ESMAIL D. 2; KERSEY, JOHN H. 3; LEBIEN, TUCKER W. 4; BEVERLEY, PETER C. L. 5; NEVILLE JR., DAVID M. 6; YOULE, RICHARD J. 6; Affiliations: 1: Department of Therapeutic Radiology and Laboratory MedicinelPathology, University of Minnesota, Minneapolis 55455; 2: Veterans Administration, Medical Center, Minneapolis, Minnesota 55406; 3: Department of Laboratory Medicinel Pathology and Pediatrics, University of Minnesota; 4: Department of Laboratory Medicine! Pathology, University of Minnesota; 5: ICRF Human Tumour Immunology Group, University College Hospital Medical School, London, England; 6: Section on Biophysical Chemistry, Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland 20205; Issue Info: 11/ 4/1983, Vol. 222 Issue 4623, p512; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kempner, E. S.
AU - Miller, J. H.
T1 - Radiation Inactivation of Glutamate Dehydrogenase Hexamer: Lack of Energy Transfer Between Subunits.
JO - Science
JF - Science
Y1 - 1983/11/11/
VL - 222
IS - 4624
M3 - Article
SP - 586
EP - 589
SN - 00368075
AB - The effects of ionizing radiation on glutamate dehydrogenase and on fluorescein isothiocyanate-tagged glutamate dehydrogenase were analyzed by target theory. Enzymatic activity, fluorescence, and the survival of the 56,000-dalton monomer subunit were determined on frozen samples irradiated at - 135°C and on lyophilized samples irradiated at either -135°C or +30°C. The effects oftemperature were the samefor all three parameters. Enzymatic activity was lost after small doses of high-energy electrons, whereas fluorescence and monomer subunits survived much larger doses of radiation. Target analysis revealed that the functional unit size for enzymatic activity was the hexamer, confirming both the earlier radiation study and conventional biochemical analyses. Target sizes obtainedfromfluorescence and subunit structure measurements were close to that of the monomer. These results indicate that the primary ionization caused by electron bombardment results in damage to a single polypeptide strand and that there is no massive transfer of radiation energy to other units in the hexamer. The large target size observed for enzymatic activity appears to be a structural requirement for the simultaneous presence ofsix intact subunits rather than the result of the spread ofenergy from the initial site to adjacent chains with consequent damage to other subunits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671790; Kempner, E. S. 1; Miller, J. H. 1; Affiliations: 1: National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205; Issue Info: 11/11/1983, Vol. 222 Issue 4624, p586; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenberg, Martin
AU - Chepelinsky, Ana B.
AU - McKenney, Keith
T1 - Studying Promoters and Terminators by Gene Fusion.
JO - Science
JF - Science
Y1 - 1983/11/18/
VL - 222
IS - 4625
M3 - Article
SP - 734
EP - 739
SN - 00368075
N1 - Accession Number: 84671830; Rosenberg, Martin 1,2; Chepelinsky, Ana B. 3,4; McKenney, Keith 5; Affiliations: 1: Staff, Laboratory'of Biochemistry, National Cancer Institute, Bethesda, Maryland 20205; 2: Director, Department of Molecular Genetics, Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101; 3: Laboratory of Biochemistry, National Cancer Institute; 4: Department of Molecular and Developmental Biology, National Eye Institute, Bethesda 20205; 5: Laboratory of Molecular Biology, Medical Research Council Centre, University Medical School, Cambridge CB2 2QH, England; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p734; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenthal, Nadia
AU - Kress, Michel
AU - Gruss, Peter
AU - Khoury, George
T1 - BK Viral Enhancer Element and a Human Cellular Homolog.
JO - Science
JF - Science
Y1 - 1983/11/18/
VL - 222
IS - 4625
M3 - Article
SP - 749
EP - 755
SN - 00368075
N1 - Accession Number: 84671832; Rosenthal, Nadia 1; Kress, Michel 1; Gruss, Peter 1; Khoury, George 1; Affiliations: 1: Staff members, Laboratory of Molecular Virology, National Cancer Institute, Building 41, Suite 200, Bethesda, Maryland 20205; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p749; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nirenberg, M.
AU - Wilson, S.
AU - Higashida, H.
AU - Rotter, A.
AU - Krueger, K.
AU - Busis, N.
AU - Ray, R.
AU - Kenimer, J. G.
AU - Adler, M.
T1 - Modulation of Synapse Formation by Cyclic Adenosine Monophosphate.
JO - Science
JF - Science
Y1 - 1983/11/18/
VL - 222
IS - 4625
M3 - Article
SP - 794
EP - 799
SN - 00368075
N1 - Accession Number: 84671839; Nirenberg, M. 1; Wilson, S. 1; Higashida, H. 1; Rotter, A. 1; Krueger, K. 1; Busis, N. 1; Ray, R. 1; Kenimer, J. G. 1; Adler, M. 1; Affiliations: 1: Members, Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 36, Room IC-06, Bethesda, Maryland 20205; Issue Info: 11/18/1983, Vol. 222 Issue 4625, p794; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FREED, WILLIAM J:
AU - Ko, GRANT N.
AU - NIEHOFF, DEBRA L.
AU - KUHAR, MICHAEL J.
AU - HOFFER, BARRY J.
AU - OLSON, LARS
AU - CANNON-SPOOR, H. ELEANOR
AU - MORIHISA, JOHN M.
AU - WYATT, RICHARD JED
T1 - Normalization of Spiroperidol Binding in the Denervated Rat Striatum by Homologous Grafts of Substantia Nigra.
JO - Science
JF - Science
Y1 - 1983/11/25/
VL - 222
IS - 4626
M3 - Article
SP - 937
EP - 939
SN - 00368075
AB - Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status ofhost brain cell receptors that is associated with a reduction in the behavioral deficit. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671882; FREED, WILLIAM J: 1; Ko, GRANT N. 1; NIEHOFF, DEBRA L. 2; KUHAR, MICHAEL J. 2; HOFFER, BARRY J. 3; OLSON, LARS 4; CANNON-SPOOR, H. ELEANOR 5; MORIHISA, JOHN M. 5; WYATT, RICHARD JED 5; Affiliations: 1: Preclinical Neurosciences Section, Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032; 2: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 3: Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262; 4: Department of Histology, Karolinska Institute, Stockholm, Sweden; 5: Preclinical Neurosciences Section, Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital; Issue Info: 11/25/1983, Vol. 222 Issue 4626, p937; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zahn-Waxler, Carolyn
AU - Friedman, Sarah L.
AU - Cummings, E. Mark
T1 - Children's Emotions and Behaviors in Response to Infants' Cries.
JO - Child Development
JF - Child Development
Y1 - 1983/12//
VL - 54
IS - 6
M3 - Article
SP - 1522
EP - 1528
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12418532; Zahn-Waxler, Carolyn 1 Friedman, Sarah L. 1 Cummings, E. Mark 1; Affiliation: 1: National Institute of Mental Health.; Source Info: Dec1983, Vol. 54 Issue 6, p1522; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1467-8624.ep12418532
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horowitz, Herschel S.
T1 - Evaluation of the effect of interexaminer reliability in clinical trials of dental caries prevention.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1983/12//
VL - 11
IS - 6
M3 - Article
SP - 384
EP - 385
SN - 03015661
AB - Data from a 3-yr clinical trial were used to assess reliability of two dentists who, without standardizing techniques, independently examined 286 continuous participants. Only 13.1 of 128 tooth surfaces (third molars excluded) showed a change in caries status during the trial by one or both examiners' findings. Although there was poor agreement between the examiners (46.5%) on these changes, they agreed very closely on measuring the cariostatic effects in the various treatment groups because the disagreements were random and were similar among groups. [ABSTRACT FROM AUTHOR]
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KW - DENTAL caries
KW - EPIDEMIOLOGY
KW - CLINICAL trials
KW - DENTISTS
KW - TEETH -- Care & hygiene
KW - DENTAL care
KW - dental caries
KW - epidemiology
KW - oral
KW - reliability.
N1 - Accession Number: 12019241; Horowitz, Herschel S. 1; Affiliation: 1: National Caries Program, National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Dec1983, Vol. 11 Issue 6, p384; Subject Term: DENTAL caries; Subject Term: EPIDEMIOLOGY; Subject Term: CLINICAL trials; Subject Term: DENTISTS; Subject Term: TEETH -- Care & hygiene; Subject Term: DENTAL care; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: oral; Author-Supplied Keyword: reliability.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0528.ep12019241
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murthy, Adavi S. N.
AU - Flavin, Martin
T1 - Microtubule assembly using the microtubule-associated protein MAP-2 prepared in defined stated of phosphorylation with protein kinase and phosphatase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1983/12//12/1/83
VL - 137
IS - 1/2
M3 - Article
SP - 37
EP - 46
PB - Wiley-Blackwell
SN - 00142956
AB - A microtubule-associated protein (the 270-kDa MAP-2) was prepared in two defined stats of phosphorylation by (a) phosphorylation by associated kinase to the extent of ll–14 mol/mol, and (b) removal of 70–80% of this phosphate with a protein phosphatase purified from brain. The newly introduced phosphate was in addition to about 10 mol/mol already present in MAP-2 as isolated; these phosphates were not appreciably released by the phosphatase and did not exchange with ATP. In microtubules assembled with phosphorylated 24 mol/mol) MAP-2 the assembly rate was decreased, microtubule length and critical concentration for assembly were unaffected, and rates of loss of subunits were increased from both microtubule ends. Phosphorylation also reduced the binding of MAP-2 to taxol-stabilized microtubules. These changes were unequivocally due to phosphorylation, sin phosphatase treatment reversed all of them. The brain phosphatase used in the experiments was purified 3000-fold towards histone, but only 100-fold towards MAP-2, suggesting brain may contain another enzyme more specific for MAP+2. Calcineurin, however, had only a low activity for MAP-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - BONE products
KW - PHOSPHOPROTEIN phosphatases
KW - CELL organelles
KW - MICROTUBULES
KW - PROTEIN kinases
KW - PHOSPHATASES
N1 - Accession Number: 13867164; Murthy, Adavi S. N. 1 Flavin, Martin 1; Affiliation: 1: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 12/1/83, Vol. 137 Issue 1/2, p37; Subject Term: RESEARCH; Subject Term: BONE products; Subject Term: PHOSPHOPROTEIN phosphatases; Subject Term: CELL organelles; Subject Term: MICROTUBULES; Subject Term: PROTEIN kinases; Subject Term: PHOSPHATASES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hou, De-Yan
AU - Hoch, Hans
AU - Johnston, Gerald
AU - Tsou, K.
AU - Farkas, Raymond
AU - Miller, Elizabeth
T1 - Stability of In-Bleomycin in vivo -Properties compared with Co-bleomycin.
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
Y1 - 1983/12//
VL - 8
IS - 12
M3 - Article
SP - 535
EP - 540
SN - 03406997
N1 - Accession Number: 71154011; Hou, De-Yan 1 Hoch, Hans 1 Johnston, Gerald 1 Tsou, K. 2 Farkas, Raymond 1 Miller, Elizabeth 2; Affiliation: 1: Department of Nuclear Medicine, National Institutes of Health, Building 10, room 1C401, ACRF 20205 Bethesda USA 2: Harrison Department of Surgical Research, University of Pennsylvania, 19104 Philadelphia USA; Source Info: Dec1983, Vol. 8 Issue 12, p535; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/BF00251616
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ansel, John C.
AU - Luger, Thomas A.
AU - Green, Ira
T1 - The Effect of In Vitro and In Vivo UV Irradiation on the Production of ETAF Activity by Human and Murine Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1983/12//
VL - 81
IS - 6
M3 - Article
SP - 519
EP - 523
SN - 0022202X
AB - Cultured epidermal cells and keratinocytes produce a potent hormone-like factor called epidermal cell-derived thymocyte-activating factor (ETAF). ETAF appears to be similar if not identical to a monocyte-derived lymphokine, known as interleukin 1 (IL-1). These two cytokines are able to amplify a diverse number of proliferative and inflammatory processes. Several recent investigations have suggested that UV-induced immunosuppression may be due in part to the inhibition of IL-1/ETAF production by monocytes and keratinocytes, respectively. We therefore decided to directly study the effects of various doses of in vitro and in vivo UV radiation (UVR) on the production of ETAF by normal murine epidermal cells and a murine (Pam 212) and a human (SCC) keratinocyte cell line. Our results surprisingly demonstrated an increase in both the extracellular and the intracellular ETAF activity of the murine epidermal, Pam 212, and SCC after sublethal amounts of in vitro UVR. Likewise, increased ETAF activity of murine epidermal cells was detected after sublethal doses of in vivo UVR. The UV-induced ETAF activity was cycloheximide-sensitive, suggesting that de novo synthesis of ETAF rather than cell membrane leakage was responsible for the increased ETAF activity. The fact that UV irradiation can increase ETAF activity by keratinocytes could have important local and systemic consequences for the host and may provide an efficient, contaminant-free method for generating ETAF activity for further biochemical and immunologic studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - KERATINOCYTES
KW - CELL culture
KW - IMMUNE response -- Regulation
KW - CYTOKINES
KW - CELLULAR immunity
N1 - Accession Number: 12522862; Ansel, John C. 1 Luger, Thomas A. 2 Green, Ira 1; Affiliation: 1: Laboratory of Immunology, National institute of Allergy and infectious Diseases, National institutes of Health, Bethesda, Maryland, U.S.A. 2: 2nd Department of Dermatology, University of Vienna, Vienna, Austria.; Source Info: Dec83, Vol. 81 Issue 6, p519; Subject Term: CELLS; Subject Term: KERATINOCYTES; Subject Term: CELL culture; Subject Term: IMMUNE response -- Regulation; Subject Term: CYTOKINES; Subject Term: CELLULAR immunity; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12522862
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Qwarnstrom, E.E.
AU - Omnell, K.-A.
AU - Hand, A.R.
T1 - A morphologic study of the recovery of the rat submandibular gland after retrograde infusion.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1983/12//
VL - 12
IS - 6
M3 - Article
SP - 417
EP - 429
SN - 03009777
AB - The recovery of the rat submandibular gland after retrograde infusion of water-soluble radiographic contact medium was studied using an experimental model. During continuous monitoring of the developing intraglandular pressure, the glands were subjected to ducta and slight parenchymal filling or heavy parenchymal filling with the medium. The animals were killed after varying recovery periods, and the tissue was prepared for light and electron microscopic examination. Dilation of the ductal lumina, induced during ductal and slight parenchymal filling, was successively reduced and, generally, the parenchyma had a normal appearance at 30 h. In glands subjected to heavy parenchymal filling, the changes in the intralobular ducts were more pronounced and were also seen at later times after infusion. Alterations in the acini, comprising fusion of secretory granules, vacuole formation and dilation of the acinar lumina and intercellular canaliculi, were observed. At later times, atrophy of the parenchymal cells occurred together with an apparent proliferation of the connective-tissue stroma, as well as an increase in the number of small blood vessels. An inflammatory cell-infiltrate was seen in both groups of animals, but was most prominent in glands subjected to heavy parenchymal filling. The infiltrate, comprised primarily of macrophages and polymorphonuclear leukocytes, reached a peak at 20 h after infusion. At later times, mast cells and occasional eosinophils were seen. The observed alterations and the pattern of recovery are most likely due to the induced intraglandular pressure and the following inflammatory reaction. It is also possible that the changes, to some extent, are influenced by the presence of the contrast medium in the tissue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBMANDIBULAR gland
KW - CONTRAST media (Diagnostic imaging)
KW - MORPHOLOGY
KW - RATS
N1 - Accession Number: 11393058; Qwarnstrom, E.E. 1 Omnell, K.-A. 1 Hand, A.R. 1; Affiliation: 1: Laboratory of Oral Biology and Physiology, National Institute of Dental Research, National Institutes of Health, USA; Source Info: Dec83, Vol. 12 Issue 6, p417; Subject Term: SUBMANDIBULAR gland; Subject Term: CONTRAST media (Diagnostic imaging); Subject Term: MORPHOLOGY; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1600-0714.ep11393058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Magrath, Ian
AU - Erikson, Jan
AU - Whang-Peng, Jacqueline
AU - Sieverts, Hauke
AU - Armstrong, Gary
AU - Benjamin, David
AU - Triche, Timothy
AU - Alabaster, Oliver
AU - Croce, Carlo M.
T1 - Synthesis of Kappa Light Chains by Cell Lines Containing an 8;22 Chromosomal Translocation Derived from a Male Homosexual with Burkitt's Lymphoma.
JO - Science
JF - Science
Y1 - 1983/12/09/
VL - 222
IS - 4628
M3 - Article
SP - 1094
EP - 1098
SN - 00368075
AB - Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence ofimmunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm ofchromosome 8 and a chromosome bearing an immunoglobulin gene, alteration ofcellular myc expression may occur regardless of the immunoglobulin gene that is expressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671938; Magrath, Ian 1; Erikson, Jan 2; Whang-Peng, Jacqueline 3; Sieverts, Hauke 1; Armstrong, Gary 4; Benjamin, David 1; Triche, Timothy 5; Alabaster, Oliver 6; Croce, Carlo M. 2; Affiliations: 1: Pediatric Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3: Medicine Branch, Division of Cancer Treatment, National Cancer Institute; 4: Division of Virology, Office of Biologics, National Center of Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland 20205; 5: Laboratory of Pathology, National Cancer Institute; 6: Division of Hematology/Oncology, George Washington University, Washington, D.C. 20037; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1094; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WHITNALL, MARK H.
AU - GAINER, HAROLD
AU - COX, BRIAN M.
AU - MOLINEAUX, CHRISTOPHER J.
T1 - Dynorphin-A-(1-8) Is Contained Within Vasopressin Neurosecretory Vesicles in Rat Pituitary.
JO - Science
JF - Science
Y1 - 1983/12/09/
VL - 222
IS - 4628
M3 - Article
SP - 1137
EP - 1139
SN - 00368075
AB - Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671964; WHITNALL, MARK H. 1; GAINER, HAROLD 1; COX, BRIAN M. 2; MOLINEAUX, CHRISTOPHER J. 2; Affiliations: 1: Laboratory of Neurochemistry and Neuroimmunology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1137; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DONIGER, J.
AU - Di PAOLO, J. A.
AU - POPESCU, N. C.
T1 - Transformation of Bloom's Syndrome Fibroblasts by DNA Transfection.
JO - Science
JF - Science
Y1 - 1983/12/09/
VL - 222
IS - 4628
M3 - Article
SP - 1144
EP - 1146
SN - 00368075
AB - Nonmalignant diploid humanfibroblast cells (GM3498B) derivedfrom a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude micecharacteristics ofneoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671967; DONIGER, J. 1; Di PAOLO, J. A. 1; POPESCU, N. C. 1; Affiliations: 1: Laboratory of Biology, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1144; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BARE, KEITH
AU - CLARK, JEFF
AU - FINE, ROBERT
AU - HOOVER, CAROL
AU - JACQUEZ, JOHN A.
AU - KONIG, MONIKA
AU - LANDER, MARILYN
AU - MCKINLEY, PAT
AU - O'NEILL, VERONICA
AU - SCHIFFMANN, GENEVIEVE
T1 - The AAAS and Human Rights.
JO - Science
JF - Science
Y1 - 1983/12/16/
VL - 222
IS - 4629
M3 - Article
SP - 1189
EP - 1189
SN - 00368075
N1 - Accession Number: 84671969; BARE, KEITH 1; CLARK, JEFF 1; FINE, ROBERT 1; HOOVER, CAROL 1; JACQUEZ, JOHN A. 1; KONIG, MONIKA 1; LANDER, MARILYN 1; MCKINLEY, PAT 1; O'NEILL, VERONICA 1; SCHIFFMANN, GENEVIEVE 2; Affiliations: 1: National Institutes of Health, Bethesda, Maryland 20205; 2: Medical Scientists Committee, National Institutes of Health, affiliated with Amnesty International; Issue Info: 12/16/1983, Vol. 222 Issue 4629, preceding p1189; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHIMOMURA, KYOICHI
AU - MULLINIX, MARY G.
AU - KAKUNAGA, TAKEO
AU - FUJIKI, HIROTA
AU - SUGIMURA, TAKASHI
T1 - Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxn, a Tumor Promoter.
JO - Science
JF - Science
Y1 - 1983/12/16/
VL - 222
IS - 4629
M3 - Article
SP - 1242
EP - 1244
SN - 00368075
AB - Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding ofphorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671997; SHIMOMURA, KYOICHI 1; MULLINIX, MARY G. 1; KAKUNAGA, TAKEO 1; FUJIKI, HIROTA 2; SUGIMURA, TAKASHI 2; Affiliations: 1: Cell Genetics Section, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 2: National Cancer Center Research Institute, Tokyo, Japan; Issue Info: 12/16/1983, Vol. 222 Issue 4629, p1242; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HEALY, DAVID L.
AU - HODGEN, GARY D.
AU - SCHULTE, HEINRICH M.
AU - CHROUSOS, GEORGE P.
AU - LORIAUX, D. LYNN
AU - HALL, NICHOLAS R.
AU - GOLDSTEIN, ALLAN L.
T1 - The Thymus-Adrenal Connection: Thymosin Has Corticotropin-Releasing Activity in Primates.
JO - Science
JF - Science
Y1 - 1983/12/23/
VL - 222
IS - 4630
M3 - Article
SP - 1353
EP - 1355
SN - 00368075
AB - Endotoxin-free thymosin fraction 5 elevated corticotropin, β-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides ofthymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy ofjuvenile macaques was associated with decreases in plasma cortisol, corticotropin, and β-Iendorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672038; HEALY, DAVID L. 1; HODGEN, GARY D. 1; SCHULTE, HEINRICH M. 2; CHROUSOS, GEORGE P. 2; LORIAUX, D. LYNN 2; HALL, NICHOLAS R. 3; GOLDSTEIN, ALLAN L. 3; Affiliations: 1: Pregnancy Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; 2: Developmental Endocrinology Branch, National Institute of Child Health and Human Development; 3: Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037; Issue Info: 12/23/1983, Vol. 222 Issue 4630, p1353; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-06089-000
AN - 9999-06089-000
AU - Schroeder, David H.
AU - Costa, Paul T. Jr.
T1 - Life Event List
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1984///
AD - Costa, Paul T. Jr., Baltimore City Hospitals, Gerontology Research Center, Section on Stress and Coping, Baltimore, Maryland, United States, 21224
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1 - Accession Number: 9999-06089-000. Partial author list: First Author & Affiliation: Schroeder, David H.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, United States. Release Date: 20111010. Correction Date: 20160808. Instrument Type: Checklist. Test Format: Participants mark each event on the Life Event List that they had experienced during the past year, which was divided into two 6-month periods. For each event marked, they also rate the degree of distress that they experienced on a scale of 0-100 points. The overall event score consists of the total number of events marked for the 12-month period.. Language: English. Constructs: Life Event Stress; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Life Event List is to assess stressful life events.
AB - Description: The Life Event List (Schroeder & Costa, Jr., 1984) was developed to measure stressful life events. This measure was constructed in the course of a study investigating the hypothesis that the reported relationship between life event stress and physical illness is primarily a function of criterion and other content contamination in the stress measure. The Life Event List consists of 87 items and was designed to constitute a reasonably comprehensive, representative counterpart to the lists used in the literature. The first 42 events in the list were taken from the Holmes-Rahe (1967) Schedule of Recent Experience. To these items, 45 events that were drawn from lists used by Paykel et al. (1971); Myers, Lindenthal, and Pepper (1971); B. S. Dohrenwend, Krasnoff, Askenasy, and B. P. Dohrenwend (1978); and Johnson and Sarason (1979) and other items judged to be appropriate to a broad adult population were added. Participants (N = 386) were asked to mark each event on the list that they had experienced during the past year, which was divided into two 6-month periods. For each event marked, they also rated the degree of distress that they experienced on a scale of 0-100 points. The overall event score consisted of the total number of events marked for the 12-month period. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Influence of Stress
KW - Life Event List
KW - Live Event Stress
KW - Physical Illness
KW - Test Development
U5 - Life Event List [Test Development]Influence of life event stress on physical illness: Substantive effects or methodological flaws?. (AN: 1984-23643-001 from PsycINFO) Schroeder, David H.; Costa, Paul T.; Apr, 1984. Source: Journal of Personality and Social Psychology. 46(4), American Psychological Association, US; Apr, 1984; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Location: US; Sample: Adults Ranging in Age from the Early 20s to the 90s Keywords: Influence of Stress; Life Event List; Live Event Stress; Physical Illness; Test Development; Subjects: Experiences (Events); Measurement; Physical Disorders; Psychophysiology; Stress Reactions; Test Construction;
DO - 10.1037/t06089-000
L3 - Partial; Full text; 999906089_partial_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-08111-000
AN - 9999-08111-000
AU - McCrae, Robert R.
T1 - Coping Mechanism Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1984///
AD - McCrae, Robert R., Gerontology Research Center, Section on Stress and Coping, Baltimore City Hospitals, Baltimore, Maryland, United States, 21224
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-08111-000. Partial author list: First Author & Affiliation: McCrae, Robert R.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, Maryland, United States. Release Date: 20120109. Correction Date: 20151109. Instrument Type: Rating Scale. Language: English. Constructs: Coping Mechanisms; Classification: Trauma, Stress, and Coping (7800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Coping Questionnaire is to measure a broad range of coping mechanisms utilized as a result of exposure to a stressful life event categorized as either a loss, a threat, or a challenge.
AB - Description: The Coping Mechanism Questionnaire (McCrae, 1984) was developed in an assessing the influence of losses, threats, and challenges on the choice of coping mechanisms. To develop items for the study, men and women responded to 118 items that described ways of coping with stressors and to indicated which of these they had employed at any time during the course of the stressful event. The first 68 items were taken from Ways of Coping (Folkman & Lazarus, 1980); the last 50 were specifically written to cover the major mechanisms identified in a review of the literature. An examination of both item content and intercorrelations showed that most of the information in the 118 items could be represented by a smaller number of scales. Thirty-four factors had eigenvalues greater than 1, and, after varimax rotation, 28 were used as guides to the creation of scales. Since many items had loadings on several scales, the final scale composition was also guided by rational considerations. The reliability of several scales is low to moderate (alphas ranging from .39 to .83). (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Coping Mechanism Scale
KW - Test Development
KW - Coping Responses
KW - Stressful Events
KW - Faith
KW - Fatalism
KW - Expression of Feelings
U5 - Coping Mechanism Scale [Test Development]Situational determinants of coping responses: Loss, threat, and challenge. (AN: 1984-23131-001 from PsycINFO) McCrae, Robert R.; Apr, 1984. Source: Journal of Personality and Social Psychology. 46(4), American Psychological Association, US; Apr, 1984; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Location: United States; Sample: Baltimore Longitudinal Study of Aging Participants (Ages 21-91) Keywords: Coping Mechanism Scale; Test Development; Coping Responses; Stressful Events; Faith; Fatalism; Expression of Feelings; Subjects: Coping Behavior; Rating Scales; Test Construction;
DO - 10.1037/t08111-000
L3 - Full; Full text; 999908111_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-13546-000
AN - 9999-13546-000
AU - Hamilton, Jean A.
AU - Haier, Richard J.
AU - Buchsbaum, Monte S.
T1 - Boredom Coping Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1984///
AD - Hamilton, Jean A., CRB/DERP/NIMH, Center for Studies of Affective Disorders, Biology of Depression Research Unit, Room 10-C-26, Parklawn Building, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-13546-000. Acronyms: BC. Partial author list: First Author & Affiliation: Hamilton, Jean A.; National Institute of Mental Health, Clinical Neuropharmacology Branch, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: The Boredom Coping Scale is a forced-choice scale; the scores range from 0-10, with high scores suggesting more capacity to cope with boredom and, perhaps, less boredom.. Language: English. Constructs: Boredom Coping; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Boredom Coping Scale is to assess the disposition to restructure one’s perceptions and participation in potentially boring activities so as to decrease boredom.
AB - Description: The Boredom Coping Scale (BC; Hamilton, Haier, & Buchsbaum, 1984) was developed to assess the disposition to restructure one’s perceptions and participation in potentially boring activities so as to decrease boredom. The 10 items for this scale were adapted, in part, from items on Zuckerman’s (1979) subscale called 'Boredom Susceptibility' (ZBS) and the Singer and Antrobus (1970) Imaginal Processes Inventory. The BC is a forced-choice scale with statements pertaining to different contexts or situations; the scores range from 0-10, with high scores suggesting more capacity to cope with boredom and, perhaps, less boredom. In a sample of high school students, Cronbach's coefficient alpha for the BC was .67. Test-retest reliability, based on a 1- to 3-week interval for nursing students, was .64. Construct validity was established by comparison with previously-validated personality tests, real-life measures, and laboratory measures of attention. Boredom coping is associated with a higher percent of time actually spent alone, high continuous performance task measures of attentional capacity, and low Minnesota Multiphasic Personality Inventory and Research Diagnostic Criteria indices of psychopathology. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Boredom Coping Scale
KW - Personality Measures
KW - Test Development
KW - Attentional Control
KW - Psychometric Properties
KW - Intrinsic Enjoyment
U5 - Boredom Coping Scale (BC) [Test Development]Intrinsic Enjoyment and Boredom Coping scales: Validation with personality, evoked potential and attention measures. (AN: 1985-08405-001 from PsycINFO) Hamilton, Jean A.; Haier, Richard J.; Buchsbaum, Monte S.; 1984. Source: Personality and Individual Differences. 5(2), Elsevier Science, Netherlands; 1984; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Community College Students; Nursing Students; High School Students Keywords: Boredom Coping Scale; Personality Measures; Test Development; Attentional Control; Psychometric Properties; Intrinsic Enjoyment; Subjects: Boredom; Coping Behavior; Personality Measures; Test Construction; Test Reliability; Test Validity;
DO - 10.1037/t13546-000
L3 - Full; Full text; 999913546_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-13545-000
AN - 9999-13545-000
AU - Hamilton, Jean A.
AU - Haier, Richard J.
AU - Buchsbaum, Monte S.
T1 - Intrinsic Enjoyment Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1984///
AD - Hamilton, Jean A., CRB/DERP/NIMH, Center for Studies of Affective Disorders, Biology of Depression Research Unit, Room 10-C-26, Parklawn Building, 5600 Fishers Lane, Rockville, Maryland, United States, 20857
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-13545-000. Acronyms: IE. Partial author list: First Author & Affiliation: Hamilton, Jean A.; National Institute of Mental Health, Clinical Neuropharmacology Branch, Bethesda, Maryland, United States. Release Date: 20120813. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: Intrinsic Enjoyment Scale items involve a forced choice between an intrinsic and extrinsic self-characterization of one’s 'likes' or 'feelings' across different situations. Each intrinsic statement receives 1 point so that scores can range from 0-9, with high scores suggesting more intrinsic enjoyment.. Language: English. Constructs: Intrinsic Enjoyment; Classification: Emotional States, Emotional Responses, and Motivation (6000). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Intrinsic Enjoyment Scale is to assess intrinsic enjoyment, characterized by intense involvement, interest and absorbed concentration.
AB - Description: The Intrinsic Enjoyment Scale (IE; Hamilton,Haier, & Buchsbaum, 1984) was developed to assesss intrinsic enjoyment, characterized by intense involvement, interest and absorbed concentration. Using a set of 13 statements derived from Csikszentmihalyi’s work (1975) which were consistently identified as reflecting intrinsic enjoyment by a card-sort method, a set of 9 items were chosen with a forced choice between an intrinsic and extrinsic self-characterization of one’s 'likes' or 'feelings' across different situations. Each intrinsic statement receives 1 point so that scores could range from 0-9, with high scores suggesting more intrinsic enjoyment. In a sample of high school students, Cronbach’s coefficient alpha for the IE was .40. The test-retest reliability for nursing students was 0.68. Construct validity was established by comparison with personality tests, real-life measures, and laboratory measures of attention. Intrinsic enjoyment correlated with intrinsic involvement, the affective experience of potency, concentrating well with ease, high ego development, internal locus of control, lack of boredom susceptibility, attentional change and cortical augmenting. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Intrinsic Enjoyment Scale
KW - Personality Measures
KW - Test Development
KW - Psychometric Properties
U5 - Intrinsic Enjoyment Scale (IE) [Test Development]Intrinsic Enjoyment and Boredom Coping scales: Validation with personality, evoked potential and attention measures. (AN: 1985-08405-001 from PsycINFO) Hamilton, Jean A.; Haier, Richard J.; Buchsbaum, Monte S.; 1984. Source: Personality and Individual Differences. 5(2), Elsevier Science, Netherlands; 1984; Administration: Paper Age Group: Adolescence (13-17 yrs), Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Community College Students; Nursing Students; High School Students Keywords: Intrinsic Enjoyment Scale; Personality Measures; Test Development; Psychometric Properties; Subjects: Personality Measures; Pleasure; Test Construction; Test Reliability; Test Validity;
DO - 10.1037/t13545-000
L3 - Full; Full text; 999913545_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-24372-000
AN - 9999-24372-000
AU - Hunter, Fumiyo Tao
T1 - Authority-Reciprocity Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1984///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-24372-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland, United States. Release Date: 20131111. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Location: Table 1, Page 1094. Test Format: Each procedure item is rated on a 4-point Likert-type scale (1 = hardly ever, 2 = not often, 3 = often, 4 = very often). Each reason item is rated on a 4-point Likert-type scale (1 = not my reason at all, 2 = little like my reason, 3 = close to my reason, 4 = my main reason). Scale scores are computed for each relation as unweighted averages.. Language: English. Constructs: Father Child Relations; Interpersonal Interaction; Mother Child Relations; Peer Relations; Classification: Social, Group, and Interpersonal Relationships (7600); Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Authority-Reciprocity Questionnaire is to assess patterns of socializing interactions in adolescents' relations with mothers, fathers, and friends.
AB - Description: The Authority-Reciprocity Questionnaire (Hunter, 1984) was developed to assess patterns of socializing interactions in adolescents' relations with mothers, fathers, and friends. The interactional patterns are assessed by items describing the other person's behavior in Direct Influence and Social Verification contexts, reasons for the person's attempt at direct influence, and reasons for adolescent's seeking social verification from the person. The items adhere closely to statements spontaneously generated by children and adolescents in previous works. All scales consist of eight items (four procedures and four reasons), except for the Unilateral Social Verification scale, which contains seven items. Each item is rated on a 4-point Likert-type scale. Four scale scores are computed for each relation (mother, father, friend) as unweighted averages from the items a priori designated for Unilateral Direct Influence, Mutual Direct Influence, Unilateral, and Mutual Social Verification scales. In a sample of early, middle, and late adolescents, the internal consistencies (Cronbach's alpha) of the scales ranged from .54-.83. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Unilateral and Mutual Social Verification Scales
KW - Authority-Reciprocity Questionnaire
KW - Test Development
KW - Internal Consistency
KW - Adolescents' Relations with Mothers
KW - Fathers
KW - and Friends
KW - Unilateral and Mutual Direct Influence Scales
U5 - Authority-Reciprocity Questionnaire [Test Development]Socializing procedures in parent–child and friendship relations during adolescence. (AN: 1987-34083-001 from PsycINFO) Hunter, Fumiyo T.; Nov, 1984. Source: Developmental Psychology. 20(6), American Psychological Association, US; Nov, 1984; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Students (Ages 12-20); Location: United States Keywords: Unilateral and Mutual Social Verification Scales; Authority-Reciprocity Questionnaire; Test Development; Internal Consistency; Adolescents' Relations with Mothers, Fathers, and Friends; Unilateral and Mutual Direct Influence Scales; Subjects: Adolescent Development; Family Relations; Peer Relations; Rating Scales; Social Influences; Socialization; Test Construction; Test Reliability;
DO - 10.1037/t24372-000
L3 - Partial; Full text; 999924372_partial_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - GEN
AU - Wyngaarden, J B
T1 - A worldwide problem in medical research
JO - A worldwide problem in medical research
JF - A worldwide problem in medical research
Y1 - 1984///
M3 - Book
AB - The subject of this address, 'A Worldwide Problem in Medical Research' has multiple dimensions, but central to it is the stability of university-based research-stability of financial support for established investigators and for the continuous production of well-trained medical scientists. Book Published by Taylor Graham, United Kingdom, 1984
KW - MEDICINE
KW - Research
KW - United kingdom
KW - Universities
N1 - Accession Number: ISTA2001217; Wyngaarden, J B 1; Affiliations: 1 : National Institutes of Health, Bethesda, MD; Source Info: 1984; Note: Place of Publication: United Kingdom; Note: Update Code: 2000; Subject Term: MEDICINE; Author-Supplied Keyword: Research; Author-Supplied Keyword: United kingdom; Author-Supplied Keyword: Universities; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Binkerd, P.E.
AU - Hendrickx, A.G.
AU - Rice, J.M.
AU - Palmer, A.E.
T1 - Embryonic Development in Erythrocebus patas.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1984/01//
VL - 6
IS - 1
M3 - Article
SP - 15
EP - 29
SN - 02752565
AB - The developmental stages of 12 Erythrocebus patas embryos, ranging in gestational age from 30 to 50 days, is described. The pattern of embryogenesis in E. patas closely parallels the anatomic characteristics of human and other nonhuman primate embryos between stages 12 and 23. However, there is a delay in development in E. patas similar to that observed in human embryos which differs from the macaques and baboons. This temporal difference in the embryonic period is an important factor in the design and analysis of early pregnancy studies in this species. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATAS monkey
KW - EMBRYOS
KW - EMBRYOLOGY
KW - PREGNANCY in animals
KW - DEVELOPMENTAL biology
KW - ANIMAL morphology
KW - MONKEYS
KW - PRIMATES
N1 - Accession Number: 12258513; Binkerd, P.E. 1 Hendrickx, A.G. 1 Rice, J.M. 2 Palmer, A.E. 2; Affiliation: 1: California Primate Research Center, University of California, Davis 2: Laboratory of Comparative Carcinogenesis, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of health, Frederick, Maryland; Source Info: 1984, Vol. 6 Issue 1, p15; Subject Term: PATAS monkey; Subject Term: EMBRYOS; Subject Term: EMBRYOLOGY; Subject Term: PREGNANCY in animals; Subject Term: DEVELOPMENTAL biology; Subject Term: ANIMAL morphology; Subject Term: MONKEYS; Subject Term: PRIMATES; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hartge, Patricia
AU - Cahill, John I.
AU - West, Dee
AU - Hauck, Mary
AU - Austin, Donald
AU - Silverman, Debra
AU - Hoover, Robert
T1 - Design and Methods in a Multi-Center Case-Control Interview Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/01//
VL - 74
IS - 1
M3 - Article
SP - 52
EP - 56
PB - American Public Health Association
SN - 00900036
AB - We conducted a case-control study in ten areas of the United States in which a total of 2,982 bladder cancer patients and 5,782 population controls were interviewed. We employed a variety of existing and new techniques to reduce bias and to monitor the quality of data collected. We review here many of the design elements and field methods that can be generally applied in epidemiologic studies, particularly multi-center interview studies, and explain the reasons for our selection of the methods, instruments, and procedures used. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLADDER cancer
KW - CANCER patients
KW - BLADDER diseases
KW - EPIDEMIOLOGY -- Research
KW - UNITED States
N1 - Accession Number: 4954175; Hartge, Patricia 1 Cahill, John I. 2 West, Dee 3 Hauck, Mary 4 Austin, Donald 4 Silverman, Debra 5 Hoover, Robert 6; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Room 3C 06, 7910 Woodmont Avenue, Bethesda, MD 20205 2: Westat, Inc. 3: University of Utah 4: California Department of Health Services 5: Biometry Branch, NCI 6: Environmental Epidemiology Branch, NCI; Source Info: Jan1984, Vol. 74 Issue 1, p52; Subject Term: BLADDER cancer; Subject Term: CANCER patients; Subject Term: BLADDER diseases; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eaton, William W.
AU - McLeod, Jane
T1 - Consumption of Coffee or Tea and Symptoms of Anxiety.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/01//
VL - 74
IS - 1
M3 - Article
SP - 66
EP - 68
PB - American Public Health Association
SN - 00900036
AB - The relationship of consumption of coffee or tea to self-reported symptoms of anxiety is examined with data from the detailed examination component of the National Center for Health Statistics Health and Nutrition Examination Survey. Among this nationwide sample of 3,854 respondents, there was no significant association between consumption of coffee or tea and symptoms of anxiety. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANXIETY
KW - COFFEE
KW - TEA
KW - STRESS (Psychology)
KW - HEALTH surveys -- United States
KW - UNITED States
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4954182; Eaton, William W. 1 McLeod, Jane 2; Affiliation: 1: Center for Epidemiologic Studies, National Institute of Mental Health. 2: Center for Epidemiologic Studies, National Institute of Mental Health; Source Info: Jan1984, Vol. 74 Issue 1, p66; Subject Term: ANXIETY; Subject Term: COFFEE; Subject Term: TEA; Subject Term: STRESS (Psychology); Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; NAICS/Industry Codes: 111330 Non-citrus fruit and tree nut farming; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311920 Coffee and Tea Manufacturing; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burger, R.
AU - Scher, I.
AU - Sharrow, Susan O.
AU - Shevach, E. M.
T1 - Non-activated guinea-pig T cells and thymocytes express Ia antigens: FACS analysis with alloantibodies and monoclonal antibodies.
JO - Immunology
JF - Immunology
Y1 - 1984/01//
VL - 51
IS - 1
M3 - Article
SP - 93
EP - 102
PB - Wiley-Blackwell
SN - 00192805
AB - Conventional alloantisera and monoclonal antibodies to guinea-pig Ia antigens were used for analysis of Ia expression by guinea-pig T cells and thymocytes. Indirect immunofluorescent staining was performed with alloantisera or with ascitic fluid as a source of monoclonal antibody followed by flow microfluorometry analysis on the fluorescence activated cell sorter. About 80% of normal, non-activated peritoneal exudate T cells, lymph node T cells and thymocytes expressed Ia antigens. These data are therefore in contrast to studies with human or murine T cells where Ia antigens were shown to be expressed predominantly on activated but not on non-activated T cells. All the reactivity of the anti-Ia alloantisera for strain 2 T cells could be removed by absorption with an Ia-bearing B cell leukaemia, EN-L2C, but not by its Ia-negative variant, BZ-L2C. Thus, the Ia determinants identified on T and B cells are probably identical. One monoclonal antibody, 25E3, which had previously been shown by serologic analysis to react exclusively with an alloantigenic determinant of strain 2 Ia antigens displayed an unusual pattern of reactivity in that it clearly stained strain 13 thymocytes, but not mature strain 13 T or B lymphocytes. The significance of this possible expression of inappropriate Ia determinants by thymocytes remains unclear. This phenomenon might be associated with differentiation processes in the thymus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MONOCLONAL antibodies
KW - GLYCOPROTEINS
KW - IMMUNOGENETICS
KW - LYMPH nodes
KW - LYMPHOID tissue
N1 - Accession Number: 13400278; Burger, R. 1 Scher, I. 2 Sharrow, Susan O. 3 Shevach, E. M. 4; Affiliation: 1: Institut für Med. Mikrobiologie, Mainz, West Germany. 2: Naval Medical Research National Cancer Institute, Bethesda. 3: Immunology Branch, National Cancer Institute, Bethesda. 4: Laboratory of Immunology, National institute of Allergy and Infectious Diseases, Bethesda, Maryland. U.S.A.; Source Info: Jan1984, Vol. 51 Issue 1, p93; Subject Term: IMMUNOGLOBULINS; Subject Term: MONOCLONAL antibodies; Subject Term: GLYCOPROTEINS; Subject Term: IMMUNOGENETICS; Subject Term: LYMPH nodes; Subject Term: LYMPHOID tissue; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Yinon
AU - Pfeffer, Jeffrey
T1 - Employment Practices in the Dual Economy.
JO - Industrial Relations
JF - Industrial Relations
Y1 - 1984///Winter84
VL - 23
IS - 1
M3 - Article
PB - Wiley-Blackwell
SN - 00198676
AB - The purpose of this paper is to empirically examine whether or not there are significant associations between an establishment's industrial sector location and a large number of employment practices that have been taken to be defining characteristics of labor market segmentation. This focus helps to move the debate over the usefulness of dual economy theory away from a concern solely with differences in attainment processes (Zucker and Rosenstein, 1981; Tolbert et al., 1980; Beck et al., 1978) towards considering whether there is evidence for differences in employers' labor market behavior across economic sectors. We examine aspects of the relationship between industrial sector and labor market practices by drawing from the literature general and specific hypotheses and then testing these using data from a sample of more than 300 Northern California employers. Our results are mixed. The connections between sectoral location and labor practices are not consistent, and there is no evidence of segmentation into primary and secondary labor markets. These empirical findings seriously challenge dual economy theorists' assertion that the structure of the economy significantly affects labor market processes and is ultimately responsible for the emergence of segmented labor markets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Industrial Relations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LABOR supply
KW - DUAL economy
KW - LABOR market
KW - EMPLOYEE selection
KW - INDUSTRIAL location
KW - MARKET segmentation
KW - ECONOMIC structure
KW - AGRARIAN societies
KW - NORTH Carolina
KW - UNITED States
N1 - Accession Number: 4550665; Cohen, Yinon 1; Pfeffer, Jeffrey 2; Affiliations: 1: Postdoctoral Fellow, National Institute of Mental Health, Organizations Research Training Program, Stanford University; 2: Professional of Organizational Behavior, Graduate School of Business, Stanford University; Issue Info: Winter84, Vol. 23 Issue 1; Thesaurus Term: LABOR supply; Thesaurus Term: DUAL economy; Thesaurus Term: LABOR market; Thesaurus Term: EMPLOYEE selection; Thesaurus Term: INDUSTRIAL location; Thesaurus Term: MARKET segmentation; Thesaurus Term: ECONOMIC structure; Thesaurus Term: AGRARIAN societies; Subject: NORTH Carolina; Subject: UNITED States; NAICS/Industry Codes: 561320 Temporary Help Services; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Roy-Byrne, Peter
AU - Lee-Benner, Karen
AU - Yager, Joel
T1 - Group Therapy for Bulimia.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 1984///Winter1984
VL - 3
IS - 2
M3 - Article
SP - 97
EP - 116
PB - John Wiley & Sons, Inc.
SN - 02763478
N1 - Accession Number: 12071621; Roy-Byrne, Peter 1 Lee-Benner, Karen 2 Yager, Joel 3,4; Affiliation: 1: Medical Staff Fellow, National Institute of Mental Health, Biological Psychiatry Branch 2: Clinical Coordinator,. UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Instittue 3: Professor of Psychiatry, UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Institute 4: Director, UCLA Eating Disorders Clinic, University of California at Los Angeles Neuropsychiatric Institute; Source Info: Winter1984, Vol. 3 Issue 2, p97; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cummings, E. Mark
AU - Zahn-Waxler, Carolyn
AU - Radke-Yarrow, Marian
T1 - DEVELOPMENTAL CHANGES IN CHILDREN'S REACTIONS TO ANGER IN THE HOME.
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1984/01//
VL - 25
IS - 1
M3 - Article
SP - 63
EP - 74
SN - 00219630
AB - Marital disharmony and family tension have repeatedly been associated with antisocial behavior and emotional problems in children. There is evidence that discord within the home may be a more significant factor titan the break-up of the family in the development of deviant behavior. However, researchers have not examined children's responses to specific family episodes indicative of disharmony. Patterns of responding to others' negative emotional interactions may constitute an important link in an analysis of the processes through which conflict in the home impacts upon children.
KW - FAMILIES
KW - ANTISOCIAL personality disorders
KW - EMOTIONAL problems of children
KW - DEVIANT behavior
KW - CHILD psychology
N1 - Accession Number: 12815063; Cummings, E. Mark 1 Zahn-Waxler, Carolyn 1 Radke-Yarrow, Marian 1; Affiliation: 1: National Institute Of Mental Health, Bethesda, MD, U.S.A.; Source Info: Jan1984, Vol. 25 Issue 1, p63; Subject Term: FAMILIES; Subject Term: ANTISOCIAL personality disorders; Subject Term: EMOTIONAL problems of children; Subject Term: DEVIANT behavior; Subject Term: CHILD psychology; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1469-7610.ep12815063
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fine, Jo-David
AU - Breathnach, Stephen M.
AU - Hintner, Helmut
AU - Katz, Stephen I.
T1 - KF-1 Monoclonal Antibody Defines a Specific Basement Membrane Antigen Defect in Dystrophic Forms of Epidermolysis Bullosa.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/01//
VL - 82
IS - 1
M3 - Article
SP - 35
EP - 38
SN - 0022202X
AB - The monoclonal antibody, KF- 1, identifies a noncollagenous constituent of the lamina densa of the basement membrane zone (BMZ) of skin. In order to determine whether this BMZ constituent is affected in epidermolysis bullosa (EB), a mechanobullous skin disease often resulting in marked disfigurement, we have examined skin from patients with various forms of this disease for binding by KF-1 as well as for binding by polyclonal antibodies to laminin, type IV collagen, and bullous pemphigoid antigen, three other known BMZ components of normal skin. In all specimens from patients with simplex and junctional forms of EB, all four antibodies bound normally. In contrast, absent or diminished KF-1 binding was noted in all skin specimens from patients with dystrophic EB; antibodies directed against the other BMZ constituents, however, bound normally. This suggests that KF-1 may play a role in the structural integrity of normal skin and its absence or diminution may be important in the pathogenesis of lesion formation in dystrophic EB. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - MOLECULAR cloning
KW - BASAL lamina
KW - EPIDERMOLYSIS bullosa
KW - ANTIGENS
KW - COLLAGEN
N1 - Accession Number: 12259063; Fine, Jo-David 1 Breathnach, Stephen M. 2 Hintner, Helmut 3 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Visiting Associate of the National Cancer Institute and a Dowling Travelling Fellow of the British Association of Dermatologists. 3: Recipient of a Max Kade Foundation Fellowship.; Source Info: Jan1984, Vol. 82 Issue 1, p35; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: BASAL lamina; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: ANTIGENS; Subject Term: COLLAGEN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12259063
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12259063&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fine, Jo-David
AU - Neises, Gabrielle R.
AU - Katz, Stephen I.
T1 - Immunofluorescence and Immunoelectron Microscopic Studies in Cicatricial Pemphigoid.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/01//
VL - 82
IS - 1
M3 - Article
SP - 39
EP - 43
SN - 0022202X
AB - We have studied various tissues from 10 patients with cicatricial pemphigoid using direct and indirect immunofluorescence, mechanical suction blister induction, and immunoelectron microscopy. In 8 of the 10 patients, direct immunofluorescence of buccal mucosa showed a linear deposition of immunoreactants, IgG and C3 being those most commonly detected. Direct immunofluorescence of skin was positive in only 4 patients. Only 1 patient had a detectable circulating anti-basement membrane zone antibody. Substitution of normal human oral mucosa for adult skin as the tissue substrate for indirect immunofluorescence did not prove useful in the detection of circulating autoantibodies. Immunoelectron microscopy was performed in the skin or mucosa (buccal or ocular) of 6 patients, revealing lamina lucida localization of in vivo-bound immunoreactants. Indirect immunofluorescence studies on mechanically induced suction blisters in skin of 2 patients with in vivo-bound IgG suggest that the lamina lucida antigen involved in cicatricial pemphigoid may be distinct from the bullous pemphigoid antigen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOFLUORESCENCE
KW - ORAL mucosa
KW - AUTOANTIBODIES
KW - IMMUNOGLOBULINS
KW - SKIN diseases
KW - MICROSCOPY
N1 - Accession Number: 12259075; Fine, Jo-David 1 Neises, Gabrielle R. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1984, Vol. 82 Issue 1, p39; Subject Term: IMMUNOFLUORESCENCE; Subject Term: ORAL mucosa; Subject Term: AUTOANTIBODIES; Subject Term: IMMUNOGLOBULINS; Subject Term: SKIN diseases; Subject Term: MICROSCOPY; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12259075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12259075&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Woodley, David T.
AU - Katz, Stephen I.
T1 - Identification and Partial Characterization of Pemphigoid Antigen Extracted from Normal Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/01//
VL - 82
IS - 1
M3 - Article
SP - 108
EP - 111
SN - 0022202X
AB - Antibodies in the sera of patients with the disease bullous pemphigoid define a normal component of the basement membrane of stratified squamous epithelia. Pemphigoid antigen has been shown to be synthesized by mouse and human epidermal cells in culture as an approximately 220 kd protein when reduced. The purpose of this study was to characterize pemphigoid antigen extracted directly from normal human skin and to determine its relationship to the high molecular weight protein found in culture. Suction blister-derived epidermis was extracted with 2% sodium dodecyl sulfate (SDS) and the solubilized proteins were separated, after reduction, by SDS-polyacrylamide gel electrophoresis (PAGE). The separated proteins were electrophoretically transferred to nitrocellulose sheets. Pemphigoid antigen was then specifically identified by immunoperoxidase staining using pemphigoid sera. IgG from 5 different bullous pemphigoid patients bound a band of apparent molecular weight 225 kd. Antibodies from 6 normal sera and 4 pemphigus sera did not bind this molecule. On a lower percentage (4%) polyacrylamide gel the pemphigoid antigen could be resolved as a doublet (two closely spaced bands) in the range of 220-240 kd. When unreduced, the pemphigoid antigen extracted from skin was also detected as a doublet in the 220-240 kd range. This suggests that the two chains are not necessarily disulfide-linked to each other in skin. Newly synthesized pemphigoid antigen immunoprecipitated from extracts of cultured human epidermal cells could also be identified on SDS-PAGE, when reduced, as a doublet in the 220-240 kd range. Taken together these data demonstrate that the pemphigoid antigen can be extracted directly from normal human skin and is a molecule similar in molecular weight to the antigen synthesized in human epidermal cell culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - BASAL lamina
KW - EPITHELIAL cells
KW - PROTEINS
KW - IMMUNOENZYME technique
KW - CELL culture
N1 - Accession Number: 12259224; Stanley, John R. 1,2,3 Woodley, David T. 1,2,3 Katz, Stephen I. 1,2,3; Affiliation: 1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A. 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda, Maryland, U.S.A. 3: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1984, Vol. 82 Issue 1, p108; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: BASAL lamina; Subject Term: EPITHELIAL cells; Subject Term: PROTEINS; Subject Term: IMMUNOENZYME technique; Subject Term: CELL culture; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12259224
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-09719-004
AN - 2005-09719-004
AU - Strauss, John S.
AU - Bowers, Malcolm B. Jr.
AU - Keith, Samuel J.
AU - Bleuler, Manfred
ED - Strauss, John S.
ED - Bowers, Malcolm B. Jr.
ED - Keith, Samuel J.
T1 - What Is Schizophrenia?
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1984///
VL - 10
IS - 1
SP - 8
EP - 10
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Keith, Samuel J., Center for Studies of Schizophrenia, Clinical Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Rm. 10C-18, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09719-004. Partial author list: First Author & Affiliation: Strauss, John S.; Center for Studies of Schizophrenia, Clinical Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Schizophrenia; Symptoms. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1984.
AB - One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth the effort. We hope that presenting these brief discussions on 'what is schizophrenia' by persons who have worked extensively in the field will allow the reader to note areas of overlap and disagreement as well as variations in emphasis. Although no one may yet be able to provide the definitive answer, at least this collection of informed opinions may help clarify the major questions. The essay by Manfred Bleuler is the sixth in this series. Further collections of these statements will be presented in subsequent issues. Readers' responses and comments are cordially invited. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - symptoms
KW - 1984
KW - Schizophrenia
KW - Symptoms
KW - 1984
DO - 10.1093/schbul/10.1.8
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06408-063
AN - 2006-06408-063
AU - Waskow, Irene Elkin
T1 - Helping Relationships: A Single Process?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1984/01//
VL - 29
IS - 1
SP - 72
EP - 73
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06408-063. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waskow, Irene Elkin; Treatment of Depression Collaborative Research Program, Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Assistance (Social Behavior); Clients; Self-Perception. Minor Descriptor: Self-Efficacy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Wills, Thomas Ashby (Ed). Basic Processes in Helping Relationships=New York: Academic Press, 1982. 543 pp. $39.50; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Jan, 1984.
AB - Reviews the book, Basic Processes in Helping Relationships edited by Thomas Ashby Wills (1982). The editor's promise 'to integrate current research on basic psychological processes in helping relationships' goes largely unfulfilled. The organization and content of the individual chapters do not provide such an integration, nor do most of the chapters deal directly with what the editor sees as the major issues to be addressed, that is, the process through which the helper-client relationship actually develops and how it is related to such factors as the client's self-perceptions, expectations for improvement, and general self efficacy and perceived control. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological processes
KW - helper client relationship
KW - helping relationships
KW - clients
KW - self perceptopm
KW - self efficacy
KW - 1984
KW - Assistance (Social Behavior)
KW - Clients
KW - Self-Perception
KW - Self-Efficacy
KW - 1984
U2 - Wills, Thomas Ashby (Ed). (1982); Basic Processes in Helping Relationships; New York: Academic Press, 1982. 543 pp. $39.50
DO - 10.1037/022580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06408-063&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Haseman, J. K.
AU - Crawford, D. D.
AU - Huff, J. E.
AU - Boorman, G. A.
AU - McConnell, E. E.
T1 - Results from 86 two‐year carcinogenicity studies conducted by the national toxicology program.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 621
EP - 639
SN - 00984108
AB - Five categories of evidence of carcinogenicity in rats and mice were used to group interpretative results on 86 chemicals studied in recent carcinogenicity tests carried out by the National Toxicology Program (NTP). Of these studies, 50% (43/86) were regarded as showing carcinogenic effects, 42% (36/86) gave no evidence of carcinogenicity, 6% (5/86) showed equivocal evidence of carcinogenicity, and 2% (2/86) were regarded as inadequate experiments. The liver was the most frequent site of cancer in male and female Fischer‐344 rats and in male and female B6C3F1 mice. Male rats appeared more sensitive than female rats to the induction of neoplasia, while for mice the females seemed more responsive. The routes of administration yielding the highest percentage (80–83%) of positive studies were gavage and inhalation; approximately one‐third of the feed, drinking water, and dermal studies showed carcinogenic effects. In feeding studies, overall survival in dosed and control groups were similar, while the majority of gavage studies showed significantly reduced survival in one or more dosed groups relative to the corresponding controls. The overall percentage of studies showing carcinogenic effects (50%) agrees closely with the rate reported by other investigators for nearly 200 earlier carcinogenicity experiments conducted by the National Cancer Institute. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457095; Haseman, J. K. 1 Crawford, D. D. 2 Huff, J. E. 3 Boorman, G. A. 3 McConnell, E. E. 3; Affiliation: 1: Biometry and Risk Assessment Program, National Institute of Environmental Health Science, P.O. Box 12233, Research Triangle Park, North Carolina, 27709 2: Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 3: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Source Info: Jan1984, Vol. 14 Issue 5/6, p621; Number of Pages: 19p; Document Type: Article
L3 - 10.1080/15287398409530613
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goering, Peter L.
AU - Klaassen, Curtis D.
T1 - Tolerance to cadmium‐induced toxicity depends on presynthesized metallothionein in liver.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 803
EP - 812
SN - 00984108
AB - Tolerance to Cd‐induced toxicity following pretreatment with Cd is well documented, yet the exact mechanism of tolerance and role of metailothionein (MT) remains equivocal. In this study it was determined if the rapid induction of MT following injection of a challenge dose of Cd or the concentration of presynthesized MT induced by Cd pretreatment is more important for development of tolerance by ascertaining (1) whether the rates of synthesis of MT differ following injection of the challenge dose of Cd in control and Cd‐pretreated rats and (2) if a relationship exists between presynthesized hepatic or renal MT and tolerance to Cd‐induced lethality. Rates of hepatic and renal MT synthesis did not differ following injection of a challenge dose of Cd (2.0 mg Cd/kg, iv) in control and Cd‐pretreated (2.0 mg Cd/kg, sc) rats. However, the progressive increase in concentration of MT in liver after Cd pretreatment correlated with the increase in tolerance to a lethal dose of Cd (4.0 mg Cd/kg, iv), as evidenced by a decrease in mortality in pretreated rats. A similar correlation was not observed between kidney MT levels and tolerance. Therefore, it appears that presynthesized MT in liver rather than increased synthesis of MT following injection of a second dose of Cd is responsible for Cd‐induced tolerance. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457110; Goering, Peter L. 1,2 Klaassen, Curtis D. 3; Affiliation: 1: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, 27709 2: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 3: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, 66103; Source Info: Jan1984, Vol. 14 Issue 5/6, p803; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287398409530628
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NAHARRO, GERMAN
AU - ROBBINS, KEITH C.
AU - REDDY, E. PREMKUMAR
T1 - Gene Product of v-fgr onc: Hybrid Protein Containing a Portion of Actin and a Tyrosine-Specific Protein Kinase.
JO - Science
JF - Science
Y1 - 1984/01/06/
VL - 223
IS - 4631
M3 - Article
SP - 63
EP - 66
SN - 00368075
AB - The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, P70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region Of p70ms-fv is closely related to the tyrosinespecific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692056; NAHARRO, GERMAN 1; ROBBINS, KEITH C. 1; REDDY, E. PREMKUMAR 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p63; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ELESPURU, R. K.
AU - GONDA, S. K.
T1 - Activation of Antitumor Agent Gilvocarcins by Visible Light.
JO - Science
JF - Science
Y1 - 1984/01/06/
VL - 223
IS - 4631
M3 - Article
SP - 69
EP - 71
SN - 00368075
AB - Gilvocarcins that are antitumor agents are activated by low doses of visible light to induce bacteriophage lambda in Escherichia coli. This result is dependent on interaction with DNA. Gilvocarcin M, an analog without antitumor activity, failed to induce the prophage after light exposure, thus demonstrating a correlation between photosensitizing and antitumor activities. These results raise several possibilities regarding the mode of action of gilvocarcins as antitumor agents in vivo, involving light or enzymatic activating systems, which could be exploited in human cancer therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692058; ELESPURU, R. K. 1; GONDA, S. K. 1; Affiliations: 1: National Cancer Institute- Frederick Cancer Research Facility, Fermentation Program, Frederick, Maryland 21701; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p69; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BONNER, TOM
AU - O'BRIEN, STEPHEN J.
AU - NASH, WILLIAM G.
AU - RAPP, ULF R.
AU - MORTON, CYNTHIA C.
AU - LEDER, PHILIP
T1 - The Human Homologs of the raf (mil) Oncogene Are Located on Human Chromosomes 3 and 4.
JO - Science
JF - Science
Y1 - 1984/01/06/
VL - 223
IS - 4631
M3 - Article
SP - 71
EP - 74
SN - 00368075
AB - Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692059; BONNER, TOM 1; O'BRIEN, STEPHEN J. 1; NASH, WILLIAM G. 1; RAPP, ULF R. 1; MORTON, CYNTHIA C. 2; LEDER, PHILIP 2; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701; 2: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p71; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GRAVELL, MANETH
AU - LONDON, WILLIAM T.
AU - HOUFF, SIDNEY A.
AU - MADDEN, DAVID L.
AU - DALAKAS, MARINOS C.
AU - SEVER, JOHN L.
AU - OSBORN, KENT G.
AU - MAUL, DONALD H.
AU - HENRICKSON, ROY V.
AU - MARX, PRESTON A.
AU - LERCHE, NICHOLAS W.
AU - PRAHALADA, SRINIVASA
AU - GARDNER, MURRAY B.
T1 - Transmission of Simian Acquired Immunodeficiency Syndrome (SAIDS) with Blood or Filtered Plasma.
JO - Science
JF - Science
Y1 - 1984/01/06/
VL - 223
IS - 4631
M3 - Article
SP - 74
EP - 76
SN - 00368075
AB - Simian acquired immunodeficiency syndrome (SAIDS), a disease clini-cally and pathologically similar to acquired immunodeficiency syndrome in humans, was transmittedfrom diseased rhesus monkeys (Macaca mulatta) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692060; GRAVELL, MANETH 1; LONDON, WILLIAM T. 1; HOUFF, SIDNEY A. 1; MADDEN, DAVID L. 1; DALAKAS, MARINOS C. 1; SEVER, JOHN L. 1; OSBORN, KENT G. 2; MAUL, DONALD H. 2; HENRICKSON, ROY V. 2; MARX, PRESTON A. 2; LERCHE, NICHOLAS W. 2; PRAHALADA, SRINIVASA 2; GARDNER, MURRAY B. 3; Affiliations: 1: Infectious, Diseases Branch, National Institute for Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205; 2: California Primate Research Center, University of California, Davis 95616; 3: Department of Pathology, School of Medicine, University of California, Davis 95616; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p74; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PAUL, S. M.
AU - HAUGER, R. L.
AU - HULIHAN-GIBLIN, B. A.
AU - SKOLNICK, P.
T1 - Analyzing Nonlinear Scatchard Plots.
JO - Science
JF - Science
Y1 - 1984/01/06/
VL - 223
IS - 4631
M3 - Article
SP - 76
EP - 78
SN - 00368075
N1 - Accession Number: 84692061; PAUL, S. M. 1; HAUGER, R. L. 1; HULIHAN-GIBLIN, B. A. 1; SKOLNICK, P. 2; Affiliations: 1: Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20205; 2: Laboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20205; Issue Info: 1/ 6/1984, Vol. 223 Issue 4631, p76; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SRINIVASAN, A.
AU - REDDY, E. PREMKUMAR
AU - DUNN, CLAIRE Y.
AU - AARONSON, STUART A.
T1 - Molecular Dissection of Transcriptional Control Elements Within the Long Terminal Repeat of the Retrovirus.
JO - Science
JF - Science
Y1 - 1984/01/20/
VL - 223
IS - 4633
M3 - Article
SP - 286
EP - 289
SN - 00368075
AB - The' retroviral long -erminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5' LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3' end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672077; SRINIVASAN, A. 1; REDDY, E. PREMKUMAR 1; DUNN, CLAIRE Y. 1; AARONSON, STUART A. 1; Affiliations: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland,0205; Issue Info: 1/20/1984, Vol. 223 Issue 4633, p286; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morin, Michele M.
AU - Pickle, Linda Williams
AU - Mason, Thomas J.
T1 - Geographic Patterns of Ethnic Groups in the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/02//
VL - 74
IS - 2
M3 - Article
SP - 133
EP - 139
PB - American Public Health Association
SN - 00900036
AB - The geographic distributions of 11 major ethnic groups within the United States, based on 1960 census data, are illustrated by computer-generated state economic area maps. The Scandinavian, German, and Russian ethnic groups were similarly concentrated primarily in the North Central region, while the Irish, Polish, Other East European, and South European groups were clustered predominantly in the Northeast. Other ethnic groups had patterns which were different from either of the above. These maps correspond to the atlases of mortality from cancer and other diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POPULATION
KW - ETHNIC groups
KW - DEMOGRAPHIC surveys
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 4952605; Morin, Michele M. 1 Pickle, Linda Williams 1 Mason, Thomas J. 1; Affiliation: 1: Environmental Epidemiology Branch, National Cancer Institute, 3C29 Landow Building, Bethesda, MD 20205; Source Info: Feb1984, Vol. 74 Issue 2, p133; Subject Term: POPULATION; Subject Term: ETHNIC groups; Subject Term: DEMOGRAPHIC surveys; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kessler, Larry G.
T1 - Treated Incidence of Mental Disorders in a Prepaid Group Practice Setting.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/02//
VL - 74
IS - 2
M3 - Article
SP - 152
EP - 154
PB - American Public Health Association
SN - 00900036
AB - We followed a cohort of 7,666 individuals enrolled continuously for five years in a prepaid group practice in Columbia, Maryland. Incidence rates of all diagnosed mental disorders were estimated at approximately 3.7 per cent, lower for adolescents and children (about 3 per cent), higher for adult males aged 20-49 (4.3 per cent), and highest for adult females (5.8 per cent). Diagnoses are primarily for acute mental disorders and show a tendency to recur at fairly high rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD psychiatry
KW - MENTAL illness
KW - HEALTH maintenance organizations
KW - GROUP medical practice
KW - COLUMBIA (Md.)
KW - MARYLAND
N1 - Accession Number: 4953120; Kessler, Larry G. 1; Affiliation: 1: Division of Biometry and Epidemiology, National Institute of Mental Health, Parklawn Building, Room 18C-14, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Feb1984, Vol. 74 Issue 2, p152; Subject Term: CHILD psychiatry; Subject Term: MENTAL illness; Subject Term: HEALTH maintenance organizations; Subject Term: GROUP medical practice; Subject Term: COLUMBIA (Md.); Subject Term: MARYLAND; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06409-034
AN - 2006-06409-034
AU - Shore, Milton F.
T1 - The Ecology of Delinquency.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1984/02//
VL - 29
IS - 2
SP - 145
EP - 146
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06409-034. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shore, Milton F.; Satellite Clinic, Mental Health Study Center, National Institute of Mental Health, Adelphi, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family Therapy; Juvenile Delinquency; Psychopathology. Minor Descriptor: Schools; Social Influences; Social Issues. Classification: Criminal Behavior & Juvenile Delinquency (3236); Group & Family Therapy (3313). Population: Human (10). Reviewed Item: Henggeler, Scott W. (Ed). Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach=Boston: Wright, 1982. 270 pp. $25.00; 1982. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1984.
AB - Reviews the book, Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach edited by Scott W. Henggeler (1982). The editor of the book under review, his colleagues, and a large number of doctoral students have written a series of comprehensive research summaries in the area of adolescent delinquency on such topics as classification, family therapy, the influence of social class, and the effect of different school settings on behavior to show the need for an ecological framework for the topic. In each case they stress the importance of seeing the youths within their social contexts and the interweaving individual, family, and community factors. The major purpose of the book seems to be to make a case for the ecological model as contrasted with an individual psychopathological model, in understanding and treating antisocial behavior. This book also leaves out recent environmental design and urban planning areas and gives only limited attention to issues of social policy in relation to ecology. The book also has an elementary description of the different approaches to family therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent delinquency
KW - adolescent psychopathology
KW - family-ecological systems
KW - social class
KW - family therapy
KW - school settings
KW - 1984
KW - Family Therapy
KW - Juvenile Delinquency
KW - Psychopathology
KW - Schools
KW - Social Influences
KW - Social Issues
KW - 1984
U2 - Henggeler, Scott W. (Ed). (1982); Delinquency and Adolescent Psychopathology: A Family-Ecological Systems Approach; Boston: Wright, 1982. 270 pp. $25.00
DO - 10.1037/022650
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - JOSEPHS, STEVEN F.
AU - Guo, CHAN
AU - RATNER, LEE
AU - WONG-STAAL, FLOSSIE
T1 - Human Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus.
JO - Science
JF - Science
Y1 - 1984/02/03/
VL - 223
IS - 4635
M3 - Article
SP - 487
EP - 491
SN - 00368075
AB - The nucleotide sequences of the six regions within the normal human cellular locus (c-sis) that correspond to the entire transforming region of the simian sarcoma virus (SSV) genome (v-sis) were determined. The regions are bounded by acceptor and donor splice sites and, except for region 6, resemble exons. Region 6 lacks a 3' donor splice site and terminates -5 base pairsfrom the 3' v-sis-helper-viral junction. This is consistent with a model proposing that SSV was generated by recombination between proviral DNA ofsimian sarcoma associated virus andprotosis and that introns were spliced out subsequently from a fused viral-sis messenger RNA. This also suggests that the 3' recombination occurred within an exon of the woolly monkey (Lagotlirix) genome. The open reading frames predicting the v-sis and c-sis gene products coincide with the stop codon ofc-sis located 123 nucleotides into the fifth region of homology. The overall nucleotide homology was 91 percent with substitutions mainly in the third codon positions within the open reading frame and with greatest divergence within the untranslated 3' portion of the sequences. The predicted protein products for v-sis and c-sis are 93 percent homologous. The predicted c-sis gene product is identical in 31 of 31 amino acids to one of the published sequences ofplatelet-derived growth factor. Thus, c-sis encodes one chain of human platelet-derived growth factor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672111; JOSEPHS, STEVEN F. 1; Guo, CHAN 1; RATNER, LEE 1; WONG-STAAL, FLOSSIE 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 2/ 3/1984, Vol. 223 Issue 4635, p487; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simpson, Andrew J. G.
AU - Dame, John B.
AU - Lewis, Fred A.
AU - McCutchan, Thomas F.
T1 - The arrangement of ribosomal RNA genes in Schistosoma mansoni.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/02/15/
VL - 139
IS - 1
M3 - Article
SP - 41
EP - 45
PB - Wiley-Blackwell
SN - 00142956
AB - The two large ribsomal RNA subunits of Schistosoma mansoni are encoded within a 10000-base sequence, which is tandemly repeated in the schistosome genome. Restriction endonuclease digestion with Bam HI cuts the rRNA gene into three fragments, which have been cloned separately in pBR322 and used to constract a physical map of the gene. The sequence encoding the smaller rRNA subunit is about 2000 bases in length and is situated on the 5′ sie of the sequence encoding the larger subunit, which is about 4000 bases. Approximately 4000 bases of the rRNA gene are spacer and do not code for mature rRNA. There are approximately 100 copies of the rRNA gene per haploid genome of which about 10% exhibit length heterogeneity, as judged by the hybridization of the rDNA plasmids to restriction endonuclease digests of genomic DNA. These structural variants appear to contain additional DNA suquences at more than one site within the gene and are polymorphic within the species S. mansoni. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RIBOSOMES
KW - RNA
KW - SCHISTOSOMA mansoni
KW - NUCLEOTIDE sequence
KW - PLASMIDS
KW - GENETIC polymorphisms
KW - GENETICS
N1 - Accession Number: 13867778; Simpson, Andrew J. G. 1 Dame, John B. 2 Lewis, Fred A. 3 McCutchan, Thomas F. 2; Affiliation: 1: Division of Parasitology, National Institute for Medical Research of the Medical Research Council, The Ridgeway, Mill Hill, London, England, NW7 1AA 2: Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institute of Health, 900 Rockville Pike, Bethesda, Maryland, USA 20205 3: Medical Research Institute, Rockville, Maryland, USA 20852; Source Info: 2/15/84, Vol. 139 Issue 1, p41; Subject Term: RIBOSOMES; Subject Term: RNA; Subject Term: SCHISTOSOMA mansoni; Subject Term: NUCLEOTIDE sequence; Subject Term: PLASMIDS; Subject Term: GENETIC polymorphisms; Subject Term: GENETICS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prakash, Chandra
AU - Katial, Albine
AU - Kang, Mohinder S.
AU - Vijay, Iner K.
T1 - Solubilization of mannosyltransferase activities for the biosynthesis of mammary glycoproteins.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/02/15/
VL - 139
IS - 1
M3 - Article
SP - 87
EP - 93
PB - Wiley-Blackwell
SN - 00142956
AB - The microsomal preparation from the lactating bovine mammary tissue was solubilized by treatment with nonionic detergent, NP-40, at a protein/detergent ratio of 1.5:1 and a detergent concentration of 0.5%. Following centrifugation at 147000 × g for 120 rnin, the supernatant fraction was incubated with labeled sugar nucleotides, GDP-Man and UDP-GlcNAc. It was found to synthesize a series of lipid-linked saccharides up to (Man)5- (GlcNAc)2. The solubilized glycosyltransferases retained up to about 60% of the activity after two weeks of storage at 4°C. The biosynthesis of glycolipids was stimulated by a mixture of lipids obtained by extracting the mammary microsomes with CHCl3/CH3OH (2:1). A labeled lipid-linked tetrasaccharide of the structure Man&alpha1→3ManΒ→GlcNAcΒGlcNAc was isolated by labeling baby hamster kidney cells with [2-3H]mannose under conditions of glucose starvation followed by extraction of the cells with CHCl3/CH3OH (2:1) and separation of the lipids by hiigh-performance liquid chromatography. When this lipid-linked tetrasaccharide was incubated with the solubilized bovine mammary microsomes and GDP-Man, it was elongated to a lipid-linked heptasaccharide having the structure Manα1→2Manα1&rar;2Manα1→3(Manα1→6)ManΒ→GlcNAcΒ→GIcNAc. The kinetics of the elongation reaction also revealed the intermediary formation of smaller amounts of lipid-linked pentasaccharide and hexasaccharide. The elongation reaction did not require any divalent metal ion and had a broad pH optimum between 6.8 and 7.6. The lack of inhibition of the elongation reaction by EDTA or amphomycin support earlier studies that GDP-Man rather than mannosylphosphoryldolichol, is the direct donor of mannosyl residues for the biosynthesis of glycolipids up to (Man)5(GlcNAc)2. Mannosylphosphorylretinol was ineffective as rnannosyl donor for the elongation reaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEIN synthesis
KW - ENZYMES
KW - PROTEINS
KW - NUCLEOTIDES
KW - SACCHARIDES
KW - GLYCOSYLTRANSFERASES
KW - GLYCOPROTEINS
N1 - Accession Number: 13868093; Prakash, Chandra 1 Katial, Albine 1 Kang, Mohinder S. 2 Vijay, Iner K. 1; Affiliation: 1: Department of Animal Sciences, University of Maryland, College Park, Maryland, USA 20742 2: Laboratory of Biochemistry and Metabolism, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205; Source Info: 2/15/84, Vol. 139 Issue 1, p87; Subject Term: GLYCOPROTEIN synthesis; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: NUCLEOTIDES; Subject Term: SACCHARIDES; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: GLYCOPROTEINS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KAN, NANCY C.
AU - FLORDELLIS, CHRISTOS S.
AU - MARK, GEORGE E.
AU - DUESBERG, PETER H.
AU - PAPAS, TAKIS S.
T1 - A Common onc Gene Sequence Transduced by Avian Carcinoma Virus MH2 and by Murine Sarcoma Virus 3611.
JO - Science
JF - Science
Y1 - 1984/02/24/
VL - 223
IS - 4638
M3 - Article
SP - 813
EP - 816
SN - 00368075
AB - A common cellular sequence was independently transduced by avian carcinoma virus MH2 (v-mht) and murine sarcoma virus (MSV) 3611 (v-raf). Comparison of the nucleotide sequences of v-mht and v-raf revealed a region of homology that extends over 969 nucleotides. The homology between the corresponding amino acids was about 95 percent with only 19 of 323 amino acids being different. With this example, S of the 19 known different viral onc genes have been observed in viruses of different taxonomic groups. These data indicate that (i) the number of cellular proto-onc genes is limited because, like other viruses of different taxonomic groups, MH2 and MSV3611 have transduced the same onc gene-specific sequences from different cell species and (ii) that specific deletion and linkage of the same proto-onc sequences to different viral vector elements affect the oncogenic potential of the resulting viruses. The difference in transformation capabilities of MH2 and MSV 3611 serves as an example. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84679912; KAN, NANCY C. 1; FLORDELLIS, CHRISTOS S. 1; MARK, GEORGE E. 2; DUESBERG, PETER H. 3; PAPAS, TAKIS S. 4; Affiliations: 1: Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701; 2: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205; 3: Laboratory of Molecular Biology, University of California, Berkeley 94740; 4: Laboratory of Molecular Oncology, National Cancer Institute; Issue Info: 2/24/1984, Vol. 223 Issue 4638, p813; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Adhya, Sankar
T1 - Mobile Genetic Elements (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1984/03//Mar/Apr84
VL - 72
IS - 2
M3 - Book Review
SP - 204
SN - 00030996
AB - Reviews the book 'Mobile Genetic Elements,' edited by James A. Shapiro.
KW - Mobile genetic elements
KW - Nonfiction
KW - Mobile Genetic Elements (Book)
N1 - Accession Number: 11079611; Adhya, Sankar 1; Affiliations: 1: National Cancer Institute; Issue Info: Mar/Apr84, Vol. 72 Issue 2, p204; Thesaurus Term: Mobile genetic elements; Subject Term: Nonfiction; Reviews & Products: Mobile Genetic Elements (Book); Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shock, N. W.
T1 - AGING.
JO - BioScience
JF - BioScience
Y1 - 1984/03//
VL - 34
IS - 3
M3 - Book Review
SP - 188
EP - 188
SN - 00063568
AB - Reviews the book 'Biological Markers of Aging,' by Mitchell E. Roff and Edward L. Schneider.
KW - Aging
KW - Nonfiction
KW - Roff, Mitchell
KW - Schneider, Edward
KW - Biological Markers of Aging (Book)
N1 - Accession Number: 10098323; Shock, N. W. 1; Affiliations: 1: National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, Baltimore, MD 21224; Issue Info: Mar1984, Vol. 34 Issue 3, p188; Subject Term: Aging; Subject Term: Nonfiction; Reviews & Products: Biological Markers of Aging (Book); People: Roff, Mitchell; People: Schneider, Edward; Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 529
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hall, Russell P
AU - Leiserson, William M.
AU - Chused, Thomas M
AU - Lawley, Thomas J
T1 - Characterization of T Lymphocyte and Monocyte Populations in HLA B8/DRw3 Normal Individuals and in Patients with Dermatitis Herpetiformis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/03//
VL - 82
IS - 3
M3 - Article
SP - 231
EP - 234
SN - 0022202X
AB - Normal individuals who possess the HLA B8/DRw3 haplotype as well as patients with dermatitis herpetiformis have been found to have a number of immunologic abnormalities including decreased numbers of E rosette-positive, Fe IgG receptor-bearing lymphocytes (referred to as TG cells), and increased numbers of cells which spontaneously secrete immunoglobulin, HLA B8/DRw3-positive normal individuals also have an increased risk for the development of a number of immunologically mediated diseases. Since many of these findings are suggestive of B-cell hyperreactivity and since TG cells were initially thought to represent a portion of the T suppressor cell network, we have examined the peripheral blood mononuclear (PBM) cell populations of 14 normal HLA B8/DRw3-positive individuals, 14 patients with dermatitis herpetiformis (all of whom were HLA B8/DRw3-positive), and 9 non-HLA B8/DRw3 individuals using flow cytometry and monoclonal antibodies of the OK and Leu series directed against cell surface antigens. Normal HLA B8/DRw3 individuals were found to have a significantly lower percentage of PBM cells that expressed both OKTS and Leu-2a when compared to normal non-HLA B8/DRw3 individuals (p < .05 Student's t-test). When the ratio of T helper cells (OKT4 and Leu-3a) to T suppressor cells (OKT8 and Leu-2a) was calculated for each individual studied, normal HLA B8/DRw3 individuals were found to have a significantly elevated ratio (Leu-3a/Leu-2a = 2.41 ± .16, mean ± SEM) when compared to non-HLA selected individuals (Leu-3a/Leu-2a = 1.73 ± .05) (p < 0.025). In addition, normal HLA B8/DRw3 individuals had decreased numbers of TG cells when compared to normal non-HLA B8/DRw3 individuals (B8/DRw3 = 6.4 ± .74%, non-B8/ DRw3 = 13.2 ± 1.0%, mean ± SEM, p < .01). In order to determine the cell surface marker characteristics of TG cells, purified TG cells from both normal HLA B8/DRw3 individuals and non-HLA B8/DRw3 individuals were studied using the Leu series monoclonal antibodies and OKM1. Good agreement was found in the percentages of cells expressing each cell surface marker between the two groups. In addition, the TG cells were found to be predominately T cells (78% Leu-1-positive), with both T helper cells (40% Leu-3a-positive) and T suppressor cells (30% Leu-2a-positive) present. These results suggest that the suppressor cell activity associated with the TG subset is not due to a depletion of the T helper cell subset, and that the decreased numbers of TG cells in HLA B8/DRw3 individuals is not due to a preferential loss of cells bearing Leu-1, Leu-2a, Leu-3a, or 0KM 1. The significant elevation of the T helper (OKT4, Leu-3a)/T suppressor (OKT8, Leu-2a) ratio in normal HLA B8/DRw3 individuals represents further documentation of immunologic abnormalities present in normal LILA B8/DRw3 individuals. The elevation of this T helper/T suppressor ratio in these otherwise normal individuals may play a role in their increased risk for the development of immunologic diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATITIS herpetiformis
KW - LYMPHOCYTES
KW - MONOCYTES
KW - IMMUNOGLOBULINS
KW - T cells
KW - FLOW cytometry
N1 - Accession Number: 12260103; Hall, Russell P 1 Leiserson, William M. 2 Chused, Thomas M 2 Lawley, Thomas J 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Maryland, U.S.A. 2: Laboratory of Microbiological Immunity, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1984, Vol. 82 Issue 3, p231; Subject Term: DERMATITIS herpetiformis; Subject Term: LYMPHOCYTES; Subject Term: MONOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: T cells; Subject Term: FLOW cytometry; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260103
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - McConnell, E. E.
AU - Lucier, G. W.
AU - Rumbaugh, R. C.
AU - Albro, P. W.
AU - Harvan, D. J.
AU - Hass, J. R.
AU - Harris, M. W.
T1 - Dioxin in Soil: Bioavailability After Ingestion by Rats and Guinea Pigs.
JO - Science
JF - Science
Y1 - 1984/03/09/
VL - 223
IS - 4640
M3 - Report
SP - 1077
EP - 1079
SN - 00368075
AB - This article presents information on a study related to the effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) in soil on rats and guinea pigs. TCDD is a highly toxic compound found as a contaminant in phenoxy acid herbicides, chlorophenols, and other related chemicals, appears highly persistent in soil except when exposed to sunlight. This compound binds tightly to soil and usually remains on or near the soil surface. After a single dose of TCDD, the guinea pigs were observed for 30 days. Necropsies were performed on animals that died during or were killed at the end of the study and selected tissues were examined histopathologically. The brain, thymus, spleen, liver, right kidney, and testicle from animals killed at the end of the study were weighed. A portion of liver was frozen for TCDD analysis, which after extraction was analyzed as described for soil. The clinicopathologic effects in guinea pigs exposed to either TCDD in corn oil or in contaminated soil were comparable. These animals either failed to gain weight or lost weight and died in a severe state of cachexia from 5 to 21 days after exposure.
KW - Tetrachlorodibenzodioxin
KW - Soils
KW - Guinea pigs as laboratory animals
KW - Rats as laboratory animals
KW - Autopsy
KW - Liver
KW - Endocrine glands
KW - Spleen
N1 - Accession Number: 18880125; McConnell, E. E.; Lucier, G. W.; Rumbaugh, R. C. 1; Albro, P. W. 1; Harvan, D. J. 1; Hass, J. R. 1; Harris, M. W. 1; Affiliations: 1: National Institute of Environmental, Health Sciences, Box 12233, Research Triangle Park, North Carolina 27709.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1077; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Soils; Subject Term: Guinea pigs as laboratory animals; Subject Term: Rats as laboratory animals; Subject Term: Autopsy; Subject Term: Liver; Subject Term: Endocrine glands; Subject Term: Spleen; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Report
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DP - EBSCOhost
DB - eih
ER -
TY - RPRT
AU - Marquardt, Hans
AU - Hunkapiller, Michael W.
AU - Hood, Leroy E.
AU - Todaro, George J.
T1 - Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor.
JO - Science
JF - Science
Y1 - 1984/03/09/
VL - 223
IS - 4640
M3 - Report
SP - 1079
EP - 1082
SN - 00368075
AB - This article presents information on the chemical structure of the Rat Transforming Growth Factor Type-1 (rTGF-1). The structure of rTGF-1 and compositional data on the isolated Lys-C peptides are in agreement with the amino acid compositional data on the whole peptide. The proposed primary structure of rTGF-1 is supported by the finding that native rTGF-1 and its synthetic replicate do not differ significantly in their biological activities in vitro. rTGF-1 is a single-chain polypeptide of 50 residues with a calculated molecular weight of 5616. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of this material, of rTGF-1 isolated from Abelson murine leukemia virus-transformed Fischer rat embryo fibroblasts, and of human melanoma-derived hTGF-1 gave an apparent molecular weight of 7400. The discrepancy between molecular weight and mobility is not understood. The previously reported amino acid composition of hTGF-1was based on an assumed molecular weight of 7400, and thus the number of residues per mole was overestimated. However, the amino acid composition of hTGF-1 agrees well with the expected values by assigning a total of 50 residues.
KW - Polyacrylamide
KW - Chemical structure
KW - Transforming growth factors
KW - Biological response modifiers
KW - Peptides
KW - Colloids
KW - Amino acids
KW - Cytokines
N1 - Accession Number: 18880126; Marquardt, Hans 1; Hunkapiller, Michael W. 2; Hood, Leroy E. 3; Todaro, George J. 1; Affiliations: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701.; 2: Applied Biosystems, Foster City, California 94404.; 3: Division of Biology, California Institute of Technology, Pasadena 91125.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1079; Thesaurus Term: Polyacrylamide; Subject Term: Chemical structure; Subject Term: Transforming growth factors; Subject Term: Biological response modifiers; Subject Term: Peptides; Subject Term: Colloids; Subject Term: Amino acids; Subject Term: Cytokines; Number of Pages: 4p; Document Type: Report
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DP - EBSCOhost
DB - eih
ER -
TY - RPRT
AU - Arya, Suresh K.
AU - Wong-Staal, Flossie
AU - Gallo, Robert C.
T1 - T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells.
JO - Science
JF - Science
Y1 - 1984/03/09/
VL - 223
IS - 4640
M3 - Report
SP - 1086
EP - 1087
SN - 00368075
AB - This article presents information on T-cell growth factor genes (TCGF). TCGF is required for the continuous proliferation of specifically activated mature T lymphocytes. Similarly, some neoplastic mature T cells require TCGF for their growth in vitro, although in some cases without the requirement of prior antigen and lectin activation. This is apparently because at least some of these cells already possess TCGF receptors. Some mature T cells infected with human T-cell leukemia-lymphoma virus (HTLV) require TCGF for growth early in culture. Subsequently, many of the HTLV-infected cell lines become independent of exogenously added TCGF. Some of these cell lines constitutively produce and respond to their own TCGF, while other cell lines do not elaborate detectable extra-cellular TCGF. The question thus arises whether the latter cell lines are truly independent of TCGF or produce small quantities of TCGF, sufficient for growth but undetectable by conventional assay procedures. Moreover, it is possible that these HTLV-infected cells produce TCGF that is not externalized and that would not be detected in extracellular medium.
KW - Growth factors
KW - T cells
KW - Genes
KW - Cell culture
KW - Lymphocytes
KW - Cytokines
KW - Cell lines
N1 - Accession Number: 18880129; Arya, Suresh K. 1; Wong-Staal, Flossie 1; Gallo, Robert C. 1; Affiliations: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205.; Issue Info: 3/9/1984, Vol. 223 Issue 4640, p1086; Subject Term: Growth factors; Subject Term: T cells; Subject Term: Genes; Subject Term: Cell culture; Subject Term: Lymphocytes; Subject Term: Cytokines; Subject Term: Cell lines; Number of Pages: 2p; Document Type: Report
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aitken, AlastairA.
AU - Klee, Claude H.
AU - Cohen, Philip
T1 - The structure of the B subunit of calcineurin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/03/15/
VL - 139
IS - 3
M3 - Article
SP - 663
EP - 671
PB - Wiley-Blackwell
SN - 00142956
AB - The complete primary structure of the B subunit of calcineurin (protein phosphatase 213) has been determined by automated sequence analysis. The protein consists of a single polypeptide chain of 168 residues, relative molecular mass 19200. The structure shows 35% identity with the sequence of calmodulin and 29 % with troponin C. Homology is mainly confined to the regions of the four putative Ca2+ .binding loops. The results demonstrate that the B subunit is a new member of this family of Ca2+ -binding proteins. The N-terminal glycine residue is blocked with the C14-saturated fatty acid myristic acid and the first four residues are very similar to those of the catalytic subunit of cyclic-AMP-dependent protein kinase which also contains a myristoyl blocking group. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALMODULIN
KW - PHOSPHOPROTEIN phosphatases
KW - CALCIUM-binding proteins
KW - GLYCINE
KW - PROTEIN kinases
KW - AMINO acid neurotransmitters
N1 - Accession Number: 15818362; Aitken, AlastairA. 1 Klee, Claude H. 1 Cohen, Philip 1; Affiliation: 1: Protein Phosphorylation Group of the Medical Research Council, Department ol Biochemistry. University of Dundee Laboratory of Biochemistry National Cancer Institute,; Source Info: 3/15/84, Vol. 139 Issue 3, p663; Subject Term: CALMODULIN; Subject Term: PHOSPHOPROTEIN phosphatases; Subject Term: CALCIUM-binding proteins; Subject Term: GLYCINE; Subject Term: PROTEIN kinases; Subject Term: AMINO acid neurotransmitters; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MITSUYA, HIROAKI
AU - Guo, HONG-GUANG
AU - MEGSON, MARY
AU - TRAINOR, CECELIA
AU - REITZ JR., MARVIN S.
AU - BRODER, SAMUEL
T1 - Transformation and Cytopathogenic Effect in an Immune Human T-Cell Clone Infected by HTLV-I.
JO - Science
JF - Science
Y1 - 1984/03/23/
VL - 223
IS - 4642
M3 - Article
SP - 1293
EP - 1296
SN - 00368075
AB - Human T-cell leukemia-lymphoma virus (HTLV) is a human C-type retrovirus that can transform T lymphocytes in vitro and is associated with certain T-cell neoplasms. Recent data suggest that, in the United States, patients with acquired immunodeficiency syndrome (AIDS), homosexual men with lymphadenopathy, and hemophiliacs have had significant exposure rates to HTLV, whereas matched and unmatched control American subjects have rarely been exposed to this agent. In the present experiments, T cells specifically reactive against HTLV were propagatedfrom a patient whose HTLV-bearing lymphoma was in remission. The T cells were cloned in the presence of the virus and an HTLV-specific cytotoxic T-cell clone was isolated. This clone was infected and transformed by the virus, with one copy of an HTLV-I provirus being integrated into the genome. This T-cell clone did not exhibit the normal dependence on T-cell growth factor (interleukin-2) and proliferated spontaneously in vitro. Exposure of the clone to HTLV-bearing, autologous tumor cells specifically inhibited its proliferation and resulted in its death. These results may have implications for HTLV-associated inhibition of T-cell responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672147; MITSUYA, HIROAKI 1; Guo, HONG-GUANG 1; MEGSON, MARY 1; TRAINOR, CECELIA 1; REITZ JR., MARVIN S. 1; BRODER, SAMUEL 1; Affiliations: 1: Clinical Oncology Program and Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Issue Info: 3/23/1984, Vol. 223 Issue 4642, p1293; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FISCHINGER, PETER J.
T1 - Advanced Computing.
JO - Science
JF - Science
Y1 - 1984/03/30/
VL - 223
IS - 4643
M3 - Article
SP - 1350
EP - 1350
SN - 00368075
N1 - Accession Number: 84672157; FISCHINGER, PETER J. 1; Affiliations: 1: National Cancer Institute, Building 31, Room 11A19, Bethesda, Maryland 2020S; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1350; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROSENBERG, STEVEN A.
AU - GRIMM, ELIZABETH A.
AU - MCGROGAN, MICHAEL
AU - DOYLE, MICHAEL
AU - KAWASAKI, ERNEST
AU - KOTHS, KIRSTON
AU - MARK, DAVID F.
T1 - Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli.
JO - Science
JF - Science
Y1 - 1984/03/30/
VL - 223
IS - 4643
M3 - Article
SP - 1412
EP - 1415
SN - 00368075
AB - The genefor interleukin-2 was isolatedfrom the Jurkat cell line andfrom normal peripheral blood lymphocytes and, when inserted in Escherichia coli, was expressed at high concentrations. This interleukin-2 was purified to apparent homogeneity and tested for biological activity in a variety of assays in vitro and in vivo. The recombinant lymphokine supports the growth of murine and human interleukin-2 dependent cell lines, enhances the generation of murine and human cytolytic cells in vitro, and generates lymphokine activated killer cells from murine and human lymphocytes. It has a serum half-life of 2 to 3 minutes in the mouse and significantly enhances the generation of cytolytic cells in vivo after alloimmunization. No functional differences between native and the recombinant interleukin-2 molecules have been detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672187; ROSENBERG, STEVEN A. 1; GRIMM, ELIZABETH A. 1; MCGROGAN, MICHAEL 2; DOYLE, MICHAEL 2; KAWASAKI, ERNEST 2; KOTHS, KIRSTON 2; MARK, DAVID F. 2; Affiliations: 1: Surgery Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 2: Cetus Corporation, Emeryville, California 94608; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1412; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DE LANEROLLE, PRIMAL
AU - NISHIKAWA, MASAKATSU
AU - YOST, DAVID A.
AU - ADELSTEIN, ROBERT S.
T1 - Increased Phosphorylation of Myosin Light Chain Kinase After an Increase in Cyclic AMP in Intact Smooth Muscle.
JO - Science
JF - Science
Y1 - 1984/03/30/
VL - 223
IS - 4643
M3 - Article
SP - 1415
EP - 1417
SN - 00368075
AB - The role of cyclic adenosine monophosphate-mediated phosphorylation of myosin light chain kinase in relaxing smooth muscle was examined. The kinase was immunoprecipitated from tissue extracts and the phosphate content was determined. The addition offorskolin to resting or methacholine-contracted muscles resulted in an increase in myosin light chain kinase phosphorylation and a relaxation of contracted muscles. These findings suggest that phosphorylation of myosin light chain kinase is one of the reactions in the process by which cyclic adenosine monophosphate causes relaxation of smooth muscle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672188; DE LANEROLLE, PRIMAL 1; NISHIKAWA, MASAKATSU 1; YOST, DAVID A. 2; ADELSTEIN, ROBERT S. 3; Affiliations: 1: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205; 2: Laboratory of Metabolism, National Heart, Lung, and Blood Institute; 3: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1415; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SACKS, DAVID L.
AU - PERKINS, PETER V.
T1 - Identification of an Infective Stage of Leishmania Promastigotes.
JO - Science
JF - Science
Y1 - 1984/03/30/
VL - 223
IS - 4643
M3 - Article
SP - 1417
EP - 1419
SN - 00368075
AB - Sequential development of Leishmania promastigotes from a noninfective to an infective stage was demonstratedfor promastigotes growing in culture and in the sandfly vector. The generation of an infective stage was found to be growth cycle-dependent and restricted to nondividing organisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672189; SACKS, DAVID L. 1; PERKINS, PETER V. 2; Affiliations: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; 2: Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20012; Issue Info: 3/30/1984, Vol. 223 Issue 4643, p1417; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roitt, I. M.
AU - Pujol-Borrell, R.
AU - Hanafusa, T.
AU - Delves, P. J.
AU - Bottazzo, G. F.
AU - Kohn, L. D.
T1 - Asialoagalactothyroglobulin binds to the surface of human thyroid cells at a site distinct from the 'microsomal' autoantigen.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/04//
VL - 56
IS - 1
M3 - Article
SP - 129
EP - 134
PB - Wiley-Blackwell
SN - 00099104
AB - Human thyroglobulin has been shown for the first time to bind to the surface of cultured human thyroid follicular cells. Binding was only observed with partially glycosylated asialoagalactothyroglobulin, not with the fully glycosylated iodoprotein. The binding site for asialoagalactothyroglobulin in the cell membrane is distinct from membrane associated microsomal/microvilli antigen. Since asialoagalactothyroglobulin bears the autoantigenic determinants of the parent molecule, its ability to bind to the thyroid cell surface suggests a possible role for this protein in the pathogenesis of human thyroiditis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROGLOBULIN
KW - CELL membranes
KW - ANTIGENS
KW - THYROIDITIS
KW - PROTEINS
KW - THYROID diseases
KW - thyroglobulin
KW - thyroid cell
KW - thyroid microsomal antigen
KW - thyroiditis
N1 - Accession Number: 17561485; Roitt, I. M. 1 Pujol-Borrell, R. 1 Hanafusa, T. 1 Delves, P. J. 1 Bottazzo, G. F. 1 Kohn, L. D. 2; Affiliation: 1: Department of Immunology, Middlesex Hospital Medical School, London, UK. 2: Section on Biochemistry of Cell Regulation, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1984, Vol. 56 Issue 1, p129; Subject Term: THYROGLOBULIN; Subject Term: CELL membranes; Subject Term: ANTIGENS; Subject Term: THYROIDITIS; Subject Term: PROTEINS; Subject Term: THYROID diseases; Author-Supplied Keyword: thyroglobulin; Author-Supplied Keyword: thyroid cell; Author-Supplied Keyword: thyroid microsomal antigen; Author-Supplied Keyword: thyroiditis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Henderson, W.R.
AU - Harley, J.B.
AU - Fauci, A.S.
T1 - Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.
JO - Immunology
JF - Immunology
Y1 - 1984/04//
VL - 51
IS - 4
M3 - Article
SP - 679
EP - 686
PB - Wiley-Blackwell
SN - 00192805
AB - The formation of 5- and 15-lipoxygenase products of arachidonic acid metabolism was examined in human peripheral blood eosinophils obtained from five normal individuals and five patients with the hypereosinophilic syndrome (HES). Normal and HES eosinophils after stimulation with the calcium ionophore A23187 produced in comparable amounts leukotriene (LT)C4, LTD4, LTB4 and two of its isomers (5-(S),12-(R)-6-trans-LTB4 and 5-(S), 12-(S)-6-trans-LTB4), 15-hydroxy-eicosatetraenoic acid (HETE), 5,15-di-HETE and 8,15-di-HETE. No single lipoxygenase product predominated in the absence of added arachidonic acid whereas 15-HETE was the major product formed when either normal or HES eosinophils were stimulated with A23187 in the presence of added arachidonic acid (10-4 M). [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARACHIDONIC acid
KW - EOSINOPHILS
KW - IONOPHORES
KW - LEUKOTRIENES
KW - LIPOXYGENASES
KW - SYNDROMES
N1 - Accession Number: 13384915; Henderson, W.R. 1 Harley, J.B. 2 Fauci, A.S. 2; Affiliation: 1: Department of Medicine, University of Washington School of Medicine, Seattle, Washington 2: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr84, Vol. 51 Issue 4, p679; Subject Term: ARACHIDONIC acid; Subject Term: EOSINOPHILS; Subject Term: IONOPHORES; Subject Term: LEUKOTRIENES; Subject Term: LIPOXYGENASES; Subject Term: SYNDROMES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thivolet, Charles H.
AU - Hintner, Helmut H.
AU - Stanley, John R.
T1 - The Effect of Retinoic Acid on the Expression of Pemphigus and Pemphigoid Antigens in Cultured Human Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/04//
VL - 82
IS - 4
M3 - Article
SP - 329
EP - 334
SN - 0022202X
AB - Vitamin A and its derivatives (retinoids) have both profound effects on epidermal differentiation and beneficial therapeutic effects in various dermatologic diseases. In order to understand these effects, much work has been done with cultured keratinocytes, which show specific morphologic, cellular, and biochemical changes modulated by retinoids. In an attempt to further define specific molecular effects of retinoids in cultured human keratinocytes, we studied the expression of pemphigus (P) and pemphigoid (BP) antigens by human keratinocytes cultured with retinoic acid (RA) in concentrations which modulated differentiation. Cultures of human keratinocytes in medium with 10% delipidized fetal bovine serum (vitamin A-depleted medium) demonstrated areas of extensive differentiation with flattened stratifying cells, keratohyaline granules, and an anucleate stratum corneum-like superficial layer. These cells also synthesized a 67 kd keratin, characteristic of well-differentiated epidermis. In contrast, cultures of human keratinocytes in the same medium supplemented with (10-7 M, 3 × 10-7 M, or 10-6 M) RA demonstrated less differentiated small cuboidal cells that were stratified but did not form an anucleate layer or keratohyaline granules, and did not synthesize the 67 kd keratin. In order to detect P and BP antigens in these cultures, we used indirect immunofluorescence. In vitamin A-depleted cultures, P antigen either was not dectected or was seen focally on the cell surface of basal cells. BP antigen was seen on the basal pole of the basal cells, approximating its in vivo location. In RA-treated cells, P antigen was seen on the cell surface of most of the cells, and BP antigen was seen throughout the cytoplasm of the basal cells. In order to study the expression of newly synthesized antigens, we radiolabeled cultures with 14C-amino acids and quantitatively immunoprecipitated the antigens, which were then identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis. We detected a major decrease in newly synthesized P antigen precipitated from extracts of vitamin A-depleted cells compared to RA-supplemented cells, whereas amounts of newly synthesized BP antigen were about the same. Taken together these data demonstrate that RA, at concentrations that decrease differentiation of cultures human keratinocytes, increases the expression of P antigen and changes the subcellular location of BP antigen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRETINOIN
KW - PEMPHIGUS
KW - ANTIGENS
KW - KERATINOCYTES
KW - RETINOIDS
KW - EPIDERMIS
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 12260634; Thivolet, Charles H. 1,2 Hintner, Helmut H. 1,2 Stanley, John R. 1,2; Affiliation: 1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A. 2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr84, Vol. 82 Issue 4, p329; Subject Term: TRETINOIN; Subject Term: PEMPHIGUS; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260634
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06411-014
AN - 2006-06411-014
AU - Levy, Sandra M.
T1 - Distress, Coping, and Cancer: The Search for Evidence.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1984/04//
VL - 29
IS - 4
SP - 297
EP - 299
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06411-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Levy, Sandra M.; Behavioral Medicine Branch, National Cancer Institute, National Institutes of Health, Silver Spring, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Animal Ethology; Central Nervous System; Neoplasms; Stress. Minor Descriptor: Rats. Classification: Cancer (3293). Population: Human (10). Reviewed Item: Bammer, Kurt (Ed); Newberry, Benjamin H. (Ed). Stress and Cancer=Toronto, Canada: C. J. Hogrefe, 1981. 264 pp. $19.00; 1981. References Available: Y. Page Count: 3. Issue Publication Date: Apr, 1984.
AB - Reviews the book, Stress and Cancer edited by Kurt Bammer and Benjamin H. Newberry (1981). The purpose of the book includes presenting the perspectives of a variety of workers in the stress-cancer field and related areas without imposing editorial constraints. The purpose is worthy, the product is mixed at best and, on the whole, somewhat disappointing. The range of coverage extends from a specific focus on mammary cancers in rat and mouse models, to meteorological stress and cancer, to a wide-ranging attempt to link the central nervous system with neoplasia. The book is unique in focusing almost exclusively on experimental, laboratory research findings related to behavioral influence on neoplastic development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - stress
KW - cancer
KW - central nervous system
KW - neoplasia
KW - animal ethology
KW - human
KW - 1984
KW - Animal Ethology
KW - Central Nervous System
KW - Neoplasms
KW - Stress
KW - Rats
KW - 1984
U2 - Bammer, Kurt (Ed); Newberry, Benjamin H. (Ed). (1981); Stress and Cancer; Toronto, Canada: C. J. Hogrefe, 1981. 264 pp. $19.00
DO - 10.1037/022778
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KLEIN, DAVID C.
T1 - Melatonin and Puberty.
JO - Science
JF - Science
Y1 - 1984/04/06/
VL - 224
IS - 4644
M3 - Article
SP - 6
EP - 6
SN - 00368075
N1 - Accession Number: 84672199; KLEIN, DAVID C. 1; Affiliations: 1: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20205; Issue Info: 4/ 6/1984, Vol. 224 Issue 4644, p6; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FAHEY, ROBERT C.
AU - NEWTON, GERALD L.
AU - ARRICK, BRADLEY
AU - OVERDANK-BOGART, TOBIE
AU - ALEY, STEPHEN B.
T1 - Entamoeba histolytica: A Eukaryote Without Glutathione Metabolism.
JO - Science
JF - Science
Y1 - 1984/04/06/
VL - 224
IS - 4644
M3 - Article
SP - 70
EP - 72
SN - 00368075
AB - Entamoeba histolytica was found to grow normally without producing glutathione and the main enzymes of glutathione metabolism, indicating that glutathione is not essentialfor many eukaryotic processes. This parasitic amoeba is an unusual eukaryote whose specialfeatures may help define the crucialfunctions of glutathione in those eukaryotes that do use it. Since Entamoeba histolytica lacks mitochondria and the usual aerobic respiratory pathways, the finding that it grows without glutathione and other evidence support the hypothesis that a primary function of glutathione in eukaryotes involves protection against oxygen toxicity associated with mitochondria and suggest that eukaryotes may have acquired glutathione metabolism at the time that they acquired mitochondria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84672240; FAHEY, ROBERT C. 1; NEWTON, GERALD L. 1; ARRICK, BRADLEY 2; OVERDANK-BOGART, TOBIE 2; ALEY, STEPHEN B. 2,3; Affiliations: 1: Department of Chemistry, University of California, San Diego, La Jolla 92093; 2: Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021; 3: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20205; Issue Info: 4/ 6/1984, Vol. 224 Issue 4644, p70; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tardif, Suzette D.
AU - Richter, Conrad B.
AU - Carson, Robert L.
T1 - Effects of Sibling-Rearing Experience on Future Reproductive Success in Two Species of Callitrichidae.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1984/05//
VL - 6
IS - 4
M3 - Article
SP - 377
EP - 380
SN - 02752565
AB - The survival rate for offspring of mothers who either had or did not have previous experience rearing younger siblings was compared in two callitrichid species, Callithrix jacchus and Saguinus oedipus. Offspring of mothers with sibling-rearing experience had a higher survival percentage than offspring of inexperienced mothers in both species. While 50–60% of offspring of inexperienced C jacchus mothers survived, no offspring of inexperienced S. oedipus mothers survived. The results suggest that sibling-rearing experience is necessary for adequate maternal behavior in S. oedipus, but not necessary to the development of maternal behavior in C. jacchus. Effects of previous sibling-rearing experience of S. oedipus fathers on offspring survival were also examined. Whether the father had rearing experience was not related to the survival of their offspring. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL breeding
KW - SURVIVAL analysis (Biometry)
KW - CHILD rearing
KW - COTTONTOP tamarin
KW - CALLITHRIX jacchus
KW - ANIMAL behavior
KW - SURVIVAL behavior (Animals)
KW - ANIMAL psychology
KW - PRIMATES
N1 - Accession Number: 12264888; Tardif, Suzette D. 1 Richter, Conrad B. 2 Carson, Robert L. 1; Affiliation: 1: Marmoset Research Center, Oak Ridge Associated Universities, Oak Ridge, Tennessee 2: National Institute of Environmental Health Sciences; Source Info: 1984, Vol. 6 Issue 4, p377; Subject Term: ANIMAL breeding; Subject Term: SURVIVAL analysis (Biometry); Subject Term: CHILD rearing; Subject Term: COTTONTOP tamarin; Subject Term: CALLITHRIX jacchus; Subject Term: ANIMAL behavior; Subject Term: SURVIVAL behavior (Animals); Subject Term: ANIMAL psychology; Subject Term: PRIMATES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 115210 Support Activities for Animal Production; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Ringen, Knut
T1 - Notification of Workers at High Risk An Emerging Public Health Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/05//
VL - 74
IS - 5
M3 - Article
SP - 485
EP - 491
PB - American Public Health Association
SN - 00900036
AB - During the last two decades, an increasing number of epidemiologic studies have found cohorts of workers to be at high risk or work-related chronic diseases, especially cancers. These studies frequently have led to the broad recognition of occupational hazards and eventually to the prevention of exposures to such hazards. Generally, however, the individual cohort members found to be at high risk have not been notified of study results, and programs of medical intervention or of palliative services directed at these individual workers have not been developed. Recently, the issue of whether or not workers have a right to be notified more directly about know health hazards to which they may have been exposed has emerged as a major, unresolved question in public health policy. Issues of concern include the criteria that should guide notifications; whom, when, and how to notify; and who should pay for notification and follow-up services. This commentary discusses the scientific, ethical, economic, and institutional aspects of worker notification, and describes three new demonstration projects that have provided notification and intervention for workers at high risk of bladder, colon, and lung cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL hazards
KW - OCCUPATIONAL health services
KW - PUBLIC health
KW - MEDICAL policy
KW - MEDICAL care
N1 - Accession Number: 4958846; Schulte, Paul A. 1 Ringen, Knut 2; Affiliation: 1: Epidemiologist, Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226 2: National Cancer Institute, Division of Resources, Center and Community Activities, Bethesda, MD; Source Info: May84, Vol. 74 Issue 5, p485; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL hazards; Subject Term: OCCUPATIONAL health services; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: MEDICAL care; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoflerth, Sandra L.
T1 - LONG-TERM ECONOMIC CONSEQUENCES FOR WOMEN OF DELAYED CHILDBEARING AND REDUCED FAMILY SIZE.
JO - Demography
JF - Demography
Y1 - 1984/05//
VL - 21
IS - 2
M3 - Article
SP - 141
EP - 156
SN - 00703370
AB - Using data from the Panel Study of Income Dynamics, this study explored the association among delayed childbearing, completed family size and several measures of the economic well-being of women age 60 and older in 1976. By retirement age women who bore their first child at age 30 or older are significantly better off economically than either average-age childbearers or the childless. Economic well-being also appears to be related to family size among late childbearers. At retirement age the delayed childbearer with only one or two children appears better off than all other women. Thus, late childbearing and small family size appear associated with the highest standard of living for these women. This study also relates the experience of this early cohort of women to that of more recent birth cohorts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INCOME
KW - FAMILY size
KW - PANEL analysis
KW - WOMEN
KW - BIRTH intervals
KW - NUCLEAR families
N1 - Accession Number: 16799490; Hoflerth, Sandra L. 1; Affiliations: 1: Center for Population Research, National Institute of Child Health and Human Development; Issue Info: May1984, Vol. 21 Issue 2, p141; Thesaurus Term: INCOME; Subject Term: FAMILY size; Subject Term: PANEL analysis; Subject Term: WOMEN; Subject Term: BIRTH intervals; Subject Term: NUCLEAR families; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Bennett, Peter H.
AU - Davidson, Mayer B.
T1 - Diabetes in the elderly: Diagnosis and epidemiology.
JO - Geriatrics
JF - Geriatrics
Y1 - 1984/05//
VL - 39
IS - 5
M3 - Article
SP - 37
EP - 41
SN - 0016867X
N1 - Accession Number: 18145284; Bennett, Peter H. 1; Davidson, Mayer B.; Source Information: May1984, Vol. 39 Issue 5, p37; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2712
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Saxena, Queen B.
AU - Saxena, R. K.
AU - Adler, W. H.
T1 - Effect of feeding a diet with half of the recommended levels of all vitamins on the natural and inducible levels of cytotoxic activity in mouse spleen cells.
JO - Immunology
JF - Immunology
Y1 - 1984/05//
VL - 52
IS - 1
M3 - Article
SP - 41
EP - 48
PB - Wiley-Blackwell
SN - 00192805
AB - Groups of 6-week-old female C57B1/6 mice were fed a normal diet with recommended levels of all vitamins Dr a vitamin-deficient (VD) diet containing half of the recommended level of each vitamin. At different time periods (1-11 weeks) after the initiation of diets, basal natural killer (NK) activity, interleukin-2 (IL-2) and concanavalin A (Con A)-induced cytotoxic activity, Con A-induced IL-2 production and levels of allospecific cytotoxic T cell activity generated in a mixed lymphocyte culture (MLC), were studied in spleen cells derived from control and VD mice. Results indicated that: (i) spleen NK activity remained normal until 2 weeks after the initiation of VD diet, fell steeply to tow levels at the 4 and 5 week time points and remained depressed thereafter; (ii) IL-2- and Con A-induced levels of cytotoxic activity in spleen cells derived from VD mice declined at 4 weeks alter the institution of VD diet, and then remained low throughout the study; (iii) the capacity of spleen cells from VD mice to generate IL-2 in response to Con A and cytotoxic T cells in response to allogeneic spleen cells, was normal at 1 and 4 weeks alter initiation of the VD diet and was markedly depressed at the 6 and 9 week time points. These results suggest that partial combined deficiencies of dietary vitamins strongly influence assays of immune function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMINS
KW - KILLER cells
KW - CELL-mediated cytotoxicity
KW - T cells
KW - SPLEEN
KW - INTERLEUKIN-2
KW - MICE
N1 - Accession Number: 13506325; Saxena, Queen B. 1 Saxena, R. K. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute of Aging, National Institutes of Health, Baltimore, Maryland, U.S.A.; Source Info: May84, Vol. 52 Issue 1, p41; Subject Term: VITAMINS; Subject Term: KILLER cells; Subject Term: CELL-mediated cytotoxicity; Subject Term: T cells; Subject Term: SPLEEN; Subject Term: INTERLEUKIN-2; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Van Houte, A. J.
AU - Inman, J. K.
AU - Lizzio, Elaine F.
AU - Merchant, B.
T1 - Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.
JO - Immunology
JF - Immunology
Y1 - 1984/05//
VL - 52
IS - 1
M3 - Article
SP - 87
EP - 96
PB - Wiley-Blackwell
SN - 00192805
AB - CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N × C3H/HeN F1 male > CBA/N female > CBA/N · C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - B cells
KW - ANTIGENS
KW - IMMUNE response
KW - THYMUS
KW - CELL populations
KW - MICE
N1 - Accession Number: 13506619; Snippe, H. 1 Van Houte, A. J. 1 Inman, J. K. 2 Lizzio, Elaine F. 3 Merchant, B. 3; Affiliation: 1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. 3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: May84, Vol. 52 Issue 1, p87; Subject Term: HAPTENS; Subject Term: B cells; Subject Term: ANTIGENS; Subject Term: IMMUNE response; Subject Term: THYMUS; Subject Term: CELL populations; Subject Term: MICE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Said, Jonathan W.
AU - Sassoon, Aaron F.
AU - Shintaku, I. Peter
AU - Banks-Schlegel, Susan
T1 - Involucrin in Squamous and Basal cell Carcinomas of the Skin: An Immunohistochemical Study.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/05//
VL - 82
IS - 5
M3 - Article
SP - 449
EP - 452
SN - 0022202X
AB - Involucrin is a precursor of the cross-linked envelope protein of human stratum corneum, and its appearance in the upper layers of the epidermis is a function of the normal differentiation of the keratinocyte. Cases of basal cell and squamous cell carcinoma were evaluated for the presence of involucrin using immunoperoxidase techniques on paraffin sections. Basal cell carcinomas were negative for involucrin with staining restricted to squamous horn cysts, while squamous cell carcinomas stained strongly, particularly in large keratinized cells. Cases of squamous cell carcinoma in situ (Bowen's disease) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium. Abnormal patterns of staining were also noted in non-neoplastic epidermis adjacent to carcinomas. Immunohistochemical staining for involucrin identifying abnormal or premature keratinization is a sensitive marker for dyskeratosis in squamous epithelia and may have applications in the histopathologic evaluation of skin specimens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Cancer
KW - BASAL cell carcinoma
KW - SQUAMOUS cell carcinoma
KW - IMMUNOHISTOCHEMISTRY
KW - PROTEIN precursors
KW - KERATINOCYTES
KW - EPIDERMIS
N1 - Accession Number: 12260937; Said, Jonathan W. 1 Sassoon, Aaron F. 2 Shintaku, I. Peter 1 Banks-Schlegel, Susan 3; Affiliation: 1: Division of Anatomic Pathology, Cedars-Sinai Medical Center, Los Angeles, California. 2: Department of Biology, University of Southern California, Los Angeles, California, U. S. A.. 3: Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Source Info: May84, Vol. 82 Issue 5, p449; Subject Term: SKIN -- Cancer; Subject Term: BASAL cell carcinoma; Subject Term: SQUAMOUS cell carcinoma; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: PROTEIN precursors; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260937
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Otsuka, Fujio
AU - Tarone, Robert E.
AU - Cayeux, Sophie
AU - Robbins, Jay H.
T1 - Use of Lymphoblastoid Cell Lines to Evaluate the Hypersensitivity to Ultraviolet Radiation in Cockayne Syndrome.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/05//
VL - 82
IS - 5
M3 - Article
SP - 480
EP - 484
SN - 0022202X
AB - Cockayne syndrome (CS) is a rare autosomal recessive disease characterized by acute sun sensitivity, cachectic dwarfism, and neurologic and skeletal abnormalities. Cultured skin fibroblasts from patients with this disease are known to be hypersensitive to the lethal effects of 254-nm UV radiation. We have studied the sensitivity to 254-nm UV radiation of lymphoblastoid lines derived from 3 typical CS patients, 1 atypical CS patient who had a very late age of onset of clinical manifestations, 2 patients who had both xeroderma pigmentosum (XP) and typical CS, and 3 heterozygous parents of these patients. Post-UV survival was determined by the trypan-blue dye-exclusion method. The lymphoblastoid lines from the 3 typical CS patients, the atypical CS patient, and the 2 patients with both CS and XP had decreased post-UV viability in comparison with lines from normal donors. Lines from the heterozygous parents had normal post-UV viability. The post-UV viability of the typical CS lines was similar to that of a XP complementation group C line. The relative post-UV viability of lymphoblastoid lines from the typical CS patients was similar to the relative post-UV survival of their fibroblast lines. The lymphoblastoid line from the atypical CS patient had a post-UV viability similar to that of the typical CS patients. Thus, the relative hypersensitivity of CS patients' cells in vitro does not reflect the severity or age of onset of the patients' clinical manifestations. The lymphoblastoid lines from the 2 patients who had both CS and XP were significantly more sensitive to the UV radiation than those from patients with only CS. Our studies demonstrate that lymphoblastoid lines from patients with CS are appropriate and useful cell lines for the study of the inherited hypersensitivity to UV radiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOBLASTOID cell lines
KW - CELL culture
KW - ULTRAVIOLET radiation -- Physiological effect
KW - SYNDROMES
KW - ALLERGY
KW - IMMUNOLOGIC diseases
N1 - Accession Number: 12260999; Otsuka, Fujio 1,2 Tarone, Robert E. 1 Cayeux, Sophie Robbins, Jay H. 1; Affiliation: 1: Dermatology Branch and Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2: Department of Dermatology, University of Tokyo, Tokyo, 113, Japan.; Source Info: May84, Vol. 82 Issue 5, p480; Subject Term: LYMPHOBLASTOID cell lines; Subject Term: CELL culture; Subject Term: ULTRAVIOLET radiation -- Physiological effect; Subject Term: SYNDROMES; Subject Term: ALLERGY; Subject Term: IMMUNOLOGIC diseases; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260999
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hintner, Helmut
AU - Lawley, Thomas J.
T1 - Keratin Intermediate Filaments Bear Antigenic Determinants for Stratum Corneum Antibodies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/05//
VL - 82
IS - 5
M3 - Article
SP - 491
EP - 495
SN - 0022202X
AB - Stratum corneum (SC) antibodies are directed against antigens in the SC of the epidermis and are known to occur in all normal human sera. They have been shown by indirect immunofluorescence to be frequently associated with upper cytoplasmic (U-Cyt) antibodies. We have recently identified keratin intermediate filaments (KIF) as antigens for U-Cyt antibodies. In this study we investigated whether KIF also bear antigenic sites for SC antibodies. Normal human sera that contained SC and/or U-Cyt antibodies by indirect immunofluorescence were studied. Using immunoblot techniques 3 selected sera were shown to bind to high-molecular-weight (HMW) KIF proteins which had been extracted from 2 different epidermal cell preparations, that is, human callus or epidermis from which the SC had been removed by tapestripping. The 3 test sera were absorbed on KIF which had been reconstituted in vitro from urea extracts from both epidermal substrates. As shown by indirect immunofluorescence, the SC and U-Cyt antibodies of all 3 sera were absorbed out with KIF from callus and with KIF from epidermis without SC. Immunoblot experiments, which are more sensitive than indirect immunofluorescence, demonstrated the absorption of anti-KIF protein antibodies of the 3 test sera on callus KIF and 2 of the sera on KIF obtained from epidermis without SC. This was shown by the lack of staining of the respective HMW KIF proteins with the postabsorption sera. With the third serum a marked reduction of antibody binding was found after absorption on KIF from epidermis without SC. These data indicate that KIF bear antigenic sites for SC antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATIN
KW - CYTOPLASMIC filaments
KW - CYTOPLASM
KW - ANTIGENIC determinants
KW - IMMUNOGLOBULINS
KW - EPIDERMIS
N1 - Accession Number: 12261020; Hintner, Helmut 1 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May84, Vol. 82 Issue 5, p491; Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: CYTOPLASM; Subject Term: ANTIGENIC determinants; Subject Term: IMMUNOGLOBULINS; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261020
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Aines, Andrew A.1
T1 - A Visit to the Wasteland of Federal Scientific and Technical Information Policy.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
J1 - Journal of the American Society for Information Science
PY - 1984/05//
Y1 - 1984/05//
VL - 35
IS - 3
CP - 3
M3 - Article
SP - 179
EP - 184
SN - 00028231
AB - Long before the appearance of the Reagan Administration, whose expressed policy was and is the reduction of the Federal Government in all areas save national security, there has been what is almost a precipitous retreat from overall planning and management of Federal scientific and technical information. The exodus got underway during the Nixon Administration in the early 1970s, a few years before the science apparatus was banished from the White House by a president who became disenchanted with scientists, if not science. The problem was that the stiff-necked men of science refused to bow down before the idols of political expediency. [ABSTRACT FROM AUTHOR]
KW - Information policy
KW - Federal regulation
KW - Federal legislation
KW - Communication policy
KW - Economic policy
KW - Scientists
N1 - Accession Number: 16795702; Authors: Aines, Andrew A. 1; Affiliations: 1: Scholar-in-Residence, National Library of Medicine, National Institutes of Health, Bethesda, MD 20209.; Subject: Information policy; Subject: Federal regulation; Subject: Federal legislation; Subject: Communication policy; Subject: Economic policy; Subject: Scientists; Number of Pages: 6p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Wright, David E.
AU - Horuk, Richard
AU - Rodbell, Martin
T1 - Photoaffinity labeling of the glucagon receptor with a new glucagon analog.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/05/15/
VL - 141
IS - 1
M3 - Article
SP - 63
EP - 67
PB - Wiley-Blackwell
SN - 00142956
AB - The preparation, purification and characterization of Nϵ-4-azidophenylamidinoglucagon are described. This photoreactive peptide was found to be 50 % as potent as native glucagon in competing with 125I-labeled glucagon for binding to glucagon receptors on rat liver plasma membranes. Similarly, the analog was 50% as potent as native glucagon in its ability to stimulate adenylate cyclase. The photoreactive glucagon analog was radioiodinated to high specific activity with iodine-125 and was used to label rat liver plasma membrane proteins. Analysis of labeled membrane proteins by sodium dodecyl sulfate/polyacrylamide gel electrophoresis revealed covalent incorporation predominantly into a protein of relative molecular mass, Mr, of 50000-60000. Occasionally a protein of Mr 170000-180000 was also labeled. Irradiation of membranes in the presence of unlabeled glucagon or GTP selectively inhibited the labeling of the 50000-60000-Mr protein(s). As a result of these studies we suggest that the sodium-dodecyl-sulfate-dissociated glucagon receptor is a 50000-60000-Mr protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTOAFFINITY labeling
KW - GLUCAGON
KW - LIVER
KW - CELL membranes
KW - PEPTIDE hormones
KW - MEMBRANE proteins
N1 - Accession Number: 23563525; Wright, David E. 1 Horuk, Richard 1 Rodbell, Martin 1; Affiliation: 1: Laboratory of Cellular and Developmental Biology, National Institute of Arthritis, Diabeles and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.; Source Info: 5/15/84, Vol. 141 Issue 1, p63; Subject Term: PHOTOAFFINITY labeling; Subject Term: GLUCAGON; Subject Term: LIVER; Subject Term: CELL membranes; Subject Term: PEPTIDE hormones; Subject Term: MEMBRANE proteins; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berman, Phyllis W.
AU - Goodman, Vickie
T1 - Age and Sex Differences in Children's Responses to Babies: Effects of Adults' Caretaking Requests and Instructions.
JO - Child Development
JF - Child Development
Y1 - 1984/06//
VL - 55
IS - 3
M3 - Article
SP - 1071
EP - 1077
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 12427540; Berman, Phyllis W. 1 Goodman, Vickie 2; Affiliation: 1: National Institute of Child Health and Human Development. 2: Florida State University.; Source Info: Jun1984, Vol. 55 Issue 3, p1071; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1467-8624.ep12427540
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaushal, Nuzhat A.
AU - Hussain, Rabia
AU - Ottesen, E. A.
T1 - Excretory-secretory and somatic antigens in the diagnosis of human filariasis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/06//
VL - 56
IS - 3
M3 - Article
SP - 567
EP - 576
PB - Wiley-Blackwell
SN - 00099104
AB - In order to compare the immunodiognostic value of excretory-secretory (E-S) antigens derived from adult Brugia malayi worms with somatic antigens derived from adults, microfilariae (MO and infective larvae (L3) of these parasites, well defined serum pools from patients with filarial (brugia. bancrofti,, Ioa and perstans) and non-filarial (ascaris. stronglyoides, toxocara. echinococcus, cysticercus and schistosoma) helminth infections were tested against antigens derived from these different life cycle stages of B. malayi in a Staphylococcus aureus radioimmunoprecipitation assay (5. aureus RIA). The adult brugia antigens proved significantly more discriminatory than those of the other parasite stages, with the homologous brugia serum pool also showing greater reactivity to adult than to L3 and Mf antigens. Similar results were obtained when individual sera from patients (rather than serum pools) were tested in the same assay. The most surprising finding was the minimal reactivity seen between the adult filarial antigens and the non-filarial serum pools despite the presence in these pools of strong antibody reactivity with their homologous antigens. The reasons underlying the unexpected specificity of this S, aureus RIA for discriminating among sera from filarial and non-filarial infections were analysed qualitatively by immunoprecipitation techniques. It was found that use of the chloramine- T method for radioiodination resulted in preferential labelling of the low molecular weight (mol. wt) proteins (10-70.000 daltons) in the B. malayi adult somatic antigen and that these antigens were bound primarily by the filarial and not the non-filarial serum pools. These findings suggest that lower mol. wt helminth antigens may show greater species specificity than those with higher mol. wt, and those with higher mol. wt. greater cross-reactivity. If substantiated by further analysis, such results would have important implications for the subsequent isolation of diagnostically important filarial parasite antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXCRETION
KW - FILARIASIS
KW - DIAGNOSIS
KW - SOMATIC hybrids
KW - ECHINOCOCCUS
KW - STAPHYLOCOCCUS aureus
KW - E-S antigen
KW - filariasis
KW - human
KW - immunodiagnosis
N1 - Accession Number: 16247536; Kaushal, Nuzhat A. 1 Hussain, Rabia 1 Ottesen, E. A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jun1984, Vol. 56 Issue 3, p567; Subject Term: EXCRETION; Subject Term: FILARIASIS; Subject Term: DIAGNOSIS; Subject Term: SOMATIC hybrids; Subject Term: ECHINOCOCCUS; Subject Term: STAPHYLOCOCCUS aureus; Author-Supplied Keyword: E-S antigen; Author-Supplied Keyword: filariasis; Author-Supplied Keyword: human; Author-Supplied Keyword: immunodiagnosis; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coomes, Marguerite Wilton
AU - Sparks, Rebecca W.
AU - Fouts, James R.
T1 - Oxidation of 7-Ethoxycoumarin and Conjugation of Umbelliferone by Intact, Viable Epidermal Cells from the Hairless Mouse.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/06//
VL - 82
IS - 6
M3 - Article
SP - 598
EP - 601
SN - 0022202X
AB - Intact, viable (>80%) epidermal cells were isolated from the hairless mouse. These cells metabolized 7-ethoxycoumarin (7-EC) to umbelliferone (UMB) (3 pmol/min/106 cells) and UMB to the sulfate and glucuronide conjugates (1 pmol/min/106 cells). The rate of oxidation in intact cells compared well with that in disrupted cells with added NADPH, but conjugation proceeded more rapidly in disrupted cells with added cofactors, due to a combination of "activation" of the UDP-glucuronosyltransferase, and to a limitation of activity by the concentration of UDP-glucuronic acid in the intact cells. Pretreatment of the animals with 5,6-benzoflavone resulted in a 5-fold increase in the rate of oxidation, and a 2-fold increase in both the rate of conjugation and the intracellular concentration of UDP-glucuronic acid. UDP-glucuronic acid concentration in isolated cells increased during incubation with glucose, and was regenerated to a steady-state concentration on incubation of cells with UMB. Pretreatment of animals with 5,6-benzoflavone decreased the percentage of metabolite conjugated (from 30% to 15%), whereas adding an inhibitor of oxidation, ellipticine, to cells isolated from pretreated animals, increased the percentage of metabolite conjugated (from 15% to 40%). Sulfation of UMB was almost undetectable, except at very low concentrations (<10 nm) of substrate. Thus, glucuronidation of UMB in epidermal cells may be limited by UDP-glucuronic acid availability; sulfation in the epidermis may contribute little to the conjugation of UMB; and >70% of the products of 7-EC oxidation in the skin may remain unconjugated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - EPIDERMIS
KW - MICE as laboratory animals
KW - GLUCOSE
KW - OXIDATION
KW - EPITHELIUM
KW - CHEMICAL inhibitors
KW - SKIN
N1 - Accession Number: 12261390; Coomes, Marguerite Wilton 1 Sparks, Rebecca W. 1 Fouts, James R. 1; Affiliation: 1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, U.S.A.; Source Info: Jun84, Vol. 82 Issue 6, p598; Subject Term: CELLS; Subject Term: EPIDERMIS; Subject Term: MICE as laboratory animals; Subject Term: GLUCOSE; Subject Term: OXIDATION; Subject Term: EPITHELIUM; Subject Term: CHEMICAL inhibitors; Subject Term: SKIN; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261390
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12261390&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DiGiovanna, John J.
AU - Gross, Earl G.
AU - McClean, Sharon W.
AU - Ruddel, Mark E.
AU - Gantt, Gail
AU - Peck, Gary L.
T1 - Etretinate: Effect of Milk Intake on Absorption.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/06//
VL - 82
IS - 6
M3 - Article
SP - 636
EP - 640
SN - 0022202X
AB - Since etretinate, an aromatic retinoid useful in the treatment of psoriasis and other skin disorders is lipid-soluble, it may be poorly absorbed in the absence of a fat load. We therefore studied serum concentrations of etretinate and its major metabolite (Ro 10-1670) after the controlled administration of etretinate. After an overnight fast, 6 Darier's disease and 4 psoriatic patients received a 1 mg/kg morning dose of etretinate with water or 1 pint of whole milk (fat load). There was a 260% increase (p < 0.0005) in the mean of each patient's increase in the baseline-corrected peak serum concentration of etretinate after administration with milk (115 ± 15 μg/dl) compared to after administration with water (32 ± 4 μg/dl). Over a 24-h period there was an overall 296 ± 26% (p < 0.0005) increase in serum etretinate after administration with milk compared to water in 5 patients with Darier's disease. In contrast to the serum etretinate, there was a 17% mean decrease (p < 0.025) in the corrected peak serum concentration of Ro 10-1670 in all 10 patients after administration of etretinate with milk compared to water. The net result of these alterations is that the mean corrected serum concentration of etretinate is higher than Ro 10-1670 at all time points measured after milk administration. In contrast, after administration of etretinate with water the major retinoid in the serum is Ro 10-1670. Establishing the clinical significance of these alterations may require controlled clinical trials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETRETINATE
KW - RETINOIDS
KW - PSORIASIS
KW - SKIN diseases
KW - SERUM
KW - KERATOSIS follicularis
KW - PATIENTS
KW - CLINICAL trials
N1 - Accession Number: 12261476; DiGiovanna, John J. 1 Gross, Earl G. 1 McClean, Sharon W. 2 Ruddel, Mark E. 2 Gantt, Gail 1 Peck, Gary L. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Clinical Chemistry, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun84, Vol. 82 Issue 6, p636; Subject Term: ETRETINATE; Subject Term: RETINOIDS; Subject Term: PSORIASIS; Subject Term: SKIN diseases; Subject Term: SERUM; Subject Term: KERATOSIS follicularis; Subject Term: PATIENTS; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261476
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12261476&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emilson, C. G.
AU - Nilsson, B.
AU - Bowen, W. H.
T1 - Carbohydrate composition of dental plaque from primates with irradiation caries.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1984/06//
VL - 13
IS - 3
M3 - Article
SP - 213
EP - 220
SN - 03009777
AB - Carbohydrate analyses were performed on dental plaque collected from the teeth of irradiated monkeys, non-irradiated monkeys and a group of Streptociccus mutans free animals, all of which were fed the same standard cariogenic diet. Glucose was the predominant sugar constituent in plaque and was detected in highest concentration in the irradiated animals. Small amounts of pentoses and other hexoses were also present. Plaque from irradiated animals contained, by comparison with the other groups, higher levels of Strep mutans and lower levels of Streptococcus sanguis and Actinomyees. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBOHYDRATES
KW - DENTAL plaque
KW - GLUCOSE
KW - DIET
KW - PENTOSES
KW - MONKEYS
N1 - Accession Number: 11504347; Emilson, C. G. 1 Nilsson, B. 2 Bowen, W. H. 1; Affiliation: 1: National Caries Program, National Institute of Dental Research, Bethesda, Maryland, U.S.A. 2: National Cancer Institute, National Institute s of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun84, Vol. 13 Issue 3, p213; Subject Term: CARBOHYDRATES; Subject Term: DENTAL plaque; Subject Term: GLUCOSE; Subject Term: DIET; Subject Term: PENTOSES; Subject Term: MONKEYS; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1600-0714.ep11504347
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campbell, Arthur A.
T1 - Determinants of Fertility in Developing Countries.
JO - Population & Development Review
JF - Population & Development Review
Y1 - 1984/06//
VL - 10
IS - 2
M3 - Book Review
SP - 371
EP - 373
SN - 00987921
AB - Reviews the book "Determinants of Fertility in Developing Countries," edited by Rodolfo A. Bulatao and Ronald D. Lee.
KW - FERTILITY
KW - NONFICTION
KW - BULATAO, Rodolfo A.
KW - LEE, Ronald D.
KW - DETERMINANTS of Fertility in Developing Countries (Book)
N1 - Accession Number: 16667334; Campbell, Arthur A. 1; Affiliations: 1: Center for Population Research National Institute of Child Health and Human Development National Institutes of Health; Issue Info: Jun1984, Vol. 10 Issue 2, p371; Subject Term: FERTILITY; Subject Term: NONFICTION; Reviews & Products: DETERMINANTS of Fertility in Developing Countries (Book); People: BULATAO, Rodolfo A.; People: LEE, Ronald D.; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Ayala, F.
AU - Balato, N.
AU - Cefarano, S.
AU - Castellot, G.
T1 - Immunochemical characterization of the abnormal paraprotein in a case of scleromyxoedema.
JO - Clinical & Experimental Dermatology
JF - Clinical & Experimental Dermatology
Y1 - 1984/07//
VL - 9
IS - 4
M3 - Article
SP - 351
EP - 357
SN - 03076938
AB - The monoclonal paraprotein from the serum of a patient with scleromyxoedema was characterized as IgG-λ class. No abnormalities involving antigenic properties of the Fab, Fc, and Fd portions of the molecule were observed. In order to examine the paraprotein thoroughly, IgG was isolated from the serum by a standard procedure that unexpectedly induced an inexplicable cleavage of the molecule and evidenced an unusual hidden Fc deficiency of monoclonal protein. The hypothesis about significant structural abnormalities of this seleromyxoedema paraprotein was supported by its sedimentation coefficient (S[SUB20,w] = 6.41) and molecular weight (104,000 daltons). [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARAPROTEINEMIA
KW - BLOOD protein disorders
KW - MOLECULES
KW - IMMUNOGLOBULIN G
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
N1 - Accession Number: 11678174; Ayala, F. 1; Balato, N. 1; Cefarano, S. 2; Castellot, G. 2; Source Information: Jul84, Vol. 9 Issue 4, p351; Subject: PARAPROTEINEMIA; Subject: BLOOD protein disorders; Subject: MOLECULES; Subject: IMMUNOGLOBULIN G; Subject: MONOCLONAL antibodies; Subject: IMMUNOGLOBULINS; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1365-2230.ep11678174
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=11678174&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Gerrard, Theresa L.
AU - Jurgensen, Cynthia H.
AU - Fauci, A. S.
T1 - Modulation of human B cell responses by a monoclonal antibody to an activation antigen 4F2.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/07//
VL - 57
IS - 1
M3 - Article
SP - 155
EP - 162
PB - Wiley-Blackwell
SN - 00099104
AB - Antigen specific human antibody responses can be modulated in vitro by the addition of 4F2 antibody, a monoclonal antibody (MoAb) which recognizes an antigen on activated T cells and B ceils. Specific antibody responses induced with the antigen are suppressed by the addition of 4F2. However, specific antibody responses induced with the polyclonal activator, pokeweed mitogen (PWM), are significantly enhanced by the addition or 4F2. Proliferative responses to both antigen and PWM are suppressed by the addition of 4F2. The enhancement of PWM stimulated responses by 4F2 is mediated by T cells. However, in the absence of T cells. 4F2 can directly inhibit antigen specific B cells. Polyclonal Ig production stimulated by PWM was also enhanced by 4F2. Thus, the immunomodulating effects of the 4F2 MoAb are the result of a balance of enhancement and suppression mediated at the T cell and the B cell level, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - T cells
KW - B cells
KW - LYMPHOCYTES
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - 4F2
KW - activation antigcn
KW - B cell responses
KW - monoclonal antibodies
N1 - Accession Number: 17561826; Gerrard, Theresa L. 1 Jurgensen, Cynthia H. 1 Fauci, A. S. 1; Affiliation: 1: Laboratory of immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jul1984, Vol. 57 Issue 1, p155; Subject Term: MONOCLONAL antibodies; Subject Term: T cells; Subject Term: B cells; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Author-Supplied Keyword: 4F2; Author-Supplied Keyword: activation antigcn; Author-Supplied Keyword: B cell responses; Author-Supplied Keyword: monoclonal antibodies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fine, Jo-David
AU - Smith, Lynne T.
AU - Holbrook, Karen A.
AU - Katz, Stephen I.
T1 - The Appearance of Four Basement Membrane Zone Antigens in Developing Human Fetal Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/07//
VL - 83
IS - 1
M3 - Article
SP - 66
EP - 69
SN - 0022202X
AB - In order to study the ontogeny of various structural and antigenic components of the basement membrane zone of human skin, we have examined skin specimens from 20 aborted fetuses ranging in gestational ages from 6 to 25 weeks, utilizing light microscopy, transmission electron microscopy, and indirect immunofluorescence with antibodies to bullous pemphigoid antigen, laminin, type IV collagen, and to the antigen defined by KF-1 monoclonal antibody. Both laminin and type IV collagen were detectable as early as 6 weeks of gestational age. In contrast, bullous pemphigoid antigen and the antigen defined by KF- 1 antibody were not detectable before 10 weeks and 16 weeks, respectively. The appearance of bullous pemphigoid antigen correlated with stratification of the epidermis and the formation of hemidesmosomes and anchoring fibrils at the basement membrane zone. KF- 1 antigen is first expressed when the epidermis is further stratified, hemidesmosomes and anchoring fibrils are present in greater numbers and with increased frequency at the dermal-epidermal junction, and hair follicles have begun to bud downward from the basal layer of the epidermis. Our findings suggest an orderly sequence to the appearance of these basement membrane zone components within human skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONTOGENY
KW - EMBRYOLOGY
KW - ANTIGENS
KW - IMMUNITY
KW - GESTATIONAL age
KW - ELECTRON microscopy
N1 - Accession Number: 12261707; Fine, Jo-David 1 Smith, Lynne T. 2,3 Holbrook, Karen A. 2,3 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2: Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington, U.S.A. 3: Department of Medicine (Dermatology), University of Washington School of Medicine, Seattle, Washington, U.S.A.; Source Info: Jul84, Vol. 83 Issue 1, p66; Subject Term: ONTOGENY; Subject Term: EMBRYOLOGY; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Subject Term: GESTATIONAL age; Subject Term: ELECTRON microscopy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261707
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12261707&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breathnach, Stephen M.
AU - Katz, Stephen I.
T1 - Thy-1+ Dendritic Cells in Murine Epidermis Are Bone Marrow-Derived.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/07//
VL - 83
IS - 1
M3 - Article
SP - 74
EP - 77
SN - 0022202X
AB - Thy-1+ Ly-5+ dendritic cells have recently been described as a resident cell population in murine epidermis, but their ontogeny and function are unknown. We therefore investigated the origin and turnover of epidermal Thy- 1+ cells utilizing chimeric mice. Lethally x- irradiated AKR/J (Thy-1.1+) and AKR/Cum (Thy-1.2+ mice were reconstituted with allogeneic bone marrow cells with or without thymocytes from congenic AKR/ Cum or AKR/J mice, respectively. The density of residual indigenous Thy-1.1+ cells in AKR/J chimeras and Thy-1.2+ cells in AKR/Cum chimeras was substantially reduced following x-irradiation, as determined by immunofluorescence staining of epidermal sheets. Epidermal repopulation by allogeneic Thy-1+ dendritic epidermal cells was first observed at 5 weeks in AKR/J chimeras and at 7 weeks in AKR/Cum chimeras and progressed slowly. Repopulation was not enhanced by increasing the number of allogeneic bone marrow cells injected from 2 × 107 to 108 cells or by the addition of 8 x 107 allogeneic thymocytes to the donor inoculate. Epidermal repopulation by allogeneic Thy-1.2+ cells was not seen in AKR/J mice reconstituted with syngeneic bone marrow cells and allogeneic Thy-1.2+ AKR/Cum thymocytes. Taken together, these results indicate that Thy-1+ dendritic epidermal cells are derived from the bone marrow and suggest that they are not related to conventional peripheral T-lymphocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENDRITIC cells
KW - EPIDERMIS
KW - ONTOGENY
KW - BONE marrow
KW - IMMUNE system
KW - IRRADIATION
N1 - Accession Number: 12261808; Breathnach, Stephen M. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84, Vol. 83 Issue 1, p74; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS; Subject Term: ONTOGENY; Subject Term: BONE marrow; Subject Term: IMMUNE system; Subject Term: IRRADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12261808
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12261808&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY -
AU - Bernstein, Lionel M.1
AU - Williamson, Robert E.1
T1 - Testing of a Natural Language Retrieval System for a Full Text Knowledge Base.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
J1 - Journal of the American Society for Information Science
PY - 1984/07//
Y1 - 1984/07//
VL - 35
IS - 4
CP - 4
M3 - Article
SP - 235
EP - 247
SN - 00028231
AB - "A Navigator of Natural Language Organized Data" (ANNOD) is a retrieval system which combines use of probabilistic, linguistic, and empirical means to rank individual paragraphs of full text for their similarity to natural language queries proposed by users. ANNOD includes common word deletion, word root isolation, query expansion by a thesaurus, and application of a complex empirical matching (ranking) algorithm. The Hepatitis Knowledge Base, the text of a prototype information system, was the file used for testing ANNOD. Responses to a series of users' unrestricted natural language queries were evaluated by three testers. Information needed to answer 85 to 95% of the queries was located and displayed in the first few selected paragraphs. It was successful in locating information in both the classified (listed in Table of Contents) and unclassified portions of text. Development of this retrieval system resulted from the complementarity of and interaction between computer science and medical domain expert knowledge. Extension of these techniques to larger knowledge bases is needed to clarify their proper role. [ABSTRACT FROM AUTHOR]
KW - Natural language processing (Computer science)
KW - Text files
KW - Algorithms
KW - Information storage & retrieval systems
KW - Expansion (Business)
KW - Technology
N1 - Accession Number: 16801368; Authors: Bernstein, Lionel M. 1; Williamson, Robert E. 1; Affiliations: 1: Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, MD 20209; Subject: Natural language processing (Computer science); Subject: Text files; Subject: Algorithms; Subject: Information storage & retrieval systems; Subject: Expansion (Business); Subject: Technology; Number of Pages: 13p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Nakabayashi, Yasuharu
AU - Dvoretzky, Israel
AU - Chattopadhyay, Sisir K.
AU - Lowy, Douglas R.
T1 - In Vitro Transformation by Bovine Papillomavirus.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/07/15/Jul84 Supplement
VL - 83
M3 - Article
SP - 12s
EP - 17s
SN - 0022202X
AB - We have studied tumorigenic transformation of mouse tissue culture cells by bovine papillomavirus (BPV) as a model of papillomavirus-induced cell proliferation. When BPV or its 7.9-kb full-length viral DNA genome induces focal transformation of mouse calls, the viral DNA is maintained in the transformed cells as multiple extrachromosomal copies. The transforming capacity was initially localized to a 69% subgenomic fragment of the viral DNA genome. We have further characterized the BPV DNA sequences that can encode the transforming function by generating and analyzing the transforming activity of a series of BPV DNA deletion mutants. The results indicated that two discontinuous segments of the viral DNA are required for transformation. One segment, near the 5' end of the 69% transforming fragment, probably represents a control element of the viral DNA. The second segment, which lies within the 3' end of the 69% fragment, encodes transforming sequences of the viral DNA. A retroviral control element (the long terminal repeat DNA of Harvey murine sarcoma virus) will activate the 2.3-kb segment at the 3' end of the 69% fragment to transform the mouse cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAPILLOMAVIRUSES
KW - ONCOGENIC viruses
KW - CELL proliferation
KW - GENOMES
KW - NUCLEOTIDE sequence
KW - DNA
N1 - Accession Number: 12281119; Nakabayashi, Yasuharu 1 Dvoretzky, Israel 1 Chattopadhyay, Sisir K. 1 Lowy, Douglas R. 1; Affiliation: 1: Dermatology Brunch and Laboratory of Cellular Oncology, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p12s; Subject Term: PAPILLOMAVIRUSES; Subject Term: ONCOGENIC viruses; Subject Term: CELL proliferation; Subject Term: GENOMES; Subject Term: NUCLEOTIDE sequence; Subject Term: DNA; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12281119
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12281119&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Franchini, G.
AU - Wong-Staal, F.
AU - Gallo, R. C.
T1 - Molecular Studies of Human T-Cell Leukemia Virus and Adult T-Cell Leukemia.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/07/15/Jul84 Supplement
VL - 83
M3 - Article
SP - 63s
EP - 66s
SN - 0022202X
AB - We describe previously published work as well as new data on the molecular biology of human T-cell leukemia virus (HTLV) and its associated disease, adult T-cell leukemia-lymphoma (ATLL). This specific kind of disease is endemic to certain areas of Japan and the Caribbean, and several isolated cases have been described also in the United States, Israel, South America, and Africa. The disease is probably also endemic to Africa and South America, but sufficient studies of these areas have not been performed. We have molecularly cloned the HTLV genome and used the viral DNA as a probe in a large molecular study of the DNAs of human hematopoietic malignancies. The results showed that HTLV sequences could be detected in the fresh leukemic cells of all cases of ATLL tested. The neoplastic cells are of clonal origin and contain one or few copies of integrated HTLV. Detailed comparative analyses by restriction enzyme mapping of the proviral DNA in U.S., Japanese, Caribbean, and Israeli cases revealed that the viruses are almost indistinguishable. The DNA from neoplastic cells of other cases of hematopoietic neoplasias analyzed were negative for HTLV sequences with the exception of two. DNA from cells of a patient (MO) with a T-cell variant of hairy cell leukemia did contain a provirus only distantly related to HTLV (less than 10% of DNA sequence homology). The virus isolated from the MO cells has been designated HTLV-II. The second case was a patient with chronic myeloid leukemia whose cells contained exogenous DNA sequences distantly related to HTLV. Different fragments of the clones HTLV genome have been used to hybridize to DNA from uninfected normal tissues of several vertebrate species, including humans, in a search for cell-derived sequences related to the HTLV genome. No homologous sequences were found except sequences distantly related to the pol and env genes, indicating that HTLV does not carry a cellularly derived one gene. Surprisingly, however, infection of normal human fresh T cells by HTLV transforms them into cells with permanent growth and with several other properties similar to neoplastic T cells. We have also studied the expression of viral and cellular genes in fresh and cultured neoplastic cells from patients with ATLL. Several species of viral mRNAs are always detected in the cultured neoplastic cells, whereas in some fresh samples expression of normal mRNA was not detected. The lack of viral mRNA in some of the fresh sample suggested that the neoplastic transformation could be maintained without the expression of viral genes. Because T cells of patients with ATLL as well as cells transformed in vitro by HTLV do have a decreased or no requirement for T-cell growth factor (TCGF; IL-2) for growth in vitro and exhibit a high number of TCGF cell surface receptors, we hypothesized that HTLV infection may involve the transcriptional activation of the TCGF gene concomitant with TCGF-induced persistent cell proliferation. However, only low-level expression of the TCGF gene was found in 2 or 5 cell lines and in none of the two fresh samples. Thus autostimulation by TCGF of one cell interacting with its own receptor cannot be the mechanism for initiation or maintenance of the abnormal growth induced by HTLV. We also analyzed the RNAs of the HTLV-infected cells for the expression of various one genes. None of the one genes tested seemed to be transcriptionally activated int eh fresh leukemic cells, with the exception of the sis gene, which is expressed at high level in two neoplastic cell lines (HUT 102 and MO) infected with HTLV-I and HTLV-II, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HTLV (Viruses)
KW - MOLECULAR biology
KW - GENOMES
KW - DNA viruses
KW - LEUKEMIC reticuloendotheliosis
KW - ADULT T-cell leukemia
N1 - Accession Number: 12281191; Franchini, G. 1 Wong-Staal, F. 1 Gallo, R. C. 1; Affiliation: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p63s; Subject Term: HTLV (Viruses); Subject Term: MOLECULAR biology; Subject Term: GENOMES; Subject Term: DNA viruses; Subject Term: LEUKEMIC reticuloendotheliosis; Subject Term: ADULT T-cell leukemia; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12281191
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Herberman, Ronald B.
T1 - Possible Role of Natural Killer Cells and Other Effector Cells in Immune Surveillance Against Cancer.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/07/15/Jul84 Supplement
VL - 83
M3 - Article
SP - 137s
EP - 140s
SN - 0022202X
AB - The concept of immune surveillance against cancer was initially formulated with thymus-dependent immunity as a central and requisite effector mechanism. However, a substantial amount of evidence has accumulated to indicate that T cell-mediated immunity is mainly important for protection against tumors induced by oncogenic viruses and not for many other types of spontaneous or chemical carcinogen-induced tumors. It now appears likely that various components of the natural immune system also play major roles in immune surveillance. These include natural killer (NK) cells and macrophages. The existing evidence for the roles of these effector cells is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - CANCER
KW - THYMUS
KW - T cells
KW - IMMUNITY
KW - TUMORS
KW - ONCOGENIC viruses
KW - MACROPHAGES
N1 - Accession Number: 12282012; Herberman, Ronald B. 1; Affiliation: 1: Biological Therapeutics Branch, National Cancer Institute, Frederick, Maryland, U.S.A.; Source Info: Jul84 Supplement, Vol. 83, p137s; Subject Term: KILLER cells; Subject Term: CANCER; Subject Term: THYMUS; Subject Term: T cells; Subject Term: IMMUNITY; Subject Term: TUMORS; Subject Term: ONCOGENIC viruses; Subject Term: MACROPHAGES; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12282012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Westerhoff, Hans V.
AU - Yi-Der Chen
T1 - How do enzyme activities control metabolite concentrations?
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/07/16/
VL - 142
IS - 2
M3 - Article
SP - 425
EP - 430
PB - Wiley-Blackwell
SN - 00142956
AB - A simple theorem is derived relating the extent to which enzymes in a metabolic pathway control the steady-state concentration of metabolites to the kinetic properties of those enzymes. The theorem gives insight into the mechanism by which the concentration of a second messenger is controlled by the enzymes that form and degrade it, and provides an alternative to the ‘cross-over theorem’. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYMES
KW - PROTEINS
KW - METABOLITES
KW - BIOMOLECULES
KW - METABOLISM
KW - ENZYMOLOGY
KW - BIOCHEMISTRY
N1 - Accession Number: 13852518; Westerhoff, Hans V. 1 Yi-Der Chen 1; Affiliation: 1: Laboratory of Biochemistry, B. C. P. Jansen Instituut, University of Amsterdam; and Laboratory of Molecular Biology, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; Source Info: 7/16/84, Vol. 142 Issue 2, p425; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: METABOLITES; Subject Term: BIOMOLECULES; Subject Term: METABOLISM; Subject Term: ENZYMOLOGY; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hanson, R. G.
AU - Hoofnagle, J. H.
AU - Minuk, G. Y.
AU - Purcell, R. H.
AU - Gerin, J. L.
T1 - Cell-mediated immunity to hepatitis B surface antigen in man.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/08//
VL - 57
IS - 2
M3 - Article
SP - 257
EP - 264
PB - Wiley-Blackwell
SN - 00099104
AB - An aqueous preparation of hepatitis B virus (HBV) vaccine was used as an intradermal skin lest antigen to assess delayed hypersensitivity to hepatitis B surface antigen (HBsAg). Thirty-five persons were tested including 10 individuals seronegative for all HBV markers. 10 positive for HBsAg (chronic carriers) and 15 positive for antibody to HBsAg (anti-HBs), five of whom had received the HBV vaccine. Ali patients were also studied for lymphocyte blastogenic responses to phytohaemagglutinin, concanavalin A, pokeweed mitogen and purified HBsAg. Only one individual had a positive delayed skin test reaction to HBsAg. This person had received the HBV vaccine and had high titres of anti-HBs in serum. However, neither this individual nor any other subject exhibited a positive lymphocyte blastogenic response to HBsAg in vitro. Thus, delayed hypersensitivity skin test reactivity to HBsAg was not detected after natural infection with HBV and was rarely present in hyperimmunized individuals. In vitro assays of immune responsiveness failed to demonstrate cellular immunity to HBsAg even in hyperimmunized persons. These studies provide no evidence that cell-mediated immunity to HBsAg plays a role in the immunopathogenesis of acute or chronic type B hepatitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B
KW - IMMUNITY
KW - VACCINES
KW - ANTI-idiotypic vaccines
KW - IMMUNOGLOBULINS
KW - LIVER diseases
KW - hepatitis B surface antigen chronic hepatitis hepatitis B virus vaccine delayed hypersensitivity
N1 - Accession Number: 15939834; Hanson, R. G. 1 Hoofnagle, J. H. 1 Minuk, G. Y. 1 Purcell, R. H. 2 Gerin, J. L. 1; Affiliation: 1: Liver Diseases Section, Digestive Diseases Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases. 2: Hepatitis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda and Molecular Virology and Immunology Division, Georgetown University, Rockville, Maryland, USA.; Source Info: Aug1984, Vol. 57 Issue 2, p257; Subject Term: HEPATITIS B; Subject Term: IMMUNITY; Subject Term: VACCINES; Subject Term: ANTI-idiotypic vaccines; Subject Term: IMMUNOGLOBULINS; Subject Term: LIVER diseases; Author-Supplied Keyword: hepatitis B surface antigen chronic hepatitis hepatitis B virus vaccine delayed hypersensitivity; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Curtis, J. L.
AU - Nordin, A. A.
T1 - Primary in vitro plaque-forming cell response to DAGG-Ficoll: LPS-induced enhancement mediated by interleukin-1.
JO - Immunology
JF - Immunology
Y1 - 1984/08//
VL - 52
IS - 4
M3 - Article
SP - 711
EP - 719
PB - Wiley-Blackwell
SN - 00192805
AB - The specific primary in vitro plaque-forming cell (PFC) response of C57B1/6 nu/nu spleen cells to the Type 2 T-independent (TI-2) antigen DAGG-Ficoll was analysed in the absence of T cell help in a serum-free medium. Lipopolysaccharide (LPS) enhancement of the antigen-specific response was shown to be mediated by soluble factors contained in the supernatants of LPS-induced bone marrow-derived macrophages. The activity of these supernatants was not associated with residual LPS, since the antigenspecific response of B cells from mice genetically deficient in LPS receptors was equally well enhanced. The activity of these supernatants was associated with interleukin-1 (IL-1) and partially purified IL-1 prepared from P388D1 cells also enhanced the primary in vitro response to DAGG-Ficoll. Limiting dilution analysis experiments showed that only in the presence of exogenously added IL-1 could a single cell type, presumably the B cells, be shown to be limiting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - INTERLEUKIN-1
KW - ENDOTOXINS
KW - MACROPHAGES
KW - B cells
KW - ANTIGENS
N1 - Accession Number: 13947805; Curtis, J. L. 1 Nordin, A. A. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center National Institute on Aging, National Institutes of Health, PHS, U. S. Department of Health and Human Services, Bethesda and Baltimore City Hospitals, Baltimore, Maryland, U.S.A.; Source Info: Aug84, Vol. 52 Issue 4, p711; Subject Term: T cells; Subject Term: INTERLEUKIN-1; Subject Term: ENDOTOXINS; Subject Term: MACROPHAGES; Subject Term: B cells; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Costa, Jr., Paul T.
AU - McCrae, Robert R.
AU - Holland, JohnL.
T1 - Personality and Vocational Interests in an Adult Sample.
JO - Journal of Applied Psychology
JF - Journal of Applied Psychology
Y1 - 1984/08//
VL - 69
IS - 3
M3 - Article
SP - 390
EP - 400
SN - 00219010
AB - This article examines the relations between Holland's vocational typology and the Neuroticism-Extraversion-Openness (NEO) model of personality in a sample of men (N = 217) and women (N = 144) aged 21 to 89. Young and old adult groups were similar to college students in most vocational interests, and the same pattern of sex differences was found. Correlations between Self-Directed Search (SDS) scales and NEO scores showed strong associations of Investigative and Artistic interests with Openness to Experience, and of Social and Enterprising interests with Extraversion. Individuals interested primarily in Conventional occupations tended to be closed to experience. These associations were generally confirmed when spouse ratings were used as a non-self-report measure of personality traits in a subset of the subjects. The NEO complements the Holland typology, primarily in providing measures of Neuroticism. Research on the possible utility of supplementing vocational interest data with personality measures is suggested, and some implications for vocational counseling among older adults are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERSONALITY & occupation
KW - VOCATIONAL interests
KW - OCCUPATIONS
KW - VOCATIONAL guidance
KW - PERSONALITY
KW - PSYCHOLOGY
KW - EDUCATION, TRAINING, AND CAREER DEVELOPMENT
N1 - Accession Number: 6239338; Costa, Jr., Paul T. 1; McCrae, Robert R. 1; Holland, JohnL. 2; Affiliations: 1: Gerontology Research Center, National Institute on Aging, National Institutes of Health.; 2: Johns Hopkins University.; Issue Info: Aug84, Vol. 69 Issue 3, p390; Thesaurus Term: PERSONALITY & occupation; Thesaurus Term: VOCATIONAL interests; Thesaurus Term: OCCUPATIONS; Thesaurus Term: VOCATIONAL guidance; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGY; Author-Supplied Keyword: EDUCATION, TRAINING, AND CAREER DEVELOPMENT; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 11p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Schoenberg, Ronald
AU - Richtand, Carol
T1 - Application of the EM Method.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1984/08//
VL - 13
IS - 1
M3 - Article
SP - 127
SN - 00491241
AB - The article studies the application of the estimation-maximization (EM) algorithm to provide maximum likelihood of the parameters of multiple indicator/factor analysis models. Current methods for the maximum likelihood estimation of multiple indicator measurement models and factor analysis models are quite complicated given that they involve the calculation of first-and second-order partial derivatives of the maximum likelihood function as well as a very sophisticated iterative method. It is computationally simpler than the currently used methods-first- and second-order partial derivatives are not calculated, nor is the calculation of the function itself necessary-and computer programs that implement the EM method require considerably less storage, far fewer instructions, and less precision than the usual methods. The computational burden is so reduced that microcomputers may be programmed to estimate measurement models that at one time taxed the resources of the CDC 6400. If the final maximum likelihood estimates of the parameters were used in the computation of the values of the latent variables, then the estimates of the latent variables would be regression method factor scores.
KW - ALGORITHMS
KW - ESTIMATION theory
KW - VARIABLES (Mathematics)
KW - LATENT structure analysis
KW - CORRELATION (Statistics)
KW - FACTOR analysis
KW - PATH analysis (Statistics)
N1 - Accession Number: 5819142; Schoenberg, Ronald 1; Richtand, Carol 2; Source Information: Aug84, Vol. 13 Issue 1, p127; Subject: ALGORITHMS; Subject: ESTIMATION theory; Subject: VARIABLES (Mathematics); Subject: LATENT structure analysis; Subject: CORRELATION (Statistics); Subject: FACTOR analysis; Subject: PATH analysis (Statistics); Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2006-06415-036
AN - 2006-06415-036
AU - Hadley, Suzanne W.
T1 - Major and Not so Major Therapies.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1984/08//
VL - 29
IS - 8
SP - 662
EP - 663
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06415-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychotherapeutic Techniques; Psychotherapy. Minor Descriptor: Therapeutic Processes. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Hariman, Jusuf (Ed). The Therapeutic Efficacy of the Major Psychotherapeutic Techniques=Springfield, IL: Charles C. Thomas, 1983. 368 pp. $33.50; 1983. Page Count: 2. Issue Publication Date: Aug, 1984.
AB - Reviews the book, The Therapeutic Efficacy of the Major Psychotherapeutic Techniques by Jusuf Hariman (Ed.) (1983). The overall value of an edited volume depends in large part on the composition of the collected articles or chapters. This volume is a disappointment. Two limitations are particularly evident. First, although the implicit claims for the volume are noteworthy, the scope of the collection is limited and subject to serious question. The second major limitation is the volume's failure to achieve its stated purposes. This volume is perhaps best seen as a catalogue of widely varying, frequently esoteric approaches to psychotherapy. It reveals the extraordinary range of treatment techniques, it reveals the extraordinary range of problems and deficiencies at which these techniques are directed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - therapeutic efficacy
KW - psychotherapeutic techniques
KW - psychotherapy
KW - 1984
KW - Psychotherapeutic Techniques
KW - Psychotherapy
KW - Therapeutic Processes
KW - 1984
U2 - Hariman, Jusuf (Ed). (1983); The Therapeutic Efficacy of the Major Psychotherapeutic Techniques; Springfield, IL: Charles C. Thomas, 1983. 368 pp. $33.50
DO - 10.1037/023123
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Pearl, David
T1 - Violence and Aggression.
JO - Society
JF - Society
Y1 - 1984/09//Sep/Oct84
VL - 21
IS - 6
M3 - Article
SP - 17
EP - 22
SN - 01472011
AB - This article discusses studies on the issue of violence on television in the U.S. The first congressional hearing on television programming took place in 1952 in the U.S. to investigate if television entertainment was excessively violent and sexually provocative. During the period from 1952 to 1967, analyses of programs found a great deal of violence in them. Two governmental commissions investigated the problem of television violence in the late 1960s. Such studies led to an annual content analysis of television programs. They also resulted in a series of unresolved arguments and controversies. The public was not much interested in television violence for reasons not discernible. Citizen groups raised protests against various broadcasting practices. Information on trends in violence depends on the definitions of violence and on the analytic procedures used.
KW - VIOLENCE on television
KW - LEGISLATIVE hearings -- United States
KW - HUMAN sexuality on television
KW - GOVERNMENTAL investigations
KW - TELEVISION broadcasting -- United States
KW - UNITED States
KW - Experimental Study
KW - Psychological Factors Affecting Tension
KW - Tension and its Reduction; Conflict and its Resolutions
N1 - Accession Number: 11392918; Pearl, David 1; Affiliation: 1: Chief, Behavioral Sciences Research Branch, National Institute of Mental Health; Source Info: Sep/Oct84, Vol. 21 Issue 6, p17; Subject Term: VIOLENCE on television; Subject Term: LEGISLATIVE hearings -- United States; Subject Term: HUMAN sexuality on television; Subject Term: GOVERNMENTAL investigations; Subject Term: TELEVISION broadcasting -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Experimental Study; Author-Supplied Keyword: Psychological Factors Affecting Tension; Author-Supplied Keyword: Tension and its Reduction; Conflict and its Resolutions; NAICS/Industry Codes: 515120 Television Broadcasting; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KASID, ATTAN
AU - STROBL, JEANNINE S.
AU - HUFF, KAREN
AU - GREENE, GEOFFREY L.
AU - LIPPMAN, MARC E.
T1 - A Novel Nuclear Form of Estradiol Receptor in MCF-7 Human Breast Cancer Cells.
JO - Science
JF - Science
Y1 - 1984/09/14/
VL - 225
IS - 4667
M3 - Article
SP - 1162
EP - 1165
SN - 00368075
AB - Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to aform that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85680085; KASID, ATTAN 1 STROBL, JEANNINE S. 2 HUFF, KAREN 3 GREENE, GEOFFREY L. 4 LIPPMAN, MARC E. 3; Affiliation: 1: Medicine Branch, National Cancer Institute, Bethesda, Maryland 20205 2: Laboratory of Biochemistry, National Cancer Institute 3: Medicine Branch, National Cancer Institute 4: GEOFFREY L. GREENE Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637; Source Info: 9/14/1984, Vol. 225 Issue 4667, p1162; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - PURO, DONALD G.
AU - AGARDH, ELISABET
T1 - Insulin-Mediated Regulation of Neuronal Maturation.
JO - Science
JF - Science
Y1 - 1984/09/14/
VL - 225
IS - 4667
M3 - Article
SP - 1170
EP - 1172
SN - 00368075
AB - Exposure to insulin increased stimulus-evoked transmission at synapses formed in culture by cholinergic retinal neurons derived from fetal rats. This effect occurred at physiological concentrations and was long lasting. Thefindings support the hypothesis that insulin may serve as a developmental signal to regulate the emergence of effective neurotransmission across nascent synapses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85680089; PURO, DONALD G. 1 AGARDH, ELISABET 1; Affiliation: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 9/14/1984, Vol. 225 Issue 4667, p1170; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MITSUYA, HIROAKI
AU - POPOVIC, MIKULAS
AU - YARCHOAN, ROBERT
AU - MATSUSHITA, SHUZO
AU - GALLO, ROBERT C.
AU - BRODER, SAMUEL
T1 - Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III.
JO - Science
JF - Science
Y1 - 1984/10/12/
VL - 226
IS - 4671
M3 - Article
SP - 172
EP - 174
SN - 00368075
AB - A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692099; MITSUYA, HIROAKI 1 POPOVIC, MIKULAS 2 YARCHOAN, ROBERT 3 MATSUSHITA, SHUZO 3 GALLO, ROBERT C. 2 BRODER, SAMUEL 3; Affiliation: 1: Clinical Oncology Program, National Cancer Institute, Bethesda, Maryland 20205 2: Laboratory of Tumor Cell Biology, National Cancer Institute 3: Clinical Oncology Program, National Cancer Institute; Source Info: 10/12/1984, Vol. 226 Issue 4671, p172; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SOMERS, ROBERT L.
AU - KLEIN, DAVID C.
T1 - Rhodopsin Kinase Activity in the Mammalian Pineal Gland and Other Tissues.
JO - Science
JF - Science
Y1 - 1984/10/12/
VL - 226
IS - 4671
M3 - Article
SP - 182
EP - 184
SN - 00368075
AB - Rhodopsin kinase, an enzyrne involved in photochemical transduction in the retina, has been found in the mamtmalian pineal gland in amounts equal to those in the retina; other tissues had 7 percent of this armount, or less. Thisfinding suggests that, ini mammals, rhodopsin kinasefunctions in the pineal gland and other tissues to phosphorylate rhodopsin-like integral membrane receptors and is thereby involved in signal transduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692103; SOMERS, ROBERT L. 1 KLEIN, DAVID C. 2; Affiliation: 1: Section on Retinal Metabolism, Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20205 2: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 10/12/1984, Vol. 226 Issue 4671, p182; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06406-025
AN - 2006-06406-025
AU - Waxler, Carolyn Zahn
T1 - The Social Side of Social Cognition Discovered.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1984/11//
VL - 29
IS - 11
SP - 889
EP - 890
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06406-025. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Waxler, Carolyn Zahn; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychosocial Development; Social Cognition. Minor Descriptor: Cognitive Science; Social Interaction. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Higgins, E. Tory (Ed); Ruble, Diane N. (Ed); Hartup, Willard W. (Ed). Social Cognition and Social Development: A Sociocultural Perspective=Cambridge, England: Cambridge University Press, 1983. 425 pp. $39.50; 1983. References Available: Y. Page Count: 2. Issue Publication Date: Nov, 1984.
AB - Reviews the book, Social Cognition and Social Development: A Sociocultural Perspective edited by E. Tory Higgins, Diane N. Ruble, and Willard W. Hartup (1983). In this advanced and specialized text the editors attempt to integrate concepts and findings of social and cognitive science as they apply to (a) the development of children's social cognitions and (b) the relationships between social cognition and social behavior. The goal of exploring environmental forces that influence children's social cognitions, their social interactions, and the interconnections of their thought and behavior is admirable. The book's contributors represent diverse theoretical perspectives. This book helps to draw us to the edge of a new era in social cognition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social interactions
KW - social development
KW - social behavior
KW - cognitive science
KW - social cognition
KW - 1984
KW - Psychosocial Development
KW - Social Cognition
KW - Cognitive Science
KW - Social Interaction
KW - 1984
U2 - Higgins, E. Tory (Ed); Ruble, Diane N. (Ed); Hartup, Willard W. (Ed). (1983); Social Cognition and Social Development: A Sociocultural Perspective; Cambridge, England: Cambridge University Press, 1983. 425 pp. $39.50
DO - 10.1037/022397
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06406-025&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kaipainen, Pekka
AU - Nebert, Daniel W.
AU - Lang, Matti A.
T1 - Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/11/02/
VL - 144
IS - 3
M3 - Article
SP - 425
EP - 431
PB - Wiley-Blackwell
SN - 00142956
AB - Phenobarbital-induced coumarin 7-hydroxylase is high in DBA/2J and low in C57BL/6N inbred mice: this genetic difference is encoded by tide Coli locus on chromosome 7. The aim of this study was to develop art antibody specific for this cytochrome P-450 polymorphism. P-450 fractions, highly specific for phenobarbital-inducible coumarin 7-hydroxylase activity, were purified from DBA/2J and C57BL/6N mouse liver microsomes. Both proteins are 49 kDa. as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Soret peaks of the reduced cytochrome · CO complexes are 451 nm. Reconstituted DBA/2J coumarin 7-hydroxylase activity exhibits a V twice as high as, and a Km value 10-fold less than, the reconstituted C57BL/6N activity. Antibodies were raised in rabbit. By Ouchterlony immunodiffusion, both antibodies show 100% cross-reactivity with DBA/2J and C57BL/6N microsomes and purified antigens. Yet, DBA/2J but not C57BL/6N 7-hydroxylase activity is inhibited by the antibody to DBA/2J P-450. Both DBA/2J and C57BL/6N activities are blocked by the antibody to C57BL/6N P-450. Neither antibody has any effect on liver microsomal d-benzphetamine N-demethylase, ethylmorphine N-demethylase, aminopyrine N-demethylase. 7-ethoxycoumarin O-deethylase, acetanilide 4-hydroxylase, or aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity. The DBA/2J protein most specific for phenobarbital-induced coumarin 7-hydroxylation is designated ‘P-450Coh’. Anti-(P-450Coh) precipitates a relatively minor 49-kDa protein from detergent-solubilized microsomes and from in vitro translation of poly(A+)-enriched total RNA of phenobarbital-treated DBA/2J mouse liver, whereas the major phenobarbital-induced P-450 proteins exhibit a molecular mass of about 51 kDa. The immunoprecipitated translation products correspond to a messenger RNA of 2100±100 nucleotides. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - CYTOCHROMES
KW - MONOOXYGENASES
KW - METALLOENZYMES
KW - GENETIC polymorphisms
KW - BIOCHEMISTRY
KW - CHEMISTRY
N1 - Accession Number: 13833783; Kaipainen, Pekka 1 Nebert, Daniel W. 1 Lang, Matti A. 1; Affiliation: 1: Department of Physiology, University of Kuopio; Laboratory of Developmental Pharmacology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; and Department of Toxicology, University of Kuopio; Source Info: 11/2/84, Vol. 144 Issue 3, p425; Subject Term: CYTOCHROME P-450; Subject Term: CYTOCHROMES; Subject Term: MONOOXYGENASES; Subject Term: METALLOENZYMES; Subject Term: GENETIC polymorphisms; Subject Term: BIOCHEMISTRY; Subject Term: CHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Farmer, Mary E.
AU - White, Lon R.
AU - Brody, Jacob A.
AU - Bailey, Kent R.
T1 - Race and Sex Difference in Hip Fracture Incidence.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/12//
VL - 74
IS - 12
M3 - Article
SP - 1374
EP - 1380
PB - American Public Health Association
SN - 00900036
AB - Abstract: Incidence rates for hip fracture in the United States were estimated using non-federal hospital discharges from the National Hospital Discharge Survey for the years 1974-1979. Age-specific incidence curves for women and for men showed similar patterns of increase in risk with age, with risks approximately doubling every five years after age 50. Age-specific rates by five-year age groups were compared among the four race-sex groups. No significant differences were observed between Black females, Black males, and White males. In contrast, rates for White females were one and one-half to four limes those for Black females after age 40 and were approximately double those for White males alter age 50. Analysis based on an independent data source of non-federal hospital discharges in Washington, DC confirmed these relationships. In the Washington study, White women were at twice the risk for hip fracture (controlled for age) compared with Black women and at 2.7 times the risk for hip fracture (controlled for age) compared to White men. No significant differences were observed between Black women and Black men. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIP joint -- Dislocation
KW - OSTEOPOROSIS
KW - BONES -- Diseases
KW - POISSON distribution
KW - DISTRIBUTION (Probability theory)
KW - EPIDEMIOLOGY
KW - DISEASES -- Causes & theories of causation
KW - SEX differences (Biology)
KW - UNITED States
N1 - Accession Number: 4952157; Farmer, Mary E. 1 White, Lon R. 2 Brody, Jacob A. 3 Bailey, Kent R. 1; Affiliation: 1: Senior Staff Fellow, Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, Federal Building, Rm 612, Bethesda, MD 20205. 2: National Institute on Agineg, 3: Mathematica and Pllied Statics Branch, National Health Lung and Blood Institute.; Source Info: Dec1984, Vol. 74 Issue 12, p1374; Subject Term: HIP joint -- Dislocation; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Diseases; Subject Term: POISSON distribution; Subject Term: DISTRIBUTION (Probability theory); Subject Term: EPIDEMIOLOGY; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: SEX differences (Biology); Subject Term: UNITED States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brody, Jacob A.
AU - Farmer, Mary E.
AU - White, Lon R.
T1 - Absence of Menopausal Effect on Hip Fracture Occurrence in White Females.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/12//
VL - 74
IS - 12
M3 - Article
SP - 1397
EP - 1398
PB - American Public Health Association
SN - 00900036
AB - Abstract: The rate of hip fracture among White females rises sharply between ages 40 and 44 and then continues at a constant rate of acceleration doubling every five to six years throughout life with no deviation during, or in the years immediately following, menopause. We suggest that the important role of sex hormones and other factors in osteoporosis commences prior to menopause. A premenopause prevention strategy which postpones the onset of the osteoporotic process by live or six years would be expected to reduce the risk of hip fracture by 50 per ¢ throughout the remainder of a woman's life. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIP joint -- Dislocation
KW - SEX hormones
KW - MENOPAUSE
KW - OSTEOPOROSIS
KW - BONES -- Diseases
KW - BONE density
KW - WOMEN patients
KW - WOMEN -- United States
KW - UNITED States
N1 - Accession Number: 4952222; Brody, Jacob A. 1 Farmer, Mary E. 1 White, Lon R. 1; Affiliation: 1: Associate Director, Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, Biometry, Program, National Institute on Aging, National Institute of Health, Bethesds, MD 20205.; Source Info: Dec1984, Vol. 74 Issue 12, p1397; Subject Term: HIP joint -- Dislocation; Subject Term: SEX hormones; Subject Term: MENOPAUSE; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Diseases; Subject Term: BONE density; Subject Term: WOMEN patients; Subject Term: WOMEN -- United States; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slomczynski, Kazimierz M.
AU - Krauze, Tadeusz
T1 - SHOULD THE FRAMEWORK OF STRUCTURAL VS. CIRCULATION MOBILITY BE ABANDONED? IF SO, NOT BECAUSE OF FAULTY LOGIC.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1984/12//
VL - 49
IS - 6
M3 - Article
SP - 850
EP - 852
SN - 00031224
AB - In the article, the authors comment on the article "Structural Mobility, Circulation Mobility and Analysis of Occupational Mobility: A Conceptual Mismatch," by Michael E. Sobel, published in the October 1983 issue of the journal "American Sociological Review." According to the authors, Sobel has called for "abandonment of the structure vs. circulation framework" in social mobility studies. He claims that even under the correct interpretation of the intergenerational mobility table--that is, in terms of origin and destination distributions of sons-neither the models of statistical independence nor the traditional indices correctly account for structural and circulation mobility. Commenting on Sobel's conclusion, the authors show that its derivation is based on faulty logic, and therefore is inadmissible. Specifically, two logical fallacies are involved: hasty generalization and a non sequitur. Since Sobel defines circulation mobility residually, his focus is on evaluating solutions to the problem of accounting for structural mobility.
KW - SOCIAL structure
KW - OCCUPATIONAL mobility
KW - SOCIAL mobility
KW - SOCIOLOGY
KW - SOCIAL systems
KW - INTERGENERATIONAL relations
N1 - Accession Number: 14813330; Slomczynski, Kazimierz M. 1; Krauze, Tadeusz 2; Affiliations: 1: National Institute of Mental Health University of Warsaw, Poland; 2: Hofstra University; Issue Info: Dec84, Vol. 49 Issue 6, p850; Thesaurus Term: SOCIAL structure; Thesaurus Term: OCCUPATIONAL mobility; Subject Term: SOCIAL mobility; Subject Term: SOCIOLOGY; Subject Term: SOCIAL systems; Subject Term: INTERGENERATIONAL relations; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gottesman, Susan
T1 - BACTERIAL REGULATION: GLOBAL REGULATORY NETWORKS.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1984/12//
VL - 18
M3 - Article
SP - 415
EP - 441
PB - Annual Reviews Inc.
SN - 00664197
AB - Discusses the role of global regulatory networks in bacterial regulation. Components of the network which include stimulus and signal, regulatory proteins; Explanation of specific systems for SOS regulation, heat-shock response and SOS systems; Conclusions for the promoter structure and regulators.
KW - BIOLOGICAL control systems
KW - BACTERIA
KW - BACTERIOLOGY
KW - BIOLOGICAL systems
KW - BIOLOGY
N1 - Accession Number: 12345431; Gottesman, Susan 1; Affiliation: 1: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland; Source Info: 1984, Vol. 18, p415; Subject Term: BIOLOGICAL control systems; Subject Term: BACTERIA; Subject Term: BACTERIOLOGY; Subject Term: BIOLOGICAL systems; Subject Term: BIOLOGY; Number of Pages: 27p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHOMCZYNSKI, PIOTR
AU - QASBA, PRADMAN
AU - TOPPER, YALE J.
T1 - Essential Role of Insulin in Transcription of the Rat 25,000 Molecular Weight Casein Gene.
JO - Science
JF - Science
Y1 - 1984/12/14/
VL - 226
IS - 4680
M3 - Article
SP - 1326
EP - 1328
SN - 00368075
AB - Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation. of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692141; CHOMCZYNSKI, PIOTR 1 QASBA, PRADMAN 2 TOPPER, YALE J. 3; Affiliation: 1: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 2020S 2: Laboratory of Pathophysiology, National Cancer Institute, Bethesda, Maryland 20205 3: Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases; Source Info: 12/14/1984, Vol. 226 Issue 4680, p1326; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KENNEY, SHANNON
AU - NATARAJAN, VENKATACHALA
AU - STRIKE, DAVID
AU - KHOURY, GEORGE
AU - SALZMAN, NORMAN P.
T1 - JC Virus Enhancer-Promoter Active in Human Brain Cells.
JO - Science
JF - Science
Y1 - 1984/12/14/
VL - 226
IS - 4680
M3 - Article
SP - 1337
EP - 1339
SN - 00368075
AB - A human papovavirus, JCV, is the etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy. The JCV 98-base-pair tandem repeats, located to the late side of the viral replication origin, were shown to be a transcriptional regulatory element with enhancer-like activity in human fetal glial cells, These tandem repeats share significant homology with the 82-nucleotide rat brain-specific identifier RNA sequence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692146; KENNEY, SHANNON 1 NATARAJAN, VENKATACHALA 1 STRIKE, DAVID 1 KHOURY, GEORGE 1 SALZMAN, NORMAN P. 1; Affiliation: 1: Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 12/14/1984, Vol. 226 Issue 4680, p1337; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wiebel, Friedrich J.
AU - Sang Shin Park
AU - Kiefer, Franz
AU - Gelboin, Harry V.
T1 - Expression of cytochromes P-450 in rat hepatoma cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1984/12/17/
VL - 145
IS - 3
M3 - Article
SP - 455
EP - 462
PB - Wiley-Blackwell
SN - 00142956
AB - We have studied the expression of aldrin epoxidase (AE), 7-ethoxycoumarin-O-deethylase (ECDE), and aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH) in nine differentiated or dedifferentiated cell lines derived from H4IIEC3 rat hepatoma cells. The nature of the cytochromes P-450 mediating AE, ECDE and AHH activities was analysed using monoclonal antibodies (MAb) made to the major 3-methylcholanthrene-induced cytochrome P-450 (MAb-MC) or phenobarbital-induced cytochrome P-450 (MAb-PB) from rat liver. The cells were treated with 5 μM dexamethasone for 30 h to increase the levels of the monooxygenase activities. (a) The six differentiated cell lines examined (Faza967, Fao, HF1–4, 2sFou, C2Rev7, and H4IIEC3/G-) contained MAb-PB-sensitive AE comprising 30–75% of the total AE activity. In most of these cell lines MAb-PB also markedly inhibited ECDE; however, the antibody had a considerably weaker effect on AHH. (b) MAb-PB-sensitive AHH, ECDE and AE activities were also observed in untreated and phenobarbital-treated ceils. (c) MAb-MC inhibited AHH and ECDE in the two dedifferentiated lines HF1 and H5 by 50–80%. The antibody also inhibited AHH activities in the poorly differentiated line H41IEC3/T and in the majority of the differentiated lines by 40–65%. MAb-MC-sensitive AHH was found in Fao cells after treatment with benz[a]anthracene but not with dexamethasone. C2Rev7 cells did not contain detectable MAb-MC-sensitive AHH. (d) Benz[a]anthracene induced AHH in H4IIEC3/T, H4IIEC3/G-, and 2sFou cells 20–30-fold and in Faza967 and Fao cells 3–5-fold. Benz[a]anthracene remained without effect on AHH activity in C2Rev7 cells. various degrees phenobarbital-inducible The results show that the hepatoma cells examined express to cytochrome P-450 and/or 3-methylcholanthrene-inducible cytochrome P-450. These cell lines are versatile tools for studying the regulation of monooxygenase activities and analysing their role in the activation and inactivation of xenobiotics such as carcinogens, drugs and pesticides. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - MONOOXYGENASES
KW - ALDRIN
KW - HYDROCARBONS
KW - HEPATOMA
KW - CANCER cells
KW - MONOCLONAL antibodies
N1 - Accession Number: 13831977; Wiebel, Friedrich J. 1 Sang Shin Park 1 Kiefer, Franz 1 Gelboin, Harry V. 1; Affiliation: 1: Institut für Toxikologie und Biochemie, Abteilung für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg; and Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: 12/17/84, Vol. 145 Issue 3, p455; Subject Term: CYTOCHROME P-450; Subject Term: MONOOXYGENASES; Subject Term: ALDRIN; Subject Term: HYDROCARBONS; Subject Term: HEPATOMA; Subject Term: CANCER cells; Subject Term: MONOCLONAL antibodies; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - Gen
ID - 9999-07723-000
AN - 9999-07723-000
AU - Hunter, Fumiyo Tao
T1 - Adolescent Conversation Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1985///
AD - Hunter, Fumiyo Tao, National Institute of Child Health and Human Development, Child and Family Research Section, Building 31, Room B2B15, Bethesda, Maryland, United States, 20205
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: Unknown. Test Items: Yes
N1 - Accession Number: 9999-07723-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institute of Child Health and Human Development, Child and Family Research Section, Bethesda, Maryland, United States. Release Date: 20111212. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: The rating categories were: We don't discuss this topic (1), not often (2), sometimes (3), and often (4).. Language: English. Constructs: Communication Patterns; Classification: Development and Aging (5800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Adolescent Conversation Questionnaire is to assess patterns of communication between adolescents and their parents and friends.
AB - Description: The Adolescent Conversation Questionnaire (Hunter, 1984) was developed within the context of a study that examined adolescents' perceptions of discussions with parents and friends with reference to the academic/vocational, social/ethical, family, and peer domains. A total of 180 subjects completed a paper-and-pencil questionnaire: 30 males and 30 females represented each of three age groups: 12-13-, 14-15-, and 18-20- year-olds. The questionnaire contained three identical sections, each referring to father, mother, or a friend. Each section began with a question referring to the seven topics of conversation that followed. For each of the seven items, subjects rated (a) how often their fathers (mothers, friends) explain reasons for their ideas and (b) how often their fathers (mothers, friends) try to understand their ideas. The following four scales were computed: academic/vocational issues (Items 1 and 3), social/ethical issues (Items 6 and 7), family relationships (Item 5), and peer relationships (Items 2 and 4). computed for the explanation and understanding scores for three scales and three relationships. They ranged from .24 to .65, with 11 of 18 being above .40. Three scales— explanation by mothers about academic/vocational topics, explanation by friends about friendship topics, and explanation by mothers about social/ethical topics—had reliabilities of .35 or below. Discussion levels for parents remained substantial across ages in the academic/vocational, social/ethical, and family domains. Discussions with friends about these domains increased with age, and peer relationship issues were discussed more with friends than with parents in all age groups. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Adolescent Conversation Questionnaire
KW - Social Attitudes
KW - Test Development
U5 - Adolescent Conversation Questionnaire [Test Development]Adolescents' perception of discussions with parents and friends. (AN: 1985-25202-001 from PsycINFO) Hunter, Fumiyo T.; May, 1985. Source: Developmental Psychology. 21(3), American Psychological Association, US; May, 1985; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Adolescents (Ages 12-20); Location: United States Keywords: Adolescent Conversation Questionnaire; Social Attitudes; Test Development; Subjects: Adolescent Attitudes; Adolescent Development; Conversation; Parent Child Communication; Peer Relations; Psychosocial Development; Questionnaires; Test Construction;
DO - 10.1037/t07723-000
L3 - Full; Full text; 999907723_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-12108-000
AN - 9999-12108-000
AU - McCrae, Robert R.
AU - Costa, Paul T. Jr.
T1 - Bipolar Adjective Rating Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1985///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-12108-000. Partial author list: First Author & Affiliation: McCrae, Robert R.; National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland, United States. Release Date: 20120611. Correction Date: 20160808. Instrument Type: Rating Scale. Test Format: Eighty adjective pairs are rated on a 9-point scale.. Language: English. Constructs: Personality; Classification: Personality (7200). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the scale is to assess personality traits based on the Norman's (1963) five-factor model as well as the Neuroticism, Extraversion, Openness (NEO) model.
AB - Description: The Bipolar Adjective Rating Scale (McCrae & Costa, 1985) assesses personality traits based on the Norman's (1963) five-factor model as well as the Neuroticism, Extraversion, Openness (NEO) model. It consists of 80 adjective pairs, with 8 pairs each measuring the five factors of Extraversion or Surgency; Agreeableness; Emotional Stability vs. Neuroticism; Culture; and Conscientiousness (from the Five-Factor Model), 8 pairs each measuring Neuroticism, Extraversion, and Openness (from the NEO Model), and additional items for agreeableness and conscientiousness, suggested by an analysis of longer lists of adjectives reported by Goldberg (1980). Adjective pairs are rated on a 9-point scale. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Bipolar Adjective Rating Scale
KW - Test Development
KW - Five-Factor Model
KW - Personality Traits
U5 - Bipolar Adjective Rating Scale [Test Development]Updating Norman's "adequacy taxonomy": Intelligence and personality dimensions in natural language and in questionnaires. (AN: 1986-03750-001 from PsycINFO) McCrae, Robert R.; Costa, Paul T.; Sep, 1985. Source: Journal of Personality and Social Psychology. 49(3), American Psychological Association, US; Sep, 1985; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older), Very Old (85 yrs & older); Population: Human; Male; Female; Sample: Community-Dwelling Volunteers (Ages 24-89); Location: United States Keywords: Bipolar Adjective Rating Scale; Test Development; Five-Factor Model; Personality Traits; Subjects: Adjectives; Five Factor Personality Model; Personality Traits; Rating Scales; Test Construction;
DO - 10.1037/t12108-000
L3 - Full; Full text; 999912108_full_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-12108-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-19441-000
AN - 9999-19441-000
AU - Hunter, Fumiyo Tao
T1 - Unilateral and Mutual Interactions with Parents and Peers Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1985///
AV - Commercial: No; Permissions: Contact Publisher; Fee: No
N1 - Accession Number: 9999-19441-000. Partial author list: First Author & Affiliation: Hunter, Fumiyo Tao; National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland, United States. Release Date: 20130311. Test Format: Each question is followed by 4 unilateral and 4 mutual response statements. The 32 response items are repeated in father, mother, and friend sections. Subjects rate, on a scale of 1 (Hardly Ever) to 4 (Very Often), how often the interactions described under Questions 1 and 3 occur in their interactions with parents and friends. The items under Questions 2 and 4 are rated as 1 (Not the Reason at All) to 4 (My Main Reason).. Language: English. Constructs: Adolescent Interactions; Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320).
AB - Purpose: The purpose of this scale is to examine how adolescents experience the interplay of interactions with mothers, fathers, and friends.
AB - Description: A Unilateral and Mutual Interactions with Parents and Peers Questionnaire was developed by Hunter in 1985. It was constructed in a study examining how individual adolescents experience the interplay of interactions with mothers, fathers, and friends. Participants were adolescents in the 12-13, 14-15, and 18- 20 year range. The questionnaire consisted of 4 questions, each followed by 4 unilateral and 4 mutual response statements. The unilateral items described the other person (a parent or a friend) as expecting compliance or giving advice based on greater expertise and didactic concerns. The mutual items represented the other person negotiating or sharing problem solving based on common interests, problems, and uncertainties. The 32 response items were repeated in father, mother, and friend sections, with the appropriate changes of wording and personal pronouns. Unilateral and mutual scale scores were computed as unweighted averages of 16 items each; 3 sets of unilateral and mutual scores were calculated for father, mother, and friend data. The Cronbach's alphas for the unilateral items were .80, .77, and .72 for the father, mother, and friend scales, respectively. The corresponding alphas for the mutual items were .82, .77, and .80.
KW - Internal Consistency
KW - Test Development
KW - Unilateral and Mutual Interactions with Parents and Peers Questionnaire
U5 - Unilateral and Mutual Interactions with Parents and Peers Questionnaire [Test Development]Individual adolescents' perceptions of interactions with friends and parents. (AN: 1986-29706-001 from PsycINFO) Hunter, Fumiyo T.; Fal, 1985. Source: The Journal of Early Adolescence. 5(3), Sage Publications, US; Fal, 1985; Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs), Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Location: United States; Sample: Adolescents Keywords: Internal Consistency; Test Development; Unilateral and Mutual Interactions with Parents and Peers Questionnaire; Subjects: Aptitude Measures; Friendship; Interpersonal Interaction; Parent Child Relations; Test Reliability;
DO - 10.1037/t19441-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-19441-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-26705-000
AN - 9999-26705-000
AU - Secunda, Steven K.
AU - Katz, Martin M.
AU - Swann, Alan
AU - Koslow, Stephen H.
AU - Maas, James W.
AU - Chuang, Sidney
AU - Croughan, Jack
T1 - Manic Diagnostic and Severity Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1985///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-26705-000. Other Names: Mania Diagnostic and Severity Scale. Acronyms: MADS. Partial author list: First Author & Affiliation: Secunda, Steven K.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20140210. Correction Date: 20151109. Instrument Type: Rating Scale. Test Location: Appendix 2, Page 120; Appendix 1, Page 120. Test Format: Physicians/nurses provide ratings for each of the 23 descriptors.. Language: English. Constructs: Mania; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380).
AB - Purpose: The purpose of the Manic Diagnostic and Severity Scale is to provide a composite measure of manic symptoms. It represents a combining of previously validated tests in order to obtain greater breadth and sensitivity in diagnosis and in the assessment of severity and change.
AB - Description: The Manic Diagnostic and Severity Scale (MADS; Secunda et al., 1985) assesses mania by integrating subscales from three established measures: 1. Schedule of Affective Disorders and Schizophrenia (SADS; Spitzer & Endicott, 1978), 2. Video Interview Behavior Evaluation Scale (VIBES; Katz & Itil, 1974), and 3. Affective Disorder Rating Scale (ADRS; Murphy, Pickar, & Alterman, 1980). To measure the symptoms characteristic of mania as judged by the clinician, the 5-item SADS-C-17 scale is used. It provides a profile of the major manic features and would appear to represent a core syndrome for mania. It contains elements which correspond more to the elation-grandiose (E-G) index proposed by Beigel and Murphy (1971). The 6-item, physician-rated VIBES Factor B-2 Scale is used to emphasize the angry and negative side of the syndrome, and corresponds with Beigel and Murphy's (1971) paranoid-destructive (P-D) characterization. Two factors are derived from the nurse-rated ADRS: 1. Factor 1 (9 items), which describes a manic syndrome weighted with P-D elements and 2. Factor 2 (3 items), which describes an E-G subtype. These four factors are 'summed' to create a severity score for the MADS. Using a sample of manic patients, interrater reliability was found to be high. The MADS also demonstrated evidence of discriminant validity and sensitivity to change. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Affective Disorder Rating Scale
KW - Discriminant Validity
KW - Inter-Rater Reliability
KW - Manic Diagnostic and Severity Scale
KW - Schedule of Affective Disorders and Schizophrenia
KW - Video Interview Behavior Evaluation Scale
KW - Test Development
KW - Rating Scales
U5 - Manic Diagnostic and Severity Scale (MADS) [Test Development]Mania: Diagnosis, state measurement and prediction of treatment response. (AN: 1986-06597-001 from PsycINFO) Secunda, Steven K.; Katz, Martin M.; Swann, Alan; Koslow, Stephen H.; Maas, James W.; Chuang, Sidney; Croughan, Jack; Mar-Apr, 1985. Source: Journal of Affective Disorders. 8(2), Elsevier Science, Netherlands; Mar-Apr, 1985; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Age Range: 23-74 Years; Sample: Manic Patients Keywords: Affective Disorder Rating Scale; Discriminant Validity; Inter-Rater Reliability; Manic Diagnostic and Severity Scale; Schedule of Affective Disorders and Schizophrenia; Video Interview Behavior Evaluation Scale; Test Development; Subjects: Bipolar Disorder; Mania; Medical Diagnosis; Severity (Disorders); Test Construction; Test Reliability; Test Validity;
U5 - Manic Diagnostic and Severity Scale (MADS) [Test Use]Specificity of mixed affective states: Clinical comparison of dysphoric mania and agitated depression. (AN: 1993-45473-001 from PsycINFO) Swann, Alan C.; Secunda, Steven K.; Katz, Martin M.; Croughan, Jack; Bowden, Charles L.; Koslow, Stephen H.; Berman, Nancy; Stokes, Peter E.; Jun, 1993. Source: Journal of Affective Disorders. 28(2), Elsevier Science, Netherlands; Jun, 1993; Population: Human; Inpatient; Sample: Mixed (Dysphoric) Manics; Agitated Depressed Patients Keywords: Affective Disorder Rating Scale; Discriminant Validity; Inter-Rater Reliability; Manic Diagnostic and Severity Scale; Schedule of Affective Disorders and Schizophrenia; Video Interview Behavior Evaluation Scale; Rating Scales; Subjects: Bipolar Disorder; Mania; Medical Diagnosis; Rating Scales; Severity (Disorders); Test Reliability; Test Validity;
DO - 10.1037/t26705-000
L3 - Full; Full text; 999926705_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Naoi, Atsushi
AU - Schooler, Carmi
T1 - Occupational Conditions and Psychological Functioning in Japan.
JO - American Journal of Sociology
JF - American Journal of Sociology
Y1 - 1985/01//
VL - 90
IS - 4
M3 - Article
SP - 729
EP - 752
SN - 00029602
AB - Compares working conditions in Japan and the United States and tests whether the reciprocal effects of occupational conditions and psychological functioning in Japan are similar to those found in the United States.
KW - OCCUPATIONAL prestige
KW - AUTONOMY (Psychology)
KW - EMPLOYEES
KW - WORK environment
KW - SOCIAL psychology
KW - JAPAN
KW - UNITED States
N1 - Accession Number: 15648833; Naoi, Atsushi 1,2; Schooler, Carmi 2; Affiliations: 1 : University of Osaka, University of Tokyo; 2 : U.S. National Institute of Mental Health; Source Info: Jan85, Vol. 90 Issue 4, p729; Historical Period: 1974 to 1980; Subject Term: OCCUPATIONAL prestige; Subject Term: AUTONOMY (Psychology); Subject Term: EMPLOYEES; Subject Term: WORK environment; Subject Term: SOCIAL psychology; Subject: JAPAN; Subject: UNITED States; Number of Pages: 24p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=15648833&site=ehost-live&scope=site
DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Eil, Charles
AU - Cutler, Jr., Gordon B.
AU - Loriaux, D. Lynn
T1 - Androgen Receptor Characteristics in Skin Fibroblasts from Hirsute Women.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/01//
VL - 84
IS - 1
M3 - Article
SP - 62
EP - 65
SN - 0022202X
AB - Hormonal measurements in some women with hirsutism often reveal little or no elevation in androgen levels to explain the disorder. Thus, it has been postulated that increased sensitivity of the hair follicle to androgen may contribute to the development of hirsutism in such patients. We, therefore, sought androgen receptor abnormalities in skin fibroblasts cultured from 10 hirsute women (ages 17-43) and normal or mildly elevated plasma testosterone levels (28-82 ng/dl). Androgen receptor content (Ro) and binding affinity (Kd) in cultured pubic skin fibroblasts were measured using a dispersed, whole cell assay. Ten such cell lines from these women were compared with 19 pubic skin cell lines from 9 normal volunteers (6 males and 3 females) and from 10 other subjects (males with gynecomastia or hypospadias). There was no statistically significant difference in the mean androgen receptor content (11,600 ± 2700 (SE) sites/cell fibroblasts vs 7900 ± 700 sites/cell or binding affinity (2.0 ± 0.3 (SE) × 10[sup-9] M vs 1.5 ± 0.2 × 10-9 M, respectively) between the patients' fibroblasts and those of the controls. We conclude that hirsutism cannot be explained by abnormalities in fibroblast androgen receptor number or affinity. These observations do not exclude the possibility that other mechanisms might lead to increased peripheral androgen sensitivity in such patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROGENS
KW - HYPERTRICHOSIS
KW - WOMEN
KW - SKIN
KW - FIBROBLASTS
KW - HAIR follicles
KW - PATIENTS
N1 - Accession Number: 12274829; Eil, Charles 1 Cutler, Jr., Gordon B. Loriaux, D. Lynn 1; Affiliation: 1: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jan1985, Vol. 84 Issue 1, p62; Subject Term: ANDROGENS; Subject Term: HYPERTRICHOSIS; Subject Term: WOMEN; Subject Term: SKIN; Subject Term: FIBROBLASTS; Subject Term: HAIR follicles; Subject Term: PATIENTS; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12274829
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12274829&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morgan, B.L.G.
AU - Kuyatt, B.L.
AU - Fink, J.
T1 - Effects of hypothyroidism on the DNA, carbohydrate, soluble protein and sialic acid contents of rat submandibular glands.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1985/01//
VL - 14
IS - 1
M3 - Article
SP - 37
EP - 41
SN - 03009777
AB - Submandibular glands are a target organ of thyroid hormones. This study examine the effects of hypothyroidism on the biochemical characteristics of these glands in the rat. There were no effects on the neutral sugar and DNA contents. However, soluble protein concentrations (µg/mg wet weight) were significantly decreased and sialic acid concentrations µ/mg soluble protein) were significantly elevated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPOTHYROIDISM
KW - DNA
KW - SUBMANDIBULAR gland
KW - SIALIC acids
KW - PROTEINS
KW - CARBOHYDRATES
KW - RATS
N1 - Accession Number: 11478906; Morgan, B.L.G. 1 Kuyatt, B.L. 1 Fink, J. 1; Affiliation: 1: Division of Preventive Dentistry, Columbia University and Laboratory of Molecular Aging, National Institutes of Health, USA; Source Info: Jan85, Vol. 14 Issue 1, p37; Subject Term: HYPOTHYROIDISM; Subject Term: DNA; Subject Term: SUBMANDIBULAR gland; Subject Term: SIALIC acids; Subject Term: PROTEINS; Subject Term: CARBOHYDRATES; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1600-0714.ep11478906
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-05165-001
AN - 2009-05165-001
AU - Mirsky, Allan F.
T1 - Addendum: Bringing the Israeli high-risk study to completion.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1985///
VL - 11
IS - 1
SP - 30
EP - 30
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2009-05165-001. Partial author list: First Author & Affiliation: Mirsky, Allan F.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Nature Nurture; Schizophrenia. Minor Descriptor: Evolutionary Psychology; Scientific Communication. Classification: Schizophrenia & Psychotic States (3213). Page Count: 1. Issue Publication Date: 1985.
AB - The project discussed in the preceding introduction and as detailed by various authors in the subsequent articles was a natural evolution of David Rosenthal's scientific study of the nature-nurture issue in the development of schizophrenia. Rosenthal's genius in developing fruitful research designs in the study of schizophrenia is evident throughout this issue of the Schizophrenia Bulletin. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - natural evolution
KW - nature-nurture
KW - David Rosenthal
KW - schizophrenia development
KW - scientific communication
KW - 1985
KW - Nature Nurture
KW - Schizophrenia
KW - Evolutionary Psychology
KW - Scientific Communication
KW - 1985
DO - 10.1093/schbul/11.1.30
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05165-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05168-001
AN - 2009-05168-001
AU - Silberman, Edward K.
AU - Mirsky, Allan F.
T1 - The NIMH-Israeli Schizophrenia Project: The history of a high-risk study.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1985///
VL - 11
IS - 1
SP - 146
EP - 149
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C-110, Bethesda, MD, US, 20205
N1 - Accession Number: 2009-05168-001. PMID: 3983574 Partial author list: First Author & Affiliation: Silberman, Edward K.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Experimentation; Longitudinal Studies; Methodology; Schizophrenia. Classification: Research Methods & Experimental Design (2260); Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Israel. Page Count: 4. Issue Publication Date: 1985.
AB - We have reviewed some of the difficulties encountered in bringing this study to completion. Among our special problems were the necessity of collecting large numbers of measures on a relatively small study population, the need to recruit and maintain a staff over long periods of time, the wide geographical separation between staff members responsible for design and those responsible for execution of the study, and the difficulties of conducting longitudinal research in a politically unstable part of the world. Centralization of data and data analysis proved a crucial step in bringing the study to its present level of completion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NIMH-Israeli Schizophrenia Project
KW - high risk populations
KW - longitudinal studies
KW - research methods
KW - study limitations
KW - 1985
KW - At Risk Populations
KW - Experimentation
KW - Longitudinal Studies
KW - Methodology
KW - Schizophrenia
KW - 1985
DO - 10.1093/schbul/11.1.146
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05168-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09756-007
AN - 2005-09756-007
AU - Breznitz, Shlomo
T1 - Chores as a Buffer Against Risky Interaction.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1985///
VL - 11
IS - 3
SP - 357
EP - 360
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Breznitz, Shlomo, NIMH, Parklawn Bldg., Rm. 14C-02, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09756-007. Partial author list: First Author & Affiliation: Breznitz, Shlomo; National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060123. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Child Care; Kibbutz; Mental Disorders; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: 1985.
AB - Comments on the National Institute of Mental Health-Israeli high-risk study on children of schizophrenics (SZs), examining the unexpected finding that kibbutz (KB)-reared index Ss showed a higher incidence of psychiatric disorders than their family-reared counterparts. This finding suggests that there is an interaction between the developmental sequence from premorbid to morbid states and some environmental factors associated with the KB environment. It is hypothesized that as long as the SZ parent is able to carry out his/her instrumental role vis-a-vis the child, the relatively simple repetitious chores shield the interaction from drifting into possibly more disturbing patterns. Instead of trying to touch briefly on the many facets of this research, I chose to concentrate on a single, but most intriguing aspect of the results. Specifically, I wish to consider the unexpected finding that at the time of the last followup, kibbutz-reared index subjects (born to a schizophrenic parent) showed a higher incidence of psychiatric disorders than their cityreared counterparts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - kibbutz
KW - schizophrenia
KW - schizophrenic parents
KW - psychiatric disorders
KW - child care
KW - 1985
KW - Child Care
KW - Kibbutz
KW - Mental Disorders
KW - Schizophrenia
KW - 1985
DO - 10.1093/schbul/11.3.357
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09756-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09756-011
AN - 2005-09756-011
AU - Gibbons, Robert D.
AU - Lewine, Richard R. J.
AU - Davis, John M.
AU - Schooler, Nina R.
AU - Cole, Jonathan O.
T1 - An Empirical Test of a Kraepelinian vs. a Bleulerian View of Negative Symptoms.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1985///
VL - 11
IS - 3
SP - 390
EP - 396
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Gibbons, Robert D., Illinois State Psychiatric Institute, 1601 West Taylor St., Rm. 529 West, Chicago, IL, US, 60612
N1 - Accession Number: 2005-09756-011. PMID: 4035302 Partial author list: First Author & Affiliation: Gibbons, Robert D.; Department of Biostatistics, University of Illinois, Chicago, IL, US. Other Publishers: Oxford University Press. Release Date: 20060123. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Positive and Negative Symptoms; Psychiatric Symptoms. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Inpatient Multidimensional Psychiatric Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 1985.
AB - Confirmatory factor analysis was used to test a Kraepelinian vs. a Bleulerian interpretation of negative symptoms. The former focuses on absolute loss of functioning, while the latter emphasizes the qualitative loss of organization. Contrary to expectation, neither theory was confirmed, but rather three independent factors emerged: apathy, psychomotor retardation, and loss of goal. The implications of these findings for subtyping schemes and the conceptualization of negative symptoms are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - negative symptoms
KW - Kraepelinian interpretation
KW - Bleulerian interpretation
KW - 1985
KW - Positive and Negative Symptoms
KW - Psychiatric Symptoms
KW - 1985
DO - 10.1093/schbul/11.3.390
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09756-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Witschi, H. P.
AU - Tryka, A. F.
AU - Mauderly, J. L.
AU - Haschek, W. M.
AU - Satterfield, L. C.
AU - Bowles, N. D.
AU - Boyd, M. R.
T1 - Long‐term effects of repeated exposure to 3‐methylfuran in hamsters and mice.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1985/01/02/
VL - 16
IS - 3/4
M3 - Article
SP - 581
EP - 592
SN - 00984108
AB - Male and female Syrian golden hamsters were exposed for 2 h once a week for 10 consecutive weeks to 344 μmol/l of 3‐methylfuran (3MF), an agent known to produce acute Clara‐cell necrosis. Ten months later their respiratory function was evaluated. No functional differences were found between control and treated animals, and his‐topathologic evaluation of the lungs did not reveal any major treatment‐related alterations. Male and female BALB/c mice were exposed for 1 h to 26.8 μmol/l of 3MF once weekly for 10 wk. After 2 yr the tumor incidence in exposed animals was not increased when compared to controls. It is concluded that the acute Clara‐cell necrosis produced by 3MF at the doses used is of little long‐term consequence. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457213; Witschi, H. P. 1 Tryka, A. F. 2,3 Mauderly, J. L. 4 Haschek, W. M. 5,6 Satterfield, L. C. 5 Bowles, N. D. 5 Boyd, M. R. 7; Affiliation: 1: Biology Division, Oak Ridge National Laboratory, P. O. Box Y, Oak Ridge, Tennessee, 37831 2: Department of Pathology, Memorial Research Center, University of Tennessee, Knoxville, Tennessee 3: University of Arkansas for the Medical Sciences, Little Rock, Arkansas, 72203 4: Inhalation Toxicology Research Institute, Albuquerque, New Mexico 5: Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 6: College of Veterinary Medicine, University of Illinois, Urbana, Illinois, 61801 7: Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland; Source Info: Jan1985, Vol. 16 Issue 3/4, p581; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287398509530765
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DERSE, DAVID
AU - CARADONNA, SALVATORE J.
AU - CASEY, JAMES W.
T1 - Bovine Leukemia Virus Long Terminal Repeat: A Cell Type-Specific Promoter.
JO - Science
JF - Science
Y1 - 1985/01/18/
VL - 227
IS - 4684
M3 - Article
SP - 317
EP - 320
SN - 00368075
AB - The functional activity of the promoter unit contained within the long terminal repeat (LTR) of bovine leukemia virus (BLV) was examined by monitoring transient expression of a heterologous gene placed under its control. Various cell lines were transfected with recombinant plasmids carrying the bacterial chloramphenicol acetyltransferase (CAT) gene coupled to the BLV LTR (pBL-cat). Transient expression of CAT activity directed by the BLV LTR was observed only in the established BLV-producer cell lines derived from fetal lamb kidney (FLK) cells and bat lung cells. The amount of CAT activity transiently expressed in FLK-BLV cells was decreased approximately tenfold by deletion of LTR sequences located within a region 100 to 170 nucleotides upstream of the RNA start site. Surprisingly, removal of the region 50 base pairs downstream of the RNA initiation site to the 3'- end of the LTR reduced the expression of CAT activity by 87 percent. The BLV LTR thus appears to be an unusual promoter unit, functioning in a cell type-specific manner and possessing sequences on both the 5' and 3' sides of the RNA start site that influence gene expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461107; DERSE, DAVID 1 CARADONNA, SALVATORE J. 2 CASEY, JAMES W. 3; Affiliation: 1: Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701 2: Department of Pharmacology, Louisiana State University Medical Center, New Orleans 70112 3: Section of Genetics, Laboratory of Viral Carcinogenesis; Source Info: 1/18/1985, Vol. 227 Issue 4684, p317; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hintner, Helmut
AU - Neises, Gabrielle R.
AU - Lawley, Thomas J.
T1 - Immunologic Properties of Enzymatically Degraded Human Keratin Intermediate Filaments.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/02//
VL - 84
IS - 2
M3 - Article
SP - 108
EP - 113
SN - 0022202X
AB - In order to gain insight into the metabolism of keratin intermediate filaments (KIF) as well as the ability of KIF degradation products to interact with the immune system, we performed enzymatic degradation of purified KIF and examined their interaction with anti-KIF autoantibodies and their ability to act as immunogens. Aliquots of KIF aggregates were exposed to 3 different enzymes, that is, α-chymotrypsin, plasmin, and trypsin, in dose- and time-dependent experiments. The effect of the digestion was monitored sequentially by polyacrylamide gel electrophoresis and simultaneously by transmission electron microscopy. Furthermore the KIF degradation proteins were then examined for their ability to bind anti-KIF autoantibodies by immunoblot and for their immunogenicity. In addition, preincubation of KIF with anti-KIF autoantibodies prior to the digestion procedure was performed to investigate a possible protective effect of this treatment against proteolytic degradation. The experiments demonstrated that: (1) KIF are degraded by serine proteinases, (2) with prolonged incubation time intact KIF are progressively replaced by more granular-amorphous material in transmission electron microscopy, (3) anti-KIF autoantibodies bind to KIF degradation proteins, (4) preincubation of KIF with anti-KIF autoantibodies does not exert any major protective effect for KIF against proteolytic degradation, and (5) the enzymatic degradation products of KIF can function as effective immunogens causing the formation of high-titer anti-KIF antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATIN
KW - CYTOPLASMIC filaments
KW - IMMUNE system
KW - CHYMOTRYPSIN
KW - PLASMIN
KW - IMMUNOLOGY
N1 - Accession Number: 12275037; Hintner, Helmut 1 Neises, Gabrielle R. 1 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb85, Vol. 84 Issue 2, p108; Subject Term: KERATIN; Subject Term: CYTOPLASMIC filaments; Subject Term: IMMUNE system; Subject Term: CHYMOTRYPSIN; Subject Term: PLASMIN; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12275037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hofferth, Sandra L.
T1 - Updating Children's Life Course.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1985/02//
VL - 47
IS - 1
M3 - Article
SP - 93
SN - 00222445
AB - Dramatic changes have occurred in children's family experiences, and these changes are even more dramatic when actual living arrangements, not just parental marital statuses, are considered. According to data from the Panel Study of Income Dynamics, by age 17, 19% of white children born in 1950-1954 had lived with only one parent. By age 17, 70% of white children born in 1980 are projected to have spent at least some time with only one parent before they reach age 18. The proportion was 48% for black children born in 1950-1954 and is projected to be 94% for black children born in 1980. Of course, these figures do not indicate the actual proportion of their lives children spend in various family types. White children born in 1950-1954 could expect to spend 8% of their childhood with only one parent, black children 22%. Of those children born in 1980, white children can be expected to spend 31 % of their childhood years with one parent, black children 59%. Children's experience depends on family type at birth. Sixty-four percent of white children born in 1980 into a first-marriage family could expect to live at some point in a one-parent family by age 17; they could expect to spend 25% of their childhood in such a family. The comparable figures are 89% and 44% for black children born in the same year. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD rearing
KW - FAMILIES
KW - INCOME
KW - DOMESTIC relations
KW - MARITAL status
N1 - Accession Number: 5274667; Hofferth, Sandra L. 1; Affiliation: 1: National Institute of Child Health and Human Development.; Source Info: Feb85, Vol. 47 Issue 1, p93; Subject Term: CHILD rearing; Subject Term: FAMILIES; Subject Term: INCOME; Subject Term: DOMESTIC relations; Subject Term: MARITAL status; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Charon, J. A.
AU - Mergenhagen, S. E.
AU - Gallin, J. I.
T1 - Gingivitis and oral ulceration in patients with neutrophil dysfunction.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1985/02//
VL - 14
IS - 2
M3 - Article
SP - 150
EP - 155
SN - 03009777
AB - In this study, the gingival condition of patients with neutrophil dysfunction has been evaluated. The data demonstrate increased gingival disease as well as oral ulcerations in patients with neutrophil dysfunction syndromes and are consistent with a critical role of neutrophils in oral health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINGIVITIS
KW - NEUTROPHILS
KW - MOUTH -- Ulcers
KW - SYNDROMES
KW - ORAL diseases
N1 - Accession Number: 11541125; Charon, J. A. 1 Mergenhagen, S. E. 1 Gallin, J. I. 1; Affiliation: 1: Cellular Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research and the Bacterial Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, USA; Source Info: Feb85, Vol. 14 Issue 2, p150; Subject Term: GINGIVITIS; Subject Term: NEUTROPHILS; Subject Term: MOUTH -- Ulcers; Subject Term: SYNDROMES; Subject Term: ORAL diseases; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0714.ep11541125
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rölla, Gunnar
AU - Little, Wayne A.
AU - Ciardi, Joseph E.
T1 - Effect of antibody preparations on glucose uptake by a cariogenic streptococcus.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1985/02//
VL - 93
IS - 1
M3 - Article
SP - 13
EP - 16
SN - 0029845X
AB - The effect of antisera to whole cells or cell wall components on glucose uptake by S. mutans 6715 was examined. Early stationary phase 6715 cells were treated with test serum and incubated at 37°C in the presence of 14C-glucose. Samples were removed at timed intervals and measured in a liquid scintillation counter for radioactive uptake. Antisera to both whole cells and components known to be present on the surface of the cells reduced glucose uptake relative to normal serum. It is suggested that inhibition of glucose uptake may be one mechanism by which a caries vaccine may operate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE serums
KW - CELLS
KW - IMMUNOGLOBULINS
KW - GLUCOSE
KW - STREPTOCOCCUS
KW - DENTAL caries
KW - antibodies
KW - glucose uptake
KW - S. mutans.
N1 - Accession Number: 13232494; Rölla, Gunnar 1,2 Little, Wayne A. 1,2 Ciardi, Joseph E. 1,2; Affiliation: 1: Department of Pedodontics, Dental Faculty, University of Oslo, Oslo, Norway 2: National Caries Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA; Source Info: 1985, Vol. 93 Issue 1, p13; Subject Term: IMMUNE serums; Subject Term: CELLS; Subject Term: IMMUNOGLOBULINS; Subject Term: GLUCOSE; Subject Term: STREPTOCOCCUS; Subject Term: DENTAL caries; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: glucose uptake; Author-Supplied Keyword: S. mutans.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Albrecht, Gary L.
AU - Jackson, David J.
T1 - The Social Context of Policy Research.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1985/02//
VL - 13
IS - 3
M3 - Article
SP - 275
SN - 00491241
AB - Presents an introduction to the February 1985 issue of the periodical "Sociological Methods & Research".
KW - SOCIOLOGICAL research
KW - SOCIOLOGICAL Methods & Research (Periodical)
N1 - Accession Number: 5819275; Albrecht, Gary L. 1 Jackson, David J. 2; Affiliation: 1: University of Illinois, Chicago. 2: National Institute of Mental Health.; Source Info: Feb85, Vol. 13 Issue 3, p275; Subject Term: SOCIOLOGICAL research; Reviews & Products: SOCIOLOGICAL Methods & Research (Periodical); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsujibo, Hiroshi
AU - Tiano, Howard F.
AU - Li, Steven S. -L.
T1 - Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/02/15/
VL - 147
IS - 1
M3 - Article
SP - 9
EP - 15
PB - Wiley-Blackwell
SN - 00142956
AB - Eight cDNA clones for lactate dehydrogenase-A isozyme (LDH-A) were isolated from a human fibroblast cDNA library, characterized, and no sequence heterogeneity was found. Four cDNA clones appear to contain nearly full-length cDNA inserts and the complete nucleotide sequence of 1710 base pairs consists of the protein-coding sequence (999 base pairs), the 5′ (97 base pairs) and 3′ (565 base pairs) untranslated regions and poly(dA) tail (49 base pairs). The predicted amino acid sequence of the human LDH-A polypeptide shows 92% homology (27 differences out of 331 amino acids compared) with that of the pig LDH-A subunit determined by direct protein sequencing [Kiltz et al. (1977) Hoppe-Seyler's Z. Physiol. Chem. 358, 123–127]. Human genomic clones containing an LDH-A pseudogene were isolated and the nucleotide sequence of 1635 base pairs from an intronless pseudogene was determined. The presence of two termination codons, two deletions of three nucleotides each and the replacement of three arginine residues at the active site (nos 98, 105 and 168) by other amino acids renders its coding region incapable of producing a functional LDH-A protein. A comparison between human LDH-A cDNA and the pseudogene sequences reveals 12.9% differences (114 transitions, 65 transversions and 36 deletions/ insertions). Further, only four out of the 25 dCpdG dinucleotides present in the eDNA sequence remain unchanged. although the sequences possess 87.1% homology. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BINDING sites (Biochemistry)
KW - DNA
KW - NUCLEOTIDE sequence
KW - NUCLEIC acids -- Analysis
KW - LACTATE dehydrogenase
KW - PROTEINS -- Analysis
KW - NUCLEOTIDES
KW - ARGININE
KW - DEHYDROGENASES
N1 - Accession Number: 13817680; Tsujibo, Hiroshi 1 Tiano, Howard F. 1 Li, Steven S. -L. 1; Affiliation: 1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; Source Info: 2/15/85, Vol. 147 Issue 1, p9; Subject Term: BINDING sites (Biochemistry); Subject Term: DNA; Subject Term: NUCLEOTIDE sequence; Subject Term: NUCLEIC acids -- Analysis; Subject Term: LACTATE dehydrogenase; Subject Term: PROTEINS -- Analysis; Subject Term: NUCLEOTIDES; Subject Term: ARGININE; Subject Term: DEHYDROGENASES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - King, Haitung
AU - Jun-Yao Li
AU - Locke, Frances B.
AU - Pollack, Earl S.
AU - Ji-Tao Tu
T1 - Patterns of Site-Specific Displacement in Cancer Mortality among Migrants: The Chinese in the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/03//
VL - 75
IS - 3
M3 - Article
SP - 237
PB - American Public Health Association
SN - 00900036
AB - Abstract: Taking advantage of the information gathered for the 1975 National Mortality Survey in China. This paper compares the levels of cancer mortality among foreign-born and United Statesborn Chinese around 1970 with those of the communities of origin of the majority of Chinese migrants to the US. Age-adjusted rated indicate two distinctive site-specific patterns among US Chinese: a downward trend for cancers of high risk among Guangdong and Hong Kong Chinese masopharynx, esophagus, liver, uterus, and perhaps stomach) and an upward trend for those sites of risk among Chinese in Guangdong and Hong Kong (colon, lung, leukemia, and female breast. Further field studies are needed with emphasis on the birthplace of migrants and environmental change in host countries. (Am J Public Health 1985: 75-237-242). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER -- Mortality
KW - CANCER -- Etiology
KW - CANCER -- Environmental aspects
KW - CANCER patients
KW - CHINESE -- United States
KW - UNITED States
KW - GUANGDONG Sheng (China)
KW - HONG Kong Island (China)
KW - CHINA
N1 - Accession Number: 4948552; King, Haitung 1,2,3,4 Jun-Yao Li 1,2,3,4 Locke, Frances B. 1,2,3,4 Pollack, Earl S. 1,2,3,4 Ji-Tao Tu 1,2,3,4; Affiliation: 1: National Cancer Institute. 2: Georgetown University. 3: Chinese Cancer Research Institute. 4: Shanghai Cancer Institute.; Source Info: Mar1985, Vol. 75 Issue 3, p237; Subject Term: CANCER -- Mortality; Subject Term: CANCER -- Etiology; Subject Term: CANCER -- Environmental aspects; Subject Term: CANCER patients; Subject Term: CHINESE -- United States; Subject Term: UNITED States; Subject Term: GUANGDONG Sheng (China); Subject Term: HONG Kong Island (China); Subject Term: CHINA; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawrence, Charles E.
AU - Reilly, Andrew A.
AU - Quickenton, Phillip
AU - Greenwald, Peter
AU - Page, William F.
AU - Kuntz, Amy J.
T1 - Mortality Patterns of New York State Vietnam Veterans.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/03//
VL - 75
IS - 3
M3 - Article
SP - 277
PB - American Public Health Association
SN - 00900036
AB - Abstract: Mortality odds ratios (MORs) comparing veterans with Vietnam service who died in New York State to veterans of the Vietnam era with no Vietnam service were estimated (N - 1.496). The most elevated M()Rs and their confidence intervals were nonmotor vehicular injuries of transport (MOR = 2.18. (l. 19. 3.96}). other accidents and burns MOR = 1.37. 10.95. l.98)), and homicide (MOR = 1.59. (0.86. 2.94). (Am J Public Health 1985; 75:277-279.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY -- Statistics
KW - DEATH -- Causes
KW - ACCIDENTS
KW - DIOXINS
KW - HERBICIDES -- Physiological effect
KW - VIETNAM veterans
KW - VIETNAM War, 1961-1975
KW - PUBLIC health
KW - NEW York (State)
N1 - Accession Number: 4948576; Lawrence, Charles E. 1 Reilly, Andrew A. 1 Quickenton, Phillip 1 Greenwald, Peter 2 Page, William F. 3 Kuntz, Amy J. 3; Affiliation: 1: New York State Department of Health. 2: National Cancer Institute. 3: Veterans Administration.; Source Info: Mar1985, Vol. 75 Issue 3, p277; Subject Term: MORTALITY -- Statistics; Subject Term: DEATH -- Causes; Subject Term: ACCIDENTS; Subject Term: DIOXINS; Subject Term: HERBICIDES -- Physiological effect; Subject Term: VIETNAM veterans; Subject Term: VIETNAM War, 1961-1975; Subject Term: PUBLIC health; Subject Term: NEW York (State); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levinson, Rachel E.
AU - Stoto, Michael A.
T1 - SCIENCE AND POLICY: TIME FOR DIALOGUE.
JO - BioScience
JF - BioScience
Y1 - 1985/03//
VL - 35
IS - 3
M3 - Book Review
SP - 185
EP - 186
SN - 00063568
AB - Reviews the book 'Biomedical Institutions. Biomedical Funding, and Public Policy,' edited by H.H. Fudenberg.
KW - Medical research
KW - Nonfiction
KW - Biomedical Institutions: Biomedical Funding & Public Policy (Book)
N1 - Accession Number: 10101061; Levinson, Rachel E. 1; Stoto, Michael A. 2; Affiliations: 1: National Institutes of Health; 2: Institute, of Medicine, National Academy of Sciences, 2101 Constitution Avenue, Washington, DC 20418; Issue Info: Mar1985, Vol. 35 Issue 3, p185; Subject Term: Medical research; Subject Term: Nonfiction; Reviews & Products: Biomedical Institutions: Biomedical Funding & Public Policy (Book); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 924
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grusky, Oscar
AU - Tierney, Kathleen
AU - Manderscheid, Ronald W.
AU - Grusky, David B.
T1 - Social Bonding and Community Adjustment of Chronically Mentally Ill Adults.
JO - Journal of Health & Social Behavior
JF - Journal of Health & Social Behavior
Y1 - 1985/03//
VL - 26
IS - 1
M3 - Article
SP - 49
EP - 63
SN - 00221465
AB - This study specifies, estimates, and discusses two models of social adjustment and service use among a national sample of chronically mentally ill adults (N = 971) who participated in the NIMH Community Support Program, a federal-state collaborative effort to assist severely mentally disabled adults to function outside institutions. The first model is a simple unidimensional social bonding model. The second, more complex model distinguishes between types of social bonding, social adjustment, and service use. This model fits substantially better than the first model and is consistent with a large body of current research. Community and work bonding showed strong positive relationships with personal and community adjustment, but the corresponding effects of family bonding are nonsignificant. In addition, the three types of social bonding affected service use differently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTALLY ill
KW - SOCIAL adjustment
KW - SOCIAL interaction
KW - COMMUNITY mental health services
KW - MENTAL health services use
KW - FAMILY relations
N1 - Accession Number: 12919589; Grusky, Oscar 1 Tierney, Kathleen 2 Manderscheid, Ronald W. 3 Grusky, David B. 4; Affiliation: 1: University of California, Los Angeles 2: Seismic Safety Commission, State of California 3: National Institute of Mental Health 4: University of Wisconsin, Madison; Source Info: Mar1985, Vol. 26 Issue 1, p49; Subject Term: MENTALLY ill; Subject Term: SOCIAL adjustment; Subject Term: SOCIAL interaction; Subject Term: COMMUNITY mental health services; Subject Term: MENTAL health services use; Subject Term: FAMILY relations; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 15p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carson, Richard E.
AU - Lange, Kenneth
T1 - A Statistical Model for Position Emission Tomography: Comment.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/03//
VL - 80
IS - 389
M3 - Article
SP - 20
SN - 01621459
AB - The article presents comments of the author on the article "A Statistical Model for Positron Emission Tomography," by V. Vardi, I.A. Shepp and L. Kaufman. Positron emission tomography (EM) provides the capability to quantitatively measure the local concentration of a variety of radionuclides in humans and animals. This high-quality data can be used to elucidate subtleties of physiology and biochemistry in normal and diseased states. Accurate interpretation of the data depends upon quantitative image reconstruction methods combined with the techniques of tracer kinetic modeling. The EM algorithm for image reconstruction in positron emission tomography was first presented by Shepp and Vardi. Independently, authors developed EM algorithms for image reconstruction for emission and transmission tomography. The probability of an emission from pixel index being detected along projection line index are assumed to be known exactly and depend upon the physical factors affecting tomographic projection measurements: radioactive decay, projection sampling scheme, detector efficiency and location, spatial resolution, attenuation, scatter, accidental coincidences, positron range and angulation.
KW - ALGORITHMS
KW - PROBABILITY theory
KW - EMISSION tomography
KW - POSITRON emission
KW - DETECTORS
KW - RADIOACTIVE decay
N1 - Accession Number: 4610323; Carson, Richard E. 1; Lange, Kenneth 2; Affiliations: 1: Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20205.; 2: Department of Biomathematics, UCLA, Los Angeles, CA 90024.; Issue Info: Mar1985, Vol. 80 Issue 389, p20; Thesaurus Term: ALGORITHMS; Thesaurus Term: PROBABILITY theory; Subject Term: EMISSION tomography; Subject Term: POSITRON emission; Subject Term: DETECTORS; Subject Term: RADIOACTIVE decay; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Fredrikson, Mats
AU - Danielssons, Tomas
AU - Engel, Bernard T.
AU - Frisk-Holmberg, Marianne
AU - Strom, Gunnar
AU - Sundin, Orjan
T1 - Autonomic Nervous System Function and Essential Hypertension: Individual Response Specificity With and Without Beta-Adrenergic Blockade.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1985/03//
VL - 22
IS - 2
M3 - Article
SP - 167
EP - 174
SN - 00485772
AB - The aim of the present research was to study individual response specificity in 22 male patients having essential hypertension (HT) and to compare these patients with age-matched male normotensive controls (NT). Four stimuli, letter identification, mental arithmetic, cold pressor and isometric exercise, were administered while recordings were made of: systolic and diastolic blood pressures, heart rate, respiration, forearm and hand blood flows, and skin conductance level and fluctuations. After each session urine samples were collected and epinephrine and norepinephrine levels were analyzed. Twelve subjects in the HT group were given beta-adrenergic blocking agents and retested 1 to 21 months (&Xbar; = 12 months) after the first session. Each response was standardized, using NT as the reference group. Intraclass correlations were computed to evaluate whether HT males reacted with a more consistent hierarchy of responses than did NT. Intraclass correlations were significantly higher among the patients than in the control group, regardless of whether the blood pressure response was included or excluded in the computation of the intraclass correlations. Thus, we conclude that male HT patients show more individual response specificity than NT controls. Beta-adrenergic receptor antagonists reduced levels of cardiovascular activity and attenuated reactivity but did not affect amount of specificity. Thus, intraclass correlations provide unique and useful information, since they are not related to blood pressure reactivity or to urinary catecholamine levels, nor affected by beta-adrenergic blockade. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTONOMIC nervous system
KW - ESSENTIAL hypertension
KW - BLOOD pressure
KW - HEART beat
KW - RESPIRATION
KW - GALVANIC skin response
KW - CATECHOLAMINES
KW - Beta-adrenergic blocking
KW - Blood flow
KW - Blood pressure
KW - Catecholamine
KW - Electrodermal activity
KW - Essential hypertension
KW - Heart rate
KW - Individual response specificity
KW - Respiration
KW - Response patterns.
N1 - Accession Number: 11026855; Fredrikson, Mats 1,2 Danielssons, Tomas 2 Engel, Bernard T. 3 Frisk-Holmberg, Marianne 2 Strom, Gunnar 2 Sundin, Orjan 2; Affiliation: 1: Department of Psychiatry and Psychology, Karolinska Institute, Stockholm. Sweden, 2: University Hospital, Uppsala Sweden. 3: Gerontology, Research Center National Institute on Aging Bethesda and Baltimore City Hospital.; Source Info: Mar1985, Vol. 22 Issue 2, p167; Subject Term: AUTONOMIC nervous system; Subject Term: ESSENTIAL hypertension; Subject Term: BLOOD pressure; Subject Term: HEART beat; Subject Term: RESPIRATION; Subject Term: GALVANIC skin response; Subject Term: CATECHOLAMINES; Author-Supplied Keyword: Beta-adrenergic blocking; Author-Supplied Keyword: Blood flow; Author-Supplied Keyword: Blood pressure; Author-Supplied Keyword: Catecholamine; Author-Supplied Keyword: Electrodermal activity; Author-Supplied Keyword: Essential hypertension; Author-Supplied Keyword: Heart rate; Author-Supplied Keyword: Individual response specificity; Author-Supplied Keyword: Respiration; Author-Supplied Keyword: Response patterns.; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-8986.ep11026855
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Ray
AU - Donchin, Emanuel
T1 - Second Thoughts: Multiple P300s Elicited by a Single Stimulus.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1985/03//
VL - 22
IS - 2
M3 - Article
SP - 182
EP - 194
SN - 00485772
AB - In a previous report (Johnson & Donchin, 1978), we manipulated the discriminability of tone pairs that delivered feedback information in a time-estimation paradigm. As in other experiments using feedback stimuli, the event-related potentials elicited by these stimuli did not return to baseline in the 800-ms poststimulus interval. Since we were interested in this "Slow Wave" activity, the poststimulus interval was lengthened to 1500 ms. Averages revealed that a second positive peak was present for some of the individual subjects. To investigate this activity further, the filtered single- trial waveforms were inspected visually. These data were characterized by the presence of one, and occasionally two, positive peaks, with highly variable latencies, following the P300. These peaks were indistinguishable in frequency and general appearance from the P300s elicited by the feedback stimuli, After latency adjusting the waveforms on the peak of the second positive wave, amplitude and latency were quantified. Whereas P300 amplitude was directly related to stimulus discriminability and positive feedback elicited larger P300s than negative feedback, the amplitude of the second positive wave was constant across levels of discriminability and the same for both types of feedback. In contrast, the latencies of both waves were inversely related to stimulus discriminability and shorter following positive feedback than negative feedback. Evidence is presented to support our contention that these additional positive peaks represent P300 activity. The data are discussed in terms of what these multiple P300s reveal about human information processing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVOKED potentials (Electrophysiology)
KW - ELECTROPHYSIOLOGY
KW - FEEDBACK (Psychology)
KW - DECISION making
KW - HUMAN information processing
KW - PERCEPTION
KW - Decision making.
KW - Event-related potentials. P300
KW - Feedback
N1 - Accession Number: 11026877; Johnson, Ray 1 Donchin, Emanuel 2; Affiliation: 1: The National Institutes of Health, NINCDS/Medical Neurology Branch, Bethesda, Maryland. 2: Cognitive Psychophysiology Laboratory, Depart meni of Psychology, University of Illinois, Champaign.; Source Info: Mar1985, Vol. 22 Issue 2, p182; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: ELECTROPHYSIOLOGY; Subject Term: FEEDBACK (Psychology); Subject Term: DECISION making; Subject Term: HUMAN information processing; Subject Term: PERCEPTION; Author-Supplied Keyword: Decision making.; Author-Supplied Keyword: Event-related potentials. P300; Author-Supplied Keyword: Feedback; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1469-8986.ep11026877
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eisenberg, Evan
AU - Hill, Terrell L.
T1 - Muscle Contraction and Free Energy Transduction in Biological Systems.
JO - Science
JF - Science
Y1 - 1985/03//3/ 1/1985
VL - 227
IS - 4690
M3 - Article
SP - 999
EP - 1006
SN - 00368075
N1 - Accession Number: 84692156; Eisenberg, Evan 1 Hill, Terrell L. 2; Affiliation: 1: Head of the Section on Cellular Physiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20205 2: Head of the Section on Theoretical Molecular Biology, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20205; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p999; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SAXINGER, W. CARL
AU - LEVINE, PAUL H.
AU - DEAN, A. G.
AU - THE, GuY DE
AU - LANGE-WANTZIN, GUNHILD
AU - MOGHISSI, JASMINE
AU - LAURENT, FRANCINE
AU - HOH, MEI
AU - SARNGADHARAN, M. G.
AU - GALLO, ROBERT C.
T1 - Evidence for Exposure to HTLV-III in Uganda Before 1973.
JO - Science
JF - Science
Y1 - 1985/03//3/ 1/1985
VL - 227
IS - 4690
M3 - Article
SP - 1036
EP - 1038
SN - 00368075
AB - Fifty of 75 serum samples collected in the West Nile district of Uganda between August 1972 and July 1973 contained antibodies reactive with human T-cell leukemia (lymphotropic) virus type 3 (HTLV-Ill; mean titer, 601), while 12 of 75 samples were positive in a similar test for HTLV type I (HTLV-I) antibodies (mean titer, 236). The samples were screened by enzyme-linked immunosorbent assay and positive results were confirmed by a newly developed unlabeled antibody-peroxidase procedure with enhanced sensitivity for detection of antibody binding to immunoblots of HTLV-II antigen, demonstrating antibodies to proteins with molecular weights of 24,000, 41,000, and 76,000 in nearly all positive samples. Analysis of titration data indicated enhanced titers of antibody against HTLV-III and HTLV-I when coinfection occurred. The high prevalence and relatively low titers [compared to serum from patients with acquired immune deficiency syndrome (AIDS)] of antibodies recognizing HTLV-Ill proteins in sera from this population at a time that may predate or coincide with the appearance or spread of the AIDS agent (HTLVIII) suggest that the virus detected may have been a predecessor of HTLV-IlI or is HTLV-III itself but existing in a population acclimated to its presence. It further suggests an African origin of HTLV-III. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692179; SAXINGER, W. CARL 1 LEVINE, PAUL H. 2 DEAN, A. G. 3 THE, GuY DE 4 LANGE-WANTZIN, GUNHILD 5 MOGHISSI, JASMINE 6 LAURENT, FRANCINE 6 HOH, MEI 6 SARNGADHARAN, M. G. 6 GALLO, ROBERT C. 6; Affiliation: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205 2: Clinical Epidemiology Branch, National Cancer Institute 3: International Agency for Research in Cancer, Lyon, France 4: Laboratoire d'Epide6miologie et Immunovirologie des Tumeurs, Lyon, France 5: Bispebjerg Hospital, Copenhagen, Denmark 6: Laboratory of Tumor Cell Biology, National Cancer Institute; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p1036; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SCHMALJOHN, C. S.
AU - HASTY, S. E.
AU - DALRYMPLE, J. M.
AU - LEDUC, J. W.
AU - LEE, H. W.
AU - BONSDORFF, C.-H. VON
AU - BRUMMER-KORVENKONTIO, M.
AU - VAHERI, A.
AU - TSAI, T. F.
AU - REGNERY, H. L.
AU - GOLDGABER, D.
AU - LEE, P. W.
T1 - Antigenic and Genetic Properties of Viruses Linked to Hemorrhagic Fever with Renal Syndrome.
JO - Science
JF - Science
Y1 - 1985/03//3/ 1/1985
VL - 227
IS - 4690
M3 - Article
SP - 1041
EP - 1044
SN - 00368075
AB - Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692181; SCHMALJOHN, C. S. 1 HASTY, S. E. 1 DALRYMPLE, J. M. 1 LEDUC, J. W. 1 LEE, H. W. 2 BONSDORFF, C.-H. VON 3 BRUMMER-KORVENKONTIO, M. 3 VAHERI, A. 3 TSAI, T. F. 4 REGNERY, H. L. 4 GOLDGABER, D. 5 LEE, P. W. 5; Affiliation: 1: Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701 2: Institute for Viral Diseases, Korea University College of Medicine, Seoul, Korea 3: Department of Virology, University of Helsinki, Helsinki, Finland 4: Viral Diseases Division, Centers for Disease Control, Atlanta, Georgia 30333 5: Laboratory of Central Nervous Studies, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20205; Source Info: 3/ 1/1985, Vol. 227 Issue 4690, p1041; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krauze, Tadeusz
AU - Slomczynski, Kazimierz M.
T1 - How Far to Meritocracy? Empirical Tests of a Controversial Thesis.
JO - Social Forces
JF - Social Forces
Y1 - 1985/03//
VL - 63
IS - 3
M3 - Article
SP - 623
EP - 642
PB - Oxford University Press / USA
SN - 00377732
AB - Abstract The meritocratic thesis states that a strong association between individual "merit" and social rewards is inherent in highly industrialized society. A simple model of meritocratic allocation is proposed and applied to provide empirical assessment of "how far to meritocracy?" from empirical reality. The model, conceptualized as an ideal type of meritocracy, incorporates the principle according to which more educated persons do not have lower status than less educated ones. Assuming that a meritocratic society should resemble its ideal type, we have formulated three testable hypotheses involving status mobility within educational groups, status determination by education, and status inequality among educational groups. The tests consist of evaluating the discrepancies between the data on the U.S. total labor force and the model. All three hypotheses implying that American society is close to meritocracy are rejected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TECHNOCRACY
KW - EDUCATION
KW - SOCIAL status
KW - EQUALITY
KW - LABOR supply
KW - UNITED States
N1 - Accession Number: 5281777; Krauze, Tadeusz 1 Slomczynski, Kazimierz M. 2,3; Affiliation: 1: Hofstra University 2: University of Warsaw 3: National Institute of Mental Health; Source Info: Mar85, Vol. 63 Issue 3, p623; Subject Term: TECHNOCRACY; Subject Term: EDUCATION; Subject Term: SOCIAL status; Subject Term: EQUALITY; Subject Term: LABOR supply; Subject Term: UNITED States; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06422-032
AN - 2006-06422-032
AU - Wolfe, Barry E.
T1 - The Temporary Accommodation of Eclecticism.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1985/03//
VL - 30
IS - 3
SP - 223
EP - 224
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06422-032. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wolfe, Barry E.; Psychosocial Treatments Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Counseling; Eclectic Psychotherapy; Therapeutic Processes. Minor Descriptor: Therapists. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Hart, Joseph. Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists=New York: Plenum Press, 1983. 404 pp. $37.50; 1983. References Available: Y. Page Count: 2. Issue Publication Date: Mar, 1985.
AB - Reviews the book, Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists by Joseph Hart (1983). Tha author's book presents what he believes to be a comprehensive theoretical framework applicable to most therapists and all patients. The most useful section of the book is the manual that the author developed for his therapy. As a statement of one man's therapeutic eclecticism, this book is a useful and interesting document. The author has gone to some pains to systematize his programmatic, action-oriented therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - eclectic therapy
KW - functional orientation
KW - counseling
KW - psychotherapy
KW - therapeutic eclecticism
KW - 1985
KW - Counseling
KW - Eclectic Psychotherapy
KW - Therapeutic Processes
KW - Therapists
KW - 1985
U2 - Hart, Joseph. (1983); Modern Eclectic Therapy: A Functional Orientation to Counseling and Psychotherapy. Including a Twelve-Month Manual for Therapists; New York: Plenum Press, 1983. 404 pp. $37.50
DO - 10.1037/023648
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Krohn, K.
AU - Ranki, Annamarj
AU - Antonen, J.
AU - Valle, Sirka-Lijsa
AU - Suni, J.
AU - Saxinger, C.
AU - Gallo, R. C.
T1 - Immune functions in homosexual men with antibodies to HTLV-III in Finland.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1985/04//
VL - 60
IS - 1
M3 - Article
SP - 17
EP - 24
PB - Wiley-Blackwell
SN - 00099104
AB - The occurrence of HTLV-III anbbodies in a voluntary group of 175 homosexual men in a low risk AIDS area was studied, and the findings were correlated to clinical, virological immunological and lifestyle parameters Fifteen of 175 men had HTLV-III antibodies: two of these had AIDS, five had LAS and two had enlarged lymph nodes. In the HTLV-III antibody negative group, no signs of AIDS or pre-AIDS were seen during a 10 month follow-up. In HTLV-III antibody positive individuals, low THTS ratio was mainly due to decreased number of TS cogs Most HTLV-III antibody positive cases had low responses In a specific antigen. PPD while responses to the mitogens PHA and PWM were only slightly affected. In HTLV-III antibody negative cases, 13% had a low TH/TS ratio, mostly due to elevation of Ts cells. In this group, mitogen and antigen responses were normal or only slightly affected. The results reinforce the causal relationship between HTLV-III and AIDS and suggest that the cells primarily affected by the virus infection are TH cells, responsible tot antigen specific responses Longitudinal studies are required to find out, what is the relationship of immune response to the development of clinical AIDS in HTLV-III infected individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - GAY people
KW - IMMUNOGLOBULINS
KW - HIV (Viruses)
KW - LYMPH nodes
KW - IMMUNOLOGY
KW - LYMPHATICS
KW - AIDS
KW - helper T cells
KW - HTLV-III infection
KW - suppressor T cells
N1 - Accession Number: 15961196; Krohn, K. 1 Ranki, Annamarj 2 Antonen, J. 1 Valle, Sirka-Lijsa 2 Suni, J. 3,4 Saxinger, C. 5 Gallo, R. C. 5; Affiliation: 1: Institute of Biomedical Sciences, University of Tampere, Tampere. 2: Department of Dermatology and Venerology, Helsinki University Central Hospital. 3: Department of Virology, Helsinki University. 4: Aurora Microbiological Laboratory, Helsinki, Finland. 5: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, USA.; Source Info: Apr1985, Vol. 60 Issue 1, p17; Subject Term: IMMUNE response; Subject Term: GAY people; Subject Term: IMMUNOGLOBULINS; Subject Term: HIV (Viruses); Subject Term: LYMPH nodes; Subject Term: IMMUNOLOGY; Subject Term: LYMPHATICS; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: helper T cells; Author-Supplied Keyword: HTLV-III infection; Author-Supplied Keyword: suppressor T cells; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Handwerger, B. S.
AU - Fernandes, G.
AU - Riehm, Terri
AU - Yoon, J.-W.
AU - Sutherland, D. E. R.
AU - Brown, D. M.
T1 - Alterations in immunological reactivity in encephalomyocarditis virus-induced murine diabetes. I. Defective primary IgM plaque forming cell responses to sheep erythrocytes: correction by islet cell transplantation.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1985/04//
VL - 60
IS - 1
M3 - Article
SP - 145
EP - 150
PB - Wiley-Blackwell
SN - 00099104
AB - Increasing data suggest a possible viral aetiology of juvenile onset, insulin-dependent diabetes mellitus. The M variant of the encephalomyocarditis (EMC) virus infects murine pancreatic beta cells and causes a diabetes like syndrome in susceptible strains of mice. Abnormalities in immunological function have been documented in patients with diabetes mellitus and in spontaneous. streptozotocin-induced and alloxan-induced diabetes in animals. The present study documents a significant impairment of the ability of mice with EMC virus (M variant)-induced diabetes to generate a direct. IgM PFC response after in vivo immunization with sheep erythrocytes. This abnormality appears to be a direct consequence of the diabetic state and not EMC virus infection, per se, since (1) mice infected with EMC virus that do not become diabetic have normal direct PEC responses and (2) islet cell transplantation, which cures the diabetes. corrects the defect in PFC responsiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - IMMUNOGLOBULIN M
KW - CELLS
KW - ERYTHROCYTES
KW - CARBOHYDRATE intolerance
KW - PANCREATIC beta cells
KW - IMMUNIZATION
KW - diabetes
KW - EMC virus
KW - immunity
N1 - Accession Number: 15961599; Handwerger, B. S. 1,2,3 Fernandes, G. 4 Riehm, Terri 2 Yoon, J.-W. 5 Sutherland, D. E. R. 5 Brown, D. M. 3; Affiliation: 1: Rheumatology Research Unit and Departments of Medicine and Immunology, Mayo Clinic/Foundation, Rochester, Minnesota. 2: Research and Medical Services, Veterans Administration Center, Minneapolis. 3: Departments of Medicine and Microbiology, Surgery, Pediatrics and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis. 4: Division of Clinical Immunology and Arthritis, Department of Medicine, University of Texas, San Antonio, Texas. 5: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1985, Vol. 60 Issue 1, p145; Subject Term: DIABETES; Subject Term: IMMUNOGLOBULIN M; Subject Term: CELLS; Subject Term: ERYTHROCYTES; Subject Term: CARBOHYDRATE intolerance; Subject Term: PANCREATIC beta cells; Subject Term: IMMUNIZATION; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: EMC virus; Author-Supplied Keyword: immunity; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zick, Yehiel
AU - Grunberger, George
AU - Rees-Jones, Robert W.
AU - Comi, Richard J.
T1 - 182Use of tyrosine-containing polymers to characterize the substrate specificity of insulin and other hormone-stimulated tyrosine kinases.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/04//4/1/85
VL - 148
IS - 1
M3 - Article
SP - 177
EP - 182
PB - Wiley-Blackwell
SN - 00142956
AB - Synthetic copolymers containing tyrosine residues were used to characterize the substrate specificity of the insulin receptor kinase and compare it to tyrosine kinases stimulated by epidermal growth factor, insulin-like growth factor-1 and phorbol ester. In partially purified receptor preparations from eight different tissues insulin best stimulated (highest V) phosphorylation of a random copolymer composed of glutamic and tyrosine residues at a 4:1 ratio (Glu/Tyr; 4:1). The insulin-stimulated phosphorylation of this polymer was highly significant also in receptor preparations from fresh human monocytes, where insulin binding and autophosphorylation were difficult to detect. Other tyrosine-containing polymers Ala/Glu/Lys/Tyr (6:2:5:1) and Glu/Ala/Tyr (6:3:1) were also phosphorylated by the insulin-stimulated kinase but to a lower extent. A tyrosine kinase stimulated by insulin-like growth factor-1, and one stimulated by phorbol ester also best phosphorylated the polymer Glu/Tyr (4:1). The three kinases differed only in their capability to phosphorylate Glu/Ala/Tyr (6:3:1) or Ala/Glu/Lys/Tyr (6:2:5:1). Glu/Tyr (4:1) was a poor substrate for the epidermal growth factor receptor kinase which best phosphorylated the polymer Glu/Ala/Tyr (6:3:1). Three additional polymers: Glu/Tyr (1:1), Glu/Ala/Tyr (1:1:1), and Lys/Tyr (1:1) failed to serve as substrates for all four tyrosine kinases tested. Taken together these findings suggest that. (a) Hormone-sensitive tyrosine kinases have similar yet distinct substrate specificity and are likely to phosphorylate their native substrates on tyrosines adjacent to acidic (glutamic) residues. (b) Tyrosine-containing polymer substrates are highly sensitive and convenient tools to study (hormone-sensitive) tyrosine kinases whose native substrates are unknown or present at low concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN-tyrosine kinase
KW - EPIDERMAL growth factor
KW - POLYMERS
KW - HORMONES
KW - PHOSPHORYLATION
KW - GLUTAMIC acid
N1 - Accession Number: 13854349; Zick, Yehiel 1 Grunberger, George 2 Rees-Jones, Robert W. 2 Comi, Richard J. 2; Affiliation: 1: Department of Chemical Immunology, Weizmann Institute of Science, P.O. Box 26, IL-76-100 Rehovot, Israel 2: Diabetes Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, USA 20205; Source Info: 4/1/85, Vol. 148 Issue 1, p177; Subject Term: PROTEIN-tyrosine kinase; Subject Term: EPIDERMAL growth factor; Subject Term: POLYMERS; Subject Term: HORMONES; Subject Term: PHOSPHORYLATION; Subject Term: GLUTAMIC acid; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rolla, Gunnar
AU - Aamdal#Scheje, Anne
AU - Ciardi, Joseph E.
T1 - Role of sucrose in plaque formation.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1985/04//
VL - 93
IS - 2
M3 - Article
SP - 105
EP - 111
SN - 0029845X
AB - Results arc presented which support the concept that the bacterial enzyme glucosyltransferase (GTF) plays a crucial role in sucrose induced plaque formation. GTF was shown to adhere strongly to anionic, hydrophobic and polysaccharide solid materials, and to be able to produce glucans in the adsorbed state. It appears conceivable that GTF adsorb to teeth and produce glucans. Glucan chains on the surface of the bacteria and glucans on the tooth surfaces interact (pack) and form a strong binding mechanism. The rigid α1,3 linked glucans produced by Streptococcus mutans are particularly suited for interaction of this kind. This mechanism could account for sucrose-induced binding of bacteria to enamel, pellicle covered enamel and preformed plaque. S. mutans would adhere particularly strongly to tooth surfaces in the presence of sucrose, according to this model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUCROSE
KW - DENTAL plaque
KW - GLYCOSYLTRANSFERASES
KW - POLYSACCHARIDES
KW - GLUCANS
KW - DENTAL enamel
KW - dental caries
KW - dental plaque
KW - glucosyl transfcrase.
KW - sucrose
N1 - Accession Number: 13234608; Rolla, Gunnar 1 Aamdal#Scheje, Anne 2 Ciardi, Joseph E. 2; Affiliation: 1: Dental Faculty, University of Oslo, Norway. 2: National Institute of Dental Research, National Institutes of Health, Bethesda. Maryland, USA.; Source Info: 1985, Vol. 93 Issue 2, p105; Subject Term: SUCROSE; Subject Term: DENTAL plaque; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: POLYSACCHARIDES; Subject Term: GLUCANS; Subject Term: DENTAL enamel; Author-Supplied Keyword: dental caries; Author-Supplied Keyword: dental plaque; Author-Supplied Keyword: glucosyl transfcrase.; Author-Supplied Keyword: sucrose; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2013-42007-010
AN - 2013-42007-010
AU - Susman, Elizabeth J.
AU - Trickett, Penelope K.
AU - Iannotti, Ronald J.
AU - Hollenbeck, Barbara E.
AU - Zahn-Waxler, Carolyn
T1 - Child-rearing patterns in depressed, abusive, and normal mothers.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1985/04//
VL - 55
IS - 2
SP - 237
EP - 251
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Zahn-Waxler, Carolyn, Laboratory of Developmental Psychology, National Institute of Mental Health, Bldg. 1 5K . 9000 Rockville Pike, Bethesda, MD, US, 20205
N1 - Accession Number: 2013-42007-010. PMID: 3993753 Partial author list: First Author & Affiliation: Susman, Elizabeth J.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aspiration Level; Childrearing Practices; Emotional Control; Mothers; Separation Individuation. Classification: Behavior Disorders & Antisocial Behavior (3230); Childrearing & Child Care (2956). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Schedule for Affective Disorders and Schizophrenia-Lifetime; Block Q-sort Instrument; Child-Rearing Practices Report DOI: 10.1037/t00815-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Apr, 1985. Copyright Statement: American Orthopsychiatric Association, Inc. 1985.
AB - Child-rearing patterns in relation to discipline, emotion regulation, separation-individuation, and level of aspiration differentiated depressed, abusive, and normal mothers. Depressed and abusive mothers both expressed inconsistency, hostility, and protectiveness. Both groups used anxiety and guilt inducing methods but only abusive mothers used them in conjunction with harsh authoritarian practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child-rearing patterns
KW - abusive mothers
KW - emotion regulation
KW - guilt inducing methods
KW - 1985
KW - Aspiration Level
KW - Childrearing Practices
KW - Emotional Control
KW - Mothers
KW - Separation Individuation
KW - 1985
DO - 10.1111/j.1939-0025.1985.tb03438.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - DEFEO-JONES, DEBORAH
AU - TATCHELL, KELLY
AU - ROBINSON, Lucy C.
AU - SIGAL, IRVING.S.
AU - VASS, WILLIAM C.
AU - LOWY, DOUGLAS R.
AU - SCOLNICK, EDWARD M.
T1 - Mammalian and Yeast ras Gene Products: Biological Function in Their Heterologous Systems.
JO - Science
JF - Science
Y1 - 1985/04/12/
VL - 228
IS - 4696
M3 - Article
SP - 179
EP - 184
SN - 00368075
AB - Activated versions of ras genes have been found in various types of malignant tumors. The normal versions of these genes are found in organisms as diverse as mammals and yeasts. Yeast cells that lack their functional ras genes, RASsc-J and RASsc-2, are ordinarily nonviable. They have now been shown to remain viable if they carry a mammalian rasH gene. In addition, yeast-mammalian hybrid genes and a deletion mutant yeast RASsc-J gene were shown to induce morphologic transformation of mouse NIH 3T3 cells when the genes had a point mutation analogous to one that increases the transforming activity of mammalian ras genes. The results establish the functional relevance of the yeast system to the genetics and biochemistry of cellular transformation induced by mammalian ras genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692224; DEFEO-JONES, DEBORAH 1 TATCHELL, KELLY 2 ROBINSON, Lucy C. 2 SIGAL, IRVING.S. 3 VASS, WILLIAM C. 4 LOWY, DOUGLAS R. 4 SCOLNICK, EDWARD M. 3; Affiliation: 1: Department of Virus and Cell Biology, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486 2: Department of Biology, G5, University of Pennsylvania, Philadelphia 19104 3: Department of Virus and Cell Biology, Merck Sharp & Dohme Research Laboratories 4: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 4/12/1985, Vol. 228 Issue 4696, p179; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sandler, Dale P.
AU - Everson, Richard B.
AU - Wilcox, Allen J.
AU - Browder, James P.
T1 - Cancer Risk in Adulthood from Early Life Exposure to Parents' Smoking.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/05//
VL - 75
IS - 5
M3 - Article
SP - 487
EP - 492
PB - American Public Health Association
SN - 00900036
AB - We obtained data on smoking by parents from 438 cancer cases nd 470 controls to investigate whether cancer risk in adult life is related to transplacental or childhood exposure to cigarette smoke. Cancer cases were between ages 15 and 59 at time of diagnosis. All 'sites but basal cell cancer of the skin were included. Cancer risk was increased 50 per cent among offspring of men who smoked, increased risk associated with father's smoking was not explained by demographic factors social class, or individual smoking habits and was not limited to known smoking related sites. Relative risk (RR) estimates associated with father's smoking tended to be greatest for smokers, males, and non-Whites. There was only a slight increase in overall cancer risk associated with maternal smoking. Mother's and father's smoking were both associated with risk for hematopoietic cancers, and a dose-response relationship was seen. The RR for hematopoietic cancers increased flora 1.7 when one parent smoked to 4.6 when both parents smoked. Although they should be considered tentative study findings suggest a long-term hazard from transplacental or childhood passive exposure to cigarette smoke. (Am J Public Health 1985: 75:487-492.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER patients
KW - CIGARETTE smokers
KW - DISEASES
KW - OLDER people
KW - PARENTS
KW - SMOKING
KW - SYMPTOMS
KW - HEMATOPOIETIC system
KW - HEMATOPOIESIS
N1 - Accession Number: 4949286; Sandler, Dale P. 1 Everson, Richard B. 2 Wilcox, Allen J. 2 Browder, James P. 3; Affiliation: 1: Epidemiology Branch, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Mail Drop A3-02. P.O. Box 12233, Research Triangle Park, NC 27709. 2: National Institute of Environmental Health Sciences. 3: Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill.; Source Info: May85, Vol. 75 Issue 5, p487; Subject Term: CANCER patients; Subject Term: CIGARETTE smokers; Subject Term: DISEASES; Subject Term: OLDER people; Subject Term: PARENTS; Subject Term: SMOKING; Subject Term: SYMPTOMS; Subject Term: HEMATOPOIETIC system; Subject Term: HEMATOPOIESIS; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eto, Hikaru
AU - Hashimoto, Ken
AU - Kobayashi, Hitoshi
AU - Matsumoto, Mitsuhiro
AU - Kanzaki, Tamotsu
AU - Mehregan, Amir H.
AU - Weiss, Robert A.
T1 - Monoclonal Antikeratin Antibody: Production, Characterization, and Immunohistochemical Application.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/05//
VL - 84
IS - 5
M3 - Article
SP - 404
EP - 409
SN - 0022202X
AB - A monoclonal antikeratin antibody, EKH4, was produced from a hybridoma cell line which was established by fusing P3X63SAg8 mouse myeloma cells with spleen cells of mice immunized with human trichilemmoma cells. Immunoblot analysis showed that EKH4 antibody reacts predominantly with 50 kilodalton keratin polypeptide in normal epidermis. By indirect immunofluorescence and immunoperoxidase techniques, EKH4 antibody reacted with the lower 2-3 cell layers of the epidermis as well as most cells of pilosebaceous follicle of human and animal skin. Tumor cells of human basal cell epitheliomas and squamous cell carcinomas were also stained with this antibody. The staining was much more regular and intense compared with an available monoclonal antikeratin antibody, AE1. In the lesion of epidermal proliferative disorders, such as psoriasis and actinic keratosis, the entire epidermis instead of the lower layers was stained with EKH4 antibody. Normal skin overlying or adjacent to epithelial tumors also showed positive staining in the entire epidermis. By using indirect immunoperoxidase technique, EKH4 also stained alcohol-fixed, paraffin-embedded tissue sections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - CELL lines
KW - SPLEEN
KW - MICE as laboratory animals
KW - IMMUNOFLUORESCENCE
KW - SQUAMOUS cell carcinoma
KW - BASAL cell carcinoma
KW - PSORIASIS
N1 - Accession Number: 12265506; Eto, Hikaru 1,2 Hashimoto, Ken 1,2 Kobayashi, Hitoshi 1,2 Matsumoto, Mitsuhiro 1,2 Kanzaki, Tamotsu 1,2 Mehregan, Amir H. 1,2 Weiss, Robert A. 3; Affiliation: 1: Department of Dermatology and Syphilology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A. 2: Research Service, Veterans Administration Medical Center, Allen Park, Michigan, U.S.A. 3: Dermatology Branch of the National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May85, Vol. 84 Issue 5, p404; Subject Term: MONOCLONAL antibodies; Subject Term: CELL lines; Subject Term: SPLEEN; Subject Term: MICE as laboratory animals; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SQUAMOUS cell carcinoma; Subject Term: BASAL cell carcinoma; Subject Term: PSORIASIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12265506
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TAYLOR, PHILIP A.
AU - GARRICK, NANCY A.
AU - TAMARKIN, LAWRENCE
AU - MURPHY, DENNIS L.
AU - MARKEY, SANFORD P.
T1 - Diurnal Rhythms of N-Acetylserotonin and Serotonin in Cerebrospinal Fluid of Monkeys.
JO - Science
JF - Science
Y1 - 1985/05/17/
VL - 228
IS - 4701
M3 - Article
SP - 900
EP - 900
SN - 00368075
N1 - Accession Number: 84692299; TAYLOR, PHILIP A. 1 GARRICK, NANCY A. 2 TAMARKIN, LAWRENCE 2 MURPHY, DENNIS L. 2 MARKEY, SANFORD P. 2; Affiliation: 1: MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh EH3 9EW, Scotland 2: National Institute of Mental Health, Bethesda, Maryland 20205; Source Info: 5/17/1985, Vol. 228 Issue 4701, p900; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, James F.
AU - Hockmeyer, Wayne T.
AU - Gross, Mitchell
AU - Ballou, W. Ripley
AU - Wirtz, Robert A.
AU - Trosper, James H.
AU - Beaudoin, Richard L.
AU - Hollingdale, Michael R.
AU - Miller, Louis H.
AU - Diggs, Carter L.
AU - Rosenberg, Martin
T1 - Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine.
JO - Science
JF - Science
Y1 - 1985/05/24/
VL - 228
IS - 4702
M3 - Article
SP - 958
EP - 962
SN - 00368075
AB - The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequencefound in the, CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692309; Young, James F. 1 Hockmeyer, Wayne T. 2 Gross, Mitchell 1 Ballou, W. Ripley 2 Wirtz, Robert A. 3 Trosper, James H. 4 Beaudoin, Richard L. 4 Hollingdale, Michael R. 5 Miller, Louis H. 6 Diggs, Carter L. 2 Rosenberg, Martin 1; Affiliation: 1: Department of Molecular Genetics, Smith Kline and French Laboratories, Philadelphia, Pennsylvania 19101 2: Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307 3: Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20307 4: Malaria Branch, Infectious Diseases Program Center, Naval Medical Research Institute, Bethesda, Maryland 20014 5: Biomedical Research Institute, Rockville, Maryland 20852 6: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205; Source Info: 5/24/1985, Vol. 228 Issue 4702, p958; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BALLOU, W. RIPLEY
AU - ROTHDARD, JONATHAN
AU - WIRTZ, ROBERT A.
AU - GORDON, DANIEL M.
AU - WILLIAMS, JOSEPH S.
AU - GORE, RUFUS W.
AU - SCHNEIDER, IMOGENE
AU - HOLLINGDALE, MICHAEL R.
AU - BEAUDOIN, RICHARD L.
AU - MALOY, W. LEE
AU - HOCKMEYER, WAYNE T.
T1 - Immunogenicity of Synthetic Peptides from Circumsporozoite Protein of Plasmodium falciparum.
JO - Science
JF - Science
Y1 - 1985/05/24/
VL - 228
IS - 4702
M3 - Article
SP - 996
EP - 999
SN - 00368075
AB - In a study of recombinant proteins that might be useful in developing a vaccine against malaria, synthetic peptides from the circumsporozoite (CS) protein of Plasmodium falciparum were found to be immunogenic for mice and rabbits. Antibody to peptides from the repeating region of the CS protein recognized native CS protein and blocked sporozoite invasion of human hepatoma cells in vitro. Antibodies to peptides from regions I and II had no biologic activity, although antibody to region I recognized processed CS protein by Western blot analysis. These data support the feasibility of developing a vaccine against the sporozoite stage of the malaria parasite by using synthetic peptides of the repeating region of the CS protein conjugated to a carrier protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692329; BALLOU, W. RIPLEY 1 ROTHDARD, JONATHAN 2 WIRTZ, ROBERT A. 3 GORDON, DANIEL M. 4 WILLIAMS, JOSEPH S. 4 GORE, RUFUS W. 4 SCHNEIDER, IMOGENE 3 HOLLINGDALE, MICHAEL R. 5 BEAUDOIN, RICHARD L. 6 MALOY, W. LEE 7 HOCKMEYER, WAYNE T. 4; Affiliation: 1: Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307 2: Department of Microbiology, Staford University Medical School, Palo Alto, California 94305 3: Department of Entomology, Walter Reed Army Institute of Research 4: Department of Immunology, Walter Reed Army Institute of Research 5: Biomedical Research Institute, Rockville Maryland 20852 6: Malaria Branch, Infectious Disease Program Center, Naval Medical Research Institute, Bethesda Maryland 20014 7: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases; Source Info: 5/24/1985, Vol. 228 Issue 4702, p996; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collings, Bruce J.
AU - Margolin, Barry H.
T1 - Testing Goodness of Fit for the Poisson Assumption When Observations Are Not Identically Distributed.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/06//
VL - 80
IS - 390
M3 - Article
SP - 411
SN - 01621459
AB - Tests for detecting negative binomial departures from a Poisson model are studied for the one-way-layout and regression-through-the-origin cases. Approximations to the null and alternative distributions of these test statistics are presented. Locally optimal tests and tests suggested in the literature are compared in terms of asymptotic relative efficiency. Small sample comparisons are included. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL optimization
KW - REGRESSION analysis
KW - APPROXIMATION theory
KW - STATISTICS
KW - BINOMIAL distribution
KW - NEGATIVE binomial distribution
KW - POISSON distribution
KW - POISSON processes
KW - ASYMPTOTIC efficiencies (Statistics)
KW - Binomial
KW - Locally optimal tests
KW - Negative binomial
KW - One-way layout
KW - Poisson
KW - Regression through the origin.
N1 - Accession Number: 4614463; Collings, Bruce J. 1; Margolin, Barry H. 2; Affiliations: 1: Assistant Professor of Statistics, Department of Mathematical Sciences, Montana State University, Bozeman, MT 59717.; 2: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Jun85, Vol. 80 Issue 390, p411; Thesaurus Term: MATHEMATICAL optimization; Thesaurus Term: REGRESSION analysis; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: NEGATIVE binomial distribution; Subject Term: POISSON distribution; Subject Term: POISSON processes; Subject Term: ASYMPTOTIC efficiencies (Statistics); Author-Supplied Keyword: Binomial; Author-Supplied Keyword: Locally optimal tests; Author-Supplied Keyword: Negative binomial; Author-Supplied Keyword: One-way layout; Author-Supplied Keyword: Poisson; Author-Supplied Keyword: Regression through the origin.; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Parke, Robert
T1 - State and Metropolitan Area Data (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/06//
VL - 80
IS - 390
M3 - Book Review
SP - 480
SN - 01621459
AB - Reviews the book "State and Metropolitan Area Data: 1982."
KW - STATISTICS
KW - UNITED States
KW - NONFICTION
KW - STATE & Metropolitan Area Data Book: 1982 (Book)
N1 - Accession Number: 4614637; Parke, Robert 1; Affiliations: 1: National Cancer Institute; Issue Info: Jun85, Vol. 80 Issue 390, p480; Thesaurus Term: STATISTICS; Subject Term: UNITED States; Subject Term: NONFICTION; Reviews & Products: STATE & Metropolitan Area Data Book: 1982 (Book); Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Miller, Karen A.
AU - Kohn, Melvin L.
AU - Schooler, Carmi
T1 - Education Self-Direction and the Cognitive Functioning of Students.
JO - Social Forces
JF - Social Forces
Y1 - 1985/06//
VL - 63
IS - 4
M3 - Article
SP - 923
EP - 944
PB - Oxford University Press / USA
SN - 00377732
AB - Abstract This paper reports an analysis of data from a small but substantially representative nationwide sample of white students in seventh grade through college. We propose and measure a concept, educational self-direction, by which we mean the use of initiative, thought, and independent judgment in schoolwork. Reciprocal-effects causal models show that the degree of educational self-direction exercised by students, in particular the substantive complexity of their schoolwork, has a decided impact on their cognitive functioning. Cognitive functioning, in turn, affects the exercise of educational self-direction. Separate models for secondary-school and college students confirm these findings at both educational levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTONOMY (Psychology)
KW - DEPENDENCY (Psychology)
KW - COGNITIVE ability
KW - ABILITY
KW - STUDENTS
KW - SOCIAL psychology
N1 - Accession Number: 5283466; Miller, Karen A. 1,2 Kohn, Melvin L. 1 Schooler, Carmi 1; Affiliation: 1: National Institute of Mental Health. 2: Arizona State University.; Source Info: Jun85, Vol. 63 Issue 4, p923; Subject Term: AUTONOMY (Psychology); Subject Term: DEPENDENCY (Psychology); Subject Term: COGNITIVE ability; Subject Term: ABILITY; Subject Term: STUDENTS; Subject Term: SOCIAL psychology; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-12271-025
AN - 2007-12271-025
AU - Ragland, Sherman L.
T1 - Current issues regarding citizen participation in mental health services for minority groups.
T3 - Psychotherapy with Ethnic Minorities
JF - Psychotherapy: Theory, Research, Practice, Training
JO - Psychotherapy: Theory, Research, Practice, Training
JA - Psychotherapy (Chic)
Y1 - 1985///Sum 1985
VL - 22
IS - 2S
SP - 477
EP - 478
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
SN - 1939-1536
N1 - Accession Number: 2007-12271-025. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research & Practice. Partial author list: First Author & Affiliation: Ragland, Sherman L.; National Institute of Mental Health, US. Other Publishers: Educational Publishing Foundation. Release Date: 20070813. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Involvement; Community Mental Health Centers; Health Care Delivery; Mental Health Services; Minority Groups. Minor Descriptor: Volunteers. Classification: Community & Social Services (3373). Population: Animal (20). Location: US. References Available: Y. Page Count: 2. Issue Publication Date: Sum 1985. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1985.
AB - Volunteer citizen participation has long been recognized as a basic feature of the American character. Community involvement has long been the major strength of the Community Mental Health Program and was intended primarily to assure responsiveness. In addition to responsiveness it also assures accountability. One of the most effective ways to ensure that minorities are receiving adequate mental health services is to have them represented on boards of agencies that deliver those services. The community mental health center (CMHC) must be familiar with the social and political structure of the community, develop mutual trust between the professional and community spokesperson, and guarantee the cooperation of community leaders. The board of the CMHC must develop networks of community service. Board participation bridges the gap between the professional and the community. This is valuable for the mental health professionals who want input into the community, its leadership, institutions, and behavioral patterns. It is also important for the clients and residents in the community to have influence on the type and amount of services available to them. In much the same way, giving mental health clients some control and responsibility over their own treatment processes has been shown to be effective. It is the author's opinion that the issues that have been raised the past 10 years in regard to mental health service delivery to minorities is still relevant. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - volunteer citizen participation
KW - mental health services
KW - minority groups
KW - community mental health centers
KW - service delivery
KW - 1985
KW - Community Involvement
KW - Community Mental Health Centers
KW - Health Care Delivery
KW - Mental Health Services
KW - Minority Groups
KW - Volunteers
KW - 1985
DO - 10.1037/h0085533
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Li, Steven S. -L.
AU - Tiano, Howard F.
AU - Fukasawa, Kayoko M.
AU - Yagi, Kiyohito
AU - Shimizu, Motoyuki
AU - Sharief, Farida S.
AU - Nakashima, Yasutsugu
AU - Pan, Yu-ching E.
T1 - Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/06/03/
VL - 149
IS - 2
M3 - Article
SP - 215
EP - 225
PB - Wiley-Blackwell
SN - 00142956
AB - The complete covalent structure of the 331 amino acids of mouse lactate dehydrogenase (LDH) A4 isozyme has been determined by sequence analyses of both the protein and the genomic DNA. The mouse LDH-A gene spans a length of at least 7000 bases from the translation initiation codon ATG to the end of the 3′ untranslated region, and it contains six introns that interrupt the pro era-coding sequence. The relationships between the exon-intron organization of LDH-A gene and the structural-functional domains of the protein are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - AMINO acid sequence
KW - GENES
KW - LACTATE dehydrogenase
KW - ISOENZYMES
KW - EXONS (Genetics)
KW - INTRONS
KW - MICE as laboratory animals
N1 - Accession Number: 13841117; Li, Steven S. -L. 1 Tiano, Howard F. 1 Fukasawa, Kayoko M. 1 Yagi, Kiyohito 1 Shimizu, Motoyuki 1 Sharief, Farida S. 1 Nakashima, Yasutsugu 1 Pan, Yu-ching E. 1; Affiliation: 1: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina; Source Info: 6/3/85, Vol. 149 Issue 2, p215; Subject Term: PROTEINS; Subject Term: AMINO acid sequence; Subject Term: GENES; Subject Term: LACTATE dehydrogenase; Subject Term: ISOENZYMES; Subject Term: EXONS (Genetics); Subject Term: INTRONS; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Symmes, D.
AU - Biben, M.
T1 - Maternal Recognition of Individual Infant Squirrel Monkeys From Isolation Call Playbacks.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1985/07//
VL - 9
IS - 1
M3 - Article
SP - 39
EP - 46
SN - 02752565
AB - Responses of six squirrel monkey (Saimiri sciureus) mothers to playback of a single call type, the ‘isolation peep.’ made by their own infants were tested after mothers and infants had been .separated for more than a week. The playback tapes were edited from tapes containing mixed vocal material recorded when infants and mothers could see but not touch each other. Mothers showed recognition of their own infants compared to other familiar infants by increases in four measures of proximity to the speaker. These data provide evidence that maternal recognition of infants by means of acoustic cues is possible when the test stimuli consist of examples of a single call type with demonstrated individuality. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SQUIRREL monkeys
KW - BEHAVIOR
KW - RECOGNITION (Psychology)
KW - SOUND production by animals
KW - PARENTAL behavior in animals
KW - RECALL (Information retrieval)
KW - ANIMAL behavior
KW - ANIMAL communication
KW - HEARING
KW - ANIMAL psychology
KW - PRIMATES
N1 - Accession Number: 12274865; Symmes, D. 1 Biben, M. 1; Affiliation: 1: National Institute of Child Health and Human Development in Bethesda, Maryland; Source Info: 1985, Vol. 9 Issue 1, p39; Subject Term: SQUIRREL monkeys; Subject Term: BEHAVIOR; Subject Term: RECOGNITION (Psychology); Subject Term: SOUND production by animals; Subject Term: PARENTAL behavior in animals; Subject Term: RECALL (Information retrieval); Subject Term: ANIMAL behavior; Subject Term: ANIMAL communication; Subject Term: HEARING; Subject Term: ANIMAL psychology; Subject Term: PRIMATES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldman, Howard H.
AU - Morrissey, Joseph P.
T1 - The Alchemy of Mental Health Policy: Homelessness and the Fourth Cycle of Reform.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/07//
VL - 75
IS - 7
M3 - Article
SP - 727
EP - 731
PB - American Public Health Association
SN - 00900036
AB - The article presents a paper that explores the fourth cycle of reform emerging in the past decade in response to the failures of community mental health and deinstitutionalization in the U.S. The new reform is urging to create community support systems, a broad network of mental health and social welfare services for care of the chronically mentally ill in noninstitutional settings. This reform movement is different because it directly addresses the needs of the chronically mentally ill rather than promising to prevent chronicity through the early treatment of acute cases and because it recognizes the problem of the chronically mentally ill as a public health and social welfare problem.
KW - MENTAL health policy
KW - HEALTH care reform
KW - PUBLIC health
KW - MENTAL health
KW - MENTAL illness
KW - PEOPLE with mental disabilities
KW - PUBLIC welfare
KW - DISEASES
KW - UNITED States
N1 - Accession Number: 4949195; Goldman, Howard H. 1 Morrissey, Joseph P. 2; Affiliation: 1: Assistant Director, National Institute of Mental Health, Mental Health Financing, 5600 Fishers Lane, Rockville, MD 20852. 2: Senior Research Sociologist, Office of Mental Health, New York State, Albany, NY.; Source Info: Jul1985, Vol. 75 Issue 7, p727; Subject Term: MENTAL health policy; Subject Term: HEALTH care reform; Subject Term: PUBLIC health; Subject Term: MENTAL health; Subject Term: MENTAL illness; Subject Term: PEOPLE with mental disabilities; Subject Term: PUBLIC welfare; Subject Term: DISEASES; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mackay, I. R.
AU - Frazer, I. H.
AU - Toh, B.-H.
AU - Pedersen, J. S.
AU - Alter, H. J.
T1 - Absence of autoimmune serological reaction in chronic non A, non B viral hepatitis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1985/07//
VL - 61
IS - 1
M3 - Article
SP - 39
EP - 43
PB - Wiley-Blackwell
SN - 00099104
AB - In 18 cases of chronic liver disease due to non-A, non-B hepatitis virus(es) in which the diagnosis was established by transmission, including chimpanzee inoculation in nine, sera were tested for the autoantibodies characteristically associated with autoimmune chronic active hepatitis. The frequency of autoantibodies to nuclear, smooth muscle, cytofilament, mitochondrial and liver membrane antigens was low, being not greater than that recorded for a normal population, and the few positive reactions obtained were at very low titre. These findings suggest that among cases of "HBsAg negative" chronic hepatitis, those due to NANB infection are distinguishable from those due to autoimmune chronic hepatitis by negative serological tests for autoantibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNE diseases
KW - HEPATITIS viruses
KW - AUTOANTIBODIES
KW - INJECTIONS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGIC diseases
KW - LIVER
KW - autoantibodies
KW - liver antigens
KW - non A
KW - non B hepatitis
KW - post-transfusion hepatitis
N1 - Accession Number: 16182885; Mackay, I. R. 1 Frazer, I. H. 1 Toh, B.-H. 2 Pedersen, J. S. 2 Alter, H. J. 3; Affiliation: 1: Clinical Research Unit of Walter and Eliza Hall Institute of Medical Research and Royal Melbourne Hospital, Melbourne. 2: Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia. 3: Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Jul1985, Vol. 61 Issue 1, p39; Subject Term: AUTOIMMUNE diseases; Subject Term: HEPATITIS viruses; Subject Term: AUTOANTIBODIES; Subject Term: INJECTIONS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGIC diseases; Subject Term: LIVER; Author-Supplied Keyword: autoantibodies; Author-Supplied Keyword: liver antigens; Author-Supplied Keyword: non A; Author-Supplied Keyword: non B hepatitis; Author-Supplied Keyword: post-transfusion hepatitis; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Inghirami, G.
AU - Tsoukas, C. D.
AU - Balow, J. E.
AU - Lambris, J. D.
T1 - Regulation of immunoglobulin secretion by Factor H of human complement.
JO - Immunology
JF - Immunology
Y1 - 1985/07//
VL - 55
IS - 3
M3 - Article
SP - 419
EP - 426
PB - Wiley-Blackwell
SN - 00192805
AB - As human B lymphocytes and macro-phages carry surface receptors for Factor H (Bi H), we investigated the possibility that this complement component regulates their function. Factor H inhibits immunoglobulin secretion by peripheral mononuclear cells (MNC) stimulated with pokeweed mitogen if present at the initiation of the cultures and at concentrations greater than 50 μg/mI. Factor H also inhibited stimulation and differentiation of purified B cells into immunoglobulin-secreting cells by Epstein-Barr virus (EBV). The inhibitory effect of Factor H was abrogated if anti-Factor H antibody was present in the cultures. EBV-transformed B-cell lines secreted less immunoglobulin if Factor H was present in the culture for at least 4 days. Culture of MNC with Factor H did not lead to the generation of suppressor I cells or macrophages. In contrast, Factor H did not cause proliferation of human peripheral total MNC or enriched I-cell or B-cell subpopulations. Also, Factor H did not inhibit the proliferation of MNC in response to several mitogens and antigens. Our results strongly indicate that Factor H is able to block human B-cell differentiation in vitro without blocking the proliferative ability of the cells. Factor H seems to act directly on the B cells through its receptor on their surface, since it inhibited T-dependent and T-independent B-cell differentiation but generated no suppressor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - MACROPHAGES
KW - MONONUCLEOSIS
KW - EPSTEIN-Barr virus
KW - SUPPRESSOR cells
KW - MITOGENS
KW - POKEWEED mitogens
KW - LYMPHOCYTES
N1 - Accession Number: 14002282; Tsokos, G. C. 1 Inghirami, G. 1 Tsoukas, C. D. 2 Balow, J. E. 1 Lambris, J. D. 3; Affiliation: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. 2: Department of Clinical Research, Scripps Clink and Research Foundation, La Jolla, California, U.S.A. 3: Department of Immunology, Scripps Clink and Research Foundation, La Jolla, California, U.S.A.; Source Info: Jul85, Vol. 55 Issue 3, p419; Subject Term: B cells; Subject Term: MACROPHAGES; Subject Term: MONONUCLEOSIS; Subject Term: EPSTEIN-Barr virus; Subject Term: SUPPRESSOR cells; Subject Term: MITOGENS; Subject Term: POKEWEED mitogens; Subject Term: LYMPHOCYTES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 1986-14888-001
AN - 1986-14888-001
AU - Optican, Lance M.
AU - Zee, David S.
AU - Chu, Fred C.
T1 - Adaptive response to ocular muscle weakness in human pursuit and saccadic eye movements.
JF - Journal of Neurophysiology
JO - Journal of Neurophysiology
JA - J Neurophysiol
Y1 - 1985/07//
VL - 54
IS - 1
SP - 110
EP - 122
CY - US
PB - American Physiological Society
SN - 0022-3077
SN - 1522-1598
N1 - Accession Number: 1986-14888-001. PMID: 4031979 Partial author list: First Author & Affiliation: Optican, Lance M.; NIH, National Eye Institute Lab of Sensorimotor Research, Bethesda, MD. Release Date: 19860601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Eye Movements; Vision Disorders. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: Jul, 1985.
AB - Findings from the present study with 4 patients (aged 42–64 yrs) with ocular muscle weakness indicate that movements of the weak eye were smaller and slower than those made by the normal eye. Saccadic adaptation consisted of a change in the relationship between saccadic amplitude and retinal error to compensate for hypometria, and pursuit adaptation consisted of an increase in the relationship between eye acceleration and the rate of motion of the image of the target on the retina during the initial phase of tracking and an increase in the velocity of tracking of a target moving at a constant velocity. (21 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - saccadic eye movements
KW - 42–64 yr old patients with ocular muscle weakness
KW - 1985
KW - Eye Movements
KW - Vision Disorders
KW - 1985
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KASLOW, RICHARD A.
T1 - AIDS Repository.
JO - Science
JF - Science
Y1 - 1985/07/05/
VL - 229
IS - 4708
M3 - Article
SP - 8
EP - 8
SN - 00368075
N1 - Accession Number: 87461134; KASLOW, RICHARD A. 1; Affiliation: 1: Epidemiology and Biometry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 7/5/1985, Vol. 229 Issue 4708, p8; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ARYA, SURESH K.
AU - CHAN GUO
AU - JOSEPHS, STEVEN F.
AU - WONG-STAAL, FLOSSIE
T1 - Trans-Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III).
JO - Science
JF - Science
Y1 - 1985/07/05/
VL - 229
IS - 4708
M3 - Article
SP - 69
EP - 73
SN - 00368075
AB - Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary DNA transcripts of viral messenger RNA's the major functional domain of the gene encoding this factor was localized to a region immediately before the env gene of the virus, a region previously thought to be noncoding. This newly identified gene consists of three exons, and its transcription into messenger RNA involves two splicing events bringing together sequences from the 5' part (287 base pairs), middle (268 base pairs), and 3' part (1258 base pairs) of the HTLV-III genome. A similar messenger RNA with a truncated second exon (70 base pairs) does not encode a trans-acting function. It is proposed that this second messenger RNA is the transcript of a gene (3'-orf) located after the env gene. Messenger RNA's were also identified for the env and gag-pol genes of HTLV-III. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461138; ARYA, SURESH K. 1 CHAN GUO 1 JOSEPHS, STEVEN F. 1 WONG-STAAL, FLOSSIE 1; Affiliation: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 7/5/1985, Vol. 229 Issue 4708, p69; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SODROSKI, JOSEPH
AU - PATARCA, ROBERTO
AU - ROSEN, CRAIG
AU - WONG-STAAL, FLOSSIE
AU - HASELTINE, WILLIAM
T1 - Location of the Trans-Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III.
JO - Science
JF - Science
Y1 - 1985/07/05/
VL - 229
IS - 4708
M3 - Article
SP - 74
EP - 77
SN - 00368075
AB - The retrovirus involved in acquired immune deficiency syndrome (HTLV-III/LAV) contains a region that is necessary for stimulation of gene expression directed by the viral long terminal repeat. This region is located between nucleotides 5365 and 5607, immediately 5' to the envelope gene. A doubly-spliced message containing this region could encode an 86-amino acid protein with structural features similar to those of nucleic acid-binding proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461166; SODROSKI, JOSEPH 1,2 PATARCA, ROBERTO 1,2 ROSEN, CRAIG 1,2 WONG-STAAL, FLOSSIE 3 HASELTINE, WILLIAM 4; Affiliation: 1: Laboratory of Biochemical Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 2: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 3: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205 4: Laboratory of Biochemical Pharmacology, Harvard Medical School; Source Info: 7/5/1985, Vol. 229 Issue 4708, p74; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Podskalny, Judith M.
AU - Takeda, Shigemasa
AU - Silverman, Robert E.
AU - Tran, Dien
AU - Carpentier, Jean-Louis
AU - Orci, Lelio
AU - Gorden, Phillip
T1 - Insulin receptors and bioresponses in a human liver cell line (Hep G-2).
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/07/15/
VL - 150
IS - 2
M3 - Article
SP - 401
EP - 407
PB - Wiley-Blackwell
SN - 00142956
AB - A newly developed human hepatoma cell line, designated Hep G-2, expresses high-affinity insulin receptors meeting all the expected criteria for classic insulin receptors. 125I-insulin binding is time-dependent and temperature-dependent and unlabeled insulin competes for the labeled hormone with a half-maximal displacement of 1–3 ng/ml. This indicates a Kd of about 10-10 M. Since Scatchard analysis of the binding data results in a curvilinear plot and unlabeled insulin accelerates the dissociation of bound hormone, these receptors exhibit the negative cooperative interactions characteristic of insulin receptors in many other cell and tissue types. Proinsulin and des(Ala, Asp)-insulin compete for 125I-insulin binding with 4% and 2%, respectively, of the potency of insulin. Anti-(insulin receptor) antibody competes fully for insulin binding. The two insulin-like growth factors, multiplication-stimulating activity and IGF-I are 2% as potent as insulin against the Hep G-2 insulin receptor. Furthermore, Hep G-2 cells respond to insulin in several bioassays. Glucose uptake, glycogen synthase, uridine incorporation into RNA and acetate incorporation into lipid are all stimulated to varying degrees by physiological concentrations of insulin. In addition, these cells ‘down-regulate’ their insulin receptor, internalize 125I-insulin and degrade insulin in a manner similar to freshly isolated rodent hepatocytes. This is the first available human liver cell line in permanent culture in which both insulin receptors and biological responses have been carefully examined. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN receptors
KW - LIVER
KW - CELL lines
KW - BINDING sites (Biochemistry)
KW - ACETATES
KW - HORMONES
N1 - Accession Number: 13872437; Podskalny, Judith M. 1 Takeda, Shigemasa 2 Silverman, Robert E. 1 Tran, Dien 3 Carpentier, Jean-Louis 3 Orci, Lelio 3 Gorden, Phillip 1; Affiliation: 1: Diabetes Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 2: Toho University School of Medicine, First Department of Internal Medicine, Tokyo 3: Institute of Histology and Embryology, University of Geneva School of Medicine; Source Info: 7/15/85, Vol. 150 Issue 2, p401; Subject Term: INSULIN receptors; Subject Term: LIVER; Subject Term: CELL lines; Subject Term: BINDING sites (Biochemistry); Subject Term: ACETATES; Subject Term: HORMONES; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katz, Stephen I.
AU - Cooper, Kevin D.
AU - Iijima, Masafumi
AU - Tsuchida, Tetsuo
T1 - The Role of Langerhans Cells in Antigen Presentation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/07/15/Jul85 Supplement
VL - 85
M3 - Article
SP - 96
EP - 98
SN - 0022202X
AB - Epidermal Langerhans cells are dendritic bone marrow-derived cells which synthesize and express Ia antigens. During the past decade, in vitro studies have demonstrated that they play a critical role in the induction of many types of T-cell responses. Specifically, Langerhans cells are effective antigen-presenting cells in allogeneic and antigen specific proliferative and cytotoxic T-cell responses. This paper reviews these functions and suggests areas of future investigations into the mechanisms involved in T-cell activation by Langerhans cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - ANTIGENS
KW - BONE marrow
KW - DENDRITIC cells
KW - T cells
KW - GRAFT versus host disease
N1 - Accession Number: 12275562; Katz, Stephen I. 1 Cooper, Kevin D. 1 Iijima, Masafumi 1 Tsuchida, Tetsuo 1; Affiliation: 1: Dermatology and Immunology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jul85 Supplement, Vol. 85, p96; Subject Term: LANGERHANS cells; Subject Term: ANTIGENS; Subject Term: BONE marrow; Subject Term: DENDRITIC cells; Subject Term: T cells; Subject Term: GRAFT versus host disease; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12275562
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawley, Thomas J.
AU - Bielory, Leonard
AU - Gascon, Pedro
AU - Yancey, Kim B.
AU - Young, Neal S.
AU - Frank, Michael M.
T1 - A Study of Human Serum Sickness.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/07/15/Jul85 Supplement
VL - 85
M3 - Article
SP - 129
EP - 132
SN - 0022202X
AB - Twelve patients with bone marrow failure, who were undergoing therapy with daily intravenous infusions of horse antithymocyte globulin, were studied for the development of serum sickness. Eleven of 12 patients developed typical signs and symptoms of serum sickness 8-13 days after the initiation of treatment. These included fever, malaise, cutaneous eruptions, arthralgias, gastrointestinal disturbances, and lymphadenopathy. Eleven of 12 patients developed high levels of circulating immune complexes during serum sickness. All 12 patients also had concomitant decreases of serum C3 and C4 levels. In addition to urticarial and/or morbilliform eruptions, 8 of 11 patients also developed a serpiginous band of erythema along the sides of the fingers, hands, toes, or feet as an early cutaneous sign of serum sickness. Direct immunofluorescence of lesional skin biopsies during serum sickness revealed deposits of immunoglobulin or complement in the walls of small cutaneous blood vessels in 3 of 5 patients. These findings indicate that circulating immune complexes play a central role in the pathophysiology of human serum sickness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM sickness
KW - HUMAN beings
KW - INTRAVENOUS therapy
KW - SKIN -- Biopsy
KW - IMMUNE system
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 12275641; Lawley, Thomas J. 1 Bielory, Leonard 2 Gascon, Pedro 2 Yancey, Kim B. 1 Young, Neal S. 2 Frank, Michael M. 3; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Clinical Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 3: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul85 Supplement, Vol. 85, p129; Subject Term: SERUM sickness; Subject Term: HUMAN beings; Subject Term: INTRAVENOUS therapy; Subject Term: SKIN -- Biopsy; Subject Term: IMMUNE system; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12275641
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pollitt, Ernesto
AU - Read, Merrill S.
T1 - Bridges between nutrition, neuroscience, and behavior.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1985/08//
VL - 42
IS - 2
M3 - Article
SP - 348
EP - 351
SN - 00029165
N1 - Accession Number: 95661723; Pollitt, Ernesto 1; Read, Merrill S. 2; Affiliations: 1: School of Public Health, The University of Texas, Houston, TX; 2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: Aug1985, Vol. 42 Issue 2, p348; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Walrath, Judy
AU - Li, Frederick P.
AU - Hoar, Shelia K.
AU - Mead, Marshall W.
AU - Fraumeni Jr., Joseph F.
T1 - Causes of Death among Female Chemists.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/08//
VL - 75
IS - 8
M3 - Article
SP - 883
EP - 885
PB - American Public Health Association
SN - 00900036
AB - Abstract: A mortality odds ratio analysis of cause of death among 347 White female members of the American Chemical Society (ACS) revealed a five-fold excess of suicide, notably by cyanide poisoning. Risk was also elevated for all cancers combined and for cancers of the breast, ovary, stomach, pancreas, and lymphatic and hematopoietic system. The excess breast and ovary cancer deaths were limited to unmarried women. (Am J Public Health 1985; 75:883-854.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEATH -- Causes
KW - CANCER in women
KW - BREAST cancer
KW - SUICIDE
KW - POISONING
KW - CYANIDES
KW - RATIO analysis
KW - UNITED States
KW - AMERICAN Chemical Society
N1 - Accession Number: 4949516; Walrath, Judy 1 Li, Frederick P. 1 Hoar, Shelia K. 1 Mead, Marshall W. 1,2 Fraumeni Jr., Joseph F. 1,3; Affiliation: 1: Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Landow 4C03, Bethesda, MD 20205 2: American Chemical Society 3: Epidemiology Section, Medical Division, E. I. DuPont de Nemours Company, Wilmington, DE; Source Info: Aug1985, Vol. 75 Issue 8, p883; Subject Term: DEATH -- Causes; Subject Term: CANCER in women; Subject Term: BREAST cancer; Subject Term: SUICIDE; Subject Term: POISONING; Subject Term: CYANIDES; Subject Term: RATIO analysis; Subject Term: UNITED States; Company/Entity: AMERICAN Chemical Society; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schoenbach, Carrie
T1 - Effects of Husband's and Wife's Social Status on Psychological Functioning.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1985/08//
VL - 47
IS - 3
M3 - Article
SP - 597
SN - 00222445
AB - This study explores the importance of each spouse's social stratification position for the other's psychological functioning, challenging long-held assumptions that husband's social-stratification position represents the stratification position of all family members. Using a national sample of 249 employed couples, effects of own and spouse's education, occupational status, and income are assessed on three dimensions of psychological functioning: ideational flexibility, self-directedness of orientation, and distress. The method of analysis involves linear structural equation models. Own stratification position is consistently more important than spouse's. Nonetheless, husband's social-stratification position does have a significant effect on wife`s ideational flexibility. Analysis of the reciprocal relationships between husband's and wife's self-directedness of orientation shows that husband's self-directedness has a much stronger effect on wife `s self-directedness than her self-directedness has on his, suggesting that the process by which stratification position of husband affects wife`s self-directedness is indirect: his social-stratification position affects his personality, and his personality in turn affects his wife's personality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUSBAND & wife
KW - SOCIAL status
KW - DOMESTIC relations
KW - SOCIAL classes
KW - SOCIAL stratification
KW - FAMILY relations
N1 - Accession Number: 5271100; Schoenbach, Carrie 1; Affiliation: 1: National Institute of Mental Health; Source Info: Aug85, Vol. 47 Issue 3, p597; Subject Term: HUSBAND & wife; Subject Term: SOCIAL status; Subject Term: DOMESTIC relations; Subject Term: SOCIAL classes; Subject Term: SOCIAL stratification; Subject Term: FAMILY relations; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06427-051
AN - 2006-06427-051
AU - Cullen, Joseph W.
T1 - Frustrations of the Oncologist.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1985/08//
VL - 30
IS - 8
SP - 656
EP - 656
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06427-051. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Cullen, Joseph W.; Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Death and Dying; Neoplasms; Radiation Therapy. Minor Descriptor: Death Education. Classification: Cancer (3293); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Torpie, Richard J. (Ed); Liegner, Leonard M. (Ed); Chang, Chu H. (Ed); Kutscher, Austin H. (Ed); Mossman, Kenneth L. (Ed); Luk, Kenneth (Ed). Radiation Therapy and Thanatology=Springfield, IL: Charles C. Thomas, 1984. 192 pp. $21.75; 1984. Page Count: 1. Issue Publication Date: Aug, 1985.
AB - Reviews the book, Radiation Therapy and Thanatology edited by Richard J. Torpie, Leonard M. Liegner, Chu H. Chang, Austin H. Kutscher, Kenneth L. Mossman, and Kenneth Luk (1984). This edited book is unlike other 'psychosocial' books on cancer in that the background and experience of the authors are relatively homogeneous. In most of the edited psychosocial books, the individual authors vary widely in perspective because the subject matter is so multifaceted. This book is like the others, however, in that very little data are presented to support the contentions made. Nevertheless, the book tells us something extremely important: that we know very little about the people who treat cancer patients and the difficulties that cancer patients have while in treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cancer patients
KW - radiation therapy
KW - thanatology
KW - 1985
KW - Death and Dying
KW - Neoplasms
KW - Radiation Therapy
KW - Death Education
KW - 1985
U2 - Torpie, Richard J. (Ed); Liegner, Leonard M. (Ed); Chang, Chu H. (Ed); Kutscher, Austin H. (Ed); Mossman, Kenneth L. (Ed); Luk, Kenneth (Ed). (1984); Radiation Therapy and Thanatology; Springfield, IL: Charles C. Thomas, 1984. 192 pp. $21.75
DO - 10.1037/024019
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Vita, Claudio
AU - Fontana, Angelo
AU - Chaiken, Irwin M.
T1 - Folding of thermolysin fragments.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/08/15/
VL - 151
IS - 1
M3 - Article
SP - 191
EP - 196
PB - Wiley-Blackwell
SN - 00142956
AB - Circular dichroism (CD) and immunochemical measurements have been used to examine conformational properties of COOH-terminal fragments [21 - 316, 206 - 316 and 225 (226) - 316 of thermolysin, and to compare these properties to those of negative thermolysin and thermolysin S, the stable partially active two-fragment complex composed of fragments 5 - 224(225) and 225(226) - 316. In aqueous solution at neutral pH, all the COOH-terminal fragments attain a native-like conformation, as judged both by one content of secondary structure deduced from far-ultraviolet CD spectra and by the recognition of rabbit polyclonal antibodies specific for the COOH-terminal region in native thermolysin. The three fragments showed reversible cooperative unfolding transitions mediated by both heat ad guanidine hydrochloride (Gdn · HCl). The phase transition curves were analyzed for Tm (temperature of half-denaturation) an Gibbs free energies (ΔGD) unfolding from native to denatured state. The observed order of thermal stability is 225(226) - 316 ≤ 206 - 316 < 121 - 316 < thermolysin S < thermolysin. The ranking of ΔGD values for the three fragments correlates with the size of each fragment. Competitive binding studies by radioimmunoassay using 14C-labelled thermolysin and affinity purified antibodies specific for native antigenic determinants in segment 206 - 316 of native thermolysin indicate that the COOH-terminal fragments adopt native-like conformations which are in equilibrium with non-native conformations. These equilibria are shifted towards the native state as the fragment size increases from 225(226) - 316, to 206 - 316, to 121 - 316. Fragment 225(226) - 316, when combined with fragment 5 - 224(225) in the thermolysin S complex, adopts a more stable native-like conformation and becomes much more antigenic. It has been shown that the degree of antigenicity of COOH-terminal fragments towards thermolysin antibodies correlates directly with their conformational stability. The results of this study are discussed is relation to the recently proposed correlation betwen antigenicity and segmental mobility of globular proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - DICHROISM
KW - IMMUNOCHEMISTRY
KW - BIOCHEMISTRY
N1 - Accession Number: 13929601; Vita, Claudio 1 Fontana, Angelo 1 Chaiken, Irwin M. 2; Affiliation: 1: Institute of Organic Chemistry, Biopolymer Research Centre of Consiglio Nazionale delle Ricerche, University of Padua 2: Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Maryland; Source Info: 8/15/85, Vol. 151 Issue 1, p191; Subject Term: IMMUNOGLOBULINS; Subject Term: DICHROISM; Subject Term: IMMUNOCHEMISTRY; Subject Term: BIOCHEMISTRY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Calvieri, Stefano
AU - Fattorossi, Andera
T1 - Cimetidine for Kaposi's sarcoma.
JO - Clinical & Experimental Dermatology
JF - Clinical & Experimental Dermatology
Y1 - 1985/09//
VL - 10
IS - 5
M3 - Letter
SP - 499
EP - 500
SN - 03076938
AB - Presents a letter to the editor related to the treatment of Kaposi's sarcoma, published in the September 1985 issue of the journal "Clinical and Experimental Dermatology."
KW - LETTERS to the editor
KW - KAPOSI'S sarcoma
KW - TREATMENT
N1 - Accession Number: 11690561; Calvieri, Stefano 1 Fattorossi, Andera 1; Affiliation: 1: Laboratory of Tumor Immunology and Biology, Building 10, Room 8BO8, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, U. S. A..; Source Info: Sep85, Vol. 10 Issue 5, p499; Subject Term: LETTERS to the editor; Subject Term: KAPOSI'S sarcoma; Subject Term: TREATMENT; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/1365-2230.ep11690561
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dennis, Barbara
AU - Shifflett, Peggy A.
T1 - A conceptual and methodological model for studying dietary habits in the community.
JO - Ecology of Food & Nutrition
JF - Ecology of Food & Nutrition
Y1 - 1985/09//
VL - 17
IS - 3
M3 - Article
SP - 253
EP - 262
SN - 03670244
AB - This paper presents a conceptual and methodological model to study dietary habits in the community. This effort is in response to the need to develop multi‐dimensional concepts of dietary behavior in free‐living populations and innovative methods appropriate for their study. A theoretical construct, dietary habit, is presented. After describing current methods used in both social and nutrition research, a model is suggested for integrating them in epidemiological research design to study dietary habit. This model is adapted from the sociological technique of triangulation. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Ecology of Food & Nutrition is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75863365; Dennis, Barbara 1; Shifflett, Peggy A. 2; Affiliations: 1: National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland; 2: Department of Sociology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Issue Info: Sep1985, Vol. 17 Issue 3, p253; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/03670244.1985.9990900
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DP - EBSCOhost
DB - eih
ER -
TY - RPRT
AU - Ansel, John C.
AU - Mountz, John
AU - Steinberg, Alfred D.
AU - DeFabo, Edward
AU - Green, Ira
T1 - Effects of UV Radiation on Autoimmune Strains of Mice: Increased Mortality and Accelerated Autoimmunity in BXSB Male Mice.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/09//
VL - 85
IS - 3
M3 - Report
SP - 181
EP - 186
SN - 0022202X
AB - Systemic lupus erythematosus is an immunologically mediated autoimmune disease which has been reported to be aggravated by certain environmental agents such as ultraviolet irradiation (UV). To further investigate this interaction, we examined the consequences of UV exposure on the autoimmune process of several strains of autoimmune mice. Strains of age- and sex-matched, 3- to 4-month old, autoimmune (MRL-lpr/lpr, (NZB× NZW)F1, BXSB) and nonautoimmune (BALB/c, B10.A) mice were shaved and exposed to an acute (2 h daily × 7 days) and a chronic (3 h/weekly × 4 weeks) dose of UV (FS40 lamps, 2 mJ/cm2/s). UV-induced changes in survival, autoantibody production, splenic B-cell activity, and target organ pathology were examined. After an acute UV exposure there were (10/15) deaths in the UV BXSB males and 4/15 in the UV BXSB females, compared to 1/15 in the non-UV BXSB male group and (0/15 in the non-UV BXSB females. No deaths occurred in the other UV autoimmune or nonautoimmune groups. Likewise, chronic UV resulted in increased UV BXSB male mortality 13/15 compared to UV BXSB females 2/15 and non-UV BXSB males and females. No deaths occurred in the other autoimmune (MRL-lpr/lpr, (NZB×NZW)F1) or nonautoimmune (BALB/c, B10.A) strains, after chronic UV exposure. Equivalent doses of Mylar-filtered FS40 UV (UVB deleted) resulted in no deaths in the UV BXSB male group. Acute and chronic UV also resulted in a significant increase in serum single-stranded DNA antibody production, splenic poly-clonal B-cell activity, and renal glomerular inflammatory changes in the UV BXSB male mice. Thus, UV resulted in premature death and accelerated autoimmunity in UV BXSB males and may serve as a useful model for phototoxicity in autoimmunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNE diseases
KW - MICE
KW - AUTOIMMUNITY
KW - SYSTEMIC lupus erythematosus
KW - ULTRAVIOLET radiation
KW - AUTOANTIBODIES
N1 - Accession Number: 12276652; Ansel, John C. 1 Mountz, John 2 Steinberg, Alfred D. 2 DeFabo, Edward 3 Green, Ira 1; Affiliation: 1: Laboratory of Immunology, George Washington School of Medicine, Washington, D.C., U.S.A. 2: National Institute of Allergy and Infectious Diseases, and Cellular Immunology Section, Arthritis and Rheumatism Branch, George Washington School of Medicine, Washington, D.C., U.S.A. 3: National Institute of Arthritis, Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, and Department of Dermatology. George Washington School of Medicine, Washington, D.C., U.S.A.; Source Info: Sep85, Vol. 85 Issue 3, p181; Subject Term: AUTOIMMUNE diseases; Subject Term: MICE; Subject Term: AUTOIMMUNITY; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: ULTRAVIOLET radiation; Subject Term: AUTOANTIBODIES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Report
L3 - 10.1111/1523-1747.ep12276652
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Piegorsch, Walter W.
T1 - Average-Width Optimality for Confidence Bands in Simple Linear Regression.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/09//
VL - 80
IS - 391
M3 - Article
SP - 692
SN - 01621459
AB - The problem of constructing optimal confidence bands for a simple linear regression over the whole real line is considered. Optimality is defined as minimization of the average width of the bands weighted by a normalized function. This weight function is presented as an indicator of experimental interest in the varying width of the band. A comparison between the commonly seen hyperbolic bands and segmented-line bands is presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - SAMPLING (Statistics)
KW - STATISTICAL hypothesis testing
KW - MATHEMATICAL statistics
KW - CONFIDENCE intervals
KW - EXPONENTIAL functions
KW - Constrained minimization.
KW - Prior weight functions
KW - Simultaneous confidence intervals
N1 - Accession Number: 4608242; Piegorsch, Walter W. 1; Affiliations: 1: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep85, Vol. 80 Issue 391, p692; Thesaurus Term: REGRESSION analysis; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MATHEMATICAL statistics; Subject Term: CONFIDENCE intervals; Subject Term: EXPONENTIAL functions; Author-Supplied Keyword: Constrained minimization.; Author-Supplied Keyword: Prior weight functions; Author-Supplied Keyword: Simultaneous confidence intervals; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Parke, Robert
T1 - Statistical Abstract of the United States (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/09//
VL - 80
IS - 391
M3 - Book Review
SP - 771
SN - 01621459
AB - Reviews the book "Statistical Abstract of the United States: 1984," 104th ed.
KW - STATISTICS
KW - NONFICTION
KW - 1984: The National Data Book (Book)
N1 - Accession Number: 4608704; Parke, Robert 1; Affiliations: 1: National Cancer Institute.; Issue Info: Sep85, Vol. 80 Issue 391, p771; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: 1984: The National Data Book (Book); Number of Pages: 3/4p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Berzofsky, Jay A.
T1 - Intrinsic and Extrinsic Factors in Protein Antigenic Structure.
JO - Science
JF - Science
Y1 - 1985/09/06/
VL - 229
IS - 4717
M3 - Article
SP - 932
EP - 940
SN - 00368075
AB - Recent advances in the preparation of synthetic peptide vaccines and the use of synthetic peptides as probes of antigenic structure and function have led to renewed interest in the prediction of antigenic sites recognized by antibodies and T cells. This review focuses on antibodies. Features intrinsic to the antigen, such as hydrophilicity and mobility, may be useful in the selection of amino acid sequences of the native protein that will elicit antibodies cross-reacting with peptides, or sequences which, as peptides, will be more likely to elicit antibodies cross-reactive with the native protein. Structural mobility may also contribute to protein-protein interactions in general. However, the entire accessible surface of a protein is likely to be detectable by a large enough panel of antibodies. Which of these antibodies are made in any individual depends on factors extrinsic to the antigen molecule, host factors such as self-tolerance, immune response genes, idiotype networks, and the immunoglobulin structural gene repertoire. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461206; Berzofsky, Jay A. 1; Affiliation: 1: Senior Investigator, Metabolism Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205; Source Info: 9/6/1985, Vol. 229 Issue 4717, p932; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KING, C. RICHTER
AU - KRAUS, MATTHIAS H.
AU - AARONSON, STUART A.
T1 - Amplification of a Novel v-erbB-Related Gene in a Human Mammary Carcinoma.
JO - Science
JF - Science
Y1 - 1985/09/06/
VL - 229
IS - 4717
M3 - Article
SP - 974
EP - 976
SN - 00368075
AB - The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to verbB but amplified in a manner that appeared to distinguish itfrom the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461209; KING, C. RICHTER 1 KRAUS, MATTHIAS H. 1 AARONSON, STUART A. 1; Affiliation: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20205; Source Info: 9/6/1985, Vol. 229 Issue 4717, p974; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vuust, Jens
AU - Sobel, Mark E.
AU - Martin, George R.
T1 - Regulation of type I collagen synthesis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/09/16/
VL - 151
IS - 3
M3 - Article
SP - 449
EP - 453
PB - Wiley-Blackwell
SN - 00142956
AB - The type I collagen molecule contains two α1(I) chains and one α2(I) chain. Previous investigations, using embryonic chick calvaria have indicated that the two chains are synthesized in a 2: 1 ratio which is controlled at a pretranslational level, since the cells contain twice as much translatable proα1(I) mRNA as proα2(I) mRNA. The present report describes hybridization analyses of the cellular levels of total cellular RNAs coding for the proα1(1) and proα2(I) chains, using as probes two cloned cDNAs complementary to chick proα1(I) and proα2(I) mRNA, respectively. Total cellular RNA was extracted from embryonic chick calvaria, proα1(I) and proα1(I) RNA sequences were quantified by Northern hybridization using conditions ensuring that hybridization efficiency and specific radioactivity were the same for the two probes. Similar analyses were carried out on RNA extracted from calvaria with different levels of collagen synthesis after culture in the presence or absence of ascorbic acid. The results for all samples analyzed indicate that total cellular proα1(I) and proα2(I) mRNAs are present in a 2:1 ratio which is maintained even during variations in collagen synthesis rate. There is no evidence for regulation mediated by different rates of processing of mRNA precursors, although preferential degradation of the proα2(I) gene transcript cannot be excluded. Thus, the synthesis of type I procollagen chains is presumably coordinated by transcriptional control. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLAGEN
KW - EXTRACELLULAR matrix proteins
KW - MESSENGER RNA
KW - HYBRIDIZATION
KW - NUCLEIC acids
KW - BREEDING
N1 - Accession Number: 15801489; Vuust, Jens 1 Sobel, Mark E. 1 Martin, George R. 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda. Maryland; Source Info: 9/16/85, Vol. 151 Issue 3, p449; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: MESSENGER RNA; Subject Term: HYBRIDIZATION; Subject Term: NUCLEIC acids; Subject Term: BREEDING; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Russell-Briefel, Ronette
AU - Ezzati, Trena
AU - Perlman, Jeffrey
T1 - Prevalence and Trends in Oral Contraceptive Use in Premenopausal Females Ages 12-54 Years, United States, 1971-80.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/10//
VL - 75
IS - 10
M3 - Article
SP - 1173
EP - 1176
PB - American Public Health Association
SN - 00900036
AB - Abstract: Data from the second National Health and Nutrition Examination Survey (NHANES II) were analyzed to estimate the prevalence of oral contraceptive use in the United States. 1976-80. The overall unadjusted prevalence of oral contraceptive use was 16.7 per ¢ for premenopausal females ages 12-54 years (19.2 per ¢ for ages 15-44 years), Approximately 8.7 million females (95 per ¢ confidence interval, 6.9-10.5 million) were oral contraceptive users at the midpoint of NHANES II (March 19781). Comparison to the NHANES I, conducted in 1971-74, indicated a stable number of overall oral contraceptive users in the US population during the 1970s, with shifts in certain age groups: oral contraceptive use increased for females ages 12-19 years and decreased for females ages 20-49 years. The overall age-adjusted prevalences indicated a 2 per ¢ 195 per ¢ CI, 0.2-3.8 per ¢) decline in oral contraceptive use from the early to the Late 1970s, The NHANES provides comparative data and supports findings from another national survey showing a decrease in the per ¢ of females using oral contraceptives during 1973-82. Trends in oral contraceptive use are also presented by race. poverty level, rural-urban residence, marital status, and education level. (Am J Public Health 1985:75:1173-1176.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORAL contraceptives
KW - CONTRACEPTIVE drugs
KW - WOMEN
KW - RACE
KW - MARITAL status
KW - EDUCATION
KW - SOCIAL status
KW - CONTRACEPTION
KW - UNITED States
N1 - Accession Number: 4947756; Russell-Briefel, Ronette 1 Ezzati, Trena 1 Perlman, Jeffrey 2; Affiliation: 1: National Center for health Statistics. 2: National Institute of Child Health and Human Development.; Source Info: Oct85, Vol. 75 Issue 10, p1173; Subject Term: ORAL contraceptives; Subject Term: CONTRACEPTIVE drugs; Subject Term: WOMEN; Subject Term: RACE; Subject Term: MARITAL status; Subject Term: EDUCATION; Subject Term: SOCIAL status; Subject Term: CONTRACEPTION; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tietz, Dietmar
T1 - Characterization of a novel (--+)-abscisic acid metabolite.
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1985/10//
VL - 65
IS - 2
M3 - Article
SP - 171
EP - 176
SN - 00319317
AB - By application of (±)-abscisic acid and (±)-[1-14C]-abscisic acid to pea seedlings (Pisum sativum L. cv. Kleine Rheinländerin) a new abscisic acid metabolite (Pisumic acid, PISA) could be isolated and structurally characterized by combined gas chromatography-mass spectrometry. From data of exact mass determination, it is suggested that the metabolite has the tentative structure of 4-dihydroabscisic acid with a hydroxylated methyl: group at C-6'. That this could be evidence for an alternative pathway of abscisic acid metabolism which was suggested earlier by Walton et al. [PIanta 112: 87-90 (1973)] is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEAS
KW - METABOLITES
KW - ABSCISIC acid
KW - MASS spectrometry
KW - SEEDLINGS
KW - PLANT metabolism
KW - 4'-desoxy-abscisic acid
KW - 4'-dihydro-abscisic acid
KW - Pisum sativum.
KW - Abscisic acid metabolism
KW - mass spectrometry
KW - Pisumic acid
N1 - Accession Number: 12906263; Tietz, Dietmar 1; Affiliation: 1: Section on Macromolecular Analysis, Lab. of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National institutes of Health, Bethesda, MD 20205, USA.; Source Info: Oct85, Vol. 65 Issue 2, p171; Subject Term: PEAS; Subject Term: METABOLITES; Subject Term: ABSCISIC acid; Subject Term: MASS spectrometry; Subject Term: SEEDLINGS; Subject Term: PLANT metabolism; Author-Supplied Keyword: 4'-desoxy-abscisic acid; Author-Supplied Keyword: 4'-dihydro-abscisic acid; Author-Supplied Keyword: Pisum sativum.; Author-Supplied Keyword: Abscisic acid metabolism; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: Pisumic acid; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 111130 Dry Pea and Bean Farming; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1399-3054.ep12906263
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2014-02372-002
AN - 2014-02372-002
AU - Backer, Thomas E.
AU - Levine, Irene Shifren
T1 - Building bridges: Program and peer consultation to enhance services to the severely mentally ill.
JF - Psychosocial Rehabilitation Journal
JO - Psychosocial Rehabilitation Journal
Y1 - 1985/10//
VL - 9
IS - 2
SP - 3
EP - 13
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN - 0147-5622
N1 - Accession Number: 2014-02372-002. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Backer, Thomas E.; Human Interaction Research Institute, Los Angeles, CA, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Organizations; Peers; Professional Consultation; Psychosocial Rehabilitation. Minor Descriptor: Severity (Disorders). Classification: Rehabilitation (3380). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Oct, 1985.
AB - Psychosocial rehabilitation agencies are beginning to identify and use opportunities for consultation, both on a peer level with other agencies and with organizations that have some service responsibility or contact with severely mentally ill people. This article reviews recent changes in services for the chronically mentally ill that have stimulated the need for consultation; provides an overview of peer and program consultation; provides an overview of peer and program consultation on chronic mental illness; and suggests opportunities for psychosocial rehabilitation agency staff to develop consulting opportunities in their own community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial rehabilitation agencies
KW - severely mentally ill
KW - program consultation
KW - peer consultation
KW - 1985
KW - Mental Disorders
KW - Organizations
KW - Peers
KW - Professional Consultation
KW - Psychosocial Rehabilitation
KW - Severity (Disorders)
KW - 1985
U1 - Sponsor: National Institute of Mental Health, Office of State and Community Liaison, US. Recipients: No recipient indicated
U1 - Sponsor: Office of Prevention. Recipients: No recipient indicated
DO - 10.1037/h0099141
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11626-001
AN - 2009-11626-001
AU - Pedersen, Frank A.
T1 - Leon J. Yarrow (1921–1982).
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1985/10//
VL - 40
IS - 10
SP - 1137
EP - 1137
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2009-11626-001. Partial author list: First Author & Affiliation: Pedersen, Frank A.; National Institute of Child Health and Human Development, US. Release Date: 20090810. Correction Date: 20100125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Obituary. Language: English. Major Descriptor: Psychologists. Minor Descriptor: Childhood Development. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Page Count: 1. Issue Publication Date: Oct, 1985.
AB - Presents an obituary for Leon J. Yarrow. Yarrow was born on September 30, 1921, in Shenandoah, Pennsylvania. His father died when Leon was very young, and he experienced some of the transitions in attachments and care that may well have influenced his life-long research interest in the importance of early experience for the developing child. At age 15 Leon entered the University of Pennsylvania, where he majored in psychology. In 1951 Leon accepted the first research position that was made available in the old U.S. Children's Bureau. He initiated a longitudinal investigation of adopted children that focused on the consequences of the infant's transition from foster care to the adoptive parents. As his findings became known, social work practice was modified to favor adoption at the earliest ages. Leon spent a major part of his career at the National Institutes of Health (NIH). His associates there were uniformly touched by his personal warmth, his unrelentingly high standards for developmental studies, and the conceptual elegance with which he grasped problems. Leon died July 28, 1982, of a heart attack, the day before he planned to embark on a summer vacation with his family. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Leon Yarrow
KW - psychologists
KW - child development
KW - 1985
KW - Psychologists
KW - Childhood Development
KW - 1985
DO - 10.1037/h0092156
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2015-21770-001
AN - 2015-21770-001
AU - Lansky, Lester L.
AU - List, Marcy A.
AU - Lansky, Shirley B.
AU - Cohen, Michael E.
AU - Sinks, Lucius F.
T1 - Toward the development of a Play Performance Scale for Children (PPSC).
JF - Cancer
JO - Cancer
JA - Cancer
Y1 - 1985/10/01/
VL - 56
IS - 7, Suppl
SP - 1837
EP - 1840
CY - US
PB - John Wiley & Sons
SN - 0008-543X
SN - 1097-0142
AD - Lansky, Lester L., Department of Neurology, University of Illinois College of Medicine, 912 South Wood Street, 855-N, NPI, Chicago, IL, US, 60612
N1 - Accession Number: 2015-21770-001. PMID: 4027922 Partial author list: First Author & Affiliation: Lansky, Lester L.; Department of Neurology, University of Illinois, IL, US. Release Date: 20150525. Correction Date: 20161024. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: American Cancer Society Conference: Pediatric Brain Tumor Workshop, Jun, 1984, Niagara-on-the-Lake, ON, Canada. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Brain Neoplasms; Childhood Play Development; Developmental Age Groups; Developmental Measures; Test Construction. Minor Descriptor: Childhood Play Behavior; Psychological Assessment; Rating Scales; Test Reliability; Test Validity. Classification: Developmental Scales & Schedules (2222); Cancer (3293). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Play Performance Scale for Children DOI: 10.1037/t05801-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Oct 1, 1985.
AB - Performance scales (i.e., Karnofsky), as they measure quality of life, have been used effectively as an integral part of repeated assessment of adult cancer patients for the last several years. An equally concise measure of performance has not been developed for children. The task of developing a scale to assess performance in infants, toddlers, school-age children, and adolescents is formidable, as the activity measured should be of equal merit at each age level. Although all childhood cancer patients could benefit from a simple-to-administer, rapid assessment, children with brain tumors have the greatest need for a repeated measure of performance. The goal then, is to develop a simplified set of criteria that can be used for assessment of children with brain tumors during hospitalization, at the time of clinic visits, and/or at the time of diagnostic procedures when the patient is in a reasonable state of health. The assessment should be able to be performed by nonprofessional persons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - performance scale
KW - childhood cancer patients
KW - infants
KW - toddlers
KW - school-age children
KW - adolescents
KW - brain tumors
KW - 1985
KW - Brain Neoplasms
KW - Childhood Play Development
KW - Developmental Age Groups
KW - Developmental Measures
KW - Test Construction
KW - Childhood Play Behavior
KW - Psychological Assessment
KW - Rating Scales
KW - Test Reliability
KW - Test Validity
KW - 1985
DO - 10.1002/1097-0142(19851001)56:7+<1837::AID-CNCR2820561324>3.0.CO;2-Z
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Forman, Michele R.
AU - Fetterly, Karen
AU - Graubard, Barry I.
AU - Wooton, Karen G.
T1 - Exclusive breast-feeding of newborns among married women in the United States: the National Natality Surveys of 1969 and 1980.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1985/11//
VL - 42
IS - 5
M3 - Article
SP - 864
EP - 869
SN - 00029165
AB - Questions about infant feeding practices after birth were included in 1969 and 1980 National Natality Surveys (NNS). At 3-6 mo postpartum, NNS questionnaires were mailed to mothers of live infants born in wedlock, and responses were weighted to permit national estimates. Based on the NNS, the proportion of women who were exclusively breast-feeding newborns in the United States was significantly lower in 1969 (19% of white women, 9% of black women) compared with 1980 (51% of white women, 25% of black women). In 1969, the highest percentages of exclusive breast-feeding were observed among white women ≤ 34 yr, of parity ≤ 3 and > 7, and of higher than lower socioeconomic groups; and among black women ≥ 30 yr, of parity ≥ 4, and of lower than higher socioeconomic groups. Among women in both races in 1980, more primiparae than multiparae and the more highly educated were breast-feeding. More white than black women exclusively breastfed within each birthweight and each sociodemographic characteristic in 1980; therefore, the racial differences remained across these factors. These findings are compared with results of the Ross Laboratories surveys of infant feeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Breastfeeding (Humans)
KW - Sociodemographic factors
KW - Socioeconomic factors
KW - Married women -- Attitudes
KW - United States
KW - birthweight
KW - bottle-feeding
KW - Breast-feeding
KW - sociodemographic
N1 - Accession Number: 90624271; Forman, Michele R. 1; Fetterly, Karen 2; Graubard, Barry I. 2; Wooton, Karen G. 1; Affiliations: 1: Division of Nutrition, Center for Health Promotion and Education, Centers for Disease Control, Atlanta. GA; 2: National Institute for Child Health and Human Development, Bethesda, MD; Issue Info: Nov1985, Vol. 42 Issue 5, p864; Subject Term: Breastfeeding (Humans); Subject Term: Sociodemographic factors; Subject Term: Socioeconomic factors; Subject Term: Married women -- Attitudes; Subject: United States; Author-Supplied Keyword: birthweight; Author-Supplied Keyword: bottle-feeding; Author-Supplied Keyword: Breast-feeding; Author-Supplied Keyword: sociodemographic; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simopoulos, Artemis P.
T1 - The nutritional aspects of hypertension.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1985/11//
VL - 42
IS - 5
M3 - Article
SP - 909
EP - 912
SN - 00029165
AB - The article discusses the various papers presented at the Workshop on Nutrition and Hypertension, which was held on March 12-14, 1984. Topics discussed include laboratory methods in nutrition research, nutritional factors involved in the pathogenesis of hypertension, and the role of sodium in hypertension. Researchers David M. Hegsted, John R. Gill, and Richard J. Havlik participated in the workshop.
KW - Hypertension -- Nutritional aspects
KW - Hypertension -- Congresses
KW - Sodium -- Physiological effect
KW - Nutrition research
KW - Gill, John R.
N1 - Accession Number: 90624281; Simopoulos, Artemis P. 1; Affiliations: 1: Chairman, Nutrition Coordinating Committee, National Institutes of Health, Building 31, Room 4B59, Bethesda, MD 20892; Issue Info: Nov1985, Vol. 42 Issue 5, p909; Subject Term: Hypertension -- Nutritional aspects; Subject Term: Hypertension -- Congresses; Subject Term: Sodium -- Physiological effect; Subject Term: Nutrition research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: Gill, John R.; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bergner, Lawrence
AU - Hallstrom, Alfred P.
AU - Bergner, Marilyn
AU - Eisenberg, Mickey S.
AU - Cobb, Leonard A.
T1 - Health Status of Survivors of Cardiac Arrest and of Myocardial Infarction Controls.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/11//
VL - 75
IS - 11
M3 - Article
SP - 1321
EP - 1323
PB - American Public Health Association
SN - 00900036
AB - Abstract: We interviewed 308 survivors of out-of-hospital cardiac arrest and matched controls who had suffered a myocardial infarction. The Sickness Impact Profile (SIP) scores of controls were somewhat lower (better) than those of cases, but responses of cases and controls to additional questions about stair climbing, irritability and mood were virtually identical. Half as many (18 per cent) controls as cases (38 per cent) reported poorer memory function; nevertheless, 63 per cent of cases and 79 per cent of controls who had been working outside the home at the time of the event were employed at the time of the interview. (Am J Public Health 1985; 75:1321-1323.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIAC arrest
KW - CARDIAC patients
KW - MYOCARDIAL infarction
KW - SICKNESS Impact Profile
KW - HEALTH status indicators
KW - MEMORY
N1 - Accession Number: 4947495; Bergner, Lawrence 1 Hallstrom, Alfred P. 2 Bergner, Marilyn 3 Eisenberg, Mickey S. 4 Cobb, Leonard A. 5; Affiliation: 1: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 2: Research Professor, Department of Biostatistics, University of Washington 3: Professor of Health Services, University of Washington 4: Associate Professor, Department of Medicine, University of Washington, Seattle, WA 98195 5: Professor, Department of Medicine, University of Washington; Source Info: Nov85, Vol. 75 Issue 11, p1321; Subject Term: CARDIAC arrest; Subject Term: CARDIAC patients; Subject Term: MYOCARDIAL infarction; Subject Term: SICKNESS Impact Profile; Subject Term: HEALTH status indicators; Subject Term: MEMORY; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Joanne
AU - Slomczynski, Kazimierz M.
AU - Kohn, Melvin L.
T1 - Continuity of Learning-Generalization: The Effect of Job on Men's Intellective Process in the United States and Poland.
JO - American Journal of Sociology
JF - American Journal of Sociology
Y1 - 1985/11//
VL - 91
IS - 3
M3 - Article
SP - 593
EP - 615
SN - 00029602
AB - Job conditions have a direct effect on whether workers will be ideologically flexible or conservative; likewise, workers' intellective processes affect choices of working conditions throughout adult life.
KW - AUTONOMY (Psychology)
KW - OCCUPATIONS
KW - INTELLECT
KW - REGRESSION analysis
KW - MULTIPLE regression analysis
KW - OLDER people -- United States
KW - EMPLOYEES
KW - WORK environment
KW - MEN
KW - IDEOLOGY
KW - POLAND
KW - UNITED States
KW - EDUCATION, TRAINING, AND CAREER DEVELOPMENT
N1 - Accession Number: 15648903; Miller, Joanne 1; Slomczynski, Kazimierz M. 2; Kohn, Melvin L. 3; Affiliations: 1 : National Institute of Mental Health and Russell Sage Foundation; 2 : National Institute of Mental Health and University of Warsaw; 3 : National Institute of Mental Health and Johns Hopkins University; Source Info: Nov85, Vol. 91 Issue 3, p593; Historical Period: 1964 to 1978; Subject Term: AUTONOMY (Psychology); Subject Term: OCCUPATIONS; Subject Term: INTELLECT; Subject Term: REGRESSION analysis; Subject Term: MULTIPLE regression analysis; Subject Term: OLDER people -- United States; Subject Term: EMPLOYEES; Subject Term: WORK environment; Subject Term: MEN; Subject Term: IDEOLOGY; Subject: POLAND; Subject: UNITED States; Author-Supplied Keyword: EDUCATION, TRAINING, AND CAREER DEVELOPMENT; Number of Pages: 23p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - NEWS
AU - Moshell, Alan N.
T1 - Sources of Research Support: Overview and Discussion.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/11//
VL - 85
IS - 5
M3 - Editorial
SP - 391
EP - 393
SN - 0022202X
AB - This article focuses on research support for a survey conducted by "The Society for Investigative Dermatology" on the scope of skin disease. The survey reported revealed that the National Institutes of Health (NIH) provided almost two-thirds of such support. The survey also indicated that approximately three out of every five approved NIH applications were funded. However, the NIH has made an attempt to encourage young scientists into biomedical research careers by modifying existing support mechanisms and developing new support mechanisms in the areas of research training.
KW - RESEARCH grants
KW - SURVEYS
KW - SKIN diseases
KW - TRAINING
KW - SCIENTISTS
KW - SOCIETY for Investigative Dermatology
N1 - Accession Number: 12277049; Moshell, Alan N. 1; Affiliation: 1: National Institutes of Health Bethesda, Maryland.; Source Info: Nov85, Vol. 85 Issue 5, p391; Subject Term: RESEARCH grants; Subject Term: SURVEYS; Subject Term: SKIN diseases; Subject Term: TRAINING; Subject Term: SCIENTISTS; Company/Entity: SOCIETY for Investigative Dermatology; NAICS/Industry Codes: 813219 Other Grantmaking and Giving Services; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1111/1523-1747.ep12277049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tomita, Yasushi
AU - Montague, Paul M.
AU - Hearing, Vincent J.
T1 - Anti-T4-Tyrosinase Monoclonal Antibodies-Specific Markers for Pigmented Melanocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/11//
VL - 85
IS - 5
M3 - Article
SP - 426
EP - 430
SN - 0022202X
AB - Tyrosinase (EC 1.14.18.1) is the enzyme essential to pigment formation in mammals; this enzyme is specifically localized in melanocytes, which occur primarily in the skin, hair bulbs, and eyes. Three hybridomas, TMH1, TMH-2, and TMH-3, which produce monoclonal antibodies directed against tyrosinase, were obtained by fusion of SP2/0 myeloma cells and lymphocytes of rats hyperimmunized with purified melanosomal tyrosinase. These three monoclonal antibodies bound specifically to the mature, T4 form of tyrosinase, and did not bind to either of the precursor forms (T1 or T2) of the enzyme, which demonstrates that further posttranslational modifications of this enzyme occur which had not previously been detected. Epitope mapping studies have shown that at least two different immunologic determinants on tyrosinase are recognized by these antibodies. All three antibodies showed positive immunofluorescence staining of pigmented murine melanocytes from various sources, including B16 melanoma growing in vivo and in vitro, epidermal melanocytes, and retinal melanocytes. The antibodies did not cross-react with unpigmented cells, including K1735 amelanotic melanoma cells, albino murine skin or eye tissue, fibrosarcoma cells, rat fibroblasts, or epidermal keratinocytes. These monoclonal antibodies are sensitive, highly specific probes for pigmented mammalian melanocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOL oxidase
KW - ENZYMES
KW - IMMUNOGLOBULINS
KW - MELANOCYTES
KW - LYMPHOCYTES
KW - MELANOMA
N1 - Accession Number: 12277121; Tomita, Yasushi 1 Montague, Paul M. 2 Hearing, Vincent J. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov85, Vol. 85 Issue 5, p426; Subject Term: PHENOL oxidase; Subject Term: ENZYMES; Subject Term: IMMUNOGLOBULINS; Subject Term: MELANOCYTES; Subject Term: LYMPHOCYTES; Subject Term: MELANOMA; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277121
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Digiovanna, John J.
AU - Fletcher, R. Theodore
AU - Chader, Gerald J.
T1 - Qualitative and Quantitative Analysis of Cytosol Retinoid Binding Proteins in Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/11//
VL - 85
IS - 5
M3 - Article
SP - 460
EP - 464
SN - 0022202X
AB - The distribution of the cytosol retinol and retinoic acid binding proteins are known to vary greatly within the different layers of the eye, a retinoid target organ. We have analyzed the cytosol retinoid binding from adult human skin, another retinoid target organ, and examined the relative contribution of the epidermis and dermis to the total retinoid binding. The mean specific activity of [3H]retinol (0.52 ± 0.06 pmol/mg protein) and [3H]retinoic acid (3.20 ± 0.45 pmol/mg protein) binding to cytosol preparations from different specimens of adult human skin was determined. On the ayerage these skins bound 7-fold more retinoic acid than retinol. When skin was treated with EDTA and separated into epidermal and dermal fractions, [3H]retinol and [3H]retinoic acid binding was found in the cytosol derived from epidermis (0.36 ±0.03 pmol/mg protein, 3.69 ± 0.13 pmol/mg protein, respectively) but not from dermis. To confirm that the absence of dermal binding was not due to loss during the EDTA separation, we assayed skin keratomed at 0.1, 0.2, and 0.3 mm. The skin obtained at 0.1 mm was upper epidermis and exhibited binding for both retinol and retinoid acid. The 0.2 mm skin, which added lower epidermis but little dermal contamination, had higher specific activities for both retinol and retinoic acid binding. The 0.3 mm skin which added primarily dermis, had lower specific activities for binding both retinoids. This is consistent with the concept that the epidermis is responsible for the majority of retinoid binding in adult human skin obrained from the lower limb. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN A
KW - CARRIER proteins
KW - RETINOIDS
KW - EPIDERMIS
KW - SKIN
KW - ORGANS (Anatomy)
N1 - Accession Number: 12277185; Digiovanna, John J. 1 Fletcher, R. Theodore 2 Chader, Gerald J. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Nov85, Vol. 85 Issue 5, p460; Subject Term: VITAMIN A; Subject Term: CARRIER proteins; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Subject Term: SKIN; Subject Term: ORGANS (Anatomy); Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277185
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Somerman, M.J.
AU - Kagermer, A.S.
AU - Bowers, M.R.
AU - Fox, P.C.
T1 - In vitro attachment of bacteria to extracts of cementum.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1985/11//
VL - 14
IS - 10
M3 - Article
SP - 793
EP - 799
SN - 03009777
AB - Cementum is a specialized mineralized tissue providing for the attachment of periodontal fibers to the root surface of a tooth. In periodontal disease this connective tissue attachment to the cemental surface is lost. The ability of bacteria to adhere to the root surface, an initial event in the disease process, may be influenced by the organic matrix of cementum. Therefore, an in vitro assay of cell attachment was modified to study bacterial adherence to protein extracts of cementum. Petri dishes coated with the extracts were pre-incubated in culture media and then bacteria were added. Using this assay, Capnocytophaga-like species, a gram negative bacterium implicated in periodontal disease, attached preferentially to dishes coated with cemental extracts when compared with Type I collagen or uncoated dishes. This assay system should prove beneficial for studying the attachment of various microorganisms to protein extracts of both normal and diseased cementum, as well as providing insight into the unique attachment properties of cementum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CEMENTUM
KW - BACTERIAL adhesion
KW - COLLAGEN
KW - RATS
N1 - Accession Number: 11472565; Somerman, M.J. 1 Kagermer, A.S. 2 Bowers, M.R. 1 Fox, P.C. 1; Affiliation: 1: Clinical Investigations and Patient Care Branch, National Institutes of Health, Bethesda 2: Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda; Source Info: Nov85, Vol. 14 Issue 10, p793; Subject Term: CEMENTUM; Subject Term: BACTERIAL adhesion; Subject Term: COLLAGEN; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0714.ep11472565
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lowy, Douglas R.
T1 - Oncogenes Are Here to Stay.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/12//
VL - 85
IS - 6
M3 - Editorial
SP - 495
EP - 497
SN - 0022202X
AB - Some cancers might represent the consequence of one or several discrete genetic changes in the tumor cells. Studies of xeroderma pigmentosum cells revealed genetic lesions that predispose cells to be more susceptible to the carcinogenic effects of ultraviolet radiation. As often happens, technical innovations have led to identification and characterization of these genes. Tumor virologists carried out the initial studies of cellular oncogenes. It bad been recognized for many years that certain proteins encoded by the strongly transforming retroviruses have the capacity to directly induce tumorigenic transformation of cultured cells and endow these viruses with their high oncogenic potentials.
KW - TUMORS
KW - ONCOGENES
KW - XERODERMA pigmentosum
KW - VIROLOGISTS
KW - RETROVIRUSES
KW - PROTEINS
N1 - Accession Number: 12277286; Lowy, Douglas R. 1; Affiliation: 1: Laboratory of Cellular Oncology National Cancer Institute Bethesda, Maryland.; Source Info: Dec85, Vol. 85 Issue 6, p495; Subject Term: TUMORS; Subject Term: ONCOGENES; Subject Term: XERODERMA pigmentosum; Subject Term: VIROLOGISTS; Subject Term: RETROVIRUSES; Subject Term: PROTEINS; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1111/1523-1747.ep12277286
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12277286&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Rubinstein, Nurit
AU - Klaus-Kovtun, Vera
T1 - Epidermolysis Bullosa Acquisita Antigen Is Synthesized by Both Human Keratinocytes and Human Dermal Fibroblasts.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/12//
VL - 85
IS - 6
M3 - Article
SP - 542
EP - 545
SN - 0022202X
AB - In order to determine the source of epidermolysis bullosa acquisita (EBA) antigen, we studied its synthesis by human keratinocytes and fibroblasts in culture. To identify the antigen, we used the sera of 5 patients with EBA. These sera had antibodies directed against the epidermal basement membrane zone (BMZ) at titers of 5-80. The 5 sera were further characterized by immunoblotting on extracts of the epidermal BMZ. In concert with previous reports, 4 sera stained a 290 kD polypeptide, 3 sera weakly stained a 145 kD polypeptide, and 1 serum did not bind either polypeptide. To study the synthesis of the ERA antigen, cultured human keratinocytes and fibroblasts, derived from neonatal foreskins, were metabolically labeled with 14C-labeled amino acids. Radiolabeled newly synthesized proteins that were extracted from these cultures with nonionic detergent were used in an immunoprecipitation assay. The precipitated proteins were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography. All 5 EBA sera, but none of 3 bullous pemphigoid or 4 normal human sera, precipitated a 290 kD polypeptide from extracts of both keratinocytes and fibroblasts. Approximately equal amounts of this 290 kD polypeptide were precipitated from equivalent amounts of extracts from either cell type. The 290 kD polypeptide was also specifically precipitated by ERA sera from extracts of a human squamous cell carcinoma line, SCC-15. The 145 kD polypeptide was not detected in the newly synthesized proteins of any of these cell cultures. This finding suggests that the 145 kD polypeptide is not a precursor of the 290 kD polypeptide. Taken together these results demonstrate that the EBA antigen is synthesized by both human keratinocytes and fibroblasts, and is not a tissue (epidermal)-specific product. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMOLYSIS bullosa
KW - ANTIGENS
KW - KERATINOCYTES
KW - FIBROBLASTS
KW - BASAL lamina
KW - AMINO acids
KW - POLYACRYLAMIDE gel electrophoresis
N1 - Accession Number: 12277377; Stanley, John R. 1 Rubinstein, Nurit 1 Klaus-Kovtun, Vera 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p542; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: BASAL lamina; Subject Term: AMINO acids; Subject Term: POLYACRYLAMIDE gel electrophoresis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277377
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cooper, Kevin D.
AU - Breathnach, Stephen M.
AU - Caughman, S. Wright
AU - Palini, Alessio G.
AU - Waxdal, Myron J.
AU - Katz, Stephen I.
T1 - Fluorescence Microscopic and Flow Cytometric Analysis of Bone Marrow-Derived Cells in Human Epidermis: A Search for the Human Analogue of the Murine Dendritic Thy-1+ Epidermal Cell.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/12//
VL - 85
IS - 6
M3 - Article
SP - 546
EP - 552
SN - 0022202X
AB - Lymphoid cells with an affinity for the epidermis (epidermotropic lymphocytes) have been proposed to play a role in the immune functions of the epidermis. However, antigen-presenting Langerhans cells (LC) and indeterminate cells are presently the only cells in the human epidermis which have been demonstrated to originate in the bone marrow. Recent studies of murine epidermis have identified a population of bone marrow-derived cells which express Thy-1 antigen and which are present in a similar density to, but distinct from, LC. We therefore sought to identify the potential human analogue of the murine Thy-1+ epidermal cell utilizing a battery of antileukocyte reagents in immunohistochemical flow cytometric, and cell sorting studies. A panel of antibodies failed to detect significant numbers of human Thy-1 antigen-bearing cells, T cells, B cells, monocytes/macrophages (other than LC), and natural killer cells in tissue sections, epidermal sheets, and epidermal cell (EC) suspensions. This was the case using EC suspensions either unfractionated or fractionated on Ficoll-Hypaque to enrich for leukocyte subpopulations. Since the nature of the murine Thy-1+ EC is uncertain, it is possible that antibodies directed against well-defined leukoeyte suhpopulations may not be of value in the detection of a potential human analogue. We therefore utilized double fluorescence staining with anti-HLe-1, an antibody which Identifies all human leukocytes, and anti-HLA-Dr (Dr), which identifies epidermal LC, in order to demonstrate a potential population of HLe-1+ Dr- non-LC, bone marrow-derived cells. The vast majority of HLe-1+ cells were HLA-Dr+ LC; these were present at a density of 608 cells/mm2 in epidermal sheets. A minor population of HLe-1+ cells which did not express HLA-Dr (HLe-1+ Dr-) was observed in tissue sections, epidermal sheets, and EC suspensions. The nondendritic morphology and low density of these HLe-1+ Dr- EC in epidermal sheets (mean density of 4.2 ± 1.6 cells/mm2) precluded their representing a strict human analogue of the murine Thy-1+ EC, since murine Thy-1+ EC are dendritic and are present in a density similar to that of LC. Purified preparations of the minor HLe-1+ Dr- EC population obtained by electronic cell sorting or panning and examined ultrastructurally were not enriched for any bone marrow-derived cell population. Thus, using currently available markers and sorting technology, we have been unable to identify a human analogue of the murine dendritic Thy-1+ epidermal cell. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE marrow
KW - LYMPHOCYTES
KW - FLUORESCENCE
KW - FLOW cytometry
KW - LANGERHANS cells
KW - KILLER cells
KW - IMMUNOHISTOCHEMISTRY
N1 - Accession Number: 12277391; Cooper, Kevin D. 1 Breathnach, Stephen M. 2 Caughman, S. Wright 3 Palini, Alessio G. 4 Waxdal, Myron J. 4 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A 2: Charing Cross and Westminster Hospital Medical School, The Reynold's Building, St. Dunstan's Road, Hammersmith, London W6 8RP, U.K. 3: Dermatology Research Labs, Room 5538, Kresge I, Box 56, Ann Arbor, Michigan 48109 4: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p546; Subject Term: BONE marrow; Subject Term: LYMPHOCYTES; Subject Term: FLUORESCENCE; Subject Term: FLOW cytometry; Subject Term: LANGERHANS cells; Subject Term: KILLER cells; Subject Term: IMMUNOHISTOCHEMISTRY; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277391
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12277391&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breathnach, Stephen M.
AU - Katz, Stephen I.
T1 - Effect of X-irradiation on Epidermal Immune Function: Decreased Density and Alloantigen-Presenting Capacity of Ia+ Langerhans Cells and Impaired Production of Epidermal Cell-Derived Thymocyte Activating Factor (ETAF).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1985/12//
VL - 85
IS - 6
M3 - Article
SP - 553
EP - 558
SN - 0022202X
AB - The mechanisms involved in the modulation of cutaneous immune responses by UV radiation have been extensively investigated; by contrast, few studies have addressed the effects of x-irradiation on epidermal immune function. We therefore investigated the effect of x-irradiation of mice on: (a) the density of epidermal Ia+ Langerhans cells (LC) in immunofluorescence studies, (b) epidermal cell (EC) allostimulatory capacity in the allogeneic EC-lymphocyte reaction (ELR), and (c) production of epidermal cell-derived thymocyte activating factor (ETAF). C3H/He and BALB/c mice were irradiated with 900, 1,800, 2,700, or 3,600 rad from a 137Cs source, and sacrificed 10 h or 3 days later. X-irradiation of mice 10 h previously only slightly decreased the density of epidermal Ia+ LC and did not affect the capacity of their EC to stimulate allogeneic responder lymphocytes in the ELR. X-irradiation of mice 3 days previously, however, resulted in a dose-dependent decrease in the density of Ia+ LC. This decrease was accompanied by a substantial reduction in EC allostimulatory capacity in the ELR at all doses of x-irradiation. ETAF production by cultured EC from mice x-irradiated 3 days previously was also found to be diminished at all doses of x-irradiation. Trypan blue exclusion studies demonstrated that the observed decreases in EC allostimulatory capacity and ETAF production were not the result of a generalized lethal effect of x-irradiation on EC. The reduction in EC allostimulatory capacity following in vivo x-irradiation could not be reversed by addition of exogenous ETAF or interleukin-1 in the ELR. Taken together, these results indicate that x-irradiation decreases the density of Ia+ LC, impairs LC alloantigen-presenting function, and reduces ETAF production. Thus cutaneous x-irradiation may affect inflammatory and neoplastic processes not only by its antimitotic activity, but also by a direct effect on EC which subserve immunologic functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - ULTRAVIOLET radiation
KW - LANGERHANS cells
KW - X-rays -- Therapeutic use
KW - IMMUNOFLUORESCENCE
KW - INTERLEUKIN-1
N1 - Accession Number: 12277399; Breathnach, Stephen M. 1 Katz, Stephen I. 2; Affiliation: 1: Department of Medicine (Dermatology), Charing Cross and Westminster Medical School, Charing Cross Hospital, Fulham Palace Road, London WG 8RF, U.K. 2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec85, Vol. 85 Issue 6, p553; Subject Term: IMMUNE response; Subject Term: ULTRAVIOLET radiation; Subject Term: LANGERHANS cells; Subject Term: X-rays -- Therapeutic use; Subject Term: IMMUNOFLUORESCENCE; Subject Term: INTERLEUKIN-1; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277399
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12277399&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shapiro, M. B.
AU - Schein, S. J.
AU - de Monasterio, F. M.
T1 - Regularity and Structure of the Spatial Pattern of Blue Cones of Macaque Retina.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/12//
VL - 80
IS - 392
M3 - Article
SP - 803
SN - 01621459
AB - Models were developed for describing the regular pattern of blue cones in macaque retina. Two functional descriptions were applied to patterns, one based on the cdf of interpoint distances, the other on the cdf of the central angles of Voronoi regions. Disordered triangular and square lattices and hard balls failed to model the blue-cone point pattern. An elastic-ball model was developed whose spatial properties fit well those of the blue-cone pattern. This model employed a hard core and a soft surrounding shell and is proposed as a valid model for the blue-cone pattern. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATTICE theory
KW - LIGHT cones
KW - MACAQUES
KW - RETINA
KW - VORONOI polygons
KW - POSTERIOR segment (Eye)
KW - PARTICLES (Nuclear physics)
KW - POLYGONS
KW - Ball model.
KW - Disorder
KW - Lattice structure
KW - Modeling
KW - Spatial statistics
N1 - Accession Number: 4610361; Shapiro, M. B. 1; Schein, S. J. 2; de Monasterio, F. M. 2; Affiliations: 1: Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20892.; 2: Section on Visual Processing, Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.; Issue Info: Dec85, Vol. 80 Issue 392, p803; Subject Term: LATTICE theory; Subject Term: LIGHT cones; Subject Term: MACAQUES; Subject Term: RETINA; Subject Term: VORONOI polygons; Subject Term: POSTERIOR segment (Eye); Subject Term: PARTICLES (Nuclear physics); Subject Term: POLYGONS; Author-Supplied Keyword: Ball model.; Author-Supplied Keyword: Disorder; Author-Supplied Keyword: Lattice structure; Author-Supplied Keyword: Modeling; Author-Supplied Keyword: Spatial statistics; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4610361&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Campbell, Gregory
AU - Skillings, John H.
T1 - Nonparametric Stepwise Multiple Comparison Procedures.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1985/12//
VL - 80
IS - 392
M3 - Article
SP - 998
SN - 01621459
AB - Nonparametric multiple comparisons are discussed, with particular emphasis given to stepwise procedures. Nonparametric analogs of the stepwise all-subset procedure of Einot and Gabriel are presented, along with an ad hoc nonparametric analog of the Newman-Keuls procedure. These new procedures are compared among themselves and with nonstepwise procedures based on Type I error levels and comparisonwise power. It is shown that these stepwise nonparametric procedures control Type I error levels, and that they have superior pairwise power compared to the commonly used nonstepwise procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERROR analysis (Mathematics)
KW - NONPARAMETRIC statistics
KW - MONTE Carlo method
KW - STATISTICS
KW - MATHEMATICAL statistics
KW - SET theory
KW - SIMULTANEOUS equations
KW - NUMERICAL analysis
KW - Experimentwise error rate
KW - Monte Carlo.
KW - Newman-Keuls
KW - Simultaneous test procedure
KW - Stepwise all-subset procedures
N1 - Accession Number: 4612552; Campbell, Gregory 1; Skillings, John H. 2; Affiliations: 1: Senior Staff Fellow, Laboratory of Statistical and Mathematical Methodology, Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20205.; 2: Professor, Department of Mathematics and Statistics, Miami University, Oxford, OH 45056.; Issue Info: Dec85, Vol. 80 Issue 392, p998; Thesaurus Term: ERROR analysis (Mathematics); Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: MONTE Carlo method; Thesaurus Term: STATISTICS; Thesaurus Term: MATHEMATICAL statistics; Subject Term: SET theory; Subject Term: SIMULTANEOUS equations; Subject Term: NUMERICAL analysis; Author-Supplied Keyword: Experimentwise error rate; Author-Supplied Keyword: Monte Carlo.; Author-Supplied Keyword: Newman-Keuls; Author-Supplied Keyword: Simultaneous test procedure; Author-Supplied Keyword: Stepwise all-subset procedures; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - Gen
ID - 9999-07197-000
AN - 9999-07197-000
AU - Trickett, Penelope K.
AU - Kuczynski, Leon
T1 - Parent Daily Report
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1986///
AD - Trickett, Penelope K., University of Southern California, Los Angeles, California, United States, 90089-0411
AV - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1 - Accession Number: 9999-07197-000. Partial author list: First Author & Affiliation: Trickett, Penelope K.; National Institute of Mental Health, Bethesda, Maryland, United States. Release Date: 20111212. Correction Date: 20160808. Test Format: Parents record 4 types of data following situations in which they used discipline with a misbehaving child: 'What my child did,' 'What I did,' 'What happened next,' and 'How I felt afterward.'. Language: English. Constructs: Parental Discipline Strategies; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Parent Daily Report is to allow parents to record specific details about disciplinary actions that they use with a misbehaving child.
AB - Description: The Parent Daily Report (Trickett & Kuczynski, 1986) was created in a study investigating child misbehaviors and parental discipline. Participants were 20 abusive families with children between the ages of 4 and 10. A matched control group of 20 families also participated. This instrument consists of a page of instructions, a page of examples, and the forms on which the parent is to record. Parents are asked to think about the times they used discipline during the day, and to write about at least three of them. They are to write exactly what the child did that required discipline, exactly what they said and did in the situation, how the situation turned out for both the parent and the child, and how they felt about the situation. These instructions were followed by a list of 'common child misbehaviors' such as fighting with others and whining. Parents were instructed to record their observations for 5 consecutive days. The transcripts of discipline episodes were coded by a rater blind to group membership in terms of type of child misbehavior, type of parental discipline, nature of child's compliance or noncompliance to the parental intervention, and nature of parent affective response to the situation. For the purposes of estimating intercoder reliability, transcripts of 22 parents were independently recoded. The percentage of agreement between the two independent coders ranged from 80% for the child compliance categories to 94% for parental affective response. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Children's Misbehaviors
KW - Parent Daily Report
KW - Parental Discipline Strategies
KW - Psychometric Properties
KW - Test Development
U5 - Parent Daily Report [Test Development]Children's misbehaviors and parental discipline strategies in abusive and nonabusive families. (AN: 1986-12115-001 from PsycINFO) Trickett, Penelope K.; Kuczynski, Leon; Jan, 1986. Source: Developmental Psychology. 22(1), American Psychological Association, US; Jan, 1986; Administration: Paper Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs), School Age (6-12 yrs); Population: Human; Male; Female; Location: United States; Sample: Families with a Child between the Ages of 4 and 11 Keywords: Children's Misbehaviors; Parent Daily Report; Parental Discipline Strategies; Psychometric Properties; Test Development; Subjects: Behavior Problems; Child Discipline; Coercion; Daily Activities; Parenting; Self-Report; Test Construction;
DO - 10.1037/t07197-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07197-000&site=ehost-live&scope=site
UR - pennyt@usc.edu
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-07777-000
AN - 9999-07777-000
AU - Whitehead, William E.
AU - Busch, Catherine M.
AU - Heller, Barbara R.
AU - Costa, Paul T. Jr.
T1 - Menstrual History Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1986///
AD - Whitehead, William E.
AV - Commercial: No; Permissions: Contact Publisher; Fee: Unknown. Test Items: No
N1 - Accession Number: 9999-07777-000. Partial author list: First Author & Affiliation: Whitehead, William E.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. Release Date: 20120109. Instrument Type: Inventory/Questionnaire. Test Format: For each item, the response possibilities were Never; Rarely, once or twice a year, if symptoms were severe; Sometimes, 3 to 6 times per year, if symptoms were worse than usual; and Often, more than 6 times per year.. Language: English. Constructs: Menstrual Symptoms; Modeling of Illness Behavior; Classification: Physical Health/Illness Related Assessment (7300); Family Relationships and Parenting (6100). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Menstrual History Questionnaire is to assess behaviors of mothers that influence menstrual symptoms and illness behavior in daughters.
AB - Description: The Menstrual History Questionnaire (Whitehead et al., 1986) assesses parent behaviors that encouraged adoption of the sick role in women. Four questions were available from a previous survey that discriminated between people who made multiple somatic complaints from people who made few (Whitehead et al., 1982). Using these questions as models, a new set of eight items describing parental responses to menstrual symptoms and four items describing maternal modeling of the menstrual sick role were written. The items on cold symptoms were retained, making three subscales. Two versions of this questionnaire were developed—one to be completed by a nursing student sample and the other to be completed independently by their mothers. Modeling of sick role behavior for nonmenstrual symptoms during childhood was assessed by an open-ended question as to whether any member of the immediate family had a chronic illness before the respondent was 15 years of age. The Menstrual History Questionnaire also asked subjects (a) to identify the frequency of absences from school or work due to illness during the preceding year, (b) to list the illnesses for which they sought medical treatment in the past year, and (c) to identify menstrual and gynecological disorders since age 15 for which medical treatment was sought. A principal components analysis of the daughters' responses to the social learning items resulted in four components with eigenvalues greater than 1. Varimax rotation resulted in three components interpreted to represent the three social learning scales—encouragement of sick role behaviors for menstrual symptoms (six items), encouragement of sick role behaviors for cold symptoms (four items), and modeling of the menstrual sick role (four items). The fourth component consisted of only two items and was not used for further analyses. Using the daughters' responses, the alpha reliabilities for the three scales were .81, .79, and .82, respectively. Results for the mothers' responses were similar. The agreement between mothers and their daughters was estimated by computing the correlation between scores on the subscales. This provided a measure of convergent validity. (PsycTESTS Database Record (c) 2014 APA, all rights reserved)
KW - Menstrual History Questionnaire
KW - Sick Role Behaviors
KW - Social Learning Influences
KW - Test Development
KW - Psychometric Properties
U5 - Menstrual History Questionnaire [Test Development]Social learning influences on menstrual symptoms and illness behavior. (AN: 1987-21629-001 from PsycINFO) Whitehead, William E.; Busch, Catherine M.; Heller, Barbara R.; Costa, Paul T.; 1986. Source: Health Psychology. 5(1), Lawrence Erlbaum Associates, US; 1986; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs); Population: Human; Female; Sample: Daughters and Mothers Aged 18 to 39 Keywords: Menstrual History Questionnaire; Sick Role Behaviors; Social Learning Influences; Test Development; Psychometric Properties; Subjects: Family History; Illness Behavior; Menstruation; Mother Child Relations; Questionnaires; Social Influences; Social Learning; Test Construction;
DO - 10.1037/t07777-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07777-000&site=ehost-live&scope=site
UR - william_whitehead@med.unc.edu
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-14586-000
AN - 9999-14586-000
AU - Berg, Carol J.
AU - Rapoport, Judith L.
AU - Flament, Martine
T1 - Leyton Obsessional Inventory Survey—Child Version
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1986///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-14586-000. Acronyms: LOI-C. Partial author list: First Author & Affiliation: Berg, Carol J.; National Institute of Mental Health, Child Psychiatry Branch, Bethesda, Maryland, United States. Release Date: 20120910. Correction Date: 20151109. Instrument Type: Survey. Test Format: In the Leyton Obsessional Inventory Survey—Child Version if the respondent indicates 'yes' to an item, they then rate that item on a 4-point scale.. Language: English. Constructs: Obsessive Compulsive Disorder; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Female (40); Male (30). Age Group: Adolescence (13-17 yrs) (200); Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Other Versions: 9999-33581-000, Leyton Obsessional Inventory—Child Chinese Version, Translation.
N2 - Administration Method: Paper
AB - Purpose: The Leyton Obsessional Inventory Survey—Child Version differentiates obsessive child patients from normal controls on total scores for obsessional symptoms as well as total scores for degree of resistance to the symptoms and interference with everyday life.
AB - Description: The Leyton Obsessional Inventory Survey—Child Version (LOI-CV; Berg, Rapoport, & Flament, 1986) consists of 44, or 20 items that are designed to distinguish adolescents with Obsessional-Compulsive Disorder (OCD) from both psychiatric patients as well as from normal controls. The 20-item version demonstrated high internal reliability with Cronbach's alpha of 0.81. Pearson product moment correlations for 'yes' and total obsessive responses (TO) for the entire goup, males, and females, were r = 0.88-0.89 and for interference and TO responses, r = 0.95 to 0.96, demonstrating that the TO scores are interchangeable with 'yes' and interference scores for factor analyses. Four factors accounted for 47% of the variance in the principal components factor analysis: 1. general obsessive, 2. dirt-contamination, 3. numbers-luck, and 4. school. In the 44-item version, obsessive patients showed higher resistance scores and a trend for higher interference scores from psychiatric controls. Correlations between 'yes' scores with resistance and interference for all groups gave coefficients of r = 0.83, 0.86 while resistance and interference were r = 0.86. The correlations for the individuals groups ranged from r = 0.73 to 0.88. Correlations of the LOI-CV scores and scores of Obsessive Compulsive Rating Scale (OCR), Comprehensive Psychopathological Rating Scale (CPRS-OC), and NIMH Obsessive Compulsive Scale (NIMH-OC) were r = 0.77 to 0.89, and NIMH Global Scale (NIMH-G) were r = 0.69 to 0.77. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Leyton Obsessional Inventory Survey—Child Version
KW - Obsessive Compulsive Disorder
KW - Obsessions
KW - Screening Tests
KW - Test Development
KW - Internal Consistency
KW - Test Reliability
KW - Test Validity
KW - Disgust Sensitivity
KW - Psychopathological Symptoms
U5 - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Development]The survey form of the Leyton Obsessional Inventory—Child Version: Norms from an epidemiological study. (AN: 1989-21065-001 from PsycINFO) Berg, Carol Z.; Whitaker, Agnes; Davies, Mark; Flament, Martine F.; Rapoport, Judith L.; Nov, 1988. Source: Journal of the American Academy of Child & Adolescent Psychiatry. 27(6), Lippincott Williams & Wilkins, US; Nov, 1988; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Female; Male; Sample: 9th through 12th Grade Students; Location: United States Keywords: Leyton Obsessional Inventory Survey—Child Version; Obsessive Compulsive Disorder; Obsessions; Screening Tests; Test Development; Internal Consistency; Subjects: Obsessions; Obsessive Compulsive Disorder; Screening Tests; Test Construction; Test Reliability;
U5 - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Development]The Leyton Obsessional Inventory—Child Version. (AN: 1987-02850-001 from PsycINFO) Berg, Carol J.; Rapoport, Judith L.; Flament, Martine; Jan, 1986. Source: Journal of the American Academy of Child Psychiatry. 25(1), Lippincott Williams & Wilkins, US; Jan, 1986; Administration: Paper Age Group: Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: Adolescent Obsessive-Compulsive Disorder Patients Keywords: Leyton Obsessional Inventory Survey—Child Version; Obsessive Compulsive Disorder; Obsessions; Screening Tests; Test Development; Test Reliability; Test Validity; Subjects: Child Psychology; Obsessions; Obsessive Compulsive Disorder; Screening Tests; Test Construction; Test Reliability; Test Validity;
U5 - Leyton Obsessional Inventory Survey—Child Version (LOI-C) [Test Use]Disgust sensitivity and psychopathological symptoms in non-clinical children. (AN: 2008-04005-003 from PsycINFO) Muris, Peter; van der Heiden, Simone; Rassin, Eric; Jun, 2008. Source: Journal of Behavior Therapy and Experimental Psychiatry. 39(2), Elsevier Science, Netherlands; Jun, 2008; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs), Adolescence (13-17 yrs); Population: Human; Male; Female; Sample: Primary School Children (9-13 Years Old) Keywords: Leyton Obsessional Inventory Survey—Child Version; Disgust Sensitivity; Psychopathological Symptoms; Subjects: Child Psychopathology; Emotions; Obsessions; Obsessive Compulsive Personality Disorder;
DO - 10.1037/t14586-000
L3 - Full; Full text; 999914586_full_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-14586-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-07472-000
AN - 9999-07472-000
AU - Bernstein, Eve M.
AU - Putnam, Frank W.
T1 - Dissociative Experiences Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1986///
AD - Bernstein, Eve M.
AV - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1 - Accession Number: 9999-07472-000. Acronyms: DES. Partial author list: First Author & Affiliation: Bernstein, Eve M.; American University, Department of Psychology, Washington, District of Columbia, United States. Release Date: 20130107. Correction Date: 20150608. Instrument Type: Rating Scale. Test Format: Respondents make slashes on 100-mm lines to indicate where they fall on a continuum for each question.. Language: English. Constructs: Dissociation; Classification: Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Other Versions: 9999-40219-000, Dissociative Experiences Scale—Arabic Version, Translation.
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Dissociative Experiences Scale is to measure dissociation in normal and clinical populations.
AB - Description: The Dissociative Experiences Scale (DES; Bernstein & Putnam, 1986) was developed to offer a means of reliably measuring dissociation in normal and clinical populations. Scale items were developed using clinical data and interviews, scales involving memory loss, and consultations with experts in dissociation. Pilot testing was performed to refine the wording and format of the scale. The scale is a 28-item self-report questionnaire. Subjects were asked to make slashes on 100-mm lines to indicate where they fall on a continuum for each question. In addition, demographic information (age, sex, occupation, and level of education) was collected so that the connection between these variables and scale scores could be examined. The mean of all item scores ranges from 0 to 100 and is called the DES score. The scale was administered to between 10 and 39 subjects in each of the following populations: normal adults, late adolescent college students, and persons suffering from alcoholism, agoraphobia, phobicanxious disorders, posttraumatic stress disorder, schizophrenia, and multiple personality disorder. Reliability testing of the scale showed that the scale had good test-retest and good split-half reliability. Item-scale score correlations were all significant, indicating good internal consistency and construct validity. A Kruskal-Wallis test and post hoc comparisons of the scores of the eight populations provided evidence of the scale's criterion-referenced validity. The scale was able to distinguish between subjects with a dissociative disorder (multiple personality) and all other subjects. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Dissociative Experiences Scale
KW - Psychological Assessment
KW - Test Development
KW - Test Reliability
KW - Test Validity
KW - Factor Structure
KW - Dissociative Pathology
KW - Dissociation
U5 - Dissociative Experiences Scale (DES) [Test Development]Development, reliability, and validity of a dissociation scale. (AN: 1987-14407-001 from PsycINFO) Bernstein, Eve M.; Putnam, Frank W.; Dec, 1986. Source: Journal of Nervous and Mental Disease. 174(12), Lippincott Williams & Wilkins, US; Dec, 1986; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs); Population: Human; Male; Female; Sample: Late Adolescent College Students Keywords: Dissociative Experiences Scale; Psychological Assessment; Test Development; Test Reliability; Test Validity; Subjects: Dissociation; Dissociative Disorders; Psychological Assessment; Test Construction; Test Reliability; Test Validity;
U5 - Dissociative Experiences Scale (DES) [Test Review]Confirmatory factor analysis of single- and multiple-factor competing models of the Dissociative Experiences Scale in a nonclinical sample. (AN: 2002-01707-010 from PsycINFO) Stockdale, Gary D.; Gridley, Betty E.; Balogh, Deborah Ware; Holtgraves, Thomas; Mar, 2002. Source: Assessment. 9(1), Sage Publications, US; Mar, 2002; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: University Students Keywords: Dissociative Experiences Scale; Factor Structure; Dissociative Pathology; Dissociation; Subjects: Dissociative Disorders; Experiences (Events); Factor Structure; Psychopathology; Screening Tests; Test Validity;
DO - 10.1037/t07472-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-07472-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-29427-000
AN - 9999-29427-000
AU - Levine, Jerome
AU - Schooler, Nina R.
T1 - Systematic Assessment for Treatment Emergent Events−Specific Inquiry
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1986///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1 - Accession Number: 9999-29427-000. Acronyms: SAFTEE-SI. Partial author list: First Author & Affiliation: Levine, Jerome; University of Maryland, Department of Psychiatry, Baltimore, Maryland, United States. Release Date: 20170109. Test Format: The SAFTEE-SI comprises 78 items and consists of standardized, structured interview questions, checklists, and a five-point Likert-type scale ranging from 1 (none/minimal) to 5 (very severe).. Language: English. Constructs: Treatment Emergent Events; Treatment Side Effects; Classification: Treatment, Rehabilitation, and Therapeutic Processes (7900). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Interview
AB - Purpose: The Systematic Assessment for Treatment Emergent Events−Specific Inquiry is designed to assess side effects that emerge during clinical trials.
AB - Description: The Systematic Assessment for Treatment Emergent Events−Specific Inquiry (SAFTEE-SI; Levine & Schooler, 1986) was developed in an effort to improve the precision with which side effects are assessed during clinical trials. The SAFTEE-SI is one of two versions; the other is the Systematic Assessment for Treatment Emergent Events−General Inquiry (SAFTEE-GI; Levine & Schooler, 1986). The SAFTEE-GI is designed to be a global measure, while the SAFTEE-SI is more detailed. The GI is an open-ended inquiry about 'any physical or health problems experienced during the past week.' The SI includes the administration of the GI, which is always asked first. The SI then presents questions in 23 categories, with two or more specific questions in each, for a total of 78 questions. The SAFTEE categories are organized more or less by organ system or body part (head, eyes/vision, ears/hearing, mouth, chest, heart, stomach, etc.). The last few categories concern sleeping, memory, concentration, and mood. This systematic and specific inquiry about all body parts and organ systems avoids the pitfall of the investigator having to know in advance what side effects to expect. The questions are standardized and presented in the precise form they are to be asked of the patient. In addition, raters are asked to choose from a list of 76 'preferred event terms' to record reported events rather than their own term or the patient's words. The SAFTEE-SI also captures information regarding the onset, duration, pattern, severity, attribution of cause, and action taken by the clinician in response to the event. Collection of this information is facilitated with precoded responses to each category of information and a series of suggested probe questions. There is also space for 'study specific' inquiries to be written in and for responses to be recorded. The SI takes 15−20 minutes to administer. No psychometric data regarding the development of the SAFTEE-SI are reported in the Levine & Schooler (1986) development citation, nor in a comparison of the SI and GI forms reported by Rabkin et al., (1992). (PsycTESTS Database Record (c) 2017 APA, all rights reserved)
KW - Adverse Health Events
KW - Attribution of Cause
KW - Checklist
KW - Clinical Events
KW - Duration
KW - Even Severity
KW - Event Content
KW - Event Type
KW - Form Comparison
KW - General Inquiry Form
KW - Medication Side Effects
KW - SAFTEE-SI
KW - SAFTEE-GI
KW - Severity
KW - Systematic Assessment for Treatment Emergent Events−Specific Inquiry
KW - Systematic Inquiry Form
U5 - Systematic Assessment for Treatment Emergent Events−Specific Inquiry (SAFTEE-SI) [Test Review]General versus systematic inquiry about emergent clinical events with SAFTEE: Implications for clinical research. (AN: 1992-28452-001 from PsycINFO) Rabkin, Judith G.; Markowitz, Jeffrey S.; Ocepek-Welikson, Katje; Wager, Steven S.; Feb, 1992. Source: Journal of Clinical Psychopharmacology. 12(1), Lippincott Williams & Wilkins, US; Feb, 1992; Administration: Interview Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Samples: Patients Treated with Imipramine, Phenelzine, Or Placebo in Clinical Trials Keywords: Adverse Health Events; Attribution of Cause; Checklist; Clinical Events; Duration; Even Severity; Event Content; Event Type; Form Comparison; General Inquiry Form; Medication Side Effects; SAFTEE-SI; SAFTEE-GI; Severity; Systematic Assessment for Treatment Emergent Events−Specific Inquiry; Systematic Inquiry Form; Subjects: Checklist (Testing); Clinical Trials; Drug Therapy; Evaluation; Imipramine; Patient Safety; Phenelzine; Placebo; Side Effects (Drug); Structured Clinical Interview; Test Forms;
DO - 10.1037/t29427-000
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Wetzel, M.G.
T1 - Progress in Retinal Research (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1986/01//Jan/Feb86
VL - 74
IS - 1
M3 - Book Review
SP - 92
EP - 92
SN - 00030996
AB - Reviews the book 'Progress in Retinal Research,' edited by Neville N. Osborne and Gerald J. Chandler.
KW - Retina
KW - Nonfiction
KW - Progress in Retinal Research (Book)
N1 - Accession Number: 11232292; Wetzel, M.G. 1; Affiliations: 1: National Eye Institute, National Institutes of Health; Issue Info: Jan/Feb86, Vol. 74 Issue 1, p92; Subject Term: Retina; Subject Term: Nonfiction; Reviews & Products: Progress in Retinal Research (Book); Number of Pages: 1/4p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Santos, Eugenio
T1 - ONCOGENE RESEARCH.
JO - BioScience
JF - BioScience
Y1 - 1986/01//
VL - 36
IS - 1
M3 - Book Review
SP - 55
EP - 56
SN - 00063568
AB - Reviews the book "Genes and Cancer," by Alan R. Liss, edited by J. Michael Bishop, Janet D. Rowley, and Mel Greaves.
KW - Cancer genetics
KW - Nonfiction
KW - Liss, Alan
KW - Genes & Cancer (Book)
N1 - Accession Number: 10094813; Santos, Eugenio 1; Affiliations: 1: Frederick Cancer Research Facility, National Cancer Institute, P.O. Box B, Frederick, MD 21701; Issue Info: Jan1986, Vol. 36 Issue 1, p55; Subject Term: Cancer genetics; Subject Term: Nonfiction; Reviews & Products: Genes & Cancer (Book); People: Liss, Alan; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 950
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brown, J.
AU - Whittle, H. C.
AU - Berzins, K.
AU - Howard, R. J.
AU - Marsh, K.
AU - K. Sjoberg
T1 - Inhibition of Plasmodium falciparum growth by IgG antibody produced by human lymphocytes transformed with Epstein-Barr virus.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1986/01//
VL - 63
IS - 1
M3 - Article
SP - 135
EP - 140
PB - Wiley-Blackwell
SN - 00099104
AB - Supernatants from Epstein-Barr virus (EBV)-stimulated B lymphocytes obtained from two adult Gambians who were partially immune to malaria markedly inhibited the growth of Plasmodium falciparum in vitro (55-95% inhibition). When 22 separate colonies were derived by micromanipulation from one of these primary cultures and their supernatants assayed, the degree of inhibition correlated with levels of IgG fluorescent antibody and total IgG. The inhibitory anti-P. falciparum IgG immunoprecipitated an antigen of mol. wt 195,000, identified as the major schizont surface glycoprotein by dual biosynthetic labelling with 3H-glucosamine or -35S-methionine. Other studies on the analogous schizont surface protein of rodent malarias have shown that this antigen stimulates protective immunity. Production of this inhibitory antibody by adult Gambians may therefore contribute to their immunity to malaria. Human antibodies produced by EBV-stimulated B lymphocytes may be used to identify other important P. falciparum antigens and have potential applications for immunotherapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA
KW - IMMUNOGLOBULIN G
KW - PLASMODIUM falciparum
KW - PROTOZOAN diseases
KW - IMMUNOGLOBULINS
KW - GLUCOSAMINE
KW - MICRURGY
KW - B lymphocyte culture supernatants growth inhibition
KW - Epstein-Barr virus
KW - falciparum malaria
N1 - Accession Number: 16003925; Brown, J. 1 Whittle, H. C. 1 Berzins, K. 2,3 Howard, R. J. 2,3 Marsh, K. 1 K. Sjoberg 2,3; Affiliation: 1: Medical Research Council Laboratories, Fajara, The Gambia, West Africa. 2: Department of Immunology, Wenner Gren Institute, University of Stockholm, Sweden 3: Malaria Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jan1986, Vol. 63 Issue 1, p135; Subject Term: MALARIA; Subject Term: IMMUNOGLOBULIN G; Subject Term: PLASMODIUM falciparum; Subject Term: PROTOZOAN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: GLUCOSAMINE; Subject Term: MICRURGY; Author-Supplied Keyword: B lymphocyte culture supernatants growth inhibition; Author-Supplied Keyword: Epstein-Barr virus; Author-Supplied Keyword: falciparum malaria; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Smalley, R. V.;
AU - Oldham, R. K.;
T1 - Phase I trials of biological response modifiers
CT - Phase I trials of biological response modifiers
JO - Drugs under Experimental and Clinical Research (Switzerland)
JF - Drugs under Experimental and Clinical Research (Switzerland)
Y1 - 1986/01/01/
VL - 12
IS - Feb
SP - 31
EP - 39
SN - 03786501
AD - Biological Response Modifiers Program, Frederick Cancer Res. Facility, National Cancer Institute, Frederick, MD 21701
N1 - Accession Number: 24-06780; Language: English; References: 32; Journal Coden: DECRDP; Section Heading: Methodology; Drug Evaluations; Abstract Author: D. L. Thompson
N2 - The methodology of clinical trials evaluating biological response modifiers, e.g., interferons, monoclonal antibodies, and immunoconjugates, was discussed.
KW - Interferons--clinical studies--methodology;
KW - Antibodies--monoclonal--clinical studies, methodology;
KW - Immunoconjugates--clinical studies--methodology;
KW - Methodology--clinical studies--biological response modifiers;
KW - Clinical studies--methodology--biological response modifiers;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lew, A. M.
AU - Lillehoj, E. P.
AU - Cowan, E. P.
AU - Maloy, W. L.
AU - Van Schravendijk, M. R.
AU - Coligan, J. E.
T1 - Class I genes and molecules: an update.
JO - Immunology
JF - Immunology
Y1 - 1986/01//
VL - 57
IS - 1
M3 - Article
SP - 3
EP - 18
PB - Wiley-Blackwell
SN - 00192805
AB - The article presents information on class I genes and molecules. Class I molecules of the major histocompatibility complex were the first molecules identified as targets for the rejection of tissue grafts. Since this initial observation, extensive studies have produced considerable insight into the structure and function of this highly diverse family of molecules. The remarkable hallmark of the class I family is its unparalleled degree of genetic polymorphism and diversity. The polymorphism is reflected by the fact that multiple loci encode class I molecules, and for each locus there can be upwards of 100 alleles. The purpose of this article is to assimilate the information accumulated on the class I molecules since previous reviews.
KW - GENETIC polymorphisms
KW - GENES
KW - MOLECULES
KW - IMMUNITY
KW - IMMUNOLOGY
KW - POPULATION genetics
N1 - Accession Number: 14004172; Lew, A. M. 1 Lillehoj, E. P. 1 Cowan, E. P. 1 Maloy, W. L. 1 Van Schravendijk, M. R. 2 Coligan, J. E. 1; Affiliation: 1: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Tropical Medicine Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford U.K.; Source Info: Jan1986, Vol. 57 Issue 1, p3; Subject Term: GENETIC polymorphisms; Subject Term: GENES; Subject Term: MOLECULES; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: POPULATION genetics; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WEINGARTNER, HERBERT
T1 - THE ROOTS OF FAILURE.
JO - Psychology Today
JF - Psychology Today
Y1 - 1986/01//
VL - 20
IS - 1
M3 - Article
SP - 6
EP - 7
SN - 00333107
AB - The article cites a research study regarding the aspects of memory failure conducted by the U.S. National Institutes of Health. Its describes the aim of study to establish a relationship between brain function changes and memory failure by comparison of various memory disorders, impact of drugs for changing cognitive processes, and role of drugs for reducing memory failure. It concludes that drugs effective in increasing brain peptides are to be further tested on their ability to enhance memory.
KW - MEMORY -- Research
KW - BRAIN abnormalities
KW - DRUGS -- Effectiveness
KW - PEPTIDES
KW - UNITED States
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 52929841; WEINGARTNER, HERBERT 1; Affiliation: 1: Chief of Laboratory, Cognition and Human Performance, National Institute on Drug Abuse, Baltimore, Md.; Source Info: Jan86, Vol. 20 Issue 1, p6; Subject Term: MEMORY -- Research; Subject Term: BRAIN abnormalities; Subject Term: DRUGS -- Effectiveness; Subject Term: PEPTIDES; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kohn, Melvin L.
AU - Slomeznski, Kazimierz M.
AU - Schoenbach, Carrie
T1 - Social Stratification and the Transmission of Values in the Family: A Cross–National Assessment.
JO - Sociological Forum
JF - Sociological Forum
Y1 - 1986///Winter86
VL - 1
IS - 1
M3 - Article
SP - 73
PB - Wiley-Blackwell
SN - 08848971
AB - For both the U.S. and Poland, we develop measurement models of the family's social-stratification position and of parents' and children's valuations of self-direction. We find that the relationship between parents' and children's values is much stronger than past studies had indicated. In both countries the family's stratification position has an impressive bearing on the values of its adolescent and young-adult offspring. Much of this impact is through social stratification affecting parents values, and parents' values, in turn, affecting children's values. Social stratification affects parental values primarily because of the impact of parents' occupational self-direction on their values. Although parents' and children's values may he reciprocally related, the predominant effects are from parents' to children's values. The one notable cross-national difference we find is in the relative roles of fathers and mothers in the intergenerational transmission of values: in the United States, fathers play at least as important a role as do mothers; in Poland, mothers play the predominant role. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Forum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL stratification
KW - SOCIAL classes
KW - SOCIAL status
KW - SOCIAL structure
KW - UNITED States
KW - POLAND
KW - FAMILY RELATIONS AND COMMUNICATION
N1 - Accession Number: 10793684; Kohn, Melvin L. 1 Slomeznski, Kazimierz M. 2 Schoenbach, Carrie 3; Affiliation: 1: The Johns Hopkins University and National Institute of Mental Health. 2: University of Warsaw National Institute of Mental Health Carrie Schoenbach. 3: National Institute of Mental Health.; Source Info: Winter86, Vol. 1 Issue 1, p73; Subject Term: SOCIAL stratification; Subject Term: SOCIAL classes; Subject Term: SOCIAL status; Subject Term: SOCIAL structure; Subject Term: UNITED States; Subject Term: POLAND; Author-Supplied Keyword: FAMILY RELATIONS AND COMMUNICATION; Number of Pages: 30p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vijay, Inder K.
AU - Oka, Takami
T1 - Developmental regulation of glycosyltransferases involved in biosynthesis of asparagine-linked glycoproteins in mouse mammary gland.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/01/02/
VL - 154
IS - 1
M3 - Article
SP - 57
EP - 62
PB - Wiley-Blackwell
SN - 00142956
AB - Three glycosyltransferases, namely N-acetylglucosaminyl-1-phosphotransferase, mannosyltransferase and glucosyltransferase, involved in the biosynthesis of asparagines-linked glycoproteins in the mouse mammary gland, were identified by characterization of the products formed by these enzymes. The tissue capacities of the glycosyltransferases, measured as pmol product formed g tissue-1 min-1, increase during developmental cycle of the gland until, at late lactational stage, they reach more than 34, 14 and 60 times, respectively, the basal level found in the tissue of virgin animals. Among the three enzymes at late lactational stage the specific activities of glucosyltransferase and N-acetylglucosaminyl-1-phosphotransferase increase 7-fold and 4-fold respectively, whereas mannosyltransferase shows a mere 1.4-fold increase during tissue development. All of the enzymes, both in terms of tissue capacity and specific activity, return to the basal levels of the virgin gland one month after the end of lactation. The activities of the three enzymes in the lactating gland decrease precipitously following treatment of mice with bromocriptine, a drug that interferes with the release of prolactin from the pituitary gland and thereby inhibits milk synthesis and secretion. These results indicate that the three glycosyltransferases are developmentally regulated during the growth and differentiation of the mouse mammary gland. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOSYLTRANSFERASES
KW - BIOSYNTHESIS
KW - GLYCOPROTEINS
KW - MAMMARY glands
KW - MICE as laboratory animals
KW - LACTATION
N1 - Accession Number: 13928516; Vijay, Inder K. 1 Oka, Takami 1; Affiliation: 1: Laboratory of Molecular and Cellular Biology, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 1/2/86, Vol. 154 Issue 1, p57; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: BIOSYNTHESIS; Subject Term: GLYCOPROTEINS; Subject Term: MAMMARY glands; Subject Term: MICE as laboratory animals; Subject Term: LACTATION; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - D'Incalci, Maurizio
AU - Allavena, Paola
AU - Wu, Roy S.
AU - Bonner, William M.
T1 - H1 variant synthesis in proliferating and quiescent human cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/01/15/
VL - 154
IS - 2
M3 - Article
SP - 273
EP - 279
PB - Wiley-Blackwell
SN - 00142956
AB - The synthesis of histone H1 isoprotein species in human cells of several different types and in several different physiological states was studied. Up to five H1 and two H1° isoprotein species could be resolved by two dimensional electrophoresis. All five H1 isoprotein species were synthesized in exponentially growing cultures of IMR-90 human fibroblasts; in quiescent IMR-90 cells the synthesis of three H1 isoprotein species was greatly decreased while the synthesis of two others was much less affected. When DNA synthesis in exponentially growing cultures of IMR-90 was inhibited, the pattern of H1 isoprotein synthesis became similar to that found in quiescent cultures. Other human cells, isolated from blood, yielded similar results. These results suggest that the pattern of H1 synthesis is the same for cells in non-S phases of the cell cycle and in quiescent cells. Thus for histone H1 in human cells the relationship of the variant synthesis pattern to the growth state and DNA replication is similar to that of the core histone H3 but not that of H2A. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTONES
KW - BASIC proteins
KW - CELLS
KW - ELECTROPHORESIS
KW - ELECTROCHEMISTRY
KW - GENES
KW - DNA
N1 - Accession Number: 13930428; D'Incalci, Maurizio 1 Allavena, Paola 1 Wu, Roy S. 1 Bonner, William M. 1; Affiliation: 1: Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda.; Source Info: 1/15/86, Vol. 154 Issue 2, p273; Subject Term: HISTONES; Subject Term: BASIC proteins; Subject Term: CELLS; Subject Term: ELECTROPHORESIS; Subject Term: ELECTROCHEMISTRY; Subject Term: GENES; Subject Term: DNA; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Das, Pijush K.
AU - Murray, Gary J.
AU - Barranger, John A.
T1 - Studies n the turnover of glucocerebrosidase in cultured rat peritoneal macrophages and normal human fibroblasts.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/01/15/
VL - 154
IS - 2
M3 - Article
SP - 445
EP - 450
PB - Wiley-Blackwell
SN - 00142956
AB - The kinetics of glucocerebrosidase synthesis and degradation in rat peritoneal macrophages and in human fibroblasts have been studied using conduritol B epoxide (CBE), an irreversible and specific inhibitor of mammalian glucocerebrosidase. In cultured fibroblasts, higher concentrations of CBE and/or longer times were required for inhibition of glucocerebrosidase than were necessary for inhibition of the macrophage enzyme. However, inhibition of activity in cell extracts from both cell types showed identical time and concentration dependence. After the removal of CBE from cultures, enzyme activity returned to normal with a half-time of 48 h for macrophages and 40 h for fibroblasts. The reappearance of enzyme activity was prevented by an inhibitor of protein synthesis. Both the rate of synthesis and degradation of glucocerebrosidase enzyme protein were independent of the presence of CBE. The calculated rate of degradation of glucocerebrosidase was confirmed using metabolically labelled enzyme in cell cultures. The rate of synthesis for macrophages is 1.8 ng enzyme h-1 mg cell protcin-1 and the rate of degradation is 1.4% h-1 (0.014 h-1). These values were 2.0 ng h -1 mg -1 and 0.018 h -1 for fibroblasts. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CULTURES (Biology)
KW - MACROPHAGES
KW - HUMAN beings
KW - FIBROBLASTS
KW - CONNECTIVE tissue cells
KW - EPOXY compounds
N1 - Accession Number: 13930692; Das, Pijush K. 1 Murray, Gary J. 1 Barranger, John A. 1; Affiliation: 1: Developmental and Metabolic Neurology Branch, National Institutes of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.; Source Info: 1/15/86, Vol. 154 Issue 2, p445; Subject Term: CULTURES (Biology); Subject Term: MACROPHAGES; Subject Term: HUMAN beings; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: EPOXY compounds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Heird, William C.
AU - Grundy, Scott M.
AU - Hubbard, Van S.
T1 - Structured lipids and their use in clinical nutrition.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/02//
VL - 43
IS - 2
M3 - Article
SP - 320
EP - 324
SN - 00029165
AB - The article offers information about structured lipids and their use in clinical nutrition. The structured lipid emulsions contain medium-chain fatty acids (MCFAs) are produced by mixing fractionated medium-chain triglyceride (MCT) and long-chain triglycerides (LCT) in specific proportions, allowing hydrolysis of the fatty acids, followed by random transesterification into composite triglyceride molecules. Individual triglyceride molecules within the
KW - Nutrition
KW - Lipids
KW - Lipid metabolism
KW - Triglycerides
KW - Glycerides
N1 - Accession Number: 90667984; Heird, William C. 1; Grundy, Scott M. 2; Hubbard, Van S. 3; Affiliations: 1: Columbia University College of Physicians and Surgeons; 2: University of Texas Health Science Center, Dallas; 3: Director Nutrition Program, NIADDK, Westwood Building, Rcom 3A18B, National Institutes of Health, Bethesda, MD 20892; Issue Info: Feb1986, Vol. 43 Issue 2, p320; Thesaurus Term: Nutrition; Subject Term: Lipids; Subject Term: Lipid metabolism; Subject Term: Triglycerides; Subject Term: Glycerides; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ederer, Fred
AU - Krueger, Dean E.
AU - Mowery, Richard L.
AU - Connett, John
AU - Wentworth, Deborah
T1 - Lessons from the Visual Acuity Impairment Survey Pilot Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/02//
VL - 76
IS - 2
M3 - Article
SP - 160
EP - 165
PB - American Public Health Association
SN - 00900036
AB - Abstract: The Visual Acuity Impairment Survey (VAIS) pilot study was carried out in three large metropolitan areas of the United States to determine whether it would be feasible to conduct a large two-stage survey of the prevalence of visual acuity impairment and its causes. The study was conducted in conjunction with the Health Interview Survey (HIS), performed by the National Center for Health Statistics and the Census Bureau. In the first stage, a simple vision screening test was administered to 1,868 adults in their homes by specially trained Census Bureau interviewers. All those who failed the test, and a sample of those who passed it, were invited to a local clinic for a check on the accuracy of the screen and a detailed eye examination to establish the cause of the impairment. About 89 per ¢ of the HIS interviewees took the vision screening test in the home and agreed to have the results released, making it possible for the clinic to invite them for an examination. The principal obstacle to the success of the feasibility study was a low rate (< 50 per ¢) of participation in the clinic examination by the target population. Such low participation would leave the survey open to a serious question about its representativeness. The methods and findings of the pilot study arc presented because the lessons may be of value to those attempting similar studies in the future. Suggestions are made for methodological modifications that may enhance the chances for success. (Am J Public Health 1986; 76:160-165.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VISUAL acuity
KW - EYE -- Examination
KW - VISION testing
KW - VISION disorders
KW - VISUAL perception
KW - METROPOLITAN areas -- United States
KW - UNITED States
KW - UNITED States. Bureau of the Census
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4685648; Ederer, Fred 1 Krueger, Dean E. 2 Mowery, Richard L. 3 Connett, John 4 Wentworth, Deborah 5; Affiliation: 1: NEI Biometry and Epidemiology Program, Biostatistics Center, George Washington University 2: Research Professor of Statistics and Ophthalmology, Biostatistics Center, George Washington University 3: Health Scientist Administration, Biometry and Epidemiology Program, National Eye Institute, Building 31, room 6A2A, 9000 Rockville Pike, Bethesda, MD 20205 4: Assistant Professor, University of Minnesota Division of Biometry 5: Research Fellow, University of Minnesota Division of Biometry; Source Info: Feb1986, Vol. 76 Issue 2, p160; Subject Term: VISUAL acuity; Subject Term: EYE -- Examination; Subject Term: VISION testing; Subject Term: VISION disorders; Subject Term: VISUAL perception; Subject Term: METROPOLITAN areas -- United States; Subject Term: UNITED States; Company/Entity: UNITED States. Bureau of the Census Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mirsky, Allan F.
AU - Duncan, Connie C.
T1 - ETIOLOGY AND EXPRESSION OF SCHIZOPHRENIA: Neurobiological and Psychosocial Factors.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1986/02//
VL - 37
IS - 1
M3 - Article
SP - 291
EP - 319
PB - Annual Reviews Inc.
SN - 00664308
AB - Focuses on the etiology and expression of schizophrenia. Neurobiological and psychosocial factors of schizophrenia; Details of multifactorial etiology of schizophrenia; Factors leading to schizophrenia.
KW - SCHIZOPHRENIA
KW - DISEASES -- Causes & theories of causation
KW - NEUROSCIENCES
KW - NERVOUS system -- Diseases
N1 - Accession Number: 11266074; Mirsky, Allan F. 1 Duncan, Connie C. 1; Affiliation: 1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland 20892.; Source Info: 1986, Vol. 37 Issue 1, p291; Subject Term: SCHIZOPHRENIA; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: NEUROSCIENCES; Subject Term: NERVOUS system -- Diseases; Number of Pages: 29p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parloff, Morris B.
AU - London, Perry
AU - Wolfe, Barry
T1 - INDIVIDUAL PSYCHOTHERAPY AND BEHAVIOR CHANGE.
JO - Annual Review of Psychology
JF - Annual Review of Psychology
Y1 - 1986/02//
VL - 37
IS - 1
M3 - Article
SP - 321
EP - 349
PB - Annual Reviews Inc.
SN - 00664308
AB - Focuses on individual psychotherapy and behavior change. Developments in the field of psychotherapy; Details of meta-analytic study of psychotherapy; list of treatments of specific problems.
KW - PSYCHOTHERAPY
KW - CLINICAL sociology
KW - THERAPEUTICS
KW - PSYCHIATRY
N1 - Accession Number: 11266080; Parloff, Morris B. 1 London, Perry 2 Wolfe, Barry 3; Affiliation: 1: Department of Psychology, American University, Washington, D.C. 20016. 2: Harvard Graduate School of Education, Harvard University, Cambridge, Massachusetts 02138. 3: Psychosocial Treatments Research Branch, National Institute of Mental Health, Rock-Ville, Maryland 20857.; Source Info: 1986, Vol. 37 Issue 1, p321; Subject Term: PSYCHOTHERAPY; Subject Term: CLINICAL sociology; Subject Term: THERAPEUTICS; Subject Term: PSYCHIATRY; Number of Pages: 29p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paranjape, R. S.
AU - Hussain, Rabia
AU - Nutman, T. B.
AU - Hamilton, R.
AU - Ottesen, E. A.
T1 - Identification of circulating parasite antigen in patients with bancroftian filariasis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1986/02//
VL - 63
IS - 2
M3 - Article
SP - 508
EP - 516
PB - Wiley-Blackwell
SN - 00099104
AB - Because many cases of lymphatic filariasis cannot be diagnosed either clinically or by immunodiagnostic test based on antibody detection, recent efforts have been more directed towards developing methods for detecting parasite antigen in the blood or urine. Using A solid phase (Sepharose 4B) two-site immunoradiometric assay (IRMA) employing hyperimmune rabbit antifilarial antisera, we have previously shown (Hamilton etal; 1984) that essentially all cases of patent (ic. mierofilaremic) infection in patients with bancroftian filariasis can be detected by this semi-quantiialive assay as well as some individuals with amicrofilareirtic (i.e.. 'cryptic') infection. The present communication reports the results of studies that identify a prominent circulating antigen detected by this IRMA in sera from patients with microfilaremia. The antigen was eluted from Sepharose bound rabbit polyelonal antiserum that had been reacted with known antigen positive sera. It was run in SDS-PAGE. blotted to nitrocellulose paper and identified autoradlographically using '-M-Iabelied rabbit antifilarial antiserum. Its high molecular weight ( &tild; 200 kD). stability to acid and boiling, and sensitivity to pronase and periodate suggest its being a glycoprotein. Isolation of this antigen will permit the development of specific reagents (such as monoclonal antibodies) which should enhance both the sensitivity and utility of the currently available antigen detection systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FILARIASIS
KW - HELMINTHIASIS
KW - GEL permeation chromatography
KW - IMMUNOGLOBULINS
KW - MOLECULAR cloning
KW - MONOCLONAL antibodies
KW - filariasis circulating antigen
N1 - Accession Number: 16001793; Paranjape, R. S. Hussain, Rabia 1 Nutman, T. B. Hamilton, R. 2 Ottesen, E. A. 3; Affiliation: 1: Immunology Department, Indian Council of Medical Research-Tuberculosis Research Center, Madras, India. 2: Immunology Division, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA. 3: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1986, Vol. 63 Issue 2, p508; Subject Term: FILARIASIS; Subject Term: HELMINTHIASIS; Subject Term: GEL permeation chromatography; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: MONOCLONAL antibodies; Author-Supplied Keyword: filariasis circulating antigen; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gwirtsman, Harry E.
AU - Yager, Joel
AU - Gillard, Baiba K.
AU - Lerner, Linda
T1 - Serum Amylase and Its Isoenzymes in Normal Weight Bulimia.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 1986/02//
VL - 5
IS - 2
M3 - Article
SP - 355
EP - 361
PB - John Wiley & Sons, Inc.
SN - 02763478
AB - Bulimia is a relatively common eating disorder with many serious medical complications. In 11 normal weight patients with bulimia, serum amylase isoenzymes were elevated above control values. Both P (pancreatic origin) and S (salivary gland origin) isoenzymes were elevated to approximately equal degrees. These elevations correlated with the time elapsed since the previous meal but did not correlated with any measures of severity of bulimic behavior or clinical estimations of parotid gland enlargement. Saliva amylase was not different from controls. When serum from these patients was sent to the routine clinical chemistry laboratory, total amylase values were reported to be elevated in two patients and near the top of the normal range in an additional patient. Bulimic behavior must be added to the list of conditions that are associated with mild elevations in serum amylase. Serum amylase determination may be useful to clinicians in confirming the diagnosis of bulimia. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BULIMIA
KW - DISEASE complications
KW - WEIGHT loss
KW - ISOENZYMES
KW - PANCREAS
KW - PAROTID glands
KW - AMYLASES
KW - SALIVARY glands
KW - DIAGNOSIS
KW - EATING Disorder (Book)
N1 - Accession Number: 12072334; Gwirtsman, Harry E. 1 Yager, Joel 2 Gillard, Baiba K. 3 Lerner, Linda; Affiliation: 1: National Institute of Mental Health 2: Department of psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute 3: Assistant Professor of Medicin, Baylor College of Medicine; Source Info: Feb1986, Vol. 5 Issue 2, p355; Subject Term: BULIMIA; Subject Term: DISEASE complications; Subject Term: WEIGHT loss; Subject Term: ISOENZYMES; Subject Term: PANCREAS; Subject Term: PAROTID glands; Subject Term: AMYLASES; Subject Term: SALIVARY glands; Subject Term: DIAGNOSIS; Reviews & Products: EATING Disorder (Book); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hawley-Nelson, Pamela
AU - Berchtold, Martin W.
AU - Huitfeldt, Henrik
AU - Spiegel, Jack
AU - Yuspa, Stuart H.
T1 - Skin Calcium-Binding Protein Is a Parvalbumin of the Panniculus Carnosus.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/02//
VL - 86
IS - 2
M3 - Article
SP - 157
EP - 162
SN - 0022202X
AB - Skin calcium-binding protein (SCaBP) is a calcium binding protein purified from whole rat skin. It has a molecular weight of approximately 12,000 daltons but migrates at Mr 13,000 on sodium dodecyl sulfate (SDS)-polyacrylamide gels. On nitrocellulose blots of SDS-polyacrylamide gels, 6 different antisera to SCaBP reacted equally well with SCaBP and parvalbumin (PV), an 11,500-dalton calcium-binding protein purified from rat skeletal muscle, which also migrates at Mr 13,000 on SDS-polyacrylamide gels. Rabbit antiserum to muscle PV also recognized both PV and SCaBP, and either protein absorbed specific antibodies against either antigen from both types of antisera. Soluble protein extracts from whole adult rat and mouse skin contained a Mr 13,000 protein which was recognized on nitrocellulose blots of SDS gels by both antisera. Blots of extracts from epidermis, dermis, whole skin, and skin scraped on the dermal side to remove hypodermal tissue revealed that the Mr 13,000 PV/SCaBP cross-reacting antigen was restricted to the hypodermal tissue removed by scraping. Immunofluorescent staining of Bouin-fixed skin sections with these antisera confirmed the localization of PV/SCaBP to the panniculus carnosus, a hypodermal muscle layer. Newborn mouse skin does not contain this antigen. Additional polypeptides of Mr 10,500 and 12,000 on SDS gels of extracts from the epidermis of newborn and adult rats and mice were found to be immunoreactive with anti-SCaBp serum. These polypeptides were not recognized by the PV antiserum, and the reactivity of anti-SCaBP for these antigens was not absorbed by purified PV or SCaBP. Our results indicate that SCaBP is antigenically indistinguishable from PV and is localized in the adult rodent panniculus carnosus, and that antisera to SCaBP are poly-specific, recognizing epidermal proteins in addition to SCaBP/PV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - CALCIUM-binding proteins
KW - CALCIUM in the body
KW - CARRIER proteins
KW - IMMUNOGLOBULINS
KW - EPITHELIUM
KW - PEPTIDE hormones
N1 - Accession Number: 12284197; Hawley-Nelson, Pamela 1,2 Berchtold, Martin W. 3 Huitfeldt, Henrik 1 Spiegel, Jack 2 Yuspa, Stuart H. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. 2: Department of Biology, Catholic University of America, Washington, D.C., U.S.A. 3: Department of Cell Biology, Baylor College of Medicine, Houston, Texas.; Source Info: Feb86, Vol. 86 Issue 2, p157; Subject Term: SKIN; Subject Term: CALCIUM-binding proteins; Subject Term: CALCIUM in the body; Subject Term: CARRIER proteins; Subject Term: IMMUNOGLOBULINS; Subject Term: EPITHELIUM; Subject Term: PEPTIDE hormones; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12284197
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06433-054
AN - 2006-06433-054
AU - Hommer, Daniel W.
T1 - Hypnotics: Their Effects by Night and by Day.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1986/02//
VL - 31
IS - 2
SP - 148
EP - 149
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06433-054. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hommer, Daniel W.; Electrophysiolog Unit, Clinical Neuroscience Research Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Benzodiazepines; Cognitive Processes; Hypnotic Drugs; Sleep. Minor Descriptor: Memory. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Hindmarch, I. (Ed); Ott, H. (Ed); Roth, T. (Ed). Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1=Berlin, Federal Republic of Germany: Springer-Verlag Berlin, 1984. 231 pp. $36.50; 1984. Page Count: 2. Issue Publication Date: Feb, 1986.
AB - Reviews the book, Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1 edited by I. Hindmarch, H. Ott, and T. Roth (1984). The papers represent a variety of approaches to examining the effects of benzodiazepine hypnotics both on sleep itself and on a variety of measures of daytime performance. The overall quality of the writing and editing is quite good, and the editors have provided an extremely useful author and subject index. One disappointing aspect of this monograph is the relatively small amount of attention paid to the effects of benzodiazepines on memory. The relationship between sedation and memory is important for the clinical use of these drugs as well as for the cognitive sciences in general, it is unfortunate that this topic was not more extensively explored. Despite this shortcoming, this book provides a good summary of the current state of research regarding benzodiazepines, sleep, and performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - benzodiazepine hypnotics
KW - sleep
KW - daytime performance
KW - memory
KW - 1986
KW - Benzodiazepines
KW - Cognitive Processes
KW - Hypnotic Drugs
KW - Sleep
KW - Memory
KW - 1986
U2 - Hindmarch, I. (Ed); Ott, H. (Ed); Roth, T. (Ed). (1984); Sleep, Benzodiazepines and Performance: Experimental Methodologies and Research Prospects. Psychopharmacology Supplementum 1; Berlin, Federal Republic of Germany: Springer-Verlag Berlin, 1984. 231 pp. $36.50
DO - 10.1037/024531
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Masataka, Nobuo
AU - Symmes, David
T1 - Effect of Separation Distance on Isolation Call Structure in Squirrel Monkeys (Saimiri sciureus).
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1986/03//
VL - 10
IS - 3
M3 - Article
SP - 271
EP - 278
SN - 02752565
AB - Isolation calls of captive squirrel monkeys were recorded by separating infants from their natal group members and then permitting vocal contact between the "lost" baby and the group at systematically varied distances. Separated infants gave longer calls at greater separation distances from their natal group members, and responding adults and juveniles similarly extended the length of their vocalizations. In the longer variants, a high- frequency element was prolonged, which is considered to be an example of the net advantage of a "frequency window" in the ambient noise of environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SQUIRREL monkeys
KW - INFANTS
KW - ANIMAL behavior
KW - COMMUNICATION
KW - PRIMATES
KW - communication.
KW - infant separation
KW - Saimiri sciureus
KW - squirrel monkeys
KW - vocalizations
N1 - Accession Number: 12371878; Masataka, Nobuo 1 Symmes, David 1; Affiliation: 1: Luboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1986, Vol. 10 Issue 3, p271; Subject Term: SQUIRREL monkeys; Subject Term: INFANTS; Subject Term: ANIMAL behavior; Subject Term: COMMUNICATION; Subject Term: PRIMATES; Author-Supplied Keyword: communication.; Author-Supplied Keyword: infant separation; Author-Supplied Keyword: Saimiri sciureus; Author-Supplied Keyword: squirrel monkeys; Author-Supplied Keyword: vocalizations; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaye, Walter H.
AU - Gwirtsman, Harry
AU - George, Ted
AU - Ebert, Michael H.
AU - Petersen, Rosemary
T1 - Caloric Consumption and Activity Levels After Weight Recovery in Anorexia Nervosa: A Prolonged Delay in Normalization.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 1986/03//
VL - 5
IS - 3
M3 - Article
SP - 489
EP - 502
PB - John Wiley & Sons, Inc.
SN - 02763478
AB - In the 2 to 6 weeks after completion of refeeding and termination of a weight restoration program, patients with anorexia nervosa required greater than normal caloric intake to maintain a stable weight and had elevated levels of activity. By contrast, such patients studied 6 months or longer after weight recovery had normal caloric intake and activity levels. The prolonged delay in normalization of caloric intake and activity is mirrored by the slow resolution to normal of the neuroendocrine dysregulation that characterizes this disorder. This suggests that treatment for weight maintenance in anorexia nervosa should be extended aggressively for months after the return of a healthy weight so as to restore normal neuroendocrine function and thereby enhance the likelihood of permanent recovery. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Caloric content
KW - ANOREXIA nervosa
KW - WEIGHT gain
KW - NEUROENDOCRINOLOGY
KW - WEIGHT loss -- Endocrine aspects
KW - WEIGHT loss
N1 - Accession Number: 12064199; Kaye, Walter H. 1 Gwirtsman, Harry 2 George, Ted 2 Ebert, Michael H. 3 Petersen, Rosemary 4; Affiliation: 1: Staff Psychiatrist, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland. 2: Clinical Associates,Laboratory of Clinical Science. 3: Chairman, Department of Psychiatry,Vanderbilt University, Nashville Tennessee. 4: Clinical Nutritionist, Nutrition Department, Clinical Center NIH.; Source Info: Mar1986, Vol. 5 Issue 3, p489; Subject Term: FOOD -- Caloric content; Subject Term: ANOREXIA nervosa; Subject Term: WEIGHT gain; Subject Term: NEUROENDOCRINOLOGY; Subject Term: WEIGHT loss -- Endocrine aspects; Subject Term: WEIGHT loss; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Breathnach, Stephen M.
AU - Shimada, Shinji
AU - Kovac, Zdenko
AU - Katz, Stephen I.
T1 - Immunologic Aspects of Acute Cutaneous Graft-Versus-Host Disease: Decreased Density and Antigen-Presenting Function of Ia+ Langerhans Cells and Absent Antigen-Presenting Capacity of Ia+ Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/03//
VL - 86
IS - 3
M3 - Article
SP - 226
EP - 234
SN - 0022202X
AB - Cutaneous graft-versus-host disease (GVHD) provides a unique model for studying the pathogenesis of several important lymphocyte-mediated skin diseases. Morphologic studies have suggested that Ia antigen (Ia)-bearing epidermal Langerhans cells (LC) may be specific targets for destruction in these conditions. Keratinocytes synthesize and express Ia in GVHD and some other lymphocyte-mediated skin disorders; Ia+ keratinocytes, constitutively able to secrete epidermal cell-derived thymocyte activating factor (ETAF)/interleukin 1, may possess antigen-presenting capacity, thus leading to enhanced cutaneous immune responses and disease chronicity. We therefore investigated the fate of Ia+ LC, and the potential antigen-presenting capacity of Ia+ keratinocytes, in a murine model of GVHD. Lethally irradiated C3H/He (H-2k) mice developed acute cutaneous GVHD, and expressed keratinocyte Iak, 8 days after injection of BALB/c (H-2d) bone marrow and spleen cells. Immunofluorescence studies showed a progressive decrease in the density of Ia+ epidermal LC during the evolution of GVHD. This decrease was paralleled by a progressive reduction in the allostimulatory capacity of GVHD epidermal cells (EC) in the allogeneic EC-lymphocyte reaction (ELR). The fall in the density of Ia+ LC, and in EC allostimulatory capacity in both primary and secondary ELRs, was consistently greater in GVHD mice than in mice treated only with x-irradiation. The allostimulatory capacity of GVHD and x-irradiated EC could not be restored by addition of indomethacin or exogenous ETAF to ELR cultures. The decreased allostimulatory capacity was not the result of inhibition of the ELR, since EC from GVHD and x-irradiated mice did not cause suppression when added to control ELR cultures. The Capacity of EC to present ovalbumin, purified protein derivative of tuberculin, 2,4,6-trinitrobenzynesulfonic acid coupled to EC, and native cytochrome c (CYTc) to antigen-specific T-cell lines, clones, or hybridomas was reduced in x-irradiated mice and markedly decreased in GVHD mice. The capacity of EC from x-irradiated and GVHD mice to present CYTc fragment 81-104, which does not require further processing or catabolism by accessory cells, was similarly decreased. Taken together, the results indicate that: (1) the function of LC is markedly and progressively impaired in acute GVHD; (2) LC function is also decreased, but to a lesser extent, following x-irradiation alone; and (3) Ia + keratinocytes from lethally irradiated mice undergoing GVHD do not exhibit antigen-presenting capacity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAFT versus host disease
KW - LYMPHOCYTES
KW - SKIN diseases
KW - ANTIGENS
KW - LANGERHANS cells
KW - IA antigens
KW - KERATINOCYTES
N1 - Accession Number: 12285176; Breathnach, Stephen M. 1 Shimada, Shinji 2 Kovac, Zdenko 3 Katz, Stephen I. 2; Affiliation: 1: Department of Medicine (Dermatology), Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, U.K. 2: Dermatology Branch, National Cancer Institute, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 3: University of Zagreb, Zagreb, Croatia, Yugoslavia.; Source Info: Mar1986, Vol. 86 Issue 3, p226; Subject Term: GRAFT versus host disease; Subject Term: LYMPHOCYTES; Subject Term: SKIN diseases; Subject Term: ANTIGENS; Subject Term: LANGERHANS cells; Subject Term: IA antigens; Subject Term: KERATINOCYTES; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1523-1747.ep12285176
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maibach, Edward
AU - Gigliotti, Lillian
AU - Block, Gladys
T1 - REPORT ON THE POST'S CANCER PREVENTION SURVEY.
JO - Saturday Evening Post
JF - Saturday Evening Post
Y1 - 1986/03//
VL - 258
IS - 2
M3 - Article
SP - 66
EP - 112
PB - Saturday Evening Post Society, Inc..
SN - 00489239
AB - Presents the results of a survey on cancer prevention in the U.S. Reasons for not having regular mammographic examinations; Way to reduce the cost of the examination; Purpose of mammography; Association between diet and cancer; Effect of smoking.
KW - CANCER prevention
KW - SURVEYS
KW - MAMMOGRAMS
KW - UNITED States
N1 - Accession Number: 11649378; Maibach, Edward 1 Gigliotti, Lillian Block, Gladys; Affiliation: 1: National Cancer Institute; Source Info: Mar86, Vol. 258 Issue 2, p66; Subject Term: CANCER prevention; Subject Term: SURVEYS; Subject Term: MAMMOGRAMS; Subject Term: UNITED States; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaufmann, Nathan A.
AU - Dennis, Barbara H.
AU - Heiss, Gerardo
AU - Friedlander, Yehiel
AU - Kark, Jeremy D.
AU - Stein, Yechezkiel
T1 - Comparison of nutrient intakes of selected populations in the United States and Israel: the lipid research clinics prevalence study.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/04//
VL - 43
IS - 4
M3 - Article
SP - 604
EP - 620
SN - 00029165
AB - Nutrient intakes of 2,772 US and 2,680 Jerusalem participants of the Lipid Research Clinics Program were assessed by 24-h dietary recall in men aged 15-19 and 40-59 yr and women aged 15-19 and 35-59 yr. Energy intake was higher in the US than in Jerusalem. In Jerusalem intake of total fat ranged between 32.2-33.7% of kcal, of saturated fatty acids (SFA) between 9.8-10.9%, of polyunsaturated fatty acids (PFA) between 7.9-8.6%, of carbohydrates between 50.5-53.9%, and of starch between 24.0-30.5%. The P:S ratio ranged between 0.80 and 1.01. The corresponding ranges for the US were 38.8-40.8% for fat, 14.3-15.9% for SFA, 5.9-6.8% for PFA, 38.9-46.2% for carbohydrates, 17.0-17.9% for starch, and 0.40-0.53 for the P:S ratio. Intake of cholesterol (mg/1000 kcal) was higher in Jerusalem than in the US. These data address the feasibility of reducing fat in diets of free-living, Western populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Saturated fatty acids
KW - Carbohydrates
KW - Jerusalem
KW - United States
KW - Israel
KW - dietary carbohydrates
KW - dietary cholesterol
KW - dietary fats
KW - Nutrition survey
N1 - Accession Number: 91096106; Kaufmann, Nathan A. 1; Dennis, Barbara H. 2; Heiss, Gerardo 3; Friedlander, Yehiel 4; Kark, Jeremy D. 5; Stein, Yechezkiel 4; Affiliations: 1: Department of Nutrition, Hebrew University--Hadassah Medical School, Jerusalem, Israel; 2: Lipid Metabolism-Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; 3: Lipid Research Clinics Program and Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC; 4: Jerusalem Lipid Research Clinic, Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel; 5: Department of Social Medicine, Hebrew University--Hadassah School of Public Health and Community Medicine, Jerusalem, Israel; Issue Info: Apr1986, Vol. 43 Issue 4, p604; Subject Term: Saturated fatty acids; Subject Term: Carbohydrates; Subject: Jerusalem; Subject: United States; Subject: Israel; Author-Supplied Keyword: dietary carbohydrates; Author-Supplied Keyword: dietary cholesterol; Author-Supplied Keyword: dietary fats; Author-Supplied Keyword: Nutrition survey; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - La Vecchia, Carlo
AU - Decarli, Adriano
T1 - Trends in Ischemic Heart Disease Mortality in Italy, 1968-78.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/04//
VL - 76
IS - 4
M3 - Article
SP - 454
EP - 456
PB - American Public Health Association
SN - 00900036
AB - Abstract: In Italy during the period 1968-78, female heart disease mortality decreased in all age groups up to age 79, with an average annual rate of decline in the 35-74 age-standardized rate of over 0.7 per ¢. In males, age-specific death rates in some age groups were stable or increased moderately, but in middle-aged (50 to 59) males there was a consistent increase so that the rise in the 35-74 age standardized male death rate was approximately 1 per ¢ per year. (Am J Public Health 1986; 76:454-456.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY heart disease
KW - MORTALITY -- Statistics
KW - HEART diseases in women
KW - MALES
KW - AGE groups
KW - DEATH
KW - HEART diseases
KW - PUBLIC health
KW - ITALY
N1 - Accession Number: 4686467; La Vecchia, Carlo 1 Decarli, Adriano 2; Affiliation: 1: Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy. 2: Institute of Medical Statistics, University of Milan and National Cancer Institute, Milan.; Source Info: Apr1986, Vol. 76 Issue 4, p454; Subject Term: CORONARY heart disease; Subject Term: MORTALITY -- Statistics; Subject Term: HEART diseases in women; Subject Term: MALES; Subject Term: AGE groups; Subject Term: DEATH; Subject Term: HEART diseases; Subject Term: PUBLIC health; Subject Term: ITALY; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Goldman, Howard H.
AU - Morrtssey, Joseph P.
T1 - Response from Drs. Goldman and Morrissey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/04//
VL - 76
IS - 4
M3 - Letter
SP - 464
EP - 464
PB - American Public Health Association
SN - 00900036
AB - A response by Howard H. Goldman and Joseph P. Morrissey to a letter to the editor about their article on the policy of community mental health centers is presented.
KW - LETTERS to the editor
KW - MENTAL health policy
N1 - Accession Number: 22478436; Goldman, Howard H. 1 Morrtssey, Joseph P. 2; Affiliation: 1: Assistant Director, National Institute of Mental Health, Rockville, MD 2: Senior Research Sociologist, Office of Mental Health, New York State, Albany; Source Info: Apr1986, Vol. 76 Issue 4, p464; Subject Term: LETTERS to the editor; Subject Term: MENTAL health policy; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 1/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bender, B. S.
AU - Auger, F. A.
AU - Quinn, T. C.
AU - Redfield, R.
AU - Gold, J.
AU - T. M. Folks
T1 - Impaired antibody-dependent cell-mediated cytotoxic activity in patients with the acquired immunodeficiency syndrome.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1986/04//
VL - 64
IS - 1
M3 - Article
SP - 166
EP - 172
PB - Wiley-Blackwell
SN - 00099104
AB - Since the acquired immunodeficiency syndrome (AIDS) is characterized by opportunistic infections and malignancies indicative of a profound suppression in cell-mediated immunity, we investigated the antibody-dependent cell-mediated cytotoxicity (ADCC) of peripheral blood mononuclear cells of patients with AIDS against chicken red blood cells (CRBC). A marked decrease in ADCC-CRBC activity was observed from patients with AIDS as compared lo healthy controls. Furthermore, suppression in ADCC activity was seen when mononuclear cells from healthy subjects were assayed using media containing 25% or 40% sera from AIDS patients. Two of two patients with AIDS and impaired ADCC-CRBC activity were also found to have in vivo impaired reticuloendothelial system Fc-specific clearance of 15Cr-labelled, anti-Rho (D) IgG-sensitized autologous erythrocytes. These data provide further evidence of monocyte-macrophage dysfunction in AIDS and help explain the widespread occurrence of opportunistic pathogens in AIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - AIDS patients
KW - INFECTION
KW - BLOOD cells
KW - KILLER cells
KW - BLOOD plasma
KW - CELLULAR immunity
KW - AIDS
KW - antibody-dependent cell-mediated cytotoxicity
KW - monocytes
N1 - Accession Number: 16178729; Bender, B. S. 1,2 Auger, F. A. 3 Quinn, T. C. 2,4 Redfield, R. 5 Gold, J. 6 T. M. Folks 3; Affiliation: 1: Clinical Immunology Section, National Institute on Aging, NIH. 2: Division of Infectious Diseases, Johns Hopkins Hospital. 3: Office of Scientific Director, National Institute of Allergy and Infectious Disease, NIH. 4: Laboratory of Clinical Investigation, National Institute of Allergy and Infections Disease, NIH. 5: Walter Reed Army Medical Research Institute . 6: Division of Infectious Diseases, Memorial Sloan Kettering Hospital, USA.; Source Info: Apr1986, Vol. 64 Issue 1, p166; Subject Term: CELL-mediated cytotoxicity; Subject Term: AIDS patients; Subject Term: INFECTION; Subject Term: BLOOD cells; Subject Term: KILLER cells; Subject Term: BLOOD plasma; Subject Term: CELLULAR immunity; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: antibody-dependent cell-mediated cytotoxicity; Author-Supplied Keyword: monocytes; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rozenszajn, L. A.
AU - Muellenberg-Coulombre, C.
AU - Gery, I.
AU - El-Saied, M.
AU - Kuwabara, T.
AU - Mochizuki, M.
AU - Lando, Z.
AU - Nussenblatt, R. B.
T1 - Induction of experimental autoimmune uveoretinitis by T-cell lines.
JO - Immunology
JF - Immunology
Y1 - 1986/04//
VL - 57
IS - 4
M3 - Article
SP - 559
EP - 565
PB - Wiley-Blackwell
SN - 00192805
AB - Experimental autoimmune uveoretinitis was induced in genetically susceptible Lewis rats by passive transfer of T-lymphocyte cell lines from long-term cultures primed against soluble retinal antigen (S- Ag). A continuous T-cell line was established from non-adherent lymph node cells of S-Ag- immunized Lewis rats. The lymphoid cells were propagated in vitro by serially restimulating them with S-Ag in the presence of irradiated syngeneic spleen cells and expanding them in IL-2-containing media. The cell lines exhibited markers specific for T lymphocytes and the majority had the helper phenotype. When naive rats were inoculated intravenously with anti S-Ag T-cell lines re-exposed to the antigen prior to injection, they developed uveoretinitis with both clinical and histological characteristics in half the time required by S-Ag to induce the disease by active immunization. The rats exhibited a delayed hypersensitivity skin reaction towards S-Ag. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNE diseases
KW - T cells
KW - LYMPHOCYTES
KW - CELL lines
KW - RATS
KW - CELL culture
N1 - Accession Number: 14005228; Rozenszajn, L. A. 1 Muellenberg-Coulombre, C. 2 Gery, I. 2 El-Saied, M. 2 Kuwabara, T. 2 Mochizuki, M. 2 Lando, Z. 2 Nussenblatt, R. B. 2; Affiliation: 1: National Eye Institute, Clinical Branch and the Laboratory of Vision Research, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland, U.S.A. 2: Department of Life Sciences, Bar-Han University, Ramat-Gran, 52100 Israel.; Source Info: Apr86, Vol. 57 Issue 4, p559; Subject Term: AUTOIMMUNE diseases; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: CELL lines; Subject Term: RATS; Subject Term: CELL culture; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cooper, Kevin D.
AU - Neises, Gabrielle R.
AU - Katz, Stephen I.
T1 - Antigen-Presenting OKM5+ Melanophages Appear in Human Epidermis After Ultraviolet Radiation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/04//
VL - 86
IS - 4
M3 - Article
SP - 363
EP - 370
SN - 0022202X
AB - Ultraviolet radiation of murine skin in vivo or epidermal cells (EC) in vitro dramatically inhibits the antigen-presenting capacity of EC in vitro and results in the inhibition of immune responses to antigen challenge. In humans, UV exposure in vivo markedly inhibits alloantigen presentation by EC in the EC-lymphocyte reaction (ELR) when EC arc harvested immediately after the administration of 4 times the minimal erythema dose (4 MED), whereas EC harvested 72 h after 4 MED (UV-EC) exhibit enhanced allostimulatory capacity in the ELR. This enhanced ELR reactivity is due to the appearance, in the epidermis, of bone marrow-derived OKT6- DR+ cells which are distinct from Langerhans cells (LC) in their lack of surface OKT6 and in their ultrastructural morphology. This report focuses on the phenotype and function of T6- Dr+ UV-EC and on their relationship to known human antigen presenting cell (APC) subsets. Approximately 60% of T6- Dr+ UV-EC bore the monocyte marker defined by monoclonal antibody OKM5, but lacked determinants recognized by OKM1, LeuM1, LeuM3, LeuM4, LeuM5, and Mac1. All T6- Dr+ UV-EC bore the class II MHC antigen HLA-DQ (DC/DS), which is associated with a specialized subset of antigen-presenting monocytes capable of stimulation in the autologous mixed leukocyte reaction (AMLR). Panning of OKM5+ UV-EC resulted in a population of cells which was markedly enriched in melanophages and which exhibited potent alloantigen-presenting capacity in the ELR. Since OKM5+ T6- Dr+ UV- EC were similar to the specialized APC minor subset of OKM1- OKM5+ blood monocytes both in phenotype and in apparent phagocytic function, we examined other APC functions of UV-EC to assess the extent of this analogy. Relative to control of EC (containing only LC as APC), UV-EC (containing functionally inactivated LC but many T6-Dr+ APC) induced significantly greater degrees of T-cell proliferation in the presence of either tetanus toxoid antigen or the mitogen concanavalin A, UV-EC, as well as panning-purified OKM5+ UV-EC, were also able to induce autologous T-cell proliferation in the absence of added antigen (autologous ERL) in contrast to control EC which were poor stimulators of an autologous ELR. Thus, although human EC 72 h after UV exposure are numerically and functionally depleted of LC, at least 2 additional subsets of T6- Dr+ APC appear in the epidermis. One of these subsets is OKMI-OKM5- DQ+. The major subset is OKMI-OKM5- DQ+ and appears phenotypically and functionally analogus to the highly specialized OKM1- OKM5+ subset of blood monocytes capable of phagocytosis, soluble antigen presentaiton, and stimulation in the AMLR. These non-LC APC subsets may be involved in altered APC-T cell actiation mechanisms when skin is irradiated with UV in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - IMMUNE response
KW - ANTIGENS
KW - ERYTHEMA
KW - MONOCYTES
KW - PHENOTYPE
KW - BONE marrow
N1 - Accession Number: 12285600; Cooper, Kevin D. 1 Neises, Gabrielle R. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr86, Vol. 86 Issue 4, p363; Subject Term: ULTRAVIOLET radiation; Subject Term: IMMUNE response; Subject Term: ANTIGENS; Subject Term: ERYTHEMA; Subject Term: MONOCYTES; Subject Term: PHENOTYPE; Subject Term: BONE marrow; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12285600
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodley, David T.
AU - Kalebec, Tea
AU - Banes, Albert J.
AU - Link, William
AU - Prunieras, Michel
AU - Liotta, Lance
T1 - Adult Human Keratinocytes Migrating over Nonviable Dermal Collagen Produce Collagenolytic Enzymes That Degrade Type I and Type IV Collagen.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/04//
VL - 86
IS - 4
M3 - Article
SP - 418
EP - 423
SN - 0022202X
AB - Human adult keratinocytes migrating on a nonviable dermal substrate in cultures without fibroblasts induce thinning and degradation of the collagen substrate beneath the migrating epithelium. Further, unconcentrated conditioned medium from the cultures exhibit collagenolytic activity against both type I and type IV collagen which is inhibited by EDTA but not by phenylmethylsulfonyl fluoride or N-ethylmaleimide. Since the migrating epithelium and dermal substrate do not contain fibroblasts, this study shows that migratory keratinocytes in contact with interstitial collagen are capable of producing collagenases against type I and type IV collagen. Moreover, migratory keratinocytes appear to be similar to highly metastatic cells in their ability to degrade basement membrane collagen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATINOCYTES
KW - FIBROBLASTS
KW - COLLAGEN
KW - EPITHELIUM
KW - ETHYLENEDIAMINETETRAACETIC acid
KW - CELLS
N1 - Accession Number: 12285689; Woodley, David T. 1 Kalebec, Tea 2 Banes, Albert J. 3 Link, William 3 Prunieras, Michel 4 Liotta, Lance 2; Affiliation: 1: Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina. 2: Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland, U.S.A. 3: Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina. 4: Department of Cell Biology, Center for International Dermatologic Research, Valbonne, France.; Source Info: Apr86, Vol. 86 Issue 4, p418; Subject Term: KERATINOCYTES; Subject Term: FIBROBLASTS; Subject Term: COLLAGEN; Subject Term: EPITHELIUM; Subject Term: ETHYLENEDIAMINETETRAACETIC acid; Subject Term: CELLS; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12285689
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GILDEN, RAYMOND V.
AU - GONDA, MATTHEW A.
AU - SARNGADHARAN, M. G.
AU - POPOVIC, MIKULAS
AU - GALLO, ROBERT C.
T1 - HTLV-III Legend Correction.
JO - Science
JF - Science
Y1 - 1986/04/18/
VL - 232
IS - 4748
M3 - Article
SP - 307
EP - 307
SN - 00368075
N1 - Accession Number: 87436691; GILDEN, RAYMOND V. 1 GONDA, MATTHEW A. 1 SARNGADHARAN, M. G. 2 POPOVIC, MIKULAS 3 GALLO, ROBERT C. 3; Affiliation: 1: Program Resources, NCI-Frederick Cancer Research Facility, Frederick, AMD 21701 2: Department of Cell Biology, Biohetics, Inc., Kensington, MD 20895 3: Laboratory ofTumor Cell Bwlogy, National Cancer Institute, Bethesda, AM 20892; Source Info: 4/18/1986, Vol. 232 Issue 4748, p307; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wayne, Robert K.
T1 - Origins of the Domestic Dog: The Fossil Record (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1986/05//May/Jun86
VL - 74
IS - 3
M3 - Book Review
SP - 316
EP - 317
SN - 00030996
AB - Reviews the book 'Origins of the Domestic Dog: The Fossil Record,' by Stanley J. Olsen.
KW - Dogs
KW - Nonfiction
KW - Olsen, Stanely J.
KW - Origins of the Domestic Dog (Book)
N1 - Accession Number: 11232722; Wayne, Robert K. 1; Affiliations: 1: National Cancer Institute; Issue Info: May/Jun86, Vol. 74 Issue 3, p316; Thesaurus Term: Dogs; Subject Term: Nonfiction; Reviews & Products: Origins of the Domestic Dog (Book); NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; People: Olsen, Stanely J.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gerstenblith, Gary
AU - Lakatta, Edward G.
T1 - Geriatric hypertension: Aggressive therapy and its physiologic rationale.
JO - Geriatrics
JF - Geriatrics
Y1 - 1986/05//
VL - 41
IS - 5
M3 - Article
SP - 44
EP - 53
SN - 0016867X
N1 - Accession Number: 17333536; Gerstenblith, Gary 1; Lakatta, Edward G. 2,3,4; Source Information: May1986, Vol. 41 Issue 5, p44; Number of Pages: 8p; Illustrations: 6 Graphs; Document Type: Article; Full Text Word Count: 4317
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Furuichi, K.
AU - Ra, C.
AU - Isersky, C.
AU - Rivera, J.
T1 - Comparative evaluation of the effect of pharmacological agents on endocytosis and coendocytosis of IgE by rat basophilic leukaemia cells.
JO - Immunology
JF - Immunology
Y1 - 1986/05//
VL - 58
IS - 1
M3 - Article
SP - 105
EP - 110
PB - Wiley-Blackwell
SN - 00192805
AB - The aggregation of IgE bound to rat basophilic leukaemia (RBL) cells leads to the exocytosis of mediators, the endocytosis of the antigen-aggregated mouse IgE anti-DNP, as well as the coendocytosis of some unaggregated monomeric rat IgE (IR162) and/or unbound receptors. We describe here the relative effect on endocytosis and coendocytosis of various pharmacological agents that block or enhance exocytosis. We have previously shown that, unlike exocytosis, endocytosis by RBL and normal rat mast cells was independent of extracellular calcium. We show here that the presence of calcium chelators or antagonists also had no effect on endocytosis of cross-linked IgE. However, coendocytosis of non-cross-linked IgE was partially inhibited by the elimination of extracellular calcium and the addition of calcium chelators such as EDTA or EGTA-Mg2+. Moreover, the addition of calcium antagonists such as Ni2+ and Co2+ (5 mM) to an incubation mixture containing Ca2+ (1 mM) resulted in the complete inhibition of coendocytosis without affecting endocytosis. Other inhibitors of exocytosis such as sodium azide (10-2 M), quercetin (10-2 M) and dibutyryl cyclic AMP (10-2 M) blocked coendocytosis completely but had no effect on endocytosis. Sodium azide (10 mM) in combination with 2-deoxyglucose (10 mM) effectively inhibited (90%) endocytosis. Cytochalasin B (10-4 M), which was shown to enhance serotonin release, had no effect on the extent of endocytosis or coendocytosis observed 20 min after the initiation of aggregation. Thus, in RBL cells, endocytosis, coendocytosis and exocytosis exhibit distinguishable sensitivities to some pharmacological drugs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOCYTOSIS
KW - BASOPHILS
KW - LEUKEMIA
KW - RATS as laboratory animals
KW - MAST cells
KW - EXOCYTOSIS
N1 - Accession Number: 14004897; Furuichi, K. 1 Ra, C. 1 Isersky, C. 1 Rivera, J. 1; Affiliation: 1: Section on Chemical Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May86, Vol. 58 Issue 1, p105; Subject Term: ENDOCYTOSIS; Subject Term: BASOPHILS; Subject Term: LEUKEMIA; Subject Term: RATS as laboratory animals; Subject Term: MAST cells; Subject Term: EXOCYTOSIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Löe, H.
AU - Anerud, A.
AU - Boysen, H.
AU - Morrison, E.
T1 - Natural history of periodontal disease in man: Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age.
T2 - Der natürliche Verlauf der menschlichen Parodontalkrankheit Rapider, mässiger und kein Attachmentverlust bei Arbeirern im Alter von 14 46 Jahren in Sri Lanka.
T2 - Histoire naturelle de la maladie parodontale chez l'hamme. Perte d'attache rapide, modérée ou absente chez des travailleurs sri lankais âgés de 14 à 46 ans.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1986/05//
VL - 13
IS - 5
M3 - Article
SP - 431
EP - 440
SN - 03036979
AB - This paper describes the initiation, rate of progress of periodontal disease and consequent tooth loss in a population never exposed to any programs or incidents relative to prevention and treatment of dental diseases. The group consisted of 480 male laborers at two tea plantations in Sri Lanka. The study design and baseline data have been published. At the initial examination in 1970, the age of the participants ranged between 14 and 31 years. Subsequent examinations occurred in 1971, 1973, 1977, 1982 and 1985. Thus, the study covers the age range 14 46 years. Throughout the study, the clinical indices were scored by the same two examiners, both well-trained and experienced periodontitis. Intra-examiner reproducibility for each index was tested at baseline and repeated periodically during the study. The data for each examination were computerized and updated on an ongoing basis. At the last examination in 1985, there were 161 individuals who had participated in the first survey. This population did not perform any conventional oral hygiene measures and consequently displayed quite uniformly large aggregates of plaque, calculus and stain on their teeth. Virtually all gingival units exhibited inflammation. Based on interproximal loss of attachment and tooth mortality rates, three subpopulations were identified: (1) individuals (∼ 8%) with rapid progression of periodontal disease (RP), those (∼ 81 %) with moderate progression (MP), and a group (∼ 11 %) who exhibited no progression (NP) of periodontal disease beyond gingivitis. At 35 years of age, the mean loss of attachment in the RP group was ∼ 9 mm, the MP group had ∼ 4 mm and the NP group had less than 1 mm loss of attachment. At the age of 45 years, the mean loss of attachment in the RP group was ∼ 13 mm and the MP group ∼ 7 mm. The annual rate of destruction in the BY group varied between 0.1 and 1.0 mm, in the MP group between 0.05 and 0.5 mm, and in the NP group between 0.05 and 0.09 mm. Since this population was virtually caries free, essentially all missing teeth were lost due to periodontal disease. In the RP group, tooth loss already occurred at 20 years of age and increased throughout the next 25 years. At 35 years of age, 12 teeth had been lost, at 40 years of age 20 teeth were missing and at 45 all teeth were lost. In the MP groups, tooth mortality started after 30 years of age and increased throughout the decade. At 45 years of age, the mean loss of teeth in this group was 7 teeth. The NP group essentially showed no tooth loss. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTAL disease
KW - TOOTH loss
KW - PERIODONTITIS
KW - GINGIVITIS
KW - CLINICAL trials
KW - ORAL hygiene
KW - loss of attachment
KW - moth loss.
KW - Natural history
KW - periodontal disease
N1 - Accession Number: 13602740; Löe, H. 1 Anerud, A. 1 Boysen, H. 1 Morrison, E. 1; Affiliation: 1: National Institute of Dental Research, National Institutes of Health, Bethesda Maryland, USA; Source Info: May1986, Vol. 13 Issue 5, p431; Subject Term: PERIODONTAL disease; Subject Term: TOOTH loss; Subject Term: PERIODONTITIS; Subject Term: GINGIVITIS; Subject Term: CLINICAL trials; Subject Term: ORAL hygiene; Author-Supplied Keyword: loss of attachment; Author-Supplied Keyword: moth loss.; Author-Supplied Keyword: Natural history; Author-Supplied Keyword: periodontal disease; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1600-051X.ep13602740
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morrison, Edith C.
AU - Kowalski, Charles J.
T1 - Discussion: Clinical measurements of periodontitis.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1986/05//
VL - 13
IS - 5
M3 - Article
SP - 456
EP - 458
SN - 03036979
AB - The article comments on the use of sequential linear regression (SLR) analysis to monitor patients with periodontal disease. The model is at least relatively realistic and that its attendant assumptions are satisfied. If one believes in the random burst hypothesis, choosing the SLR model is choosing a model believed to be inappropriate. Indeed, the SLR model would be the model of choice only if one believed that periodontal disease was a continuous, progressive process. The SLR model is logically inconsistent with the random burst hypothesis.
KW - PERIODONTAL disease
KW - REGRESSION analysis
KW - STATISTICS
KW - RANDOM variables
KW - CORRELATION (Statistics)
KW - PERIODONTITIS
N1 - Accession Number: 13602781; Morrison, Edith C. 1 Kowalski, Charles J. 2; Affiliation: 1: National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA 2: Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Source Info: May1986, Vol. 13 Issue 5, p456; Subject Term: PERIODONTAL disease; Subject Term: REGRESSION analysis; Subject Term: STATISTICS; Subject Term: RANDOM variables; Subject Term: CORRELATION (Statistics); Subject Term: PERIODONTITIS; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1600-051X.ep13602781
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carlos, James P.
T1 - Summary and looking to the future.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1986/05//
VL - 13
IS - 5
M3 - Article
SP - 547
EP - 548
SN - 03036979
AB - The article presents a brief summary of a conference on Clinical Trials in Periodontal Disease. The existing epidemiological data on gingivitis, presents a totally confusing and really a virtually useless body of information. It was stated that there are a number of indices available and in use to measure gingivitis, all of which, or none of which are satisfactory, depending upon one's point of view. A particularly significant issue, which arose, was the discussion of the perils of using a so-called active control without placebo in these trials. It was pointed out that to do so requires a strong faith in the idea that the results of earlier trials will always recur; that an agent once shown to be effective will continue to be effective in all future circumstances.
KW - PERIODONTAL disease
KW - CLINICAL trials
KW - EPIDEMIOLOGY
KW - GINGIVITIS
KW - INDEXES
KW - ORAL hygiene
N1 - Accession Number: 13603798; Carlos, James P. 1; Affiliation: 1: National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA; Source Info: May1986, Vol. 13 Issue 5, p547; Subject Term: PERIODONTAL disease; Subject Term: CLINICAL trials; Subject Term: EPIDEMIOLOGY; Subject Term: GINGIVITIS; Subject Term: INDEXES; Subject Term: ORAL hygiene; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-051X.ep13603798
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kripke, Margaret L.
AU - Morison, Warwick L.
T1 - Studies on the Mechanism of Systemic Suppression of Contact Hypersensitivity by UVB Radiation. II. Differences in the Suppression of Delayed and Contact Hypersensitivity in Mice.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/05//
VL - 86
IS - 5
M3 - Article
SP - 543
EP - 549
SN - 0022202X
AB - Exposing mice to UV radiation in the UVB range (280-320 nm) causes a selective immune suppression that contributes to the development of UVB-induced skin cancers. Among the immune responses suppressed by UVB irradiation are contact and delayed hypersensitivity reactions to haptens administered at unexposed sites. In these studies we provide evidence that delayed and contact hypersensitivity to the same hapten are not equivalent reactions and that they are suppressed in UVB-irradiated mice by 2 different mechanisms. This conclusion is based on the findings that: (1) suppression of contact hypersensitivity could not be overcome by immunizing UVB-irradiated mice with hapten-coupled antigen-presenting cells derived from normal donors; and (2) treatment of UVB-irradiated mice with methylprednisolone before immunization prevented the suppression of delayed hypersensitivity but had no effect on the suppression of contact hypersensitivity. The decreased ability to induce contact hypersensitivity in UVB-irradiated mice could be transferred to x-irradiated mice by reconstituting them with spleen cells from UVB- irradiated donors. The induction of hapten-specific suppressor cells, however, required both UVB irradiation and priming with hapten. Based on these results, we postulate that UVB irradiation induces a population of suppressor-inducer cells with specificity for a modified skin antigen and that this antigen serves as a carrier molecule for haptens that induce contact hypersensitivity and for tumor-specific transplantation antigens on UVB-induced tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNITY
KW - HAPTENS
KW - TUMORS
KW - ULTRAVIOLET radiation
KW - IRRADIATION
KW - MICE as laboratory animals
KW - CONTACT dermatitis
N1 - Accession Number: 12355000; Kripke, Margaret L. 1 Morison, Warwick L. 2; Affiliation: 1: University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas. 2: National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland, U.S.A.; Source Info: May86, Vol. 86 Issue 5, p543; Subject Term: IMMUNITY; Subject Term: HAPTENS; Subject Term: TUMORS; Subject Term: ULTRAVIOLET radiation; Subject Term: IRRADIATION; Subject Term: MICE as laboratory animals; Subject Term: CONTACT dermatitis; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12355000
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06436-023
AN - 2006-06436-023
AU - Tabakoff, Boris
T1 - Tolerance and Dependence: Novel Concepts and Molecular Mechanisms.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1986/05//
VL - 31
IS - 5
SP - 357
EP - 358
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06436-023. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Dependency; Drug Tolerance; Electrophysiology. Minor Descriptor: Biochemistry; Pharmacology. Classification: Physiological Psychology & Neuroscience (2500); Substance Abuse & Addiction (3233). Population: Human (10). Reviewed Item: Sharp, Charles W. (Ed). Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54=Rockville, MD: National Institute on Drug Abuse, 1984. 389 pp. Free paperback; 1984. Page Count: 2. Issue Publication Date: May, 1986.
AB - Reviews the book, Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54 by Charles W. Sharp (Ed.) (1984). The contributors to this book deftly review the current research on the cellular mechanisms by which drug tolerance and dependence are manifest. The contributors' efforts are concentrated on attempts to define the molecular and physiologic events that are generated by the continued exposure of neurons to opiates, barbiturates, amphetamines, cocaine, and nicotine. The monograph succeeds in presenting a detailed discourse in the areas of biochemical pharmacology and electrophysiology, but little attention is devoted to behavioral theories of tolerance and dependence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug tolerance
KW - drug dependence
KW - biochemical pharmacology
KW - electrophysiology
KW - behavioral theory
KW - neurons
KW - 1986
KW - Drug Dependency
KW - Drug Tolerance
KW - Electrophysiology
KW - Biochemistry
KW - Pharmacology
KW - 1986
U2 - Sharp, Charles W. (Ed). (1984); Mechanisms of Tolerance and Dependence. NIDA Research Monograph 54; Rockville, MD: National Institute on Drug Abuse, 1984. 389 pp. Free paperback
DO - 10.1037/024748
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SHEN, D.-W.
AU - FOJO, A.
AU - CHIN, J. E.
AU - RONINSON, I. B.
AU - RICHERT, N.
AU - PASTAN, I.
AU - GOTTESMAN, M. M.
T1 - Human Mulidrug-Resistant Cell Lines: Increased mdrl Expression Can Precede Gene Amplificaton.
JO - Science
JF - Science
Y1 - 1986/05/02/
VL - 232
IS - 4750
M3 - Article
SP - 643
EP - 645
SN - 00368075
AB - The development of simultaneous resistance to multiple structurally unrelated drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human KB carcinoma cells selected in colchicine, vinblastine, or Adriamycin is associated with amplification of specific DNA sequences (the multidrug resistance locus, mdrl). During colchicine selection resistance is initially accompanied by elevated expression of a 4.5-kilobase mdrl messenger RNA (mRNA) without amplification of the corresponding genomic sequences. During selection for inceased levels of resistance, expression of this mRNA is increased simultaneously with amplification of mdrl DNA. Increased expression and amplification of mdrl sequences were also found-in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells. These results suggest that increased expression ofmdrl mRNA is a common mechanism for multidrug resistance in human cells. Activation of the mdrl gene by mutations or epigenetic changes may precede its amplification during the development of resistance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87437269; SHEN, D.-W. 1 FOJO, A. 1 CHIN, J. E. 2 RONINSON, I. B. 2 RICHERT, N. 3 PASTAN, I. 3 GOTTESMAN, M. M. 3; Affiliation: 1: Laboratory ofMolecular Biology, National Cancer Institute, Betesda, MD 20892 2: Center for Genetics, University of Illinois College of Medicine at Chicago, Chicago, IL 60612 3: Laboratory of Molecular Biology, National Cancer Institutc, Bethesda, MD 20892; Source Info: 5/2/1986, Vol. 232 Issue 4750, p643; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WALDMANN, THOMAS A.
T1 - The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes.
JO - Science
JF - Science
Y1 - 1986/05/09/
VL - 232
IS - 4751
M3 - Article
SP - 727
EP - 732
SN - 00368075
AB - Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33,000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55,000-dalton form. In contrast to resting T cells, human T-cell lymphotrophic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546959; WALDMANN, THOMAS A. 1; Affiliation: 1: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/9/1986, Vol. 232 Issue 4751, p727; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RENLUND, MARTIN
AU - TIETZE, FRANK
AU - GAHL, WILLIAM A.
T1 - Defective Sialic Acid Egress from Isolated Fibroblast Lysosomes of Patients with Salla Disease.
JO - Science
JF - Science
Y1 - 1986/05/09/
VL - 232
IS - 4751
M3 - Article
SP - 759
EP - 762
SN - 00368075
AB - Normal fibroblasts exposed to N-acetylmannosamine yielded lysosome-rich granular fractions loaded with free (unbound) sialic acid, whose velocity of egress increased with increasing initial loading. Fibroblast granular fractions of patients with Salla disease exhibited negligible egress of sialic acid, whether endogenous or derived from N-acetylmannosamine exposure. Salla disease represents the first disorder demonstrated to be caused by defective transport of a monosaccharide out of cellular lysosomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546953; RENLUND, MARTIN 1,2 TIETZE, FRANK 3 GAHL, WILLIAM A. 1; Affiliation: 1: Section on Human Biochemical Genetics, Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 2: Children's Hospital, Helsinki University Central Hospital, 00290 Helsinki, Finland 3: Section on Developmental Biology, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892; Source Info: 5/9/1986, Vol. 232 Issue 4751, p759; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NELSON, THOMAS
AU - LUCIGNANI, GIOVANNI
AU - SOKOLOFF, LOUIS
T1 - Measurement of Brain Deoxyglucose Metabolism by NMR.
JO - Science
JF - Science
Y1 - 1986/05/09/
VL - 232
IS - 4751
M3 - Article
SP - 776
EP - 777
SN - 00368075
N1 - Accession Number: 87546936; NELSON, THOMAS 1 LUCIGNANI, GIOVANNI 1 SOKOLOFF, LOUIS 1; Affiliation: 1: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20205; Source Info: 5/9/1986, Vol. 232 Issue 4751, p776; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GERSHON, ELLIOT S.
T1 - Quality of Intramural Research.
JO - Science
JF - Science
Y1 - 1986/05/23/
VL - 232
IS - 4753
M3 - Article
SP - 919
EP - 919
SN - 00368075
N1 - Accession Number: 87546980; GERSHON, ELLIOT S. 1,2; Affiliation: 1: Office of Science, Alcohol, Drug Abuse, and Mental Health Administration, RockviUe, MD 20857 2: Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p919; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BAX, AD
AU - LERNER, LAURA
T1 - Two-Dimensional Nuclear Magnetic Resonance Spectroscopy.
JO - Science
JF - Science
Y1 - 1986/05/23/
VL - 232
IS - 4753
M3 - Article
SP - 960
EP - 967
SN - 00368075
AB - Great spectral simplification can be obtained by spreading the conventional one-dimensional nuclear magnetic resonance (NMR) spectrum in two independent frequency dimensions. This so-called two-dimensional NMR spectroscopy removes spectral overlap, facilitates spectral assignment, and provides a wealth of additional information. For example, conformational information related to interproton distances is available from resonance intensities in certain types of two-dimensional experiments. Another method generates 1H NMR spectra of a preselected fragment of the molecule, suppressing resonances from other regions and greatly simplifyig spectral appearance. Two-dimensional NMR spectroscopy can also be applied to the study of 13C and 15N, not only providing valuable connectivity information but also improving sensitivity of 13C and 15N detection by up to two orders of magnitude. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546975; BAX, AD 1 LERNER, LAURA 1; Affiliation: 1: Laboratory of Chemical Physics, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p960; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MAJEWSKA, MARIA DOROTA
AU - HARRISON, NEIL L.
AU - SCHWARTZ, ROCHELLE D.
AU - BARKER, JEFFERY L.
AU - PAUL, STEVEN M.
T1 - Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor.
JO - Science
JF - Science
Y1 - 1986/05/23/
VL - 232
IS - 4753
M3 - Article
SP - 1004
EP - 1007
SN - 00368075
AB - Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-5α-dihydroprogesterone and 3a,5a-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands ofthe -y-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10-7 and 10-5M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones to rapidly alter neuronal excitability and may provide a mechanism for the anesthetic and hypnotic actions of naturally occurring and synthetic anesthetic steroids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546984; MAJEWSKA, MARIA DOROTA 1 HARRISON, NEIL L. 2 SCHWARTZ, ROCHELLE D. 1 BARKER, JEFFERY L. 2 PAUL, STEVEN M. 1; Affiliation: 1: Sections on Molecular Pharmacology and Preclinical Studies, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892 2: Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/23/1986, Vol. 232 Issue 4753, p1004; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weinsier, Roland L.
AU - Boker, John R.
AU - Feldman, Elaine B.
AU - Read, Merrill S.
AU - Brooks, C. Michael
T1 - Nutrition knowledge of senior medical students: a collaborative study of southeastern medical schools.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/06//
VL - 43
IS - 6
M3 - Article
SP - 959
EP - 968
SN - 00029165
AB - The Southeastern Regional Medical-Nutrition Education Network (SERMEN) comprises 11 medical schools with varied nutrition training programs. A faculty representative from each school rated 41 topics in nutrition as to their importance for medical practice. From the seven topics unanimously chosen, a 90-item examination was prepared using the University of Alabama School of Medicine's Nutrition Test-Item Bank. Thirteen additional items surveyed student attitudes toward their nutrition training. Twenty-one percent of senior students from 10 SERMEN schools took the examination. Results showed significant variation in knowledge levels among the schools on the overall examination and on the seven topics. Eighty-five percent were dissatisfied with the quantity and 60% with the quality of their medical-nutrition education. Knowledge scores correlated with the students' assessments with r values of 0.28 and 0.35, respectively(p <0.001). Findings indicate significant variation in nutrition knowledge of US medical students. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Physiology
KW - Medical students
KW - Health occupations students
KW - Medical schools
KW - medical education
KW - Nutrition education
KW - nutrition teaching
N1 - Accession Number: 91253784; Weinsier, Roland L. 1; Boker, John R. 2; Feldman, Elaine B. 3; Read, Merrill S. 4; Brooks, C. Michael 2; Affiliations: 1: Department of Nutrition Sciences, University of Alabama, Birmingham; 2: Office of Educational Development, University of Alabama, Birmingham; 3: Nutrition Section of the Medical College of Georgia, Augusta, GA; 4: Clinical Nutrition and Early Development Branch, National Institute of Child Health and Human Development, Bethesda, MD; Issue Info: Jun1986, Vol. 43 Issue 6, p959; Thesaurus Term: Nutrition; Thesaurus Term: Physiology; Subject Term: Medical students; Subject Term: Health occupations students; Subject Term: Medical schools; Author-Supplied Keyword: medical education; Author-Supplied Keyword: Nutrition education; Author-Supplied Keyword: nutrition teaching; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shock, Nathan W.
T1 - THE DEVELOPMENT OF AGING.
JO - BioScience
JF - BioScience
Y1 - 1986/06//
VL - 36
IS - 6
M3 - Book Review
SP - 391
EP - 391
SN - 00063568
AB - Reviews the book "Molecular Basis of Aging," edited by A.K. Roy and B. Chatterjee.
KW - Aging
KW - Nonfiction
KW - Molecular Basis of Aging (Book)
N1 - Accession Number: 10106361; Shock, Nathan W. 1; Affiliations: 1: National Institute on Aging, Baltimore City Hospital, Baltimore, MD 21224; Issue Info: Jun86, Vol. 36 Issue 6, p391; Subject Term: Aging; Subject Term: Nonfiction; Reviews & Products: Molecular Basis of Aging (Book); Number of Pages: 2/3p; Document Type: Book Review; Full Text Word Count: 513
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Caughman, S. Wright
AU - Breathnach, Stephen M.
AU - Sharrow, Susan O.
AU - Stephany, David A.
AU - Katz, Stephen I.
T1 - Culture and Characterization of Murine Dendritic Thy-1+ Epidermal Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/06//
VL - 86
IS - 6
M3 - Article
SP - 615
EP - 624
SN - 0022202X
AB - Although numerous advances have been made in characterizing the phenotype, ontogeny, ultrastructure, and cyrochemistry of the murine Thy-1+ dendritic epidermal cell (Thy-1+ EC), elucidation of its functional qualities has been hampered by the difficulty in preparing pure populations of these cells. We therefore sought to obtain expanded, purified populations of Thy-1+ EC using culture techniques. Since Thy-1+ EC are bone marrow-derived, density gradient enriched populations of freshly harvested epidermal cells (FH-EC) were placed in culture under conditions known or suspected to promote mitogenesis among leukocyte subsets. FH-EC prepared from truncal skin of C3H/HeN mice (Thy-1.2+ ) were cultured at 37°C in 5% CO2 in complete medium (CM) of Eagle's Hanks' amino acid with 10% fetal calf serum, nutrients, and antibiotics at 106 FH-EC/well in 24-well culture plates. CM was supplemented with one or more of the following: concanavalin A (Con-A), interleukin-1 /epidermal cell-derived thymocyte-activating factor (IL-l/ETAF), IL-2, IL-3. γ interferon, indomethacin (IM), and anti-Thy-1.2 antibody. Media with appropriate supplements were changed every 2-3 days. Freshly isolated, enriched FH-EC contained 7-20% Thy-1+ EC (defined as brightly fluorescing cells readily distinguishable from weakly fluorescing keratinocytes), which also stained with antibodies directed against asialo GM1, Ly 5.1 , and vimentin but did not stain with antibodies to other T cell-, B cell- or macrophage phenotypic markers. Analysis of 10 separate cultures revealed a 3- to 10-fold expansion of nonkeratinocyte Thy-I ± cells after 21 ± 4 days in culture in CM supplemented with Con-A and IM, and 70-100% of viable cells after expansion were Thy- 1+. Phenotypic analysis of expanded cells revealed the emergence in 10 separate cultures of one two mutually exclusive distinct populations: one Thy- 1+, asialo GM1+, L3T4- (natural killer phenotype) and the other Thy- 1+, asialo GM1-, L3T4+ (T helper phenotype). Experiments designed to explain the emergence of an L3T4+ population suggest that phenotypic modulation occurred in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENDRITIC cells
KW - EPIDERMIS -- Diseases
KW - MOUSE leukemia viruses
KW - KERATINOCYTES
KW - PHENOTYPE
KW - DERMATOLOGY
N1 - Accession Number: 12275611; Caughman, S. Wright 1 Breathnach, Stephen M. 1 Sharrow, Susan O. 2 Stephany, David A. 2 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Immunology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jun86, Vol. 86 Issue 6, p615; Subject Term: DENDRITIC cells; Subject Term: EPIDERMIS -- Diseases; Subject Term: MOUSE leukemia viruses; Subject Term: KERATINOCYTES; Subject Term: PHENOTYPE; Subject Term: DERMATOLOGY; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1523-1747.ep12275611
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lamberg, Stanford I.
AU - Yuspa, Stuart H.
AU - Hascall, Vincent C.
T1 - Synthesis of Hyaluronic Acid Is Decreased and Synthesis of Proteoglycans Is Increased When Cultured Mouse Epidermal Cells Differentiate.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/06//
VL - 86
IS - 6
M3 - Article
SP - 659
EP - 667
SN - 0022202X
AB - New born mouse epidermal cells proliferate when cultured in 0.5 mM Ca++ medium and terminally differentiate when the Ca++ is increased to about 1.2 mM, the level found in most cell culture media. We found that hyaluronic acid and proteoglycans were synthesized by isolated cultured newborn mouse epidermal cells and that quantitative and qualitative changes in these macromolecules appeared when proliferating epidermal cultures were induced to differentiate by calcium. A major change that occurred with differentiation was a reduction in synthesis of hyaluronic acid while synthesis of proteoglycans and glycoproteins increased. The proteoglycans synthesized in these cultures were heparan sulfate-proteoglycan (90%) and chondroitin sulfate-proteoglycan (10%), regardless of the calcium level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYALURONIC acid
KW - MUCOPOLYSACCHARIDES
KW - PROTEOGLYCANS
KW - GLYCOPROTEINS
KW - EPIDERMIS
KW - DERMATOLOGY
N1 - Accession Number: 12275707; Lamberg, Stanford I. 1 Yuspa, Stuart H. 2 Hascall, Vincent C. 3; Affiliation: 1: Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, U.S.A. 2: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A. 3: Bone Research Branch, National Institute of Dental Research, Bethesda, Maryland. U.S.A.; Source Info: Jun86, Vol. 86 Issue 6, p659; Subject Term: HYALURONIC acid; Subject Term: MUCOPOLYSACCHARIDES; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: EPIDERMIS; Subject Term: DERMATOLOGY; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1523-1747.ep12275707
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr., Paul T.
T1 - Personality, coping, and coping effectiveness in an adult sample.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1986/06//
VL - 54
IS - 2
M3 - Article
SP - 385
PB - Wiley-Blackwell
SN - 00223506
AB - Two studies of coping among community-dwelling adults (N = 255, 151) were used to examine the influence of personalty on coping responses, the perceived effectiveness of coping mechanisms, and the effects of coping and personality on well-being. In both studies a wide range of potential stressors was examined, categorized as losses, threats, or challenges. The personality dimensions of neuroticism, extraversion, and openness to experience, as measured by both selfreports and spouse- and peer-ratings, were systematically related to coping mechanisms in both studies. There was general agreement across types of stressors on the use and perceived effectiveness of the 27 coping mechanisms, and individuals who used more effective ways of coping generally reported higher subsequent happiness and life satisfaction. However, personality variables are also known to be determinants of well-being, and the associations between coping and well-being were reduced when personality measures were partialled out. Some implications for the design and interpretation of coping effectiveness studies are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERSONALITY
KW - CONSCIOUSNESS
KW - PSYCHOLOGY
KW - ADJUSTMENT (Psychology)
KW - WELL-being
KW - HAPPINESS
KW - LIFE CYCLE: ADULTHOOD AND THE FAMILY
N1 - Accession Number: 8970678; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun86, Vol. 54 Issue 2, p385; Subject Term: PERSONALITY; Subject Term: CONSCIOUSNESS; Subject Term: PSYCHOLOGY; Subject Term: ADJUSTMENT (Psychology); Subject Term: WELL-being; Subject Term: HAPPINESS; Author-Supplied Keyword: LIFE CYCLE: ADULTHOOD AND THE FAMILY; Number of Pages: 21p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970678
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr., Paul T.
AU - Busch, Catherine M.
T1 - Evaluating comprehensiveness in personality systems: The California Q-Set and the five-factor model.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1986/06//
VL - 54
IS - 2
M3 - Article
SP - 430
PB - Wiley-Blackwell
SN - 00223506
AB - The analysis of natural language trait names and questionnaire scales has suggested that the five factors of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness constitute an adequate taxonomy of personality. An alterantive approach to comprehensive personality assessment based on clinical judgments is given by the California Q-Set (COS, Block, 1961). When self-Qsorts from 403 adult men and women were factored, the five factors closely resembled those found m adjectives, and showed convergent and discriminant validity against self-reports and peer- and spouse-ratings on measures of the fivefactor model Results were replicated when interviewer Q-sort ratings were examined for a subset of subjects. These findings strongly support the claim to comprehensiveness of the five-factor model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERSONALITY
KW - CONSCIOUSNESS
KW - PSYCHOLOGY
KW - PERSONALITY assessment
KW - QUESTIONNAIRES
KW - CALIFORNIA
KW - UNITED States
N1 - Accession Number: 8970694; McCrae, Robert R. 1 Costa Jr., Paul T. 1 Busch, Catherine M. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun86, Vol. 54 Issue 2, p430; Subject Term: PERSONALITY; Subject Term: CONSCIOUSNESS; Subject Term: PSYCHOLOGY; Subject Term: PERSONALITY assessment; Subject Term: QUESTIONNAIRES; Subject Term: CALIFORNIA; Subject Term: UNITED States; Number of Pages: 17p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970694
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, C. A. D.
AU - Rushton, P.
AU - Bray, C. M.
T1 - Polyadenylated RNA metabolism and loss of vigour and viability in germinating wheat embryos.
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1986/06//
VL - 67
IS - 2
M3 - Article
SP - 310
EP - 314
SN - 00319317
AB - The quiescent wheat (Triticum aestivum L. cv. Hobbit) embryo contains polyadenylated RNA species (polyA+ RNA, presumptive mRNA species) which are rapidly degraded upon water imbibition by the embryo even when the embryo has lost viability. The level of polyA+ RNA species in the quiescent embryo does not reflect the vigour or viability rating of the seed lot. Embryos which have lost viability appear to have lost the capacity for de novo transcription of poIyA+ RNA species during the hours following water imbibition by the embryo. Embryos from seed lots of differing vigour ratings can be distinguished by their very different patterns of poIyA+ RNA metabolism during germination at a sub-optimal temperature. In embryos of reduced vigour there is a delayed onset of degradation of polyA+ RNA species during germination at 10°C and a reduced rate of polyA+ RNA synthesis through the first 6 h of germination compared with these processes in high vigour embryos. However, at later germination stages embryos of reduced vigour synthesise polyA+ RNA species at rates similar to those found in high vigour embryos yet newly synthesised Poly+ RNA species accumulate in embryos of reduced vigour only to a level which is 50% of that found in high vigour embryos of comparable viability. Results suggest that additional lesions affecting the stability and/or turnover of the messenger ribonucleo-protein complex containing poIyA+RNA are present in embryos of reduced vigour at later stages of germination at a sub-optimal temperature. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESSENGER RNA
KW - METABOLISM
KW - NUCLEIC acids
KW - PLANT physiology
KW - PROTEIN synthesis
KW - BIOSYNTHESIS
KW - Protein biosynthesis.
N1 - Accession Number: 12909809; Smith, C. A. D. 1 Rushton, P. 2 Bray, C. M. 2; Affiliation: 1: Department of Health & Human Services, National Institute of Health, National Cancer Institute, Bethesda, MD 20205, U.S.A. 2: Department of Biochemistry, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.; Source Info: Jun86, Vol. 67 Issue 2, p310; Subject Term: MESSENGER RNA; Subject Term: METABOLISM; Subject Term: NUCLEIC acids; Subject Term: PLANT physiology; Subject Term: PROTEIN synthesis; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: Protein biosynthesis.; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1399-3054.ep12909809
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ISHII, SHUNSUKE
AU - KADONAGA, JAMES T.
AU - TJIAN, ROBERT
AU - BRADY, JOHN N.
AU - MERLINO, GLENN T.
AU - PASTAN, IRA
T1 - Binding of the Spl Transcription Factor by the Human Harvey rasl Proto-oncogene Promoter.
JO - Science
JF - Science
Y1 - 1986/06/13/
VL - 232
IS - 4756
M3 - Article
SP - 1410
EP - 1413
SN - 00368075
AB - Members of the ras gene family encode proteins that when overproduced or mutated can transform immortalized mammalian cells. It is therefore important to understand the mechanisms by which the ras genes are regulated. The promoter region of the human Harvey ras proto-oncogene c-Ha-rasl initiates RNA transcription at multiple sites and contains repeated copies of the hexanucleotide GGGCGG' nd its inverted complement CCGCCC, referred to as GC boxes. These GC boxes consist of sequences identical to those found in the SV40 early promoter, where the human cellular transcriptional factor Spl binds. Footprinting analysis with deoxyribonuclease I was used to show that Spl binds to six GC box sequences within the c-Ha-rasl promoter. An in vivo transfection assay showed competition between the 21-base pair repeats of the SV40 promoter and the c-Ha-rasl promoter for common regulatory factors. In this system the presence of Spl is ap,parently required for c-Ha-rasl transcription. Analysis of deletions of the c-Ha-rasl promoter region by means of a transient expression assay revealed that the three Spl binding sites closest to the RNA start sites were sufficient for full transcriptional activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546722; ISHII, SHUNSUKE 1 KADONAGA, JAMES T. 2 TJIAN, ROBERT 2 BRADY, JOHN N. 3 MERLINO, GLENN T. 1 PASTAN, IRA 1; Affiliation: 1: Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 2: Department of Biochemistry, University of California, Berkeley, CA 94720 3: Laboratory of Molecular Virology, Division of Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 6/13/1986, Vol. 232 Issue 4756, p1410; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DICKSON, ROBERT B.
AU - MCMANAWAY, MARY E.
AU - LIPPMAN, MARC E.
T1 - Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth.
JO - Science
JF - Science
Y1 - 1986/06/20/
VL - 232
IS - 4757
M3 - Article
SP - 1540
EP - 1543
SN - 00368075
AB - The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were suient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus pardally replacing estradiol. Growth factors may act as estrogen-induced "second messengers" in estrogen responsive growth of human breast cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546750; DICKSON, ROBERT B. 1 MCMANAWAY, MARY E. 1 LIPPMAN, MARC E. 1; Affiliation: 1: Medical Breast Cancer Section, Medicine Branch, National Cancer Institute, Bethcsda, MD 20892; Source Info: 6/20/1986, Vol. 232 Issue 4757, p1540; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HAHN, BEATRICE H.
AU - SHAW, GEORGE M.
AU - TAYLOR, MARIA E.
AU - REDFIELD, ROBERT R.
AU - MARKHAM, PHIL D.
AU - SALAHUDDIN, S. Z.
AU - WONG-STAAL, FLOSSIE
AU - GALLO, ROBERT C.
AU - PARKS, ELIZABETH S.
AU - PARKS, WADE P.
T1 - Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS.
JO - Science
JF - Science
Y1 - 1986/06/20/
VL - 232
IS - 4757
M3 - Article
SP - 1548
EP - 1553
SN - 00368075
AB - In a study of genetic variation in the AIDS virus, HTLV-III/LAV, sequential virus isolates from persistently infected individuals were examined by Southern blot genomic analysis, molecular doning, and nucleotide sequencing. Four to six virus isolates were obtained from each of three individuals over a 1-year or 2-year period. Changes were detected throughout the viral genomes and consisted of isolated and clustered nucleotide point mutations as well as short deletions or insertions. Results from genomic restriction mapping and nucleotide sequence comparisons indicated that viruses isolated sequentially had evolved in parallel from a common progenitor virus. The rate of evolution of HTLV-III/LAV was estimated to be at least 10-3 nucleotide substitutions per site per year for the env gene and 10-4 for thegag gene, values a millionfold greater than for most DNA genomes. Despite this relatively rapid rate of sequence divergence, virus isolates from any one patient were all much more related to each other than to viruses from other individuals. In view of the substantial heterogeneity among most independent HTLV-III/LAV isolates, the repeated isolation from a given individual of only highly related viruses raises the possibility that some type of interference mechanism may prevent simultaneous infection by more than one major genotypic form of the virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87546763; HAHN, BEATRICE H. 1 SHAW, GEORGE M. 1 TAYLOR, MARIA E. 1 REDFIELD, ROBERT R. 2 MARKHAM, PHIL D. 3 SALAHUDDIN, S. Z. 3 WONG-STAAL, FLOSSIE 3 GALLO, ROBERT C. 3 PARKS, ELIZABETH S. 4 PARKS, WADE P. 4; Affiliation: 1: Division of Hematology and Oncology, University of Alabama Medical Center, Birmingham, AL 35294 2: Department of Virus Diseases, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC 20307 3: Laboratory of Tumor Cell Biology, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205 4: Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101; Source Info: 6/20/1986, Vol. 232 Issue 4757, p1548; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nakao, Keiko
AU - Milazzo-Sayre, Laura J.
AU - Rosenstein, Marilyn J.
AU - Manderscheid, Ronald W.
T1 - Referral Patterns to and from Inpatient Psychiatric Services: A Social Network Approach.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/07//
VL - 76
IS - 7
M3 - Article
SP - 755
EP - 760
PB - American Public Health Association
SN - 00900036
AB - Abstract: Interorganizational linkages have assumed more import for mental health service systems during the past three decades because of increased levels of complexity in service delivery patterns. This analysis examines these linkages from a relational perspective, with network of patient referral patterns as the basic unit. Multidimensional scaling is employed to discern patterns of interorganizational linkages in national patient referral data collected by the National Institute of Mental Health m 1975 and 1980 for patient samples from inpatient psychiatric services of state and county mental hospitals, private psychiatric hospitals, and public and nonpublic general hospitals. The multidimensional scaling techniques distinguish two structural characteristics of the interorganizational linkages of psychiatric inpatient services--public vs private services, and drift over time in referral patterns. Public and private inpatient psychiatric services are differentiated principally in terms of ° of interaction with legal agencies and private practice psychiatrists. Chronological change in referral patterns is characterized principallly by changes in the ° of interaction with other inpatient or outpatient psychiatric services. Methodologically and theoretically, the techniques and findings described can enhance our understanding of interorganizational linkages and dynamics. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHIATRIC referral
KW - CONSULTATION-liaison psychiatry
KW - MEDICAL referral
KW - MENTAL health services
KW - MULTIDIMENSIONAL scaling
KW - PSYCHOLOGICAL tests
KW - PSYCHIATRISTS
KW - OUTPATIENT medical care
KW - UNITED States
KW - NATIONAL Institute of Mental Health (U.S.)
N1 - Accession Number: 4687181; Nakao, Keiko 1 Milazzo-Sayre, Laura J. 1 Rosenstein, Marilyn J. 1 Manderscheid, Ronald W. 2; Affiliation: 1: Chief, Survey and Reports Branch, DBE, National Institute of Mental Health, DHHS, PHS, Room 18C-07 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857 2: Department of Sociology, University of California, Los Angeles; Source Info: Jul1986, Vol. 76 Issue 7, p755; Subject Term: PSYCHIATRIC referral; Subject Term: CONSULTATION-liaison psychiatry; Subject Term: MEDICAL referral; Subject Term: MENTAL health services; Subject Term: MULTIDIMENSIONAL scaling; Subject Term: PSYCHOLOGICAL tests; Subject Term: PSYCHIATRISTS; Subject Term: OUTPATIENT medical care; Subject Term: UNITED States; Company/Entity: NATIONAL Institute of Mental Health (U.S.); NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simon, Jean
AU - Leroith, Derek
T1 - Insulin receptors of chicken liver and brain.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/07//7/1/86
VL - 158
IS - 1
M3 - Article
SP - 125
EP - 132
PB - Wiley-Blackwell
SN - 00142956
AB - Discusses results of a study characterizing the alpha and beta subunit properties of the insulin receptors of chicken liver and brain. Insulin potency ratios; Apparent binding affinity; Effect of neuraminidase on mobility of alpha subunit from liver; Best artificial substrate for phosphorylation; Molecular mass.
KW - INSULIN
KW - ALPHA adrenoceptors
KW - BETA adrenoceptors
KW - LIVER
KW - BRAIN
KW - NEURAMINIDASE
N1 - Accession Number: 12234053; Simon, Jean 1 Leroith, Derek 1; Affiliation: 1: Diabetes Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health; Source Info: 7/1/86, Vol. 158 Issue 1, p125; Subject Term: INSULIN; Subject Term: ALPHA adrenoceptors; Subject Term: BETA adrenoceptors; Subject Term: LIVER; Subject Term: BRAIN; Subject Term: NEURAMINIDASE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eun Sul Lee
AU - Forthofer, Ronald N.
AU - Holzer III, Charles E.
AU - Taube, Carl A.
T1 - Complex Survey Data Analysis: Estimation of Standard Errors Using Pseudostrata.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 1986/07//
VL - 14
IS - 2
M3 - Article
SP - 135
EP - 144
PB - IOS Press
SN - 07479662
AB - A proper analysis of data from complex sample surveys requires special consideration for estimating standard errors. Special techniques and software packages are available, including Taylor series linearization (delta method), balanced repeated replication, and jackknife. Before their use, it is often necessary to make certain modifications in original data structure, to conform to computing method requirements. The most common modification is to form pseudostrata by collapsing substrata or partitioning a string of geographic clusters. This paper examines the performance of the delta method when it is applied to a complex community survey data set in which sequentially drawn clusters of households are partitioned to form pseudostrata. Standard errors of rates, regression coefficients, and odds ratios are compared with those computed from the variation of replicates built into the sample design. The results demonstrate that an analysis of complex survey data should use an appropriate method for estimating standard errors, and that pseudostrata would produce reasonable estimates of standard errors for rates and regression coefficients, with mixed results for odds ratios. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - DEMOGRAPHIC surveys
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - COMPUTER software
KW - JACKKNIFE (Statistics)
KW - SOCIAL surveys
KW - SOCIAL science research
KW - UNITED States
N1 - Accession Number: 6641950; Eun Sul Lee 1; Forthofer, Ronald N. 1; Holzer III, Charles E. 2; Taube, Carl A. 3; Affiliations: 1: University of Texas Health Science Center, Houston; 2: University of Texas Medical Branch, Galveston; 3: National Institute of Mental Health; Issue Info: Jul86, Vol. 14 Issue 2, p135; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: DEMOGRAPHIC surveys; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: COMPUTER software; Subject Term: JACKKNIFE (Statistics); Subject Term: SOCIAL surveys; Subject Term: SOCIAL science research; Subject: UNITED States; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Shimada, Shinji
AU - Schwartz, Ronald H.
AU - Katz, Stephen I.
T1 - Development and Characterization of Trinitrophenyl-Specific L3T4+ T-Cell Clones.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/07//
VL - 87
IS - 1
M3 - Article
SP - 24
EP - 29
SN - 0022202X
AB - Two antigen-specific, L3T4+4, Lyt-2- T-cell clones have been developed from (C57BL/6 × C3H/HeN) F1 mice epicutaneously sensitized to trinitrochlorohenzene. Genetic mapping and antibody blocking studies demonstrated that both of these clones have specificity for trinitrophenyl in association with Eβk:Eαk or Eβb:Eαk Ia molecules. One of the clones (D-8) also recognizes nonhaptenated cells expressing Eβs: Eαk. These clones should provide useful tools for the assessment of the signals required for triggering immune responses to haptenated self antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - MICE
KW - NITROGLYCERIN
KW - GENE mapping
KW - LYMPHOCYTES
KW - GENETIC techniques
KW - IMMUNOGLOBULINS
N1 - Accession Number: 12523527; Shimada, Shinji 1 Schwartz, Ronald H. 2 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, Laboratory of Immunology, National Institute of Allergy, Bethesda, Maryland. U.S.A. 2: Infectious Diseases, National Institutes of Health, Bethesda, Maryland. U.S.A.; Source Info: Jul86, Vol. 87 Issue 1, p24; Subject Term: T cells; Subject Term: MICE; Subject Term: NITROGLYCERIN; Subject Term: GENE mapping; Subject Term: LYMPHOCYTES; Subject Term: GENETIC techniques; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12523527
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson Jr., Ray
T1 - A Triarchic Model of P300 Amplitude.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1986/07//
VL - 23
IS - 4
M3 - Article
SP - 367
EP - 384
SN - 00485772
AB - A model of P300 amplitude is proposed that reduces the many hypothetical constructs invoked to explain variations in P300 amplitude to three dimensions: 1) Subjective Probability, 2) Stimulus Meaning, and 3) Information Transmission. Evidence is presented to support the assertion that variables on the subjective probability and stimulus meaning dimensions have independent and additive contributions to overall P300 amplitude. The amplitude contributions of both of these dimensions, however, are modulated by a multiplicative relation with the proportion of transmitted stimulus information. Within each dimension, the fundamental experimental variables and their interrelations are specified. An example is presented to show how, by using an additive factors method, the respective amplitude effects of the probability and stimulus meaning dimensions can be separated. Supporting data are presented to show that the proposed model provides a reasonable and testable framework in which to conceptualize P300 results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHOPHYSIOLOGY
KW - ELECTROPHYSIOLOGY
KW - EVOKED potentials (Electrophysiology)
KW - LATENT variables
KW - NEUROLOGY
N1 - Accession Number: 11022771; Johnson Jr., Ray 1; Affiliation: 1: National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke, Medical Neurology Branch, Bethesda, Maryland.; Source Info: Jul1986, Vol. 23 Issue 4, p367; Subject Term: PSYCHOPHYSIOLOGY; Subject Term: ELECTROPHYSIOLOGY; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: LATENT variables; Subject Term: NEUROLOGY; Number of Pages: 18p; Document Type: Article
L3 - 10.1111/1469-8986.ep11022771
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Djeu, Julie Y.
AU - Kasahara, T.
AU - Balow, J. E.
AU - Tsokos, G. C.
T1 - Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1986/08//
VL - 65
IS - 2
M3 - Article
SP - 279
EP - 285
PB - Wiley-Blackwell
SN - 00099104
AB - The lymphokine, interleukin 2 (IL-2), is an important modulator of cell-mediated immune (CMI) responses. We report here the detection of an inhibitor of IL-2 in normal sera by measuring the inhibition of thymidine incorporation in IL-2 dependent murine CTLL cells. The inhibitor, partially purified by Sephacryl S-200 gel filtration, eluted with the 60,000-70,000 mol. wt fraction. The factor was destroyed at 56 °C for 30 min and did not bind to Protein A Sepharose, suggesting that it is not an immunoglobulin G. Of 26 normal sera tested, 23 had significant levels of the inhibitor. Since connective tissue diseases are often associated with deficient CMI responses, we examined the levels of IL-2 inhibitor in 26 systemic lupus erythematosus (SLE) and 22 rheumatoid arthritis (RA) patients. Only 8 SLE and 12 RA patients had normal levels of the inhibitor. Of the 18 SLE patients with low or undetectable levels, 15 had clinically defined active disease and of the eight with normal levels, three had active disease. The decrease In the IL-2 inhibitor level did not correlate either with steroid or cyctophosphamide treatment or with serum levels of DNA binding and C3. These data suggest that the function of the inhibitor is to control IL-2 activity under normal conditions. Decreased levels of the IL-2 inhibitor in these patients might be explained either as a reduced requirement of this regulatory protein secondary to decreased IL-2 production or a defect of the cells responsible for the production of both IL-2 and its inhibitor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-2
KW - AUTOIMMUNE diseases
KW - SYSTEMIC lupus erythematosus
KW - RHEUMATOID arthritis
KW - BLOOD plasma
KW - PATIENTS
KW - cell-mediated
KW - immune responses
KW - interleukin 2 inhibitor
KW - rheumatoid arthritis
KW - Systemic lupus erythematosus
N1 - Accession Number: 16099087; Djeu, Julie Y. 1 Kasahara, T. 1 Balow, J. E. 2 Tsokos, G. C. 2; Affiliation: 1: Department of Microbiology, University of Southern Florida, Tampa, Florida. 2: Kidney Disease Section,National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. USA.; Source Info: Aug1986, Vol. 65 Issue 2, p279; Subject Term: INTERLEUKIN-2; Subject Term: AUTOIMMUNE diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: RHEUMATOID arthritis; Subject Term: BLOOD plasma; Subject Term: PATIENTS; Author-Supplied Keyword: cell-mediated; Author-Supplied Keyword: immune responses; Author-Supplied Keyword: interleukin 2 inhibitor; Author-Supplied Keyword: rheumatoid arthritis; Author-Supplied Keyword: Systemic lupus erythematosus; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rasinowitz, Ruth
AU - Pescovitz, M. D.
AU - Sachs, D. H.
T1 - Anti-idiotype to monoclonal anti-swine SLA antibody detects a common idiotype shared by mouse anti-SLA sera and elicits an anti-SLA activity.
JO - Immunology
JF - Immunology
Y1 - 1986/08//
VL - 58
IS - 4
M3 - Article
SP - 607
EP - 613
PB - Wiley-Blackwell
SN - 00192805
AB - Heterologous anti-idiotypic reagents have been prepared against a BALB/c anti-swine MHC (SLAd) monoclonal antibody (74-11-10) in order to test for possible interspecies idiotypic cross-reactions of anti-MHC antibodies. Using these reagents to examine xenoantisera produced in BALH/c mice immunized with swine SLAdd peripheral blood lymphocytes, all animals tested were found to express detectable levels of the 74-11-10 idiotype (Id). The Id could also be detected in one out of five BALB/c mice immunized with swine SLAcc PBL. Swine anti-SLAdd alloantibodies were also tested, but failed to show detectable levels of the 74-11-10 Id. The in vivo administration of anti-idiotypic reagents to BALI/c mice induced detectable levels of 74-11-10 Id positive antibodies that bound specifically to SLAdd PHL. Similar treatment of SLAgg swine (recombinant swine expressing the class I MHC molecules of c) with anti-idiotypic antibodies failed to induce anti-SLAd antibody activity. These results thus indicate that 74-11-10 represents a shared idiotype of BA LB/c anti-SLAdd antibodies. The presence of 74-11-10 Id in one mouse immunized with SLA∞ PBL suggests that the failure of pigs to express the 74-11-10 Id following treatment with anti-idiotypic antibodies may be the result of tolerance rather than absence of the relevant variable region gene(s). [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - ANTI-idiotypic antibodies
KW - SWINE
KW - MICE
KW - IMMUNIZATION
KW - IMMUNOGLOBULINS
N1 - Accession Number: 14006879; Rasinowitz, Ruth 1 Pescovitz, M. D. 1 Sachs, D. H. 1; Affiliation: 1: Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug86, Vol. 58 Issue 4, p607; Subject Term: MONOCLONAL antibodies; Subject Term: ANTI-idiotypic antibodies; Subject Term: SWINE; Subject Term: MICE; Subject Term: IMMUNIZATION; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanley, John R.
AU - Klaus-Kovtun, Vera
AU - Sampaio, Sebastiao A. P.
T1 - Antigenic Specificity of Fogo Selvagem Autoantibodies Is Similar to North American Pemphigus Foliaceus and Distinct from Pemphigus Vulgaris Autoantibodies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/08//
VL - 87
IS - 2
M3 - Article
SP - 197
EP - 201
SN - 0022202X
AB - Fogo selvagem (PS) is clinically, histologically, and immunopathologically similar to sporadic pemphigus foliaceus (PE, as seen in North America and Europe), although the epidemiology of these 2 diseases differs markedly. It has been proposed that FS is identical to PF but, for some reason, occurs in an endemic focus in central Brazil. If this hypothesis is correct, the autoantibodies in FS and PF should have similar antigenic specificities. We studied sera from 13 patients with FS from central Brazil, and compared them with 20 sera from patients with PF from the United States. All these sera had circulating antibodies that bound the cell surface of epithelial cells in identical patterns by indirect immunofluorescence on monkey esophagus or normal human skin. In immunoprecipitation studies none of the 13 FS sera precipitated the pemphigus vulgaris (PV) antigen from radiolabeled extracts of cultured human keratino- cytes. This is similar to the findings with PF sera of which 19 of 20 sera did not react with PV antigen, but in sharp contrast to the results with PV sera which, as previously reported, all immunoprecipitate the PV antigen. Immunoblotting performed on extracts of normal human epidermis demonstrated that 7 of 20 PF sera specifically and intensely bound an approximately 160 kD polypeptide, previously identified as desmoglein I, a desmosomal glycoprotein. Similarly, 3 of 13 FS sera specifically bound a 160 kD polypeptide. Thirteen normal sera from North America, 8 normal and disease control sera from central Brazil, 11 PV sera, and 12 bullous pemphigoid sera did not specifically bind this polypeptide. Two-dimensional gel electrophoresis confirmed that the 160 kD polypeptides identified by the subgroup of PF and FS sera were identical. These studies demonstrate that, although the exact molecular specificities of the majority of PF and FS sera remain to be determined, FS autoantibodies do not bind the PV antigen and a subgroup of FS autoantibodies have molecular specificity identical to that of a subgroup of PF auto-antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEMPHIGUS
KW - ANTIGENS
KW - IMMUNOSPECIFICITY
KW - AUTOANTIBODIES -- Analysis
KW - EPIDEMIOLOGY
KW - NORTH America
KW - EUROPE
N1 - Accession Number: 12695334; Stanley, John R. 1 Klaus-Kovtun, Vera 1 Sampaio, Sebastiao A. P. 2; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Division of Dermatology, São Paulo University, São Paulo, Brazil.; Source Info: Aug86, Vol. 87 Issue 2, p197; Subject Term: PEMPHIGUS; Subject Term: ANTIGENS; Subject Term: IMMUNOSPECIFICITY; Subject Term: AUTOANTIBODIES -- Analysis; Subject Term: EPIDEMIOLOGY; Subject Term: NORTH America; Subject Term: EUROPE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12695334
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DiGiovanna, John J.
AU - Fletcher, R. Theodore
AU - Chader, Gerald J.
T1 - REPLY.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/08//
VL - 87
IS - 2
M3 - Article
SP - 296
EP - 296
SN - 0022202X
AB - Presents a response by authors to a letter to the editor regarding their article on measurement of cellular retinol-binding protein in human dermis, published in the August 1986 issue of the "Journal of Investigative Dermatology."
KW - DERMIS
KW - LETTERS to the editor
N1 - Accession Number: 12696814; DiGiovanna, John J. 1 Fletcher, R. Theodore 1 Chader, Gerald J. 1; Affiliation: 1: National Institutes of Health Bethesda, Maryland; Source Info: Aug86, Vol. 87 Issue 2, p296; Subject Term: DERMIS; Subject Term: LETTERS to the editor; Number of Pages: 1/2p; Document Type: Article
L3 - 10.1111/1523-1747.ep12696814
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hofferth, Sandra L.
T1 - Response to a Comment by Bumpass on "Updating Children's Life Course.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1986/08//
VL - 48
IS - 3
M3 - Article
SP - 680
EP - 682
SN - 00222445
AB - This section presents a rely to a comment on the article "Updating Children's Life Course." The primary reason why numbers are different is that very different things are being estimated. In addition, although everybody wants the bottom line, obtaining that number is very difficult. The author of the article has done a real service with his two very careful studies of the experience of children, the first in 1979 and the second in 1984. All studies are restricted by the fact that the most recent cohorts of children have not experienced their full childhood, and therefore, does not know what their experience will be.
KW - CHILD rearing
KW - EXPERIENCE
KW - COGNITION
KW - HUMAN life cycle
KW - CHILD development
KW - CHILD psychology
KW - CHILD care
N1 - Accession Number: 5273526; Hofferth, Sandra L. 1; Affiliation: 1: Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute of Child Health and Human Development, 7910 Woodmont Ave., Room 7C25, Bethesda, MD 20892; Source Info: Aug86, Vol. 48 Issue 3, p680; Subject Term: CHILD rearing; Subject Term: EXPERIENCE; Subject Term: COGNITION; Subject Term: HUMAN life cycle; Subject Term: CHILD development; Subject Term: CHILD psychology; Subject Term: CHILD care; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SPORN, MICHAEL B.
AU - ROBERTS, ANITA B.
AU - WAKEFIELD, LALAGE M.
AU - ASSOIAN, RICHARD K.
T1 - Transforming Growth Factor-β Biological Function and Chemical Structure.
JO - Science
JF - Science
Y1 - 1986/08//8/1/1986
VL - 233
IS - 4763
M3 - Article
SP - 532
EP - 534
SN - 00368075
AB - Transforming growth factor-β (TGF-β) is a multifimctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-β and essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519496; SPORN, MICHAEL B. 1 ROBERTS, ANITA B. 1 WAKEFIELD, LALAGE M. 1 ASSOIAN, RICHARD K. 1; Affiliation: 1: Laboratory of Chemoprevention, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/1/1986, Vol. 233 Issue 4763, p532; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JAYE, MICHAEL
AU - HOWK, RICHARD
AU - BURGESS, WILSON
AU - RICCA, GEORGE A.
AU - ING-MING CHIU
AU - RAVERA, MARK W.
AU - O'BRIEN, STEPHEN J.
AU - MODI, WILLIAM S.
AU - MACIAG, THOMAS
AU - DROHAN, WILLIAM N.
T1 - Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization.
JO - Science
JF - Science
Y1 - 1986/08//8/1/1986
VL - 233
IS - 4763
M3 - Article
SP - 541
EP - 545
SN - 00368075
AB - Several of the endothelial cell polypeptide mitogens that have been described probably play a role in blood vessel homeostasis. Two overlapping complementary DNA clones encoding human endothelial cell growth factor (ECGF) were isolated from a human brain stem complementary DNA library. Southern blot analysis suggested that there is a single copy of the ECGF gene and that it maps to human chromosome 5 at bands 5q31.3 to 33.2. A 4.8-kilobase messenger RNA was present in human brain stem messenger RNA. The complete amino acid sequence of human ECGF was deduced from the nucleic acid sequence ofthese dones; it encompasses all the well-characterized acidic endothelial cell polypeptide mitogens described by several laboratories. The ECGF-encoding open reading frame is flanked by tranislation stop codons and provides no signal peptide or internal hydrophobic domain for the secretion ofECGF. This property is shared by human interleukin-1, which is approximately 30 percent homologous to ECGF. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519523; JAYE, MICHAEL 1 HOWK, RICHARD 2 BURGESS, WILSON 2 RICCA, GEORGE A. 1 ING-MING CHIU 1 RAVERA, MARK W. 1 O'BRIEN, STEPHEN J. 3 MODI, WILLIAM S. 3 MACIAG, THOMAS 2 DROHAN, WILLIAM N. 1; Affiliation: 1: Molecular Biology Division, Meloy Laboratories, Springfield, VA 22151 2: Department of Cell Biology, Biotechnology Research Center, Rockville, MD 208502 3: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research Center, Frederick, MD 21701; Source Info: 8/1/1986, Vol. 233 Issue 4763, p541; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NORDAN, RICHARD P.
AU - POTTER, MICHAEL
T1 - A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro.
JO - Science
JF - Science
Y1 - 1986/08//8/1/1986
VL - 233
IS - 4763
M3 - Article
SP - 566
EP - 569
SN - 00368075
AB - Plasmacytoma (PCT) cell lines dependent for proliferation and survival on a factor elaborated by the murine macrophage cell line, P388D1, were established in vitro. Adherent peritoneal cells induced by pristane produced 50-fold greater amounts of this activity in vitro than did resident cells. The molecules responsible for plasmacytoma growth were distinct from a number of characterized factors including interleukin- 1, -2, and -3, macrophage colony-stntilating factor, B-cell stimulatory factor-I, B-cell growth factor II, epidermal growth factor, transforming growth factor-β, and γ- and β-interferon, none of which were able to support the growth of the factordependent PCT cell lines. These results suggest that PCT growth factor may be a novel factor that has not been previously characterized and, further, that its production is associated with the pristane-induced, chronic peritoneal inflammatory response that precedes plasmacytoma formation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519503; NORDAN, RICHARD P. 1 POTTER, MICHAEL 1; Affiliation: 1: Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/1/1986, Vol. 233 Issue 4763, p566; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - OZAWA, KEIYA
AU - KURTZMAN, GARY
AU - YOUNG, NEAL
T1 - Replication of the B19 Parvovirus in Human Bone Marrow Cell Cultures.
JO - Science
JF - Science
Y1 - 1986/08/22/
VL - 233
IS - 4766
M3 - Article
SP - 883
EP - 886
SN - 00368075
AB - The B19 parvovnrus is responsible for at least three human diseases. The virus was successfillly propagated in suspension cultures of human erythroid bone marrow from patients with hemolytic anemias; release of newly synthesized virus into the supernatants of infected cultures was observed. This culture system allowed study at a molecular level of events associated with the B19 life cycle. The B19 parvovirus replicated through high molecular weight intermediate forms, linked through a terminal hairpin structure. B19 replication in vitro was highly dependent on the erythropoietic content of cultures and on addition of the hormone erythropoietin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477664; OZAWA, KEIYA 1 KURTZMAN, GARY 1 YOUNG, NEAL 1; Affiliation: 1: Cell Biology Section, Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892; Source Info: 8/22/1986, Vol. 233 Issue 4766, p883; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 107000728
T1 - Health promotion and the elderly: why do it and where does it lead? Position paper.
AU - Williams TF
Y1 - 1986/08/25/
N1 - Accession Number: 107000728. Language: English. Entry Date: 20010209. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128.
KW - Health Services for the Aged -- Trends
KW - Health Policy -- Trends
KW - Health Promotion -- Trends -- In Old Age
KW - Health Behavior -- In Old Age
KW - Aged
SP - 257
EP - 262
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 7
IS - 2
PB - Taylor & Francis Ltd
SN - 0162-1424
AD - Director, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 31, 2C-02, Bethesda, Maryland 20205
U2 - PMID: 10280225.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Longo, Dan L.
T1 - ABC of Nutrition.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/09//
VL - 44
IS - 3
M3 - Book Review
SP - 431
EP - 432
SN - 00029165
KW - Nutrition
KW - Nonfiction
KW - Truswell, A. Stewart
KW - ABC of Nutrition (Book)
N1 - Accession Number: 91271446; Longo, Dan L. 1; Affiliations: 1: National Cancer Institute, Biological Response Modifiers Program, Frederick Cancer Research Facility, Building 567, Room 129, Frederick, MD 21701; Issue Info: Sep1986, Vol. 44 Issue 3, p431; Thesaurus Term: Nutrition; Subject Term: Nonfiction; Reviews & Products: ABC of Nutrition (Book); People: Truswell, A. Stewart; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Henderson, D. K.
AU - Kan, Virginia L.
AU - Bennett, J. E.
T1 - Tolerance to cryptococcal polysaccharide in cured cryptococcosis patients: failure of antibody secretion in vitro.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1986/09//
VL - 65
IS - 3
M3 - Article
SP - 639
EP - 646
PB - Wiley-Blackwell
SN - 00099104
AB - Ten patients cured of cryptococcosis and 14 normal volunteers were immunized with subcutaneous injections of cryptococcal polysaccharide (CPS). Peripheral mononuclear cells cultured from the volunteers 7 days post-immunization secreted significant amounts of 1gM. lgA and IgG antibody to CPS in vitro. In cell cultures obtained 7 days alter immunization of patients, nine of 10 had neither 1gM nor lgG antibody response to CPS. and eight lacked anti-CPS IgA. Depletion of T lymphocytes from patients cell cultures did not promote specific antibody secretion to CPS by B cells. The intense, prolonged antigenaemia with CPS that accompanies cryptococcosis may he responsible for the failure of cured patients to have circulating anti-CPS-secreting cells after immunization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - TORULOSIS
KW - CELL culture
KW - LEUCOCYTES
KW - T cells
KW - BIOLOGICAL transport
KW - cryptococcal polysaccharide
KW - immunization tolerance
KW - in vitro antibody production
N1 - Accession Number: 16169116; Henderson, D. K. 1,2 Kan, Virginia L. 2 Bennett, J. E. 2; Affiliation: 1: Hospital Epidemiology Service, National Institutes of Health, Clinical Center, Bethesda, MD. 2: Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy, Infections Diseases, Bcthesda, MD, USA.; Source Info: Sep1986, Vol. 65 Issue 3, p639; Subject Term: POLYSACCHARIDES; Subject Term: TORULOSIS; Subject Term: CELL culture; Subject Term: LEUCOCYTES; Subject Term: T cells; Subject Term: BIOLOGICAL transport; Author-Supplied Keyword: cryptococcal polysaccharide; Author-Supplied Keyword: immunization tolerance; Author-Supplied Keyword: in vitro antibody production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fleg, Jerome L.
AU - Gerstenblith, Gary
T1 - CHF: Reflections on current management of the older patient.
JO - Geriatrics
JF - Geriatrics
Y1 - 1986/09//
VL - 41
IS - 9
M3 - Article
SP - 71
EP - 81
SN - 0016867X
N1 - Accession Number: 17360843; Fleg, Jerome L. 1; Gerstenblith, Gary 2; Source Information: Sep1986, Vol. 41 Issue 9, p71; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 3440
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Zaslow, Martha
AU - Pedersen, Frank
AU - Suwalsky, Joan
AU - Rabinovich, Beth
AU - Cain, Richard
T1 - Fathering During the Infancy Period: Implications of the Mother's Employment Role.
JO - Infant Mental Health Journal
JF - Infant Mental Health Journal
Y1 - 1986///Fall86
VL - 7
IS - 3
M3 - Article
SP - 225
EP - 234
PB - John Wiley & Sons, Inc.
SN - 01639641
AB - This study addressed fathers' satisfaction with their wives' employment role and fathers' participation in child care and household tasks in a middle-class sample of families with first-born infants in which the mother was either employed or a homemaker. Observations of mother, father, and infant were carried out in the home on weekday evenings when the infants were 12 months old, and parent interviews were carried out after the completion of the observations. On interview measures, fathers with homemaker wives tended to report greater satisfaction with their wives' employment role than did fathers whose wives were employed. In addition, fathers with employed wives, but not those with homemaker wives, reported that they were participating more in child care and household tasks as a result of their wives' employment role. On home observation measures, fathers with employed wives were found to engage in somewhat less Distal Interaction with their infants, but the two groups did not differ with regard to Proximal, Complex Social, or Caregiving Interactions. The results indicate the need to give special consideration to the infancy period when one is examining both paternal endorsement of maternal employment and the father's participation with children in light of the mother's employment role. [ABSTRACT FROM AUTHOR]
AB - Copyright of Infant Mental Health Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FATHERS
KW - PARENTING
KW - WIVES
KW - EMPLOYMENT (Economic theory)
KW - MARRIED women -- Employment
KW - CHILD care
KW - CHILD rearing
KW - HOUSEHOLDS
KW - PARENT & child
KW - INFANTS
KW - PARENTHOOD
N1 - Accession Number: 12035160; Zaslow, Martha 1 Pedersen, Frank 1 Suwalsky, Joan 1 Rabinovich, Beth 1 Cain, Richard 1; Affiliation: 1: National Institute of Child Health and Human Development; Source Info: Fall86, Vol. 7 Issue 3, p225; Subject Term: FATHERS; Subject Term: PARENTING; Subject Term: WIVES; Subject Term: EMPLOYMENT (Economic theory); Subject Term: MARRIED women -- Employment; Subject Term: CHILD care; Subject Term: CHILD rearing; Subject Term: HOUSEHOLDS; Subject Term: PARENT & child; Subject Term: INFANTS; Subject Term: PARENTHOOD; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rapoport, Judith L.
AU - Donnelly, Maureen
AU - Zametkin, Alan
AU - Carrougher, John
T1 - 'SITUATIONAL HYPERACTIVITY' IN A U.S. CLINICAL SETTING.
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1986/09//
VL - 27
IS - 5
M3 - Article
SP - 639
EP - 646
SN - 00219630
AB - The article focuses on childhood hyperactivity, a major focus of research and clinical attention in the U.S. for the past 25 years. Eight of the 69 males who referred to a Hyperactivity Clinic for participation in psychopharmacological trials were not rated hyperactive by their primary caretaker on a parent symptom questionnaire. In comparison to eight boys for whom both parent and teacher ratings of hyperactivity were high, the group differed only in caretaker status. Situational children were less likely to be living with both biological parents. The findings suggest that at least in clinical settings, a distinction between situational and pervasive hyperactivity reflects caretaker status or attitude and not characteristics of the child.
KW - CHILD psychology
KW - HYPERACTIVE children
KW - PSYCHOLOGY
KW - PSYCHOPHARMACOLOGY consultation
KW - GUARDIAN & ward
KW - FAMILIES
KW - UNITED States
N1 - Accession Number: 11908069; Rapoport, Judith L. 1 Donnelly, Maureen 1 Zametkin, Alan 1 Carrougher, John 2; Affiliation: 1: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, U.S.A. 2: Uniformed Services School of Health Sciences, Bethesda, Maryland, U.S.A.; Source Info: Sep1986, Vol. 27 Issue 5, p639; Subject Term: CHILD psychology; Subject Term: HYPERACTIVE children; Subject Term: PSYCHOLOGY; Subject Term: PSYCHOPHARMACOLOGY consultation; Subject Term: GUARDIAN & ward; Subject Term: FAMILIES; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1469-7610.ep11908069
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sigman, Marian
AU - Mundy, Peter
AU - Sherman, Tracy
AU - Ungerer, Judy
T1 - SOCIAL INTERACTIONS OF AUTISTIC, MENTALLY RETARDED AND NORMAL CHILDREN AND THEIR CAREGIVERS.
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1986/09//
VL - 27
IS - 5
M3 - Article
SP - 647
EP - 636
SN - 00219630
AB - Social interactions of young autistic children and their caregivers were contrasted to interactions involving normal and mentally retarded controls. The autistic children displayed a much lower frequency of attention sharing behaviors, such as pointing to or showing objects. Alternatively, the autistic children directed as much looking, vocalizing and proximity behaviors toward their caregivers as did the other groups. Thus, although the autistic children did not show a clear lack of responsiveness to their caregivers, they did display a significant deficit in indicating behaviors during child-caregiver interaction.
KW - SOCIAL interaction
KW - AUTISTIC children
KW - CAREGIVERS
KW - CHILDREN with mental disabilities
KW - DEVELOPMENTALLY disabled children
KW - CHILD psychology
N1 - Accession Number: 11908133; Sigman, Marian Mundy, Peter Sherman, Tracy 1 Ungerer, Judy 2; Affiliation: 1: Laboratory of Developmental Psychology, National Institute of Mental Health, Washington DC, U.S.A. 2: Department of Psychology, Macquarie University, New South Wales, Australia.; Source Info: Sep1986, Vol. 27 Issue 5, p647; Subject Term: SOCIAL interaction; Subject Term: AUTISTIC children; Subject Term: CAREGIVERS; Subject Term: CHILDREN with mental disabilities; Subject Term: DEVELOPMENTALLY disabled children; Subject Term: CHILD psychology; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-7610.ep11908133
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mundy, Peter
AU - Sigman, Marian
AU - Ungerer, Judy
AU - Sherman, Tracy
T1 - DEFINING THE SOCIAL DEFICITS OF AUTISM: THE CONTRIBUTION OF NON-VERBAL COMMUNICATION MEASURES.
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1986/09//
VL - 27
IS - 5
M3 - Article
SP - 657
EP - 669
SN - 00219630
AB - In this article young autistic children were compared to normal and control samples on measures of non-verbal communication skills and object play skills. Deficits in non-verbal communications indicating behaviors best discriminated the children diagnosed as autistic from the other groups. Although the autistic children also exhibited deficits in object play behavior, these deficits did not add appreciably to the discriminant function based on the non-verbal communication behaviors. These results suggest that a deficit in the development of non-verbal indicating behaviors is a significant characteristic of young children who receive the diagnosis of autism.
KW - AUTISM
KW - DIAGNOSIS
KW - AUTISTIC children
KW - NONVERBAL communication
KW - CHILD psychology -- Research
KW - MENTALLY ill children
KW - SOCIAL interaction
N1 - Accession Number: 11908196; Mundy, Peter Sigman, Marian Ungerer, Judy 1 Sherman, Tracy 2; Affiliation: 1: Department of Psychology, Macquarie University, New South Wales, Australia. 2: Laboratory of Developmental Psychology, National Institute of Mental Health, Washington DC, U.S.A.; Source Info: Sep1986, Vol. 27 Issue 5, p657; Subject Term: AUTISM; Subject Term: DIAGNOSIS; Subject Term: AUTISTIC children; Subject Term: NONVERBAL communication; Subject Term: CHILD psychology -- Research; Subject Term: MENTALLY ill children; Subject Term: SOCIAL interaction; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1469-7610.ep11908196
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rogan, Walter J.
T1 - Comment.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1986/09//
VL - 81
IS - 395
M3 - Article
SP - 602
SN - 01621459
AB - The article comments on childhood leukemia incidence in Woburn, Massachusetts. The Woburn study is one of the few that has shown some disturbance in health of the neighborhood residents. Data for these studies are of three sorts: exposure, outcome, and nuisance variables or potential confounders. The usual confounders, like the usual suspects, can be identified and rounded up. Outcome variables are the illnesses and conditions that the author hopes to attribute to chemical exposures. The major one, childhood leukemia, is ascertained well, and people need have no suspicion that cases either escaped detection or that some cases really have something else. For practical purposes, perinatal deaths are also ascertained fully and remembered well. Amblyopia, impaired vision and strabismus, squint, sometimes including crossed eyes, are heavily dependent for their reporting on degree to which the parents are concerned. Down's syndrome should be reported well, but the significance of this finding rests on three cases in the high exposed group, and so would appear susceptible to chance.
KW - HAZARDOUS wastes
KW - LEUKEMIA
KW - SOLVENTS
KW - JUVENILE diseases
KW - PERINATAL death
KW - HEALTH
KW - VISION disorders
KW - WOBURN (Mass.)
KW - MASSACHUSETTS
KW - UNITED States
N1 - Accession Number: 4626933; Rogan, Walter J. 1; Affiliations: 1: Medical Officer, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep86, Vol. 81 Issue 395, p602; Thesaurus Term: HAZARDOUS wastes; Subject Term: LEUKEMIA; Subject Term: SOLVENTS; Subject Term: JUVENILE diseases; Subject Term: PERINATAL death; Subject Term: HEALTH; Subject Term: VISION disorders; Subject: WOBURN (Mass.); Subject: MASSACHUSETTS; Subject: UNITED States; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Zahn, Theodore P.
AU - Schooler, Carmi
AU - Murphy, Dennis L.
T1 - Autonomic Correlates of Sensation Seeking and Monoamine Oxidase Activity: Using Confirmatory Factor Analysis on Psychophysiological Data.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1986/09//
VL - 23
IS - 5
M3 - Article
SP - 521
EP - 531
SN - 00485772
AB - A negative relationship between platelet monoamine oxidase (MAO) activity and Sensation Seeking (SS) has been reported in several studies. This study evaluates the possible contribution of autonomic nervous system (ANS) activity to this relationship. Additionally, confirmatory factor analysis was used to create models of ANS concepts from a larger number of psychophysiological variables. Skin conductance (SC) and heart rate (HR) were recorded from 46 men and 49 women during a two-session protocol that included rest periods, a balloon stress, a series of tones, and two tasks: two-flash threshold and tachistoscopic recognition. Results showed that the best-fitting models for both rest and task periods included concepts of SC base levels ("arousal"), SC Lability, and HR, and were quite similar for men and women. MAO activity correlated positively with SC concepts, most strongly for women. Women showed negative relationships between sensation seeking and both SC arousal and HR concepts. In contrast, men showed evidence of positive relationships between SC concepts and an active life style. The sex differences and response specificity in these relationships make it unlikely that ANS activity mediates the negative MAO-SS relationship. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOAMINE oxidase
KW - BLOOD platelets
KW - SENSATION seeking
KW - AUTONOMIC nervous system
KW - FACTOR analysis
KW - HEART beat
N1 - Accession Number: 11026101; Zahn, Theodore P. 1,2 Schooler, Carmi 1 Murphy, Dennis L. 1; Affiliation: 1: National Institute of Mental Health. 2: Laboratory of Psychology and Psychopathology, Bldg. 10, Rm. 4C110, NIH, Bethesda, MD 20892.; Source Info: Sep1986, Vol. 23 Issue 5, p521; Subject Term: MONOAMINE oxidase; Subject Term: BLOOD platelets; Subject Term: SENSATION seeking; Subject Term: AUTONOMIC nervous system; Subject Term: FACTOR analysis; Subject Term: HEART beat; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1469-8986.ep11026101
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaye, Walter H.
AU - Gwirtsman, Harry E.
AU - Obarzanek, Eva
AU - George, Ted
AU - Jimerson, David C.
AU - Ebert, Michael H.
T1 - Caloric intake necessary for weight maintenance in anorexia nervosa: nonbulimics require greater caloric intake than bulimics.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/10//
VL - 44
IS - 4
M3 - Article
SP - 435
EP - 443
SN - 00029165
AB - In the past decade, patients with anorexia nervosa have been subdivided by the presence or absence of bingeing-and-purging behavior. Psychologic, physiologic, and premorbid weight differences have also been discovered between these subgroups. We now report that nonbulimic anorectics required 30-50% more caloric intake than bulimic anorectics to maintain a stable weight. This difference in caloric intake was independent of phase of illness; it was present at low weight and at intervals after weight restoration. Subjects were closely supervised on an inpatient hospital ward ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org ajcn.nutrition.org so that they could not binge or purge. Motor activity did not appear to explain these alterations in caloric requirements. Such differences in caloric intake could be trait related or a consequence of many years of starving or bingeing behavior. These findings are clinically relevant for advising eating disorder patients of caloric requirements necessary to maintain a normal weight. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anorexia nervosa
KW - Body weight
KW - Eating disorders
KW - Food -- Caloric content
KW - Body mass index
N1 - Accession Number: 91251607; Kaye, Walter H. 1; Gwirtsman, Harry E. 2; Obarzanek, Eva 2; George, Ted 2; Jimerson, David C. 2; Ebert, Michael H. 3; Affiliations: 1: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA; 2: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD; 3: Department of Psychiatry, Vanderbilt University, Nashville, TN; Issue Info: Oct1986, Vol. 44 Issue 4, p435; Subject Term: Anorexia nervosa; Subject Term: Body weight; Subject Term: Eating disorders; Subject Term: Food -- Caloric content; Subject Term: Body mass index; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Glueck, Charles J.
AU - Gordon, David J.
AU - Nelson, J. J.
AU - Davis, C. E.
AU - Tyroler, H. Alfred
T1 - Dietary and other correlates of changes in total and low density lipoprotein cholesterol in hypercholesterolemic men: the lipid research clinics coronary primary prevention trial.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/10//
VL - 44
IS - 4
M3 - Article
SP - 489
EP - 500
SN - 00029165
AB - Correlates of changes in total (TOTAL-C) and low density lipoprotein cholesterol (LDL-C) were examined in the 3806 hypercholesterolemic men of the Lipid Research Clinics Coronary Primary Prevention Trial. These correlates included changes in weight, dietary and alcohol intake, plasma glucose and thyroxine, cigarette smoking, packet count, lipid-lowering drugs other than cholestyramine, and antihypertensive drugs. In both placebo plus diet and cholestyramine plus diet treatment groups, decreases in Quetelet index and in saturated fat and cholesterol intake and increases in polyunsaturated fat intake were consistently associated with reductions in TOTAL-C and in LDL-C. In the cholestyramine group, plasma glucose and smoking were predictors of increased TOTAL-C and LDL-C; age and packet count were predictors of decreased TOTAL-C and LDL-C. Diuretic use was associated with increases in TOTAL-C in both groups and with increases in LDL-C in the cholestyramine group. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hypercholesteremia
KW - Low density lipoproteins
KW - Blood lipoproteins
KW - Hyperlipidemia
KW - Men
N1 - Accession Number: 91251615; Glueck, Charles J. 1; Gordon, David J. 2; Nelson, J. J. 3; Davis, C. E. 3; Tyroler, H. Alfred 3; Affiliations: 1: General Clinical Research Center, CLINFO Center, and Lipid Research Clinic, University of Cincinnati Medical Center, Cincinnati, OH; 2: Lipid Metabolism-Atherogenesis Branch, Division of Heart and Vascular Diseases, NHLBI, National Institutes of Health, Bethesda, MD; 3: Departments of Biostatistics and Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC; Issue Info: Oct1986, Vol. 44 Issue 4, p489; Subject Term: Hypercholesteremia; Subject Term: Low density lipoproteins; Subject Term: Blood lipoproteins; Subject Term: Hyperlipidemia; Subject Term: Men; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Spirtas, Robert
AU - Steinberg, Marshall
AU - Wands, Ralph C.
AU - Weisburger, Elizabeth K.
T1 - Identification and Classification of Carcinogens: Procedures of the Chemical Substances Threshold Limit Value Committee, ACGIH.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/10//
VL - 76
IS - 10
M3 - Article
SP - 1232
EP - 1235
PB - American Public Health Association
SN - 00900036
AB - Abstract: The Chemical Substances Threshold Limit Value Committee of the American Conference of Governmental Industrial Hygienists has refined its procedures for evaluating carcinogens. Types of epidemiologic and toxicologic evidence used are reviewed and a discussion is presented on how the Committee evaluates data on carcinogenicity. Although it has not been conclusively determined whether biological thresholds exist for all types of carcinogens, the Committee will continue to develop guidelines for permissible exposures to carcinogens. The Committee will continue to use the safety factor approach to setting Threshold Limit Values for carcinogens, despite its shortcomings. A compilation has been developed for lists of substances considered to be carcinogenic by several scientific groups. The Committee will use this information to help to identify and classify carcinogens for its evaluation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygienists
KW - CARCINOGENS -- Research
KW - CONFERENCES & conventions
KW - COMMITTEES
KW - ASSOCIATIONS, institutions, etc.
KW - CARCINOGENICITY testing
KW - THRESHOLD limit values (Industrial toxicology)
KW - INDUSTRIAL policy
KW - SAFETY factor in engineering
N1 - Accession Number: 4686805; Spirtas, Robert 1 Steinberg, Marshall 2 Wands, Ralph C. 3 Weisburger, Elizabeth K. 3; Affiliation: 1: National Cancer Institute, Landow Building, Room 4C-16, Bethesda, MD 20892 2: Hazelton Laboratories 3: Ralph C. Wands & Associates, Inc; Source Info: Oct86, Vol. 76 Issue 10, p1232; Subject Term: INDUSTRIAL hygienists; Subject Term: CARCINOGENS -- Research; Subject Term: CONFERENCES & conventions; Subject Term: COMMITTEES; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: CARCINOGENICITY testing; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: INDUSTRIAL policy; Subject Term: SAFETY factor in engineering; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boyd, Jeffrey H.
AU - Mościcki, Eve K.
T1 - Firearms and Youth Suicide.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/10//
VL - 76
IS - 10
M3 - Article
SP - 1240
EP - 1242
PB - American Public Health Association
SN - 00900036
AB - Abstract: The firearm suicide rate for persons aged 10 to 24 has increased from 2.3 per 100,000 in 1933 to 5.5 per 100,000 in 1982. Over the same period, the suicide rate for this age group by all methods other than firearms has only risen from 2.5 to 3.3. The most dramatic rise in the firearm suicide rate has occurred primarily since 1970, notably among males aged 15 to 24. During the 1960s and 1970s there was a substantial increase in the number of civilian firearms in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUICIDE
KW - FIREARMS
KW - AGE groups
KW - MALES
KW - FIREARMS owners
KW - FIREARMS ownership
KW - VIOLENT deaths
KW - AGE distribution (Demography)
KW - UNITED States
N1 - Accession Number: 4686817; Boyd, Jeffrey H. 1 Mościcki, Eve K. 1; Affiliation: 1: Epidemiology and Psychopathology Branch, Division of Clinical Research, National Institute of Mental Health; Source Info: Oct86, Vol. 76 Issue 10, p1240; Subject Term: SUICIDE; Subject Term: FIREARMS; Subject Term: AGE groups; Subject Term: MALES; Subject Term: FIREARMS owners; Subject Term: FIREARMS ownership; Subject Term: VIOLENT deaths; Subject Term: AGE distribution (Demography); Subject Term: UNITED States; NAICS/Industry Codes: 332992 Small Arms Ammunition Manufacturing; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 451119 All other sporting goods stores; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bader, Max
AU - Zhao-Yi Xu
AU - Blot, William J.
AU - Fraumeni Jr., Joseph F.
AU - Chamberlin, Ann N.
AU - Muller, Andreas
AU - Jessop, Dorothy Jones
AU - Newacheck, Paul W.
AU - Budetti, Peter P.
AU - Holfon, Neal
T1 - The Smoke-free Hospital, Allentown, PA.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/10//
VL - 76
IS - 10
M3 - Article
SP - 1248
EP - 1248
PB - American Public Health Association
SN - 00900036
AB - The article reports that HealthEast, the nonprofit parent company of the Allentown Hospital and Lehigh Valley Hospital Center in Pennsylvania, has enacted a no-smoking policy after conducting a smoking cessation program for staff, employees, volunteers and the public. The purpose of HealthEast is to encourage individuals to quit smoking for a smoke-free hospital environment as well as for personal health. The initiative represents the hospital management's commitment to public health. An anti-smoking campaign was introduced after a survey of the 3,500 employees at the two hospitals showed that the majority favored limiting smoking. Another survey will be conducted to measure the success of physicians participating in the no-smoking campaign.
KW - NONPROFIT organizations
KW - HOSPITAL management companies
KW - HOSPITALS
KW - SMOKING cessation
KW - NONSMOKING areas
KW - MEDICAL personnel
KW - PUBLIC health
KW - SMOKING
KW - HEALTH surveys
KW - PENNSYLVANIA
N1 - Accession Number: 4686833; Bader, Max Zhao-Yi Xu 1 Blot, William J. 2 Fraumeni Jr., Joseph F. 2 Chamberlin, Ann N. 3 Muller, Andreas 4 Jessop, Dorothy Jones 5 Newacheck, Paul W. 6 Budetti, Peter P. 6 Holfon, Neal 6; Affiliation: 1: Liaoning Province Public Health and Anti-Epidemic Station, Shenyang, People's Republic of China. 2: National Cancer Institute, Bethesda, MD 20892. 3: Program Manager, New Hampshire, Child Passenger Safety Program, Dartmouth Medical School, Department of Maternal and Child Health, Hanover, NH 03756. 4: Associate Professor, University of Oklahoma, Health Sciences Center, College of Public Health, Department of Health Administration, P. O. Box 26901, Oklahoma City, OK 73190. 5: Associate Professor of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. 6: Institute for Health Policy Studies, University of California, San Francisco 94143.; Source Info: Oct86, Vol. 76 Issue 10, p1248; Subject Term: NONPROFIT organizations; Subject Term: HOSPITAL management companies; Subject Term: HOSPITALS; Subject Term: SMOKING cessation; Subject Term: NONSMOKING areas; Subject Term: MEDICAL personnel; Subject Term: PUBLIC health; Subject Term: SMOKING; Subject Term: HEALTH surveys; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 813319 Other Social Advocacy Organizations; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621990 All other ambulatory health care services; Number of Pages: 2/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Zhao-Yi Xu
AU - Blot, William J.
AU - Fraumeni Jr., Joseph F.
T1 - Geographic Variation of Female Lung Cancer in China.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/10//
VL - 76
IS - 10
M3 - Letter
SP - 1249
EP - 1250
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Patterns of Site-Specific Displacement in Cancer Mortality Among Migrants: The Chinese in the United States," by H. King, J. Y. Li, F. B. Locke, E. S. Pollack and J. T. Tu in the previous issue.
KW - LETTERS to the editor
KW - LUNGS -- Cancer
KW - CHINESE -- United States
N1 - Accession Number: 21095904; Zhao-Yi Xu 1 Blot, William J. 2 Fraumeni Jr., Joseph F. 2; Affiliation: 1: Liaoning Province Public Health and Anti-Epidemic Station, Shenyang, People's Republic of China 2: National Cancer Institute, Bethesda, MD 2089; Source Info: Oct86, Vol. 76 Issue 10, p1249; Subject Term: LETTERS to the editor; Subject Term: LUNGS -- Cancer; Subject Term: CHINESE -- United States; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taube, Carl A.
AU - Schlenger, William E.
AU - Rupp, Agnes
AU - Whitmore, Roy W.
T1 - Validity of Medicaid Household Respondent Reporting of Ambulatory Visits for Mental Disorders.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 1986/10//
VL - 14
IS - 3
M3 - Article
SP - 243
EP - 256
PB - IOS Press
SN - 07479662
AB - Comparison with administrative records or "best estimate file" enables an evaluation of the accuracy of household reports of mental health use in the four-State Medicaid Household Survey conducted as part of the National Medical Care Utilization and Expenditure Survey. Underreporting of probability of ambulatory mental health use ranged from 14 to 24% compared to 5 to 7% for ambulatory health visits; household estimates of number of mental health visits seemed to be more accurate than administrative records. Household reporting of provider type seemed to be very accurate for psychiatrist visits, but there seemed to be a tendency to report psychologist visits as psychiatrist visits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAID
KW - MEDICAL care
KW - PSYCHOLOGISTS
KW - MENTAL health
KW - EVALUATION
KW - MENTAL illness
KW - PATHOLOGICAL psychology
KW - HOUSEHOLD surveys
KW - MEDICAL care surveys
KW - PSYCHIATRISTS
N1 - Accession Number: 6644336; Taube, Carl A. 1; Schlenger, William E. 2; Rupp, Agnes 2; Whitmore, Roy W. 2; Affiliations: 1: Acting Director, Division of Biometry and Applied Services, National Institute of Mental Health, U.S. Department of Health and Human Services, Rockville, Maryland 20857; 2: National Institute of Mental Health and Research Triangle Institute; Issue Info: Oct86, Vol. 14 Issue 3, p243; Thesaurus Term: MEDICAID; Thesaurus Term: MEDICAL care; Thesaurus Term: PSYCHOLOGISTS; Subject Term: MENTAL health; Subject Term: EVALUATION; Subject Term: MENTAL illness; Subject Term: PATHOLOGICAL psychology; Subject Term: HOUSEHOLD surveys; Subject Term: MEDICAL care surveys; Subject Term: PSYCHIATRISTS; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hawley-Nelson, Pamela
AU - Roop, Dennis R.
AU - Cheng, Christina K.
AU - Yuspa, Stuart H.
T1 - Regulated Synthesis of Low-Molecular-Weight Antigens in Keratinocyte Cell Cultures.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/10//
VL - 87
IS - 4
M3 - Article
SP - 454
EP - 459
SN - 0022202X
AB - Proteins from mouse epidermis cytosol extracts react on immunoblots with a polyclonal rabbit antiserum raised against rat skin calcium-binding protein (SCaBP), a parvalbumin of the panniculus carnosus. Three mouse epidermal proteins with molecular weights between 10-12K, which are distinct from SCaBP, are recognized by the antiserum. The synthesis of these proteins in keratinocyte culture is modulated by Ca++, as is the differentiation of the keratinocytes. Proliferating mouse keratinocytes in medium containing 0.07 mM Ca++ (low CaCa++) undergo terminal differentiation when the Ca++ concentration is elevated to 1.8 mM (high Ca++). Synthesis of the 3 antigens can be demonstrated when soluble extracts of keratinocytes labeled with [35S]methionine in low Ca++ medium are immunoprecipitated with anti-SCaBP serum. These antigens are not synthesized in cultures of dermal fibroblasts. When keratinocytes are switched to high Ca++ medium, synthesis of these antigens is greatly diminished over the course of 48-72 h. However, the antigens persist in differentiating cells. When proliferating keratinocytes in low Ca++ medium are exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), differentiation is induced in a subpopulation of cells, and specific antigen synthesis is transiently inhibited. The inhibition correlates with the time when many cells are differentiating in response to TPA. When proliferating keratinocytes are pulse-labeled with 32PO4, the 11 K antigen is phosphorylated and the phosphorylation is not enhanced by TPA exposure. All 3 antigens are synthesized in a reticulocyte lysate preparation with added newborn mouse epidermis messenger RNA or mRNA from keratinocytes cultured in low Ca++ medium. Thus, these antigens are likely to represent unique proteins rather than processed or degraded ones. The coordinately regulated expression of these antigens associated with the differentiation state of the keratinocyte proliferation and differentiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - LYMPHOMAS
KW - PROTEINS
KW - KERATINOCYTES
KW - EPIDERMIS
KW - CELLS
N1 - Accession Number: 12455495; Hawley-Nelson, Pamela 1,2 Roop, Dennis R. 1 Cheng, Christina K. 1 Yuspa, Stuart H. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 2: Department of Biology, Catholic University of America, Washington. D.C., U.S.A.; Source Info: Oct86, Vol. 87 Issue 4, p454; Subject Term: ANTIGENS; Subject Term: LYMPHOMAS; Subject Term: PROTEINS; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: CELLS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12455495
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Backlund Jr., Peter S.
AU - Carotti, Daniela
AU - Cantoni, Giulio L.
T1 - Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/10/15/
VL - 160
IS - 2
M3 - Article
SP - 245
EP - 251
PB - Wiley-Blackwell
SN - 00142956
AB - Examines the effects of 3-deazaaristeromycin and 3-deazaadenosine on RNA methylation and synthesis in the mouse macrophage cell line, RAW264. S-Adenosylhomocysteine accumulated in cells incubated with 3-deazaaristeromycin; Inhibition of messenger RNA synthesis by treatment of cells with 3-deazaadenosine and the inhibition of synthesis was not correlated with an inhibition of methylation.
KW - MESSENGER RNA
KW - METHYLATION
KW - MACROPHAGES
KW - CELL lines
KW - ADENOSINE
KW - MICE as laboratory animals
N1 - Accession Number: 12248600; Backlund Jr., Peter S. 1 Carotti, Daniela 1 Cantoni, Giulio L. 1; Affiliation: 1: Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda; Source Info: 10/15/86, Vol. 160 Issue 2, p245; Subject Term: MESSENGER RNA; Subject Term: METHYLATION; Subject Term: MACROPHAGES; Subject Term: CELL lines; Subject Term: ADENOSINE; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mendelson, Ella
AU - Landsma, David
AU - Druckmann, Shulamit
AU - Bustin, Michael
T1 - Immunofractionation of chromatin regions associated with histone H1º.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1986/10/15/
VL - 160
IS - 2
M3 - Article
SP - 253
EP - 260
PB - Wiley-Blackwell
SN - 00142956
AB - Reports on the binding of two monoclonal antibodies, which were elicited against histone H5, to purified rat liver chromatin. Immobilization of the monoclonal antibodies on CNBr-Sepharose; Use of the resulting immunoaffinity column to fractionate rat liver oligonucleosomes; Examination of DNA purified from the unfractionated nucleosomes, from the unbound nucleosomes and from the nucleosomes which were bound to the column.
KW - MONOCLONAL antibodies
KW - HISTONES
KW - LIVER
KW - CHROMATIN
KW - SEPHAROSE
KW - RATS as laboratory animals
N1 - Accession Number: 12248612; Mendelson, Ella 1 Landsma, David 1 Druckmann, Shulamit 1 Bustin, Michael 1; Affiliation: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Maryland; Source Info: 10/15/86, Vol. 160 Issue 2, p253; Subject Term: MONOCLONAL antibodies; Subject Term: HISTONES; Subject Term: LIVER; Subject Term: CHROMATIN; Subject Term: SEPHAROSE; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shiono, Patricia H.
AU - Klebanoff, Mark A.
T1 - Ethnic Differences in Preterm and Very Preterm Delivery.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/11//
VL - 76
IS - 11
M3 - Article
SP - 1317
EP - 1321
PB - American Public Health Association
SN - 00900036
AB - Abstract: Ethnic differences in preterm (<37 weeks) and very preterm (<33 weeks) delivery were evaluated in a prospective cohort of 28,330 women. Blacks had the highest rate of preterm and very preterm delivery, followed by Mexican-Americans, Asians, and Whites. Adjustment for maternal age, education, marital status, employment, parity, number of previous spontaneous or induced abortions, smoking and drinking during pregnancy, infant sex, and gestational age at initiation of prenatal care resulted in the following odds ratios for preterm delivery: 1.79 (1.55-2.08) for Blacks, 1.40 (1.19-1.63) for Mexican-Americans, 1.40 (1.16-1.69) for Asians, and 1.00 for Whites. The corresponding odds ratios for very preterm delivery were 2.35 (1.72-3.22) for Blacks, 1.31 (0.88-1.94) for Mexican-Americans, 1.10 (0.67-1.83) for Asians, and 1.00 for Whites. Exclusion of cases of premature rupture of membranes, placenta previa, and abruptio placenta did not explain the large ethnic differences. Although Whites and Mexican-Americans had similar birthweight distributions, Mexican-Americans had an increased risk for preterm delivery. Fifty-five per ¢ of low birthweight babies in Kaiser were preterm and this fraction did not vary substantially by ethnic group. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREMATURE labor
KW - PREMATURE infants
KW - ETHNICITY
KW - GRAVID uterus
KW - PLACENTA
KW - PAY equity
KW - INFLUENCE of age on ability
KW - PREGNANT women
KW - DURATION of pregnancy
N1 - Accession Number: 4686856; Shiono, Patricia H. 1 Klebanoff, Mark A. 1; Affiliation: 1: National Institute of Health, National Institute of Child Health and Human Development, Epidemiology Biometry Research Program, Landow Building, Room 7c16, Bethesda, MD 20892.; Source Info: Nov86, Vol. 76 Issue 11, p1317; Subject Term: PREMATURE labor; Subject Term: PREMATURE infants; Subject Term: ETHNICITY; Subject Term: GRAVID uterus; Subject Term: PLACENTA; Subject Term: PAY equity; Subject Term: INFLUENCE of age on ability; Subject Term: PREGNANT women; Subject Term: DURATION of pregnancy; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moment, Gairdner B.
T1 - BIOLOGY OF GERONTOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1986/11//
VL - 36
IS - 10
M3 - Book Review
SP - 693
EP - 693
SN - 00063568
AB - Reviews the book "The Molecular Biology of Aging," edited by A.D. Woodhead, A.D. Blackett, and A. Hollaender.
KW - Molecular biology
KW - Nonfiction
KW - Molecular Biology of Aging (Book)
N1 - Accession Number: 10114210; Moment, Gairdner B. 1,2; Affiliations: 1: Guest Scientist, National Institute on Aging; 2: Professor Emeritus of Biology, Goucher College, Baltimore, MD 21204; Issue Info: Nov86, Vol. 36 Issue 10, p693; Thesaurus Term: Molecular biology; Subject Term: Nonfiction; Reviews & Products: Molecular Biology of Aging (Book); Number of Pages: 8/9p; Document Type: Book Review; Full Text Word Count: 832
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Elgjo, Kjell
AU - Reichelt, Karl L.
AU - Hennings, Henry
AU - Michael, Delores
AU - Yuspa, Stuart H.
T1 - Purified Epidermal Pentapeptide Inhibits Proliferation and Enhances Terminal Differentiation in Cultured Mouse Epidermal Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/11//
VL - 87
IS - 5
M3 - Article
SP - 555
EP - 558
SN - 0022202X
AB - Skin extracts contain an epidermal mitosis inhibitor that recently has been purified and identified as a pentapeptide. To develop an in vitro assay system for further biologic characterization, primary mouse epidermal cells and an established mouse epidermal cell line (line 308) were used for testing of the purified pentapeptide. In primary cell cultures the mitotic activity, as estimated by means of vinblastine, was reversibly inhibited by 44% at a peptide concentration of 10-8 M in high-calcium (1.2 mM Ca++), and by 27-38% at peptide concentrations of 10-10 and 10-8 M in low-calcium (0.02 mM Ca++) medium. The 308 cells were inhibited by 46% at a peptide concentration of 10-6 M but only after the cells had reached near-confluence and had a moderate rate of proliferation. A low concentration of adrenalin (0.18 μg/ml) in the medium rendered the primary cultures more sensitive to the peptide. After repeated peptide treatments over 24 h, the number of cornified envelopes (a marker of terminal differentiation) was increased both in primary cultures and in the 308 cells. The epidermal pentapeptide thus seems to influence both proliferation and terminal differentiation in cultured mouse epidermal cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMIS
KW - CELLS
KW - PEPTIDES
KW - CELL proliferation
KW - CELL culture
KW - CELL differentiation
N1 - Accession Number: 12455733; Elgjo, Kjell 1 Reichelt, Karl L. 2 Hennings, Henry 3 Michael, Delores 3 Yuspa, Stuart H. 3; Affiliation: 1: Institute of Pathology, Rikshospitalet, Oslo, Norway. 2: Pediatric Research Institute, Rikshospitalet, Oslo, Norway. 3: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Nov86, Vol. 87 Issue 5, p555; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: PEPTIDES; Subject Term: CELL proliferation; Subject Term: CELL culture; Subject Term: CELL differentiation; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12455733
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krichevsky, Micah I.
AU - Krasse, Bo
T1 - Considerations and conclusions.
JO - Oral Microbiology & Immunology
JF - Oral Microbiology & Immunology
Y1 - 1986/11//
VL - 1
IS - 1
M3 - Article
SP - 87
EP - 91
SN - 09020055
AB - Diagnostic microbiological methods play an ever greater role in epidemiological studies and clinical trials related to dental caries and periodontal diseases. Further, such methods can serve the clinician as valuable adjuncts to case history and clinical examination for diagnosis, treatment, and prevention of disease. A variety of diagnostic methods are becoming available and show promise in the hands of individual investigators and clinicians. The further development of diagnostic microbiological methods will require collaborative studies with careful consideration of basic ecological and epidemiological principles as well as modern technology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Oral Microbiology & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Technology
KW - Dental caries
KW - Periodontal disease
KW - Periodontal disease -- Prevention
KW - Dental pathology
N1 - Accession Number: 12547361; Krichevsky, Micah I. 1; Krasse, Bo 2; Affiliations: 1: Microbial Systematics Section 1, Epidemiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.; 2: Disease Prevention Branch, Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.; Issue Info: Nov1986, Vol. 1 Issue 1, p87; Thesaurus Term: Epidemiology; Thesaurus Term: Technology; Subject Term: Dental caries; Subject Term: Periodontal disease; Subject Term: Periodontal disease -- Prevention; Subject Term: Dental pathology; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1399-302X.ep12547361
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - QUINN, THOMAS C.
AU - MANN, JONATHAN M.
AU - CURRAN, JAMES W.
AU - PIOT, PETER
T1 - AIDS in Africa: An Epidemiologic Paradigm.
JO - Science
JF - Science
Y1 - 1986/11/21/
VL - 234
IS - 4779
M3 - Article
SP - 955
EP - 963
SN - 00368075
AB - Cases of the acquired immune deficiency syndrome (AIDS) have been reported in countries throughout the world. Initial surveillance studies in Central Africa suggest an annual incidence of AIDS of 550 to 1000 cases per million adults. The male to female ratio of cases is 1:1, with age- and sex-specific rates greater in females less than 30 years of age and greater in males over age 40. Clinically, AIDS in Africans is often characterized by a diarrhea-wasting syndrome, opportunistic infections, such as tuberculosis, cryptococcosis, and cryptosporidiosis, or disseminated Kaposi's sarcoma. From 1 to 18% of healthy blood donors and pregnant women and as many as 27 to 88% of female prostitutes have antibodies to human immunodeficiency virus (HIV). The present annual incidence of infection is approximately 0.75% among the general population of Central and East Africa. The disease is transmitted predominately by heterosexual activity, parenteral exposure to blood transfusions and unsterilized needles, and perinatally from infected mothers to their newborns, and will continue to spread rapidly where economic and cultural factors favor these modes of transmission. Prevention and control of HIV infection through educational programs and blood bank screening should be an immediate public health priority for all African countries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692402; QUINN, THOMAS C. 1,2 MANN, JONATHAN M. 3 CURRAN, JAMES W. 4 PIOT, PETER 5; Affiliation: 1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2: Johns Hopkins University School of Medicine, Baltimore, MD 21205 3: Control Prograr on AIDS, World Health OrgLanution, 1211 Geneva 27, Switzerland 4: AIDS Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30333 5: Department of Microbiology, Institute of Tropical Medicine, B-2000 Antwerp, Belgium; Source Info: 11/21/1986, Vol. 234 Issue 4779, p955; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KOZEL, NICHOLAS J.
AU - ADAMS, EDGAR H.
T1 - Epidemiology of Drug Abuse: An Overview.
JO - Science
JF - Science
Y1 - 1986/11/21/
VL - 234
IS - 4779
M3 - Article
SP - 970
EP - 974
SN - 00368075
AB - Issues regarding the use of epidemiology in drug abuse research are discussed and systems for monitoring national trends and identifying risk factors are described. Data indicate a general decline in marijuana use among youth, a cohort aging effect among heroin and marijuana users, and increased prevalence and health consequences associated with cocaine use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692404; KOZEL, NICHOLAS J. 1 ADAMS, EDGAR H. 1; Affiliation: 1: Division of Epidemiology and Statistical Analysis, National Institute on Drug Abuse, Rockville, MD 20857; Source Info: 11/21/1986, Vol. 234 Issue 4779, p970; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WRIGHT, CONNIE M.
AU - FELBER, BARBARA K.
AU - PASKALIS, HARRY
AU - PAVLAKIS, GEORGE N.
T1 - Expression and Characterization of the Trans- Activator of HTLV-III/LAV Virus.
JO - Science
JF - Science
Y1 - 1986/11/21/
VL - 234
IS - 4779
M3 - Article
SP - 988
EP - 992
SN - 00368075
AB - The human T-lymphotropic retrovirus HTLV-III/LAV encodes a trans-activator that increases viral gene expression. We expressed this trans-activator in animal cells and studied its structural and functional characteristics. The putative trans-activator protein was immunoprecipitated from overproducing stable cell lines and shown to migrate as a 14-kilodalton polypeptide on sodium dodecyl sulfate-polyacrylamide gels. S1 nuclease mapping experiments showed that the trans-activator increases the levels of steady-state messenger RNA transcribed from the viral long terminal repeat promoter. Sequences within the R region of the HTLV-III/LAV long terminal repeat are essential for trans-activation. Quantitations of messenger RNA and protein showed that the protein increase was greater than the messenger RNA increase in CV1 and HeLa cells, indicating that more than one mechanism was responsible for the. trans--activation and that cell type-specific factors may determine the final level of trans-activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692409; WRIGHT, CONNIE M. 1,2 FELBER, BARBARA K. 1 PASKALIS, HARRY 1 PAVLAKIS, GEORGE N. 1; Affiliation: 1: Bionetics Research, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD 21701 2: Department of Biology, University of Maryland, Baltimore County, Catonsville, MD 21228; Source Info: 11/21/1986, Vol. 234 Issue 4779, p988; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - FURANo, ANTHONY V.
AU - OWENS, GR$LGORY P.
AU - CHAUDHARI, NIRUPA
AU - HAHN, WILLILA?M E.
T1 - Brain "Identifier Sequence".
JO - Science
JF - Science
Y1 - 1986/11/21/
VL - 234
IS - 4779
M3 - Article
SP - 1005
EP - 1006
SN - 00368075
N1 - Accession Number: 84692414; FURANo, ANTHONY V. 1 OWENS, GR$LGORY P. 2 CHAUDHARI, NIRUPA 2 HAHN, WILLILA?M E. 2; Affiliation: 1: National Institute of Diabetes and D,qestive and Kidney Diseases, National Institutes of Health, Building 8, Room 203, Bethesda, MD 20892 2: Department of Celular and Structural Biology, University of Colorado School of Medicine, Denver, CO 80262; Source Info: 11/21/1986, Vol. 234 Issue 4779, p1005; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BLACK, SIMON
T1 - Reversible Interconversion of Two Forms of a Valyl-tRNA Synthetase-Containing Protein Complex.
JO - Science
JF - Science
Y1 - 1986/11/28/
VL - 234
IS - 4780
M3 - Article
SP - 1111
EP - 1114
SN - 00368075
AB - When an enzyme-containing complex from yeast was incubated in a buffered solutiop at room temperature, the valyl-transfer JLNA synthetase activity and total protein oscillated synchronously between two physical states. This observation suggests a regulatory process that. controls a number of enzymes as a group, an integrated function of a kind not heretofore recognized. The two forms of the complex were separated by anmnonium sulfate precipitation of one of them in samples withdrawn from the incubated solution every 30 seconds. Glutathione and dithiothreitol in high concentrations (50 mM) enhance formation of the 50% saturated ammonium sulfatesoluble form. Oxidized glutathione, diphosphopyridine nudeotide, triphosphopyriI dine nucleotide, and a mercurial thiol binding agent in moderate concentrations (0.1 to 1.0 mM) shift the distribution toward the precipitable forn. It is suggested that the two forms represent functional and nonfimctional complex-bound enzymes which are interconverted in response to oxidoreductive signals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692452; BLACK, SIMON 1; Affiliation: 1: Section on Pharmacology, Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892; Source Info: 11/28/1986, Vol. 234 Issue 4780, p1111; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HUANG, MING-TA
AU - VEVCH, RICHARD L.
AU - NELSON, THOMAS
AU - DIENEL, GERALD
AU - SOKOLOFF, LOUIS
T1 - Glucose-6-Phosphatase Activity in Brain.
JO - Science
JF - Science
Y1 - 1986/11/28/
VL - 234
IS - 4780
M3 - Article
SP - 1128
EP - 1129
SN - 00368075
N1 - Accession Number: 84692457; HUANG, MING-TA 1 VEVCH, RICHARD L. 1 NELSON, THOMAS 2 DIENEL, GERALD 2 SOKOLOFF, LOUIS 2; Affiliation: 1: Laboratory of Metabolism, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, 20852 2: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, 20892; Source Info: 11/28/1986, Vol. 234 Issue 4780, p1128; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Albanes, Demetrius
AU - Jones, D. Yvonne
AU - Chumlea, W. Cameron
T1 - Correlations of body mass indices with weight, stature, and body composition in men and women in NHANES I and II.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/12//
VL - 44
IS - 6
M3 - Article
SP - 725
EP - 731
SN - 00029165
AB - It is useful to develop indices of weight and stature, or body mass indices (BMIs), that are highly correlated with weight, are independent of stature,and accurately reflect body composition. The anthropometric data collected in the NHANES I (1971-74) and NHANES II (1976-80) US population samples were used to test the statistical characteristics and biologic correlations of various BMIs reported in the literature. BMIs that are independent of stature and still highly correlated to weight (r = 0.89-0.98) over all ages and distributions of fatness and leanness are W/S² in men and both W/S and W/S1.5 in women. These BMIs are also highly correlated to measured and calculated estimates of body composition including subscapular skinfold thickness (r = 0.78-0.80), arm circumference (r = 0.83-0.89), and arm fat area (r = 0.71-0.83). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Body weight
KW - Body mass index
KW - Human body composition
KW - Men
KW - Women
KW - body composition
KW - body mass index
KW - body size
KW - obesity
KW - stature
KW - Weight
N1 - Accession Number: 90726550; Micozzi, Marc S. 1; Albanes, Demetrius 1; Jones, D. Yvonne 1; Chumlea, W. Cameron 2; Affiliations: 1: National Cancer Institute, NIH, Bethesda, MD; 2: Department of Pediatrics, Wright State University School of Medicine, Dayton, OH; Issue Info: Dec1986, Vol. 44 Issue 6, p725; Subject Term: Body weight; Subject Term: Body mass index; Subject Term: Human body composition; Subject Term: Men; Subject Term: Women; Author-Supplied Keyword: body composition; Author-Supplied Keyword: body mass index; Author-Supplied Keyword: body size; Author-Supplied Keyword: obesity; Author-Supplied Keyword: stature; Author-Supplied Keyword: Weight; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reddy, Vinodini
AU - Bhaskaram, P.
AU - Raghuramulu, N.
AU - Milton, Roy C.
AU - Rao, Vithal
AU - Madhusudan, J.
AU - Radha Krishna, K. V.
T1 - Relationship between measles, malnutrition, and blindness: a prospective study in Indian children.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/12//
VL - 44
IS - 6
M3 - Article
SP - 924
EP - 930
SN - 00029165
AB - A prospective study was conducted in slum children to determine the incidence of post-measles corneal disease and to clarify its relationship with nutritional status. A total of 318 cases of measles were identified over a period of 15 mo; maximum incidence was observed for children between 1-2 yr. Most of the children showed weight loss and serum proteins decrease during the acute stage of measles. Corneal lesions were observed in 3% of the children, and the lesions responded well to treatment. Serum vitamin A and RBP levels were significantly depressed during the acute stage of measles but were restored to normal 8 wk after recovery. There were no significant differences in the serum levels for those with and without eye lesions, which suggests that these lesions may not be mediated simply through the effect of infection on serum concentration of vitamin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Measles
KW - Malnutrition
KW - Nutrition disorders
KW - Blindness
KW - blindness
KW - malnutrition
N1 - Accession Number: 90726573; Reddy, Vinodini 1; Bhaskaram, P. 1; Raghuramulu, N. 1; Milton, Roy C. 2; Rao, Vithal 1; Madhusudan, J. 1; Radha Krishna, K. V. 1; Affiliations: 1: National Institute of Nutrition, Hyderabad, India; 2: National Eye Institute, Bethesda, MD; Issue Info: Dec1986, Vol. 44 Issue 6, p924; Thesaurus Term: Virus diseases; Subject Term: Measles; Subject Term: Malnutrition; Subject Term: Nutrition disorders; Subject Term: Blindness; Author-Supplied Keyword: blindness; Author-Supplied Keyword: malnutrition; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Maynard, Charles
AU - Fisher, Lloyd D.
AU - Passamani, Eugene R.
AU - Pullum, Thomas
T1 - Blacks in the Coronary Artery Surgery Study (CASS): Race and Clinical Decision Making .
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/12//
VL - 76
IS - 12
M3 - Article
SP - 1446
EP - 1448
PB - American Public Health Association
SN - 00900036
AB - Abstract: For patients enrolled in the Coronary Artery Surgery Study (CASS), surgery was recommended for 46.5 per ¢ of Blacks and 59.4 per ¢ of Whites, despite similar clinical and angiographic characteristics. Of those recommended, 80.5 per ¢ of Blacks and 90.4 per ¢ of Whites had bypass surgery. These differences were most apparent for Black laborers. Overall, only 38.0 per ¢ of Blacks had coronary artery bypass surgery, whereas 58.4 per ¢ of Whites received surgery. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY artery bypass
KW - CORONARY arteries -- Surgery
KW - HEALTH behavior
KW - HEALTH & race
KW - HUMAN behavior
KW - MEDICAL anthropology
KW - AFRICAN Americans
KW - DECISION making
KW - UNITED States
N1 - Accession Number: 4693464; Maynard, Charles 1 Fisher, Lloyd D. 1 Passamani, Eugene R. 1 Pullum, Thomas 2; Affiliation: 1: Departments of Biostatistics and Sociology, University of Washington, Seattle 2: National Heart, Lung, and Blood Institute, Bethesda, MD; Source Info: Dec1986, Vol. 76 Issue 12, p1446; Subject Term: CORONARY artery bypass; Subject Term: CORONARY arteries -- Surgery; Subject Term: HEALTH behavior; Subject Term: HEALTH & race; Subject Term: HUMAN behavior; Subject Term: MEDICAL anthropology; Subject Term: AFRICAN Americans; Subject Term: DECISION making; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Mackintosh, Douglas
AU - Mundey, Lynette
AU - Fischer, Glen
AU - Morgan, Edward
T1 - Condom Usage by IV Drug Users.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/12//
VL - 76
IS - 12
M3 - Letter
SP - 1460
EP - 1460
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article in the previous issue that involves the contraceptive practices among female drug users.
KW - LETTERS to the editor
KW - CONTRACEPTIVES
N1 - Accession Number: 21085071; Mackintosh, Douglas 1 Mundey, Lynette 1 Fischer, Glen 2 Morgan, Edward 3; Affiliation: 1: Vice President, Chief Medical Officer National Capitol Systems, Inc., Falls Church, VA 22041 2: AIDS/Drug Abuse Consultant, Richmond, VA 3: Training and Education Advisor, National Institute on Drug Abuse, Rockville, MD; Source Info: Dec1986, Vol. 76 Issue 12, p1460; Subject Term: LETTERS to the editor; Subject Term: CONTRACEPTIVES; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; Number of Pages: 4/9p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoel, D. G.
AU - Yanagawa, T.
T1 - Incorporating Historical Controls in Testing for a Trend in Proportions.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1986/12//
VL - 81
IS - 396
M3 - Article
SP - 1095
SN - 01621459
AB - The testing of chemicals for carcinogenic activity in lifetime rodent bioassays has produced a large amount of data on a few strains of mice and rats. Because of the use of fixed protocols in repeated experiments, the opportunity presents itself for using this historical data in the analysis of a current experiment. What has been considered is the statistical incorporation of the historical control data into the current control group to increase the power of the test. This is especially relevant when dealing with tumors of a rare type where the toxicologist will place great significance on their occurrence in a treatment group. Experimentally it is assumed that three groups of about 50 animals each are tested at two treatment levels and a control The response for each treatment group is assumed to be binomial. Further it is assumed that the probability of an animal with a tumor in the control group has a beta distribution that is determined from the historical control data. Several authors (Dempster, Selwyn, and Weeks 1983; Hoel 1983; Tarone 1982) have investigated the problem of testing for linear trend in proportions when historical information is available. In this article we give a locally most powerful test of trend for binomial response data by using a beta prior distribution for the historical control information. This generalized test is closely related to Tarone's statistic and generalizes the conditional test of Hoel. Under various conditions on the beta parameters (alpha, beta), the asymptotic distribution of the test statistic is given under the null hypothesis Ho of no trend in proportions and for a general sequence of alternative hypotheses that converge to Ho. Using these results, the asymptotic gain due to the incorporation of historical controls is given For the usual bioassay design the... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL hypothesis testing
KW - LINEAR models (Statistics)
KW - PROBABILITY theory
KW - BIOLOGICAL assay
KW - CARCINOGENICITY testing
KW - RODENTS
KW - ASYMPTOTIC theory
KW - CARCINOGENESIS
KW - TOXICOLOGISTS
KW - TUMORS
KW - Beta-binomial distribution.
KW - Carcinogenesis
KW - Dichotomous data
KW - Linear trend
N1 - Accession Number: 4612673; Hoel, D. G. 1; Yanagawa, T. 2,3; Affiliations: 1: Program Director, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; 2: Visiting Scientist, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; 3: Assistant Professor, Department of Mathematics, Kyushu University 33, Fukuoka 812, Japan.; Issue Info: Dec86, Vol. 81 Issue 396, p1095; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: PROBABILITY theory; Subject Term: BIOLOGICAL assay; Subject Term: CARCINOGENICITY testing; Subject Term: RODENTS; Subject Term: ASYMPTOTIC theory; Subject Term: CARCINOGENESIS; Subject Term: TOXICOLOGISTS; Subject Term: TUMORS; Author-Supplied Keyword: Beta-binomial distribution.; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Dichotomous data; Author-Supplied Keyword: Linear trend; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2006-06431-030
AN - 2006-06431-030
AU - Wolfe, Barry E.
T1 - Sing the Body Eclectic.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1986/12//
VL - 31
IS - 12
SP - 975
EP - 976
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06431-030. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Wolfe, Barry E.; Affective and Anxiety Disorders Research Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061127. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Eclectic Psychotherapy; Gestalt Therapy; Psychotherapy. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Smith, Edward W. L. The Body in Psychotherapy=Jefferson, NC: McFarland, 1985. 198 pp. $18.95; 1985. Page Count: 2. Issue Publication Date: Dec, 1986.
AB - Reviews the book, The Body in Psychotherapy by Edward W. L. Smith (see record [rid]2001-16811-000[/rid]). In Smith's new book the ecstatic has been exchanged for the eclectic. The result is an intriguing, surprisingly well-specified, integrated approach to psychotherapy. Smith integrates a number of body therapies, including bioenergetics, psychomotor therapy, Brown's organismic psychotherapy, Kelley's Radix, and Reich's orgonomy. These body therapies are, in turn, integrated with the theory and techniques of Gestalt therapy. Smith's concept of normal functioning is based on need satisfaction. What Smith sets out to do he does well. The difficulties with this book concern mainly what Smith did not undertake. A second difficulty involves Smith's system of categorization. A final problem inheres in all bodily oriented approaches to psychotherapy--the relative deemphasis of interpersonal issues in the generation and maintenance of psychopathology. By and large, however, this is a lucid presentation of a typically lubricious topic. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - body therapies
KW - body eclectic
KW - psychotherapy
KW - bioenergetics
KW - psychomotor therapy
KW - organismic psychotherapy
KW - Radix
KW - orgonomy
KW - Gestalt therapy
KW - 1986
KW - Eclectic Psychotherapy
KW - Gestalt Therapy
KW - Psychotherapy
KW - 1986
U2 - Smith, Edward W. L. (1985); The Body in Psychotherapy; Jefferson, NC: McFarland, 1985. 198 pp. $18.95
DO - 10.1037/024337
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06431-030&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SUZDAK, PETER D.
AU - GLOWA, JOHN R.
AU - CRAWLEY, JACQUELINE N.
AU - SCHWARTZ, ROCHELLE D.
AU - SKOLNICK, PHIL
AU - PAUL, STEVEN M.
T1 - A Selective Imidazobenzodiazepine Antagonist of Ethanol in the Rat.
JO - Science
JF - Science
Y1 - 1986/12/05/
VL - 234
IS - 4781
M3 - Article
SP - 1243
EP - 1247
SN - 00368075
AB - Ethanol, at pharmacologically relevant concentrations of 20 to 100 mM, stimulates 'yaminobutyric (GABA) receptor-mediated uptake of 36Cl-labeled chlorine into isolated brain vesicles. One drug that acts at GABA-benzodiazepine receptors, the imidazobenzodiazepine Ro15-4513, has been found to be a potent antagonist of ethanolstimulated 36C1- uptake into brain vesicles, but it fails to antagonize either pentobarbital- or muscimol-stimulated 36Cl- uptake. Pretreatment of rats with Ro15-4513 blocks the anticonflict activity oflow doses ofethanol (but not pentobarbital) as well as the behavioral intoxication observed with higher doses of ethanol. The effects of Rol5- 4513 in antagonizing ethanol-stimulated 36C1- uptake and behavior are completely blocked by benzodiazepine receptor antagonists. However, other benzodiazepine receptor inverse agonists fail to antagonize the actions of ethanol in vitro or in vivo, suggesting a novel interaction of Rol5-4513 with the GABA receptor-coupled chloride ion channel complex. The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions of ethanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460414; SUZDAK, PETER D. 1 GLOWA, JOHN R. 1 CRAWLEY, JACQUELINE N. 1 SCHWARTZ, ROCHELLE D. 1 SKOLNICK, PHIL 2 PAUL, STEVEN M. 1; Affiliation: 1: Section on Molecular Pharmacology and Preclinical Studies, Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2: Section on Neurobiology, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Heath, Bethesda, MD 20892; Source Info: 12/5/1986, Vol. 234 Issue 4781, p1243; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ziegler, Regina G.
AU - Wilcox III, Homer B.
AU - Mason, Thomas J.
AU - Bill, Joanne S.
AU - Virgo, Phillip W.
T1 - Seasonal variation in intake of carotenoids and vegetables and fruits among white men in New Jersey.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 107
EP - 114
SN - 00029165
AB - In a population-based case-control study of lung cancer among New Jersey men, usual adult consumption of many vegetables and fruits was included in the interview to assess the protective potential of carotenoids. With data from 900 controls the percentage of New Jersey white men who eat specific vegetables and fruits primarily in certain seasons, the relative importance of in-season and out-of-season consumption, and the median length of season were determined. Although first asking whether a food item was consumed all-year-round or primarily in certain seasons and then asking for the appropriate frequency of consumption facilitated the interview, obtaining out-of-season frequency of consumption and length of season was not necessary. Substituting 0 for reported out-of-season frequencies and 3 mo for reported season lengths reduced slightly the observed associations between diet and lung cancer risk but did not modify the overall pattern noted. Carotenoid intake in winter-fall was estimated to be about two-thirds that in summer-spring. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vegetables
KW - Fruit
KW - Carotenoids
KW - Biological pigments
KW - New Jersey
KW - Cancer
KW - carotenoids
KW - fruit
KW - lung
KW - seasonal
KW - vegetables
N1 - Accession Number: 91095754; Ziegler, Regina G. 1,2,3; Wilcox III, Homer B. 1,2,3; Mason, Thomas J. 1,2,3; Bill, Joanne S. 1,2,3; Virgo, Phillip W. 1,2,3; Affiliations: 1: Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD; 2: Cancer Epidemiology Services, New Jersey State Department of Health, Trenton, NJ; 3: ORI, Inc, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p107; Thesaurus Term: Vegetables; Thesaurus Term: Fruit; Subject Term: Carotenoids; Subject Term: Biological pigments; Subject: New Jersey; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: carotenoids; Author-Supplied Keyword: fruit; Author-Supplied Keyword: lung; Author-Supplied Keyword: seasonal; Author-Supplied Keyword: vegetables; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Donato, Karen A.
T1 - Efficiency and utilization of various energy sources for growth.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 164
EP - 167
SN - 00029165
AB - The article focuses on a study which investigates the efficiency of use of energy sources in animals and human subjects based on comparing the metabolic effects, such as growth, fat deposition, and protein deposition. Topics include explanations for energy concepts, increased efficiency of energy utilization from fat during growth.
KW - Energy consumption
KW - Fats & oils
KW - Food -- Fat content
KW - Food -- Protein content
KW - Diet
N1 - Accession Number: 91095765; Donato, Karen A. 1; Affiliations: 1: Nutrition Coordinating Committee, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p164; Thesaurus Term: Energy consumption; Subject Term: Fats & oils; Subject Term: Food -- Fat content; Subject Term: Food -- Protein content; Subject Term: Diet; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Poirier, Lionel A.
T1 - Stages in carcinogenesis: alteration by diet.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 185
EP - 191
SN - 00029165
AB - The article focuses on the stages of chemical carcinogenesis which includes carcinogen metabolism, initiation and promotion and tumor cell progression, and tumor growth and development. The first set of stages is based upon he electrophilic hypothesis of carcinogenesis, second stage offers distinction between initiation and promotion and the promotion stage shows formation of follicular carcinomas in the thyroid gland of methylnitrosourea-iitiated rats fed an iodine-deficient diet.
KW - Carcinogenesis
KW - Malnutrition
KW - Thyroid gland
KW - Food habits
KW - Metabolism
N1 - Accession Number: 91095768; Poirier, Lionel A. 1; Affiliations: 1: Nutrition and Metabolism Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p185; Thesaurus Term: Carcinogenesis; Subject Term: Malnutrition; Subject Term: Thyroid gland; Subject Term: Food habits; Subject Term: Metabolism; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simopoulos, Artemis P.
T1 - Obesity and carcinogenesis: historical perspective.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 271
EP - 276
SN - 00029165
AB - The article offers information on a study which shows the association of obesity with reduced life expectancy. Topics include major causes of excess cancer mortality among women, association between overweight and cancer of the breast and endometrium and relationship of obesity to cardiovascular disease.
KW - Carcinogenesis
KW - Obesity
KW - Life expectancy
KW - Weight loss
KW - Nutrition disorders
N1 - Accession Number: 91095782; Simopoulos, Artemis P. 1; Affiliations: 1: Nutrition Coordinating Committee, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p271; Thesaurus Term: Carcinogenesis; Subject Term: Obesity; Subject Term: Life expectancy; Subject Term: Weight loss; Subject Term: Nutrition disorders; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Greenwald, Peter
AU - Clifford, Carolyn
AU - Butrum, Ritva R.
AU - Iverson, Donald C.
T1 - Feasibility studies of a low-fat diet to prevent or retard breast cancer.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 347
EP - 353
SN - 00029165
AB - The article focuses on a study that determine whether low-fat diets can reduce the incidence of breast cancer in high-risk women or reduce the likelihood of recurrence of breast cancer in women. Topics include importance of randomized controlled intervention trials, dietary fat as a risk factor for breast cancer and low-fat trial in relation with other adjuvant medical therapy.
KW - Carcinogens
KW - Fat
KW - Lipids
KW - Breast cancer
KW - Tumors
N1 - Accession Number: 91095795; Greenwald, Peter 1; Clifford, Carolyn 1; Butrum, Ritva R. 1; Iverson, Donald C. 1; Affiliations: 1: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Jan1987, Vol. 45 Issue 1, p347; Thesaurus Term: Carcinogens; Subject Term: Fat; Subject Term: Lipids; Subject Term: Breast cancer; Subject Term: Tumors; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kessler, Larry G.
AU - Burns, Barbara J.
AU - Shapiro, Sam
AU - Tischler, Gary L.
AU - George, Linda K.
AU - Hough, Richard L.
AU - Bodison, Dorothea
AU - Miller, Richard H.
T1 - Psychiatric Diagnoses of Medical Service Users: Evidence from the Epidemiologic Catchment Area Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/01//
VL - 77
IS - 1
M3 - Article
SP - 18
EP - 24
PB - American Public Health Association
SN - 00900036
AB - Abstract: Based on data from the live sites of the National Institute of Mental Health-sponsored Epidemiologic Catchment Area (ECA) Program this paper examines the prevalence of psychiatric disorder among recent medical service users versus nonusers, with a particular focus on affective disorders, substance abuse/dependence, and phobias. The rate of current Diagnostic Interview Schedule (DIS) disorders among medical users in all five ECA sites is 21.7 per ¢ (slightly higher than general population rates) versus 16.7 per ¢ among nonusers: there is generally no difference between users and nonusers with past DIS diagnoses. Affective disorders were among the most common mental disorders of medical service users, especially among females, with little variation between sites: females: users: 6.9 per ¢ to 9.3 per ¢, nonusers: 3.4 per ¢ to 6.4 per ¢ and males: users: 3.3 per ¢ to 6.5 per ¢. nonusers: 1.2 per ¢ to 4.1 per ¢. Rates of phobia,, among persons using medical services are also higher than among nonusers. Substance abuse disorders are at least as common among persons who use medical services 18 per ¢ to 14 per ¢ o[ male users) as among those who do not 19 per ¢ to 11 per ¢ of male nonusers). The high rates of affective disorders among women and of substance abuse among male medical service risers underscore the need to increase the ability of general medical practitioners to recognize and manage or refer these conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOLOGICAL psychology
KW - MENTAL illness
KW - MENTAL depression
KW - AFFECTIVE disorders
KW - MENTAL disabilities
KW - HEALTH care reform
KW - HOME care services
KW - ANXIETY sensitivity
KW - NATIONAL Institute of Mental Health (U.S.)
N1 - Accession Number: 4949038; Kessler, Larry G. 1,2,3,4 Burns, Barbara J. 5 Shapiro, Sam 1,2,3,4 Tischler, Gary L. George, Linda K. Hough, Richard L. Bodison, Dorothea 1,2,3,4 Miller, Richard H.; Affiliation: 1: Shapiro, Johns Hopkins University 2: Tischler, Yale University 3: George, Duke University 4: Miller, Washington University 5: Deputy Director, Division of Biometry and Applied Sciences, National Institute of Mental Health, 5600 Fishers Lane, Room 18C26, Rockville, MD 20587; Source Info: Jan1987, Vol. 77 Issue 1, p18; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL illness; Subject Term: MENTAL depression; Subject Term: AFFECTIVE disorders; Subject Term: MENTAL disabilities; Subject Term: HEALTH care reform; Subject Term: HOME care services; Subject Term: ANXIETY sensitivity; Company/Entity: NATIONAL Institute of Mental Health (U.S.); NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagel, James E.
T1 - MOLECULAR IMMUNOLOGY.
JO - BioScience
JF - BioScience
Y1 - 1987/01//
VL - 37
IS - 1
M3 - Book Review
SP - 75
EP - 76
SN - 00063568
AB - Reviews the book 'Molecular Immunology,' edited by M. Zouhair Atassi, Carel J. van Oss and Darryl R. Absolom.
KW - Immunology
KW - Nonfiction
KW - Molecular Immunology (Book)
N1 - Accession Number: 10095913; Nagel, James E. 1; Affiliations: 1: National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, MD 21224; Issue Info: Jan1987, Vol. 37 Issue 1, p75; Thesaurus Term: Immunology; Subject Term: Nonfiction; Reviews & Products: Molecular Immunology (Book); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 388
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hennings, Henry
AU - Michael, Delores
AU - Lichti, Ulrike
AU - Yuspa, Stuart H.
T1 - Response of Carcinogen-Altered Mouse Epidermal Cells to Phorbol Ester Tumor Promoters and Calcium.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/01//
VL - 88
IS - 1
M3 - Article
SP - 60
EP - 65
SN - 0022202X
AB - Primary cultures of mouse epidermal cells are induced to terminally differentiate when extracellular calcium levels are increased to more than 0.1 mM After carcinogen treatment, cellular foci can be selected that resist this calcium signal to terminally differentiate Calcium causes these foci to stratify, however, in contrast to normal epidermis, DNA- synthesizing cells in these foci are found in the suprabasal cell layers as well as in basal cells Cell lines derived from these foci may be considered to be putative initiated cells Three of these cell lines, designated 308, D, and F, have been characterized for their response to calcium and phorbol ester tumor promoters. The formation of cornified cells and the activity of epidermal transglutaminase were utilized as markers of epidermal differentiation. Neither calcium nor the tumor promoter 12-O-tetradecanoylphorbol-13- acetate (TPA) increased transglutaminase activity or cornification of any of the 3 lines Proliferation was estimated by the [³H]thymidine labeling index, by incorporation of [³H]thymidine into DNA, and by a clonal growth assay. Unlike primary normal cultures, rising the calcium level of the medium did not markedly reduce the rate of proliferation of any of the 3 cell lines. in 2 of the lines, line 308 and line D, proliferation increased in response to TPA exposure. in line F, [³H]thymidine incorporation in confluent cultures was inhibited by TRA, while in cells plated at clonal densities, TPA was cytotoxic at doses of 5 ng/ml or higher. It these calcium-resistant epidermal cell lines correspond to initiated cells, their lack of sensitivity to the induction of terminal differentiation by TPA could account for their growth relative to normal cells. Those lines that also respond to stimulation of proliferation by TPA to a greater extent than normal cells would have a further growth advantage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENESIS
KW - EPIDERMIS
KW - CELLS
KW - EPITHELIUM
KW - PHORBOL esters
KW - COCARCINOGENS
KW - CALCIUM
N1 - Accession Number: 12465014; Hennings, Henry 1 Michael, Delores 1 Lichti, Ulrike 1 Yuspa, Stuart H. 1; Affiliation: 1: Vitro Pathogenesis Section, Laboratory of Cellular Carcínogenesis and Tumor Promotion, Nation Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A..; Source Info: Jan1987, Vol. 88 Issue 1, p60; Subject Term: CARCINOGENESIS; Subject Term: EPIDERMIS; Subject Term: CELLS; Subject Term: EPITHELIUM; Subject Term: PHORBOL esters; Subject Term: COCARCINOGENS; Subject Term: CALCIUM; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12465014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Masys, Daniel R.
AU - Hubbard, Susan M.
T1 - Technical Information Programs of the National Cancer Institute.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1987/01//
VL - 38
IS - 1
M3 - Article
SP - 60
EP - 64
SN - 00028231
AB - Since its founding in 1937, the National Cancer institute (NCI) has supported a substantial program of information dissemination. Two peer-reviewed journals, begun in 1940 and 1959, are supplemented by a congressionally mandated international Cancer Research Data Bank (ICRDB), established in 1972. The NCI has made available online databases of published cancer literature and cancer research in progress for the past decade, using the National Library of Medicine (NLM) MEDLARS system. Recently, a clinical-practice-oriented cancer-information system called Physician Data Query (PDQ) has been developed for access at the NLM, as well as through commercial database vendors. The impact of the NCI information programs is currently under prospective evaluation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIBRARIES
KW - ONLINE databases
KW - ONLINE data processing
KW - COMMUNICATION of technical information
KW - CANCER research
KW - PERIODICALS
N1 - Accession Number: 16771829; Masys, Daniel R. 1,2; Hubbard, Susan M. 1; Affiliations: 1: International Cancer Research Data Bank Branch, National Cancer Institute, Bethesda, MD 20892; 2: International Cancer Information Center, National Cancer Institute, Bethesda, MD 20892; Issue Info: Jan1987, Vol. 38 Issue 1, p60; Thesaurus Term: LIBRARIES; Thesaurus Term: ONLINE databases; Thesaurus Term: ONLINE data processing; Subject Term: COMMUNICATION of technical information; Subject Term: CANCER research; Subject Term: PERIODICALS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 519121 Libraries; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Crump, T
T1 - Scientific/technical translations in a research library
JO - Reference Librarian
JF - Reference Librarian
Y1 - 1987///Spr
IS - 17
M3 - Article
SP - 113
EP - 122
SN - 02763877
AB - This paper reviews the past use of the translation diary to aid the translator in library work. The author focuses on how libraries have helped to solve the types of problems recorded in the diary. A short bibliography is given on journals that are available in translation.
KW - REFERENCE services (Libraries)
KW - RESEARCH libraries
KW - Scientific information
KW - Technical information
N1 - Accession Number: ISTA2202445; Crump, T 1; Affiliations: 1 : National Institutes of Health Library, Bethesda, MD; Source Info: Spr 1987 Issue 17, p113; Note: Update Code: 2200; Subject Term: REFERENCE services (Libraries); Subject Term: RESEARCH libraries; Author-Supplied Keyword: Scientific information; Author-Supplied Keyword: Technical information; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2006-06444-063
AN - 2006-06444-063
AU - Tabakoff, Boris
T1 - How Alcohol Intoxicates.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/01//
VL - 32
IS - 1
SP - 77
EP - 77
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06444-063. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alcohol Intoxication; Biology; Neurochemistry. Minor Descriptor: Chemicals; Ethanol; Membranes; Proteins; Toxic Disorders. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: Hunt, Walter A. Alcohol and Biological Membranes=New York: Guilford Press, 1985. 214 pp. $25.00; 1985. Page Count: 1. Issue Publication Date: Jan, 1987.
AB - Reviews the book, Alcohol and Biological Membranes by Walter A. Hunt (1985). In Alcohol and Biological Membranes, Hunt addresses the enigma of how a molecule with so little inherent chemical information can produce the characteristic and extensive signs of alcohol intoxication. The volume is organized to demonstrate the 'ripple effect' of alcohol's actions, wherein minute perturbations of membrane order produced by ethanol are amplified through subsequent perturbations of the function of membrane proteins. There are several features that distinguish this book from prior attempts to catalog and interpret data relating to the molecular site of ethanol's actions. Another laudable feature of this volume is the clear effort of the author to avoid a dogmatic approach to interpretation of the multitude of experimental results. A reader who hopes this book will provide a clear understanding of alcohol's mechanisms of action will surely be disappointed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - biochemistry
KW - alcohol intoxication
KW - membrane proteins
KW - ethanol's actions
KW - chemicals
KW - 1987
KW - Alcohol Intoxication
KW - Biology
KW - Neurochemistry
KW - Chemicals
KW - Ethanol
KW - Membranes
KW - Proteins
KW - Toxic Disorders
KW - 1987
U2 - Hunt, Walter A. (1985); Alcohol and Biological Membranes; New York: Guilford Press, 1985. 214 pp. $25.00
DO - 10.1037/026701
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06444-063&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09762-008
AN - 2005-09762-008
AU - Marcus, Joseph
AU - Hans, Sydney L.
AU - Nagler, Shmuel
AU - Auerbach, Judith G.
AU - Mirsky, Allan F.
AU - Aubrey, Annie
T1 - Review of the NIMH Israeli Kibbutz-City Study and the Jerusalem Infant Development Study.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1987///
VL - 13
IS - 3
SP - 425
EP - 438
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Marcus, Joseph, 910 Chelham Way, Santa Barbara, CA, US, 93108
N1 - Accession Number: 2005-09762-008. PMID: 3629198 Partial author list: First Author & Affiliation: Marcus, Joseph; Unit for Research in Child Psychiatry and Development, University of Chicago, Chicago, IL, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20150914. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Infant Development; Offspring; Parents; Schizophrenia. Minor Descriptor: Perceptual Motor Processes; Social Skills. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: Israel. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Taylor Closure Test; Sarason General Anxiety Scale for Children; Schedule for Affective Disorders and Schizophrenia -Lifetime Version; Bender Gestalt Test; Sentence Completion Series; Social Adjustment Scale DOI: 10.1037/t32027-000; Thematic Apperception Test (TAT); Wechsler Adult Intelligence Scale (WAIS); Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 1987.
AB - The National Institute of Mental Health (NIMH) Israeli Kibbutz-City Study has followed the development of offspring of schizophrenic parents from middle childhood through early adulthood. During childhood, a subgroup of offspring of schizophrenic patients showed clear neurobehavioral deficits often accompanied by poor social competence. Early followup data suggest that this subgroup of high-risk children is at greatest risk for adult schizophrenia spectrum illness. The Jerusalem Infant Development Study has followed a similar population of children at risk for schizophrenia from before birth through middle childhood. A subgroup of high-risk children showed sensorimotor dysfunctioning in the first year of life, which was followed by perceptual, motor, and attentional dysfunctioning in childhood--identical to that found in the NIMH cohort. Results from both studies support the hypothesis that schizophrenic illness involves constitutional factors whose expression can be observed as early as infancy. Results also illustrate the importance of using data-analytic approaches that (1) look for subgroups within high-risk groups rather than only group differences between high- and low-risk groups, and (2) examine profiles of behavior rather than only single variables. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant development
KW - schizophrenic parents
KW - offsprings
KW - social competence
KW - neurobehavioral deficits
KW - at risk populations
KW - sensorimotor dysfunctioning
KW - 1987
KW - At Risk Populations
KW - Infant Development
KW - Offspring
KW - Parents
KW - Schizophrenia
KW - Perceptual Motor Processes
KW - Social Skills
KW - 1987
DO - 10.1093/schbul/13.3.425
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09762-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - BRANN, MARK R.
AU - COHEN, LESLIE V.
T1 - Diurnal Expression of Transducin mRNA and Translocation of Transducin in Rods of Rat Retina.
JO - Science
JF - Science
Y1 - 1987/01/30/
VL - 235
IS - 4788
M3 - Article
SP - 585
EP - 587
SN - 00368075
AB - The messenger RNA (mRNA) that encodes a subunit of the guanosine triphosphatebinding protein transducin (Tα) and Ta immunoreactivity were lli and measured in the rat retina during the light-dark cyde with in situ hybridization and immunohistochemistry. Both Tα mRNA and Tα immunoreactivity were observed only in photoreceptors. Within the photoreceptor Tα mRNA was present primarily in the inner segments and to a lesser extent in the outer nudear layer at all times during the day and night. However, the distribution of Tα immunoreactivity varied profoundly with the light-dark cycle; during the day, Tα immunoreactivity was highest in the inner segments, and at night the outer segments were more immunoreactive. The amounts of Tα mRNA and Tα immunoreactivity also depended on the light-dark cyde. Levels of Tα mRNA were high immediately before and after lights on; levels were low for the rest of the light-dark cyde. During the day, Ta immunoreactivity increased in the inner segments following the increase in Tα mRNA. After the lights were turned off, Ta immunoreactivity decreased in the inner segments and increased in the outer segments. Thus, it appears that Tα is synthesized in the inner segments after a morning increase in Ta mRNA. Newly synthcsized Tα remains in the inner segents until it is transported to the outer segments at night, where it may be involved in the increase in the sensitivity of photoreceptor rods at night. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461230; BRANN, MARK R. 1,2 COHEN, LESLIE V. 1; Affiliation: 1: Laboratory of Cell Biology, National Institute of Mental Health, Room 3A-17, Building 36, Bethesda, MD 20892 2: Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 9C-101, Building 10, Bethesda, MD 20892; Source Info: 1/30/1987, Vol. 235 Issue 4788, p585; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joffres, Michel R.
AU - Reed, Dwayne M.
AU - Yano, Katsuhiko
T1 - Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/02//
VL - 45
IS - 2
M3 - Article
SP - 469
EP - 475
SN - 00029165
AB - Associations between blood pressure and intakes of 61 dietary variables assessed by 24-h recall method were investigated in 615 men of Japanese ancestry living in Hawaii who had no history of cardiovascular disease or treated hypertension. Magnesium, calcium, phosphorus, potassium, fiber, vegetable protein, starch, vitamin C, and vitamin D intakes were significant variables that showed inverse associations with blood pressure in univariate and a multivariate analyses. Magnesium had the strongest association with blood pressure, which supports recent interest in its relation to blood pressure. Nevertheless, it was not possible to separate the effect of magnesium from that of other variables because of the problem of high intercorrelation among many nutrients. While recommendations based upon cross-sectional studies must be viewed cautiously, these results suggest that foods such as vegetables, fruits, whole grains, and low-fat dairy items are major sources of nutrients that may be protective against hypertension. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnesium in the body
KW - Blood pressure
KW - Cardiovascular diseases
KW - Hypertension
KW - Honolulu (Hawaii)
KW - magnesium
KW - nutrition
N1 - Accession Number: 91095377; Joffres, Michel R. 1; Reed, Dwayne M. 2; Yano, Katsuhiko 1; Affiliations: 1: Honolulu Heat Program, National Heart, Lung and Blood Institute, Honolulu, HI; 2: Kuakini Medical Center and the Honolulu Heart Program National Heart, Lung and Blood Institute, Honolulu, HI; Issue Info: Feb1987, Vol. 45 Issue 2, p469; Subject Term: Magnesium in the body; Subject Term: Blood pressure; Subject Term: Cardiovascular diseases; Subject Term: Hypertension; Subject: Honolulu (Hawaii); Author-Supplied Keyword: magnesium; Author-Supplied Keyword: nutrition; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SorIie, Paul D.
AU - Gold, Ellen B.
T1 - The Effect of Physician Terminology Preference on Coronary Heart Disease Mortality: An Artifact Uncovered by the 9th Revision ICD.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/02//
VL - 77
IS - 2
M3 - Article
SP - 148
EP - 152
PB - American Public Health Association
SN - 00900036
AB - We dual coded 2,268 deaths due to heart disease occurring in Maryland, using the 8th and 9th revisions of the International Classification of Diseases (ICDA-8, Adapted for Use in the United States, and ICD-9). Certifier preference was for generalized cardiovascular terms rather than terms specific to the heart, resulting in an artifactual change in chronic ischemic heart disease death (IHD) rates in Maryland between 1978 and 1979 because the 8th and 9th ICD revisions classified these terms differently. Medical examiners were more likely to use these generalized cardiovascular terms as were physicians who went to certain medical schools in the state. The physician's terminology preference was associated with the sex and race of the decedent and was related to aspects of the patient's medical care. The ICD should be modified in the 10th revision to allow for the separate classification of generalized cardiovascular terminology within the ischemic heart disease category. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Research
KW - MEDICAL terminology
KW - MEDICAL screening
KW - CORONARY heart disease
KW - CARDIOVASCULAR diseases
KW - HEART diseases
KW - PERIODIC health examinations
KW - PHYSICIAN & patient
KW - MORTALITY
KW - MARYLAND
N1 - Accession Number: 4949698; SorIie, Paul D. 1 Gold, Ellen B. 2; Affiliation: 1: National Institutes of Health, National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Federal Building, Room 3A-10, Bethesda, MD 20892 2: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore; Source Info: Feb1987, Vol. 77 Issue 2, p148; Subject Term: MEDICAL care -- Research; Subject Term: MEDICAL terminology; Subject Term: MEDICAL screening; Subject Term: CORONARY heart disease; Subject Term: CARDIOVASCULAR diseases; Subject Term: HEART diseases; Subject Term: PERIODIC health examinations; Subject Term: PHYSICIAN & patient; Subject Term: MORTALITY; Subject Term: MARYLAND; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Riley, Matilda White
T1 - ON THE SIGNIFICANCE OF AGE IN SOCIOLOGY.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1987/02//
VL - 52
IS - 1
M3 - Article
SP - 1
EP - 14
SN - 00031224
AB - A sociology of age provides an analytical framework for understanding the interplay between human lives and changing social structures. Its mission is to examine the interdependence between (1) aging over the life course as a social process and (2) societies and groups as stratified by age, with the succession of cohorts as the link connecting the two. This special field of age draws on sociology as a whole and contributes to it through reformulation of traditional emphases on process and change, on the multiple interdependent levels of the system, and on the multidimensionality of sociological concerns as they touch on related aspects of other disciplines. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Sociological Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGING
KW - SOCIAL psychology
KW - SOCIAL structure
KW - HUMAN life cycle
KW - SOCIAL stratification
KW - SOCIOLOGICAL research
N1 - Accession Number: 14773623; Riley, Matilda White 1; Affiliation: 1: National institutes of Health.; Source Info: Feb87, Vol. 52 Issue 1, p1; Subject Term: AGING; Subject Term: SOCIAL psychology; Subject Term: SOCIAL structure; Subject Term: HUMAN life cycle; Subject Term: SOCIAL stratification; Subject Term: SOCIOLOGICAL research; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolfe, Mary D.
AU - Carlos, James P.
T1 - Periodontal disease in adolescents: epidemiologic findings in Navajo Indians.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1987/02//
VL - 15
IS - 1
M3 - Article
SP - 33
EP - 40
SN - 03015661
AB - A cross-sectional epidemiologic survey was conducted of 618 Navajo Indians, aged 14-19,. resident in a boarding school in New Mexico. Periodontal status was assessed by clinical measurements of attachment level and gingival bleeding, and evidence of alveolar bone loss from standardized bitewing radiographs. Attachment level and gingival bleeding were measured at 24 posterior interproximal sites (six sites in each quadrant): the mesio-buccal aspect of the second molar; the disto-buccal and mesio-buccal aspects of the first molar and second premolar; and the disto-buccal aspect of the first premolar. Alveolar bone level was measured from radiographs at the corresponding approximal surfaces of the same teeth. Attachment loss was considered present when the distance from the CEJ to the base of the pocket was > 1 mm; bone loss was considered present when the radiographic distance from the CEJ to the alveolar crest was > 2 mm, and gingival bleeding was considered present if bleeding occurred immediately after gentle probing. Attachment loss was evident at one or more sites in 88.7% of the population, 45.9% of the subjects had attachment loss at eight or more sites, and 101 subjects (16.3%) had one or more sites with at least 4.0 mm of attachment loss. Bone loss was present at one or more sites in 89.2% of the population, 28.6% had eight or more affected sites, and 4.7% (29 subjects) had one or more sites with at least 2.0 mm of bone loss. Gingival bleeding was evident at one or more sites in 70.6% of the population, and 19.7% had eight or more affected sites. None of the conditions were strongly associated with sex, but the prevalence of bone loss increased with age. The prevalence and severity of incipient periodontitis seemed much higher in these subjects than previously reported in other adolescent groups when similar diagnostic criteria and methods of measurement were used. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTAL disease
KW - PERIODONTICS
KW - GUM disease
KW - EPIDEMIOLOGY
KW - GINGIVITIS
KW - MEXICO
KW - adolescence
KW - epidemiology
KW - Indians
KW - North American: Navajo
KW - oral
KW - periodontal diseases
N1 - Accession Number: 12038976; Wolfe, Mary D. 1 Carlos, James P. 1; Affiliation: 1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Feb1987, Vol. 15 Issue 1, p33; Subject Term: PERIODONTAL disease; Subject Term: PERIODONTICS; Subject Term: GUM disease; Subject Term: EPIDEMIOLOGY; Subject Term: GINGIVITIS; Subject Term: MEXICO; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: Indians; Author-Supplied Keyword: North American: Navajo; Author-Supplied Keyword: oral; Author-Supplied Keyword: periodontal diseases; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1600-0528.ep12038976
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hintner, Helmut
AU - Romani, Nikolaus
AU - Stanzl, Ursula
AU - Grubauer, Gerhard
AU - Fritsch, Peter
AU - Lawley, Thomas J.
T1 - Phagocytosis of Keratin Filament Aggregates Following Opsonization With IgG-Anti-Keratin Filament Autoantibodies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/02//
VL - 88
IS - 2
M3 - Article
SP - 176
EP - 182
SN - 0022202X
AB - IgG-anti-keratin intermediate filament autoantibodies occur in low titers in all normal human sera. These same antibodies are present in high titers in the sera of patients who have diseases in which cells containing keratin intermediate filaments (KIF) have been damaged, such as systemic lupus erythematosus, graft-versus-host disease, and cutaneous tumors. Since some human autoantibodies are thought to function in part as opsonins promoting the removal of insoluble cellular proteins after tissue injury, we investigated the influence of IgG-anti-KIF autoantibodies on the phagocytosis of insoluble KIF aggregates by human monocytes and polymorphonuclear neutrophils (PMN). Keratin intermediate filaments assembled in vitro were reconstituted into dense spherical KIF aggregates 0.3-2.5 μm in diameter by dialysis against phosphate-buffered saline. Immunoelectron microscopy revealed that, as expected, human IgG-anti-KIF autoantibodies bound to the KIF aggregates. Human monocytes or PMN were incubated either with nonopsonized KIF aggregates or with KIF aggregates that had been reacted with IgG-anti-KIF autoantibodies. The uptake of KIF aggregates was visualized by indirect immunofluorescence, immunoperoxidase staining, and immunoelectron microscopy. Monocytes rapidly and efficently bound and phagocy tosed KIF aggregates that had ben coated with IgG-anti-KIF autoantibodies. Nonopsonized KIF Agregates, in contrast, were taken up much less efficiently. Differences were most marked at 4°C for 60 min with phagocytosis of opsonized KIF aggregates by 23 ± 8% of monocytes in contrast to phagocytosis by only 0.2 ± 3% monocyted in contrast to phagocytosis when nonopsonized KIF aggregates were used. Similar results occurred at 37°C for 5 min with phagocytosis by 38 ± 28% vs 1.8 ± 0.4% of monocytes of opsonized and nonopsonized KIF aggregates, respectively. A high percentage of PMN also phagocytosed opsonized KIF aggregates, whereas nonopsonized KIF aggregates wereingested less avidly. These data indicate that the opsonization of extracellular KIF aggregates by IgG-anti-KIF autoantiobodies plays an important role in promoting the phagocytosis of KIF aggregates. The subsequent phagocytosis represents a rapid and very effectivemechanism for the removal of insoluble KIF following keratinocyte cell death. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHAGOCYTOSIS
KW - KERATIN
KW - IMMUNOGLOBULIN G
KW - AUTOANTIBODIES
KW - IMMUNE response
KW - SERUM
N1 - Accession Number: 12525322; Hintner, Helmut 1 Romani, Nikolaus 1 Stanzl, Ursula 1 Grubauer, Gerhard 1 Fritsch, Peter 1 Lawley, Thomas J. 2; Affiliation: 1: Department of Dermatology, University of Innsbruck, Innsbruck, Austria. 2: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb87, Vol. 88 Issue 2, p176; Subject Term: PHAGOCYTOSIS; Subject Term: KERATIN; Subject Term: IMMUNOGLOBULIN G; Subject Term: AUTOANTIBODIES; Subject Term: IMMUNE response; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525322
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tschachler, Erwin
AU - Groh, Veronika
AU - Popovic, Mikulas
AU - Mann, Dean L.
AU - Konrad, Klaus
AU - Safai, Bijan
AU - Eron, Lawrence
AU - DiMarzo Veronese, Fulvia
AU - Wolff, Klaus
AU - Stingl, Georg
T1 - Epidermal Langerhans Cells-A Target for HTLV-III/LAV Infection.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/02//
VL - 88
IS - 2
M3 - Article
SP - 233
EP - 237
SN - 0022202X
AB - Langerhans cells (LC) are bone marrow-derived, la+, CD1+, CD4+, ATPase+ dendritic antigen-presenting cells within the human epidermis. Since the CD4 molecule has been implicated as a receptor structure for HTLV-III/LAV (human T-cell leukemia virus/lymphadenopathy-associated virus), we asked whether LC from HTLV-III/LAV-seropositive individuals display signs of HTLV-III/LAV infection. In skin biopsies from 7/40 HTLV-III/LAV-infected persons (1 asymptomatic carrier, 2 patients with acquired immunodeficiency syndrome (AIDS)-related complex and 4 patients with AIDS), LC were the only epidermal cells to react with a monoclonal antibody specific for the HTLV-III core protein p17. A varying percentage of p17+ LC were morphologically altered with blunt dendrites and poorly demarcated cellular contours. In one of these biopsies, the presence of LC-associated viral particles characteristic of HTLV-III/LAV as well as cytopathic changes in approximately one-third of the LC population were demonstrated by electron microscopy. These results strongly suggest that LC may harbor HTLV-III/LAV. The infection of LC with this retrovirus may have deleterious consequences for the immunologic functions of this cell system and may thus contribute to both the acquisition of immunodeficiency and the infectious and neoplastic complications of AIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS patients
KW - LANGERHANS cells
KW - EPIDERMIS
KW - HIV infections
KW - IMMUNE system
KW - CD4 antigen
N1 - Accession Number: 12525402; Tschachler, Erwin 1 Groh, Veronika 1 Popovic, Mikulas 2 Mann, Dean L. 3 Konrad, Klaus 1 Safai, Bijan 4 Eron, Lawrence 5 DiMarzo Veronese, Fulvia 6 Wolff, Klaus 1 Stingl, Georg 1,7; Affiliation: 1: Department of Dermatology I, University of Vienna Medical School, Vienna, Austria. 2: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 3: Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 4: Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York. 5: Infectious Disease Section, Fairfax Hospital, Falls Church, Virginia. 6: Department of Cell Biology, Litton Bionetics, Inc., Kensington, Maryland. 7: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb87, Vol. 88 Issue 2, p233; Subject Term: AIDS patients; Subject Term: LANGERHANS cells; Subject Term: EPIDERMIS; Subject Term: HIV infections; Subject Term: IMMUNE system; Subject Term: CD4 antigen; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525402
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06445-068
AN - 2006-06445-068
AU - Shah, Saleem A.
T1 - Mental Health Aspects of Violence.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/02//
VL - 32
IS - 2
SP - 185
EP - 186
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06445-068. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Criminal Behavior; Domestic Violence; Mental Health; Suicide; Violence. Minor Descriptor: History. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Aronowitz, Eugene (Ed); Sussman, Robert (Ed). Mental Health and Violence=Canton, MA: Prodist, 1985. 129 pp. $6.95 paperback; 1985. Page Count: 2. Issue Publication Date: Feb, 1987.
AB - Reviews the book, Mental Health and Violence edited by Eugene Aronowitz and Robert Sussman (1985). This book consists of presentations made on that occasion, as well as some additional material. It is not entirely clear what audiences the editors had in mind when they decided to publish this compilation. The presentations in this volume cover such topics as sources of violence in American history, domestic or family violence, child sexual abuse and incest, criminal violence, suicidal behavior in children, adolescents and adults, and drug abuse considered as inwardly directed violence. This volume also displays much variation even in the citation and reference styles used by the numerous contributors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - violence
KW - criminal violence
KW - American history
KW - suicidal behavior
KW - 1987
KW - Criminal Behavior
KW - Domestic Violence
KW - Mental Health
KW - Suicide
KW - Violence
KW - History
KW - 1987
U2 - Aronowitz, Eugene (Ed); Sussman, Robert (Ed). (1985); Mental Health and Violence; Canton, MA: Prodist, 1985. 129 pp. $6.95 paperback
DO - 10.1037/026814
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Blot, William J.
AU - Fraumeni, Joseph F.
T1 - Trends in Esophageal Cancer Mortality among US Blacks and Whites.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/03//
VL - 77
IS - 3
M3 - Article
SP - 296
EP - 298
PB - American Public Health Association
SN - 00900036
AB - Abstract: National age-adjusted rates of mortality from esophageal cancer have increased among Blacks in the United States. while remaining nearly unchanged among Whites. By 1980, esophageal cancer had become one of the leading causes of cancer death among Blacks, with the excess among males under age 55 exceeding six-fold. Inferences about the causes of esophageal cancer cannot be made from this descriptive survey, but the rising trend raises etiologic hypotheses about environmental exposures (e.g., alcohol tobacco nutrition) that may differentially affect Blacks. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESOPHAGEAL cancer
KW - CANCER -- Mortality
KW - CANCER patients
KW - MORTALITY
KW - AFRICAN Americans -- Diseases
KW - AFRICAN Americans -- Mortality
KW - HEALTH behavior
KW - HEALTH surveys
KW - UNITED States
N1 - Accession Number: 4949757; Blot, William J. 1 Fraumeni, Joseph F. 2; Affiliation: 1: Chief, Biostatistics Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892 2: Associate Director of the Program, Biostatistics Branch, Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892; Source Info: Mar1987, Vol. 77 Issue 3, p296; Subject Term: ESOPHAGEAL cancer; Subject Term: CANCER -- Mortality; Subject Term: CANCER patients; Subject Term: MORTALITY; Subject Term: AFRICAN Americans -- Diseases; Subject Term: AFRICAN Americans -- Mortality; Subject Term: HEALTH behavior; Subject Term: HEALTH surveys; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaplan, George A.
AU - Seeman, Teresa E.
AU - Cohen, Richard D.
AU - Knudsen, Lisa P.
AU - Guralnik, Jack
T1 - Mortality among the Elderly in the Alameda Country Study: Behavioral and Demographic Risk Factors.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/03//
VL - 77
IS - 3
M3 - Article
SP - 307
EP - 312
PB - American Public Health Association
SN - 00900036
AB - Abstract: We studied the association between behavioral and demographic risk factors and 17-year mortality in members of the Alameda County (California) Study who were 60-94 years of age at baseline. In this age group, increased risk of death is associated with being male. smoking, having little leisure-time physical activity, deviating from moderate weight relative to height, and not regularly eating breakfast. These increased risks were independent of age, race, socioeconomic position (SEP), other behavioral risk factors, and baseline physical health status. Further examination of the group aged 70 or more revealed the same patterns of heightened risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - BEHAVIORAL assessment
KW - HEALTH status indicators
KW - MORTALITY
KW - HUMAN behavior
KW - DEATH -- Psychological aspects
KW - BEREAVEMENT -- Psychological aspects
KW - PHYSICAL fitness for older people
KW - ALAMEDA County (Calif.)
KW - CALIFORNIA
N1 - Accession Number: 4949767; Kaplan, George A. 1 Seeman, Teresa E. 2 Cohen, Richard D. 3 Knudsen, Lisa P. 3 Guralnik, Jack 4; Affiliation: 1: Human Population Laboratory California Department of Health Services, 2151 Berkeley Way, Annex 2, Room 211, Berkeley, CA 94704-9980 2: Department of Epidemiology and Public Health, Yale University 3: HPL 4: National Institute on Aging/NIH, Bethesda, MD; Source Info: Mar1987, Vol. 77 Issue 3, p307; Subject Term: HEALTH risk assessment; Subject Term: BEHAVIORAL assessment; Subject Term: HEALTH status indicators; Subject Term: MORTALITY; Subject Term: HUMAN behavior; Subject Term: DEATH -- Psychological aspects; Subject Term: BEREAVEMENT -- Psychological aspects; Subject Term: PHYSICAL fitness for older people; Subject Term: ALAMEDA County (Calif.); Subject Term: CALIFORNIA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Magrath, Ian T.
T1 - IMMUNOGENETICS.
JO - BioScience
JF - BioScience
Y1 - 1987/03//
VL - 37
IS - 3
M3 - Book Review
SP - 228
EP - 229
SN - 00063568
AB - Reviews the book "Immunogenics: Its Application to Clinical Medicine," edited by Takehiko Sasazuki and Tomio Tadi.
KW - Immunology
KW - Nonfiction
KW - Immunogenics (Book)
N1 - Accession Number: 10102222; Magrath, Ian T. 1; Affiliations: 1: Senior Investigator, Pediatric Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892; Issue Info: Mar1987, Vol. 37 Issue 3, p228; Thesaurus Term: Immunology; Subject Term: Nonfiction; Reviews & Products: Immunogenics (Book); Number of Pages: 2p; Illustrations: 1 Cartoon or Caricature; Document Type: Book Review; Full Text Word Count: 886
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Suwalsky, Joan T.D.
AU - Klein, Robert P.
AU - Zaslow, Martha J.
AU - Rabinovich, Beth A.
AU - Gist, Nancy F.
T1 - Dimensions of Naturally Occurring Mother-Infant Separations During the First Year of Life.
JO - Infant Mental Health Journal
JF - Infant Mental Health Journal
Y1 - 1987///Spring87
VL - 8
IS - 1
M3 - Article
SP - 3
EP - 18
PB - John Wiley & Sons, Inc.
SN - 01639641
AB - The goals of this paper are (1) to introduce a methodology developed to study mother-infant separations that occur in the context of normal family life, including but going beyond separations associated with maternal employment; (2) to present illustrative data that describe the range of separations experienced by one sample of infants; and (3) to demonstrate how a focus on specific underlying dimensions results in a more precise characterization of the separation experience. It is necessary to identify the specific dimensions on which mother-infant separations vary in order to clarify which aspects of separation are relevant to child outcome. Detailed histories of mother-infant separations and concomitant substitute care during the first year of life ware obtained by interview from 144 middle-class mothers of first-born infants. Far from being an unusual event, separation from mother was a normal experience during infancy for this sample. Six types of separation were identified, the majority of which have not been studied previously. Analyses indicated that naturally occurring mother-infant separations can be differentiated statistically and compared in terms of amount of separation, stability of care, characteristics of caregivers, and characteristics of the substitute care setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Infant Mental Health Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOTHER & infant
KW - SEPARATION anxiety in infants
KW - FAMILIES
KW - FAMILY relations
KW - EMPLOYMENT (Economic theory)
KW - WORKING mothers
KW - CHILD development
KW - WORK & family
KW - INFANTS -- Care
KW - SEPARATION (Psychology)
N1 - Accession Number: 12035318; Suwalsky, Joan T.D. 1 Klein, Robert P. 1 Zaslow, Martha J. 1 Rabinovich, Beth A. 1 Gist, Nancy F. 1; Affiliation: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Source Info: Spring87, Vol. 8 Issue 1, p3; Subject Term: MOTHER & infant; Subject Term: SEPARATION anxiety in infants; Subject Term: FAMILIES; Subject Term: FAMILY relations; Subject Term: EMPLOYMENT (Economic theory); Subject Term: WORKING mothers; Subject Term: CHILD development; Subject Term: WORK & family; Subject Term: INFANTS -- Care; Subject Term: SEPARATION (Psychology); Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - George, David T.
AU - Weiss, Sandra R.
AU - Gwirtsman, Harry E.
AU - Blazer, Dan
T1 - Hospital Treatment of Anorexia Nervosa: A 25 Year Retrospective Study from 1958 to 1982.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 1987/03//
VL - 6
IS - 2
M3 - Article
SP - 321
EP - 330
PB - John Wiley & Sons, Inc.
SN - 02763478
AB - In order to characterize changes in the presenting symptomatology and treatment of anorexia nervosa (AN), the hospital charts of 76 anorexia nervosa patients were reviewed form three time periods: (I) 1958–1962, (II) 1969–1972, and (III) 1978–1982. in period I, 92% of the patient were admitted to a medicines service, whereas in period III, 92% were admitted to psychiatry. Age of onset, percent mean weight for height upon admission, and reported frequencies of laxative use and vomiting showed no statistical differences among the periods. Length of hospital stay and weight gained during hospitalization increased significantly during period III, with similar stays occurring for both vomiters and restrictors. Between periods I and III the number of medical diagnostic studies decreased while the frequency of behavioral therapies and use of antidepressant medication increased. During the past 25 years, theories of etiology and approaches to treatment of anorexia nervosa have become increasingly psychiatric. We postulate that the apparent increasing incidence of AN may partially be attributable to an underdiagnosis of AN by medical services in the past. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANOREXIA nervosa
KW - APPETITE loss
KW - EATING disorders
KW - PATIENTS
KW - APPETITE disorders
KW - HOSPITAL care
KW - PSYCHIATRY
KW - SYMPTOMS
KW - PATHOLOGICAL psychology
N1 - Accession Number: 12056246; George, David T. 1 Weiss, Sandra R. 1 Gwirtsman, Harry E. 2 Blazer, Dan 3; Affiliation: 1: National Institute of Mental Health, Section on Biomedical Psychiatry, Laboratory of Clinical Science, Bethesda, Maryland 2: UCLA Neuropsychiatric Institute, Los Angeles, California 3: Duke University, Durham, North Carolina; Source Info: Mar1987, Vol. 6 Issue 2, p321; Subject Term: ANOREXIA nervosa; Subject Term: APPETITE loss; Subject Term: EATING disorders; Subject Term: PATIENTS; Subject Term: APPETITE disorders; Subject Term: HOSPITAL care; Subject Term: PSYCHIATRY; Subject Term: SYMPTOMS; Subject Term: PATHOLOGICAL psychology; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor, Edward H.
T1 - The Biological Basis of Schizophrenia.
JO - Social Work
JF - Social Work
Y1 - 1987/03//Mar/Apr87
VL - 32
IS - 2
M3 - Article
SP - 115
PB - Oxford University Press / USA
SN - 00378046
AB - The article presents a study which considered the biological basis of schizophrenia. As part of the study the neurological changes in persons with schizophrenia are observed. Techniques adopted in the diagnosis of the mental illness are elaborated in the article. Assessment of the role of family environments in the acquisition of the illness is further undertaken. Neuropsychiatric studies using modem brain imaging techniques are rapidly redefining schizophrenia. Physical and chemical changes found In the brain have largely discredited beliefs that environment, attachment family interactions, or stress cause schizophrenia. Combining the new biological knowledge with methods of social work practice is of immediate importance, especially when one considers the number of individuals who suffer from schizophrenia and the number of families that are affected by a member's illness. In this context Researchers at the National Institute of Mental Health (MMII) have classified schizophrenia as a group of brain disease.
KW - SCHIZOPHRENIA
KW - MENTAL illness
KW - PATHOLOGICAL psychology
KW - SCHIZOTYPAL personality disorder
KW - BRAIN diseases
KW - DEVELOPMENTAL disabilities
N1 - Accession Number: 5271069; Taylor, Edward H. 1; Affiliation: 1: Clinical and Research Social Worker, Neuropsychiatric Branch, National Institute of Mental Health, W A. White Building, Saint Elizabeths Hospital, Washington, DC 20032.; Source Info: Mar/Apr87, Vol. 32 Issue 2, p115; Subject Term: SCHIZOPHRENIA; Subject Term: MENTAL illness; Subject Term: PATHOLOGICAL psychology; Subject Term: SCHIZOTYPAL personality disorder; Subject Term: BRAIN diseases; Subject Term: DEVELOPMENTAL disabilities; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SEGUIN, CARL
AU - HAMER, DEAN H.
T1 - Regulation in Vitro of Metallothionein Gene Binding Factors.
JO - Science
JF - Science
Y1 - 1987/03/13/
VL - 235
IS - 4794
M3 - Article
SP - 1383
EP - 1387
SN - 00368075
AB - Mouse nuclear factors that bind to an upstream metal regulatory element of the mouse metallothionein-I gene have been identified by DNA footprinting and oligonucleotide band shift assays. The formation of complexes at this site can be activated 20- to 40- fold by the in vitro addition of ionic cadmium. The activation reaction is rapid, reversible by a metal chelator, and may involve multiple proteins. These results suggest that the initial step in cadmium detoxification is an interaction between the metal and nuclear DNA-binding factors leading to an increase in metallothionein gene transcription. The ability to observe meal activation in vitro makes this a powerful system to study the biochemistry of eukaryotic gene regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461279; SEGUIN, CARL 1 HAMER, DEAN H. 2; Affiliation: 1: Molecular Endocrinology Laboratory, Laval University Medical Center, Ste. Fosy, Quebec, Canada G1V4GZ 2: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892; Source Info: 3/13/1987, Vol. 235 Issue 4794, p1383; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aerts, Johannes M. F. G.
AU - Donker-Koopman, Wilma E.
AU - Van Laar, Coos
AU - Brul, Stanley
AU - Murray, Gary J.
AU - Wenger, David A.
AU - Barranger, John A.
AU - Tager, Joseph M.
AU - Schram, André W.
T1 - Relationship between the two immunologically distinguishable forms of glucocerebrosidase in tissue extracts.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/03/16/
VL - 163
IS - 3
M3 - Article
SP - 583
EP - 589
PB - Wiley-Blackwell
SN - 00142956
AB - Extracts of human spleen contain two immunologically distinguishable forms of glucocerebrosidase: form I is precipitable by polyclonal or monoclonal anti-(placental glucocerebrosidase) antibodies, whereas form II is not [Aerts, J. M. F. G., Donker-Koopman, W. E., Van der Vliet, M. F. K., Jonsson, L. M. V., Ginns, E. I., Murray, G. J., Barranger, J. A., Tager, J. M. & Schram, A. W. (1985) Fur. J. Biochem. 150, 565-574]. The proportion of form II glucocerebrosidase was high in extracts of spleen, liver and kidney and low in extracts of brain, placenta and fibroblasts. Furthermore, the proportion of form II enzyme was higher in a detergent-free aqueous extract of spleen than in a Triton X-100 extract of total spleen or splenic membranes. When form II ghicocerebrosidase in a splenic extract was separated from form I enzyme by immunoaffinity chromatography and stored at 4°C, a gradual conversion to form I enzyme occurred. The conversion was almost immediate if 30% (v/v) ethylene glycol was present. In the denatured state both forms of glucocerebrosidase reacted with anti-(placental glucocerebrosidase) antibodies. Form I glucocerebrosidase was stimulated by sodium taurocholate or sphingolipid-activator protein 2 (SAP-2), whereas form II enzyme exhibited maximal activity in the absence of the effectors. The pH activity profile of form II glucocerebrosidase was almost identical to that of form I enzyme in the presence of SAP-2. In the native state, form I glucocerebrosidase had a molecular mass of 60 kDa whereas that of form II glucocerebrosidase was about 200 kDa. After gel-permeation high-performance liquid chromatography of splenic extracts, the fractions with form II glucocerebrosidase contained material cross-reacting with both anti-(placental glucocerebrosidase) and anti-(SAP-2) antibodies. Preincubation of form I glucocerebrosidase with SAP-2 at pH 4.5 led to masking of the epitope on glucocerebrosidase... [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUE extracts
KW - SPLEEN -- Physiology
KW - IMMUNOGLOBULINS
KW - SPHINGOLIPIDS
KW - MONOCLONAL antibodies
N1 - Accession Number: 13919009; Aerts, Johannes M. F. G. 1 Donker-Koopman, Wilma E. 1 Van Laar, Coos 1 Brul, Stanley 1 Murray, Gary J. 2 Wenger, David A. 3 Barranger, John A. 2 Tager, Joseph M. 1 Schram, André W. 1; Affiliation: 1: Laboratory of Biochemistry, University of Amsterdam 2: Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 3: Department of Pediatrics C233, University of Colorado School of Medicine, Denver; Source Info: 3/16/87, Vol. 163 Issue 3, p583; Subject Term: TISSUE extracts; Subject Term: SPLEEN -- Physiology; Subject Term: IMMUNOGLOBULINS; Subject Term: SPHINGOLIPIDS; Subject Term: MONOCLONAL antibodies; Number of Pages: 7p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mattson, Margaret E.
AU - Pollack, Earl S.
AU - Cullen, Joseph W.
T1 - What Are the Odds that Smoking Will Kill You?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/04//
VL - 77
IS - 4
M3 - Article
SP - 425
EP - 431
PB - American Public Health Association
SN - 00900036
AB - Abstract: We calculated the long-term risks of death from smoking for individuals of various ages and smoking status in terms of the excess mortality contributed by smoking, over and above the baseline mortality from the same diseases caused by factors other than smoking using standard life table procedures. Since mortality data for specific smoking categories were available only From prospective studies in the late 1950s, we scaled these to the 1982 mortality levels. We assumed, for lung cancer, that the death rates for nonsmokers have not changed and, for other smoking-related diseases, that the risks of death for smokers relative to those for nonsmokers have not changed since the 1950s. Probabilities that result from alternative assumptions were also investigated and are presented. As many as one-third of heavy smokers age 35 will die before age 85 of diseases caused by their smoking. The probabilities of death from smoking when compared with other causes may be persuasive as public education tools. Their effective use for this purpose is affected not only by the deficiencies in the public's factual knowledge of the magnitude of the risks from smoking, but also by numerous apparent misconceptions relating to the interpretation of risk information. Risk data should be presented to the public in a manner thru clarifies these misconceptions and facilitates their understanding of the overwhelming risk imposed by smoking. (Am J Public Health 1987; 77:425-431.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - ORAL habits
KW - LUNGS -- Cancer
KW - MORTALITY -- Statistics
KW - HEALTH risk assessment
KW - PUBLIC health
KW - HEALTH & welfare funds
KW - HEALTH status indicators
KW - PREVENTIVE medicine
N1 - Accession Number: 4949557; Mattson, Margaret E. 1 Pollack, Earl S. Cullen, Joseph W.; Affiliation: 1: Special Assistant for Research, Division of Cancer Prevention and Control, National Cancer Institute, Building 31, Room 4A46, 9000 Rockville Pike, Bethesda, MD 20892; Source Info: Apr87, Vol. 77 Issue 4, p425; Subject Term: SMOKING; Subject Term: ORAL habits; Subject Term: LUNGS -- Cancer; Subject Term: MORTALITY -- Statistics; Subject Term: HEALTH risk assessment; Subject Term: PUBLIC health; Subject Term: HEALTH & welfare funds; Subject Term: HEALTH status indicators; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Albanes, Demetrius
AU - Jones, D. Yvonne
AU - Micozzi, Marc S.
AU - Mattson, Margaret E.
T1 - Associations between Smoking and Body Weight in the US Population: Analysis of NHANES II.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/04//
VL - 77
IS - 4
M3 - Article
SP - 439
EP - 444
PB - American Public Health Association
SN - 00900036
AB - Abstract: Recent recommendations for increases in desirable body weights are based upon studies which did not consider the potential confounding effect of cigarette consumption on body weight. We investigated the relation between tobacco use and several anthropometric measurements in 12.103 men and women 19-74 years of age in the United States examined between 1976 and 1980 during the Second National Health and Nutrition Examination Survey (NHANES II). Cigarette smokers weighed less (mean +/standard error = 69.8 +/- 0.2 kg) and were leaner (body mass index (weight (kg)/height (m)²) = 24.6 +/- 0.1) than nonsmokers (72.5 +/- 0.2 kg and 25.7 +/- 0.1, respectively), controlling for age and sex. Body leanness increased with the duration (but not intensity) of smoking. Ex-smokers were not heavier or fatter than nonsmokers, and these groups experienced similar weight gain after age 25 (approximately 6 kg in men, 9 kg in women), while current smokers gained substantially less weight (3.5 kg in men, 5.4 kg in women). Compared to nonsmokers, former and current smokers were also slightly taller, Most of these associations were evident in both sexes and all ages evaluated, and were not explained by differences in caloric intake, physical activity, illness, or socioeconomic status, Our findings suggest that the increased mortality observed among lean individuals in previous studies may have been due to smoking rather than leanness per se, and that as a result, currently accepted desirable body weights may be overestimated. (Am J Public Health 1987: 77:439-444.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - BODY weight -- Regulation
KW - CIGARETTE smokers
KW - NICOTINE addiction
KW - SMOKING
KW - BODY mass index
KW - WEIGHT measurement
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 4949559; Albanes, Demetrius 1 Jones, D. Yvonne 1 Micozzi, Marc S. 1 Mattson, Margaret E. 1; Affiliation: 1: Cancer Prevention Studies Branch, and Office of the Director, Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Apr87, Vol. 77 Issue 4, p439; Subject Term: HEALTH surveys; Subject Term: BODY weight -- Regulation; Subject Term: CIGARETTE smokers; Subject Term: NICOTINE addiction; Subject Term: SMOKING; Subject Term: BODY mass index; Subject Term: WEIGHT measurement; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Feldman, A
T1 - High output quality with quick input of chemical structures
JO - Chemical Information Bulletin
JF - Chemical Information Bulletin
Y1 - 1987///Sum
VL - 39
IS - 2
M3 - Article
SP - 46
EP - 46
SN - 03641929
AB - To avoid coding errors, chemical structures are usually entered into a computer in graphic form. To increase speed, such diagrams may be distorted. In the NCI system--which the author believes to be the fastest--distortion occurs because of the requirements that all bonds fit within multiples of character spaces, and that Luhn dots represent carbon atoms in rings. While such diagrams are suitable for error checking, they cannot be used in publications. To achieve a traditional, esthetically pleasing output, the author has embedded a conversion algorithm in the routines that format hard-copy output. The algorithm removes the Luhn dots by extending the bonds, and translates atoms and bonds from the original grid to a finer one. The illustrations show the appearance of a structure following input and as output. Under this transformation, any implied stereochemistry is retained.
KW - Chemical data
KW - Encoding
KW - Input
KW - Output
N1 - Accession Number: ISTA2202842; Feldman, A 1; Affiliations: 1 : National Cancer Institute, Bethesda, MD; Source Info: Sum 1987, Vol. 39 Issue 2, p46; Note: Update Code: 2200; Author-Supplied Keyword: Chemical data; Author-Supplied Keyword: Encoding; Author-Supplied Keyword: Input; Author-Supplied Keyword: Output; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Mizuma, H.
AU - Zolla-Pazner, Susan
AU - Litwin, S.
AU - Wafaa El-Sadr
AU - Sharpe, Sandra
AU - Zehr, B.
AU - Weiss, S.
AU - Saxinger, W.C.
AU - Marmor, M-
T1 - Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/04//
VL - 68
IS - 1
M3 - Article
SP - 5
EP - 14
PB - Wiley-Blackwell
SN - 00099104
AB - IgD levels in individuals infected with the human immunodeficiency viruses (HIV) were studied as a means of monitoring the character and timing of B cell activation in individuals with this infection. Significantly increased levels of IgD were characteristic of homosexual men who were HIV seropositive but asymptomatic or mildly symptomatic. The hyper IgD globulinaemia became progressively more pronounced in patients with increasingly severe infection and reached its most marked level in patients with AID Sreiated complex (ARC), In ARC patients, IgD levels were increased 8-8-fold above normal which was disproportionately greater than the 2 4-fold increase in IgG, the 1-8- fold increase in IgA and the 1-6-fold increase in IgM. IgD levels declined in AIDS patients (although remained elevated compared to controls). The data suggest that an unusual type of B cell activation is responsible for the unique pattern of hypergammaglobulinaemia seen in this disease and that the B cell activation occurs early in the pathogenesis of HIV infection, often before development of symptoms, and continues throughout the course of infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM
KW - B cells
KW - HIV (Viruses)
KW - AIDS (Disease)
KW - HYPERGAMMAGLOBULINEMIA
KW - LYMPHOCYTES
KW - AIDS
KW - HIV
KW - IgD
KW - polyclonal B cell activation
N1 - Accession Number: 16166910; Mizuma, H. 1,2 Zolla-Pazner, Susan 1,2 Litwin, S. 3 Wafaa El-Sadr 4,5 Sharpe, Sandra 2 Zehr, B. 3 Weiss, S. 6 Saxinger, W.C. 6 Marmor, M- 7; Affiliation: 1: Laboratory, New York Veterans Administration Medical Center, New York, NY. 2: Department of Pathology, New York University Medical Center, New York, NY. 3: Guthrie Research Institute, Sayre, PA. 4: Medical Services, New York Veterans Administration Medical Center, New York, NY. 5: Department of Medicine, New York University Medical Center, New York, NY. 6: National Cancer Institute, Bethesda, MD, USA. 7: Department of Environmental Medicine, New York University Medical Center, New York, NY.; Source Info: Apr1987, Vol. 68 Issue 1, p5; Subject Term: SERUM; Subject Term: B cells; Subject Term: HIV (Viruses); Subject Term: AIDS (Disease); Subject Term: HYPERGAMMAGLOBULINEMIA; Subject Term: LYMPHOCYTES; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: HIV; Author-Supplied Keyword: IgD; Author-Supplied Keyword: polyclonal B cell activation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jonsson, Lisbeth M. V.
AU - Murray, Gary J.
AU - Sorrell, Susan H.
AU - Strijland, Anneke
AU - Aerts, Johannes F. G. M.
AU - Ginns, Edward I.
AU - Barranger, John A.
AU - Tager, Joseph M.
AU - Schram, André W.
T1 - Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/04//4/1/87
VL - 164
IS - 1
M3 - Article
SP - 171
EP - 179
PB - Wiley-Blackwell
SN - 00142956
AB - The biosynthesis and maturation of glucocerebrosidase were studied in fibroblasts from patients with the neurological and non-neurological forms of Gaucher disease and in control cells. In control fibroblasts the precursor of glucocerebrosidase (62–63 kDa), observed after a short pulse with [35S]methionine, was converted during the chase period to a 66-kDa intermediate form and, finally, to the 59-kDa mature protein. In fibroblasts from patients with the non-neurological phenotype of Gaucher disease (type 1) the same biosynthetic forms were seen as in control fibroblasts. These biosynthetic forms correspond to the three-banded pattern seen in control and Gaucher type 1 fibroblast extracts analysed by the immunoblotting procedure, or after electrophoresis and fluorography of extracts of such fibroblasts cultured for 5 days with [14C]leucine. The 59-kDa protein seen in type 1 fibroblasts was unstable and disappeared after a prolonged chase; this disappearance was not observed when the cells were grown in the presence of leupeptin. In fibroblasts from patients with the neurological forms of Gaucher disease (types 2 and 3) the 62.5-kDa precursor of glucocerebrosidase was present in near-normal amounts after a short pulse, but the 59-kDa form was not detected even when cells were cultured with leupeptin. These results are in accordance with the absence of the 59-kDa band in immunoblots of types 2 and 3 fibroblast extracts. Culturing of type 1, type 2 and type 3 Gaucher fibroblasts in the presence of leupeptin led to an increase in the activity of glucocerebrosidase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSYNTHESIS
KW - ORGANIC synthesis (Chemistry)
KW - GAUCHER'S disease
KW - SPHINGOLIPIDOSES
KW - FIBROBLASTS
KW - CONNECTIVE tissue cells
N1 - Accession Number: 13669616; Jonsson, Lisbeth M. V. 1,2 Murray, Gary J. 2 Sorrell, Susan H. 2 Strijland, Anneke 1 Aerts, Johannes F. G. M. 1 Ginns, Edward I. 2 Barranger, John A. 2 Tager, Joseph M. 1 Schram, André W. 1; Affiliation: 1: Laboratory of Biochemistry, University of Amsterdam 2: Molecular and Medical Genetics Section, Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Source Info: 4/1/87, Vol. 164 Issue 1, p171; Subject Term: BIOSYNTHESIS; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: GAUCHER'S disease; Subject Term: SPHINGOLIPIDOSES; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hattori, Y.
AU - Siraganian, R. P.
T1 - Rapid phosphorylation of a 92,000 MW protein on activation of rat basophilic leukaemia cells for histamine release.
JO - Immunology
JF - Immunology
Y1 - 1987/04//
VL - 60
IS - 4
M3 - Article
SP - 573
EP - 578
PB - Wiley-Blackwell
SN - 00192805
AB - Many cellular functions are modulated by phosphorylation of proteins. The IgE- or ionophore-mediated activation of rat basophilic leukaemia cells (RBL-2H3) was accompanied by the prominent phosphorylation of a 92,000 molecular weight (MW) cellular component. The degree of phosphorylation of this component correlated with the extent of histamine release from the cells. This phosphorylation was rapid, reaching a maximum 2–5 min following the addition of the ionophore or antigen, and decreasing to background by 30 min. In contrast, histamine release is a much slower process. Although the phosphorylation required the presence of Ca2+ in the medium, it was not inhibited by La3+, which blocks the stimulated entry of Ca2+. Therefore, the stimulation of a Ca2+-dependent kinase is an early event in the activation of the rat basophilic leukaemia cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEUKEMIA
KW - CHEMICAL reactions
KW - PHOSPHORYLASES
KW - PHOSPHORYLATION
KW - ANTIGENS
KW - IMMUNOGLOBULINS
N1 - Accession Number: 14016513; Hattori, Y. 1 Siraganian, R. P. 1; Affiliation: 1: Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 60 Issue 4, p573; Subject Term: LEUKEMIA; Subject Term: CHEMICAL reactions; Subject Term: PHOSPHORYLASES; Subject Term: PHOSPHORYLATION; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yancey, Kim B.
AU - Bielory, Leonard
AU - Wright, Ralph
AU - Young, Neal
AU - Frank, Michael M.
AU - Lawley, Thomas J.
T1 - Patients With Bone Marrow Failure Demonstrate Decreased Cutaneous Reactivity to Human C5a.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/04//
VL - 88
IS - 4
M3 - Article
SP - 388
EP - 392
SN - 0022202X
AB - In vivo studies have shown that human C5a, a potent complement-derived anaphylatoxin and chemoattractant, produces immediate inflammatory reactions following intradermal injection in human skin. At concentrations within its potential physiologic range, intradermal injection of C5a elicits immediate wheal and flare reactions, increased vascular permeability, mast cell degranulation, and neutrophil-rich infiltrates. To assess the relative contribution of interacting cellular elements to C5a-induced inflammation in normal human skin, purified human C5a was tested intradermally in 8 patients with bone marrow failure (BMF). Reactions to C5a in patients with BMF were compared with responses at identical test sites in healthy volunteers and other patients with cutaneous disorders. Patients with BMF demonstrated significantly less wheal and flare reactivity following intradermal injection of C5a than controls (p < 0.05 and < 0.02, respectively). In these studies, patients with the greatest cytopenia generally showed the least cutaneous reactivity to human C5a. Biopsies of C5a test sites in patients with BMF revealed an absence of leukocytes in marked contrast to neutrophil-rich infiltrates observed at test sites in healthy volunteers. Avidin-fluorescein and/or Giemsa staining of skin biopsies revealed no difference between the number of dermal mast cells in patients with BMF and samples of normal human skin. In addition, skin test studies with histamine (2 μg) and morphine (5 μg) performed to assess cutaneous vascular and mast cell responsiveness in patients with BMF, normal volunteers, and controls with rhinitis revealed no significant differences in cutaneous reactivity to these pharmacologic agents. These in vivo studies demonstrate that patients with BMF specifically exhibit decreased cutaneous reactivity to human C5a and suggest that neutrophils make an important and an immediate contribution to inflammatory responses elicited by this anaphylatoxin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE marrow
KW - IMMUNE system
KW - INFLAMMATION
KW - MAST cells
KW - NEUTROPHILS
KW - PATIENTS
N1 - Accession Number: 12469445; Yancey, Kim B. 1 Bielory, Leonard 2 Wright, Ralph 3 Young, Neal 2 Frank, Michael M. 4 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National institutes of Health 2: Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institute of Health 3: Nursing Department, Clinical Center, National Institute of Health 4: Laboratory of Clinical Investigation, National Institute of Allergy and Infections Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 88 Issue 4, p388; Subject Term: BONE marrow; Subject Term: IMMUNE system; Subject Term: INFLAMMATION; Subject Term: MAST cells; Subject Term: NEUTROPHILS; Subject Term: PATIENTS; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12469445
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krey, Anne K.
AU - Moshell, Allan N.
AU - Dayton, Delbert H.
AU - Sawyer, Roger H.
AU - Holbrook, Karen A.
T1 - Morphogenesis and Malformations of the Skin NICHD/NIADDK Research Workshop.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/04//
VL - 88
IS - 4
M3 - Article
SP - 464
EP - 473
SN - 0022202X
AB - Developmentally caused skin malformations constitute a spectrum of birth defects, some of which can be recognized prenatally by morphologic or biochemical means. The number of prenatally diagnosable skin diseases could be greatly expanded with an increased understanding of the molecular and cellular bases of skin development and the mechanisms that result in the generation of skin defects. The National Institute of Child Health and Human Development and the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, therefore, sponsored a workshop that recommended basic biologic studies combined with clinical investigations of normal and abnormal cutaneous development set forth in this article. Investigations resulting from these research recommendations are intended to contribute to the knowledge that should aid in the prevention of developmentally caused skin deformities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - MORPHOGENESIS
KW - BIOCHEMISTRY
KW - SKIN diseases
KW - KIDNEYS
KW - DIABETES
N1 - Accession Number: 12469911; Krey, Anne K. 1 Moshell, Allan N. 1 Dayton, Delbert H. 1 Sawyer, Roger H. 1 Holbrook, Karen A. 1; Affiliation: 1: National Institute of Child Health and Human Development/National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, U.S.A.; Source Info: Apr87, Vol. 88 Issue 4, p464; Subject Term: SKIN; Subject Term: MORPHOGENESIS; Subject Term: BIOCHEMISTRY; Subject Term: SKIN diseases; Subject Term: KIDNEYS; Subject Term: DIABETES; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1523-1747.ep12469911
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06447-014
AN - 2006-06447-014
AU - Crawley, Jacqueline N.
T1 - Drugs for Undergraduates.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/04//
VL - 32
IS - 4
SP - 329
EP - 330
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06447-014. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Crawley, Jacqueline N.; Unit on Behavioral Neuropharmacology, Clinical Neurosdence Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Benzodiazepines; Psychopharmacology. Minor Descriptor: Caffeine; Drugs; Neuroanatomy; Neurophysiology; Nicotine; Opiates. Classification: Psychopharmacology (2580). Population: Human (10). Reviewed Item: McKim, William A. Drugs and Behavior: An Introduction to Behavioral Pharmacology=Englewood Cliffs, NJ: Prentice-Hall, 1986. 288 pp. $20.95 paperback; 1986. Page Count: 2. Issue Publication Date: Apr, 1987.
AB - Reviews the book, Drugs and Behavior: An Introduction to Behavioral Pharmacology by William A. McKim (1986). This book incorporates some, but not all, of the exciting advances in psychopharmacology, in a simple, appealing format. The first half of the book introduces basic principles of behavioral pharmacology. The chapter summarizing neuroanatomy, neurophysiology, and neuropharmacology is too short, however, requiring a companion book or an additional neuroscience course. The second half of the book contains intensive chapters on individual drugs of particular interest: alcohol, barbiturates, benzodiazepines, tobacco, caffeine, opiates, cannabis, hallucinogens, stimulants, and antidepressants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drugs
KW - behavioral pharmacology
KW - neuroanatomy
KW - neurophysiology
KW - neuropharmacology
KW - benzodiazepines
KW - tobacco
KW - caffeine
KW - opiates
KW - 1987
KW - Benzodiazepines
KW - Psychopharmacology
KW - Caffeine
KW - Drugs
KW - Neuroanatomy
KW - Neurophysiology
KW - Nicotine
KW - Opiates
KW - 1987
U2 - McKim, William A. (1986); Drugs and Behavior: An Introduction to Behavioral Pharmacology; Englewood Cliffs, NJ: Prentice-Hall, 1986. 288 pp. $20.95 paperback
DO - 10.1037/026981
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Rhoads, George G.
T1 - Reliability of diet measures as chronic disease risk factors.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/05//
VL - 45
IS - 5
M3 - Article
SP - 1073
EP - 1079
SN - 00029165
AB - The article focuses on the relation of diet to the development of chronic disease, with special reference to coronary heart disease. In experimental studies the effect of dietary saturated fatty acid intake on serum low density lipoprotein (LDL) level has been amply confirmed. It mentions about methods used to study the impact of diet on health.
KW - Diet
KW - Nutrition -- Requirements
KW - Food -- Composition
KW - Nutrition -- Evaluation
KW - Coronary heart disease
N1 - Accession Number: 91253854; Rhoads, George G. 1; Affiliations: 1: Epidemiology and Biometry Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Issue Info: May1987, Vol. 45 Issue 5, p1073; Subject Term: Diet; Subject Term: Nutrition -- Requirements; Subject Term: Food -- Composition; Subject Term: Nutrition -- Evaluation; Subject Term: Coronary heart disease; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Richters, John E.
T1 - Infant-Mother Attachment: The Origins and Developmental Significance of Individual Differences in Strange Situation Behavior (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1987/05//May/Jun87
VL - 75
IS - 3
M3 - Book Review
SP - 318
EP - 318
SN - 00030996
AB - Reviews the book `Infant-Mother Attachment: The Origins and Developmental Significance of Individual Differences in Strange Situation Behavior,' by Michael E. Lamb, Ross A. Thompson, William Gardner and Eric L. Charnov.
KW - Lamb, Michael E.
KW - Thompson, Ross A.
KW - Gardner, William
KW - Charnov, Eric L.
KW - Infant-Mother Attachment (Book)
N1 - Accession Number: 11231167; Richters, John E. 1; Affiliations: 1: National Institute of Mental Health; Issue Info: May/Jun87, Vol. 75 Issue 3, p318; Reviews & Products: Infant-Mother Attachment (Book); People: Lamb, Michael E.; People: Thompson, Ross A.; People: Gardner, William; People: Charnov, Eric L.; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boutin, B.
AU - Wagner, D. K.
AU - Nelson, D. L.
T1 - Analysis of CD3 antigen expression in patients with ataxia-telangiectasia.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/05//
VL - 68
IS - 2
M3 - Article
SP - 320
EP - 330
PB - Wiley-Blackwell
SN - 00099104
AB - The expression of CD3 molecules by the lymphocytes of five patients with ataxia-telangiectasia was examined using the murine monoclonal antibody OKT3. By immunofluorescent staining, fewer of the patients' peripheral blood mononuclear cells and purified T cells expressed CD3 compared with normals. The proliferative response of the patients' cells to 0KT3 was also less than normal. However, the mononuclear cells from all five patients produced lL-2 after OKT3 stimulation: in four patients IL-2 was normal, while one patient produced greater than normal levels. While the expression of cellular IL- 2 receptors and the release of these receptors into culture supernatants was generally less in ataxia-telangiectasia patients. The levels of receptor expression were not significantly less than normal. As analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis. the CD 3 molecules from ataxia-telangiectasia patients' lymphocytes were no different from those of normal individuals. These results suggest that patients with ataxiatclangiectasia have structurally normal CD3 molecules which may be used to activate cells normally for some but not all T cell functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - LYMPHOCYTES
KW - TELANGIECTASIA
KW - T cells
KW - GEL electrophoresis
KW - MOLECULAR cloning
KW - LEUCOCYTES
KW - ataxia-telangiectasia
KW - CD3
KW - interleukin 2.
N1 - Accession Number: 16171620; Boutin, B. 1 Wagner, D. K. 1 Nelson, D. L. 1; Affiliation: 1: Imnnmophysiology Section. Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA.; Source Info: May1987, Vol. 68 Issue 2, p320; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: TELANGIECTASIA; Subject Term: T cells; Subject Term: GEL electrophoresis; Subject Term: MOLECULAR cloning; Subject Term: LEUCOCYTES; Author-Supplied Keyword: ataxia-telangiectasia; Author-Supplied Keyword: CD3; Author-Supplied Keyword: interleukin 2.; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malbran, A.
AU - Frank, M. M.
AU - Fries, L. F.
T1 - Interactions of monomeric IgG bearing covalently bound C3b with polymorphonuclear leucocytes.
JO - Immunology
JF - Immunology
Y1 - 1987/05//
VL - 61
IS - 1
M3 - Article
SP - 15
EP - 20
PB - Wiley-Blackwell
SN - 00192805
AB - The interactions of monomeric IgG, monomeric C3b, dimeric C3b, and C3b covalently bound to IgG (C3b-IgG) with neutrophils were examined. C3b-IgG heterodimers exhibited an increased affinity of binding to neutrophils, relative to C3b, both at half normal ionic strength (five-fold enhancement) and at normal ionic strength (six-fold enhancement). Binding of monomeric IgG to neutrophils was barely detectable and did not permit direct measurements of affinity in our assay conditions. The increased affinity of C3b-IgG for neutropbils was the result of divalent interactions with CR1, the C3b receptor, and the Fcγ receptor of the cells, as could be demonstrated by competition studies using unlabelled IgG in the medium or monoclonal antibodies against the neutrophil Fcγ receptor. This double receptor-ligand interaction allowed C3b-IgG to bind to the ceils not only at normal ionic strength, but also in the presence of a 315-fold excess of IgG (near plasma concentration)- conditions that would preclude the binding of C3b or IgG alone. Furthermore, this interaction leads to the internalization of the C3b-IgG complex by the cells. C3b-IgG is internalized with kinetics similar to those found using dimeric C3b, with resting cells demonstrating a slow initial phase, which is accelerated by phorbol ester activation in both cases. Uptake of the homodimeric C3b was greater at 15 min than that of heterodimeric C3b-IgG, but both were significantly greater than that of monomer C3b, which showed no net internalization. The physiological implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUTROPHILS
KW - MEDICAL sciences
KW - CELLULAR recognition
KW - MONOCLONAL antibodies
N1 - Accession Number: 13504405; Malbran, A. 1 Frank, M. M. 1 Fries, L. F. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: May87, Vol. 61 Issue 1, p15; Subject Term: NEUTROPHILS; Subject Term: MEDICAL sciences; Subject Term: CELLULAR recognition; Subject Term: MONOCLONAL antibodies; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06448-016
AN - 2006-06448-016
AU - Jones, Barbara Pendleton
T1 - Advise and Dissent.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/05//
VL - 32
IS - 5
SP - 431
EP - 432
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06448-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Jones, Barbara Pendleton; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Correction Date: 20151207. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Neuropsychological Assessment; Neuropsychology. Minor Descriptor: Test Battery. Classification: Neuropsychological Assessment (2225). Population: Human (10). Reviewed Item: Incagnoli, Theresa (Ed); Goldstein, Gerald (Ed); Golden, Charles J. (Ed). Clinical Application of Neuropsychological Test Batteries=New York: Plenum Press, 1986. 408 pp. $42.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: May, 1987.
AB - Reviews the book, Clinical Application of Neuropsychological Test Batteries by Theresa Incagnoli, Gerald Goldstein, and Charles J. Golden (Eds.) (1986). This volume grew out of a Veterans Administration (VA) conference that was originally intended as a forum for debating which of the two most commonly used neuropsychological test batteries, the venerable Halstead-Reitan Neuropsychological Test Battery (HRB) or the newer Luria-Nebraska Neuropsychological Test Battery (LNNB), would prevail within the VA system. To the extent that the book speaks to both sides of controversy regarding debate within current clinical neuropsychology, that is, the debate over the relative merits of the fixed-battery approach versus the individualized test selection approach., it represents a refreshing change from recent one-sided approaches disguised as comprehensive treatments. This is a volume that will be of more interest to relative newcomers to neuropsychology than to experienced practitioners in the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuropsychological test batteries
KW - clinical neuropsychology
KW - 1987
KW - Neuropsychological Assessment
KW - Neuropsychology
KW - Test Battery
KW - 1987
U2 - Incagnoli, Theresa (Ed); Goldstein, Gerald (Ed); Golden, Charles J. (Ed). (1986); Clinical Application of Neuropsychological Test Batteries; New York: Plenum Press, 1986. 408 pp. $42.50; 0-306-42045-7.
DO - 10.1037/027121
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06448-043
AN - 2006-06448-043
AU - Hadley, Suzanne W.
T1 - What's Good About Psychopathology?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/05//
VL - 32
IS - 5
SP - 462
EP - 462
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06448-043. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; Extramural Policy Branch, Division of Extramural Activities, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychopathology; Society. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Pallone, Nathaniel J. On the Social Utility of Psychopathology: A Deviant Majority and its Keepers?=New Brunswick, NJ: Transaction Books, 1986. 79 pp. $24.95; 1986. Page Count: 1. Issue Publication Date: May, 1987.
AB - Reviews the book, On the Social Utility of Psychopathology: A Deviant Majority and its Keepers? by Nathaniel J. Pallone (see record [rid]1986-97533-000[/rid]). This is a remarkable little book. The author's theses are very clear. He seeks to establish that psychopathology is useful to society, indeed, that psychopathology is essential for the maintenance of society. Furthermore, he suggests that it is this vital functional relationship between society and psychopathology that is responsible for the continued existence of psychopathology, and for the endlessly proliferating assemblage of institutions and professions that ostensibly are devoted to healing the mentally ill. The book would make an excellent resource for a graduate seminar on the ethics and philosophy of mental health care Despite its outlandish price, I recommend it with some enthusiasm to interested readers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathology
KW - society
KW - mentally ill
KW - 1987
KW - Psychopathology
KW - Society
KW - 1987
U2 - Pallone, Nathaniel J. (1986); On the Social Utility of Psychopathology: A Deviant Majority and its Keepers?; New Brunswick, NJ: Transaction Books, 1986. 79 pp. $24.95
DO - 10.1037/027148
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06448-047
AN - 2006-06448-047
AU - Rapoport, Judith L.
T1 - What Happens to Hyperactive Children?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/05//
VL - 32
IS - 5
SP - 465
EP - 466
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06448-047. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Rapoport, Judith L.; Child Psychiatry Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Human Development; Hyperkinesis. Minor Descriptor: Drug Therapy. Classification: Developmental Disorders & Autism (3250). Population: Human (10). Reviewed Item: Weiss, Gabrielle; Hechtman, Lily Trokenberg. Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations=New York: Guilford Press, 1986. 367 pp. $32.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: May, 1987.
AB - Reviews the book, Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations by Gabrielle Weiss and Lily Trokenberg Hechtman (1986). In this book authors convey their formidable experience in studying and following a group of more than 100 hyperactive children from grade school years to young adulthood. This is a lovely book. But, to do it justice, one must be clear about what the authors intended to do, which is to convey in detailed and leisurely style an immense body of data accumulated over 15 years. This is the first major prospective, controlled follow-up study of hyperactive children. The authors have a lucid style, and their open, honest presentation of data is exemplary. The most interesting findings, and unique to this study, are those resulting from the careful examination of the long-term effects of stimulant drug treatment on ultimate functioning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hyperactive children
KW - stimulant drug treatment
KW - longterm develoment
KW - 1987
KW - Human Development
KW - Hyperkinesis
KW - Drug Therapy
KW - 1987
U2 - Weiss, Gabrielle; Hechtman, Lily Trokenberg. (1986); Hyperactive Children Grown Up: Empirical Findings and Theoretical Considerations; New York: Guilford Press, 1986. 367 pp. $32.50; 0-89862-661-7.
DO - 10.1037/027152
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gierschik, Peter
AU - Sidiropoulos, Dimitrios
AU - Jakobs, Karl H.
AU - Spiegel, Allen
T1 - Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/05/15/
VL - 165
IS - 1
M3 - Article
SP - 185
EP - 194
PB - Wiley-Blackwell
SN - 00142956
AB - Bovine peripheral neutrophils contain high levels of a 40-kDa pertussis toxin substrate, which was found highly enriched in a light membrane fraction upon subcellular fractionation of neutrophil homogenates. The 40kDa pertussis toxin substrate, referred to as &alphan, was purified to near homogeneity from this fraction by sequential ion-exchange, gel-filtration and hydrophobic chromatography. Purified αn was shown to interact with βγ subunits, undergo ADP-ribosylation by pertussis toxin, and bind guanine nucleotides with high affinity. The mobility of purified αn on SDS/polyacrylamide gels was intermediate between those of the α subunits of Gi and Go, purified from bovine brain, and slightly lower than the mobility of the α subunit of transducin (Gt). Several polyclonal antisera against the α subunits of bovine Gtt and Go did not react with αn on immunoblots. CW 6, a polyclonal antiserum reactive against the bovine αi, reacted only minimally with αn. These results suggest that the major pertussis toxin substrate of bovine neutrophils, designated Gn, is structurally different from previously identified pertussis toxin substrates and may represent a novel gnanine-nucleotide-binding protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIAL toxins
KW - NEUTROPHILS
KW - GRANULOCYTES
KW - COLLOIDS
KW - CHROMATOGRAPHIC analysis
KW - CELLULAR signal transduction
N1 - Accession Number: 13813336; Gierschik, Peter 1 Sidiropoulos, Dimitrios 1 Jakobs, Karl H. 1 Spiegel, Allen 2; Affiliation: 1: Pharmakologisches Institut, Universität Heidelberg 2: Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: 5/15/87, Vol. 165 Issue 1, p185; Subject Term: BACTERIAL toxins; Subject Term: NEUTROPHILS; Subject Term: GRANULOCYTES; Subject Term: COLLOIDS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CELLULAR signal transduction; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 4 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TENNANT, RAYMOND W.
AU - MARGOLIN, BARRY H.
AU - SHELBY, MICHAEL D.
AU - ZEIGER, ERROL
AU - HASEMAN, JOSEPH K.
AU - SPALDING, JUDSON
AU - CASPARY, WILLIAM
AU - RESNICK, MICHAEL
AU - STASIEWICZ, STANLEY
AU - ANDERSON, BETH
AU - MINOR, ROBERT
T1 - Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetc Toxicity Assays.
JO - Science
JF - Science
Y1 - 1987/05/22/
VL - 236
IS - 4804
M3 - Article
SP - 933
EP - 941
SN - 00368075
AB - Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents. These assays were mutagenesis in Salmonella and mouse lymphoma cells and chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells. Seventy-three chemicals recently tested in 2-year carcinogenicity studies conducted by the National Cancer Institute and the National Toxicology Program were used in this evaluation. Test results from the four in vitro assays did not show significant differences in individual cobcordance with the rodent carcinogenicity results; the concordance of each assay was approximately 60 percent. Within the limits of this study there was no evidence of complementarity among the four assays, and no battery of tests constructed from these assays improved substantially on the overall performance of the Salmonella assay. The in vitro assays which represented a range of three cell types and four end points did show substantial agreement among themselves, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro assays. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692489; TENNANT, RAYMOND W. 1 MARGOLIN, BARRY H. 2 SHELBY, MICHAEL D. 1 ZEIGER, ERROL 1 HASEMAN, JOSEPH K. 2 SPALDING, JUDSON 1 CASPARY, WILLIAM 1 RESNICK, MICHAEL 1 STASIEWICZ, STANLEY 1 ANDERSON, BETH 1 MINOR, ROBERT 3; Affiliation: 1: Cellular and Genetic Toxicology Branch, Toxicology Research and Testing Divisioo, National Institute of Environmental Health Sciences, Research Tnangle Park, NC 27709 2: Statistics and Biomathematics Branch, Biometry and Risk Assessment Division, National Institute of Environmental Health Sciences, Research Trianglc Park, NC 27709 3: Information Systems and Networks Corporation, Research Triangle Park, NC 27709; Source Info: 5/22/1987, Vol. 236 Issue 4804, p933; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SNAPPER, CLIFFORD M.
AU - PAUL, WILLIAM E.
T1 - Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production.
JO - Science
JF - Science
Y1 - 1987/05/22/
VL - 236
IS - 4804
M3 - Article
SP - 944
EP - 947
SN - 00368075
AB - Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF- 1 has powerful effects in promoting switching to the expression of IgGl and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotypc responses. The effects ofIFN-γ and BSF-1 on isotype expression are independent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692491; SNAPPER, CLIFFORD M. 1 PAUL, WILLIAM E. 1; Affiliation: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/22/1987, Vol. 236 Issue 4804, p944; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, D. Yvonne
AU - Judd, Joseph T.
AU - Taylor, Philip R.
AU - Campbell, William S.
AU - Nair, Padmanabhan P.
T1 - Influence of caloric contribution and saturation of dietary fat on plasma lipids in premenopausal women.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/06//
VL - 45
IS - 6
M3 - Article
SP - 1451
EP - 1456
SN - 00029165
AB - Total cholesterol, HDL cholesterol, and triglycerides were measured in 31 pre-menopausal women randomized into one of two diet groups: one diet with a P:S ratio of 1.0 and one diet with a P:S ratio of 0.3. Both groups were fed a high-fat diet (40% of energy from fat) for four menstrual cycles per subject followed by a similar interval on a low-fat diet (20% of energy from fat). Changing from the high-fat to the low-fat diet resulted in a nonsignificant mean decrease of 7% in total cholesterol. HDL-cholesterol response to the low-fat regimen was influenced by the P:S ratio. Women in the high P:S group showed no change; mean HDL cholesterol in women in the low P:S group decreased 12%. Plasma triglycerides increased in both groups on the low-fat diet although the increase was greatest in the low P:S group. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Caloric content
KW - Dietaries
KW - Blood plasma
KW - Perimenopause
KW - Lipids
KW - Cholesterol
KW - P:S ratio
KW - polyunsaturated fat
KW - triglycerides
N1 - Accession Number: 91550197; Jones, D. Yvonne 1; Judd, Joseph T. 2; Taylor, Philip R. 1; Campbell, William S. 1; Nair, Padmanabhan P. 2; Affiliations: 1: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, NIH, DHHS; 2: Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA; Issue Info: Jun1987, Vol. 45 Issue 6, p1451; Subject Term: Food -- Caloric content; Subject Term: Dietaries; Subject Term: Blood plasma; Subject Term: Perimenopause; Subject Term: Lipids; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: P:S ratio; Author-Supplied Keyword: polyunsaturated fat; Author-Supplied Keyword: triglycerides; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bieri, John G.
T1 - Fat-Soluble Vitamins: Their Biochemistry and Applications.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/06//
VL - 45
IS - 6
M3 - Book Review
SP - 1549
EP - 1550
SN - 00029165
KW - Vitamin D
KW - Nonfiction
KW - Diplock, Anthony T.
KW - Fat-Soluble Vitamins: Their Biochemistry & Applications (Book)
N1 - Accession Number: 91550213; Bieri, John G. 1; Affiliations: 1: National Institutes of Health Bethesda, MD 20892; Issue Info: Jun1987, Vol. 45 Issue 6, p1549; Subject Term: Vitamin D; Subject Term: Nonfiction; Reviews & Products: Fat-Soluble Vitamins: Their Biochemistry & Applications (Book); People: Diplock, Anthony T.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parker, Douglas A.
AU - Parker, Elizabeth S.
AU - Hareord, Thomas C.
AU - Farmer, Gail C.
T1 - Alcohol Use and Depression Symptoms among Employed Men and Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/06//
VL - 77
IS - 6
M3 - Article
SP - 704
EP - 707
PB - American Public Health Association
SN - 00900036
AB - Abstract: A representative sample of 1,367 employed men and women in Detroit responded lo questions about drinking practices and symptoms of depression. After controlling for age, education. family income, marital status, medication use, fathers' drinking, and other variables, increased quantity of alcohol consumed per drinking occasion was associated with increased depression symptoms in the sober state among men anti women. Depression symptoms may be one of a group of not fully identified drug after-effect disorders involving psychological functioning. (Am J Public Health 1987; 77:704-707). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRINKING of alcoholic beverages
KW - MEDICAL care surveys
KW - INDUSTRIAL hygiene
KW - MENTAL depression
KW - DEPRESSION in women
KW - DEPRESSION in men
KW - ALCOHOLISM
KW - DRINKING behavior
KW - MARITAL status
KW - ALCOHOLIC beverages
N1 - Accession Number: 4951034; Parker, Douglas A. 1 Parker, Elizabeth S. 2 Hareord, Thomas C. 3 Farmer, Gail C. 4; Affiliation: 1: Professor of Sociology. California State University, 12.50 Bellflower Blvd., Long Reach, CA 90840. 2: Research Psychologist in the Neuropsychiatric Institute at the University of California, Los Angeles. 3: Acting Director of the Bioinetry and Epidemiology Division at the National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 4: Assistant Professor of Health Science and Sociology at the California State University, Long Bea; Source Info: Jun87, Vol. 77 Issue 6, p704; Subject Term: DRINKING of alcoholic beverages; Subject Term: MEDICAL care surveys; Subject Term: INDUSTRIAL hygiene; Subject Term: MENTAL depression; Subject Term: DEPRESSION in women; Subject Term: DEPRESSION in men; Subject Term: ALCOHOLISM; Subject Term: DRINKING behavior; Subject Term: MARITAL status; Subject Term: ALCOHOLIC beverages; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 312140 Distilleries; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shern, Roald J.
AU - Mirth, Dale B.
AU - Emilson, Claes- Göran
AU - Adderly, Donna D.
AU - Bowen, William H.
T1 - Evaluation of an intraoral controlled release delivery system for fluoride in primates.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1987/06//
VL - 15
IS - 3
M3 - Article
SP - 113
EP - 116
SN - 03015661
AB - An intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. This fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (Macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. No changes were observed in the plaque and gingival scores or the populations of various species of plaque bacteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMATES
KW - FLUORIDES
KW - SALIVA
KW - INCISORS
KW - MICROBIOLOGY -- Technique
KW - MONKEYS
KW - dental plaque bacteria
KW - fluoride
KW - intraoral device
KW - primate
N1 - Accession Number: 12014045; Shern, Roald J. 1 Mirth, Dale B. 1 Emilson, Claes- Göran 2 Adderly, Donna D. 1 Bowen, William H. 3; Affiliation: 1: Epidemiology and Oral Disease Prevention Program National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA. 2: Department of Cariology. Faculty of Odontology, University of Göteborg, Gothenburg, Sweden. 3: Department of Dental Research, University of Rochester, Rochester, NY, USA.; Source Info: Jun1987, Vol. 15 Issue 3, p113; Subject Term: PRIMATES; Subject Term: FLUORIDES; Subject Term: SALIVA; Subject Term: INCISORS; Subject Term: MICROBIOLOGY -- Technique; Subject Term: MONKEYS; Author-Supplied Keyword: dental plaque bacteria; Author-Supplied Keyword: fluoride; Author-Supplied Keyword: intraoral device; Author-Supplied Keyword: primate; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1600-0528.ep12014045
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsuji, Shoji
AU - Martin, Brian M.
AU - Kaslow, David C.
AU - Migeon, Barbara R.
AU - Choudary, Prabhakara V.
AU - Stubbleflied, Barbara K.
AU - Mayor, June A.
AU - Murray, Gary J.
AU - Barranger, John A.
AU - Ginns, Edward I.
T1 - Signal sequence and DNA-mediated expression of human lysosomal α-galactosidase A.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/06//6/1/87
VL - 165
IS - 2
M3 - Article
SP - 275
EP - 280
PB - Wiley-Blackwell
SN - 00142956
AB - Twelve complementary DNA clones for human lysosomal α-galactosidase A were isolated from an OkayamaBerg library constructed from SV40-transformed human fibroblasts. The identity of these clones was confirmed by complete colinearity of the nucleotide-deduced amino acid sequence with that determined by direct chemical sequencing of human placental α-galactosidase A. Hybridization of the α-galactosidase A cDNA to genomic DNA from individuals with varying numbers of X chromosomes as well as from interspecies somatic-cell hybrids showed only a single locus in the genome at Xq 13.1-Xq 22. One eDNA clone (pcD-AG210) contained the complete coding sequence for both the signal peptide and mature α-galactosidase A. The signal peptide of 31 amino acids contains the expected hydrophobic domains consisting of Leu-Gly-Cys-Ala-Leu-Ala-Leu and PheLeu-Ala-Leu-Val and has Ala at the signal peptidase cleavage site. Twelve out of fifteen G residues flanking the 5' end of the cDNA in pcD-AG210 were removed and the truncated fragment was ligated into the original vector. This construct, pcD-AG502, encoded enzymatically active human α-galactosidase A in monkey COS cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYSOSOMES
KW - GALACTOSE
KW - DNA
KW - AMINO acids
KW - GENOMES
KW - GENETICS
N1 - Accession Number: 13726966; Tsuji, Shoji 1 Martin, Brian M. 1 Kaslow, David C. 2 Migeon, Barbara R. 2 Choudary, Prabhakara V. 3 Stubbleflied, Barbara K. 1 Mayor, June A. 1 Murray, Gary J. 4 Barranger, John A. 5 Ginns, Edward I. 1; Affiliation: 1: Molecular Neurogenetics Unit, Clinical Neuroscience Branch, National Institute of Mental Health, Alcohol, Drug Abuse and Mental Health Administration, Bethesda, Maryland 2: Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 3: Centers for Biotechnology and for Advanced Research in Molecular Genetics, Jawaharlal Nehru University, New Delhi 4: Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders, and Stroke, National Institutes of Health, Bethesda, Maryland 5: Division of Medical Genetics, Children's Hospital of Los Angeles, California; Source Info: 6/1/87, Vol. 165 Issue 2, p275; Subject Term: LYSOSOMES; Subject Term: GALACTOSE; Subject Term: DNA; Subject Term: AMINO acids; Subject Term: GENOMES; Subject Term: GENETICS; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lakatta, Edward G.
T1 - Why cardiovascular function may decline with age.
JO - Geriatrics
JF - Geriatrics
Y1 - 1987/06//
VL - 42
IS - 6
M3 - Article
SP - 84
EP - 93
SN - 0016867X
N1 - Accession Number: 15865245; Lakatta, Edward G. 1,2,3; Source Information: Jun1987, Vol. 42 Issue 6, p84; Number of Pages: 8p; Illustrations: 1 Color Photograph, 1 Diagram, 10 Graphs; Document Type: Article; Full Text Word Count: 2680
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Dezubroski, Theodore M.
AU - Costa Jr., Paul T.
T1 - Coronary Prone Behavior: Components of the Type A Pattern and Hostility.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1987/06//
VL - 55
IS - 2
M3 - Article
SP - 211
EP - 235
PB - Wiley-Blackwell
SN - 00223506
AB - Traditional and nontraditional risk factors for coronary heart disease (CHD) are discussed with special attention devoted to the Type. A behavior pattern (TABP) Positive and negative epidemiological evidence bearing on the risk factor status of global TABP is reviewed Results of the review suggest that component scoring of the multidimensional global TABP in attempts to uncover "toxic" components, particularly Potential for Hostility, is a profitable research strategy. Similarly, evidence is presented that suggests merit in component scoring of hostility, also a multidimensional construct. To explicate more fully the nature of Potential for Hostility and its categories, correlations between the SI- derived ratings and ratings of established dimensions of individual differences based on the five-factor taxonomic model of personality from subsamples of the MRFIT and WCGS studies are presented. Total Potential for Hostility and especially the Style of interaction category show highly significant relations to Low Agreeableness or Antagonism High ratings of Potential for Hostility identify individuals who can be described as uncooperative, antagonistic, rude, disagreeable, unsympathetic, callous, and the like Implications of the evolving concept of coronary-prone behavior, as distinguished from TABP, are briefly considered [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART diseases -- Risk factors
KW - HEART diseases
KW - CORONARY heart disease
KW - TYPE A behavior
KW - HUMAN behavior
KW - INDIVIDUAL differences
KW - DIFFERENTIAL psychology
N1 - Accession Number: 8970718; Dezubroski, Theodore M. 1 Costa Jr., Paul T. 2; Affiliation: 1: Department of Psychology, University of Maryland, Baltimore County. 2: Gerontology Research Center, National Institute on Aging, National Institutes of Health.; Source Info: Jun87, Vol. 55 Issue 2, p211; Subject Term: HEART diseases -- Risk factors; Subject Term: HEART diseases; Subject Term: CORONARY heart disease; Subject Term: TYPE A behavior; Subject Term: HUMAN behavior; Subject Term: INDIVIDUAL differences; Subject Term: DIFFERENTIAL psychology; Number of Pages: 25p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970718
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Costa Jr., Paul T.
AU - McCrae, Robert R.
T1 - Neuroticism, Somatic Complaints, and Disease: Is the Bark Worse than the Bite?
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1987/06//
VL - 55
IS - 2
M3 - Article
SP - 299
EP - 316
PB - Wiley-Blackwell
SN - 00223506
AB - Perhaps because negative emotions are frequently expressed in physiological reactions, psychosomatic theories have often identified Neuroticism and its component traits (including anxiety, anger, and depression) as causal influences on the development of disease These views are apparently supported by correlations between physical symptom reports and measures of Neuroticism in males Data from 347 adult women in the Baltimore Longitudinal Study of Aging replicate this finding for total physical complaints and for most body systems However, analyses of mortality in the literature and in the present article show no influence of Neuroticism, suggesting that symptom re- porting may be biased by Neuroticism-related styles of perceiving and reporting physiological experiences Researchers in this area are urged to employ objective measures of medical status, and to be alert to possible biases of self-selection and selective perception in interpreting associations between Neuroticism and disease [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHOSOMATIC medicine -- Research
KW - STRESS (Psychology)
KW - WOMEN -- Health
KW - NEUROSES
KW - LONGITUDINAL method
KW - CORRELATION (Statistics)
N1 - Accession Number: 8970749; Costa Jr., Paul T. 1 McCrae, Robert R. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Jun87, Vol. 55 Issue 2, p299; Subject Term: PSYCHOSOMATIC medicine -- Research; Subject Term: STRESS (Psychology); Subject Term: WOMEN -- Health; Subject Term: NEUROSES; Subject Term: LONGITUDINAL method; Subject Term: CORRELATION (Statistics); Number of Pages: 18p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970749
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WALLIKER, DAVID
AU - QUAKYI, ISABELLA A.
AU - WELLEMS, THOMAS E.
AU - MCCUTCHAN, THOMAS F.
AU - SZARFMAN, ANA
AU - LONDON, WILLIAM T.
AU - CORCORAN, LYNN M.
AU - BURKOT, THOMAS R.
AU - CARTER, RICHARD
T1 - Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum.
JO - Science
JF - Science
Y1 - 1987/06/26/
VL - 236
IS - 4809
M3 - Article
SP - 1661
EP - 1666
SN - 00368075
AB - Malaria parasites are haploid for most of their life cycle, with zygote formation and meiosis occurring during the mosquito phase of development. The parasites can be analyzed genetically by transmiting mixtures of cloned parasites through mosquitoes to permit cross-fertilization of gametes to occur. A cross was made between two clones of Plasmodiumfakciparum differing in enzymes, drug sensitivity, antigens, and chromosome patterns. Parasites showing recombination between the parent clone markers were detected at a high frequency. Novel forms of certain chromosomes, detected by pulsed-field gradient gel electrophoresis, were produced readily, showing that extensive rearrangements occur in the parasite genome after cross-ferdlization. Since patients are frequently infected with mixtures ofgenetically distinct parasites, mosquito transmission is likely to provide the principal mechanisms for generating parasites with novel genotypes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436755; WALLIKER, DAVID 1 QUAKYI, ISABELLA A. 1 WELLEMS, THOMAS E. 1 MCCUTCHAN, THOMAS F. 1 SZARFMAN, ANA 2 LONDON, WILLIAM T. 3 CORCORAN, LYNN M. 4 BURKOT, THOMAS R. 5 CARTER, RICHARD 1,6; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Heafth, Bethesda, MD 20892 2: Naval Medical Research Institute and Uniformed Services Universitv of Health Sciences, Bethesda, MD 20814 3: National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4: Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia 5: Papua New Guinea Institute of Medical Research, Post Office Box 378, Madang, Papua New Guinea 6: Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 31N, Scotland.; Source Info: 6/26/1987, Vol. 236 Issue 4809, p1661; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campos, Florisbela A. C. S.
AU - Flores, Hemando
AU - Underwood, Barbara A.
T1 - Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR).
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/07//
VL - 46
IS - 1
M3 - Article
SP - 91
EP - 94
SN - 00029165
AB - The effect of an infective episode of chickenpox on the vitamin A status of preschool-aged children was evaluated by use of the relative dose response (RDR) test. Status was determined before and 30, 120, and 180 d after administration of a single oral high-dosage (200 000 IU) supplement of vitamin A. No differences in mean blood levels of retinol or percentage of children showing a positive RDR were apparent until after the infective episode that occurred ~90 d after dosing. At 180 d postsupplementation, 74% of children who had been infected tested positive by the RDR, indicative of an inadequate liver reserve of vitamin A, in contrast to only 10% who had not been infected. Paired RDR observations at 0 and 180 d postsupplementation confirmed that the infective episode caused an accelerated depletion of liver reserves of vitamin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Infection
KW - Chickenpox
KW - Vitamin A in human nutrition
KW - Vitamin A deficiency
KW - Gastroenteritis
KW - Liver
KW - infection
KW - relative dose response
KW - Vitamin A status
N1 - Accession Number: 91731561; Campos, Florisbela A. C. S. 1; Flores, Hemando 1; Underwood, Barbara A. 2; Affiliations: 1: Laboratory of Nutritional Biochemistry, Department of Nutrition, Federal University of Pernambuco, Brazil; 2: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Jul1987, Vol. 46 Issue 1, p91; Thesaurus Term: Infection; Subject Term: Chickenpox; Subject Term: Vitamin A in human nutrition; Subject Term: Vitamin A deficiency; Subject Term: Gastroenteritis; Subject Term: Liver; Author-Supplied Keyword: infection; Author-Supplied Keyword: relative dose response; Author-Supplied Keyword: Vitamin A status; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Uphoff, Delta E.
T1 - Fetal and maternal tissues.
JO - American Scientist
JF - American Scientist
Y1 - 1987/07//Jul/Aug87
VL - 75
IS - 4
M3 - Letter
SP - 346
EP - 346
SN - 00030996
AB - Presents a letter to the editor commenting on John C. Rodger and Belinda L. Drake's article entitled 'The Enigma of the Fetal Graft.'
KW - Fetal tissue transplants
KW - Letters to the editor
N1 - Accession Number: 11232774; Uphoff, Delta E. 1; Affiliations: 1: National Cancer Institute, Bethesda, MD; Issue Info: Jul/Aug87, Vol. 75 Issue 4, p346; Subject Term: Fetal tissue transplants; Subject Term: Letters to the editor; Number of Pages: 1/4p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Westerhoff, Hans V.
T1 - In Search of the Physical Basis of Life (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1987/07//Jul/Aug87
VL - 75
IS - 4
M3 - Book Review
SP - 432
EP - 432
SN - 00030996
AB - Reviews the book 'In Search of the Physical Basis of Life,' by Gilbert N. Ling.
KW - Biology
KW - Nonfiction
KW - Ling, Gilbert N.
KW - In Search of the Physical Basis of Life (Book)
N1 - Accession Number: 11232814; Westerhoff, Hans V. 1; Affiliations: 1: National Institutes of Health; Issue Info: Jul/Aug87, Vol. 75 Issue 4, p432; Thesaurus Term: Biology; Subject Term: Nonfiction; Reviews & Products: In Search of the Physical Basis of Life (Book); People: Ling, Gilbert N.; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tung, K. S. K.
AU - Umland, Edith
AU - Matzner, P.
AU - Nelson, K.
AU - Schauf, Victoria
AU - Rubin, L.
AU - Wagner, D.
AU - Scollard, D.
AU - Vithayasai, Prakong
AU - Vithayasai, Vicharn
AU - Worobec, Sophie
AU - Smith, T.
AU - Vinai Suriyanond
T1 - Soluble serum interleukin 2 receptor levels in leprosy patients.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/07//
VL - 69
IS - 1
M3 - Article
SP - 10
EP - 15
PB - Wiley-Blackwell
SN - 00099104
AB - Soluble interleukin 2 receptors (IL-2R) in sera of leprosy patients from Chiang Mai, Thailand, were quantified with a solid phase enzyme immunoassay using two monoclonal antibodies to the IL-2R. The IL-2R levels of untreated lepromatous, borderline lepromatous or midborderline patients and treated lepromatous and borderline lepromatous or treated borderline tuberculoid and tuberculoid patients were comparable to those of the Thai household or nonhousehold contacts: and they were significantly higher than the levels of USA control subjects. In contrast. IL-2R of untreated tuberculoid or borderline tuberculoid patients were significantly reduced. Patients with ongoing reversal reaction had very high circulating IL-2R. the levels of which correlated with lever and extent of skin lesions. Although erythrema nodosum leprosum patients also had elevated IL-2R levels. they were significantly below those of patients with reversal reaction. When treated with corticosteroid. precipitous reduction of IL-2R was noted in all patients with reversal reaction but not in patients with erythema nodosum leprosum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - SERUM
KW - BLOOD plasma
KW - MYCOBACTERIAL diseases
KW - MONOCLONAL antibodies
KW - INTERLEUKIN-2
KW - interleukin 2 receptor.
KW - leprosy
KW - reversal reaction
N1 - Accession Number: 16183391; Tung, K. S. K. 1 Umland, Edith 1 Matzner, P. 1 Nelson, K. 2 Schauf, Victoria 2 Rubin, L. 3 Wagner, D. 3 Scollard, D. 4 Vithayasai, Prakong 4 Vithayasai, Vicharn 4 Worobec, Sophie 4 Smith, T. 4 Vinai Suriyanond 4; Affiliation: 1: Department of Pathology, University of New Mexico School of Medicine, Albuquerque. 2: Department of Preventive Medicine, University of Illinois, Chicago. 3: Immunology Section, Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda. 4: Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Source Info: Jul1987, Vol. 69 Issue 1, p10; Subject Term: IMMUNOGLOBULINS; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: MYCOBACTERIAL diseases; Subject Term: MONOCLONAL antibodies; Subject Term: INTERLEUKIN-2; Author-Supplied Keyword: interleukin 2 receptor.; Author-Supplied Keyword: leprosy; Author-Supplied Keyword: reversal reaction; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ansel, John C.
AU - Luger, Thomas A.
AU - Green, Ira
T1 - Fever and Increased Serum IL-1 Activity As a Systemic Manifestation of Acute Phototoxicity in New Zealand White Rabbits.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/07//
VL - 89
IS - 1
M3 - Article
SP - 32
EP - 37
SN - 0022202X
AB - Ultraviolet (UV) radiation is a significant environmental hazard for humans and animals. Although the clinical effect of an acute UV exposure such as cutaneous inflammation, malaise, somnolence, chills, and fever have been appreciated for many years, the underlying mechanisms mediating these effects are poorly understood. Since chills and fever are the most dramatic systemic sequelae after a prolonged exposure to UV, we specifically examined the effect of whole-body UV irradiation on core body temperature and serum endogenous pyrogen activity of New Zealand White rabbits, correlating this with serum interleukin I (IL-1) activity and alterations of serum divalent cation levels. We found that an acute dose of UV irradiation (Westinghouse FS-40 lamps, 0.2 mJ/cm2/s × 8 h) resulted in a significant increase in the core body temperature 2 h post UV (0.8°C), peaking 5 h post UV (1.8°C), and returning to normal 24 h post UV. Likewise, the sera from the UV-irradiated rabbits had significant endogenous pyrogen activity when transferred into naive recipient animals, causing an increase in core body temperature within 45 min (0.65 ± 0.12°C), decreasing over the next 2 h, and returning to normal 6 h post injection. No endotoxin contamination was detected in any serum samples. This post-UV febrile response was accompanied by a prolonged increase in serum IL-1 activity (5-10 X ) and a significant alteration in serum divalent cation levels, with the rabbits becoming euthermic even as the serum IL-I levels remained elevated. These findings provide new information concerning the pathogenesis and kinetics of these systemic effects after an acute dose of UV irradiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM
KW - INTERLEUKIN-1
KW - ULTRAVIOLET radiation
KW - SKIN -- Inflammation
KW - ENDOTOXINS
KW - BODY temperature
N1 - Accession Number: 12580362; Ansel, John C. 1 Luger, Thomas A. 2 Green, Ira 3; Affiliation: 1: Departments of Dermatology, Veterans Administration Medical Center and The Oregon Health Sciences University, Portland, Oregon, U.S.A. 2: Department of Dermatology, Ludvig Bolstsmnan Institute for Dermatovenerological Serodiagnosis, Laboratory for Cell Biology, University of Vienna, Vienna, Austria. 3: Laboratory of Immunology, National Institute of Allergy amid Infectious Diseases, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p32; Subject Term: SERUM; Subject Term: INTERLEUKIN-1; Subject Term: ULTRAVIOLET radiation; Subject Term: SKIN -- Inflammation; Subject Term: ENDOTOXINS; Subject Term: BODY temperature; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12580362
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagae, Shonosuke
AU - Lichti, Ulrike
AU - De Luca, Luigi M.
AU - Yuspa, Stuart H.
T1 - Effect of Retinoic Acid on Cornified Envelope Formation: Difference Between Spontaneous Envelope Formation In Vivo or In Vitro and Expression of Envelope Competence.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/07//
VL - 89
IS - 1
M3 - Article
SP - 51
EP - 58
SN - 0022202X
AB - A large number of cross-linked envelopes form spontaneously when cell lines derived from chemically induced mouse skin papillomas are cultured in medium containing 1.2 mM calcium. This phenomenon is associated with high activity of the cross-linking enzyme, epidermal transglutamjnase (TGase). The influence of retinoic acid (RA) on envelope formation was studied in detail in a papilloma cell line, PE. Retinoic acid (3 μM) completely blocked cornified envelope (CE) production but reduced TGase activity only 50%. A rabbit antiserum was produced against sonicated CEs isolated from newborn mouse skin. On Western blots of epidermal extracts, diffuse staining was observed for particulate proteins of suprabasal, but not basal, cells and similar immunoreactive material was absent from the cytosolic fraction of both cell layers. The antibody also recognized particulate proteins from PE cells induced to differentiate by calcium, but not from cells grown in the presence of high calcium and RA. The antiserum appears to recognize partially cross-linked CE precursor proteins judging by the diffuse staining, the molecular weight range of the proteins stained, and their origin in the particulate cellular fraction. Cross-linked envelopes could be induced in RA-treated PE cells by permeabilization with 0.75 M NaCI or 50 μg/ml A23187. However, this treatment failed to cause the appearance of proteins recognized by the antiserum. Preincubation of the antiserum with purified fragments of CEs from newborn mouse epidermis, but not with cross-linked envelopes from permeabilized, RA-treated PE cells, removed immunoreactivity. These results indicate that the cross-linked envelopes formed in RA-treated cells after permeabilization lack a set of proteins contained in CEs from stratum corneum and may even be composed of different proteins. Retinoic acid appears to prevent CE formation in part by inhibiting activation of epidermal TGase but in addition by influencing the synthesis of precursor proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRETINOIN
KW - CALCIUM
KW - TRANSGLUTAMINASES
KW - SERUM
KW - EPIDERMIS
KW - PROTEIN precursors
N1 - Accession Number: 12580383; Nagae, Shonosuke 1 Lichti, Ulrike 1 De Luca, Luigi M. 1 Yuspa, Stuart H. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p51; Subject Term: TRETINOIN; Subject Term: CALCIUM; Subject Term: TRANSGLUTAMINASES; Subject Term: SERUM; Subject Term: EPIDERMIS; Subject Term: PROTEIN precursors; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12580383
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Falanga, Vincent
AU - Tiegs, Susan L.
AU - Alstadt, Stephanie P.
AU - Roberts, Anita B.
AU - Sporn, Michael B.
T1 - Transforming Growth Factor-Beta: Selective Increase in Glycosaminoglycan Synthesis by Cultures of Fibroblasts From Patients With Progressive Systemic Sclerosis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/07//
VL - 89
IS - 1
M3 - Article
SP - 100
EP - 104
SN - 0022202X
AB - Transforming growth factor-beta (TGF-beta) has been found in all cells examined thus far, and has been shown to play an important role in inflammation and connective tissue formation. We now report that TGF-beta, alone or in combination with epidermal growth factor (EGF), led to a preferential increase in glycosaminoglycan synthesis by cultures of dermal fibroblasts from patients with progressive systemic sclerosis (PSS) when compared with normal fibroblasts (p < 0.001). Transforming growth factor-beta increased collagen synthesis to the same extent in both PSS and normal fibroblasts, whereas EGF had no stimulatory activity on collagen synthesis. The addition of EGE to cultures incubated with TGF-beta led to a decrease in collagen synthesis compared with the effect seen with TGF-beta alone (p <0.02). These studies suggest that TGF-beta may play an important role in the accumulation of connective tissue seen in PSS and that the combined action of multiple growth factors may modulate the synthetic activity of human dermal fibroblasts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GROWTH factors
KW - CYTOKINES
KW - GLYCOSAMINOGLYCANS
KW - FIBROBLASTS
KW - SYSTEMIC scleroderma
KW - MUCOPOLYSACCHARIDES
N1 - Accession Number: 12580445; Falanga, Vincent 1 Tiegs, Susan L. 1 Alstadt, Stephanie P. 1 Roberts, Anita B. 2 Sporn, Michael B. 2; Affiliation: 1: Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 2: National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p100; Subject Term: GROWTH factors; Subject Term: CYTOKINES; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: FIBROBLASTS; Subject Term: SYSTEMIC scleroderma; Subject Term: MUCOPOLYSACCHARIDES; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12580445
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raynaud, Françoise
AU - Leduc, Claire
AU - Anderson, Wayne B.
AU - Evain-Brion, Danièle
T1 - Retinoid Treatment of Human Psoriatic Fibroblasts Induces an Increase in Cyclic AMP-Dependent Protein Kinase Activity.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/07//
VL - 89
IS - 1
M3 - Article
SP - 105
EP - 110
SN - 0022202X
AB - We recently showed a deficiency of cyclic AMP (cAMP)- dependent protein kinases in psoriatic cells. In this work the effects of retinoids on cAMP-dependent protein kinases of fibroblasts from 7 normal subjects and 7 psoriatic patients were studied. The levels of RI and RII (two forms of the cAMP-dependent protein kinases) present in control and retinoic acid-treated cells were quantitated by photoaffinity labeling with [8-azido-32P]cAMP. In psoriatic fibroblasts the levels of Rh are decreased or undetectable compared with those of normal fibroblasts both in the cytosolic and membrane fractions. The amount of RI was normal in the cytosol of fibroblasts of 5 out of 7 patients and decreased in 2 patients. Membrane-associated levels of RI were decreased in 5 patients and normal in 2 patients. Retinoic acid treatment induces an increase in the amount of RI and RII regulatory subunits when they are deficient in the cytosolic and membrane fractions of psoriatic fibroblasts. Retinoic acid had no effect on RI and Rh in normal fibroblasts. In addition, with in vitro retinoic acid treatment the cAMP-dependent protein kinase activity, measured in the fibroblasts of 4 psoriatic patients, was increased in the cytosol in 2 patients and in the membranes in all 4 patients. In these studies, comparable results were obtained with fibroblasts cultured from involved and uninvolved skin. This in vitro effect of retinoids on cAMP-dependent protein kinases in psoriatic fibroblasts may help to explain some of the in vivo therapeutic effects of retinoids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETINOIDS
KW - FIBROBLASTS
KW - CONNECTIVE tissue cells
KW - PROTEIN kinases
KW - PHOSPHOTRANSFERASES
KW - DITERPENES
N1 - Accession Number: 12580448; Raynaud, Françoise 1 Leduc, Claire 1 Anderson, Wayne B. 2 Evain-Brion, Danièle 1; Affiliation: 1: Unite INSERM 188, Paris, France, 2: Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Jul87, Vol. 89 Issue 1, p105; Subject Term: RETINOIDS; Subject Term: FIBROBLASTS; Subject Term: CONNECTIVE tissue cells; Subject Term: PROTEIN kinases; Subject Term: PHOSPHOTRANSFERASES; Subject Term: DITERPENES; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12580448
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06450-047
AN - 2006-06450-047
AU - Ingraham, Loring J.
T1 - A Medical Approach to Psychodiagnosis.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/07//
VL - 32
IS - 7
SP - 659
EP - 660
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06450-047. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Ingraham, Loring J.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychiatry; Psychodiagnosis; Testing. Minor Descriptor: Mental Disorders. Classification: Clinical Psychological Testing (2224); Psychological & Physical Disorders (3200). Population: Human (10). Reviewed Item: Gold, Mark S. (Ed); Pottash, A. L. C. (Ed). Diagnostic and Laboratory Testing in Psychiatry=New York: Plenum Press, 1986. 299 pp. 32.50; 1986. Page Count: 2. Issue Publication Date: Jul, 1987.
AB - Reviews the book, Diagnostic and Laboratory Testing in Psychiatry edited by Mark S. Gold and A. L. C. Pottash (1986). The editors of this book take aim at the diagnostic practices of their psychiatric colleagues and find them wanting. The editors propose that the appropriate use of newer laboratory tests can successfully separate psychiatric illness from other medical illnesses and that the results of laboratory testing can be used to specify appropriate treatment. The chapters are successful in cogently explicating a variety of physical illnesses masquerading as psychiatric illness. The contributors optimistically present a number of laboratory tests with the potential to both differentiate psychiatric illness from identifiable organic illnesses and identify treatment (psychopharmacological) responders. This volume may thus be useful to both clinicians and investigators, it can educate clinicians in how to request appropriate medical consultation in their practice and can suggest to investigators avenues for collaborative approaches to psychodiagnosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric illness
KW - laboratory tests
KW - laboratory testing
KW - medical illnesses
KW - psychiatry
KW - psychodiagnosis
KW - 1987
KW - Psychiatry
KW - Psychodiagnosis
KW - Testing
KW - Mental Disorders
KW - 1987
U2 - Gold, Mark S. (Ed); Pottash, A. L. C. (Ed). (1986); Diagnostic and Laboratory Testing in Psychiatry; New York: Plenum Press, 1986. 299 pp. 32.50; 0-306-42054-6.
DO - 10.1037/027333
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Corda, Daniela
AU - Sekura, Ronald D.
AU - Kohn, Leonard D.
T1 - Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/07/15/
VL - 166
IS - 2
M3 - Article
SP - 475
EP - 481
PB - Wiley-Blackwell
SN - 00142956
AB - Incubation of FRTL-5 rat thyroid cell membranes with [32P]NAD and pertussis toxin results in the specific ADP-ribosylation of a protein of about 40 kDa. This protein has the same molecular mass of the αi subunit of the adenylate cyclase regulatory protein Ni and is distinct from proteins ADP-ribosylated by cholera toxin in the same membranes. Prior treatment of FRTL-5 cells with pertussis toxin results in the ADP-ribosylation of Ni, as indicated by the loss of the toxin substrate in the ADP-ribosylation assay performed with membranes prepared from such cells. Preincubation of FRTL-5 cells with thyrotropin causes the same loss; cholera toxin has no such effect. Pertussis toxin, as do thyrotropin and cholera toxin, increases cAMP levels in FRTL-5 cells. Forskolin together with thyrotropin, cholera toxin or pertussis toxin causes a further increase in cAMP levels. Petussis toxin and thyrotropin are not additive in their ability to increase adenylate cyclase activity, whereas both substances are additive with cholera toxin. A role of Ni in the thyrotropin regulation of the adenylate cyclase activity in thyroid cells is proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROTROPIN
KW - GLYCOPROTEIN hormones
KW - PITUITARY hormones
KW - ADENOSINE diphosphate
KW - PERTUSSIS toxin
KW - BACTERIAL toxins
N1 - Accession Number: 13801311; Corda, Daniela 1,2 Sekura, Ronald D. 3 Kohn, Leonard D. 1; Affiliation: 1: Section on Cell Regulation, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 2: Istituto di Ricerche Farmacologiche 'Mario Negri', Milano, Italy 3: Laboratory of Development and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 7/15/87, Vol. 166 Issue 2, p475; Subject Term: THYROTROPIN; Subject Term: GLYCOPROTEIN hormones; Subject Term: PITUITARY hormones; Subject Term: ADENOSINE diphosphate; Subject Term: PERTUSSIS toxin; Subject Term: BACTERIAL toxins; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ARRIZA, JEFFREY L.
AU - WEINBERGER, CARY
AU - CERELLI, GAIL
AU - GLASER, TOM M.
AU - HANDELIN, BARBARA L.
AU - HOUSMAN, DAVID E.
AU - EVANS, RONALD M.
T1 - Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor.
JO - Science
JF - Science
Y1 - 1987/07/17/
VL - 237
IS - 4812
M3 - Article
SP - 268
EP - 275
SN - 00368075
AB - Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide. Expression studies demonstrate its ability to bind aldosterone with high affinity and to activate gene transcription in response to aldosterone, thus establishing its identity as the human mineralocorticoid receptor (hMR). This molecule also shows high affinity for glucocorticoids and stimulates a glucocorticoid-responsive promoter. Together the hMR and hGR provide unexpected functional diversity in which hormone-binding properties, target gene interactions, and patterns of tissue-specific expression may be used in a combinatorial fashion to achieve complex physiologic control. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87436224; ARRIZA, JEFFREY L. 1,2 WEINBERGER, CARY 3,4 CERELLI, GAIL 3 GLASER, TOM M. 5 HANDELIN, BARBARA L. 5 HOUSMAN, DAVID E. 5 EVANS, RONALD M. 3; Affiliation: 1: University of California at San Diego, Department of Biology, LaJolla, CA 92093 2: Gcne Expression Laboratory, The Salk Institute for Biofogical Studies, P.O. Box 85800, San Diego CA 92138 3: Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA 92138 4: National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 5: Massachusetts Institute of Technology, Center for Cancer Research, Cambridge, MA 02139; Source Info: 7/17/1987, Vol. 237 Issue 4812, p268; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Albanes, Demetrius
AU - Garn, Stanley M.
AU - Leonard, William R.
AU - Hawthorne, Victor
T1 - Three limitations of the body mass index.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/08//
VL - 46
IS - 2
M3 - Article
SP - 376
EP - 377
SN - 00029165
AB - A letter to the editor is presented in response to the article related to the limitation of the body mass index in the anthropometry.
KW - Body mass index
KW - Anthropometry
N1 - Accession Number: 91655096; Micozzi, Marc S. 1; Albanes, Demetrius 2; Garn, Stanley M. 3; Leonard, William R. 3; Hawthorne, Victor 3; Affiliations: 1: Armed Forces Institutes of Pathology Washington, DC 30306-6000; 2: Cancer Prevention Studies Branch, National Cancer Institute, Blair Bldg, Rm 6A-09, Bethesda, MD 20892-4200; 3: Center for Human Growth, University of Michigan, Nutrition Unit, School of Public Health and Department of Epidemiology, Ann Arbor, MI 48109; Issue Info: Aug1987, Vol. 46 Issue 2, p376; Subject Term: Body mass index; Subject Term: Anthropometry; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ranki, Annamari
AU - Weiss, S. H.
AU - Valle, Sirkka-Liisa
AU - Antonen, J.
AU - Krohn, K. J.
T1 - Neutralizing antibodies in HIV (HTLV-III) infection: correlation with clinical outcome and antibody response against different viral proteins.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/08//
VL - 69
IS - 2
M3 - Article
SP - 231
EP - 239
PB - Wiley-Blackwell
SN - 00099104
AB - Sequential serum samples, collected over a 2- 3 year follow-up period, of 28 HIV-infected individuals were tested for the presence of neutralizing antibodies against one HIV isolate, HTLV-IIIB. and titrated, by Western blotting, against different HTLV-III specific proteins. Neutralizing antibodies were found in 66% of the samples tested and highest neutralization titres observed in cases with lymphadenopathy syndrome. Antibody titres against the viral proteins also seemed to be highest in cases with LAS. Neutralization titres correlated well with antibodies to envelope glycoproteins gp4l and gpl20 and to one of the core proteins. pl7. An increase in neutralization titre during the follow-up period was associated with a stable clinical course. Furthermore, the occurrence of antibodies directed against the external envelope glycoprotein (gpl20) in the initial scrum sample correlated well with a stable clinical course. The results suggest that neutralizing activity in the scrum, particularly that evoked against gpl20. may have some prognostic significance. and that several distinct antigenic epitopes on the virus may be a target for neutralizing antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM
KW - BLOOD plasma
KW - MICROBIAL proteins
KW - ANTIGENIC determinants
KW - VIRUSES
KW - AIDS (Disease)
KW - HTLV-III infection neutralizing antibodies gp120
N1 - Accession Number: 16141784; Ranki, Annamari 1,2 Weiss, S. H. 3 Valle, Sirkka-Liisa 2 Antonen, J. 4 Krohn, K. J. 1,4; Affiliation: 1: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesa, Maryalnd. 2: Department of Dermatology, University of Helsinki, Helsinki, Finland. 3: Environmental Epidemiology Branch, National Cancer Institute, Bethesa, Maryland, USA. 4: Institute of Biomedical Sciences, University of Tampere, Tampere, Finland.; Source Info: Aug1987, Vol. 69 Issue 2, p231; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: MICROBIAL proteins; Subject Term: ANTIGENIC determinants; Subject Term: VIRUSES; Subject Term: AIDS (Disease); Author-Supplied Keyword: HTLV-III infection neutralizing antibodies gp120; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chopra, R. K.
AU - Nagel, J. E.
AU - Chrest, F. J.
AU - Boto, W. M.
AU - Pyle, R. S.
AU - Dorsey, Barbara
AU - McCoy, M.
AU - Holbrook, Nikki
AU - Adler, W. H.
T1 - Regulation of interleukin 2 and interleukin 2 receptor gene expression in human T cells: 1. effect of Ca22+ -- ionophore on phorbol myristate acetate co-stimulated cells.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/08//
VL - 69
IS - 2
M3 - Article
SP - 433
EP - 440
PB - Wiley-Blackwell
SN - 00099104
AB - Human peripheral blood T lymphocytes were treated with phorbol myristate acetate (PMA), an activator of protein kinase C (PKC) activity, and with the calcium ionophore A23187. The resulting accumulation of specific mRNA for interleukin 2 (IL-2) and interleukin 2 receptor (IL-2R), as well as IL-2 secretion and membrane IL-2R expression were examined. At low concentrations (0.1 μM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion. A high concentration of A23187 (1.0 μM) did not show any synergism for the accumulation of IL-2R mRNA, membrane IL-2R expression and inhibited the proliferation of PMA co-stimulated T cells. It did, however, induce maximum accumulation of IL-2 mRNA and IL-2 secretion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESSENGER RNA
KW - T cells
KW - GENE expression
KW - GENETIC regulation
KW - PROTEIN kinases
KW - PROTEIN kinase C
KW - Ca ionophore phorbol myristate acetate lymphocytes interleukin 2
N1 - Accession Number: 16142246; Chopra, R. K. 1 Nagel, J. E. 1 Chrest, F. J. 1 Boto, W. M. 1 Pyle, R. S. 1 Dorsey, Barbara 1 McCoy, M. 2 Holbrook, Nikki 2 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology research Center, National Institute on Aging, National Institute of Health, Baltimore, Maryland. 2: Laboratory of Molecular Genetics, Gerontology research Center, National Institute on Aging, National Institute of Health, Baltimore, Maryland.; Source Info: Aug1987, Vol. 69 Issue 2, p433; Subject Term: MESSENGER RNA; Subject Term: T cells; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: PROTEIN kinases; Subject Term: PROTEIN kinase C; Author-Supplied Keyword: Ca ionophore phorbol myristate acetate lymphocytes interleukin 2; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolfe, Mary D.
AU - Carlos, James P.
T1 - Oral health effects of smokeless tobacco use in Navajo Indian adolescents.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1987/08//
VL - 15
IS - 4
M3 - Article
SP - 230
EP - 235
SN - 03015661
AB - Recent reports have suggested that the use of smokeless tobacco is increasing in adolescents, and is particularly high in Native Americans, causing concern about possible effects on oral health. In this study, 226 Navajo Indians, aged 14-19, were interviewed regarding their use of smokeless tobacco (ST), cigarettes, and alcohol, Midbuccal and mesiobuccal sites on all fully erupted permanent teeth (excluding third molars) were examined for the presence of gingival bleeding, gingival recession, calculus, and loss of periodontal attachment. The oral mucosa was examined for evidence of leukoplakia. 64.2% (145) of the subjects (75.4% of the boys and 49.0% of the girls) were users of ST. Of these, over 95% used snuff alone or in combination with chewing tobacco. 55.9% used ST one or more days per week. 52.2% consumed alcohol, usually beer or wine, and 54.0% smoked cigarettes. 25.5% (37) of the users and 3.7% (3) of the non-users had leukoplakia. The duration (in years) and frequency of ST use (days per week) were highly significant risk factors associated with leukoplakia. However, the concomitant use of alcohol or cigarettes did not appear to increase the prevalence of these lesions. No consistent relationship was observed between the use of ST and gingival bleeding, calculus, gingival recession, or attachment loss, either when comparing users to non-users or when comparing the segment where the tobacco quid was habitually placed to a within-subject control segment. In view of these results, there is little doubt that smokeless tobacco is significantly related to the etiology of leukoplakia. As some evidence exists that smokeless tobacco use is a significant risk factor associated with oral carcinoma, intervention programs to discourage the use of smokeless tobacco by adolescents should be a public health priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION & dental health
KW - SMOKELESS tobacco
KW - TEENAGERS
KW - GUM disease
KW - ORAL mucosa
KW - PUBLIC health
KW - INDIA
KW - adolescence; Indians
KW - leukoplakia
KW - Navajo
KW - North American
KW - periodontal diseases
KW - smokeless tobacco
N1 - Accession Number: 12014464; Wolfe, Mary D. 1 Carlos, James P. 1; Affiliation: 1: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research National Institutes of Health, Bethesda Maryland, USA; Source Info: Aug1987, Vol. 15 Issue 4, p230; Subject Term: NUTRITION & dental health; Subject Term: SMOKELESS tobacco; Subject Term: TEENAGERS; Subject Term: GUM disease; Subject Term: ORAL mucosa; Subject Term: PUBLIC health; Subject Term: INDIA; Author-Supplied Keyword: adolescence; Indians; Author-Supplied Keyword: leukoplakia; Author-Supplied Keyword: Navajo; Author-Supplied Keyword: North American; Author-Supplied Keyword: periodontal diseases; Author-Supplied Keyword: smokeless tobacco; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12014464
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emonard, Hervé
AU - Calle, Aleth
AU - Grimaud, Jean-Alexis
AU - Peyrol, Simone
AU - Castronovo, Vincent
AU - Noel, Agnès
AU - Lapière, Charles M.
AU - Kleinman, Hynda K.
AU - Foidart, Jean-Michel
T1 - Interactions Between Fibroblasts and a Reconstituted Basement Membrane Matrix.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/08//
VL - 89
IS - 2
M3 - Article
SP - 156
EP - 163
SN - 0022202X
AB - A gel-like reconstituted basement membrane matrix containing type IV collagen, laminin, entactin, nidogen, and heparan sulfate proteoglycan was used to examine the interactions between normal calf skin fibroblasts and basement membranes. Within 6 h after seeding, fibroblasts initiated a migration that resulted in the formation of a cellular network after 1 day of culture on top of the gel. Electron microscopy revealed that fibroblasts were able to remodel the basement membrane matrix by penetrating into the gel (from day 3), depositing fibronectin and collagen fibers, and retracting this extracellular matrix. Fibroblasts cultured on the Engelbreth-Holm-Swarm reconstituted basement membrane matrix displayed ultrastructural features characterized by a poor synthetic apparatus (rough endoplasmic reticulum and Golgi vesicles), a large cytoskeleton, and intracytoplasmic vesicles containing laminin. Thus the reconstituted basement membrane matrix is remodeled by skin fibroblasts, and reciprocally their ultrastructural morphologic features are affected by this matrix. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLAGEN
KW - EXTRACELLULAR matrix proteins
KW - PROTEOGLYCANS
KW - GLYCOPROTEINS
KW - FIBROBLASTS
KW - ENDOPLASMIC reticulum
N1 - Accession Number: 12470552; Emonard, Hervé 1 Calle, Aleth 1 Grimaud, Jean-Alexis 2 Peyrol, Simone 2 Castronovo, Vincent 1,3 Noel, Agnès 1 Lapière, Charles M. 1 Kleinman, Hynda K. 4 Foidart, Jean-Michel 1; Affiliation: 1: Laboratory of Experimental Dermatology and Pathophysiology of Pregnancy, University of Liège, Liège, Belgium. 2: Laboratory of Liver Cellular Pathology, C.N.R.S.-UA 602, Institut Pasteur, Lyon, France. 3: Department of Obstetrics and Gynecology, University of Liège, Liège, Belgium. 4: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug87, Vol. 89 Issue 2, p156; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: FIBROBLASTS; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12470552
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12470552&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hofferth, Sandra L.
AU - Phillips, Deborah A.
T1 - Child Care in the United States, 1970 to 1995.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1987/08//
VL - 49
IS - 3
M3 - Article
SP - 559
SN - 00222445
AB - As the proportion of children with mothers who are working has increased, so has the interest and concern about their care arrangements. This study utilizes trends in the proportion of children with a mother in the labor force along with trends in the number of children to project the proportion of children with employed mothers in 1990 and 1995, by age of child. The authors profile the current distribution of children in non parental care and look at trends over the past two decades. They then present the most recent information on current supply of child care and trends in that supply. Finally, implications of recent developments for the supply of and demand for child care in the future are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD care
KW - MICROECONOMICS
KW - PARENT & child
KW - LABOR supply
KW - MOTHERS
KW - UNITED States
N1 - Accession Number: 5274076; Hofferth, Sandra L. 1 Phillips, Deborah A. 2; Affiliation: 1: National Institute of Child Health and Human Development. 2: University of Virginia.; Source Info: Aug87, Vol. 49 Issue 3, p559; Subject Term: CHILD care; Subject Term: MICROECONOMICS; Subject Term: PARENT & child; Subject Term: LABOR supply; Subject Term: MOTHERS; Subject Term: UNITED States; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104761853
T1 - Family morbidity in chronic pain patients.
AU - Chaturvedi, S K
Y1 - 1987/08//1987 Aug
N1 - Accession Number: 104761853. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686.
KW - Mental Disorders
KW - Pain
KW - Adolescence
KW - Adult
KW - Chronic Disease
KW - Family
KW - Female
KW - Male
KW - Middle Age
KW - Pain -- Psychosocial Factors
SP - 159
EP - 168
JO - Pain (03043959)
JF - Pain (03043959)
JA - PAIN
VL - 30
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0304-3959
AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
U2 - PMID: 3670867.
DO - 10.1016/0304-3959(87)91071-2
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-06451-020
AN - 2006-06451-020
AU - Theodore, William H.
T1 - Does the Brain Really have Anything to do with Behavior?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/08//
VL - 32
IS - 8
SP - 720
EP - 720
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06451-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Theodore, William H.; Unit on Cerebral Blood Flow and Metabolism, Medical Neurology Branch, National Institutes of Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Brain; Drug Therapy; Psychopharmacology. Minor Descriptor: Medical Model; Mental Disorders. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Trimble, Michael R. (Ed). New Brain Imaging Techniques and Psychopharmacology=Oxford, England: Oxford University Press, 1986. 134 pp. $45.00; 1986. Page Count: 1. Issue Publication Date: Aug, 1987.
AB - Reviews the book, New Brain Imaging Techniques and Psychopharmacology edited by Michael R. Trimble (1986). Will the advent of functional images be the next great leap forward for the 'medical model' of psychiatric illness? Trimble and his colleagues attempt to show what has been achieved already. In subsequent chapters, contributors discuss primarily the contribution of PET to the evaluation of patients with psychiatric illness, reviewing the issue of decreased cerebral blood flow and metabolism in schizophrenia in some detail. Problems in research include diversity of the patient populations studied, as well as the possibility that decreased frontal glucose metabolism and blood flow ('hypofrontality') may be seen in chronic but not acute patients and are perhaps due to the effect of long-term antipsychotic therapy. Differences in statistical methods for data analysis, as well, may account for some of the variation in results. One of the difficulties in attempting to condense so much into such a small book is the inability to present conflicting viewpoints. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - brain imaging techniques
KW - psychopharmacology
KW - medical models
KW - psychiatric illness
KW - antipsychotic therapy
KW - 1987
KW - Brain
KW - Drug Therapy
KW - Psychopharmacology
KW - Medical Model
KW - Mental Disorders
KW - 1987
U2 - Trimble, Michael R. (Ed). (1986); New Brain Imaging Techniques and Psychopharmacology; Oxford, England: Oxford University Press, 1986. 134 pp. $45.00; 0-19-261525-4.
DO - 10.1037/027394
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06451-020&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06451-040
AN - 2006-06451-040
AU - Kleinman, Joel E.
T1 - An Introductory Text for Neuropsychologists.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/08//
VL - 32
IS - 8
SP - 744
EP - 745
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06451-040. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kleinman, Joel E.; Neuropathology Section, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Nervous System Disorders; Neuroanatomy; Neuropathology; Neuropsychological Assessment. Classification: Neuropsychological Assessment (2225); Neurological Disorders & Brain Damage (3297). Population: Human (10). Reviewed Item: Reitan, Ralph M.; Wolfson, Deborah. Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists=Tucson, AZ: Neuropsychology Press, 1985. 353 pp. $39.95; 1985. Page Count: 2. Issue Publication Date: Aug, 1987.
AB - Reviews the book, Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists by Ralph M. Reitan and Deborah Wolfson (1985). This textbook on neuroanatomy and neuropathology is written for neuropsychologists. Divided into four sections (introduction, neuroanatomy and neuropathology, diagnostic tests, and neurologic diseases), it is an excellent, although somewhat uneven, attempt. The introduction is concise, easy to read, and informative. The section on neuroanatomy and neuropathology is also well written. In addition, the diagrams are clear, useful, and accurate. In general, this is an excellent rating as a useful introduction for neuropsychologists in a field that needs their input. Insofar as it makes this possible, this book is a valuable and welcome addition to the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroanatomy
KW - neuropathology
KW - diagnostic tests
KW - neurologic diseases
KW - 1987
KW - Nervous System Disorders
KW - Neuroanatomy
KW - Neuropathology
KW - Neuropsychological Assessment
KW - 1987
U2 - Reitan, Ralph M.; Wolfson, Deborah. (1985); Neuroanatomy and Neuropathology: A Clinical Guide for Neuropsychologists; Tucson, AZ: Neuropsychology Press, 1985. 353 pp. $39.95; 0-934515-03-4.
DO - 10.1037/027414
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06451-040&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Levinger, Louis F.
AU - Lautenberger, James A.
T1 - Human protein binding to DNA sequences surrounding the human T-cell lymphotropic virus type-I long terminal repeat polyadenylation site.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/08/03/
VL - 166
IS - 3
M3 - Article
SP - 519
EP - 526
PB - Wiley-Blackwell
SN - 00142956
AB - The long terminal repeats (LTRs) of RNA tumor viruses, including human T-cell lymphotropic virus type I (HTLV-I), contain the control elements for expression of viral genes. Sequence-specific LTR-DNA-binding proteins could regulate viral functions. To search for such proteins we have used an in vitro non-denaturing polyacrylamide gel assay, with restriction fragments of the HTLV-I LTR and nuclear protein extracts from several HTLV-I-infected cell lines and an uninfected T-cell line, H9. Four DNA-binding activities were observed, including non-specific DNA-binding activity and at least two activities (forms I and II) which bind specifically to a HinfI restriction fragment from nucleotides + 181 to + 334 relative to the transcription start site. DNA-binding activities I and II were partially resolved by ion-exchange chromatography and mapped by protection experiments to two 10-20-bp blocks surrounding the polyadenylation site at + 221. Of the cell lines tested, form II was abundantly found in C10/MJ, and forms I and IV were also found in C91/PL, C81-66-45, MT2 and H9 cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN binding
KW - NUCLEOTIDE sequence
KW - HTLV-I (Virus)
KW - HTLV (Viruses)
KW - RETROVIRUSES
KW - ONCOGENIC viruses
KW - RNA viruses
KW - BIOCHEMISTRY
N1 - Accession Number: 13901772; Levinger, Louis F. 1 Lautenberger, James A. 2; Affiliation: 1: School of Life and Health Sciences, University of Delaware, Newark 2: Laboratory of Molecular Oncology, National Cancer Institute, Frederick; Source Info: 8/3/87, Vol. 166 Issue 3, p519; Subject Term: PROTEIN binding; Subject Term: NUCLEOTIDE sequence; Subject Term: HTLV-I (Virus); Subject Term: HTLV (Viruses); Subject Term: RETROVIRUSES; Subject Term: ONCOGENIC viruses; Subject Term: RNA viruses; Subject Term: BIOCHEMISTRY; Number of Pages: 8p; Illustrations: 4 Diagrams, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GARVER, JR., ROBERT I.
AU - CHYTIL, ANNA
AU - COURTNEY, MICHAEL
AU - CRYSTAL, RONALD G.
T1 - Clonal Gene Therapy: Transplanted Mouse Fibroblast Clones Express Human α1-Antitrypsin Gene in Vivo.
JO - Science
JF - Science
Y1 - 1987/08/14/
VL - 237
IS - 4816
M3 - Article
SP - 762
EP - 764
SN - 00368075
AB - A retroviral vector was used to insert human α1-antitrypsin (α1AT) complementary DNA into the genome of mouse fibroblasts to create a clonal population of mouse fibroblasts secreting human α1AT. After demonstrating that this clone of fibroblasts produced α1AT after more than 100 population doublings in the absence of selection pressure, the done was transplanted into the peritoneal cavities of nude mice. When the animals were evaluated 4 weeks later, human α1AT was detected in both sera and the epithelial surface of the lungs. The transplanted clone of fibroblasts could be recovered from the peritoneal cavities of those mice and demonstrated to still be producing human α1AT. Thus, even after removal of selective pressure, a single clone of retroviral vector-infected celis that expressed an exogenous gene in vitro, continued to do so in vivo, and when recovered, continued to produce the product of the exogenous gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519539; GARVER, JR., ROBERT I. 1,2 CHYTIL, ANNA 1,2 COURTNEY, MICHAEL 1,2 CRYSTAL, RONALD G. 1,2; Affiliation: 1: Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 2: Transgene SA, 11 Rue de Molsheim, 67000 Strasbourg, France; Source Info: 8/14/1987, Vol. 237 Issue 4816, p762; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MILLER, LOUIS H.
AU - SAKAI, RICHARD K.
AU - ROMANS, PATRICIA
AU - GWADZ, ROBERT W.
AU - KANTOFF, PHILIP
AU - COON, HAYDEN G.
T1 - Stable Integration and Expression of a Bacterial Gene in the Mosquito Anopheles gambiae.
JO - Science
JF - Science
Y1 - 1987/08/14/
VL - 237
IS - 4816
M3 - Article
SP - 779
EP - 781
SN - 00368075
AB - Foreign DNA was successfully introduced into the germline of the African mosquito vector of malaria Anophelesgambiae. Stable integration of genes into the germlines of insects had been achieved previously only in Drosophila melanogaster and related species and required the use of the P element transposon. In these experiments with Anopheles gambiae, the plasmid pUChsneo was used, which contains the selectable marker neo gene flanked by P element inverted repeats. Mosquitoes injected with this plasmid were screened for resistance to the neomycin analog G-418. A single event of plasmid insertion was recovered. Integration appears to be stable and, thus far, resistance to G- 418 has been expressed for eight generations. The transformation event appears to be independent of P. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519563; MILLER, LOUIS H. 1 SAKAI, RICHARD K. 1 ROMANS, PATRICIA 1 GWADZ, ROBERT W. 1 KANTOFF, PHILIP 2 COON, HAYDEN G. 3; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 2: Laboratorv of Molecular Hematology, National Heart, Lung and Blood Institute, Bethesda, MD 20892 3: Laboratorv of Genetics, National Cancer Institute, Bethesda, MD 20892; Source Info: 8/14/1987, Vol. 237 Issue 4816, p779; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Slade, John
AU - Connolly, Gregory
AU - Kazandjian, Vahe A.
AU - Albanes, Demetrius
AU - Jones, D. Yvonne
AU - Micozzi, Marc S.
AU - Martson, Margaret E.
AU - Newman, David M.
AU - Sorlie, Paul D.
T1 - Nicotine from Aerosol Rod.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/09//
VL - 77
IS - 9
M3 - Letter
SP - 1229
EP - 1229
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article “The delivery and uptake of nicotine from an aerosol rod," by D. W. Sepkovic that appeared in the previous issue of the journal "American Journal of Public Health."
KW - LETTERS to the editor
KW - NICOTINE
N1 - Accession Number: 4949820; Slade, John 1 Connolly, Gregory 2 Kazandjian, Vahe A. 3 Albanes, Demetrius 4 Jones, D. Yvonne 4 Micozzi, Marc S. 5 Martson, Margaret E. 6 Newman, David M. 7 Sorlie, Paul D. 8; Affiliation: 1: Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick 08903 2: Director, Division of Dental Health, Massachusetts Department of Public Health, Boston 02111 3: School of Public Health, University of Michigan, Ann Arbor 4: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, NIH, Bethesda, MD 5: Armed Forces Institutes of Pathology, Washington, DC 6: Office of the Director, Division of Cancer Prevention and Control, NCI, NIH, Bethesda, MD 7: Oak Orchard Community Health Center, 80 West Avenue, Brockport, NY 14420 8: Statistician (Health), Field Studies and Biometry Branch, Epidemiology and Biometry Research Program, Division of Epidemiology and Clinical Applications, NIH, NHLBI, Bethesda, MD 20892; Source Info: Sep87, Vol. 77 Issue 9, p1229; Subject Term: LETTERS to the editor; Subject Term: NICOTINE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wetzel, Mary G.
T1 - A Natural History of Sex: The Ecology and Evolution of Sexual Behavior (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1987/09//Sep/Oct87
VL - 75
IS - 5
M3 - Book Review
SP - 532
EP - 533
SN - 00030996
AB - Reviews the book 'A Natural History of Sex: The Ecology and Evolution of Sexual Behavior,' by Adrian Forsyth.
KW - Human sexuality
KW - Nonfiction
KW - Forsyth, Adrian
KW - Natural History of Sex, A (Book)
N1 - Accession Number: 11317696; Wetzel, Mary G. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: Sep/Oct87, Vol. 75 Issue 5, p532; Subject Term: Human sexuality; Subject Term: Nonfiction; Reviews & Products: Natural History of Sex, A (Book); People: Forsyth, Adrian; Number of Pages: 21p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wetzel, Mary G.
T1 - The Retina: A Model for Cell Biology Studies (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1987/09//Sep/Oct87
VL - 75
IS - 5
M3 - Book Review
SP - 534
EP - 534
SN - 00030996
AB - Reviews the book 'The Retina: A Model for Cell Biology Studies,' edited by Ruben Adler and Debora Faber.
KW - Retina
KW - Nonfiction
KW - Retina, The (Book)
N1 - Accession Number: 11317697; Wetzel, Mary G. 1; Affiliations: 1: Laboratory of Vision Research, National Eye Institute, National Institutes of Health; Issue Info: Sep/Oct87, Vol. 75 Issue 5, p534; Subject Term: Retina; Subject Term: Nonfiction; Reviews & Products: Retina, The (Book); Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fries, L. F.
AU - Siwik, S. A.
AU - Malbran, A.
AU - Frank, M. M.
T1 - Phagocytosis of target particles bearing C3b-IgG covalent complexes by human monocytes and polymorphonuclear leucocytes.
JO - Immunology
JF - Immunology
Y1 - 1987/09//
VL - 62
IS - 1
M3 - Article
SP - 45
EP - 51
PB - Wiley-Blackwell
SN - 00192805
AB - Immunoglobulin G (IgG) provides an efficient acceptor site for nascent C3b, and complement activation on the surface of IgG-coated bacteria has been shown to generate significant numbers of C3b-IgG complexes. We have studied the relative efficiency of IgG alone, C3b-IgG complexes, and similar densities of IgG and C3b residues deposited independently, in mediating ingestion of sheep erythrocyte (E) targets by human phagocytes. Human 125I-C3b covalently bound to rabbit anti-Forssman IgG was generated as described elsewhere (Fries et al., 1985). E, EIgMC4b, or EIgMC4b3b (prepared with IgM antibody and purified complement components) were sensitized with radiolabelled anti-Forssman IgG or C3b-IgG heterodimers to generate targets beating IgG alone, C3b-IgG covalent complexes, or C3b and IgG in equivalent numbers but not bound to each other. Phagocytosis by monocytes and polymorphonuclear leucocytes (PMN) of targets bearing C3b-IgG was markedly enhanced relative to those bearing IgG alone, especially at levels of < 2000 opsonin residues/target cell. Uptake of C3b-IgG-hearing targets was also significantly more resistant to competitive inhibition by ambient monomeric IgG. Phagocytosis of EIgMCAb+C3b-IgG by monocytes was superior to the uptake of either EAC4b + IgG or EAC4b3b + IgG bearing equivalent amounts of C3b and IgG not in covalent complex (P < 0·05, n = 10). Similar results were obtained with PMN Thus, generation of C3b-IgG complexes in vivo may not only promote complement activation and enhance C3b deposition, but also produce a compound opsonic residue which is a more potent promoter of phagocytosis than an equal number of C3b and IgG residues randomly distributed relative to each other. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN G
KW - ERYTHROCYTES
KW - PHAGOCYTES
KW - PHAGOCYTOSIS
KW - MONOCYTES
KW - NEUTROPHILS
N1 - Accession Number: 14015661; Fries, L. F. 1 Siwik, S. A. 1 Malbran, A. 1 Frank, M. M. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institutes of Health, Rockville Pike, Maryland, U.S.A.; Source Info: Sep87, Vol. 62 Issue 1, p45; Subject Term: IMMUNOGLOBULIN G; Subject Term: ERYTHROCYTES; Subject Term: PHAGOCYTES; Subject Term: PHAGOCYTOSIS; Subject Term: MONOCYTES; Subject Term: NEUTROPHILS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - King, Haitung
AU - Locke, Frances B.
T1 - Health Effects of Migration: U.S. Chinese In and Outside the Chinatown.
JO - International Migration Review
JF - International Migration Review
Y1 - 1987///Fall1987
VL - 21
IS - 3
M3 - Article
SP - 555
EP - 576
SN - 01979183
AB - A comparison of mortality among New York and San Francisco Chinatown residents and other Chinese Americans indicates that there is no clear relationship between migration and health risks. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Migration Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - EMIGRATION & immigration
KW - DEMOGRAPHY
KW - POPULATION
KW - DEATH
KW - CHINESE Americans
KW - CHINA
KW - IMMIGRATION AND MIGRATION
N1 - Accession Number: 16498655; King, Haitung 1; Locke, Frances B. 2; Affiliations: 1 : National Cancer Institute and Georgetown University.; 2 : National Cancer Institute.; Source Info: Fall1987, Vol. 21 Issue 3, p555; Historical Period: 1965 to 1975; Subject Term: HEALTH; Subject Term: EMIGRATION & immigration; Subject Term: DEMOGRAPHY; Subject Term: POPULATION; Subject Term: DEATH; Subject Term: CHINESE Americans; Subject: CHINA; Author-Supplied Keyword: IMMIGRATION AND MIGRATION; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Piegorsch, Walter W.
T1 - Model Robustness for Simultaneous Confidence Bands.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1987/09//
VL - 82
IS - 399
M3 - Article
SP - 879
SN - 01621459
AB - Confidence bands for the simple linear model are examined to assess their degrees of robustness to departures from the model. All calculations are made under an interval constraint on the range of interest for the predictor variable. The true model is taken to be a quadratic polynomial, and departure from the linear case is considered in terms of increasing magnitude of a curvature parameter. Proposed measures of robustness include the actual coverage probability under the true model and a measure of percentage coverage over the predictor variable axis when the band fails to cover the true quadratic model. The different band functions considered include hyperbolic bands constructed from Scheffe's S method, linear-segmented bands, and fixed-width (minimax) and minimax-regret bands. In terms of preserving coverage probability under quadratic misspecification, the fixed-width and linear-segment bands perform best, the former being preferred when the constraint interval on the predictor variable is small. When coverage is lost over some portion of the constraint interval, the fixed-width bands are also shown to preserve the greatest percentage of covered (predictor) axis values. The favorable performance of the fixed-width bands may be due to their generally wider, more rigid shape, relative to more curvilinear competitors. This may allow the bands to retain more extreme quadratic misspecifications than other bands. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - REGRESSION analysis
KW - MATHEMATICAL models
KW - LINEAR models (Statistics)
KW - SIMULATION methods & models
KW - QUADRATIC equations
KW - VARIABLES (Mathematics)
KW - ROBUST control
KW - Coverage probability
KW - Mean axis coverage
KW - Quadratic regression
KW - Simple linear regression.
N1 - Accession Number: 4605941; Piegorsch, Walter W. 1; Affiliations: 1: Mathematical Statistician, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.; Issue Info: Sep87, Vol. 82 Issue 399, p879; Thesaurus Term: PROBABILITY theory; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: SIMULATION methods & models; Subject Term: QUADRATIC equations; Subject Term: VARIABLES (Mathematics); Subject Term: ROBUST control; Author-Supplied Keyword: Coverage probability; Author-Supplied Keyword: Mean axis coverage; Author-Supplied Keyword: Quadratic regression; Author-Supplied Keyword: Simple linear regression.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rifkind, Basil M.
T1 - Diet, Cholesterol and coronary heart disease: the Lipid Research Clinics Program.
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
Y1 - 1987/09//
VL - 46
IS - 3
M3 - Article
SP - 367
EP - 372
SN - 00296651
N1 - Accession Number: 56764240; Rifkind, Basil M. 1; Affiliations: 1: Lipid Metabolism–Atherogenesis Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Issue Info: Sep1987, Vol. 46 Issue 3, p367; Number of Pages: 6p; Document Type: Article
L3 - 10.1079/PNS19870050
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lievrouw, Leah A.
AU - Rogers, Everett M.
AU - Lowe, Charles U.
AU - Nadel, Edward
T1 -
JO - Social Networks
JF - Social Networks
J1 - Social Networks
PY - 1987/09//
Y1 - 1987/09//
VL - 9
IS - 3
M3 - Article
SP - 217
SN - 03788733
AB - A triangulation strategy, employing a number of network analysis techniques, was implemented in the study of a single social network of biomedical scientists specializing in lipid metabolism research. Here we present the results of co-word analysis of grants awarded to these scientists by the National Institutes of Health, network analysis (NEGOPY) and factor analysis of the scientists' responses on a sociometric roster instrument, preliminary results of a co-citation analysis of their publications, and qualitative analysis of their responses to interviews and questionnaires. The findings are discussed in light of the relative information that the various techniques contribute to the understanding of the social relationships among the members of this scientific speciality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Networks is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL networksQUALITATIVE researchMEDICAL scientistsSOCIAL interactionUNIVERSITIES & collegesINTERVIEWS
N1 - Accession Number: 17189673; Issue Information: ; Subject Term: SOCIAL networks; Subject Term: QUALITATIVE research; Subject Term: MEDICAL scientists; Subject Term: SOCIAL interaction; Subject Term: UNIVERSITIES & colleges; Subject Term: INTERVIEWS; Subject Term: ; Number of Pages: 32p; ; Document Type: Article;
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DP - EBSCOhost
DB - bwh
ER -
TY - JOUR
ID - 2006-06452-036
AN - 2006-06452-036
AU - Myslobodsky, Michael S.
T1 - The Iceberg Above the Waterline.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/09//
VL - 32
IS - 9
SP - 818
EP - 819
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06452-036. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Myslobodsky, Michael S.; Clinical Brain Disorder Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Consciousness States. Classification: Consciousness States (2380). Population: Human (10). Reviewed Item: Wolman, Benjamin B. (Ed); Ullman, Montague (Ed). Handbook of States of Consciousness=New York: Van Nostrand Reinhold, 1986. 672 pp. $54.50; 1986. References Available: Y. Page Count: 2. Issue Publication Date: Sep, 1987.
AB - Reviews the book, Handbook of States of Consciousness edited by Benjamin B. Wolman and Montague Ullman (1986). The promise of this book is to give up-to-date information on the entire field of human consciousness. However, this volume was a disappointment to this reviewer, as it did not stand to this promise on either count. Yet, it would be naive to look for a contribution related to the recent thinking and/or research on consciousness in developmental psychobiology, artificial intelligence, linguistics, sensory psychology, anesthesiology, neurology, and neuropsychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consciousness states
KW - 1987
KW - Consciousness States
KW - 1987
U2 - Wolman, Benjamin B. (Ed); Ullman, Montague (Ed). (1986); Handbook of States of Consciousness; New York: Van Nostrand Reinhold, 1986. 672 pp. $54.50; 0-442-29456-5.
DO - 10.1037/027477
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06452-045
AN - 2006-06452-045
AU - Hadley, Suzanne W.
T1 - A Therapy Catalog.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/09//
VL - 32
IS - 9
SP - 826
EP - 827
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06452-045. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hadley, Suzanne W.; Extramural Policy Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Psychotherapists; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Kutash, Irwin L. (Ed); Wolf, Alexander (Ed). Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies=San Francisco: Jossey-Bass, 1986. 552 pp. $39.95; 1986. Page Count: 2. Issue Publication Date: Sep, 1987.
AB - Reviews the book, Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies edited by Irwin L. Kutash and Alexander Wolf (1986). The editors, Kutash and Wolf, were judicious in identifying the treatment approaches that would be represented. The gamut of major modalities are included in the book, with a sufficient level of subtyping so that important variations within broad approaches are treated separately. At the same time, the pitfall seen in other edited therapy compendia is avoided, namely, the inclusion of relatively rare, esoteric forms of treatment that have little interest for readers of a work such as this. The editors structured the task of the contributors to this volume exceedingly well. This truly is a 'casebook', the cases are engaging, readable, and revealing. The explication of theoretical substrates was kept to a minimum, with the case studies themselves used as a primary source of substantive input. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - therapies
KW - psychotherapists
KW - 1987
KW - Psychotherapists
KW - Treatment
KW - 1987
U2 - Kutash, Irwin L. (Ed); Wolf, Alexander (Ed). (1986); Psychotherapist's Casebook: Theory and Technique in the Practice of Modern Therapies; San Francisco: Jossey-Bass, 1986. 552 pp. $39.95; 0-87589-685-5.
DO - 10.1037/027486
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06452-045&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - REYNOLDS, STEVEN H.
AU - STOWERS, SHARI J.
AU - PATTERSON, RACHEL M.
AU - MARONPOT, ROBERT R.
AU - AARONSON, STUART A.
AU - ANDERSON, MARSHALL W.
T1 - Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications for Risk Assessment.
JO - Science
JF - Science
Y1 - 1987/09/11/
VL - 237
IS - 4820
M3 - Article
SP - 1309
EP - 1316
SN - 00368075
AB - The validity of mouse liver tumor end points in assessing the potential hazards of chemical exposure to humans is a controversial but important issue, since liver neoplasia in mice is the most frequent tumor target tissue end point in 2-year carcinogenicity studies. The ability to distinguish between promotion of background tumors versus a genotoxic mechanism of tumor initaton by chemical treatment would aid in the interpretation of rodent carcinogenesis data. Activated oncogenes in chemically induced and spontaneously occurring mouse liver tumors were examined and compared as one approach to determine the mechanism by which chemical treatment caused an increased incidence of mouse liver tumors. Data suggest that furan and furfural caused an increased incidence in mouse liver tumors at least in part by induction of novel weakly activating point mutations in ras genes even though both chemicals did not induce mutations in Salmonella assays. In addition to ras oncogenes, two activated raf genes and four non-ras transforming genes were detected. The B6C3F1 mouse liver may thus provide a sensitive assay system to detect various dasses of proto-oncogenes that are susceptible to activation by carcinogenic insult. As illustrated with mouse liver tumors, analysis of activated oncogenes in spontaneously occuring and chemically induced rodent tumors will provide information at a molecular level to aid in the use of rodent carcinogenesis data for risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519592; REYNOLDS, STEVEN H. 1 STOWERS, SHARI J. 1 PATTERSON, RACHEL M. 1 MARONPOT, ROBERT R. 2 AARONSON, STUART A. 3 ANDERSON, MARSHALL W. 1; Affiliation: 1: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Post Office Box 12233, Research Triangle Park, NC 27709 2: National Toxicologv Program, National Institute of Environmental Health Sciences, Post Office Box 12223, Research Triangle Park, NC 27709 3: Laboratory of Cellular and Molecular Biology, National Institutes of Health, Bethesda, MD 20205; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1309; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NERENBERG, MICHAEL
AU - HINRICHS, STEVEN H.
AU - REYNOLDS, R. KAY
AU - KHOURY, GEORGE
AU - JAY, GILBERT
T1 - The tat Gene of Human T-Lymphotropic virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice.
JO - Science
JF - Science
Y1 - 1987/09/11/
VL - 237
IS - 4820
M3 - Article
SP - 1324
EP - 1329
SN - 00368075
AB - Human T-lymphotropic virus type 1 (HTLV-1) is a suspected causative agent of adult T-cell leukemia. One of the viral genes encodes a protein (tat) that not only results in transactivation of viral gene expression but may also regulate the expression of certain cellular genes that are important for cell growth. Transgenic mice that expressed the authentic tat protein under the control of the HTLV-1 long terminal-repeat were generated, and cell types that are permissive for the viral promoter and the effects ofthe tat gene on these cells were studied. Three of eight founder mice with high levels of expression of the transgene in muscle were bred and then analyzed. All developed soft tissue tumors at multiple sites between 13 to 17 weeks of age. This phenotype was transmitted to nine of nine offspring that inherited the tat gene and were available for analysis. The remanig five founders expressed the transgene in the thymus, as well as in muscle. This second group of mice all exhibited extensive thymic depletion and growth retardation; in all of these mice, death occurred between 3 to 6 weeks ofage before tumors became macroscopically visible. The tat gene under the control of the HTLV-1 regulatory region showed tissuespecific expression and the tat protein efficiently induced mesenchymal tumors. The data establish tat as an oncogenic protein and HTLV-1 as a transforming virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519588; NERENBERG, MICHAEL 1 HINRICHS, STEVEN H. 1 REYNOLDS, R. KAY 1 KHOURY, GEORGE 1 JAY, GILBERT 1; Affiliation: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1324; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MUSTOE, THOMAS A.
AU - PIERCE, GLENN F.
AU - THOMASON, ARLEN
AU - GRAMATES, PEGGY
AU - SPORN, MICHAEL B.
AU - DEUEL, THOMAS F.
T1 - Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β.
JO - Science
JF - Science
Y1 - 1987/09/11/
VL - 237
IS - 4820
M3 - Article
SP - 1333
EP - 1336
SN - 00368075
AB - The role of polypeptide growth factors in the processes ofinflammation and repair was investigated by analyzing the influence of transforming growth factor-β (TGF-β), applied directly to linear iniasions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-β on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production ofthe wound and application of TGF-β. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-β. TGF-β is thus a potent pharmacologic agent that can accelerate wound healing in rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519587; MUSTOE, THOMAS A. 1 PIERCE, GLENN F. 2 THOMASON, ARLEN 3 GRAMATES, PEGGY 1 SPORN, MICHAEL B. 4 DEUEL, THOMAS F. 5; Affiliation: 1: Department of Surgery, Washington University Medical Center, St. Louis, MO 63110 2: Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110 3: Amgen, Inc., Thousand Oaks, CA 91320 4: Laboratory for Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5: Departments of Medicine and Biological Chemistry, Washington University Medical Center, St. Louis, MO 63110; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1333; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HINRICHS, STEVEN H.
AU - NERENBERG, MICHAEL
AU - REYNOLDS, R. KAY
AU - KHOURY, GEORGE
AU - JAY, GILBERT
T1 - A Transgenic Mouse Model for Human Neurofibromatosis.
JO - Science
JF - Science
Y1 - 1987/09/11/
VL - 237
IS - 4820
M3 - Article
SP - 1340
EP - 1343
SN - 00368075
AB - Human T-lymphotropic virus type 1 (HTLV-1) has been associated with the neurologic disorder tropical spastic paraparesis and possibly with multiple sclerosis. The tat gene of HTLV-1 under control of its own long terminal repeat is capable of inducng tumors in transgenic mice. The morphologic and biologic properties of these tumors indicate their dose resemblance to human neurofibromatosis (von Reklinghausen's disease), the most common single gene disorder to affect the nervous system. The high spontaneous incidence ofthis disease, together with the diverse clinical and pathologic features associated with it, suggests that environmental factors may account for some of the observed cases. Multiple tumors developed simultaneously in the transgenic tat mice at approximately 3 months of age, and the phenotype was successfully passed through three generations. The tumors arise from the nerve sheaths of peripheral nerves and are composed of perineural cells and fibroblasts. Tumor cells from these mice adapt easily to propagation in culture and continue to express the tat protein in significant amounts. When transplanted into nude mice, these cultured cells efficiently induce tumors. Evidence of HIV-1 infection in patients with neural and other soft tissue tumors is needed in order to establish a link between infection by this human retrovirus and von Recklinghausen's disease and other nonlymphoid tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519577; HINRICHS, STEVEN H. 1 NERENBERG, MICHAEL 1 REYNOLDS, R. KAY 1 KHOURY, GEORGE 1 JAY, GILBERT 1; Affiliation: 1: Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892; Source Info: 9/11/1987, Vol. 237 Issue 4820, p1340; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rogan, Walter J.
AU - Gladen, Beth C.
AU - McKinney, James D.
AU - Carreras, Nancy
AU - Hardy, Pam
AU - Thullen, James
AU - Tingelstad, Jon
AU - Tully, Mary
T1 - Polychlorinated Biphenyls (PCBs) and Dichlorodiphelyl Dichloroethene (DDE) in Human Milk: Effects on Growth, Morbidity, and Duration of Lactation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/10//
VL - 77
IS - 10
M3 - Article
SP - 1294
EP - 1297
PB - American Public Health Association
SN - 00900036
AB - Abstract: We followed 858 children from birth to one year of age to determine whether the presence of polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in breast milk affected their growth or health. Neither chemical showed an adverse effect on weight or frequency of physician visits for various illnesses, although differences were seen between breast-fed and bottle-fed children, with bottle-fed children being heavier and having more frequent gastroenteritis and otitis media. Children of mothers with higher levels of DDE were breast-fed for markedly shorter times, but adjustments for possible confounders and biases did not change the findings. In absence of any apparent effect on the health of the children, we speculate that DDE may be interfering with the mother's ability to lactate possibly because of its estrogenic properties. (Am J Public Health 1987: 77:1294-1297.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCHLORINATED biphenyls
KW - DICHLOROETHYLENE
KW - BREAST milk
KW - GROWTH factors
KW - DISEASES
KW - LACTATION
KW - BREASTFEEDING (Humans)
KW - BOTTLE feeding
KW - ADIPOSE tissues
KW - CASE studies
N1 - Accession Number: 4949835; Rogan, Walter J. 1,2,3,4,5,6 Gladen, Beth C. 1,2,3,4,5,6 McKinney, James D. 1,2,3,4,5,6 Carreras, Nancy 1,2,3,4,5,6 Hardy, Pam 1,2,3,4,5,6 Thullen, James 1,2,3,4,5,6 Tingelstad, Jon 1,2,3,4,5,6 Tully, Mary 7; Affiliation: 1: Epidemiology and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC. 2: Statistics and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC. 3: Biomathematics Branches and the Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences. Research Triangle Park, NC. 4: Durham Women's Clinic, Durham, NC. 5: Department of Pediatrics, East Carolina University School of Medicine, Greenville, NC. 6: Department of Pediatrics, University of North Carolina School of Medicine Chapel Hill, NC. 7: Wake Area Health Education Center, Raleigh, NC; Source Info: Oct87, Vol. 77 Issue 10, p1294; Subject Term: POLYCHLORINATED biphenyls; Subject Term: DICHLOROETHYLENE; Subject Term: BREAST milk; Subject Term: GROWTH factors; Subject Term: DISEASES; Subject Term: LACTATION; Subject Term: BREASTFEEDING (Humans); Subject Term: BOTTLE feeding; Subject Term: ADIPOSE tissues; Subject Term: CASE studies; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Connor, Amy B.
AU - Burgio, Louis D.
AU - Butler, Frieda A.
T1 - AN OBSERVATIONAL ANALYSIS OF SELF-STIMULATORY BEHAVIOR OF OLDER ADULTS IN A NURSING HOME.
JO - Behavioral Residential Treatment
JF - Behavioral Residential Treatment
Y1 - 1987/10//
VL - 2
IS - 4
M3 - Article
SP - 189
EP - 197
PB - John Wiley & Sons, Inc.
SN - 08845581
AB - Self-stimulatory behavior is described as a class of stereotyped and repetitive behaviors. This behavior often warrants concern because it can interfere with the learning and maintenance of more appropriate functional behaviors. In the present study, several topographies of self-stimulation were generated and the behavior of three older adult nursing home patients was observed for six weeks. Self-stimulation was high rate in all three subjects, and the manifestation of the behavior was idiosyncratic. Potential etiological factors and implications for treatment were discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Behavioral Residential Treatment is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER people
KW - HUMAN behavior
KW - MEDICAL geography
KW - NURSING home patients
KW - IDIOSYNCRATIC drug reactions
KW - SCHIZOPHRENICS
N1 - Accession Number: 12212798; Connor, Amy B. 1 Burgio, Louis D. 1 Butler, Frieda A. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 and Howard University College of Nursing, Washigton, DC 20001; Source Info: Oct87, Vol. 2 Issue 4, p189; Subject Term: OLDER people; Subject Term: HUMAN behavior; Subject Term: MEDICAL geography; Subject Term: NURSING home patients; Subject Term: IDIOSYNCRATIC drug reactions; Subject Term: SCHIZOPHRENICS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Suske, Guntram
AU - Mengel, Thomas
AU - Cordingley, Mike
AU - Kadenbach, Bernhard
T1 - Molecular cloning and further characterization of cDNAs for rat nuclear-encoded cytochrome c oxidase summits VIc and VIII.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/10//10/1/87
VL - 168
IS - 1
M3 - Article
SP - 233
EP - 237
PB - Wiley-Blackwell
SN - 00142956
AB - A cDNA library was constructed from poly(A)-rich RNA of H35 rat hepatoma cells by insertion into &lambd;gt11. Screening with an antiserum to rat liver holocytochrome-c oxidase yielded fifteen different recombinant clones. Eight clones were identified using monospecific antisera to individual subunits of the rat fiver enzyme. The cDNA clones coding for subunits VIc and VIII were further characterized by DNA sequence analysis after subcloning in pUC8 and M13 rap9. The deduced amino acid sequences show 80% and 60% homology to the corresponding bovine heart subunits, respectively. From the nucleotide sequences we can conclude that subunit VIc is not synthesized as a larger precursor molecule like most other mitochondrial proteins. The size of the mRNAs coding for subunits VIc and VIII is about 450 nucleotides, as revealed by Northern blot analysis with RNAs from different tissues. The clones were further used as probes for Southern blotting. Restricted high-molecular-mass DNA showed a complex pattern of bands indicating multigene families for both subunits in the rat genome. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CIRCULAR DNA
KW - GENE libraries
KW - RECOMBINANT DNA
KW - HEPATOMA
KW - LIVER cells
KW - ANTI-antibodies
KW - AMINO acid sequence
N1 - Accession Number: 13860538; Suske, Guntram 1 Mengel, Thomas 1 Cordingley, Mike 2 Kadenbach, Bernhard 1; Affiliation: 1: Biochemie, Fachbereich Chemie der Philipps-Universität, Marburg 2: National Institutes of Health, Bethesda, Maryland; Source Info: 10/1/87, Vol. 168 Issue 1, p233; Subject Term: CIRCULAR DNA; Subject Term: GENE libraries; Subject Term: RECOMBINANT DNA; Subject Term: HEPATOMA; Subject Term: LIVER cells; Subject Term: ANTI-antibodies; Subject Term: AMINO acid sequence; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Powers, Douglas C.
AU - Sears, Stephen D.
T1 - Influenza, pneumonia, tetanus: How effective is vaccination?
JO - Geriatrics
JF - Geriatrics
Y1 - 1987/10//
VL - 42
IS - 10
M3 - Article
SP - 81
EP - 90
SN - 0016867X
N1 - Accession Number: 15868571; Powers, Douglas C. 1,2; Sears, Stephen D. 3,4; Source Information: Oct1987, Vol. 42 Issue 10, p81; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3146
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Stupak, Ronald J.
AU - Moore, Jerry E.
T1 - THE PRACTICE OF MANAGING ORGANIZATION DEVELOPMENT IN PUBLIC SECTOR ORGANIZATIONS; REASSESSMENTS, REALITIES, AND REWARDS.
JO - International Journal of Public Administration
JF - International Journal of Public Administration
Y1 - 1987/10//
VL - 10
IS - 3
M3 - Article
SP - 131
EP - 153
SN - 01900692
AB - This article examines some of the questions that have been raised by many scholars, consultants, and managers regarding the relevance of organization development (OD) to public sector organizations. Some of the questions addressed include: To what extent is OD- as a strategy for planning and implementing change--relevant to public sector management? What are the salient differences between public and private sector organizations that can affect the practice and effectiveness of OD? What strategies can be used to accommodate these differences? How can the practice of OD be effectively managed in public sector organizations? What kinds of modifications in the field of OD are necessary to enhance its future relevance to public sector organizations? What are the possible impacts of the Reagan cutback management philosophy for OD in the public sector? After exhaustive analysis, it becomes clear that the public manager who develops a fair understanding of the values, assumptions, and technologies of OD, and the OD consultant who demonstrates a clear understanding of the unique nature of the public sector environment, can successfully manage OD in public organizations if they can set modest goals, accept unexpected setbacks, and be satisfied with tackling manageable issues as opposed to attempting to change the entire system at a fundamental level. A central theme of American public administration is that government can and should be run like a business enterprise. Since the earliest days of the American political system, reform efforts have been guided by an enduring belief in what has been termed the "business analogy." That is, the nature, problems, and general functions of public and corporate management are viewed as being essentially analogous. Therefore, the assumption is made that the relatively well developed body of ideas and practices of corporate management can and should be applied to the management of government. Public management can and should be more business like. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Public Administration is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANIZATIONAL change
KW - PUBLIC sector
KW - ASSESSMENT centers (Personnel management procedure)
KW - MANAGEMENT science
KW - PUBLIC administration
KW - INDUSTRIAL management
N1 - Accession Number: 11951532; Stupak, Ronald J. 1; Moore, Jerry E. 2; Affiliations: 1: Director and Professor Washington Public Affairs Center School of Public Administration University of Southern California.; 2: Senior Management Analyst Workforce Effectiveness Staff Division of Management Policy National Institutes of Health.; Issue Info: 1987, Vol. 10 Issue 3, p131; Thesaurus Term: ORGANIZATIONAL change; Thesaurus Term: PUBLIC sector; Thesaurus Term: ASSESSMENT centers (Personnel management procedure); Thesaurus Term: MANAGEMENT science; Thesaurus Term: PUBLIC administration; Thesaurus Term: INDUSTRIAL management; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rogers, George
AU - Martinet, Nadine
AU - Steinert, Peter
AU - Wynn, Peter
AU - Roop, Dennis
AU - Kilkenny, Anne
AU - Morgan, David
AU - Yuspa, Stuart H.
T1 - Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/10//
VL - 89
IS - 4
M3 - Article
SP - 369
EP - 379
SN - 0022202X
AB - Techniques are described for the isolation and cultivation of functionally intact mouse hair follicles. Follicles were isolated by collagenase digestion of dermis from 5-day-old mice and purified by differential centrifugation and filtration. Purified follicles were cultured in a Type 1 collagen matrix using Medium 199 and 8% fetal calf serum as the basic nutrient. Viability of follicles was maintained in culture Since the cultures incorporated thymidine into DNA and methionine into proteins for at least 7 days. Further- more, follicles isolated from the collagen matrix after 7 days could reattach to a plastic culture substrate or be further cultivated in a fresh collagen matrix. Functional integrity of cultured follicles was maintained since some follicle-specific cytoskeletal proteins were synthesized in vitro, and follicles isolated from the collagen matrix after 7 days formed a haired skin when recombined with dermal fibroblasts and grafted to a skin site on nude mice. Only a minority of follicles appeared to produce a mature hair shaft in vitro by morphologic criteria, however, and synthesis of the total complement of hair proteins was not observed. Cholera toxin was a strong mitogen for cultured follicles, whereas epidermal growth factor was slightly mitogenic. Epidermal growth factor stimulated the release of a Type 1 collagenase by follicle cells, however. This model system provides an opportunity for the systematic analysis of factors required for the induction of hair growth and the underlying physiology of hair follicle development. This model should also be useful for studying the role of the hair follicle in skin carcinogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAIR
KW - COLLAGEN
KW - THYMIDINE
KW - DNA
KW - DERMIS
KW - FIBROBLASTS
N1 - Accession Number: 12471760; Rogers, George 1 Martinet, Nadine 2 Steinert, Peter 3 Wynn, Peter 4 Roop, Dennis 5 Kilkenny, Anne 5 Morgan, David 5 Yuspa, Stuart H. 5; Affiliation: 1: Department of Biochemistry, University of Adelaide, Adelaide, South Australia. 2: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Cancer Institute, Bethesda, Maryland, U.S.A. 3: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A. 4: Ian Clunies Ross Animal Research Laboratories Division of Animal Production, CSIRO, Blacktown, N. S. W., Australia. 5: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Oct87, Vol. 89 Issue 4, p369; Subject Term: HAIR; Subject Term: COLLAGEN; Subject Term: THYMIDINE; Subject Term: DNA; Subject Term: DERMIS; Subject Term: FIBROBLASTS; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1523-1747.ep12471760
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06441-020
AN - 2006-06441-020
AU - Crawley, Jacqueline N.
T1 - GABAergic Antidepressants.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1987/10//
VL - 32
IS - 10
SP - 876
EP - 877
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06441-020. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Crawley, Jacqueline N.; Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Affective Disorders; Emotional States; Gamma Aminobutyric Acid. Minor Descriptor: Psychopharmacology. Classification: Affective Disorders (3211); Clinical Psychopharmacology (3340). Population: Human (10). Reviewed Item: Bartholini, G. (Ed); Lloyd, K. G. (Ed); Morselli, P. L. (Ed). GABA and Mood Disorders: Experimental and Clinical Research=New York: Raven Press, 1986. 222 pp. $29.50; 1986. Page Count: 2. Issue Publication Date: Oct, 1987.
AB - Reviews the book, GABA and Mood Disorders: Experimental and Clinical Research edited by G. Bartholini, K. G. Lloyd, and P. L. Morselli (1986). The volume begins with the rationale for studying gamma aminobutyric acid (GABA) with respect to human depression, including a review of the monoamine transmitters classically linked to depression, the structure of the GABA-benzodiazepine-chloride channel receptor complex, and the subtypes of highand low-affinity GABA receptors. Although this volume is obviously a product of a pharmaceutical company committed to promoting its new line of drugs, it contains a fascinating story of how a new drug comes into being. It is refreshing to read an account of the way psychopharmacological agents are developed today. This volume gives the reader the reassuring impression that new drugs will be more specific, with fewer deleterious side effects, and more efficacious against mental illnesses in future generations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mood disorders
KW - clinical research
KW - experimental research
KW - antidepressants
KW - gamma aminobutyric acid antagonists
KW - 1987
KW - Affective Disorders
KW - Emotional States
KW - Gamma Aminobutyric Acid
KW - Psychopharmacology
KW - 1987
U2 - Bartholini, G. (Ed); Lloyd, K. G. (Ed); Morselli, P. L. (Ed). (1986); GABA and Mood Disorders: Experimental and Clinical Research; New York: Raven Press, 1986. 222 pp. $29.50; 0-88167-129-0.
DO - 10.1037/026430
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lanza, Elaine
AU - Jones, D. Yvonne
AU - Block, Gladys
AU - Kessler, Larry
T1 - Dietary fiber intake in the US population.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/11//
VL - 46
IS - 5
M3 - Article
SP - 790
EP - 797
SN - 00029165
AB - Twenty-four hour recall data from adults interviewed in the Second National Health and Nutrition Examination Survey, NHANES II, were used as the basis to estimate total dietary fiber intake in the United States. Food fiber values were calculated for the 2500 foods in NHANES II in two ways: 1) using fiber values compiled from the literature by NCI and 2) values based on the Southgate methodology. Mean dietary fiber intake in the US adult population (> 19 y of age) is 11.1 g/d using the first set of values and 13.3 g/d according to Southgate values. On a per 1000 kcal basis, women consume more dietary fiber (6.5 g/1000 kcal) than men (5.5 g/1000 kcal) at every age. Fiber intake by geographic region, age, race, and sex is discussed. Our study indicates that dietary fiber intake in the United States is considerably lower than that previously reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Fiber in human nutrition
KW - Age groups
KW - Body mass index
KW - Physical fitness
KW - Dietary fiber
KW - nutrient intakes
N1 - Accession Number: 91710887; Lanza, Elaine 1; Jones, D. Yvonne 1; Block, Gladys 1; Kessler, Larry 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Nov1987, Vol. 46 Issue 5, p790; Thesaurus Term: Nutrition; Subject Term: Fiber in human nutrition; Subject Term: Age groups; Subject Term: Body mass index; Subject Term: Physical fitness; Author-Supplied Keyword: Dietary fiber; Author-Supplied Keyword: nutrient intakes; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Milton, Roy C.
AU - Reddy, Vinodini
AU - Naidu, A. N.
T1 - Mild vitamin A deficiency and childhood morbidity--an Indian experience.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/11//
VL - 46
IS - 5
M3 - Article
SP - 827
EP - 829
SN - 00029165
AB - Over 1500 preschool urban Indian children were followed weekly for morbidity from 12 to 18 mo. Examination for mild xerophthalmia (Bitot's spots and night blindness) was done initially and at 6 and 12 mo. Children with mild xerophthalmia at the start of a 6-mo interval developed respiratory disease in the interval twice as often as children with normal eyes at the start of the interval. No association was found between mild xerophthalmia and incidence of diarrhea. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Xerophthalmia
KW - Respiratory diseases
KW - Vitamin A deficiency
KW - Diarrhea
KW - Summer diseases
KW - School children -- India
KW - diarrhea
KW - incidence
KW - respiratory disease
KW - vitamin A deficiency
N1 - Accession Number: 91710892; Milton, Roy C. 1; Reddy, Vinodini 2; Naidu, A. N. 2; Affiliations: 1: National Eye Institute, Bethesda, MD; 2: National Institute of Nutrition, Hyderabad, India; Issue Info: Nov1987, Vol. 46 Issue 5, p827; Subject Term: Xerophthalmia; Subject Term: Respiratory diseases; Subject Term: Vitamin A deficiency; Subject Term: Diarrhea; Subject Term: Summer diseases; Subject Term: School children -- India; Author-Supplied Keyword: diarrhea; Author-Supplied Keyword: incidence; Author-Supplied Keyword: respiratory disease; Author-Supplied Keyword: vitamin A deficiency; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Digregorio, Gayle
AU - Suomi, Stephen J.
AU - Eisele, Carole E.
AU - Chapman, Sharon A.
T1 - Reactions of Nuclear-Family--Reared Rhesus Macaques to the Births of Younger Siblings.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1987/11//
VL - 13
IS - 3
M3 - Article
SP - 231
EP - 253
SN - 02752565
AB - A group of juvenile rhesus macaques (Macaca mulatta) living in a nuclear-family laboratory environment was studied to determine their responses to the births of siblings. The frequencies of interactions with family members (mothers, fathers, and new siblings) and nonfamily (peers, unrelated infants, and unrelated adults) were studied over both the year preceding and the year following sibling birth. The frequencies of specific behaviors in each of those interactions and the frequencies of interactions in each area of the nuclear-family unit (home cage, play area, or other families' cage) were also examined. After new siblings arrived, several measures of interactions with mothers, fathers, and new siblings increased significantly; by contrast inter-actions with peers decreased substantially over the post-birth year. Although the frequency of interactions in home cages remained stable over the 2-year period, interactions outside of the subjects' home cages decreased significantly after siblings were born. An additional subject group whose mothers became pregnant but failed to deliver viable offspring showed no significant changes in total levels of interactions with peers; they did, however, exhibit increases in some interactions with unrelated infants and adults. Female juveniles interacted with new siblings siginificantly more often than did males when siblings were less than 6 months old, but as siblings grew older (6-12 months), females' levels of interaction with them felt to a level equal to that of males. In the nuclear-family social structure, the birth of a sibling resulted in an increased emphasis on family interactions at the expense of peer interactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHESUS monkey
KW - BROTHERS & sisters
KW - NUCLEAR families
KW - ANIMAL young
KW - PREGNANCY in animals
KW - PEERS
KW - kinship
KW - peer interactions .
KW - Rhesus macaque
KW - siblings
KW - social behavior
N1 - Accession Number: 12363629; Digregorio, Gayle 1 Suomi, Stephen J. 1 Eisele, Carole E. 1 Chapman, Sharon A. 1; Affiliation: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human, Development, Bethesda, Maryland.; Source Info: 1987, Vol. 13 Issue 3, p231; Subject Term: RHESUS monkey; Subject Term: BROTHERS & sisters; Subject Term: NUCLEAR families; Subject Term: ANIMAL young; Subject Term: PREGNANCY in animals; Subject Term: PEERS; Author-Supplied Keyword: kinship; Author-Supplied Keyword: peer interactions .; Author-Supplied Keyword: Rhesus macaque; Author-Supplied Keyword: siblings; Author-Supplied Keyword: social behavior; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ockene, Judith K.
AU - Pechacek, Terry F.
AU - Vogt, Thomas
AU - Svendsen, Ken
T1 - Does Switching from Cigarettes to Pipes Reduce Tobacco Smoke Exposure?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/11//
VL - 77
IS - 11
M3 - Article
SP - 1412
EP - 1416
PB - American Public Health Association
SN - 00900036
AB - (For the MRFIT Research Group) Abstract: Cigarette smoking histories, reported depth of inhalation, number of pipe and cigars (PC) smoked, serum thiocyanate (SCN) and expired air carbon monoxide (CO) levels were examined in PC male smokers enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). Serum SCN levels for all PC smokers were higher than for non-smokers and lower than for current cigarette smokers. Levels were related lo the amount of product smoke. Prior cigarette smokers had higher SCN levels when compared to PC users who had never smoked cigarettes, smoked a larger number of tobacco, products pet' day, and reported inhaling into the chest more often. Prospective data on baseline cigarette smokers demonstrated that smokers who stopped all tobacco products had a greater drop in SCN and CO than those who switched to PC. The findings strongly suggest that cessation of all tobacco products is the best strategy for decreasing exposure to tobacco smoke Am Public Health 1987; 77: 1412-1416.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CIGARETTE smokers
KW - THIOCYANATES
KW - CARBON monoxide
KW - SMOKING
KW - TOBACCO products
KW - TOBACCO
KW - ANTISMOKING movement
KW - TOBACCO industry
KW - CLINICAL trials
N1 - Accession Number: 4951907; Ockene, Judith K. 1 Pechacek, Terry F. 2 Vogt, Thomas 3 Svendsen, Ken 4; Affiliation: 1: Division of Preventive Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2: Director, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda 3: Center for Health Services, Portland, OR 97215 4: Coordinating Centers for Biometric Research, University of Minnesota, Minneapolis; Source Info: Nov87, Vol. 77 Issue 11, p1412; Subject Term: CIGARETTE smokers; Subject Term: THIOCYANATES; Subject Term: CARBON monoxide; Subject Term: SMOKING; Subject Term: TOBACCO products; Subject Term: TOBACCO; Subject Term: ANTISMOKING movement; Subject Term: TOBACCO industry; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - James, S. P.
AU - Graeff, A.S.
T1 - Effect of IL-2 on immunoregulatory function of intestinal lamina propria T cells in normal non-human primates.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/11//
VL - 70
IS - 2
M3 - Article
SP - 394
EP - 402
PB - Wiley-Blackwell
SN - 00099104
AB - The role of T cell activation on the immunoregulatory function of lymphocytes in the lamina propria of the normal intestine was investigated. Lymphocytes were isolated from different sites in non-human primates, and their cell surface phenotypes, response to exogenous IL-2, and immunoregulatory function in pokeweed mitogen stimulated cultures were determined. The proportions of Leu-3+ (CD4) and Leu-2+ (CD8) lymphocytes in isolated lamina propria cells were similar to peripheral blood and spleen, but the proportion of Leu-3+ cells was significantly higher in mesenteric lymph node lymphocytes. The proportion of IL-2 receptor positive cells was significantly higher in lamina propria compared with peripheral blood, spleen and mesenteric lymph nodes. Increased IL-2 receptor expression was found on both Leu-3+ and Leu-2+ lamina propria T cells. In addition, although lamina propria T cells had a lower proliferative response to Con A, they had a significantly higher response when cultured with recombinant IL-2, indicating that they have increased expression of functional IL-2 receptors. The helper function of lamina propria T cells for pokeweed mitogen stimulated immunoglobulin synthesis was enhanced by recombinant IL-2. Although Leu-2+ lymphocytes in the lamina propria had increased lL-2 receptor expression, suppressor function of lamina propria T cells was similar to that of spleen cells, and was not enhanced by addition of exogenous IL-2. Thus. T cells in the lamina propria have increased expression of functional IL-2 receptors, and recombinant IL-2 enhances the helper, but not the suppressor function of lamina propria T cells for immunoglobulin synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - CELLS
KW - T cells
KW - LEUCOCYTES
KW - LYMPHOID tissue
KW - LYMPH nodes
KW - lamina propria lymphocytes interleukin 2 primate lymphocytes intestinal lymphocytes
N1 - Accession Number: 15993328; James, S. P. 1 Graeff, A.S. 1; Affiliation: 1: Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Nov1987, Vol. 70 Issue 2, p394; Subject Term: LYMPHOCYTES; Subject Term: CELLS; Subject Term: T cells; Subject Term: LEUCOCYTES; Subject Term: LYMPHOID tissue; Subject Term: LYMPH nodes; Author-Supplied Keyword: lamina propria lymphocytes interleukin 2 primate lymphocytes intestinal lymphocytes; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chopra, R. K.
AU - Nagel, J. E.
AU - Chrest, F. J.
AU - Adler, W. H.
T1 - Impaired phorbol ester and calcium ionophore induced proliferation of T cells from old humans.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1987/11//
VL - 70
IS - 2
M3 - Article
SP - 456
EP - 462
PB - Wiley-Blackwell
SN - 00099104
AB - Current models of T cell activation implicate increases in intracellular free Ca2+ concentration and activation of the Ca2+ and phospholipid dependent enzyme protein kinase C (PKC) as important early events leading to interieukin 2 (IL-2) production, interleukin 2 receptor (IL-2R) expression, and subsequent cell proliferation. The present study examined the age-related defect in T cell proliferation to determine if the signals that activate PKC and increase intracytosolic free Ca2+ concentration might be defective. Using phorbol myristate acetate (PMA), which directly activates PKC, and Ca2+ ionophore A23187, which increases intracellular cytoplasmic free Ca2+ concentration, the induction of IL-2 secretion, IL-2R expression and cell proliferation were studied. The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation. Exogenous purified human IL-2 did not fully correct the low proliferative responses of T cells from old donors, however, did markedly boost the response. While it appears that the inability of T cells to express IL-2 Rand respond to IL- 2, along with a lower endogenous IL-2 production are limiting factors in cell proliferation, the inability of PMA and A23187 to correct this defect suggests that the early phases of signal transduction per se are probably not a primary cause of the immunodeficiency seen in ageing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANIC compounds
KW - LYMPHOCYTES
KW - CELL division (Biology)
KW - CELL proliferation
KW - CELLULAR growth
KW - PHORBOL esters
KW - Ca-ionophore phorbol myristale acetate interleukin 2 interleukin 2 receptor
N1 - Accession Number: 15993375; Chopra, R. K. 1 Nagel, J. E. 1 Chrest, F. J. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Ageing, National Institutes of Health, Baltimore, Maryland.; Source Info: Nov1987, Vol. 70 Issue 2, p456; Subject Term: ORGANIC compounds; Subject Term: LYMPHOCYTES; Subject Term: CELL division (Biology); Subject Term: CELL proliferation; Subject Term: CELLULAR growth; Subject Term: PHORBOL esters; Author-Supplied Keyword: Ca-ionophore phorbol myristale acetate interleukin 2 interleukin 2 receptor; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gaither, T. A.
AU - Vargas, I.
AU - Inada, S.
AU - Frank, M. M.
T1 - The complement fragment C3d facilitates phagocytosis by monocytes.
JO - Immunology
JF - Immunology
Y1 - 1987/11//
VL - 62
IS - 3
M3 - Article
SP - 405
EP - 411
PB - Wiley-Blackwell
SN - 00192805
AB - Two receptors for fragments of C3 are described for human monocytes: CR1 and CR3, which bind C3b and iC3b, respectively. Recently a leucocyte receptor that binds C3dg has also been described, designated CR4. We previously reported that IgM-sensitized sheep erythrocytes that are heavily coated with C3d (EAC3d) can bind to human monocytes that have been cultured in fetal calf serum (FCS). Here we determine whether such binding of C3d-coated targets can lead to phagocytosis, and identify the specific monocyte receptor involved in C3d binding. We confirm that EAC3d bearing greater than 10,000 C3d/cell bind to FCS-cultured monocytes. Furthermore, using non-cultured monocytes, we demonstrate that C3d enhances rosette formation of IgG-coated E and, like C3b and iC3b, C3d augments IgG Fc receptor-mediated phagocytosis. Less than 100 C3d/cell are capable of enhancing phagocytosis, whereas 10,000 or more C3d/cell are required for rosette formation with cultured cells. These results indicate that the C3d-binding receptor is present on peripheral blood monocytes but has poor affinity for target particles coated only with C3d. Anti-CR2 monoclonal antibodies, which recognize the C3d receptor of lymphocytes, do not block EAC3d rosette formation with monocytes. In contrast anti-Mol, a monoclonal antibody against CR3, inhibits EAC3d rosettes by approximately 42%. Anti-CR1 increases this effect, but complete inhibition is not achieved. Ethylenediamine tetraacetate also markedly reduces EAC3d rosetting, reducing the numbers to less than 5%. Thus, the C3d-binding receptor on monocytes, unlike CR4, is metal dependent. Together these data indicate that CR3 is predominantly responsible for C3d binding to monocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHAGOCYTOSIS
KW - MONOCYTES
KW - LEUCOCYTES
KW - ERYTHROCYTES
KW - ACETATES
KW - ETHYLENEDIAMINE
N1 - Accession Number: 14007982; Gaither, T. A. 1 Vargas, I. 1 Inada, S. 2 Frank, M. M. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases 2: Fugita-Gakuen University, Nagoya, Japan; Source Info: Nov87, Vol. 62 Issue 3, p405; Subject Term: PHAGOCYTOSIS; Subject Term: MONOCYTES; Subject Term: LEUCOCYTES; Subject Term: ERYTHROCYTES; Subject Term: ACETATES; Subject Term: ETHYLENEDIAMINE; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104761988
T1 - Regional cerebral palmitate incorporation following transient bilateral carotid occlusion in awake gerbils.
AU - Tone, O
AU - Miller, J C
AU - Bell, J M
AU - Rapoport, S I
Y1 - 1987/11//1987 Nov-Dec
N1 - Accession Number: 104761988. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266.
KW - Cerebral Ischemia -- Metabolism
KW - Rodents -- Metabolism
KW - Hippocampus -- Metabolism
KW - Fatty Acids -- Metabolism
KW - Animals
KW - Cerebral Ischemia -- Etiology
KW - Radioisotopes -- Diagnostic Use
KW - Carotid Arteries -- Physiology
KW - Cell Physiology
KW - Cerebrovascular Circulation
KW - Consciousness
KW - Immobilization
KW - Hippocampus -- Pathology
KW - Lipid Metabolism, Inborn Errors
KW - Male
KW - Time Factors
SP - 1120
EP - 1127
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 18
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - [14C]Palmitate was injected intravenously in awake gerbils at various times after 5 minutes of bilateral carotid artery occlusion or a sham operation. Regional rates of incorporation of plasma palmitate into the hippocampus and other regions of the anterior circulation were determined relative to the mean rate of incorporation into regions of the posterior circulation using quantitative autoradiography and a ratio method of analysis. One day after bilateral carotid occlusion, relative palmitate incorporation was elevated significantly by 16% in the CA4 pyramidal cell layer and by 20% in the dentate gyrus of the hippocampus compared with sham-operated gerbils. At 3 days, significant elevations of this magnitude were found in the CA3 and CA4 cell layers, whereas relative incorporation was reduced by 26% in the CA1 pyramidal cell layer. At 7 days, the only significant difference from control was a 15% elevated incorporation in the CA3 pyramidal cell layer. Histologic examination indicated substantial cell death in the CA1 pyramidal layer at 3 days, with extensive glial reaction and phagocytic invasion at 7 days. Our results suggest that the turnover of palmitate-containing lipids is reduced in the CA1 layer of the gerbil hippocampus but that lipid synthesis is stimulated in hippocampal regions (CA3, CA4, dentate gyrus) affected by but recovering from transient bilateral carotid occlusion.
SN - 0039-2499
AD - Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
U2 - PMID: 3686587.
DO - 10.1161/01.STR.18.6.1120
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kimura, Teruyuki
AU - Owens, Ida S.
T1 - Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1987/11/02/
VL - 168
IS - 3
M3 - Article
SP - 515
EP - 521
PB - Wiley-Blackwell
SN - 00142956
AB - A cDNA clone (UDPGTm-1) encoding a mouse UDP glucuronosyltransferase (transferase) was isolated from pBR322 and λgt11 libraries by hybridization to a rat transferase clone. This eDNA is 1860 bp long and 65-87% similar at both the nucleotide and the deduced amino acid sequence levels to three different rat transferase clones [Mackenzie, P. I. et al. (1984) J. Biol. Chem. 259, 12153-12160; Mackenzie, P. I. (1986) J. Biol. Chem. 261, 6119-6125]. UDPGTm-1, like the rat transferase clones already described, contains an open reading frame of 1590 bp encoding 530 amino acids (unmodified Mr = 60856), an N-terminus membrane-insertion signal sequence, a carboxy-terminus hydrophobic putative membrane-spanning region, and potential asparagine-linked glycosylation sites (residues 316 and 483). The eDNA contains two poly(A) addition consensus sequences at positions 1695-1837. UDPGTm-1 is complementary to a 2200-base mRNA and also cross-hybridizes to a 2000-base mRNA species due to sequence homology in the 5' region of the clone. Both the 2200-base and the 2000-base mRNA are induced approximately 2.5-fold by the hypolipidemic agent clofibrate, and also by phenobarbital and benzo[a]pyrene. A new and more potent hypolipidemic agent, perfluorooctanoic acid, is also shown to induce both mRNA species. Each of these compounds induces bilirubin transferase activity in a manner parallel to the effects on mRNA, i. e. perfluorooctanoic acid being the most effective, followed by phenobarbital, beazo[a]pyrene, and clofibrate. Southern blot hybridization of UDPGTm-1 to mouse genomic DNA showed sequence homology to a total DNA size of 40-50 kb. These data indicate that UDPGTm-1, is a member of a new subfamily of transferases in mouse with patterns of regulation of their mRNAs similar to that seen for bilirubin transferase activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCURONOSYLTRANSFERASE
KW - GLYCOSYLTRANSFERASES
KW - DNA
KW - AMINO acid sequence
KW - MESSENGER RNA
KW - HOMOLOGY (Biology)
N1 - Accession Number: 13813498; Kimura, Teruyuki 1 Owens, Ida S. 1; Affiliation: 1: Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; Source Info: 11/2/87, Vol. 168 Issue 3, p515; Subject Term: GLUCURONOSYLTRANSFERASE; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: DNA; Subject Term: AMINO acid sequence; Subject Term: MESSENGER RNA; Subject Term: HOMOLOGY (Biology); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - IWAMOTO, YUKIHIDE
AU - ROBEY, FRANK A.
AU - GRAF, JEANNETTE
AU - SASAKI, MAKOTO
AU - KLEINMAN, HYNDA K.
AU - YAMADA, YOSHIHIKO
AU - MARTIN, GEORGE R.
T1 - YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimenal Metastasis Formation.
JO - Science
JF - Science
Y1 - 1987/11/20/
VL - 238
IS - 4830
M3 - Article
SP - 1132
EP - 1134
SN - 00368075
AB - The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachent and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence oflaminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477684; IWAMOTO, YUKIHIDE 1 ROBEY, FRANK A. 2 GRAF, JEANNETTE 1 SASAKI, MAKOTO 1 KLEINMAN, HYNDA K. 1 YAMADA, YOSHIHIKO 1 MARTIN, GEORGE R. 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, National Institutes of Health, Bethesda, MD 20892 2: Bureau of Biologics, Food and Drug Administration, Bethesda, MD 20892; Source Info: 11/20/1987, Vol. 238 Issue 4830, p1132; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KEHRL, JOHN H.
AU - ALVAREZ-MON, MELCHOR
AU - DELSING, GITA A.
AU - FAUCI, ANTHONY S.
T1 - Lymphotoxin Is an Important T Cell-Derived Growth Factor for Human B Cells.
JO - Science
JF - Science
Y1 - 1987/11/20/
VL - 238
IS - 4830
M3 - Article
SP - 1144
EP - 1146
SN - 00368075
AB - Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin hanced the proliferation of activated B cells and augented B cell proliferation and inmunogloblin secretion induced by interleukin-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477688; KEHRL, JOHN H. 1 ALVAREZ-MON, MELCHOR 1 DELSING, GITA A. 1 FAUCI, ANTHONY S. 1; Affiliation: 1: Laboratory of Immunoregulation, National Institute of Allergy and Infetious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 11/20/1987, Vol. 238 Issue 4830, p1144; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mulhern, Sally A.
AU - Raveche, Elizabeth S.
AU - Smith, Howard R.
AU - Lai, Renu B.
T1 - Dietary copper deficiency and autoimmunity in the NZB mouse.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/12//
VL - 46
IS - 6
M3 - Article
SP - 1035
EP - 1039
SN - 00029165
AB - NZB mice were exposed from birth to a diet either adequate or deficient in copper. By age 6 wk the mice exposed to the copper-deficient diet showed symptoms characteristic of copper deficiency (anemia, hypoceruloplasminemia, and achromatrichia). The splenic lymphocytes from the copper-deficient group had reduced numbers of cells expressing the following surface markers: Ly-5, Ly-1, B-220, and sIg. Less than 10% of the splenic lymphocytes in this group were cycling, as determined by flow cytometry analysis. The spontaneous 96-h anti-ss-DNA levels in the copper-deficient group were lower than those in the control group. The exogenous colony-forming units (CFUs) were significantly enhanced in the copper-deficient mice. The decreased splenic lymphoid populations, decreased anti-ss-DNA titers, and increased exogenous CFUs in the copper-deficient mice appear to be due to an increase in erythropoiesis at the expense of lymphopoiesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Cytometry
KW - Autoimmunity
KW - Autoantibodies
KW - Lymphoid tissue
KW - copper deficiency
KW - immunology
KW - nutrition
N1 - Accession Number: 91710908; Mulhern, Sally A. 1; Raveche, Elizabeth S. 2; Smith, Howard R. 3; Lai, Renu B. 4; Affiliations: 1: Food and Drug Administration, Washington, DC; 2: Albany Medical College of Union University, Albany, NY; 3: Veterans Administration Hospital, Boston, MA; 4: National Institutes of Health, Bethesda, MD; Issue Info: Dec1987, Vol. 46 Issue 6, p1035; Thesaurus Term: Dietary supplements; Thesaurus Term: Cytometry; Subject Term: Autoimmunity; Subject Term: Autoantibodies; Subject Term: Lymphoid tissue; Author-Supplied Keyword: copper deficiency; Author-Supplied Keyword: immunology; Author-Supplied Keyword: nutrition; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Malloy, Michael H.
AU - Hartford, Robert B.
AU - Kleinman, Joel C.
T1 - Trends in Mortality Caused by Respiratory Distress Syndrome in the United States, 1969-83.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/12//
VL - 77
IS - 12
M3 - Article
SP - 1511
EP - 1514
PB - American Public Health Association
SN - 00900036
AB - Abstract: Using United States vital statistical data we examined trends in infant deaths from Respiratory Distress Syndrome/Hyaline Membrane Disease (RDS/HMD) for 1969 to 1983, by race and age at death, In order to improve comparability of diagnosis across two revisions of the International Classification of Diseases, deaths from RDS/HMD were ascertained using both underlying and associated causes of death, These data document a 2 per ¢ per year increase in infant mortality attributed to RDS/HMD for all races during interval I (1969-73) tallowed by 9 per ¢ per year decreases during intervals II (1974-78) and III (1979-83), However. there was a marked difference between Whites and Blacks ia these trends. In the White population, RDS/HMD infant mortality increased by 22 per ¢ per year irt interval I but then decreased by 10.5 percent per year in interval II and 8.9 per ¢ per year in interval III. Among Blacks, on the other hand, the initial increase in RDS/HMD mortality was steeper (5.2 per ¢ per year) and the subsequent decreases were less (6.3 per ¢ per year and 8.0 per ¢ pet' year). As a result, the Black-White ratio in infant mortality attributed to RDS/HMD increased from 1.32 in 1969-73, to 1.59 in 1974-78 and to 1.72 in 1979-83. The proportion of RDS/HMD deaths that occurred in the postneonatal period increased from I. I percent in interval 1 to 3.6 per ¢ in interval II to 5.0 per ¢ in interval III. During the last interval, the decline in RDS/HMD mortality accounted for 30 per ¢ of the decline in overall infant mortality for both Whites and Blacks. (Am J Public Health 1987: 77:1511-1514.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANTS -- Death
KW - DEATH -- Causes
KW - PEDIATRIC respiratory diseases
KW - RESPIRATORY distress syndrome
KW - PULMONARY manifestations of general diseases
KW - HYALINE membrane disease
KW - MORTALITY -- Statistics
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 4949568; Malloy, Michael H. 1 Hartford, Robert B. 2 Kleinman, Joel C. 3; Affiliation: 1: Prevention Research Program, National Institute of Child Health and Human Development, Landow Building, Room 8A06, 7910 Woodmount Avenue, Bethesda, MD 20892 2: Deputy Chief, International Statistics Staff, Office of Planning and Extramural Programs, National Center for Health Statistics 3: Director, Division of Analysis, Office of Analysis and Epidemiology Program, NCHS; Source Info: Dec1987, Vol. 77 Issue 12, p1511; Subject Term: INFANTS -- Death; Subject Term: DEATH -- Causes; Subject Term: PEDIATRIC respiratory diseases; Subject Term: RESPIRATORY distress syndrome; Subject Term: PULMONARY manifestations of general diseases; Subject Term: HYALINE membrane disease; Subject Term: MORTALITY -- Statistics; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McWhorter, William P.
AU - Mayer, William J.
T1 - Black/White Differences in Type of Initial Breast Cancer Treatment and Implications for Survival.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/12//
VL - 77
IS - 12
M3 - Article
SP - 1515
EP - 1517
PB - American Public Health Association
SN - 00900036
AB - Abstract: The relation between race, type of initial treatment, and survival with breast cancer were investigated using 36,905 cases reported to nine registries in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute in the years 1978-82 and followed for survival through 1984. Using the crude treatment categories of surgical/nonsurgical/untreated, Blacks were found lo have received less aggressive therapy. They were more likely than Whites to be treated nonsurgicalty (OR = 1.4: 95% CI = 1.2-1.7) or have no cancer-directed therapy (OR = 1.7; 95% CI = 1.3-2.3). even after adjusting by logistic regression for differences in age, stage, and histology. These treatment variables strongly affected five-year survival, after adjusting for age, singe, race, and histology. This finding of racial differences in survival-associated treatment patterns demonstrates thc need to consider treatment variables in studies of race and cancer survival. (Am J Public Health 1987: 77:1515-1517.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISCRIMINATION in medical care
KW - CANCER treatment
KW - CANCER patients -- Social conditions
KW - AFRICAN Americans
KW - WHITES
KW - BREAST cancer
KW - SURVIVAL behavior (Animals)
KW - CANCER -- Mortality
KW - PUBLIC health
KW - HUMAN services
N1 - Accession Number: 4949570; McWhorter, William P. 1 Mayer, William J. 1; Affiliation: 1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Dec1987, Vol. 77 Issue 12, p1515; Subject Term: DISCRIMINATION in medical care; Subject Term: CANCER treatment; Subject Term: CANCER patients -- Social conditions; Subject Term: AFRICAN Americans; Subject Term: WHITES; Subject Term: BREAST cancer; Subject Term: SURVIVAL behavior (Animals); Subject Term: CANCER -- Mortality; Subject Term: PUBLIC health; Subject Term: HUMAN services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kovar, Mary Grace
AU - Harris, Maureen I.
AU - Hadden, Wilbur C.
T1 - The Scope of Diabetes in the United States Population.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/12//
VL - 77
IS - 12
M3 - Article
SP - 1549
EP - 1550
PB - American Public Health Association
SN - 00900036
AB - The article discusses the national study entitled "Second National Health and Nutrition Examination Survey (NHANES II)," that was conducted by the U.S. National Center for Health Statistics from 1976-1980, which investigates the prevalence of diabetes in the population. This is the first national study wherein criteria of the World Health Organization and the National Diabetes Data Group have been used for administering the oral glucose tolerance tests and for classifying diabetes and glucose intolerance. The critical finding from NHANES II is that only about half of people with diabetes know that they are diabetic.
KW - HEALTH surveys -- United States
KW - DIABETES -- Research
KW - DIABETES -- Diagnosis
KW - DIABETICS
KW - CARBOHYDRATE intolerance
KW - PUBLIC health research
KW - PUBLIC health -- United States
KW - UNITED States
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4949599; Kovar, Mary Grace 1 Harris, Maureen I. 2 Hadden, Wilbur C. 3; Affiliation: 1: Office of Vital and Health Statistics Systems, NCHS 2: National Diabetes Data Group, National Institute of Diabetes and Digestive & Kidney Diseases, National Institutes of Health 3: Division of Health Examination Statistics, National Center for Health Statistics, 3700 East-West Highway, Room 2-58, Hyattsville, MD 20782; Source Info: Dec1987, Vol. 77 Issue 12, p1549; Subject Term: HEALTH surveys -- United States; Subject Term: DIABETES -- Research; Subject Term: DIABETES -- Diagnosis; Subject Term: DIABETICS; Subject Term: CARBOHYDRATE intolerance; Subject Term: PUBLIC health research; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Friedman, David I.
AU - Imperiale, Michael J.
AU - Adhya, Sankar L.
T1 - RNA 3' END FORMATION IN THE CONTROL OF GENE EXPRESSION.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1987/12//
VL - 21
M3 - Article
SP - 453
EP - 488
PB - Annual Reviews Inc.
SN - 00664197
AB - Discusses the terminator signals, the role of elongation and termination in regulation of expression, mechanisms of transcription elongation and termination in prokaryotes and similar mechanisms in eukaryotes. Types of terminator signals; Mechanism of termination at type I terminators; Importance of regulation of gene expression alternative 3' end formation and termination.
KW - GENE expression
KW - RNA
KW - TRANSCRIPTION factors
KW - PROKARYOTES
KW - GENETICS
KW - EUKARYOTIC cells
N1 - Accession Number: 12409440; Friedman, David I. 1 Imperiale, Michael J. 1 Adhya, Sankar L. 2; Affiliation: 1: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620 2: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892; Source Info: 1987, Vol. 21, p453; Subject Term: GENE expression; Subject Term: RNA; Subject Term: TRANSCRIPTION factors; Subject Term: PROKARYOTES; Subject Term: GENETICS; Subject Term: EUKARYOTIC cells; Number of Pages: 36p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104756551
T1 - Testicular cancer in young men: the search for causes of the epidemic increase in the United States.
AU - Brown, L M
AU - Pottern, L M
AU - Hoover, R N
Y1 - 1987/12//
N1 - Accession Number: 104756551. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766.
KW - Testicular Neoplasms -- Etiology
KW - Adolescence
KW - Adult
KW - Clothing -- Adverse Effects
KW - Cryptorchidism -- Complications
KW - District of Columbia
KW - Male
KW - Maryland
KW - Risk Factors
KW - Smoking
KW - Testicular Neoplasms -- Epidemiology
KW - Testicular Neoplasms -- Pathology
KW - Testis -- Injuries
KW - Testis -- Pathology
SP - 349
EP - 354
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
JA - J EPIDEMIOL COMMUNITY HEALTH
VL - 41
IS - 4
PB - BMJ Publishing Group
AB - A case-control study of 271 men with testicular cancer and 259 controls was conducted in the Washington, DC area to evaluate whether suggested risk factors could be responsible for the epidemic increases in testicular cancer in young men. No substantial risks were associated with a history of groin hernia operation, the common childhood diseases, allergies, x rays below the waist, venereal disease, vasectomy, or external means of elevating the temperature of the testis. Excess risks were associated with a history of undescended testis (RR = 3.7, CI = 1.5-9.5), testicular trauma (RR = 2.6, CI = 1.6-4.2), and mumps orchitis (RR = 5.8, CI = 0.7-129.7). It is unlikely, however, that any of these conditions has increased sufficiently over time to markedly affect the testicular cancer incidence patterns. Therefore, while the risk factors identified in this paper are of epidemiological interest, they do not account for the increase in testicular cancer in young men.
SN - 0143-005X
AD - Epidemiology and Biostatics Program, National Cancer Institute, Bethesda, MD 20892.
U2 - PMID: 2901454.
DO - 10.1136/jech.41.4.349
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Caughman, S. Wright
AU - Krieg, Thomas
AU - Timpl, Rupert
AU - Hintner, Helmut
AU - Katz, Stephen I.
T1 - Nidogen and Heparan Sulfate Proteoglycan: Detection of Newly Isolated Basement Membrane Components in Normal and Epidermolysis Bullosa Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1987/12//
VL - 89
IS - 6
M3 - Article
SP - 547
EP - 550
SN - 0022202X
AB - The epidermal basement membrane zone comprises various biochemical constituents, some of which may be affected or involved in certain forms of mechanobullous diseases. Recently, nidogen and a low density form of heparan sulfate proteoglycan--two ubiquitous, noncollagenous components of basement membranes--were isolated and characterized, and affinity-purified antibodies to each component were prepared. These antibodies were used to study the distribution of both antigens in normal and diseased human skin. By immunofluorescence, both nidogen and heparan sulfate proteoglycan were linearly distributed along the basement membrane of the dermal-epidermal junction, adnexal structures, and blood vessels of normal human skin. On suction-induced blisters of normal skin, both antigens were found at the base of the blister, indicating that each was within or below the lamina lucida. By indirect immunoelectron microscopy, both antigens were ultrastructurally located within the lamina densa. The staining patterns for nidogen and heparan sulfate proteoglycan were examined in 11 patients with either junctional, dominant dystrophic, or recessive dystrophic epidermolysis bullosa, and were found to be not different from the patterns observed in normal skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOGLYCANS
KW - GLYCOPROTEINS
KW - BIOLOGICAL interfaces
KW - EPIDERMOLYSIS bullosa
KW - EPITHELIUM
KW - BIOLOGICAL membranes
N1 - Accession Number: 12461192; Caughman, S. Wright 1 Krieg, Thomas 2 Timpl, Rupert 3 Hintner, Helmut 4 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Dermatologische Klinik und Poliklinik der Ludwig-Maximilians-Universitat, Munchen, F.R.G. 3: Max-Planck Institut fur Biochemie, Martinsried, F.R.G. 4: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.; Source Info: Dec87, Vol. 89 Issue 6, p547; Subject Term: PROTEOGLYCANS; Subject Term: GLYCOPROTEINS; Subject Term: BIOLOGICAL interfaces; Subject Term: EPIDERMOLYSIS bullosa; Subject Term: EPITHELIUM; Subject Term: BIOLOGICAL membranes; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12461192
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wittes, Janet
AU - Wallenstein, Sylvan
T1 - The Power of the Mantel-Haenszel Test.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1987/12//
VL - 82
IS - 400
M3 - Article
SP - 1104
SN - 01621459
AB - The Mantel-Haenszel (MH) test (Mantel and Haenszel 1959) is a widely used method for analyzing sets of two-by-two tables that compare the outcome of two treatments in several strata (Bailar and Anthony 1977). The procedure tests the null hypothesis of no partial association between treatment and outcome in any of the strata, or tables, against the alternative that the partial association, as measured by the common odds ratio, differs from 1. Birch (1964) showed that for a fixed number of tables, both the MH test and an earlier version due to Cochran (1954) are asymptotically identical to the uniformly most powerful unbiased test of this hypothesis. This article is concerned with calculating the power of the MH test as a prelude to embarking upon a study. We consider versions of the test with and without corrections for continuity. The spirit behind the approximations is that, although the odds ratio is the appropriate parameter for computing asymptotic power under local alternatives, in practice studies are designed for nonlocal alternatives. Our approach is based on evaluating a weighted difference of proportions of success in each table, rather than a weighted average of log-odds ratios, and is valid even if the odds ratios differ from table to table. The adequacy of our approximations to power is evaluated for planning three types of studies: the comparative binomial (CB), the double dichotomy (DD), and the survey (SY). In the CB trial, the proportion lambda[sub l] of patients in the ith strata, as well as the proportion rho[sub l] of patients in the ith strata who are assigned to the first treatment, are constants (I = 1, 2, ..., N). For the DD only the rho[sub l]'s are constant, whereas for the SY both vectors are random variables. We first approximate power under the condition that for each stratum NE(lambda[sub l]) is large. This approximation cannot distinguish between corrected and uncorrected statistics nor among the different sampling schemes. In some [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL hypothesis testing
KW - APPROXIMATION theory
KW - SAMPLING (Statistics)
KW - MATHEMATICAL statistics
KW - MULTIVARIATE analysis
KW - VARIABLES (Mathematics)
KW - BINOMIAL distribution
KW - SAMPLE size (Statistics)
KW - Conditional test.
KW - Partial associations
KW - Poststratification
KW - Sample size
N1 - Accession Number: 4610405; Wittes, Janet 1; Wallenstein, Sylvan 2; Affiliations: 1: Chief of the Biostatistics Research Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.; 2: Associate Professor of Clinical Public Health, Division of Biostatistics, Columbia University School of Public Health, New York, NY 10032.; Issue Info: Dec87, Vol. 82 Issue 400, p1104; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: MULTIVARIATE analysis; Subject Term: VARIABLES (Mathematics); Subject Term: BINOMIAL distribution; Subject Term: SAMPLE size (Statistics); Author-Supplied Keyword: Conditional test.; Author-Supplied Keyword: Partial associations; Author-Supplied Keyword: Poststratification; Author-Supplied Keyword: Sample size; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Roberts, Bruce R.
T1 - A Confirmatory Factor-Analytic Model of Alienation.
JO - Social Psychology Quarterly
JF - Social Psychology Quarterly
Y1 - 1987/12//
VL - 50
IS - 4
M3 - Article
SP - 346
EP - 351
SN - 01902725
AB - This paper presents a longitudinal second-order confirmatory factor-analytic model of alienation in employed U.S. men, based on Seeman's original five-facet conceptualization. Alienation appears in this model as a second -order factor that is significantly related to all five of these facets. Powerlessness and self-estrangement are shown to be the two central facets. Meaninglessness, normlessness and cultural estrangement show progressively smaller relationships to the underlying alienation construct. Although cultural estrangement is significantly related to the underlying construct, removing it results in a model that fits the data slightly better, Cross-national comparisons using cross-sectional data from Poland and Japan confirm the generalizability of this model. However, the magnitudes of the relationships of both normlessness and cultural estrangement to the second-order factor are somewhat different for Japan than for the United States and Poland. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Psychology Quarterly is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALIENATION (Social psychology)
KW - SOCIAL psychology
KW - DEPERSONALIZATION
KW - SOCIAL isolation
KW - FACTOR analysis
KW - FACTOR structure
N1 - Accession Number: 13571329; Roberts, Bruce R. 1; Affiliation: 1: National institute of Mental Health.; Source Info: Dec87, Vol. 50 Issue 4, p346; Subject Term: ALIENATION (Social psychology); Subject Term: SOCIAL psychology; Subject Term: DEPERSONALIZATION; Subject Term: SOCIAL isolation; Subject Term: FACTOR analysis; Subject Term: FACTOR structure; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 119722332
T1 - Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization.
AU - Croen, K D
AU - Ostrove, J M
AU - Dragovic, L J
AU - Smialek, J E
AU - Straus, S E
Y1 - 1987/12/03/
N1 - Accession Number: 119722332. Language: English. Entry Date: 20161118. Revision Date: 20161127. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Sensory Integration and Praxis Tests (SIPT) (Ayres). NLM UID: 0255562.
KW - Proteins
KW - Genes
KW - RNA
KW - Herpes Simplex -- Microbiology
KW - Herpesviruses
KW - Trigeminal Nerve -- Microbiology
KW - Ganglia, Sensory -- Microbiology
KW - Middle Age
KW - Herpesviruses -- Immunology
KW - Adult
KW - Enzymes
KW - Aged
KW - Child
KW - Nucleic Acid Hybridization
KW - Adolescence
KW - RNA -- Analysis
KW - Antibodies, Viral -- Analysis
SP - 1427
EP - 1432
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 317
IS - 23
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - We used in situ hybridization to study the expression of herpes simplex virus type 1 genes during latent infections of human sensory ganglia. Trigeminal ganglia were recovered at autopsy from 24 subjects with no evidence of an active herpetic infection. These ganglia were hybridized to 35S-labeled single-stranded RNA probes spanning 72 percent of the herpes simplex genome. In the ganglia of 16 subjects, 0.2 to 4.3 percent of the neuronal cells contained abundant nuclear signals for viral RNA. Ganglia from three patients with low or undetectable levels of antibodies to herpes simplex type 1 lacked viral RNA signals, whereas the ganglia from all of six patients with elevated antibody titers showed viral RNA signals. Transcription was detected only from the region of the viral genome containing a gene that encodes an immediate early protein known as the infected-cell protein number zero (ICP0). However, normal ("sense") transcripts of this gene, which are prominent in an acute infection, were not detected. In contrast, a novel transcript was found overlapping with, but opposite in direction to, the ICP0 transcript (and was therefore "anti-sense"). Although this transcript has been only partially characterized, we believe that it may have a role in maintaining the latency of herpes simplex virus.
SN - 0028-4793
AD - Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Md
U2 - PMID: 2825014.
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DB - rzh
ER -
TY - JOUR
AU - VELU, THIERRY J.
AU - BEGUINOT, LAURA
AU - VASS, WILLIAM C.
AU - WILLINGHAM, MARK C.
AU - MERLINO, GLENN T.
AU - PASTAN, IRA
AU - LOWY, DOUGLAS R.
T1 - Epidermal Growth Factor-Dependent Transfortion by a Human EGF Receptor Proto-Oncogene.
JO - Science
JF - Science
Y1 - 1987/12/04/
VL - 238
IS - 4832
M3 - Article
SP - 1408
EP - 1410
SN - 00368075
AB - The epidernal growth factor (EGF) receptor gene EGFR has been placed in a retrovirus vector to examine the growth properties of cells that experimentally overproduce a full-length EGF receptor. NIH 3T3 cells transfected with the viral DNA or infected with the corresponding rescued retrovirus developed a fully transformed phenotype in vitro that required both functional EGFR expression and the presence of EGF in the growth medium. Cells expressing 4 × 103 EGF receptors formed tumors in nude mice, while control cells did not. Therefore, the EGFR retrovirus, which had a titer on NIH 3T3 cells that was greater than 107 focus-forming units per milliliter, can efficiently transfer and express this gene, and increased numbers of EGF receptors can contribute to the transformed phenotype. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84692567; VELU, THIERRY J. 1 BEGUINOT, LAURA 2 VASS, WILLIAM C. 1 WILLINGHAM, MARK C. 2 MERLINO, GLENN T. 2 PASTAN, IRA 2 LOWY, DOUGLAS R. 1; Affiliation: 1: Laboratory of Ccllular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 2: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 12/ 4/1987, Vol. 238 Issue 4832, p1408; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bender, B. S.
AU - Winchurch, R. A.
AU - Thupari, J. N.
AU - Proust, J. J.
AU - Adler, W. H.
AU - Munster, A. M.
T1 - Depressed natural killer cell function in thermally injured adults: successful in vivo and in vitro immunomodulation and the role of endotoxin.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1988/01//
VL - 71
IS - 1
M3 - Article
SP - 120
EP - 125
PB - Wiley-Blackwell
SN - 00099104
AB - Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target cell lysis = 22.0 ± 3.1% vs 39.8 ± 3.2% in healthy volunteers, P < 0.001) and also a lower response to IL-2 (28.9 ± 3.8% vs 53.2 ± 4.3%, P < 0.001). Thirteen burn patients were randomly assigned lo receive either standard therapy or 5 days of intravenous polymyxin B in addition fo standard therapy. After 2 weeks, the patients not receiving polymyxin B had a significant decline in peripheral blood NK activity (P < 0.01) and response to IL-2 (P < 0.05), white no decline in NK cell activity was seen in patients who received polymyxin B. Sera from burn patients was found to suppress the NK activity of lymphocytes from healthy adults by 5-75%. After using affinity chromatography to remove endotoxin, the sera from burn patients no longer suppressed NK cell activity. Circulating endotoxin appears to be involved in the suppression of NK activity in burn patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - INTERLEUKIN-2
KW - ENDOTOXINS
KW - IMMUNE response -- Regulation
KW - LYMPHOCYTES
KW - POLYMYXIN
KW - burn
KW - endotoxin
KW - IL-2
KW - NK cells
KW - polymyxin B
N1 - Accession Number: 16201686; Bender, B. S. 1,2 Winchurch, R. A. 1,2 Thupari, J. N. 1,2 Proust, J. J. 1,2 Adler, W. H. 1,2 Munster, A. M. 1,2; Affiliation: 1: Clinical Immunology Section, National Institute on Aging, NIH, Baltimore, USA. 2: Baltimore, Regional Burn Center, Department of Surgery, Francis Scott Key Medical Center, A Johns Hopkins Medical Institution, Baltimore, USA.; Source Info: Jan1988, Vol. 71 Issue 1, p120; Subject Term: KILLER cells; Subject Term: INTERLEUKIN-2; Subject Term: ENDOTOXINS; Subject Term: IMMUNE response -- Regulation; Subject Term: LYMPHOCYTES; Subject Term: POLYMYXIN; Author-Supplied Keyword: burn; Author-Supplied Keyword: endotoxin; Author-Supplied Keyword: IL-2; Author-Supplied Keyword: NK cells; Author-Supplied Keyword: polymyxin B; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burns, Barbara J.
AU - Larson, David B.
AU - Goldstrom, Ingrid D.
AU - Johnson, Wayne E.
AU - Taube, Carl A.
AU - Miller, Nancy E.
AU - Mathis, Evelyn s.
T1 - MENTAL DISORDER AMONG NURSING HOME PATIENTS: PRELIMINARY FINDINGS FROM THE NATIONAL NURSING HOME SURVEY PRETEST.
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
Y1 - 1988/01//Jan-Mar1988
VL - 3
IS - 1
M3 - Article
SP - 27
EP - 35
PB - John Wiley & Sons, Inc.
SN - 08856230
AB - Ninety-six per cent of mentally ill elderly persons who are not in the community reside in nursing homes, yet the mental health care they receive there is minimal or unavailable. Data are presented from the 1984 pretest of the National Nursing Home Survey. Five hundred and twenty-six patients in 112 nursing homes in four US metropolitan areas were sampled. Overall, the prevalence of mental disorder was found to be 68%; 39% of the patients had a diagnosis of organic brain syndrome (OBS) and 29% had other mental disorders (OMD). Only about one-third (31%) or residents had no mental disorder. These three patient groups, those with OBS, those with OMD, and those with no mental disorder, were compared on demographic, clinical, and treatment characteristics. The authors conclude that the balance between the Federal and State roles in financing care for the mentally ill in nursing homes needs to result in a more equitable system of care which does not discriminate against the mentally ill. Further, the mental health service system needs to assume greater responsibility for this populations. While significant attention is given to residents physical needs, behavioural and emotional problems are seriously neglected. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - MENTAL illness
KW - NURSING home patients
KW - NEUROBEHAVIORAL disorders
KW - GERIATRICS
KW - MENTAL health services
KW - elderly
KW - geriatrics.
KW - Nursing homes
KW - prevalence
N1 - Accession Number: 12181496; Burns, Barbara J. 1 Larson, David B. 2 Goldstrom, Ingrid D. 2 Johnson, Wayne E. 2 Taube, Carl A. 2 Miller, Nancy E. 2 Mathis, Evelyn s. 3; Affiliation: 1: Department of Psychiatry, University of Maryland Medical School, 645 W. Redwood St. Baltimore, Maryland, 21201 USA. 2: National Institute of Mental Health. 3: National Center for Health Statistics.; Source Info: Jan-Mar1988, Vol. 3 Issue 1, p27; Subject Term: MENTAL health; Subject Term: MENTAL illness; Subject Term: NURSING home patients; Subject Term: NEUROBEHAVIORAL disorders; Subject Term: GERIATRICS; Subject Term: MENTAL health services; Author-Supplied Keyword: elderly; Author-Supplied Keyword: geriatrics.; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: prevalence; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104758911
T1 - Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure.
AU - Bielory, L
AU - Gascon, P
AU - Lawley, T J
AU - Young, N S
AU - Frank, M M
Y1 - 1988/01//1988 Jan
N1 - Accession Number: 104758911. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R.
KW - Anemia, Aplastic -- Therapy
KW - Antilymphocyte Serum -- Therapeutic Use
KW - Bone Marrow -- Physiopathology
KW - Serum Sickness -- Complications
KW - T Lymphocytes -- Immunology
KW - Adolescence
KW - Adult
KW - Aged
KW - Anemia, Aplastic -- Etiology
KW - Antigens -- Analysis
KW - Antilymphocyte Serum -- Adverse Effects
KW - Child
KW - Female
KW - Hematopoiesis
KW - Human
KW - Immunoglobulins -- Analysis
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Random Assignment
KW - Serum Sickness -- Immunology
KW - Serum Sickness -- Physiopathology
KW - Clinical Trials
SP - 40
EP - 57
JO - Medicine
JF - Medicine
JA - MEDICINE
VL - 67
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - We have prospectively evaluated the clinical and immunological features of serum sickness in 35 patients treated for bone marrow failure with anti-thymocyte globulin (ATG 15 mg/kg/day) and methylprednisolone (1 to 1.5 mg/kg/day). Twenty-one patients were treated for 10 days and 14 were treated for 28 days. Clinical evidence of serum sickness developed in 30 patients (86%) and included fever and malaise (100%), cutaneous eruptions (93%), arthralgias (67%), gastrointestinal complaints (67%), cephalgia (57%), blurring of vision (37%), arthritis, (30%) and lymphadenopathy (13%). Clinical serum sickness began on day 7 +/- 1 (X +/- S.E.M.) and lasted for 10 +/- 2 days in the 18 affected patients receiving the shorter course of ATG. In the 12 affected patients receiving the longer course of ATG, serum sickness began on day 9 +/- 1. The earliest manifestations of serum sickness were fever, malaise, and cutaneous eruptions. Cutaneous findings consisted of morbilliform eruptions (n = 19) and urticaria (n = 1) or a combination (n = 8) that lasted 10 to 14 days. Twenty-one patients (75%) developed a highly characteristic serpiginous band of erythema and purpura along the sides of the fingers, toes, palms and soles 12 to 48 hours before other symptoms of serum sickness. Biopsies of lesional skin during the course of serum sickness revealed immune deposits (IgM, IgE, IgA and C3) in dermal vasculature in 7 of 9 patients. Immunological changes that occurred during the course of serum sickness included increased serum levels of IgG, IgM, IgA, and IgE. Circulating immune complexes, as measured by the C1q-binding assay, increased from a mean value of 12% to 45% on day 13 +/- 1. Complement levels (C3, C4, and CH50) decreased 50 to 80% from their baseline levels on day 10 +/- 2. Acute phase reactants increased: erythrocyte sedimentation rate, C-reactive protein and beta-2 microglobulin. Abnormal urinalysis developed in 17 patients (57%) over the course of serum sickness and included proteinuria, hematuria and hemoglobinuria on day 10 +/- 3. Hematopoietic response occurred in 43%. All 5 patients who did not develop serum sickness recovered from bone marrow failure. Our data document the clinical and immunopathological findings in human serum sickness and suggest that the principles of antigen-antibody interaction, complement activation, and resultant inflammatory response as seen in the previous animal studies are directly applicable to studies of patients with serum sickness.
SN - 0025-7974
AD - Clinical Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland.
U2 - PMID: 3257288.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104758911&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2008-08920-001
AN - 2008-08920-001
AU - Lenfant, Claude M.
T1 - Preface.
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1988///
VL - 7
IS - Suppl
SP - 1
EP - 2
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
N1 - Accession Number: 2008-08920-001. Partial author list: First Author & Affiliation: Lenfant, Claude M.; National Heart, Lung, and Blood Institute, Bethesda, MD, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20100104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hypertension; Scientific Communication. Classification: Cardiovascular Disorders (3295). Population: Human (10). Location: US. Page Count: 2. Issue Publication Date: 1988. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1988.
AB - Reports on the Fifth Joint USA-USSR Symposium on Arterial Hypertension, which was held in Easton, Maryland on March 23-24, 1987. The scientific contributions contained in this Health Psychology supplement are the proceedings from this symposium. The symposium was sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health as part of the USA-USSR research collaboration in arterial hypertension. This joint effort is conducted under a bilateral agreement between the governments of the United States and the Soviet Union in a variety of cardiovascular research fields. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - arterial hypertension
KW - USA-USSR Symposium
KW - 1988
KW - Hypertension
KW - Scientific Communication
KW - 1988
DO - 10.1037/h0090268
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08920-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-003
AN - 2005-26897-003
AU - Goodwin, Frederick K.
T1 - Foreword.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 141
EP - 143
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Goodwin, Frederick K., Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-003. Partial author list: First Author & Affiliation: Goodwin, Frederick K.; Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Cerebral Blood Flow; Mental Health; Neurosciences; Schizophrenia. Minor Descriptor: At Risk Populations; Tomography. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 3. Issue Publication Date: 1988.
AB - The article introduces the papers included in the present issue of Schizophrenia Bulletin. As the world's largest mental health and neuroscience research center, the Intramural Research Program (IRP) of the National Institute of Mental Health (NIMH) has played a major role in many of the scientific advances that are now beginning to unravel the mystery of schizophrenia. We owe much of this progress to certain unique strengths of the IRP research environment. IRP science has contributed to the development of metabolic brain imaging, which has opened new windows into the functional neuroanatomy of schizophrenia. In the late 1940's and early 1950's, Dr. Seymour Kety, IRP's first Scientific Director, conceived the idea of using inert diffusible tracers to study cerebral blood flow, developing the theory and equations which made this possible. A more recent IRP conceptual development derives from Dr. Robert Post's studies of kindling in animals and its possible relationship to mood disorders, particularly rapid-cycling bipolar mood disorder. Carbamazepine, an antikindling drug, was then found to be effective in treating rapidly cycling patients, most of whom are resistant to lithium. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - mental health
KW - neuroscience research
KW - cerebral blood flow
KW - mood disorders
KW - 1988
KW - Bipolar Disorder
KW - Cerebral Blood Flow
KW - Mental Health
KW - Neurosciences
KW - Schizophrenia
KW - At Risk Populations
KW - Tomography
KW - 1988
DO - 10.1093/schbul/14.2.141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-005
AN - 2005-26897-005
AU - Mirsky, Allan F.
T1 - Research on Schizophrenia in the NIMH Laboratory of Psychology and Psychopathology, 1954-1987.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 151
EP - 156
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, NIMH, NIH, Bldg. 10, Rm. 4C110, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-005. PMID: 3059464 Partial author list: First Author & Affiliation: Mirsky, Allan F.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Autonomic Nervous System; Evoked Potentials; Psychopathology; Schizophrenia. Minor Descriptor: Etiology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1988.
AB - Since its creation in 1954 (as the Laboratory of Psychology) through the present time, the Laboratory of Psychology and Psychopathology has devoted a major effort to the study of schizophrenia. Shakow's studies on impaired reaction time performance led to the development of the concept of segmental set; Rosenthal's work on genetic factors in the etiology of schizophrenia, as well as on the interaction of stress and diathesis, helped to illuminate the nature of transmission of schizophrenia. These investigations set standards of excellence for careful analysis of psychopathological behavior. Our present program of research on schizophrenia emphasizes autonomic, psychophysiological and event-related brain potential investigations of schizophrenic patients and long-term followup of a high-risk population in Israel. In this group, poor attention in children at genetic risk has proved to be a predictor of later development of a schizophrenia spectrum disorder. Our work also emphasizes a theoretical analysis of the neuropsychological elements that make up attention in relation to psychopathological states. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - psychopathological behavior
KW - autonomic system
KW - event related brain potential
KW - at risk population
KW - 1988
KW - At Risk Populations
KW - Autonomic Nervous System
KW - Evoked Potentials
KW - Psychopathology
KW - Schizophrenia
KW - Etiology
KW - 1988
DO - 10.1093/schbul/14.2.151
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-007
AN - 2005-26897-007
AU - Cohen, Robert M.
AU - Semple, William E.
AU - Gross, Michael
AU - Nordahl, Thomas E.
T1 - From Syndrome to Illness: Delineating the Pathophysiology of Schizophrenia With PET.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 169
EP - 176
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Cohen, Robert M., Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, NIMH, NIH, Bldg. 10, 4N317, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-007. PMID: 3059466 Partial author list: First Author & Affiliation: Cohen, Robert M.; Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neurochemistry; Prefrontal Cortex; Schizophrenia; Syndromes; Tomography. Minor Descriptor: Auditory Discrimination; Pathophysiology; Sustained Attention. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: 1988.
AB - The Section on Clinical Brain Imaging of the Laboratory of Cerebral Metabolism has been engaged in studying regional brain metabolism by positron emission tomography (PET) to establish the pathophysiology of schizophrenia. Recent studies have revealed that the fluorodeoxyglucose (FDG) PET methodology can be applied successfully to determine the anatomical substrata of directed attention. In normal controls, the metabolic rate in the middle prefrontal cortex, measured during the ongoing performance of auditory discrimination, is associated with their accuracy of performance. In unmedicated patients with schizophrenia, even those who performed as well as normals, the metabolic rate in the mid-prefrontal cortex was found to be significantly lower than normal. Further, this decreased metabolic rate was unrelated to performance. In medicated patients with schizophrenia, at least part of the metabolic deficit remains, but this deficit appears to be performance-related. These findings suggest several conclusions. The mid-prefrontal cortex and its dopamine neurotransmitter pathway input are important biological determinants of sustained attention. Two types of prefrontal metabolic deficits may contribute to dysfunctional goal-directed behavior and, more speculatively, vulnerability to psychosis in some patients with schizophrenia. One deficit is sensitive to neuroleptics, and thus presumably to a change in the balance of regional brain dopamine input. A second deficit is unaffected by neurolpetic treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - brain metabolism
KW - prefrontal cortex
KW - pathophysiology
KW - schizophrenia
KW - positron emission tomography
KW - sustained attention
KW - auditory discrimination
KW - 1988
KW - Neurochemistry
KW - Prefrontal Cortex
KW - Schizophrenia
KW - Syndromes
KW - Tomography
KW - Auditory Discrimination
KW - Pathophysiology
KW - Sustained Attention
KW - 1988
DO - 10.1093/schbul/14.2.169
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-011
AN - 2005-26897-011
AU - Duncan, Connie C.
T1 - Event-Related Brain Potentials: A Window on Information Processing in Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 199
EP - 203
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Duncan, Connie C., Unit on Psychophysiology, Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C110, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-011. PMID: 2904693 Partial author list: First Author & Affiliation: Duncan, Connie C.; Unit on Psychophysiology, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Evoked Potentials; Schizophrenia. Minor Descriptor: Brain. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: 1988.
AB - The application of the P300 component of the event-related brain potential to the study of attentional impairment in schizophrenia is discussed, and two recent studies are described. In one, the relative effects on P300 of stimulus modality and probability were evaluated. The data showed that the P300 is smaller in schizophrenic patients relative to normal controls for low-probability auditory stimuli. Next is described a preliminary report that evaluated whether this P300 reduction reflects a core deficit (trait marker) or clinical symptomatology (state marker). To pursue this question, a group of schizophrenic patients was studied on and off neuroleptic medication. The data showed that improvement in clinical state was highly correlated with increased visual P300 but was uncorrelated with auditory P300. These findings suggest that P300 elicited in the visual modality has the characteristics of a state marker of schizophrenia. In contrast, auditory P300 remains a candidate for a vulnerability trait marker of schizophrenia. The core deficit in schizophrenia thus appears to involve the auditory information-processing system, whereas fluctuations in clinical state may be reflected in the visual processing system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - event related brain potential
KW - schizophrenia
KW - auditory information processing system
KW - visual information processing
KW - 1988
KW - Cognitive Processes
KW - Evoked Potentials
KW - Schizophrenia
KW - Brain
KW - 1988
DO - 10.1093/schbul/14.2.199
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-014
AN - 2005-26897-014
AU - Kety, Seymour S.
T1 - Schizophrenic Illness in the Families of Schizophrenic Adoptees: Findings from the Danish National Sample.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 217
EP - 222
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Kety, Seymour S., Laboratory of Psychology and Psychopathology, NIMH, Bldg. 10, Rm. 4C-212, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-014. PMID: 3201179 Partial author list: First Author & Affiliation: Kety, Seymour S.; Laboratory of Psychology and Psychopathology, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adoptees; Biological Family; Schizophrenia. Minor Descriptor: Schizotypal Personality Disorder. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Denmark. References Available: Y. Page Count: 6. Issue Publication Date: 1988.
AB - The prevalence of schizophrenic illness in the biological and adoptive relatives of schizophrenic adoptees has been examined in a total sample of adoptees in Denmark. The sample was studied in two stages, beginning with the Copenhagen sample of adoptions granted by the courts in the city and county of Copenhagen, and the results have been reported previously. The adoptions granted by the courts in the remainder of Denmark made up the Provincial sample, the preliminary results of which appear to confirm those obtained earlier. Chronic schizophrenia and milder syndromes described as latent, borderline, or uncertain schizophrenia, and in DSM-III as schizotypal personality disorder, were found in both samples to concentrate significantly in the biological relatives of schizophrenic adoptees as compared to their controls, but not in their adoptive relatives. These milder and marginal syndromes resembling schizophrenia occurring in the families of schizophrenic patients confirm the observations of Bleuler and others who succeeded him. Their presence in the biological families of schizophrenic adoptees indicates not only their familial, but also their genetic relationship to schizophrenia, although the specificity of that relationship has not been established. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenic adoptees
KW - schizophrenic illness
KW - schizotypal personality disorder
KW - biological family
KW - 1988
KW - Adoptees
KW - Biological Family
KW - Schizophrenia
KW - Schizotypal Personality Disorder
KW - 1988
DO - 10.1093/schbul/14.2.217
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-017
AN - 2005-26897-017
AU - Pert, Candace B.
AU - Knight, John G.
AU - Laing, Peter
AU - Markwell, Ann K.
T1 - Scenarios for a Viral Etiology of Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 243
EP - 247
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Pert, Candace B., Section of Brain Biochemistry, Clinical Neuroscience Branch, Bldg. 36, Rm. 2D-30, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-017. PMID: 3059471 Partial author list: First Author & Affiliation: Pert, Candace B.; Section on Brain Biochemistry, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Etiology; Genetics; Immunology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 5. Issue Publication Date: 1988.
AB - Recent discoveries in the field of virus receptors have revolutionized our concepts of viral pathogenesis. The lysis of cells resulting from virus infection or immune recognition of infected cells is seen as merely one facet of a spectrum of pathogenic mechanisms which may be subtle and complex. This is particularly relevant to the central nervous and immune systems which share cell-surface receptors for various neuropeptides and neurotransmitters. A number of viruses are now known to share receptors for such endogenous ligands; indeed, some viruses (e.g., human immunodeficiency virus and vaccinia) may themselves be structural analogs of these ligands. There is, therefore, considerable scope for interference by viruses in the normal functioning of the brain and neuroendocrine systems. Brief reactive psychoses are occasionally reported as acute sequels to viral infections, but generally these are regarded as unrelated to schizophrenia. An opposite viewpoint is presented in the article: i.e., that the only reason these reactive psychoses do not progress to schizophrenia is that the majority of individuals affected are not predisposed genetically to schizophrenia. Conceivably, therefore, the genetic predisposition to schizophrenia may be attributable to genes which determine idiosyncratic differences in immune responsiveness to common viral pathogens. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - viral etiology
KW - virus infection
KW - schizophrenia
KW - central nervous systems
KW - immune system
KW - neuroendocrine systems
KW - genetics
KW - 1988
KW - Central Nervous System
KW - Etiology
KW - Genetics
KW - Immunology
KW - Schizophrenia
KW - 1988
DO - 10.1093/schbul/14.2.243
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-018
AN - 2005-26897-018
AU - Merril, Carl R.
AU - Harrington, Michael G.
T1 - Use of Two-Dimensional Electrophoretic Protein Maps in Studies of Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 249
EP - 254
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Merril, Carl R., Laboratory of Preclinical Pharmacology, NIMH, NIH Clinical Center, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-018. PMID: 3059472 Partial author list: First Author & Affiliation: Merril, Carl R.; Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antibodies; Cerebrospinal Fluid; Genes; Proteins; Schizophrenia. Minor Descriptor: Amino Acids; Body Fluids; Technology. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: 1988.
AB - High resolution two-dimensional electrophoresis (2DE) and silver staining have provided a technology capable of mapping large numbers of proteins from tissues and body fluids. Further identification of individual proteins that have been visualized by 2DE includes their characterization by immunodetection methods and by obtaining amino acid sequences from which antibody and synthetic oligonucleotide probes can be synthesized. As many as 3,500 individual proteins may be observed on a single electrophoretogram. This capacity to observe gene products permits the scanning of as many as 3.5 megabases of the protein coding regions of the genome for mutational events on each gel, and may also provide evidence concerning abnormal rates of protein synthesis or degradation, posttranslational modifications, and the presence of gene products of exogenous origin. The application of this technology has revealed a pair of abnormal cerebrospinal fluid (CSF) proteins (40KD) in one-third of schizophrenic patients screened. These abnormal proteins have never been observed in CSF from normal controls. However, they have been detected in some diseases of the central nervous system that may be of viral origin. Structural studies on these proteins should provide evidence of their origin, while ongoing studies of brain proteins may provide additional clues about this disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - electrophoretic protein maps
KW - schizophrenia
KW - amino acid sequences
KW - antibody
KW - oligonucleotide probes
KW - cerebrospinal fluid
KW - 1988
KW - Antibodies
KW - Cerebrospinal Fluid
KW - Genes
KW - Proteins
KW - Schizophrenia
KW - Amino Acids
KW - Body Fluids
KW - Technology
KW - 1988
DO - 10.1093/schbul/14.2.249
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-019
AN - 2005-26897-019
AU - Pickar, David
T1 - Perspectives on a Time-Dependent Model of Neuroleptic Action.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 255
EP - 268
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Pickar, David, Section on Clinical Studies, Clinical Neuroscience Branch, NIMH, NIH Clinical Center, Bldg. 10, Rm. 4N-214, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26897-019. PMID: 2904694 Partial author list: First Author & Affiliation: Pickar, David; Section on Clinical Studies, Clinical Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Central Nervous System; Dopamine Metabolites; Neuroleptic Drugs; Pathophysiology; Schizophrenia. Minor Descriptor: Dopamine; Homovanillic Acid; Neural Receptors. Classification: Clinical Psychopharmacology (3340). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: 1988.
AB - The best support for the hypothesized involvement of central nervous system dopamine systems in the pathophysiology of schizophrenia is the association between the affinity of neuroleptic drugs for the D₂ dopamine receptor and their potency as antipsychotics. Discrepancy between the time course of receptor binding and the development of antipsychotic effects, however, limits this model. Preclinical studies have now shown that activation of presynaptic nigrostriatal and mesolimbic dopamine neurons by acute neuroleptic administration is reversed during chronic administration. Clinically, neuroleptic-induced time-dependent reductions in plasma levels of the dopamine metabolite, homovanillic acid (HVA), have been linked to the antipsychotic response in schizophrenic patients. These data support the notion that slowly developing alterations in presynaptic dopamine activity play a role in the mechanism of action of neuroleptic drugs. Differences between plasma and cerebrospinal fluid (CSF) HVA responses to neuroleptic treatment, although not fully explained, may be related to prominent contributions of mesocortical metabolism to CSF levels of HVA. A time-dependent dopaminergic model of neuroleptic action with implications for the pharmacotherapy of schizophrenia is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroleptic drugs
KW - mesolimbic dopamine neurons
KW - antipsychotic response
KW - dopamine receptor
KW - dopamine metabolites
KW - central nervous system
KW - pathophysiology
KW - 1988
KW - Central Nervous System
KW - Dopamine Metabolites
KW - Neuroleptic Drugs
KW - Pathophysiology
KW - Schizophrenia
KW - Dopamine
KW - Homovanillic Acid
KW - Neural Receptors
KW - 1988
DO - 10.1093/schbul/14.2.255
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-019&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-021
AN - 2005-26897-021
AU - Shore, David
AU - Filson, C. Richard
AU - Johnson, Wayne E.
T1 - Violent Crime Arrests and Paranoid Schizophrenia: The White House Case Studies.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 279
EP - 281
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Shore, David, Biological and Clinical Factors Research Program, Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-26897-021. PMID: 3201180 Partial author list: First Author & Affiliation: Shore, David; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hallucinations; Homicide; Legal Arrest; Paranoid Schizophrenia; Violent Crime. Classification: Schizophrenia & Psychotic States (3213); Criminal Law & Adjudication (4230). Population: Human (10); Male (30). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 3. Issue Publication Date: 1988.
AB - We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder or assault arrests before and/or after their WHC hospitalizations. During the 9-12 years following discharge, 31 of the 217 male WHCs (for whom adequate clinical records were available) had murder or assault arrests. Demographic characteristics such as prior violent crime arrest and male gender proved to be much better predictors of future violence than clinical symptom, history, or behavior items. Hospital incidents requiring seclusion and a history of weapons possession were both associated with later violence in WHCs with prior violent crime arrests, while certain clinical symptoms (e.g., persecutory delusions and command hallucinations) may be linked to future violence in WHCs without prior violent crime arrests. These data need replication in other patient samples. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violent crime arrests
KW - paranoid schizophrenia
KW - murder
KW - assault
KW - demographic characteristics
KW - hallucinations
KW - 1988
KW - Hallucinations
KW - Homicide
KW - Legal Arrest
KW - Paranoid Schizophrenia
KW - Violent Crime
KW - 1988
DO - 10.1093/schbul/14.2.279
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-021&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26897-022
AN - 2005-26897-022
AU - Kirch, Darrell G.
AU - Bigelow, Llewellyn B.
AU - Korpi, Esa R.
AU - Wagner, Richard L.
AU - Zalcman, Steven
AU - Wyatt, Richard Jed
T1 - Serum Haloperidol Concentration and Clinical Response in Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 2
SP - 283
EP - 289
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Kirch, Darrell G., Neuropsychiatry Branch, Intramural Research Program, NIMH, Neuropsychiatric Research Hospital at Saint Elizabeths, 2700 Martin Luther King, Jr. Ave., Washington, DC, US, 20032
N1 - Accession Number: 2005-26897-022. PMID: 3201181 Partial author list: First Author & Affiliation: Kirch, Darrell G.; Neuropsychiatric Research Hospital, NIMH, Neuropsychiatric Research Hospital at St. Elizabeths, Washington, DC, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blood Serum; Drug Therapy; Haloperidol; Schizophrenia; Treatment Outcomes. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Brief Psychiatric Rating Scale DOI: 10.1037/t01554-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 1988.
AB - Previous studies have reported a therapeutic window (i.e., a curvilinear relationship between clinical response and drug level) for haloperidol concentrations in serum or plasma. The authors treated 30 acutely decompensated schizophrenic inpatients with a fixed dose of haloperidol (.4 mg/kg/day). After 6 weeks there was no statistically significant correlation between clinical improvement and serum haloperidol concentration. Fifteen subjects with serum concentrations of 5-15 ng/ml did not differ in clinical improvement compared with 15 subjects who had concentrations above 15 ng/ml. These data are consistent with a therapeutic plateau, rather than a window, and suggest that in most cases there is no clinical advantage to the use of haloperidol doses greater than approximately 30 mg/day in schizophrenic patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serum haloperidol concentration
KW - schizophrenia
KW - clinical response
KW - blood serum
KW - 1988
KW - Blood Serum
KW - Drug Therapy
KW - Haloperidol
KW - Schizophrenia
KW - Treatment Outcomes
KW - 1988
DO - 10.1093/schbul/14.2.283
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26897-022&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09725-001
AN - 2005-09725-001
AU - Keith, Samuel J.
AU - Matthews, Susan M.
T1 - A National Plan for Schizophrenia Research: Panel Recommendations-- Editors' Introduction.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 3
SP - 343
EP - 343
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Keith, Samuel J., Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09725-001. Partial author list: First Author & Affiliation: Keith, Samuel J.; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Etiology; Public Health Services; Schizophrenia; Treatment; Health Care Policy. Minor Descriptor: Mental Health Services. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 1. Issue Publication Date: 1988.
AB - In 1986, the National Institute of Mental Health (NIMH) designated schizophrenia as its foremost research priority. In doing so, NIMH recognized the enormous public health challenge posed by schizophrenia, acknowledged the immense and chronic burden borne by people with this disorder and their families, and made a commitment to rapidly advance the state of knowledge about the illness. The development of the National Plan was undertaken with the awareness that there are no simple and unequivocal answers to the challenges posed by schizophrenia, and the research opportunities detailed in these reports assume that future research efforts will necessarily be challenging, extensive, and complex if they are to provide us with a better understanding of the causes, prevention, and treatment of the most devastating of all mental disorders-schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - public health mental disorders
KW - treatment
KW - public health policy
KW - 1988
KW - Etiology
KW - Public Health Services
KW - Schizophrenia
KW - Treatment
KW - Health Care Policy
KW - Mental Health Services
KW - 1988
DO - 10.1093/schbul/14.3.343
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09725-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09725-009
AN - 2005-09725-009
AU - Andreasen, Nancy C.
AU - Carson, Richard
AU - Diksic, Mirko
AU - Evans, Alan
AU - Farde, Lars
AU - Gjedde, Albert
AU - Hakim, Antoine
AU - Lal, Samarthji
AU - Nair, Neelakanta
AU - Sedvall, Göran
AU - Tune, Larry
AU - Wong, Dean
T1 - Workshop on Schizophrenia, PET, and Dopamine D₂ Receptors in the Human Neostriatum.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 3
SP - 471
EP - 484
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Gjedde, Albert, Montreal Neurological Institute and Hospital, 3801 University, Montreal, PQ, Canada, H3A 2B4
N1 - Accession Number: 2005-09725-009. PMID: 2975043 Partial author list: First Author & Affiliation: Andreasen, Nancy C.; University of Iowa, Iowa City, IA, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neural Receptors; Schizophrenia; Striatum; Tomography. Minor Descriptor: Neurochemistry. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: 1988.
AB - Recently, two research groups published numbers for D₂ receptor sites in the neostriatum of drug-naive schizophrenic patients, obtained in vivo by positron emission tomography (PET). One study appeared to confirm the increase of D₂ receptor numbers, while the other study did not. A workshop was convened in Montreal to examine the reasons for the discrepancy between the results obtained by the two groups. The workshop considered patient populations, PET instrumentation and scanning methods, pharmacology, and modeling. The workshop identified differences between the approaches of the two groups that could contribute to the divergent results, including age and chronicity of the patient samples, brain region selected for study, metabolism of the different radioligands in blood and brain, reversibility of binding, PET instrumentation, and complexity of data analysis. The workshop concluded that these initial efforts had made considerable progress in establishing the role of PET in the understanding of the biochemical processes underlying mental illness. In particular, the unique ability to quantify regional neuroreceptor density at different stages in the evolution of the disease has been implemented. At the same time, the work so far and this conference served to identify the main sources contributing to the different findings from the two centers. This information will be important in designing the next phase of the research which will build upon and reconcile these apparent discrepancies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dopamine receptors
KW - schizophrenics
KW - tomography
KW - neostriatum
KW - 1988
KW - Dopamine
KW - Neural Receptors
KW - Schizophrenia
KW - Striatum
KW - Tomography
KW - Neurochemistry
KW - 1988
DO - 10.1093/schbul/14.3.471
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09725-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26896-009
AN - 2005-26896-009
AU - McGlashan, Thomas H.
AU - Carpenter, William T. Jr.
AU - Bartko, John J.
T1 - Issues of Design and Methodology in Long-Term Followup Studies.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 4
SP - 569
EP - 574
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - McGlashan, Thomas H., Chestnut Lodge Research Institute, 500 W. Montgomery Ave., Rockville, MD, US, 20850
N1 - Accession Number: 2005-26896-009. PMID: 3064283 Partial author list: First Author & Affiliation: McGlashan, Thomas H.; Chestnut Lodge Research Institute, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Design; Followup Studies; Longitudinal Studies; Methodology; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213); Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 6. Issue Publication Date: 1988.
AB - Beginning with Vaillant, followup studies of schizophrenia have devoted increasing attention to issues of design and methodology. The major advances and elements are described here and include: (1) conceptual framework, (2) design, (3) sample representativeness, (4) sample description, (5) data source and quality, (6) measures, (7) reliability, (8) diagnosis, (9) comparison groups, (10) assessment independence, (11) outcome, (12) missing subjects/bias testing, and (13) statistical techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - long-term followup studies
KW - design
KW - methodology
KW - schizophrenia
KW - 1988
KW - Experimental Design
KW - Followup Studies
KW - Longitudinal Studies
KW - Methodology
KW - Schizophrenia
KW - 1988
DO - 10.1093/schbul/14.4.569
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26896-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-26896-012
AN - 2005-26896-012
AU - Mirsky, Allan F.
AU - Quinn, Olive W.
T1 - The Genain Quadruplets.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1988///
VL - 14
IS - 4
SP - 595
EP - 612
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Mirsky, Allan F., Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bldg. 10, Rm. 4C-110, 9000 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2005-26896-012. PMID: 2905829 Partial author list: First Author & Affiliation: Mirsky, Allan F.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Oxford University Press. Release Date: 20090706. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Followup Studies; Genetics; Multiple Births; Schizophrenia; Severity (Disorders). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Aged (65 yrs & older) (380). Tests & Measures: Wechsler Abbreviated Scale of Intelligence DOI: 10.1037/t15170-000. References Available: Y. Page Count: 18. Issue Publication Date: 1988.
AB - The Genain quadruplets are a unique set of monozygous women who are concordant for schizophrenia but discordant for the severity of their disorder. They were studied by David Rosenthal and colleagues at the National Institute of Mental Health in the late 1950's when they were in their twenties and again in 1981 when they were 51. They are faring about as well now as they ever have in their adult lives. The results of psychological tests, some of which were repeated more than 20 years apart, are discussed, as are the effects of medication on attention and memory. The differential response of the Genains to neuroleptic drugs, as well as certain other findings in the 1981 study, leads to a different conclusion about the discordant severity of their disorder from that reached in 1963 by Rosenthal and Quinn. These observations emphasize the value of long-term followup studies in genetically related individuals, with repeated assessments of the same functions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Genain quadruplets
KW - monozygous women
KW - schizophrenia
KW - disorder severity
KW - long-term followup studies
KW - 1988
KW - Followup Studies
KW - Genetics
KW - Multiple Births
KW - Schizophrenia
KW - Severity (Disorders)
KW - 1988
DO - 10.1093/schbul/14.4.595
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-26896-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 119695992
T1 - Differences in platelet enzyme activity between alcoholics and nonalcoholics.
AU - Tabakoff, B
AU - Hoffman, P L
AU - Lee, J M
AU - Saito, T
AU - Willard, B
AU - De Leon-Jones, F
Y1 - 1988/01/21/
N1 - Accession Number: 119695992. Language: English. Entry Date: In Process. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Alcoholism
KW - Oxidoreductases -- Blood
KW - Fluorides
KW - Blood Platelets
KW - Human
KW - Adult
KW - Ethanol -- Pharmacodynamics
KW - Time Factors
KW - Population
KW - Metals -- Pharmacodynamics
KW - Smoking -- Blood
KW - Male
KW - Monoamine Oxidase Inhibitors -- Pharmacodynamics
KW - Cell Membrane
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 134
EP - 139
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 318
IS - 3
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - Blood platelets are an accessible tissue that reflects the activity of many enzymes found in the brain. To investigate the possible effect on such enzymes of long-term consumption of large quantities of ethanol, we assayed the activities of two enzymes, monoamine oxidase and adenylate cyclase, in platelet membranes of men with alcoholism and controls matched for sex and age. We also compared these two groups in terms of the inhibition of platelet monoamine oxidase activity by ethanol in vitro (400 mM), and in terms of the stimulation of adenylate cyclase activity by various agents. There was no significant difference in monoamine oxidase activity between the alcoholics and the controls. However, the inhibition of monoamine oxidase by ethanol was significantly higher in the platelets of alcoholics. The basal activity of adenylate cyclase was the same in platelets from the alcoholics and the controls, but the platelet adenylate cyclase activity after stimulation with guanine nucleotide, cesium fluoride, or prostaglandin E1 was significantly lower in alcoholics. These differences were not associated with age, race, smoking, or illicit drug use, and there was no significant correlation with the duration of problems with alcohol. The changes were long-lasting; cesium fluoride-stimulated adenylate cyclase activity was lower in alcoholic subjects who had abstained from alcohol for one to four years. Discriminant analysis showed that the use of values for the inhibition of monoamine oxidase activity by ethanol and cesium fluoride-stimulated adenylate cyclase activity correctly classified 75 percent of the alcoholics and 73 percent of the controls. These measures may be of value either as indexes of excessive alcohol consumption or as an indication of a predisposition to alcoholism.
SN - 0028-4793
AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md 20892
U2 - PMID: 3336400.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=119695992&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Looker, Anne C.
AU - Johnson, Clifford L.
AU - Woteki, Catherine E.
AU - Yetley, Elizabeth A.
AU - Underwood, Barbara A.
T1 - Ethnic and racial differences in serum vitamin A levels of children aged 4-11 years.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/02//
VL - 47
IS - 2
M3 - Article
SP - 247
EP - 252
SN - 00029165
AB - Interpretation of differences in serum vitamin A levels observed between Hispanic and non-Hispanic children may be complicated by confounding environmental factors. Data from the Mexican-American portion of the Hispanic Health and Nutrition Examination Survey and the second National Health and Nutrition Examination Survey were used to explore these differences in 4-11-y-old Mexican Americans and non-Hispanic blacks and whites before and after accounting for vitamin-mineral supplement use and poverty status. Initial differences in mean serum vitamin A levels and prevalences < 20 µg/dL (0.70 µmol/L) or < 25 µg/dL (0.87 µmol/L) among the three ethnic or racial groups were reduced or eliminated after accounting for the two descriptive variables. These results support the hypothesis that differences in serum vitamin A levels between Mexican-American and non-Hispanic children in the United States are due more to environmental factors than to ethnicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vitamin A
KW - Body fluids
KW - Blood plasma
KW - Serum
KW - Seroconversion
KW - Ethnic groups
KW - nutrition surveys
KW - vitamin A
N1 - Accession Number: 91710534; Looker, Anne C. 1; Johnson, Clifford L. 1; Woteki, Catherine E. 1; Yetley, Elizabeth A. 2; Underwood, Barbara A. 3; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville, MD; 2: Division of Nutrition, Food and Drug Administration, Washington, DC; 3: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Feb1988, Vol. 47 Issue 2, p247; Subject Term: Vitamin A; Subject Term: Body fluids; Subject Term: Blood plasma; Subject Term: Serum; Subject Term: Seroconversion; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: nutrition surveys; Author-Supplied Keyword: vitamin A; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=91710534&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boinski, S.
T1 - Use of a Club by a Wild White-Faced Capuchin (Cebus capucinus) To Attack a Venomous Snake (Bothrops asper).
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1988/02//
VL - 14
IS - 2
M3 - Article
SP - 177
EP - 179
SN - 02752565
AB - In Parque Nacional Manuel Antonio, Costa Rica, an adult male Cebus capucinus was observed repeatedly hitting a venomous snake (Bothrops asper) with a branch. Initially a large dead branch overhanging the snake had been broken off in the course of aggressive displays to the snake by the adult and two subadult males. The snake's escape was apparently prevented by the weight of the fallen branch and possibly by the injuries caused by its fall. This is the first direct observation of a capuchin monkey in a natural habitat using a tool. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAPUCHIN monkeys
KW - CAPUCHIN monkeys -- Behavior
KW - AGGRESSIVE behavior in animals
KW - BOTHROPS
KW - TOOL use in animals
KW - PREDATION (Biology)
KW - PRIMATES
KW - SNAKES
N1 - Accession Number: 12269671; Boinski, S. 1; Affiliation: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, National Institutes of Health; Source Info: 1988, Vol. 14 Issue 2, p177; Subject Term: CAPUCHIN monkeys; Subject Term: CAPUCHIN monkeys -- Behavior; Subject Term: AGGRESSIVE behavior in animals; Subject Term: BOTHROPS; Subject Term: TOOL use in animals; Subject Term: PREDATION (Biology); Subject Term: PRIMATES; Subject Term: SNAKES; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12269671&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bellantoni, Michele F.
AU - Blackman, Marc R.
T1 - Osteoporosis: Diagnostic screening and its place in current care.
JO - Geriatrics
JF - Geriatrics
Y1 - 1988/02//
VL - 43
IS - 2
M3 - Article
SP - 63
EP - 70
SN - 0016867X
N1 - Accession Number: 15839245; Bellantoni, Michele F. 1,2; Blackman, Marc R. 3,4; Source Information: Feb1988, Vol. 43 Issue 2, p63; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3639
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=15839245&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Malbran, A.
AU - Siwik, S.
AU - Frank, M. M.
AU - Fries, L. F.
T1 - CR1-receptor recycling in phorbol ester-activated polymorphonuclear leucocytes.
JO - Immunology
JF - Immunology
Y1 - 1988/02//
VL - 63
IS - 2
M3 - Article
SP - 325
EP - 330
PB - Wiley-Blackwell
SN - 00192805
AB - Complement-receptor type 1, CR1, which recognizes the C3b cleavage fragment of C3, is present on the membranes of human phagocytic cells, but does not mediate phagocytosis or undergo internalization unless activated by one of a variety of stimuli. Among these stimuli low doses of phorbol esters have been shown to induce a consistently increased expression of CR1, despite apparently continuous receptor internalization. We have studied the fate of internalized receptor-ligand complexes in neutrophils activated with low concentrations of phorbol dibutyrate. In our studies, we followed CR1 with either 125I-C3b, the physiologic ligand, or with 125I-Fab fragments oft monoclonal anti-CR1 antibody. We observed rapid internalization of CR1--C3b complexes by PMN treated with 10 ng/ml (1.98 × 10-8 M) PDBu, consistent in rate and extent with previously reported results using monoclonal antibodies. The fate of the internalized ligand was studied after elution of cell-surface C3b at 0°. Intracellular ligand was externalized in a time- and temperature-dependent fashion, reaching a plateau at 10-15 min. Released C3b was totally TCA precipitable and structurally unaltered, as determined by SDS-PAGE, suggesting that recycling occurs via a prelysosomal predegradative compartment. Loading the cells with chloroquine did not affect this process. A monoclonal anti-CR1 Fab probe behaved in exactly the same manner, suggesting that the recycling of intact ligand-receptor complexes takes place. The possible physiological consequences of this finding are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHAGOCYTOSIS
KW - BIOLOGICAL membranes
KW - IMMUNOGLOBULINS
KW - ANTIGEN-antibody reactions
KW - CELL receptors
KW - NEUTROPHILS
KW - ANTIMALARIALS
KW - LIGANDS (Biochemistry)
N1 - Accession Number: 14012679; Malbran, A. 1 Siwik, S. 1 Frank, M. M. 1 Fries, L. F. 1; Affiliation: 1: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb88, Vol. 63 Issue 2, p325; Subject Term: PHAGOCYTOSIS; Subject Term: BIOLOGICAL membranes; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGEN-antibody reactions; Subject Term: CELL receptors; Subject Term: NEUTROPHILS; Subject Term: ANTIMALARIALS; Subject Term: LIGANDS (Biochemistry); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rao, Shobini L.
T1 - Cognitive science and psycholinguistics.
JO - International Social Science Journal
JF - International Social Science Journal
Y1 - 1988/02//
VL - 40
IS - 115
M3 - Article
SP - 109
SN - 00208701
AB - This article focuses on cognitive science and psycholinguistics. Cognitive sciences are fields of enquiry devoted to the understanding of knowledge in a broad sense. The interlinkage of the fields of enquiry collectively described as the cognitive sciences is apparent. Cognition resembles a patterned carpet its separate colored threads being comparable to the different fields of enquiry. Psycholinguistics is an example of the intensive interchange of ideas between two fields leading to the emergence of a new field, this new field markedly hastening the scientific understanding of the common subject of enquiry, language. Language and thought or cognition are closely linked. The uniqueness of psycholinguistics lies in its appreciation of the psychological reality of the complexity of language, in terms of its rules of structure or grammar (Syntax) as well as in terms of its content or meaning (semantics). Psycholinguistics has made it possible to understand that language is largely a psychological process closely linked with knowledge. It emphasizes how language is a product of an individual's psychological processes, while linguistics concentrates on sharing language across individuals and cultures including discreteness, arbitrariness, openness and duality of patterning.
KW - COGNITIVE science
KW - PSYCHOLINGUISTICS
KW - PHILOSOPHY of mind
KW - LANGUAGE & languages
KW - SEMANTICS
KW - SYNTAX (Grammar)
N1 - Accession Number: 5710000; Rao, Shobini L. 1; Affiliation: 1: Lecturer, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India.; Source Info: Feb88, Vol. 40 Issue 115, p109; Subject Term: COGNITIVE science; Subject Term: PSYCHOLINGUISTICS; Subject Term: PHILOSOPHY of mind; Subject Term: LANGUAGE & languages; Subject Term: SEMANTICS; Subject Term: SYNTAX (Grammar); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martinet, Nadine
AU - Harne, Leslie A.
AU - Grotendorst, Gary R.
T1 - Identification and Characterization of Chemoattractants for Epidermal Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1988/02//
VL - 90
IS - 2
M3 - Article
SP - 122
EP - 126
SN - 0022202X
AB - We have detected and partially characterized factors that promote the directed migration of mouse epidermal cells in a modified Boyden chamber assay. Smooth muscle cells grown in culture were found to secrete a potent chemoattractant for epidermal cells. This activity was further characterized and compared to the chemotactic activities found in would fluid and conditioned medium from 3T3 L1 cells and with interleukin 1. The migration of epidermal cells during would healing in vivo might be regulated by such factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - MICE
KW - MUSCLES
KW - GROWTH factors
KW - CELL culture
KW - EPIDERMIS
N1 - Accession Number: 12462081; Martinet, Nadine 1 Harne, Leslie A. 1 Grotendorst, Gary R. 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Feb88, Vol. 90 Issue 2, p122; Subject Term: CELLS; Subject Term: MICE; Subject Term: MUSCLES; Subject Term: GROWTH factors; Subject Term: CELL culture; Subject Term: EPIDERMIS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12462081
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schooler, Carmi
T1 - Urban Japanese Housewives: At Home and in the Community (Book).
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1988/02//
VL - 50
IS - 1
M3 - Book Review
SP - 297
EP - 298
SN - 00222445
AB - Reviews the book "Urban Japanese Housewives: At Home and in the Community," by Anne E. Imamura.
KW - HOUSEWIVES
KW - NONFICTION
KW - IMAMURA, Anne E.
KW - URBAN Japanese Housewives: At Home & in the Community (Book)
N1 - Accession Number: 5272146; Schooler, Carmi 1; Affiliation: 1: National Institutes of Health; Source Info: Feb88, Vol. 50 Issue 1, p297; Subject Term: HOUSEWIVES; Subject Term: NONFICTION; Reviews & Products: URBAN Japanese Housewives: At Home & in the Community (Book); People: IMAMURA, Anne E.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fowler, B.
AU - Gould, E.
T1 - Ultrastructural and biochemical studies of intracellular metal-binding patterns in kidney tubule cells of the scallop Placopecten magellanicus following prolonged exposure to cadmium or copper.
JO - Marine Biology
JF - Marine Biology
Y1 - 1988/02//
VL - 97
IS - 2
M3 - Article
SP - 207
EP - 216
SN - 00253162
AB - Sea scallops Placopecten magellanicus, which had been trawl-collected in late November, 1982 off the Rhode Island, USA coast, were exposed to 20 μg of Cd or Cu per liter for a period of seven weeks in a flowing seawater system. Metal analyses of kidneys from both groups indicated uptake of both metals, although the tissue concentrations of Cd declined markedly in the Cu-treated scallops. The ultrastructural appearance of tubule cells of kidneys from Cd-exposed scallops was indistinguishable from controls. In contrast, tubule cells from scallops exposed to Cu showed marked cellular degeneration with loss of concretions. These ultrastructural changes were associated with significant reductions in renal isocitrate dehydrogenase activity in the Cu-treated scallops. Elemental analyses conducted on the kidney concretions and on the cytosolic metal-binding proteins of Cd-exposed scallops showed a 6-to 7-fold increase in Cd content of both these metalsequestering compartments, with concomitant changes in Zn, Mn, and Cu content. Loss of the concretions from Cu-treated scallops precluded analysis of this compartment, but Cu sequestration within cytosolic metal-binding proteins was associated with marked reductions of Zn and Cd from these proteins, suggesting disruption of this cellular mechanism for control of divalent metal cations. These findings support the hypothesis that toxic metal perturbation of normal homeostatic mechanisms that control divalent metal cation bioavailability is important factor in mediating cell injury from these agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Marine Biology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Scallops
KW - Copper
KW - Cadmium
KW - Cell death
KW - Placopecten magellanicus
KW - Rhode Island
N1 - Accession Number: 71122091; Fowler, B. 1; Gould, E. 2; Affiliations: 1: National Institute of Environmental Health Sciences, National Institutes of Health, 27709 Research Triangle Park USA; 2: National Marine Fisheries Service, Northeast Fisheries Center, Milford Laboratory, National Oceanic and Atmospheric Administration, 06460 Milford USA; Issue Info: 1988, Vol. 97 Issue 2, p207; Thesaurus Term: Scallops; Thesaurus Term: Copper; Thesaurus Term: Cadmium; Thesaurus Term: Cell death; Subject Term: Placopecten magellanicus; Subject: Rhode Island; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1007/BF00391304
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104753719
T1 - Reversible osmotic opening of the blood-brain barrier in mice.
AU - Fredericks, W R
AU - Rapoport, S I
Y1 - 1988/02//1988 Feb
N1 - Accession Number: 104753719. Language: English. Entry Date: 20110610. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266.
KW - Monosaccharides -- Pharmacokinetics
KW - Blood-Brain Barrier -- Drug Effects
KW - Animals
KW - Brain -- Anatomy and Histology
KW - Female
KW - Mice
KW - Osmosis -- Drug Effects
KW - Staining and Labeling
KW - Time Factors
SP - 266
EP - 268
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 19
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Unilateral reversible osmotic opening of the blood-brain barrier can be produced in mice. Infusion of 1.8 molal arabinose in water at a rate of 0.64 ml/min for 30 seconds into the internal carotid artery consistently results in ipsilateral brain staining by intravascular Evans blue dye. Osmotic opening is concentration-dependent (threshold, 1.6 molal arabinose) and reversible within 4 hours. No long-term neurologic deficit occurs. These results suggest that reversible osmotic blood-brain barrier opening can be applied to disease models in mice.
SN - 0039-2499
AD - Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
U2 - PMID: 2449747.
DO - 10.1161/01.STR.19.2.266
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-05457-015
AN - 2006-05457-015
AU - Jones, Barbara Pendleton
T1 - Updating for Clinical Neuropsychologists.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/02//
VL - 33
IS - 2
SP - 123
EP - 124
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05457-015. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Jones, Barbara Pendleton; Laboratory of Psychology and Psychopathohgy, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Nervous System Disorders; Neuropsychological Assessment; Neuropsychology; Psychiatrists. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Reviewed Item: Grant, Igor (Ed); Adams, Kenneth M. (Ed). Neuropsychological Assessment of Neuropsychiatric Disorders=New York: Oxford University Press, 1986. 536 pp. $45.00; 1986. References Available: Y. Page Count: 2. Issue Publication Date: Feb, 1988.
AB - Reviews the book, Neuropsychological Assessment of Neuropsychiatric Disorders edited by Igor Grant and Kenneth M. Adams (1986). This volume deserves a prominent position in the growing collection of works on clinical neuropsychology. It begins with a five-chapter section on methods of neuropsychological assessment, and both in this section and throughout, there is a commendable representation of most of the major approaches in this somewhat faction-ridden field. Overall, this book provides a welcome updating of knowledge in critical areas for clinical neuropsychologists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical neuropsychologists
KW - neuropsychological assessment
KW - neuropsychiatric disorders
KW - 1988
KW - Nervous System Disorders
KW - Neuropsychological Assessment
KW - Neuropsychology
KW - Psychiatrists
KW - 1988
U2 - Grant, Igor (Ed); Adams, Kenneth M. (Ed). (1986); Neuropsychological Assessment of Neuropsychiatric Disorders; New York: Oxford University Press, 1986. 536 pp. $45.00; 0-19-503545-3.
DO - 10.1037/025390
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Patterson, Blossom H.
AU - Block, Gladys
T1 - Food Choices and the Cancer Guidelines.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/03//
VL - 78
IS - 3
M3 - Article
SP - 282
EP - 286
PB - American Public Health Association
SN - 00900036
AB - Abstract: Twenty-four hour dietary recall data from 11,658 adult respondents in the second National Health and Nutrition Examination Survey (NHANES II) (1976-80) were used to examine the American diet in relation to certain of the cancer dietary guidelines from the National Academy of Sciences and the American Cancer Society. The per ¢ who reported consuming any food in those food groups considered protective was small: cruciferous vegetables (18 per ¢); fruits and vegetables high in vitamin A (21 per ¢); high fiber breads and cereals (16 per ¢). The per ¢ consuming foods potentially increasing cancer risk was high: red meat (55 per ¢); bacon and lunch meats (43 per ¢). Proportions of persons eating fruits and vegetables increased with income. Diets were closer to the guidelines for females than males, for Blacks than Whites, and for older than younger Americans. INSET: Nominations Invited for 1988 International Health Section.... [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys -- Statistical methods
KW - HEALTH & Nutrition Examination Survey
KW - DIET
KW - NUTRITION
KW - CANCER -- Risk factors
KW - FOOD consumption
KW - UNITED States
KW - NATIONAL Academy of Sciences (U.S.)
KW - AMERICAN Cancer Society Inc.
N1 - Accession Number: 4685087; Patterson, Blossom H. 1 Block, Gladys 1; Affiliation: 1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Mar88, Vol. 78 Issue 3, p282; Subject Term: HEALTH surveys -- Statistical methods; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: DIET; Subject Term: NUTRITION; Subject Term: CANCER -- Risk factors; Subject Term: FOOD consumption; Subject Term: UNITED States; Company/Entity: NATIONAL Academy of Sciences (U.S.) Company/Entity: AMERICAN Cancer Society Inc.; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Uphoff, Delta E.
AU - Uphoff, Delta
T1 - SOME THINGS LAMARCKIAN.
JO - BioScience
JF - BioScience
Y1 - 1988/03//
VL - 38
IS - 3
M3 - Letter
SP - 144
EP - 144
SN - 00063568
AB - Presents a letter to the editor in response to the article "Mythology in introductory biology," in BioScience 37: 611-614.
KW - Letters to the editor
KW - Mythology
N1 - Accession Number: 10109020; Uphoff, Delta E. 1; Uphoff, Delta; Affiliations: 1: Research Biologist, National Cancer Institute, Bethesda, MD 20892; Issue Info: Mar1988, Vol. 38 Issue 3, p144; Subject Term: Letters to the editor; Subject Term: Mythology; Number of Pages: 1/2p; Document Type: Letter; Full Text Word Count: 461
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Abbotts, John
T1 - MENTORS AND APPRENTICES.
JO - BioScience
JF - BioScience
Y1 - 1988/03//
VL - 38
IS - 3
M3 - Book Review
SP - 184
EP - 184
SN - 00063568
AB - Reviews the book "Apprentice to Genius: The Making of a Scientific Dynasty," by Robert Kanigel.
KW - Mentoring in science
KW - Nonfiction
KW - Kanigel, Robert
KW - Apprentice to Genius (Book)
N1 - Accession Number: 10120919; Abbotts, John 1; Affiliations: 1: Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892; Issue Info: Mar1988, Vol. 38 Issue 3, p184; Subject Term: Mentoring in science; Subject Term: Nonfiction; Reviews & Products: Apprentice to Genius (Book); People: Kanigel, Robert; Number of Pages: 8/9p; Illustrations: 1 Cartoon or Caricature; Document Type: Book Review; Full Text Word Count: 842
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Nutt, David
AU - Costello, Michael
T1 - Lithium and Psoriasis: Is 5-HT the Connection?
JO - Human Psychopharmacology: Clinical & Experimental
JF - Human Psychopharmacology: Clinical & Experimental
Y1 - 1988/03//
VL - 3
IS - 1
M3 - Letter
SP - 67
EP - 68
PB - John Wiley & Sons, Inc.
SN - 08856222
AB - Presents a letter to the editor about treatment of psoriasis with lithium salts, published in the March 1988 issue of the journal "Human Psychopharmacology."
KW - LETTERS to the editor
KW - PSORIASIS
N1 - Accession Number: 12371603; Nutt, David 1 Costello, Michael 2; Affiliation: 1: Laboratory of Clinical Science, National Institute on Alcohol Abuse and Alcoholism. 2: National Institutes of Health, Building 10/3 B19, 9000 Rockville Pike, Bethesda, MD 20892, USA.; Source Info: Mar88, Vol. 3 Issue 1, p67; Subject Term: LETTERS to the editor; Subject Term: PSORIASIS; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Jong, Judith A.
AU - Donovan, Donna Coghlan
T1 - Age-Related Differences in Beliefs, Attitudes and Practices of Priests.
JO - Journal for the Scientific Study of Religion
JF - Journal for the Scientific Study of Religion
Y1 - 1988/03//
VL - 27
IS - 1
M3 - Article
SP - 128
EP - 136
PB - Wiley-Blackwell
SN - 00218294
AB - The article deals with a study which examined the relationship between age, basis of belief, attitude toward religious experience, and frequency of religious practices among Catholic diocesan priests in the United States. The sample consisted of 1027 diocesan priests in the continental United States who completed the Spiritual Orientation Inventory (SOI) upon entrance of their diocese in the Ministry to Priests Program (MPP). For study purposes, subjects were divided into 4 age groups. As a first step in participation of their diocese in the MPP, the SOT was administered to the priests, along with other psychological instruments, in group sessions in their home diocess. Later, at a retreat, the priests privately received feedback from a trained associate who discussed with them the results of their tests. The results of all the instruments were strictly confidential. This study, found age associated with a higher level of certainty. Older priests expressed less doubt about the existence of God and tended toward reliance on logic more and on experience less, than the other groups. The youngest priests found God most naturally through people and events; older groups tended more toward finding God through reading Scripture or other writings and formal worship. Older priests had fewer transcendent experiences and less trust in dreams and imagination than did the younger priests.
KW - RELIGIOUS psychology
KW - ATTITUDE (Psychology)
KW - CLERGY
KW - BELIEF & doubt
KW - THEORY of knowledge
KW - RELIGION
KW - CATHOLIC Church
KW - CATHOLIC Church -- Clergy
N1 - Accession Number: 4903295; De Jong, Judith A. 1 Donovan, Donna Coghlan; Affiliation: 1: Staff fellow at the National Institutes of Health (NIH), Bethesda, Maryland; Source Info: Mar88, Vol. 27 Issue 1, p128; Subject Term: RELIGIOUS psychology; Subject Term: ATTITUDE (Psychology); Subject Term: CLERGY; Subject Term: BELIEF & doubt; Subject Term: THEORY of knowledge; Subject Term: RELIGION; Subject Term: CATHOLIC Church; Company/Entity: CATHOLIC Church -- Clergy; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Donald M.
AU - Toni Po-On Cheng, Donald M.
T1 - INTRACELLULAR LOCALIZATION OF SAXITOXINIS IN THE DINOFLAGELLATE GONYAULAX TAMARENSIS.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1988/03//
VL - 24
IS - 1
M3 - Article
SP - 17
EP - 22
PB - Wiley-Blackwell
SN - 00223646
AB - The potent neurotoxin saxitoxin, and possibly several of its derivatives, are localized in two types of sites within the marine dinoflagellate Gonyaulax tamarensis Lehour. Immunocytochemical techniques using a polydonal antibody and epifluorescence microscopy demonstrate toxin localization within the nucleus as well as on the periphery of small granules thought to be starch grains. In the nuclear region, the labelling occurred on or close to the permanently-condensed chromosomes as well as in an area within the two arms of the nucleus in the vicinity of the nucleolus. No binding was observed in a closely-related, non-toxic dinoflagellate. Different binding affinites were observed between the nucleus and the grains at high and low antibody dilutions. This may relate to the polyclonal nature of the antiserum and to the presence off multiple toxius within the G. tamarensis isolate studied. Mechanistic interpretations of these labelling patterns remain speculative, especially the localization of the antigen at the outer edge off starch grains, but the distinct labelling in the nuclear region suggests that saxitoxin, with its two positively charged guanidinium groups, may bind to nucleic acids or nuclear proteins in a manner analogous to the polyamines and other cations. The labelling patterns reported here suggest that the saxitoxins may not simply be secondary metabolites but instead could be important compounds involved in the structure and function of the G. tamarensis genome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Saxitoxin
KW - Neurotoxic agents
KW - Dinoflagellates
KW - Alexandrium tamarense
KW - Microscopy
KW - Chromosomes
KW - antibody
KW - dinoflagellate
KW - Gonyaulax tamarensis
KW - immunocytochemistry
KW - immunofluorescence
KW - saxitoxin
N1 - Accession Number: 10986764; Anderson, Donald M. 1; Toni Po-On Cheng, Donald M. 2; Affiliations: 1: Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543; 2: Laboratory of Neurobiology, National Institute of Neurological Communicative Disease and Stroke National Institutes of Health at the Marine Biological Laboratory, Woods Hole, Massachusetts 02543; Issue Info: Mar1988, Vol. 24 Issue 1, p17; Thesaurus Term: Saxitoxin; Thesaurus Term: Neurotoxic agents; Thesaurus Term: Dinoflagellates; Subject Term: Alexandrium tamarense; Subject Term: Microscopy; Subject Term: Chromosomes; Author-Supplied Keyword: antibody; Author-Supplied Keyword: dinoflagellate; Author-Supplied Keyword: Gonyaulax tamarensis; Author-Supplied Keyword: immunocytochemistry; Author-Supplied Keyword: immunofluorescence; Author-Supplied Keyword: saxitoxin; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1529-8817.ep10986764
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baker, Stuart G.
AU - Laird, Nan M.
T1 - Regression Analysis for Categorical Variables With Outcome Subject to Nonignorable Nonresponse.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1988/03//
VL - 83
IS - 401
M3 - Article
SP - 62
SN - 01621459
AB - We develop a log-linear model for categorical response subject to nonignorable nonresponse. The paper differs from Fay (1986) in its focus on estimation and hypothesis testing in a regression setting, as opposed to imputation in a multivariate setting. We present several new results concerning the existence of solutions on the boundary of the parameter space and the construction of confidence intervals for estimates. We illustrate the method by estimating the proportion of voters preferring Truman in a 1948 preelection poll (Mosteller, Hyman, McCarthy, Marks, and Truman 1949). Results may depend strongly on the model assumed for nonresponse; goodness-of-fit tests are available for comparing alternative models. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - STATISTICAL hypothesis testing
KW - MULTIVARIATE analysis
KW - MATHEMATICAL models
KW - LOG-linear models
KW - CONFIDENCE intervals
KW - HYPOTHESIS
KW - EM algorithm
KW - Missing data.
KW - Sample survey
N1 - Accession Number: 4609860; Baker, Stuart G. 1; Laird, Nan M. 2; Affiliations: 1: Staff Fellow, Biometry Branch, Division of Cancer Prevention and Control, National Institutes of Health (NIH), Bethesda, MD 20892-4200.; 2: Professor of Biostatistics, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.; Issue Info: Mar1988, Vol. 83 Issue 401, p62; Thesaurus Term: REGRESSION analysis; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: MATHEMATICAL models; Subject Term: LOG-linear models; Subject Term: CONFIDENCE intervals; Subject Term: HYPOTHESIS; Author-Supplied Keyword: EM algorithm; Author-Supplied Keyword: Missing data.; Author-Supplied Keyword: Sample survey; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Jasiukaitis, Paul
AU - Hakerem, Gad
T1 - The Effect of Prestimulus Alpha Activity on the P300.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1988/03//
VL - 25
IS - 2
M3 - Article
SP - 157
EP - 165
SN - 00485772
AB - Trials on which highly discrepant, auditory `oddball' stimuli were presented were sorted into two bins on the basis of prestimulus alpha band RMS magnitude. The trial bins were then separately averaged to produce a `high alpha' auditory ERP (event-related potential) and a `low alpha' ERP for each subject. Study 1 found that larger amplitude P300s were obtained in the `high alpha' ERP. No effect of alpha was found on the N 100. Study 2 employed extra factors of stimulus intensity change (increases and decreases) and alpha measurement period (before and after the `oddball' stimulus). It was found that P300 amplitude enhancement was independent of both stimulus intensity and the amount of alpha poststimulus. The data are discussed in terms of cascaded inhibition from the mesencephalic reticutar formation to nucleus reticularis of the thalamus to a thalamo-cortical system responsible for the generation of both alpha and the P300. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVOKED potentials (Electrophysiology)
KW - BRAIN
KW - PSYCHOPHYSIOLOGY
KW - Alpha activity
KW - Event-related potentials (ERPs)
KW - Neuronal inhibition and rebound.
KW - P300 component
N1 - Accession Number: 11027166; Jasiukaitis, Paul 1 Hakerem, Gad 2; Affiliation: 1: Laboratory of Psychology and Psychopathology, National Institute of Mental Health. 2: Department of Psychology, Queens College, City University of New York.; Source Info: Mar1988, Vol. 25 Issue 2, p157; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: BRAIN; Subject Term: PSYCHOPHYSIOLOGY; Author-Supplied Keyword: Alpha activity; Author-Supplied Keyword: Event-related potentials (ERPs); Author-Supplied Keyword: Neuronal inhibition and rebound.; Author-Supplied Keyword: P300 component; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1469-8986.ep11027166
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11027166&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lang, W. Robert
AU - Snyder, Frederick R.
AU - Lozovsky, David
AU - Kaistha, Vivek
AU - Kaczaniuk, Mary A.
AU - Jaffe, Jerome H.
T1 - Geographic Distribution of Human Immunodeficiency Virus Markers in Parental Drug Abusers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/04//
VL - 78
IS - 4
M3 - Editorial
SP - 443
EP - 446
PB - American Public Health Association
SN - 00900036
AB - Drug abuse treatment programs in six regions of the United States collaborated in a study aimed at monitoring trends in the seroprevalence of human immunodeficiency virus (HIV) antibodies. The wide disparities in HIV seroprevalence in the face of similarities in drug using behavior have important implications for prevention. In the New York City area (Harlem, Brooklyn), 61 per cent; of samples (N=280) obtained in late 1986 were positive, up from 50 per cent; of samples (N=585) in early 1985. In Baltimore, Maryland, 29 per cent; of samples (N = 184) representing 11 programs were positive. In contrast, samples from programs distant from the Northeast corridor had far lower rates: Denver, Colorado 5 per cent; (N=100); San Antonio, Texas 2 per cent; (N=106); Southern California, 1.5 per cent; (N=413); and Tampa, Florida, 0 per cent; (N=102). Contrary to expectations, there was no corresponding difference in reported lifetime needle sharing experiences, which ranged from 70 per cent; in New York to 99 per cent; in San Antonio. HIV seropositivity was associated only with geographic location and ethnicity; however, because needle sharing is practiced by parenteral drug abusers in areas where seroprevalence is still relatively low, these areas are potentially vulnerable to the same catastrophic spread seen in the Northeast. A window of opportunity exists where prompt, vigorous, and aggressive efforts at prevention could have major impact. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - SUBSTANCE abuse
KW - HIV antibodies
KW - VIRAL antibodies
KW - HIV (Viruses)
KW - HIV infections
KW - MEDICAL care
KW - COMMUNITY health services
KW - UNITED States
N1 - Accession Number: 4687436; Lang, W. Robert 1 Snyder, Frederick R. 1 Lozovsky, David 1 Kaistha, Vivek 1 Kaczaniuk, Mary A. 1 Jaffe, Jerome H. 1; Affiliation: 1: Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland; Source Info: Apr88, Vol. 78 Issue 4, p443; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: HIV antibodies; Subject Term: VIRAL antibodies; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: COMMUNITY health services; Subject Term: UNITED States; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kingman, Albert
AU - Little, Wayne
AU - Gomez, Irma
AU - Heitetz, Stanley B.
AU - Driscoll, William S.
AU - Sheats, Rose
AU - Supan, Paul
T1 - Salivary levels of Streptococcus mutans and lactobacilli and dental caries experiences in a US adolescent population.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1988/04//
VL - 16
IS - 2
M3 - Article
SP - 98
EP - 103
SN - 03015661
AB - Dental caries exams and saliva samples were obtained from 541 adolescents, aged 10-15. initially and after 17 months as pan of a 3-yr longitudinal study investigating the relationships of dietary intakes, specific microorganisms in saliva, and the prevalence and incidence of dental caries. The mean DMFS score detected in these subjects initially was 4.61, and they developed an average of 1.38 new DMFS during the first 17-month period. Initially, S. mutans and lactobacilli were detected in 64% and 56% of these subjects, respectively. Subjects with low levels of S. mutans and lactobacilli had significantly lower initial DMFS scores and developed significantly fewer new DMES than subjects with high counts. The predictive values of a positive result for S. mutans or lactobacilli assays were low (31 % and 39%), but those for a negative result were high (81% and 84%). [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALIVA
KW - STREPTOCOCCUS mutans
KW - STREPTOCOCCUS
KW - LACTOBACILLUS
KW - DENTAL caries
KW - DENTAL pathology
KW - TEENAGERS
KW - UNITED States
KW - caries incidence
KW - caries prevalence
KW - lactobacilli
KW - S. mutans
N1 - Accession Number: 12015316; Kingman, Albert 1 Little, Wayne 1 Gomez, Irma 1 Heitetz, Stanley B. 1 Driscoll, William S. 1 Sheats, Rose 1 Supan, Paul 1; Affiliation: 1: Epidemiology and Oral Diseases Prevention Program, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.; Source Info: Apr1988, Vol. 16 Issue 2, p98; Subject Term: SALIVA; Subject Term: STREPTOCOCCUS mutans; Subject Term: STREPTOCOCCUS; Subject Term: LACTOBACILLUS; Subject Term: DENTAL caries; Subject Term: DENTAL pathology; Subject Term: TEENAGERS; Subject Term: UNITED States; Author-Supplied Keyword: caries incidence; Author-Supplied Keyword: caries prevalence; Author-Supplied Keyword: lactobacilli; Author-Supplied Keyword: S. mutans; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12015316
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-05459-060
AN - 2006-05459-060
AU - Optican, Lance M.
T1 - Understanding movement: Oculomotor progress and skeletalmotor confusion.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/04//
VL - 33
IS - 4
SP - 366
EP - 367
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05459-060. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Optican, Lance M.; Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Eye Movements; Motor Processes. Minor Descriptor: Brain. Classification: Physiological Processes (2540). Population: Human (10). Reviewed Item: Freund, H. -J. (Ed); Büttner, U. (Ed); Cohen, B. (Ed); Noth, J. (Ed). The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64=Amsterdam: Elsevier, 1986. 432 pp. $118.50 (Dfl. 320,-); 1986. Page Count: 2. Issue Publication Date: Apr, 1988.
AB - Reviews the book, The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64 edited by H.-J. Freund, U. Büttner, B. Cohen, and J. Noth (1986). The content of this book, a volume in the 'Progress in Brain Research' series is based on a symposium held in 1984 to bring together researchers from the fields of eye and body movements to discuss similarities and differences in their respective systems The editors state in the preface that 'a comparison of this kind was meant to stimulate new approaches based on cooperative aspects rather than to provide an update about the state of the art in either field.' To a certain extent, that intent was achieved; the book is not up to date with regard to research in those fields. In particular, the rapid progress in mathematical models of oculomotor control was not represented. It seems safe to say that one of the dominant forces in oculomotor studies in the past 10 or 15 years has been the progress in models accurate enough to simulate eye movements and provide predictions about the control of movement. The absence of a section on modeling makes the book even more dated than it might otherwise appear. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oculomotor systems
KW - skeletalmotor systems
KW - brain research
KW - 1988
KW - Eye Movements
KW - Motor Processes
KW - Brain
KW - 1988
U2 - Freund, H. -J. (Ed); Büttner, U. (Ed); Cohen, B. (Ed); Noth, J. (Ed). (1986); The Oculomotor and Skeletalmotor Systems: Differences and Similarities, Vol. 64; Amsterdam: Elsevier, 1986. 432 pp. $118.50 (Dfl. 320,-); 0-444-80655-5.
DO - 10.1037/025636
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Davis, Michael D.
AU - Kaufman, Seymour
AU - Milstien, Sheldon
T1 - The auto-oxidation of tetrahydrobiopterin.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/04/15/
VL - 173
IS - 2
M3 - Article
SP - 345
EP - 351
PB - Wiley-Blackwell
SN - 00142956
AB - The product of the aerobic oxidation of tetrahydrobiopterin, quinonoid dihydrobiopterin, is unstable and rapidly rearranges to form a 7,8-dihydropteridine. Kaufman [Kaufman, S. (1967) J. Biol. Chem. 242, 3934–3943] identified tee stable product produced in 0.1 M phosphate pH 6.8, as 7,8-dihydrobiopterin. However, Armarego et al. [Armasego, W. L. F., Raadles, D. and Taguchi, H. (1983) Eur. J. Biochem. 155 393–403] questioned this assignment because they found that the dihydroxypropyl group on C-6 was eliminated and 7,8-dihydropterin was the predominant product when the aerobic oxidation was performed in 0.1 M Tris pH 7.6. In the present study we demonstrate that the rearrangement of the unstable quinonoid dihydrobiopterin results in a mixture of these two 7,8-dihydropteridines at neutral pH, 25°C. Furthermore, we find that the loss or retention of the alkyl side. chain is not solely dependent on the pH of the reaction mixture, as was previously assumed by Armarego et al., but rather is strongly influenced by the temperature and the type of buffer. In additton, we describe a new method for quantifying the relative amounts of these two 7,8-dihydropteridines in mixtures of unknown concentrations. This method relies on multicomponent analysis of second derivative spectra and results in values which agree with the concentrations determined directly by HPLC. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATION
KW - TETRAHYDROBIOPTERIN
KW - ENZYMES -- Analysis
KW - COENZYMES
KW - TEMPERATURE
KW - NEUROCHEMISTRY
N1 - Accession Number: 14317086; Davis, Michael D. 1 Kaufman, Seymour 1 Milstien, Sheldon 1; Affiliation: 1: Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland; Source Info: 4/15/88, Vol. 173 Issue 2, p345; Subject Term: OXIDATION; Subject Term: TETRAHYDROBIOPTERIN; Subject Term: ENZYMES -- Analysis; Subject Term: COENZYMES; Subject Term: TEMPERATURE; Subject Term: NEUROCHEMISTRY; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feigl, Polly
AU - Glaefke, Gwen
AU - Ford, Leslie
AU - Diehr, Paula
AU - Chu, Joe
T1 - Studying Patterns of Cancer Care: How Useful is the Medical Record?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 526
EP - 533
PB - American Public Health Association
SN - 00900036
AB - Records of hospital inpatients were abstracted for 5,000 newly diagnosed cancer patients admitted in 1982-83 to 17 Comprehensive Cancer Centers and 17 Community Hospital Oncology Programs. Generally available data items (silent record rate less than 5 per cent for the typical institution) included: age, race, sex, dates of hospitalization, zip code of residence, pathological stage, dates of biopsy and surgery, numbers of nodes examined and positive, certain diagnostic procedures, and some radiotherapy descriptors. For other data items, there was enormous variability in completeness and high institution-to-institution variation. Record completeness did not differ consistently between comprehensive and community cancer centers. We conclude that the hospital patient record is useful for tracking the frequency of surgical and related events. However, studies of diagnostic and therapeutic procedures should not rely solely on the hospital medical record due to the high rates of silent records. INSET: Medical Literature at Risk of Deterioration from Acid in Paper. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL records
KW - CANCER patients
KW - MEDICAL care
KW - COMMUNITY centers
KW - ONCOLOGY nursing
KW - ONCOLOGIC surgery
KW - CANCER
KW - CANCER -- Diagnosis
KW - RADIOTHERAPY
KW - HOSPITAL records
KW - PATHOPHYSIOLOGY
N1 - Accession Number: 4686931; Feigl, Polly 1 Glaefke, Gwen 1 Ford, Leslie 2 Diehr, Paula 1 Chu, Joe 1; Affiliation: 1: Fred Hutchinson Research Center. 2: National Cancer Institute, Division of Cancer Prevention and Control.; Source Info: May88, Vol. 78 Issue 5, p526; Subject Term: MEDICAL records; Subject Term: CANCER patients; Subject Term: MEDICAL care; Subject Term: COMMUNITY centers; Subject Term: ONCOLOGY nursing; Subject Term: ONCOLOGIC surgery; Subject Term: CANCER; Subject Term: CANCER -- Diagnosis; Subject Term: RADIOTHERAPY; Subject Term: HOSPITAL records; Subject Term: PATHOPHYSIOLOGY; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Freimuth, Vicki S.
AU - Hammond, Sharon L.
AU - Stein, Judith A.
T1 - Health Advertising: Prevention for Profit.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 557
EP - 561
PB - American Public Health Association
SN - 00900036
AB - The National Cancer Institute (NCI) estimates on the basis of current knowledge alone that, at a minimum, 30,000 lives could be saved in the year 2000 if Americans would modify their dietary habits. A recent innovative way of responding to this challenge was the Kellogg Company/NCI All-Bran advertising campaign. This paper will describe the campaign, and its impact on consumers, cereal industry sales, food industry advertising practices, health regulatory policy, and the organizational credibility of both NCI and Kellogg. For the past three years, Kellogg has included NCI's cancer prevention messages in their advertisements for All-Bran cereal and on their bran cereal boxes. This collaborative effort has stimulated considerable controversy over whether the health claims made on the cereal label are in violation of federal food labeling regulations. Meanwhile, research has demonstrated the positive impact of the campaign on consumer's knowledge and behavior regarding fiber as well as on Kellogg's profits. Other manufacturers are anxious to jump on the "branwagon"; however, many unanswered questions remain about this new approach to health advertising. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - ADVERTISING campaigns
KW - ADVERTISING -- Health products
KW - MEDICAL policy
KW - FOOD labeling -- Law & legislation
KW - CONSUMER behavior
KW - PRODUCT acceptance
KW - CEREAL products industry
KW - FOOD industry
KW - UNITED States
KW - KELLOGG Co.
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 4687122; Freimuth, Vicki S. 1 Hammond, Sharon L. 1 Stein, Judith A. 2; Affiliation: 1: Department of Communication Arts and Theatre, University of Maryland, College Park, MD 20742. 2: National Eye Institute, Bethesda, MD 20892.; Source Info: May88, Vol. 78 Issue 5, p557; Subject Term: HEALTH promotion; Subject Term: ADVERTISING campaigns; Subject Term: ADVERTISING -- Health products; Subject Term: MEDICAL policy; Subject Term: FOOD labeling -- Law & legislation; Subject Term: CONSUMER behavior; Subject Term: PRODUCT acceptance; Subject Term: CEREAL products industry; Subject Term: FOOD industry; Subject Term: UNITED States; Company/Entity: KELLOGG Co. DUNS Number: 080600430 Ticker: K Company/Entity: NATIONAL Cancer Institute (U.S.) DUNS Number: Ticker: ; NAICS/Industry Codes: 541870 Advertising Material Distribution Services; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hasin, Deborah S.
AU - Grant, Bridget F.
AU - Endicott, Jean
AU - Harford, Thomas C.
T1 - Cocaine and Heroin Dependence Compared in Poly-Drug Abusers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 567
EP - 569
PB - American Public Health Association
SN - 00900036
AB - Concerns about cocaine dependence are increasing, in some ways replacing heroin as the focus of highest concern. We compared cocaine and heroin dependence by levels of cocaine and heroin use in poly-drug users. While dependence indicators differed markedly between regular and sporadic users of these drugs, cocaine dependence indicators did not differ from heroin dependence indicators. Implications of the findings are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCAINE abuse
KW - HEROIN abuse
KW - DRUG abuse
KW - SUBSTANCE abuse
KW - ALCOHOLISM
KW - MEDICAL statistics
KW - UNITED States
KW - AMERICAN Psychiatric Association
KW - DIAGNOSTIC & Statistical Manual (Book)
N1 - Accession Number: 4687152; Hasin, Deborah S. 1,2 Grant, Bridget F. 3 Endicott, Jean 4 Harford, Thomas C. 3; Affiliation: 1: Research Scientist, New York State psychiatric Institute, 722 West 168th Street, Box 123, New York, NY 10032. 2: Assistant Professor , Department of Epidemiology, School of Public Health, Columbia University. 3: National Institute on Alcohol Abuse and Alcoholism. 4: Columbia University and NYS Psychiatric Institute.; Source Info: May88, Vol. 78 Issue 5, p567; Subject Term: COCAINE abuse; Subject Term: HEROIN abuse; Subject Term: DRUG abuse; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOLISM; Subject Term: MEDICAL statistics; Subject Term: UNITED States; Company/Entity: AMERICAN Psychiatric Association DUNS Number: 020292348; Reviews & Products: DIAGNOSTIC & Statistical Manual (Book); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cantor, Kenneth P.
AU - Blair, Aaron
AU - Everett, George
AU - VanLier, Stephanie
AU - Burmeister, Leon
AU - Dick, Fred R.
AU - Gibson, Robert W.
AU - Schuman, Leonard
T1 - Hair Dye Use and Risk of Leukemia and Lymphoma.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 570
EP - 571
PB - American Public Health Association
SN - 00900036
AB - Data from a population-based case-control study of incident leukemia and non-Hodgkin's lymphoma among adult men in Iowa and Minnesota were used to evaluate risk associated with hair dye use. The relative risk for ever using hair dyes was 1.8 (95% confidence interval [CI] = 1.1-2.7) among leukemia patients, and 2.0 (CI = 1.3-3.0) among cases with non-Hodgkin's lymphoma. There was a suggestion of increased risk with extent of hair dye use. Given the widespread use of hair coloring products, these observations deserve more detailed evaluation in populations where the exposure is relatively common. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAIR -- Dyeing & bleaching
KW - HAIR care products
KW - LEUKEMIA
KW - LYMPHOMAS
KW - RETICULO-endothelial system -- Tumors
KW - MEN -- Health
KW - MEDICAL statistics
KW - HEALTH surveys -- United States
KW - UNITED States
N1 - Accession Number: 4687162; Cantor, Kenneth P. 1 Blair, Aaron 1 Everett, George 2 VanLier, Stephanie 2 Burmeister, Leon 2 Dick, Fred R. 2 Gibson, Robert W. 3 Schuman, Leonard 3; Affiliation: 1: National Cancer Institute, Environmental Epidemiology Branch. 2: University of Iowa College of Medicine. 3: University of Minnesota School of Public Health.; Source Info: May88, Vol. 78 Issue 5, p570; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: HAIR care products; Subject Term: LEUKEMIA; Subject Term: LYMPHOMAS; Subject Term: RETICULO-endothelial system -- Tumors; Subject Term: MEN -- Health; Subject Term: MEDICAL statistics; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kahn, Joan R.
AU - Kalsbeek, William D.
AU - Hofferth, Sandra L.
T1 - National Estimates of Teenage Sexual Activity: Evaluating the Comparability of Three National Surveys.
JO - Demography
JF - Demography
Y1 - 1988/05//
VL - 25
IS - 2
M3 - Article
SP - 189
EP - 204
SN - 00703370
AB - In this article, we examine the reliability with which teenage sexual activity was reported in three recent national surveys. Unlike other study-effects analyses of objective demographic phenomena such as births and marriages, ours focuses on a more sensitive question-age at first intercourse as reported in three very different surveys. Specifically, we compare reports for the 1959-1963 cohort in the 1979 Kantner-Zelnik Study of Young Women, the 1982 National Survey of Family Growth, and the 1983 wave of the National Longitudinal Survey of Youth. For the ages when the majority of teens become sexually active (16-19), the three surveys provide comparable estimates of early sexual activity. For the younger teen ages, however, there is some disagreement among the estimates. Nevertheless, all three studies produce consistent estimates of the determinants of sexual activity throughout the teen years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEMOGRAPHY
KW - TEENAGERS -- Sexual behavior
KW - SOCIAL surveys
KW - MARRIAGE
KW - YOUNG women
KW - AGE groups
KW - EPHEMERA—PERSONAL NARRATIVES
N1 - Accession Number: 16799665; Kahn, Joan R. 1; Kalsbeek, William D. 2; Hofferth, Sandra L. 3; Affiliations: 1: Department of Sociology, University of Maryland, College Park, Maryland 20742.; 2: Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27514.; 3: Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute for Child Health and Human Development, Bethesda, Maryland 20892.; Issue Info: May1988, Vol. 25 Issue 2, p189; Thesaurus Term: DEMOGRAPHY; Subject Term: TEENAGERS -- Sexual behavior; Subject Term: SOCIAL surveys; Subject Term: MARRIAGE; Subject Term: YOUNG women; Subject Term: AGE groups; Author-Supplied Keyword: EPHEMERA—PERSONAL NARRATIVES; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Breznitz, Zvia
AU - Friedman, Sarah L.
T1 - TODDLERS' CONCENTRATION: DOES MATERNAL DEPRESSION MAKE A DIFFERENCE?
JO - Journal of Child Psychology & Psychiatry & Allied Disciplines
JF - Journal of Child Psychology & Psychiatry & Allied Disciplines
Y1 - 1988/05//
VL - 29
IS - 3
M3 - Article
SP - 267
EP - 279
SN - 00219630
AB - Twenty-five mother-toddler dyads with depressed mothers were compared with 25 dyads with well mothers on measures of attention during 20 mm of spontaneous play in a home-like setting. Children of depressed women focused attention on more objects for shorter durations. Group differences could be accounted for by mothers' involvement in their children's play. Depressed women initiated and terminated more instances of attention to objects than well mothers. Correlations between maternal behaviors and children's attention were statistically significant. Results support the hypothesis that poorer attention of children of depressed women is at least in part mediated by inculcation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Child Psychology & Psychiatry & Allied Disciplines is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOTHER & child
KW - DEPRESSION in women
KW - MATERNAL deprivation in infants
KW - AMUSEMENTS
KW - MATERNAL love
KW - TODDLERS -- Psychology
KW - Attention
KW - concentration
KW - maternal depression
N1 - Accession Number: 11987715; Breznitz, Zvia 1 Friedman, Sarah L. 1; Affiliation: 1: National Institute of Mental Health, University of Haifa, Israel.; Source Info: May1988, Vol. 29 Issue 3, p267; Subject Term: MOTHER & child; Subject Term: DEPRESSION in women; Subject Term: MATERNAL deprivation in infants; Subject Term: AMUSEMENTS; Subject Term: MATERNAL love; Subject Term: TODDLERS -- Psychology; Author-Supplied Keyword: Attention; Author-Supplied Keyword: concentration; Author-Supplied Keyword: maternal depression; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/1469-7610.ep11987715
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodley, David T.
AU - Stanley, John R.
AU - Reese, Melinda J.
AU - O'keefe, Edward J.
T1 - Human Dermal Fibroblasts Synthesize Laminin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1988/05//
VL - 90
IS - 5
M3 - Article
SP - 679
EP - 683
SN - 0022202X
AB - Laminin, a glycoprotein of approximately 900,000 daltons, is a major component of the basement membrane that separates the epidermis from dermis in human skin. Previous studies have shown that keratinocytes and other epithelial cells synthesize laminin and utilize it for attachment to other extracellular matrices such as heparan sulfate proteoglycan and basement membrane collagen. The relationships between phenotypically normal mesenchymal cells and laminin have been much less emphasized in the literature. In this study, we have used antibodies that specifically label the A and B chains of laminin (but not fibronectin or other unrelated proteins) by Western blot analysis to immunoprecipitate biosynthetically derived laminin from [35S] methionine labeled cultures of neonatal and adult human skin fibroblasts. To be sure that the precipitated bands were laminin and not fibronectin, which has a molecular size very close to that of the laminin B chains, experiments were performed in which fibronectin was removed from the radiolabeled proteins by first immunoprecipitating with antifibronectin antibody and then sequentially immunoprecipitating laminin from the fibronectin-depleted supernates with antilaminin antibody. These experiments definitively demonstrate that human dermal fibroblasts synthesize and secrete laminin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LAMINA epithelialis
KW - DERMIS
KW - FIBROBLASTS
KW - GLYCOPROTEINS
KW - BASAL lamina
KW - EPIDERMIS
N1 - Accession Number: 12560880; Woodley, David T. 1 Stanley, John R. 2 Reese, Melinda J. 1 O'keefe, Edward J. 1; Affiliation: 1: Department of Dermatology, UNC School of Medicine, Chapel Hill, North Carolina. 2: Department of Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: May88, Vol. 90 Issue 5, p679; Subject Term: LAMINA epithelialis; Subject Term: DERMIS; Subject Term: FIBROBLASTS; Subject Term: GLYCOPROTEINS; Subject Term: BASAL lamina; Subject Term: EPIDERMIS; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12560880
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ruchkin, Daniel S.
AU - Johnson Jr., Ray
AU - Mahaffey, David
AU - Sutton, Samuel
T1 - Toward a Functional Categorization of Slow Waves.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1988/05//
VL - 25
IS - 3
M3 - Article
SP - 339
EP - 353
SN - 00485772
AB - This study is concerned with slowly varying, long-duration brain event-related potential (ERP) components, referred to as Slow Wave activity. Slow Wave activity can be observed in the epoch following P3b, suggesting that it reflects further processing invoked by increased task demands, beyond the processing that underlies P3b. The present experiment was designed to distinguish Slow Wave activity related to specific types of task demands which arise during difficult perceptual (pattern recognition) and conceptual (arithmetic) mental operations. Three late ERP components that respond differentially in amplitude to manipulation of perceptual and conceptual difficulty were identified: 1) A P3b, with a topography focused about P[sub z], evidently related to the subjective categorization of easy and difficult conceptual operations, that increased when the subjective low-probability operation was performed; 2) A longer latency, centro-parietal positive Slow Wave that increased directly with perceptual difficulty but was not affected by conceptual difficulty; 3) A very long latency negative Slow Wave, broadly distributed over centro- posterior scalp, that increased directly with conceptual difficulty while its onset was delayed when perceptual difficulty increased. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVOKED potentials (Electrophysiology)
KW - BRAIN
KW - SCALP
KW - Event-related potentials
KW - Information processing.
KW - Mental arithmetic
KW - P3b
KW - Slow Wave
N1 - Accession Number: 11027371; Ruchkin, Daniel S. 1 Johnson Jr., Ray 2 Mahaffey, David 3 Sutton, Samuel 4; Affiliation: 1: Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland. 2: Clinical Neuropsychology Section, National institute of Neurological, Communicative Disorders & Stroke, Medical Neurology Branch, National institutes of Health, Bethesda, Maryland. 3: ARD Corporation, Columbia, Maryland. 4: Department of Psychophysiology, New York State Psychiatric Institute, New York, New York.; Source Info: May1988, Vol. 25 Issue 3, p339; Subject Term: EVOKED potentials (Electrophysiology); Subject Term: BRAIN; Subject Term: SCALP; Author-Supplied Keyword: Event-related potentials; Author-Supplied Keyword: Information processing.; Author-Supplied Keyword: Mental arithmetic; Author-Supplied Keyword: P3b; Author-Supplied Keyword: Slow Wave; Number of Pages: 15p; Document Type: Article
L3 - 10.1111/1469-8986.ep11027371
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shj-Xian Cao
AU - Schecuter, Alan N.
T1 - Nuclease hypersensitivity in the β-globin gene region of K562 cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/05/02/
VL - 173
IS - 3
M3 - Article
SP - 517
EP - 522
PB - Wiley-Blackwell
SN - 00142956
AB - We have investigated chromatin structure in the β-globin gene region of the K562 human erythroleukemic cell tine by using S1 and DNase I nuclease sensitivity assays. Despite the lack of β-globin gene expression in these cells, we find nuclease-hypersensitive sites to these enzymes in its 5' and 3' flanking regions in K562 chromatin, This result is in contrast to previous reports in which no hypersensitive sites were found in the immediate vicinity of this gene. In the 3' region, one major hypersensitive site at 0.9 kpb 3' and three minor hypersensitive sites at 0.7 kbp, 0.5 kbp 3' and 0.2 kbp 5' of the polyadenylation site were observed; these sites are very similar to those found in fetal liver and adult bone marrow cells in which the β-globin gene is expressed. We find hypersensitive sites to both enzymes in the 5' region of the β-globin gene: a major site 0.8 kbp 5' to the cap site, and two minor sites 1.2 and 1.5 kbp 5' to the cap site. The -0.8 kbp site is also present in plasmids containing the β-globin gene. Our results suggest that the lack of β-globin gene expression may be related to the lack of hypersensitivity sites in the immediate (150 bp) 5' flanking region of the β-globin gene, as occurs in other active globin genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - PROTEINS
KW - HEMOGLOBIN
KW - CELLS
KW - CHROMOSOMES
KW - GENETIC regulation
KW - GENE expression
KW - BONE marrow cells
N1 - Accession Number: 13774332; Shj-Xian Cao 1 Schecuter, Alan N. 1; Affiliation: 1: Laboratory of Chemical Biology, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland; Source Info: 5/2/88, Vol. 173 Issue 3, p517; Subject Term: GENES; Subject Term: PROTEINS; Subject Term: HEMOGLOBIN; Subject Term: CELLS; Subject Term: CHROMOSOMES; Subject Term: GENETIC regulation; Subject Term: GENE expression; Subject Term: BONE marrow cells; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaye, Walter H.
AU - Gwirtsman, Harry E.
AU - Obarzanek, Eva
AU - George, David T.
T1 - Relative importance of calorie intake needed to gain weight and level of physical activity in anorexia nervosa.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/06//
VL - 47
IS - 6
M3 - Article
SP - 989
EP - 994
SN - 00029165
AB - We assessed whether level of physical activity of anorexia nervosa patients could influence caloric consumption needed to gain weight during hospitalization. Seventy-three percent of patients with anorexia nervosa had higher levels of motor activity than did healthy female volunteers. Anorectics required 8301 ± 2272 kcal (mean ± SD) to gain 1 kg body wt. Activity levels and caloric consumption needed to gain I kg were significantly correlated; the most active patients needed to consume more calories to gain weight. A median split of anorectic patients by level of activity showed that the group with lower activity levels gained 1 kg every 5.1 ± 1.2 d, whereas the group with higher activity levels gained 1 kg every 7.2 ± 1.9 d. These data suggest that the rate of weight gain can be accelerated, and the cost of hospitalization decreased, by restricting exercise in anorectics during refeeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Anorexia nervosa
KW - Calorie
KW - Weight gain
KW - Hospital care
KW - Nutrition research
KW - Anorexia nervosa
KW - caloric utilization
KW - motor activity
KW - weight gain
N1 - Accession Number: 91710585; Kaye, Walter H. 1; Gwirtsman, Harry E. 2; Obarzanek, Eva 3; George, David T. 4; Affiliations: 1: Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA; 2: Neuropsychiatric Institute, Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, CA; 3: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD; 4: National Institute of Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD; Issue Info: Jun1988, Vol. 47 Issue 6, p989; Thesaurus Term: RESEARCH; Subject Term: Anorexia nervosa; Subject Term: Calorie; Subject Term: Weight gain; Subject Term: Hospital care; Subject Term: Nutrition research; Author-Supplied Keyword: Anorexia nervosa; Author-Supplied Keyword: caloric utilization; Author-Supplied Keyword: motor activity; Author-Supplied Keyword: weight gain; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Klebanoff, Mark A.
T1 - Short Interpregnancy Interval and the Risk of Low Birthweight.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/06//
VL - 78
IS - 6
M3 - Article
SP - 667
EP - 670
PB - American Public Health Association
SN - 00900036
AB - The effect of interpregnancy interval on the birthweight of the subsequent child was investigated in a cohort of 5,938 women who registered for two consecutive pregnancies in the Collaborative Perinatal Project, Mean birthweight increased from 3,101 grams for intervals of <3 months to 3,193 grams for intervals of 15–17,9 months and remained stable thereafter (p for trend = 0,006), However, women with shorter intervals were younger, lighter weight, and less educated at the beginning of the first pregnancy than were women with longer intervals; the birthweight of their previous child was lower, and they were of marginally lower socioeconomic status. Adjustment for confounders reduced the maximum difference in mean birthweight by interval length from 92 to 39 grams, and blunted the trend for lower birthweights with shorter intervals (p = 0,45), Similarly, adjustment reduced the increased risk of low birthweight among women with the shortest intervals from 52 per cent to 12 per cent. We conclude that a short interpregnancy interval is primarily a marker for a woman who is otherwise at high risk, and that modification of this interval alone may be unlikely to have a major impact on low birthweight. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANCY
KW - LOW birth weight
KW - DELIVERY (Obstetrics)
KW - CHILDBIRTH
KW - MATERNAL health services
KW - FETAL growth retardation
KW - SOCIODEMOGRAPHIC factors
KW - NEONATAL intensive care
KW - CONCEPTION
N1 - Accession Number: 4693174; Klebanoff, Mark A. 1; Affiliation: 1: Epidemiology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Landow building, Rm 8A04, Bethesda, MD 20892; Source Info: Jun88, Vol. 78 Issue 6, p667; Subject Term: PREGNANCY; Subject Term: LOW birth weight; Subject Term: DELIVERY (Obstetrics); Subject Term: CHILDBIRTH; Subject Term: MATERNAL health services; Subject Term: FETAL growth retardation; Subject Term: SOCIODEMOGRAPHIC factors; Subject Term: NEONATAL intensive care; Subject Term: CONCEPTION; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dannenberg, Andrew L.
AU - Garrison, Robert J.
AU - Kannel, William B.
T1 - Incidence of Hypertension in the Framingham Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/06//
VL - 78
IS - 6
M3 - Article
SP - 676
EP - 679
PB - American Public Health Association
SN - 00900036
AB - Incidence and trends in incidence of definite hypertension ere analyzed based on 30 years follow-up of 5.209 subjects in the Framingham Heart Study cohort. Based on pooling of 15 two-year periods, hypertension incidence per biennium increased with age in men from 3.3 percent at ages 30–39 to 6.2 percent at ages 70–79, and in women from 1.5 per cent at ages 30–39 to 8.6 per cent at ages 70–79. No consistent trend in incidence rates was evident for either sex from the 1950s through the 1970s. The proportion of hypertensive subjects receiving antihypertensive medication has increased since 1954–58 and exceeded 80 per cent for both men and women ages 60–89 years in 1979–81. Incidence data presented in this report may serve as a baseline for assessing the impact of future public health efforts in the primary prevention of hypertension. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTENSION
KW - CARDIOVASCULAR diseases
KW - BLOOD pressure
KW - BLOOD circulation disorders
KW - MEDICAL care
KW - PUBLIC health
KW - HEALTH education
KW - HUMAN services
KW - FRAMINGHAM Heart Study (Organization)
N1 - Accession Number: 4693241; Dannenberg, Andrew L. 1 Garrison, Robert J. 1 Kannel, William B. 2; Affiliation: 1: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda 2: Section of Preventive Medicine and Epidemiology, Boston University, School of Medicine; Source Info: Jun88, Vol. 78 Issue 6, p676; Subject Term: HYPERTENSION; Subject Term: CARDIOVASCULAR diseases; Subject Term: BLOOD pressure; Subject Term: BLOOD circulation disorders; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: HEALTH education; Subject Term: HUMAN services; Company/Entity: FRAMINGHAM Heart Study (Organization); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donahue, Richard P.
AU - Abbott, Robert D.
AU - Reed, Dwayne M.
AU - Yano, Katsuhiko
T1 - Physical Activity and Coronary Heart Disease in Middle-Aged and Elderly Men: The Honolulu Heart Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/06//
VL - 78
IS - 6
M3 - Article
SP - 683
EP - 685
PB - American Public Health Association
SN - 00900036
AB - The relationship of physical activity to the development of definite coronary heart disease was examined separately in middle-aged (45–64 years) and elderly men (65–69 years) participating in the Honolulu Heart Program. After 12 years of follow-up, results indicate that increased levels of physical activity reported at study entry were inversely related to the risk of definite coronary heart disease in both age groups. In particular, among those aged 45 to 64 years, the rate of definite coronary heart disease in men who led active life styles was 30 per cent lower than the rate experienced by those who were less active (relative risk, 0.69; 95% confidence interval, 0.53, 0.88). In those older than 64 years, the rate of definite coronary heart disease in active men was less than half the rate experienced by those who led more sedentary life styles (relative risk, 0.43; 95% Cl, 0.19, 0.99). These results continued to hold up when controlling for several cardiovascular risk factors and potentially confounding variables, supporting earlier observations that physical activity is beneficial in middle-age, and further suggesting that benefits may extend to the elderly male population as well. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY heart disease
KW - CARDIOVASCULAR diseases
KW - PHYSICAL fitness
KW - MIDDLE-aged persons
KW - OLDER men
KW - DISEASES -- Risk factors
KW - HEALTH promotion
KW - HONOLULU (Hawaii)
KW - HAWAII
N1 - Accession Number: 4693419; Donahue, Richard P. 1 Abbott, Robert D. 2 Reed, Dwayne M. 3 Yano, Katsuhiko 4; Affiliation: 1: Department of Medicine, Division of General Medicine and Primary Care, University of Massachusetts Medical Center, 55 Lake Avenue, North Worcester, MA 01655 2: Statistical Resource Section, National Heart, Lung, and Blood Institute, Bethesda, MD 3: Honolulu Epidemiology Research Section, NHLBL Honolulu, HI 96817 4: Honolulu Heart Program, Kuakini Medical Center, Honolulu; Source Info: Jun88, Vol. 78 Issue 6, p683; Subject Term: CORONARY heart disease; Subject Term: CARDIOVASCULAR diseases; Subject Term: PHYSICAL fitness; Subject Term: MIDDLE-aged persons; Subject Term: OLDER men; Subject Term: DISEASES -- Risk factors; Subject Term: HEALTH promotion; Subject Term: HONOLULU (Hawaii); Subject Term: HAWAII; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Furue, Masutaka
AU - Gaspari, Anthony A.
AU - Katz, Stephen I.
T1 - The Effect of Cyclosporin A on Epidermal Cells. II. Cyclosporin A Inhibits Proliferation of Normal and Transformed Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1988/06//
VL - 90
IS - 6
M3 - Article
SP - 796
EP - 800
SN - 0022202X
AB - Cylcosporin A (CSA) is a potent immunosuppressive drug that inhibits the proliferation of activated T cells by blocking the production of interleukin 2. Recent studies have demonstrated that CSA also inhibits the proliferation of neoplastic cells of hematopoietic and nonhematopoietic origin. CSA has also been reported to be effective in the treatment of psoriasis, which is characterized by epidermal hyperproliferation. As so many of the therapeutically effective agents in psoriasis are antiproliferative, we sought to determine whether CSA affects the proliferation of keratinocytes. We studied the effect of CSA on the proliferation of normal and transformed keratinocytes and demonstrated that CSA inhibits DNA synthesis and proliferation of keratinocytes. CSA also inhibits DNA synthesis of other neoplastic cells of hematopoietic and nonhematopoietic origin. These findings indicate the CSA inhibits the proliferation of various cell types. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOSPORINE
KW - LANGERHANS cells
KW - KERATINOCYTES
KW - T cells
KW - INTERLEUKIN-2
KW - IMMUNOSUPPRESSIVE agents
N1 - Accession Number: 12462009; Furue, Masutaka 1 Gaspari, Anthony A. 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jun88, Vol. 90 Issue 6, p796; Subject Term: CYCLOSPORINE; Subject Term: LANGERHANS cells; Subject Term: KERATINOCYTES; Subject Term: T cells; Subject Term: INTERLEUKIN-2; Subject Term: IMMUNOSUPPRESSIVE agents; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12462009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12462009&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr., Paul T.
T1 - Recalled Parent-Child Relations and Adult Personality.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1988/06//
VL - 56
IS - 2
M3 - Article
SP - 417
EP - 434
PB - Wiley-Blackwell
SN - 00223506
AB - Adult children's ratings of their parents' behaviors on the Parent-Child Relation Questionnaire 11 were correlated with self-reports and peer ratings of personality on the NEO Personality Inventory in a sample of 619 men and women aged 21 to 96. Individuals who reported that their parents were loving scored lower in neuroticism and higher in extraversion, openness to experience, agreeableness, and conscientiousness Individuals, especially men, who described their parents as casual rather than demanding were lower in extraversion and conscientiousness, but higher in openness. Parental attention (i.e. spoiling) was associated with extraversion and low agreeableness. Several of these correlations were replicated when peer ratings of personality were examined. However, all the associations were modest, and several alternative explanations suggest that the correlations may exaggerate the influence of these child rearing practices on adult personality Parental behaviors and attitudes seem to have less effect on broad dimensions of adult personality than traditionally supposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARENT & child
KW - ADOLESCENT psychology
KW - EXTRAVERSION
KW - PERSONALITY
KW - HUMAN behavior
KW - INTERPERSONAL relations
N1 - Accession Number: 8970948; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Jun88, Vol. 56 Issue 2, p417; Subject Term: PARENT & child; Subject Term: ADOLESCENT psychology; Subject Term: EXTRAVERSION; Subject Term: PERSONALITY; Subject Term: HUMAN behavior; Subject Term: INTERPERSONAL relations; Number of Pages: 18p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970948
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8970948&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr, Paul T.
T1 - Do Parental Influences Matter? A Reply to Halverson.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1988/06//
VL - 56
IS - 2
M3 - Article
SP - 445
EP - 449
PB - Wiley-Blackwell
SN - 00223506
AB - Halverson (1988) raises many objections to the retrospective method, but only some of them are applicable to our study (McCrae & Costa, 1988), further,Halverson fails to distinguish between random error and bias in retrospective data. We argue that retrospective accounts can provide one useful source of evidence when the probable effects of biases are taken into account. The small associations between recalled parent child relations and adult personality that we reported were probably exaggerated rather than masked by retrospective bias, we took this into account in reaching our conclusions. Rather than dismiss the method, psychologists should question the entrenched belief that child-rearing is a major determinant of adult personality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD psychology
KW - PARENT & child
KW - LONGITUDINAL method
KW - SOCIAL science research
KW - PSYCHOLOGISTS
KW - CHILD rearing
N1 - Accession Number: 8970995; McCrae, Robert R. 1 Costa Jr, Paul T. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH; Source Info: Jun88, Vol. 56 Issue 2, p445; Subject Term: CHILD psychology; Subject Term: PARENT & child; Subject Term: LONGITUDINAL method; Subject Term: SOCIAL science research; Subject Term: PSYCHOLOGISTS; Subject Term: CHILD rearing; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1467-6494.ep8970995
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brookmever, Ron
AU - Gail, Mitchell H.
T1 - A Method for Obtaining Short-Term Projections and Lower Bounds on the Size of the AIDS Epidemic.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1988/06//
VL - 83
IS - 402
M3 - Article
SP - 301
SN - 01621459
AB - A methodology is proposed for obtaining short-term projections of the acquired immunodeficiency syndrome (AIDS) epidemic by projecting the number of cases from those already infected with the AIDS virus. This is a lower bound on the size of the AIDS epidemic, because even if future infections could be prevented, one could still anticipate this number of cases. The methodology is novel in that no assumptions are required about either the number of infected individuals in the population or the probability of an infected individual eventually developing AIDS. The methodology presupposes knowledge of the incubation distribution, however, among those destined to develop AIDS. Although the method does not account for new infections, it may produce accurate short-term projections because of the relatively long incubation period from infection to clinically diagnosed AIDS. The estimation procedure "back-calculates" from AIDS incidence data to numbers previously infected. The number of cases diagnosed in each calendar period has a multinomial distribution with cell probabilities that can be expressed as a convolution of the density of infection times and the incubation distribution. The problem is shown to reduce to estimating the size of a multinomial population. A simple EM algorithm is developed for obtaining maximum likelihood estimates when the density of infection times is parameterized as a step function. The methodology is applied to AIDS incidence data in the United States, to obtain short-term projections and an estimate of the minimum size of the epidemic by assuming no new infections in 1987 and after. The sensitivity of the projections to the assumed incubation distribution is investigated. It was found that short-term projections are not nearly as... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - FORECASTING
KW - AIDS (Disease)
KW - METHODOLOGY
KW - COMMUNICABLE diseases
KW - IMMUNOLOGICAL deficiency syndromes
KW - EPIDEMIOLOGY
KW - INFECTION
KW - Epidemiology
KW - Infectious diseases
KW - Multinomial distribution.
N1 - Accession Number: 4608312; Brookmever, Ron 1; Gail, Mitchell H. 2; Affiliations: 1: Associate Professor, Department of Biostatistics, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.; 2: Head, Epidemiologic Methods Section, Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892.; Issue Info: Jun88, Vol. 83 Issue 402, p301; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: FORECASTING; Subject Term: AIDS (Disease); Subject Term: METHODOLOGY; Subject Term: COMMUNICABLE diseases; Subject Term: IMMUNOLOGICAL deficiency syndromes; Subject Term: EPIDEMIOLOGY; Subject Term: INFECTION; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Infectious diseases; Author-Supplied Keyword: Multinomial distribution.; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2006-05462-045
AN - 2006-05462-045
AU - Zahn, Theodore P.
T1 - Psychoneuroendocrinology in a nutshell.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/06//
VL - 33
IS - 6
SP - 534
EP - 535
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05462-045. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn, Theodore P.; Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Neuroendocrinology; Physiology; Stress. Minor Descriptor: History. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Reviewed Item: Asterita, Mary F. The Physiology of Stress: With Special Reference to the Neuroendocrine System=New York: Human Sciences Press, 1985. 281 pp. $16.95 paperback; 1985. Page Count: 2. Issue Publication Date: Jun, 1988.
AB - Reviews the book, The Physiology of Stress: With Special Reference to the Neuroendocrine System by Mary F. Asterita (1985). The book begins and ends with short historical accounts of the influential contributions of Cannon and Selye and, to a lesser extent, the earlier contributions of Claude Bernard and the more recent ones of John Mason. Various concepts of stress were held by these authors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroendocrine system
KW - historical accounts
KW - physiology
KW - stress
KW - 1988
KW - Neuroendocrinology
KW - Physiology
KW - Stress
KW - History
KW - 1988
U2 - Asterita, Mary F. (1985); The Physiology of Stress: With Special Reference to the Neuroendocrine System; New York: Human Sciences Press, 1985. 281 pp. $16.95 paperback
DO - 10.1037/025805
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - NELSON, PHILLIP G.
T1 - Early Behavioral Plasticity.
JO - Science
JF - Science
Y1 - 1988/06/03/
VL - 240
IS - 4857
M3 - Article
SP - 1351
EP - 1352
SN - 00368075
N1 - Accession Number: 87460475; NELSON, PHILLIP G. 1; Affiliation: 1: Laboratory of Developmntal Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20892; Source Info: 6/3/1988, Vol. 240 Issue 4857, p1351; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ota, Akira
AU - Wilson, Gaye Lynn
AU - Leroith, Derek
T1 - Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two β subunits are derived from differences in glycosylation.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/06/15/
VL - 174
IS - 3
M3 - Article
SP - 521
EP - 530
PB - Wiley-Blackwell
SN - 00142956
AB - We have characterized receptors for the insulin-like growth factor (IGF-I) on the mouse neuroblastoma cell line N18 as well as NG108, the hybrid cell line of N18 and rat glioma (C6). In this cell-free system, IGF-I and insulin stimulated the phosphorylation of 95-kDa and 105-kDa proteins. Using appropriate antibodies we were able to demonstrate that the IGF-I receptor β subunit has two subtypes of 95 kDa and 105 kDa. On the other hand, insulin receptor β subunit is a separate single 95-kDa protein. Enzymatic digestion of IGF-I receptor β subunit subtypes by glycopeptidase F resulted in similar molecular masses (84 kDa and 86 kDa) on SDS-PAGE, which suggests that the difference in molecular masses between two subtypes is attributable to the differences in N-linked complex-type carbohydrate chains on the extracellular domain of β subunits. This conclusion is further supported by peptides of similar molecular mass following staphylococcal V8 protease digestion. Analysis of IGF-I receptor β subunit subtypes in these cells may provide insights into the mechanism of action of IGF-I on neural tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOMATOMEDIN
KW - NEUROBLASTOMA
KW - GLIOMAS
KW - INSULIN
KW - PHOSPHORYLATION
KW - NERVOUS system
N1 - Accession Number: 13795385; Ota, Akira 1 Wilson, Gaye Lynn 1 Leroith, Derek 1; Affiliation: 1: Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda; Source Info: 6/15/88, Vol. 174 Issue 3, p521; Subject Term: SOMATOMEDIN; Subject Term: NEUROBLASTOMA; Subject Term: GLIOMAS; Subject Term: INSULIN; Subject Term: PHOSPHORYLATION; Subject Term: NERVOUS system; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 119526819
T1 - Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin.
AU - Kraemer, K H
AU - DiGiovanna, J J
AU - Moshell, A N
AU - Tarone, R E
AU - Peck, G L
Y1 - 1988/06/23/
N1 - Accession Number: 119526819. Language: English. Entry Date: 19880901. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Checklist Individual Strength (CIS). Grant Information: Z01 BC004517-31//Intramural NIH HHS/United States. NLM UID: 0255562.
KW - Xeroderma Pigmentosum -- Complications
KW - Skin Neoplasms -- Prevention and Control
KW - Tretinoin -- Administration and Dosage
KW - Clinical Trials
KW - Administration, Oral
KW - Female
KW - Tretinoin -- Therapeutic Use
KW - Carcinoma, Squamous Cell -- Prevention and Control
KW - Adolescence
KW - Tretinoin -- Adverse Effects
KW - Isotretinoin
KW - Male
KW - Prospective Studies
KW - Adult
KW - Child
KW - Human
KW - Carcinoma, Basal Cell -- Prevention and Control
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Checklists
SP - 1633
EP - 1637
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 318
IS - 25
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - To confirm reports that skin cancer can be prevented with retinoids, we conducted a three-year controlled prospective study of oral isotretinoin (also called 13-cis retinoic acid) in five patients with xeroderma pigmentosum who had a history of multiple cutaneous basal-cell or squamous-cell carcinomas. Patients were treated with isotretinoin at a dosage of 2 mg per kilogram of body weight per day for two years and then followed for an additional year, without the drug. Before, during, and after treatment, biopsies of all suspicious lesions were performed, and skin cancers were surgically removed. The patients had a total of 121 tumors (mean, 24; range, 8 to 43) in the two-year interval before treatment. During two years of treatment with isotretinoin, there were 25 tumors (mean, 5; range, 3 to 9), with an average reduction in skin cancers of 63 percent (P = 0.019). After the drug was discontinued, the tumor frequency increased a mean of 8.5-fold (range, 2- to 19-fold) over the frequency during treatment (P = 0.007). Although all patients experienced mucocutaneous toxic effects, and triglyceride, liver-function, or skeletal abnormalities developed in some, high-dose oral isotretinoin was effective in the chemoprophylaxis of skin cancers in patients with xeroderma pigmentosum.
SN - 0028-4793
AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Md 20892
U2 - PMID: 3287161.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bornstein, Marc H.
T1 - The Perceptual World of the Infant.
JO - American Scientist
JF - American Scientist
Y1 - 1988/07//Jul/Aug88
VL - 76
IS - 4
M3 - Book Review
SP - 395
SN - 00030996
AB - Reviews the books "Perceptual Development in Early Infancy: Problems and Issues," edited by Beryl E. McKenzie and Rose H. Day and "Perceptual Development in Infancy: The Minnesota Symposia on Child Psychology," edited by Albert Yonas.
KW - McKenzie, Beryl
KW - Day, Rose
KW - Yonas, Albert
KW - Perceptual Development in Early Infancy: Problems & Issues (Book)
N1 - Accession Number: 11802340; Bornstein, Marc H. 1; Affiliations: 1: National Institute of Child Health and Human Development, Bethesda, MD; Issue Info: Jul/Aug88, Vol. 76 Issue 4, p395; Reviews & Products: Perceptual Development in Early Infancy: Problems & Issues (Book); People: McKenzie, Beryl; People: Day, Rose; People: Yonas, Albert; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nagel, James E.
T1 - OUT-OF-DATE VIRUSES.
JO - BioScience
JF - BioScience
Y1 - 1988/07//Jul/Aug88
VL - 38
IS - 7
M3 - Book Review
SP - 512
EP - 512
SN - 00063568
AB - Reviews the book "Viruses, Immunity, and Immunodeficiency," edited by Andor Szentivany and Herman Friedman.
KW - Viruses
KW - Nonfiction
KW - Viruses, Immunity & Immunodeficiency (Book)
N1 - Accession Number: 10113437; Nagel, James E. 1; Affiliations: 1: National Institutes of Health, National Institute on Aging Gerontology Research Center, Bethesda, MD 21224; Issue Info: Jul/Aug88, Vol. 38 Issue 7, p512; Thesaurus Term: Viruses; Subject Term: Nonfiction; Reviews & Products: Viruses, Immunity & Immunodeficiency (Book); Number of Pages: 1/2p; Document Type: Book Review; Full Text Word Count: 389
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Marcon, Luisa
AU - Fritz, Mary E.
AU - Kurman, Carole C.
AU - Jensen, J. C.
AU - Nelson, D. L.
T1 - Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL).
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1988/07//
VL - 73
IS - 1
M3 - Article
SP - 29
EP - 33
PB - Wiley-Blackwell
SN - 00099104
AB - The T lymphocyte-derived lymphokine interleukin 2 and the cell-associated receptor for this molecule play major roles in the activation and regulation of the human immune response. An enzyme-linked immunosorbent assay has been developed to measure quantitatively a soluble form of one component of the human interleukin 2 receptor, namely the Tac peptide. In the present studies, soluble Tac peptide was measured in the urine of normal individuals (mean =92 U/ml), a level not significantly different (0.01 < P<0.05) from the corresponding serum concentrations (mean= 175). The urinary Tac peptide had a molecular weight of 40-45 kD by sodium dodecyl sulphatepolyacrylamide gel electrophoresis analysis and specifically bound interleukin 2. Elevated levels of urinary Tac peptide were found in four patients with adult T cell leukaemia who also had elevated serum levels of Tac peptide. Thus, urine may represent a valuable source of lymphokine-binding proteins that may serve as important markers of immunological activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - LYMPHOKINES
KW - URINE
KW - INTERLEUKIN-2
KW - LEUKEMIA
KW - CANCER
KW - 2
KW - interleukin
KW - peptide
KW - receptor
KW - Tac
N1 - Accession Number: 16173480; Marcon, Luisa 1 Fritz, Mary E. 1 Kurman, Carole C. 1 Jensen, J. C. 2 Nelson, D. L. 1; Affiliation: 1: Immunophysiology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. 2: Hoffman La Roche, Inc., Nutley, NJ, USA.; Source Info: Jul1988, Vol. 73 Issue 1, p29; Subject Term: T cells; Subject Term: LYMPHOKINES; Subject Term: URINE; Subject Term: INTERLEUKIN-2; Subject Term: LEUKEMIA; Subject Term: CANCER; Author-Supplied Keyword: 2; Author-Supplied Keyword: interleukin; Author-Supplied Keyword: peptide; Author-Supplied Keyword: receptor; Author-Supplied Keyword: Tac; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ZAHAREVITZ, Daniel W.
AU - NAPIER, Elizabeth A.
AU - ANDERSON, Lawrence W.
AU - STRONG, John M.
AU - CYSYK, Richard L.
T1 - Stimulation of uracil nucleotide synthesis in mouse liver, intestine and kidney by ammonium chloride infusion.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/07//7/1/88
VL - 175
IS - 1
M3 - Article
SP - 193
EP - 198
PB - Wiley-Blackwell
SN - 00142956
AB - De novo pyrimidine synthesis was studied in mouse liver, intestine, and kidney by intraperitoneal infusion of 15NH4Cl and analysis of 15N incorporation into uracil nucleotide pools. When the dose of a 1-h infusion of 15NH4Cl was increased from 50 μmol to 250 μmol the fraction of the total uracil nucleotide pool formed by de novo synthesis increased 4.0-fold in liver to 8.4% and 2.3-fold in intestine to 13.7%. The increase in intestine was independent of the increase in liver as evidenced by the lack of correlation between the increase observed in the intestine and liver of the same animal and the different distributions of label in the uracil ring nitrogens. A 2.4-fold increase in newly formed uracil nucleotides was observed in kidney when the infusion dose was raised from 150 μmol to 250 μmol. The increase in kidney was correlated with the increase in liver in the same animal and the distribution of label in the uracil ring nitrogens was similar to the distribution in liver. These results suggest that the increase in newly formed uracil nucleotides in intestine is due to increased de novo synthesis of pyrimidines in the intestine, while the increase in the kidney is due to increased salvage synthesis of uracil nucleotides from uridine synthesized in the liver and output to the circulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 120460854; ZAHAREVITZ, Daniel W. 1 NAPIER, Elizabeth A. 1 ANDERSON, Lawrence W. 1 STRONG, John M. 1 CYSYK, Richard L. 1; Affiliation: 1: Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD.; Source Info: 7/1/88, Vol. 175 Issue 1, p193; Number of Pages: 6p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saxena, R. K.
AU - Saxena, Q. B.
AU - Adler, W. H.
T1 - Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response.
JO - Immunology
JF - Immunology
Y1 - 1988/07//
VL - 64
IS - 3
M3 - Article
SP - 457
EP - 461
PB - Wiley-Blackwell
SN - 00192805
AB - Concanavalin A (Con A)-induced cytotoxic activity, interferon (IFN) and interleukin-2 (IL-2) levels in cultures of spleen cells from young (2-3 months) and old (22-24 months) C578L/6 female mice were studied. Con A-activated spleen cells from old mice attained significantly higher cytotoxic activity compared with activated spleen cells from young mice. Activated spleen cells from old and young mice showed differences in their ability to lyse different types of target cells. Both could lyse P 815 cells, neither could lyse K562 cells, and only activated cells from old mice could lyse EL-4 cells. Cytotoxic spleen cells from the old mice were more sensitive to anti-asialo-GM-l and anti-Lyt-2.2 plus complement (C) treatment. While levels of IL-2 produced by spleen cells from young mice were higher, the addition of exogenous IL-2 had no effect on cytotoxic activity of the spleen cells from old mice. Exogenous IL-2, however, could lower cytotoxic activity of Con A-activated spleen cells from young mice. Activated spleen cells from old mice generated higher levels of IFN-γ while the addition of an anti-IFN-γ antibody boosted the level of cytotoxicity by Con A-activated spleen cells from young mice. These results suggest that IFN-γ may act as a feedback inhibitory signal regulating the levels of cytotoxicity induced in spleen cells from young mice in response to Con A. The cytotoxic activity generated in Con A-activated spleen cells from old mice reflects a defect in this feed-back regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTINEOPLASTIC agents
KW - ANTIVIRAL agents
KW - LYMPHOKINES
KW - INTERLEUKIN-2
KW - T cells
KW - SPLEEN
N1 - Accession Number: 14008620; Saxena, R. K. 1 Saxena, Q. B. 1 Adler, W. H. 2; Affiliation: 1: School of Life Sciences, Jawaharlal Nehru University, New Delhi. 2: Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland U.S.A.; Source Info: Jul88, Vol. 64 Issue 3, p457; Subject Term: ANTINEOPLASTIC agents; Subject Term: ANTIVIRAL agents; Subject Term: LYMPHOKINES; Subject Term: INTERLEUKIN-2; Subject Term: T cells; Subject Term: SPLEEN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104760039
T1 - Chronic fungal sinusitis in apparently normal hosts.
AU - Washburn, R G
AU - Kennedy, D W
AU - Begley, M G
AU - Henderson, D K
AU - Bennett, J E
Y1 - 1988/07//1988 Jul
N1 - Accession Number: 104760039. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R.
KW - Mycoses -- Diagnosis
KW - Mycoses -- Pathology
KW - Mycoses -- Radiography
KW - Sinusitis -- Diagnosis
KW - Sinusitis -- Pathology
KW - Sinusitis -- Radiography
KW - Adult
KW - Chronic Disease
KW - Diagnosis, Differential
KW - Female
KW - Male
KW - Paranasal Sinuses -- Anatomy and Histology
KW - Paranasal Sinuses -- Pathology
KW - Paranasal Sinuses -- Radiography
KW - Tomography, X-Ray Computed
SP - 231
EP - 247
JO - Medicine
JF - Medicine
JA - MEDICINE
VL - 67
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Several fungal species are capable of causing either noninvasive fungal sinusitis or invasive disease characterized by erosion into mucosa, submucosa, bone, and deeper contiguous structures. The diagnosis of invasive infection becomes firmly established only after histologic demonstration of hyphae within these areas. Computerized tomography and magnetic resonance imaging can assist in distinguishing between invasive and noninvasive disease by outlining bone and adjacent structures. The 2 forms of chronic fungal sinusitis mandate different therapeutic approaches. While patients with noninvasive infection require only surgical removal of hyphal masses and the reestablishment of sinus drainage for a successful outcome, invasive infection necessitates not only thorough surgical debridement of abnormal tissues but may also require prolonged antifungal chemotherapy. All patients require long-term follow-up. Even the combined approach has sometimes proven disappointing during long-term follow-up of disease, rendering investigational therapy appropriate in some patients.
SN - 0025-7974
AD - Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
U2 - PMID: 3393078.
DO - 10.1097/00005792-198807000-00004
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Carter, J W
AU - Perry, D J
AU - Tingley, D E
T1 - How to automate a service desk using dBASE III PLUS
JO - Online
JF - Online
Y1 - 1988/07//
VL - 12
IS - 4
M3 - Article
SP - 120
EP - 124
SN - 01465422
AB - This article describes a database created on dBASE III PLUS containing frequently requested information from the National Cancer Institute's International Cancer Research Data Bank (ICRDB) service desk. Design and use of the database are discussed. An evaluation is also provided.
KW - DATABASES
KW - Automation
KW - Cancer
KW - Computer programs
N1 - Accession Number: ISTA2302614; Carter, J W 1; Perry, D J; Tingley, D E; Affiliations: 1 : National Cancer Institute Bethesda, MD; Source Info: Jul 1988, Vol. 12 Issue 4, p120; Note: Update Code: 2300; Subject Term: DATABASES; Author-Supplied Keyword: Automation; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Computer programs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
T1 - Living with AIDS and HIV (Book).
AU - Baron, David A.
JO - Stress Medicine
JF - Stress Medicine
Y1 - 1988/07//Jul/Sep88
VL - 4
IS - 3
SP - 179
EP - 179
SN - 07488386
N1 - Accession Number: 12056201; Author: Baron, David A.: 1 ; Author Affiliation: 1 National Institute of Mental Health, Bethesda, USA; No. of Pages: 1/3; Language: English; Publication Type: Book Review; Update Code: 20040127
N2 - Reviews the book "Living With AIDS and HIV," by David Miller.
KW - *HIV infections
KW - *AIDS (Disease)
KW - NONFICTION -- Reviews
KW - NONFICTION
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 2006-05463-009
AN - 2006-05463-009
AU - Shah, Saleem A.
T1 - A Critique of Legal Psychology.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/07//
VL - 33
IS - 7
SP - 586
EP - 588
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05463-009. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Shah, Saleem A.; Antisocial and Violent Behavior Branch, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Adjudication; Forensic Psychology; Laws; Legal Processes. Minor Descriptor: Criminal Justice. Classification: Forensic Psychology & Legal Issues (4200). Population: Human (10). Reviewed Item: King, Michael. Psychology in and Out of Court: A Critical Examination of Legal Psychology=Oxford, England: Pergamon Press, 1986. 119 pp. $19.75; 1986. References Available: Y. Page Count: 3. Issue Publication Date: Jul, 1988.
AB - Reviews the book, Psychology in and Out of Court: A Critical Examination of Legal Psychology by Michael King (see record [rid]1987-97211-000[/rid]). There is a fairly long history of research and related interests in the law, legal systems, and processes by psychologists from a variety of specialties. In this concise book, King provides a fairly scathing critique of what he refers to as 'legal psychology,' from the perspective of 'an English lawyer qualified in psychology.' The author indicates that he plans to make a fairly disciplined use of terms such as the law and legal processes in addressing the topics of concern. Thus, when talking about the law, he is actually referring to the legal system, the criminal justice system (which is concerned with administration of the criminal law), and legal processes. Unfortunately, the value of this book is seriously compromised by several problemmatic features. The author seems to have many axes to grind. This quality is as persistent as it is also striking. There is a penchant for overstatements, extravagant rhetoric, sweeping generalizations, and unqualified and unsubstantiated assertions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - legal psychology
KW - criminal justice system
KW - criminal law
KW - legal processes
KW - courts
KW - 1988
KW - Adjudication
KW - Forensic Psychology
KW - Laws
KW - Legal Processes
KW - Criminal Justice
KW - 1988
U2 - King, Michael. (1986); Psychology in and Out of Court: A Critical Examination of Legal Psychology; Oxford, England: Pergamon Press, 1986. 119 pp. $19.75; 0-08-026798-X.
DO - 10.1037/030463
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05463-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - STAUDT, LOUIS M.
AU - CLERC, ROGER G.
AU - SINGH, HARINDER
AU - LEBOWITZ, JONATHAN H.
AU - SHARP, PHILLIP A.
AU - BALTIMORE, DAVID
T1 - Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif.
JO - Science
JF - Science
Y1 - 1988/07/29/
VL - 241
IS - 4865
M3 - Article
SP - 577
EP - 580
SN - 00368075
AB - An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes. A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in λgt11 phage to derive molecular cDNA clones representing a putative B lymphocyte-specific octamer binding protein. The plaques were screened with DNA containing four copies of the octamer sequence and positive phage recombinants were identified. The fusion protein produced on inducing a lysogen ofone phage bound to a monomeric octamer probe. The cDNA insert from this phage hybridized to messenger RNA found in B lymphocytes, but not in most other cells. Thus, this cDNA derives from a gene (oct-2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell-specific transcription factor exists and its amount is controlled through messenger RNA availability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460509; STAUDT, LOUIS M. 1,2,3 CLERC, ROGER G. 4 SINGH, HARINDER 4 LEBOWITZ, JONATHAN H. 4 SHARP, PHILLIP A. 4 BALTIMORE, DAVID 1,2; Affiliation: 1: Whitehead Institute for Biomedical Research, Cambridge, MA 02142 2: Department of Biology, Massachusetts Institute ofTechnologv, Cambridge, MA 02139 3: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4: Center for Cancer Research and Departmnent of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Source Info: 7/29/1988, Vol. 241 Issue 4865, p577; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dimitrov, Nikolay V.
AU - Meyer, Cheryl
AU - Ullrey, Duane E.
AU - Chenoweth, Wanda
AU - Michelakis, Andrew
AU - Malone, Winfred
AU - Boone, Charles
AU - Fink, Gregory
T1 - Bioavailability of β-carotene in humans.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/08//
VL - 48
IS - 2
M3 - Article
SP - 298
EP - 304
SN - 00029165
AB - Normal healthy volunteers were studied after they ingested various β- carotene doses. Daily administration of 15 or 45 mg β-carotene resulted in significant increase in plasma β-carotene levels. The extent of increase and the pattern of plasma β-carotene levels showed substantial interindividual variation. Absorption of β-carotene was affected by dietary fat concentration. Individuals placed on a high-fat diet showed significant increases in plasma β-carotene as compared with those placed on a low-fat diet. Pharmacological doses of β-carotene (45 and 90 mg) were used in intermittent schedules (5-6 d intervals) without altering the steady state of β-carotene plasma levels. Yellowing of the skin occasionally occurred during daily dosing with 45 mg β-carotene without evidence of toxicity. The observed individual variation in bioavailability of β-carotene raises questions regarding clinical use of this micronutrient. It appears that determination of target plasma β-carotene concentrations is essential for effective use of this compound in prevention or treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bioavailability
KW - HEALTH
KW - Toxicity testing
KW - Medical personnel
KW - Volunteers
KW - Blood plasma
KW - β-carotene
KW - bioavailability
KW - high-fat diet
KW - humans
KW - low-fat diet
KW - target concentration
N1 - Accession Number: 91711289; Dimitrov, Nikolay V. 1,2,3; Meyer, Cheryl 1,2,3; Ullrey, Duane E. 1,2,3; Chenoweth, Wanda 1,2,3; Michelakis, Andrew 1,2,3; Malone, Winfred 1,2,3; Boone, Charles 1,2,3; Fink, Gregory 1,2,3; Affiliations: 1: Department of Medicine, Animal Science, Food Science and Human Nutrition, Michigan State University, East Lansing, MI; 2: Department of Pharmacology and Toxicology, Animal Science, Food Science and Human Nutrition, Michigan State University, East Lansing, MI; 3: Chemoprevention Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; Issue Info: Aug1988, Vol. 48 Issue 2, p298; Thesaurus Term: Bioavailability; Thesaurus Term: HEALTH; Thesaurus Term: Toxicity testing; Subject Term: Medical personnel; Subject Term: Volunteers; Subject Term: Blood plasma; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: bioavailability; Author-Supplied Keyword: high-fat diet; Author-Supplied Keyword: humans; Author-Supplied Keyword: low-fat diet; Author-Supplied Keyword: target concentration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harper, John R.
AU - Greenhalgh, David A.
AU - Yuspa, Stuart H.
T1 - Expression of Transfected DNA by Primary Murine Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1988/08//
VL - 91
IS - 2
M3 - Article
SP - 150
EP - 153
SN - 0022202X
AB - Primary murine keratinocytes can be maintained in culture for extended periods in a proliferative, basal cell state under conditions of reduced extracellular Ca2+ In response to increased Ca2++ concentrations, the cells undergo a well-defined program of terminal differentiation, thus serving as a convenient model in which to study the genes involved in regulating this and possibly other differentiation cascades by DNA- mediated gene transfer. However, because of their sensitivity to increased Ca2++ concentrations, the introduction of exogenous genomic DNA into primary keratinocytes by conventional methods is problematic. We have optimized the calcium phosphate DNA transfection procedure by introducing conditions that reduce the potency of Ca2+ as a differentiation signal. Primary epidermal cells were transfected with pSV2CAT, a plasmid that codes for the enzyme chloramphenicol acetyltransferase CAT. Enzyme activity was measured in cell extracts under varying transfection conditions. When the K+ concentration of the medium used for transfection by calcium phosphate precipitation is reduced from 6.5 to 0.01 mM, CAT activity following transfection increases 2-3 times. Exposure to the DNA precipitate for 2 - 4 h is optimal. By the use of fibroblast conditioned medium following transfection, enzyme activity can be detected in cell extracts for at least 21 d, suggesting that the exogenous gene is integrated. The low K++/Ca2+ transfection method is more effective than SrCl2 used as an alternative for CaC12 in Ca2+ sensitive cells. Low K+ medium enhances cell survival for Ca2+ mediated transfection but also appears to have a beneficial effect on DNA uptake or expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - KERATINOCYTES
KW - CELLS
KW - GENETIC transformation
KW - CALCIUM
KW - ENZYMES
N1 - Accession Number: 12464396; Harper, John R. 1 Greenhalgh, David A. 1 Yuspa, Stuart H. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Aug88, Vol. 91 Issue 2, p150; Subject Term: DNA; Subject Term: KERATINOCYTES; Subject Term: CELLS; Subject Term: GENETIC transformation; Subject Term: CALCIUM; Subject Term: ENZYMES; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12464396
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-05464-038
AN - 2006-05464-038
AU - Chiueh, Chuang C.
T1 - Progress in Histochemistry.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/08//
VL - 33
IS - 8
SP - 702
EP - 703
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05464-038. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Chiueh, Chuang C.; Clinical Brain Imaging Section, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Histology; Neural Development; Neurochemistry; Neurons; Histochemistry. Minor Descriptor: Amino Acids; Central Nervous System; Nervous System; Neuropeptides. Classification: Neuropsychology & Neurology (2520). Population: Human (10). Reviewed Item: Panula, Pertti (Ed); Päivärinta, Heikki (Ed); Soinila, Seppo (Ed). Neurohistochemistry: Modern Methods and Applications=New York: Liss, 1986. 690 pp. $158.00; 1986. Page Count: 2. Issue Publication Date: Aug, 1988.
AB - Reviews the book, Neurohistochemistry: Modern Methods and Applications by Pertti Panula, Heikki Päivärinta, and Seppo Soinila (Eds.) (see record [rid]1986-97935-000[/rid]). This volume summarizes the present state of knowledge concerning newly developed histochemical techniques, as well as their applications on studies of neuronal differentiation. Most of the new information provided here about the distribution of monoaminergic systems, putative amino acid nervous systems, and a coexistence of neuropeptides in the peripheral and central nervous system is not covered in classical textbooks of neuroanatomy. In conclusion, the editors have established a new and exciting direction for neurochemical research, neuron culture for brain transplantation, and chemical brain imaging in both basic and clinical research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - histochemistry
KW - neuronal differentiation
KW - monoaminergic systems
KW - nervous systems
KW - neuropeptides
KW - 1988
KW - Histology
KW - Neural Development
KW - Neurochemistry
KW - Neurons
KW - Histochemistry
KW - Amino Acids
KW - Central Nervous System
KW - Nervous System
KW - Neuropeptides
KW - 1988
U2 - Panula, Pertti (Ed); Päivärinta, Heikki (Ed); Soinila, Seppo (Ed). (1986); Neurohistochemistry: Modern Methods and Applications; New York: Liss, 1986. 690 pp. $158.00; 0-8451-2718-7.
DO - 10.1037/025899
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05464-038&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05464-039
AN - 2006-05464-039
AU - Zahn-Waxier, Carolyn
T1 - Depression: Born or Bred in Children?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/08//
VL - 33
IS - 8
SP - 703
EP - 703
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05464-039. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Zahn-Waxier, Carolyn; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Infant Development; Major Depression; Mother Child Relations; Mothers. Minor Descriptor: Experimental Design. Classification: Affective Disorders (3211). Population: Human (10). Reviewed Item: Tronick, Edward Z. (Ed); Field, Tiffany (Ed). Maternal Depression and Infant Disturbance=San Francisco: Jossey-Bass, 1986. 87 pp. $12.95; 1986. Page Count: 1. Issue Publication Date: Aug, 1988.
AB - Reviews the book, Maternal Depression and Infant Disturbance by Edward Z. Tronick and Tiffany Field (Eds.) (1986). Many mothers experience depression, a condition that cannot help but have a significant impact on relationships with others. The resulting problems for mothers and their young children are considered here. This book identifies methodological problems in existing research (including studies described in this volume) and provides valuable suggestions for new research strategies and designs. These include better measures of functional impairment and depression in mothers and of disorder in children. Some chapters, though well written, are too brief to evaluate the procedures, statistical analyses, and results obtained. Because this is such a new research area, relying sometimes on findings from studies not originally designed to examine maternal depression and infant disturbance, there are inevitable shortcomings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal depression
KW - infant disturbances
KW - research strategies
KW - research designs
KW - 1988
KW - Infant Development
KW - Major Depression
KW - Mother Child Relations
KW - Mothers
KW - Experimental Design
KW - 1988
U2 - Tronick, Edward Z. (Ed); Field, Tiffany (Ed). (1986); Maternal Depression and Infant Disturbance; San Francisco: Jossey-Bass, 1986. 87 pp. $12.95; 1-55542-997-1 (Paperback).
DO - 10.1037/025900
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gentile, Fabrizio
AU - Raptis, Anastassios
AU - Knipling, Leslie G.
AU - Wolff, J.
T1 - Bordetella pertussis adenylate cyclase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/08/15/
VL - 175
IS - 3
M3 - Article
SP - 447
EP - 453
PB - Wiley-Blackwell
SN - 00142956
AB - Exposure of Chinese hamster ovary, mouse adrenal cortex tumor (Y-l), THP-1 and U-937 cells and human erythrocytes to adenylate-cyclase-containing urea extracts of Bordetella pertussis (strain 114) organisms promotes the formation of large concentrations of intracellular cAMP. Accumulation is dependent on dose and temperature, with significant accumulation occurring at 4°C, and is virtually instantaneous, with a doubling at 1 min. There is an absolute Ca2+ requirement but external caimodulin (the activator of cyclase activity) has no effect except in erythrocytes and U-937 cells, where it reduces cAMP accumulation. However, calmodulin antagonists inhibit cAMP accumulation. In Y-I adrenal cells the urea-extract adenylate cyclase stimulates steroidogenesis. Anti-(B. pertussis) antibodies inhibit cyclase activity and prevent further cAMP accumulation after 10 min in cells previously exposed to urea extract. The same effect is obtained by washing. This suggests that a portion of the cyclase is associated with cells in a form not accessible to antibody or washing but accessible to substrate, which we interpret as internalized enzyme with a short lifetime. Continuing cAMP accumulation thus appears to need a continuing source of external cyclase. lnhibitors of the effect of diphtheria toxin, such as NH4Cl, methylamine, chloroquin or monensin, have no inhibitory effect on the accumulation of intracelluar cAMP promoted by the internalized adenylate cyclase of urea extracts of B. pertussis organisms. We conclude that entry of the cyclase into cells is not by receptor-mediated endocytosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA pertussis
KW - ADENYLATE cyclase
KW - CELLS
KW - HAMSTERS
KW - ERYTHROCYTES
KW - ADENYLIC acid
N1 - Accession Number: 13791229; Gentile, Fabrizio 1 Raptis, Anastassios 1 Knipling, Leslie G. 1 Wolff, J. 1; Affiliation: 1: National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda; Source Info: 8/15/88, Vol. 175 Issue 3, p447; Subject Term: BORDETELLA pertussis; Subject Term: ADENYLATE cyclase; Subject Term: CELLS; Subject Term: HAMSTERS; Subject Term: ERYTHROCYTES; Subject Term: ADENYLIC acid; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Albanes, Demetrius
T1 - Three limitations of the body mass index.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/09//
VL - 48
IS - 3
M3 - Letter to the Editor
SP - 691
EP - 692
SN - 00029165
AB - A letter to the editor is presented in response to the article "Three limitations of the body mass index" by Stanley M. Garn, Wiliam R. Leonard and Victor M. Hawthorne in the July 1986 issue.
KW - Body mass index
KW - Body weight
KW - Fat
N1 - Accession Number: 91711340; Micozzi, Marc S. 1; Albanes, Demetrius 2; Affiliations: 1: Armed Forces Institute of Pathology, Washington, DC 20306; 2: National Cancer Institute, Bethesda, MD 20892-4200; Issue Info: Sep1988, Vol. 48 Issue 3, p691; Subject Term: Body mass index; Subject Term: Body weight; Subject Term: Fat; Number of Pages: 2p; Document Type: Letter to the Editor
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Butrum, Ritva R.
AU - Clifford, Carolyn K.
AU - Lanza, Elaine
T1 - NCI dietary guidelines: rationale.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/09//
VL - 48
IS - 3
M3 - Article
SP - 888
EP - 895
SN - 00029165
AB - The National Cancer Institute (NCI) believes that the potential for dietary changes to reduce the risk of cancer is considerable and that the existing scientific data provide evidence that is sufficiently consistent to warrant prudent interim dietary guidelines that will promote good health and reduce the risk of some types of cancer. Six interim dietary guidelines and their scientific rationale are discussed herein. The evidence presented for the scientific rationale is based on the 1982 National Academy of Sciences Committee report Diet, Nutrition and Cancer and NCI's own scientific reviews that link long-term dietary patterns with cancer risk. These guidelines to the American public are consistent with other dietary recommendations from the US departments of Agriculture and Health and Human Services, the American Cancer Society, and the American Heart Association. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Diet
KW - Cancer -- Risk factors
KW - Guidelines
KW - cancer
KW - nutrition
KW - National Cancer Institute (U.S.)
KW - National Academy of Sciences (U.S.)
KW - American Cancer Society Inc.
KW - American Heart Association
N1 - Accession Number: 91711375; Butrum, Ritva R. 1; Clifford, Carolyn K. 1; Lanza, Elaine 1; Affiliations: 1: Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, MD; Issue Info: Sep1988, Vol. 48 Issue 3, p888; Thesaurus Term: Nutrition; Subject Term: Diet; Subject Term: Cancer -- Risk factors; Subject Term: Guidelines; Author-Supplied Keyword: cancer; Author-Supplied Keyword: nutrition ; Company/Entity: National Cancer Institute (U.S.) ; Company/Entity: National Academy of Sciences (U.S.) ; Company/Entity: American Cancer Society Inc. ; Company/Entity: American Heart Association; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Block, Galdys
AU - Bosenberger, William F.
AU - Patterson, Blossom H.
T1 - Calories, Fat and Cholesterol: Intake Patterns in the US Population by Race, Sex and Age.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/09//
VL - 78
IS - 9
M3 - Article
SP - 1150
EP - 1155
PB - American Public Health Association
SN - 00900036
AB - Nutrient intakes were investigated for Blacks and Whites using data from the NHANES II survey (1976-80). Intake of energy, total fat, saturated fat, dietary cholesterol, P/S ratio, and per cent of calories derived from total and saturated fat are examined by sex and age, both in absolute terms and per unit of body weight. For most age and sex categories, Blacks are found to have a lower intake of energy and fats than Whites; however, Blacks have a consistently higher intake of dietary cholesterol. The ratio of polyunsaturated fats to saturated fats is higher in females than in males, but all age-sex groups are substantially below recommended levels. Per cent of calories from total and saturated fat are similar in most age-sex groups. Possible explanations of the observed patterns include activity level and metabolic differences. (Am J Public Health 1988; 78:1150-1155.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION research
KW - DEMOGRAPHIC surveys
KW - PUBLIC health
KW - BLACKS
KW - WHITES
KW - SATURATED fatty acids
KW - CHOLESTEROL
KW - FOOD -- Caloric content
KW - UNITED States
N1 - Accession Number: 4685842; Block, Galdys 1 Bosenberger, William F. 2 Patterson, Blossom H. 3; Affiliation: 1: Surveillance and Operations Research Branch, Division of Cancer Prevention and Control, National Cancer Institute, Executive Plaza No., Rm. 313, Bethesda, MD 20892 2: NCI Division, Rockville, Maryland 3: Information Management Services, Inc., Rockville, Maryland; Source Info: Sep88, Vol. 78 Issue 9, p1150; Subject Term: NUTRITION research; Subject Term: DEMOGRAPHIC surveys; Subject Term: PUBLIC health; Subject Term: BLACKS; Subject Term: WHITES; Subject Term: SATURATED fatty acids; Subject Term: CHOLESTEROL; Subject Term: FOOD -- Caloric content; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brock, Mary Anne
T1 - Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1988/09//Sep/Oct88
VL - 76
IS - 5
M3 - Book Review
SP - 521
EP - 521
SN - 00030996
AB - Reviews the book "Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes," by Eberhard Gwinner.
KW - Biological rhythms
KW - Nonfiction
KW - Gwinner, Eberhard
KW - Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book)
N1 - Accession Number: 11887892; Brock, Mary Anne 1; Affiliations: 1: National Institute of Aging, National Institutes of Health; Issue Info: Sep/Oct88, Vol. 76 Issue 5, p521; Thesaurus Term: Biological rhythms; Subject Term: Nonfiction; Reviews & Products: Circannual Rhythms: Endogenous Annual Clocks in the Organization of Seasonal Processes (Book); People: Gwinner, Eberhard; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Preud'Homme, J. L.
AU - Ganeval, Dominique
AU - GrÜnfeld, J. P.
AU - striker, Liliane
AU - Brouet, J. C.
T1 - Immunoglobulin synthesis in primary and myeloma amyloidosis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1988/09//
VL - 73
IS - 3
M3 - Article
SP - 389
EP - 394
PB - Wiley-Blackwell
SN - 00099104
AB - Bone marrow cells from 14 patients with primary amyloidosis and two patients with myeloma amyloidosis were studied by immunofluorescence and biosynthesis experiments after incorporation of radioactive amino acids. Cells from four patients affected with non-myeloma secondary amyloidosis were also studied as controls. In primary amyloidosis, monoclonal plasma cell populations were demonstrated by immunofluorescence in virtually every case, even in patients without serum and urine monoclonal immunoglobulin and with a normal percentage of bone marrow plasma cells. Biosynthesis experiments showed the secretion of large amounts of free light chains, most often of the &lamda; type, in every primary or myeloma amyloidosis case and the presence of light chain fragments in almost all cases. Special features in certain patients were the synthesis of short γ chains (two cases), assembly block at the HL half molecule level of a monoclonal IgA (one case) and secretion of decameric abnormally large κ chains (one case). This is in contrast with nonmyelomatous secondary amyloidosis where the distribution of bone marrow plasma cells was normal by immunofluorescence and where normal sized immunoglobulins were synthesized, without free light chain secretion and fragments. These data confirm that primary amyloidosis belongs to plasma cell dyscrasias and emphasize the role of free light chains and light chain fragments in the pathogenesis of amyloid deposition 500 IgM nephropathy (IgMN) causes nephrotic syndrome and is characterized by IgM mesangial deposits. It is speculated that these deposits are derived from circulating IgM aggregates or immune complexes, either of which would have a molecular weight heavier than that of normal IgM. To test this hypothesis the sera of 11 patients with IgMN, five patients with nephrotic syndrome of other etiologies, and 13 normal controls were analysed for such heavy IgM. The serum samples were passed over a Biogel A5M molecular sieve column and the fractions were tested for IgM concentration by enzyme linked immunosorbent assay (ELISA). The column effluent from the void volume to the IgM peak was divided into four equal regions, and the average IgM concentrations in each region were compared. The IgMN group had significantly higher IgM concentrations than normal controls in the heaviest region (0.81 ± 0.84 vs. 0.32 ± 0.17 μg/ml; P = 0.01) and in the lightest region (95.8 ± 59.5 vs. 46.3 + 41.2 μg/ml; P = 0.02). Although the IgMN group appeared to have about double the IgM levels of the nephrotic control group in all four regions, this was only significant in the lightest (19S) region. In serum samples from two IgMN patient methods known to break antigen antibody bonds eliminated the heavy IgM; in one case we used gel filtration in potassium thiocyanate and in another ultracentrifugation at pH 2.8. In addition, the heavy IgM in this second patient exhibited complement fixation activity in a sandwich ELISA for IgM-C3 complexes. We conclude that IgMN patients have circulating heavy IgM, which by preliminary studies probably consists of complement fixing IgM immune complexes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMYLOIDOSIS
KW - BONE marrow
KW - LYMPHOPROLIFERATIVE disorders
KW - IMMUNOFLUORESCENCE
KW - SERUM
KW - URINE
KW - immunofluorescence
KW - immunoglobulin synthesis
KW - myeloma
KW - primary amyloidosis
N1 - Accession Number: 16216496; Preud'Homme, J. L. 1 Ganeval, Dominique 2 GrÜnfeld, J. P. 2 striker, Liliane 3 Brouet, J. C. 4; Affiliation: 1: Laboratory of Immunology and Immunopathology, Poitiers University Hospital, Paris. 2: Department of Nephrology, Necker Hospital, Paris. 3: National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. 4: Laboratory of Immunochemistry and Immunopathology, Saint-Louis Hospital, Paris, France.; Source Info: Aug1988, Vol. 73 Issue 3, p389; Subject Term: AMYLOIDOSIS; Subject Term: BONE marrow; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: IMMUNOFLUORESCENCE; Subject Term: SERUM; Subject Term: URINE; Author-Supplied Keyword: immunofluorescence; Author-Supplied Keyword: immunoglobulin synthesis; Author-Supplied Keyword: myeloma; Author-Supplied Keyword: primary amyloidosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barnett, Susan C.
AU - Evans, C. H.
T1 - Leukoregulin-induced translocation of protein kinase C activity in K562 cells.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1988/09//
VL - 73
IS - 3
M3 - Article
SP - 505
EP - 509
PB - Wiley-Blackwell
SN - 00099104
AB - Leukoregulin's effect on biochemical pathways involving Ca2+ was assessed in K562 erythroleukemia cells in which the antitumour lymphokine Induces a rapidly reversible increase in plasma membrane permeability. Leukoregulin exposure activates protein kinase C but does not alter levels of phosphoinositol metabolites, calmodulin or cAMP. The activation pattern of protein kinase C differs from that induced by phorbol myristic acid (PMA), a potent activator of protein kinase C. PMAinduced translocation of protein kinase C from the cytosol to the plasma membrane is maximal by 2 min after addition of PMA whereas after leukoregulin treatment protein kinase C translocation reaches a maximum at 2 h. This suggests that leukoregulin activates protein kinase C via a nonclassical phosphoinositol pathway as opposed to direct binding to protein kinase C as occurs with PMA. The temporal kinetics of the protein kinase C translocation and the increase in membrane permeability induced by leukoregulin are similar suggesting that phosphorylation of a membrane protein may be involved in the target cell destabilization of the plasma membrane by this lymphokine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEUKEMIA
KW - LYMPHOKINES
KW - PROTEIN kinase C
KW - LYMPHOCYTES
KW - CANCER
KW - CELL membranes
KW - leukoregulin
KW - lymphokine
KW - phosophoinositides
KW - protein kinase C
N1 - Accession Number: 16216845; Barnett, Susan C. 1 Evans, C. H. 1; Affiliation: 1: Tumor Biology Section, Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute. Bethesda, Maryland, 20892, USA.; Source Info: Aug1988, Vol. 73 Issue 3, p505; Subject Term: LEUKEMIA; Subject Term: LYMPHOKINES; Subject Term: PROTEIN kinase C; Subject Term: LYMPHOCYTES; Subject Term: CANCER; Subject Term: CELL membranes; Author-Supplied Keyword: leukoregulin; Author-Supplied Keyword: lymphokine; Author-Supplied Keyword: phosophoinositides; Author-Supplied Keyword: protein kinase C; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Platt, Mark W.
AU - Rottem, Shlomo
AU - Milner, Yoram
AU - Barile, Michael F.
AU - Peterkofsky, Alan
AU - Reizer, Jonathan
T1 - Protein phosphorylation in Mycoplasma gallisepticum.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/09//9/1/88
VL - 176
IS - 1
M3 - Article
SP - 62
EP - 67
PB - Wiley-Blackwell
SN - 00142956
AB - Incubation of the soluble fraction derived from Mycoplasma gallisepticum cells with [γ-32P]ATP results in the phosphorylation of several endogenous proteins. One protein with an apparent molecular mass of 55 kDa was the acceptor of more than 95% of the radioactive phosphate. This protein was also found to be radiolabeled in intact cells grown in the presence of [32P]orthophosphate. Acid hydrolysis of the phosphorylated 55-kDa protein followed by two-dimensional electrophoresis revealed that the 32P-labeled material co-migrated with phosphoserine. The in vitro phosphorylation of the 55-kDa protein has an optimum pH of 5.5-6.0 and is not affected by various metabolites of glycolysis, by cAMP or by calmodulin with or without Ca2+. The phosphorylation is dependent upon divalent cations, a dependency that is best fulfilled by the simultaneous addition of Ca2+ and Zn2+ that act in a specific and cooperative manner. Of a variety of possible exogenous protein acceptors tested, the endogenous protein kinase was capable to phosphorylate only phosvitin. The phosphorylation of the 55-kDa protein is reversible through the activity of a phosphoprotein phosphatase present in the soluble fraction of M. gallisepticum. The phosphoprotein phosphatase has an optimum pH of 7.5 -8.0, is inhibited by NaF and stimulated to a large extent by inorganic phosphate and arsenate and to a lesser extent by pyrophosphate ATP and ADP. The possible association of the reversible protein phosphorylation to cell shape and gliding motility of M. gallisepticum are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinases
KW - PHOSPHORYLATION
KW - HYDROGEN-ion concentration
KW - CELL morphology
KW - PHASE partition
KW - ELECTROPHORESIS
KW - CHEMICAL reactions
N1 - Accession Number: 15818680; Platt, Mark W. 1 Rottem, Shlomo 1 Milner, Yoram 2 Barile, Michael F. 3 Peterkofsky, Alan 4 Reizer, Jonathan 4; Affiliation: 1: Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School, Jerusalem. 2: Department of Biological Chemistry, The Hebrew University, Jerusalem. 3: Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland. 4: National Heart, Lung, and Blood Institute, Bethesda, Maryland; Source Info: 9/1/88, Vol. 176 Issue 1, p62; Subject Term: PROTEIN kinases; Subject Term: PHOSPHORYLATION; Subject Term: HYDROGEN-ion concentration; Subject Term: CELL morphology; Subject Term: PHASE partition; Subject Term: ELECTROPHORESIS; Subject Term: CHEMICAL reactions; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Nutt, David
AU - Ravitz, Bernard
AU - Risher-Flowers, Debra
T1 - Binge Use of Benzodiazepines.
JO - Human Psychopharmacology: Clinical & Experimental
JF - Human Psychopharmacology: Clinical & Experimental
Y1 - 1988/09//
VL - 3
IS - 3
M3 - Letter
SP - 227
EP - 227
PB - John Wiley & Sons, Inc.
SN - 08856222
AB - Presents a letter to the editor discussing binge use of benzodiazepines, published in September 1, 1988 issue of the journal "Human Psychopharmacology."
KW - LETTERS to the editor
KW - BENZODIAZEPINES
N1 - Accession Number: 12371616; Nutt, David 1 Ravitz, Bernard 1 Risher-Flowers, Debra 1; Affiliation: 1: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism DICBR, 9000 Rockville Pike, Bethesda. MD 20892, USA.; Source Info: Sep88, Vol. 3 Issue 3, p227; Subject Term: LETTERS to the editor; Subject Term: BENZODIAZEPINES; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr., Paul T.
T1 - Psychological Resilience Among Widowed Men and Women: A 10-Year Follow-up of a National Sample.
JO - Journal of Social Issues
JF - Journal of Social Issues
Y1 - 1988///Fall1988
VL - 44
IS - 3
M3 - Article
SP - 129
EP - 142
SN - 00224537
AB - Uses data from the National Health and Nutrition Examination Survey Epidemiologic Followup Study to examine some long-term consequences of widowhood. Beginning with a sample of over 14,000 respondents between the ages of 25 to 74, a 10-year follow-up traced 94% of those initially married and 93% of the widowed. There were no differences between these groups in mortality rate when adjusted for age and education differences. The authors then compare three groups - those married at both times, those widowed during the follow-up interval, and those widowed at both times - on measures of psychosocial status and functioning at the time of the follow-up. They also analyze subsamples with data on the same variables at initial survey and follow-up. The widowed had lower family income and were more likely to have been institutionalized. However, they showed little or no difference on measures of self-rated health, activities of daily living, social network size, extraversion, openness to experience, psychological well-being, and depression. These results highlight the psychological resilience of most individuals and their capacity to adapt to stressful events and conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Social Issues is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - SOCIAL indicators
KW - SOCIAL networks
KW - LIFE change events
KW - SURVEYS
KW - WIDOWHOOD
KW - PSYCHOLOGY
KW - UNITED States
N1 - Accession Number: 16464784; McCrae, Robert R. 1; Costa Jr., Paul T. 1; Affiliations: 1 : National Institute on Aging.; Source Info: Fall1988, Vol. 44 Issue 3, p129; Historical Period: 1971 to 1975; Subject Term: MORTALITY; Subject Term: SOCIAL indicators; Subject Term: SOCIAL networks; Subject Term: LIFE change events; Subject Term: SURVEYS; Subject Term: WIDOWHOOD; Subject Term: PSYCHOLOGY; Subject: UNITED States; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Dinse, Gregg E.
T1 - Simple Parametric Analysis of Animal Tumorigenicity Data.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1988/09//
VL - 83
IS - 403
M3 - Article
SP - 638
SN - 01621459
AB - The usual onset/death model for tumorigenicity data can be characterized by the tumor incidence rate and the conditional death rates for tumor-free and tumor-bearing animals. If the tumor is unobservable in live animals, however, these rates are difficult to estimate without cause-of-death data or numerous sacrifices. This article proposes simple but flexible parametric models for another set of functions that can be estimated directly from survival/sacrifice data. These estimates can be transformed to obtain estimates of and suggest parametric models for other functions of interest, such as the tumor incidence rate, the conditional death rates, and the relative risk. No cause-of-death data are needed and, due to its parametric nature, the analysis requires few sacrifice times. This approach makes no assumptions about the degree of tumor lethality, nor is the tumor assumed to operate independently of other diseases. The huge ED[sub 01] study provides an excellent basis for assessing the proposed parametric approach. This unique experiment involved approximately 24,000 mice and incorporated 8 interim sacrifices at times ranging from 9 to 24 months. A known carcinogen, 2-acetylaminofluorene, was administered at various doses. The chemical affected survival only at the highest dose and had no effect on four of the six tumors investigated: uterine polyps, lung tumors, reticulum cell sarcomas, and lymphomas. A large subset of the ED[sub 01] data was formed by pooling the mice from all but the highest-dose group. This collection of nearly 20,000 mice is used to demonstrate the appropriateness of the assumed parametric models; the parametric estimates of overall survival, tumor prevalence, and tumor incidence are consistent with the nonparametric estimates. Because the mice were... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - STATISTICS
KW - CARCINOGENESIS
KW - BIOLOGICAL assay
KW - PATHOLOGY
KW - TUMORS
KW - MORTALITY
KW - LYMPHOMAS
KW - Carcinogenesis bioassay
KW - ED01 study
KW - Incidence
KW - Lethality
KW - Prevalence
KW - Survival/sacrifice experiment.
N1 - Accession Number: 4612938; Dinse, Gregg E. 1; Affiliations: 1: Mathematical Statistician, Division of Biometry and Risk Assessment, B3-02, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709.; Issue Info: Sep88, Vol. 83 Issue 403, p638; Thesaurus Term: ESTIMATION theory; Thesaurus Term: STATISTICS; Subject Term: CARCINOGENESIS; Subject Term: BIOLOGICAL assay; Subject Term: PATHOLOGY; Subject Term: TUMORS; Subject Term: MORTALITY; Subject Term: LYMPHOMAS; Author-Supplied Keyword: Carcinogenesis bioassay; Author-Supplied Keyword: ED01 study; Author-Supplied Keyword: Incidence; Author-Supplied Keyword: Lethality; Author-Supplied Keyword: Prevalence; Author-Supplied Keyword: Survival/sacrifice experiment.; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - WOLFFE, ALAN P.
AU - BROWN, DONALD D.
T1 - Developmental Regulation of Two 5S Ribosomal RNA Genes.
JO - Science
JF - Science
Y1 - 1988/09/23/
VL - 241
IS - 4873
M3 - Article
SP - 1626
EP - 1632
SN - 00368075
AB - The developmental regulation oftwo kinds ofXenopus 5S RNA genes (oocyte and somatic types) can be explained by differences in the stability of protein-protein and protein-DNA interactions in a transcription complex that directs transcription initiation by RNA polymerase III. Dissociation oftranscription factors from oocyte 5S RNA genes during development allows them to be repressed by chromatin assembly. In the same cells, somatic 5S RNA genes remain active because their transcription complexes are stable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87461422; WOLFFE, ALAN P. 1,2 BROWN, DONALD D. 1; Affiliation: 1: Department of Embryology at the Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210 2: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 9/23/1988, Vol. 241 Issue 4873, p1626; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Brown, Ellen D.
AU - Taylor, Philip R.
AU - Wolfe, Elaine
T1 - Carotenodermia in men with elevated carotenoid intake from foods and β-carotene supplements.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/10//
VL - 48
IS - 4
M3 - Article
SP - 1061
EP - 1064
SN - 00029165
AB - We evaluated the relation between plasma levels of carotenoids and carotenodermia in 30 men receiving carotenoid supplementation for 42 d. Five subjects each were randomly assigned to one of six treatment groups: 30 mg purified β-carotene supplement, 12 mg β-carotene supplement, 272 g cooked carrots, 300 g cooked broccoli, 180 g tomato juice, and placebo. Definite carotenodermia was observed only in the five subjects who took 30 mg of purified β-carotene daily. Carotenodermia was first noted between 25 and 42 d after supplementation and persisted from 14 to > 42 d posttreatment and was observed only after plasma total carotenoid levels exceeded 4.0 mg/L. These observations may be useful to investigators planning clinical trials with β-carotene and to clinicians assessing the significance of carotenodermia in men taking fl-carotene supplements or following diets high in carotenoid-containing foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Carotenoids
KW - Carotenes
KW - Broccoli
KW - Tomato juice
KW - Clinical trials
KW - β-carotene
KW - Carotenodermia
KW - carotenoids
KW - foods
KW - supplements
N1 - Accession Number: 91711391; Micozzi, Marc S. 1; Brown, Ellen D. 2; Taylor, Philip R. 3; Wolfe, Elaine 4; Affiliations: 1: Medical Museum, Armed Forces Institute of Pathology, Washington, DC; 2: Vitamin and Mineral Nutrition Laboratory, US Department of Agriculture, Beltsville, MD; 3: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; 4: Information Management Services, Inc, Silver Spring, MD; Issue Info: Oct1988, Vol. 48 Issue 4, p1061; Thesaurus Term: Dietary supplements; Subject Term: Carotenoids; Subject Term: Carotenes; Subject Term: Broccoli; Subject Term: Tomato juice; Subject Term: Clinical trials; Author-Supplied Keyword: β-carotene; Author-Supplied Keyword: Carotenodermia; Author-Supplied Keyword: carotenoids; Author-Supplied Keyword: foods; Author-Supplied Keyword: supplements; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pescovitz, M. D.
AU - Lowman, M. A.
AU - Sachs, D. H.
T1 - Expression of T-cell associated antigens by porcine natural killer cells.
JO - Immunology
JF - Immunology
Y1 - 1988/10//
VL - 65
IS - 2
M3 - Article
SP - 267
EP - 271
PB - Wiley-Blackwell
SN - 00192805
AB - We have examined the cell surface phenotype of porcine natural killer (NK) cells and compared them with classic porcine cytotoxic T lymphocytes (CTL). NK cells were susceptible to treatment with monoclonal antibodies to CD2 (PTI 1), CD8 (PT8) and Ia plus complement (C), as well as with antiserum to asialo-GM 1 (ASGM 1) plus C. In addition, monoclonal antibodies to leucocyte function antigen I (LFA-1) but not to CD8 blocked NK-mediated lysis in the absence of C. This is in contrast to porcine CTL, which were eliminated by antibodies to CD2, CD8 and Ia plus C, but not by antis ASGMI plus C, and which were blocked by anti-CD8 in the absence of C. Therefore, although porcine NK cells arc similar to porcine CTL, they are distinguished by several important differences. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - KILLER cells
KW - ANTIGENS
KW - T cells
KW - GENE expression
KW - GENETICS
N1 - Accession Number: 14004312; Pescovitz, M. D. 1 Lowman, M. A. 2 Sachs, D. H. 2; Affiliation: 1: Dept. of Surgery, Indiana University, UHC43O, Indianapolis, IN 76223, U.S.A. 2: Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Oct88, Vol. 65 Issue 2, p267; Subject Term: IMMUNOGLOBULINS; Subject Term: KILLER cells; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: GENE expression; Subject Term: GENETICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Behrman, Jere R.
AU - Deolalikar, Anil B.
AU - Wolfe, Barbara L.
T1 - Nutrients: Impacts and Determinants.
JO - World Bank Economic Review
JF - World Bank Economic Review
Y1 - 1988/10//
VL - 2
IS - 3
M3 - Article
SP - 299
EP - 320
N1 - Accession Number: 55992680; Behrman, Jere R. 1; Deolalikar, Anil B. 1; Wolfe, Barbara L. 1; Affiliations: 1: Jere R. Behrman is a professor of economics at the University of Pennsylvania. Anil B. Deolalikar is a visiting associate professor of economics at Harvard University. Barbara L. Wolfe is an associate professor of economics and preventive medicine at the University of Wisconsin-Madison. They thank the Population Council Research Program on Fertility Determinants, funded by the U.S. Agency for International Development, the U.S. National Science Foundation, and the U.S. National Institutes of Health for research support for the underlying studies.; Issue Info: Oct1988, Vol. 2 Issue 3, p299; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Edelman, Robert
T1 - Food Allergy.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/11//
VL - 48
IS - 5
M3 - Book Review
SP - 1346
EP - 1346
SN - 00029165
KW - Food allergy
KW - Nonfiction
KW - Chandra, R. K.
KW - Food Allergy (Book)
N1 - Accession Number: 91712365; Edelman, Robert 1; Affiliations: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Issue Info: Nov1988, Vol. 48 Issue 5, p1346; Thesaurus Term: Food allergy; Subject Term: Nonfiction; Reviews & Products: Food Allergy (Book); People: Chandra, R. K.; Number of Pages: 1p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Siscovick, David S.
AU - Lars G. Ekelund
AU - Hyde, John S.
AU - Johnson, Jeffrey L.
AU - Gordon, David J.
AU - LaRosa, Joun C.
T1 - Physical Activity and Coronary Heart Disease among Asymptomatic Hypercholesteroleimc Men.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/11//
VL - 78
IS - 11
M3 - Article
SP - 1428
PB - American Public Health Association
SN - 00900036
AB - Abstract: We examined the relation between reported regular strenuous exercise or hard physical labor and the incidence of coronary heart disease (CHD) death and nonfatal myocardial infarction among 1,533 hypercholesterolemic men aged 35-59 years who were in the placebo group of the Lipid Research Clinics Coronary Primary Prevention Trial. The mean follow-up of the cohort was 7.4 years. The men were free of clinical heart disease at entry; men with an abnormal resting electrocardiogram or graded exercise test also were excluded. Regular physical activity was not associated with the incidence of CHD (RR = .94, 95% CI = .68, 1.38) in this study population. Adjustment by the proportional hazards model for age, low-density lipoprotein cholesterol, smoking, family history of CHD, and occupation did not alter this finding. This observation suggests that reported regular physical activity may not be related to the risk of coronary heart disease among asymptomatic, hypercholesterolemic, middle-aged men. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXERCISE
KW - HEALTH behavior
KW - CORONARY heart disease
KW - MYOCARDIAL infarction
KW - HYPERCHOLESTEREMIA
KW - BLOOD cholesterol
KW - ELECTROCARDIOGRAPHY
KW - HEART diseases -- Diagnosis
KW - PHYSICAL fitness
N1 - Accession Number: 4688595; Siscovick, David S. 1 Lars G. Ekelund 1 Hyde, John S. 2 Johnson, Jeffrey L. 1 Gordon, David J. 3 LaRosa, Joun C. 4,5; Affiliation: 1: Collaborative Studies Coordinating Center, Departments of Epidemiology and Biostatistics, University of North Carolina 2: Department of Pathology George Washington University 3: Lipid Research Clinic. Department of Medicine, GWU 4: National Heart, Lung and Blood Institute, Lipid Metabolism-Atherogenesis Branch 5: Departments of Epidemiology and Medicine at the University of Washington, Seattle; Source Info: Nov88, Vol. 78 Issue 11, p1428; Subject Term: EXERCISE; Subject Term: HEALTH behavior; Subject Term: CORONARY heart disease; Subject Term: MYOCARDIAL infarction; Subject Term: HYPERCHOLESTEREMIA; Subject Term: BLOOD cholesterol; Subject Term: ELECTROCARDIOGRAPHY; Subject Term: HEART diseases -- Diagnosis; Subject Term: PHYSICAL fitness; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collman, Gwen W.
AU - Shore, Daved L.
AU - Shy, Carl M.
AU - Checkoway, Harvey
AU - Luria, Alan S.
T1 - Sunlight and Other Risk Factors for Cataracts: An Epidemiologic study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/11//
VL - 78
IS - 11
M3 - Article
SP - 1459
PB - American Public Health Association
SN - 00900036
AB - Abstract: A case control study was conducted in North Carolina to explore the relation between individual exposure to sunlight and the risk of cataracts. One hundred thirteen cases and 161 controls aged 40-69 at diagnosis were studied. Sunlight exposure was inferred from interview data on residency and time spent in the sun, combined with solar radiation data from the National Climatic Data Center. Sunlight exposure was very slightly related to all types of opacities combined. Although the numbers of cases with each type of opacity was small, the risk of cataracts was slightly increased in medium and high exposure categories for persons having cortical or posterior subcapsular opacities only, but not nuclear sclerotic changes. Persons with dark brown or hazel eyes are at increased risk. An unexpected finding was that persons who reported using tranquilizers for six months were at increased risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATARACT
KW - CRYSTALLINE lens -- Diseases
KW - SOLAR radiation
KW - OPACITY (Optics)
KW - LIGHT absorption
KW - EPIDEMIOLOGY
KW - DISEASES -- Causes & theories of causation
KW - PUBLIC health research
KW - VISION
KW - OLD age
N1 - Accession Number: 4690791; Collman, Gwen W. 1 Shore, Daved L. 2 Shy, Carl M. 3 Checkoway, Harvey 4 Luria, Alan S. 5; Affiliation: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park. NC 22709 2: Branch at NIEHS 3: Department of Epidemiology, UNC School of Public Health 4: Department of Environmental Health, School of Public Health, University of Washington, Seattle 5: Asheboro Ophthalmology Associates, Inc., Asheboro, NC; Source Info: Nov88, Vol. 78 Issue 11, p1459; Subject Term: CATARACT; Subject Term: CRYSTALLINE lens -- Diseases; Subject Term: SOLAR radiation; Subject Term: OPACITY (Optics); Subject Term: LIGHT absorption; Subject Term: EPIDEMIOLOGY; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: PUBLIC health research; Subject Term: VISION; Subject Term: OLD age; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martin, George R.
T1 - Developmental Biology, A Comprehensive Synthesis, Vol. 3: The Cell Surface in Development and Cancer (Book).
JO - American Scientist
JF - American Scientist
Y1 - 1988/11//Nov/Dec88
VL - 76
IS - 6
M3 - Book Review
SP - 618
EP - 618
SN - 00030996
AB - Reviews the book "Developmental Biology, A Comprehensive Synthesis, Vol. 3: The Cell Surface in Development and Cancer," edited by Malcolm Steinberg.
KW - Developmental biology
KW - Nonfiction
KW - Steinberg, Malcolm
KW - Developmental Biology: A Comprehensive Synthesis: The Cell Surface in Development & Cancer (Book)
N1 - Accession Number: 11757118; Martin, George R. 1; Affiliations: 1: National Institutes of Health, Bethesda; Issue Info: Nov/Dec88, Vol. 76 Issue 6, p618; Thesaurus Term: Developmental biology; Subject Term: Nonfiction; Reviews & Products: Developmental Biology: A Comprehensive Synthesis: The Cell Surface in Development & Cancer (Book); People: Steinberg, Malcolm; Number of Pages: 1/4p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yanagishita, Machiko
AU - Guralnik, Jack M.
T1 - Changing Mortality Patterns That Led Life Expectancy in Japan to Surpass Sweden's: 1972-1982.
JO - Demography
JF - Demography
Y1 - 1988/11//
VL - 25
IS - 4
M3 - Article
SP - 611
EP - 624
SN - 00703370
AB - Between 1972 and 1982, Japan caught up to and then surpassed Sweden as the country with the longest life expectancy. The contributions of different causes of death and age groups to life expectancy changes in males during this time period are examined in detail for these two countries. Even though cerebrovascular disease mortality rates remained lower in Sweden over the entire interval, the rapid gain made by Japan relative to Sweden for this cause of death was a prime factor in Japan's ending the period with a higher life expectancy. Important contributions to life expectancy improvement in Japan came from declining mortality rates in those aged 55 and older. [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - LONGEVITY
KW - QUALITY of life
KW - OLD age
KW - SOCIAL indicators
KW - AGE groups
N1 - Accession Number: 16799696; Yanagishita, Machiko 1; Guralnik, Jack M. 1; Affiliations: 1: Epidemiology, Biometry, and Demography Program, National Institute on Aging, 7550 Wisconsin Avenue, Bethesda, Maryland 20892; Issue Info: Nov1988, Vol. 25 Issue 4, p611; Subject Term: MORTALITY; Subject Term: LONGEVITY; Subject Term: QUALITY of life; Subject Term: OLD age; Subject Term: SOCIAL indicators; Subject Term: AGE groups; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Smith, C. A. D.
AU - Louis, M. J.
AU - Hetrick, F. M.
T1 - A sequence homologous to the mammalian p53 oncogene in fish cell lines.
JO - Journal of Fish Diseases
JF - Journal of Fish Diseases
Y1 - 1988/11//
VL - 11
IS - 6
M3 - Article
SP - 525
EP - 530
PB - Wiley-Blackwell
SN - 01407775
AB - This article presents a study of a sequence homologous to the mammalian p53 oncogene in fish cell lines. The p53 protein is species-specific and appears conserved through evolution in mammals. The widespread occurrence of neoplasia in fish and the need to describe the evolutionary development and diversity of proto-oncogene sequences, make the study of genes homologous to those of the mammalian proto-oncogenes important in understanding tumour formation in lower vertebrates and higher animals. The results give preliminary, yet clear, evidence for the presence of a p53-like sequence in the EPC and CHSE-214 cell lines thus extending the knowledge of the evolutionary range of the p53 gene to fish.
KW - FISHES
KW - CELL culture
KW - CELL lines
KW - TUMORS
KW - MAMMALS
KW - ANTIONCOGENES
N1 - Accession Number: 15408729; Smith, C. A. D. 1 Louis, M. J. 1 Hetrick, F. M. 2; Affiliation: 1: Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA. 2: Department of Microbiology, University of Maryland, USA.; Source Info: Nov1988, Vol. 11 Issue 6, p525; Subject Term: FISHES; Subject Term: CELL culture; Subject Term: CELL lines; Subject Term: TUMORS; Subject Term: MAMMALS; Subject Term: ANTIONCOGENES; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van der Ley, P.
T1 - Three copies of a single protein ll-encoding sequence in the genome of Neisseria gonorrhoeae JS3: evidence for gene conversion and gene duplication.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1988/11//
VL - 2
IS - 6
M3 - Article
SP - 797
EP - 806
PB - Wiley-Blackwell
SN - 0950382X
AB - Gonococci express a family of related outer membrane proteins designated protein II (P.II). These surface proteins are subject to both phase variation and antigenic variation. The P.II gene repertoire of Neisseria gonorrhoeae strain JS3 was found to consist of at least ten genes, eight of which were cloned. Sequence analysis and DNA hybridization studies revealed that one particular P.II-encoding sequence is present in three distinct, but almost identical, copies in the JS3 genome. These genes encode the P.II protein that was previously identified as P.IIc. Comparison of their sequences shows that the multiple copies of this P.IIc-encoding gene might have been generated by both gene conversion and gene duplication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hybridization
KW - Neisseria gonorrhoeae
KW - Membrane proteins
KW - Genes
KW - Antigenic determinants
KW - Microbial genomes
KW - Microbial genetics
N1 - Accession Number: 18278442; van der Ley, P. 1,2; Affiliations: 1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA; 2: National Institute of Public Health and Environmental Hygiene, PO Box 1, 3720 BA Bilthoven, The Netherlands; Issue Info: Nov1988, Vol. 2 Issue 6, p797; Thesaurus Term: Hybridization; Subject Term: Neisseria gonorrhoeae; Subject Term: Membrane proteins; Subject Term: Genes; Subject Term: Antigenic determinants; Subject Term: Microbial genomes; Subject Term: Microbial genetics; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Looker, Anne C.
AU - Johnson, Clifford L.
AU - Underwood, Barbara A.
T1 - Serum retinol levels of persons aged 4-74 years from three Hispanic groups.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/12//
VL - 48
IS - 6
M3 - Article
SP - 1490
EP - 1496
SN - 00029165
AB - Previous research suggests that Hispanics in this country may have poor vitamin A status. Using serum retinol data from the Hispanic Health and Nutrition Examination Survey, we examined the vitamin A status of Mexican Americans (MA), Cubans, and Puerto Ricans (PR) aged 4-74 y. MA had lower mean serum retinol levels and higher prevalences of serum retinol in the range 0.70-1.01 µmol/L than did Cubans in several age-sex groups. The prevalence (or percentage) of serum retinol in a range indicating possible risk of functional impairment was not elevated in any of the Hispanic groups except the females aged 18-44 y. However, a high percentage of children and adolescents in the three Hispanic groups had serum retinol values in ranges that might indicate less-than-optimal vitamin A status. Determination of vitamin A status requires a more definitive assessment than by serum vitamin A alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vitamin A
KW - Mexican Americans
KW - Cubans
KW - Hispanic Americans
KW - Age groups
KW - Children
KW - Ethnic groups
KW - nutrition surveys
KW - vitamin A
N1 - Accession Number: 91711440; Looker, Anne C. 1; Johnson, Clifford L. 1; Underwood, Barbara A. 1; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville and the National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Dec1988, Vol. 48 Issue 6, p1490; Subject Term: Vitamin A; Subject Term: Mexican Americans; Subject Term: Cubans; Subject Term: Hispanic Americans; Subject Term: Age groups; Subject Term: Children; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: nutrition surveys; Author-Supplied Keyword: vitamin A; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lambert, Paul F.
AU - Baker, Carl C.
AU - Howley, Peter M.
T1 - THE GENETICS OF BOVINE PAPILLOMAVIRUS TYPE 1.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1988/12//
VL - 22
M3 - Article
SP - 235
EP - 258
PB - Annual Reviews Inc.
SN - 00664197
AB - Investigates the genetics of bovine papillomavirus type 1 (BPV-1). Nature of papillomaviruses; Association of BPV-1 with cutaneous fibropapillomas in cattle; Structure of the BPV-1 genome; Transcription of the BPV-1 genome.
KW - PAPILLOMAVIRUSES
KW - CATTLE
KW - VIRUSES
KW - VIRAL genetics
KW - MICROBIAL genetics
KW - BIOCHEMICAL genetics
KW - MOLECULAR genetics
KW - MOLECULAR biology
N1 - Accession Number: 17740512; Lambert, Paul F. 1 Baker, Carl C. 1 Howley, Peter M. 1; Affiliation: 1: Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892; Source Info: 1988, Vol. 22, p235; Subject Term: PAPILLOMAVIRUSES; Subject Term: CATTLE; Subject Term: VIRUSES; Subject Term: VIRAL genetics; Subject Term: MICROBIAL genetics; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scriver, Charles R.
AU - Kaufman, Seymour
AU - Woo, Savio L. C.
T1 - MENDELIAN HYPERPHENYLALANINEMIA.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1988/12//
VL - 22
M3 - Article
SP - 301
EP - 321
PB - Annual Reviews Inc.
SN - 00664197
AB - Examines aspects of the Mendelian hyperphenylalaninemias in man. Recognition of phenylalanine as an essential amino acid in humans; Components of the hydroxylation reaction; Putative mechanism of the deviant gene dosage effect.
KW - PHENYLALANINE
KW - AMINO acids
KW - HUMAN genetics
KW - GENETIC research
KW - BIOCHEMICAL genetics
KW - MOLECULAR genetics
KW - MOLECULAR biology
N1 - Accession Number: 17740547; Scriver, Charles R. 1 Kaufman, Seymour 2 Woo, Savio L. C. 3; Affiliation: 1: The Centre for Human Genetics, McGill University and The deBelle Laboratory, Division of Medical Genetics, McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3 2: National Institutes of Health, Laboratory for Neurochemistry, Building 36, Room 3D3O, Bethesda, Maryland 20014 3: Howard Hughes Medical Institute, Baylor College of Medicine, I Baylor Plaza, M905, Houston, Texas 77030; Source Info: 1988, Vol. 22, p301; Subject Term: PHENYLALANINE; Subject Term: AMINO acids; Subject Term: HUMAN genetics; Subject Term: GENETIC research; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Brien, Stephen J.
AU - Seuánez, Héctor N.
AU - Womack, James E.
T1 - MAMMALIAN GENOME ORGANIZATION: AN EVOLUTIONARY VIEW.
JO - Annual Review of Genetics
JF - Annual Review of Genetics
Y1 - 1988/12//
VL - 22
M3 - Article
SP - 323
EP - 351
PB - Annual Reviews Inc.
SN - 00664197
AB - Provides an overview of the state of comparative genetics in mammals. Development of animal models of human inborn errors; Complexities of mammalian immune gene complexes; Application of hybrid somatic cells to gene mapping.
KW - GENETIC research
KW - ANIMAL models in research
KW - BIOCHEMICAL genetics
KW - MOLECULAR genetics
KW - MOLECULAR biology
N1 - Accession Number: 17740551; O'Brien, Stephen J. 1 Seuánez, Héctor N. 1 Womack, James E. 2; Affiliation: 1: Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701-1013 2: Department of Veterinary Pathology, Texas A&M University, College Station, Texas 77843; Source Info: 1988, Vol. 22, p323; Subject Term: GENETIC research; Subject Term: ANIMAL models in research; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: MOLECULAR biology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 29p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Washington, R.;
AU - Farinas, E.;
AU - Gallelli, J. F.;
T1 - ANALYSIS OF PATIENT MEDICATION AWARENESS IN A NEUROLOGY OUTPATIENT CLINIC
CT - ANALYSIS OF PATIENT MEDICATION AWARENESS IN A NEUROLOGY OUTPATIENT CLINIC
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1988/12/01/
VL - 23
IS - Dec
SP - P
EP - 9
AD - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892
N1 - Accession Number: 26-03538; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education
N2 - The medication knowledge of epileptic outpatients was assessed. Questionnaires were distributed during clinic sessions to epileptic outpatients on anticonvulsants whose written or oral communication skills were not impaired or who had a primary caregiver present. Patients were considered to be aware of their medication regimen if they correctly completed five questionnaire items\M/name of medication, color, strength, reasons for use, and directions for use\M/for each of their antiepileptic medications. In order to obtain additional information on contributing factors to patients\PR/ level of awareness, items to help determine (1) the primary source of patients\PR/ medication knowledge, (2) the adequacy of the time spent by the primary teacher on instructing patients, (3) the methods used to communicate the patients\PR/ medication information and (4) the ability of the patient to adhere to his medication regimen independently were included in the questionnaire. Twenty-four epileptic outpatients participated in this analysis. Sixteen (67%) patients were aware of their medication regimen. Eight (33%) patients were unaware of their medication regimen and unable to answer the questionnaire's five chart items with correct or complete information on their anticonvulsants. Factors contributing to patient medication awareness were analyzed and are reported. Pharmacy intervention is probably needed in this clinic since a significant percentage of these outpatients were unaware of their medication regimens. Suggested improvements in the outpatient pharmacy's service of epileptic outpatients could include: (1) more collaboration between the neurology clinic and the outpatient pharmacy in identifying patients who require additional assistance with their medication regimen, (2) the introduction of a requirement that epileptic patients state their medication regimen before their prescription is dispensed, and (3) the education of pharmacists to the special needs of these patients and the methods available to assist these patients in increasing their medication awareness.
KW - Patient education--analysis--awareness evaluation;
KW - Patients--outpatients--medication knowledge;
KW - ASHP meeting abstracts--patient education evaluation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Fleg, Jerome L.
T1 - Ventricular arrhythmias in the elderly: Prevalence, mechanisms, and therapeutic implications.
JO - Geriatrics
JF - Geriatrics
Y1 - 1988/12//
VL - 43
IS - 12
M3 - Article
SP - 23
EP - 29
SN - 0016867X
N1 - Accession Number: 15864367; Fleg, Jerome L. 1; Source Information: Dec1988, Vol. 43 Issue 12, p23; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3296
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 108181449
T1 - Ventricular arrhythmias in the elderly: prevalence, mechanisms, and therapeutic implications.
AU - Fleg, J L
Y1 - 1988/12//
N1 - Accession Number: 108181449. Language: English. Entry Date: 20120504. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985102R.
KW - Aging -- Physiology
KW - Arrhythmia -- Physiopathology
KW - Aged
KW - Antiarrhythmia Agents -- Therapeutic Use
KW - Arrhythmia -- Diagnosis
KW - Arrhythmia -- Therapy
KW - Electrocardiography
KW - Exercise Test
KW - Heart Diseases -- Physiopathology
KW - Heart Ventricle -- Physiopathology
KW - Middle Age
SP - 23
EP - 29
JO - Geriatrics
JF - Geriatrics
JA - GERIATRICS
VL - 43
IS - 12
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
SN - 0016-867X
AD - Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore.
U2 - PMID: 3056779.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lessin, Stuart R.
AU - Huebner, Kay
AU - Isobe, Masaharu
AU - Croce, Carlo M.
AU - Steinert, Peter M.
T1 - Chromosomal Mapping of Human Keratin Genes: Evidence of Non-linkage.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1988/12//
VL - 91
IS - 6
M3 - Article
SP - 572
EP - 578
SN - 0022202X
AB - We have determined the chromosomal location of the genes for the human keratin intermediate filament proteins K1 (type II; 67 kDa) and K10 (type I; 57 kDa) by the use of specific cDNA clones in conjunction with somatic cell hybrid analysis and in situ hybridization. The K1 keratin gene maps to chromosome region 12q11 → q13; the K10 keratin gene maps to chromosome region 17q12 → q21. Each gene has been mapped relative to other genes known to be localized on chromosomes 12 and 17, respectively. In somatic cell hybrid analysis, the K1 gene segregates concordantly with the Hox-3 homeo box gene cluster at chromosome region 12p12 → q13. The K10 gene localizes to a region proximal to a breakpoint at 17q21 which is involved in a t(17;21) (q21;q22) translocation. associated with an acute leukemia. K10 appears to be distal (telomeric) to the gene loci for G-CSF, erb-A, and Her-2, which map to chromosome region 17q12 → q21. The NGFR gene and Hox-2 homeo box locus are localized distal to the 17q21 break point and thus distal to the K10 gene. These data demonstrate that keratin genes K1 and K10, which are coexpressed in terminally differentiated epidermis, are not linked in the human genome, implying the existence of transacting factors involved in the regulation of expression of these genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEREDITY
KW - GENETICS
KW - CELL nuclei
KW - GENES
KW - GENOMES
KW - HUMAN chromosomes
N1 - Accession Number: 12477087; Lessin, Stuart R. 1 Huebner, Kay 2 Isobe, Masaharu 2 Croce, Carlo M. 2 Steinert, Peter M. 3; Affiliation: 1: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. 2: The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania. 3: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Dec88, Vol. 91 Issue 6, p572; Subject Term: HEREDITY; Subject Term: GENETICS; Subject Term: CELL nuclei; Subject Term: GENES; Subject Term: GENOMES; Subject Term: HUMAN chromosomes; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12477087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12477087&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-05468-053
AN - 2006-05468-053
AU - Richters, John
T1 - Perspectives on a Phenomena Lost.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/12//
VL - 33
IS - 12
SP - 1091
EP - 1091
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05468-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Richters, John; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Experimentation; Psychology. Minor Descriptor: Psychologists. Classification: General Psychology (2100). Population: Human (10). Reviewed Item: Valsiner, Jaan (Ed). The Individual Subject and Scientific Psychology=New York: Plenum Press, 1986. 408 pp. $45.00; 1986. Page Count: 1. Issue Publication Date: Dec, 1988.
AB - Reviews the book, The Individual Subject and Scientific Psychology by Jaan Valsiner (Ed.) (1986). Psychologists are socialized through training and practice into a very specialized subculture, narrowly defined by established values, priorities, assumptions, and ways of thinking about things. The issues dealt with in this volume should be of interest and concern to researchers in all areas of psychology. The book may be of particular interest to developmental psychologists because so many of the contributors are themselves developmentalists. But the issues transcend subspecialty boundaries and warrant the attention of anyone concerned with the adequacy-to-phenomena shortcomings of our most widely used methods of design and analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - scientific psychology
KW - research
KW - 1988
KW - Experimentation
KW - Psychology
KW - Psychologists
KW - 1988
U2 - Valsiner, Jaan (Ed). (1986); The Individual Subject and Scientific Psychology; New York: Plenum Press, 1986. 408 pp. $45.00; 0-306-42250-6.
DO - 10.1037/026351
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05468-053&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05468-056
AN - 2006-05468-056
AU - Tabakoff, Boris
T1 - The Inebriation of the Russian Soul.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1988/12//
VL - 33
IS - 12
SP - 1093
EP - 1093
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-05468-056. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tabakoff, Boris; National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Alcohol Drinking Patterns; Alcoholism; History. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: Russia. Reviewed Item: Segal, Boris M. Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia=New Brunswick, NJ: Rutgers Center of Alcohol Studies, 1987. 383 pp. $29.95 hardcover; $19.95 paperback; 1987. Page Count: 1. Issue Publication Date: Dec, 1988.
AB - Reviews the book, Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia by Boris M. Segal (1987). This book is a chronology of Russian drinking customs from the tribal beginnings of the Russian Empire in the pre-Christian era to the time of the demise of the czarist regime at the hands of the Bolsheviks. The author well describes the history of government attitudes toward the consumption of alcohol by the population, as well as the aspects of the Russian culture, such as child rearing practices, that help explain Russian drinking habits. The book, as a whole, provides a satisfying synopsis of history and culture in juxtaposition to the evolution of alcohol consumptive behaviors. The text contains a wealth of information about the history of Russian drinking establishments, Russian concepts of alcoholism, early approaches to treatment and prevention, and even a discourse on prerevolutionary research on alcoholism by Russian scientists (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Russian history
KW - alcoholism
KW - 1988
KW - Alcohol Drinking Patterns
KW - Alcoholism
KW - History
KW - 1988
U2 - Segal, Boris M. (1987); Russian Drinking: Use and Abuse of Alcohol in Pre-Revolutionary Russia; New Brunswick, NJ: Rutgers Center of Alcohol Studies, 1987. 383 pp. $29.95 hardcover; $19.95 paperback; 0-911290-18-4 (Hardcover); 0-911290-19-2 (Paperback).
DO - 10.1037/026354
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05468-056&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - Gen
ID - 9999-25491-000
AN - 9999-25491-000
AU - Krupp, Lauren B.
AU - LaRocca, Nicholas G.
AU - Muir-Nash, Joanne
AU - Steinberg, Alfred D.
T1 - Fatigue Severity Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1989///
AD - Krupp, Lauren B., State University of New York at Stony Brook, School of Medicine, Department of Neurology, Health Sciences Center, Stony Brook, New York, United States, 11794-8121
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1 - Accession Number: 9999-25491-000. Acronyms: FSS. Partial author list: First Author & Affiliation: Krupp, Lauren B.; State University of New York at Stony Brook, Department of Neurology, Stony Brook, New York, United States. Release Date: 20160314. Correction Date: 20160411. Instrument Type: Rating Scale. Test Location: Table 2, Page 1122. Test Format: This 9-item measure utilizes a 7-point scale where 1 indicates 'strongly disagree' and 7, 'strongly agree.'. Language: English. Constructs: Fatigue Severity; Classification: Physical Health/Illness Related Assessment (7300). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300). Other Versions: 9999-29218-000, Fatigue Severity Scale Short Form, Revision.
AB - Purpose: The purpose of the Fatigue Severity Scale is to assess self-reported disabling fatigue in order to facilitate research and patient treatment.
AB - Description: The Fatigue Severity Scale (FSS; Krupp et al., 1989) is a 9-item, Likert-scaled measure of fatigue severity as reported by patients with medical and neurologic disorders. Development of the FSS began with a 28-item fatigue questionnaire, which was administered to patients with multiple sclerosis (MS), patients with systemic lupus erythematosus (SLE), and healthy adult controls. Using factor analysis, item analysis, and theoretical considerations, 9 items from the fatigue questionnaire were selected that identified features of fatigue common to the MS and SLE patient groups (e.g., 'Fatigue interferes with my physical functioning'). Results of analyses revealed that the FSS was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Disabling Fatigue
KW - Discriminative Ability
KW - Fatigue Severity Rating
KW - Fatigue Severity Scale
KW - Internal Consistency
KW - Multiple Sclerosis
KW - Self-Report
KW - Systemic Lupus Erythematosus
KW - Test Development
KW - Test Sensitivity
KW - Test Validity
KW - Test-Retest Reliability
U5 - Fatigue Severity Scale (FSS) [Test Development]The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus. (AN: 2016-03727-001 from PsycINFO) Krupp, Lauren B.; LaRocca, Nicholas G.; Muir-Nash, Joanne; Steinberg, Alfred D.; Oct, 1989. Source: Archives of Neurology. 46(10), American Medical Association, US; Oct, 1989; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Outpatient; Location: United States; Samples: Patients with Multiple Sclerosis; Patients with Systemic Lupus Erythematosus; Healthy Adult Controls Keywords: Disabling Fatigue; Discriminative Ability; Fatigue Severity Rating; Fatigue Severity Scale; Internal Consistency; Multiple Sclerosis; Self-Report; Systemic Lupus Erythematosus; Test Development; Test Sensitivity; Test Validity; Test-Retest Reliability; Subjects: Fatigue; Lupus; Multiple Sclerosis; Physical Health Assessment; Rating Scales; Self-Report; Severity (Disorders); Test Construction; Test Reliability; Test Sensitivity; Test Validity;
DO - 10.1037/t25491-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-25491-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-35126-000
AN - 9999-35126-000
AU - Brott, Thomas
AU - Adams, Harold P. Jr.
AU - Olinger, Charles P.
AU - Marler, John R.
AU - Barsan, William G.
AU - Biller, José
AU - Spilker, Judith
AU - Holleran, Renée
AU - Eberle, Robert
AU - Hertzberg, Vicki
AU - Rorick, Marvin
AU - Moomaw, Charles J.
AU - Walker, Michael
T1 - National Institutes of Health Stroke Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1989///
AD - Brott, Thomas, Department of Neurology, University of Cincinnati Medical Center, 231 Bethesda Avenue, Cincinnati, Ohio, United States, 45267-0525
AV - Commercial: No; Permissions: Contact Publisher and Corresponding Author; Fee: No. Test Items: No
N1 - Accession Number: 9999-35126-000. Other Names: NIH Stroke Scale. Acronyms: NIHSS. Partial author list: First Author & Affiliation: Brott, Thomas; University of Cincinnati, Cincinnati, Ohio, United States. Release Date: 20160411. Correction Date: 20160509. Instrument Type: Rating Scale. Test Location: Figure 1, Page 865. Test Format: The NIHSS contains 15 items rated on 3- and 4-point response scales, with varying anchor statements.. Language: English. Constructs: Cerebral Infarction; Classification: Neuropsychological Assessment (6900). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Other Versions: 9999-47097-000, National Institutes of Health Stroke Scale—Arabic Version, Translation.
N2 - Administration Method: Other
AB - Purpose: The NIHSS is a brief stroke examination that was developed for use in acute stroke therapy trials.
AB - Description: The National Institutes of Health Stroke Scale (NIHSS; Brott et al., 1989) was developed for use in acute stroke therapy trials. The scale contains 15 examination items, rated on 3- and 4-point scales with varying anchor statements. Example examination items include, 'Pupillary response' (0=Both reactive, 1=One reactive, 2=Neither reactive), 'Plantar Reflex' (4-point scale, with 0=Normal, 3=Bilateral extensor), and 'Dysarthria' (3-point scale, 0=normal articulation, 2=Near unintelligible). The examination can be performed quickly, on average less than 7 minutes, by either nurses or physicians. In a study of 24 stroke patients, interrater reliability for the neurologic examination was found to be high (mean Kappa=0.69), and test-retest reliability was also high (mean Kappa=0.66-0.77). The stroke scale validity was assessed by comparing the scale scores obtained prospectively on 65 acute stroke patients to the patients' infarction size as measured by computed tomography scan at 1 week and to the patients' clinical outcome as determined at 3 months. These correlations (scale-lesion size r=0.68, scale-outcome r=0.79) suggested acceptable examination and scale validity. Of the 15 test items, the most interrater reliable item (pupillary response) had low validity. Less reliable items such as upper or lower extremity motor function were more valid. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - National Institutes of Health Stroke Scale
KW - Test Development
KW - Interrater Reliability
KW - Test-Retest Reliability
KW - Test Validity
KW - Acute Cerebral Infarction
U5 - National Institutes of Health Stroke Scale (NIHSS) [Test Development]Measurements of acute cerebral infarction: A clinical examination scale. (AN: 2016-09459-001 from PsycINFO) Brott, Thomas; Adams, Harold P. Jr.; Olinger, Charles P.; Marle, John R.; Barsan, William G.; Biller, José; Spilker, Judith; Holleran, Renée; Eberle, Robert; Hertzberg, Vicki; Rorick, Marvin; Moomaw, Charles J.; Walker, Michael; Jan, 1989. Source: Stroke. 20(7), American Heart Association, US; Jan, 1989; Administration: Other Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Stroke Patients; Location: United States Keywords: National Institutes of Health Stroke Scale; Test Development; Interrater Reliability; Test-Retest Reliability; Test Validity; Acute Cerebral Infarction; Subjects: Cerebrovascular Accidents; Interrater Reliability; Neuropsychological Assessment; Test Construction; Test Reliability; Test Validity;
DO - 10.1037/t35126-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-35126-000&site=ehost-live&scope=site
UR - http://rehabmeasures.org/Lists/RehabMeasures/DispForm.aspx?ID=914
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Biben, Maxeen
AU - Symmes, David
AU - Bernhards, Deborah
T1 - Vigilance During Play in Squirrel Monkeys.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1989/01//
VL - 17
IS - 1
M3 - Article
SP - 41
EP - 49
SN - 02752565
AB - Play by young squirrel monkeys (Saimiri boliviensis) may put them and other troop members at risk for predation because youngsters are noisy, separated from adults, and not vigilant when at play. In a study using separated groups of adults and 1-year-old juveniles caged outdoors, we found that adult female squirrel monkeys become more vigilant during periods of spontaneous play among juveniles. This behavioral response could be obtained with auditory cues (play vocalizations) alone. Five times as much vigilance activity was directed toward an area from which threat or disturbance was likely to come as was directed toward the juveniles themselves. These results suggest both an adaptive, compensatory increase in adult vigilance during play and a function for play vocalizations. Additional functions for play vocalizations remain to be investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SQUIRREL monkeys
KW - BEHAVIOR
KW - SOCIAL behavior in animals
KW - SOUND production by animals
KW - ANIMAL behavior
KW - MONKEYS -- Behavior
KW - PLAY behavior in animals
KW - antipredator behavior
KW - social behavior
KW - vocal behavior
N1 - Accession Number: 12319016; Biben, Maxeen 1 Symmes, David 1 Bernhards, Deborah 1; Affiliation: 1: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development; Source Info: 1989, Vol. 17 Issue 1, p41; Subject Term: SQUIRREL monkeys; Subject Term: BEHAVIOR; Subject Term: SOCIAL behavior in animals; Subject Term: SOUND production by animals; Subject Term: ANIMAL behavior; Subject Term: MONKEYS -- Behavior; Subject Term: PLAY behavior in animals; Author-Supplied Keyword: antipredator behavior; Author-Supplied Keyword: social behavior; Author-Supplied Keyword: vocal behavior; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Carter, Christine L.
AU - Albanes, Demetrius
AU - Taylor, Philip R.
AU - Licitra, Lisa M.
T1 - Bowel Function and Breast Cancer in US Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/01//
VL - 79
IS - 1
M3 - Article
SP - 73
EP - 75
PB - American Public Health Association
SN - 00900036
AB - We studied bowel function in relation to 123 breast cancer cases among 7,702 women from the US NHANES I Epidemiologic Follow-up Study. Results suggest a slight increased risk of breast cancer for both decreased frequency of bowel movements (relative risk = 1.5, 95% confidence interval = 0.8, 2.7) and firm stool consistency (RR = 1.8, 95% CI = 1.0, 3.2.) These observations are consistent with an hypothesized association between constipation and increased risk of breast cancer. (Am J Public Health 1989; 79: 73-75.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer -- Research
KW - INTESTINAL diseases
KW - PUBLIC health
KW - INFLAMMATORY bowel diseases
KW - WOMEN -- Health
KW - CANCER patients
KW - CANCER -- Study & teaching
KW - CANCER in women
KW - UNITED States
N1 - Accession Number: 4685487; Micozzi, Marc S. 1 Carter, Christine L. 2 Albanes, Demetrius 2 Taylor, Philip R. 2 Licitra, Lisa M. 3; Affiliation: 1: Associate Director, armed Forces Institute of Pathology, Washington, DC 20306-6000 2: Cancer Prevention studies Branch, National Cancer Institute, Bethesda, MD 3: Information Management Services Silver Spring MD; Source Info: Jan1989, Vol. 79 Issue 1, p73; Subject Term: BREAST cancer -- Research; Subject Term: INTESTINAL diseases; Subject Term: PUBLIC health; Subject Term: INFLAMMATORY bowel diseases; Subject Term: WOMEN -- Health; Subject Term: CANCER patients; Subject Term: CANCER -- Study & teaching; Subject Term: CANCER in women; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Williams, T. Franklin
AD - National Institutes of Health
A2 - Eisdorfer, Carl
A2 - Kessler, David A.
A2 - Spector, Abby N.
T1 - Approaches to Health
T2 - Caring for the elderly: Reshaping health policy
PB - Johns Hopkins Series in Contemporary Medicine and Public Health
PB - Baltimore and London:
PB - Johns Hopkins University Press
Y1 - 1989///
SP - 482
EP - 489
N1 - Accession Number: 0256433; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 199203
KW - Economics of Health (including medical subsidy programs) 9130
KW - Economics of Aging 9180
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Lal, R. B.
AU - Ottesen, E. A.
T1 - Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/01//
VL - 75
IS - 1
M3 - Article
SP - 52
EP - 57
PB - Wiley-Blackwell
SN - 00099104
AB - Sera from a total of 78 patients infected with Wuchereria bancrofti or appropriate controls were assayed for anti-phosphocholine antibodies in an enzyme-linked immunosorbent-assay (ELISA), using phosphocholine as an antigen, Anti-PC antibodies (both IgM and IgG) were observed in patients with all clinical forms of filariasis but, unexpectedly, were not significantly different from those of normal controls. Among the filariasis patients, however, individuals with patent microfilaraemia had significantly lower IgM-anti-PC titres (P < 0.05) than did those of the other clinical groups. Competitive studies showed that "naturally occurring' anti-PC antibodies interfere with PC antigen detection. Transient increases in the levels of ciruculating PC antigen were found by 3 days after treatment of microfilaraemic individuals with the filaricidal drug diethylcarbamazine. The subsequent decreases in antigen levels were generally associated with increased IgM- and IgG-anti- PC antibody levels. Such changes likely affect not only the ability to monitor the parasitological status of such individuals, but also the patient's subsequent immune interactions with filarial parasites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ENZYME-linked immunosorbent assay
KW - ANTIGENS
KW - FILARIASIS
KW - PARASITES
KW - HELMINTHIASIS
KW - diethylcarbamazine
KW - filariasis
KW - phosphocholine antibodies
N1 - Accession Number: 16173974; Lal, R. B. 1 Ottesen, E. A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA.; Source Info: Jan1989, Vol. 75 Issue 1, p52; Subject Term: IMMUNOGLOBULINS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: ANTIGENS; Subject Term: FILARIASIS; Subject Term: PARASITES; Subject Term: HELMINTHIASIS; Author-Supplied Keyword: diethylcarbamazine; Author-Supplied Keyword: filariasis; Author-Supplied Keyword: phosphocholine antibodies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chopra, R.K.
AU - Powers, D.C.
AU - Adler, W.H.
AU - Nagel, J.E.
T1 - Phorbol myristate acetate and calcium ionophore A23187-stimulated human T cells do not express high-affinity IL-2 receptors.
JO - Immunology
JF - Immunology
Y1 - 1989/01//
VL - 66
IS - 1
M3 - Article
SP - 54
EP - 60
PB - Wiley-Blackwell
SN - 00192805
AB - Phorbol myristate acetage (PMA) and Ca2+ ionophore A23187 mimic early signal transduction pathways and activate purified human T cells to secrete large quantities of interleukin-2 (IL-2) and to proliferate. Despite producing 50-100-fold more IL-2 than phytohaemagglutinin (PHA)-activated peripheral blood lymphocytes (PBL), PMA/A23187-stimulated human T cells proliferate less than cells activated by PHA. Washing the cells to remove PMA/A23187 was found to increase cellular proliferation two to five-fold. High-affinity IL-2R (HA-IL-2R) were found to be expressed by human T cells that had been washed 24 hr after PMA/A23187 stimulation and recultured without stimulus for an additional 48 hr, but not by T cells constantly exposed to PMA/A23187 for 72 hr. Radioligand binding studies with [125I]IL-2 demonstrated that while the α (p55) and Β (p70-75) subunits of HA-IL2R were both present on the constant PMA/A23187-stimulated T cells, they did not appear to associate to form functional HA-IL-2R. This defect in the expression of bio-active HA-IL-2R on constant PMA/A23187-stimulated human T cells seems to account for their low proliferative response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHORBOLS
KW - T cells
KW - INTERLEUKIN-2
KW - CELL proliferation
KW - LYMPHOCYTES
KW - PHYTOHEMAGGLUTININS
N1 - Accession Number: 13363142; Chopra, R.K. 1 Powers, D.C. 1 Adler, W.H. 1 Nagel, J.E. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, U.S.A.; Source Info: Jan1989, Vol. 66 Issue 1, p54; Subject Term: PHORBOLS; Subject Term: T cells; Subject Term: INTERLEUKIN-2; Subject Term: CELL proliferation; Subject Term: LYMPHOCYTES; Subject Term: PHYTOHEMAGGLUTININS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mueller, Stephan
AU - Klaus-Kovtun, Vera
AU - Stanley, John R.
T1 - A 230-kD Basic Protein Is the Major Bullous Pemphigoid Antigen.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/01//
VL - 92
IS - 1
M3 - Article
SP - 33
EP - 38
SN - 0022202X
AB - Recent studies have demonstrated that bullous pemphigoid (BP) antigen, in extracts of cultured human keratinocytes and normal human epidermis, is a 230-kD polypeptide. However, other recent studies have suggested that there is heterogeneity of EP antigen at the molecular level. To demonstrate that this 230-kD polypeptide is the major BP antigen and to further characterize it, we tested multiple BP sera by both immunoprecipitation of extracts of radiolabeled cultured human keratinocytes and immunoblotting of extracts of normal human epidermis. Thirty-six of 37 BP sera immunoprecipitated the 230-kD polypeptide, and 11 of 13 BP sera identified the 230-kD polypeptide by immunoblotting. Eighty-six disease and normal control sera did not hind the 230-kD BP antigen. Immunoprecipitation was a more sensitive assay than was immunoblotting to detect the 230-kD antigen; BP sera that were weak or negative by immunoblotting were strongly positive by immunoprecipitation. To demonstrate that this 230-kD polypeptide shared epitopes, defined by BP sera, with the epidermal basement membrane zone, we showed that BP IgG affinity purified on this polypeptide bound the epidermal basement membrane zone by immunofluorescence. To further characterize the BP antigen and to compare the antigen synthesized by cultured human keratinocytes to the antigen extracted from epidermis, we analyzed the 230-kD BP antigen by two-dimensional gel electrophoresis. BP antigen immunoprecipitated from culture extracts or HP antigen identified by immunoblots of epidermal extracts was a single spot on two-dimensional gels, with a pI of about 8. These data indicate that, although other polypeptides are sometimes identified (e.g., a 166 kD band by immunoprecipitation or a 180 kD band on immunoblots), the major BP antigen identified in cultured human keratinocytes is similar to the antigen found in normal human epidermis and is a basic 230-kD polypeptide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - ANTIGENS
KW - KERATINOCYTES
KW - EPIDERMIS
KW - PEPTIDE hormones
KW - IMMUNOGLOBULINS
KW - IMMUNOBLOTTING
N1 - Accession Number: 13070476; Mueller, Stephan 1 Klaus-Kovtun, Vera 1 Stanley, John R. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, U.S.A.; Source Info: Jan1989, Vol. 92 Issue 1, p33; Subject Term: PROTEINS; Subject Term: ANTIGENS; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: PEPTIDE hormones; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOBLOTTING; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep13070476
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13070476&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Tingley, D E
AU - Oates, G K
AU - Siegel, E R
T1 - Managing clinical information: what services physicians use, want, and need
JO - Proceedings of the 52nd Annual Meeting of the American Society for Information Science
JF - Proceedings of the 52nd Annual Meeting of the American Society for Information Science
Y1 - 1989///
M3 - Conference Paper
SP - 240
EP - 240
AB - These discussions address problems health professionals face regarding the expanding medical knowledge base. Specific issues covered are: how physicians value and use information resources; and an assessment of the impact of the MEDLINE database based on several hundred interviews with end-users. Proceeding Published by Learned Information, United States, 1989
KW - LIBRARY users
KW - INFORMATION services
KW - Healthcare
KW - Information management
N1 - Accession Number: ISTA2601372; Tingley, D E 1; Oates, G K; Siegel, E R; Affiliations: 1 : National Cancer Institute, Bethesda, MD; Source Info: 1989, p240; Note: Place of Publication: United States; Note: Publisher: Learned Information; Note: Update Code: 2600; Note: Conference Title: Proceedings of the 52nd Annual Meeting of the American Society for Information Science; Note: Conference Location: Washington, DC; Note: Conference Dates: November 1989; Subject Term: LIBRARY users; Subject Term: INFORMATION services; Author-Supplied Keyword: Healthcare; Author-Supplied Keyword: Information management; Number of Pages: 1p; Document Type: Conference Paper
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 2014-03175-001
AN - 2014-03175-001
AU - Brown, Neal B.
T1 - Guest editorial.
T3 - The Community Support System Concept
JF - Psychosocial Rehabilitation Journal
JO - Psychosocial Rehabilitation Journal
Y1 - 1989/01//
VL - 12
IS - 3
SP - 1
EP - 3
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN - 0147-5622
N1 - Accession Number: 2014-03175-001. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Brown, Neal B.; National Institute of Mental Health, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Community Services; Mental Disorders; Mental Health Programs; Social Support. Minor Descriptor: Deinstitutionalization; Mental Health. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 3. Issue Publication Date: Jan, 1989.
AB - This editorial introduces the community support programs (CSP) for mentally disabled people initiated by National Institute of Mental Health (NIMH) in the year 1974. This program seeks to address the problems resulting from deinstitutionalization and the need for improved community-based services and supports for the mentally disabled. The present issue provide the reader with several views of a CSS, the concept which serves as the basis for all NIMH CSP efforts. The Community Support Program has been successful in a number of ways. The Program has generated a strong network of individuals committed to community support principles. There is good reason to be optimistic about the future of mental health and community support services for persons with long-term mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community support programs
KW - mentally ill persons
KW - deinstitutionalization
KW - mental health
KW - 1989
KW - Community Services
KW - Mental Disorders
KW - Mental Health Programs
KW - Social Support
KW - Deinstitutionalization
KW - Mental Health
KW - 1989
DO - 10.1037/h0099538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-03175-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09768-001
AN - 2005-09768-001
AU - Judd, Lewis L.
T1 - Foreword.
T3 - Report of the U.S. Delegation Soviet Response
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 4, Suppl
SP - i
EP - ii
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
N1 - Accession Number: 2005-09768-001. Partial author list: First Author & Affiliation: Judd, Lewis L.; National Institute of Mental Health, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Forensic Evaluation; Human Rights; International Relations; Psychiatrists; Psychiatry. Minor Descriptor: Cross Cultural Differences. Classification: Health & Mental Health Treatment & Prevention (3300); Civil Rights & Civil Law (4210). Population: Human (10). Location: USSR; US. Page Count: 2. Issue Publication Date: 1989.
AB - The report being discussed here, co-edited by professionals from the U.S. and U.S.S.R., is unique in the history of the National Institute of Mental Health (NIMH) and the 'Schizophrenia Bulletin.' It contains an unusual and historically important dialogue between psychiatric and forensic experts in the United States and the Soviet Union concerning the results of a visit by a Department of State-led Delegation formed to assess recent changes in Soviet psychiatry, particularly those affecting human rights and the forensic system. It documents, as well, the key role of NIMH in providing the scientific expertise and technical support essential to assure the international credibility of the Delegation's findings. In the late 1970s, Soviet allegations of human rights abuses in psychiatry led to a suspension of scientific exchange between the U.S. and the U.S.S.R. in the area of brain sciences and mental illness. Clearly, a strengthening of human rights protections in psychiatry and many other aspects of Soviet life, is a prerequisite to the resumption of such exchange. As an outgrowth of the largely positive Soviet response to the Delegation's visit and its report, a limited professional visit related to psychiatric and forensic practice is underway. The Department of State is sponsoring this visit in early 1990 to expose Soviet psychiatrists and forensic experts to current U.S. approaches to psychiatric diagnosis and treatment, service delivery, and forensic psychiatric practices. This journal has identical articles written in Russian and English. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - forensic experts
KW - professional visits
KW - service delivery
KW - human right abuses
KW - Soviet psychiatry
KW - American Delegation
KW - scientific expertise
KW - technical support
KW - 1989
KW - Forensic Evaluation
KW - Human Rights
KW - International Relations
KW - Psychiatrists
KW - Psychiatry
KW - Cross Cultural Differences
KW - 1989
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09768-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06494-016
AN - 2006-06494-016
AU - Friedman, Sarah L.
T1 - The Development of Social Cognition: Novel, Familiar, and Missing Snapshots.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1989/01//
VL - 34
IS - 1
SP - 25
EP - 28
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06494-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Friedman, Sarah L.; National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Child Psychology; Childhood Development; Social Behavior; Social Cognition. Classification: Developmental Psychology (2800). Population: Human (10). Reviewed Item: Perlmutter, Marion (Ed). Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18=Hillsdale, NJ: Erlbaum, 1986. 344 pp. $34.95; 1986. References Available: Y. Page Count: 4. Issue Publication Date: Jan, 1989.
AB - Reviews the book, Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18 by Marion Perlmutter (Ed.) (1986). This volume provides snapshots of topics, concepts, research methods, and findings directly or indirectly related to the study of the development of social cognition. This volume focuses on cognitive perspectives that may usefully inform the study of social behavior and development. These perspectives are both theoretical and methodological. The cognitive perspectives that Fischer and Elmendorf bring to the study of social cognition are both methodological and explanatory. Finally, the volume features a cognitive perspective about children's understanding of control, the capacity to cause intended events. In summary, the volume is rich in interesting ideas and findings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral development
KW - social development
KW - child psychology
KW - social cognition
KW - 1989
KW - Child Psychology
KW - Childhood Development
KW - Social Behavior
KW - Social Cognition
KW - 1989
U2 - Perlmutter, Marion (Ed). (1986); Cognitive Perspectives on Children's Social and Behavioral Development: The Minnesota Symposium on Child Psychology, Vol. 18; Hillsdale, NJ: Erlbaum, 1986. 344 pp. $34.95; 0-89859-546-0.
DO - 10.1037/027528
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06494-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09722-005
AN - 2005-09722-005
AU - Rosenstein, Marilyn J.
AU - Milazzo-Sayre, Laura J.
AU - Manderscheid, Ronald W.
T1 - Care of Persons With 45 Schizophrenia: A Statistical Profile.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 1
SP - 45
EP - 58
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Manderscheid, Ronald W., Survey and Reports Branch, DBAS, NIMH, Rm. 18C-07, Parklawn Bldg., 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09722-005. PMID: 2717889 Partial author list: First Author & Affiliation: Rosenstein, Marilyn J.; Survey and Reports Branch, Division of Biometry and Applied Sciences, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Mental Health; Mental Health Programs; Mental Health Services; Schizophrenia. Minor Descriptor: Outpatients. Classification: Schizophrenia & Psychotic States (3213); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 1989.
AB - This article presents the latest information available from the National Reporting Program for Mental Health Statistics on the distribution and characteristics of persons with schizophrenia served by organized, specialty inpatient, outpatient, and partial care mental health programs. Results are presented separately for persons under care at one point in time and for persons admitted over a 1-year period, in order to examine the potential for change in each type of care. Findings show that about 900,000 persons with schizophrenia were served in 1986; that inpatient and outpatient programs were relatively equivalent in total numbers served, but that considerably more patient turnover occurred in inpatient programs; and that partial care programs, although small, were evolving as a locus of care for persons with schizophrenia. Some variations were observed among the different types of organizations offering each type of care, and characteristics of clients/patients that could lead to changes in each type of care were evident. Overall, the findings present a useful composite picture of specialty mental health care for persons with schizophrenia. The need for longitudinal, prospective research is noted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - mental health care
KW - mental health programs
KW - 1989
KW - Health Care Services
KW - Mental Health
KW - Mental Health Programs
KW - Mental Health Services
KW - Schizophrenia
KW - Outpatients
KW - 1989
DO - 10.1093/schbul/15.1.45
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09722-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09722-014
AN - 2005-09722-014
AU - Lyon, Melvin
AU - Barr, Chris E.
AU - Cannon, Tyrone D.
AU - Mednick, Sarnoff A.
AU - Shore, David
T1 - Fetal Neural Development and Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 1
SP - 149
EP - 160
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Lyon, Melvin, Social Science Research Institute, USC, Los Angeles, CA, US, 90089-1111
N1 - Accession Number: 2005-09722-014. Partial author list: First Author & Affiliation: Lyon, Melvin; Social Science Research Institute, University of Southern California, Los Angeles, CA, US. Other Publishers: Oxford University Press. Release Date: 20050919. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amygdala; Basal Ganglia; Hippocampus; Neural Development; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: 1989.
AB - The conference on Fetal Neural Development and Schizophrenia which was held in Washington, DC, May 31-June 1, 1988, focused on factors of possible etiological significance in fetal development. Schizophrenia researchers joined experts in brain imaging, neuropathological, and neurochemical changes in brain development and investigators of potential genetic and neurobehavioral causes of psychosis. The combined evidence suggested dysfunction in frontal and parieto-occipital neocortex, basal ganglia, hippocampus, and amygdala. Dopamine transmission was implicated both in basal ganglia deficits and in widespread neocortical disturbances. Viral infection, or excessive stress, during the second trimester of pregnancy, as well as obstetrical complications, minor physical anomalies, and brain defects, correlated positively with incidence of adult schizophrenia. Autonomic nonresponding, birth complications, and ventricular enlargement were found to be closely related to negative symptom schizophrenia in high-risk populations. A dual factor model of schizophrenia was suggested, where genetic and environmental influences combine to produce psychosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal neural development
KW - schizophrenia
KW - basal ganglia
KW - amygdala
KW - hippocampus
KW - 1989
KW - Amygdala
KW - Basal Ganglia
KW - Hippocampus
KW - Neural Development
KW - Schizophrenia
KW - 1989
DO - 10.1093/schbul/15.1.149
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09722-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09776-003
AN - 2005-09776-003
AU - Schulz, S. Charles
AU - Pato, Carlos N.
T1 - Advances in the Genetics of Schizophrenia: Editors' Introduction.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 3
SP - 361
EP - 363
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Pato, Carlos N., Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09776-003. PMID: 2573148 Partial author list: First Author & Affiliation: Schulz, S. Charles; Schizophrenia Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060227. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Genetics; Schizophrenia. Minor Descriptor: Genetic Linkage. Classification: Research Methods & Experimental Design (2260); Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1989.
AB - In view of the rapid advances in the application of molecular genetics to research in schizophrenia, an effort was made to put these studies into a wider perspective. This issue of the Schizophrenia Bulletin is devoted to the expanded presentation of some of the early genetic linkage findings in schizophrenia, and a broader discussion of the impact of these new techniques on schizophrenia research, as well as the limitations of this approach in a complex disorder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - molecular genetics
KW - schizophrenia research
KW - genetic advancement
KW - schizophrenia
KW - genetic linkage
KW - 1989
KW - Experimentation
KW - Genetics
KW - Schizophrenia
KW - Genetic Linkage
KW - 1989
DO - 10.1093/schbul/15.3.361
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09776-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09776-004
AN - 2005-09776-004
AU - Pato, Carlos N.
AU - Lander, Eric S.
AU - Schulz, S. Charles
T1 - Prospects for the Genetic Analysis of Schizophrenia.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 3
SP - 365
EP - 372
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Pato, Carlos N., Genetics Research Program, Schizophrenia Research Branch, NIMH, Rm. 10C-06, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09776-004. PMID: 2683037 Partial author list: First Author & Affiliation: Pato, Carlos N.; Genetics Research Program, Schizophrenia Research Branch, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20060227. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Genetic Linkage; Genetics; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: 1989.
AB - This issue of the Schizophrenia Bulletin provides a forum for the presentation of early results and speculative hypotheses based on the application of molecular genetic methods for linkage studies in schizophrenia. Contributors were given the freedom to explore the historical and theoretical perspectives on the genetics of schizophrenia. They were also asked to balance their enthusiasm and cautious skepticism at the new suggestions of linkage involving chromosome 5 (Sherrington et al. 1988). In this overview, the epidemiologic evidence for a genetic factor in schizophrenia and recent linkage studies are briefly discussed. In addition, the potential and limitations of different linkage strategies in schizophrenia are examined. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genetic linkage analysis
KW - molecular genetic methods
KW - theoretical perspectives
KW - historical perspectives
KW - epidemiologic evidence
KW - 1989
KW - Epidemiology
KW - Genetic Linkage
KW - Genetics
KW - Schizophrenia
KW - 1989
DO - 10.1093/schbul/15.3.365
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09776-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09760-002
AN - 2005-09760-002
AU - Keith, Samuel J.
AU - Regier, Darrel A.
T1 - U.S. and Soviet perspectives on the diagnosis of schizophrenia and associated dangerousness.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 4
SP - 515
EP - 517
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Keith, Samuel J., Division of Clinical Research, National Institute of Mental Health, Parklawn Bldg., Rm. 10-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09760-002. PMID: 2623436 Partial author list: First Author & Affiliation: Keith, Samuel J.; Division of Clinical Research, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Dangerousness; Diagnosis; Mental Disorders; Schizophrenia. Minor Descriptor: Psychiatric Patients; Role Taking. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: Russia; US. References Available: Y. Page Count: 3. Issue Publication Date: 1989.
AB - During a visit of U.S. senior mental health and forensic experts to the Soviet Union to assess recent changes in Soviet psychiatry, a symposium was held to discuss the U.S. and Soviet concepts of the diagnosis of schizophrenia and dangerousness associated with psychiatric illness. The basic conclusion from this exchange was that significant differences exist between the countries in both areas, as the U.S. conceptualization of schizophrenia and associated dangerousness is considerably narrower than that of Soviet practice. Clearly, future scientific exchange is warranted to examine these conceptual differences in an effort to establish a better empirical basis for assessing the most appropriate medical treatment and legal disposition for patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - US perspective
KW - Soviet perspective
KW - schizophrenia diagnosis
KW - psychiatric illness dangerousness
KW - 1989
KW - Cross Cultural Differences
KW - Dangerousness
KW - Diagnosis
KW - Mental Disorders
KW - Schizophrenia
KW - Psychiatric Patients
KW - Role Taking
KW - 1989
DO - 10.1093/schbul/15.4.515
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09760-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09760-005
AN - 2005-09760-005
AU - Monahan, John
AU - Shah, Saleem A.
T1 - Dangerousness and Commitment of the Mentally Disordered in the United States.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1989///
VL - 15
IS - 4
SP - 541
EP - 553
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Monahan, John, NIMH, Parklawn Bldg., Room 18-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09760-005. PMID: 2696085 Partial author list: First Author & Affiliation: Monahan, John; University of Virginia, Charlottesville, VA, US. Other Publishers: Oxford University Press. Release Date: 20051003. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Commitment (Psychiatric); Laws; Mental Disorders; Mentally Ill Offenders. Minor Descriptor: Dangerousness. Classification: Psychological Disorders (3210); Forensic Psychology & Legal Issues (4200). Population: Human (10). Location: US. Tests & Measures: National Institute of Mental Health Survey. Methodology: Empirical Study. References Available: Y. Page Count: 13. Issue Publication Date: 1989.
AB - This article describes recent developments in mental health laws in the United States, especially as they relate to uses of the concept of 'dangerousness' in the civil and criminal commitment of the mentally ill. In addition to providing a brief overview of the U.S. legal system and noting the importance of the Rule of Law, we review the historical development and current status of the relevant laws, provide some basic epidemiological statistics, and refer to some of the considerable body of extant empirical research in the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mentally disordered
KW - mental health laws
KW - criminal commitment
KW - dangerousness
KW - civil commitment
KW - US legal system
KW - epidemiology
KW - 1989
KW - Commitment (Psychiatric)
KW - Laws
KW - Mental Disorders
KW - Mentally Ill Offenders
KW - Dangerousness
KW - 1989
DO - 10.1093/schbul/15.4.541
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09760-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09117-001
AN - 2008-09117-001
AU - Kelty, Miriam F.
AU - Hastings, Margaret M.
AU - Cahn, Jerry
AU - Kaplan, Robert M.
AU - Curbow, Barbara
AU - Bransfield, Diana D.
AU - Gallant, Sheryle J. A.
AU - DeLeon, Patrick
AU - Bryant, Patricia
AU - Wickram, Ian
AU - Millstein, Susan G.
T1 - Health policy.
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1989///
VL - 8
IS - 6
SP - 773
EP - 775
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
AD - Kelty, Miriam F., National Institute on Aging, National Institutes of Health, Room 5C-06, Building 31, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-09117-001. PMID: 2637865 Partial author list: First Author & Affiliation: Kelty, Miriam F.; National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Health; Health Care Policy. Minor Descriptor: Behavioral Sciences; Government Policy Making; Legislative Processes; Private Sector; Professional Organizations. Classification: Promotion & Maintenance of Health & Wellness (3365); Political Processes & Political Issues (2960). Population: Human (10). Page Count: 3. Issue Publication Date: 1989. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1989.
AB - The charge to the task force on health policy was to consider policy relevant to health and behavior. Legislative initiatives, private sector initiatives, and the interface among professional societies were addressed. More specifically, the task force discussed ways in which research must be conducted and presented to maximize its usefulness to policy makers, areas of interface between the behavioral sciences and health policy, and methods of training scientists to be more effective in shaping policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health policy
KW - health
KW - behavior
KW - legislative initiatives
KW - private sector initiatives
KW - professional societies
KW - behavioral sciences
KW - 1989
KW - Behavior
KW - Health
KW - Health Care Policy
KW - Behavioral Sciences
KW - Government Policy Making
KW - Legislative Processes
KW - Private Sector
KW - Professional Organizations
KW - 1989
DO - 10.1037/h0090322
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09117-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09118-001
AN - 2008-09118-001
AU - Drotar, Dennis
AU - Johnson, Suzanne Bennett
AU - Iannotti, Ron
AU - Krasnegor, Norman
AU - Matthews, Karen A.
AU - Melamed, Barbara G.
AU - Millstein, Sharon
AU - Peterson, Rolf A.
AU - Popiel, Debbie
AU - Routh, Donald K.
T1 - Child health psychology.
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1989///
VL - 8
IS - 6
SP - 781
EP - 784
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
AD - Drotar, Dennis, Department of Psychiatry, Metro Health Medical Center, 3395 Scranton Road, Cleveland, OH, US, 44109
N1 - Accession Number: 2008-09118-001. PMID: 2637867 Partial author list: First Author & Affiliation: Drotar, Dennis; Case Western Reserve University School of Medicine, Cleveland, OH, US. Other Publishers: American Psychological Association. Release Date: 20080714. Correction Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Psychology; Childhood Development; Developmental Psychology; Experimentation; Health Care Psychology. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 4. Issue Publication Date: 1989. Copyright Statement: Lawrence Erlbaum Associates, Inc. 1989.
AB - [Correction Notice: An erratum for this article was reported in Vol 9(6) of Health Psychology (see record [rid]2008-09119-001[/rid]). The name of the author, Sharon Millstein, should be Susan Millstein.] The term child health psychology refers to the field of research on the behavioral aspects of children's health and illness. At this time we need to continue the work of the child health psychology special interest group and to draw into the Division of Health Psychology a much larger number of developmental psychologists, who need to be informed about the relevance of their scientific training to child health issues. We call the Division's attention and that of granting agencies such as the National Institute of Child Health and Human Development to the following high-priority child health research issues: adherence to pediatric medical regimens; child health promotion; family influences on child and adolescent health and disease; and stress and coping in childhood illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child health psychology
KW - developmental psychology
KW - child health research
KW - 1989
KW - Child Psychology
KW - Childhood Development
KW - Developmental Psychology
KW - Experimentation
KW - Health Care Psychology
KW - 1989
DO - 10.1037/h0090323
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09118-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2016-09459-001
AN - 2016-09459-001
AU - Brott, Thomas
AU - Adams, Harold P. Jr.
AU - Olinger, Charles P.
AU - Marle, John R.
AU - Barsan, William G.
AU - Biller, José
AU - Spilker, Judith
AU - Holleran, Renée
AU - Eberle, Robert
AU - Hertzberg, Vicki
AU - Rorick, Marvin
AU - Moomaw, Charles J.
AU - Walker, Michael
T1 - Measurements of acute cerebral infarction: A clinical examination scale.
JF - Stroke
JO - Stroke
JA - Stroke
Y1 - 1989/01//
VL - 20
IS - 7
SP - 864
EP - 870
CY - US
PB - American Heart Association
SN - 0039-2499
SN - 1524-4628
AD - Brott, Thomas, Department of Neurology, University of Cincinnati Medical Center, 231 Bethesda Avenue, Cincinnati, OH, US, 45267-0525
N1 - Accession Number: 2016-09459-001. PMID: 2749846 Partial author list: First Author & Affiliation: Brott, Thomas; Department of Neurology, University of Cincinnati, Cincinnati, OH, US. Release Date: 20160229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Hemorrhage; Psychometrics; Test Reliability. Minor Descriptor: Achievement Measures. Classification: Clinical Psychological Testing (2224); Neurological Disorders & Brain Damage (3297). Population: Human (10). Tests & Measures: Toronto Stroke Scale; Oxbury Initial Severity Scale; Cincinnati Stroke Scale; Edinburgh-2 Coma Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1989. Publication History: Accepted Date: Jan 9, 1989; First Submitted Date: Nov 7, 1988.
AB - We designed a 15-item neurologic examination stroke scale for use in acute stroke therapy trials. In a study of 24 stroke patients, interrater reliability for the scale was found to be high (mean κ = 0.69), and test-retest reliability was also high (mean κ = 0.66-0.77). Test-retest reliability did not differ significantly among a neurologist, a neurology house officer, a neurology nurse, or an emergency department nurse. The stroke scale validity was assessed by comparing the scale scores obtained prospectively on 65 acute stroke patients to the patients' infarction size as measured by computed tomography scan at 1 week and to the patients' clinical outcome as determined at 3 months. These correlations (scale-lesion size r = 0.68, scale-outcome r = 0.79) suggested acceptable examination and scale validity. Of the 15 test items, the most interrater reliable item (pupillary response) had low validity. Less reliable items such as upper or lower extremity motor function were more valid. We discuss methods for improving the reliability and validity of brief examination scales to be used in stroke therapy trials. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - acute cerebral infarction
KW - test reliability
KW - psychometrics
KW - clinical examination scale
KW - 1989
KW - Cerebral Hemorrhage
KW - Psychometrics
KW - Test Reliability
KW - Achievement Measures
KW - 1989
U1 - Sponsor: United States Public Health Service, National Institutes of Health, National Institute of Neurological Disorders and Stroke, US. Grant: N01-NS-2324; N01-NS-2326. Other Details: TO 1 (University of Cincinnati), TO 1 (University of Iowa). Recipients: No recipient indicated
DO - 10.1161/01.STR.20.7.864
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2016-09459-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cone, Edward J.
AU - Henningfield, Jack E.
AU - Cone, E J
AU - Henningfield, J E
T1 - Premier 'smokeless cigarettes' can be used to deliver crack.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/06/
VL - 261
IS - 1
M3 - letter
SP - 41
EP - 41
SN - 00987484
AB - Presents a letter to the editor of the January 6, 1989 issue of the 'Journal of the American Medical Association,' regarding the commercial introduction into the U.S. market of the Premier smokeless cigarette of R.J. Reynolds Tobacco Co.
KW - SMOKELESS tobacco
KW - LETTERS to the editor
KW - COCAINE
KW - SMOKING
KW - SUBSTANCE abuse
KW - PRODUCT design
KW - UNITED States
KW - R.J. Reynolds Tobacco Co.
N1 - Accession Number: 10949514; Cone, Edward J. 1 Henningfield, Jack E. 1 Cone, E J Henningfield, J E; Affiliation: 1: National Institute on Drug Abuse, Baltimore; Source Info: 1/6/89, Vol. 261 Issue 1, p41; Subject Term: SMOKELESS tobacco; Subject Term: LETTERS to the editor; Subject Term: COCAINE; Subject Term: SMOKING; Subject Term: SUBSTANCE abuse; Subject Term: PRODUCT design; Subject Term: UNITED States; Company/Entity: R.J. Reynolds Tobacco Co.; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 1p; Document Type: letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - From the National Institutes of Health.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/13/
VL - 261
IS - 2
M3 - Article
SP - 200
EP - 200
SN - 00987484
AB - Provides information provided by the U.S. National Institutes of Health on issues affecting the health of black Americans, as of January 1989. Prevalence of diabetes in black Americans; Evidence showing that black Americans have the higher age-adjusted incidence and mortality rates for several cancers; Incidence of low birth weight in urban black populations.
KW - AFRICAN Americans -- Health
KW - PUBLIC health
KW - DIABETES
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 10949566; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 1/13/89, Vol. 261 Issue 2, p200; Subject Term: AFRICAN Americans -- Health; Subject Term: PUBLIC health; Subject Term: DIABETES; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Staddon, James M.
AU - Hansford, Richard G.
T1 - Evidence indicating that the glucagon-induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/01/15/
VL - 179
IS - 1
M3 - Article
SP - 47
EP - 52
PB - Wiley-Blackwell
SN - 00142956
AB - The mechanism whereby glucagon causes an increase in the concentration of cytoplasmic free Ca2+, [Ca2+]c, in isolated hepatocytes has been investigated. There have been proposals of cyclic-AMP-dependent and cyclicAMP-independent mechanisms. In this work, the inactivation of pyruvate kinase was used as an indicator of increases in the activity of cyclic-AMP-dependent protein kinase, A-kinase. [Ca2+]c was measured using the fluorescent probe indo-1. The decrease in activity of pyruvate kinase caused by an increase in [Ca2+]c alone, i.e. mediated by mechanisms not involving cyclic AMP and exemplified by the effect of vasopressin, was of minimal significance under the conditions of the enzyme assay. Studies of the effects of a wide range of glucagon concentrations indicate that any increase in [Ca2+]c caused by glucagon was always associated with a decrease in pyruvate kinase activity. A similar relationship was obtained if glucagon-receptor occupancy was circumvented by using the 8-bromo-derivative of cyclic AMP to activate the A-kinase. It was also found that the cyclic AMP phosphodiesterase inhibitor isobutylmethylxanthine could potentiate the ability of glucagon to increase ICa2+]c: no such potentiation was observed when vasopressin was used to raise [Ca2+]c. Together these data indicate that an increase in cyclic AMP concentration, sufficiently great to activate A-kinase, is a mechanism that mediates the glucagon-induced increase in [Ca2+]c. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCAGON
KW - PANCREATIC secretions
KW - PEPTIDE hormones
KW - ADENYLIC acid
KW - BIOCHEMISTRY
KW - MOLECULAR biology
N1 - Accession Number: 13746880; Staddon, James M. 1 Hansford, Richard G. 1; Affiliation: 1: National Institutes of Health, Gerontology Research Center, Baltimore, Maryland; Source Info: 1/15/89, Vol. 179 Issue 1, p47; Subject Term: GLUCAGON; Subject Term: PANCREATIC secretions; Subject Term: PEPTIDE hormones; Subject Term: ADENYLIC acid; Subject Term: BIOCHEMISTRY; Subject Term: MOLECULAR biology; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sandler, Dale P.
AU - Comstock, George W.
AU - Helsing, Knud J.
AU - Shore, David L.
T1 - Deaths from All Causes in Non-Smokers Who Lived with Smokers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/02//
VL - 79
IS - 2
M3 - Article
SP - 163
EP - 167
PB - American Public Health Association
SN - 00900036
AB - Mortality associated with passive smoking was evaluated in a 12-year study of 27,891 White adult smokers and 19,035 never smokers identified in 1963. Death rates were calculated using an estimate of the person-years at risk. Adjusted for age, marital status, education, and quality of housing, the estimated relative risks of death from all causes were 1.17 (approximate 95% confidence interval 1.01, 1.36) for men and 1.15 (1.06, 1.24) for women with passive exposure. These relative risks were similar to those for ex-smokers and for pipe or cigar smokers. Risks increased slightly with level of exposure. The relative risk from passive smoking was greatest for men under age 50 (RR = 2.09, 1.31-3.34). Risks from passive smoking were slightly elevated for several causes among men and women, and may be broader than those previously reported. On the other hand, these small nonspecific increases in death rates may reflect other characteristics of passive smokers that increase mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PASSIVE smoking
KW - RESEARCH
KW - SMOKING
KW - MORTALITY
KW - MORTALITY -- Statistics
KW - CIGARETTE smokers
KW - MORTALITY -- Tables
KW - STATISTICAL hypothesis testing
N1 - Accession Number: 4682714; Sandler, Dale P. 1 Comstock, George W. 2 Helsing, Knud J. 2 Shore, David L. 1; Affiliation: 1: Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences 2: Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health; Source Info: Feb1989, Vol. 79 Issue 2, p163; Subject Term: PASSIVE smoking; Subject Term: RESEARCH; Subject Term: SMOKING; Subject Term: MORTALITY; Subject Term: MORTALITY -- Statistics; Subject Term: CIGARETTE smokers; Subject Term: MORTALITY -- Tables; Subject Term: STATISTICAL hypothesis testing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagel, J. E.
AU - Chopra, R. K.
AU - Powers, D. C.
AU - Adler, W. H.
T1 - Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/02//
VL - 75
IS - 2
M3 - Article
SP - 286
EP - 291
PB - Wiley-Blackwell
SN - 00099104
AB - High affinity interleukin 2 receptors (HA-IL-2R) on mitogen-or antigen-stimulated T cells have been shown to efficiently bind interleukin 2 (IL-2) and to transduce the activation signal(s) that facilitate proliferation. This study was initiated to determine whether the impaired proliferative response of T cells from elderly individuals can be attributed to the defective expression of HA-IL-2R. While cells from both young and old individuals had statistically insignificant differences in the number of HA-IL-2R per membrane IL-2R-positive cell and these receptors displayed similar binding affinities with 125-IL-2, there were consistently fewer cells and fewer cells expressing HA-IL-2R in the cell cultures from elderly individuals. The magnitude of the age-associated impairment in cell proliferation was decreased, but remained present, when Percoll fractionated lymphoblasts, as compared to peripheral blood lymphocytes (PBL), were cultured in the presence of exogenous interleukin 2 (IL-2). The results demonstrate that a significantly larger percentage of lymphocytes from elderly individuals do not respond to mitogenic stimulation and, probably due to stimulus stress, die in culture. As a consequence there are fewer functionally competent cells expressing the HA-IL-2R in cultures from elderly individuals, which in turn contributes to the age-related defect in the lymphocyte proliferative response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-2
KW - ANTIGENS
KW - T cells
KW - CELL culture
KW - LYMPHOCYTES
KW - CELL proliferation
KW - aging
KW - interleukin 2
KW - interleukin 2 receptor
N1 - Accession Number: 16159086; Nagel, J. E. 1 Chopra, R. K. 1 Powers, D. C. 1 Adler, W. H. 1; Affiliation: 1: Clinical Immunology Section, Gerontology Research Center, National Institute On Aging, National Institutes of Health, Baltimore, MD 21224.; Source Info: Feb1989, Vol. 75 Issue 2, p286; Subject Term: INTERLEUKIN-2; Subject Term: ANTIGENS; Subject Term: T cells; Subject Term: CELL culture; Subject Term: LYMPHOCYTES; Subject Term: CELL proliferation; Author-Supplied Keyword: aging; Author-Supplied Keyword: interleukin 2; Author-Supplied Keyword: interleukin 2 receptor; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yancey, Kim B.
AU - Lawley, Thomas J.
AU - Dersookian, Mirra
AU - Harvath, Liana
T1 - Analysis of the Interaction of Human C5a and C5a des Arg with Human Monocytes and Neutrophils: Flow Cytometric and Chemotaxis Studies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/02//
VL - 92
IS - 2
M3 - Article
SP - 184
EP - 189
SN - 0022202X
AB - C5a and C5a des Arg are potent complement-derived mediators that bind receptors on peripheral blood leukocytes and tissue-specific cellular elements to elicit and amplify inflammatory and immunomodulatory reactions. To study the interactions of C5a and C5a des Arg with these cells, fluorescein conjugates of these ligands were prepared by a new technique and their binding to monocytes, neutrophils, platelets, and endothelial cells was studied with flow cytometry. Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities. Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes. Ligand binding was specifically inhibited by native purified human C5a in a concentration-dependent manner, while it was unaffected by C3a or N-formyl-methionyl- leucylphenylalanine-lysine. There was no evidence of a C5a receptor-negative subpopulation of monocytes or neutrophils. Moreover, comparative binding experiments with leukocytes from multiple normal volunteers showed that a greater percentage of monocytes than neutrophils bound C5a at less than saturable concentrations of ligand (P < 0.05, 0.5 to 5.0 nM). A representative half-maximal binding of fluorescein-conjugated C5a (C5a des Arg) binding to monocytes and neutrophils was 1.2 nM (30 nM) and 2.6 nM (68 nM), respectively. In contrast, fluorescein-conjugated C5a did not specifically bind to human platelets or umbilical vein endothelial cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCYTES
KW - NEUTROPHILS
KW - CHEMOTAXIS
KW - LEUCOCYTES
KW - FLUORESCEIN
KW - CYTOMETRY
N1 - Accession Number: 12276710; Yancey, Kim B. 1 Lawley, Thomas J. 2 Dersookian, Mirra 1 Harvath, Liana 3; Affiliation: 1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. 2: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland. 3: Division of Blood and Blood Products, Office of Biologics Research and Review, Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Feb89, Vol. 92 Issue 2, p184; Subject Term: MONOCYTES; Subject Term: NEUTROPHILS; Subject Term: CHEMOTAXIS; Subject Term: LEUCOCYTES; Subject Term: FLUORESCEIN; Subject Term: CYTOMETRY; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12276710
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jetten, Anton M.
AU - George, Margaret A.
AU - Nervi, Clara
AU - Boone, Lawrence R.
AU - Rearick, James I.
T1 - Increased Cholesterol Sulfate and Cholesterol Sulfotransferase Activity in Relation to the Multi-step Process of Differentiation in Human Epidermal Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/02//
VL - 92
IS - 2
M3 - Article
SP - 203
EP - 209
SN - 0022202X
AB - In this study the synthesis of cholesterol sulfate is examined in relation to the process of squamous differentiation in normal human epidermal keratinocytes (NHEK) in culture. During the exponential growth phase, NHEK cells exhibit a relatively high colony-forming efficiency and appear undifferentiated on the basis of their morphology and expression of biochemical characteristics. At confluence, the cells undergo terminal differentiation that is characterized by the commitment to terminal cell division (reduction in colony-forming ability) and expression of the differentiated phenotype. An accumulation of cholesterol sulfate accompanies this program of differentiation. This accumulation of cholesterol sulfate parallels the increase in transglutaminase type I activity and the competence to form cross-linked envelopes, whereas it precedes the "spontaneous" formation of cross-linked envelopes. Increased cholesterol sulfotransferase activity appears to account for the increase in cholesterol sulfate. The cholesterol sulfate accumulation, as well as the increase in cholesterol sulfotransferase and transglutaminase activity, are inhibited by retinoids. However, the presence of retinoids does not prevent NHEK cells from undergoing terminal cell division at confluence. Two NHEK cell lines expressing SV40-large T antigen also undergo terminal differentiation at confluence and start to accumulate cholesterol sulfate. Two other, differentiation-defective cell lines do not exhibit an increase in cholesterol sulfate at confluence. These results show that epidermal keratinocytes in culture, like cells in the epidermis, accumulate cholesterol sulfate when undergoing squamous differentiation. This program appears to consist of a retinoid-insensitive step (commitment to terminal cell division) and a retinoid-sensitive step (expression of the squamous differentiated phenotype). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHOLESTEROL
KW - KERATINOCYTES
KW - TRANSFERASES
KW - TRANSGLUTAMINASES
KW - RETINOIDS
KW - EPIDERMIS
N1 - Accession Number: 12276731; Jetten, Anton M. 1 George, Margaret A. 1 Nervi, Clara 1 Boone, Lawrence R. 2 Rearick, James I. 3; Affiliation: 1: Cell Biology Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S..A. 2: Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, U.S..A. 3: Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri, U.S.A.; Source Info: Feb89, Vol. 92 Issue 2, p203; Subject Term: CHOLESTEROL; Subject Term: KERATINOCYTES; Subject Term: TRANSFERASES; Subject Term: TRANSGLUTAMINASES; Subject Term: RETINOIDS; Subject Term: EPIDERMIS; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12276731
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Creek, Kim E.
AU - Silverman-Jones, Carol S.
AU - de Luca, Luigi M.
T1 - Comparison of the Uptake and Metabolism of Retinol Delivered to Primary Mouse Keratinocytes Either Free or Bound to Rat Serum Retinol-binding Protein.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/02//
VL - 92
IS - 2
M3 - Article
SP - 283
EP - 289
SN - 0022202X
AB - Serum retinol-binding protein (RBP) is believed to be responsible for the transport of retinol from its storage site in the liver to vitamin A requiring target cells such as keratinocytes. We have used primary mouse keratinocytes as a model system to compare the uptake and metabolism of [3H] retinol delivered to them either free in solution or bound to RBP. RBP was purified from rat serum, loaded with [3H]retinol, and the [3H]retinol-RBP complex purified by affinity chromatography on human transthyretin-Sepharose. Keratinocytes incubated with either free [3H]retinol or [3H]retinal-RBP complex accumulated [3H]retinol in a time and temperature dependent manner, However, cells incubated with free [3H]retinol acquired 15- to 20-fold more ligand than if the retinol was delivered via RBP. The uptake of free [3H]retinol or [3H]retinol from RBP was not inhibited by excess unlabeled free retinol. The uptake of [3H]retinol from RBP was inhibited by high concentrations of holo-RBP, with half maximal inhibition occurring at 3μM holo-RBP. However, no specific binding of 125I-labeled RBP to monolayers of keratinocytes or membranes prepared from them was found indicating the absence of a high affinity RBP receptor on keratinocytes. Surprisingly, 50% of the [3H]retinol delivered to the keratinocytes during a 30-min uptake period was released from them within 30-min irrespective of whether or not it was initially delivered to them as free [3H]retinol or bound to RBP. The remaining 50% was lost at a much slower rate, but only 20% remained 24-h after delivery. Studies on retinol metabolism demonstrated that 7%12% of the total cell-associated [3H]retinol delivered during a 90-min uptake period was esterified (mostly as retinyl palmitate) whether or not it was given free in solution or bound to RBP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN A
KW - KERATINOCYTES
KW - SERUM
KW - SEPHAROSE
KW - METABOLISM
KW - TRETINOIN
N1 - Accession Number: 12276867; Creek, Kim E. 1 Silverman-Jones, Carol S. 1 de Luca, Luigi M. 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, U.S.A; Source Info: Feb89, Vol. 92 Issue 2, p283; Subject Term: VITAMIN A; Subject Term: KERATINOCYTES; Subject Term: SERUM; Subject Term: SEPHAROSE; Subject Term: METABOLISM; Subject Term: TRETINOIN; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12276867
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cain, Virginia S.
AU - Hofferth, Sandra L.
T1 - Parental Choice of Self-care for School-Age Children.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1989/02//
VL - 51
IS - 1
M3 - Article
SP - 65
EP - 77
SN - 00222445
AB - This article provides national estimates from the December 1984 Current Population Survey of the number of school-age children who, in the past four weeks, had been in self-care or in the care of a sibling or other person under the age of 14 either before school, after school, or at night. A logit model is then used to analyze, first, the use of nonparental care and, second, the choice of self-care for their children by parents who use nonparental care. The results suggest that self-care is more likely to be used by middle- and upper-income white mothers living in suburban or rural areas, with no other adults in the household, for older children, and for only a short time each day, than by other mothers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD care
KW - SCHOOL children
KW - BROTHERS & sisters
KW - MOTHERS
KW - FAMILIES
KW - Child Care and Welfare Services
KW - CHILD WELFARE, PROBLEMS, AND TREATMENT
KW - LATCHKEY CHILDREN
N1 - Accession Number: 5273866; Cain, Virginia S. 1 Hofferth, Sandra L. 2; Affiliation: 1: National Institute of Child Health and Human Development 2: Urban Institute; Source Info: Feb89, Vol. 51 Issue 1, p65; Subject Term: CHILD care; Subject Term: SCHOOL children; Subject Term: BROTHERS & sisters; Subject Term: MOTHERS; Subject Term: FAMILIES; Author-Supplied Keyword: Child Care and Welfare Services; Author-Supplied Keyword: CHILD WELFARE, PROBLEMS, AND TREATMENT; Author-Supplied Keyword: LATCHKEY CHILDREN; Number of Pages: 13p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Teti, Douglas M.
AU - Lamb, Michael E.
T1 - Socioeconomic and marital Outcomes of Adolescent Marriage, Adolescent Childbirth, and Their Co-occurrence.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1989/02//
VL - 51
IS - 1
M3 - Article
SP - 203
EP - 212
SN - 00222445
AB - The present study focuses upon socioeconomic and marital outcomes associated with adolescent marriage, adolescent childbirth, and their co-occurrence in a group of 30- to 55-year-old white and black women. The poorest socioeconomic outcomes were associated with adolescent childbirth regardless of the presence or timing of first marriage. However, women who had adolescent marriages without co-occurring adolescent childbirth still experienced socioeconomic deficits relative to women who never married nor gave birth and women who first married and gave birth as adults. Marital instability was associated with both adolescent marriage and adolescent childbirth, although more positive marital outcomes were experienced by women who both married and gave birth in adolescence than by women who married in adolescence but never had children. Results suggest that the degree of risk associated with the co-occurrence of adolescent marriage and adolescent childbirth is different from that associated with either event alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGE marriage
KW - SOCIOECONOMICS
KW - MARRIAGE
KW - CHILDBIRTH
KW - TEENAGERS
N1 - Accession Number: 5273978; Teti, Douglas M. 1 Lamb, Michael E. 2; Affiliation: 1: University of Maryland, Baltimore County 2: National Institute of Child Health and Human Development; Source Info: Feb89, Vol. 51 Issue 1, p203; Subject Term: TEENAGE marriage; Subject Term: SOCIOECONOMICS; Subject Term: MARRIAGE; Subject Term: CHILDBIRTH; Subject Term: TEENAGERS; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oliveri, Mary Ellen
T1 - Family Assessment: Rationale, Methods, and Future Directions (Book).
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1989/02//
VL - 51
IS - 1
M3 - Book Review
SP - 268
EP - 269
SN - 00222445
AB - Reviews the book "Family Assessment: Rationale, Methods, and Future Directions," by Theodore Jacob and Daniel L. Tennenbaum.
KW - FAMILY assessment
KW - NONFICTION
KW - JACOB, Theodore
KW - TENNENBAUM, Daniel L.
KW - FAMILY Assessment (Book)
N1 - Accession Number: 5274016; Oliveri, Mary Ellen 1; Affiliation: 1: National Institute of Mental Health; Source Info: Feb89, Vol. 51 Issue 1, p268; Subject Term: FAMILY assessment; Subject Term: NONFICTION; Reviews & Products: FAMILY Assessment (Book); People: JACOB, Theodore; People: TENNENBAUM, Daniel L.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104756633
T1 - Continuing care: a major issue in cancer pain management.
AU - Ventafridda, V
Y1 - 1989/02//1989 Feb
N1 - Accession Number: 104756633. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686.
KW - Continuity of Patient Care
KW - Neoplasms -- Physiopathology
KW - Pain -- Therapy
KW - Primary Health Care
KW - Affective Symptoms -- Etiology
KW - Neoplasms -- Complications
KW - Social Adjustment
SP - 137
EP - 143
JO - Pain (03043959)
JF - Pain (03043959)
JA - PAIN
VL - 36
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0304-3959
AD - Division of Pain Therapy and Palliative Care, National Cancer Institute, Milan, Italy.
U2 - PMID: 2919099.
DO - 10.1016/0304-3959(89)90018-3
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-06495-053
AN - 2006-06495-053
AU - May, Conrad
AU - Rapoport, Stanley I.
T1 - Treating Alzheimer's Disease.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1989/02//
VL - 34
IS - 2
SP - 184
EP - 185
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06495-053. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: May, Conrad; Laboratory of Neurosdences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Alzheimer's Disease; Drug Therapy; Psychotherapeutic Techniques; Treatment. Classification: Neurological Disorders & Brain Damage (3297); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Crook, Thomas (Ed); Bartus, Raymond T. (Ed); Ferris, Steven (Ed); Gershon, Samuel (Ed). Treatment Development Strategies for Alzheimer's Disease=Madison, CT: Powley, 1986. 699 pp; 1986. Page Count: 2. Issue Publication Date: Feb, 1989.
AB - Reviews the book, Treatment Development Strategies for Alzheimer's Disease edited by Thomas Crook, Raymond T. Bartus, Steven Ferris, and Samuel Gershon (see record [rid]1986-98479-000[/rid]). The devastation that is Alzheimer's disease is at once so immutable and frighteningly commonplace; understandably, this has led to the avid search for a cure, even though its root cause is unknown. The contributors to this book have sought to address this need by presenting the available clues and discussing the lines of reasoning on which possible therapies might be based. The chapters are written from diverse perspectives regarding a vast spectrum of topics (from the well-known cholinergic hypothesis to the brave new world of neural implants). Actually, two broad themes are intertwined throughout the book: first, the complex and often unique considerations that must be taken into account in developing drugs for Alzheimer's disease patients and, second, specific therapeutic approaches. This book is highly recommended for investigators of Alzheimer's disease, particularly those contemplating conducting clinical trials. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment strategies
KW - therapeutic approaches
KW - drugs
KW - Alzheimers disease
KW - 1989
KW - Alzheimer's Disease
KW - Drug Therapy
KW - Psychotherapeutic Techniques
KW - Treatment
KW - 1989
U2 - Crook, Thomas (Ed); Bartus, Raymond T. (Ed); Ferris, Steven (Ed); Gershon, Samuel (Ed). (1986); Treatment Development Strategies for Alzheimer's Disease; Madison, CT: Powley, 1986. 699 pp; 0-943378-05-2 (Paperback).
DO - 10.1037/027683
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06495-053&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Long-term Vasodilator Therapy Effective in Chronic Aortic Insufficiency.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/03/
VL - 261
IS - 5
M3 - Article
SP - 680
EP - 680
SN - 00987484
AB - Reports that long-term vasodilator therapy is effective in chronic aortic insufficiency. Benefit on left ventricular size and function; Comparison between receiving oral hydralazine and placebo; Effects of short-term treatment.
KW - VASODILATORS
KW - HYDRALAZINE
KW - AORTIC valve insufficiency -- Treatment
N1 - Accession Number: 10949404; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: VASODILATORS; Subject Term: HYDRALAZINE; Subject Term: AORTIC valve insufficiency -- Treatment; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Abnormalities in Retinoblastoma Gene May Contribute to Other Malignancies.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/03/
VL - 261
IS - 5
M3 - Article
SP - 680
EP - 680
SN - 00987484
AB - Reports that abnormalities in retinoblastoma gene may contribute to other malignancies such as small cell lung cancer and breast cancer. Examination of the structure of the gene; Effects of its inactivation; Absence of retinoblastoma gene messenger RNA expression.
KW - RETINOBLASTOMA
KW - SMALL cell lung cancer
KW - BREAST cancer
KW - GENETIC aspects
N1 - Accession Number: 10949405; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: RETINOBLASTOMA; Subject Term: SMALL cell lung cancer; Subject Term: BREAST cancer; Subject Term: GENETIC aspects; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - New Research Findings in Arthritis.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/03/
VL - 261
IS - 5
M3 - Article
SP - 680
EP - 680
SN - 00987484
AB - Reveals various research findings in arthritis. Effects of sports activities during youth on osteoarthritis; Range of risk for swimming, football, baseball, basketball and running; Comparison between older and younger patients with respect to responses to slow-acting antirheumatic drugs.
KW - ARTHRITIS
KW - MEDICAL research
KW - SPORTS
KW - ANTIRHEUMATIC agents
N1 - Accession Number: 10949406; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p680; Subject Term: ARTHRITIS; Subject Term: MEDICAL research; Subject Term: SPORTS; Subject Term: ANTIRHEUMATIC agents; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Roper, Maryann
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/03/
VL - 261
IS - 5
M3 - Letter
SP - 695
EP - 696
SN - 00987484
AB - Presents a letter to the editor regarding the National Cancer Institute's clinical alert on node-negative breast cancer.
KW - LETTERS to the editor
KW - BREAST cancer
N1 - Accession Number: 10949413; Roper, Maryann 1; Affiliation: 1: National Cancer Institute; Source Info: 2/3/89, Vol. 261 Issue 5, p695; Subject Term: LETTERS to the editor; Subject Term: BREAST cancer; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schlom, Jeffrey
T1 - Innovations in Monoclonal Antibody Tumor Targeting.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/03/
VL - 261
IS - 5
M3 - Article
SP - 744
EP - 746
SN - 00987484
AB - Reveals the diagnostic and therapeutic implications of innovations in monoclonal antibody tumor targeting. Case of a 33-year-old woman presented with a history of infertility; Ways to attack human carcinomas therapeutically; Use of iodine and dose fractionation.
KW - MONOCLONAL antibodies -- Therapeutic use
KW - CANCER -- Diagnosis
KW - INFERTILITY
N1 - Accession Number: 10949443; Schlom, Jeffrey 1; Affiliation: 1: National Institutes of Health; Source Info: 2/3/89, Vol. 261 Issue 5, p744; Subject Term: MONOCLONAL antibodies -- Therapeutic use; Subject Term: CANCER -- Diagnosis; Subject Term: INFERTILITY; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mattson, Margaret E.
AU - Boyd, Gayle
AU - Byar, David
AU - Brown, Charles
AU - Callahan, James F.
AU - Corle, Donald
AU - Cullen, Joseph W.
AU - Greenblatt, Janet
AU - Haley, Nancy J.
AU - Hammond, S. Katharine
AU - Lewtas, Joellen
AU - Reeves, Warren
T1 - Passive Smoking on Commercial Airline Flights.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/10/
VL - 261
IS - 6
M3 - Article
SP - 867
EP - 872
SN - 00987484
AB - Studies the effects of passive smoking on the health of commercial airline passengers. Assessment of in-flight exposure to nicotine, urinary cotinine levels and symptom self reports; Relationship of tobacco smoke levels with cotinine amounts in urine of passengers and attendants; Link between nicotine exposure and changes in eye and nose symptoms; Effect of nicotine exposure on passenger annoyance and smoke levels.
KW - SMOKING
KW - AIR travel
KW - NICOTINE
KW - URINALYSIS
KW - CIGARETTE smoke
N1 - Accession Number: 10949671; Mattson, Margaret E. 1 Boyd, Gayle 1 Byar, David 1 Brown, Charles 1 Callahan, James F. 1 Corle, Donald 1 Cullen, Joseph W. 1 Greenblatt, Janet 2 Haley, Nancy J. 3 Hammond, S. Katharine 4 Lewtas, Joellen 5 Reeves, Warren 6; Affiliation: 1: National Cancer Institute, Md 2: Prospect Associates, Md 3: American Health Foundation, NY 4: University of Massachusetts Medical School, Worcester 5: Environmental Protection Agency, NC 6: Air Canada, Montreal; Source Info: 2/10/89, Vol. 261 Issue 6, p867; Subject Term: SMOKING; Subject Term: AIR travel; Subject Term: NICOTINE; Subject Term: URINALYSIS; Subject Term: CIGARETTE smoke; NAICS/Industry Codes: 481211 Nonscheduled Chartered Passenger Air Transportation; NAICS/Industry Codes: 481111 Scheduled Passenger Air Transportation; NAICS/Industry Codes: 481110 Scheduled air transportation; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wingfield, Paul
AU - Graber, Pierre
AU - Shaw, Alan R.
AU - Gronenborn, Angela M.
AU - Clore, G. Marius
AU - MacDonald, H. Robson
T1 - Preparation, characterization and application of interleukin-1β mutant proteins with surface-accessible cysteine residues.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/02/15/
VL - 179
IS - 3
M3 - Article
SP - 565
EP - 571
PB - Wiley-Blackwell
SN - 00142956
AB - Two mutants of interleukin-1β (K27C and K138C) were produced using site-specific mutagenesis in which lysine residues at positions 27 and 138 of the mature protein sequence were substituted by cysteine residues. The conformations of the mutant proteins were studied by ¹H-NMR spectroscopy and shown to be similar to the wild-type protein. The receptor-binding affinity and biological activity of K27C and K138C were also similar to wild-type protein. The substituted cysteines in both mutant proteins were shown to be solvent-accessible as judged by their reactivity towards sulfhydryl reagents. As the wild-type protein contains two cysteines, which are both solvent-inaccessible in the native state, the mutants offer the opportunity to introduce probes in a sequence-specific manner via reaction with sulfhydryl groups. Examples of this are described in which the K138C was disulfide-linked to phycobiliproteins. The highly fluorescent conjugates had similar receptor-binding affinities to that of the wild-type unconjugated protein and were found suitable for flow-cytometric analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKINS
KW - PROTEINS
KW - MUTAGENESIS
KW - FLOW cytometry
KW - NUCLEAR magnetic resonance spectroscopy
KW - AMINO acid sequence
N1 - Accession Number: 13725234; Wingfield, Paul 1 Graber, Pierre 1 Shaw, Alan R. 1 Gronenborn, Angela M. 2 Clore, G. Marius 2 MacDonald, H. Robson 3; Affiliation: 1: Glaxo Institute for Molecular Biology S.A., Geneva 2: Laboratory of Chemical Physics. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 3: Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges; Source Info: 2/15/89, Vol. 179 Issue 3, p565; Subject Term: INTERLEUKINS; Subject Term: PROTEINS; Subject Term: MUTAGENESIS; Subject Term: FLOW cytometry; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: AMINO acid sequence; Number of Pages: 7p; Document Type: Article
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DB - aph
ER -
TY - JOUR
ID - 106711058
T1 - Behavioral, social and mental health aspects of home care for older Americans.
AU - Harper MS
Y1 - 1989/02/22/
N1 - Accession Number: 106711058. Language: English. Entry Date: 20040312. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128.
KW - Home Health Care -- Trends -- In Old Age
KW - Mental Disorders -- In Old Age
KW - Social Behavior Disorders -- In Old Age
KW - Accidental Falls -- Epidemiology
KW - Aged
KW - Aged, 80 and Over
KW - Delirium -- Epidemiology
KW - Dementia -- Epidemiology
KW - Dementia -- Etiology
KW - Depression -- Epidemiology
KW - Drug Interactions
KW - Drugs -- Adverse Effects
KW - Elder Abuse -- Epidemiology
KW - Female
KW - Geriatric Assessment
KW - Male
KW - Suicide -- Epidemiology
KW - Suicide -- Risk Factors
KW - Wandering Behavior
SP - 61
EP - 124
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 9
IS - 4
PB - Taylor & Francis Ltd
AB - Ninety-five percent (95 percent) of the elderly live in the community. At least five million of them need help with activities of daily living. Eighty percent have one or more chronic illness. Eighteen to 25 percent of the elderly have significant mental symptomatology. Only four percent of the elderly visit the community mental health centers (Ernst 1977; Talbott 1985). The primary providers of mental health services to the elderly are the general practitioners, the primary health care nurse, the home health aide psychiatric social workers, members of the family, and a few clinical geropsychologists (German 1987). Over half of the home health care clients are elderly. The primary home health care providers are 'challenged' in providing comprehensive health services to the elderly in their homes--often because of a lack of training of the primary home health care provider or because of lack of access because of agencies' policies regarding the acceptance of patients with behavioral, social and mental disorders, including Alzheimer's disease. In this paper, I have profiled the behavioral, social and mental health needs of the elderly with physical illnesses as well as those with behavioral, social and mental disorders. I have dealt with those specific conditions which home health care providers and families find specifically challenging and worrisome, namely: Delirium (confusional states) Suicidal ideation and attempts Psychological assessment Dementia of Alzheimer's type Depression Delirium: (confusion and other behavioral problems associated with hip fractures) Psychotropic drug interaction Wandering Every effort must be made to respect the privacy of the elderly, protect the elderly from research risk, get informed consent when indicated, provide counseling and always assure a high quality of care and supervision. There must be a current plan of care in which both the patient and family participate when feasible. Every effort and plan of care must focus on the maintenance of independence and self-care capabilities and prevention of excessive disabilities.
SN - 0162-1424
AD - Coordinator, Long Term Care Programs, Mental Disorder of Aging Research Branch, National Institute of Mental Health, U.S. Department of Health & Human Services, Rockville, MD
U2 - PMID: 10303290.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Quinn, Thomas C.
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/24/
VL - 261
IS - 8
M3 - Letter
SP - 1148
EP - 1149
SN - 00987484
AB - Responds to a letter to the editor of the 'Journal of the American Medical Association,' about the specificity and sensitivity of the rapid latex agglutination assay used in diagnosing HIV infections.
KW - AGGLUTINATION tests
KW - HIV infections -- Diagnosis
KW - MEDICAL screening
KW - DIAGNOSIS
KW - LETTERS to the editor
N1 - Accession Number: 10867237; Quinn, Thomas C. 1; Affiliation: 1: National Institute of Allergy and Infectious Diseases, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1148; Subject Term: AGGLUTINATION tests; Subject Term: HIV infections -- Diagnosis; Subject Term: MEDICAL screening; Subject Term: DIAGNOSIS; Subject Term: LETTERS to the editor; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Merril, Carl R.
AU - Harrington, Michael G.
AU - Sunderland, Trey
AU - Merril, C R
AU - Harrington, M G
AU - Sunderland, T
T1 - Plasma dehydroepiandrosterone levels in HIV infection.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/24/
VL - 261
IS - 8
M3 - letter
SP - 1149
EP - 1149
SN - 00987484
AB - Presents a letter to the editor of the 'Journal of the American Medical Association,' about the possible influence on dehydroepiandrosterone of infections with HIV.
KW - DEHYDROEPIANDROSTERONE
KW - HIV infections
KW - COMMUNICABLE diseases
KW - LETTERS to the editor
KW - AGE distribution (Demography)
KW - ANIMALS
KW - HIV seroconversion
N1 - Accession Number: 10867238; Merril, Carl R. 1 Harrington, Michael G. 1 Sunderland, Trey 1 Merril, C R Harrington, M G Sunderland, T; Affiliation: 1: National Institute of Mental Health, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1149; Subject Term: DEHYDROEPIANDROSTERONE; Subject Term: HIV infections; Subject Term: COMMUNICABLE diseases; Subject Term: LETTERS to the editor; Subject Term: AGE distribution (Demography); Subject Term: ANIMALS; Subject Term: HIV seroconversion; Number of Pages: 1p; Document Type: letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wittes, Robert E.
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/24/
VL - 261
IS - 8
M3 - Letter
SP - 1151
EP - 1151
SN - 00987484
AB - Presents a letter to the editor of the 'Journal of the American Medical Association,' about the financial aspects of clinical trials.
KW - CLINICAL trials
KW - MEDICAL experimentation on humans
KW - MEDICAL economics
KW - LETTERS to the editor
KW - ECONOMIC aspects
N1 - Accession Number: 10867245; Wittes, Robert E. 1; Affiliation: 1: National Cancer Institute, Md; Source Info: 2/24/89, Vol. 261 Issue 8, p1151; Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: MEDICAL economics; Subject Term: LETTERS to the editor; Subject Term: ECONOMIC aspects; Number of Pages: 1/5p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shimokata, Hiroshi
AU - Muller, Denis C.
AU - Andres, Reubin
T1 - Studies in the Distribution of Body Fat.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/02/24/
VL - 261
IS - 8
M3 - Article
SP - 1169
EP - 1173
SN - 00987484
AB - Examines cross-sectional associations between smoking habits, body mass index and waist-hip ratio (WHR) in men. Finding that weight and body mass index were significantly lower in cigarette smokers; Increase in the WHR of those who started smoking despite their loss of weight; Harmful effects of cigarette smoking on the pattern of distribution of body fat.
KW - FAT
KW - TOBACCO -- Physiological effect
KW - CIGARETTE smokers
KW - MEN -- Physiology
N1 - Accession Number: 10867257; Shimokata, Hiroshi 1 Muller, Denis C. 1 Andres, Reubin 1; Affiliation: 1: Laboratory of Clinical Physiology, Gerontology Research Center, National Institute on Aging, National Institute of Health, Baltimore; Source Info: 2/24/89, Vol. 261 Issue 8, p1169; Subject Term: FAT; Subject Term: TOBACCO -- Physiological effect; Subject Term: CIGARETTE smokers; Subject Term: MEN -- Physiology; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Furue, Masutaka
AU - Katz, Stephen I.
T1 - Direct Effects of Glucocorticosteroids on Epidermal Langerhans Cells.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/03//
VL - 92
IS - 3
M3 - Article
SP - 342
EP - 347
SN - 0022202X
AB - To determine the direct effects of glucocorticosteroids on epidermal Langerhans cells (LC), we treated isolated LC with dexarnethasone (DEX) in vitro, and investigated Ia expression by LC using immunofluorescence microscopy and FACS analysis. We found that DEX directly decreased the number of Ia+ LC in a dose-and time-dependent manner. Pulse incubation with DEX also inhibited the immunostimulatory function of LC in vitro. FACS analysis demonstrated that LC detected in DEX-treated culture expressed a similar amount of Ia antigen and Fc receptor on the cell surface as LC cultured with the solvent control, suggesting that LC may be composed of a heterogeneous population in terms of sensitivity to DEX, and DEX may completely abolish the expression of surface molecules on a subpopulation of LC or may be cytolytic to this sensitive population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADRENOCORTICAL hormones
KW - LANGERHANS cells
KW - MICROSCOPY
KW - ANTIGENS
KW - CELL membranes
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 12277165; Furue, Masutaka 1 Katz, Stephen I. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1989, Vol. 92 Issue 3, p342; Subject Term: ADRENOCORTICAL hormones; Subject Term: LANGERHANS cells; Subject Term: MICROSCOPY; Subject Term: ANTIGENS; Subject Term: CELL membranes; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277165
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCrae, Robert R.
AU - Costa Jr., Paul T.
T1 - Reinterpreting the Myers-Briggs Type Indicator From the Perspective of the Five-Factor Model of Personality.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1989/03//
VL - 57
IS - 1
M3 - Article
SP - 17
EP - 40
PB - Wiley-Blackwell
SN - 00223506
AB - The Myers-Briggs Type Indicator (MBTI, Myers & McCaulley, 1985) was evaluated from the perspectives of Jung's theory of psychological types and the five-factor model of personality as measured by self-reports and peer ratings on the NEO Personality Inventory (NEO-PI, Costa & McCrae, 1985b) Data were provided by 267 men and 201 women ages 19 to 93 Consistent with earlier research and evaluations, there was no support for the view that the MBTI measures truly dichotomous preferences or qualitatively distinct types, instead, the instrument measures four relatively independent dimensions The interpretation of the Judging--Perceiving index was also called into question The data suggest that Jung's theory is either incorrect or inadequately operationalized by the MBTI and cannot provide a sound basis for interpreting it However, correlational analyses showed that the four MBTI indices did measure aspects of four of the five major dimensions of normal personality The five-factor model provides an alternative basis for interpreting MBTI findings within a broader, more commonly shared conceptual framework [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Personality is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYERS-Briggs Type Indicator
KW - PSYCHOLOGY
KW - PEER review (Professional performance)
KW - PERSONALITY tests
KW - SELF-evaluation
KW - CORRELATION (Statistics)
N1 - Accession Number: 8972588; McCrae, Robert R. 1 Costa Jr., Paul T. 1; Affiliation: 1: Gerontology Research Center, National Institute on Aging, NIH.; Source Info: Mar89, Vol. 57 Issue 1, p17; Subject Term: MYERS-Briggs Type Indicator; Subject Term: PSYCHOLOGY; Subject Term: PEER review (Professional performance); Subject Term: PERSONALITY tests; Subject Term: SELF-evaluation; Subject Term: CORRELATION (Statistics); Number of Pages: 24p; Document Type: Article
L3 - 10.1111/1467-6494.ep8972588
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Follmann, Dean A.
AU - Lambert, Diane
T1 - Generalizing Logistic Regression by Nonparametric Mixing.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1989/03//
VL - 84
IS - 405
M3 - Article
SP - 295
SN - 01621459
AB - Logistic regression is a common technique for analyzing the effect of a covariate vector x on the number of successes y in m trials when y has a binomial distribution. But at times either the logistic curve does not describe the probability of success p(x) adequately, or m is larger than 1 and y is more variable than the binomial distribution allows. Overdispersion relative to the binomial distribution is possible if the m trials in a set or "litter" are positively correlated, an important covariate is omitted, or x is measured with error. A simple way to accommodate departures from the logit link and overdispersion is to introduce a random intercept alpha and thus permit a random propensity toward success. When alpha varies between individual binary trials according to a discrete or multimodal distribution, p(x) has smooth steps and y has a binomial(m, p(x)) distribution. When the random a is constant for a set of m binary trials and varies between sets of m trials according to a discrete or multimodal distribution, p(x) has smooth steps and y is overdispersed relative to the binomial distribution. In this article the distribution of a is left unspecified and estimated by nonparametric maximum likelihood. The estimated distribution of a is discrete, so the distribution of y and all of its properties are easily estimated for any x. Two examples are considered. In the first, the logit link is inadequate, but y appears to be binomial. Hence a is allowed to vary between binary trials. In the second, y's (with m > 1) from the same design point are more dispersed than the binomial distribution would predict, and there are outliers. Allowing alpha to vary randomly between sets of m trials accounts for the overdispersion and seems to temper the... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of covariance
KW - REGRESSION analysis
KW - DISTRIBUTION (Probability theory)
KW - PROBABILITY theory
KW - LOGISTIC regression analysis
KW - BINOMIAL distribution
KW - VARIABLES (Mathematics)
KW - BINOMIAL theorem
KW - Extrabinomial variability
KW - Link
KW - Logit mixture
KW - Overdispersion.
N1 - Accession Number: 4608698; Follmann, Dean A. 1; Lambert, Diane 2; Affiliations: 1: Mathematical Statistician, Biostatistics Re- search Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892.; 2: Member of Technical Staff, AT&T Bell Laboratories, Murray Hill NJ 07974.; Issue Info: Mar1989, Vol. 84 Issue 405, p295; Thesaurus Term: ANALYSIS of covariance; Thesaurus Term: REGRESSION analysis; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: PROBABILITY theory; Subject Term: LOGISTIC regression analysis; Subject Term: BINOMIAL distribution; Subject Term: VARIABLES (Mathematics); Subject Term: BINOMIAL theorem; Author-Supplied Keyword: Extrabinomial variability; Author-Supplied Keyword: Link; Author-Supplied Keyword: Logit mixture; Author-Supplied Keyword: Overdispersion.; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 104755237
T1 - Raising the profile of epidemiological research: discussion paper.
AU - Roth, C A
AU - Lenfant, C
Y1 - 1989/03//
N1 - Accession Number: 104755237. Language: English. Entry Date: 20110610. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879.
KW - Epidemiology
KW - Research
KW - National Institutes of Health (U.S.)
KW - Peer Review
KW - Research Support
KW - United States
SP - 147
EP - 150
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
JA - J R SOC MED
VL - 82
IS - 3
PB - Sage Publications, Ltd.
SN - 0141-0768
AD - National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892.
U2 - PMID: 2704013.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104755323
T1 - Phenytoin in reflex sympathetic dystrophy.
AU - Chaturvedi, S K
Y1 - 1989/03//1989 Mar
N1 - Accession Number: 104755323. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686.
KW - Phenytoin -- Therapeutic Use
KW - Reflex Sympathetic Dystrophy -- Drug Therapy
KW - Adult
KW - Male
KW - Pain -- Etiology
KW - Reflex Sympathetic Dystrophy -- Complications
SP - 379
EP - 380
JO - Pain (03043959)
JF - Pain (03043959)
JA - PAIN
VL - 36
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0304-3959
AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
U2 - PMID: 2710566.
DO - 10.1016/0304-3959(89)90099-7
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wyatt, Richard G.
T1 - Inactivating the Pertussis Toxin.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/03/
VL - 261
IS - 9
M3 - Article
SP - 1260
EP - 1260
SN - 00987484
AB - Reports on findings of a study of the enzymatic activity of the S1 subunit of the pertussis toxin molecule, conducted by scientists at the National Institute of Allergy and Infectious Diseases' Rocky Mountain Laboratories in Hamilton, Montana, in collaboration with researchers from Amgen Inc. and Japanese National Institute of Health. Site-specific mutation; Effects of deleting a part of the genetic region coding for the S1.
KW - PERTUSSIS toxin
KW - GENETIC code
KW - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW - AMGEN Inc.
N1 - Accession Number: 10975853; Wyatt, Richard G. 1; Affiliation: 1: National Institutes of Health; Source Info: 3/3/89, Vol. 261 Issue 9, p1260; Subject Term: PERTUSSIS toxin; Subject Term: GENETIC code; Company/Entity: NATIONAL Institute of Allergy & Infectious Diseases (U.S.) DUNS Number: Ticker: Company/Entity: AMGEN Inc. DUNS Number: 039976196 Ticker: AMGN; Number of Pages: 1/8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hughes, John R.
AU - Gust, Steven W.
AU - Keenan, Robert M.
AU - Fenwick, James W.
AU - Healey, Margaret L.
T1 - Nicotine vs Placebo Gum in General Medical Practice.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/03/
VL - 261
IS - 9
M3 - Article
SP - 1300
EP - 1305
SN - 00987484
AB - Reports on findings of a study of pharmacologic effects of nicotine gum to increase smoking cessation. Study design; Point prevalence abstinence rates; Internal validity checks; Predictors of outcome; Prevalence of side effects with nicotine than placebo gum.
KW - SMOKING cessation products
KW - SMOKING cessation
KW - TOBACCO use -- Prevention
KW - HEALTH products
N1 - Accession Number: 10975882; Hughes, John R. 1 Gust, Steven W. 2 Keenan, Robert M. 3 Fenwick, James W. 4 Healey, Margaret L. 5; Affiliation: 1: Departments of Psychiatry, Psychology, and Family Practice, University of Vermont, Burlington 2: National Institute on Drug Abuse, Washington, DC 3: Department of Psychiatry, University of Minnesota 4: Department of Mathematics and Statistics, University of Vermont, Burlington 5: Park-Nicollet Medical Foundation, Minneapolis; Source Info: 3/3/89, Vol. 261 Issue 9, p1300; Subject Term: SMOKING cessation products; Subject Term: SMOKING cessation; Subject Term: TOBACCO use -- Prevention; Subject Term: HEALTH products; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621990 All other ambulatory health care services; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siraganian, Patricia A.
AU - Mulvihill, John J.
AU - Mulivor, Richard A.
AU - Miller, Robert W.
T1 - Benign Familial Hyperphosphatasemia.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/03/
VL - 261
IS - 9
M3 - Article
SP - 1310
EP - 1312
SN - 00987484
AB - Studies a family with benign hyperphosphatasemia to determine the genetics and enzyme defect. Student subjects and methods; Genes code for serum alkaline phosphatase (ALP) activity suggesting bone or liver disease; Physiological substrates; Effects of benign elevations of serum ALP activity; Mode of inheritance for benign hyperphosphatasemia in the family.
KW - ALKALINE phosphatase
KW - FAMILIAL diseases
KW - BONES -- Diseases
KW - LIVER diseases
KW - GENETIC aspects
N1 - Accession Number: 10975884; Siraganian, Patricia A. 1 Mulvihill, John J. 1 Mulivor, Richard A. 2 Miller, Robert W. 1; Affiliation: 1: Clinical Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 2: Conell Institute for Medical Research, Camden, NJ; Source Info: 3/3/89, Vol. 261 Issue 9, p1310; Subject Term: ALKALINE phosphatase; Subject Term: FAMILIAL diseases; Subject Term: BONES -- Diseases; Subject Term: LIVER diseases; Subject Term: GENETIC aspects; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoofnagle, Jay H.
T1 - Type D (Delta) Hepatitis.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/03/
VL - 261
IS - 9
M3 - Article
SP - 1321
EP - 1325
SN - 00987484
AB - Reports on the case of a 40-year-old man with type D hepatitis. Medical history of the patient; Background on hepatitis delta virus (HDV); Clinical course of HDV; Difficulty in the diagnosis of HDV; Epidemiology of delta hepatitis; Association between delta hepatitis and type B hepatitis.
KW - HEPATITIS D
KW - DELTA-associated agent
KW - HEPATITIS B
KW - HEPATITIS
N1 - Accession Number: 10975886; Hoofnagle, Jay H. 1; Affiliation: 1: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md; Source Info: 3/3/89, Vol. 261 Issue 9, p1321; Subject Term: HEPATITIS D; Subject Term: DELTA-associated agent; Subject Term: HEPATITIS B; Subject Term: HEPATITIS; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Landesman, Sheldon H.
AU - Minkoff, Howard L.
AU - Willoughby, Anne
T1 - HIV Disease in Reproductive Age Women: A Problem of the Present.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/03/
VL - 261
IS - 9
M3 - Editorial
SP - 1326
EP - 1327
SN - 00987484
AB - Editorial. Discusses the human immunodeficiency virus (HIV) disease in reproductive age women. Ratio of births to an HIV-infected women in New York City; Selwyn and colleagues' prospective evaluation of pregnancies among drug-using seropositive and seronegative women; Consequences of HIV infection in pregnant women.
KW - HIV (Viruses)
KW - HIV infections
KW - HIV-positive women
KW - PREGNANCY complications
N1 - Accession Number: 10975887; Landesman, Sheldon H. 1 Minkoff, Howard L. 1 Willoughby, Anne 2; Affiliation: 1: State University of New York, Health Science Center, Brooklyn, NY 2: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Source Info: 3/3/89, Vol. 261 Issue 9, p1326; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: HIV-positive women; Subject Term: PREGNANCY complications; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolkowitz, Owen M.
AU - Rapaport, Mark
AU - Wolkowitz, O M
T1 - Long-lasting behavioral changes following prednisone withdrawal.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/03/24/
VL - 261
IS - 12
M3 - case study
SP - 1731
EP - 1732
SN - 00987484
AB - Examines cases of long-lasting behavioral changes following prednisone withdrawal. Clinical manifestations; Diagnostic findings; Treatment.
KW - PREDNISONE
KW - PSYCHOPHARMACOLOGY
N1 - Accession Number: 10867313; Wolkowitz, Owen M. 1 Rapaport, Mark 2 Wolkowitz, O M; Affiliation: 1: Langley Porter Psychiatric Institute, University of California 2: National Institute of Mental Health; Source Info: 3/24/89-3/31/89, Vol. 261 Issue 12, p1731; Subject Term: PREDNISONE; Subject Term: PSYCHOPHARMACOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: case study
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huff, J. E.
T1 - UNDERSTANDING CANCER.
JO - BioScience
JF - BioScience
Y1 - 1989/04//
VL - 39
IS - 4
M3 - Book Review
SP - 266
EP - 267
SN - 00063568
AB - Reviews the book 'Dimensions of Cancer,' by C. E. Kupchella.
KW - Cancer
KW - Nonfiction
KW - Kupchella, C. E.
KW - Dimensions of Cancer (Book)
N1 - Accession Number: 10100627; Huff, J. E. 1; Affiliations: 1: National Institutes of Health, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709; Issue Info: Apr89, Vol. 39 Issue 4, p266; Subject Term: Cancer; Subject Term: Nonfiction; Reviews & Products: Dimensions of Cancer (Book); People: Kupchella, C. E.; Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 569
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kostiuk, Peter F.
AU - Follmann, Dean A.
T1 - Learning Curves, Personal Characteristics, and Job Performance.
JO - Journal of Labor Economics
JF - Journal of Labor Economics
Y1 - 1989/04//
VL - 7
IS - 2
M3 - Article
SP - 129
PB - University of Chicago Press
SN - 0734306X
AB - Data on Naval Reserve recruiters are used to estimate the effects of on-the-job learning, experience, and individual characteristics on job performance. Generalizations of the Poisson distribution form the basis for estimating the effects of explanatory variables and control for individual heterogeneity and overdispersion. The findings show strong learning effects during the first 2 years on the job. Furthermore, lower pay-grade individuals have steeper learning curves than individuals in higher pay grades. Estimates of individual differences in productivity show a large variance in unobserved ability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Labor Economics is the property of University of Chicago Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYEE training
KW - JOB performance
KW - DISTRIBUTION (Probability theory)
KW - VARIANCES
KW - WAGES
KW - ESTIMATION theory
KW - NAVAL reserves
KW - POISSON distribution
KW - PERFORMANCE
KW - RECRUITING & enlistment (Armed Forces)
N1 - Accession Number: 4661354; Kostiuk, Peter F. 1; Follmann, Dean A. 2; Affiliations: 1: Center for Naval Analyses.; 2: National Heart, Lung, and Blood Institute.; Issue Info: Apr89, Vol. 7 Issue 2, p129; Thesaurus Term: EMPLOYEE training; Thesaurus Term: JOB performance; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: VARIANCES; Thesaurus Term: WAGES; Thesaurus Term: ESTIMATION theory; Subject Term: NAVAL reserves; Subject Term: POISSON distribution; Subject Term: PERFORMANCE; Subject Term: RECRUITING & enlistment (Armed Forces); NAICS/Industry Codes: 611430 Professional and Management Development Training; Number of Pages: 18p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 104755418
T1 - Transdermal fentanyl for pain control in patients with cancer.
AU - Miser, A W
AU - Narang, P K
AU - Dothage, J A
AU - Young, R C
AU - Sindelar, W
AU - Miser, J S
Y1 - 1989/04//1989 Apr
N1 - Accession Number: 104755418. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686.
KW - Fentanyl -- Therapeutic Use
KW - Neoplasms -- Complications
KW - Pain -- Drug Therapy
KW - Administration, Transcutaneous
KW - Adolescence
KW - Adult
KW - Aged
KW - Chronic Disease
KW - Female
KW - Fentanyl -- Administration and Dosage
KW - Male
KW - Middle Age
KW - Pain -- Etiology
SP - 15
EP - 21
JO - Pain (03043959)
JF - Pain (03043959)
JA - PAIN
VL - 37
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0304-3959
AD - Pediatric Branch, National Cancer Institute, Bethesda, MD 20892.
U2 - PMID: 2726274.
DO - 10.1016/0304-3959(89)90148-6
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bickers, David R.
AU - Lowy, Douglas R.
T1 - Carcinogenesis: A Fifty-Year Historical Perspective.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/04/15/
VL - 92
M3 - Article
SP - 121S
EP - 131S
SN - 0022202X
AB - In recent years, the focus of carcinogenesis studies has shifted to mechanistic analyses and to the contribution of specific genes to tumorigenesis. These analyses have suggested that cutaneous carcinogenesis at the molecular level results after several identifiable genetic attentions have occurred in the cell. Thus model systems of cutaneous carcinogenesis, in which early studies provided strong evidence for cancer being a multistep process, are now identifying the specific genes whose alterations contribute to malignant conversion. This historically oriented review highlights these and related advances in understanding cutaneous carcinogenesis and suggests some questions that may be addressed in future studies.
KW - CARCINOGENESIS
KW - CANCER -- Study & teaching
KW - GENETIC disorders
KW - MOLECULAR biology
KW - BIOCHEMISTRY
KW - SKIN diseases
N1 - Accession Number: 13075095; Bickers, David R. 1 Lowy, Douglas R. 2; Affiliation: 1: Department of Dermatology, Case Western Reserve University, School of Medicine, Cleveland, Ohio. 2: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Apr89Supplement, Vol. 92, p121S; Subject Term: CARCINOGENESIS; Subject Term: CANCER -- Study & teaching; Subject Term: GENETIC disorders; Subject Term: MOLECULAR biology; Subject Term: BIOCHEMISTRY; Subject Term: SKIN diseases; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/1523-1747.ep13075095
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Laurence H.
AU - Katz, Stephen I.
AU - Moshell, Alan N.
T1 - NIH Centennial: The Influence of NIH on Dermatology Research Training.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/04/15/
VL - 92
M3 - Article
SP - 177S
EP - 178S
SN - 0022202X
AB - Dermatologists can improve the care of their patients only when there is progress in the fundamental and clinical sciences. The training grant and research grant programs of the U.S. National Institutes of Health (NIH) have played a most important role in the evolution of dermatology in the United States since World War II. NIH funds have been of incalculable benefit. Early progress in our specialty was shaped largely by a small number of individuals located in four or five privileged centers, where there was sufficient local financial support to provide full-time physicians, space, equipment, and supplies. In only two or three of these schools money was derived from private endowments which provided a great advantage in early development. Thirty-five years ago the majority of medical schools essentially had no programs in dermatology, a situation which is much improved today, but even now has not been satisfactorily resolved.
KW - DERMATOLOGISTS
KW - PUBLIC health -- United States
KW - SKIN diseases
KW - FEDERAL aid to medical care research
KW - FUNDRAISING
KW - UNITED States
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 13075543; Miller, Laurence H. 1 Katz, Stephen I. 2 Moshell, Alan N. 1; Affiliation: 1: Skin Diseases Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, Bethesda, Maryland, U.S.A. 2: Dermatology Branch, National Cancer Institute, Bethesda, Maryland, U.S.A.; Source Info: Apr89Supplement, Vol. 92, p177S; Subject Term: DERMATOLOGISTS; Subject Term: PUBLIC health -- United States; Subject Term: SKIN diseases; Subject Term: FEDERAL aid to medical care research; Subject Term: FUNDRAISING; Subject Term: UNITED States; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 813210 Grant-making and giving services; NAICS/Industry Codes: 813211 Grantmaking Foundations; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1523-1747.ep13075543
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linet, Martha S.
AU - Stewart, Walter F.
AU - Celentano, David D.
AU - Ziegler, Dewey
AU - Sprecher, Martha
T1 - An Epidemiologic Study of Headache Among Adolescents and Young Adults.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/04/21/
VL - 261
IS - 15
M3 - Article
SP - 2211
SN - 00987484
AB - Presents a population-based telephone interview study on headache among adolescents and young adults in Washington County, Maryland. Number of headaches reported in a span of four weeks; Selection of study subjects; Data culling and analysis; Characteristics of headaches.
KW - HEADACHE
KW - INTERVIEWING
KW - PAIN
KW - WASHINGTON County (Md.)
KW - MARYLAND
KW - UNITED States
N1 - Accession Number: 10868288; Linet, Martha S. 1,2 Stewart, Walter F. 1 Celentano, David D. 1 Ziegler, Dewey 3 Sprecher, Martha 1; Affiliation: 1: Department of Epidemiology, Division of Behavioral Sciences and Health Education and Health Education, Department of Health Policy and Management, The Hopkins University School of Hygiene and Public Health 2: Analytic Studies Section, Biostatic Branch, Epidemiology and Biostatics Program, Division of Cancer Etiology, National Cancer Institute 3: Department of Neurology, University of Kansas; Source Info: 4/21/89, Vol. 261 Issue 15, p2211; Subject Term: HEADACHE; Subject Term: INTERVIEWING; Subject Term: PAIN; Subject Term: WASHINGTON County (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bhathena, Sam J.
AU - Berlin, Elliott
AU - Judd, Joseph
AU - Nair, Padmanabhan P.
AU - Kennedy, Bruce W.
AU - Jones, Jacquelyn
AU - Smith, Patricia M.
AU - Jones, Yvonne
AU - Taylor, Philip R.
AU - Campbell, William S.
T1 - Hormones regulating lipid and carbohydrate metabolism in premenopausal women: modulation by dietary lipids.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/05//
VL - 49
IS - 5
M3 - Article
SP - 752
EP - 757
SN - 00029165
AB - The effect of high- and low-fat diets with different levels of fatty acid unsaturation on plasma hormones involved in lipid metabolism was studied during different phases of the menstrual cycle in 31 premenopausal women. Subjects were divided into two groups and were fed controlled diets containing 39% fat with a ratio of polyunsaturated to saturated fatty acids (P:S) of either 0.3 or 1.0 for four menstrual cycles and then switched to a 19% fat diet with the same P:S for another four cycles. Blood samples were analyzed during both the follicular and luteal phases. A significant direct effect of level of dietary fat was observed on plasma cortisol and dehydroepiandrosterone-sulphate whereas an inverse relationship was seen for plasma insulin. Both plasma insulin and growth hormone levels were higher during the luteal compared with the follicular phase of the menstrual cycle. None of the hormones was affected by the level of unsaturation of dietary fats. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lipid metabolism
KW - Carbohydrate metabolism
KW - Insulin
KW - Low-fat diet
KW - High-fat diet
KW - Saturated fatty acids
KW - Unsaturated fatty acids
KW - cortisol
KW - DHEA-S
KW - glucagon
KW - growth hormone
KW - high-fat diet
KW - low-fat diet
KW - menstrual cycle
KW - P: S
N1 - Accession Number: 91731627; Bhathena, Sam J. 1,2; Berlin, Elliott 1,2; Judd, Joseph 1,2; Nair, Padmanabhan P. 1,2; Kennedy, Bruce W. 1,2; Jones, Jacquelyn 1,2; Smith, Patricia M. 1,2; Jones, Yvonne 1,2; Taylor, Philip R. 1,2; Campbell, William S. 1,2; Affiliations: 1: Carbohydrate Nutrition Laboratory and the Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD; 2: Cancer Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD; Issue Info: May1989, Vol. 49 Issue 5, p752; Subject Term: Lipid metabolism; Subject Term: Carbohydrate metabolism; Subject Term: Insulin; Subject Term: Low-fat diet; Subject Term: High-fat diet; Subject Term: Saturated fatty acids; Subject Term: Unsaturated fatty acids; Author-Supplied Keyword: cortisol; Author-Supplied Keyword: DHEA-S; Author-Supplied Keyword: glucagon; Author-Supplied Keyword: growth hormone; Author-Supplied Keyword: high-fat diet; Author-Supplied Keyword: low-fat diet; Author-Supplied Keyword: menstrual cycle; Author-Supplied Keyword: P: S; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Amatayakul, Kosin
AU - Underwood, Barbara A.
AU - Ruckphaopunt, Somsri
AU - Singkamani, Ratree
AU - Linpisarn, Sukanya
AU - Leelapat, Posri
AU - Thanangkul, Ousa
T1 - Oral contraceptives: effect of long-term use on liver vitamin A storage assessed by the relative dose response test.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/05//
VL - 49
IS - 5
M3 - Article
SP - 845
EP - 848
SN - 00029165
AB - Vitamin A status measured by the relative dose response (RDR) test was determined among groups of Northern Thai women who had used estrogen-containing oral contraceptives (OCs) with or without multivitamin supplements through 13 cycles. Mean serum vitamin A values were elevated ~40% above those of control subjects (intrauterine contraceptive device (IUCD) users) during OC usage. Daily (one capsule) or periodic (two capsules 7 d/mo) multivitamin supplementation that included 1700 µg vitamin A per capsule did not significantly influence vitamin A serum values. The RDR test after 13 cycles was elevated in one individual who had taken OCs and the periodic multivitamin supplement. It reverted to normal after supplementation with vitamin A. A single high-dose vitamin A supplement (68 000 pg) did not change circulating levels of the vitamin. Among this population there is little evidence that use of estrogen-containing OCs for > 1 y resulted in a physiologically significant deterioration of vitamin A status. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vitamin A
KW - Oral contraceptives
KW - Intrauterine contraceptives
KW - Vitamins
KW - Liver
KW - assessment vitamin A status
KW - oral contraceptives
KW - RDR
N1 - Accession Number: 91731640; Amatayakul, Kosin 1,2,3; Underwood, Barbara A. 1,2,3; Ruckphaopunt, Somsri 1,2,3; Singkamani, Ratree 1,2,3; Linpisarn, Sukanya 1,2,3; Leelapat, Posri 1,2,3; Thanangkul, Ousa 1,2,3; Affiliations: 1: Research Institute for Health Sciences; 2: Department of Paediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 3: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: May1989, Vol. 49 Issue 5, p845; Subject Term: Vitamin A; Subject Term: Oral contraceptives; Subject Term: Intrauterine contraceptives; Subject Term: Vitamins; Subject Term: Liver; Author-Supplied Keyword: assessment vitamin A status; Author-Supplied Keyword: oral contraceptives; Author-Supplied Keyword: RDR; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ravussin, Eric
AU - Bogardus, Clifton
T1 - Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/05//
VL - 49
IS - 5
M3 - Article
SP - 968
EP - 975
SN - 00029165
AB - The article discusses the relationship of physical fitness, age and genetics to daily energy expenditure and fuel utilization. It notes the four components of 24-hour energy expenditure including the sleeping metabolic rate, thermic effect of food and the energy cost of physical activity. It mentions that basal metabolic rate has been proven to be correlated with body size and its small deficits or excess can add up to a large number of calories over time.
KW - Energy metabolism
KW - Caloric expenditure
KW - Physical fitness
KW - Aging
KW - Physical activity
KW - Basal metabolism
N1 - Accession Number: 91731665; Ravussin, Eric 1; Bogardus, Clifton 2; Affiliations: 1: Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ; 2: Department of Nutrition, Arizona State University, Tempe, AZ; Issue Info: May1989, Vol. 49 Issue 5, p968; Thesaurus Term: Energy metabolism; Subject Term: Caloric expenditure; Subject Term: Physical fitness; Subject Term: Aging; Subject Term: Physical activity; Subject Term: Basal metabolism; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenblum, Leonard A.
AU - Kummer, Hans
AU - Nadler, Ronald D.
AU - Robinson, John
AU - Suomi, Stephen J.
T1 - Interface of Field and Laboratory-Based Research in Primatology.
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1989/05//
VL - 18
IS - 1
M3 - Article
SP - 61
EP - 64
SN - 02752565
AB - The article focuses on a conference "Interface of Laboratory and Field Based Research in Primatology" which was convened by the National Institute of Child Health and Human Development through its Laboratory of Comparative Ethology, IRP. This conference was designed to identify means of bridging an apparent chasm that separates some primatologists working in the field from some whose research is carried out primarily in laboratory settings. There was a clear consensus among all the conference participants that such a separation represents a detriment to the discipline. Moreover, it was agreed that our ability to clarify perceived differences in philosophy and approach and to overcome any research obstacles generated by these differences will influence not only the future progress of primatology but also the applicability of our work to the broader domain of biology.
KW - PRIMATES
KW - CLERGY conferences
KW - PRIMATOLOGISTS
KW - PHILOSOPHY
KW - BIOLOGY
KW - NATIONAL Institute of Child Health & Human Development (U.S.)
N1 - Accession Number: 12341179; Rosenblum, Leonard A. 1 Kummer, Hans 2 Nadler, Ronald D. 3 Robinson, John 4 Suomi, Stephen J. 5; Affiliation: 1: Department of Psychiatry,SUNY Health Science Center at Brooklyn. 2: Institute of Zoology, University of Zurich. 3: Yerkes Regional Primate Center, Emory University, Atlanta, Georgia. 4: Program for Studies in Tropical Conservation, University of Florida, Gainesville. 5: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Bethesda, Maryland.; Source Info: 1989, Vol. 18 Issue 1, p61; Subject Term: PRIMATES; Subject Term: CLERGY conferences; Subject Term: PRIMATOLOGISTS; Subject Term: PHILOSOPHY; Subject Term: BIOLOGY; Company/Entity: NATIONAL Institute of Child Health & Human Development (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Corbin, Stephen B.
T1 - Fluoridation Then and Now.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/05//
VL - 79
IS - 5
M3 - Editorial
SP - 561
EP - 563
PB - American Public Health Association
SN - 00900036
AB - The author discusses on fluoridation of community water supplies as one of the most important public health measures. Fluoride has a substantial contribution to public health of all ages. The practice of fluoridating drinking water has grown dramatically and such undertakings reduced the prevalence of dental caries in children's teeth.
KW - WATER fluoridation
KW - DRINKING water
KW - PUBLIC health
KW - FLUORIDES
N1 - Accession Number: 4693435; Corbin, Stephen B. 1; Affiliation: 1: Disease Prevention Policy Analyst, National Institutes of Health, National Institute of Dental Research, Westwood Building, Room 538, 5333 Westbard Avenue, Bethesda, MD 20892; Source Info: May89, Vol. 79 Issue 5, p561; Subject Term: WATER fluoridation; Subject Term: DRINKING water; Subject Term: PUBLIC health; Subject Term: FLUORIDES; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moorman, Jeanne E.
AU - Hernandez, Donald J.
T1 - Married-Couple Families With Step, Adopted, and Biological Children.
JO - Demography
JF - Demography
Y1 - 1989/05//
VL - 26
IS - 2
M3 - Article
SP - 267
EP - 278
SN - 00703370
AB - National estimates of the numbers of families with step, adopted, and biological children have not previously been developed. In this work, parent types for children in married-couple families were indirectly identified by using marriage and birth dates. Families were then classified by the types of children present. A large majority (79 percent) had only biological children; however, a significant minority (16 percent) had at least one stepchild and 4 percent had at least one adopted child. This analysis provides national estimates of the numbers and characteristics of married-couple families with step, adopted, and biological children. [ABSTRACT FROM AUTHOR]
AB - Copyright of Demography is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUARDIAN & ward
KW - FAMILIES
KW - MARRIAGE
KW - ADOPTED children
KW - BIRTHFATHERS
KW - STEPCHILDREN
N1 - Accession Number: 16799722; Moorman, Jeanne E. 1; Hernandez, Donald J. 2; Affiliations: 1: National Institute on Drug Abuse, Division of Epidemiology and Statistical Analysis, 5600 Fishers Lane, Rockville, Maryland 20772; 2: Population Division, U.S. Bureau of the Census, Washington, D.C. 20233; Issue Info: May1989, Vol. 26 Issue 2, p267; Subject Term: GUARDIAN & ward; Subject Term: FAMILIES; Subject Term: MARRIAGE; Subject Term: ADOPTED children; Subject Term: BIRTHFATHERS; Subject Term: STEPCHILDREN; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Aoyama, Toshifumi
AU - Korzekwa, Kenneth
AU - Nagata, Kiyoshi
AU - Gillette, James
AU - Gelboin, Harry V.
AU - Gonzales, Frank J.
T1 - cDNA-directed expression of rat testosterone 7α-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6α-hydroxylation and Δ6-testosterone formation.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/05//5/1/89
VL - 181
IS - 2
M3 - Article
SP - 331
EP - 336
PB - Wiley-Blackwell
SN - 00142956
AB - The modified vaccinia virus, T7-RNA-polymerase cDNA-expression system was used to express rat cytochrome P-450a. Various parameters such as host-cell type and density, and duration of infection were tested to optimize the level of expression of cytochrome P-450a enzyme activity. Cytochrome P-450a expressed from the cDNA sequence was exclusively incorporated into the membrane-containing portions of the cell lysates, as expected from its normal association in the liver endoplasmic reticulum. The enzyme displayed a carbonmonoxide-reduced-cytochrome-P-450a difference spectrum with a Sorer maximum of 450 nm. Activity measurements revealed that cytochrome P-450a produced three metabolites of testosterone; 7α-hydroxytestosterone and 6α-hydroxytestosterone and Δ6-testosterone at a ratio of about 38:1:1. Under the appropriate conditions, the vaccinia-virus, T7-RNA-polymerase system produces high levels of a single form of cytochrome P-450 in cells that are virtually devoid of endogenous cytochrome P-450. Analysis of the cytochrome P-450 in its natural membrane-bound state, as opposed to artificial-lipid reconstitution studies of purified enzymes, allows accurate and confident measurements of substrate specificities. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINIA
KW - CATTLE -- Virus diseases
KW - CYTOCHROME P-450
KW - CYTOCHROMES
KW - DNA polymerases
KW - ENDOPLASMIC reticulum
N1 - Accession Number: 13795219; Aoyama, Toshifumi 1 Korzekwa, Kenneth 2 Nagata, Kiyoshi 2 Gillette, James 2 Gelboin, Harry V. 1 Gonzales, Frank J. 1; Affiliation: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda 2: Laboratory of Chemical Pharmacology, National Institutes of Heart, Lung and Blood, National Institutes of Health, Bethesda; Source Info: 5/1/89, Vol. 181 Issue 2, p331; Subject Term: VACCINIA; Subject Term: CATTLE -- Virus diseases; Subject Term: CYTOCHROME P-450; Subject Term: CYTOCHROMES; Subject Term: DNA polymerases; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Larson, David B.
AU - Lyons, John S.
AU - Hohmann, Ann A.
AU - Beardsley, Robert S.
AU - Huckeba, Wendy M.
AU - Rabins, Peter V.
AU - Lebowitz, Barry D.
T1 - A systematic review of nursing home research in three psychiatric journals: 1966–1985.
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
Y1 - 1989/05//
VL - 4
IS - 3
M3 - Article
SP - 129
EP - 134
PB - John Wiley & Sons, Inc.
SN - 08856230
AB - This article presents the results of a systematic review of two decades of research on nursing home populations in three major psychiatric journals. The review indicates that very little psychiatric research has been undertaken in nursing home settings. The work that has been done is more often qualitative: case studies, program reports or reviews of the research, rather than quantitative research studies. The small amount of empirical research that has been published has suffered from sampling, design, and analytic shortcomings. Until recently, there has been little funded psychiatric research in nursing home setting, reflected in a worse than average disapproval rate for NIMH grant submissions involving nursing home populations. The implications of this review are discussed and recommendations are made for advancing this area of study among mental health professionals. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities
KW - RESEARCH
KW - NURSING home patients
KW - PSYCHIATRIC research
KW - LONG-term care facilities
KW - GERIATRICS
KW - Nursing homes
KW - psychiatric disorders
KW - research methods
N1 - Accession Number: 23633528; Larson, David B. 1 Lyons, John S. 2 Hohmann, Ann A. 1 Beardsley, Robert S. 3 Huckeba, Wendy M. 4 Rabins, Peter V. 4 Lebowitz, Barry D. 1; Affiliation: 1: National Institute of Mental Health 2: Northwestern University Medical School 3: University of Maryland Pharmacy School 4: Johns Hopkins University; Source Info: May1989, Vol. 4 Issue 3, p129; Subject Term: NURSING care facilities; Subject Term: RESEARCH; Subject Term: NURSING home patients; Subject Term: PSYCHIATRIC research; Subject Term: LONG-term care facilities; Subject Term: GERIATRICS; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: psychiatric disorders; Author-Supplied Keyword: research methods; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hastings, Glare
AU - Muir-Nash, Joanne
T1 - Validation of a Taxonomy of Ambulatory Nursing Practice.
JO - Nursing Economic$
JF - Nursing Economic$
Y1 - 1989/05//May/Jun89
VL - 7
IS - 3
M3 - Article
SP - 142
EP - 149
PB - Jannetti Publications, Inc.
SN - 07461739
AB - The article discusses and focuses on the validation of a taxonomy of ambulatory nursing practice. Ambulatory care is considered to be a complex and challenging nursing specialty. Based on a survey of 33 ambulatory nursing administrators, roles and responsibilities of nurses in ambulatory care settings were addressed. Ambulatory care could be defined as care delivered to patients within a healthcare facility for those who do not stay overnight. The study provides a validated taxonomy which could be useful for managers, researchers and clinicians in order to develop patient classification systems.
KW - OUTPATIENT medical care
KW - TAXONOMY
KW - NURSING -- Practice
KW - MEDICAL care surveys
KW - NURSE practitioners
KW - PATIENTS
N1 - Accession Number: 12233087; Hastings, Glare 1 Muir-Nash, Joanne 2; Affiliation: 1: Director of Marketing and Communications, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD. 2: Clinical Nurse, Ambulatory Care, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD.; Source Info: May/Jun89, Vol. 7 Issue 3, p142; Subject Term: OUTPATIENT medical care; Subject Term: TAXONOMY; Subject Term: NURSING -- Practice; Subject Term: MEDICAL care surveys; Subject Term: NURSE practitioners; Subject Term: PATIENTS; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Functional Electrical Stimulation: An Overview.
AU - Hambrecht, F. Terry
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1989/05//
VL - 12
IS - 5
SP - 840
EP - 843
SN - 01478389
N1 - Accession Number: 17482606; Author: Hambrecht, F. Terry: 1 ; Author Affiliation: 1 National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, Bethesda, Maryland; No. of Pages: 4; Language: English; Publication Type: Article; Update Code: 20050706
N2 - The development of future neural prostheses involves much more than connecting commercially available stimulators to disabled individuals. Safe and effective operation of prostheses requires fundamental studies of the electrode-tissue interface. The electrochemistry of the interface must be controlled to prevent toxic byproducts. Histopathological studies of stimulated tissue are necessary to establish safe limits of stimulation and to determine mechanisms of neural damage when it does occur. Electrophysiological studies elucidate which neural pathways are excited and help in the design of more selective electrode arrays. Biomaterials are required that protect the implant from the hostile environment of the body. Presently available materials are being improved and totally new materials are being developed. One of the goals of neural prostheses developers is a nonhermetic packaging material that can be applied to miniature implants without appreciably increasing their size. The techniques used to make integrated circuits on silicone substrates are ideally suited to making ultraminiature electrodes with self-contained electronic signal processing. Both integrated circuit stimulating and recording electrodes are being designed and fabricated. ABSTRACT FROM AUTHOR
KW - *ELECTRIC stimulation
KW - *ELECTROPHYSIOLOGY
KW - *ELECTROTHERAPEUTICS
KW - ELECTRODES
KW - INTEGRATED circuits
KW - SILICONES
KW - biomaterials
KW - electrodes
KW - neural prostheses
KW - neural stimulation
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Taylor, Edward H.
T1 - Schizophrenia: Fire in the Brain.
JO - Social Work
JF - Social Work
Y1 - 1989/05//
VL - 34
IS - 3
M3 - Article
SP - 258
EP - 261
PB - Oxford University Press / USA
SN - 00378046
AB - The article comments on "Biological Basis of Schizophrenia: The Evidence Reconsidered," Social Work 34 (May 1989), by David Cohen. The article brings out the new findings associated with Schizophrenia. David Cohen summarized the biological basis of Schizophrenia into the following six broad concepts: (1) no single abnormality is associated only with schizophrenia; (2) computerized axial tomography (CAT) scans have limited importance; (3) findings are based on small samples; (4) schizophrenia is difficult to diagnose; (5) neuroleptic drugs change brain functions, produce damage, and cause multiple side effects such as tardive dyskinesia (TD); and (6) the biological argument is not new. Cohen is correct to assume that neuroleptic drugs complicate analysis of brain data and behavioral observations. However, the notion that neurological studies cannot be trusted if these medications have been taken is incorrect. (NIMH) studies document that observable psychotic symptoms become more intense during drug-free periods and decrease when neuroleptic drugs are administered.
KW - PSYCHIATRY
KW - BRAIN diseases
KW - SCHIZOPHRENIA
KW - ANTIPSYCHOTIC drugs
KW - PATHOLOGICAL psychology
KW - BRAIN -- Ventricles
N1 - Accession Number: 5281502; Taylor, Edward H. 1; Affiliation: 1: Clinical Social Worker, Neuroscience Research Center, National Institute of Mental Health, 2700 Martin Luther King, Jr., Avenue, SE, Washington, DC 20032.; Source Info: May89, Vol. 34 Issue 3, p258; Subject Term: PSYCHIATRY; Subject Term: BRAIN diseases; Subject Term: SCHIZOPHRENIA; Subject Term: ANTIPSYCHOTIC drugs; Subject Term: PATHOLOGICAL psychology; Subject Term: BRAIN -- Ventricles; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06498-064
AN - 2006-06498-064
AU - Tancer, Manuel E.
AU - Uhde, Thomas W.
T1 - Not All Anxieties are the Same.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1989/05//
VL - 34
IS - 5
SP - 512
EP - 512
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06498-064. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Tancer, Manuel E.; Unit on Anxiety and Affective Disorders, National Institute of Mental Health, Rockville, MD, US. Release Date: 20061204. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Anxiety Disorders; Treatment. Classification: Neuroses & Anxiety Disorders (3215); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Klein, D. F. (Ed); Fyer, A. J. (Ed); Gorman, J. M. (Ed); Liebowitz, M. R. (Ed). Anxiety=Basel, Switzerland: Karger, 1987. 195 pp. $65.00 (DM 117,-, SWF 98,-); 1987. References Available: Y. Page Count: 1. Issue Publication Date: May, 1989.
AB - Reviews the book, Anxiety by D. F. Klein (Ed.), A. J. Fyer, J. M. Gorman, and M. R. Liebowitz (1987). This book is a collection of papers written by researchers at the New York State Psychiatric Institute (NYSPl). The purpose of the collection, as stated is to share with the reader the 'current thinking of our research group about the nature and treatment of anxiety disorders.' The book has numerous typographical errors and minor errors in the spelling of names in the citations that detract from the quality of the text. In summary, with the reservation that the information in the book has a definite slant, this book is a good introduction to the literature and provides an extremely useful historical viewpoint for the emergent but still controversial theory that panic attacks represent a distinct type of pathological anxiety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - anxiety disorders
KW - anxiety
KW - treatment
KW - 1989
KW - Anxiety
KW - Anxiety Disorders
KW - Treatment
KW - 1989
U2 - Klein, D. F. (Ed); Fyer, A. J. (Ed); Gorman, J. M. (Ed); Liebowitz, M. R. (Ed). (1987); Anxiety; Basel, Switzerland: Karger, 1987. 195 pp. $65.00 (DM 117,-, SWF 98,-); 3-8055-4488-X.
DO - 10.1037/028075
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Stover, Ellen
T1 - NIMH Seeks Research on AIDS and Mental Health.
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 1989///Summer1989
VL - 1
IS - 2
M3 - Article
SP - 166
EP - 166
SN - 08999546
AB - The article focuses on the efforts of the National Institute of Mental Health (NIMH) to seek applications for research on mental health and behavioral aspects HIV infection and AIDS. NIMH has requested research grants, some in cooperation with Public Health Service agencies. The research areas undertaken by the NIMH includes: (1) effect of HIV infection on the central nervous system; (2) relationships between the brain, the immune system, and aspects of HIV infection; (3) behavior change and prevention in the reduction of HIV transmission; (4) treatment of HIV-related mental disorders; (5) risk management of HIV infection; (6) research training for those who wish to study HIV infection; and (7) institutional research training programs to study HIV infection.
KW - AIDS (Disease)
KW - HIV infections
KW - Mental health
KW - Pathological psychology
KW - PREVENTION
KW - TRANSMISSION
KW - Medical research
KW - Public health administration
KW - Health services administration
KW - National Institute of Mental Health (U.S.)
N1 - Accession Number: 19720655; Stover, Ellen 1; Affiliations: 1: Acting AIDS Coordinator, National Institute of Mental Health, Room 17C-04, 5600 Fishers Lane Rockville, MD 20857; Issue Info: Summer1989, Vol. 1 Issue 2, p166; Thesaurus Term: AIDS (Disease); Subject Term: HIV infections; Subject Term: Mental health; Subject Term: Pathological psychology; Subject Term: PREVENTION; Subject Term: TRANSMISSION; Subject Term: Medical research; Subject Term: Public health administration; Subject Term: Health services administration ; Company/Entity: National Institute of Mental Health (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Micozzi, Marc S.
AU - Taylor, Philip R.
T1 - Reply to P Le François.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/06//
VL - 49
IS - 6
M3 - Letter to the Editor
SP - 1330
EP - 1331
SN - 00029165
AB - A response from the author on the comments of Le François on his article related to carotenodermia published in a 1988 issue of the periodical is presented.
KW - Skin diseases
KW - Carotenoids
N1 - Accession Number: 85657377; Micozzi, Marc S. 1; Taylor, Philip R. 2; Affiliations: 1: National Museum of Health and Medicine, Armed Forces Institute of Pathology, Washington, DC 20306-6000; 2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20854; Issue Info: Jun1989, Vol. 49 Issue 6, p1330; Subject Term: Skin diseases; Subject Term: Carotenoids; Number of Pages: 2p; Document Type: Letter to the Editor
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harris, Tamara
AU - Kovar, Mary Grace
AU - Suzman, Richard
AU - Kleinman, Joel C.
AU - Feldmam, Jacob J.
T1 - Longitudinal Study of Physical Ability in the Oldest-Old.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 698
EP - 702
PB - American Public Health Association
SN - 00900036
AB - Abstract: Based on 1984 data from the Longitudinal Study on Aging, one-third of White persons aged 80 or older living in the community (N = 1,791) were defined as having no difficulty in walking 1/4 of a mile, in lifting 10 pounds, in climbing 10 steps without resting, or in stooping, crouching or kneeling. Physical ability was associated with lower risk of death over two years mean follow-up; Relative odds (RO) = .4 (95 percent confidence interval = .4, .6) and in survivors, lower utilization of hospitals RO = .4 (CI = .3, .7), physicians RO = .6 (CI = .5, .8) and nursing homes RO = .3 (CI = .2, .5) compared with those having difficulty on any of the four functional measures included in the definition of physical ability. Fifty percent of the women and 42 percent of the men physically able at the time of the baseline survey in 1984 remained physically able at follow-up. Continued physical ability in this group was associated with never having had cardiovascular disease RO = 2.1, (CI = 1.2, 3.7), never having had arthritic complaints RO = 1.9 (CI = 1.2, 2.7), a body mass index < the 75th percentile (RO = 1.8 (CI = 1.2, 2.9), younger age (for each decade of age, RO = 2.0 (CI = 1.1, 3.6), and higher level of education (> 13 years versus 0-6 years) RO = 2.4 (CI = 1.2, 4.7). These correlates include factors amenable to preventive measures and highlight the need to consider the heterogeneity of the oldest-old in formulating programs aimed at prevention and postponement of disability. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GERIATRIC assessment
KW - PHYSICAL fitness testing
KW - OLDER people -- Physiology
KW - LONGITUDINAL method
KW - DISABILITY evaluation
KW - OLD age
KW - WALKING -- Physiological aspects
KW - AGING -- Physiological aspects
KW - WHITES
KW - PHYSIOLOGY
KW - PHYSIOLOGICAL aspects
N1 - Accession Number: 4695728; Harris, Tamara 1 Kovar, Mary Grace 1 Suzman, Richard 2 Kleinman, Joel C. 1 Feldmam, Jacob J. 1; Affiliation: 1: National Center for Health Statistics, Hyattsville, Maryland. 2: National Institute on Aging, Bethesda, Maryland.; Source Info: Jun89, Vol. 79 Issue 6, p698; Subject Term: GERIATRIC assessment; Subject Term: PHYSICAL fitness testing; Subject Term: OLDER people -- Physiology; Subject Term: LONGITUDINAL method; Subject Term: DISABILITY evaluation; Subject Term: OLD age; Subject Term: WALKING -- Physiological aspects; Subject Term: AGING -- Physiological aspects; Subject Term: WHITES; Subject Term: PHYSIOLOGY; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guralnik, Jack M.
AU - Kaplan, George A.
T1 - Predictors of Healthy Aging: Prospective Evidence from the Alameda County Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 703
EP - 708
PB - American Public Health Association
SN - 00900036
AB - Abstract: Long-term predictors of high levels of physical functioning were examined in a representative sample of Alameda County, California residents followed from 1965 through 1984. The cohort investigated in this study was born between 1895 and 1919, with survivors being age 65 to 89 at the time of follow-up. A scale of physical functioning w as developed from a comprehensive set of questionnaire items which assessed the full spectrum of physical functioning. Those scoring in the top 20 percent, defined as healthy aging, were compared to the remainder of the cohort, including those who died and those with lower levels of functioning at follow-up. After adjustment for age and functional status at baseline, the following variables were predictive of high functioning at follow-up 19 years later: race (those not Black), higher family income level, absence of hypertension, absence of arthritis, absence of back pain, being a non-smoker, having normal weight, and consuming moderate amounts of alcohol. Sex did not predict high function because of the counterbalancing effects of higher survival in females but greater likelihood of high functioning among surviving males. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GERIATRIC assessment
KW - AGING -- Physiological aspects
KW - OLD age
KW - PHYSICAL fitness testing
KW - OLDER people -- Physiology
KW - COHORT analysis
KW - HEALTH surveys -- United States
KW - AGE groups
KW - PHYSIOLOGICAL aspects
KW - CALIFORNIA
N1 - Accession Number: 4695738; Guralnik, Jack M. 1 Kaplan, George A. 2; Affiliation: 1: National Institute on Aging, California Department of Health Services. 2: Human Population Laboratory, California Department of Health Services.; Source Info: Jun89, Vol. 79 Issue 6, p703; Subject Term: GERIATRIC assessment; Subject Term: AGING -- Physiological aspects; Subject Term: OLD age; Subject Term: PHYSICAL fitness testing; Subject Term: OLDER people -- Physiology; Subject Term: COHORT analysis; Subject Term: HEALTH surveys -- United States; Subject Term: AGE groups; Subject Term: PHYSIOLOGICAL aspects; Subject Term: CALIFORNIA; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Albanes, Demetrius
AU - Blair, Aaron
AU - Taylor, Philip R.
T1 - Cost-Effectiveness of Antibiotic Prophylaxis for Dental Procedures in Patients with Artificial Joints.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 739
EP - 743
PB - American Public Health Association
SN - 00900036
AB - Abstract: We performed a cost-effectiveness analysis to evaluate whether patients with artificial joints should take penicillin, erythromycin, or no antibiotics before dental procedures. We modeled the risk of anaphylaxis from penicillin, the risks and consequences of an artificial joint infection, and the actual variable costs of hospitalization and antibiotics. Penicillin prophylaxis is slightly less expensive than erythromycin prophylaxis but is both more expensive and less effective than no prophylaxis. Erythromycin prophylaxis, the most effective, is the most expensive strategy. The marginal cost effectiveness of erythromycin prophylaxis compared to no prophylaxis is $12,900 per quality-adjusted year of life saved. Sensitivity analysis demonstrates that the risk of developing a joint infection is the key parameter in the analysis. Based on our estimated risk of developing a joint infection, the cost-effectiveness of antibiotic prophylaxis with erythromycin compares favorably with other medical interventions. Thus, until a definitive study to quantify the risk is conducted, patients with artificial joints should take prophylactic erythromycin when they undergo dental procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL prophylaxis
KW - ANTIBIOTICS -- Physiological effect
KW - COST effectiveness
KW - DENTAL hygiene
KW - ARTIFICIAL joints
KW - ORTHOPEDIC implants
KW - ANAPHYLAXIS
KW - ERYTHROMYCIN
KW - PENICILLIN
KW - THERAPEUTIC use
N1 - Accession Number: 4695810; Albanes, Demetrius 1 Blair, Aaron 1 Taylor, Philip R. 2; Affiliation: 1: Center Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Cancer Institute, National Institute of Health, EPN 211, 9000 Rockville Pike, Bethesda, MD 20892. 2: Environmental Epidemiology Branch, Division of Cancer Etiology, NCI, NIH.; Source Info: Jun89, Vol. 79 Issue 6, p739; Subject Term: DENTAL prophylaxis; Subject Term: ANTIBIOTICS -- Physiological effect; Subject Term: COST effectiveness; Subject Term: DENTAL hygiene; Subject Term: ARTIFICIAL joints; Subject Term: ORTHOPEDIC implants; Subject Term: ANAPHYLAXIS; Subject Term: ERYTHROMYCIN; Subject Term: PENICILLIN; Subject Term: THERAPEUTIC use; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Albanes, Demetrius
AU - Blair, Aaron
T1 - Physical Activity and Risk of Cancer in the NHANES I Population.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 744
EP - 750
PB - American Public Health Association
SN - 00900036
AB - Abstract: We studied the relation between self-reported physical activity and cancer in the first National Health and Nutrition Examination Survey (NHANES I) cohort, originally examined between 1971-75, and followed prospectively through the Epidemiologic Follow-up Study (NHEFS), conducted between 1982-84. Among 5,138 men and 7,407 women 25-74 years old, for nonrecreational activity we observed increased risk of cancer among inactive individuals compared to very active persons (for men, relative risk [RR] 1.8, 95% confidence interval [CI] = 1.4, 2.4; for women RR 1.3, 95% CI = 1.0, 1.8). These findings were unchanged after adjustment for cigarette smoking, body mass index (BMI), and other potential confounders. Sites which demonstrated stronger inactivity-cancer associations included colorectum (RR 1.6,95% CI = 0.7, 3.5) and lung (RR 1.6; 95% CI = 1.2, 3.5) among men, and breast (post-menopausal) (RR 1.7; 95% CI = 0.8, 2.9) and cervix (RR 5.2; 95% CI = 1.4, 14.5) among women, although these findings for women were based on relatively few cases. The association between inactivity and cancer was greater among persons of moderate (or lower) BMI, those cases occurring three or more years after baseline, and, in women, those more than 60 years old. In contrast, recreational exercise showed little relation to cancer, with the exception of prostate cancer. The results suggest that inactive individuals are at increased risk of cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER research
KW - HEALTH risk assessment
KW - PHYSICAL fitness testing
KW - ACTIVITIES of daily living
KW - HEALTH surveys
KW - EVALUATION
KW - CANCER prevention
KW - BODY mass index
KW - CANCER in women
KW - PREVENTIVE medicine
N1 - Accession Number: 4695821; Albanes, Demetrius 1 Blair, Aaron 1; Affiliation: 1: Center Prevention Studies Branch, Division of Cancer Prevention and Control, National Cancer Institute, National Cancer Institute, National Institute of Health, EPN 211, 9000 Rockville Pike, Bethesda, MD 20892.; Source Info: Jun89, Vol. 79 Issue 6, p744; Subject Term: CANCER research; Subject Term: HEALTH risk assessment; Subject Term: PHYSICAL fitness testing; Subject Term: ACTIVITIES of daily living; Subject Term: HEALTH surveys; Subject Term: EVALUATION; Subject Term: CANCER prevention; Subject Term: BODY mass index; Subject Term: CANCER in women; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liu, Ingrid Y.
AU - White, Lon
AU - LaCroix, Andrea Z.
T1 - The Association of Age-Related Macular Degeneration and Lens Opacities in the Aged.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 765
EP - 769
PB - American Public Health Association
SN - 00900036
AB - Abstract: Data from 3,087 persons age 45 or older in the National Health and Nutrition Survey, 1971-74, showed that subjects with lens opacifying disease had an increased odds for age-related macular degeneraton (AMD) compared to those who had no lens opacities. The crude odds ratio for aphakic patients was 4.6 (95% CI = 2.5, 8.6). The association remained after controlling for age, sex, and systolic blood pressure (a common risk factor) in a logistic regression model. These data are consistent with the hypothesis that light-reduced damage may contribute to both lens and retinal disease and suggest that cataract extraction without implantation of ultra-violet/blue light absorbing intraocular lens may place subjects at increased risk of AMD. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETINAL degeneration
KW - OLDER people -- Diseases
KW - RETINAL diseases
KW - AGING -- Physiological aspects
KW - DEGENERATION (Pathology)
KW - OPACITY (Optics)
KW - VISION disorders in old age
KW - OLD age
KW - GERIATRIC ophthalmology
KW - PHYSIOLOGICAL aspects
N1 - Accession Number: 4695856; Liu, Ingrid Y. 1 White, Lon 1 LaCroix, Andrea Z. 1; Affiliation: 1: Epidemiology, Demography, and Biometry Program, National Institute on Aging.; Source Info: Jun89, Vol. 79 Issue 6, p765; Subject Term: RETINAL degeneration; Subject Term: OLDER people -- Diseases; Subject Term: RETINAL diseases; Subject Term: AGING -- Physiological aspects; Subject Term: DEGENERATION (Pathology); Subject Term: OPACITY (Optics); Subject Term: VISION disorders in old age; Subject Term: OLD age; Subject Term: GERIATRIC ophthalmology; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perez-Stabel, Eliseo J.
AU - McMillen, Marilyn Miles
AU - Harris, Maureen I.
AU - Juarez, Ramaldo Z.
AU - Knowler, William C.
AU - Stern, Michael P.
AU - Haynes, Suzanne G.
T1 - Self-Reported Diabetes in Mexican Americans: HHANES 1982-84.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 770
EP - 772
PB - American Public Health Association
SN - 00900036
AB - Abstract: In the Hispanic Health and Nutrition Examination Survey (HHANES) of 3,928 Mexican Americans ages 20-74 years, the age-adjusted prevalence of self-reported diabetes was 6.8 percent among men and 7.6 percent among women. Comparable age-adjusted rates for the US population in a national survey were 2.9 percent in men and 3.8 percent in women. The prevalence of diabetes in Mexican Americans is greater in older age groups, was similar in men and women, and among women only was inversely associated with education. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SELF-evaluation
KW - DIABETES
KW - MEXICAN Americans -- Health
KW - DIABETES in old age
KW - OLDER people -- Diseases
KW - HEALTH education of women
KW - HEALTH surveys
KW - AGE distribution (Demography)
KW - POPULATION aging
N1 - Accession Number: 4695860; Perez-Stabel, Eliseo J. 1 McMillen, Marilyn Miles 2 Harris, Maureen I. 3 Juarez, Ramaldo Z. 4 Knowler, William C. 5 Stern, Michael P. 6 Haynes, Suzanne G. 2; Affiliation: 1: Division of General Internal Medicine, Department of Medicine, University of California 2: Medical Statistics branch of National Center for Health Statistics 3: National Diabetes Data Group. National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Washington 4: Pan American University, Edinburg, Texas 5: NIDDKD/NIH in Phoenix, Arizona 6: University of Texas Health Science Center, San Antonio; Source Info: Jun89, Vol. 79 Issue 6, p770; Subject Term: SELF-evaluation; Subject Term: DIABETES; Subject Term: MEXICAN Americans -- Health; Subject Term: DIABETES in old age; Subject Term: OLDER people -- Diseases; Subject Term: HEALTH education of women; Subject Term: HEALTH surveys; Subject Term: AGE distribution (Demography); Subject Term: POPULATION aging; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mayer, William J.
AU - McWhorter, William P.
T1 - Black/White Differences in Non-treatment of Bladder Cancer Patients and Implications for Survival.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/06//
VL - 79
IS - 6
M3 - Article
SP - 772
EP - 775
PB - American Public Health Association
SN - 00900036
AB - Abstract: Analysis of 20,764 White and 882 Black bladder cancer patients diagnosed during 1978-85 indicates that Black patients were more likely than White patients to go untreated following diagnosis after adjustment for age- and stage-at-diagnosis, sex, and tumor histology (OR = 1.80, 95% CI = 1.33, 2.43). Treatment status was found to be a significant predictor of five-year survival after adjustment (treated/untreated odds ratio = 3.16, 95% CI = 2.08, 4.79). Results suggest that differences in initial therapy may contribute to the survival differential between Black and White bladder cancer patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLADDER cancer
KW - WHITES
KW - HEALTH
KW - BLACKS -- Health
KW - CANCER -- Mortality
KW - CANCER patients
KW - CANCER treatment
KW - THERAPEUTICS
KW - CLINICAL medicine
KW - SOCIAL aspects
N1 - Accession Number: 4695865; Mayer, William J. 1 McWhorter, William P. 1; Affiliation: 1: Division of Cancer Prevention and Control, National Cancer Institute; Source Info: Jun89, Vol. 79 Issue 6, p772; Subject Term: BLADDER cancer; Subject Term: WHITES; Subject Term: HEALTH; Subject Term: BLACKS -- Health; Subject Term: CANCER -- Mortality; Subject Term: CANCER patients; Subject Term: CANCER treatment; Subject Term: THERAPEUTICS; Subject Term: CLINICAL medicine; Subject Term: SOCIAL aspects; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Filley, E.
AU - Andreoli, A.
AU - Steele, J.
AU - Waters, M.
AU - Wagner, D.
AU - Nelson, D.
AU - Tung, K.
AU - Rademacher, T.
AU - Dwek, R.
AU - Rook, G. A. W.
T1 - A transient rise in agalactosyl IgG correlating with free interleukin 2 receptors, during episodes of erythema nodosum leprosum.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/06//
VL - 76
IS - 3
M3 - Article
SP - 343
EP - 347
PB - Wiley-Blackwell
SN - 00099104
AB - The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosaminc and not galaclose (%GO) has previously been shown to be raised in rheumatoid arthritis (RA), Crohn's disease (CD) and tuberculosis (Tb), but to be normal in sarcoidosis (SA). and in both lepromatous and tuberculoid leprosy. However we have now studied %GO in sequential serum samples collected from lepromatous leprosy patients undergoing episodes of erythema nodosum leprosum (ENL). During ENL %GO is transiently raised, and this rise parallels an increase in circulating interleukin 2 receptors (IL-2R). These findings confirm that changes in T cell function occur during ENL. Moreover it appears that %GO rises when there is, simultaneously, T-cell-mediated tissue damage and an acute phase response (RA, CD, Tb, ENL), but not when there is an acute phase response without major T cell involvement, or chronic T cell activity alone (SA, and tuberculoid leprosy). We suggest therefore that %GO is an indicator of a type of T cell activity with broad immunopathological implications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHEUMATOID arthritis
KW - OLIGOSACCHARIDES
KW - GLUCOSIDES
KW - GLYCOASPARAGINASE
KW - TUBERCULOSIS
KW - T cells
KW - LEPROSY
KW - SERUM
KW - agalactosyl IgG
KW - erythema nodosum leprosum
KW - interleukin 2 receptor
KW - leprosy
KW - tuberculosis
N1 - Accession Number: 16002989; Filley, E. 1 Andreoli, A. 1 Steele, J. 1 Waters, M. 1 Wagner, D. 2 Nelson, D. 2 Tung, K. 3 Rademacher, T. 4 Dwek, R. 4 Rook, G. A. W. 1; Affiliation: 1: Department of Medical Microbiology, University College and Middlesex School of Medicine, London. 2: Immunophysiology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda. 3: Washington University, School of Medicine, Departments of Pathology and Medicine, St. Louis. 4: Glycobiology Unit, Department of Biochemistry, Oxford.; Source Info: Jun1989, Vol. 76 Issue 3, p343; Subject Term: RHEUMATOID arthritis; Subject Term: OLIGOSACCHARIDES; Subject Term: GLUCOSIDES; Subject Term: GLYCOASPARAGINASE; Subject Term: TUBERCULOSIS; Subject Term: T cells; Subject Term: LEPROSY; Subject Term: SERUM; Author-Supplied Keyword: agalactosyl IgG; Author-Supplied Keyword: erythema nodosum leprosum; Author-Supplied Keyword: interleukin 2 receptor; Author-Supplied Keyword: leprosy; Author-Supplied Keyword: tuberculosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Good, M. F.
AU - Powell, L. W.
AU - Halliday, J. W.
T1 - IL-2 and IL-4 can co-modulate the generation of cytotoxic T cells through CD8- CD4- splenic lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1989/06//
VL - 67
IS - 2
M3 - Article
SP - 225
EP - 230
PB - Wiley-Blackwell
SN - 00192805
AB - Following activation with concanavalin A (Con A), murine T cells are able to suppress the generation of allospecific cytotoxic T lymphocytes (CTL). We have analysed the phenotype, tissue distribution, and mode of action of these cells in an effort to understand further the regulation of CTL-mediated immunity. The precursors of such cells are rare (1 cell per 70,000 spleen cells being able to suppress the generation of a particular allospecific response), but are much more abundant in the spleen than in the thymus. By the use of cytotoxic antibodies, we have been able to demonstrate that the splenic precursors of such cells are Thy-1.2+, CD4-, CD8- but, following activation with Con A, these cells acquire the CD8 marker. Cellular suppression by these lymphocytes is dramatically increased in the presence of the Th2-derived lymphokine, IL-4, whereas IL-2, the Th1-derived lymphokine. significantly augments the generation of CTL in a mixed lymphocyte culture even though relative suppression is still evident in the presence of Con A-activated lymphocytes. Suppression is not due to overcrowding of a cell culture since adding Con A-activated cells to an A anti-B + C culture often resulted in the suppression of the A anti-B response but not the A anti-C response, or vice versa. Suppression appears to require cellular interaction since supernatants from Con A-activated lymphocytes are unable to mediate suppression. Such cells may play an important intermediate role in homeostasis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-2
KW - INTERLEUKIN-4
KW - CD antigens
KW - T cells
KW - INTERLEUKINS
KW - LYMPHOKINES
KW - CELL surface antigens
KW - FC receptors
N1 - Accession Number: 13358949; Good, M. F. 1,2 Powell, L. W. 2 Halliday, J. W. 2; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. 2: Department of Medicine, University of Queensland, Brisbane, Australia; Source Info: Jun89, Vol. 67 Issue 2, p225; Subject Term: INTERLEUKIN-2; Subject Term: INTERLEUKIN-4; Subject Term: CD antigens; Subject Term: T cells; Subject Term: INTERLEUKINS; Subject Term: LYMPHOKINES; Subject Term: CELL surface antigens; Subject Term: FC receptors; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Milo, George E.
AU - Yohn, Joseph
AU - Schuller, David
AU - Noyes, Inge
AU - Lehman, Teresa
T1 - Comparative Stages of Expression of Human Squamous Carcinoma Cells and Carcinogen Transformed Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/06//
VL - 92
IS - 6
M3 - Article
SP - 848
EP - 853
SN - 0022202X
AB - The mouse monoclonal antibody OSU 22-3 was prepared using cells from a squamous cell carcinoma (SCC) as an immunogen. This antibody reacts with an antigen found on squamous cell carcinomas but does not react with normal keratinocytes. This antibody and two antibodies that react with normal keratinocytes were used as markers of malignant and normal phenotypes. These markers were used to evaluate several spontaneous and carcinogen initiated SCC tumors and to identify the expression of an antigen associated with a malignant phenotype. A variety of subpopulations in carcinogen initiated tumors and spontaneous SCC tumors were noted. The subpopulations that reacted only with MoAb OSU 22-3 exhibited features of anchorage independent growth and cellular invasiveness, and formed progressively growing tumors in nude mice. Other SCC spontaneous tumor cell subpopulations reacted with the antibodies associated with normal keratinocytes. These cells did not proliferate in vitro and did not form tumors in the nude mouse. There were other carcinogen transformed cells which reacted with MoAb OSU 22-3 but not with the antibodies associated with normal keratinocytes. These cells exhibited anchorage independent growth and cellular invasiveness but did not form tumors in nude mice. We conclude from this work that human SCC tumors contain multiple cell populations. These cell populations have varied growth properties and express surface antigens that may indicate their malignant vigor. Carcinogen transformed keratinocytes do exhibit some of the characteristics of SCC tumor phenotypes but not the property of malignant progressively growing cells on a routine and consistent basis. This feature is transiently and inconsistently expressed in a surrogate host by populations prepared from spontaneous SSC tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SQUAMOUS cell carcinoma
KW - CARCINOGENS
KW - KERATINOCYTES
KW - MONOCLONAL antibodies
KW - IMMUNOGENETICS
KW - PHENOTYPE
N1 - Accession Number: 12696872; Milo, George E. 1 Yohn, Joseph Schuller, David 2 Noyes, Inge 1 Lehman, Teresa 3; Affiliation: 1: Departments of Physiological Chemistry and the Comprehensive Cancer Center. 2: Department of Otolaryngology, The Ohio State Urüvenitv, Columbus, Ohio. 3: Laboratory of Human Carcinogenesis, National Institutes of Health, Bethesda. Maryland, U.S.A.; Source Info: Jun89, Vol. 92 Issue 6, p848; Subject Term: SQUAMOUS cell carcinoma; Subject Term: CARCINOGENS; Subject Term: KERATINOCYTES; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGENETICS; Subject Term: PHENOTYPE; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12696872
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Clerici, Mario
AU - Stocks, Naomi I.
AU - Zajac, Robert A.
AU - Boswell, R. Neal
AU - Bernstein, Denise C.
AU - Mann, Dean L.
AU - Shearer, Gene M.
AU - Berzofsky, Jay A.
T1 - Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals.
JO - Nature
JF - Nature
Y1 - 1989/06//6/1/1989
VL - 339
IS - 6223
M3 - Letter
SP - 383
EP - 385
SN - 00280836
AB - T lymphocytes from mice¹ and healthy humans² immunized against the human immunodeficiency virus (HIV) envelope have recently been shown to recognize two antigenic regions of the gp160 HIV-envelope protein which have been located on the basis of amphipathicity3-6. In HIV-infected humans, T-cell proliferative responses are lost soon after infection7,8. Here we demonstrate that interleukin-2 production is often retained even when proliferative activity is absent, and that it can be used to monitor T-helper cell responses by HIV-seropositive donors. We use this approach to investigate the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gpl60 peptides and to influenza A virus, an antigen requiring intact CD4 T-helper cell function. As many as 67% of the HIV-seropositive donors who retain responsiveness to influenza A virus respond to a single peptide, and 85-90% responded to at least one of the peptides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - Letters to the editor
KW - Peptides
KW - Influenza A virus
KW - T cells
KW - HIV-positive persons
KW - Interleukin-2
N1 - Accession Number: 22830551; Clerici, Mario 1; Stocks, Naomi I. 1; Zajac, Robert A. 2; Boswell, R. Neal 2; Bernstein, Denise C. 1; Mann, Dean L. 3; Shearer, Gene M. 1; Berzofsky, Jay A. 4; Affiliations: 1: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; 2: HIV Unit/SGHMMM, Wilford Hall, Lackland AFB, Texas 28236, USA; 3: Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; 4: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892, USA; Issue Info: 6/1/1989, Vol. 339 Issue 6223, p383; Thesaurus Term: HIV (Viruses); Subject Term: Letters to the editor; Subject Term: Peptides; Subject Term: Influenza A virus; Subject Term: T cells; Subject Term: HIV-positive persons; Subject Term: Interleukin-2; Number of Pages: 3p; Illustrations: 3 Charts, 3 Graphs; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Chaudhary, Vijay K.
AU - Queen, Cary
AU - Junghans, Richard P.
AU - Waldmann, Thomas A.
AU - FitzGerald, David J.
AU - Pastan, Ira
T1 - A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.
JO - Nature
JF - Nature
Y1 - 1989/06//6/1/1989
VL - 339
IS - 6223
M3 - Letter
SP - 394
EP - 397
SN - 00280836
AB - Antibodies and growth factors have been chemically coupled to different toxins to produce cytotoxic molecules that selectively kill cells bearing appropriate antigens or receptors1,2. Antibody-toxin conjugates (immunotoxins) produced using conventional chemical coupling techniques have several undesirable characteristics. The smallest binding unit of an antibody is an Fv fragment which consists of a light and heavy chain variable domain. Recently, active single chain Fv fragments of antibodies have been produced in Esherichia coli by attaching the light and heavy chain variable domains together with a peptide linker3,4. Here we describe the construction and expression in E. coli of a single chain antibody toxin fusion protein, anti-Tac(Fv)-PE40, in which the variable regions of anti-Tac, a monoclonal antibody to the p55 subunit of the human interleukin-2 receptor5, arc joined in peptide linkage to PE40, a modified form of Pseudomonas exotoxin lacking its binding domain. Anti-Tac(Fv)-PE40 was very cytotoxic to two interleukin-2 receptor-bearing human cell lines but was not cytotoxic to receptor-negative cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Letters to the editor
KW - Interleukin-2
KW - Pseudomonas
KW - Cell lines
KW - Monoclonal antibodies
KW - Growth factors
KW - Antibody-toxin conjugates
N1 - Accession Number: 22830581; Chaudhary, Vijay K. 1; Queen, Cary 2; Junghans, Richard P. 3; Waldmann, Thomas A. 3; FitzGerald, David J. 1; Pastan, Ira 1; Affiliations: 1: Laboratory of Molecular Biology, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; 2: Protein Design Labs, 3181 Porter Drive, Palo Alto, California 94304, USA; 3: Metabolism Branch, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Issue Info: 6/1/1989, Vol. 339 Issue 6223, p394; Thesaurus Term: Escherichia coli; Subject Term: Letters to the editor; Subject Term: Interleukin-2; Subject Term: Pseudomonas; Subject Term: Cell lines; Subject Term: Monoclonal antibodies; Subject Term: Growth factors; Subject Term: Antibody-toxin conjugates; Number of Pages: 4p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06621-012
AN - 2006-06621-012
AU - Lamb, Michael E.
T1 - Fathers' Role or Father's Roles?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1989/06//
VL - 34
IS - 6
SP - 551
EP - 551
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06621-012. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Lamb, Michael E.; Section on Social and Emotional Development, National Institute of Child Health and Human Development, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family; Father Child Relations; Fathers; Parental Role; Parenting Skills. Classification: Childrearing & Child Care (2956). Population: Human (10). Reviewed Item: Bronstein, Phyllis (Ed); Cowan, Carolyn Pape (Ed). Fatherhood Today: Men's Changing Role in the Family=New York: Wiley, 1988. 364 pp. $39.95; 1988. Page Count: 1. Issue Publication Date: Jun, 1989.
AB - Reviews the book, Fatherhood Today: Men's Changing Role in the Family edited by Phyllis Bronstein and Carolyn Pape Cowan (1988). Of the 19 chapters, 7 are organized into a section concerned with fathers and father-child relationships in two-parent families. Only one provides an account of descriptive research on father-infant relationships (Yogman, Cooley, and Kindlon) and another of paternal effects on children (Bronstein)--the two 'traditional' foci for research on fathers. Two other chapters cover the increasingly insightful work on the motivation for and psychological appraisals of fatherhood by fathers (P. Cowan; Daniels and Weingarten), while another deals with the correlates and possible antecedents of variations in paternal involvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - paternal involvement
KW - father-infant relationships
KW - paternal effects
KW - fathers role
KW - 1989
KW - Family
KW - Father Child Relations
KW - Fathers
KW - Parental Role
KW - Parenting Skills
KW - 1989
U2 - Bronstein, Phyllis (Ed); Cowan, Carolyn Pape (Ed). (1988); Fatherhood Today: Men's Changing Role in the Family; New York: Wiley, 1988. 364 pp. $39.95; 0-471-83627-3.
DO - 10.1037/031146
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Proton Radiation Therapy Effective.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/09/
VL - 261
IS - 22
M3 - Article
SP - 3214
EP - 3214
SN - 00987484
AB - Reports on the effectiveness of proton radiation therapy in the treatment of chordoma or low-grade chondrosarcoma of the base of the skull. Local control rate and actuarial local control rate in patients receiving the therapy.
KW - RADIATION
KW - PROTONS
KW - CHORDOMA
KW - SARCOMA
KW - SKULL -- Diseases
N1 - Accession Number: 10982500; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: RADIATION; Subject Term: PROTONS; Subject Term: CHORDOMA; Subject Term: SARCOMA; Subject Term: SKULL -- Diseases; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Effects of Perinatal Exposure to PCBs.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/09/
VL - 261
IS - 22
M3 - Article
SP - 3214
EP - 3214
SN - 00987484
AB - Studies the effects of perinatal exposure to polychlorinated biphenyls (PCBs). Relationship found between transplacental exposure to PCBs and lower psychomotor scores in the first year of life.
KW - POLYCHLORINATED biphenyls
KW - BIPHENYL compounds
N1 - Accession Number: 10982501; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: POLYCHLORINATED biphenyls; Subject Term: BIPHENYL compounds; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - New Insights into Pathogenesis of Hepatic Encephalopathy.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/09/
VL - 261
IS - 22
M3 - Article
SP - 3214
EP - 3214
SN - 00987484
AB - Investigates the role of gamma-aminobutyric acid-benzodiazepine (BZDZ) receptor complex in the pathogenesis of hepatic encephalopathy. Use of animal models to show that elevated levels of a compound exhibiting BZDZ receptor agonist properties are associated with hepatic encephalopathy.
KW - GABA
KW - BENZODIAZEPINES
KW - HEPATIC encephalopathy
N1 - Accession Number: 10982502; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: GABA; Subject Term: BENZODIAZEPINES; Subject Term: HEPATIC encephalopathy; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Study of Cardiovascular Risk Factors in Older Adults.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/09/
VL - 261
IS - 22
M3 - Article
SP - 3214
EP - 3214
SN - 00987484
AB - Announces that start of a multicenter epidemiological study to determine cardiovascular risk factors in older adults.
KW - CARDIOVASCULAR diseases -- Risk factors
KW - HEART diseases -- Risk factors
N1 - Accession Number: 10982503; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 6/9/89, Vol. 261 Issue 22, p3214; Subject Term: CARDIOVASCULAR diseases -- Risk factors; Subject Term: HEART diseases -- Risk factors; Number of Pages: 1/9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schatzkin, Arthur
AU - Greenwald, Peter
AU - Byar, David P.
AU - Clifford, Carolyn K.
T1 - The Dietary Fat-Breast Cancer Hypothesis is Alive.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/09/
VL - 261
IS - 22
M3 - Article
SP - 3284
EP - 3287
SN - 00987484
AB - Discusses the need for studies to examine the dietary fat-breast cancer hypothesis. Laboratory investigations in humans that examine possible mechanisms for the effects of fat; Large, prospective epidemiologic studies; Randomized, controlled diet trials.
KW - FAT
KW - BREAST cancer
N1 - Accession Number: 10982511; Schatzkin, Arthur 1 Greenwald, Peter 1 Byar, David P. 1 Clifford, Carolyn K. 1; Affiliation: 1: Division of Cancer Prevention and Control National Cancer Institute; Source Info: 6/9/89, Vol. 261 Issue 22, p3284; Subject Term: FAT; Subject Term: BREAST cancer; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goddard, Colin
AU - Aquino, Angelo
AU - Glazer, Robert I.
AU - Felsted, Ronad L.
T1 - Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/06/15/
VL - 182
IS - 2
M3 - Article
SP - 323
EP - 326
PB - Wiley-Blackwell
SN - 00142956
AB - The N-terminal p17gag protein of the human immunodeficiency virus has been shown to incorporate radioactivity following labelling of infected cell lines with [³H]myristic acid. We investigated p17gag to determine whether the incorporated radioactivity was the consequence of N-terminal myristoylation. The virus was purified by density gradient centrifugation after labelling chronically infected H9 cells with [³H]myristic acid. The p17gag was isolated by immunoprecipitation and subjected to partial acid hydrolysis. [³H]Myristoylglycine generated by the hydrolysis was derivatized to 4-(p-nitrobenzylidene)-2-tridecanoyloxazol-5-one and identified against a co-eluting, derivatized, unlabelled N-myristoylglycine standard by reverse-phase high-performance liquid chromatography. This study unequivocally demonstrates that p17gag is an N-myristoylated protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - PROTEINS
KW - CELL lines
KW - HYDROLYSIS
KW - LIQUID chromatography
KW - BIOCHEMISTRY
N1 - Accession Number: 13793513; Goddard, Colin 1 Aquino, Angelo 1 Glazer, Robert I. 1 Felsted, Ronad L. 1; Affiliation: 1: Laboratory of Biological Chemistry, Division of Cancer Treatment, Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda; Source Info: 6/15/89, Vol. 182 Issue 2, p323; Subject Term: HIV (Viruses); Subject Term: PROTEINS; Subject Term: CELL lines; Subject Term: HYDROLYSIS; Subject Term: LIQUID chromatography; Subject Term: BIOCHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaslow, Richard A.
AU - Blackwelder, William C.
AU - Ostrow, David G.
AU - Yerg, Diane
AU - Palenicek, John
AU - Coulson, Anne H.
AU - Valdiserri, Ronald O.
T1 - No Evidence for a Role of Alcohol or Other Psychoactive Drugs in Accelerating Immunodeficiency in HIV-1-Positive Individuals.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/06/16/
VL - 261
IS - 23
M3 - Article
SP - 3424
EP - 3429
SN - 00987484
AB - Describes the lack of evidence for a relationship between use of psychoactive drugs or alcohol and subsequent occurrence of AIDS or other manifestations of clinical and cellular immunodeficiency. No manifestations of immunodeficiency positively associated with substance use; Inability of psychoactive drugs to enhance the progression of human immunodeficiency virus infection.
KW - PSYCHIATRIC drugs
KW - ALCOHOL
KW - AIDS (Disease)
KW - IMMUNODEFICIENCY
N1 - Accession Number: 10982641; Kaslow, Richard A. 1 Blackwelder, William C. 1 Ostrow, David G. 2,3 Yerg, Diane 1 Palenicek, John 4 Coulson, Anne H. 5 Valdiserri, Ronald O. 6; Affiliation: 1: National Institute of Allergy and Infectious Diseases, National Institutes of Health 2: Howard Brown Memorial Clinic and Northwestern University 3: Department of Psychiatry and Institute for Social Research, University of Michigan 4: The Johns Hopkins University School of Hygiene and Public Health 5: University of California School of Public Health and Medicine 6: University of Pittsburgh (Pa) Graduate School of Public Health; Source Info: 6/16/89, Vol. 261 Issue 23, p3424; Subject Term: PSYCHIATRIC drugs; Subject Term: ALCOHOL; Subject Term: AIDS (Disease); Subject Term: IMMUNODEFICIENCY; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lal, R. B.
AU - Kumaraswami, V.
AU - Krishnan, N.
AU - Nutman, T. B.
AU - Ottesen, E. A.
T1 - Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/07//
VL - 77
IS - 1
M3 - Article
SP - 77
EP - 82
PB - Wiley-Blackwell
SN - 00099104
AB - To examine the relationship between lymphocyte phenotypes and stales or activation in patients with Bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n= 15), and on patients with cither asymptomatic microfilaraemia (MF; n = 12) or elephantiasis (CP: n =11). In contrast to findings by others in a population with Brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found lo be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion (P < 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 ± 8.6%) than in the MF (8.9 ± 2.6%) or NV (8.3 ± 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen induced proliferation was seen ( r = -0.54; P < 0.001). These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-2
KW - CELL populations
KW - LYMPHOCYTES
KW - FILARIASIS
KW - HELMINTHIASIS
KW - PHENOTYPE
KW - CELL culture
KW - CD8 lymphocytes
KW - Lymphatic filariasis
KW - lymphocyte phenotype
N1 - Accession Number: 16137232; Lal, R. B. 1 Kumaraswami, V. 2 Krishnan, N. 2 Nutman, T. B. 1 Ottesen, E. A. 1; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. 2: Tuberculosis Research Center, Madras, India.; Source Info: Jul1989, Vol. 77 Issue 1, p77; Subject Term: INTERLEUKIN-2; Subject Term: CELL populations; Subject Term: LYMPHOCYTES; Subject Term: FILARIASIS; Subject Term: HELMINTHIASIS; Subject Term: PHENOTYPE; Subject Term: CELL culture; Author-Supplied Keyword: CD8 lymphocytes; Author-Supplied Keyword: Lymphatic filariasis; Author-Supplied Keyword: lymphocyte phenotype; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hirose, S.
AU - Singh, V. K.
AU - Donoso, L. A.
AU - Shinohara, T.
AU - Kotake, S.
AU - Tanaka, T.
AU - Kuwabara, T.
AU - Yamaki, K.
AU - Gery, I.
AU - Nussenblatt, R. B.
T1 - An 18-mer peptide derived from the retinal S antigen induces uveitis and pinealitis in primates.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/07//
VL - 77
IS - 1
M3 - Article
SP - 106
EP - 111
PB - Wiley-Blackwell
SN - 00099104
AB - S-antigen, a photoreceptor cell protein, induces a predominantly T-cell mediated autoimmune uveitis in many vertebrate animals, including primates. Because of this activity and the finding of immune responses to S antigen in patients with uveilis, this protein has been implicated In the pathogenesis of uveitis in humans, Peptide M, an 18-amino acid component of S antigen, has previously been shown to be highly uveito pathogenic in rats and guinea pigs. We report here that peptide M is immunopathogenic in some monkeys, producing inflammatory changes in eyes and pineal glands similar to those induced by native S antigen. Monkeys with disease also developed intense immune responses to peptide M, measured by the lymphocyte proliferation assay. In addition, lymphocytes from these monkeys reacted against whole S antigen. Furthermore, lymphocytes from certain monkeys immunized with whole S antigen responded well against peptide M, thus indicating that this peptide is an immunodominant epitope in these animals. Two of the four monkeys immunized with peptide M did not develop disease. Lymphocytes from these two animals did not respond In culture against the peptide. Following immunization with the whole protein, these monkeys were capable. however, of developing cellular immunity against S antigen and one of them developed disease. The possible involvement of peptide M in the pathogenesis of uveitis in humans is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UVEITIS
KW - EYE -- Inflammation
KW - PEPTIDES
KW - AMINO acids
KW - INFLAMMATION -- Mediators
KW - PINEAL gland
KW - IMMUNE response -- Molecular aspects
KW - lymphocyte proliferation
KW - pinealitis
KW - primates
KW - S antigen
KW - uveitis
N1 - Accession Number: 16137239; Hirose, S. 1 Singh, V. K. 1 Donoso, L. A. 2 Shinohara, T. 1 Kotake, S. 1 Tanaka, T. 1 Kuwabara, T. 3 Yamaki, K. 1 Gery, I. 1 Nussenblatt, R. B. 1; Affiliation: 1: Laboratories of Immunology, National Institutes of Health, Bethesda, MD. 2: Wills Eye Hospital, Philadelphia, PA. 3: Ophthalmic Pathology, National Eye Institute, National Institutes of Health, Bethesda, MD.; Source Info: Jul1989, Vol. 77 Issue 1, p106; Subject Term: UVEITIS; Subject Term: EYE -- Inflammation; Subject Term: PEPTIDES; Subject Term: AMINO acids; Subject Term: INFLAMMATION -- Mediators; Subject Term: PINEAL gland; Subject Term: IMMUNE response -- Molecular aspects; Author-Supplied Keyword: lymphocyte proliferation; Author-Supplied Keyword: pinealitis; Author-Supplied Keyword: primates; Author-Supplied Keyword: S antigen; Author-Supplied Keyword: uveitis; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van den Hoogen, Yvonne Th.
AU - Hilgersom, Coen M.A.
AU - Brozda, Danuta
AU - Lesiak, Krystyna
AU - Torrence, Paul F.
AU - Altona, Cornelis
T1 - Conformational analysis of brominated pA2'-5'A2'-5'A analogs.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/07//7/1/89
VL - 182
IS - 3
M3 - Article
SP - 629
EP - 637
PB - Wiley-Blackwell
SN - 00142956
AB - NMR and model-building studies were carried out on pA2'-5'A2'-5'A and analogs in which one or more of the A residues were replaced by 8-bromoadenosine. Chemical shifts, coupling constants and NOE data were used to obtain structural information. The N/S equilibrium constant of the ribose rings as well as the phase angles and puckering amplitudes were determined from the experimental coupling constants with the aid of an improved version of the PSEUROT program. Chemical shifts in combination with NOE data were used to monitor base-base interactions and the orientation of the bases (syn or anti). The combined data suggest that different types of stacking interactions are present in the various compounds. Bromination of the first or second residue in the trimers results in a preference for N-type sugar and syn orientation of the base in these residues. When A(3) is brominated, an S-type sugar conformation together with a syn orientation of the base is favoured at the 2' terminus. Energy-minimized models of the different stacking interactions are presented which fit the present collection of data. The possible correlation between biological activity of these compounds and their conformation is briefly discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE
KW - NUCLEAR magnetic resonance
KW - RIBOSE
KW - EQUILIBRIUM
KW - BROMINATION
KW - BIOCHEMISTRY
N1 - Accession Number: 13923309; van den Hoogen, Yvonne Th. 1 Hilgersom, Coen M.A. 1 Brozda, Danuta 2 Lesiak, Krystyna 2 Torrence, Paul F. 2 Altona, Cornelis 1; Affiliation: 1: Gorlaeus Laboratories, Leiden University 2: Section on Biomedical Chemistry, Laboratory of Analytical Chemistry, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD; Source Info: 7/1/89, Vol. 182 Issue 3, p629; Subject Term: ADENOSINE; Subject Term: NUCLEAR magnetic resonance; Subject Term: RIBOSE; Subject Term: EQUILIBRIUM; Subject Term: BROMINATION; Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khan, Wasiuddin A.
AU - Park, Sang S.
AU - Gelboin, Harry V.
AU - Bickers, David R.
AU - Mukhtar, Hasan
T1 - Monoclonal Antibodies Directed Characterization of Epidermal and Hepatic Cytochrome P-450 Isozymes Induced by Skin Application of Therapeutic Crude Coal Tar.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/07//
VL - 93
IS - 1
M3 - Article
SP - 40
EP - 45
SN - 0022202X
AB - A single application of crude coal tar (CCT) solution (USP) to the skin of neonatal rats was shown to induce epidermal and hepatic cytochrome P-450(P-450)-dependent monooxygenase activities. To further characterize the induction response, in this study we have utilized highly specific monoclonal antibodies (MoAb) 1-7-1, 2-66-3, and 1-98-1 directed against highly purified rat liver P-450s induced by 3-methylcholanthrene, phenobarbital and ethanol, respectively. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of hepatic microsomes prepared from CCT-treated animals showed a significant increase in the commassie blue stainable proteins in the P-450 region; however, this was not evident in epidermal microsomes. Immunoblot analysis of epidermal and hepatic microsomes with MoAb 1-7-1 revealed strong immunoprecipitin brands in both tissues. MoAb 2-66-3 showed significant immunoreactivity only with hepatic microsomes. Interestingly, CCT treatment resulted in suppression of immunoreactivity with MoAb 1-98-1 in hepatic microsomes. MoAb 1-7-1 and 2-66-3 exhibited concentration-dependent inhibitory effects in aryl hydrocarbon hydroxylase and 7-ethoxycoumarin-O-deethylase activities induced by CCT application. MoAb 1-7-1 was substantially more effective in this respect. Epidermal and hepatic mocrosomes prepared from CCT-treated rats showed significantly greater metabolism of benzo(a)pyrene (BP). MoAb 1-7-1 and MoAb 2-66-3 inhibited BP metabolism in both the tissues. However, MoAb 1-7-1 was more inhibitory in this regard as compared to MoAb2-66-3. These studies indicate that topical application of therapeutic CCT to the skin of neonatal rats results in induction of P-450 isozyme c in epidermis and isozymes b and c in liver, and that this induction is associated with the suppression of P-450 isozyme J in liver. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - CYTOCHROMES
KW - EPIDERMIS
KW - OXYGENASES
KW - ISOENZYMES
KW - GEL electrophoresis
N1 - Accession Number: 12277342; Khan, Wasiuddin A. 1 Park, Sang S. 2 Gelboin, Harry V. 2 Bickers, David R. 1 Mukhtar, Hasan 1; Affiliation: 1: Department of Dermatology, University Hospital of Cleveland, Case Western Reserve University and Veterans Administration Medical Center, Cleveland, Ohio 2: Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Jul89, Vol. 93 Issue 1, p40; Subject Term: MONOCLONAL antibodies; Subject Term: CYTOCHROMES; Subject Term: EPIDERMIS; Subject Term: OXYGENASES; Subject Term: ISOENZYMES; Subject Term: GEL electrophoresis; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277342
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jetten, Anton M.
AU - George, Margaret A.
AU - Pettit, George R.
AU - Herald, Cherry L.
AU - Rearick, James I.
T1 - Action of Phorbol Esters, Bryostatins, and Retinoic Acid on Cholesterol Sulfate Synthesis: Relation to the Multistep Process of Differentiation in Human Epidermal Keratinocytes.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/07//
VL - 93
IS - 1
M3 - Article
SP - 108
EP - 115
SN - 0022202X
AB - This study examines the action of phorbol 12-myristate 13-acetate (PMA) on the synthesis of cholesterol sulfate in cultured normal and transformed human epidermal keratinocytes and assesses the antagonistic effects by retinoids and bryostatins on PMA action in relation to the multistep program of squamous differentiation. Treatment of normal human epidermal keratinocytes (NHEK) with PMA induces terminal cell division (irreversible growth-arrest) and causes a time- and dose-dependent increase in the incorporation of Na235SO4 into cholesterol sulfate, a marker for squamous cell differentiation. This stimulation in sulfate incorporation appears specific for cholesterol sulfate and is due to increased levels of cholesterol sulfotransferase activity. The increase in cholesterol sulfate accumulation parallels the increase in transglutaminase type I, another marker for squamous differentiation. Several transformed NHEK cell lines do not exhibit increased levels of cholesterol sulfate and transglutaminase type I activity after PMA treatment, indicating that they acquired defects in the regulation of squamous differentiation. Bryostatins 1 and 2, and several diacylglycerol analogues neither inhibit cell proliferation nor increase cholesterol sulfate synthesis or transglutaminase activity, indicating that these agents do not induce terminal differentiation. In contrast, the bryostatins block the increase in cholesterol sulfate and transglutaminase activity as well as the commitment to terminal cell division by PMA. Bryostatin 1 inhibits the commitment to terminal cell division and the accumulation of cholesterol sulfate significantly even when added 8 h after PMA administration. Retinoids inhibit cholesterol sulfate accumulation and the increase in transglutaminase activity by PMA but do not affect the commitment to terminal cell division. In summary, phorbol esters induce in NHEK cells a program of squamous differentiation. This process of differentiation consists of the commitment to terminal cell division and expression of the squamous phenotype. Expression of this phenotype is accompanied by an accumulation of cholesterol sulfate and increased cholesterol sulfotransferase activity. Bryostatins 1 and 2 and retinoic acid affect this differentiation process at different stages. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHORBOL esters
KW - TRETINOIN
KW - CHOLESTEROL
KW - KERATINOCYTES
KW - EPIDERMIS
KW - CELL differentiation
N1 - Accession Number: 12277374; Jetten, Anton M. 1 George, Margaret A. 1 Pettit, George R. 2 Herald, Cherry L. 2 Rearick, James I. 3; Affiliation: 1: Cell Biology Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2: Cancer Research Institute and Department of Chemistry, Arizona State University, Temple, Arizona 3: Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri, U.S.A.; Source Info: Jul89, Vol. 93 Issue 1, p108; Subject Term: PHORBOL esters; Subject Term: TRETINOIN; Subject Term: CHOLESTEROL; Subject Term: KERATINOCYTES; Subject Term: EPIDERMIS; Subject Term: CELL differentiation; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277374
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104754238
T1 - HIV and HTLV-I infections in the Americas: a regional perspective.
AU - Quinn, T C
AU - Zacarias, F R
AU - St John, R K
Y1 - 1989/07//1989 Jul
N1 - Accession Number: 104754238. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R.
KW - Acquired Immunodeficiency Syndrome -- Epidemiology
KW - RNA Virus Infections -- Epidemiology
KW - Acquired Immunodeficiency Syndrome -- Complications
KW - Acquired Immunodeficiency Syndrome -- Transmission
KW - Central America
KW - RNA Virus Infections -- Complications
KW - RNA Virus Infections -- Transmission
KW - Health
KW - North America
KW - Population Surveillance
KW - Preventive Health Care
KW - Retrovirus Infections -- Epidemiology
KW - South America
SP - 189
EP - 209
JO - Medicine
JF - Medicine
JA - MEDICINE
VL - 68
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - With over 143,000 cases of AIDS reported to the World Health Organization from 145 countries and with an estimated 5 to 10 million people worldwide infected with HIV, AIDS has become firmly established as a global pandemic. In the region of the Americas over 100,862 cases of AIDS have been reported with indigenous transmission documented in 45 to 46 countries. While North America has the highest annual number of AIDS cases per population, with 72 cases/million, the Caribbean subregion has a disproportionately high number of cases, with annual rates as high as 200 to 300 cases/million population for some countries. Despite differences in absolute number of cases, there has been a remarkable similarity in the temporal rate of increase of AIDS in the countries of the Americas, reflecting delayed introduction of the virus to some areas with an early exponential increase similar to that observed initially in the United States. Although the modes of transmission of HIV are the same throughout the region, evidence of increasing bisexual and heterosexual transmission, particularly in the Caribbean subregion, has resulted in a lower male-to-female ratio of AIDS cases and increased perinatal transmission. Clinically, a resurgence of diarrheal diseases, respiratory infections, and tuberculosis has been documented in association with HIV infection in many tropical countries of the Americas. With relatively high rates of HTLV-I infection already established in the Caribbean subregion, the overall public health problems of the Americas will be markedly potentiated by further spread of these 2 human retroviruses. If HIV infection continues to penetrate the poor and less advantaged populations in Latin America and the Caribbean, the potential exists for a massive epidemic in the Americas that may rapidly parallel the situation in Africa.
SN - 0025-7974
AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
U2 - PMID: 2544782.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Interferon Alfa May Suppress Chronic Infection by AIDS Virus.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 17
EP - 17
SN - 00987484
AB - Reports on the study finding that interferon alfa may suppress expression of human immunodeficiency virus type 1 (HIV-1) in chronically infected promonocytes and T-lymphocytes. Study by Anthony Fauci and Guido Poli of the National Institute of Allergy and Infectious Diseases and colleagues.
KW - INTERFERONS
KW - HIV (Viruses)
KW - T cells
KW - FAUCI, Anthony S., 1940-
KW - POLI, Guido
N1 - Accession Number: 10981808; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: INTERFERONS; Subject Term: HIV (Viruses); Subject Term: T cells; People: FAUCI, Anthony S., 1940-; People: POLI, Guido; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Some Genetic Factors in Colorectal Carcinomas Identified.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 17
EP - 17
SN - 00987484
AB - Reports on researchers' identification of genetic events underlying tumorigenesis in colorectal carcinomas. Study by Bert Vogelstein and colleagues; Finding that allelic deletions were common; Potential for improving assessment of prognosis; Related study with finding that chromosome 17 deletions and p53 genetic mutations may be involved in colorectal neoplasia.
KW - COLON cancer
KW - CARCINOGENESIS
KW - MEDICAL genetics
KW - VOGELSTEIN, Bert, 1949-
N1 - Accession Number: 10981809; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: COLON cancer; Subject Term: CARCINOGENESIS; Subject Term: MEDICAL genetics; People: VOGELSTEIN, Bert, 1949-; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Information on AIDS Trials Available.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 17
EP - 17
SN - 00987484
AB - Reports on the establishment of an AIDS Clinical Trials Information Service by the National Institutes of Allergy and Infectious Diseases, in cooperation with the Centers for Disease Control. Provision and updating of information about National Institutes of Health (NIH)-sponsored trials of experimental therapies for patients with AIDS and AIDS-related diseases.
KW - AIDS (Disease)
KW - CLINICAL trials
KW - INFORMATION services
KW - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 10981810; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: AIDS (Disease); Subject Term: CLINICAL trials; Subject Term: INFORMATION services; Company/Entity: NATIONAL Institute of Allergy & Infectious Diseases (U.S.) Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 1/9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Dipyridamole May Enhance Effectiveness of AIDS Therapy.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 17
EP - 17
SN - 00987484
AB - Reports on an in vitro study demonstrating that the platelet antiaggregant and coronary vasodilator dipyridamole (Persantine) potentiates the anti-HIV effects of zidovudine (AZT) and of dideoxycytidine in human monocyte/macrophages. Findings of scientists at the National Cancer Institute, the National Institutes of Dental Research and their associates.
KW - VASODILATORS
KW - AZT (Drug)
KW - AIDS (Disease) -- Treatment
KW - DRUG synergism
KW - MACROPHAGES
N1 - Accession Number: 10981811; Wyngaarden, James B. 1; Affiliation: 1: National Institutes of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p17; Subject Term: VASODILATORS; Subject Term: AZT (Drug); Subject Term: AIDS (Disease) -- Treatment; Subject Term: DRUG synergism; Subject Term: MACROPHAGES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sempos, Christopher
AU - Fulwood, Robinson
AU - Haines, Carol
AU - Carroll, Margaret
AU - Anda, Robert
AU - Williamson, David F.
AU - Remington, Patrick
AU - Cleeman, James
T1 - The Prevalence of High Blood Cholesterol Levels Among Adults in the United States.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 45
EP - 52
SN - 00987484
AB - Estimates the prevalence of high blood cholesterol levels among adults in the U.S. Use of the National Cholesterol Education Program's Guidelines for the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults and the serum total cholesterol and lipopoprotein date from the second National Health and Nutrition Examination Survey.
KW - BLOOD cholesterol
KW - PUBLIC health
KW - BLOOD lipoproteins
KW - HEALTH surveys
KW - UNITED States
N1 - Accession Number: 10981814; Sempos, Christopher 1 Fulwood, Robinson 2 Haines, Carol 2 Carroll, Margaret 1 Anda, Robert 3 Williamson, David F. 3 Remington, Patrick 3,4 Cleeman, James 2; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control 2: National Heart, Lung, and Blood Institute, National Institutes of Health 3: Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control 4: Bureau of Community Health and Prevention, Wisconsin Division of Health; Source Info: 7/7/89, Vol. 262 Issue 1, p45; Subject Term: BLOOD cholesterol; Subject Term: PUBLIC health; Subject Term: BLOOD lipoproteins; Subject Term: HEALTH surveys; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyngaarden, James B.
T1 - Information on AIDS Trials Available.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/07/
VL - 262
IS - 1
M3 - Article
SP - 17
EP - 17
SN - 00987484
AB - Reports on the establishment of an AIDS Clinical Trials Information Service by the National Institutes of Allergy and Infectious Diseases, in cooperation with the Centers for Disease Control. Provision and updating of information about National Institutes of Health (NIH)-sponsored trials of experimental therapies for patients with AIDS and AIDS-related diseases.
KW - AIDS (Disease)
KW - CLINICAL trials
KW - INFORMATION services
KW - NATIONAL Institute of Allergy & Infectious Diseases (U.S.)
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 10981810; Wyngaarden, James B. 1; Source Information: 7/7/89, Vol. 262 Issue 1, p17; Subject: AIDS (Disease); Subject: CLINICAL trials; Subject: INFORMATION services; Subject: NATIONAL Institute of Allergy & Infectious Diseases (U.S.); Subject: CENTERS for Disease Control & Prevention (U.S.); Number of Pages: 1/9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Haverkos, Harry W.
AU - Bukoski Jr., William J.
AU - Amsel, Zili
AU - Haverkos, H W
AU - Bukoski, W J Jr
AU - Amsel, Z
T1 - The initiation of male homosexual behavior.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/28/
VL - 262
IS - 4
M3 - letter
SP - 501
EP - 501
SN - 00987484
AB - Presents a letter to the editor reporting on the initiation of homosexuality intercourse, based on the data collected by the U.S. Centers for Disease Control, published in the 'Journal of American Medical Association'.
KW - LETTERS to the editor
KW - HOMOSEXUALITY
KW - AIDS (Disease) -- Prevention
KW - AGE distribution (Demography)
KW - HUMAN sexuality
KW - SEX education
N1 - Accession Number: 10975802; Haverkos, Harry W. 1 Bukoski Jr., William J. Amsel, Zili Haverkos, H W Bukoski, W J Jr Amsel, Z; Affiliation: 1: National Institute on Drug Abuse, Rockville, Md.; Source Info: 7/28/89, Vol. 262 Issue 4, p501; Subject Term: LETTERS to the editor; Subject Term: HOMOSEXUALITY; Subject Term: AIDS (Disease) -- Prevention; Subject Term: AGE distribution (Demography); Subject Term: HUMAN sexuality; Subject Term: SEX education; Number of Pages: 1p; Illustrations: 1 Graph; Document Type: letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kiebanoff, Mark A.
AU - Shiono, Patricia H.
AU - Berendes, Heinz W.
AU - Rhoads, George G.
T1 - Facts and Artifacts About Anemia and Preterm Delivery.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/28/
VL - 262
IS - 4
M3 - Article
SP - 511
EP - 515
SN - 00987484
AB - Examines the effects of maternal anemia on the pathogenesis of preterm birth. Incidence of preterm birth among women with and without anemia; Dose-response effect for anemia; Comparison of hematocrits from women who are in preterm and term labor.
KW - ANEMIA
KW - PREMATURE labor
KW - HEMATOCRIT
KW - UNITED States
N1 - Accession Number: 10975839; Kiebanoff, Mark A. 1 Shiono, Patricia H. 1 Berendes, Heinz W. 1 Rhoads, George G. 1; Affiliation: 1: Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.; Source Info: 7/28/89, Vol. 262 Issue 4, p511; Subject Term: ANEMIA; Subject Term: PREMATURE labor; Subject Term: HEMATOCRIT; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maton, Paul N.
AU - Norton, Jeffrey A.
AU - Nieman, Lynnette K.
AU - Doppman, John L.
AU - Jensen, Robert T.
T1 - Multiple Endocrine Neoplasia Type II With Zollinger-Ellison Syndrome Caused by a Solitary Pancreatic Gastrinoma.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/28/
VL - 262
IS - 4
M3 - Article
SP - 535
EP - 537
SN - 00987484
AB - Reports on the cases of patients with multiple endocrine neoplasia (MEN) type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. Forms of MEN; Clinical manifestations and symptoms; Comparison with other related diseases; Treatment options.
KW - ENDOCRINE glands -- Tumors
KW - ZOLLINGER-Ellison syndrome
KW - SYMPTOMS
N1 - Accession Number: 10975844; Maton, Paul N. 1 Norton, Jeffrey A. 2 Nieman, Lynnette K. 3 Doppman, John L. 4 Jensen, Robert T. 1; Affiliation: 1: Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 2: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda 3: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda 4: Diagnostic Radiology, the Clinical Center, National Institutes of Health, Bethesda; Source Info: 7/28/89, Vol. 262 Issue 4, p535; Subject Term: ENDOCRINE glands -- Tumors; Subject Term: ZOLLINGER-Ellison syndrome; Subject Term: SYMPTOMS; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hallett, Mark
AU - Cohen, Leonardo G.
T1 - Magnetism.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/07/28/
VL - 262
IS - 4
M3 - Article
SP - 538
EP - 541
SN - 00987484
AB - Describes a method for the stimulation of nerve and brain for the treatment of a patient who experienced transient numbness of both hands diagnosed as multiple sclerosis. Signs and symptoms of multifocal disease in the central nervous system; Observation of the central motor pathways; Electric stimulation procedures; Magnetic stimulation; Treatment.
KW - NEURAL stimulation
KW - MULTIPLE sclerosis
KW - NERVOUS system -- Diseases
N1 - Accession Number: 10975845; Hallett, Mark 1 Cohen, Leonardo G. 1; Affiliation: 1: Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda; Source Info: 7/28/89, Vol. 262 Issue 4, p538; Subject Term: NEURAL stimulation; Subject Term: MULTIPLE sclerosis; Subject Term: NERVOUS system -- Diseases; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hilakivi, L. A.
AU - Lister, R. G.
T1 - Comparison Between BALB/cJ and BALB/cByJ Mice in Tests of Social Behavior and Resident-Intruder Aggression.
JO - Aggressive Behavior
JF - Aggressive Behavior
Y1 - 1989/08//
VL - 15
IS - 4
M3 - Article
SP - 273
EP - 280
PB - John Wiley & Sons, Inc.
SN - 0096140X
AB - The behavior of male mice from two BALB strains, the BALB/cJ strain and the BALB/ cByJ strain, was examined with a social behavior test and a resident-intruder paradigm. Prior to testing, the animals were isolated for 0, 2, 5, or 10 days. In the social behavior test the pairs of BALB/cJ mice spent more time in active social interaction than pairs of BALB/cByJ mice, although the latter strain showed more locomotor activity. BALB/cJ mice isolated for 5-10 days, when tested in a familiar environment were more aggressive than mice from the BALB/cByJ strain. In the resident-intruder paradigm, in which a resident BALB mouse was confronted with an intruder NIH Swiss mouse, the BALB/cByJ mice showed more social investigation in their home rage Inwards the intruders, but there were no significant differences between the two strains in the amounts of aggressive behavior exhibited. The resells of these experiments suggest that there are some differences in the social behavior of the genetically related BALB/cJ and BALB/cByJ mice. However, the differences appear subtle and paradigm-specific. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aggressive Behavior is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERPERSONAL relations
KW - SOCIAL interaction
KW - AGGRESSION (Psychology)
KW - GENETICS
KW - PERSONALITY
KW - MICE as laboratory animals
KW - aggression
KW - genetics
KW - isolation
KW - mouse
N1 - Accession Number: 47683917; Hilakivi, L. A. 1 Lister, R. G. 1; Affiliation: 1: National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies, DICBR, Bethesda, Maryland; Source Info: 1989, Vol. 15 Issue 4, p273; Subject Term: INTERPERSONAL relations; Subject Term: SOCIAL interaction; Subject Term: AGGRESSION (Psychology); Subject Term: GENETICS; Subject Term: PERSONALITY; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: aggression; Author-Supplied Keyword: genetics; Author-Supplied Keyword: isolation; Author-Supplied Keyword: mouse; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morales, Pilar Garcia
AU - Barriocanal, Javier G.
AU - Sandoval, Ignacio V.
T1 - Reduced temperaturedoes not prevent transport of lysosomal integral membrane proteins from endoplasmic reticulum and through the Golgi system to lysosomes.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1989/08//8/1/89
VL - 183
IS - 2
M3 - Article
SP - 407
EP - 412
PB - Wiley-Blackwell
SN - 00142956
AB - The effect of low temperature on the transport of three lysosomal integral membrane proteins (I, II and III) from endoplasmic reticulum to lysosomes has been studied in normal rat kidney cells. At 15°C and 18°C, though slowly, the proteins could leave the endoplasmic reticulum, move through the Golgi system from the cis to the trans side, and accumulate in lysosomes. Transport of these proteins at low temperature occurred slower than at 37 °C. Both at low temperature and 37 °C, the proteins were transported between the endoplasmic reticulum and Golgi (III > I and II) and from Golgi to lysosomes (II > III > > I) with different rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW temperatures
KW - MEMBRANE proteins
KW - ENDOPLASMIC reticulum
KW - GOLGI apparatus
KW - CELL organelles
KW - LYSOSOMES
KW - CYTOLOGY
N1 - Accession Number: 13728012; Morales, Pilar Garcia 1 Barriocanal, Javier G. 1 Sandoval, Ignacio V. 1; Affiliation: 1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda; Source Info: 8/1/89, Vol. 183 Issue 2, p407; Subject Term: LOW temperatures; Subject Term: MEMBRANE proteins; Subject Term: ENDOPLASMIC reticulum; Subject Term: GOLGI apparatus; Subject Term: CELL organelles; Subject Term: LYSOSOMES; Subject Term: CYTOLOGY; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gammon, W. R.
AU - Yancey, K. B.
AU - Mangum, Karen L.
AU - Hendrix, John D.
AU - Hammer, C. H.
T1 - Generation of C5-Dependent Bioactivity by Tissue-Bound Anti-BMZ Autoantibodies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/08//
VL - 93
IS - 2
M3 - Article
SP - 195
EP - 200
SN - 0022202X
AB - We previously reported that complement-binding anti-basement membrane zone (BMZ) auto antibodies can mediate complement-dependent directed migration and adherence of leukocytes to the BMZ in cryostat skin sections and that there is heterogeneity in the ability of anti-BMZ auto antibodies to mediate that response. Those observations suggested that directed migration and adherence of leukocytes to the BMZ might be dependent on the amount of complement-activating autoantibody deposited at the BMZ and the extent to which those antibodies could activate complement and generate C5-derived peptides (C5a, C5a des arg). In this study, we have examined the role of autoantibody concentration and C5 in mediating the adherence response. When cryostat skin sections were pretreated with anti-BMZ auto antibodies and subsequently incubated with neutrophils suspended in fresh serum, neutrophils adhered to the BMZ. Adherence was anti-BMZ autoantibody specific and proportional to anti-BMZ autoantibody concentration. To determine the role of C5 in mediating adherence, neutrophils were suspended in increasing concentrations of: 1) fresh serum, 2) heat-inactivated serum, 3) serum pretreated with antihuman C5, 4) serum pretreated with antihuman IgG, 5) C5-depleted serum, 6) purified C5, and 7) C5-depleted serum reconstituted with increasing concentrations of purified C5. The suspensions were then incubated with autoantibody-treated skin sections. The results showed a dose-dependent requirement for fresh serum and for C5-depleted serum reconstituted with increasing doses of C5. Adherence could be detected with C5 concentrations less than 200 ng/ml, which correspond to a C5a/C5a des arg concentration of 10-8 -10-9 molar. These results suggest that complement-dependent neutrophil adherence is a highly sensitive method for detecting and quantitating the abilty of tissue-deposited anti-BMZ autoantibodies to activate complement and generate C5-derived bioactive peptides, for estimating the amount of C-activating anti-BMZ autoantibody deposited at the BMZ in vivo, and for evaluating the potential role of C-activating anti-BMZ autoantibodies in the pathogenesis of lesions [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Cancer
KW - BASAL lamina
KW - AUTOANTIBODIES
KW - LEUCOCYTES
KW - CRYOSTATS
KW - SERUM
N1 - Accession Number: 12277570; Gammon, W. R. 1 Yancey, K. B. 2 Mangum, Karen L. 1,2 Hendrix, John D. 1 Hammer, C. H. 3; Affiliation: 1: Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, U.S.A. 2: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A. 3: Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug89, Vol. 93 Issue 2, p195; Subject Term: SKIN -- Cancer; Subject Term: BASAL lamina; Subject Term: AUTOANTIBODIES; Subject Term: LEUCOCYTES; Subject Term: CRYOSTATS; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12277570
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06500-013
AN - 2006-06500-013
AU - Kochanska, Grazyna
T1 - The Study of Empathy Comes of Age.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1989/08//
VL - 34
IS - 8
SP - 742
EP - 744
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06500-013. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Kochanska, Grazyna; Laboratory of Developmental Psychology, National Institute of Mental Health, Bethesda, MD, US. Release Date: 20061211. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Emotional Development; Empathy; Prosocial Behavior; Psychosocial Development. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Reviewed Item: Eisenberg, Nancy (Ed); Strayer, Janet (Ed). Empathy and its Development=New York: Cambridge University Press, 1987. 406 pp. $49.50; 1987. References Available: Y. Page Count: 3. Issue Publication Date: Aug, 1989.
AB - Reviews the book, Empathy and its Development edited by Nancy Eisenberg and Janet Strayer (1987). This book is yet another integrative book in the relatively recent, but quickly growing, field of prosocial behavior. Addressed to professionals and graduate students, this text is a comprehensive selection of chapters by competent researchers in the field. It is divided into four sections focused respectively on history and theory, development, current research issues, and methodology. In summary, we have gained a valuable publication. It contains both systematic reviews, and papers that pose new questions and outline new research directions. It is of great interest to scholars and practitioners in the field of social and emotional development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - empathy
KW - emotional development
KW - prosocial behavior
KW - 1989
KW - Emotional Development
KW - Empathy
KW - Prosocial Behavior
KW - Psychosocial Development
KW - 1989
U2 - Eisenberg, Nancy (Ed); Strayer, Janet (Ed). (1987); Empathy and its Development; New York: Cambridge University Press, 1987. 406 pp. $49.50; 0-521-32609-5.
DO - 10.1037/030983
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lawley, Thomas J.
AU - Kubota, Yasuo
T1 - Induction of Morphologic Differentiation of Endothelial Cells in Culture.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/08/15/Aug89 Supplement
VL - 93
M3 - Article
SP - 59S
EP - 61S
SN - 0022202X
AB - Human endothelial cells when grown in cell culture assume a "cobblestone" morphology and do not form tubes or capillarylike structures. We have recently identified a culture substrate containing basement membrane-derived proteins that promotes morphologic differentiation of human umbilical vein and human dermal microvascular endothelial cells into capillarylike tubes. This differentiation is rapid, beginning within 1 h and is complete by 8-12 h. On electron microscopy these cells form a lumen, derived from remodeling of multiple cells and also by forming holes in the cytoplasm of individual cells. The endothelial cells no longer proliferate when cultured on this substrate known as matrigel, but can be induced to do so when cultured on fibronectin. We have also identified a critical molecular signal for endothelial cell differentiation induced by matrigel. Laminin, a prime constituent of matrigel, and to a lesser extent collagen IV appear to be key elements in the differentiation of endothelial cells induced by matrigel. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - ENDOTHELIUM
KW - EPITHELIUM
KW - CELL culture
KW - CULTURES (Biology)
KW - ELECTRON microscopy
N1 - Accession Number: 12581070; Lawley, Thomas J. 1 Kubota, Yasuo 2; Affiliation: 1: Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia. 2: Dermatology Branch, National Institutes of Health, Bethesda, Maryland, U.S.A.; Source Info: Aug89 Supplement, Vol. 93, p59S; Subject Term: CELLS; Subject Term: ENDOTHELIUM; Subject Term: EPITHELIUM; Subject Term: CELL culture; Subject Term: CULTURES (Biology); Subject Term: ELECTRON microscopy; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12581070
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sporn, Michael B.
AU - Roberts, Anita B.
T1 - Transforming Growth Factor-β: Multiple Actions and Potential Clinical Applications.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/08/18/
VL - 262
IS - 7
M3 - Article
SP - 938
EP - 941
SN - 00987484
AB - Cites the potential clinical applications of the transformation of growth factor-beta (TGF-beta). Use of TGF-beta in common clinical conditions for which there are no adequate pharmacologic agents; Identification of TGF-beta in an assay; Enhancement of the growth of fibroblasts in soft agar.
KW - TRANSFORMING growth factors-beta
KW - BIOLOGICAL assay
KW - FIBROBLASTS
KW - AGAR
N1 - Accession Number: 10981965; Sporn, Michael B. 1 Roberts, Anita B. 1; Affiliation: 1: Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Md.; Source Info: 8/18/89, Vol. 262 Issue 7, p938; Subject Term: TRANSFORMING growth factors-beta; Subject Term: BIOLOGICAL assay; Subject Term: FIBROBLASTS; Subject Term: AGAR; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 2 Black and White Photographs, 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malloy, Michael H.
AU - Kleinman, Joel C.
AU - Bakewell, Janice M.
AU - Schramm, Wayne F.
AU - Land, Garland H.
T1 - Maternal Smoking during Pregnancy: No Association with Congenital Malformations in Missouri 1980-83.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/09//
VL - 79
IS - 9
M3 - Article
SP - 1243
EP - 1246
PB - American Public Health Association
SN - 00900036
AB - Abstract: Using a multisource birth defects registry developed by the Missouri Center for Health Statistics for the years 1980-83, we examined the relation between maternal smoking during pregnancy and the occurrence of congenital malformations. There were 288,067 live singleton births in this data set of which 10,223 had one or more congenital malformations. When adjusted for potential confounders the odds ratio for congenital malformations in the infants of women who smoked during pregnancy was not increased (odds ratio = 0.98, 95% confidence interval = 0.94 - 1.03). We examined the relation between smoking and groups of malformations using the International Classification of Diseases, 9th Revision, as well as analyzing for certain specific malformations within each group and found no increased risk for infants of smokers. (Am J Public Health 1989; 79:1243-1246). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN abnormalities
KW - MEDICAL statistics
KW - SMOKING
KW - PREGNANCY
KW - GENETIC disorders
KW - PREGNANT women
KW - NOSOLOGY
KW - INFANTS
KW - MISSOURI
N1 - Accession Number: 4685442; Malloy, Michael H. 1 Kleinman, Joel C. 2 Bakewell, Janice M. 3 Schramm, Wayne F. 3 Land, Garland H. 3; Affiliation: 1: Prevention Research Program, National Institute of Child Health and Human Development, Executive Plaza North, Rm 640, Bethesda, MD 20892 2: Division of Analysis, National Center for Health Statistics 3: Missouri Department of Health Jefferson City; Source Info: Sep89, Vol. 79 Issue 9, p1243; Subject Term: HUMAN abnormalities; Subject Term: MEDICAL statistics; Subject Term: SMOKING; Subject Term: PREGNANCY; Subject Term: GENETIC disorders; Subject Term: PREGNANT women; Subject Term: NOSOLOGY; Subject Term: INFANTS; Subject Term: MISSOURI; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kurinij, Nathlie
AU - Shiono, Patricia H.
AU - Ezrine, Sandi F.
AU - Rhoads, Geprge G.
T1 - Does Maternal Employment Affect Breast-Feeding?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/09//
VL - 79
IS - 9
M3 - Article
SP - 1247
EP - 1250
PB - American Public Health Association
SN - 00900036
AB - Abstract: A prospective survey of maternal employment and breast-feeding initiation and duration was conducted among 668 Black and 511 White women who delivered their first child in Washington, DC. Ninety-one percent of White women (n = 511) and 80 percent of Black women (n = 668) reported working during pregnancy. Black women who planned to return to work part time vs full time were more likely to breast-feed rather than formula-feed (adjusted odds ratio, 2.3; 95% confidence intervals (CI) = 1.4, 3.7). Using Cox regression, Black women who returned to work had a shorter duration of breast-feeding than those not returning to work (hazard ratio = 0.5 (CI = 0.3, 0.9)). Black and White women returning to professional occupations had a longer duration of breast-feeding compared to women returning to sales or technical positions (hazard ratio for Black women = 2.4 (CI = 1.4, 4.4); hazard ratio for White women = 1.6 (CI = 1.0, 2.5)). In addition, White women in professional occupations had a longer duration of breastfeeding than women in clerical positions (hazard ratio = 1.7 (CI = 1.1, 2.6)). Until employers in the United States develop a maternity policy which does not discourage breast-feeding, the recommended six months of breast-feeding will be difficult to achieve for most employed women. (Am J Public Health 1989; 79:1247-1250). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURVEYS
KW - WOMEN -- Employment
KW - BREASTFEEDING (Humans)
KW - AFRICAN American women
KW - PREGNANCY
KW - PROFESSIONAL employees
KW - MOTHERHOOD
KW - WASHINGTON (D.C.)
KW - UNITED States
N1 - Accession Number: 4685492; Kurinij, Nathlie 1 Shiono, Patricia H. 2 Ezrine, Sandi F. 3 Rhoads, Geprge G. 2; Affiliation: 1: Clinical Vision Research Branch, National Eye Institute, NIH, Building 31, Room 6A49, Bethesda, MD 20892 2: Epidemiology Branch, Prevention Research Program, NICHD/NIH 3: Research Associate, Inc., Baltimore, MD; Source Info: Sep89, Vol. 79 Issue 9, p1247; Subject Term: SURVEYS; Subject Term: WOMEN -- Employment; Subject Term: BREASTFEEDING (Humans); Subject Term: AFRICAN American women; Subject Term: PREGNANCY; Subject Term: PROFESSIONAL employees; Subject Term: MOTHERHOOD; Subject Term: WASHINGTON (D.C.); Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chan, C. C.
AU - Ottesen, E. A.
AU - Awadzi, K.
AU - Badu, R.
AU - Nussenblatte, R. B.
T1 - Immunopathology of ocular onchocerciasis. I. Inflammatory cells infilitrating the anterior segment.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1989/09//
VL - 77
IS - 3
M3 - Article
SP - 367
EP - 372
PB - Wiley-Blackwell
SN - 00099104
AB - Ocular tissue (conjunctiva and iris) was obtained from 12 adult African men with active ocular onchocerciasis and from nine age-matched persons from the same endemic region but without onchocercal infection. These tissues were examined immunohistologically and two major findings were noted. First, mild-to-moderate chronic inflammatory cellular infiltration was present in the conjunctiva of the onchocerciasis patients. T lymphocytes (CD3+) were the major inflammatory cells, and the T suppressor/cytotoxic (CD8+) subset was significantly increased in the ocular onchocerciasis patients (P < 0.03). Second, in the onchocerciasis patients, non-lymphoid cells of the conjunctiva and iris, such as vascular endothelium, pericytes and fibroblasts were in an activated slate, as shown by increased expression of Class M MHC antigens (P < 0.02, conjunctiva; P < 0.05, iris). These concomitant findings of lymphocyte infiltration and resident ceil activation indicate a dynamic state of localized host responsiveness presumably to the microfilarial parasites and their products in the anterior segments of the eyes of patients with ocular onchocerciasis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FILARIASIS
KW - ONCHOCERCIASIS
KW - CONJUNCTIVA
KW - PRESERVATION of organs, tissues, etc.
KW - ENDOTHELIUM
KW - LEUCOCYTES
KW - onchocerciasis conjunctiva iris immunopathology ocular inflammation
N1 - Accession Number: 15987682; Chan, C. C. 1 Ottesen, E. A. 2 Awadzi, K. 3 Badu, R. 3 Nussenblatte, R. B. 1; Affiliation: 1: National Eye Institute, Bethesda, MD, USA. 2: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA. 3: Onchocerciasis Chemotherapeutic Research Centre, Tamale, Ghana.; Source Info: Sep1989, Vol. 77 Issue 3, p367; Subject Term: FILARIASIS; Subject Term: ONCHOCERCIASIS; Subject Term: CONJUNCTIVA; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: ENDOTHELIUM; Subject Term: LEUCOCYTES; Author-Supplied Keyword: onchocerciasis conjunctiva iris immunopathology ocular inflammation; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Larsen, C. G.
AU - Anderson, A. O.
AU - Oppenheim, J. J.
AU - Matsushima, K.
T1 - Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor.
JO - Immunology
JF - Immunology
Y1 - 1989/09//
VL - 68
IS - 1
M3 - Article
SP - 31
EP - 36
PB - Wiley-Blackwell
SN - 00192805
AB - Cultured normal human fibroblasts were stimulated to produce neutrophil-activating protein/interleukin-8 (IL-8) in response to IL-1α (0.1-1000 U/ml) or turnout necrosis factor (TNF) α (0.1-1000 U/ml). Induction of mRNA for IL-8 in fibroblasts was rapid (within 30 min) and maximal responses were obtained with either 100 U/ml IL-1α or 100 U/ml TNFα. Expression of mRNA for IL- 8 was accompanied by the production of high levels of neutrophil chemotactic activity. IL-1α (1000 U/ml), but not TNFα, induced mRNA for IL-8 in cultured normal human keratinocytes. The relevance of production of IL-8 by these cell types was evaluated further by comparing the local inflammatory effects of IL-1α, TNFα and IL-8. Intradermal injection of either recombinant IL-8, IL-1α or TNFα lead to a similar in vivo effect, i.e. dose-dependent accumulation of lymphocytes and polymorphonuclear leucocytes at sites of injection. The in vivo attraction of neutrophils and lymphocytes to the site of injection by TNF or IL-1 (which is not chemotactic for neutrophils or lymphocytes in vitro), may be partly mediated by locally produced IL-8. Thus, IL-8 may be a vital participant in the cascade of interacting cytokines that is induced by tissue injury and immunologically induced inflammation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - INTERLEUKIN-8
KW - KERATINOCYTES
KW - DERMIS
KW - INTERLEUKIN-1
KW - TUMOR necrosis factor
N1 - Accession Number: 13357276; Larsen, C. G. 1 Anderson, A. O. 1 Oppenheim, J. J. 2 Matsushima, K. 1; Affiliation: 1: Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute 2: Laboratory of Respiratory and Mucosal Immunity, Disease Assessment Division, USAM RIID, Fort Detrick, Frederick, Maryland, U.S.A.; Source Info: Sep89, Vol. 68 Issue 1, p31; Subject Term: FIBROBLASTS; Subject Term: INTERLEUKIN-8; Subject Term: KERATINOCYTES; Subject Term: DERMIS; Subject Term: INTERLEUKIN-1; Subject Term: TUMOR necrosis factor; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirshenbaum, A. S.
AU - Goff, J. P.
AU - Metcalfe, D. D.
T1 - Human macrophages cultured on agar but not agarose resemble mast cells.
JO - Immunology
JF - Immunology
Y1 - 1989/09//
VL - 68
IS - 1
M3 - Article
SP - 120
EP - 125
PB - Wiley-Blackwell
SN - 00192805
AB - It has been reported that rare colonies of mast cells may be identified when human bone marrow cells are cultured in agar. Based on this observation, we attempted to culture mast cells from human bone marrow using a modified agar interphase culture. Metachromatically staining cells appearing in culture peaked in number by 2-3 weeks and consisted of basophil-like cells, mast-like cells and larger, granulated cells superficially resembling mast cells. The large cells, which constituted the majority of metachromatic cells, were berberine sulphate-positive but negative for histamine, chloroacetate esterase, and mast cell tryptase. These larger granulated cells were subsequently identified as macrophages by FACS analysis with Leu M3 and by electron microscopy. Berberine sulphatestaining of macrophages was not due to the de novo synthesis of heparin, as shown by analysis of radiolabelled proteoglycans from cultured cells. The macrophage metachromasia was eliminated with the use of agarose. The metachromatic and berberine sulphate-staining of cultured human macrophages was therefore considered to be due to phagocytosed altar. Recognition of this phenomenon will aid in the proper identification of human mast cells and basophils in cultures where agar or similar substances are present, and demonstrates that berberbine sulphate-staining is not specific for heparin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - MAST cells
KW - BONE marrow cells
KW - HUMAN cell culture
KW - CELL culture
KW - BERBERINE
N1 - Accession Number: 13357385; Kirshenbaum, A. S. 1 Goff, J. P. 2 Metcalfe, D. D. 1; Affiliation: 1: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 2: Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland, U.S.A.; Source Info: Sep89, Vol. 68 Issue 1, p120; Subject Term: MACROPHAGES; Subject Term: MAST cells; Subject Term: BONE marrow cells; Subject Term: HUMAN cell culture; Subject Term: CELL culture; Subject Term: BERBERINE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raub, William
T1 - No Increased Risk for Children Conceived In Vitro.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09//9/1/89
VL - 262
IS - 9
M3 - Article
SP - 1158
EP - 1158
SN - 00987484
AB - Reports that children conceived by in vitro fertilization are at no greater risk of congenital malformation or developmental dysfunction than other children. Results of a study conducted by the Eastern Virginia Medical School; Score on the Mental and Psychomotor Development indexes of the Bayley Scales.
KW - FERTILIZATION in vitro
KW - GENETIC disorders
KW - CHILDREN with disabilities
N1 - Accession Number: 11019505; Raub, William 1; Affiliation: 1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: FERTILIZATION in vitro; Subject Term: GENETIC disorders; Subject Term: CHILDREN with disabilities; NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raub, William
T1 - T-Cell Receptor Gene May Influence Susceptibility to Multiple Sclerosis (MS):.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09//9/1/89
VL - 262
IS - 9
M3 - Article
SP - 1158
EP - 1158
SN - 00987484
AB - Reports that researchers have found that a gene within the T-cell receptor (TCR) beta-chain complex influences susceptibility to multiple sclerosis (MS). Analysis of the TCR-beta genotypes of 51 families in which one to three members were affected with the relapsing-remitting form of MS; Determination of the TCR-beta haploytpes by segregation analysis.
KW - MULTIPLE sclerosis -- Genetic aspects
KW - T cell receptors
N1 - Accession Number: 11019506; Raub, William 1; Affiliation: 1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: MULTIPLE sclerosis -- Genetic aspects; Subject Term: T cell receptors; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raub, William
T1 - Association Found Between Macular Degeneration and Lens Opacities:.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09//9/1/89
VL - 262
IS - 9
M3 - Article
SP - 1158
EP - 1158
SN - 00987484
AB - Reports that patients with lens opacities are at increased risk of having age-related macular degeneration (AMD). Comparison with the prevalence of AMD in subjects with no lens opacities; Support for the implantation of ultraviolet- and blue-light-absorbing intraocular lenses following removal.
KW - RETINAL degeneration
KW - OPACITY (Optics)
N1 - Accession Number: 11019507; Raub, William 1; Affiliation: 1: National Institutes of Health; Source Info: 9/1/89, Vol. 262 Issue 9, p1158; Subject Term: RETINAL degeneration; Subject Term: OPACITY (Optics); Number of Pages: 1/6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zonderman, Alan B.
AU - Costa Jr., Paul T.
AU - McCrae, Robert R.
AU - Zonderman, A B
AU - Costa, P T Jr
AU - McCrae, R R
T1 - Depression as a risk for cancer morbidity and mortality in a nationally representative sample.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09//9/1/89
VL - 262
IS - 9
M3 - journal article
SP - 1191
EP - 1195
SN - 00987484
AB - The relative risks for cancer morbidity and mortality associated with depressive symptoms were examined using data from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. The Center for Epidemiologic Studies Depression scale and the depression subscale from the General Well-being Schedule were used as predictors in this 10-year follow-up study of a nationally representative sample. No significant risk for cancer morbidity or mortality was associated with depressive symptoms with or without adjustment for age, sex, marital status, smoking, family history of cancer, hypertension, and serum cholesterol level. These data were also reanalyzed for subjects aged 55 years or older who were retraced by a second follow-up. Neither measure of depressive symptoms was a significant risk for cancer death during the 15-year follow-up interval. These results call into question the causal connection between depressive symptoms and cancer morbidity and mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER -- Mortality
KW - MENTAL depression
KW - HEALTH surveys
KW - UNITED States
N1 - Accession Number: 11019450; Zonderman, Alan B. 1 Costa Jr., Paul T. 1 McCrae, Robert R. 1 Zonderman, A B 2 Costa, P T Jr McCrae, R R; Affiliation: 1: Gerontology Research Center National Institute on Aging, National Institute of Heart, Baltimore 2: Gerontology Research Center, National Institute on Aging, Baltimore, Md 21224; Source Info: 9/1/89, Vol. 262 Issue 9, p1191; Subject Term: CANCER -- Mortality; Subject Term: MENTAL depression; Subject Term: HEALTH surveys; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Swerlick, Robert A.
AU - Yancey, Kim B.
AU - Lawley, Thomas J.
T1 - Inflammatory Properties of Human C5a and C5a des Arg/ in Mast Cell-Depleted Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/09//
VL - 93
IS - 3
M3 - Article
SP - 417
EP - 422
SN - 0022202X
AB - C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection. Histologically, these reactions are characterized by neutrophil-rich leukocytic infiltrates, leukocytoclasis, edema, and dermal mast cell degranulation. It has not been possible to assess in vivo the relative contributions of resident mast cells and circulating leukocytes to this reaction because the accumulation of leukocytes and degranulation of mast cells occur simultaneously after injection of these anaphylatoxins. To assess the role of mast cells in these inflammatory reactions, we have examined the reactivity of human skin selectively depleted of dermal mast cells by local corticosteroid treatment. Corticosteroid-treated skin became virtually devoid of dermal mast cells within 4-6 wk as assessed by light microscopy, immunofluorescence with fluorescein- conjugated avidin, or electron microscopy. Mast cell-depicted skin demonstrated normal vasopermeability and vasodilatory responsiveness to intradermal injection of histamine, but the reactivity of these sites to the mast cell secretagogue, morphine, was absent. Moreover, no clinical reactions were detectable in mast cell-depleted human skin after intradermal challenge with 50 ng of tither C5a or C5a des Arg, despite the fact that biopsies of these sites revealed substantial, neutrophil-rich infiltrates. These infiltrates were qualitatively and quantitatively identical to C5a or C5a des Mg-induced infiltrates in mast cell replete skin. This experimental approach in vivo has allowed the independent analysis of the anaphylactogenic and chemoattractant activities of human C5a and C5a des Arg in human skin, demonstrated the importance of dermal mast cells in these clinical responses. and shown that leukocytes can accumulate at these injection sites directly in response to these mediators. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLAMMATION -- Immunological aspects
KW - INTRADERMAL injections
KW - HISTOLOGY
KW - EDEMA
KW - MAST cells
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 12280306; Swerlick, Robert A. 1 Yancey, Kim B. 2 Lawley, Thomas J. 1; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institutes of Health, Betheseda, Maryland, U.S.A. 2: Department of Dermatology, Uniformed Services University of the Health Sciences, Betheseda, Maryland, U.S.A.; Source Info: Sep89, Vol. 93 Issue 3, p417; Subject Term: INFLAMMATION -- Immunological aspects; Subject Term: INTRADERMAL injections; Subject Term: HISTOLOGY; Subject Term: EDEMA; Subject Term: MAST cells; Subject Term: IMMUNOFLUORESCENCE; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12280306
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atkinson, Jane C.
AU - Chih-Ko Yeh
AU - Bermudez, Debra
AU - Fox, Philip C.
AU - Baum, Bruce J.
T1 - Longitudinal evaluation of major salivary gland function in HIV-1 infected patients.
JO - Journal of Oral Pathology & Medicine
JF - Journal of Oral Pathology & Medicine
Y1 - 1989/09//
VL - 18
IS - 8
M3 - Article
SP - 469
EP - 470
SN - 09042512
AB - Parotid and submandibular gland function were evaluated in 12 HIV antibody-positive men at two visits separated by a median interval of 14.5 months (range 6-22 months). Unstimulated and stimulated flow rates, and the concentrations of total protein, lysozyme, albumin and lactoferrin in these secretions, were determined. Parotid and submandibular gland secretions changed in a specific fashion with time. Lysozyme levels in both glandular stimulated secretions showed significant changes (≃40% and 70% elevated, between visits, in parotid and submandibular saliva, respectively). In addition, the frequency with which albumin was detected in unstimulated parotid secretions increased with time. These findings support earlier results suggesting the presence of alterations in major salivary gland function following HIV-1 infection. Submandibular gland function appears to manifest these alterations earlier, but with time the parotid secretions show similar changes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALIVARY glands
KW - EVALUATION
KW - HIV-positive persons
KW - HIV infections
KW - AIDS
KW - lysozyme
KW - parotid gland
KW - saliva
KW - submandibular gland.
N1 - Accession Number: 11658960; Atkinson, Jane C. 1 Chih-Ko Yeh 1 Bermudez, Debra 1 Fox, Philip C. 1 Baum, Bruce J. 1; Affiliation: 1: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland USA; Source Info: Sep1989, Vol. 18 Issue 8, p469; Subject Term: SALIVARY glands; Subject Term: EVALUATION; Subject Term: HIV-positive persons; Subject Term: HIV infections; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: lysozyme; Author-Supplied Keyword: parotid gland; Author-Supplied Keyword: saliva; Author-Supplied Keyword: submandibular gland.; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0714.ep11658960
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 1991-10757-001
AN - 1991-10757-001
AU - Probstfield, Jeffrey L.
T1 - Adherence and its management in clinical trials: Implications for arthritis treatment trials.
JF - Arthritis Care & Research
JO - Arthritis Care & Research
JA - Arthritis Care Res
Y1 - 1989/09//
VL - 2
IS - 3
SP - S48
EP - S57
CY - US
PB - John Wiley & Sons
SN - 0893-7524
N1 - Accession Number: 1991-10757-001. PMID: 2487704 Other Journal Title: Arthritis & Rheumatism: Arthritis Care & Research. Partial author list: First Author & Affiliation: Probstfield, Jeffrey L.; NIH National Heart, Lung, and Blood Institute Div of Epidemiology & Clinical Applications, Clinical Trials Branch, Bethesda, MD, US. Release Date: 19910401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: Symposium: Compliance in rheumatoid arthritis (1989, Phoenix, Arizona). Major Descriptor: Arthritis; Cardiovascular Disorders; Clinical Trials; Drug Therapy; Treatment Compliance. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Clinical Trial; Empirical Study. Page Count: 10. Issue Publication Date: Sep, 1989.
AB - Reviews principles of adherence in clinical trials, using data and examples from trials examining cardiovascular diseases. Issues reviewed include the importance of adherence in clinical trials and an overall program for adherence in clinical trials. Discussion focuses on a program for the management of poor adherence among 305 participants in a coronary primary prevention trial. A multifaceted preventive approach to eliminate reduced adherence in a clinical trial is also presented. Findings have implications for adherence in clinical trials of arthritis treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - program for management of poor adherence in clinical trials
KW - patients with cardiovascular diseases
KW - implications for arthritis treatment
KW - conference presentation
KW - 1989
KW - Arthritis
KW - Cardiovascular Disorders
KW - Clinical Trials
KW - Drug Therapy
KW - Treatment Compliance
KW - 1989
DO - 10.1002/anr.1790020314
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lisker-Melman, Mauricic
AU - Webb, David
AU - Di Bisceglie, Adrian M.
AU - Kassianides, Chris
AU - Martin, Paul
AU - Rustgi, Vinod
AU - Waggoner, Jeanne G.
AU - Park, Yoon
AU - Hoofnagle, Jay H.
AU - Lisker-Melman, M
AU - Webb, D
AU - Di Bisceglie, A M
AU - Kassianides, C
AU - Martin, P
AU - Rustgi, V
AU - Waggoner, J G
AU - Park, Y
AU - Hoofnagle, J H
T1 - Glomerulonephritis caused by chronic hepatitis B virus infection: treatment with recombinant human alpha-interferon.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1989/09/15/
VL - 111
IS - 6
M3 - journal article
SP - 479
EP - 483
SN - 00034819
AB -